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<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSD8</accession>
    <name>A0A231GSD8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000647">
        <property type="protein sequence ID" value="OXR39543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39543">
        <property type="protein sequence ID" value="OXR39543"/>
        <property type="gene ID" value="B7C42_08389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="6455" checksum="4F6654BFA1134FB8" modified="2017-10-25" version="1">MPTPAAAATSRIVIPANPSRDSTSTAALVSLSTVSACLPLSRRLVASTALDSPSDMCPDSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSH6</accession>
    <name>A0A231GSH6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sseA_2</name>
        <name evidence="4" type="ORF">B7C42_08390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000667">
        <property type="protein sequence ID" value="OXR39542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39542">
        <property type="protein sequence ID" value="OXR39542"/>
        <property type="gene ID" value="B7C42_08390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8465" checksum="D06AB8D35C04697C" modified="2017-10-25" version="1">MYRELAGSEELIVYSRVGERSSLTWFVLTFLLGLPAVRNYDGSWTEWGNSVRLPIAKGDEPGEAPVRPGRRARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSM0</accession>
    <name>A0A231GSM0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenol hydroxylase P5 protein</fullName>
            <ecNumber evidence="1">1.14.13.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dmpP_3</name>
        <name evidence="1" type="ORF">B7C42_08364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.7" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000370">
        <property type="protein sequence ID" value="OXR39568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39568">
        <property type="protein sequence ID" value="OXR39568"/>
        <property type="gene ID" value="B7C42_08364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018662">
        <property type="term" value="F:phenol 2-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="43" mass="4561" checksum="C8AA2E5A2604A548" modified="2017-10-25" version="1">MELDEPMEFSAGQYAELIVPGAGVGRQYSMANPPSEARTLCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSV3</accession>
    <name>A0A231GSV3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">galE_5</name>
        <name evidence="2" type="ORF">B7C42_08227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000083">
        <property type="protein sequence ID" value="OXR39703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39703">
        <property type="protein sequence ID" value="OXR39703"/>
        <property type="gene ID" value="B7C42_08227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="31600" checksum="C211C2F12B589ACA" modified="2017-10-25" version="1">MRVLVTGANGYVGRAVVAALSAAGHAPVAMVRVEGTEIAGATEMRRADLADIDSLRRAIRDVDVVCHLAALTRARDSFAEALQYVRVNTGGTIALLEAMDATGVSRIVFASTGAIYGAPERQPMNEEVPDAPPHPYAMSKRAAELAIEARAGGGEVAAVIARISNVAGGIDPDPTRLVPRALTAAARYSPLAINGDGSAVRDYLHLQDAAAAFVACVEHLPEAGTVVRYNIGSGHGTSVMDVVAAVERITGRPVPLEYGPAAPEPATLVCDPSKAIAEMHWRPCNSDIGTIVRDAWAAGAAASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT54</accession>
    <name>A0A231GT54_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hoxN_2</name>
        <name evidence="9" type="ORF">B7C42_08129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000063">
        <property type="protein sequence ID" value="OXR39800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39800">
        <property type="protein sequence ID" value="OXR39800"/>
        <property type="gene ID" value="B7C42_08129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00802">
        <property type="entry name" value="nico"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR39800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="40787" checksum="7FBDCDA074FC0C89" modified="2017-10-25" version="1">MTSTSRQRGLLRALAAHVRLSRAEVLRLAAIVGVIVGLHVLGWFTLVALVAPHNFSLGDKTLGIGVGLTAYTLGLRHAFDADHIAAIDNTTRKLMNDGQRPLSVGFFFSLGHSTVVFALALLLSVGVKTIVGPVEDDSSALHHYTGLIGTTVSGTFLYLIAIVNVVVLVGILRVFRRMRTGDYDEAELEHQLAHRGLMNRILAPVMRSITKPSQMYPVGVLFGLGFDTATEVALLVLAGTSAAAGLPWYAILCLPILFAAGMSLLDTIDGSFMNFAYGWAFAQPVRKVYYNITITALSVAVALIIGTIELLGLLADQTGWNGGPWDWITGLDLNLVGYLIVGLFVLTWAIALLTWRYGRIEERWTAALRRQTDITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTF7</accession>
    <name>A0A231GTF7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000059">
        <property type="protein sequence ID" value="OXR39835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39835">
        <property type="protein sequence ID" value="OXR39835"/>
        <property type="gene ID" value="B7C42_08097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="589" mass="63163" checksum="051769C005E46BD4" modified="2017-10-25" version="1">MALIFGIEQNRAVTRRVSALRAQARTRPTALRAALTKESRAAFSRRAGRIQLFPAVTAALLAGLAVAFAAYGFLRWITPVDATKQAAEIDITRVALTVVAGVGGVVALVIAYRRQRDLEQSRFVERFGAAAAQLGTTDVAVRIAGVYAMAGVADESDGPRRQQCIDVLCGYLRLPYSPELGANHQSKLVIKQHRATADNTHADDREHHHEYRHNDREVRATIVRVMTDHLRPEAAYSWSTADFDFRTAYLENVDFSRAQFSGAVRFGGATFSGDARFGSATFTGNAEFDGVTFAADAWFDGVTFSGNARFDGVTFSGRAYFDSANLSGHSRFDNATFTENASFAGANFSADARFGGATFAGDANFGETTFSRNARFDGVTFSRNAHFDGAAFSGNARFGNATFAADARFDGATLSGNARFGDATFSGNARFDGATFSGNTGFDSANFSGDAEFSEATFTGNAEFGDATFGGNTGFGGATFTGDAGFGGTIFSSNARFDHASFAGNTWFGSTTFAGKARFDQVTFTGNARFDEADFGSGTISFNEPRHWGPPTPVFDWSEDHSRKPANIEPQDWPPVVAASHQQAAKAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTK3</accession>
    <name>A0A231GTK3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB_2</name>
        <name evidence="10" type="synonym">asnB_1</name>
        <name evidence="10" type="ORF">B7C42_03623</name>
        <name evidence="9" type="ORF">B7C42_07980</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000050">
        <property type="protein sequence ID" value="OXR39946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39946">
        <property type="protein sequence ID" value="OXR39946"/>
        <property type="gene ID" value="B7C42_07980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44067">
        <property type="protein sequence ID" value="OXR44067"/>
        <property type="gene ID" value="B7C42_03623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR39946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="641" mass="72225" checksum="B7E31D7295FFB15B" modified="2017-10-25" version="1">MCGLLGFLTADVATDSVVQQVYDALQCGRHRGPDERGTWHDEHIILGFNRLSIIDIEHSHQPLRWGPPENTERYALAFNGEIYNYLELRTQLSEEFGARFATEGDGEAIVAAYHHWGTAAFSKLRGMFAFAIWDTETQELVLARDPFGIKPLFLATGPGGTAYASEKKSLLELLPALNLSDALDPRALEHYTVLQYVPEPESLHANIRRLESGCYATLRPGAAPEVTRYFEPNFRVRPFAAGSEEARYREIAAVLEDSVAKHMRADVTVGAFLSGGIDSTAIAALAIRHNPNLLTFTSAFEREGYSEADVAAETAEAIGAKHFIRTVSPEEFAGAIPEIVWYLDDPVADPALVPLYFVAQEARKHVKVVLSGEGSDELFGGYTIYREPLSLKPFEYLPKGVRRLAGKLSDRIPDGTRGKSLLHRGSLPLEQRYYGNARSFNDAQLRSVLREFRPEWTHQDVTAPIYARSRGWDPVARMQHLDLFTWLRGDILVKADKMTMANSLELRVPFLDPEVFAVAEQIPYQQKITKETTKYALRRALETIVPPHVLHRPKLGFPVPLRHWLRGPELYDWAATQIAESQTDHLLDKSAIKAMLEAHRAGNGDHSRRLWTLLVFMIWHGIFVEDRIKPDIQEPTYPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTT0</accession>
    <name>A0A231GTT0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fdxA_3</name>
        <name evidence="10" type="ORF">B7C42_07939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779235.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39988">
        <property type="protein sequence ID" value="OXR39988"/>
        <property type="gene ID" value="B7C42_07939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR39988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="11787" checksum="1BEA99DE40A9022B" modified="2017-10-25" version="1">MTYVISSPCIDVKDRACVDECPVDCIYEGARMLYIHPDECVDCGACEPVCPAEAIFFENDVPDKEASFTRINAEFFDDLGSPGGATGLGPVDADHPDVESIPVQETKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTY6</accession>
    <name>A0A231GTY6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000050">
        <property type="protein sequence ID" value="OXR39941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39941">
        <property type="protein sequence ID" value="OXR39941"/>
        <property type="gene ID" value="B7C42_07975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="105"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="46195" checksum="352DC55685D9D2D8" modified="2017-10-25" version="1">MALLGWSLNAVEAVDRFDRRYVVVAPEWAEEYCIEHEIPYLCWNFERLNDRSMEIAETLKEMGVDVAIPIFEETVEWAGAINSVLLGNPRLLGQAMLLRDKSLMKRRAQLGGIRVGIFEEAHERDDVIRFLKRVNQTLLKLDGDPNDPIHIKAFDKAGCLGHRVIRTPDEIDAIPDDEFPVLMESHLDGWEFAVEAWIHDGKIRFLNISEYVRLGYSVFVPATPELEKYRPEITRQVEKLIKTFDIEFGFVHPEYFVTSDGEMYFGEVAYRPPGFKVFELLERAYGFNAYHALVLAFDPKTTEEEIVEFFPREVVDAKGHAGSFGVYPRRRVVSRLSIPEETEDHEYFETHELTAPLSEKVTKRTAFGNHWGLLYFFGEDPYALRDLLKRQEELDFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUI2</accession>
    <name>A0A231GUI2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40266">
        <property type="protein sequence ID" value="OXR40266"/>
        <property type="gene ID" value="B7C42_07691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="118" mass="13239" checksum="EB209105FB2A85FC" modified="2017-10-25" version="1">MPHNPVSAVDLVLRDVDAVELLLQRVIERLEIEPQTDLDWVRQRALRTLADTVQQLTAAIARPLKPQPSTLDAVESQSPRAQSEPVAVETAAPPAESTPPGKDQRPKRRKNRHRPVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUZ0</accession>
    <name>A0A231GUZ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sseB_3</name>
        <name evidence="5" type="ORF">B7C42_07554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40388">
        <property type="protein sequence ID" value="OXR40388"/>
        <property type="gene ID" value="B7C42_07554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="176"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="30072" checksum="BD271667FCB5FAE5" modified="2017-10-25" version="1">MTSRTDSVITADELAERLDARVPVTVLDVRWQLDKPDGRKAYGAGHIPGAAYVDLESELSDRSITGRGRHPLPAGARLQAAARRWGARTGVPIVVYDNWNRAGSARAWWVLRAAGVTDVRILDGGLAAWTGIGRDLAQGNEQPMLGDLTVAYDNLYAGAANTVTADEAAGLTTAGVLIDARAPERFRGDSEPVDPVAGHIPGAVNVPYAGLLDEHGFFRPATELDAIFASAQVGDGRAVGAYCGSGVTAAVVIAALRITGIDAALFPGSWSQWSAEAGRPVAVAAPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVF0</accession>
    <name>A0A231GVF0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl-diphosphatase BcrC</fullName>
            <ecNumber evidence="2">3.6.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bcrC_2</name>
        <name evidence="2" type="ORF">B7C42_07288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40603">
        <property type="protein sequence ID" value="OXR40603"/>
        <property type="gene ID" value="B7C42_07288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="69"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="23046" checksum="6AA8C12F04F2A7BE" modified="2017-10-25" version="1">MSPTSLPATVSAFDGARIDGSLLVEVTEFAQHTRWLNTPILWFTDAGLIVFAVLMLAAWWRARRENTTAMAAALLAPVAVVAAFALAEIVKQIAAEPRPCHALPHAYILEACPPGTDYAFPSGHATVAAATVAALYLTNRRLAAIAAVFALFEAATRVYVGGHYPHDVAASAVLALPIAYLVRRALLQPAAAAVTRLRTGPLAPLVTSTVQSAARITLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVM3</accession>
    <name>A0A231GVM3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cutinase cut2</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cut2</name>
        <name evidence="3" type="ORF">B7C42_07222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40664">
        <property type="protein sequence ID" value="OXR40664"/>
        <property type="gene ID" value="B7C42_07222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371119" evidence="2">
        <location>
            <begin position="42"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="23726" checksum="D221810043BC9889" modified="2017-10-25" version="1">MALFGRERPRHVRAMVVASAFASIAATVAVGGISAPTPAAAQTACTDVEVVVARGTSEPLGADPGLGAVVGNPVYHALAQRLSSSHSAYRVDYPAGLVEPWSVQQGNRDLVKHVTDAAKACPNQRFVLVGYSQGANVVDNSIGISSVGAKVGGPIVATLPASVAPKIAAILLFGNPIRGIGHSVTGPYAGRTYDTCTANDPVCDPKGTSWKVHRTSYTAEAGEAADFAAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVT5</accession>
    <name>A0A231GVT5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40747">
        <property type="protein sequence ID" value="OXR40747"/>
        <property type="gene ID" value="B7C42_07171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="545" mass="60810" checksum="7624A328F43861BA" modified="2017-10-25" version="1">MTIALPATVKTYLYRPLTMFTPLDTDVDRVLPHLFEVCVKGGRPTRIMTDPKDFDGYLDRLIGSEAMVGFDTPDARALLEGWLRSCIVDMGTIGKSRSTEQMLAVAPITLAAYRAGVPATRSRHRYIDEVTYQLLRAQVAQRAPANPDRRLREIIETTLGHGIRIGPEPKWEPELVDPSELDISALLEFRFLEGFEMGNVRALKPDAQALNSPLPEVTDRIGAMLLDHLHVYSGRLPTAALMSTFAGLLALNIFTLTLRLDTHGRDLLGGGGRTGSSETAPPELYCDFTGGIDDESDKLSRLCVERDLNQLRLAFRDRMTFLIVDKAAERMPGEPDRLAELDAAARLRRLAELQTHPKVELVAMSQFDEIKAISTADSDAITEDESAFLDRVQQSDKSELDKLLDVLDYVNQDKATRNTVGWFSSVGGIHKPYGILRGTVRSRQSWRYAPTDELLNILLLTIFVRNSSGYRPTMPMQTLLAQLYERFGILIDRPPHFLDGAEARAAAANNVAAFKRRLQLLGCFDSLSDDFSEQIVRHPLGDRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVW9</accession>
    <name>A0A231GVW9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40770">
        <property type="protein sequence ID" value="OXR40770"/>
        <property type="gene ID" value="B7C42_07194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="30054" checksum="E8860DA3B7ED88A5" modified="2017-10-25" version="1">MRVFVTGGTGLIGTAVVAELLGNGHTVLALARSDASAAAAEAAGAEALRGGLGDLDVLRAGVAQAEGVIHLAFGNNFSSAEALAATVAEESAALATMGEALIGTDRPFVTVSGTPRAEGRASTEADPVPTDGPVGGRGRAVTAVLDLASRGVRSTAVRMPRTVHNEGRGGFAGLLTNIARRTGVSGYPGDGTQRWPAVHALDAAVLFRLALERAEAGTCWHAVADEGDRVRDIAEVIGRQLNLPVESVPADTYEPLGPIFAADQPASSAHTREVLGWEPKHPGLLEDLTNIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW78</accession>
    <name>A0A231GW78_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione transport system permease protein GsiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiC_4</name>
        <name evidence="6" type="ORF">B7C42_07018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043662.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40883">
        <property type="protein sequence ID" value="OXR40883"/>
        <property type="gene ID" value="B7C42_07018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="108"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="33780" checksum="2E062A6A45B37429" modified="2017-10-25" version="1">MTTATTGRVLRLPLDLRYLGRRVLTGLLAVWGAITLVFFALYSSGNPAIMLIAPDAPAGELERVSRLYGFDRPLPEQYARFLLAMITGDFPKSLRYNDDPLALALNRLVPSATLGAAALLFGIVVGGAIGYVAATSRSPLLRRLPVSAATVLDAIPGFFLAVLLVLVFSVSLHLLPSRGSGTPAHLVLPALTLGIFFVPSISRVFRTALVEVLDADHVRTARAKGLHPVRLTLRHIVGNSLGSTLNVLGIQAGVLLGGAVVTESIFSWPGVGQLSVNAVQNRDYPLVIACVLVIAVGFVVINLVVDILAALFDPRIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX91</accession>
    <name>A0A231GX91_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41185">
        <property type="protein sequence ID" value="OXR41185"/>
        <property type="gene ID" value="B7C42_06781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12501" checksum="90CC3A8A100284A2" modified="2017-10-25" version="1">MSDIHPEVQAALDAARDLRHKIADLREKIDAIRARRPSPSGAVIPEVDAMGRLTDLYLAPGTVDRFESHELVAEIIAAIRESSADAGRQYELLMAQDPWGDASDASQPAVPEQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXE5</accession>
    <name>A0A231GXE5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ribonucleotide transport ATP-binding protein mkl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mkl_6</name>
        <name evidence="6" type="ORF">B7C42_06674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41276">
        <property type="protein sequence ID" value="OXR41276"/>
        <property type="gene ID" value="B7C42_06674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="36696" checksum="04E0C8D5462CAA09" modified="2017-10-25" version="1">MSGVEVAVQGLTKSFGSQTIWRDVSLTLPRGEISVLLGPSGTGKSVFLKSLIGLLRPEKGSIVIDGTDILRCSSKELYEIRKMFGVLFQDGALFGSMDLYDNTAFPLREHTKKSESEIRDIVMEKMELVGLTGAETKLPGEISGGMRKRAGLARALVLDPQIILVDEPDSGLDPVRTTYISQLLMDINAQIDATILIVSHNINLARTVPDNIGMLFRRELVMFGPREVLLTSDEPVVEQFLNGTMIGPIGMSEEKDEAQMAHERALVEAGHHAGGVEVIAGVVPQMRPTPGMPPRQGEFRRQDRVREILPSLPPAAQSAILESMTEEEYVPPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXH5</accession>
    <name>A0A231GXH5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranial dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">geoB_7</name>
        <name evidence="5" type="ORF">B7C42_06686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.86" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41288">
        <property type="protein sequence ID" value="OXR41288"/>
        <property type="gene ID" value="B7C42_06686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="14"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="479" mass="50235" checksum="4769529EDB540CC3" modified="2017-10-25" version="1">MTIDYTDLYLDGRWVAPATSSIIPVISPATEERIGSVPEGSEADIDAAVAAARAAFDDPAGWAQWDGKRRAEVLAEFAEKLQERGEDTARRVSSQNGMPIGLARQFESGFPALLLQYYGSMVADQEDEIRPGMLGGSTAVTRSPIGVVGAIVPWNVPQAITFLKIAPALAAGCTVVLKPAPETVLDAFLMAEAALAAGLPAGVLNVVPGGRELGAYLVGHPGVDKVSFTGSTAAGRAIARTCGDLLRPVTLELGGKSAAIVLDDANLAADIESFFGATLLNNGQICWLCTRVLAPAARYDEIVDTITDLAKSITVGDPLSDATQMGPLVSARQRERVEGYIAVGRKDGARVTAGGGRPSDRGWFVEPTVFADVRPDHTIAREEIFGPVLSVIPYADEDEAVAIANGSDYGLGGTVWTADADRGARFARRIASGTVGINGYSNDPTAPFGGIKNSGMGRELGPEGLSSYQNVKSIYLDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXK4</accession>
    <name>A0A231GXK4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor PaaX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">paaX</name>
        <name evidence="3" type="ORF">B7C42_06639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41241">
        <property type="protein sequence ID" value="OXR41241"/>
        <property type="gene ID" value="B7C42_06639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="280" mass="30954" checksum="7B0D07A3DA3EB144" modified="2017-10-25" version="1">MTDADPPTSTKDAPSTRSARSVLITVLGELVEPYGQPVRTAALLYVMKGLGFGAHAGRQAIARTGSSGLIAARRDGRETLWTLTDKAHRLFTEGDVRVFSTDIDTTQWDGRWLVVNVPIPESHRSTRKKLYAALRWAGFGNPTPGVWVTPHTGRAAEAAKAIDALGLTANTVSFIGTTAAAGISEEELVRRSWDLDAAEDAYAALLERFDSHTFGSDDELLFNHVELADALRRMTYVDPRLPEVLLPDWRGQRAAKRLRDLRAEWTPAAHTRWRDIARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYA7</accession>
    <name>A0A231GYA7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxybenzoate 6-hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.24" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41511">
        <property type="protein sequence ID" value="OXR41511"/>
        <property type="gene ID" value="B7C42_06403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018669">
        <property type="term" value="F:3-hydroxybenzoate 6-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="46282" checksum="C4837157DC704A28" modified="2017-10-25" version="1">MSTSDVVIAGGGIGGLSTAFALSRLGLRVRVLEQAEQFGEVGAGIQLAPNCTRILAEYGLLEQATARGVVPDRMVMRDAVDASELTALDLRDLERRYGFPYLVIHRSDLHALFLDACRDAGVELLTEQRVTAYTQDGEKASATTDSGAVHEAPVVIAADGLHSVARRRFADDRPVSSAYVAYRGTVPIASVDRPVDLSEVVVYVGPRCHFVHYGLRGGDLLNQVAVFESPKALAGLADWGTPDELDDAFAGTCEFVRERLPHMWRDKWWRMYDRDPIDTWVDGRIALLGDAAHPPLQYLAQGAIMAIEDGWVLAEHARRRRGAGATVDWEGALAAYQAVRPEHCRRVVLTARAWGELRHLDGRRREQRNILLRARETGDYSFTDWIYGPTALVPEEEPAMFTPIPLTAADRITGVDSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYD0</accession>
    <name>A0A231GYD0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Soluble epoxide hydrolase</fullName>
            <ecNumber evidence="5">3.3.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41617">
        <property type="protein sequence ID" value="OXR41617"/>
        <property type="gene ID" value="B7C42_06258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="373" mass="41646" checksum="B7BB57B992BD6281" modified="2017-10-25" version="1">MAAEPFEVSVTEAEIADLRERLRRTRWPEPEPVDDWSQGLPLAYAQELCRSWAEDYDFGFAERLNVFPQYRDTIDRLGIHFLHVRSPEPDAFPLVLTHGWPGSVLEFLEVLGPLTDPRAYGGDPADAFHVVAPSLPGYGWSDKPSTTGWGVDRIARAWDTLMVSLGYERYGAQGGDWGSAVSGALGEVAPERVAGVHLNMGSVAAGTFDDPTPAELANLKAAKEFRRTGQGYSAIQATRPQTLGYGLTDSPAGQATWIAEKFWAWTDNNGHPEDAVSRQQILDEISVYWFTASATSSARLYWESFAAFRDKVTAPSGLSVYPRDLTRPSRREAELRFTDLRWFEELPRGGHFAALEQPESLVEQVRGFFRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYQ1</accession>
    <name>A0A231GYQ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="6">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crt_13</name>
        <name evidence="6" type="ORF">B7C42_06071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780859.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41729">
        <property type="protein sequence ID" value="OXR41729"/>
        <property type="gene ID" value="B7C42_06071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="26864" checksum="CA7CFEFD8C0CD5B5" modified="2017-10-25" version="1">MVEFVSVRIERSGPVFTVILDRPEARNAVDGPTAQALAAAFREFDADETAAVAVLWGAGGTFCAGADLKSLGTEKSNRAAEDGDGPMGPTRMTLTKPVIAAVSGYAVAGGLELALWCDLRIAEQDSTFGVYCRRWGVPLIDGGTVRLPRIIGHGRAMDMILTGRAVAAPEALQMGLVSQVVAPGESRAAAERLAAELAALPQTCLRSDRMSALEQWGLDESEAMAREFRYGVTALADGALEGAQRFAGGAGRHGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYT6</accession>
    <name>A0A231GYT6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41742">
        <property type="protein sequence ID" value="OXR41742"/>
        <property type="gene ID" value="B7C42_06084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045931">
        <property type="entry name" value="DUF6350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19877">
        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="568" mass="59221" checksum="C4D205B8A9146901" modified="2017-10-25" version="1">MKSALVRWADLREQRAGTRPARARPNADAPRQRSGHGGTGADGPEDPVFLSLSPERAKVLLVIAARASSFTVVAIVALVLITLMAAGSGMTGASGAIAAGWLAVHQVPVVVGKTSLGLLPLLPTAGVLWLTMRDCAHAVSPRSSRADLGWIVGAALAGPLLVTAVCLAVAEDAATAVPLQSPDTLTAFCCVGGLHLLAAVTGIAARPNALRDRIASSLPDWVFAGARAAARALWRLLLGGAILTLVSFVLHWSVIGDTYATAGNFAGLVGLTVLSLAYLPNVVIAATSFLIGADVHIGGGALSAFSVAGAPVPALPVLAAVPTGPAAGWWPVLLLVPAAVGVRGGLDCARESADEVRSPWATVFSAALAALALLLLGLFAGGTVGSFGEIGPGVLLTAGLTFAWLTVAGYLGLLCGRRFLGIAPAVVEVDLGGRRGRYLPTDYSHDEYDEDDRDEYREHGYDPRPATDRDDYYDDRAEPGYIDQLYDDPRYVEYEFEDDVAVEDDYPRPAYRRTVSTEVVEVDGELLDDDLAPAHADPDAEFDAGNSDIVDAEVVEGDLPESPGRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZI3</accession>
    <name>A0A231GZI3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein AfsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">afsR</name>
        <name evidence="4" type="ORF">B7C42_05946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41962">
        <property type="protein sequence ID" value="OXR41962"/>
        <property type="gene ID" value="B7C42_05946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="32464" checksum="10CFDA26D91E7748" modified="2017-10-25" version="1">MSNPVYARVLGPLTLALDNRNATPTAQKQRQLLALLLIRHSTVVPVTTLIEELWNDDPPRSAITVVQTYVLGIRKKMAQYLEVDQGEIADRYLRTWSKGYMFDAQDCVLDLRDYRTMTDAARCALNAGDDVRAVDLFTAAEALWTGPALLDVECGLPLSAELSHLEQVRLTDLELRIEAQLRLGRHREVCPDLARLTAEQPLHERLQAYYMYALCRSGRRHRALESYHEFARSLQRELGLDPCVKLRRLHSDILNASDESVTLMLESRHAGYLIGWQAGAQRSATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZN4</accession>
    <name>A0A231GZN4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadA_12</name>
        <name evidence="6" type="ORF">B7C42_05667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777767.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42068">
        <property type="protein sequence ID" value="OXR42068"/>
        <property type="gene ID" value="B7C42_05667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="274"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="41803" checksum="5EAB8E5B24D6B6A9" modified="2017-10-25" version="1">MNKPTGRDAVIVGAVRTPIGRGRPGKGYYRDVHPNALLGKSFSAVLDRSGVDPAQVEDVIAGCVQQIGVQGCNIARNAWLQEGLPVEVPATTLDRQCGSGQQAVNFAAATITAGVNDVVVAGGVEHMGSVPFALGVQIQNTFGMAVTPALIERYGVIENHNLVGQGIAAEALVDMWKLSRTELDELAVRSHALAQRATENGEFDREIVEFTVDGVTHRTDEGIRPQTNLETLGTLEPVFRAGGTTTAATSSQVSDGSSAVLLMSADKAGALGLAPRARIVDQAVVGVDPNRMMLTGPIPATRKILERNGMTIDDIDVIEINEAFASVVAAWSRELKPDLERVNPRGGAMALGHPLGATGARLVTTLVHELEDTDKEFGLVTMCCGGGLGTATLIQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZW0</accession>
    <name>A0A231GZW0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-reducing hydrogenase HoxS subunit delta</fullName>
            <ecNumber evidence="3">1.12.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hoxY</name>
        <name evidence="3" type="ORF">B7C42_05753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.12.1.2" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42154">
        <property type="protein sequence ID" value="OXR42154"/>
        <property type="gene ID" value="B7C42_05753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047985">
        <property type="term" value="F:hydrogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="27449" checksum="559E861376B9B194" modified="2017-10-25" version="1">MAVPTLAVWKFTSCDGCQLTLLDCEDELLTLAGRIRIAHFTEASSAVEPGPYDVSLVEGSVSTPEEVDRIAEIRSQSRILVTIGACASHGGIQALRNFADMGEFTSIVYASPEYISTLDTVTPIAAHVRVDYELRGCPIDRRQLLDTLCALLAGRAPDLPNTSVCTECKRRGNTCVMVADGIPCLGPVTQAGCGALCPSYHRGCFGCFGPMARPNIGALLPILRVNGMSYDDVDRVFATVAAAAPPFAERGRDEPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZZ1</accession>
    <name>A0A231GZZ1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42186">
        <property type="protein sequence ID" value="OXR42186"/>
        <property type="gene ID" value="B7C42_05785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19293" checksum="8E67722DFD983927" modified="2017-10-25" version="1">MSRWVVRTPVGIDGPPGAAGGDDLPGSVGGLGMTWDLSCDDIDAAWPGRPAAADAVALTRVAGGRVAMPGKRIKRTLLLRVRPGTEPAVVDRFEADLAAMPGHIAAIGSWTLSRADHPRWTHAWEQEFADLDGLNADYLLHPYHWTCVDRWFDPEIPDSIVDPAVAHLYRWGEGPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H007</accession>
    <name>A0A231H007_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin reductase</fullName>
            <ecNumber evidence="3">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcD_5</name>
        <name evidence="3" type="ORF">B7C42_05741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42142">
        <property type="protein sequence ID" value="OXR42142"/>
        <property type="gene ID" value="B7C42_05741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="348"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="463" mass="49571" checksum="D04DAA46F8C60446" modified="2017-10-25" version="1">MRTASLVADLVETFRAEGRIVIVGASLAGLRAAEALRERGFHGSLTLIGDEPHEPYDRPPLSKQVLQGWVRADHTALPRMRAVDAEWRLGVAATGLDRVNRRVLLATGDTVPYDRLLIATGVRARPWPNPAEGALRGVFTVRTREDATGLQAALNAHPKRVLVVGSGFIGSELASVCRERGVPVTVAERGGGPLIGPLGGVIGDIAARMQRGAGVDLRTGVSVRSLDGDSEGRVRRACLSDGTTLDVDVVVASLGSIRNVEWLQGAGLAAGFWGVGCDAGCRAFDINGVVTDNIFVAGDVARQPHVLYEYQFISMEHWDNAVCGAQVAANNMISLETERRPHLPLPSFWSAQFGVNIKGVGVCSFGDEIAFTQGCPENYRFAAVYGRRGRIVGAVTFDHGKWLPYYAAMIERSAPFPAPPPGYDRAPDPAPIPARFPDPRVPTGIPDVVLTGHDPTSRGAEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0A4</accession>
    <name>A0A231H0A4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ispH1_2</name>
        <name evidence="5" type="synonym">ispH</name>
        <name evidence="6" type="ORF">B7C42_05477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42278">
        <property type="protein sequence ID" value="OXR42278"/>
        <property type="gene ID" value="B7C42_05477"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="36186" checksum="3FC474AB7C3AAFE1" modified="2017-10-25" version="1">MSSAIPLNVGIARSADAAGAGAGKRVLLAEPRGYCAGVDRAVETVERTLEKHGAPIYVRKEIVHNRHVVETLRERGVVFVDETDEVPEGAVVVFSAHGVSPAVHESAAARNLHTIDATCPLVTKVHQEAKRFARDDFDILLIGHEGHEEVEGTAGEAPDHVQLVDGPEAVDGVEVRDENKVIWLSQTTLSVDETMETVQRLRTRFPNLQDPPSDDICYATQNRQVAVKAMAPECDLVIVVGSRNSSNSKRLVEVALNAGARASYLVDFAREVDPAWFEGVTAVGVTSGASVPEILVRGVLDLLAEHGYGEVQPVTTANETLVFALPRELRTTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0E5</accession>
    <name>A0A231H0E5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amino acid permease YhdG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhdG_3</name>
        <name evidence="7" type="ORF">B7C42_05554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42355">
        <property type="protein sequence ID" value="OXR42355"/>
        <property type="gene ID" value="B7C42_05554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="516" mass="54866" checksum="F4C70F0684D09CF8" modified="2017-10-25" version="1">MAEPTPTQDTAESVPNPRWGGLLRTKSVEQSIRDTDEPDSKLRKDLTAWDLTVFGVAVVVGAGIFTLTARTAGTVAGPSVSLAFVFAAIACGLTALCYAEFASTVPVAGSAYTFSYATFGELVAWIIGWDLILEFALAASVVAKGWSQYLGEVMGSRSPTVHFGSVEFDWGAALLIVILMVLLVIGTKVSSRVSAIAVAIKLSVIAVVIVVGLAYFKPSNLKPYIPPSQPSSTGEGLHQTLFQWLTGAGDSTFGWYGLLAAASLVFFAFIGFDVVATTAEETKNPQRNVPRGILGSLLICTILYVAVTLVLTGMVPYTDLAGNDATLATAFKLHGVTWAKNVISVGALAGLTTVVMVLYLGQTRVLFAMSRDGLLPRRLARTGRFGTPATLTIGVGTVCAVLAGFVQFGTLEEMVNIGTLFAFVLVSVGVIILRRTRPELPRGFRVPLVPLIPILAVLACLWLMLNLSVETWLRFVIWMAIGLVVYFTYGVRHSVLRSRPVSGTPAPASEGHASEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0S4</accession>
    <name>A0A231H0S4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42443">
        <property type="protein sequence ID" value="OXR42443"/>
        <property type="gene ID" value="B7C42_05645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9744" checksum="F6BD3F76442C2B34" modified="2017-10-25" version="1">MSADRTSPPVRTGKDERDSNAFSNKHDKKRHRAPNAHRIVVRDTRYDPPDARKLAEVIVSFAESLAAEHDETKHSTGIDTAEKPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0T2</accession>
    <name>A0A231H0T2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42448">
        <property type="protein sequence ID" value="OXR42448"/>
        <property type="gene ID" value="B7C42_05650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="649" mass="67572" checksum="4179D887601E235B" modified="2017-10-25" version="1">MTIDLPTHPSRNGPPRWLRRGSLLALSISVVVGIAAGPVWAAPPVPSPSSPVTTSPSVPVQSPPAASVVPGPVSPMTSPPPATAPVPAGMCTDPAGCVPQQPPDSRHGEHRPAAPEPDCGIDHISGCVVEAMDGFFRNLVSSALNPLLELLSTTLLATPDPASLPRVGQLWSSSWQITLTVYGLLIMAAGVLVMSYQTLQSRWSAREIAPGLILGMIAAALSFPLLTLAVRAANALSAAVAGNGVDPDSAGQALRQLVTSPEMVGTLGMFGLLLGLVLVVGLVALLLGYVIRVVVTIVLIVAAPLALMCHALPITEPIARWWWRSIAACLAIQVIQSLALITATRVFLSPDGWKLNGSSSNGGLINLIVSIALVGILAKVPFWMLSAMRIGSGRSLVGGMVRSYLTYKTFGMLRGASKTSTPPRPAARTKAAGKLADPYSKVETAADGQMLLPLPGLKRTNPKPKPATQTAGHAVPASPSPDMGRQLRLDLTTPSPPLPREAPRPDGQYALFYASPVTKPPAGRHPPGASAMGVGTTPARTAGTAASTPPGSKRAPKGRQLALRFPAAQPAPAVSAARPADPYARPKATVQGQYVLPLDVRRVRRAAPTPAPVWIAPPAPRPAGRQLHLPLPDLPVRRRRRPDTGGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1D2</accession>
    <name>A0A231H1D2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome-associated ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbbA</name>
        <name evidence="6" type="ORF">B7C42_05451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42673">
        <property type="protein sequence ID" value="OXR42673"/>
        <property type="gene ID" value="B7C42_05451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="30826" checksum="9CB16A941935F85B" modified="2017-10-25" version="1">MTPHDPPAHHPGPAIDCRDLTHRYGDHTVVDHLDLRIERGEIFGLLGPNGAGKTTTIRLLTTLMPIQHGTVDILGFRAGRHDTDIRYNLGYVPQQLSIEATLTGRQNVTWFARLFDVPRRERRHRVTEALDAMNLLDVADRLAAGYSGGMIRRLELAQALVNRPALLILDEPTVGLDPIARDSVWERVHDLRTRFGTTVLLTTHYMAEADSLCDRIALLHKGKLRAAGAPADLKAALGPHATLEDVFRHHADAGLDDDPTTEGGLRGVRSTRRTAQRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1N6</accession>
    <name>A0A231H1N6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42760">
        <property type="protein sequence ID" value="OXR42760"/>
        <property type="gene ID" value="B7C42_05098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="130"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="467" mass="50785" checksum="3D9AC70610528A86" modified="2017-10-25" version="1">MTSGPRHTERAAAAMILRSEERKKDLRRWLSDTAPFPGLSGRRYDGVLDAYHGETGFEIDPAAARALRRAWNDLAPHRIRRRGLPDYDKRQPLEVRESAAARLFDRLHRPADGVAGVRVRPDEVVVCPYSSMLMLEEVIATVVRPGGVIVCPEGFYKNFATHIAKFDVRVVVPAATPDDSFRIDPTALARELARHGDAVCAVLLTLPGNPVVTRYSPDELREIAEVLVAAEVPVICDMAFDRLVGGHIPLAALEVPTARGSVRLYDRMVTVTGNSKGYNAFGPCKLGAACTGDAQWLERIRARLTIAFQRESTHLVRAVLDHTPDAYFEHNRKLVREQFDTALDRIAAIDAEFGAKILRPLGSGASMFLSVVADSALLDAAGVGDSAELEDLLLAGAGLDSVALGRTGSPRTGVRLNVLAPRRGPGTESRELVDELFDRLGGLVAELAGGATYRDILRRRGLAEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H280</accession>
    <name>A0A231H280_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carn_acyltransf domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_04834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42948">
        <property type="protein sequence ID" value="OXR42948"/>
        <property type="gene ID" value="B7C42_04834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="PTHR22589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carn_acyltransf" evidence="6">
        <location>
            <begin position="15"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="604" mass="66263" checksum="44F20823C3A61EAE" modified="2017-10-25" version="1">MTDRTFAFDDQLPRVPLPTLDDSCARFLQWSRPLLSEDEYADTERAVADLLRADGPARILHADLERFDSSPGVGSWLDEFWPSRYLGRRDRIAVNANFFFLFRNDTPLAQSTSDQQAERAAALITAAVNYKLLLDREEIPPVVQRGAHFSMAQNKFLFSETRIPGDPQDSVRVPYSDDWPGPSQARHIVVFHHGAMFRMEVIGAGGAPHAPEDLADGLRAVLKAAPEQLPVDSSAGHLTTMARAEWAGVRTRLLGDPVNAAALESIETALFCVCLDDVTPADQLAASDQLLHGDSGNRWFDKAVSLIVFADGSAGINVEHCGLDGTTILSFVDRLLEAPVAEHAAQSGAQPQGLPSVEPIEFRLDDRLRGEISSAAAAFAQFVADNATTTVSFDRFGTGRAKELGISPDAFAQLSYQLAHQRSKGMIGATYESIATRQYRNGRTEAMRVVTPQILEFVASMDDSSADAATKLAAARAAATAHVERAKQCQRGEAPEQHLWELQWVQRRRGAELGATEPMPFFDSPGWIITRDDYLSTSSAPSANIEYFGFGCTSQKCIGIAYVLLPDRWNIYLATPKSVAEQMYRFADELRRAVSELEELLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H293</accession>
    <name>A0A231H293_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42963">
        <property type="protein sequence ID" value="OXR42963"/>
        <property type="gene ID" value="B7C42_04849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013496">
        <property type="entry name" value="CHP02680"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02680">
        <property type="entry name" value="TIGR02680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="732"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="862"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1407" mass="152293" checksum="381736F836BB784C" modified="2017-10-25" version="1">MDLIHGGVRFIPTRAGIVNLWDYRDQEFCFADGRLVLRGPNGSGKTKALEVLFPFVFDGRIEPRRLNPFAGEERTMKSNLLYRKQDSAYSYVWMEFARGRWSEPEVVTVGIGMRATRSSDKVTRWYFVADGRVGVDFSLIGPDDRPFTRKQLAEQIGTDAIVDRPVDYRAAIDARMFGLGVQRYDQLINLILTLRRPQLAKNLDPRGLSQALTDGLRPLDDQLILDAARSFSDMEEVGRTLEGLVAADSATRTFVDVYRKYLAVQAKSDVDQVRSRLDAVTHGSTALFAAAALRQRRESERTAAEHRGDEADRAYEQALTDRETLQRSSAYEGKQQLDDLADAVRRLETSAAVHRDKATKAQQAADQRGDEYERATAAVATAAAALARGEDELRAAAEEAGIAWAALPEQARAEQLTTTVRSHAEERDADVRAVRQAMTVADAAAADRTRAERTVERAGRHRDTATAELAEAEAAVALARANTAASLRNWWDTHRELFSPVAAGLFEALDAALAEAGGDDAPPLPQVLAERSDSLTETLRDRRRQARAAADQARDRAAALRAEEQRVAAEQDDAPRAPQSRTDSRATRAGAPLWRLVRFADDVDAERAAGIEAALQAAGLLDAWVAPNDEVPQDDSDIYLTSLPPTARPGGPTLAQVLVVEDGVGDDSDSPIAAVSRTHLADILASIALSDSASPASENLVAVGGDGGFRQGVQLGRHHKSQAEFIGATARARRRERRLAELAEEIAAAEQAEQSARADADEASGELARLAAAAKELPRSGAVIAALRSVSEAAGVLRSHTEAAAQAERDLDQAVSAFTAADKKVRAIAAARNAPRDPAELDALAAAVRHFENTGTALLRLRGDQQREAERAREANDRLAESRDLAEAFAEEAEAARAGYEEQLRKLETLREALGADAADIDRELEQARERIDAARAEQRAARKAAAEAIEAVGSAEGAYRAAHESLGTALTELLTDVRHLAPYARPDLLSLLGAPTESRWPSSPAAWSTADQLLYRIESGGPEGETAVLPVEVHELFDNLCAATASVRAGESARKSTRSAVTAALQEFDAALASARQDYRLQWDAADGLTVVQVHDDNGMAALADFADRIAAARADQELLLTDAERRILEDALLTGLAQQIHERTCDARDLIARMGAEMKQRRMSSGNTIGVHWVLADNLSESARAVCKLLDRAAADLGPGELATVRAHFAAEIRAARAAHPERSYPEILATTLDYRTWRVFSFTLVTADGSEDRLTVARHSALSGGEQSVSLHLPLFAAAHVMLDSADPQAPRLLALDEAFAGVDDNGRSELLGLSVDFDLDLFMTGYDLWITYDHVPACAHYDLAHSAAENTVSATLLVWDSSALLAEHDGSDLTTALGSPNRRRTPHTVEGGITFDEALELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2B1</accession>
    <name>A0A231H2B1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778435.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42985">
        <property type="protein sequence ID" value="OXR42985"/>
        <property type="gene ID" value="B7C42_04871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="203" mass="23063" checksum="1ECC8FA754E27F1F" modified="2017-10-25" version="1">MTGRPVSVEECERLWKAWTPSEVAERLSGTPPCWYVAAGWALDLFVGGLNRAHSDLEIGIPPERFDDIAAAFPGYEWDVVGDGHAWPFPEEAGNHHQTWLREPATGLYRLDVFREPHSGDRWVCRRDASITLPHEELILHTADGIPYVIPEVVLLFKAKARRAKDEADFLHALPAMDTSRRSRLSEWLSRVHPGHPWLETLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2E2</accession>
    <name>A0A231H2E2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methenyltetrahydrofolate cyclohydrolase</fullName>
            <ecNumber evidence="2">3.5.4.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fchA</name>
        <name evidence="2" type="ORF">B7C42_04901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.9" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042686.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43015">
        <property type="protein sequence ID" value="OXR43015"/>
        <property type="gene ID" value="B7C42_04901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FTCD_C" evidence="1">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="22019" checksum="51E379E95A3FDDBC" modified="2017-10-25" version="1">MSQDTASSPDTTTFGESTIGRYLDDLAAKIPAPGGGAVAALHAAQGAALVAMVARYTTRAKDADNRPAIDRIIAAADAARERALALADADATAFTAVGAAYKLPKDTDEQIAARKEAIASALLQAARVPAAVVAEADEVLSLAADLLPIGNPNVVTDIGAAADAARAAAASSQLNIAINVGSLGDHEAEEFAPALQRIEEIFARADALHTDVLAAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2G0</accession>
    <name>A0A231H2G0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">folD</name>
        <name evidence="9" type="ORF">B7C42_04903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43017">
        <property type="protein sequence ID" value="OXR43017"/>
        <property type="gene ID" value="B7C42_04903"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="124"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="28138" checksum="04C969EE08817904" modified="2017-10-25" version="1">MDTLSLTGKQLAADLNTETKNRAAALAEAGAAPRLVLVVANDDPASGWYVNSLQRAAGRLGIDCETTDLGAQASAAEIRDALAKLSEDPAVHAVMLQTPLPAGVELNDVSSAIAAAKDVDGVSPLSLGLLAAGLPGFPPATSQAVVELAKHHDIALSGRHVAVVGRSNVVGKPLAQLLLAENATVTVCHSRTTDLPAVTSAADIVVAAAGRAGLIGGDHVREGAVVIDVGTNEGPDGGIVGDVDAASVEGRAAALSPVPGGVGPVTTALLMRHVVEAAEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2I8</accession>
    <name>A0A231H2I8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43047">
        <property type="protein sequence ID" value="OXR43047"/>
        <property type="gene ID" value="B7C42_04933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="23237" checksum="A22072091EC3AC44" modified="2017-10-25" version="1">MTNAEWGAVDRYVVDTLVGDADSDVAQANSEAGLPPIDVSPAQGKFLYLLALSAGVRRVLEIGTLGGFSTLWLARAVGPQGSVVTLEYDPHHAEVARANLDRKGVGERVEIRVGAALDTLPGVAEDHGEPFDLVFIDADKVNNANYVRWALRLTRPGSVIIVDNVVRRGALADGDPGDPAVRGAREALGLLADEPRLEATVLQTVGSKGWDGFAYAVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2S4</accession>
    <name>A0A231H2S4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43144">
        <property type="protein sequence ID" value="OXR43144"/>
        <property type="gene ID" value="B7C42_04566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="205" mass="21578" checksum="94B0D3D658E27B3F" modified="2017-10-25" version="1">MSRWIIGARPPLHVALELAGAGHHEAAASDSYAGGPDEWLNLTTADPAQRRPSSIVRIQAPDLAAAQQQTARIKAAAAGEGYDSSAVIVLVDVEVMIAHDAPTARRELARLDCRLTAPSVPASLRYVGTPAGLAGLISDIHAVHVADGVTLQPLVNSEVLGHIAFRTLPWLESSGAPLSAQQVAVVRRRALRARTGRGADHRQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2S9</accession>
    <name>A0A231H2S9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pknK_5</name>
        <name evidence="9" type="ORF">B7C42_04568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43146">
        <property type="protein sequence ID" value="OXR43146"/>
        <property type="gene ID" value="B7C42_04568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016236">
        <property type="entry name" value="Ser/Thr_kinase_PknK_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000574">
        <property type="entry name" value="Ser/Thr_PK_PknK_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="75"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1199" mass="130616" checksum="EF58587229998761" modified="2017-10-25" version="1">MASVVVSISRVGRARSGMLAVRPQADRTSAGAVDHFRSRAVRVDVGRWGRSMVSFDRAQRDLTEPIAAELESAGFEAVAPIGRGGFGVVYSCEQSALQRTVAVKVLTAELDSENCSRFLREQRAMGQLSVHPHIVSILFSGTLSEGRPYIVMPYHPLRSLQERIEREGPLPWSDAVRIVIKMAGALETAHRAGVLHRDVKPGNILVNDFGEPELADFGIAHVSGGFVTTSGIVTGSPAFTAPEVLRGQPPTIASDVYGLGSTLFCLITGHAAFERRTGEKLVSQFLRITSEPLPDLRVHGIPDDVCDVVEQAMSESAGDRQSSAAELGGQLRATQRRHDVPVDRMVLPAGAEYEGAEKNSTIRASAVPRLTAGAPVSRRAAPCTPPAASTKFRPPSSARPLVVRQRLFEQLRAGQRRRLVVIHAPAGFGKSTLASQWRDTLTRENVRVAWLSIDQDDNNAVWFLAHLVQALRTVSPELGEKLERLLELHGDAAQPYVLSALVDGIHTAAQPVALVVDDWHRVTDGATISALGYLLERGCHHLQVIVTSRSRTGLPLSRMRVHDELVEIDSNTLRFNTSEARSFFAGAGGLALRPADIAHLTASTEGWVAALQLAALSLRNADDPSDLIDHLSGRHHAIGDFLAENVLDGLEPRLLEFVLRTSITERLSGSLASALSGMPDATALLEEVEARDLFLIRSDTDRDWFRYHHLFAEFLRRRLERDHPDWMTDLHRVAYRWFADHQFLREAVDHALAAGDEDWAVEKVERDGTQLLEQSQMPTLLAVIQKLPPLTVTTNPRLQLAKVWANLLLQRRDSANAALAQVRSLLRNNRGVRDDTVEIEADVVEAAVRVSGDRLGGVAELVAGALNRPEELHPWVVTTAADMDAFVAIYRFDFAAAHRRQQWAIDYHRRMRGPFSVMYGYSFDGIAANEELDTTTAEDNFRTAVRVAEQSGGGRLHAARIAGALLGDLLFDKGDIDAAERLLDEGYELGVEGGIVDSMLATFGTGARIKALRGDRDSARRRLYDGWRLATALSLPRLAARIMNECVRTGIAVPAGDPSAGVVTSSGSDDAANGIELVTAELLEESVIRELLARRSISAAAEACELARARADRLAGQQRPRALLQANLLLVGCLVAAGETERAARSLLPWARLCAQRSLIGLLRYGDPRVLTIVRRIAADSADDGSAGLPAAFVDAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3W0</accession>
    <name>A0A231H3W0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">carA</name>
        <name evidence="4" type="ORF">B7C42_04425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43557">
        <property type="protein sequence ID" value="OXR43557"/>
        <property type="gene ID" value="B7C42_04425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="372" mass="39787" checksum="7F47A044B04C200A" modified="2017-10-25" version="1">MSDRAAVMVLEDGRVFRGRRFGAEGETLGEAVFCTAMTGYQETLTDPSYHRQIVVATAPQIGNTGWNDEDDESNRIWVAGYAVRDPAKRASNWRATTTLQDELERQHVVGIAGIDTRALVRHLRTRGSMKAGIFSGDAAAASTEELLSRVTGQASMLGADLAGEVSTDGVYTIEPVGEHRFTVVAVDLGIKTNTPRMFAERGIRVHVVPSGVTLDQIKELKPNGVFLSNGPGDPATQDDAVELTKSVLGEGLPLFGICFGNQILGRALGLGTYKMKFGHRGINVPVIDHTTGAVSITAQNHGFALEGEAGQRFDTPFGAAEVSHTCANDGTVEGVRLVDGRAFSVQYHPEAAAGPHDAAYLFDRFAGLMEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H428</accession>
    <name>A0A231H428_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43614">
        <property type="protein sequence ID" value="OXR43614"/>
        <property type="gene ID" value="B7C42_04482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010645">
        <property type="entry name" value="MFS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06779">
        <property type="entry name" value="MFS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_4" evidence="2">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="387" mass="38815" checksum="4E60BC377FDBAE3B" modified="2017-10-25" version="1">MTIALPRQASLAPALRASAGLAAAMGIGRFVYTPLLPVMIDAGRFGAHTGAIVAAANYAGYLLGAVALARFPEYNGGTAFRISAAALVTSEAAMAIPAPAILPIILRTVAGVAGAVLFIGCAQIAARHENRRRAAGIAFAGVGTGIAATGALVLIAQSVLSWQALWLAAAGLTALLLWPALRLEVVAGSRTGPATVRSARSWRLLQTTYFLEGLGYIVLGTFLVAAVGATGHRTAGTAIWIVVGVAAAPATVVWSLIARRATPVIALVAALVLQCLSALLPTLSAGVWPAVVSAALFGATFMGITLLALEIGDDLAGPGAAATLTAGYGLGQMLGPLVVAPVLGDSYGAAFTIATLILAVAAVTAIAIGSGRRHDPAAAAPTPIRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H450</accession>
    <name>A0A231H450_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43600">
        <property type="protein sequence ID" value="OXR43600"/>
        <property type="gene ID" value="B7C42_04468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="38518" checksum="F4E4310E04EDD4BD" modified="2017-10-25" version="1">MTDADHRDDTSSSEESEKPGDSADPTLVALGGGHGLYATLTAARRITERITAVVTVADDGGSSGRLRSELGMLPPGDLRMALAALAEDPDGIWARTAQHRFGGTGALAGHSVGNLVLAGLAEVLGDPVAALDEMAAILRCTGRVLPMSPTALTIEADVSGLEADPRVSRCIRGQVAVATTPGKVRRVRLIPSDPPASPEATSAIEHADVVVLGPGSWFTSVIPHMLVPELREALMHTRAVKVLVLNLAAEPGETAGFSAERHLHVLSQHAPDFAVDHVLVDSGSVPEGREREHVARAAEQLRARVTFADVAEAGTDRHHPGKLAAALDQVIRQPRPELAGLRVEGRHPVQQVRSVLGGKERVSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H454</accession>
    <name>A0A231H454_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly scaffold protein IscU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iscU</name>
        <name evidence="2" type="ORF">B7C42_04512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502476.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43644">
        <property type="protein sequence ID" value="OXR43644"/>
        <property type="gene ID" value="B7C42_04512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="17866" checksum="8A573B428AEB4419" modified="2017-10-25" version="1">MRMEQMYQEVILDHYKHPHHRGLREPFGAEVHHVNPTCGDEVTLRVHIDDNGDVADVSYDGQGCSISQAATSILTDQVIGQPVQQALKVVDSYSEMISSRGTVEGDEDVIGDGIALAGVSKYPARVKCALLGWMAFKDAVVRITSAEETKRTMGNGSAGNGEAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4J3</accession>
    <name>A0A231H4J3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_04504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778882.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43636">
        <property type="protein sequence ID" value="OXR43636"/>
        <property type="gene ID" value="B7C42_04504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004377">
        <property type="entry name" value="ABC_transpt_DrrB/DrrC"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00025">
        <property type="entry name" value="Mtu_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="27685" checksum="F80BDF803717B85F" modified="2017-10-25" version="1">MTRTAPRFTPGTFSPAPRPAPRLAMLAAQTRMELILLLRNGEQLLLTMFIPITLLIGLTLLPLGSSLGEHHKVDRIVPAVMMVAIMSTAFTGQAIAVGFDRRYGALKRLGATALPRWGIVGGKCAAVLIVVVLQSVLLGLIGVALGWRPGIGGLALGALVIALGTATFVAMGLLLGGTLKAEIVLALANILWFVMLGVASLVFASDNLPHAVTLIARLIPSGALAEALDQALHTSVDWYGIAVLVVWGVVTGWLATRWFRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4K0</accession>
    <name>A0A231H4K0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_8</name>
        <name evidence="5" type="ORF">B7C42_04064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43829">
        <property type="protein sequence ID" value="OXR43829"/>
        <property type="gene ID" value="B7C42_04064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="35916" checksum="D52B0EAC983E5665" modified="2017-10-25" version="1">MTSNAPADALAIEADGLVKVFGEQRAVDGVSLAVPQGAVYGVLGPNGAGKTTTIRMLATLLRPDGGRARIFGHDVVAEPTAVRSLIGVTGQYASVDEKLSATENLIIFSRLLGLSRSQAKRRAAELLEEFGLTEAATKALENFSGGMRRRLDLAASLIATPPLLFLDEPTTGLDPRTRAQMWETIRRLVREGATVLLTTQYLDEADQLADRIAVIDHGRVIADGTSDELKGSVGQSALQITVADRATIERARTLIGEFLSRADGKLVEASISPEAGRVTAPLSDPSVTADLLIRLRDNDIRVDEITVSKPSLDEVFFALTGHAAESEDAGTDSEDTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4P7</accession>
    <name>A0A231H4P7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781146.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43834">
        <property type="protein sequence ID" value="OXR43834"/>
        <property type="gene ID" value="B7C42_04069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="14496" checksum="CB8F3D053DE872CC" modified="2017-10-25" version="1">MDILSSRIILRPSDYERTLAFYRDGLELAIAREYPGGTVFFAGQSLLEVAAHGRDEAAPAGFAGAVWLQVRDANIAATELAIRGIPIDRAPVREPWGLIEMWLRDPDGVPIVLVQVPADHPIRRDSRKPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4X2</accession>
    <name>A0A231H4X2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43842">
        <property type="protein sequence ID" value="OXR43842"/>
        <property type="gene ID" value="B7C42_04077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="203" mass="21241" checksum="208BE638DD1CBC25" modified="2017-10-25" version="1">MSSDTAAPGSVRPGGRTARVRESVLRAAGDLLAEQGFAELDLAEVAARAEVGKTTVYRRWRTPAGLVADMLTDMAETSLPHADTGSLRGDLTANARLVARTLTDPRQGPLFKALVAAAVCDPETTAGLHRFYDVRITEWEPCVTAAVERGELAPGTDARAVVSAVSAPLYYRFLISGDPIDDAVAVTAADAAATAATAGLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Y8</accession>
    <name>A0A231H4Y8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781078.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43900">
        <property type="protein sequence ID" value="OXR43900"/>
        <property type="gene ID" value="B7C42_04139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="13034" checksum="C587EE73D135BB0B" modified="2017-10-25" version="1">MDWKIELVAIPVTDVDRAKAFYTSIGFNADHDASPTEDIRFVQLTPPGSGCSICIGKGITDAAPGSVVGMQMVVASAEEAYRQLVAAGVEATPVKDEGWGLFTYFADPDGNKWAVQELPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H536</accession>
    <name>A0A231H536_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-haloacrylate reductase</fullName>
            <ecNumber evidence="3">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03575</name>
        <name evidence="2" type="ORF">B7C42_08173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000071">
        <property type="protein sequence ID" value="OXR39761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783906.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000071.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39761">
        <property type="protein sequence ID" value="OXR39761"/>
        <property type="gene ID" value="B7C42_08173"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44019">
        <property type="protein sequence ID" value="OXR44019"/>
        <property type="gene ID" value="B7C42_03575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="17"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="35166" checksum="92D3B9D63C2A173E" modified="2017-10-25" version="1">MTTDAITARTVVFHELGDPEVLTIENLDLPALGPKEVLIRIEALGLNRAEALFRAGTYYYLPTLPGSRLGYESSGVIEAVGDDVTEYAVGDKVSTGPNIEMSSAGVYAERVVLPVESVVPRPEGLDAVTGAATWLTYSTAYGGMIETGGLRPGDHVLITAASSGVGIAALQTAARIGAIPIAVTRTGEKSRYLLDNGAAHVIASADTDVVAEIRRVTDGVGAQVIFDAVGGPGLAELSTAAAHNGTVVVYGWLDQRPMAMPMNWPLRILGYANMELSVTADGRRRINHWIASGIRDGVFHPHVGAVFDGLDSIRDAHRLMESSTHTGKIVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H594</accession>
    <name>A0A231H594_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783894.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44010">
        <property type="protein sequence ID" value="OXR44010"/>
        <property type="gene ID" value="B7C42_03566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="130" mass="13478" checksum="A4BB604F87A5EE5E" modified="2017-10-25" version="1">MDPVTVIVAALSVGAAKGLGDTASTAVADAYRGLKSLLVRVFGGDSKAELVLTEHESDPDTWQAPMTKLLTDTGAVVDEQVLAAARKVLELADSSGSRAGKYVIDVRGANIGAIGDRNQQYNVFGSRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5P2</accession>
    <name>A0A231H5P2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ORF">B7C42_03685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777407.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44127">
        <property type="protein sequence ID" value="OXR44127"/>
        <property type="gene ID" value="B7C42_03685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="135"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="344"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR44127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="506" mass="51578" checksum="AC8C2130CB052ACE" modified="2017-10-25" version="1">MIEMTLREIADIVGGTLHDVSDPAVTVTGAVEFDSRRINSGDLFLALPGEHVDGHDYAGKAVASGAVAVLAARPVGVPAIVVEPFASAADAAASRSYVLAHDTDGSGAAVLAALAKLARASVDRLAAAGLNVVGVTGSAGKTSTKDLLARVLAPLGAVIAPPGSFNNELGHPWTALRAGADSRFLVLELSARGPGHIKALTEIAPPRIGVVLNVGTAHLGEFGGRDAIAQAKGELVEALPPTGVAVLNADDPRVAAMAARTRARVVTFGQASGADVRATDIVLDSEARARFTLHANGSHAEVHLAVYGEHQISNALAAAAVALECGADLDTVARALAGATVDSAHRMDVRTRPDGVTVVDDSYNANPDSMRAALKALVSMSRAGGTPDAPRGRRSWAVLGEMAELGEESVVEHDGIGRLAVRLDVDRLIVVGTGRPARALHQGAVMEGSWGEESILVPDIESAIALLDNEIAAGDVVLVKASNSAGLWAVAQHVLASGEQGTEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5P6</accession>
    <name>A0A231H5P6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44158">
        <property type="protein sequence ID" value="OXR44158"/>
        <property type="gene ID" value="B7C42_03717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="12106" checksum="13E2FC5C6D183552" modified="2017-10-25" version="1">MGTPWGPFIPVTVHNGVTFDFARVPPHITEIQPQHYALLVSEPEFDAAYAKIRDRGLPFWADPQQSREGEINHNDGGRGIYFLDPSGHYMELLTVPYGGWPAATGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5R6</accession>
    <name>A0A231H5R6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44147">
        <property type="protein sequence ID" value="OXR44147"/>
        <property type="gene ID" value="B7C42_03706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011256404" evidence="2">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="16925" checksum="FEEA35119DB7AF93" modified="2017-10-25" version="1">MTGRIAVATLAVVAALGMSACGSGDKHSSHKSTTTKAAASSAANVPPVPTVADLNSELAQALDPGVPAAQKAQWLEDGQDALAKDPEMMQKLTDAYQQNNAKINVTDVAYLGGDTLTAKVDFSVNGGAPTKADVPFVAQGNSWKLQKSWACAGLKNLGQQSPACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H674</accession>
    <name>A0A231H674_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44330">
        <property type="protein sequence ID" value="OXR44330"/>
        <property type="gene ID" value="B7C42_03891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20323" checksum="848E3A83461D9E0B" modified="2017-10-25" version="1">MTTADDALVVIPRRTRVLHTLRVAGWLAADHFGADAPLTDATLFTQVPTPRGDMITLTPAGEHAAEVELTAVCRHLSPAGRDRIVALLDRFEQADPRIKNAVTAFQRDRGPVAARGVLELHGEVADLLTAIGDALPLWDDYPARFATVVALIESGDLDSVASPLRDSYHTVWHLLHRDLRLVADCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6C6</accession>
    <name>A0A231H6C6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44405">
        <property type="protein sequence ID" value="OXR44405"/>
        <property type="gene ID" value="B7C42_03194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009677">
        <property type="entry name" value="DUF1266"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06889">
        <property type="entry name" value="DUF1266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="31909" checksum="CC8F6E9DEECA6219" modified="2017-10-25" version="1">MRHNRIMAARDMPTLTTFPYPELDEREDDHWSGAQVSDDELRALSLGAFYSARWDAFHDALLLGPEREHPLGDRRELAIDTLTGAWGITDGTEAMASMEQLLDGMHAPLYALVHPLVNAALNSPERDRFGERADRHRAFLRQVGAFRGMDNPEALVRDYDIWSQAIKLDLTGHLVQPLPADIQAWDLARVVAVARMAFTAGYLEADTAWDYVMRALPPAQKRYRNWRQFGDAYLTGWTYWQACEDMAVLKSGGTDRRLELVRLWMRPTSPWRRIALQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6K8</accession>
    <name>A0A231H6K8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775897.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44511">
        <property type="protein sequence ID" value="OXR44511"/>
        <property type="gene ID" value="B7C42_03300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="82"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="363" mass="37633" checksum="180EE421DA20FCAB" modified="2017-10-25" version="1">MSRLRTPLTELVGIEHPIVQTGMGWVAGPRLVAATSQAGGLGILASATMTYAELEAAVAKTKAHTDKPFGVNIRADASDAAERIELLIREKVRVASFALAPKKELIARLKDAGVVVVPSIGAAKHAVKVASWGADAVIVQGGEGGGHTGPVATTLLLPSVLDAVDIPVVAAGGFFDGRGLAAALAYGAAGVAMGTRFLLTQDSSVPDEVKQEYLRRGLQDTVVSLKVDGMPHRVLNTDLVDRLEHSGSWRGLSAAVANAAKFKSMTGMKWSTMIRDGLAMRKAKDLSWSQVIMAANTPMLLKAGLVEGNTQAGVLAAGQVTGIIDDLPTVQELIDRIIDDAVARIDTIAALRDGAAATPGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7I7</accession>
    <name>A0A231H7I7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dlaT_1</name>
        <name evidence="8" type="ORF">B7C42_02706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44752">
        <property type="protein sequence ID" value="OXR44752"/>
        <property type="gene ID" value="B7C42_02706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014276">
        <property type="entry name" value="2-oxoglutarate_DH_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02927">
        <property type="entry name" value="SucB_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="601" mass="61650" checksum="AE306D49FC5D9FD5" modified="2017-10-25" version="1">MAFSVQMPALGESVTEGTVTRWLKQEGDTVEVDEPLLEVSTDKVDTEIPSPAAGVLTKIVAQEDDVIEVGGELGVIGDADEASASAPAPAQEAPAQQAPAESAPAQEAPAQQAPAQEAPAQQPAPAAQSGGAADGTPVKMPELGESVTEGTVTRWLKQVGDQVEVDEPLLEVSTDKVDTEIPSPVAGTLLEISANEDDVVSVGGQLGVIGSGSPAAAQSAPAPAPAPAQQAPAQEAPAQQAPPQQQAPQQAPAKQEAPAQQAPAQQAPAQQAPAQAAPAATSGNGESPYVTPLVRKLAQENNVDLSTLKGSGVGGRIRKQDVLAAAEANKAPAVPQPAAAPAAAAAPAKPSAPAGARPQLQALRGTVQKANRIRQITATKTRESLQTTAQLTQTHEVDVTKIAALRAKAKSAFADREGVNLTFLPFFAKAAVEALGVHPNVNASYNEDTKEITYHSSVHLGIAVDTEQGLLSPVIHNASDLSLAGLARAIADIANRARTGGLKPDELAGGTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPIVISDNGSEFIGIRSMCYLPLTYDHRLIDGADAGRFLTTIRHRLEEAAFEADLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H844</accession>
    <name>A0A231H844_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45104">
        <property type="protein sequence ID" value="OXR45104"/>
        <property type="gene ID" value="B7C42_03061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="43668" checksum="F86002ABCAA0EEF2" modified="2017-10-25" version="1">MVSVPADPDTVTAVGPEDDPTAAGLRPGDVEAVWESVRAWYRMGTTPAIQICLRRHGAIVLNRALGHGWGNAPADGPDVERTPITVDTPFCGFSTAKGVAATVMAMLIEQGAFAPEDRVCDYIPEFAAHGKGRITIADVLSHAAGVPFMPAGYRGFDAVVDEDLAVRALIELRPSWPPRRLRVYHALTSGLILRLLVQRATGKRMRDHLAERVLNPLGFRWTTFGVAPEDVDRVVPSVRTGPRPSRAWSVVAGKALGGGMSASTSAESVRAFLTAELPSGNLVTTASELSRFYEILCRGGELDGVRILSPDSLRSAIAPAPRIPGIAGRVSRAGFELGGRRSKFGAHTETHFGRSGLTTQYGWADLDRGLSGAILTSGKSTVDTERPWQLCAQISAIVPRSPIARPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H872</accession>
    <name>A0A231H872_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45213">
        <property type="protein sequence ID" value="OXR45213"/>
        <property type="gene ID" value="B7C42_02338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="504" mass="56195" checksum="9655E50577E889B3" modified="2017-10-25" version="1">MAIDHEVIIVGAGFSGIGVAIALRKAGFRDFLIVDDADGVGGTWHWNTYPGIAVDIPSFSYQYSFERSSRWSRIYAPGRELKDYAEHCVDKYGLRPRIRFSTTITAAEFDEDASVWTLRTGDGETLTARYVIGATGVLTRPKLPDIPGVESFSGLTMHTSRWDHARELRGKRVAIIGTGASAVQVIPSIAPDVAELTVFQRTPIWCLPRPDTTLPTPARWALRYLPGGQAISRLASQAFVELTFPLSAHYYSNLPLARLGERSGLAHLRRQVHDPAVRDKLTPRYALGCKRPGFSNDYLPTFNRDNVTLETDPIAEITPTGVRTAAGTEYPADVLILATGFKVMESGNMPTFDMTGVGGRDLEKWWDENRLQAYEGVSVPGFPNFFSIIGPYGYNGASYFTLIEMQTSHILRLLRHARGKRAHRIEVTAAANERYFREMLERRGGQVFWQDSCAISNSYYFDKHGDVPLKPMSTVEAAWRATHFDLGDYTFEQIPAQVPTTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H881</accession>
    <name>A0A231H881_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase catalytic subunit 2</fullName>
            <ecNumber evidence="1">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaE2_2</name>
        <name evidence="1" type="ORF">B7C42_03016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45059">
        <property type="protein sequence ID" value="OXR45059"/>
        <property type="gene ID" value="B7C42_03016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="15213" checksum="DE571747D987466B" modified="2017-10-25" version="1">MSEYTPLTRISDQPLQPEEVERAVTGPEHGAVVVFTGKVRDHDGGQAVSALEYSAHPEAEKFLTRVCAEVGKSAGLPVAAVHRVGALTVGDLAITVAVAAPHRREAFETCAELVDRIKHEVPIWKRQLFADGMSEWVNACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8A3</accession>
    <name>A0A231H8A3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,8-cineole 2-endo-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.156</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cinA_4</name>
        <name evidence="4" type="ORF">B7C42_02934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.156" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44977">
        <property type="protein sequence ID" value="OXR44977"/>
        <property type="gene ID" value="B7C42_02934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="449" mass="50384" checksum="01F1C0D57E8FDB76" modified="2017-10-25" version="1">MTVHADDHRQPRYDFDRHAPQYRDNFDAITSDMHRQCPLAWSPTYGGHWVAAGSREVFSLARSENVSSDHDPNGERRGYRGITIPFPETGNAIRNGILEMDPPEQRLWRQALNPYLSPAAVQRWVPFVDEVVRASLDDRIESGRIDFVDDLANIVPAVLTLAMLGIPLRKWQLYCEPAHASVYTPPNSPDIERVRRQHEAMGLDLLINLTEVRDNPRPGIIEALTRLEIDGTAPPDIELLGMLGLLIGGGFDTTTALTAHALEWLSDHPDQRAILSAERELLLNSATEEFLRYFTPAPGDGRTIAADCEYAGIRLEEGERLWLSWAMANRDPELFPDPNTLDLDRKGNRHFSFGLGVHRCIGSNVARTVFKRMLVAVLDRLPDFRCDPGGAVHYDTIGVIQGMRHLPATFTPGRRLGPGLDETLETLQRDCDENRLAEPVTVRRDGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8E6</accession>
    <name>A0A231H8E6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45119">
        <property type="protein sequence ID" value="OXR45119"/>
        <property type="gene ID" value="B7C42_03076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="129"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="481" mass="49881" checksum="EF7212FFDD9262D2" modified="2017-10-25" version="1">MILDPSGRGATARQLTLAGLAMLLVVAALLYLLALRYTGRFTEKVPVHAVLTSTGDGLPKHADVKFRGMVVGTVDSVEVVAKGERQRADIALKPRVAEAIPANVTARVIPDNLFGVTAIELVDNGPDAAKLHSGSTIAQDTGAATIQLQTTLNVLRTVLSNIQPEKLGRVLATLSAALEPSARVPGSTVERLDTWLTQVHDIPDIGDLLGDLGRAATALSQSAPELVGVLSDSVTTAHTLTERRSNLVALLTNAGGAVDSVNHLFARNPDSGKFLVAGLDDLFGGLAKDPEAIPFTAANLNTALQRLKTTFHWGPKQQMVWAMDASLTPFQQYTAKDCPHYGDQYGPRCGGATVPNVAPPQEYPQQQLPRWLDAAGPRPTPAPAAAPAQQPLIPGLPALPGVPALPGLPSLPLIPGITAPAAYRTTPGDPAATRPAALRGPAAVAAVVGGPPNLAQLLLLGPVLAGGYLTVGETPEGGVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8R0</accession>
    <name>A0A231H8R0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45210">
        <property type="protein sequence ID" value="OXR45210"/>
        <property type="gene ID" value="B7C42_02335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="139"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="361" mass="39155" checksum="6C85B5CBE06D31C0" modified="2017-10-25" version="1">MDLAGISVVDAHIHQWDPLNTPRDFSMLAKLFRFVPVPVDKAARLAPKRDRDFVGIPDAYLRPYLPADYREDLGAVPVEALVHIEVEWAGRAPDAKADETRWVASLPFGVDTPALGAIIGSGDPATPGFAELVDKHQSASPLFRGIRTMVAHHPDAGVRSFCRADGALTESAFLDGFAVLAERGLSFEAWVYSHQIPQVTALARRYPEVTIVLNHLGTPAGIFGPVGKNTGTQPGRRRELFVQWRDDIATLATHPNVMAKVSGLAMPILGHPVPVRGIPTPVSELLDRTAPLLHHAFDVFGAQRLIWGSNYPVDKPITSIANGAQAVIDVLADRGGSAEELDQVFRTNAQRTYGIDAELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H947</accession>
    <name>A0A231H947_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45217">
        <property type="protein sequence ID" value="OXR45217"/>
        <property type="gene ID" value="B7C42_02342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1524" evidence="1">
        <location>
            <begin position="80"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="23726" checksum="DB913F09B9C88649" modified="2017-10-25" version="1">MVVVVMAMTACGIVGGPDPAPGSPSRARIEQLLGAVAVVARRAHPGGYDRDCGAGHGCVFGPAWSDDQDGPGGHDGCDSRNGVLARQLREVRFRPGTRDCVVLAGTLRDPYTGRSIIFDKARARDVQIDHVYPLAAAWDMGAAAWSPEQRVRFANDIEFNLLAVDGPANMDKGDRTPADWLPPAGAYHCFYAGKYLTTAAQYRLPITAADHAALARIARQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H951</accession>
    <name>A0A231H951_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein HscA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hscA_4</name>
        <name evidence="4" type="ORF">B7C42_02510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45385">
        <property type="protein sequence ID" value="OXR45385"/>
        <property type="gene ID" value="B7C42_02510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="526" mass="53904" checksum="E29500805EBBA481" modified="2017-10-25" version="1">MRTSLGISAGNEVVCSAVVATAPNGAQSFDYRVVSADVAHSDPGDLVASSIELMTTQMPRDYLHRVGTHSPGASAPQTQPVPAGAIAVAYRDREQAMAIRAAIGRQRRDVQLIPESTAALTYLRDTGLLDRYETVAVIDLGASGTTVTVADLADDTVLRSERTEAISGSAVDELIYHHLLDCHFARRGTRPNRNMLINRSRAAKEHLSIAPAVTIDHVAGQPLKLTRADFAELIADLLREAADYARAVFARAPKVPEAVAIIGGGANIASLIDGLDALLDIPVVSVPEPEAVTAKGAALVADSAQPSNFSPIALGSDGSAGTFTKVIGTLVGAVVVVGLVVGYGVKELVPTAHQDVTPAGTTDTQLTTPPAPTSMPAGTSTDGTGQSRTEHPPANSTQPGSSAPGTSPGSSLPTTNADQVTPVTPTTSAPVLRPDPNLPQIPLPPNLPHLLGPLLGTTTPQPVTPDTSTPTPGAAPTKPGSTRVPVLPRSSSGSADSDPVQPTEPGDPIPSGRSAAPGTTTVQPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H952</accession>
    <name>A0A231H952_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45379">
        <property type="protein sequence ID" value="OXR45379"/>
        <property type="gene ID" value="B7C42_02504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="295" mass="30229" checksum="C1791E37BB27AACA" modified="2017-10-25" version="1">MLDLSPRIGGLLDSGSAPVLVDAAFGARPGIAPADLPAATDPAGTWLRAVVLGGQGRYAAARTELLRAARLTRDPILGSLLASTEASLLRQLGRHARAAIPDGRAAALVANLPVGRAADPMRAAAICDALTGLAADALGTGQPQVSARLLRRCRDEIDRAPADLRILVRWHWVSAETALAAPGMGLVAEPALAHAEAAVAAAERMGSVRHQVKSRLLVAAAAAGEGDIDRSRAVAELVDSDCAAHGLLPLRWAAAMLRAGVCEPDAARRAAAESGAYAQILAGRGGRLRLGPEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H980</accession>
    <name>A0A231H980_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme bromoperoxidase BPO-A2</fullName>
            <ecNumber evidence="2">1.11.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bpoA2_1</name>
        <name evidence="2" type="ORF">B7C42_02487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45362">
        <property type="protein sequence ID" value="OXR45362"/>
        <property type="gene ID" value="B7C42_02487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="30723" checksum="3D0A8FD4E0522C85" modified="2017-10-25" version="1">MEHPTRCGDGARGDVPWLIVESNVIRVPLAGVQIAYWDSGSAPTTHPLSEIPVVLVHGMGGDGHTWDRFATALIRSGRRVIIPDLRGHGHSEHTASYRFEDFGEDLLNLCDRLELTTVDLVGHSLGGYACSWVAIERPALVRRLVLEEQPLPLRSGDEQLTLTRRLPSVPELWHATTSLLRHPRAVLAFDRSMTTPALEQFRKPHPEWWERLADITAATVMLRGGPGGMVDPEKLEIFRTSVPDCRVEAFTCGHSIHRDRYREFASVVLPFLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9U0</accession>
    <name>A0A231H9U0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC_dehydrat_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45600">
        <property type="protein sequence ID" value="OXR45600"/>
        <property type="gene ID" value="B7C42_01892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16508" checksum="E825B180FEAA2F35" modified="2017-10-25" version="1">MPIDVQAALALSFDPITVDVERGRLRLFAKAIGETSPIYTVVDAARQAGHPDLPVPPTFFYSLELETPDPFGYLAALGVDLRRVLHGEQSFAYHRPAHAGDTLTLRPRIVDVYSKKGGALDFLVKQTSISRGAEPVAEATSVLVVRNPEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAJ7</accession>
    <name>A0A231HAJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45983">
        <property type="protein sequence ID" value="OXR45983"/>
        <property type="gene ID" value="B7C42_02276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="21079" checksum="ED5C614099AD41F5" modified="2017-10-25" version="1">MSIADIERVRPERLRCRQLRMLAVVTNESGCRDATQVLLERAYRRWSGRPDCDHFPPVQRWQAIEPGYLDGAELLPGSLIGAAAAGHRPRIRDLSLGVQAALVLHSGCPAHVEETVLPGAGRGALAQGSRRGLFISVYGLPEDDMTLAESVLAGYAGLGALTVVERFSRWLPDKASHPTVSVPARAARTDPRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAW5</accession>
    <name>A0A231HAW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036508580.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45867">
        <property type="protein sequence ID" value="OXR45867"/>
        <property type="gene ID" value="B7C42_02159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7376" checksum="D61CBB07674DD3D5" modified="2017-10-25" version="1">MKIRLDRTVCDGFGTCAKHAPKYFSLDDWGYASLEGDGAVPPADRDGVHRALLDCPVHAITEIDSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAZ8</accession>
    <name>A0A231HAZ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-pyrone-4,6-dicarbaxylate hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ligI</name>
        <name evidence="3" type="ORF">B7C42_01068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.57" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46104">
        <property type="protein sequence ID" value="OXR46104"/>
        <property type="gene ID" value="B7C42_01068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047554">
        <property type="term" value="F:2-pyrone-4,6-dicarboxylate lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="33297" checksum="DABC9F7F96D64C33" modified="2017-10-25" version="1">MFDSHVHIIDPRFPLVENQGYLPEPYTIGDYRKRMAHFDVDGGAVVSASFQGTDSTFMIAALAELGPNWVGVINLPSDVTDEQIIELDRAGVRAIRFNLKRAAVDIVTLTMQAVRAYELAGWHVELYIDGSMLGSLEPVISKLPALSIDHMGMSDECLPYLLNLVDRGARVKASGFGRVSMDVESAMRRVHAVNPGALMFGSDLPGNRAGRPFRDADIEIIGRAVGADMYRVLEDNARACYRLPVKVRSAEDPVPTLPIPRAEPPTLRLRRSELPQPPNRNQPPNRDQPPDRTRPLRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB23</accession>
    <name>A0A231HB23_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigJ_1</name>
        <name evidence="8" type="ORF">B7C42_00985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043327.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46022">
        <property type="protein sequence ID" value="OXR46022"/>
        <property type="gene ID" value="B7C42_00985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="33353" checksum="F42C790C753E5745" modified="2017-10-25" version="1">MDDTGLAEFQRHRSRLFALAYRMLGSASEAEDAVQETYLRWEATERAEIRSAEAWLTTVVVNLCRSWLESARTRRETYVGPWLPEPVPTGGGELGPMESAEQRELVSLAVLTLLERLSPAERAVFVLREAFGYAHREIADMLELTEANSQQLYRRARLHVRSEHTRFDAEPARARELFQRFLVAARAGDIAALEQMFTADIVSVADGGGKMSAARRPVVGAGRVARYLAGLFHREVEDLELSIEEVNGAPAAVARVHGELLLIGAADVAGERISAIRILLNPDKLAYFGRFPAPAEAERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB68</accession>
    <name>A0A231HB68_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">pH-sensitive adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46079">
        <property type="protein sequence ID" value="OXR46079"/>
        <property type="gene ID" value="B7C42_01043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="134"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31954" checksum="28D03236B87C26DD" modified="2017-10-25" version="1">MPPVDRPGSGVGPGLDPEVEIVIPLTPADETESRLRSFGRRGSDQLSSLMAAANQRADVIGVIRKARESLPGDPAFGDPLSLTGPGGARAVARAADKIVGDNPSAAKELGLGALQVWQAMLERVGRGKGSAEITVVFTDLVAFSRWSLSAGDEATLELLRRVARAIEPPIVDRGGQVVKRMGDGVMAVFASPDSAVRAVLTAKKNLDRVEVAGYRPRMRAGLHTGTPREIGGDWLGVDVTIAARVMEAGGNGNTMISETTLEALEPSTLKELEVAAKPYRRSMFAAPLNGVPEGMRIFRLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBK4</accession>
    <name>A0A231HBK4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46238">
        <property type="protein sequence ID" value="OXR46238"/>
        <property type="gene ID" value="B7C42_01204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16477" checksum="36933FBA81636287" modified="2017-10-25" version="1">MRLKEIATPQDWADTYRELFGLPYVRVTSPGYVVLPLGDSVAAVNTPEPLGALVLGELTVRGIPGPVLVREHPPRRTFIAVFDGYPDGDRTLRLQRHGVDIGSHRSNVILPTGFGRHTHEGRWWARAPQRDESLPLLSEVVAAVERIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBP0</accession>
    <name>A0A231HBP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pat_1</name>
        <name evidence="5" type="ORF">B7C42_01257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46291">
        <property type="protein sequence ID" value="OXR46291"/>
        <property type="gene ID" value="B7C42_01257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="350" mass="36914" checksum="F419BEB80DD02096" modified="2017-10-25" version="1">MEFDLALSENPFPPLPSVLAVVNEAIRDANRYPEFLPRRLPAVIAAHLGVDADQVVVGAGATGVASQIMQAVAGPGRRMVLATPTFDGYPIMAAMAGLDVVAVPLDSNGRQRPAAMARAVDDRTALIAICRPHNPTGTVVPAAELKSFLFGVPRHVPVILDEAYVEFLAEAETVDPHELIARFPNLLVLRTFSKAYGLAGLRIGYAFGAPELVARVRRLQLPFGMPDYAVAAVRACYAASAELAERIADITAERESLRAALRHRGLAVPCSRGNFLYLPGPAVHATLAGAGIAAKGYPDGSARIAVGDPRADAAVLHAFDGRGEPVPRRRPPSGQAAGDRCTGYPVGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBP5</accession>
    <name>A0A231HBP5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase</fullName>
            <ecNumber evidence="2">1.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46310">
        <property type="protein sequence ID" value="OXR46310"/>
        <property type="gene ID" value="B7C42_01276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022480">
        <property type="entry name" value="F420_MSMEG2906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03856">
        <property type="entry name" value="F420_MSMEG_2906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="28936" checksum="71DC0B66CDE5DEF2" modified="2017-10-25" version="1">MTRPVRIGVQLQPQHAPDYGLIRDAVRRAEDAGVDIVFNWDHFYPLTGDPDGAHFECWTMLGAIAEQTERVELGALVTGGGYRNPDLLADMARTVDHISGGRLILGIGAGWFQKDYDQYGYEFGTPGTRLALLKEYLARIDARLPKLNPQPTRHIPILIGGGGERKTLRLVAEYADIWHSFADIEALERKSKILAEHCAEVGTDANRIERSVSWPGAEQAERLVAAGATLFTVGAGGPDYDLSVVEQAVAWRDNFNPESVAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBU7</accession>
    <name>A0A231HBU7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trans-aconitate 2-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.144</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tam_1</name>
        <name evidence="2" type="ORF">B7C42_01317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46351">
        <property type="protein sequence ID" value="OXR46351"/>
        <property type="gene ID" value="B7C42_01317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="24108" checksum="BADACDD2AF4B221F" modified="2017-10-25" version="1">MSANSDAVAAAYDEVAELYTGLFRDAMVNAPVDRAMLGLFAELVRAEDLGPVADLGCGPGRITGYLDALGLNIFGVDASAEMIRMAREVHPHLRFEHLPMEKLDVADGGFGAIVAWYSIIHMPAEHLPDLFAEFARALAADGYLMLAFQAADDGADRQPYDHKVAPVVRWSPEALAEMLRPHGLVPVTRMVRAPEPDERCPHGYLLVRRSATPAGSDAGRADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCN1</accession>
    <name>A0A231HCN1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46565">
        <property type="protein sequence ID" value="OXR46565"/>
        <property type="gene ID" value="B7C42_01536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="211" mass="22342" checksum="74672D8DA3745C55" modified="2017-10-25" version="1">MHITVFGAAGIAGSRIVREALSRGHEVTAVGRGERSDDLPAAASFRTADATDPAQVKDVTAGSDAVISATRPRPGREYELADVAAALLAGLRGTGIRLLVVGGAGDLLVPGAGTTVMQQPDFPPDWRPIALACHAQREVFHSATTDVDWTYLSPPALLEPGERRGTYRVGADELVTDSTGTSHISMEDLAVALLDEAEQQRHTRTRFTVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCT2</accession>
    <name>A0A231HCT2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46649">
        <property type="protein sequence ID" value="OXR46649"/>
        <property type="gene ID" value="B7C42_01623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11234" checksum="793AF3F658F2F48B" modified="2017-10-25" version="1">MIELQQAEPDPIETAIVQWCRKADLYRDGELVRQGVNLLGSNEPVAKAWAKLVAGHLATGDHTRDGLAKFLLSRDASGHVRAYSSAPIIAEGLLAMLTERNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDR8</accession>
    <name>A0A231HDR8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase B</fullName>
            <ecNumber evidence="5">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpiB</name>
        <name evidence="5" type="ORF">B7C42_00201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036499357.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47081">
        <property type="protein sequence ID" value="OXR47081"/>
        <property type="gene ID" value="B7C42_00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="4">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="16801" checksum="D7E2B862EFFD1A90" modified="2017-10-25" version="1">MRVYLGADHAGFELKNQVKDHLTQAGHDVVDCGAHEYDAVDDYPAFCIDAARRVVADPGSLGIVFGGSGNGEQIAANKVPGARCALAWSVETAKLAREHNNAQLMGIGGRMHSTEEAFAIIDAFLATPWSDEARHQRRIDIIAEYEKSGQPPAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDY5</accession>
    <name>A0A231HDY5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46917">
        <property type="protein sequence ID" value="OXR46917"/>
        <property type="gene ID" value="B7C42_00031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="355" mass="38968" checksum="C0289DF1511DF48D" modified="2017-10-25" version="1">MTRTRPAGQHEWEASFGRDELGRPVPPSRHLLILVDVVGTPDAAAARHLESALTDLERRYPHGRDGFLSTIGWGPTWWDRHTDHPGLIAVPARMSRYEDPILDTADAVFHIAGDHEDILADVRDTLFGESAGAQGEYLKVREVRTGFVGAGLPTAALPELGIPADAPLLFGFHSVLRGNQAPEPAITIASGPLAGGTTQHVSRIELDVQRWHALDRDRQAALLYGPTVTAAQAEKLNDDAPSDYDKYEQTVAEHGIVGHAQAAARARINNVPVINRRDFATLDDGRPGTHFVSLQRELRDFNNTRAIMNGADGPDYHKTVGARRRNGINAFFDVTHRATFGIPARELRAYPLHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE72</accession>
    <name>A0A231HE72_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sir</name>
        <name evidence="10" type="ORF">B7C42_00395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47273">
        <property type="protein sequence ID" value="OXR47273"/>
        <property type="gene ID" value="B7C42_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="199"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="375"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="449"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="592" mass="66842" checksum="EA687BF548B7E37B" modified="2017-10-25" version="1">MTSSTDAGPTPESVRAERERLARERRARPRPETSGPRERTGKPVRRKSEGQWALGYREPLNANEQSKKDDNPLNVRARIENIYAKGGFDSIDKSDLRGRFRWWGLYTQREQGYDGTWTGDENIDLLEAKYFMMRIRCDGGALNVEQVRTLGQISTEFGRDTADLSDRENLQYHWIEIENVPEIWRRIEAVGLQTTEACGDCPRVVLGSPLAGESLNEIIDGSWAVEEITRRYIGKKEYSNLPRKFKTAISGQQDVVHEINDVAFIGVEHPEHGPGFDLWVGGGLSTNPMLAQRVGAWVPLEEVPDVWEAVVSLFRDYGYRRLRTKARLKFLIKDWGVEKFREVLETKYLQRKLIDGPAPEKPTRPIDHVGVQKLRNGLNAIGFSPIAGRVSGTILTKVADAVERIGSDRIRFTPYQKLVVLDVPDDKVEELIAELEPLGLQARPSAWRRNLLACSGIEFCKLSFVETRKRSQVLAPELDQRLADINAQLDVPVTININGCPNSCGRSQIADIGFKGQLVDDGNGNQVEGYQVHLGGTLGLDAAFGRKLRQHKVTSEELGDYIERVVRNFVKNRNDGERFAQWAVRADEADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEJ8</accession>
    <name>A0A231HEJ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase LiaS</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">liaS_2</name>
        <name evidence="3" type="ORF">B7C42_00514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47391">
        <property type="protein sequence ID" value="OXR47391"/>
        <property type="gene ID" value="B7C42_00514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="220"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="450" mass="48522" checksum="6E875553F3C8C9A1" modified="2017-10-25" version="1">MDLTSADDRAEVSPHAPRRPGRARLALGRVARRLLDLVHDPAGTLRQRVEEMSYGYPVSVVVTADIAVVVSAVAAASLRSQYFSTGVPFLAVALLFACYPLLFFFDLPPKPAVFGLSALTAQALFLLQPVSPDCSPLVLTVMVGMIGAIAPKRVSLFWMLAAVAEMLIFYALGYGELVQVYVVAIVLGWMVGLMLQFQRQSLDQERENQAIRSAQAADDERRRIAREVHDVIAHSLSVTLLHLTAARHALETDRDVDEAIDALGDAERLGRQAMADIRHTVGLLDQRPSALTPEPGLEDIADLVSDFVGAGLPVTYHLSGDTAAVSASTGLALYRISQESLSNIAKHAPGAQASLDIAVVPGEVTVRVRNTLPQGPAPRTGRGMGISGMRQRTATLNGNLSAGRSGEYWQVRARIPLAPDEVCPVSGLDDPLTMVRDAITSLTRKRQEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEQ2</accession>
    <name>A0A231HEQ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ybeY</name>
        <name evidence="8" type="ORF">B7C42_00410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030512859.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47288">
        <property type="protein sequence ID" value="OXR47288"/>
        <property type="gene ID" value="B7C42_00410"/>
    </dbReference>
    <dbReference type="GeneID" id="66720866"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="20079" checksum="525E671B686362F9" modified="2017-10-25" version="1">MSIEIANESGIDVSEPDLVSVARFAIERMDVHPAAELSMVLVDLDTMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDGAEPGPSMLGDIVLCPEFAAAQAGKAGHSLDHELALLTVHGVLHLLGYDHAEPEEEKVMFGLQNRLLAEWYESLREAARRAELAERDRRLLGKTGFTAPGDPLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEZ5</accession>
    <name>A0A231HEZ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase DesK</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">desK_1</name>
        <name evidence="3" type="ORF">B7C42_00427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47305">
        <property type="protein sequence ID" value="OXR47305"/>
        <property type="gene ID" value="B7C42_00427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="212"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="43092" checksum="B629FFA961D850D7" modified="2017-10-25" version="1">MRVPPVDRPISGALDRIARRMDREPAPHTAIQHRRLFFGAVLALIWLLYLIAPIVSQWQDGHRMRAVAAAVCLAVFWVLTASCFGPFRQPDWDEGHAQAVLPVSYEWPRWLVVGALAALAATMTVLLGVTGLGTVIYVAAAAVFVLPTAKSGAVVAGTAALLIGLSLHYGSAPLYFAFIPVVMWTGREIGRRRGQLRELTRRQQGELAIVEERNRVARDVHDILGHSLTVITVKTELAQRLLDSDPSRARQEMADVERLAREALAGVRDTVGGLREVSLASELVNARTALRAAGIEAELPDPAEVPERYAVIFGWVLREAVTNVVRHSGARHCRVRVSESRIDIVDDGKGLSGSVFGSGLTGLRDRVRAEGGVFTVDTLPGGGTSIAVDFTTADEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF55</accession>
    <name>A0A231HF55_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47502">
        <property type="protein sequence ID" value="OXR47502"/>
        <property type="gene ID" value="B7C42_00627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012420941" evidence="1">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="13472" checksum="2934B1AF594105D4" modified="2017-10-25" version="1">MFVRAVPAVLVALLAAATFAVAGGVASAAPMPLPSIDSGGVTRLAIAPGQNSVTGQGSVGANKIANYSIGSARGQKLIVDITSNNGQARVTLAPLIGGPIAADVPHAEVVADGLDYQIYVSSADGSPSDFTLTVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFA8</accession>
    <name>A0A231HFA8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47365">
        <property type="protein sequence ID" value="OXR47365"/>
        <property type="gene ID" value="B7C42_00488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="117" mass="12582" checksum="2D443106E6C2949E" modified="2017-10-25" version="1">MLLQIVFIVLIAGALIALLMNFRGRGRFGGFQRGRLEAGTLRITGVSPRPAGQGEQFVTITGTLSGPSVPAETVYGRFAWDVNQWPFPGEDLPVAYPPGKPQHWQIGHPDPGPSAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFQ4</accession>
    <name>A0A231HFQ4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47813">
        <property type="protein sequence ID" value="OXR47813"/>
        <property type="gene ID" value="B7C42_00938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="130" mass="14584" checksum="C5791D61F4FB0D3A" modified="2017-10-25" version="1">MVHDPAARQIYPQEDLAPQSRSFVADLRAAVGRRSPGDSEASELVDELSQQSPEFRALWADQDVGVRRDERKRILHPTVGMLDLTCLSLFSEDSRQRLLWFTPRAGTDTAEKLALLTVVGTQAMHTEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFR2</accession>
    <name>A0A231HFR2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503311.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47679">
        <property type="protein sequence ID" value="OXR47679"/>
        <property type="gene ID" value="B7C42_00804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="14993" checksum="08EFF551521274FD" modified="2017-10-25" version="1">MQAFRQAVEARDSAAIEALLAENVVFTSPVAFKPYPGRAITAAILRGVLRVFEDFRYVREITDAGGHDSTLIFEATVDGKRVTGADFIHTDEAGRIDDLMVMVRPLSAANALAAAMGAQFERIQAEAAEQIERENAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFU4</accession>
    <name>A0A231HFU4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042840.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47841">
        <property type="protein sequence ID" value="OXR47841"/>
        <property type="gene ID" value="B7C42_00966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="15777" checksum="97CF8DAD8E750743" modified="2017-10-25" version="1">MTAGPSGDVEVGQDIGPVVLRADPVRLLRFGAATHNAHRIHYDPLYAEIEGLAGPVVMAQLHGALFHRAAAEFAGGPGGVVSVGWRNRAPAYVGSELVVTGVVREIADGFVTLELAEHTADGVLCAEGEAVVARHCEPGSLSRPNPLAPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFX6</accession>
    <name>A0A231HFX6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47782">
        <property type="protein sequence ID" value="OXR47782"/>
        <property type="gene ID" value="B7C42_00907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5413" checksum="02EDAB88B933BB4D" modified="2017-10-25" version="1">MSQPNHPHDDDTDEPRGGRPGPVDEGDNGGMATREVADDVGTEENAQEPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG13</accession>
    <name>A0A231HG13_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative D-xylose utilization operon transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gntR</name>
        <name evidence="5" type="ORF">B7C42_00772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47647">
        <property type="protein sequence ID" value="OXR47647"/>
        <property type="gene ID" value="B7C42_00772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="24559" checksum="43284FFA33C8B514" modified="2017-10-25" version="1">MSVIEFEPVNRQSTAEMIADRLRTAIMHGTVAPGTQLVEAELATQFDVSRGPVREAMQRLVSEGLLHSVRHRGIFVIELSLDDVVDIYRARTAIEGGALDLILDGRREIAYAALDTSVADMQACAARGDATGVTEADHAFHQALVTSADSPRLVRAARTLLIETRMCLGALQTTYTDLGEQVREHIDLREAIAAGPPDHVRELLAGHMRDAVERLRQQARDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG19</accession>
    <name>A0A231HG19_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="5">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dmlA</name>
        <name evidence="8" type="ORF">B7C42_00782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-malate + NAD(+) = CO2 + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47657">
        <property type="protein sequence ID" value="OXR47657"/>
        <property type="gene ID" value="B7C42_00782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="7">
        <location>
            <begin position="5"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="353" mass="37584" checksum="8D9364BBF5318FCD" modified="2017-10-25" version="1">MPMYRIATIPGDGIGVDVTAEAVKVLDAVLPGIAWTEFDWSCEQYLRTGAMMPDDGPRQLADFDAILLGAVGFPGVADHISLWGLLIPLRRAFGQYVNLRPVRLLPGTESALRGRGPDDLDILIVRENSEGEYSAIGGMHNPGRPDEFVVQESIFTRTGCERIIRYAFEQARRRDRRLCSATKSNGLIHSMPYWDSVFERIAAEYPDVETRQMHVDALAAEIVLHPDRLDVIVGSNLFGDILSDLAAAVTGGLGLAPSGNINPERDAPSMFEAVHGSAPDIAGMGIADPVAQILAGAMMLDHLGESAAAAAVDRAVCDVLAAGEVLTPDLGGTATTADLGTAIAERAAALVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG21</accession>
    <name>A0A231HG21_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NADH-quinone oxidoreductase chain 1</fullName>
            <ecNumber evidence="15">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">nqo1_1</name>
        <name evidence="15" type="ORF">B7C42_00947</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="15"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779665.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47822">
        <property type="protein sequence ID" value="OXR47822"/>
        <property type="gene ID" value="B7C42_00947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="Complex1_51K" evidence="12">
        <location>
            <begin position="64"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="13">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="NADH_4Fe-4S" evidence="14">
        <location>
            <begin position="332"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="42437" checksum="A0BF7FD17B5FD68C" modified="2017-10-25" version="1">MTTAIRSALHLAPALDIPARVAGDLPGRLVVPGVESPGWGLADERELGFFGAPVESADFLAELARSGLRGRGGAGFPAHRKWSAVAASSDSVVVANGHEGESASSKDAWLLTRRPYLVLDGLLTAAVVTGSAEAVVYASEPAVLASVRAAVAEVVAAGLVPPGVVLRVHEAPTGYVAGEESAVVASINGRPAKPVSKPPRPFEVGVRGLPTLVSNVETFAHAAWIRRYGAAEFAGAGTAASRGTALFTVTGRVAAPGVYEMPLGATVSDLVAAAGGGAVPMTGALLGGWFNGISLGDVGALSCCYDAMRAAGTGLGCGAITVLGPDDDPVALAAELAVWFQNESALQCGSCFTGTKAIARAYRQILRGEDAARHMTDLTRWGADLPGRGVCGLIDGAAALARSGVEELARRDARKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG25</accession>
    <name>A0A231HG25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_3</name>
        <name evidence="1" type="ORF">B7C42_00959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779656.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47834">
        <property type="protein sequence ID" value="OXR47834"/>
        <property type="gene ID" value="B7C42_00959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="25812" checksum="3A64F1679A2273D9" modified="2017-10-25" version="1">MSRTDLTGRTAIVTGSRRGIGAAIVRELLDHGATVVVCGRGEAGVADLVQTLDTTAPGRVRGCAADLTTAPGREHLLETAATVDILVNNAGGFTRVMDTLGSTLDEWNDQLAVNLTVPFLLCQAALPAMIEQGWGRIVNVGSIVASAPQLGNAIGYVAAKAGLVGFTSQLAAEVAHAGVTANVVNPGTIGTEHLRDYLAASDQMTEESLAGRIPVGRLGRPAEIAGVIPYLVSDAGAFITGAVLDINGGAIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGG5</accession>
    <name>A0A231HGG5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_00941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47816">
        <property type="protein sequence ID" value="OXR47816"/>
        <property type="gene ID" value="B7C42_00941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="211" mass="24059" checksum="8FDF8686950243EC" modified="2017-10-25" version="1">MSKSSRPTLTERRAEELRLAIANTARDMFVADGDTSATVERICETVGIAPRTFHRHFPVKEDVMGPLFRRSQAVIIDFLKNAPADADVAETLARAFTTEVYKRRTPESDRKFMTLMIHTPQYRLRWLEWGEQLCEPITEFLSARVELGDDPFLRRLPAELIVHTSRQAYIQWVDEEVGGDFSEVEALQLRGMKMLLVGLRAVMAQPSVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSJ1</accession>
    <name>A0A231GSJ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000718">
        <property type="protein sequence ID" value="OXR39535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39535">
        <property type="protein sequence ID" value="OXR39535"/>
        <property type="gene ID" value="B7C42_08397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="61" mass="6843" checksum="7A79BCBFBACC7D28" modified="2017-10-25" version="1">MIEITDAGRELVAEATRELNERVFALPGLAPDRLQQLLRLLAEFRQSAGDFDTGDTPTRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GST5</accession>
    <name>A0A231GST5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_08290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000108">
        <property type="protein sequence ID" value="OXR39642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39642">
        <property type="protein sequence ID" value="OXR39642"/>
        <property type="gene ID" value="B7C42_08290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR39642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="421" mass="46562" checksum="F6FCBA2F19DEB8E4" modified="2017-10-25" version="1">MSETLESVANDAADTKKLAEQLLAQAKEQGIDLVGPGGLLNQLTKTVLESALEAEMTEHVGYEKHDRAGRGTSNSRNGTRSKTVITEIGPVEIDVPRDTNSSFDPKIVRKRQRRLTGVDEIVLSLTAKGLTTGEVSAHFAEIYGASVSKDTVSAITDKVIAEMVDWCQRPLDRVYPVLFIDAIHVKIRDGKVANRPIYVVVGVTTGGERDILGLWAGDGGEGAKFWLQVLTEIKNRGVGDVCIAVCDGLKGLPEAINTVWSQTVVQTCVIHLLRNSFRYAGRQHWDRISKDLKPVYTAPTEAAAKERFNEFAAAWAGQYPAIVRLWENAWAEFVPFLAYDVEIRKVICSTNAIESLNARYRRAVRARGHFPTEQSALKCLYLVTRSLDPTGKGRARWVIRWKPALNAFAIAFEGRITLTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSV1</accession>
    <name>A0A231GSV1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000084">
        <property type="protein sequence ID" value="OXR39699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39699">
        <property type="protein sequence ID" value="OXR39699"/>
        <property type="gene ID" value="B7C42_08233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="21325" checksum="777ED1ECFD9A8369" modified="2017-10-25" version="1">MPHNTSTEATFAPGDEWRWLEPRSPVGGQEHPRLGMPSARMWMVVGATVTVAALLVLIGALTVADHGGHTPVPAFTAAPPTSSASAVGGACAGLTGTTVTDREGDPATLAGVVASFENAYYRLRDADAALRVVAPEAGLAAGALAAGIASIPAGSTYCVAITPIAAGSANVHVVEQHPDRTRTDYLQVINTRPTNSGLLITNIQKQAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSW2</accession>
    <name>A0A231GSW2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000082">
        <property type="protein sequence ID" value="OXR39706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063014053.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000082.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39706">
        <property type="protein sequence ID" value="OXR39706"/>
        <property type="gene ID" value="B7C42_08220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="128" mass="13536" checksum="707ACF70B0274CD7" modified="2017-10-25" version="1">MTNPNVMQGTSDDWNTAATKTALAAGELENQLRTLDATRHGLNTAVRSQHTGTAIDSTLADLHTSGTNLWRELDRIQTQIQKRGGQVDYDDLDAAQKVMAHDGSDGVLNATDGSGPASSGKISLTSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSX4</accession>
    <name>A0A231GSX4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000079">
        <property type="protein sequence ID" value="OXR39720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39720">
        <property type="protein sequence ID" value="OXR39720"/>
        <property type="gene ID" value="B7C42_08208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="690" mass="73913" checksum="285D959488405132" modified="2017-10-25" version="1">MRAEQRAALVEILTLERELEDLAADTIRAWLGTATQAALPVLTAASIGDIPPDPDGIARTAAAWDAEVNTGFLPRFGAIVDRLLGDDRDRLGEWRNRMVGAMRDRLSGIPARARKRVEAAIRDTVGQPLDAVRRAAARALSYADSWRGDATEIGRTAVGVFNAARIARAELETADTSRALDKVWLALHDGRTRHTHQLADRQRVPLGTDFVVGSATLPYPGWIGGPPEEVIGCRCVVAIVESALEIPAPARVASAADTGGTTVARSFEALLIPTGVVGRSQGWMLASNVQLVDTALPLAMKWQKKADPGHEGAYTVAVIQSIEVREGGVWGRGVTLDTPEAAEAAAEVEAMVSRPSIELVGRSEVLTDSAGNPVTPDTAEQMWMDGAAIVSRIDVAEIVAATLVSVPEFRDAHMILGDEVDNSQGLALVAAAKARTVDPDIYPAEFFDNPDLDEPTPIHVTREGRVVGHLACWKTMHTAYPDMQVTPYRSYSGYAEFHQSTAHLDNGERLRVGRLTVGGGHAVAGHGMRAAIEHYDDVGTCWSLVRAYEDAIGIAVSGVIEANADEKMVKLALGTPHSGHWERVGGHPELLIGHAVNSPGFPIPVAQRLRDRDGDLALVASFAPRPSRPPLPASLLEDIARRGAAAYAEQQAATARQATARELIANAVPRRRVLADAIKESHARHARKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT56</accession>
    <name>A0A231GT56_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000061">
        <property type="protein sequence ID" value="OXR39807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39807">
        <property type="protein sequence ID" value="OXR39807"/>
        <property type="gene ID" value="B7C42_08119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17812" checksum="9C632E22CBB09FF0" modified="2017-10-25" version="1">MGDDDPDDGGAYFTVVAAVLVMLLDFSRVIEVLDAWVGQGDHPFRSAATAVCSVVGQAEISAQHVDALLAAQPVGFIGDAGHRVHPRDPHRDIGRPELRGRGAEPLHEPALLNIPLTAVGDHQRHHPTDPADHGQRQLRDIHRGTAALWMKRGEQDPLRHHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTT7</accession>
    <name>A0A231GTT7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40029">
        <property type="protein sequence ID" value="OXR40029"/>
        <property type="gene ID" value="B7C42_07913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012466506" evidence="3">
        <location>
            <begin position="25"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="508" mass="50606" checksum="91B353F9A0D43F59" modified="2017-10-25" version="1">MRCNTDRNKGRRALASSRRRGAAAAVAGALIAGGGIQVATGDPVVPIGDRCPALFVFGVQGPDESATDTAPTVDTGALGQLFTPLAANAGDLVQRLYIPYGNADTGEPQPYDQATTSAAHRLESEATEVVHRCPTTKIAAAGWGQGAAAVTDFAHRVGDNTATVAADSIAGIALLANPARAGGDVLPGRPGQTTPAPAPGTTGSAVASIRLANTPDSGTGIDASLAGSAGFGTLAGRVADLCTPGDLACDAPVGSPLAQTVKNIAAQSNLGDPVAAISTIAQALAATTWKTAIGVVTDDIAGNSLDELSYQPTKPLGQRLAEASEPNTPMPGPDDALTALFRIGTIGLNTVVSMAQKVFTPATIAELATVGMANPAAALGVLGAKLAGAVADLIPPHTALGWVNQAFDAITSTVTDDNQLYQLATYTQYSDTAGHHAAYTGTPATPTGTPALAAVADWFTALAHDLAATHPTTAPPLPTTAGPDASTTPGAVPERTGTATPPPAVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTY8</accession>
    <name>A0A231GTY8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40062">
        <property type="protein sequence ID" value="OXR40062"/>
        <property type="gene ID" value="B7C42_07866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="22818" checksum="7FD6DAC1102C5E88" modified="2017-10-25" version="1">MDFGQPNQKPTAICLVRAEVSGSHATRHAMEVQRHAERLGYLHLYTVRPPADATDPVGYALGLAASLNVDAVVVYDLETVGNTPSRVCEMFDLETVCPPATWAANLPGFSDPEHSHPQQPLTADTAQQIMQQHKNCRAVECPRKASAYSCLVREGKIVPPVDTPRERAAARAPRFRPRRTNDAPLPDGVSLETLLDVLGGLADYASVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU22</accession>
    <name>A0A231GU22_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator McbR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mcbR</name>
        <name evidence="5" type="ORF">B7C42_07784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40120">
        <property type="protein sequence ID" value="OXR40120"/>
        <property type="gene ID" value="B7C42_07784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="24181" checksum="61F5DA08A4A6DC43" modified="2017-10-25" version="1">MVAELERLIVTGELLPGQPIRQVLMAERLGVSRLPIREALRHLTAEGLVAHEPNVGYTVARLQQSDFDQIYLMRAALEREVLLSLPAFSADALAEATRAAHQVVEAAEQGDVLAMRMHNHAFHFVIFERSPLNLIVAEIRRLWTLAMPYHAAYLYDPAARARVVAEHDQMIEALTRHDNERLVELMNEHRRGGETSTGMMLRATRTGAPPVPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU90</accession>
    <name>A0A231GU90_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776359.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40190">
        <property type="protein sequence ID" value="OXR40190"/>
        <property type="gene ID" value="B7C42_07704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9888" checksum="1CD7A71BD28654E6" modified="2017-10-25" version="1">MSSYFCMDGALEGVAEVEYKAAHIYRYGPDRQYSSPIPAYVFVRLGKGFPEVRLRLSIEDVRALAEQLPQILMLHDAAERLAVEKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUA4</accession>
    <name>A0A231GUA4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">thrB_2</name>
        <name evidence="11" type="synonym">thrB</name>
        <name evidence="13" type="ORF">B7C42_07722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776820.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40207">
        <property type="protein sequence ID" value="OXR40207"/>
        <property type="gene ID" value="B7C42_07722"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR40207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="33218" checksum="4F22B4FC293E16A1" modified="2017-10-25" version="1">MTRTLPPGITVTAKVPASSANLGPGFDSLGIALGLYDEIVVRTTDSGLTIRVEGEGADDVPWGPSHLVVRAIERGLEAAGVWADGLDVVCRNVIPHSRGLGSSASAAVGGLAAARGLAAKFDPALTGSDAELVQLASEFEGHPDNAAASVLGGIVVSWTESDRAGELDASSSVEHHQRVYRAVRLEPHPRLRATVLIPQERSSTAHTRGLLPETVPHGDAAFNVSRAALSVVALTERPDLLLPATQDRLHQGYRATALPLTTAWITRLRTAGLAAMVSGAGPTILALSTGEFPDDLRKLAEEDGLRVVEPDISAGVSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUA6</accession>
    <name>A0A231GUA6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40196">
        <property type="protein sequence ID" value="OXR40196"/>
        <property type="gene ID" value="B7C42_07710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="57" mass="6257" checksum="4642EE44AAD89A92" modified="2017-10-25" version="1">MSKRTSEYDDVIDLHARRRCQLEARGLDPIGIAVNILAETGTVFGYGYDPDGGDWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUX9</accession>
    <name>A0A231GUX9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40355">
        <property type="protein sequence ID" value="OXR40355"/>
        <property type="gene ID" value="B7C42_07521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="118"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="345" mass="37065" checksum="74B3F14564805440" modified="2017-10-25" version="1">MSYRKPLIVLIVFLVVSIGLTWTMYVTLARSVSGRTETYSAIFTDVSGLHAGDDVRMAGVRVGRVQAVDLDGIRAEVTFEVQQGQRLYGNTAASVTYQNLIGQRYLGLSLRDFGEPGVLPPGSRIPVEHTEPSFDISKLLNGFEPLFSMLDPQQIDNISAAVVRALQGDDGAITTLIAETASLAQAFAGPDQILGQVIDNLSGVVGDLSRQSGNLRTILQQTHRIFDGLAQQRDQLFGQIDAISGTSSRAAAVVRGASPALNHIVDRDPGFAQHFIDNKDKFAYLGFNLPLLLKGLARITDNGAYLDAYVCDVRVGMIPGIDPLIATILGQGTPSGKVEHSGICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVB2</accession>
    <name>A0A231GVB2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
            <shortName evidence="3">GlcNAc-Ins deacetylase</shortName>
            <ecNumber evidence="3">3.5.1.103</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">mshB</name>
        <name evidence="4" type="ORF">B7C42_07379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate</text>
            <dbReference type="Rhea" id="RHEA:26180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:52442"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="EC" id="3.5.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MshB deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.103" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40570">
        <property type="protein sequence ID" value="OXR40570"/>
        <property type="gene ID" value="B7C42_07379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035595">
        <property type="term" value="F:N-acetylglucosaminylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01696">
        <property type="entry name" value="MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017810">
        <property type="entry name" value="Mycothiol_biosynthesis_MshB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03445">
        <property type="entry name" value="mycothiol_MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="31712" checksum="7E05BA3F1676F74D" modified="2017-10-25" version="1">MTGTGGLVLVHAHPDDESITTGGTIAHYRARGVPVTVVTCTLGEEGEVIGEQWQQLTSAHADQLGGFRIHELTDALAALGVDAPHFLGGAGRWRDSGMSGTTADPEPMVPTHPRAFVDSGPAAVAELSEVLLRLRPRVVVGYDPRGGYGHPDHVRAHRVTMDAVAAAAEKGWDTPKVYWTVTDADVLRRHTEALARRTVDRLPGALPSGWRLPAIGELACVASETVTTTIDVSDVLAAKRAALRAHATQVTVAPSGREFALSNNIAQPVLPEEHYVLVRGRIGPVGPDGHEDDLFAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVF2</accession>
    <name>A0A231GVF2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ORF">B7C42_07377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780534.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40568">
        <property type="protein sequence ID" value="OXR40568"/>
        <property type="gene ID" value="B7C42_07377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="4"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="633" mass="68409" checksum="31D341C2112ABD12" modified="2017-10-25" version="1">MSSVEFRNVAIVAHVDHGKTTLVDAMLRQSGAFAERAEPVDRVMDSGDLEREKGITILAKNTAVHRHHGDGSVTVINVIDTPGHADFGGEVERGLSMVDGVVLLVDASEGPLPQTRFVLRKALAASLPVILVVNKTDRPDARIEEVVEESHDLLLDLASDLDDEASEAAELALDLPVLYASGREGKASTQRPENGSAPDAENLDELFEVLLKYVPAPKGDPSAPLQAHVTNLDASPFLGRIGLVRIHNGTLRKGQNVAWMHGDGVKTVKITELLQTIGVERKPGEEAVAGDIVAVAGIPEIMIGDTLADVENPVALPRITVDEPAISVTIGTNTSPLVGRVQGHKLTARMVKSRLDQELVGNVSLRVLDIGRPDAWEVQGRGELALAILVEQMRREGFELTVGKPQVVTKQVDGKVHEPFEELTIDCPDEYLGAVTQLLAARKGKMVQMSNHSAGWVRMEFIVPSRGLIGFRTDFLTETRGTGIANAVFDGYAPWAGEIRARHTGSLVSDRAGTVTPFAMIQLADRGQFFVEPGADTYEGHVVGINPRAEDLDINVTREKKLTNMRSATGDVLETLAKPLQLDLEGAMEFCAADECVEVTPEIVRVRKVILGATERGREASRRKARDRAAQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVF7</accession>
    <name>A0A231GVF7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40609">
        <property type="protein sequence ID" value="OXR40609"/>
        <property type="gene ID" value="B7C42_07294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="35056" checksum="989D387A33BBC145" modified="2017-10-25" version="1">MLLIALTVAATGFLIHETRRDTRMAVILRTENIGDGIGVGTPVRYDGVDVGSVARVDADGINTKKVTLLLDRAHLIGLTDNLFVNYSPSNLFGISEVALKEAAGGVPLRDGIVVDLTGPRSNRQQDATMGVLIRTVAEATGDLLTPRLTEVLMRLSETSRQFTPLMETIVSMSRMVAETQKMPPSYLLDQYGSMLVGAGAMFDGTVGLISRLTRIEILNSQRGLFDATVNTVGEKFFPALANTIFTARNYLSDYTAMLVPILSAASSMVPTPEVSSAQLSEILARLGNSFTQTPDGPVLNLKVIVDSFPGLATPLLASLPKSDAGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVZ1</accession>
    <name>A0A231GVZ1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40784">
        <property type="protein sequence ID" value="OXR40784"/>
        <property type="gene ID" value="B7C42_07208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="177" mass="19730" checksum="C61C9A102CD8DA50" modified="2017-10-25" version="1">MPRTVYYTATTLDGFIATPDHRLDWLLTRQVDNDGPMGYDTFIADIGAIAMGANTYRWILDNHPDMEWPYSMPAWVFTHRDFDPRTDGADVRYTQQPITVVHKEMTEAAAGKSLWIVGGGELAGQFADHGLLDEVCVSIAPITLGAGQPLLPRRVEMKLTELAQNGEFACARYAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW43</accession>
    <name>A0A231GW43_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ftsX</name>
        <name evidence="14" type="ORF">B7C42_07082</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780104.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40798">
        <property type="protein sequence ID" value="OXR40798"/>
        <property type="gene ID" value="B7C42_07082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="204"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR40798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="33067" checksum="29EBDC54A5C2B368" modified="2017-10-25" version="1">MRASFLFGEVFNGLRRNVTMTIAMILTTAVSLTMLGGGMLAVRMADKTEQYFLDRLEVRLYLTEDVSANDPDCSQDPCKALMSSLKSEPGVESVQYLNREEAVREAKEKTFKDQPELAKYVSESPLPASLRVKMTDAAQYPRIFKDFQGKPGVGFVRNDKDIVDRLVSLFDGLRNAAFGLAVLQALAALLLIANMVQIAAFTRREEVGIMRLVGATRWYTQLPFLLEAVVAALAGSVLAVIGLMIARPLVIDRALGDLFASKVFPRITGDDIAVVALTVVPVGIVFAALTAYGTLRYYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWB4</accession>
    <name>A0A231GWB4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_15</name>
        <name evidence="4" type="ORF">B7C42_07052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40917">
        <property type="protein sequence ID" value="OXR40917"/>
        <property type="gene ID" value="B7C42_07052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="46545" checksum="2A8725777EDF4F96" modified="2017-10-25" version="1">MTATAQPAHVILNVNVLDVGIAPGAWTLDDVPAGAFVDAGHFVQAARTAERGTLDALFLADGPALREDPRHKPGRALEPGVILSAVAAETEYLGLIGTLSTTFNDPVELAERLLSLDHASGGRLGWNVVTTYSPAAAGNFGLTEMPDRDARYRRAEEFVEVVRALWDSALDGGVVHHHGEHFDVEWGLRTPPSAQGYPLFVQAGGSPAGRILAGRSAHAVFSAELTAAAAIRHYRHVKSVAREAGRDPGEVKILPGLTTIIGSTEAEALQRFQTLFRSVDEGPERIRLEATLGVPLDSLDFDRPLPEAVLAGPPDPSTFSASLGFRESIVELARERDLTLRELIRELHGGAGHRAVIGTPEDVADTIEDWFRRGAADGFNLMPDAFPSGLTTFVDEVVPILRRRGLFRHEYTDSTLRERFGLPVPAPAAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWE3</accession>
    <name>A0A231GWE3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane protein YbjJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybjJ_2</name>
        <name evidence="7" type="ORF">B7C42_06905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042790.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40939">
        <property type="protein sequence ID" value="OXR40939"/>
        <property type="gene ID" value="B7C42_06905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="218"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="41944" checksum="ACFFFBFCDEA45A76" modified="2017-10-25" version="1">MFDRGYIPVSTTLRAARTANSVAFALQGFFLAVVLTELPQQRDRLGLTDTVILVAVVLISGLAAGGSLLAERVALRWSSRVALRAGLALIAVSGLAIAVAPNLVVDLIALGCYGIAVGMVDAGTNMQAVFIQHGYGRFVLSSFYAAWSAGSILGALFVSGCEKVGITLPYAVTVAAAVVAVASLVFGPRLLGAGQAEAQPTDSGRTPEAVAPVALRAYLALGIAMALVFAIDLAVGNWSALYLTDDLLSSSATAALALAAYQGASLLTRLSGDWWVRRYGARAVVRTAAGIGVLGLALVVAAPGPATALAGFLIAGLGLPVIAPLCFSEAGRLTEGRGLDAVIARLNLFNYAGTLIGGGVVGAVAAASSLRIGFAIPLLFALVLIATARFFRPRPAPGDLSATHAGHVVLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF1</accession>
    <name>A0A231GWF1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_35</name>
        <name evidence="1" type="ORF">B7C42_07030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40895">
        <property type="protein sequence ID" value="OXR40895"/>
        <property type="gene ID" value="B7C42_07030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="24551" checksum="CB02830F12E0C8E1" modified="2017-10-25" version="1">MPVAIVTGASAGIGRAIAGRLGSEGMAVVVNYLGNRTAAEELVTTIEACGGRAVAARADVSDPAQLRGLFDLAEDEFGGVDILVNNAGTARFAALAQATDEDFDLTFSLNVKATFVALREAANRLRDHGRIVVISSGVTVTHRPGSAVYAASKAAAEELVRVLAKELGPRGITVNSVLPGATRTEALAGARSTAALEEVAAATPLGRIGEPGDIADIVAFLVSGNARWITGQSVRAGGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWI6</accession>
    <name>A0A231GWI6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="10">PEPC</shortName>
            <shortName evidence="10">PEPCase</shortName>
            <ecNumber evidence="5 10">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">ppc</name>
        <name evidence="13" type="ORF">B7C42_06956</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 10"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40990">
        <property type="protein sequence ID" value="OXR40990"/>
        <property type="gene ID" value="B7C42_06956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="8 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR40990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="934" mass="103100" checksum="EA1E4F7A54813B4B" modified="2017-10-25" version="1">MVDTGGMREDQIESATAPLRDDIRFLGAILGETIRDHEGPEVFDLVERVRVEAFRVRRSEVERSAVAEMLRDTELPVAIPLIRAFSHFLLLANLAEDLQRDRRRAVHVAAGEPPQESSLAATYRALDHARVDGALAAEVLEDALVSPVITAHPTETRRRTVFDVQARITELMRRRARYREDEPEYATIDHDLRRQILTLWRTALIRLARLRISDEIEVGLRYYDLTLLEVIPRINAEVREALRARWPGHDLLARPILRPGSWIGGDRDGNPNVTGEVVERATRRAATVIFGHYLKELVALEKSLSQSIRLVAITPELSRLADAAGDDSPQRADEPYRRAIRGIRLRLAATAQRALGSAAEFPSVYELSGEQLARVSPYEGPDQLLDDLNTVDASMRESGDGLLADDRLAALRGAVETFGFHLQGLDMRQNSEVHEQVVAELLAWSGVHADYRSLPEPERVELLADELSTRRPLLGPHARLSELATKELGVVRAARAAIDALGPDTVPNYIISMCTSVSDMLEAALLLKEAGILDPGDDQTPPHSPVGVVPLFETIDDLRGGAATLAAALEVPAYRRLVAARAMAQEVMLGYSDSNKDGGYLAANWALYRAELDLVETARKTGIRLRLFHGRGGTVGRGGGRSYDAILAQPAGAVRGSLRLTEQGEVISTKYAESGSAHRNLESLVAGTLESSLLDVEGLGSGAEAAYEVFEELAEAAREAYARLVHRTPGFVDYFRASTPIAEVADLNLGSRPASRKPTSSVSDLRAIPWVMAWSQSRVMLPGWYGTGSAIQEWAGTDSERWQTLRDLYRRWPFFRTVMSNLAQVMAKADMDIAASYAELVEDATLRTTIFGMIRDEFDRTVQVHAAITGSDQLLSDNPALAESIRNRFPYLEPLNQMQVDLLRRRRAGDESELVERGILLTMNGLATALRNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWM8</accession>
    <name>A0A231GWM8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal RNA small subunit methyltransferase C</fullName>
            <ecNumber evidence="3">2.1.1.172</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsmC</name>
        <name evidence="3" type="ORF">B7C42_06954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.172" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40988">
        <property type="protein sequence ID" value="OXR40988"/>
        <property type="gene ID" value="B7C42_06954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052914">
        <property type="term" value="F:16S rRNA (guanine(1207)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="524" mass="55871" checksum="2EBCE8488F55D6F2" modified="2017-10-25" version="1">MPADRTTASLLTALAPALRAALTRVRYDADTVLDAIGADAHAALGRSEPVPVRRAAREAGELGTLIRLLLLGDALPEREVAAAFAPLDIDRAVAAGLLERDGDSIRAALDLRPLDLGSGTRWVLSDLDDSMRRRTLSADHVLGVGQASLSLLRATPTDPVGSVLDLGTGCGVQAVHAAGYAKTVTGTDVSSRALWLAEATAALNGLDIEFVEGSWFEPVAGRRFDQVVANPPFVVGPARIEHTYRDSGLALDGASELVVSQAPGLLNPGGTAAMLASWVHAGDADWRTRVASWLPDRGVDAWIVQRDVADPALYVGTWLRDAGLDPRDPEAQRRAEQWLAAFDTAQVEGIGFGFVYLRAIDGPTEVLAEDLTHGFDDPLGAEAPSYFRRSAWLRTVLADNEVAWRARFTVDAATALERVLLPGAEGWQERVVRLHRGDGPRWQHEIDDTLAALLAGMRPDGLPLEELVELLAIGHTGTTATPQFRAEALSAVTGLVRHGLITPDELDATPADAARTPTSSEFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWQ2</accession>
    <name>A0A231GWQ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-CoA:(R)-benzylsuccinate CoA-transferase subunit BbsF</fullName>
            <ecNumber evidence="1">2.8.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bbsF_1</name>
        <name evidence="1" type="ORF">B7C42_07066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.15" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783825.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40931">
        <property type="protein sequence ID" value="OXR40931"/>
        <property type="gene ID" value="B7C42_07066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033877">
        <property type="term" value="F:succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="780" mass="84259" checksum="EC351EE49217FDF5" modified="2017-10-25" version="1">MAEATVRVVELSSPFTRFAGRILVGLGYEVVLVEPPAGDPARRELDGYAFAHWHGGKRSVVLDPDADRDGLANLLSGADVLLDGTDTRSEPVVGTHDSLVHVRVTPFGVSGPHSAWAATDLTIAAMGGMMAQVGTPDGPPLRLPERQAEQLAGVNAAIGALLGLRARRFGPAPFVDISAQECVAASLEAGTLTYLHEDRVPDRPGRAHPLVPHGLFTAADGFLGGGLGGSPRMWDQTLRWLVEEGAQEDLDEPRWNDPVERKTHRDHIFAVLQRFLAKWPKEEFAVRAQERKLPWAAVDGPAELLANPQLNDRDFFLDVVSGDESTRDLGFGFAFPEGRRVRELLVPELGADQALTVEKRAGSARWPTNEQPIGTGSLDGIRVLDLTWVLAGPYCTRILADHGAEVIKVESMGRPDPTRFSPAMHLSRGPHDDPDTSGYFNDVNRNKRSITLDTRTPEGLEVLADLIAASDVVIENFSSSVMTKMGLGYQRLRELRSDIVYVSMSGMGHTGPRSNWVSYADIVSASTGLTALTGRQADDVVGVIYGHGDIVAGLQAATATLAALEHRDRTGHGQHVDLSQLEAMAAHMGTSVIQSTGTGHAPEPTGNTDTAYAPHGVYRCLGTDRWVAIAVRDDSDWCSLCELIEHPEWATGAQFRTVERRRAHDQEITAAITAWTRTLPAQSVTEALQNAGVPAGVVQNGRDLVESDAHLRARGFYVRCTHPRVGAFLHEGAPVRLDRAGGEIRSPAPLLGADTDSILRDVLLYAPDRIARLRAASVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWQ4</accession>
    <name>A0A231GWQ4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="10" type="ORF">B7C42_06978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779451.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41012">
        <property type="protein sequence ID" value="OXR41012"/>
        <property type="gene ID" value="B7C42_06978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="17724" checksum="AD17F3DEC5948844" modified="2017-10-25" version="1">MHCPYCRHPDSRVVDSREAEEGSAIRRRRACPQCGRRFTTVETAILSVVKRSGVTEPFSREKVIRGVRRACQGREVDDDALNLLAQQVEDAVRAKGSPEVPSHEVGLAILGPLRDLDEVAYLRFASVYRSFSSADDFEREIDDLRRHRAERSVAAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWT3</accession>
    <name>A0A231GWT3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent stearoyl-CoA 9-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">desA3_5</name>
        <name evidence="3" type="ORF">B7C42_06812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41042">
        <property type="protein sequence ID" value="OXR41042"/>
        <property type="gene ID" value="B7C42_06812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="418" mass="47350" checksum="538FE539129A4213" modified="2017-10-25" version="1">MAISDVKEYAHLTPEDVEAIGAELDAIRREIEASRGETDARYIRNVIRLQRALEIGGRATLFASFLPPAWLAGTAMLSAAKIIENMEIGHNVMHGQWDWMNDPEIHSSNWEWDNAGPSEHWKITHNYLHHKYTNVLGMDDDIGYGLLRVTRDQRWSPFYLGQPVYNLLLQMFFEYGVAIQHLELGKVAKKKWAPDSPERRQFEQDRKLVLKKVGKQAAKDYLIFPLLTGPAFLSTLTANITANIVRNVWTNAVIFCGHFPDGAEKFTKGDVLNETQGEWYLRQMLGSANITGGAVMHFMTGNLSHQIEHHLFPDLPSNRLRAIAVRVRELCDKYDLPYTSGSLPVQYAKSWRTIIKLSVPNKYLRRGTDDAPETKSERAFGGIGTVDPVTGRRRGLRTALKEGKRRVAQRRQTVGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX16</accession>
    <name>A0A231GX16_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tcrY_4</name>
        <name evidence="11" type="ORF">B7C42_06753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41157">
        <property type="protein sequence ID" value="OXR41157"/>
        <property type="gene ID" value="B7C42_06753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="211"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="288"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR41157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="518" mass="54971" checksum="1E16C47A6C9BB922" modified="2017-10-25" version="1">MRRTRRWWSARGWSLRARLLVGQLLLLVVVVVGIGAATEFALQQFLVHQLDTELVDVQKRSLGEAGGGPSLGPPPGAQDHDNRPPPPNHGGPGPDFLDRRGIQADTVGASIDGTEITAAKIDADGTQTRLSAAAQRQLAEVSSDGTPVTVDLDGQGSYRVVANSTWSGATVVTGMPLTAVHATLMRVLLILVVVTAVVFVIAITVGIWVIRRALAPLDRVAATASRVADLQLDRGEVELPVRVPADDADPRTEVGQLGSAVNRMLDHIDSALSARHASETRVRQFLADASHELRTPLAAIRGYAELAQRKRAEVPGDVANAMSRVDSESRRMTALVEDMLLLARLDSGRGLEHEPVDVTRLTVDAVSDAHIAGPDHRWDLDLPDEPVVVIGDAARLHQVLANLLTNARVHTGPGTTVTVSLEREAGGAVWRVADNGPGIPAALQPEVFERFARGDSSRSRRAGSSGLGLAIVAAVVKSHGGTISLDSAPGHTVFTVRLPDQTSQRAHSEAPGGHHLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXD1</accession>
    <name>A0A231GXD1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DegU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degU_5</name>
        <name evidence="5" type="ORF">B7C42_06691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41293">
        <property type="protein sequence ID" value="OXR41293"/>
        <property type="gene ID" value="B7C42_06691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="249"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="34585" checksum="22DCD20A71650F00" modified="2017-10-25" version="1">MSGSGPQEAAERDHTGRDAQDVEPTADALIAAMRTASGPRLTELGSQLAERLEREQALRDNEIDELRRAAQRLDRAVADLTDASSGAVLLRRACAALADICSAERVLASSIEADRAVPVATYESGDAAAIPADYPLLPGSAESRVVTGGGAPLTGRPVAALRHLFPQDCTIMVVTVADTPALIVHVAQIFDAAQHDSATLVLEVLGGCLRRLGLAARRARQLELLRSSGVAREGHTDVPAAETAQEPTPPAPPWMEPLTERESEVLRLILTGSSNTAIATELVITVDTVKSHVKRILRKLGATNRSELIARHSAGALTNRSIAPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXT1</accession>
    <name>A0A231GXT1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780444.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41375">
        <property type="protein sequence ID" value="OXR41375"/>
        <property type="gene ID" value="B7C42_06518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="16035" checksum="6619446446028B16" modified="2017-10-25" version="1">MPLWHVYHPANTYSDQDKADFARDVTTLYTGFGLPAFYVVVLFEEVEQTSFFVGGKPSADTVRVVVEHLARHLDDPDMRKRSTQRLNAVMEPYTGARGLHWEFHTYESPRDLWMIAGLFPPEAGSEAEKAWARAGEPSPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYH9</accession>
    <name>A0A231GYH9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41667">
        <property type="protein sequence ID" value="OXR41667"/>
        <property type="gene ID" value="B7C42_06308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13092" checksum="B6F7E4F99A1BCDA5" modified="2017-10-25" version="1">MTTAGLILACLAAAIHIYIFYLESVAWTRPKTRAIFGVSSAAEAETTRPLAFNQGFYNLFLAICVIAGTVFFAVGETTVGATLVFTGAGSMTAAGLVLLLSSPDKASAALKQLVPPLLGVIVLAIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYP7</accession>
    <name>A0A231GYP7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purN</name>
        <name evidence="5" type="ORF">B7C42_06085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41743">
        <property type="protein sequence ID" value="OXR41743"/>
        <property type="gene ID" value="B7C42_06085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="17836" checksum="F9AD99E2E3B37B46" modified="2017-10-25" version="1">MGVDRTCAATEHAVRAGIPDFRVAPADHPDRSAWDIALTDAVAAYAPDLVVSAGFMRLFGPKFLERFEGRIINTHPALLPAFPGAHGVRDALAYGVRVTGSTVHLVDAGVDTGPILAQEPVAVLPDDDEASLHERIKVVERRLLADTVAAVATRGIVCDGRKAVIPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYS3</accession>
    <name>A0A231GYS3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41757">
        <property type="protein sequence ID" value="OXR41757"/>
        <property type="gene ID" value="B7C42_06099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="28068" checksum="0D79B1810E778DEC" modified="2017-10-25" version="1">MDSVPFDTAAPPPHTGAPSTAERYPPAPQPDSAQIGPLGANSPGSHAQPPLPYQNPPMHFQNSTAPMPPHPELDSRTASTKIVVAGGFGAGKTTFVGAVSEIVPLRTEAMVTGVSDGIDDLSATPGKETTTVAMDFGRIILPGNLTLYLFGTPGQRRFWFMWDDLIRGAIGAVVLVDTRRIEDSFAAVDFFEARGLPFLVAVNRFPSAPRFPVAELREALSIREGVPVVDIDARDAGEVRRALAAVTEYAIQRLTATHATVGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYZ6</accession>
    <name>A0A231GYZ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_27</name>
        <name evidence="1" type="ORF">B7C42_06178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41836">
        <property type="protein sequence ID" value="OXR41836"/>
        <property type="gene ID" value="B7C42_06178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="33014" checksum="262805B9196A9878" modified="2017-10-25" version="1">MTWHSGCRAEGKTILVTGASAGIGYFVAERLAAAGATVALGCRDTAKADLAMRAIRARVPAARTMSVRVDLADPSSLPATVDALGVERLDGVVLNAGILLPDPERQVTARGHESMFATNHLGHFALVAHLAPMLTAAPHGRVITVGSFAARSERLDLTDLQSERDYRSKRTYGRSKLAQMLFGFELDRRLRASGADTASIVAHPGGALDSLTPSRPPLFVHTPAQRLRGLPAGVVLHGKHAGADSIVRATLDTEITGGELWGPRVLGLRGRPHRETPHAHMTDPDVATELWAVSAELTGVDPLKCPATPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZL9</accession>
    <name>A0A231GZL9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cycA</name>
        <name evidence="10" type="ORF">B7C42_06033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42049">
        <property type="protein sequence ID" value="OXR42049"/>
        <property type="gene ID" value="B7C42_06033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="32"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="472" mass="50105" checksum="E1ACF92628BB13AA" modified="2017-10-25" version="1">MTTDRKPEGTGAPALASAGEEGYQRGLNPRTIQMIAIGGAIGTGLFYGSGGAIEQAGPALILCYLAAGLAIFVIMRALGELLTYRPVSGSFGEYAHEFLGRFAGFVTGWTYWAVWVATCMAEITVAGKYIKYWFAIPEWVTALVVLGVLFAANLISVKLFGEGEFWFSTIKVTAIVAMIAIGIGVLIFGFGHAPDPTVTNLWADGGVFPNGFGQALLALQIVLFAYVGVELVGVTAGEAADPRRTLRRAINSLPLRIGLFYVGALIVIMSVSSWRVFHSGRSPFVEVFEQIGIPGAAGIINFVLLTAALSSCNSGIYSTGRMVRSLSLRGEAPVALGGLSNRRVPFAGILLSAAMMVIGVIVNLVSPDKAFNYITSVSTIGIIFVWGMILVCHLIYRVRVRRGELPASDYRLPGAPVSSVLALAFLGLVVVLLFWTDSGRTALVVGLAWAVLVCAGYPVVNRLARRRAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZN5</accession>
    <name>A0A231GZN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42074">
        <property type="protein sequence ID" value="OXR42074"/>
        <property type="gene ID" value="B7C42_05673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="28434" checksum="5C199D611BC6CB52" modified="2017-10-25" version="1">MSDSSAPASTHPSWERDGICLMENAISGGDLDRLQRWVSELEAEPGTTDGLLQYDEKTADGSMRRCRTENFVPFHEGLRTLLTAGDIPRIASELLGEQAVLYKEKLNYKAPQGAGFRPHQDAVAYPNVQQTLACMVAVDDASVTNGCLEIVRGAHHEQLPTDETGCIDPAIAATMSWEPLPVSAGSLLWFHCWVPHRSGANTTTATRRAIYLTYNRISDGDLRADYYSGKLAELRTQPERLSLIAHFAGQSSPSTEIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZT6</accession>
    <name>A0A231GZT6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777762.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42062">
        <property type="protein sequence ID" value="OXR42062"/>
        <property type="gene ID" value="B7C42_05661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="24286" checksum="651363F671E2BBED" modified="2017-10-25" version="1">MTSLHDRHLVHGVDHAAFPTFDPAATVRFYRDVLGFPVVHSVCAAGWGPNDHPDFVHFFFDIGDGDRIAFFYYFGTEPVNTTGRGDAYSGFGPEVPQFFLQSRHLAIHVESEEALLEYRRRLDASQWPVEMQVMHETIESIYTHDPNGYMFEITRALRPVTPQEDLDANLSVDALVDVVSQPEPTLGKLLARKAELIVERAAQWDPQRDRTGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0A1</accession>
    <name>A0A231H0A1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42304">
        <property type="protein sequence ID" value="OXR42304"/>
        <property type="gene ID" value="B7C42_05503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="56" mass="6518" checksum="DE4752CBE7AABDB9" modified="2017-10-25" version="1">MNVFGNQSGDLMAEHEKPAEDAPEEEWLRWHLRDRPSRSEQHYDTIARILDGRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B8</accession>
    <name>A0A231H0B8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxybenzoate 6-hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhbM</name>
        <name evidence="2" type="ORF">B7C42_05487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.24" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42288">
        <property type="protein sequence ID" value="OXR42288"/>
        <property type="gene ID" value="B7C42_05487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018669">
        <property type="term" value="F:3-hydroxybenzoate 6-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="42654" checksum="622C93D6360E8B3D" modified="2017-10-25" version="1">MRNTTVLISGASIAGPALAYWLQRYGFAVTVVERAPELRAGGQAVDFKGATHRTVLERMGVWEEIHRRQTGKTDMVLTDAEGAELAVMSGDFTGGDVEILRGDLAEIFYERTVHSCEYVFGDSVAALRETAAGVEVEFENAPARTFDLVVGCDGIHSRVRALAFGPEADYVKHLGYYYCTAGAAGWGHDPNGPRQRNRSEAYNEPGRLAVRGGNKAAHMYMFAAEPLTYDRHDEAAQRRVLAEAFAGARGPVPAMMAELSGLDSFYLDSLGQVGMKKGYTTGRVALVGDSAYGNTLGGFGTGLAVVGAYVLAGELALADGDHTAAFARYDELMKRYAKIAGKSNAGRFLAPRTARGIRMRNWFLGSRMFDLMLKYSDNAANDIELRDYPALVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0H9</accession>
    <name>A0A231H0H9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrethroid hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pytH_2</name>
        <name evidence="3" type="ORF">B7C42_05569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.88" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42370">
        <property type="protein sequence ID" value="OXR42370"/>
        <property type="gene ID" value="B7C42_05569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102209">
        <property type="term" value="F:trans-permethrin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012398504" evidence="1">
        <location>
            <begin position="35"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="29235" checksum="791FDFE79AAD65F1" modified="2017-10-25" version="1">MVVVGRGRTRRRVVRTVSVVAAVVVAGSVAVACAAETTSQAGPGEDAPKPTIVLEHGAFADASSWDGVIEKLRSDHYPVVAAANPLRGPAMDATGLRGLISHINGPVILVGHSYGGSVISAAGAGNDQVEGLVYVAAFLPAPGETALGLTNQFPGSTLPGAVNPVPVTNIDGSTGTDLYIQQDKFRDQFAADVAPDRAALMAARQRPIAQSALDEKATVAAWTEKPSWDVITTEDKNIPVAAQRFMAERAHAHVTEVAASHSVAVSHPDVVAGVIEQAAHDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0P3</accession>
    <name>A0A231H0P3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid 7-alpha dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.106</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">baiE_3</name>
        <name evidence="3" type="ORF">B7C42_05613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.106" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780704.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42412">
        <property type="protein sequence ID" value="OXR42412"/>
        <property type="gene ID" value="B7C42_05613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033988">
        <property type="term" value="F:bile-acid 7alpha-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20826" checksum="456B5A88BBD17805" modified="2017-10-25" version="1">MDSDAVSAISRLKFRYLRALDTKSWEDFADTMIPEATATYSEYLQFESRDAFLAFMRNTLGPHVITEHRCDHPEIDIDGDAATGTWYLADTVLIPGHNMLLRGAAFYNDRYVRCDDGHWRIAHTGYERTYEVVLSLSDLPSLRLTASRWGVITGEPGSVPDIPAVVSNIEDTPGGRVEEEPDEAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Q8</accession>
    <name>A0A231H0Q8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-dependent translational throttle protein EttA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ettA_3</name>
        <name evidence="6" type="ORF">B7C42_05617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42416">
        <property type="protein sequence ID" value="OXR42416"/>
        <property type="gene ID" value="B7C42_05617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="293"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="530"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="326"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="597" mass="65433" checksum="9571A2FE236D18B7" modified="2017-10-25" version="1">MANLINLEQVHKSFGITPLLDNVSLGVQEGERIGVVGLNGGGKTTLLEVLTGLEQPDSGRVSRINGLRIAVVTQRGVLPEGATVGEVVLAGLAEDARTDGVAEHEWAANPRIRSVLDGIGIADLGMDASVANLSGGERRRVALAAALVRELDLLVLDEPTNHLDVEGVQWLAEHLLARRSALVVVTHDRWFLDTIATRTWEVVGGKVESYEGGYNDWIFARAERARQADATEARRRNLARKELAWLRRGPQARTSKPRYRVEAAEALIADVPPPRDTVQLASFARKRLGRVVIELEDATLTTPDGRELVRDLTWRLAPGERVGLVGVNGSGKTTLLRALAGDAEPAAGKRIQGQTVRIGWLRQELDDLPTDMRVLEAVADVAERTMLGDKEISAGQLAERLGFTPAKQRTPVGDLSGGERRRLQLTRILMGEPNVLLLDEPTNDLDIDTLQQLEDLLDGWPGTLVVISHDRYLIERISDSTWALFGDGKLTNLPGGIEEYLRRRAALADTARRPSAQTETTAPATDSAAYRAARKEFGRLERTLEKLTEREERLHTALAEAATDPEKLVSLGAELKQVQAEKESTEMRWLELAEEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Z2</accession>
    <name>A0A231H0Z2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42518">
        <property type="protein sequence ID" value="OXR42518"/>
        <property type="gene ID" value="B7C42_05294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="25294" checksum="325FD82B7E33E4BF" modified="2017-10-25" version="1">MTPKSEDSPEPFWTLETRLASALLILAGFVGAAAYTHSEGYFVTFMTGNTERAVIGGFLGDYTLAAGAFALIVFFLAGVLVASLCRRHWWRNHPHGATMLATAALTAAAVLDTILYRHEADLGLVPILLVSFAMGSLNTSFVKKGEVSIPVTYVTGTLVKFAQGVERHMAGGTHREWLGYAVQWLSFAAGALIGGLVALVVEGADMLYTAVIASAIVAAYTWRADLSWVQRHSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H176</accession>
    <name>A0A231H176_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42608">
        <property type="protein sequence ID" value="OXR42608"/>
        <property type="gene ID" value="B7C42_05385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="14979" checksum="FAC26E2E54CFB023" modified="2017-10-25" version="1">MTTAETDAAAELDAIHAVVAAVDHAQRNENADEFLALFHPDAIWTTGAGKFLNGLDEISEFTRAVLPGATKDGYATYEVFFVRFIRPDVAAVKVRQRYWSNDNQLQSEGSPLYGMTKTDGRWLLTFCQNTPVIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H184</accession>
    <name>A0A231H184_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42606">
        <property type="protein sequence ID" value="OXR42606"/>
        <property type="gene ID" value="B7C42_05383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="29875" checksum="68F66B04EA93E106" modified="2017-10-25" version="1">MSDHPVDLRTDVAHPARMYDYFLGGKDHYEADRRAAETALANFPAVRLTARTNREFMRTATRYLAEQGVRQFLDIGTGIPTEPNLHQVAQEHACDSRVVYVDNDPIVLAHARALLVSAPEGRTTYVQADAADPEAILGSRELRDTLDLSQPVAISLMAVVHFVPGDVYAMVNTLMDALAPGSYLAMSHVTTDFDSGANDPDGMGRLLQVYSDQGIPVRPRSREEVARFFDGLELVEPGVEVIHRWRQEGIEHPADHDKKVSLYGAVGRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1F5</accession>
    <name>A0A231H1F5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoglycoside phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42666">
        <property type="protein sequence ID" value="OXR42666"/>
        <property type="gene ID" value="B7C42_05444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="74"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="378" mass="42334" checksum="DCFA75843FEAF6A3" modified="2017-10-25" version="1">MATEPTVENVSRLQSSSRDVTQLPALLADWLATVMPDGQRPEIFVVGGIDANGMSSETIVLGARWDEDGTRVTRKWVMRVAPTGSDVPVFPVYRLDHQAAVMEAAGRAGIPVPRVRYLENTATVLGAPFFIMDYVEGIVPPDVMPYTFGGNWFFDAAPEQQRLLQYATIEVLATLHSIPDAGTAFDFLVADRAGDTALRKNLTWLRAWYEFAVADIGRSPLVERAFDWLETYWPEQIAAGETVLLWGDARIGNVLYRDFRPAAVLDWEMTTVGPRELDVAWCVFAHLVFQELSGLAGLPGLPDVLRENDVRDTYRRLTGIELGDLRWFYVYSAVVWACVFMRTGSRRVHFGEMDRPEDVESLFYHAALLRALIGEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1I4</accession>
    <name>A0A231H1I4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF3817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_05042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776844.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42706">
        <property type="protein sequence ID" value="OXR42706"/>
        <property type="gene ID" value="B7C42_05042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="9">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="15193" checksum="5D6FC5BE761989A4" modified="2017-10-25" version="1">MSADHPTTPAATTTPAPAATPAPAARDTARIRSALTRYRVLAYITGVWLLLLCAEMVYKYLLLDDSSKAPHWLFYVGQIHGIFYMLYLVFTIDLGIKTRWKPLTLVITALAGTIPFLSFVCEHYRTRQVRAEFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Z6</accession>
    <name>A0A231H1Z6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">uvrD2</name>
        <name evidence="10" type="ORF">B7C42_05212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42874">
        <property type="protein sequence ID" value="OXR42874"/>
        <property type="gene ID" value="B7C42_05212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="310"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="7">
        <location>
            <begin position="646"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="723" mass="78382" checksum="DF2A84B26E2EA26C" modified="2017-10-25" version="1">MSVVPVMMECVPVPTSSTSLRLDGLDPEQAAAVRAPRGPVCVIAGAGTGKTRTITHRIAHLVSAGHVRADQVLAVTFTARAAGELRARLRALGLGGDAQTVQARTFHAAALRQLKYFWPQIVGDVPWKLIDSKFAVVAQAAQRVGLPTATENVRDLAGEIEWAKASLIAPEDYAGAAQRHHRDIPYQADKIAAVYTGYETLKNTPDGLLLDFDDLLLHTAAALEDYAAVAEEFRGRYRCFVVDEYQDVTPLQQRVLDAWLGDRDDLTVVGDANQTIYSFTGASPAYLLDFSRRFPDATVVRLERDYRSTPQVVSLANRVIGAARGRIAGTRLQLVGQRPDGPEPSFAEYDDEVAEATAVAKGIAGLLGRGVPAAEIAVLYRINAQSEVYEQALTEAGIPYQVRGGEGFFQRAEVRQAVQALRQAGARDDLPAARGPEVVTLVRAVLARLGLTAEEPAGAQARERWSSLVALVQLTEELAAHDPALEFAGLLRELAVRAESRHPPTVQGVTLASLHAAKGLEWDAVFLVGLTDGTLPIAHVLGEGGAVTDEAALEEERRLLYVGVTRAREHLRLSWALSRADGRRRNRRRSRFLTGLVPEDSPASMVAQRAGTRGGRSRRLPVCRVCGRSLLNSTDTLLGRCSGCPAEVDTELLGALQEWRRQRAEELQIKPFAVVSVKTLTAIAEQVPMDEDALAAIPGIGQQKSQQFGPELLAIVRSRVRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2A7</accession>
    <name>A0A231H2A7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42957">
        <property type="protein sequence ID" value="OXR42957"/>
        <property type="gene ID" value="B7C42_04843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="31291" checksum="73BC002D87A031CB" modified="2017-10-25" version="1">MPTLRDPVLVAAFEGWNDAADAASGAVEHLELIWDAEPLAELDSEDYYDYQVNRPTVRQVDGVTREIQWPSTTLSVCSPPGSERDIVLLHGIEPNMRWRAFCSDIIELIEQLQVTTVVILGALLADTPHTRPVPVTGTAYSKEAAEQFSLEQTRYEGPTGITGVLQDACVRAGVPAISFWAAVPHYVSQPPNPKATIALLRRVEDVLDIEVPLGELPAQAEDWESAVDEMTEGDEEVTEYVRSLEERGDAAVDLDDAMAKIDGDAIAAEFEKYLRRRGGGKGGFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2H6</accession>
    <name>A0A231H2H6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-methionine gamma-lyase</fullName>
            <ecNumber evidence="6">4.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">megL</name>
        <name evidence="6" type="ORF">B7C42_04939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777972.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43053">
        <property type="protein sequence ID" value="OXR43053"/>
        <property type="gene ID" value="B7C42_04939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="441" mass="46868" checksum="1F44EAA501E9D64E" modified="2017-10-25" version="1">MTDSVEPNDPAQNWSFETKQVHVGQIPDGTTNARALPIYQTTSYTFRDTDHAAALFGLAEPGNIYTRIMNPTQDAVEQRIAALEGGVAALLLSSGQAAETFAILNIAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVEDPDDLDQWRAAIRPNTKAIYGETVSNPQNHILDLPGLAEVAHAAGVPFIVDNTVPTPYLIQPLKHGADIVVHSATKYLGGHGAAIAGVIVDGGTFDWTVTDEQGNSRFPGFTTPDPSYHGAVFADLGAPAYALKARVQLLRDLGSAVAPFNAFLIAQGLETLSLRVERHVSNAQAVAEFLTERPEVTSVFYAGLPSSPWYERGRELAPKGTSAIVGFELAGGVDAGKKFVDALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLAAGVTPGLVRLAVGIEGIEDILADLRTGFAATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2I3</accession>
    <name>A0A231H2I3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43054">
        <property type="protein sequence ID" value="OXR43054"/>
        <property type="gene ID" value="B7C42_04940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="25596" checksum="A5E5616B83E5DA0E" modified="2017-10-25" version="1">MSEPVTIFPARRLEPAFEQICVRLRALQPGHPRVYAMAAMAEQGRRRWWRLADGAREGRIELMYRRHAAEMVSPGIAAEVVATALIHAVVGRVVALAVCDNRAWDPGLENLWVHTDNDGGLDWAGLSDTTIRVVAGDPLAGRPGVVTLPCDRALSVWLAHRCEAALTLVCESLYRCAGLSRARFWNLVGESIVGAATYVPELARTGADAGTERGQALLLALADRGLPVRRSCLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2P6</accession>
    <name>A0A231H2P6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777930.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43112">
        <property type="protein sequence ID" value="OXR43112"/>
        <property type="gene ID" value="B7C42_04998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="62" mass="7267" checksum="AF925720CE72D56F" modified="2017-10-25" version="1">MTEDDVWLTTDEVAARLKIPKKTLAVWASLGRGPRYVRMGRYRRYRVVDLIAWEQTQLEGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H338</accession>
    <name>A0A231H338_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sensor-like histidine kinase senX3</fullName>
            <ecNumber evidence="7">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">senX3_2</name>
        <name evidence="7" type="ORF">B7C42_04686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43264">
        <property type="protein sequence ID" value="OXR43264"/>
        <property type="gene ID" value="B7C42_04686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="531"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="652"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="808" mass="86186" checksum="D673C307DAB20612" modified="2017-10-25" version="1">MPVFKAKLGVRGQILSIALVPSLALLLVGMWVAASLLIQGRHSENWAAEIDRNTAPGMEFAVQAQNERRLTLLEIGGDTQHAGELTAQRARVDGAIRTIIAAGQRISSMDGSFDGALDAARSLTSQLPTVRQRADAGTLSADEAYSYFNRLTQVAAGGMELLTRAAPTSETAAEESNAARLFHAAEAMSKGNALAAAAVIGNGLSAEQLLEYSRQIGFYRSEIANLEPQLNPGAQATLRTLTKSDPWRRLATMEDALIQRGVSQQSPSATSAKAHDTSEPAPLPLSVADWQDAAAQVGNTLIDLWQNQNHYALRSATDHGKVTARNSLLGGGAVLVISVVAFLIAAGLATRTIRRLRRLRQETLALADDQLPRITEQLHTGRTVDLDTDILRLDFGTDEVGQVAEAFNRAQMAAVTAAVSEARTRTAVNALFLNIAYRSQLVIHRQLEVLDQAERELEDPVQLELLFKLDHLATRERRNAENLIILGGGQPGRHWRNPVPLLDLVRSAVAETEDYARVQVGRVPDGSVAGTAVADLVHLLAELMDNATSFSPPGSTVEVTGNVVGKGILVEVSDQGLGMAADDLQRMNETLSNPPDFSVTSLSDDSRLGLFVVALLAARHNISVRLAESHYGGIRAIVVIPSQLIATEAAHNDHRPTGPVAPPIAAGHGDTWAAVPAGPAATARADLAPSPQVPARRPASPDQYTAAAYPAPDPGPGPSPVSPSFHDPSPARPHGADKPPLPRRRRQQSLAPELAQAPAPSTSRAADPPPRPRSADQARNLMSAIENGTRQGRRRRPDTAPYEPEGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3C0</accession>
    <name>A0A231H3C0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B7C42_04228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43361">
        <property type="protein sequence ID" value="OXR43361"/>
        <property type="gene ID" value="B7C42_04228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="78"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="679" mass="70549" checksum="0B49046D3616B623" modified="2017-10-25" version="1">MVPPEPAKSGAARRFGGSAVERAGLAMLLIATAVMYLWNITVNGMGNQFYAGAAWAGSKNWEALLFGSLDPANFITVDKPPVSQWVMGLSGRLFGFSSASMLVPQAVMAVAAVALLYGAVRRITANHWMALLAGAALALTPVAALMFRFNNPDAVMVLLMTAAAYATVRALDRASTTWLMLAGAALGFAFLAKMLEGLMVLPALGVAYLLAAPASLRKRLLQLLGGLVALLVSSGWYVLLTLWWPASNRPYLAGSTDDNFMNLVLGYNGFARVLGRNHGGGAAPAHDPATAAHAAPPSGAHNGFGGFGGQVHGVQRLFTGEFGFEIGWLLPAALLAMVLVLVSRGRAPRTDRMRAAAIVFGGWIVIDGGVLSYMNGMVHPYYCLSIAPAVAGMFAIGIAELWNRRHTAFGRFGTAALLAVTGVWSVVLLHRNSGWYPELRWTILVVTLIAAVLLAVPWTYAAHRRLAAVVLTAGLIGGLAGSAAYSFATVATAHSGGGPTVGPAQASGRGGFGQTRPDPQLSAMLRATTATWAAATNGSSAAAALELDSDRPVMAIGGFSGSDPVPTLAQFQADVKAGKIAYYVVQADGRNQGPADVREQGVTGSRNPGTTGRAESATPGREQAAAGSVPGQPQPDTTENAGGPGGRNQHADITTWVTATFPAQRIGNATVYNLSGYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3J1</accession>
    <name>A0A231H3J1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid metabolism regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fadR_7</name>
        <name evidence="5" type="ORF">B7C42_04350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43483">
        <property type="protein sequence ID" value="OXR43483"/>
        <property type="gene ID" value="B7C42_04350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="24123" checksum="9463816320FBE386" modified="2017-10-25" version="1">MTHHSVAEHRIIGSVPKPSTHLERRKAELRQQIIDTAFACFADKGYHATGIADIATALGIGHGTFYRYFENKRDIIDHVIDDLAARIIEALGTENAPDAATSLDDYRHQLDRIGVALHRIFLEDRRVAQLLLFQATGIDPELTMRLYGLLDTADALTAGYLEHGVELGYLRADLDAANTAKAVTGMLLAAIVHGLRDPDPESTAGLARAIPRLLIDGVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M7</accession>
    <name>A0A231H3M7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43467">
        <property type="protein sequence ID" value="OXR43467"/>
        <property type="gene ID" value="B7C42_04334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="32" mass="3809" checksum="2244B26B2D3C2550" modified="2017-10-25" version="1">MHMSYLLYDFLLPYIGEQAATYWAQLFVVDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H418</accession>
    <name>A0A231H418_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(S)-2-haloacid dehalogenase 4A</fullName>
            <ecNumber evidence="2">3.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hdl IVa</name>
        <name evidence="2" type="ORF">B7C42_04459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43591">
        <property type="protein sequence ID" value="OXR43591"/>
        <property type="gene ID" value="B7C42_04459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018784">
        <property type="term" value="F:(S)-2-haloacid dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="25609" checksum="C94428827FDF7ADB" modified="2017-10-25" version="1">MSDRPKALLFDVQGTATDFHSTVVAAAAALLGQRYPGRDWSAFVNDWRAAYFRGTAAVGDHWVSVDSIYRAALDDLLTEHGMEVTSDVRAELNSAWKRLDPWPDAVPGLTRLRRRYTLATLSNADVDAVVSITRHCDFPWHAVFTAEMAGAHKPDPRTYRMAAHYLGAQPGEIMMVASHKYDIRAAAALGFRTAFVARPLEFGDPALADTAFSDEFDLNATDFEDLADRLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4P9</accession>
    <name>A0A231H4P9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetracycline repressor protein class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tetR_9</name>
        <name evidence="9" type="ORF">B7C42_04162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43923">
        <property type="protein sequence ID" value="OXR43923"/>
        <property type="gene ID" value="B7C42_04162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23813" checksum="D92AA2976A2FEF11" modified="2017-10-25" version="1">MSTRTGRPPRLSRAQIVAAARELIETHGVQALTMRRLAAELGATPMALYHHVPDKDALLLLLLDEVATAAVRPRLPQDPRERLIVAARAMHDVLAPVPWITEVLTADDLLSPAALWYPEAILDAAMDAGLDADRAVHAYRTVWYYTAGEILVRAAARRRRDDDRPVFRERVFADIDPEQFPRLAAVADRWSALTAADTYEQGLRALVDGLLPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4R2</accession>
    <name>A0A231H4R2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inner membrane ABC transporter permease protein YcjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ycjP_2</name>
        <name evidence="6" type="ORF">B7C42_03941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043034.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43706">
        <property type="protein sequence ID" value="OXR43706"/>
        <property type="gene ID" value="B7C42_03941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="31160" checksum="4112FA8264DE604E" modified="2017-10-25" version="1">MTTRERAVRTPKRRWGLTAAGVVIAAVFLVPYVVMVLGSLKPRSEILRIPPSYLPHRWRPGNYADMWHTPETPLPFNIVSTLAIAVLATLLVLAVAVPAAYHTARRRFPGRAVFLGAVLVTQMLQPAVLVTGLIREFFAVGINDTWFAMILVNAAFNLSFAVWILHSFFASVPVQIEEAAQLDGLSRPRILWRISLPLVWPGIVTATIFVFVSCWNEFAASLVVLTTPENQPLSVALTKFVGQYDTAWQFVFAISTVGIVPVVVLFALIEKRLVAGLTAGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4U8</accession>
    <name>A0A231H4U8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional activator NphR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nphR_1</name>
        <name evidence="3" type="ORF">B7C42_04130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43891">
        <property type="protein sequence ID" value="OXR43891"/>
        <property type="gene ID" value="B7C42_04130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="214"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="34537" checksum="D5D4825370232970" modified="2017-10-25" version="1">MISAMTMAESETTSAIEPHERVDYWAHLISSYQCTLGYRFPTSADFRGRTSLRRTESYQLVGWESDAVTYFRSPRLIRADPDPDYRLLVPITGTLTFRHGDDTGALPPGSACLVSTDEPFEMSMCEGSHGLIVTIAREDIRHRLNRREPPPRPLNLSTGIGGVAGAVAGTLYTQRAALTDHQFDTVAEQLVDLLCMQILGEAPSAPAQLAQVEASARRYIRTHAADPELTGARVAAALGWSLRQLQLAFSQAGTTPSEVIREQRLQIARDRLRNPAYRQRSVADIGAGLGFGSASSFTKAFRRRFDTTPGQLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H509</accession>
    <name>A0A231H509_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780968.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43944">
        <property type="protein sequence ID" value="OXR43944"/>
        <property type="gene ID" value="B7C42_04183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="216" mass="22997" checksum="B364F5136D3E8632" modified="2017-10-25" version="1">MTEVTTGAPTVAGRSAEFWGYLMWGLAGIVIAVPELAAVFDLADWPTISATIGHLEDAHSWVRLVVVFVIVVLAYYSLPQLAIPPQRPAAVAGRQTTANGRLTPDPDAVRTEGMGGYLVLACAALAVAVAFAGGARAVDPGTFTGAYVLYGTIAVMWVIVPSALSMFFAREVPFPTLFRTIGYLEHRAGFVAALLLGLLAILLIHLALYPWPRMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5G2</accession>
    <name>A0A231H5G2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hisF</name>
        <name evidence="11" type="ORF">B7C42_03773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777527.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44213">
        <property type="protein sequence ID" value="OXR44213"/>
        <property type="gene ID" value="B7C42_03773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR44213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="26770" checksum="B2141618DA7D8C54" modified="2017-10-25" version="1">MTLAVRVIPCLDVDAGRVVKGVNFENLRDAGDPVELAAAYDAQGADELTFLDVTASSGDRGTMIDVVTRTAEQIFIPLTVGGGVRTVEDVDRLLRAGADKVSVNTAAIANPEILREMSQRFGSQCIVLSVDARRVPDTGSPTPSGWEVTTHGGKRGTGIDAVEWAERGAELGVGEILLNSMDADGTKGGFDLPMISAVRAAVSVPIIASGGAGEVDHFAPAVRTGADAVLAASVFHFGDLTIPQVKDAMRTEGITVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5H3</accession>
    <name>A0A231H5H3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44022">
        <property type="protein sequence ID" value="OXR44022"/>
        <property type="gene ID" value="B7C42_03578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="426" mass="46123" checksum="E006969D3319949F" modified="2017-10-25" version="1">MLSWDEFGSALAAELAGLPVGALMVIEERGEFGRYVQFVHMDDNLYAELMSDRNPAVTQAQTPEQCQLIAGLGWREPGTSPESDSNWWTALKCPIRTADYRRLATMVVSGLRDGLGMSSPGDLTYRAWNSLEGNLPLEVSGLDIARAPEPPLARGAAWPPSADYSPLTSLCSVGPSALRGEDASDESADNSASSALAPEGIWEPPPLPGDSSSVGGSLTDCRGSSDYLRSPPFNPPAPPADLSEMTSSELVEFVRWIRNLAWGWNIYDIGSVITAAGLIDLVDLNPDGIAFTSNYSTGRFYLDFCGERVAYFDAPVANLPDFEHDGTRLRNAMARMTDALTAEYGKPMELPAPVGLERYGPYMEWVGAENTVTLSRDALSVRAVFRLNEGATVVCGEDEHARRVALFGRPLTGDDLRLRWTDSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5R3</accession>
    <name>A0A231H5R3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">prkC_1</name>
        <name evidence="10" type="ORF">B7C42_03761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44201">
        <property type="protein sequence ID" value="OXR44201"/>
        <property type="gene ID" value="B7C42_03761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="521" mass="54359" checksum="C9BC3845E38293E0" modified="2017-10-25" version="1">MIAGHYRLVERIGSGGTGVVWRAVDERLERSVAIKQILTQPSLPPGEKEIVRQRASREARNAARFQHPNAIVVFDITEHEGDPCLIMEYLPSQSLAVVLSSQGTLPLPQVARIGEQVASALVAAHRAGIVHRDIKPGNVLLGDNGTVKITDFGISKAKGDVNLTATGLISGTAAYLAPEVARGAEPSPAADVFALGATLFHALEGEPPYGTNPNPLALLYAAANGQLSQPRNAGPLTDLLLDLLSFEPEDRPSMTDVRDQLADFADQAADAESTRMLATHRGGARRQATRTLDRRTAQADISTAEMMATAAVLSEPEMQPVRPVAAGAHPTRSNPVPAAEPAPTRNAKPWVFAGGFAAGLVIVAAALYLMFGGAKTESPGSQVNSPAATATAQAGTSTQSVAAVGQTKSAGKTDVGSAAGVIQNFYDALVDQNTGTAWNLLTPAAQQVYGSQQAFASYWKQNQITAYNTIEGARGGGSSANSDGSVDMSVASITYGGQNKSIELRVVVGSSGKLLIDSDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5X7</accession>
    <name>A0A231H5X7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-cystine transport system permease protein YecS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yecS</name>
        <name evidence="6" type="ORF">B7C42_03799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777569.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44238">
        <property type="protein sequence ID" value="OXR44238"/>
        <property type="gene ID" value="B7C42_03799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="34931" checksum="BDECBC9C2BE454A9" modified="2017-10-25" version="1">MSAQPPAGSQAGPPEASMPEPIEAVPLRRPGRWIAAAVLLILLGLFVYGAATNPAYRWDTYWKYLFDRRISEGAVVTLELTVLAMAIGVVLGVMLAVMRLSPNPVLRSVSWVYLWIFRGTPVYIQLVFWGLFPALYKSIQLGIPFGGPSFVHWDVQDWSQPFIFAMIGLGLNEAAYMAEIVRAGVNSVGEGQREASVALGMSWGQTMRRTVLPQAMRVIIPPTGNELISMLKTTSLVTAIPLTTDLYGRARDIYGINFQPIPLLLVSATWYLAITSVLMVGQFYLERYYSRGVTRQLTGRQLRALATTQQTTEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H639</accession>
    <name>A0A231H639_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44473">
        <property type="protein sequence ID" value="OXR44473"/>
        <property type="gene ID" value="B7C42_03262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012940677" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="16029" checksum="9DB8D6D2EDDE00BE" modified="2017-10-25" version="1">MNIRALIGGSVAAVAISMAGGAVADAQPFVAANGPTVQNPADYLVGDTVYFNAGYANCSMHPNGDVGCDISPGIATLFGIPINNVAIDLPFLPAHPTFGLTGPLGRAGSRSIDSGPASDGYDYGGVINYGGATCSAGGRGAVQCSSKGHTFNFGWSGTNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H690</accession>
    <name>A0A231H690_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">infA_2</name>
        <name evidence="2" type="synonym">infA</name>
        <name evidence="5" type="ORF">B7C42_03853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500751.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44292">
        <property type="protein sequence ID" value="OXR44292"/>
        <property type="gene ID" value="B7C42_03853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="8264" checksum="E9C775D873605B02" modified="2017-10-25" version="1">MKKGAIEVQGHVVECLRNATFTVELPNGHQVLAHLSGKVRMNYIKILPDDRVLVELSPYDLTRGRILFRYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6J7</accession>
    <name>A0A231H6J7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775860.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44475">
        <property type="protein sequence ID" value="OXR44475"/>
        <property type="gene ID" value="B7C42_03264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="14763" checksum="85D95506A4077CC6" modified="2017-10-25" version="1">MSERPELAEALDLQPHPEGGWFRETYRSPVEFEPDGYDGARASATAIHFLLLPHEKSAPHTVRSDEIWLWQRGGPLLLNIGGDEVILGPDVERGQLLQAVVPAGVSQAARPAGDDYVLVSCVVAPGFDFADFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6M1</accession>
    <name>A0A231H6M1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ispF</name>
        <name evidence="10" type="ORF">B7C42_03229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44440">
        <property type="protein sequence ID" value="OXR44440"/>
        <property type="gene ID" value="B7C42_03229"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="16892" checksum="2E6FD428A4C7255D" modified="2017-10-25" version="1">MTDLTALRTGIGSDVHPIELGRPCWMAGLLFEGDDGCSGHSDGDVAAHALCDALLSAACLGDVGAVFGTGRPEWEGVSGAAMLTEVRRLLGESGYRILNAAVQIIGNRPKIGPRRAEAQKILGELLDAPVSVSGTTSDGLGLTGRGEGIAAVATALLVHDGRCSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H737</accession>
    <name>A0A231H737_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gltA2</name>
        <name evidence="10" type="ORF">B7C42_03463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44669">
        <property type="protein sequence ID" value="OXR44669"/>
        <property type="gene ID" value="B7C42_03463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="451" mass="49695" checksum="08F7B1F395407847" modified="2017-10-25" version="1">MPAENIKVAQTPSDANGAGDAKPVLSYPGGEYAMTVAQAVEGNDGIDLGKLLASTGYVTYDPGFTNTAPTKSAITYIDGEAGILRYRGYPIEQLAASSNFIEVSYLLIYGELPTQAQLEDFTDRIRRHTLLHEDLKRFFDGFPRNAHPMPVLSSAVNALSAYYQDSLDPRDPEQVELSTIRLLAKLPTIAAYSYKKSVGQPFLYPDNSLSLVENFLRMTFGFPAEPYEVDPEVAAALDMLLILHADHEQNCSTSTVRLVGSSDANLFTSVSGGINALWGPLHGGANQAVLEMLDDIKANINGGTVDAAVKDFIRKVKNKEDGVKLMGFGHRVYRNYDPRATIVKKTADQILGKLGVQDPLLDIAKALEEAALTDSYFVDRRLYPNVDFYTGVIYRAMGFPTRMFTVLFAMGRLPGWIAHWREMHSEPLKIGRPRQIYTGYGARDYGDIAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7X7</accession>
    <name>A0A231H7X7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Levodione reductase</fullName>
            <ecNumber evidence="1">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lvr_2</name>
        <name evidence="1" type="ORF">B7C42_02847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44892">
        <property type="protein sequence ID" value="OXR44892"/>
        <property type="gene ID" value="B7C42_02847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="25729" checksum="3BFEA870CD42F585" modified="2017-10-25" version="1">MAHNRFDGRIALVTGGTSGMGLATARRLRDEGARVIVTGRDPARLAAAAEELGPEALAIAADTTDLAALDALFDTIQNRYGRLDVLFVNAGIGFFPPTDAVTEADFDRVVGVNVKGVFFTIQKAIPLLSTGAAVVINASWALHRGMPFGSLYSATKAAAHNLARTLAAELGGKGIRVNSVSPGYIDTPALRSELPAAAQSAVAGDIVAGRIGSAEDVAAAVAFLASDEASYITGQDLLVDGGLVGLVPGTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H847</accession>
    <name>A0A231H847_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ykgO</name>
        <name evidence="4" type="synonym">rpmJ</name>
        <name evidence="6" type="ORF">B7C42_03008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780010.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45051">
        <property type="protein sequence ID" value="OXR45051"/>
        <property type="gene ID" value="B7C42_03008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="40" mass="4598" checksum="1E23FFF441562982" modified="2017-10-25" version="1">MKVRNSLRSLKDKPGAQVVRRGGKTYVINKKEPRFKARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8N6</accession>
    <name>A0A231H8N6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45152">
        <property type="protein sequence ID" value="OXR45152"/>
        <property type="gene ID" value="B7C42_03109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23278" checksum="E4A8B9C1B3259CE3" modified="2017-10-25" version="1">MTTTETKREEAVPEAETFTAHDVSMANAGSEGSGKGRSAGIAAQGRRAAESAVKVKTLAVGVIMVALVASVGVLGWQLHAKSGDISAMRGAEADRAHAERIALDYAVAAAQMDFKDLPGWQARLTKGTTPELTNKLKQAANSMDQIISPLQWTSTSTPIVAKVRSESDGKFAVDCFVSVMTKNTQAPQGIQSTATYRLTLDKNQNWVISDVGGIDSALAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8U1</accession>
    <name>A0A231H8U1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45285">
        <property type="protein sequence ID" value="OXR45285"/>
        <property type="gene ID" value="B7C42_02410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="40866" checksum="41313866F474CE30" modified="2017-10-25" version="1">MASGDDQDRDEGESRFGPPVSGFGPPLNDFGPPTGETGAIGWAPVGEPERPTLGWQPADAPAAPSVPPPPPQYRAPDSTAAPETVRHPAPEVPRAADTTRAPAPDSSPALETRRMPEPPRAPDAPRAPETVRYPDAGGAEADRGTWWRADDSGFPPTPPRETAKSLWDDDELAKKLTVPRGGAEQKSGSGSLWDDDELAKKLAPPRPLGQPQPEARPDRNIPVILAGAAGAVVSVIALVLIIVFATRSSDGDGTVAGGKSSPPSVAALSCPARTDGNVVIGNGPGDTNSGAAAILGFQHAFYADRSGAKAHEFVAPDASNVSTASTMQQAIDSLIPQGTTYCLRVETVTPEQFNVDLTEHRPDGTTTLYKQLVKTVNREGKNLVFSIDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H931</accession>
    <name>A0A231H931_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ESX-5 secretion system protein EccD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eccD5_2</name>
        <name evidence="6" type="ORF">B7C42_02589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45464">
        <property type="protein sequence ID" value="OXR45464"/>
        <property type="gene ID" value="B7C42_02589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="5">
        <location>
            <begin position="111"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="489" mass="49562" checksum="CA16AFD9B4A3014F" modified="2017-10-25" version="1">MTESSSSGVGAVDPELCRVSVIGGNTQLDVGLPATVPVAAYITDLVELIDSRNPDLTEHDEGAPVRAQHWTLARIGRDPIPPHQSLTDAEVFDGELLVLRSVTAKEAPALFDDVIDAVSRLTAESGNAWSPTAARRMGLGAGLIAVLVAVAVLVSGKGAGSWNGFIALGAGMLAAGAAVIVARRYPAERTTAIVLSLFAIALLGASAGLLTPGRVGSPHLLFSAVAALVVALALYSMTRAGSLVVAAVVTGAAVLAVAAAVRMVWDFDIAKIAVGVLISGLVLITMAPRAAVAAARLPVPPVPTAGGAIDPTDHEPRPTIADIGVIGATALPSAAGLERRARAANQYQSGILVGATLAAGFGAILGADPLGEARWQGLLLAAITAVVLCLRGRAYADLTQASTMIAGGAVVALVVIAGAAVAQEDRRAVGAGLLLIVAAAVVGFGVLGPRADVSPVLRRAIEIFEYLLIIAIVPLSLWLMDVYSAARNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H940</accession>
    <name>A0A231H940_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">guaB_2</name>
        <name evidence="7" type="synonym">guaB</name>
        <name evidence="17" type="ORF">B7C42_02500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45375">
        <property type="protein sequence ID" value="OXR45375"/>
        <property type="gene ID" value="B7C42_02500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="112"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="172"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="357"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="380"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="404"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="317"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR45375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="514" mass="53689" checksum="FABCC748B1064DF3" modified="2017-10-25" version="1">MSSPVMGERAVRPHTGGDDPNKIAMLGLTFDDVLLLPAASDLIPSSVETSSRLTREITLRTPLVSSAMDTVTEARMAIAMARAGGMGVLHRNLSAADQAAQVETVKRSEAGMVTDPVTCRPSDTLAEVDAMCARFRISGLPVVDETGALVGIITNRDMRFEVDQNRRVADVMTKAPLITAQEGVTAEAALGLLRRHKIEKLPIVDGNGRLRGLITVKDFVKTDQYPNATKDRDGRLLVGAAVGVGEDSWSRAMSLADAGVDVLIVDTAHGHQAQVLQMVAKVKNEVGDRIQVVGGNIATREGAAALVEAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRAADVPVIADGGIQFSGDVAKAIAAGASTVMLGSLLAGTAESPGELILVGGKQFKSYRGMGSLGAMQGRGQGKSYSKDRYFQDDVLAEDKLVPEGIEGRVPFRGPVNQVIHQLVGGLRAAMGYTGSQSISDLQQAQFVQITAAGLKESHPHDITMTVEAPNYTGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9E5</accession>
    <name>A0A231H9E5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsD</name>
        <name evidence="10" type="ORF">B7C42_02575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513444.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45450">
        <property type="protein sequence ID" value="OXR45450"/>
        <property type="gene ID" value="B7C42_02575"/>
    </dbReference>
    <dbReference type="GeneID" id="66719008"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="23642" checksum="CF6960E3E7F84385" modified="2017-10-25" version="1">MARYTGPITRKSRRLRVDLVGGDQAFERRPYPPGQHGRARIKESEYLLQLQEKQKARFTYGVMEKQFRRYYEEANRRKGKTGDNMLQLLESRLDNVVYRAGLARTRRQARQLVSHGHFLVNNRKVDVPSFQVSQYDIIDVKEKSLPTLPFQVARETQGDRPIPGWLQVVPNRLRILVHQLPERAQIDVPLNEQLIVEYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Z1</accession>
    <name>A0A231H9Z1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase YcgJ</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycgJ_2</name>
        <name evidence="2" type="ORF">B7C42_02066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45774">
        <property type="protein sequence ID" value="OXR45774"/>
        <property type="gene ID" value="B7C42_02066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="23009" checksum="D44EAFC2A116CE23" modified="2017-10-25" version="1">MTTATLGQRFFASWYPGFMSRVERAGQADLRRAQLSRASGRTLEIGAGDGLSVAHYPDGLDELVLLEPNPALRARLTTRADTRTGPVTVVDGDAHRLDFPAASFDTVTASLVFCSVRDPARALREVHRVLRPGGRFLFHEHVRGTGLRAGVQDVLTPLQRRLADGCHANRDFERLLAAADFDIEDIAHTRMPTMMPTIVPLVVGTARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Z3</accession>
    <name>A0A231H9Z3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <ecNumber evidence="1">4.1.3.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menB_1</name>
        <name evidence="1" type="ORF">B7C42_01914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784004.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45622">
        <property type="protein sequence ID" value="OXR45622"/>
        <property type="gene ID" value="B7C42_01914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="31069" checksum="A7C9B94CF5D792A7" modified="2017-10-25" version="1">MTGFETIRYERPAEKVARIVLDRAEARNAQSMRMLYELNDAFDRAAQDDSVSVIILAAAGPHFSAGHDLRETDAVQVVTDHRRVGTWCGFGCAGAESQMAVEKEMYLGLSERWRNLPKPTIAAVQGKVIAGGLMLVWPCDLIVATEDALFQDNTVSMGVAGVEFFNHPFEVGVRKAKEMLFTSDFLTAAEVHRLGMVNHVVSVDELESFTLRLASRIAEKPLFALKLAKEAVNVAQDNQGRANAMQTSFAYHQLCHSHNQQIHGLPIDPGFLQRTFAAKPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA31</accession>
    <name>A0A231HA31_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_4</name>
        <name evidence="3" type="ORF">B7C42_01987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45695">
        <property type="protein sequence ID" value="OXR45695"/>
        <property type="gene ID" value="B7C42_01987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="392"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="478" mass="51045" checksum="74252FD513426882" modified="2017-10-25" version="1">MNISMILEMAASAGNRPVLTVDGRSLTAAQLLRLARRAAADFADSSAVLYLGANHLAYPVALFGAVLAAVPFVPLNYRLGEHQLSALLARHPGARVLRPEDLDALVETDAAQPDPEPQPAPWDGEAVAAIIYTSGTTSEPKAALLRHRHLMAYLLNTMEFGAAAESDAALVSVPPYHIAGLTNLLSNLYSGRRVVYLPAFDPQRWLDTVRAERITHAMLVPTMLARIVTAAGGAEADTPTLASLAYGGSRMPRPVLERALAMFPATGFVNAYGLTETASSVAVLGPEDHRAAQASNDPAIRERLGSVGRALPGVEFDIRSAAGESLPIGQTGLVFVRGEQISGEYGARTALDADGWFGTRDLGRLDDDGYLFIEGRADDTIIRGGENIAPAEIEDVLLTHPGISEAAVIGVPDPEWGQRLVAVVVGAGDPEEIKRWVRERLRSSKTPDAIVFRAELPKTETGKLLRRNLVAELESSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA49</accession>
    <name>A0A231HA49_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">baeS</name>
        <name evidence="10" type="ORF">B7C42_02001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45709">
        <property type="protein sequence ID" value="OXR45709"/>
        <property type="gene ID" value="B7C42_02001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="145"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="38771" checksum="49D186F164ADA8A6" modified="2017-10-25" version="1">MSARAALDAGDRADLRASSLVTQLSDRLPRPLDRIRSIKLKLAVLMTFSGGLAFAWFSHRIGWLPPMTTVTAMLIALVSSQFLAHGIITPLREMTAAAQRMAHGDYTSRVRASSRDEVGQLAEAFNRMATDLAAADRQRRELIANVSHELRTPITALHAVLENLVDGVSEPDPKTLETALAQTERLGRLVSELLDLSSIEAGAIPLDREQFDIAPTFATVTAEAEVMTAALGRGIRFRSTIDPATATVYADRARLHQVLLNLLDNAARHGPAGGEVRLLAHTAGEHLVIDVEDDGPGIPPAQRERIFDRFTRGGSTDGGGTGLGLAIARWVVDLHHGSIAVAEPGSRIRVILPATAPHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAF1</accession>
    <name>A0A231HAF1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoglycoside phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45809">
        <property type="protein sequence ID" value="OXR45809"/>
        <property type="gene ID" value="B7C42_02101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="37731" checksum="2348B15694EC181A" modified="2017-10-25" version="1">MIDTARLTEWMDARDLPGRGEPAQARFLSGGTQNEIYLISRGEYRCVLRIPPAGAPPERDAGIAREWRITAALEGTDVPHTPAVAVCTDHSVLGRTFYLMGYVDGWSPMDSKRWPAPFDTDLDARAGLAYQLAEGIALLSRVDWCAKGLQDLGRPGGFHERQVQRWTDFFARHRGRDIDGMAEATAWLRAHRPLDYIPGLMHGDYQFANVMFEHGAPARLAALVDWEMGTVGDPKLDLAWMVQSWPDDTSAPEAAGVSYVDLRGMPSRDRLVAHYAAVSGRQVDDLDYYLILAKWKLAIVLERGFQRAGDDVKLQSFGPIVPKLMREAADLAESTEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAN6</accession>
    <name>A0A231HAN6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mycofactocin biosynthesis transcriptional regulator MftR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mftR_1</name>
        <name evidence="5" type="ORF">B7C42_02306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR46013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46013">
        <property type="protein sequence ID" value="OXR46013"/>
        <property type="gene ID" value="B7C42_02306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="22611" checksum="44883E2349817F08" modified="2017-10-25" version="1">MPRSGAEVRRRLQQAALELYRERGFDRTTAAEIAALAGVNERTFFRHFPDKREVLFDGEADLRTTLMQAVVEAPQGLSPFEVLLRAFRESVRNLERNRPFSDPRRQVIAATPALRERELAKHAGLTDAVAEALRQRDIDAGTADLAARTGWAAYQHAVRAWIDDPADSLDAHLCRAFDDLRGLAADAPIRADREDKSGPDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAT8</accession>
    <name>A0A231HAT8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Caffeyl-CoA reductase-Etf complex subunit CarC</fullName>
            <ecNumber evidence="6">1.3.1.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carC_4</name>
        <name evidence="6" type="ORF">B7C42_02148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.108" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45856">
        <property type="protein sequence ID" value="OXR45856"/>
        <property type="gene ID" value="B7C42_02148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="228"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="39781" checksum="DB858E1FC73A1BBE" modified="2017-10-25" version="1">MTAAPTADQRLFRTTTRDFLAATVPVDTVRRLADSPDGFDRDWWRRGAELGWTAPLVPERLGGGAVSGTPMADLALIAEEFGRACAPGPLLAVNTALTGLLRSTGDFETVIAEVVAGAAIATWAYYEPGAGLRSAPFETAATPDGAGFRLSGVKDRVEYGARADLLVVDAQGPEGSVQLLVATDAPGVTVTPVWTLDVVRRTATVVFDDVHVAGDAVVHRAPEAAVAAAEEQLLVAAALSAAEMAGAAQRAFEATVQWMFDRYTFGRPLASYQALKHRAADIATTLEACRATSWAAAASFGDDTANTAEAVSVAKSFVGATAGEIVQECVQIHGGLGVTWEHDLHLYLRRVTLGRALYGTPAEHRRRLTDLLETIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAU6</accession>
    <name>A0A231HAU6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778800.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45942">
        <property type="protein sequence ID" value="OXR45942"/>
        <property type="gene ID" value="B7C42_02235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="95" mass="10938" checksum="9D7E82B862443A5D" modified="2017-10-25" version="1">MTEEEQAIIDFAVLWLPYGGPPDEEILVRFGMSEQRFRARLADIVADRGTNVDRAWRRRAAVLLRTYLGSEPQLDLSRTRPPVDLRVVVQEGTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBE7</accession>
    <name>A0A231HBE7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenol hydroxylase P5 protein</fullName>
            <ecNumber evidence="2">1.14.13.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dmpP_2</name>
        <name evidence="2" type="ORF">B7C42_01104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.7" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46139">
        <property type="protein sequence ID" value="OXR46139"/>
        <property type="gene ID" value="B7C42_01104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018662">
        <property type="term" value="F:phenol 2-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="28466" checksum="06D756E5B0F89AE2" modified="2017-10-25" version="1">MTLGPDETGEIRLDAPTEWSSTVVGHHRLRHDLAVVRLIGEFVPFEPGQSVEVQIPQHPGMRRRLSPALPPSLDGKLEFHVRTVPGGWCSGSIVTETAPGDEWRISAPAGWLSVDPGTTDLVMIAGGTGLAPMRSLLLDLSRRPQPPRTHLFIGGRSPRDLYASDMLYLLAGEMPWLTVIPVVERAEDPNWVDQWYESCRVDVGFDVDEMLEGTLADVVGDMGPLLHHQVLVCGSPGMTQATLEVLVNTGTPAEAIRFDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBU6</accession>
    <name>A0A231HBU6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_4</name>
        <name evidence="2" type="ORF">B7C42_01380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46414">
        <property type="protein sequence ID" value="OXR46414"/>
        <property type="gene ID" value="B7C42_01380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="30219" checksum="317E6BD4A840DFC7" modified="2017-10-25" version="1">MQVTNGPDGSGAISSPSRMSAAADWTKAYWQDHPKRSLETFGRQITMGFSAVAELFVAIFRRRFPFGEFVRQCAFMASVAAAPTLLVAIPIGVIVSIQVGSVAQQVGATSFIGAANGLGIIQQGAPLVTSLMIAGAVGSAICADLGSRTIREEIDAMKVMGVDPMRRLVAPRLGAAMLVSVLLCGFVIFVGFLTGYIFNIFAQNGTPGSYIGTFASFAVTSDLLVALIKSLIFGLLAAIIACDSGLNTRGGPGGVANSVNTAVVLSALMLFGTNLIITQIYNALFPPQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCI0</accession>
    <name>A0A231HCI0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="2">1.1.1.302</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ribD2_1</name>
        <name evidence="2" type="ORF">B7C42_01445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781840.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46476">
        <property type="protein sequence ID" value="OXR46476"/>
        <property type="gene ID" value="B7C42_01445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="237" mass="25504" checksum="4911E77ECC2C85AB" modified="2017-10-25" version="1">MARPYVVLSVATSIDGYIDDAGPQRLLLSNAEDFDRVDQVRAESDAILIGAETLRRDDPRLSLSSERRREARIAAGKPEFPVRVVVTASGELDPGQRLWNQGGRRLVYTTTAGRERLGDRLAGRAEVVSLGSSVDFSALLDDLGERGIARLMVEGGGRIHTAFLAADLADELLMAVAPVLVGDSAAPKFLHPADFPGGSRRRMALVDITRLGDIAVLRYLPRPAPSDGSSAMMKDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCU3</accession>
    <name>A0A231HCU3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46803">
        <property type="protein sequence ID" value="OXR46803"/>
        <property type="gene ID" value="B7C42_01781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011221603" evidence="2">
        <location>
            <begin position="51"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="22487" checksum="45E0BD8452CAC428" modified="2017-10-25" version="1">MYRDQDQHMSFAPAHTPSAPAPRRMRRGSALTAVVAIAVLGLGSAVLAPAASADTDYGGGCVLYTDDPAATIDALHNHCSAEQQDQIFLDAPRGDVPTGVTNGWVTRPPVMEAVAPPFWIGKNFSTGPDGGTLTNRVTAAGIEGFPADVYSGPARLDGRPAWLLDYRPSITPQILDEIRQVTPGVWFGYSWWRGFFQTTLLLTFALTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCZ3</accession>
    <name>A0A231HCZ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46645">
        <property type="protein sequence ID" value="OXR46645"/>
        <property type="gene ID" value="B7C42_01619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="18603" checksum="7E3F8D033FDA176B" modified="2017-10-25" version="1">MREPIHLDCTNQTFDVVRLGTLRDAEANIRPATTGTQTYLAGEIHCGPDDAALIDQLIRRHPFVPAWVVFESKHIRVESVECYMRGSSLITCGQAGEYACAVLDGALTALTVVEPSPPRPTSEWIDCERARAIRDLVGDDRPVVEVPDGLQFVPFDPWAPEYVEANRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD64</accession>
    <name>A0A231HD64_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoid occlusion factor SlmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">slmA_1</name>
        <name evidence="6" type="ORF">B7C42_01767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775393.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46789">
        <property type="protein sequence ID" value="OXR46789"/>
        <property type="gene ID" value="B7C42_01767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="23976" checksum="1A24B4492F7EBA8B" modified="2017-10-25" version="1">MTRPTRPRSARGSGTELRAEILAATRELLARTGNADSVSIREVGGLVGVTAPSIYRHFADKDDLIDAAVAEVFEDLDAAIGAASDPTASPMSRLRQQGLAYVRFALQHPGQYRVATAASPGEGPSAVDVVLGSGAFQRFSHTVREAMDSGVIAPGDPMPLVLELWAAAHGIASLLIAKPHLPWGDAEAVADRVMAAACLGHAVLDVIGGETPDPDEGARWLAQLREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI0</accession>
    <name>A0A231HDI0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46954">
        <property type="protein sequence ID" value="OXR46954"/>
        <property type="gene ID" value="B7C42_00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="2">
        <location>
            <begin position="397"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="476" mass="50468" checksum="8B25C4A32B83B950" modified="2017-10-25" version="1">MTGLIAYGAYIPHHRLRLSEIGAVLGERRPAGTRAVASYDEDSTSMAVEAGRVALRGLPHAAGPSRIFFATSSPTYLDKTNAAVIHAALSLPRSTLAVDVGGAPRSALGALLAAADTADGALAVLSDVRTGRPGSADEMQGGDAAAALLFGRGSPDAPVLADLVTTASVTDEFLDRWRTPGATASRVWEERFGEHLYTPLAMESFTAALKQANITADTVDHLIVCGLSPRAVRQFIATSGVAATAVAPDLTQVVGNSGTAQPGVLLSDVLDRAVGRQTIALVVLADGASTLILRTTDALAARRPTIPAVAQQVADGDDTLSYATFLSWRGMLVREPPRRPEPEPPAGPPSHRSESWKYGFQGSRCEQCSTVHLPPVRVCYQCGATDRMHAEPMADRPARVATYTVDRLAHTPSPPMVAVVVDFDGGGRFRCELTDGGETMSIGDPVEMTFRRLTTTDGVHNYFWKARPARGRHEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDJ0</accession>
    <name>A0A231HDJ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator MalT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">malT_1</name>
        <name evidence="3" type="ORF">B7C42_00106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46990">
        <property type="protein sequence ID" value="OXR46990"/>
        <property type="gene ID" value="B7C42_00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="9240" checksum="4BEA4893920BD424" modified="2017-10-25" version="1">MELAGPPPRADPGPVCDRLTVRQREVLALLLTGLSNAEIADRLVVSVSTVKCHVRAILRAGGAVNRAEAIARLSRSVAPRRYDNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDN4</accession>
    <name>A0A231HDN4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776955.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47031">
        <property type="protein sequence ID" value="OXR47031"/>
        <property type="gene ID" value="B7C42_00150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="25574" checksum="2304976F9DAA05DA" modified="2017-10-25" version="1">MIKRLRFATRSPQLSFDAFARQWPLLCAAAADAPSGLRPVRVAVCTVLPELTGPGPRHDGVVAEWFRDIRHLRRHDRWRSGSDDAADVVTLPDSTAEVIAREHVLRGGEWLERRWDDGGDRLKHMAVAVRAASLTAEEFATRWRAHAGTVRRPGAATVAIPDAARGRAYVQNHPVAATRTAYDAVNEVYFDDVTGLRTRIDWFRDNGPSGPDGLFDRSWFLAAREVVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEJ5</accession>
    <name>A0A231HEJ5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xpkA</name>
        <name evidence="9" type="ORF">B7C42_00257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47135">
        <property type="protein sequence ID" value="OXR47135"/>
        <property type="gene ID" value="B7C42_00257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="8">
        <location>
            <begin position="48"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="7">
        <location>
            <begin position="624"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="831" mass="91489" checksum="CD8C3FFBA89C4383" modified="2017-10-25" version="1">MTDLASSEGRVPATDPTGADTAADNIGGSGGTTIAPEPYRLAEVPGPLSPDELADLDAWWRAANYLAVGQIYLTANPLLRTPLAAEHIKPRLLGHFGTVPGLNLVWAHANRAIRARDLDAVFVAGPGHGGPGPNACAWLEGTYSELYSNISRDGAGMGALFAQFSYPGGVPSHCAPETPGSFHEGGELGYSLLHAYGAALDHPDLTVFCVIGDGEAETGPLATSWHANKFLNPARDGAVLPILALNEYKIANPTLLARIPESELLSLLHGYGYDPIIVAGHDPAAVHQAMAAALDRSLDRIAEFQRAARESADGTRPRWPMIVLRTPKGWTCPPVVDGDQVEGTFRAHQVPLPAARSDDGHRRVLEQWLQSYRPAELFDEDGSPYPQLLRQVPAGPRRMSANPVANGGATMQDLRLPDWRRYGVEVPAPGATSHEATQVLGTWLRDVTAANRDNFLIFAPDELASNRLQDVLTVTGRNWQADIGEFDVKLDRRGRVIEVLSEHMCQGLLEGYLLTGRHGVFTCYEAFIHIVDAMFNQHAKWLDASSAVPWRRPVPSLNYLLTSHVWRQDHNGFTHQDPGFLDVVMNKQPSIVRVYLPPDANTLLSTYDHCLRSRHYVNVVVAGKQPQADWLSVDQARLHCARGAGIWEWAGHNDETGTTPDVVLACAGDVPTLETLAAAAILRERLPQLRIRVVNVVDLMRLLPADEHPHGLPDSEFDTLFTRDRPIIFAFHGYPWLIHRLTYRRTNHSGLHVRGYKEKGTTTTPFDMVMLNDLDRYHLVMDVIDRVPGLGTQAAGLRQDMADARLAARIWTREHGADIPEVADWRWPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEX8</accession>
    <name>A0A231HEX8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">kdpA</name>
        <name evidence="10" type="ORF">B7C42_00615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47490">
        <property type="protein sequence ID" value="OXR47490"/>
        <property type="gene ID" value="B7C42_00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="556" mass="58355" checksum="3E43869EB532BBC5" modified="2017-10-25" version="1">MSTTTAGVVFVATLIIALAAVHIPLGDYMYRVYSGTKHSRAERIVYRAIGVQPGVEQTWGVYARSVLAFSAMSVLALFFLQLIQGHLPLRLHEPGTEMTAALAWNTAISFVTNTNWQNYAGESTQGHLVQMAGLAVQNFVSAAVGMAVAVALVRGFARRHTGDLGNFWVDLVRGTLRILLPIAFVFAIVLIAGGAIQNFHLHDQVARTITGATQTIPGGPVASQESIKLLGTNGGGFFNVNSAHPFENPTAWTNWVEIFLILLIAFSLPRTFGRMVGSTKQGYAIASVMAALALISVTLTNVLQLRHHGTVPTAAGAALEGVETRFGVADSATFAASSTLTSTGAVDSAHDSYTSLGGMMTMVNMQLGEVAPGGVGSGLYGMLILAVITVFVAGLMVGRTPEYLGKKITPREIKFAATYFLVSPLIVLVGTALAMALPGERAAMANAGPHGLSEVLYAFTSAANNNGSAFAGLSGNTVWWNTALGLAMVFGRFVPIVLVLALAGSLARQGHTPESIGTLPTHRPQFVGMVAGVTLILVALTFLPMLALGPLAEGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF01</accession>
    <name>A0A231HF01_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative D,D-dipeptide-binding periplasmic protein DdpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ddpA_1</name>
        <name evidence="2" type="ORF">B7C42_00676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47551">
        <property type="protein sequence ID" value="OXR47551"/>
        <property type="gene ID" value="B7C42_00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="69"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="533" mass="57430" checksum="AED11EC4EBF20434" modified="2017-10-25" version="1">MVALVTACSSGGSGADDESATPVSGGTLTYASYRDATCMDPHVSPGDIVGELQRNVFDSLVAQKSDGTFAPWLASAWKISADGKEYVFTLRPDVKFFDGTPFDAAAVKANFEHILAPATKSQYAASLLGPYAGTDIIDDHTVRVRFTQPYSPFLQAASTAYLGFYSPKVLAEHPDELCGGGRYAVGSGPFRELSVTHGQGIEFERNPDYAWPPATARHIGPAYLDKLSVRYLTEDAVRTGALRGGQVDVIAGTPPADYQALQQDPAYRIVRGDAPGAPYTFFFNQSKEPFSDIRARQAVSAAIDIDGIVDSIYLGVYPRAYGPLSASTPGYDASVEKRPGYDVAKANRLLDELGYTGRDAQGYRIKDGHRFGLVLPYASNLVRESRDLVTQAVQQDLKKVGIELRLTPVDYGTYTTIIAANGYDLVGASWGRSDADVLATLYQSDRSVAKGGANNGKVADPQLDALLQQGRATADPAQRAAAYKQAQQLILDKAYALPIYVFTGVYTAAARVHGFGLDANGWSNFYDTWVEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF33</accession>
    <name>A0A231HF33_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">crcB_1</name>
        <name evidence="9" type="synonym">crcB</name>
        <name evidence="10" type="ORF">B7C42_00706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779614.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47581">
        <property type="protein sequence ID" value="OXR47581"/>
        <property type="gene ID" value="B7C42_00706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="120" mass="12314" checksum="1B8A25627835B9F9" modified="2017-10-25" version="1">MTVVLVFAGAVLGAPARYLTDRFVQARHDSLFPWGTLTVNIVGCLILGALTGGAAGSPVLAFAGTGFCGALTTYSTFGYETVRLLEQRSVFYAAMNVVISVIAGLGAALLGYAVTHAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFQ0</accession>
    <name>A0A231HFQ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamine transport ATP-binding protein GlnQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnQ_1</name>
        <name evidence="6" type="ORF">B7C42_00827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47702">
        <property type="protein sequence ID" value="OXR47702"/>
        <property type="gene ID" value="B7C42_00827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="36"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="29413" checksum="6A3F08D0AFEC6609" modified="2017-10-25" version="1">MTDAADATPGTASAGNTSDPGAATAAAASATVPPMISMRNVDKHFGDLHVLRDVNLEVPRGQVVIVLGPSGSGKSTLCRTVNRLEPIDSGTIAVDGVELPAEGRALAKLRADVGMVFQSFNLFAHKTILDNVMLGPVKVRRIDKKQARARALELLDRVGIADQADKYPAQLSGGQQQRVAIARALAMNPKVMLFDEPTSALDPEMVNEVLEVMVALAKEGMTMLVVTHEMGFARRAGDRVLFMADGRIVEDAAPETFFTAPASERAKDFLGKILSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG01</accession>
    <name>A0A231HG01_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47812">
        <property type="protein sequence ID" value="OXR47812"/>
        <property type="gene ID" value="B7C42_00937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9596" checksum="920519839E690217" modified="2017-10-25" version="1">MTPIDERIREVPMAPVECRQCGARVLARKSSWAQTSIQWDAESSAACVERHAAGALSDAAMRHCSQLRESIRSAAESGQLRVLDSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSJ5</accession>
    <name>A0A231GSJ5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pyrG_2</name>
        <name evidence="10" type="ORF">B7C42_08335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000190">
        <property type="protein sequence ID" value="OXR39597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39597">
        <property type="protein sequence ID" value="OXR39597"/>
        <property type="gene ID" value="B7C42_08335"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR39597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11632" checksum="EBBCE212D972DBDE" modified="2017-10-25" version="1">MSERHRHRYEVNNSYRDKIAQSGLRFSGTSPDGHLVEFVELPADQHPYFVATQAHPELKSRPTRPHPLFAGLINAALKYKAAERLPVDIEGEVTLGEGERVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSY4</accession>
    <name>A0A231GSY4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000076">
        <property type="protein sequence ID" value="OXR39733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39733">
        <property type="protein sequence ID" value="OXR39733"/>
        <property type="gene ID" value="B7C42_08194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="35309" checksum="9176576E7FD1E752" modified="2017-10-25" version="1">MRTSKTADQAKQGGTFAELAKSAVTIEELLGSAAPCLPPDVPESSLEIARNIETTSPGRRSIPLRWSFTHAAPPGEGDSTPKAPMARIIGAGGRGGGVPVKLYLALIWRAAGAPHTTNYSARLWAELLALPDPETKGARRVSDALRTLEQARLVSITRVPGEPSTVALLDESGSGAAYQLPSTAYYHAKTLAEKAKSAERKKKFEKEMDANLYSRLPLTLWTNGHIQAMSSAALAMLLILMSNSRASEGKEIWWSTQKFPERYGISPATRARGTSELQARGLLKVTKRLVANSPNNTRALTSKKVRSIYTLINDAKLSDSASQPDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSZ9</accession>
    <name>A0A231GSZ9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000082">
        <property type="protein sequence ID" value="OXR39708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036508131.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000082.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39708">
        <property type="protein sequence ID" value="OXR39708"/>
        <property type="gene ID" value="B7C42_08222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11194" checksum="C65060F4230F674A" modified="2017-10-25" version="1">MYLQFSPEVIAAVYTTNTATASTLAELMRLASVASEPIPAGADPVSVGLSAAFKSYKSGYYNITDNGISKFHEGNGKLPESIHRYEFGDSAGGARVKSAEPGIVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT14</accession>
    <name>A0A231GT14_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb_4</name>
        <name evidence="6" type="ORF">B7C42_08165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000070">
        <property type="protein sequence ID" value="OXR39764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782109.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000070.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39764">
        <property type="protein sequence ID" value="OXR39764"/>
        <property type="gene ID" value="B7C42_08165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR39764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="19824" checksum="1AF3B42DF4684639" modified="2017-10-25" version="1">MAGDTVLTVIGNLTDSPELRFTPAGAAVANFTVASTPRYFDRNAGEWRDGDPLFLRCNLWRQAAENLAESLTRGARVIVTGRLKQRSFTTREGDKRTVVELDVDEVGASLRYATATITRTSTSASGGLRTRRAVTTHRDGFGNPDTDTSTGFDQPAPSPSGGEDPWREPAMAEAAGGFGDDAPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT99</accession>
    <name>A0A231GT99_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000058">
        <property type="protein sequence ID" value="OXR39849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39849">
        <property type="protein sequence ID" value="OXR39849"/>
        <property type="gene ID" value="B7C42_08090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="29418" checksum="521E2D1EED3D10A9" modified="2017-10-25" version="1">MPVPEGTGTTQHHPTREAPERADTTSFLAGAGHTIDYDRYAVPDHHHLPCLACGLERARNDTQPDHYDDGLCTTCREDNQPGIADHTPGDHTTARCTFITNHHPPAAALALLRKDWRHTRNPVERATIETFADTLVAADTPHNTSSALEIDFGGGFDPFNPTHTLTDTELTQAIGTLERRIQLADNEAIMYGPAPGITNTPSTVDTEWLEQELTELHAELTRRSGLTVEQAGTEQTRRASHAHDTEKWSTSEQRSLGTRAAEADGPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTI1</accession>
    <name>A0A231GTI1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39930">
        <property type="protein sequence ID" value="OXR39930"/>
        <property type="gene ID" value="B7C42_07993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013031318" description="HD domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="74"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="25159" checksum="709A99BBFBB161E4" modified="2017-10-25" version="1">MFSRCVLIIRWSPALSPSAPPHDASDSGSTAARQSARLWVVVGAGVGYGFGMNEELRQWAESVARTHLQRLPKRWKHVQGVAGQAETAADLVDDPDMLVAAAWLHDVGYAPDLVNTGFHPVDGASFLRSIGAAERLCALVANHSCAHVEARRRDISLEWADERTPLRDALWWADMTTTATGERTDLQSRVADIERRYGSEHVVTQSIREAEPELADAVRRTESLLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTS9</accession>
    <name>A0A231GTS9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40016">
        <property type="protein sequence ID" value="OXR40016"/>
        <property type="gene ID" value="B7C42_07900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012443784" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="183" mass="19277" checksum="59ECF938CC6AA71D" modified="2017-10-25" version="1">MKPLSALALTVLAGTCLLTACTEHPSRGRPPDENLCEIAGFEPPFAVVDPCSADSVTSAALATMFTYRPAEGLDPRCAFEAATPLLDPEFARSGAPAAIALAPVTADMWARWRDQDIAVTATARATADDHPADTASRAARVVTVNMQPSYSTPALRLVVFAVAHRTKTSAGVRWLLSNVQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUH8</accession>
    <name>A0A231GUH8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40228">
        <property type="protein sequence ID" value="OXR40228"/>
        <property type="gene ID" value="B7C42_07653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045954">
        <property type="entry name" value="DUF6374"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19901">
        <property type="entry name" value="DUF6374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="8617" checksum="4325EF02F708DD26" modified="2017-10-25" version="1">MDLSRLEWARMNLEQVRAQLLDAAAFAKYLPPEQLERAAWKIGEGLRIYREETEPADAGPPGAACIDYRGAKRQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUX3</accession>
    <name>A0A231GUX3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative D,D-dipeptide transport system permease protein DdpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ddpC_3</name>
        <name evidence="6" type="ORF">B7C42_07548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40382">
        <property type="protein sequence ID" value="OXR40382"/>
        <property type="gene ID" value="B7C42_07548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="100"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="30862" checksum="FB0550799BD42D86" modified="2017-10-25" version="1">MVQVLAEAPEDIVTAAEPAIPRRRALLRRNAVRLARRPGFVAALAIVAGVIASAFVPSVFTSYDPYATAPAQRLRPPSATHLFGTDDVGRDLWARTLYGSGLTVQAALIAVGIALIAGLALGLVSGFFGGATDSVVMRGVDVLLAIPGLLSALAIVTALGFGTIPVAIAVGVGILPGFARTTRSEVLRVKTLPYVEAARAGGASWLRVLLRHVLPNSWGPVLALSVLDFGTAIIAVAALSFLGFGAAPPQAEWGSLVAGGRNFLVTAPWVSLLPGAVIVFTVLSLNHIAKTLQEWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUZ7</accession>
    <name>A0A231GUZ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40375">
        <property type="protein sequence ID" value="OXR40375"/>
        <property type="gene ID" value="B7C42_07541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="18860" checksum="EB09F6B791C26DBA" modified="2017-10-25" version="1">MGRTNFNEIACSIARSASIVGDSWTLLILRDAALGLRRFEELQRDLGIATNVLSQRLQRLVDQGVLRRHRYDQRPDRYEYHLTDKGQELIPVLFALMAWGDKWESGAEGPPLVLHHRPCGHRVEAKVTCDGCGGELTPESVVYQPGPGGRTGEGTALIATVLNSVGDRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV07</accession>
    <name>A0A231GV07_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40463">
        <property type="protein sequence ID" value="OXR40463"/>
        <property type="gene ID" value="B7C42_07401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="27933" checksum="D439085EAE5E8448" modified="2017-10-25" version="1">MGSITCSDPNPSVPDDNLSGVAENSPGLYRERRSRASAGAMVWQREVTAESATVLPDGCMDLLWLGGRLVVAGPDTRAYRSGAAAQTVYGIRFAPGTAPGLLGVRAQELLDRRAELDELWSSRRARVLADVVAAAPDPLRGLEEVARRCAAATAPPDPVVAQIVRRLDAGETVAATADALGLGARRLHRLSVAAFGYGPKMLARVLRMRKALDLTRAGVGFAETAALAGYADQAHMTREIRALTGRSPGRIRGAAACPENGQPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV21</accession>
    <name>A0A231GV21_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515548.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40477">
        <property type="protein sequence ID" value="OXR40477"/>
        <property type="gene ID" value="B7C42_07415"/>
    </dbReference>
    <dbReference type="GeneID" id="66722244"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="62" mass="6440" checksum="B2016BA7395D15CE" modified="2017-10-25" version="1">MNATTICLIFGLSLGFAAAFGGFGAFAVVLIFGALGLVIGRWLDGHVDLSGLIRSAQDRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVM5</accession>
    <name>A0A231GVM5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909812.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40638">
        <property type="protein sequence ID" value="OXR40638"/>
        <property type="gene ID" value="B7C42_07323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="501" mass="56020" checksum="693D4D99D3E42294" modified="2017-10-25" version="1">MITHIGDVVSADVPETARVVIIGAGFAGIGVAVRLKQAGIEDFVLLERELDPGGTWRDNTYPGVACDIPSMLYSFSFAPNPRWSHGYSDGGEILAYLREVIREYDLVDRIRYGRNVVGLDFDEGAGVWRVRAVIDGGEEVLEARSVVMATGPLSTASLPSIDGIEDYRGHTVHSAHWNPDLDVTGMAVAVIGTGASAVQIVPELVKRADRVAVFQRTPGWVLPRPQYRVPDWARVMYQRLPLTEDLARTALFWAHEAMGLGVVWPTQLTTLLELAARLQLRIQVDDKWTRRQLTPDYRAGCKRLLVSNTYLPALSSDKCKLYTFPIVRLTERGIQTVEGVEHRFDAIVFATGFEVIGKTGTPFPVRGRGGRLLGDEWAERAYAYKSVHVSGYPNLHFTFGPNSGPGHNSALIYLEAQIDYIVESMKMIERWGLRYLDVREIAQDRFNADLQRRLSRTTWNSGCASWYLTAEGFNPTMFPGLARQFRNQMEEVVLSDYHAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVT7</accession>
    <name>A0A231GVT7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40724">
        <property type="protein sequence ID" value="OXR40724"/>
        <property type="gene ID" value="B7C42_07148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1524" evidence="1">
        <location>
            <begin position="54"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="25343" checksum="EA40839385611F9C" modified="2017-10-25" version="1">MWSLCREIRDKTLPELIDTLRAKLDQDEPDVAFDGSPSRGRKGIADLRLNQFSRRYIYHLLARLTAYTEHESGRPDPFGELVDRSRRNPWDIEHIWPNVHERYADQYPTSQEFEEARNHVGGLLLLPADVNRSYQDKPFEVKAPHYARQNLYAASLNEAAYQHQPQFTAFLMREQLPFKPYTEFGKSEQEERVKLVLELARRVWNPDRLEQSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVU5</accession>
    <name>A0A231GVU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85B</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpB_6</name>
        <name evidence="2" type="ORF">B7C42_07250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777737.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40692">
        <property type="protein sequence ID" value="OXR40692"/>
        <property type="gene ID" value="B7C42_07250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011291943" evidence="1">
        <location>
            <begin position="45"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="353" mass="37823" checksum="F92269B8CCD6EDA7" modified="2017-10-25" version="1">MRRLRRQRSGRSGATPGRTLLALALALFVPLTAAVSGQLPRAAAAFDPSGFDFWVDSSMGPVKSRVFRAADGNTDRVVYALDGMRAREDLNGWEIETDIARLLTSWNINVVMPVGGQSSFYADWNAPSSFLGVAPGSGSSSGSTSGSGALQAFSAGPGKSYTYRWETFLTQNLRDALRDRLGFRADRNGVFGLSMGGSAALTLAAYHPDQFSFAGSFSGYLNISAPGMREAIRVAMLDAGGYNVDAMAPPWGPQWLRMDPFVFAPRLIQNNTRLWISAGSGIPTATDGPNMGTVNGMGLEALALVNTRAFQVRMGSLGAQNIAYDFPAAGIHAWNNWRDEVYRMAPDLSANIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVV4</accession>
    <name>A0A231GVV4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">16S/23S rRNA (Cytidine-2'-O)-methyltransferase TlyA</fullName>
            <ecNumber evidence="4">2.1.1.226</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tlyA</name>
        <name evidence="4" type="ORF">B7C42_07266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.226" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40708">
        <property type="protein sequence ID" value="OXR40708"/>
        <property type="gene ID" value="B7C42_07266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="29207" checksum="A85830A13DADF099" modified="2017-10-25" version="1">MDAELVRRGLARSREHAVELIGAGRVLINGAVASKPATAVEPNTPLLVREEPDEVQWASRGAHKVLGALEAFEPLGVSVAGKRCLDAGASTGGFTDVLLARGAREVVAVDVGYGQLVWRLRNDERVRVFDRTNVRALTPEAIDGPVELVVADLSFISLALVLPALAACCAPGADLLPMVKPQFEVGKQRVGSGGVVRDPALRAEAVTEVAAAAAGLGLRTRGVVASPLPGPSGNVEYFLWLRKESQGKETSDTDSPEIESEPDISELVQRAVEEGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW74</accession>
    <name>A0A231GW74_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40877">
        <property type="protein sequence ID" value="OXR40877"/>
        <property type="gene ID" value="B7C42_07012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="119"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="26714" checksum="D154A69F21CCE4C3" modified="2017-10-25" version="1">MTVQQGRSEQGVEYGGGARCLHAQHPLDDPVRTSLRGAHSRFATWVGRIGRYDPAVSAFIGHPPSLDPQDWADLATVLGPGGGTALRGYGHRPPPDWRVLRTLETVQMDGSALRVAHDPDAVRLTGADVPEILELIARTEPGPYLARTIEMGAYLGLRVDGRLVALAGERMHPPGWTEISAVCTDPEFRGRGYASRLVRAVGAGIRARGEIPFLHAVAGNTTAIALYRTLGFTVRKRSLLTFVQAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWW4</accession>
    <name>A0A231GWW4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiocerol synthesis polyketide synthase type I PpsC</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ppsC_7</name>
        <name evidence="2" type="ORF">B7C42_06835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41065">
        <property type="protein sequence ID" value="OXR41065"/>
        <property type="gene ID" value="B7C42_06835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="32479" checksum="CCD1301F0F66DB53" modified="2017-10-25" version="1">MKAVVIRTFGPAEGLAVVDLPAPAPAAGQVLITTEAIGVGGVDAVIRRGTIGGYGFEAGHVPGSEVAGIVTAVGDEVDPSWIGRRVWAFTGFGGGYAEQASARVRDVLPLPPDLSSVDAVTLGSSGVVAHFALAHARFCPGESVLIRGAAGSIGVTAVQLASRGGAGAVAVTTSSADRGDRLRGLGATHVLDRSGKGGADTPAGYDVIVDVVAGADLPSFFAHLNPNGRMVAVGVVGGHPPADFGMQMMAAFRKSLSFATFSADTVAESDRRAVRAEQFAAAGRGELRTVVHEILPLDDAVLAHRKMDAGEVFGRIVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX05</accession>
    <name>A0A231GX05_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 monooxygenase PikC</fullName>
            <ecNumber evidence="3">1.14.13.185</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pikC_2</name>
        <name evidence="3" type="ORF">B7C42_06743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.185" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043649.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41147">
        <property type="protein sequence ID" value="OXR41147"/>
        <property type="gene ID" value="B7C42_06743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="43944" checksum="AC4B5F126807DD73" modified="2017-10-25" version="1">MGSPVDTDGPRILLDTPEFAADPHGTYREMRRRYGSLVPIELSPGVPATLVIGYHTALRILNDPEHFPADPRAWQDTIPEDCPVRPMMQWYPNALRNAGNVHLRYRQAYTAAVDGIDLHALHSTVEKIAIPLINSFCEAGSADLVSQYAFPLVFESLNRMVGCSAELGQRVATGMAALFDTVNAAWGMEHLSQALMELIHLRRADPGDDVTSRLAHHPANLSDEEMLYNLISFYGAGIEPQQNLIANTLLLMITDDRFGGGMLGGSLSTRDALDEVLFKDPPMANFSISYPRQPILIDNAWLPAHQPVVISLSACNNDPVIAGGDRTGNRSHLAWSAGPHACPARSVAYLVVQDAIDQLLDALPEMRLAVEPSEITWRPGPFHRAMAALPVTFPASPPLNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX24</accession>
    <name>A0A231GX24_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenolphthiocerol synthesis polyketide synthase type I Pks15/1</fullName>
            <ecNumber evidence="6">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41128">
        <property type="protein sequence ID" value="OXR41128"/>
        <property type="gene ID" value="B7C42_06723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1673"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1827" mass="189533" checksum="CACC05C917F3FFD5" modified="2017-10-25" version="1">MNTPDTSNEERLSRYLRKLTGDLRAAKKQIRELEDRAGEPIAIVGMSCRYPGGADTPDRLWDLVAAGADAIGPFPADRGWDLDRLFDTDPDAPGTVYTREGGFLDTAGDFDAAFFGIGPRAAEAMDPQQRLFLEAAWEALEDAGLDPVSLRGSDTGVFAGVIHQDYGPRVGSPGLTAETEGHAFLGVSASVLSGRVAFTFGFKGPALSVDTACSSSLVALHLACQALRQGDISLALVGGVTVMSDPGLLIAFGRQRALSPDARCKAFAAAANGTGFSEGLGMLAVERLSDARRHGHRILAVVRGSAVNQDGASNQLTAPNGPAQEKVIARALANAGLAPADVDAVEAHGTGTTLGDPIEAQALIAAYGRDRTGDPLRIGSLKSNIGHTSAAAGVGGVIKMVQALRHEILPATVHVDAPTPHVDWSAGAVRLLTAAEPWPAGDRVRRAGVSSFGASGTNAHVILEEAPAPEPAAEPADPAPDQDVVASGLTPVLISAKSEEGLRGQAGALVRWVDEHPDLTVDDLGYSLLTTRTRFEWRAAVLVDGRDALRAALSDLAEPGAVSSAVVTGRAVTRKTALLCTGQGAQRADMGRELYEAFPAFAAALDEVCAQFDPLLGVPLRQVMVTGADASALDHTAFTQPALFAYEVALYRLLSSFGVAPDVLIGHSIGELAAAYIAGVWTLPDACRLVAARGRLMGQLPTGGAMLAVAAGESEVTEMIAGDRSVCLAAVNSTAAVVISGDADAVAAYRARFTERGRKTAPLTVSHAFHSHHMDPMLAEFESVAREVEYQRPRIPLVSNVSGRLAGEEVLDPGYWVRQVREPVRFAAGVDSLVAAGVRRFVEIGPDAVLTAMTGQCLPEELDGEPTVVAAARRGRGEVGQFAHCLARMYTAGAEVDWSVFFAGRTVKRVPLPTYAFQRRRYWLPSASGAGGGESAGVRAIDHPLLAAVLPMAGGGFVLSGHLSPRAQPWLADHVIGGVMLLPGTGFVELALRAGAEAGCPVVEELTLRAPLVLSAMEGVPIQIVVGAIDSESSRRPISIYSRGAHDPDGAWELHAQGLLSATDAAAPAPEIWPPAAATAVDIAYGKFLSRDYALGPAFRGVRALWRRGEEVFADIAVDADTGVRADGFGIHPALLDATLQAGLLADVLEIGAGQVVLPFSWESVSLFTTEASLLRVRLTVSGSSVSIGVTDGHGRPVLSGSVTMRATPVAQLAAAALADPVLELVWSPATAEAGAAEASVGWWDRLEPESPVPAVVVVEAGHPAGAGVVAATHTEVARVLGVVQEWQAGDRFASSTLLVVTHGAVALPGEDVTDLAGAAVWGLVRSAQAEEPGRIVLADIDSGLDEHLAARVLGVGEPEVVMRAGVPHTARLTRSAPVSEPDGDAAAFGAGTVLITGGTGGVGAVVARHLVRAHGVRSLLLVSRSGMRAAGAAALCDELEQAGAQVKVVACDVADAGAVAGLPAHVPARWPLSGVVHAAGVLDDGVVASLTPQRIDTVLAPKVDAAWNLHEATADRELAAFVVFSSMSGTVGGPGQGNYAAANTFLDGLAAHRRARGLAAQSVVWGPWARASGMAGHLDAGDAARMNRAGFTALSDDAALAGWDAALARGTAHPVIVALDSAAIRDRAAAGMLPPLLRTLAPPALRATKEAAPAIAPLPQRLTGLDAERQGQVVLETVREHIAAVLGHDGAAAIAPERTFQELGFDSLGAVELRNRLKSVTGLSLSAAVVFDYPTPKALAAHLHTQLAGAPVDVRPRPVDAVLDDLEAALALGEWDDEQKRRIVARLQSVAASWVARTDPDDLLEDDVENASEAELFAILDRELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXD0</accession>
    <name>A0A231GXD0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41259">
        <property type="protein sequence ID" value="OXR41259"/>
        <property type="gene ID" value="B7C42_06657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393888" evidence="1">
        <location>
            <begin position="27"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="34016" checksum="E4C3E416AAFFC650" modified="2017-10-25" version="1">MRVARVIATVAAGLGMLWVATPPGSADEPGAGFPAVAAHEFTVAQEELAAAVQCDSGARSGRPTVLLIPGTGGTPDEIWSWNYEKALPAAGYGWCTVALPDRALGDFAISAEYAAYAALQAHRVSGRPIGIVGHSQGGAMAAWIAKFWPQVAAVTSDVIPIAGPLGGSAVADSLCAGGECAPIAWQMGTRSQVTRAFANAPVPDGPAFTSIQTMQDELVLPQPQAGSMRGGRTIMVQQVCPGHLADHGMLVFDPVAYALVLDALGHPGPADPSRVDRAVCAQATLPGFDPAGYTKFSSTVSALMFGLLDTRNWVPAEKPLPAYAAPYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXI4</accession>
    <name>A0A231GXI4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41221">
        <property type="protein sequence ID" value="OXR41221"/>
        <property type="gene ID" value="B7C42_06619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="31654" checksum="43A63E2190BDC4EF" modified="2017-10-25" version="1">MNPTAIPALRRVPAATPISEILAVVEEDGGVIIEGLLSADQIARFNADIDNDLANLAPGGTHTDEIAKEFHGANTKRLTNLVTRSKTFREEIIDHDLVHNLCDAVFLEESGTYWMTTAQVIEIGPGNRAQMLHRDLENWYPFVGMGPQGPEVVLNFLIALTEFTEQNGATRVIPGSNHWPDFEDRGTPEQTVPAVMRPGDALFFSGKTVHGGGANITTDEHRRAVGFAFNPGFLVGEEAYPFLVDRDLARSLPPRVQGVLGFRSQYPKGTPGLWMVNYEELGDYLDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXP7</accession>
    <name>A0A231GXP7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780411.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41394">
        <property type="protein sequence ID" value="OXR41394"/>
        <property type="gene ID" value="B7C42_06537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16439" checksum="279971587DB3A5FE" modified="2017-10-25" version="1">MIQVRPRPIVQEAIDAASAACDCTGTRALRVVLHAGVSAMWSAIRATPQRQVHTLDLTISALRRRWEGEADCSGLSATEWLRDLDAEVGAALDACAERSNTQWIEPVTAISAYVLAVIQGAVLRWLADGDDETTLVVLDDLVSTLITKAVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY53</accession>
    <name>A0A231GY53_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41554">
        <property type="protein sequence ID" value="OXR41554"/>
        <property type="gene ID" value="B7C42_06447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046038">
        <property type="entry name" value="DUF5996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19459">
        <property type="entry name" value="DUF5996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="37649" checksum="8467832A444ABDC2" modified="2017-10-25" version="1">MTRIDIDNEGTTDMPETNSTVWPRLRVAEWADTRETLHMWMQVVGKVRLAHAPLLNHWWQVTLFVSPRGLMTPAIPYGDRLFDIEFDFLADRLVIRADTGDMRSVALEPKSVAQFYAETMRALDELGLRTRIQGRPNEVDPSIPFAEDTRHASYDPESARAFWRQLVHANRALDEFRSGYIGKSSPVHFFWGAMDLAYTRFSGRSAPEHSGGAPHCADWVMVEGYSHELSSCGFWPGGGEEGAFYAYAYPEPEGYRERQLQVPGAGYDAALGEFVLPYETVRTADDPSALVAAFLHETYAAAADSGQWDRRELECDPHRWAEKRAAAPWSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYF9</accession>
    <name>A0A231GYF9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783644.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41615">
        <property type="protein sequence ID" value="OXR41615"/>
        <property type="gene ID" value="B7C42_06256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="119" mass="13421" checksum="69D284B6A446F023" modified="2017-10-25" version="1">MDNLRDAERRLQTAQLAGDVEALDRLLDDRLIFTFGANVQTKADDLELHRTRAQVVTKVAEEELTVLTDGRTGVTWFLGTIEGTVSGTPFAARMRYTRTWLYDETHGWRIIAVHASTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYP2</accession>
    <name>A0A231GYP2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41718">
        <property type="protein sequence ID" value="OXR41718"/>
        <property type="gene ID" value="B7C42_06060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="25565" checksum="70469E4E421859F0" modified="2017-10-25" version="1">MARPSSPSSWVIGRRASVIAECAARRFAASREKRVSRSSVNCGPDPVRSLAISTTPLGWYSAGIAAIRPSAVARSKYASNSRKDAVSPRCHSDVENLVTAIRTPARRSDDRTFVKLSRERCAVFTSATKARATAFNSGSTAAPVPRKPSTVCSPPCSSSAKTARTDRASSTGTSATNSMAALIVGGRRLGDSAAARVKYLENEKGLARSMYRSSTSRSCCSVNVTSPCISSENSPIRPDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYV8</accession>
    <name>A0A231GYV8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780816.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41765">
        <property type="protein sequence ID" value="OXR41765"/>
        <property type="gene ID" value="B7C42_06107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="73" mass="7885" checksum="C6297F8291FCE37E" modified="2017-10-25" version="1">MTDRPTGAQRPGDSHSADRPAKGRARSAAEAARLARVFGETLPRTSSDERAPDGELPRSSDDWLRAQVPPHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZC4</accession>
    <name>A0A231GZC4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41950">
        <property type="protein sequence ID" value="OXR41950"/>
        <property type="gene ID" value="B7C42_05934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="1">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15024" checksum="83C6E5EE9B6B44BF" modified="2017-10-25" version="1">MIRATARIVRPMTATDLVGTWELVSYYDIDDADVRSEGPLGPAPRGLLIYTAQGSVSVSMMRTGDTTAAPPFMGYAGTWRTTGMAVVHAISVCSNPAWAGTEQVRQLSLDGDVLTLIGAAQVDGRTQRRILTWRRSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZG6</accession>
    <name>A0A231GZG6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_06000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42016">
        <property type="protein sequence ID" value="OXR42016"/>
        <property type="gene ID" value="B7C42_06000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="41682" checksum="7D54FBD396F110D5" modified="2017-10-25" version="1">MGSSADSDAERGPQGEPSVPEPIAAAERAASESAGARHPHGRPGPRFDRNSPFVIGVTGGLGVLLAIGIVQMLATARQALVLVGVALFLAIGIEPVVAWLHRHRLPRWAAVAVVFGCATLLVAGFLAAAITPLIIQGGDLVDHATDQLHDLENQYPLIRSWSQRLHLDQELQHGLTDNPSLRHGLLGAGERVFGVLASALIVAVLTIYFSANFPRIRHSLYRFFPQSRRPRAILLGDAIFAKVGGYVLGNLVISLITAIATFVWLTVFSVPYPLILSVLVALLDLVPLVGSTVAGLIITAVALTVSLPVSIATAGFFLAMRLLEDYLLVPRIMDRTVRVPAVVTVVAIILGGALLGILGALLAIPCAAAVLLIVQEVVYPHLDGTTDRPPTGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZX3</accession>
    <name>A0A231GZX3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42149">
        <property type="protein sequence ID" value="OXR42149"/>
        <property type="gene ID" value="B7C42_05748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="29524" checksum="BC61DCFB8C04D55F" modified="2017-10-25" version="1">MESGAPVDLRQNQPHTARMYDYYLGGQDHYSADAEAAEKVVATWPGVRTAAQQNRAFIHRVTRFLANAGIRQFLDIGTGIPTEPNLHQVAQEVAPDARVVYVDNDPIVLVHARALMISSPEGRTNYISADVTTPEAILDAPGLHETLDLTRPVAVSLNALMHFVPDEQDAYGIIETLMKRFVPGSYLVMTHVTPDFDPAAIGTVVEIYRRSGLPCQVRTRDEFARFFDGMELIEPGVEVPHRWHPDGVAPPKKMDAQVSAYAAIARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H028</accession>
    <name>A0A231H028_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42172">
        <property type="protein sequence ID" value="OXR42172"/>
        <property type="gene ID" value="B7C42_05771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045730">
        <property type="entry name" value="DUF6084"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19562">
        <property type="entry name" value="DUF6084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="23760" checksum="FEC3CC397C1AED22" modified="2017-10-25" version="1">MSPAYATTFAVLGMKPEPYTVTPILSARIRIASVGDEPVHAIALRAQVRIEPNRRSYTDAESAGLLDLFGPRDRWDHTQRSFLWMHCATTVPGFSGGAEVDLPMPCTYDLEVAGSKYLHALRDGEVPLLFLFSGTVFIRGSNGFAVQQIPWDRDDRYRMPISVWRELMAAHFPGAGWLRLHEDTLAALAAYKGEHGLLGFDETVARLLAGAQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H043</accession>
    <name>A0A231H043_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase 2</fullName>
            <ecNumber evidence="3">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB_8</name>
        <name evidence="3" type="ORF">B7C42_05824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42225">
        <property type="protein sequence ID" value="OXR42225"/>
        <property type="gene ID" value="B7C42_05824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="32030" checksum="09B743028B8A0BC8" modified="2017-10-25" version="1">MVDDPHAGAGPAGPPWSQGELLRLMDVQSCGAGHYVAPAHGPTVRNVVEAGQMLGDAIVAAAKEVPRQRVVSASMIFTRVAAHDAPLDVDVEVLHSGRTYSTAQVRIRQHDTLRCAGTVLLDAGAPDLIRSAAPMPRVEPPEKLASLDIPGTEVDGRDMRVAGDGYSPDPGHVGPPELFVWTRYRDAPEAGHLHAALLAQSCAHWTVAAALRPHPGFGESMAHSAISTGITMATITFHDDADVTQWLLYSTRVVYAGRGHAQSEGRVHAADGRLMASYSVHAMVRAFRSADTAARTRAGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H052</accession>
    <name>A0A231H052_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-hydroxybiphenyl-2-sulfinate desulfinase</fullName>
            <ecNumber evidence="1">3.13.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">soxB</name>
        <name evidence="1" type="ORF">B7C42_05842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.1.3" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42243">
        <property type="protein sequence ID" value="OXR42243"/>
        <property type="gene ID" value="B7C42_05842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018740">
        <property type="term" value="F:2'-hydroxybiphenyl-2-sulfinate desulfinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="36599" checksum="D988C55F97258155" modified="2017-10-25" version="1">MTDTLWYTRCPVPTASGLAHSLGWLGDAAQRGGLTFGVLQDAGPELAGFHFDHGLAGLVREGGNVPALAARAAGSPTRLIGLTWIDESQAILVGPDSAVASPADLAGLRIGIPTWAQDQARSFPRAMALHGFANALRLGGLTLADVTVVELAVERDPQVRTDVQQRDRRVTWGAEELLRGEVDAIYVKGARAQEVAAEHGLRVAVDLDATDSKRLRVNNGTPRPITVHQQLLDTRPEVVVDFLAQSLRAADWAGDNLDGVRAVLQRETLSGPEGVVAAYGEDFHRSLHPSLDEERLELLGVQKQFLYTHGFLATDFDLASWIAPEPLARARELVATGRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B3</accession>
    <name>A0A231H0B3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42286">
        <property type="protein sequence ID" value="OXR42286"/>
        <property type="gene ID" value="B7C42_05485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="83"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="165"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="23526" checksum="8F41B207BC7B7FBC" modified="2017-10-25" version="1">MPTITSISPSSGPTTGGTSVTITGTGFTGPTTVRFGTTATTFTLNSPTQITAIAPAGSVGAVQVTVTTSAGTSNGATYTYLAVPALSGINPSQGATTGGTTVTLTGSGLTGVTAVNFGSTPATSFTVDSDTQITAVAPAGTGIVSVTVTGPGGTSNSATYVYVVVPSITSISPTSGPTTGGNNVTITGTDFTGPLTVRFGTTATTFTVNSSTQITAVAPAHAAGTVQITVTGSGGTSNGVAYTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0N6</accession>
    <name>A0A231H0N6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plsC_6</name>
        <name evidence="2" type="ORF">B7C42_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780699.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42409">
        <property type="protein sequence ID" value="OXR42409"/>
        <property type="gene ID" value="B7C42_05610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="24251" checksum="70B437910AA55A83" modified="2017-10-25" version="1">MWYRLLKFVLIGPVLRILGRPKVEGLHHVPKNGPVIIAANHLAAIDSLYLALVLPRRITFLAKSQYFDEPGWRGRINRWVMTATGQVRVDRSGGSASADALAAAVGILESGGVWGIHPEGTRSPDGRVYRGRTGVIRVAMRTGAPVVPVALSGTDRVNRRGRRLLRFGKVRIVFGAPRTFLPVDRDAVRTATDDLMAELAMRSGRRYVDCYAAHFRTESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1D5</accession>
    <name>A0A231H1D5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">drrB_8</name>
        <name evidence="10" type="ORF">B7C42_05452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778233.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42674">
        <property type="protein sequence ID" value="OXR42674"/>
        <property type="gene ID" value="B7C42_05452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="43"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="280" mass="29861" checksum="BA39A8950C1B6030" modified="2017-10-25" version="1">MSEAPAEPLNAPAELPPLRHAPHGAARIATLGSRIATFAIVELQKLRHDRTELVTRAVQPALWMLIFGTTFARLHTIPTGDMPYLDFLAPGIIAQSALFIAIFYGIQLIWDRDAGILNKLMVTPTPRAALITGKCFAAGVRAIAQVLIIVVLALIMGVHMTMNPLKLLGALTAVVLGAAFFACLSMTIAGLVTQRDRLMGIGQAITMPLFFASNALYPLALMPGWLHAVSHVNPLSYEVDALRGLLVGGTADLWTDFGVLVLAALLGIACASALLGRLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1K0</accession>
    <name>A0A231H1K0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42719">
        <property type="protein sequence ID" value="OXR42719"/>
        <property type="gene ID" value="B7C42_05056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="34440" checksum="DA8F436F76EAED1D" modified="2017-10-25" version="1">MRASVELPSDWQARVRGALADSPRPELADGALRLLGAGLDSVALQLDSARDAYVLRLPQDPHGAEGIAREAGLLPELAPLLPVPIPQFLFTAPNPLGPGKFCVYPLVPGESLDEADWAERGLLRPDTARTIAQLIERIHSFPVDRARDFGVEVTDMRGDFAADLKSVRAEVLPLLDAAEAAALSGAWQRYLDDDANFDFEPTLIHADMSLDHLLISDGTISGLIDFGDVEIGDPDYDLCYLYPEAGRDFVRQIQRYRARDLGPVVENKLRFWACADPALDVLDAVEQGRTDFREQRLTVLRQALRGYLPNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Q1</accession>
    <name>A0A231H1Q1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 107B1</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42774">
        <property type="protein sequence ID" value="OXR42774"/>
        <property type="gene ID" value="B7C42_05112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="425" mass="46485" checksum="3F3D6D266DDB76C6" modified="2017-10-25" version="1">MNAPQPGLTAGGCPVSPTDPVPLSGPRFHTDPHELYREMRRAHGPVVSVVLPGGIPAWLVIGYREVHQVTSDGELFPRDVACWNQWPNIPEDWPLLPMVGRPMPSIYFTAGAEHMRHLAMVEPALEQVDPFGLRRACEDLADRLIDHFCGRGHADLIAEYAEPLPVLALAWVIGFPDEQGADLAWTMKTLADGGAEAQAAYGRFADHMQRLVAMKKSRPGNDLTSRMLRSPQRFSDEEYALDLMAVTAAGQLPTSDWLGNSVRLMLTDDRFAAALGGGRHSIGQAMNEVLWEDTPTQILAGRWASRDTRLADKTIRRGDMLLLGLAGANADPHVRQDLSDSLAPAHSGNSAHFAFSYGEYRCPFPAQQIAEIIARTGIEVLLDRLPDLDLAVAATELTRRPSPFLRGMTSLPVTFTPVRTVGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1X1</accession>
    <name>A0A231H1X1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_05183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42845">
        <property type="protein sequence ID" value="OXR42845"/>
        <property type="gene ID" value="B7C42_05183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="429" mass="46007" checksum="C05CCD96A0764A6D" modified="2017-10-25" version="1">MTADPTGREAVAAVWRIESARIVGALARYTGDFALAEDLAQEALAEALVTWPREGTPHNPAGWLLTVGRRRAIDTFRRRSALDDRYAALARDLGEGGVLTGGPGADPTRSGAEPLWDPDRIDDDVLALIFTACHPVLSREARVALTLRVVGGLTSDEIARAFLVPAATVQARITRAKKTLAAEHIPFEVPEAGARAARLSSVLSVIYLIFTEGSSASSGSELIRFDLAGEAQRLARVLSHLVPDEPEVYGLLALLELTAARFPARTGADGEPVLLEHQDRRRWDRAAIRRGRAALARAGQAGRGLGYYGVQAAIAECHAVADSVADTDWDRVVSLYEALGRLAPSPVVELNRAVAVAMAKGPDAGLAIVDGLRAEGALPNSQQLPTVRGELLARLGRTGEAREEWELAVRLCGNDRERAVLHRKLDHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2L6</accession>
    <name>A0A231H2L6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gcvP</name>
        <name evidence="9" type="ORF">B7C42_04970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43084">
        <property type="protein sequence ID" value="OXR43084"/>
        <property type="gene ID" value="B7C42_04970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="937" mass="100010" checksum="40FD3F58905912FA" modified="2017-10-25" version="1">MTRSFADRHIGPDTNELDRILDTVGVGSMGELAARAVPASILDAVGETGLDVLPPAVSEHDALTELAALAHSNTVATSMIGLGYYDTLTPPVLVRNLLENPAWYTAYTPYQPEISQGRLEALLNFQTMVSDLTGMEVANASMLDEATAAAEAMTLLQRANRKSTSQRLLVDTDLFPQTRTVLTTRAEPLGITLVEADLSSGELPEGDFFGVVLQTPGASGRIADPAAVIAAAHDRGALVAVGADLLALTLITPPGDLGADVCFGTTQRFGVPLGFGGPHAGYLAVRTAHARQLPGRLVGVSVDADGDRAYRLALQTREQHIRREKATSNICTAQVLLAIVAAMYASYHGADGLRAIARRVHGHAERLAGGLGDAVVHERFFDTVLVSVPGGAEAVVAKAKGRGINLRLVDADHVSVACDEATTEAQVAIVLECFGAGGMPETAALPSIETRTSAYLTHPAFTRYHTETAMLRYLRQLSDKDIALDRSMIPLGSCTMKLNATAEMEPITWPGFARLHPYAPVEDTPGMLRVIEDLEHWLAAVTGYDRVSLQPNAGSQGEYVGLLAIRRYHLDRGDTHRDTCLIPSSAHGTNAASAAMAGLRVEVVKCRDNGDVDLDDLRAKIADHADRLACIMITYPSTHGVYEHEVAELCALVHDAGGQVYVDGANLNALVGLARPGRFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVRDHLAPYLPGDPLQPDSHAVSAARYGSASILPITWAYIRMMGADGLRRATLTAIASANYLARRLDPHFPVLYTGENGMVAHECILDLREITKRTGVTVDDVAKRLADYGFHAPTMSFPVAGTLMVEPTESENLEELDAFADAMIAIKGEIDEVAAGTWPVEQSPLRGAPHTAAALVGDWNYPYSRETAVYPLGVHSRRAKVWPAVRRIDGAFGDRNLVCSCPPLEAYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3E1</accession>
    <name>A0A231H3E1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase MhqP</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mhqP_5</name>
        <name evidence="6" type="ORF">B7C42_04761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43338">
        <property type="protein sequence ID" value="OXR43338"/>
        <property type="gene ID" value="B7C42_04761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="17660" checksum="00A8E0369D42778A" modified="2017-10-25" version="1">MTAIDAELALLRVCLGLTMAAHGYAKLVRGGRIPGTARWFDSIGMRPGKVQAWLAAGTELGAGVLLALGLLTPFAAAAFVSLMAVAAWTVHRGHGFFITGNGWEYNLILAVGAVSVAIGGAGRFSLDWAILGHNVFDGWGGFALSVVLGLAAAAALLGACYRPVREPEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3K6</accession>
    <name>A0A231H3K6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative CoA-transferase</fullName>
            <ecNumber evidence="1">2.8.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43346">
        <property type="protein sequence ID" value="OXR43346"/>
        <property type="gene ID" value="B7C42_04769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="493" mass="51549" checksum="3B0D1758AFD1CE6F" modified="2017-10-25" version="1">MSQSDIEQTRPVRHCEAVTAESADVMPLSGVAIEARGEGVAAEHARRLLQELGARPENDRGQRRTVSVDARSAVRAWADSGAMALTGRAGGPPLVSPGAPAAATGAALALLAALRPPDESSAPPWPGIEVLGERAALFGRGRNAPWSVGGAFRMFPTTHGYLGISLPRQDDFTLLPALVEGEVGGDPWQAVAEWARTCSAEDAAARAQLLGIAAAAVPDTPGMPQDAQFRHRNGRGIVVRPGGVRQPRRAEPVVVDLTALWAGPLCAHLLGRTGAHIVKVESTRRPDGARSGSRDFFDLMHAEHACVAVDLTTAEGVETLQRLIDVADLVLEASRPRALRQLGIDAESAVAGGTNWLSITAYGRTGPWSDRVGFGDDVAAAAGAVVFDGCEVLPCGDALADPVAGVHAAVAAAAVLSSDRAFLVDLSMRDVLAATLRDRVEPHEVVHGPDDLWHVRTADAEFPVAAPRARHAPTVAAALGADTQETLSRWLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3K7</accession>
    <name>A0A231H3K7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779329.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43424">
        <property type="protein sequence ID" value="OXR43424"/>
        <property type="gene ID" value="B7C42_04291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025568">
        <property type="entry name" value="DUF4334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025951">
        <property type="entry name" value="GXWXG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14232">
        <property type="entry name" value="DUF4334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14231">
        <property type="entry name" value="GXWXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXWXG" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4334" evidence="2">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="155" mass="17403" checksum="E4768AC8C9BCE163" modified="2017-10-25" version="1">MTGTTERWRELAAQSSGVSTDELDRLWAELAVVRAEDILGEWKGAAFRTGHPLCRALDKSGWYGKTFHSTMDAKPLICRAEDGTLYSDVELGGGEATLWNIEFRGEVTATMVYDGRAVFDHFKRLDENTLMGIMNGRPELVLAGGEYFYFLLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3V3</accession>
    <name>A0A231H3V3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43416">
        <property type="protein sequence ID" value="OXR43416"/>
        <property type="gene ID" value="B7C42_04283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="PTHR38567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="25347" checksum="DB8028A8B64E5998" modified="2017-10-25" version="1">MIPRGRRSEIRSPTESFGVTLYTMEEPRHRIRALHTASTVTVYQAYSPAIGRPAIRDGAFPAAWNRDRMTWIKPSFLWMMYRCGWGTKPDQETILAVEISRSGFDWALRHACLSTYKPGLHPDRSTWQRRLKRAPARVQWDPERDLSLRPLPYRALQLGLCGEAVRRYADEWTVAISDMTPLAHEIHELVRDGDLDSAARLLPDERPYPAADELLAHLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Y1</accession>
    <name>A0A231H3Y1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor SigF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigF_4</name>
        <name evidence="9" type="ORF">B7C42_04445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43577">
        <property type="protein sequence ID" value="OXR43577"/>
        <property type="gene ID" value="B7C42_04445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="253"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="33816" checksum="DDD71DD0B8A95625" modified="2017-10-25" version="1">MADENNVFEAEDAENTAGTAASGSPDDTGTEDGEGRADGEATPDDEEDGDEVAEVTGSVSGYDDVNLLFQALSEAGDDRRAELRDELINRCIPLADHIARKFSGRGEPFDDLTQVARVGLVHAVDRFDVSRGSNFLSFAVPTIMGEVRRYFRDNTWAMRVPRRVKETHLRIGSAIDTLSQSLGRSPTAKEIAAELDIHPDEVTQAVIAGNAYQPSSIDAVSVGRDTEASLLDTLGEEESQFDRVEEYVAIRPLLAGLPERERRILTMRFFESMTQTQIAQRMGISQMHVSRILAKTLARLREQSARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H452</accession>
    <name>A0A231H452_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.5.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msuE</name>
        <name evidence="2" type="ORF">B7C42_04476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.38" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778921.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43608">
        <property type="protein sequence ID" value="OXR43608"/>
        <property type="gene ID" value="B7C42_04476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052873">
        <property type="term" value="F:FMN reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023932">
        <property type="entry name" value="Uncharacterised_CE1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04037">
        <property type="entry name" value="LLM_duo_CE1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="23378" checksum="DCD9FA5965AD76D7" modified="2017-10-25" version="1">MSHTVVVLTAGLSQPSSTRLLADQLADAVASAVGARGEAVDIEVIELRDLASDLAATMVSGGLPTPAVAAAREKVSAADGLIAVTPVFAASYSGLFKMFIDVLDTEALNAMPVLVAATAGTARHALVLEHAMRPLFTYLRAVVVPTGVFAATEDFGSAGLGERIHRAAAEFATLVVAVPTGVDGFLPEPTRARQSGNHVGEVTPFAKLLAGHTGHTERPHRPAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H476</accession>
    <name>A0A231H476_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779145.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43592">
        <property type="protein sequence ID" value="OXR43592"/>
        <property type="gene ID" value="B7C42_04460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="25855" checksum="8B70631BCBA92E19" modified="2017-10-25" version="1">MQTRTDEIADRIYRISTFVPEVGPTGFSFNQFLVVDEEPLLFHCGMRALFPLVSEQINAIVPLERLRWITFGHVEADECGAMNLFLAAAPHAQVAHGILGCQVSLDDLADRPPRPLADGEVIELGERRVRHIDTPHAPHNWESRVLYEETTGVLFCGDLMTQVGDGPALTESDVVGPAVFAEDVFRATSLGPAVPAALYGLAELNPATLAVMHGSSFAGDGAAALRALAADYERRLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4M1</accession>
    <name>A0A231H4M1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781084.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43893">
        <property type="protein sequence ID" value="OXR43893"/>
        <property type="gene ID" value="B7C42_04132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="16469" checksum="3DA5EC29108CE7C0" modified="2017-10-25" version="1">MDHAAMGELVMAGFQKLGFIQFAGVEGVEYLPGRNVVSMAPKPEHLNHNGDVHAAILFGLAETAAMGASISGIVDLMGETFIVARDGRIEYLARANGEAGPFRATSEMTAAELEQARADIAAQQPVELAMPVDITDSTGKSVAAATFTAVIRPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4M9</accession>
    <name>A0A231H4M9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781179.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43797">
        <property type="protein sequence ID" value="OXR43797"/>
        <property type="gene ID" value="B7C42_04032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011238950" evidence="1">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13202" checksum="76AB0404C21A0C2A" modified="2017-10-25" version="1">MRKALFGLALLTTLAGSVAAATQAAAAAPVVQPDQQRAGVILTHDETAALGDGPIPALVTMVVPESRIGAGLKPDTQLYHDQNGNVHASLRQVIEEAASHPDGSVVVMANVPGSHGTRLLDVFQQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4V8</accession>
    <name>A0A231H4V8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_3</name>
        <name evidence="2" type="ORF">B7C42_04133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43894">
        <property type="protein sequence ID" value="OXR43894"/>
        <property type="gene ID" value="B7C42_04133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="35496" checksum="50CC874A7F6F59C6" modified="2017-10-25" version="1">MTIEQTQLGKTGPKVGRIGLGAMGMSGAYGASDEAESIATIHAALDSGATLVDTGDFYGAGHNEMLIHRALAERPREDYQLSVKFGALRGPDGSFGGVDTRPEAMRNFLHYSLQRLGVDYVDIYRPARLDPAVPIEDTVGAIAEMVQAGYVRHIGLSEVGAQTLRRAAAVAPIVDLQIEYALITRGIEREILPTARELGIGITAYGVLSRGLLSDSLRANQTFAPDDFRAHSPRFQGENLTANLRLVSALAQIGGRHGVSVAQLAIAWVLTRGADIVPLIGARRVDRWSEAVAALDVRLSESELAAIEAAAPAEAVAGDRYAAPQMAMLDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H508</accession>
    <name>A0A231H508_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44023">
        <property type="protein sequence ID" value="OXR44023"/>
        <property type="gene ID" value="B7C42_03579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="32803" checksum="D0B3269101F28486" modified="2017-10-25" version="1">MNDYLSLLPSTLQWISRQLDSVSPIPWPLWIGGLFPVYVAVVSVLLWFLRGSVWPVQCAYPRTSKGRPCRNWVPGEWMRCRHHNRRVRYRYGHEVVKLQRWQTLTRGNKIVDRPEVGVGALRLRPANATLLYERGYARPPLAVVRLLPDKLRAGLRRLGEARWSKPAQPEEAARPDHQSYELIATERRTDIAKGLNQVVRATQFATVAFCVAIVFTIVATVLRDTAQTVLQYVATLGFVLAWAATSAGVYGRSETWLKGACLKSLKWWAGIFVPVGLLNLAFTVMNKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5I4</accession>
    <name>A0A231H5I4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44149">
        <property type="protein sequence ID" value="OXR44149"/>
        <property type="gene ID" value="B7C42_03708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="23700" checksum="E9FA9183649CD004" modified="2017-10-25" version="1">MGRVNRAAGVLAGVVVGVSACGHHDDSLPALPATATVPPITAPAVTDSDALRARLLAPADLPPGFTQLEDAAPGNGQTPPDRSRTDPAECAKVLAPVGDLYSGPSARGAVHYSSPNFASIDIDIASYADGNAAQAFAAAQKLLRDCRSYSGTDADGTSVDYRLGGLDQPKAGSASASFQIRTTSGGMSLYSAATIAVVGSSVVQIAETSPAQVDPASLQDLTAKQVRRLEGTAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5U0</accession>
    <name>A0A231H5U0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nadC</name>
        <name evidence="12" type="ORF">B7C42_03750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44190">
        <property type="protein sequence ID" value="OXR44190"/>
        <property type="gene ID" value="B7C42_03750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="118"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR44190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="30225" checksum="ECDA3D4059B98E07" modified="2017-10-25" version="1">MALDPQLDPGELRTLIRTALDEDLRYGPDITSAATVPAEATVKAAMVSRQPGTVAGIDVGLLVLDEVIGAGNYEVTDRVADGTRVGPGDAVLTVVAPTRQLLTAERTMLNLVTHMSGIATATAAWVDAVEGTNCRVRDSRKTLPGLRALQKYSVRVGGGVNHRMGLGDAALIKDNHVVAAGSVIAALRAVRELDPDIECEVEVDSLDQLDAVLAEDVELVLLDNFPLWATQAAVQRRNSRSPRTKLESSGGLSLEAAADYARTGVDYLAVGALTHSVRVLDLGLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H600</accession>
    <name>A0A231H600_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">murE</name>
        <name evidence="12" type="ORF">B7C42_03684</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44126">
        <property type="protein sequence ID" value="OXR44126"/>
        <property type="gene ID" value="B7C42_03684"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="127"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="381"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="459"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="459"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="129"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR44126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="551" mass="56793" checksum="9279F3DFDF58DC7D" modified="2017-10-25" version="1">MQPSPQVLRPAVALPTPVQAVAELTGARLNSGDPAGIEITGIEQRSNAVQPGDLFAGLAGAKAHGARFAADAVARGAVAVFTDAAGAALIGELDVPVLVHDDPRAVLGELSAAIYGHPSRQLQVIGITGTSGKTTTSYLVEAGLTAGGLSTALIGTIETRIARRVEANPGEGTAGTSGAVEYRRVPSALTTPEAPQLHAMFALMVEQGVQAVVMEVSSHALALGRVDGVHFAVGAFTNLSQDHLDFHADFEDYFAAKRRLFVPDPGSPQRQVAADTCVICVDDAWGRRLAREASGRARVVTVATADCPTGETEPEWTVTGAAALADGGQQFTAVGPAGEIAARLRLPGRYNIANGLLAIAVCAEAGVDAAVAAAALGEVDVPGRMQRVNAGQDFLALVDYAHKPAAVESVIATLRRHLRDTGGRLAVVVGAGGDRDAGKRPLMGATAARGADLLVITDDNPRTEDPGEIRAAIRAGALGLAEAERGEVREIGDRAAAIAAAVDWARPGDVVLVAGKGHETGQEIAGVKYPFDDRQVLGQALERKMKDLTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H648</accession>
    <name>A0A231H648_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative conjugal transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44359">
        <property type="protein sequence ID" value="OXR44359"/>
        <property type="gene ID" value="B7C42_03147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="62"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="41891" checksum="6326CE6A4DD11D36" modified="2017-10-25" version="1">MSGVVSAELLDRVRERLAAQPGEHDPARLAAAIRAEAGRVLGDTDLLRALRLLQTEMTGAGALEPLLHDARVSDVLVTAPDAVWIDRGSGLERTSIRFPDEAAVRRLAQRLALAAGRRLDDAQPWVDGRLPEYERAPGESFGVRLHAVLAPIAQGGTCISLRVLRPVGHSLRGLTASGTLTPESELLLEKIIRARLAFLVVGGTGAGKTTLLSALLAHVDPTERIVCVEDAAELSPPHPHVVRLVARIANVEGAGAITVRDLVRQALRMRPDRIVIGEVRGAEVVDLLTALNTGHDGGAGTVHANSPREVPARLEALAALGGMGRAGLHSQLAAAVQVVLAMRRRPDGGRVLQEIGLVTRDGEAGVRIETAWSADAVAAPANTALRRSLDERLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D8</accession>
    <name>A0A231H6D8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44415">
        <property type="protein sequence ID" value="OXR44415"/>
        <property type="gene ID" value="B7C42_03204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="3">
        <location>
            <begin position="169"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="33211" checksum="57A25DC018A37108" modified="2017-10-25" version="1">MTSDFSRPDEADSSRPAAPAASGTSAVSGSDPAPARLTVGIVSAGRVGSALGVALERAGHVVFGVSAISDASRHRARTRLPEAQILPVEEIAARSELLILAVPDSELPGLVAGLAAARVVRPGTIVAHTSGANGVAVLSPLTGVRPLAIHPAMTFTGHDEDTARLANACFGITAADEIGYAIAQSLVIEMGGEPVRVPEENRALYHAALAHGSNHLVTLIVDAVAALRAALDGPGLLGQQVVDEQPNGLAERVLAPLASAALDNALRRGLPALTGPVARGDALAVSAHLEALAAADPELAEGYRAMSLRTAQLARTSPDLIGLLEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6J1</accession>
    <name>A0A231H6J1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folB</name>
        <name evidence="3" type="ORF">B7C42_03199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063006869.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44410">
        <property type="protein sequence ID" value="OXR44410"/>
        <property type="gene ID" value="B7C42_03199"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="130" mass="14263" checksum="372363CC03D93337" modified="2017-10-25" version="1">MSTDRIELRGLRAYGHHGCFDFERRDGQEFLVDITLWLDFAKAAATDELSATVDYGELAQRAVAIVSGPPRNLIETVAAEIADDVMRDERVVAAEVVVHKPSAPIPHAFADVRVVATRRRDVPPTPEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6K6</accession>
    <name>A0A231H6K6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44554">
        <property type="protein sequence ID" value="OXR44554"/>
        <property type="gene ID" value="B7C42_03343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="56" mass="5957" checksum="B997D14845042A13" modified="2017-10-25" version="1">MMAAKSANDIADDDLEPLADETARQAQRVVAAYATDADECRMLLSMLGIGPSARSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6S9</accession>
    <name>A0A231H6S9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulatory protein TcrX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tcrX_1</name>
        <name evidence="6" type="ORF">B7C42_03349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44559">
        <property type="protein sequence ID" value="OXR44559"/>
        <property type="gene ID" value="B7C42_03349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="26001" checksum="AA61FA38198358DD" modified="2017-10-25" version="1">MLVVDDEPMIVELLSVSLRYQGFEVATAANGAEGLDRAKQFRPDALIVDVMMPGMDGFGLLRRLRADGIDAPVLFLTARDEVEDKITGLTLGADDYVTKPFSLEEVVARLRVILRRSGHVVEETKSSRIRFEDIELDDDTHEVWKAGEPVALSPTEFTLLRYFMVNAGTVLSKPRILDHVWRYDFGGEVGVVETYVSYLRKKVDTGPDRLIHTLRGVGYVMRAPSRSRSSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6W4</accession>
    <name>A0A231H6W4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_7</name>
        <name evidence="5" type="ORF">B7C42_02717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44763">
        <property type="protein sequence ID" value="OXR44763"/>
        <property type="gene ID" value="B7C42_02717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21189" checksum="2F4B9FA981556810" modified="2017-10-25" version="1">MSGQPRARRDAQRNRQLLLDAALTAFTGEEGTVSLESIAKSAGVGIGTLYRHFPSREALIEAVYRSELEQLCDQAAILLGHHTPEVALRIWLGRYADFVATKRGMAEALREVIASGAVTSAQTRERLSAAIGSVLDAGIEDGTLRDDVRPEDVTAAMAGATLAGIDRGQIDRLLDLLLDGLRSSPARPGRATIVTERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Y8</accession>
    <name>A0A231H6Y8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-[acyl-carrier-protein] desaturase DesA1</fullName>
            <ecNumber evidence="8">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">desA1_2</name>
        <name evidence="8" type="ORF">B7C42_03409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497861.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44619">
        <property type="protein sequence ID" value="OXR44619"/>
        <property type="gene ID" value="B7C42_03409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="36529" checksum="6F5F1697C24AA6B0" modified="2017-10-25" version="1">MARDLTQLELLTELEPVAEENVNRHLSMAKEWHPHDYVPWDEGRNFAALGGVDWDPEQSKLSEVAKAAMITNLLTEDNLPSYHREIAENFSQDGAWGTWVGRWTAEENRHGIVMRDYLVVTRGVDPVALEQARMVHMTNGFASPAEADAGFLHSVAYVTFQELATRVSHRNTGKVCDDAIADRMLQRVAADENLHMIFYRNMCGAALDLAPDQALDAITLILENFQMPGAGMPNFRRNGVLMAKHGIYDLRQHLEDVVQPVLKKWQIFERDDFTARGEQTRERLGLFLDKLGKDVLKFEEQRDRMLAREAAKRERDLTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Z7</accession>
    <name>A0A231H6Z7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG2_3</name>
        <name evidence="1" type="ORF">B7C42_03285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775873.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44496">
        <property type="protein sequence ID" value="OXR44496"/>
        <property type="gene ID" value="B7C42_03285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="27994" checksum="D0A65D377F561CB9" modified="2017-10-25" version="1">MPDLSVPPQPVSGHGLLAGRVAVITAAAGTGIGSATARRMLDEGADVVVSDWHERRLKQTEEELAAEFPQRKVASVVCDVTSTEQVDELIRAAAQRLGRIDIMVNNAGLGGETPVVDMTDEQWDRVLDITLNGTFRCTRAALNYFRTAGHGGVIVNNASVLGWRAQHGQAHYAAAKAGVMALTRCSAVEAAELGVRINAVAPSIARHPFLDKVSSTELLDRLAAGEAFGRAAEPWEVAATIAMLASDYTSYMTGEVVSVSSQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H713</accession>
    <name>A0A231H713_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44635">
        <property type="protein sequence ID" value="OXR44635"/>
        <property type="gene ID" value="B7C42_03429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="62" mass="7387" checksum="F97C9D0E5136ABE9" modified="2017-10-25" version="1">MIGMGDSDEKWYYCLKHHRAEQGKRCWFADRMGPYPDRATAERALEIVRERNAREDARDGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7D7</accession>
    <name>A0A231H7D7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal large subunit pseudouridine synthase A</fullName>
            <ecNumber evidence="2">5.4.99.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rluA_2</name>
        <name evidence="2" type="ORF">B7C42_03496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.28" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44702">
        <property type="protein sequence ID" value="OXR44702"/>
        <property type="gene ID" value="B7C42_03496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="27789" checksum="088B917FBE5E5203" modified="2017-10-25" version="1">METGWQQLAQQYLVDEDEAIIALNKPAGIAVTGERHDTDLVELAAAEGITLYPVHRIDKVTSGLVLFAKDLAAHGGLTRQFTKRTADKRYLVVTAATDLPDTGVIDLPLSVGRKNRVRIAAPRDTIRREGQLWTVDQSDLLAGKNYPSRTEFTTVARTDRHTILLARPITGRRHQIRVHLAWIGYPIAGDPLFDKSGGYARTHLHSLSLRVEAPWRADSELALTATPGADFFSTGSAPILENPAGLLERIATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7K4</accession>
    <name>A0A231H7K4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-methylmercaptopropionyl-CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dmdB_1</name>
        <name evidence="3" type="ORF">B7C42_03532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.44" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776340.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44737">
        <property type="protein sequence ID" value="OXR44737"/>
        <property type="gene ID" value="B7C42_03532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="450"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="544" mass="58854" checksum="98512CEB8CA9D9C1" modified="2017-10-25" version="1">MLSTMQDDQLSLATLLRYASTFHGDATVSTWTGDGVRTMTYRELGAESARLANALRGLGIDVGDRVATFMWNNNEHMVAYAAVPAMGAVLHALNLRLFPEQVTYVANHAEDRVVIVDGSLLPMFAGYLPTLKTVRHVIVANGNAADLTAPEGVQVHSYAELLAGQPDTYDFPVVDERSAAGMCYTSGTTGDPKGVVYSHRSNVLHAMQVLTNASMGFTSDDTVLAIVPLFHANAWGLPYAAMLSGASVLMPDRFLQPAPLLEMMAAVQPTFAAAVPTIWGGVLAQLEAKPQDITHLREVVVGGSALPPSMMRAFQEKHGVRLLHAWGMTETSPLGSVAHPPKGVTGEDEWEYRYTQGRFPALVQARLVGDDGSVLPNDGEAVGELEVRGPWIAGAYYSPEGASVDPDKFDDGWLRTGDVGKITPNGYLTLVDRSKDVIKSGGEWISSVDLENAIMGHPAVAEASVIGVPDEKWDERPLVAIVLKEGSTAEPAELRDFLADKFAKWQLPEHWTFIDEVPKTSVGKFDKKRLRARYADGELSVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7N9</accession>
    <name>A0A231H7N9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enoyl-CoA hydratase echA17</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45033">
        <property type="protein sequence ID" value="OXR45033"/>
        <property type="gene ID" value="B7C42_02990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="26520" checksum="1329F004EEEBEAAF" modified="2017-10-25" version="1">MAEFVTVDRVEAGIAVLRFARPPLNLVDLQLALELAAAADALAADNEVRAVIVYGDERIFSAGDDVAELARWTPGQAGAVAADLQQALGCLARIPQPTIAAITGYAVGAGLELALGADRRLIGDNVKLGLPQIRAGLIPVAGIRRLGLLVGPGPAKDLVYTGRYVDAEEAAAIGLVDEVVAPDDVFGAALRWARQFTTGPARALAAAKRVFEAGPHGLDRARTEWAELFDTEDRSVGTRSYSASGPGAAEFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7V2</accession>
    <name>A0A231H7V2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">etfB</name>
        <name evidence="7" type="ORF">B7C42_02971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515697.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45014">
        <property type="protein sequence ID" value="OXR45014"/>
        <property type="gene ID" value="B7C42_02971"/>
    </dbReference>
    <dbReference type="GeneID" id="66722110"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="27567" checksum="35F31F29E550D9E9" modified="2017-10-25" version="1">MPNIVVLIKQVPDTWSERKLSDGDYTLDREAADAILDEINERAVEEALLIKEAQGGEVTVLAMGPERATEAIRKALSMGADKAIHVKDDAIHGSDAVQTAWVLAGALGQIEGIELVIAGNEATDGRAGAVPAIIAEYLGIPQLTHLRKLTVDGDKISGERETDEGVFKLEANLPAIVSVTEKINEPRFPSFKGIMAAKKKEVQTFTLADLGIDPSTVGVGNAGTAVSGVTPKPPRTAGEKVVDEGEGGNQVAQYLIGQKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Y5</accession>
    <name>A0A231H7Y5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44955">
        <property type="protein sequence ID" value="OXR44955"/>
        <property type="gene ID" value="B7C42_02912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7269" checksum="49226C930F8B97BD" modified="2017-10-25" version="1">MSKDLSGAKWFKSSFSGSTKDCVEVAFLDDGVGVRDSKNRTGAALFFTPAEWSAFTAGVRRGRFDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H898</accession>
    <name>A0A231H898_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative peptidase</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776760.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45243">
        <property type="protein sequence ID" value="OXR45243"/>
        <property type="gene ID" value="B7C42_02368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="216" mass="23331" checksum="A02881A41FB8D288" modified="2017-10-25" version="1">MRLFLSSYRFGAHYDRFAELVGGPGPIAVIPNACDAWPSAWSGAVTSDLVPLRRSGFRPEVVDLRDYLGRPAALEQALREYPALWVRGGNTFVLRAQFARSAADLVLRELLAEDALAYTGYSAGACLLTPDLHGLEDADDPAEVRAACGIDPRWDGLGVVDRAIVPHVDSPGTDPDGHGTRLAERLRAAGTPHWALTDDDAVVVDGERTEILTTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8A9</accession>
    <name>A0A231H8A9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45040">
        <property type="protein sequence ID" value="OXR45040"/>
        <property type="gene ID" value="B7C42_02997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="17373" checksum="8A2F7ACDC8B6250E" modified="2017-10-25" version="1">MSSEGTGDGFSGRAPRRLPDGVPRTEGTEPQLQYPNEAGYYYRVLVQPPKPVWVRLDAILIRDPGAPRHVNGAGLDMTGERPGTLTHWVPSFSGEWLGRVNFSVCYADGRAPLHLTDQLVPAYALRPRAAVDDPRRPPTGRPNTSSRSERRTGEADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8M0</accession>
    <name>A0A231H8M0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45076">
        <property type="protein sequence ID" value="OXR45076"/>
        <property type="gene ID" value="B7C42_03033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="32044" checksum="8E5E4150EF11333C" modified="2017-10-25" version="1">MRAIQFVPAAERLAGARIVETERPVPGPGHVLVRTELTGVSVGLVRMLRADAEANPGGEMVGNVVAVGPGLDESWIGTRVGGVVFASVYAEYVCATPAMVTEIPAGVPAADALAVVRGGLVAMGVVRAAKSVAGKSILITAAASGAGHLALQLARAAGATRVVAAVGSAGKFDFVRECGADAAVTYDRPWSETFDIVLDGVGGDLVQRGVDSLGPHGTLVAFSAGGGAVDTSTLLGELKTVTGFSMGLLSRTEPELIERYRAQLWKLLERNEVRPRVEVRDWTELDAVVDLIATRRSVGRMAISAGTGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8N3</accession>
    <name>A0A231H8N3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Antiseptic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">qacA_4</name>
        <name evidence="8" type="ORF">B7C42_02439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45314">
        <property type="protein sequence ID" value="OXR45314"/>
        <property type="gene ID" value="B7C42_02439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="53"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="546" mass="56164" checksum="DC2B2E553EA45DEC" modified="2017-10-25" version="1">MNLRRSSESPALAETAARENATGSPRAIGGSSAANREAPTADAAGAGRARWLALGALALAMLTIGLDTTVLVVALPTMAIDLHANTAALQWFTTAYTLALAAVMLPAGALGDRYGRKKFLLAALVVFGGASLWCALATSAGMLIVARAVLGIAAAAMMPLSMSVLPSLFPDQAERQRALTIWVSSTALGLPLGPIVGGWLLNHFWWGSVFLINVPLVVVGVIAVALLVPETRSDSAFRIDLPGVLLSAAGMLGFTYGFIRFGEQGWGDGAAWAAVVAGAVLLGGFVWWQRRIAHPLVDIALFTNRGFRWGTAYSVFVNFAMFGMFFTVPQYFQAVLGVDSLGSGLRLLPLIGGLVVGTRAVDKLLPKLGARIVLSGGFLILGAGLAMGAMTEVSSGYGYTAAWTTILGFAMGLVMPAAMGMAMGQLGAERAGSGSALLQALRQAGGTIGVAVLGTVLATQYRSDLGSYNHEPISDGVNAGVAVARATGNADMLAQVQSAFVSGMGAMLWLCAGVCAVAALLAAIRTRSGEPDPHSADDAGESVHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8W5</accession>
    <name>A0A231H8W5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776742.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45271">
        <property type="protein sequence ID" value="OXR45271"/>
        <property type="gene ID" value="B7C42_02396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="110" mass="11595" checksum="4338D170971A1485" modified="2017-10-25" version="1">MTAVADEEILRAAELDLAVDEFGDDDTKLASVTAAVEVEADHGPVIRVLKGSPTDEDLAALVTVFAAASANAGAPQDQGPVDNWGRPTMMHRGTSPFSPYAFPYLSHIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8W7</accession>
    <name>A0A231H8W7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase FadD15</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45137">
        <property type="protein sequence ID" value="OXR45137"/>
        <property type="gene ID" value="B7C42_03094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="597" mass="64597" checksum="CCCC0EA96EBE9D6E" modified="2017-10-25" version="1">MTDTYAPWTLPEAFQATARKDPDAVALRTLGGEVQIDWRTYLARVRAIAAGLAALEVRRGDTVALMLTNRPEFHLVDTAAYHLGAVPFSIYNTSSADQIAFLLNSAQPRVVVCEEQFYSVLEKAAQGTTVEHVICVDGSPGEASPLSELESSPLPGFDFDAAWQAVSADDVLTIIYTSGTTGDPKGVQITHANMLAELSATNWFMHAQDGDSVVSFLPSAHIADRYGCHYLNAYAGVQITTIADRTQLLPALVEVQPTLFGAVPQMWAKLRAGIEAGIEAESDEAVRTQIRGAIAFGEQYVRAKQTGQVTDEQERTYQTLDEKVFRPIRAKLGLGRARFVQTGAAPVPEDLIVFFNALGIPLVDVWGMSELSCFATMTPEGGLRLGTIGKAIPGVEITTATDGELLVRGPIAMKGYLGRPDLTAETIDAEGWLHTGDIGSIDEDGYVRLVDRKKELIINAYGKNMSPANIEKAIRAGSSLIGQAVAIGNDRKYNVALIVLDQDAAAQYAAARDIVADPAVLAADSRVREVVAAAVEAANATLNRTEQIKKFRILPTFWEPGSEVLTHTLKLRRRPIDELYAAEIDELYSDAVQLASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H921</accession>
    <name>A0A231H921_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">infA_1</name>
        <name evidence="2" type="synonym">infA</name>
        <name evidence="5" type="ORF">B7C42_02579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003886926.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A231H921"/>
    <dbReference type="EnsemblBacteria" id="OXR45454">
        <property type="protein sequence ID" value="OXR45454"/>
        <property type="gene ID" value="B7C42_02579"/>
    </dbReference>
    <dbReference type="GeneID" id="66836896"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="73" mass="8503" checksum="70CEADB89E985B48" modified="2017-10-25" version="1">MAKKDGAIEVEGRVIEPLPNAMFRIELENGHKVLAHISGKMRQHYIRILPEDRVVVELSPYDLSRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA37</accession>
    <name>A0A231HA37_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulatory protein EmbR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">embR_2</name>
        <name evidence="4" type="ORF">B7C42_01991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45699">
        <property type="protein sequence ID" value="OXR45699"/>
        <property type="gene ID" value="B7C42_01991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1090" mass="116977" checksum="3705CD0DF5EBC360" modified="2017-10-25" version="1">MVRIRVLGALTASDEHGELDLGGPRQRGVLARLLVARGEVVPVDRLIDDLWRGEPPPRALGSLQAYISNLRRLLEPERAPRAPATVLVSRAPGYALRLDTEAVDAWLFGAEWDLAARQTDPQRRRRALEQALARWQGPAYGAYAQEAWAAAEAARLEELRLSAREQLAAALLDQDEPALAAAEAEVLTREHPLREEAWRLTALARYRAGRQADALATLRQAREILADELGIDPGPALTRLEADILAQRIPVQEKVIAESLPPRDPATAATATVLFGRDAELAALHGAARGDGPRTATVAGEAGSGKTALLHRLRDDLRDGGHRVVIGRCPEDEAAPSAWPWVEVLRALAGEHDPRDLAPALAPLLTDGAGPERADRAHGRFLLHRAVIDYLTAVAHARPLAILLDDAHRCDAETAALLAAVATRAPVFTVIGYRPDEVPPALADALASSATTVGVRIRLRGLGTADSARLVGALLGRAPADPVVATLHDRTGGNPFYLIEIARLLQSEGELVAASEVPEGVRDVLRRRLSRLPETAVSVLRLAAVIGREFDLGVLARAAEVGEEEVLDAVEAGVVAGLLHEPASGRARFAHVLVRDTLLGDLSRIRRDRWHRRIGAAIEELDPADLTALAYHYGESVTPQTARRAADYAVAAAQRAERRFAHDVAAAGYERAARALERHPGDTVDERVALLCRAGRSHLVCGDGPAARAARDRAATLAEDADRPGLLVRAFTAWDAPTPWMNRRYGVVDHAVVARVETALRCPGLAPADRCRLSVALVEEIGGAELDRARRVAGEAEALARDLGDDTLLAPALQARSSLYDSPDRGALGAELIEIGRRNDHHAYLLLGHTVAVQAAAFAGDLEAARAHLEAATGPADRYQWRQAQAANAMARGLLALVGGDAGDAERRYLEAAELLSRTGIFNAGTLPLMALFTVRLYQGRAGELAETIEEFIRSAPADTADATVDFHALVLLAAGDRAAAARVRRRARPVPEDLFRSLFLTLRGMVIAALGTAEEAAAIYRDLLRYRDRLGGADTGSFTVGPVDLVLGDLAARYDDPDLAAEHHRAALRIAEGCANQGWIDAACARLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA96</accession>
    <name>A0A231HA96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063063049.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45657">
        <property type="protein sequence ID" value="OXR45657"/>
        <property type="gene ID" value="B7C42_01949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="9131" checksum="DF5426211C9C9A0D" modified="2017-10-25" version="1">MTRTITQAELRNGSAGIMDALEAGDDFVITRNGRPVGELRPVTTKRTVTAAVAKQRFARFAAYADSAAERAQVDAEFGEDRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB79</accession>
    <name>A0A231HB79_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043355.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46095">
        <property type="protein sequence ID" value="OXR46095"/>
        <property type="gene ID" value="B7C42_01059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="22194" checksum="6B6F1C2266E469CC" modified="2017-10-25" version="1">MTADAMPTGDRPSPGWPIPPPEGYVAADLDRLPDLPPHTELIDGSLVFVSPQKLFHMCVVDFLRGELKHRAPKHLVVLREMTVTLGSRQRPEPDVMVVDAVASTNLEETAYKPSDVTLVVEVVSPDSVERDRKRKPQLYAEAGIPHFWRVENADGRAVVYVYELDPATGKYTPTGIHHDRLQVTVPFDIDLDLTRATQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBW1</accession>
    <name>A0A231HBW1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043433.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46312">
        <property type="protein sequence ID" value="OXR46312"/>
        <property type="gene ID" value="B7C42_01278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18618" checksum="48F8DB2015BD98D6" modified="2017-10-25" version="1">MIVVMPVKLEGPLRDLNSWKPDGCSIVKALDIVGARSAMLILRESIYGTTRFDGFAARVGITDAAAAAALRKLTDAGLLRKQPYREEGKRTRNEYVLTEMGRDLLPAIFALWQWGDKYLQGGVPPLERVEDTTGEPVRVELRGAGGDEIGLEDIRIRVNEDWRRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC64</accession>
    <name>A0A231HC64_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46409">
        <property type="protein sequence ID" value="OXR46409"/>
        <property type="gene ID" value="B7C42_01375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011243734" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="40"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="45"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="370" mass="39667" checksum="0754B234F0D2EDA1" modified="2017-10-25" version="1">MMRKTRRDRALNTWRARAAKTVAIGAVALVAGSCGSVQNAVGGSTHITADFRNIAGVFEGNPITVLGLEVGKVDKIIPKGEFVEVHMTVNHDVEIPKNVTAAIVSPSIVTNRHIELTPRYTGGPKLPDNTHLTVQQTRTPVELDTMIKTIDQFTAALKPAPGQTQGPLSGTLLYDMVNGQGERIRDTLNALSGALKVGVDNKDAISTIIIKLNELTAMLADNDQSVRDFSNKVTQMSSLLAEQAPGLQATLDQLNDFLANTSGVFSQYQSQLSESLTGLTKVTDQLRQNAAGVVETVDVAPLLLQNLDRSMDRNRGFVRLHAVLGTALSGEVVSLFCERIQMKADGCRTGKIEDFGPDLGLSAALLGLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCA2</accession>
    <name>A0A231HCA2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0232 protein B7C42_01418</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0232 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781825.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46452">
        <property type="protein sequence ID" value="OXR46452"/>
        <property type="gene ID" value="B7C42_01418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00630">
        <property type="entry name" value="UPF0232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023007">
        <property type="entry name" value="UPF0232_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="19836" checksum="6B0174880051EDD2" modified="2017-10-25" version="1">MAAEPGREDGSPPSTGPEPELRGVDLARRALEEARAAARASGKAVGQGRASPRKGGVRALRRRSGWSGARPDDRDPQLLSALAGSLAKSRGWSGKVAEGMVFGRWSAVVGDDIAAHADPVSLTDGVLSIQAESTAWATQLRMLQSQILAKINAAVGQGVVTSLKISGPAAPSWRKGERHIKGRGPRDTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCA5</accession>
    <name>A0A231HCA5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85B</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpB_2</name>
        <name evidence="2" type="ORF">B7C42_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46574">
        <property type="protein sequence ID" value="OXR46574"/>
        <property type="gene ID" value="B7C42_01545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011301476" evidence="1">
        <location>
            <begin position="21"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="35936" checksum="01F6FF0A041D62E8" modified="2017-10-25" version="1">MALALLLPLGVSVFGNGASASAAFDPSGFDFWVDSPVMGAVKSRVFRAKDGNTDRVVYALDGLRAPQTLNGWEIETNVAQVLTDWNINVVMPVGGQSSFYADWNAPSSFFGAPPSNFGSVNTGSGATEAFLGGPGKDYRYDWETFLTGQLRNALRDRLGFRASRNGAFGLSMGGSAALTLAAYHPDQFSFAGSFSGYLNISAPGMREAIRMAMIDAGGYNVDSMAPPWGPQWLRMDPFVFAPRLIANNTRLWIAAGSGVPSQEDLGLPLPAAADHIMRGAPLEVLALANTRAFQVRMATLGASNAVYSFPNAGVHDWFNWQAEAYRMIPDLSANIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCE2</accession>
    <name>A0A231HCE2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase CsdA</fullName>
            <ecNumber evidence="2">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csdA</name>
        <name evidence="2" type="ORF">B7C42_01585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497057.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46614">
        <property type="protein sequence ID" value="OXR46614"/>
        <property type="gene ID" value="B7C42_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011340">
        <property type="entry name" value="Cys_dSase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01976">
        <property type="entry name" value="am_tr_V_VC1184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="401" mass="42396" checksum="344763A3CC6EB3AE" modified="2017-10-25" version="1">MTYDVARVRGLIPSLGDGWIHLDPQAGMLVPDSVSRAVSTGFRTSAFSHTNRHAAARRSGAILDAAREAVADLVGGDPAGVVLGPDRAVLLAWLAESLSSRLGLGTGIVLSRLDDEANVAPWLRIANRYGAHVRWAEVEIETCEMPAWQFEELIGPTARLVAVTAASPIVGSAPAVRVAADRVHEVGGLLVADCFGAAPYALIDIDELNADVVALSAPAWGGPQIGALVFRDPAFLDRIPSMSLNPYAKGAERLEVGGHQYALLAGLTTSIDYLAGLDEQATGSRRERLEVSITSLQDYHDQLFENLMEVLDAVPDLTVIGRASTRIPTVSFTIAGMQAEKISAELADHRIGTVSGAHGGSRLLDALGVNDEGGAVTLGLAPYTTKFEIEQLGRALNSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCJ0</accession>
    <name>A0A231HCJ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor ComR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">comR_2</name>
        <name evidence="5" type="ORF">B7C42_01456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46486">
        <property type="protein sequence ID" value="OXR46486"/>
        <property type="gene ID" value="B7C42_01456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22063" checksum="6067668176373A60" modified="2017-10-25" version="1">MGRPRQFDESALLDAATELFWSRGFEQTSVEDVSRASGIGNGSIYAAYRSKRGLFLAAFERYCEGRARLVREVVTSAPGSARAAVRALFDAIIDDCVAQPDRRGCLMLNSIAQLGSRLPEVIGIGNRTTSAMEQSVAERLRRAAEESGAELDAATLAAYSAAVVMTAQGLIQLSRLGTPLSRLREIAEVSSRNLPGAWDAPVAGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCU0</accession>
    <name>A0A231HCU0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Teichoic acid translocation permease protein TagG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tagG</name>
        <name evidence="7" type="ORF">B7C42_01583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46612">
        <property type="protein sequence ID" value="OXR46612"/>
        <property type="gene ID" value="B7C42_01583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="31097" checksum="E1D96BA585789CA3" modified="2017-10-25" version="1">MSDAQTFPRAFKDLREGFSQRELWLQLGWQDIKQRYRRSVIGPFWITIATGVQAAAMGVLYAAILNQDLWTYLPYVTVGLIVWNVINASILEGSDVFIANEGLIKQLPSALSVHVYRLVWRQFLFFAHNIVIYLVMLVAFGVWEHLDWSVLLAIPAIALVFLNSAWVSIVFGIFSTRYRDIAPILGSMTLMLFVLTPVMWTTKSLRDQGGAVSERAKLVELVPTYHYLEVVRAPLLGDPVPVRSWLVVGVITVVGWAVAILALKQYRSRVPYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCV3</accession>
    <name>A0A231HCV3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol oxidase</fullName>
            <ecNumber evidence="3">1.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">choA_1</name>
        <name evidence="3" type="ORF">B7C42_01791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46813">
        <property type="protein sequence ID" value="OXR46813"/>
        <property type="gene ID" value="B7C42_01791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127247" evidence="1">
        <location>
            <begin position="31"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="438"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="538" mass="57562" checksum="680090C98F5B7930" modified="2017-10-25" version="1">MRRRAFLQAAGAAVLLGATGALRETGTATADPAWDGMFRNWVSEIFVPLADPPEHTEAIVVGSGFGAAVAALRLAEAGIANTVLERGSRWPNDPWREIFTGDDLPDGRGFWHRTSFTGVTKVAMRFADFGGVLDVTEFDGIDVWRAAAVGGGSVIFSGCMIAPERRHFDEIFGGTVDYTELERTYYPRVRQMLRLSVMPADIYNSPPFAHSRMWDDQVRAAGYEPVPNESIFKWDTVRAELAGATRASATAARSNLGNSNGAKFDLNQNYLKYAHATGRSSVFPGHRVDSIGRDGDRYVLQVSKIDPTGKVLGIRTLTCDKLFLGAGSIGTTELLVRARATGTLPDLDEHVGDGWGTNGDVALARGESRLSGLGQGVPSASRIFDESGMPLTLESWYIPGIPVETGALASLGLVIDPTRTRITYDAARNAPALSWPRAAQDRIVAACRAVDQRIAERSGALFDYQALGYDANAPFTAHPLGGAVLGRATDNYGRVNGYPGLYVVDGAAIPGSTGAANPSLTITALAERNVEAIIRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCV6</accession>
    <name>A0A231HCV6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46679">
        <property type="protein sequence ID" value="OXR46679"/>
        <property type="gene ID" value="B7C42_01654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="30610" checksum="5C3A0B103D6344BC" modified="2017-10-25" version="1">MTSPTLVLNPDGSATWTGTIWFSNIQDIASTGVATLTLTPAGGWGNLPVLAQGAPGLPAVIDSITVNTLDPATVPTPTQSGQLTLVDPGGPGESAHYTLTLNLLKGAAGATGAQGHILGSSDFSNSPADGQVPVYNGTSGLVAWVSIHPVTPFYVLPGTSFTALNESAAGARDIVGAITIPAQTYRYRPRVSGDLEVTGAAGMRIDAEVRMGTQATADATISSTGTLVGYGRGQESALAVHLGITPYFGGATAMSASDVSPPASVAAGTAMRFVLTAVRQYGSAAWTTSQQLGELRLTLEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD46</accession>
    <name>A0A231HD46_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46716">
        <property type="protein sequence ID" value="OXR46716"/>
        <property type="gene ID" value="B7C42_01692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009467">
        <property type="entry name" value="Glycolipid-bd_prot_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06475">
        <property type="entry name" value="Glycolipid_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="206" mass="22103" checksum="92520B1B7F383BC5" modified="2017-10-25" version="1">MSKPAQGNSETAQASEAAAPRWPAVLTWRAHDASRMESVRVVLTGNRIRASGRIIAGGCGEHPAFSASYDLVTDEVGRTKRLSLRSTVASGERHASIARDEENYWLVDAGGTHVRSMFGGALDVDVVLSPFFNTLPIRRFGLAHATEDVQVPVVYVRVPDLLVQEAILTYSSGADGIHVLSPVSSATVTVDDDGFVLDYPGLAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDH4</accession>
    <name>A0A231HDH4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46846">
        <property type="protein sequence ID" value="OXR46846"/>
        <property type="gene ID" value="B7C42_01824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="24700" checksum="B02DF95250B192DB" modified="2017-10-25" version="1">MTRADSIIPAESDISVDTRRLFELAEQATGFMPVEEGRALYDAARRYAGDGIIVEIGTYCGKSAIYLGAAARDTGATVYTIDHHHGSEEHQPGWEYHDTSLVDPETGRFDTVTTFRRTMVRAELTDTVIGVVGPSATVAKHWRSPIRLLFIDGGHTEAAAQRDYDGWAHWVAAGGVLAIHDVFPDPADGGQAPYHIYRKALDSGNFREVAAIGSLRLLERGTGCGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDK3</accession>
    <name>A0A231HDK3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RutC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46876">
        <property type="protein sequence ID" value="OXR46876"/>
        <property type="gene ID" value="B7C42_01855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="155" mass="15596" checksum="2C97C1FE4A7B10EE" modified="2017-10-25" version="1">MTAGTDWRANLERLGLALPPVAAPAGAYIPAVRSGSLVYTAGQLPFVDGALSATGKVGADVTVEDAARAAGLCALNALAAVHDLVGLDAVVRIVKVVGFVASAPGFTDQPLVINGASELLGEVFGAAGVHARSAVGVFELPKNTPVEVELIAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDM3</accession>
    <name>A0A231HDM3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative succinyl-CoA:3-ketoacid coenzyme A transferase subunit B</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">scoB_1</name>
        <name evidence="3" type="ORF">B7C42_00037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46922">
        <property type="protein sequence ID" value="OXR46922"/>
        <property type="gene ID" value="B7C42_00037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:3-oxoacid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="217" mass="22754" checksum="A1D169BC6F999C6F" modified="2017-10-25" version="1">MSWSREQMAARAAAEMIDGEYVNLGIGLPTLIPNHLPDGVKVVLHSENGILGTGPYPAEDEVDPDLINAGKETVTVNPGAAFFDSALSFGMIRGGHIDTAVLGGMQVSQHGDLANWMVPGKMVKGMGGAMDLVHGARRVIVVMEHTDRDGGAKIVEHCTLPLTGKAVVQRIITDLGVIDVRDGTLVLRELAPGVTVGEIAAATGAELIVDLEEPAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDR7</accession>
    <name>A0A231HDR7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative crotonobetaine/carnitine-CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">caiC_1</name>
        <name evidence="3" type="ORF">B7C42_00088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46972">
        <property type="protein sequence ID" value="OXR46972"/>
        <property type="gene ID" value="B7C42_00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="430"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="538" mass="59740" checksum="A8C42E194E00A615" modified="2017-10-25" version="1">MELGEDRSSRIVGDWLREEAALDPDRQFVQCASDWVTLAELDRRSDRVAAGLQSLGVEKGDRVAVNLSNRIEYIVLIYAIAKTGAIQVPLNTYLRGEFLRHQLIETTPKIYIGDSAALDMLSPVLPSLPEQPQLVLVGDTPATNALPSVLDYAQLEASSAQVVEPEITPADMCAIIYTSGTTGPSKGCAITHGYYCNLINVFVDYGWYQQGDVIFGANPLFHFSGQTWLVAAALAVRGSVIVEPAFSASRYMARIRETGATAALGMGAMGMAVLAQPPSDEDRNHKLRHITFMPSTAEFTAQFAERFGIEPFAEVFGQSECWPALLGDPRGERRPGSMGKMTSGLRVKIVDDNDIEVPIGTSGEIVVRPDEPFRLFSGYWNNDRGTVETFRNLWHHTGDKARVDEEGYFWFSDRKKDSLRRRGENVSSVELEQAIMAHPSIAQAAVHAVPSELSEDDIKVCLVLAPQCEIELPELFEFFRKSVPYYAIPRYVEFLEALPANVNGRVQKFKLRERGITETTFDFEKLGYVVARADRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEL9</accession>
    <name>A0A231HEL9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type-2 restriction enzyme NgoMIV</fullName>
            <ecNumber evidence="1">3.1.21.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ngoMIVR</name>
        <name evidence="1" type="ORF">B7C42_00544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.4" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781659.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="REBASE" id="234849">
        <property type="entry name" value="Nce30759ORF546P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47421">
        <property type="protein sequence ID" value="OXR47421"/>
        <property type="gene ID" value="B7C42_00544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10010">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015105">
        <property type="entry name" value="NgoMIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037083">
        <property type="entry name" value="NgoMIV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09015">
        <property type="entry name" value="NgoMIV_restric"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="28726" checksum="BA433FD563A1A784" modified="2017-10-25" version="1">MTTPFRTELLGWRPSKKNKLGWKWVPNSADTDNVTSLLMAAHILEQIRQPNPNPGSEPVTAPNNPGALLETLVLTDLASQLPDLDPRRQWDFDRGKSIVGYAQYQHLAGIEAAISKDPNLRVTLGTDYLIKPDVLVGIRGTPTSTPHPWLHAAIACKWTIRSDRVQNIRHENGNMIRHRRGRLPHLVTVTAEPLPTRLASIARGTGEVDATYHIAYEELAKAVAVHGSSEQHNAWEEVTKQGRLLDYKNLARSLVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HER2</accession>
    <name>A0A231HER2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47298">
        <property type="protein sequence ID" value="OXR47298"/>
        <property type="gene ID" value="B7C42_00420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="26888" checksum="225BF2E8D8E47B5E" modified="2017-10-25" version="1">MIADRGLIYNEPGRYLSLGSARDPERAVAGFIFSAPPTTFDRRDVGAQKRFIADHFAGVGWRAPQLLAALQGAGDLYFDSLSQIRLDRWADGRVALLGDAAWCAGPGGNGTSHALLGTYTLAGELAAANGDHRIGFARYERIMRPTVERSQKFATGAGRFLAPATRWQIRRRDLTYRVLSSAVMSGIFTRMSSRFREDREAGVLSTARGSSGLRAGQGTRPWRARPAPDSTSSSIVARASSSRPAAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFA5</accession>
    <name>A0A231HFA5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase EstB</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">estB_1</name>
        <name evidence="2" type="ORF">B7C42_00689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779768.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47564">
        <property type="protein sequence ID" value="OXR47564"/>
        <property type="gene ID" value="B7C42_00689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="44741" checksum="671015F81DA0071F" modified="2017-10-25" version="1">MSEIKIEIDAAEAGLDPDRLRRFDDYLDGLVEAGRMPGWVGIIARDGKIAHIGTGGHRDREAGLAMEADSLFRSWSLTKPFTSVAALALYEDGAFGLNDPVADYIPSLRDVRVYTRGGGANLESRPAREPIRIWHLLTHTAGFTYGFHHSHPVDELYVQRGFEWSAPPGIDLATAVDTWASLPLLFEPGTAWNYGVSTDVLGRLIEVVSGKSLDTVFAERITQPLGLHDTKFWIEPEETQRLAAIYMADPATGLAVRNDAMGGDPTQRPTWLSGSAGLLTTAADFHTFLQMLLAGGTWNGARVLSPATVRYMTTNQLPGGADLGSFGRPVLPALTTMAGLGFGFGFMTVLDPAASKVIANPGEFSWYSATSTYFFVDPVTRITALAFPQLFPSKALPLFSRLRQLVHAAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFL5</accession>
    <name>A0A231HFL5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47608">
        <property type="protein sequence ID" value="OXR47608"/>
        <property type="gene ID" value="B7C42_00733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="21010" checksum="1B09CB5068CC3148" modified="2017-10-25" version="1">MPVRCRVALIGMETRRIAVGDRAWTVRVGGPESRHTVLLLPDAGAPADVYDQVCERLHNSDLRTITVESIDGLDKAAVYAILDDLGVAWANLAGYGVGAELAWQLGARGFGRFVGLVVAGRPHPAVAVDGTAVDATCPAVELPTTVIATEDLPRTVADSCGRHVFGEFRVTQVDTADVPIKADHEFATEIVLRSGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFL6</accession>
    <name>A0A231HFL6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein Stp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">stp_4</name>
        <name evidence="7" type="ORF">B7C42_00898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782851.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47773">
        <property type="protein sequence ID" value="OXR47773"/>
        <property type="gene ID" value="B7C42_00898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="477" mass="48670" checksum="91159F36730F8CAE" modified="2017-10-25" version="1">MSTPTLLTHGTRPASTPPARATLLVLLAGIFMATLDFFIVNVAIPDTQADLHASSATMQWVVAGYGLAVAAGLITGGRLGDLYGRRRLYGLGMAVFTLASLACALAGDAAELVVARIAQGAGMALLMPQVLGIISVVFTGTRRVRAFAAYGLAMGLAAVFGQLIGGLLIQADLFGLGWRTIFWINVPVGALTLAVLARLVPESRGDGGTRLDRLGVGLIATALAAVVLPLIQGREQGWPLWTWLSLATAAVLIAAFVTAARRSAARGGEPLVNPALFAERSFAVGSTIALSYQMTMGSFFLFLALYLQQGRGLSALGSGLLFLALGGAYLLTSMLSQRAAARLGRQVVAAGAVLQAGGYLLLALTVHELGADGSVLDLLPGMIVAGAGMGLALVPMPGIVLAGVTPRHAAAAGGVLATAQQVGGAIGIAVVGIVFYDRLAAAGGFASAFVASLVPMALLCLLTAALVQLLPAPRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGG2</accession>
    <name>A0A231HGG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase PknD</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pknD_1</name>
        <name evidence="3" type="ORF">B7C42_00932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47807">
        <property type="protein sequence ID" value="OXR47807"/>
        <property type="gene ID" value="B7C42_00932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="851"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="933"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="142"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1228" mass="131310" checksum="F64E74E9F322F215" modified="2017-10-25" version="1">MGTTWARRLPVAIALIAVTGLLLWVWLASGWETIGKVAGLITAVIGVLTAVAARWPGQRTTVDPDAALEALAGAVREQWHAEERLRRLADPRPLQLRWGNCGRDGVMDYWEVIRGVEGCDNPIELGGRLDEIVEVFERIPSRRLVVLGEPGSGKSVLAMHFTLTAVRRRSRGDPVPVLMPVASWNPREASLSAWMETRLCVDYPLLGGRVASGATLAHDLIAGGRIWPVLDGLDEAPEQVRSEVITALNRTLTVGDRLLLTSRSAEYEAAVDAAGDVVTAAAVIELIPLGFEEIASYLRLTSAPRRGLNKWDPVLAHLHEHPCDRLASVLTTPLMTSLARAAYSDGRADPGELLDATAFDTREAVETHLLDQAVPAGYAGESSPAGRNGAAVADAERRLRLLAGDLDRCGDRELAWWKRHLAIPSPLFAAVSGVAVGMLVVAVTLAAAWPTHSFTSTRWGESVEWSVRLGSLAAVVIGFFTVADLDRETPTFRRQAGRFTMVMALGSIAALAVGGLTYRAWIDTSYRSDITDSAVDTAQYVAESFLLIALVVGFVRVPPTPSPTAVLRESPRIADTTAGRFRAWIGPIAGTAAVVGIVFGLVHAIGVSAAGVVVRHESVRDVVLDVPREWLTVGPIAGLCSALGVRLGRRILRPVFAAGAERATTGQPRILAAVTVTAAGVVAGAFLLPIVREMLGGGKAVWEPALRAAKDGIRLGIGPVVILAFLPWETRPMSLQLRLRGRLLRLLIVSAIAATVGATTLWFAADLPDAGQKARDCVLVGPPFGLAVGILAVALDRPVTLDRPMGPLASLRLDRRAAVMYSLAYAVAASAATWLHAAINSTAALDAQDIGVFAVAFFVISYFLTASGRHTITSVWLWLAGRMPLRDMEFYRTAHRRGVLRQVGSVYQFRHALLQDRLAAGARRPFRHSRARAALVLAAAAALALSSVAGLVHHAYEHRDRLARSNAAALPFDDVSLPLGVAVDHAGTMYVAGTRFGRSANHVDDTSALGRLWRWEQGAPRPSMLPLTNLGLTFALAVDRANNLYVADRDNRHVLVLGPRSTVPATLPFSELVAPIGLDVSESGDVYVSDNGTGVVWKLPAGSTTAIALPFPKLDHVTAVAIDSAGTVYATEAGRNRVLKLTIGSTVPTALPFGGLDKPTGIAVDSEDTLYVCDRNGQVMQLRAGSAAPEAVHMTGLRWPQSIAVDDAHNLYVTNPYDNRVLELPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGK3</accession>
    <name>A0A231HGK3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,5-dihydroxypyridine 5,6-dioxygenase</fullName>
            <ecNumber evidence="1">1.13.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nicX</name>
        <name evidence="1" type="ORF">B7C42_00950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.9" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779661.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47825">
        <property type="protein sequence ID" value="OXR47825"/>
        <property type="gene ID" value="B7C42_00950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047075">
        <property type="term" value="F:2,5-dihydroxypyridine 5,6-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="36936" checksum="CA416252C273E26D" modified="2017-10-25" version="1">MPKTLTENFVEQFRLCKVNAGETVAVIAELGQKTEYVESAVAAARQLGAGVLVLHASSLSNPMLPPYRPDGREVAPLLAAAGECDFVVDVTVGGLIHSDVRTRITGNGKRMLFVAEPNDVLERLMGDENLRRTVEAGGRKLRAGSTLHVTSAAGTDLTADISGTDLPITHQWGYVDEPGRWDHWPSGFVACFPNDRTAEGRIVLQPGDALIPWQRYVQDTVTIEVEKGYIKKISGAGTDAHVLTDYFEAWGDDEVWATSHMGWGVLPHARWSAFDVYDPRSLYGQELRSTAGNFMWSTGSNRFADRETPAHLDVPMRGCTVEIDGVAVVRDGALVEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSU4</accession>
    <name>A0A231GSU4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmuramoyl-L-alanine amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000085">
        <property type="protein sequence ID" value="OXR39693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39693">
        <property type="protein sequence ID" value="OXR39693"/>
        <property type="gene ID" value="B7C42_08239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="31494" checksum="150EDA240519E00B" modified="2017-10-25" version="1">MKITNNLAAPQRPTVRDMSQLQADVVILSPNDSGARNPGTCQLMVIHTNEGPATGSVAGLLQYLANPRVEASYTIVVGGDGTIGRSNDDNYIPWAAGSPANERGLHLCCLGYAADTRADWLARPKQLDAAARVLRDWHDRYGIPLVKLSGAQMRAGQRGVGGHADTVDAWHATDHHDPGAGFPYDVVIGKAIALGGGPAAPESQEDDMPSAKEIVDAFLAARPTQPDGSSDATVGELLTWTDKHAADLVDQAAGPKSKDQRDGLAPTGWPQLAGLSLVDAVATIGAKLGIQGFQDKSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSV7</accession>
    <name>A0A231GSV7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000117">
        <property type="protein sequence ID" value="OXR39635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39635">
        <property type="protein sequence ID" value="OXR39635"/>
        <property type="gene ID" value="B7C42_08298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18905" checksum="7FBFF9E7EB3E8F82" modified="2017-10-25" version="1">MADGATAPQGPLASSLTDANNGKLTVGFSDNIRVNADEFVYIERDCQAFKEEIQDLQQMAQTISRREHWGLGETTEGLESAKILVGWFRGKAKIVDATRDTSNNVYDILQQHYDIVDQIQQLHRTIAQKYVETDQEFAAEYNALMANTPASPIGKVQIQPGVVPQSPAVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSV8</accession>
    <name>A0A231GSV8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DarT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000095">
        <property type="protein sequence ID" value="OXR39668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39668">
        <property type="protein sequence ID" value="OXR39668"/>
        <property type="gene ID" value="B7C42_08264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029494">
        <property type="entry name" value="DarT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14487">
        <property type="entry name" value="DarT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DarT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="15450" checksum="777256108147335B" modified="2017-10-25" version="1">MLYAIHKGNVAGHGPDCSRIVYLSTTVGELRRRGLAVLGTDRHALMDYAHFTDDDAELTTYVDWPLMRRRIWRSEADDPDRGERRQAELLVHRHVPWDSIAFIAAKTAATVAEVQAMVESARVSTRLLVRPDWYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSZ6</accession>
    <name>A0A231GSZ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000074">
        <property type="protein sequence ID" value="OXR39747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39747">
        <property type="protein sequence ID" value="OXR39747"/>
        <property type="gene ID" value="B7C42_08186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="16828" checksum="83A91557AE435CBC" modified="2017-10-25" version="1">MFAARAAGIVARMSGCVICDKHNGAGPLVSPVIYRDDLVVITHRGAQGEWARPGYLFVEPRRHVATLDLLDDAETIAFAHAVRASIGALRRVLEPTHVFTFVAGLSAAGVHFHQHVFTRPADTASDVPWHNADTPDAPRIPASGLHALCTELAAALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT36</accession>
    <name>A0A231GT36_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000065">
        <property type="protein sequence ID" value="OXR39787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782117.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39787">
        <property type="protein sequence ID" value="OXR39787"/>
        <property type="gene ID" value="B7C42_08139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="23535" checksum="B62F9A5A53523992" modified="2017-10-25" version="1">MSGTAEPVRPPKTDAEWARDTSRRLDSVENPTSMRVGEWVFSTSADGSLIVSNVNGGSVVLARRPEGGENDPDAIQDDAVPAVSVVRNAAQTLPSGGAAVIFDGARFQSGGDWTGGKTTFDAINAPVSGIYQVSGSVHFRDGSGYWMVIVLVDDQPMLYGRISDNSGQNNIWLTSQVNGLLRVNAGQKIQLWAAAYSGQGIGSTTLTSSPVPTVFSMSLVQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT40</accession>
    <name>A0A231GT40_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000064">
        <property type="protein sequence ID" value="OXR39794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39794">
        <property type="protein sequence ID" value="OXR39794"/>
        <property type="gene ID" value="B7C42_08134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="594" mass="64581" checksum="0687B1D35749DEF9" modified="2017-10-25" version="1">MPDLPLRQGLGRVEIDAAVHIGESATQLLDGQPGIGIGGIAPGVIHLREQAVSAIGVLGRRDDECGAVPGSGPGEFGQALRSGDDVPVRRLRVLFRQSSRDGGGQGNRIRYISARHDQLPAKAAVLLAHLGRVQPSVVMRFGRTVGRIRLQSVGDVPCLRGVVATHVPVVREPSVRCAEPGGGMREDGTVAQVIDESPTIGAAAAGCRQRGPHPLDNRPGFRQRPQSILRRSELLRRPAADAVVVLGWYLLVGVTRGPDKVGHSAHVVAVEGRVARIYVDRSQRHACFVQIPEQGGAIGCSLAAVAVDDDRELTSASCGNALCPAGEFPVEIVDRHVVDICLHRVETANEQQGHTGCAGGFDEQAGALQPHPIRVFRIADDDCCRHIRHRFGNRAILPRPTGAGDMSGQFEQRPACRNEPQWSRLGRNTDALSARYRLLERDSAGHSAESAGTGPTGEIVGEHLLVRNVIHKFPDQDDFVESRLSRADLPQPIDPFRISLHRPRKTNRSHVVVQFTDSGQQLEIVLEILQRTQRRKRVRTTGLRCDKFPKLLCESSHFPTRHIVHHGAVGEPARRKRTLQCGDVLADAAPEFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT68</accession>
    <name>A0A231GT68_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative murein peptide carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ykfA_2</name>
        <name evidence="4" type="ORF">B7C42_08184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000074">
        <property type="protein sequence ID" value="OXR39745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39745">
        <property type="protein sequence ID" value="OXR39745"/>
        <property type="gene ID" value="B7C42_08184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66C" evidence="3">
        <location>
            <begin position="67"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="19866" checksum="DE480376E3E879D9" modified="2017-10-25" version="1">MVGFSDITYLHLAVWHHCQVPGIHGGLAGLHATDTVHQLLTSTEPYVLERNPSLQSAAVESAGRARGFVIGGALAAMAGMVGAGLPELSGAIEAQRHVGLGHIDRHLTQLIRSGAFDNAAGFALGRFHGFQDYTDRGWNLVDVLRDRLIPLGKPILGGLEFGHGPDPHAIPLGSVAELDTDNGTLTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTG0</accession>
    <name>A0A231GTG0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043543.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39917">
        <property type="protein sequence ID" value="OXR39917"/>
        <property type="gene ID" value="B7C42_08022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="532" mass="57101" checksum="E352AAA8E07C9CB5" modified="2017-10-25" version="1">MTDVWERAAQLPDRERAAFMAWARQALTRRAALTSCRHSADLAQRIDPAYEVTPAIQMMAEHIEKAMTTRGGRLLITCPPQEGKSTLVAVWTVLRQLQRNPDTRILIASYSEDLARQASQAARNLITSHGTGARDPLSGVELPDRLGLALAGDRFAAGNWQIKGHKGGVVAVGMGGTITGRPCDMLIIDDPLKGMAAADSPTERAKVIAGFQGDLSTRLAPGAPIILIQTRWHEADLAGFLLQQDADSDPDAREWVHINFPAVATAGVPDALGRAEGEPLESARGRTAEDWARIRRQVGERVWAALYLGSPYPIGGALFSQAWFNTYRLAAEPALYRRGVYVDPAETGKGDEAGIIAAGLAGDGTVVLTEDASGQLSSAEWPRRACLLALSTGATEVVFEAYSAPKTYEQLLRRAYTDLVLEAASNADAPGTVEGVRVPADRPFHIRPWRAAGNALVRSVGLRHATSVGRCRVVGFRLATMEARAIRWQETQHQPDRVAAATIAFDELASGGQAAASQKPGGWGQMPDGITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTN9</accession>
    <name>A0A231GTN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782342.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39915">
        <property type="protein sequence ID" value="OXR39915"/>
        <property type="gene ID" value="B7C42_08020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16389" checksum="903330BBE8A52BA6" modified="2017-10-25" version="1">MPNTTRIPLADVLAARALYVIALPLLAIGDVVVYHGSQPSEHGEEFVVIGATNGRLGLMHRRGGYSMSNVRRTSVTPTGDVADMCEHCGHPAEDEHCVRATCDCRHGAPMTFAEQFDAIATGTEQVIRANDGTPVSVMLSAAEYVRLLEQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTS0</accession>
    <name>A0A231GTS0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39978">
        <property type="protein sequence ID" value="OXR39978"/>
        <property type="gene ID" value="B7C42_07957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017518">
        <property type="entry name" value="CHP03084"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03084">
        <property type="entry name" value="TIGR03084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Wyosine_form" evidence="1">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="29715" checksum="D71F03AA7D2D847C" modified="2017-10-25" version="1">MTLDYPALLRDLEQETDRLIDCLSSASELAWETATPAEDWAIRDQVSHLAYFDDCAHLALTDADRFRTEAARLTSLGPDFPDRIAEAHRHLSVGELRSWFEESRSRLLTAFTTDDPRRRLPWFGPDMSVASSATARLMETWAHGQDIYDALGVDHPLSSGLRSIAHLGISTFAFAHRLNNLEVPTEPVRVELYAPDTDEVWTWGPADAADRVTGPAEDFVLVVTQRRHCDDTRLIIEGRIASRWMTIAQAYAGAPGTGRPSRTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU08</accession>
    <name>A0A231GU08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lutC_3</name>
        <name evidence="2" type="ORF">B7C42_07815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778484.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40107">
        <property type="protein sequence ID" value="OXR40107"/>
        <property type="gene ID" value="B7C42_07815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="106"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="22148" checksum="A7F46793EF15B31E" modified="2017-10-25" version="1">MSTRENMLRRIRAATADAPDVAIERHYHRHGNTDTGALVALLTERLRDYSADVHTATDDAVAALLRTLTDGVSCVVPAGFPVPWTPPGAVVDDPPLPTEALDAIPAVLTLCSAACAQTGTIALDGGPGHGRRALTLVPDHHICLVRVEDVVDGVPELLARLSPGRPATLISGPSATSDIELRRVSGVHGPRSLTVVLLDNHGTTLEPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUE6</accession>
    <name>A0A231GUE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinose metabolism transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araR</name>
        <name evidence="2" type="ORF">B7C42_07679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40254">
        <property type="protein sequence ID" value="OXR40254"/>
        <property type="gene ID" value="B7C42_07679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="28515" checksum="3369A28D3E0D56C7" modified="2017-10-25" version="1">MKPGEKLPSGPELAQRYGVSKVTAQQAVAELRTEGLVFSRAGSGVFVKERTSKPVGLRPHLERAFVEPKVTVDFAGFAAETLHGAISEPLDKIRDGRFRPESIDVRILVPDPGTPWALPSRASDLADMPAFRRRLQRIMERHAFGIHDEVLELKRIGLIESASVQIRVYPATPLFKLYVINGIDAFFGFYPIEEHQLPLDGEDTVMLDLMGKNATLFHLEADQAEQDSFQSQFIDQCQRWYESVWKIGRDLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUH0</accession>
    <name>A0A231GUH0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40267">
        <property type="protein sequence ID" value="OXR40267"/>
        <property type="gene ID" value="B7C42_07692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="89" mass="9951" checksum="138AA46C9B5DCDB1" modified="2017-10-25" version="1">MPVAPRTRIRLKSHAGLSGGDRIGYVAPPGHSAVVRTDFDHASGELVQVWSKTPPTDGTDWVVVWWPGNHWTWERESDLEFVDTDPNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUV0</accession>
    <name>A0A231GUV0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA pyrophosphohydrolase</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rppH_3</name>
        <name evidence="5" type="ORF">B7C42_07609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909895.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40348">
        <property type="protein sequence ID" value="OXR40348"/>
        <property type="gene ID" value="B7C42_07609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="16646" checksum="4B53D010E12FEE11" modified="2017-10-25" version="1">MPQKVVKEKVLVYVVRDDKLLVFRHTDYSYEQVGIQVPAGSIRPGESPQDAALREAREETGLNEFKVVRKLGEFSYDISPYRWEVQQRHVFELELCEPAPERWASQEDHDGQGEPTRFECFWIPLEAAHILQSGQGALLGRLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVE7</accession>
    <name>A0A231GVE7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine transport ATP-binding protein ArtM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">artM_2</name>
        <name evidence="5" type="ORF">B7C42_07284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40599">
        <property type="protein sequence ID" value="OXR40599"/>
        <property type="gene ID" value="B7C42_07284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="24838" checksum="1784A134504F959B" modified="2017-10-25" version="1">MEVVRVAEALFAFEEVVVEREGVRALDGFAAVIPEGGVTAVFGPSGSGKSTMLRLCNRLEVPTAGRVLFRGENLAGLDPLRLRRRVGMCFQRPTPFPGTVAENLRVADPHASEARMEQVLARVALTGSWLDRDATALSGGEAQRMCLARTLITDPQVLLLDEPTSSEDAAAARVIEQAVRELADAGMSVLWVSHDPAQVRRIADRVLRIDHGHSRGIEPSLGPDIEEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWH0</accession>
    <name>A0A231GWH0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator GltC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gltC_7</name>
        <name evidence="3" type="ORF">B7C42_07047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503399.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40912">
        <property type="protein sequence ID" value="OXR40912"/>
        <property type="gene ID" value="B7C42_07047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="32943" checksum="CB7C9542211CC4E9" modified="2017-10-25" version="1">MYDIRRLILLRDLAEHTTMTAVSELHGITTSAVSQQLRILEDEVGVVLTRREGRVLRLTNAGRVLVDHTSRIVAALEEAESAVSATSEAVTGVLTVATFRTAQMRLALPVTVRLRADHPGLRVRLVDLRPVDSVPAVRQQDVDLAITYSYSFRSRDLPLGLASEYLFSDPLVLLAPPQWRERVREHGLSSLRDADWITALDGEPSVASVHFACREAGFAPRIEHRSGSFEGMAEMVEHGLGVTIVPEISVADRHTGLVACSIDNGVRHVGVTYRQASLERPAVAAAIRALRSVAQPLRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWJ4</accession>
    <name>A0A231GWJ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="2">1.3.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemY</name>
        <name evidence="2" type="ORF">B7C42_06914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40948">
        <property type="protein sequence ID" value="OXR40948"/>
        <property type="gene ID" value="B7C42_06914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="446" mass="45806" checksum="AB5E0A0D73AC13EF" modified="2017-10-25" version="1">MRVVVVGGGISGLVAAYRLRTALGSELELVLLERRDRVGGILHTGEMAGEPVDLGAEAFVGRRPEIPALLAELDLSEQLVHPAGRRPLIWSGGTAHPLPERTLMGIPAGPEAVAGLVDADTLERITTEPTRPLRWERGGDVTVAELVGDRFGAQVVRRSVDPLLGGVYAGRAESIGVRAALPTLAAALDAGAPNLTRAVADVLPPPSTAPVFGGLRDGYRVLLDALREAAAPKVETDTAATGLTRTATGWRVDPIGAVDAVILATPAPVTATLLGAVAPAAAAVAATIELSSSAVVALGLPADTPLPDNSGILVATGESLRAKAFTLSSRKWPHLAERDVALVRASFGRFGDDTPLSWSDEDLVAAAVADLSTVTGLPIRPQTALVQRWRGGLPQYAPGHTTRIAELESAVAALPGLAIAGAYLHGVGVPACAASGTAAAQRILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWK0</accession>
    <name>A0A231GWK0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="11">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Spermidine synthase</fullName>
            <shortName evidence="11">SPDS</shortName>
            <shortName evidence="11">SPDSY</shortName>
            <ecNumber evidence="11">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">speE</name>
        <name evidence="14" type="ORF">B7C42_06966</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41000">
        <property type="protein sequence ID" value="OXR41000"/>
        <property type="gene ID" value="B7C42_06966"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 11" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="PABS" evidence="13">
        <location>
            <begin position="116"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="11">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11 12">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR41000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="44603" checksum="EA098BBC74EE53A8" modified="2017-10-25" version="1">MTAEFTGWHVLAEFGGVDVALCDDLERLETALRQSLLAAGVTICEVVHKKFEPHGVTVLALLSESHASIHTYPESGDIFVDVFTCGSIGAGATKAVELLQDALQPESVHMEVVQRGHHARRVHEPVGEGLTRVWDLSEVIVDARTPFQHMVIARTAQGVSLFSDDDRQSTEFSQLTYHEAMLVPAYALAAELDNVLIIGSGEGVASQMSVAAGATRVDHVDIDRMEVELCARHLPYGYTPADLEAAVGGDGAIRMHYADGWDFLAEAESAGVRYDVIVIDLPDERVEDAQHNRLYEEEFLTRCKALLAEGGVLAAQAGCPTMWRNETLKRSWQRFTDLFDTVVPYGSDEHEWTFLFGVAERIDDPVAVMCEKLPKLPYRAETVDERALVRGAVEPYALREIAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWK9</accession>
    <name>A0A231GWK9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigB</name>
        <name evidence="8" type="ORF">B7C42_06955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517242.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40989">
        <property type="protein sequence ID" value="OXR40989"/>
        <property type="gene ID" value="B7C42_06955"/>
    </dbReference>
    <dbReference type="GeneID" id="66723714"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="322" mass="35913" checksum="FB0A33F720B0EF48" modified="2017-10-25" version="1">MTSPATTGVRAIDSDLDAQSPAADLVRVYLNGIGKTALLTAADEVELAKRIEAGLYAQHLLETGKRLSATRKRDLAILVRDGQAARQHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYAKGFKFSTYATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKRELHQQLGREASDEELSAESGIPVEKIADLLDHSRDPVSLDMPVGNDEEAPLGDFIEDSEATSAESAVIAGLMHRDVRSVLATLDEREQQVIRLRFGLDDGQPRTLDQIGKLFGLSRERVRQIEREVMAKLRKGERADRLRAYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWM2</accession>
    <name>A0A231GWM2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sensor histidine kinase DcuS</fullName>
            <ecNumber evidence="7">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dcuS</name>
        <name evidence="7" type="ORF">B7C42_06800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41030">
        <property type="protein sequence ID" value="OXR41030"/>
        <property type="gene ID" value="B7C42_06800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="359"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="547" mass="58669" checksum="11117529775F7641" modified="2017-10-25" version="1">MMGVTVTSVTITYVSFTGGPLRAKGRTPRSPARRARGMTLAGQVFVVQLAVLVVVIAVGSALAVWEVRREQDDATARRVTGIAVALAQAPSTTAAVRTPDPTAVLQPVTERIRQRTGVDFIVVMAPDRTRYTHTDVSRIGQPFSGTIDRALAGETFTETYTGSLGPSIRAVTPVVDDTGRVVALVSAGVTRARIGDQVSAQLPLILGAAGAGLLLAVLGAFLLRRRLLRQTQGLGPAELRTLYEHHDAVLHSVHEGLIVFDRDDPEAAVVNDEARRLLELPDGPVRRADLPVSLRHLDATVVRDEMHVTAARVLVVNQDVVSWAGRRLGTVLTIRDHTELRDIMGELDSARGLAESLRAQAHEAANRLHAVITMVELGHVDRAVDFATAELRLSQALIDRLTDAVHEPVLVALLLGKVDRAIERGVELTVAEDTALDSVAPLTAQEVVTLVGNLVDNAVDAVAQDPDAWVEVSVRSDASALVVRVADSGPGMSEEAFAQAMERGYTTKAEHHGLGLALVWRLVTRYGGTLRAERSPESAVVVRIPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWY0</accession>
    <name>A0A231GWY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenolphthiocerol synthesis polyketide synthase type I Pks15/1</fullName>
            <ecNumber evidence="6">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41127">
        <property type="protein sequence ID" value="OXR41127"/>
        <property type="gene ID" value="B7C42_06722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="911"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2647"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="4394"/>
            <end position="4469"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="946"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2682"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="4552" mass="477162" checksum="00BB9C2D47A95EA4" modified="2017-10-25" version="1">[encoded data, 4552 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX95</accession>
    <name>A0A231GX95_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fatty acid metabolism regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadR_11</name>
        <name evidence="6" type="ORF">B7C42_06638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41240">
        <property type="protein sequence ID" value="OXR41240"/>
        <property type="gene ID" value="B7C42_06638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22180" checksum="98C71D63F10A89EC" modified="2017-10-25" version="1">MAASAIGPKGPGGADRGKLEAERRLLDSARDAFAAKGYYGTSTREIAAGAGMSPAAMYIHFSSKQDVLLRLSIAGHASALAALESGAATDGSATKRLRAAVYSFAHWHAENHTTARIVQYERTALTEENRTEVTRLRRKITKLMREIIAEGVRTGEFAVDNVDTTTLSVLSLCIDTVRWFPSRELHTAEAVGAAFAGLAERMVKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXR1</accession>
    <name>A0A231GXR1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SUFU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41355">
        <property type="protein sequence ID" value="OXR41355"/>
        <property type="gene ID" value="B7C42_06498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUFU" evidence="1">
        <location>
            <begin position="38"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="20896" checksum="6E551BBD921A7275" modified="2017-10-25" version="1">MELDQVRSAVLTHFGIPRTGPGFDDTRFDSASVTFLGLEPIDILRIPDGEFVHYVTLGGSRHPMTDSAAALADPVRGPRAELVLTLRGGAGAQAGLPRGLGVLIAAPAVEGVVLQPDALLDLGEPLWHNAPFTAVLLGEAAIAEVPLPEPADPVRFLSVAPITATEAAWVRVRGAAALREAWTEAGIDIRDPHRSAANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXT7</accession>
    <name>A0A231GXT7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacitracin export ATP-binding protein BceA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bceA</name>
        <name evidence="5" type="ORF">B7C42_06563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043039.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41420">
        <property type="protein sequence ID" value="OXR41420"/>
        <property type="gene ID" value="B7C42_06563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="27047" checksum="3C249674607F2DC9" modified="2017-10-25" version="1">MTADALGTEPAAATTLAARATDLMKLYGSGDTQVRALDGVSADFAQREFTAIMGPSGSGKSTLMHCLAGLDSATSGTVHIGDTALTGLSDKQMTRLRRDRIGFVFQAFNLVPTLTALENITLPLDIAGRKPDQEWLDTVIGRLGLGDRLDHRPSELSGGQQQRVACARALVGRPDIIFGDEPTGNLDSRSSGEVLSILRAAVDEFGQTVVIVTHEPHAASYADRVIFLADGRIVDELRDPTADSVLDRMKSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYI3</accession>
    <name>A0A231GYI3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030516981.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41683">
        <property type="protein sequence ID" value="OXR41683"/>
        <property type="gene ID" value="B7C42_06324"/>
    </dbReference>
    <dbReference type="GeneID" id="66719765"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="90" mass="9753" checksum="AEB04D088279F26A" modified="2017-10-25" version="1">MAETKKVTISVPKDDVSTLERWKASGRIDNLSAYVSAALRDRMDRDISLDAIESSFGGVPPLELVNQARRVQGLPPLSAEDLDRRSAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYQ9</accession>
    <name>A0A231GYQ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06054</name>
        <name evidence="2" type="ORF">B7C42_08152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000067">
        <property type="protein sequence ID" value="OXR39777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39777">
        <property type="protein sequence ID" value="OXR39777"/>
        <property type="gene ID" value="B7C42_08152"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41712">
        <property type="protein sequence ID" value="OXR41712"/>
        <property type="gene ID" value="B7C42_06054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="43402" checksum="F0C5BFCC521EDDB6" modified="2017-10-25" version="1">MAHFVGGHIRQHQPERVVLGQARAAQHEISETAQEFGGRAVFCDHIACDDINPFRHRPAARFGTARRPCAHLRGDHRSRGGPDSSGSQVENPVGEVGSDCLGGDGPAVSWCDGRSTPDDGEVALIAQLPVRPPDRGRLYLLGVQPLHQQAGRGQGPACSYVARQDRVTQLMHERPTPLWLTGFAALGSLLDHPQNVGYGTNIGARRIRQCGNEFRIRERGNYRILPGVNTEFDENPVAIGHGCWPGRVQLGRDLIVGATGDDQAEGPELLCAEGYGGAANAGARRPVVGIDIQPSRANGGGHHPGAVADSDPPSEGLHALGHRVLPHGHTAYGGERLGDRAVRQSGGYEEQQGVLVGGHGRSPHGDRRKFGDVQQAAADRLRHHRHTLRDVESPQELGVGAATRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYY2</accession>
    <name>A0A231GYY2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent urate hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.113</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpxO_6</name>
        <name evidence="2" type="ORF">B7C42_06165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.113" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41823">
        <property type="protein sequence ID" value="OXR41823"/>
        <property type="gene ID" value="B7C42_06165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102099">
        <property type="term" value="F:FAD-dependent urate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="316"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="392" mass="41982" checksum="5FB5C9D8004DF3D4" modified="2017-10-25" version="1">MSRFTVIVAGAGLGGLALAQGLRRRGIDVVVYERDSAVDTRRQGYRLHLDAAARHALQRVLPPPLRALFDATAGTPKPRFTVLDSALNERFTQDSAEPAFAVDRLTLRRILLTGLDDRVVFGRAVSGFRTEGDRIVVHFADGDSAGADVLVGADGINSVVRQHYLPHARIVDTGVRQLYGAIPLNARTRNVFDDSMFGIFTMIAGTDGSFVGVAPVEFPQDPATAAARLVPAATLPSVPDYMTCSFGARAEWFGTTEQALRDLDGDGLKDIVTAAVRTWHPRLREIVAACDPDTMFALPLRTSVPIPAWPTTPATLLGDAVHAMSPAAGSGACTALRDAADLSETLDSVVAGRDLRSALHDYEQRLIEYGFAAVRTGAANGRRFLGQNPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ43</accession>
    <name>A0A231GZ43_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41791">
        <property type="protein sequence ID" value="OXR41791"/>
        <property type="gene ID" value="B7C42_06133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="572" mass="59928" checksum="5E015207CDF22552" modified="2017-10-25" version="1">MLSLRGVFRMRPVADTWYQAALCAVIAIGGPEVVLLATGQVQLAFYTSAGGLCALYGHGLPYAARGRTLAWVVLGMFAGTAVALTASALIESAALRVLVIAVLAGLYKLVCDASRMGPPGNIIFTFVVSSAAFIPQRTEQLPGHLALILLGGVLAWCVCMAPALIRPHGPQRLAVARALESTARLLRVPHGDAGVQRARHDAAVAVQAGWTALNRVPATARTAVQRTALAGLLARAETLAATTRTADSGLARYPSDAGSAGAETDFTATRERTRIDAESGADTLEQYARTLRRGREIPRIHCAAAEESEIRGIGLGRTGGARGAALRRVGRAFLPGAAGLPLAARVTLGSAAAGWISLALGVNRPYWAVMTAAVLIVANTAQSWQRTVQRVLGNLVGVALFTAVAPWAHSAVALVVMALVCQVIVEATISRNYWVASVFITPMALAMVEFATPRPASELGLDRWLDTCVGAVIAVLICFAVPNRRVTDRVAAALSELDAAIGRARRAVDSGTGGPADRARLAAALIEVRTCADTAAGEWWSAPLPDERIVAAERTGHQLLDRLPVRTLAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ49</accession>
    <name>A0A231GZ49_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aqpZ_2</name>
        <name evidence="8" type="ORF">B7C42_06210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41868">
        <property type="protein sequence ID" value="OXR41868"/>
        <property type="gene ID" value="B7C42_06210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="229" mass="23170" checksum="08BD84D1C68053E7" modified="2017-10-25" version="1">MPDTTNFATIGADARSADPILEVARRLTVEAIGTFFLVFAVGATARSGTVLAPLAAGVVLMVMVYAGEHISGGHYNPAVTFAVLIRGGIRTGAACAYWLTQVMAGLVAALAVPVVVGSHSPGHIDPTGRVLTDCVAVEFLFTFALAYVVLNVTAGGSRSQFQGLAIGSTVAAGAIIVGGLSGGAFNPAVVLGAITLNLFAPATLLYVPAQLAGAGAAGLVFRWLHPHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZA0</accession>
    <name>A0A231GZA0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative malonic semialdehyde reductase RutE</fullName>
            <ecNumber evidence="6">1.1.1.298</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rutE</name>
        <name evidence="6" type="ORF">B7C42_05930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.298" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042735.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41946">
        <property type="protein sequence ID" value="OXR41946"/>
        <property type="gene ID" value="B7C42_05930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035527">
        <property type="term" value="F:3-hydroxypropionate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02148">
        <property type="entry name" value="RutE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023936">
        <property type="entry name" value="RutE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="203" mass="22410" checksum="4DCAEA0AB9F6FAD0" modified="2017-10-25" version="1">MSTAQPTTHLTLAAEAQDLLFREARTANTFTDEPVSDEQIREIYDLVKYAPTSMNQQPLRIVLVRGAEARAALVEHMLDNNKPKTEKAPLTAILAADLNFHDHLPKVFPHAPDAKDYFTDDDYRAESARFNALIQIGYFILGIRAAGLAAGPMNGFDAAGVDKEFFPEGTHSALVVVNIGKPGPDAWYPRSPRLEYDEVVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZC6</accession>
    <name>A0A231GZC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41925">
        <property type="protein sequence ID" value="OXR41925"/>
        <property type="gene ID" value="B7C42_05909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="16"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="339" mass="36185" checksum="9C6641C838943904" modified="2017-10-25" version="1">MTTMRSVVADTIGEPSAVLNLRVRPIPAPGPGEVRIRVMAAPVHASDLHTIRGRYGFTPEFPAVPGIESVGVIDELGSGTTGLHVGQRVVTIGVTGTWQEFVVAEAARVLPVPAGMSDSTAAQILTNPLTAVVLTGDELDVRPGEWLLQTAAGSTVGQLVIQLGAHIGFKTLNVVRRRSAVDEILALGGTAAICTEDEDLRERVADITGHTGVSKAIDCVAGQVGAEVSRALAPHGELVVYGALSTHRHTEPGKLAIPIFARSLIYETKTVRGFWLFRRLTETPRDRMDAAIDRTLQLADRGVLRVPEGRPISVEKFSEAVYLAEAPEHGGKPLLIFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZD1</accession>
    <name>A0A231GZD1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actinorhodin polyketide putative beta-ketoacyl synthase 2</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_05942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778998.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41958">
        <property type="protein sequence ID" value="OXR41958"/>
        <property type="gene ID" value="B7C42_05942"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="2"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="41748" checksum="5E3B225988371E0D" modified="2017-10-25" version="1">MSVVTGMGVVAPNGLGLDHFWDAVLAGRGAIAPLTRFDTTGFGATLAGQVAEFDAGKYLPSRLLPQTDVSTRMALVAAQWALDDAKVDTTALTDYGMGVVTGNASGGFEFTHREFHKLWSRGSEHVSVYESFAWFYAVNTGQISIRHGMRGPSSALVADQAGGLDAVGHARRTVRRGTPLVVTGGVDSALDPWGWVSHIAAGTVSTATDPARAYLPFDAHAAGNVPGEGGAMLVLEDAAAAQARGVPDCYGEIAGYAQTFDPPPGSPRPPGLQRAIELALADAGLRSDDIDVVFADAAGVPEADRAEAAALEAVFGPGGVAVTATKPLTGRLFSGAGPLDIVTCLLAMRDAVIPPTVATTELAEGCRIDLVRGEPRSADLGAGLVLARGRWGFNSAVVVRAHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZI2</accession>
    <name>A0A231GZI2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778950.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42019">
        <property type="protein sequence ID" value="OXR42019"/>
        <property type="gene ID" value="B7C42_06003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="21398" checksum="5B7779E06DF96529" modified="2017-10-25" version="1">MSDTRRVTANLSITLDGRYHGPAGPGDMGPIVRYATTEVARDQMTRMRENATTAVLGRLNAQGFLGFWPTVAADDSADPRDRGYAKWLVDTEKVVLSRTLTDAPWDRTRIVNAPAADVIADLRRTGSGDILVNSSASVIKDLLAADLLDRLYLIVCPEIAGGGPRLFDDGLPATNWSLSHQETGELGETAVVYDRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZJ0</accession>
    <name>A0A231GZJ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol acyltransferase/mycolyltransferase Ag85B</fullName>
            <ecNumber evidence="3">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fbpB_5</name>
        <name evidence="3" type="ORF">B7C42_06002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42018">
        <property type="protein sequence ID" value="OXR42018"/>
        <property type="gene ID" value="B7C42_06002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012872856" evidence="2">
        <location>
            <begin position="37"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="36874" checksum="2D6C8E48B340D595" modified="2017-10-25" version="1">MVSRPPRKRIARAVAVLSAVITIAAAITATNDRAGADPDDPATVTAPDGSHISDIHRRDDRILDIGVYSAAMRSVTRVQLIRAADPDRPAPTLYLLNGANGGISDGSWSDRTDITDFFADKQVNVVVPFGGASSYFTDWRADDPVLGRQRWRTFLTKELPPIIDSGFGGTGVDAIAGISMAGTSVFQLALAAPGLYKAVGSYSGCVRTSDPQGQLIVDAVVGNRMGNTVNMWGPPTDPAWAANDPYLHADRLRGTAIYVSTGTGIPGPLDTFQGAHGDATQLAYQLVFGAALEGVTNICTHQLHDRLQQLGVPATFDFRATGTHSWGYWQDDLHTSWPLFADALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZN1</accession>
    <name>A0A231GZN1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515774.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42055">
        <property type="protein sequence ID" value="OXR42055"/>
        <property type="gene ID" value="B7C42_06039"/>
    </dbReference>
    <dbReference type="GeneID" id="66724016"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="8078" checksum="7B3D756FFFCBD889" modified="2017-10-25" version="1">MTDSTATTAGRLSEAAWRKSTFSNPSGNCVELADLSNGLVAVRNSRDPEGAVLVYTRPEIDAFLRGAKSGEFDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZR1</accession>
    <name>A0A231GZR1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42117">
        <property type="protein sequence ID" value="OXR42117"/>
        <property type="gene ID" value="B7C42_05716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012872855" evidence="1">
        <location>
            <begin position="32"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="37388" checksum="EB8E47A98A03217B" modified="2017-10-25" version="1">MTSIGLSRRAMLALAASVPLSVVASRRAVAAAPPIRYTMTAFTNDSQTDMWVYESTDATNFRLLQADAYRPPDADPADTPAAAATTKKGLCRDPSVFRHIDGEYYVTYTTAWDGNTIGFARSHDRIHWEFLYEYTIPFDGVTHTWAPEWFVDGDGTVSVLVNINDGTVFRPCVMTATTSSLNRPHWTTPTPLAGVVPAPGGLGYIDTTVTLSQGRYYAFVKNESTKNVEVAVADCLVGPYTFARTGNWAHWGGPDPGQPREGQCVIPLPDGRWRIYLDAYDLDEPTHGHYLYSDTVTGDLLGEWTTPKDLPVLSGFVRHFTVLPEPLNTGPQPAPKPVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H040</accession>
    <name>A0A231H040_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid-associated protein Lsr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lsr2_4</name>
        <name evidence="3" type="ORF">B7C42_05827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779716.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42228">
        <property type="protein sequence ID" value="OXR42228"/>
        <property type="gene ID" value="B7C42_05827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="112" mass="12627" checksum="AEBE54B782274E33" modified="2017-10-25" version="1">MAKKVIVELVDDYDGKSDADQTVHFGIDGVEYEIDLSTKNAEKLRKIFEQWTESARKVGRNRKGAVKSGAARTTPDREQTAAIREWARNNGYEISSRGRIHKDIVEAYNKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0L8</accession>
    <name>A0A231H0L8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Delta(1)-pyrroline-2-carboxylate reductase</fullName>
            <ecNumber evidence="1">1.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.49" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42386">
        <property type="protein sequence ID" value="OXR42386"/>
        <property type="gene ID" value="B7C42_05586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="34794" checksum="025F378C1D931752" modified="2017-10-25" version="1">MSSRPTPLRVLSRSDLADVPIAPNEVVRAVEDAYLALAQGDSDNPRKLSVAHPDGWSVAYAMLGRDGRRRVVAMKTSYKFDPSHDRSTKRYYTTITLYDDATGTPIAMMDCARVGALRTPAVSALLVRETVRPGARSVLLIGTGTQGRNALPHLLAANPQLNRLMVYGTHPEGLDAVGTHLRAHAPHLDLDVVDDPRAAAATADVVLATAGPGTQVALESDDLAPGSVAVLVGYGLAPSTLTDADRVVATSAEQMALTGTDMAGPDGRLRSVDAELPAILGRRATARTSPDERLFVYNSGLVLTDIAVAHALAERAIAEGRGTEVPLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Q1</accession>
    <name>A0A231H0Q1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anhydrotetracycline monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">otcC_4</name>
        <name evidence="2" type="ORF">B7C42_05241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.38" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42465">
        <property type="protein sequence ID" value="OXR42465"/>
        <property type="gene ID" value="B7C42_05241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047670">
        <property type="term" value="F:anhydrotetracycline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="31"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="501" mass="54535" checksum="9103B46A2C052849" modified="2017-10-25" version="1">MLHNRRANATTCGNRLFRGLCPHRVEWGFMIDVIVAGAGPTGLMLACELRLHGLNPVVLEKETEPTKVVRALGLHARSIEVMDQRGLLERFLALGTKYPVGGFFAGITAPQPELDSAHAYVLGIAQTVTDRLLAEHAAELGVDIRRGHEVVGAIQDEDGVTVELADGSRLRAQYLVGCDGGRSTVRKIAGIDFPGEPSRVETLLGEVELDAPLETVTAVVTEVRKTQRRFGVGPSGNGTFRFVVPAEGLSEDRTVPPTMEEVKRQLVATAGTDFGVHSPRWLSRFGDATRLAERYRSGRVLLAGDAAHIHPPVGGQGLNLGIQDAFNLGWKLAAELAGWAPAGLLDSYESERHPVAADVLDNTRAQMELMSLEPGPRAVRKLLTDLIDIDEVNRRLTEKITATAIRYDFGEGHELLGRRLRDVRLKDGRLYELMHAGRGLLLDQTGRLSVAGWADRVDHVVDVSEELDAPAVLLRPDGHVAWVGSDQDELLAHLPTWFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H122</accession>
    <name>A0A231H122_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42546">
        <property type="protein sequence ID" value="OXR42546"/>
        <property type="gene ID" value="B7C42_05323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="18146" checksum="DB210ACD90F57EF0" modified="2017-10-25" version="1">MVSSISEITPLRTEELITELSTGIDDLSGVEGKTTTTVALDFGRITIDQNLVLYLFGTPGQDRFWFLWDELARGALGAVVIADTRRLENSFAAIDFFERRGLSFAVAVNCFDNAPVYTTEEVRDALDLDAHIPVVLCDARDRSSCKTVLMTLVEHLIARATSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H189</accession>
    <name>A0A231H189_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="4">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42577">
        <property type="protein sequence ID" value="OXR42577"/>
        <property type="gene ID" value="B7C42_05354"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="39377" checksum="3B7576BD706E2068" modified="2017-10-25" version="1">MRSSKPTTYPPEQRLPAPDRKDCALPREPGRRPRATTDATPGVRSAGALLADARTAIAPVLRAAVATLGHPLDRMAGYHFGWCDAEGNLRAGAHGKGLRPALTLAAAAACGAPAADAVHAGAAVELLHNFSLVHDDVMDADPLRHGRPTVWRVWGTTNATLLGDALQALAFAVLSDGGVPEETGAAAVIRLARTAATLCHGQYQDCDFETRPDVSVEDYLSMAAGKTAVLLGCSCALGALCAGADSRTVAAFNTFGRNLGLAFQLVDDAIDIWGDPAVTGKPALSDLAARKRSFPVVCALASDTDAGRELARLYNEPRPMTTVDVARAAELVAAAGGRELTRDYADRALRSALAGLPSGIARGDLETLAHVVVRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1B2</accession>
    <name>A0A231H1B2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carnitinyl-CoA dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">caiD_7</name>
        <name evidence="7" type="ORF">B7C42_05423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.149" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42645">
        <property type="protein sequence ID" value="OXR42645"/>
        <property type="gene ID" value="B7C42_05423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLP1_add_C" evidence="6">
        <location>
            <begin position="646"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="991" mass="102760" checksum="479136422AB7B8E9" modified="2017-10-25" version="1">MSPLPGSDRIRAARTKLEAGNALFAAVRKDPRIARDLITGLVGAARSQSAPEAAHAEEADGYLTPAGVSDYAKSAHARRSIAVAPDTVAAYLSDLSRLADWFTLHAGWRGQAPGAVREGLTFTQQALVMGIPAELRWTVVEAGERGFALAGEGPQGVRLGYWLTVAGSGDQATVYFDAGLGGPPVEGPLGASVARSLGEAMEQSLARLPEAIAAAGPVRKRAAQPIRHRASGTEIDPRTPVLVGVGQITQRTPDSGYGDPAALAVTALRRAAADTGAGEDLLRRADAVFAVACTSWQYRDMGAVIAQRLGVAGVDTAQSSPFGGDGGQLVINEAAAAIAAGDYDMVLVTGAEAGATQAAAQRAGVELSWPQQGSEVAPIRSIGIDKPANNPAETAAGLIAPINMYALLESANRHRLGRSPGDHAAAVAELWSRLSAVAARNEYAWQPEEFDADRIATPGPDNRMVSTPYTKLECANLTVDMASGIVMCSAAAAQEAGIAQDKWIFIHAGASGHDEWFTSERAELAASPAIATLGRAVLEHSGIGVDALTHVDLYACFPVAVQIAARELGLAIDDPARPLSVTGGLTFGGGPGNNYGGHAVATMVSRLRAEPGTFGLASSLGWYVTKHALGVYSSLPPAQPYRHLRPIIENPPARPARSTHDGPAVVEAYTVAYARDGQPEAAILSLIEPAGGRILLRNTDSELIAELVDGDLLGLPVTVSGHDISVERRERVELPAPPAPPVLVERRGAITIITLNRPQVRNAVNLATALGLERALDAYEADPSAQVAIITGAGGYFCAGMDLKAAARGETPMTEKRGPLGITAQPPVKPLIAAVEGPALAGGCELALAADLVVAAQDSTFGIPEVKRGLVAVGGGVLRLAQRLPRAVAMELALTGDPISADRAAALGLVNQVTESGKALDAALELAQRIAVNAPLSLAASKRIIDESPDWSTDVAFTRQLEVSGSALSSEDAAEGVLAFAQKRTPEWKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1F7</accession>
    <name>A0A231H1F7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776826.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42680">
        <property type="protein sequence ID" value="OXR42680"/>
        <property type="gene ID" value="B7C42_05016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="16635" checksum="611EB4ECB7CB1F94" modified="2017-10-25" version="1">MSTTDTSAFIPADYVIAVDHVGIAVPDLDTAVAWYSDNLGMVETHREVNEAQGVHEAMLSLPGSGDDATALQLLAPLNEESTIAKFIDRNGPGLQQLAYRVTDIDAVATFLRGRGVRLLYDAPRAGTANSRINFIHPKDAGGVLVELVEPAANPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1N8</accession>
    <name>A0A231H1N8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42756">
        <property type="protein sequence ID" value="OXR42756"/>
        <property type="gene ID" value="B7C42_05094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="170" mass="18443" checksum="DE20957E2419891F" modified="2017-10-25" version="1">MTAAGLDRTVTATALDDADRLGAQLIRFVRAVNRAKTQLSKAGPDGLEKLAYAMLFCLVHDGPQRTGKLAEQLHAEISTISRQTRSLVAHGLVERRADPVDGRACVLAATDEGSRVFAENRRLRNLWIADVMADWPAADRSTLIALLDRLNCGIESTPPSTAEPKQGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Q6</accession>
    <name>A0A231H1Q6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_15</name>
        <name evidence="2" type="ORF">B7C42_05123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42785">
        <property type="protein sequence ID" value="OXR42785"/>
        <property type="gene ID" value="B7C42_05123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="27670" checksum="7488E2458551F5B1" modified="2017-10-25" version="1">MAITLPSWSRNMSRRSAGGLQTIGGLFAMSADAVKFAFRRPFQTREFLEQSWFVARVSLIPTLLVAIPFTVLVSFTLNILLRELGAADLSGAGAAFGAVTQVGPMVTVLIVAGSGATAMCADLGSRTIREEIDAMEVLGIDPVQRLVTPRMLASGLVALLLNSLVCIIGIAGGYVFSVYVQNVNPGAFANGITLLTGLNEVVISAVKALLFGLVAGLIACYRGLIVSGGAKAVGNAVNETVVYAFMALFVINVVVTAIGIQMTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1R4</accession>
    <name>A0A231H1R4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42794">
        <property type="protein sequence ID" value="OXR42794"/>
        <property type="gene ID" value="B7C42_05132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="34713" checksum="5BEF7BD1F2741DEF" modified="2017-10-25" version="1">MTSGKHPTPPDTGDISDRDLLLAAVEAEAEAEAADAVAAAARARARAATLRRRAEAAAHPSAPSDANDTPDSDDPAPDTEGDSAASGRDVASTRQPAPSAERTPDDAVSAPEGPATQSLSRPRSSTGGDAATDAAPESDAAPESEAEAETGTDAKTEGSRRRKRPRLGAVRHIRRRTAGVAVAAIVVCAGLGSSGYMMWRHHDVTANQHREAEFVAAARQGVTTLTSLDFNHAADDVKRVLDDSTGSFRNDFQSRADDFAKVIQQSKVATQGRVNAAAVQSMTDDSAVVLVAATSEVTNSAGAKQEPRAWRLSVTVERVDGRLKMSKVEFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H219</accession>
    <name>A0A231H219_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase 2</fullName>
            <ecNumber evidence="3">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42893">
        <property type="protein sequence ID" value="OXR42893"/>
        <property type="gene ID" value="B7C42_05232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011262812" evidence="1">
        <location>
            <begin position="29"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="40"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="31372" checksum="83FC0ECDC645A769" modified="2017-10-25" version="1">MPHRTTRTLALLALAGAAGLAPTHGAAAADTPRDAEYVSLGDSYVAVGSNLNTYNRDPDCGTAPDNVGHLVAAQLHGVSFDDRACGGADTSDITSTTTRSDPQIDGLSPKTRYVSISLGGNNDNVFGEIVNNCLMASHPADTCTPQFRADEARKLDDLGQTLDSAYTAIRTKAPNATIIVLGYTRILPDSVQGCFAAPMITQSLVDIGNDLQHQLDDVVTAAARRAGFVMVNQWDAQDDHHSICAPLGQTYVSMTGLLPTEQGTPVHPTIQGRRYAAQLIAHAFLATTNTRQTTPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2I4</accession>
    <name>A0A231H2I4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ethanolamine ammonia-lyase small subunit</fullName>
            <shortName evidence="4">EAL small subunit</shortName>
            <ecNumber evidence="4">4.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">eutC</name>
        <name evidence="6" type="ORF">B7C42_04947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ethanolamine = acetaldehyde + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15313"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="4.3.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
        <text evidence="4">Binds between the large and small subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine degradation; ethanolamine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.7" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43061">
        <property type="protein sequence ID" value="OXR43061"/>
        <property type="gene ID" value="B7C42_04947"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008851">
        <property type="term" value="F:ethanolamine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00601">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009246">
        <property type="entry name" value="EutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042251">
        <property type="entry name" value="EutC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042255">
        <property type="entry name" value="EutC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39330">
        <property type="entry name" value="PTHR39330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05985">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1 4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="2 4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="372" mass="37225" checksum="7B6DB2413C2714E2" modified="2017-10-25" version="1">MSAEHRGGGRARAAGSIVGGTRAADAGAATGRAHSVGADGVSAAELSAADAEKGGAGRASAGPASADRANAENGYAPGGCVAGEGATTMGAGAMSAGDEGRAGAGRARDAGRAGADGEPFWRELRGVTQARIGLGRTGDALPTARVLEFRAAHSVARDAVHTSVDVDALCERVVAVGIGTPIRVRSRARDRAEYLRRPDLGREPEDSSAIRNTVSPSAFDVGFVLADGLSPRALATHGPDLLAALVDELAPHYALAPPVVATQARVAIGDHLGAALGARTVLVLIGERPGLSVADSLGIYLTHHPRPGRTDAERNCVSNIHPPEGLGYRQAAAVVAGLVAGARALGRSGVDLKDGSGVDAVKSAVVEGISKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3F4</accession>
    <name>A0A231H3F4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TetR_C_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43394">
        <property type="protein sequence ID" value="OXR43394"/>
        <property type="gene ID" value="B7C42_04261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_1" evidence="1">
        <location>
            <begin position="76"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="24650" checksum="CE4AD614F6876BF7" modified="2017-10-25" version="1">MQTSRRGRGRPPRLSRDRIVAAARALPPETLTMKAVADALGVDRKSLNYYVSDRDGLLELVALDAFETEIRRLALPADGDWRQLLHLFAVAVAEALTQVGVLIYHVRFRGRGGLSTLAEIERIFQSLVSAGFEPMEAGRTLRLLADIAYSAARESAEATRGHVDLQAEHVARTLNSEVGEEFPLLRQVATTRESTGRVGEQFEFDVDLVISGLERKLEARGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3F8</accession>
    <name>A0A231H3F8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782502.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43410">
        <property type="protein sequence ID" value="OXR43410"/>
        <property type="gene ID" value="B7C42_04277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045512">
        <property type="entry name" value="DUF6480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20088">
        <property type="entry name" value="DUF6480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="7552" checksum="99A4C4D5EF0FC935" modified="2017-10-25" version="1">MSAMDPDPAKTPDLEPGGGVPPGSTPPDTAQTSGLSAPEPSTRHHFPVSGALLIVIVAAIVVVFVVVAIALIVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3H5</accession>
    <name>A0A231H3H5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43397">
        <property type="protein sequence ID" value="OXR43397"/>
        <property type="gene ID" value="B7C42_04264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="14564" checksum="D11CA944CFF4B1FA" modified="2017-10-25" version="1">MASTRPRVQVRRIYDDPDPDDGMRVLVDRLWPRGMSKENAHLDEWCKTIAPSTELRTWYAHDPAKFDEFGRRYREELHDPERAADLDHLRELAGRGMLTLLSATKRIDISEAAVLADLVEKKSAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3L0</accession>
    <name>A0A231H3L0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43469">
        <property type="protein sequence ID" value="OXR43469"/>
        <property type="gene ID" value="B7C42_04336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="15270" checksum="16D837E032F59ECA" modified="2017-10-25" version="1">MKFVSIRIITADVACLAEFYERATGLRARWATEDFAELETGVATLALASTRTVALFAPDSARPSDNHTVITEFLVDDVDRVYRELSGAGTEVVAEPATMPWGNRSLLVRDPDGNLVNFFTPVTPAAIAKFAGRAVPVTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3R4</accession>
    <name>A0A231H3R4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43402">
        <property type="protein sequence ID" value="OXR43402"/>
        <property type="gene ID" value="B7C42_04269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="30441" checksum="A82F3AD9A7937E63" modified="2017-10-25" version="1">MAWLAIGRGLFSGPDLDAGGQFAVNFSIYWPFLFVISPVLFVTAIFGLLPYPFAPGGTIAGGLIASFFAQWVGTELSLSDYKPELPGCLDTSVAAACSAVGAAFTAAFVHLYSNRSGRARSASMRGGAALAVAVLVSAVVTIPPLIAGSGTPSGVLAGFVTNSHCGRKVSDWTDEGQATVYTGDATQWAPLKNGPESVFGVLVTLRNGTGSVETTPPTAMSFRDELPFRSGPPATELLLHQPGTGNGFAFTRLRDPECEDGSSRVVSATYHYEEYGGTSDTRLRGKVSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3X4</accession>
    <name>A0A231H3X4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43544">
        <property type="protein sequence ID" value="OXR43544"/>
        <property type="gene ID" value="B7C42_04412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325509" evidence="1">
        <location>
            <begin position="32"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="19357" checksum="39B7A6C828FF43D2" modified="2017-10-25" version="1">MRFNSATARAALRLAPAIVAAVTLATTGCSAVEKGVDKGVQVAKDHNKSDTARAKVGDCINVINASAVDSDTEPVACASDKAVYKVAQVHNDKVDCGADFTSYEETLNGGTLAYLCLAPNFKAGLCYADSPLSGYKYADCTSSEASFRVVQRIDGQSDDTLCGPESDSVITLSDPQTTFCLAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H408</accession>
    <name>A0A231H408_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ribH</name>
        <name evidence="8" type="ORF">B7C42_04452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502603.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43584">
        <property type="protein sequence ID" value="OXR43584"/>
        <property type="gene ID" value="B7C42_04452"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="16545" checksum="8FFE008B90D096C1" modified="2017-10-25" version="1">MSGTGVPEFALADAKDLRVGIVASRWHTTICDTLLANAERVAREAGVEQITVVRCAGAMELPVVAQALARTHDAVVALGVVIRGGTPHFEYVCDAVTAGLTRVSLDEGTPVTNGVLTVNTEEQALDRAGLPDSAENKGEQASAAALDAALTLRALRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H409</accession>
    <name>A0A231H409_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43502">
        <property type="protein sequence ID" value="OXR43502"/>
        <property type="gene ID" value="B7C42_04369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556651" evidence="3">
        <location>
            <begin position="26"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="491" mass="49865" checksum="180120EC303A7328" modified="2017-10-25" version="1">MVRRIVTILAVVFTVMIATPTVAYGQTYGFDQTCNEIHDDLDGLGLPGVSLGDAASAACKAGNAATHPGDAANAVKDKAWDSTFGKVVDSLMNGLGEALILALTFWMKVPNDRISDGGALFQKINDYTYQAQILLLIVSVILSGARLAEARRGAALSEAAESFRMFARVIFSSWMLGAVVVAGTQASDRFSQWVIEDATNGNARSLAELMVKTSKLQAFSPGLVLIIAIVGLLGALAQIVLAIVRQGMLVVAAGVLPLAAAASGTSTGRQAYPKLIGWIIAFMLWKPVAAIVYMIAFVTAGDTNSTTPTSGLPDADQAQRMLVAIVLLCSVAFVLPALMRLVTPAVAIAGSGGSGLGATGAVLLGAAALGAVGTKAVGVRTQAAAGAPGYVGRNGGQRPPGGTGRGGSPRPVPPRGPRPGGGGGGQQAPASPRGPGGAAAVPSGASRVMNNIATARAAGAHLNRADEAMGDIAGDRWANRAPDLGRSTIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4C7</accession>
    <name>A0A231H4C7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c biogenesis protein CcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ccsA</name>
        <name evidence="8" type="ORF">B7C42_04038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43803">
        <property type="protein sequence ID" value="OXR43803"/>
        <property type="gene ID" value="B7C42_04038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="87"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="36052" checksum="7F1C3153534C32BA" modified="2017-10-25" version="1">MPIDETLAGYSNLAFKTAFVVYLLVLAMLIVQYASAKKKVTSAQERERELVGVGASGGVSADRPIGPGKLEPAPKRSLAEQLGNMAFAVLFVAIGLHLASIVLRGFATHRFPLGNMYEFITMATAAAMVTGLVFIHDRRYRAMWVFLLVPVLILMFLAGQVLYADAAPVVPALKSYWLPIHVTIVSIGSGIFMLSGVASLLFLLRMNQPEGRESSNPLGALARRLPDARTLDRLAYRTTVVAFPLFGTGIILGAIWAESAWGRFWGWDPKETVSFIAWVIYAAYLHARATSGWRETKAAWINVAGFVAMLFNLFIINIVVSGLHSYAGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4G1</accession>
    <name>A0A231H4G1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Siroheme synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysG_2</name>
        <name evidence="7" type="ORF">B7C42_04024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43789">
        <property type="protein sequence ID" value="OXR43789"/>
        <property type="gene ID" value="B7C42_04024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="6">
        <location>
            <begin position="263"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="520" mass="55282" checksum="9C5CBF5584AE60BC" modified="2017-10-25" version="1">MSRATKKHPGRILFVGSGPGDPALLTVRAREVLGRARLAFTDPDVDKGVLAMIGTAVEPGADGESAVDVRPALGEPAEVAKTLVHEARAGHDVVRLVSGDPMTTDSVISEVNAVTRSHMNFEVLPGLPSATTVPAYAGIALGSSHTEVDVRGEVDWASVAAAPGPLVLHATSGHLAETASALVEHGLAPQTPVAVTVRGTTRQQRTIEATLATLNSAASELVGPLVVTVGKEVEKRSKMSWWESRALYGWTVLVPRTKEQAGEMSEKLVMHGAIPMEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGEATADKVRSFGINPELVPSGEQSSEGLLADFPPYDDVFDPVNRVLLPRADIATETLAEGLRDRGWEIDDVTAYRTVRASPPPAETREMIKTGGFDAVLFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPEIAQVGPLVDALAEHAAHLRAEGLLPPPRKKSRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4S5</accession>
    <name>A0A231H4S5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43792">
        <property type="protein sequence ID" value="OXR43792"/>
        <property type="gene ID" value="B7C42_04027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="17670" checksum="6E00EECB46FCCAF9" modified="2017-10-25" version="1">MPAEPGIRTRPEDVRTACQLWWAVVALGVLRLILGAVDRLGNRRQVAQDFYDQLHGERPDFSVAQMELVVSILEVLVLTYGLAVGIGAVAVVHELGRGRLWARTVADVATVVLVLGAVGSMFGLGAVAGGPAVLIGAAAILQAVLACGAVFLCRRKESEAFFRANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4X4</accession>
    <name>A0A231H4X4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43921">
        <property type="protein sequence ID" value="OXR43921"/>
        <property type="gene ID" value="B7C42_04160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="14115" checksum="09219F76DF36C103" modified="2017-10-25" version="1">MSLAPVDLFARGIRMLPDGRVFDEQRRMSGEVEGWTLAAFRVATDADVHGDHWEMHPSGEELVAVLSGGIRIYLRESGDPAASVSLRSGQAFIVPRGRWHRIEVDEPSELMSLTLRRGTELEKRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4X7</accession>
    <name>A0A231H4X7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043270.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43890">
        <property type="protein sequence ID" value="OXR43890"/>
        <property type="gene ID" value="B7C42_04129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="19623" checksum="8763438EA8087CFB" modified="2017-10-25" version="1">MRRIVVGDDGTGQGRVLSDENVEPLTLALLPGAQLHRMWEVDELPALPVDRMPSDVDTSYFPGPGGVRFGFISVPPGLSYEPPAELSEAEMAVVAAEAEQKLPGMMAAFDPARPGVHATESVDFVVVLSGEGRLRIGDDVDVALRPGDCVVQHGAPHAWFNDGTEPFVFCYTLCGVERNAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H519</accession>
    <name>A0A231H519_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">betI_15</name>
        <name evidence="6" type="ORF">B7C42_04184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43945">
        <property type="protein sequence ID" value="OXR43945"/>
        <property type="gene ID" value="B7C42_04184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="230"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="45281" checksum="BD6703E77C96F4DE" modified="2017-10-25" version="1">MSVERGTASPAEQPTTKPQERVIRRRPKNRRAQIAATSAAAFGSLGYHGVSMEDIASRLGISSAALYRHYPSKYALFREELLRLGALTVESTTVAPEAAELPAQQRLAGVLDAMIAATIANRPTVTLARWEGRYLDDTDRATLDEQFTTSIRALAGLLGELRPELTRRDRLVRAVALLSIVSSIGDHHATLPVKSLTAVLNSAAWAIIGAELPDAAPSAGTPRAAEIPQSFKHELLLKKSVELFHQRGYPNVSVEDIATAADLSAASAVYRYYRSKSDLLAAAFRRAADRVSGAIGPATASSKSPAEALSKLIGLYVTGSFEERELTFVYYAEFSHVPPEERTVLRNIQRLIVAEWVKLLVAVRPELSEAQARILVQAGFGLVVDLGRVFGDDENLCPPQRVMALMEVVLFGSPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H556</accession>
    <name>A0A231H556_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR43994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43994">
        <property type="protein sequence ID" value="OXR43994"/>
        <property type="gene ID" value="B7C42_03550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10499" checksum="915D3B6226F0E2E2" modified="2017-10-25" version="1">MVVPEQVRNVGTYIYGLADTLSGALDSAAKDVAELLNGSWTGDYADEFSDGWDEVHDGGRQIFAALTTMAEKLGVTAETFATVDQASADALGIPKLNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H592</accession>
    <name>A0A231H592_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44024">
        <property type="protein sequence ID" value="OXR44024"/>
        <property type="gene ID" value="B7C42_03580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CHAD" evidence="2">
        <location>
            <begin position="198"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="453" mass="50758" checksum="921278225C3C6402" modified="2017-10-25" version="1">MATHVNERERKYQLPITGGVPLDDMPGMTLDPLTEEQVLDAVYHDTADLRLAHKGITLRRRTGGDDAGWHVKVPLGEDTREEIQVPLGRGGKSAPQELTDMLAGITRGRPLAPVAHIRTKRRKWRLLDDRGDVAAEIVADSVSGQTLGESSSVMSWEEIEVELTGGGPDVFDSVEKRLGKPSDAPPKALRVLGVRTTQRPPERGLQGYMRKQADKMIEQDILIRRHSPDSIHQMRVAGRRLRSILQAFKGSRDLRNELKWLSGVLGDMRDLEVLHDHLVAEVRALPDELVIGEVRRRLTESFVPRRSAARTDVLEAMNSERYFALLDCLETSHRLPLNRKKGKGLRKTRRRVDRAVDAIGRLGTDRGLHEVRKAAKRTRYAAEATGKKKLARRMKKLQKSLGVHQDAVVARAEVRNLGVQAHLAGENAFTYGLLYGREVQRAEKVRQSLGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H598</accession>
    <name>A0A231H598_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43962">
        <property type="protein sequence ID" value="OXR43962"/>
        <property type="gene ID" value="B7C42_04201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="21540" checksum="A1C39510E8022EEA" modified="2017-10-25" version="1">MPAPDAASMLQPMTDRWTSADLAHLPENGIRYEVLNGQLIVDAAPKPRHQVVMQWLLVELLTKAPKDVWVMSGVGVLVGDDEPIPDLIVGTGTRPMDDRGVPVQQVLLAVEIVSGSTTLQDRMVKPAFYADAGIPNYWRVEINSFKGRLPGEDLPVLFAYALGEDRAYELVQRAAAGAEVTLHAPFEFAVDPATLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5G6</accession>
    <name>A0A231H5G6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rsmH</name>
        <name evidence="7" type="ORF">B7C42_03681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777399.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44124">
        <property type="protein sequence ID" value="OXR44124"/>
        <property type="gene ID" value="B7C42_03681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="35193" checksum="88D06AA7D7762D1F" modified="2017-10-25" version="1">MNHDSDRPRHVPVLLRRADEILGPALESGGVLVDATLGLGGHAEHFLRTYPAIHLIGLDRDTEALRLAGERLEPFADRITLVHTRYDGLPGALRQAGLPERGSVRAVLMDLGVSSMQLDEAERGFAYSVDAPLDMRMDPTADLTAADVLNTYSHGDLARILKTYGEERFAGRIASEILRRRAQRPFTTSAQLVELLYDAIPAATRRTGGHPAKRTFQALRIEVNRELESLEAAVPAALAALEVGGRIVVMSYQSLEDKVVKQIFAQASASRTPLDLPVELPGMGPEFAILTRGAEKASETEIEENPRAAPVRMRAAERIQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Y7</accession>
    <name>A0A231H5Y7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775713.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44423">
        <property type="protein sequence ID" value="OXR44423"/>
        <property type="gene ID" value="B7C42_03212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="23019" checksum="0BEF3E67102184FB" modified="2017-10-25" version="1">MTDIHESFLRFIDDTGSRHELALTPDHQRITIGRSPQADLSLGWDAEVSRLHAAVEYLGAHWTIVDDGLSRNGTFVNGERLVGRRRLEAGDRIRVGTSTLSFHDYTGTVDDATRTSVGSVPSPRSLTDTQRAVLIALCRPYRDNTEFATPASNQQIADELYLSVDAIKTHLRALFSKFGVEDLPQNQKRVRLAALAIQNGIISHRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H612</accession>
    <name>A0A231H612_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major membrane protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mmpI</name>
        <name evidence="3" type="ORF">B7C42_03880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44319">
        <property type="protein sequence ID" value="OXR44319"/>
        <property type="gene ID" value="B7C42_03880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="90"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="468" mass="51899" checksum="FF9E1F2C23CAB148" modified="2017-10-25" version="1">MTLELPAQTDNHDRKSLSTAAAHQLAHTTKSEPQMQGISSRWLTRMLPWTQVEGGIYRVNRRLTHTVGNGEVEFVIDGSHAHVIPLELQELPALRELDDEEILAAMAGQFIQRDLEPGTVLAEFGNPIDQLMLIVHGKLSKIGTGEYGESTKLGILGDGDYFGDAMLTDRDAIWPVTVKTVTPVTLLTLPRTAFDRLVDQAPLLGEHLSRVSQSPVRPQNKYGEANIEITSGHIGEPMLDGTFVDYDSSPREYELSAAQSVLRVHTRVADLFNDPHNQIEQQLRLTIEALHERREYDLVNSPDFGLLNNCDLKQRIYTESGPPTPDDLDELLSMRRSTKFFLAHPKAIAAFGRECNKLGLYPDPVDIEGRRVPAWRGVPILPCGKIPVSEKQTTSILAMRVGEKDQGVIGLHQTGIPDEYEPSLNVRFKGIDDQSIISYLVSCYYSAAVLVPDALGILDNVAVARQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6I9</accession>
    <name>A0A231H6I9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44377">
        <property type="protein sequence ID" value="OXR44377"/>
        <property type="gene ID" value="B7C42_03166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8609" checksum="6EA0A02AD15A5C3A" modified="2017-10-25" version="1">MDLPERRNEDARKVARGADDDGPAYLHHTDGTWSLVGPDGWTMDPADLPTEPAETAAITAPSPETVDVEPVSVRDREIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7G9</accession>
    <name>A0A231H7G9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator HmrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hmrR_1</name>
        <name evidence="3" type="ORF">B7C42_02739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44785">
        <property type="protein sequence ID" value="OXR44785"/>
        <property type="gene ID" value="B7C42_02739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="15294" checksum="B8305FCB9BB8E7B9" modified="2017-10-25" version="1">MLIGELAARTGVTTRALRFYEEQGLLTSGRTAAGYREYEEDAVARVRNIRELLHLGFTVEDVRAFAPYLDRELPDVFPYEPRCASGYAAVGPPRVAELNERIARLTRLRDQLVSRMPWLDPEQPPGDEPVIPPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Q2</accession>
    <name>A0A231H7Q2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44820">
        <property type="protein sequence ID" value="OXR44820"/>
        <property type="gene ID" value="B7C42_02774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="10756" checksum="3450A47D67794CEB" modified="2017-10-25" version="1">MTPDTRRFSVDLDKLDGLAARIRGFAGFIDDQLKAIDGKAKEAEGHWTGAAATAYSDAHREWLSGAAELADGLKTLEDAVRHVHEAHTTAVSDNLKILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H866</accession>
    <name>A0A231H866_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44982">
        <property type="protein sequence ID" value="OXR44982"/>
        <property type="gene ID" value="B7C42_02939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="401" mass="43734" checksum="9D8EA4716821AAD3" modified="2017-10-25" version="1">MTSSVPVVIAWPVIVATVLVVAARWVWFDDTAAERYLNATLTIIAATQVLREDVAQRAIVAVLPTTVTTVQQISLCTIVVSIAPFLCVIDLLSGRAAGDVRSRPWRYHLIAAALSIAILAAGTRARHEQRPVEVSGGWAEVLVWLAFSILPLFLAVRMIARCWSEYRQHGVTRGEKVVLAGIALAGAAIGVTTAIATGLALVQQIGVLDSVDYRLRTNSRNFFWIATVIAIVSSAPVVEALLGVAGFDATGRRWRRLRPLWESMTTMFPDSRLPMDPGSRRITRLRLHRTTVEIRDAILELRPYCADVDPAEFANFAAAERIPPRDAEPAGYALQLALAARERSRTGDPPGGAAATPVSDSATLDDEVDELLRVARWWPAATRFADRPRPLPRAAQEAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H867</accession>
    <name>A0A231H867_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron-encoded protein LtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ltrA_1</name>
        <name evidence="2" type="ORF">B7C42_03091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45134">
        <property type="protein sequence ID" value="OXR45134"/>
        <property type="gene ID" value="B7C42_03091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="94"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="478" mass="54395" checksum="0CD62E4163513466" modified="2017-10-25" version="1">MPEGSSVNTDELAFELMVAERRVLEIQTKLHRWAGDDPHRRFDDLFNLVADPAFLLVAWDRVRNNRGARTAGVDGETAHYIEAERGTAEFLAQLRVDVKARSFQPLPVRERAIPKAGGKLRYRGIATIRDRVVQASLKLVLEPVFEADFRPCSYGFRSNRRAHDAVAEVHHFASRSYEWVVEGDIKACFDEISHSALMDRVRRRVGDKRVLALVKAFLKAGILIEDGTLADTSAGTPQGSILSPLLSNVALSGLDDFVAQAPGGPAASNYERAKRRRHGLPNYRLCRYADDWCLVVSGTKAHAEALKEEITGVLTTMGLRLSPEKTLVTHIDEGLDFLGWRIQRHRKRGTNKHYVYVYPAKKALVAVKAKIKTWCRKGTNLPLKVLLIHLNRMLRGWTAYFKFGCSNATFSYLRAYLWQEIVRWQERKHRRTPWKQLRRRYGIWPGDDGVTLFDPARVSAKRYYYRGTKIASPWPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8T4</accession>
    <name>A0A231H8T4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45433">
        <property type="protein sequence ID" value="OXR45433"/>
        <property type="gene ID" value="B7C42_02558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="11533" checksum="915411EC96CAFCBF" modified="2017-10-25" version="1">MPFHADAEQLANFVREMQDKHDAIGRMITNAHNHATTLQGPAFQGGAGTAFQNTFEQFLTSANKMNEALMQNSQNLQSAGKKYAEMEETNLSTLNQQSNSLNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H911</accession>
    <name>A0A231H911_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain type dehydrogenase/reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45339">
        <property type="protein sequence ID" value="OXR45339"/>
        <property type="gene ID" value="B7C42_02464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="29603" checksum="F1E9988D30396E90" modified="2017-10-25" version="1">MGALDGRVAVITGAGRGIGREHALLFAREGASVVVNDLGGSNAGEGADAGPAQEVVDEIRAAGGKAVANTDNVAQWDGAKNLVDQAISEFGTLDVVINNAGILRDGFIAGLEESQWDAVIAVHLKGHFNVLRHAAAYWKDQSKAGKQPNAAVVNTASASGVTLPNAGQANYGAAKAGIAALTLVAAEELERYGVRVNAIAPMARTRLTLATPGMGAIFAAEVGEGEFDAFSPANISPLVAYLATDKCPVTGKVFAVQGGAISELGGWHDVKTIETDGPWLIDDIAARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H934</accession>
    <name>A0A231H934_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45341">
        <property type="protein sequence ID" value="OXR45341"/>
        <property type="gene ID" value="B7C42_02466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15433" checksum="CC64FB862A96940E" modified="2017-10-25" version="1">MGHIEATKNLNATPDALWAVVSDPQTWDKWFTIHERWMEEPPATLTTGSKLVAKIMMLGMANKMEWVVEEVNAPNNLVLSGAGMAGVKVKFSFDIAPEGAGSRFSVSGDFEGALIKGALGKAVEKDGAKQLDTTLEQLDALATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H945</accession>
    <name>A0A231H945_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigD_1</name>
        <name evidence="8" type="ORF">B7C42_02503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513512.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45378">
        <property type="protein sequence ID" value="OXR45378"/>
        <property type="gene ID" value="B7C42_02503"/>
    </dbReference>
    <dbReference type="GeneID" id="66719080"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="20589" checksum="C976F9705B25DE7E" modified="2017-10-25" version="1">MTHSGEELDAAVAAAAQGDRSALAQVLEIIRPLVVRYCRARIGSAERGQLSADDVAQEVCLAVMTALPRYQDQGRPFMAFVYGIASHKVADAHRNAARNKADAMAEVPDVISTDQGPEQRALESETSRQMNSLLATLPEKHREILILRLVMGLSAEETAVAVGSTAGAIRVAQHRALAKLKSQVARAGEMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H946</accession>
    <name>A0A231H946_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inner membrane transport protein YdhP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydhP_2</name>
        <name evidence="8" type="ORF">B7C42_02475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45350">
        <property type="protein sequence ID" value="OXR45350"/>
        <property type="gene ID" value="B7C42_02475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="46"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="434" mass="43337" checksum="58B83BC7B4AC4D73" modified="2017-10-25" version="1">MADSASVRTAPPVDFPPESPASDVSSRAPLGSEGAPQTRTGWHIPAMLALALGGFGIGTTEFVTMGLLPDIAADLHVSEPTGGHAVSAYALGVVVGAPVIAALCARMPRKRLLIALMVAFTVGNIASVLAPAFPALVAARFVAGLPHGAYFGVASLAAASLAPVGQRAKAVAAVMLGLSAANVVGVPAATWLGQVLGWRDAYVVVAVIGVATVFAISRFVPDLHGVRVTDPRTELTALRRPQVLLTLLVGAVGFGGMFAVYTYITSTLTDVAGMGQGLVPIVLALFGLGMVAGNIGGGILADRGVDRSVFVALIAMVVILAGFVAAAHNPFTAAAGAFLVGASGAALAPGLQTRLMDVAHDAQTLAAALNHAALNIANAAGAWLGGLVIAAGLGYTAPAVVGAGLAVAGVVLFTITAWSARRVAAHREVAVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H976</accession>
    <name>A0A231H976_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776759.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45247">
        <property type="protein sequence ID" value="OXR45247"/>
        <property type="gene ID" value="B7C42_02372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="22103" checksum="B96D4EE9A578677B" modified="2017-10-25" version="1">MPPRDPEATKARIFEAATEEFAAHGIAGARVDRIARNAKANKQLIYAYFGDKQQLFEQVLEKAMIDVAAAVSTDIDDIDAWVDAHIAYHREHPEFLRLQMWEALELAPDQVTAGEARARRYRDKIEKVEAAQRRGLLRDDMPPGYLLTLLTGLINYQQALPQSRRFVVGGPDDPAELRNWVRDAARRIVAPREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9D1</accession>
    <name>A0A231H9D1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PspC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_02537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45412">
        <property type="protein sequence ID" value="OXR45412"/>
        <property type="gene ID" value="B7C42_02537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="7138" checksum="A64360BDD509E77B" modified="2017-10-25" version="1">MTAPTRRRTRSTSDKWIGGVCGGLAEYFGWNANVIRLLFVLSCLLPGPQFIVYLVLWLIIPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9F2</accession>
    <name>A0A231H9F2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776572.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45432">
        <property type="protein sequence ID" value="OXR45432"/>
        <property type="gene ID" value="B7C42_02557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="10841" checksum="642E669D299011BD" modified="2017-10-25" version="1">MGDFGQISYDFGTIDDAGTGIKSEAMNITAALEDMEKKFQDFITSHWTGSDAAHAFQSVQQNWRQQSDELSASLAQLGTHTVNSGEQMQGADVLAAKLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9N6</accession>
    <name>A0A231H9N6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85C</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpC_3</name>
        <name evidence="2" type="ORF">B7C42_02684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45559">
        <property type="protein sequence ID" value="OXR45559"/>
        <property type="gene ID" value="B7C42_02684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011257933" evidence="1">
        <location>
            <begin position="42"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="38015" checksum="BFCAC786D7A5171C" modified="2017-10-25" version="1">MRRYRYEGRIPRRRFRPRIGPVIAAVLAASALMTYPATGFADPVPSGSGGGASAIVGVRTDDARHQTVTVHSASMAKDIEVQVQRAADQATPRPVLYLLLGAGGGIDGATWASRTDALNFLADKNVNVVTPIGGQFSYYTDWKNDDPFLGRNKWRTFLTEELPPLLDKFLNANGRNGIAGYSMSATTTLALAALTPGLYSAVGSYSGCAQTSDPMGQEFVRLTVNTWGWSNTDNMWGPTGDPEWARNDPYVHAEGLRGKAIYIANGTGLPGPYDTYGGKYSLPGAWGFSNQIVIGGIIEAATNLCAHNMQTRLDSLGIPATYNFRPTGTHTWGYWQDDLEQSWPVLAEGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9S6</accession>
    <name>A0A231H9S6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">rpsE</name>
        <name evidence="12" type="ORF">B7C42_02621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776501.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45496">
        <property type="protein sequence ID" value="OXR45496"/>
        <property type="gene ID" value="B7C42_02621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR45496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="21968" checksum="1CE141A1F03FB30B" modified="2017-10-25" version="1">MPGRQRRDGGSGPAGQGGSGNERDQRGGGRDRRGGGDRRDNAAEKNQLERVVAINRVSKVVKGGRRFSFTALVIVGDGNGLVGVGYGKAKEVPAAIQKGVEEARKGFFRVPMIGSTITHPVQGEAAAGVVMLRPASPGTGVIAGGAARAVLECAGIHDILAKSLGSDNAINVVHATVAALKMLQRPEEVAARRGLPIEDVAPAGMLRARAGQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAD3</accession>
    <name>A0A231HAD3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45914">
        <property type="protein sequence ID" value="OXR45914"/>
        <property type="gene ID" value="B7C42_02206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="131"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="35137" checksum="57ECA4FD0E397E8F" modified="2017-10-25" version="1">MSARSPGAVLIVAESGDLHADAMASMLRNMYGLIPIRLDMRDFPRECGSFRLDRAGAARSMSHIAGLDDVTAVWWRRPRPCRVPGGFLDGDDDFRQAECDGFLQGLLWSIPAVWVNDPGADRTATRKIVQLDTARRSGFAIPETLITNDPDEARSFVDSRGGSVIYKRTGTGRAEFSETRIVSREDLGRFDTIRSAPTTFQDYVEAECDLRVVWIDGVEWAVRIDSQSGAGWVDSRLDTSVAFTRERLPASVSKSLTTLMGALGLVFGVLDIRLGLDGEYYFLEVNPQGQFAYLEIKTGLPIFASLAQFLVHGEAMVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAI6</accession>
    <name>A0A231HAI6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator SinR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sinR</name>
        <name evidence="2" type="ORF">B7C42_02137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783458.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45845">
        <property type="protein sequence ID" value="OXR45845"/>
        <property type="gene ID" value="B7C42_02137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="42736" checksum="8FD2F1E92774F497" modified="2017-10-25" version="1">MDLGERLQSLRKRRGLTQRELAELSGVSLSYIRKIEQGERTDARIDTLRRFAVTLGCSLTALLGPAPSAPESGGDSALWEPTRDALAAMRDSTVEESMPVGGVEAALADGTRLYHDNRYEALAHVLPRLIEDAQVASPLVRSRVLQLAGSALVQTRQLSAARIALDRSLADAESTGNVLDAASAVITLCWLLIVERQFDAVRRLATEWADRVEPRLSVATTREISTWGWLLLRGSAAAIRDNRPDEADDMMRLAAAGAVAVRPERAPYHQYWTTFDPPTVAMKRVENAVVADRPDLALRLARDIAPDPRPTSDNRNRHLLDVASAHLELRHYDAAFEVLTTLSREAQPWLVEQRMARDLLSRIIAKRRTLTMEMRGLAGLLKLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAM9</accession>
    <name>A0A231HAM9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent glucose-6-phosphate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd_2</name>
        <name evidence="2" type="ORF">B7C42_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45908">
        <property type="protein sequence ID" value="OXR45908"/>
        <property type="gene ID" value="B7C42_02200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052749">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase (coenzyme F420) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="317" mass="34507" checksum="64825BA6444078E6" modified="2017-10-25" version="1">MAAIGYFLASEQFGPKELVEQAQRAEQAGFERLWISDHFHPWNDAQGHSPFVWGTIGALSQVTSLPITTAVTCPTVRIHPAIIAQAAATAAVQLDGRFVLGVGSGEALNEHIFGDPWPPPGERLQMLAEAVELIRRLHRGDMVTYRGEHYDVQEARIYTLPEQPVPIYVSGFGPQATELAARIGDGYCTASPDAELIGLFRDSGGGAKPVQMGTKVSWAADEESGVDAAHRLWANELLPGWLGQTLPRPADFEDAMSLLDREASRQHFAAGPDPQRHIDQVRTCVDAGADEVYVGQIGPDLEGFFTAYEKEVLPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB54</accession>
    <name>A0A231HB54_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-succinylhomoserine sulfhydrylase</fullName>
            <shortName evidence="3">OSH sulfhydrylase</shortName>
            <shortName evidence="3">OSHS sulfhydrylase</shortName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">metZ</name>
        <name evidence="6" type="ORF">B7C42_01064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:27826"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family. MetZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781388.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46100">
        <property type="protein sequence ID" value="OXR46100"/>
        <property type="gene ID" value="B7C42_01064"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071268">
        <property type="term" value="P:homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02056">
        <property type="entry name" value="MetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006234">
        <property type="entry name" value="O-succ-hSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01325">
        <property type="entry name" value="O_suc_HS_sulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="43165" checksum="6D3A0C8B77F58CF4" modified="2017-10-25" version="1">MITGGAFDRPLPEGVGPATLGVRGGLRRSGFEETSEALYLSSGFVYESAEAAEAAFTGDIEHFVYSRYGNPTVAMFEERMRLLEGAEACFATASGMSAVFTALAALLGQGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLGQWERALSQPTAAVFFETPSNPMQTLVDVRRVSELAHAAGAKVVLDNVFATPLLQRSLDLGADVVVYSGTKHIDGQGRVLGGAILGTSDYINGPVKNLMRHTGPALSPFNAWTLLKGLETMPLRVRQSTQSALAVAEFLERHPGVAWTKYPFLTSHPQHELATSQMSGGGTVVTFELVAGADEGKKRAFEVLNRLRIIDISNNLGDAKTLITHPATTTHRAMGPEGRAAVGLTDGVLRISIGLEDVEDLLGDLEQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBD3</accession>
    <name>A0A231HBD3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46171">
        <property type="protein sequence ID" value="OXR46171"/>
        <property type="gene ID" value="B7C42_01136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="16299" checksum="9AF458C85D62B9FD" modified="2017-10-25" version="1">MAFRKSTIQKQLAEKLAEFAPPGEQMQLAFQAITGPSPWVDDLPYVRFAMLFVRKYYFVVLTNTSVVIVEANKWSGRPASLVCAEHFSTAVFTEMKINPLWSKVYYRMPHTGAPERLNVHRRWREELDALVSRLPQLANLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBH3</accession>
    <name>A0A231HBH3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetolactate synthase</fullName>
            <ecNumber evidence="5">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ilvB</name>
        <name evidence="14" type="ORF">B7C42_01260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781586.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46294">
        <property type="protein sequence ID" value="OXR46294"/>
        <property type="gene ID" value="B7C42_01260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_N" evidence="13">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="11">
        <location>
            <begin position="194"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="12">
        <location>
            <begin position="385"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR46294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="561" mass="58711" checksum="89FC29E0C58B41ED" modified="2017-10-25" version="1">MPTRVVDYLVQAVSDMGVRHIFGVDGANIEDLYDAAYDAADRITAVVAKHEFAAATMADGYARATAGFGVVCATSGGGAMNLIAGLAESHASRIPVLALVGQAPTDLEGRGAFQDSSGRAGTFDAAELFDTISLYCARVETPASLPAHLSRAVAAARAGGPAVLLLPKDVQQAELDAGPFVAPRPVHGRDDAGIERLLEGLRAARVVGKVVIIAGAQVARDDARDELRDLAAVLDAGVGVAPDAKDVYDCTEHGFLGVAGSMGHTELADALRGCALCLLVGTRMPVTARAGLESVLGASTASVGGEPPYLPAVHATSTDLAATLRELTSALTTGAGRVHRVEPRRPRRAPDPLPVPPADGPGLRYRDIVETLNATVHSDTDVFADAGNTGASVVHHLRPPRDGRFVVALGMGGMGYAFGAAIGSCFARRHRDDGTERRTVVVAGDGAFYMHGMEIHTAIQYGLPVTFVVLDNSAHGMCVTREQLFYGDRYSFNRFHKAHLGAGMAAMFPDLPAFSPATPAELTTVLSYCLETPGPSFVSIDCDPDEIPPFIPFLSASRRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBP7</accession>
    <name>A0A231HBP7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroQ</name>
        <name evidence="11" type="ORF">B7C42_01244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781576.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46278">
        <property type="protein sequence ID" value="OXR46278"/>
        <property type="gene ID" value="B7C42_01244"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15356" checksum="5B00EEBCC0134AE2" modified="2017-10-25" version="1">MAPILVLNGPNLNMLGTRQPEVYGSDTLDDVVELCRQTAARFDREITAYQSNSEGALIDRIHAARGVEAGIVINPGGLTHTSVALRDALVIPEVPIVEVHISNVHAREEFRHHSYISPIATAVIAGMGIRGYAAAIEFLCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCF5</accession>
    <name>A0A231HCF5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phthiocerol synthesis polyketide synthase type I PpsA</fullName>
            <ecNumber evidence="7">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppsA_2</name>
        <name evidence="7" type="ORF">B7C42_01552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46581">
        <property type="protein sequence ID" value="OXR46581"/>
        <property type="gene ID" value="B7C42_01552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="53"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1244"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1387"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1797" mass="189096" checksum="60F71112A592AB77" modified="2017-10-25" version="1">MADNEGTQTTETSGVTAAETTGDANAEVEQTTATGQSVTEPGGVAKSGGTTDMSVAELREWLQRWVADATGQPVEQITVDRPMEEFGLASRDAIALGGDIEELTGVLLNATIVYQHPTIAALAERIINGEPETPEEAADDAFYTAGYQPGAAHDIAIVGLSTRLPGAGDTPESTWDFLINRGDGIRDLPEGRWSEFLADPDIAAAVENGNTLGGYLDQDVIKGFDAEFFAMSPVEVERVDPQQRLMMELTWEALEHARIPANTLKGESVGVFIGTSTNDFSLIAALGLGKSDTDAPASADAYALTGGSTAIVANRVSYFYDFRGPSVAVDTACSSTLVAVHDAVRALRNGDADVALAGGVNMLLAPAITLGFDSIGAVAKDGHIKAFSSDADGMVRSEGAGMVVLKRLADAERDGDRILAVVKGTAVNSDGRSNGIVAPNPDAQVDVLRRAYRDAGIAPSTVDYIEAHGTGTPIGDPIEADALGRVIGRGREDDKPVLLGSAKTNFGHLESGAGAAALAKVILALQHNVIPPNIGYAGPSPFIPFDQAHLKVVDEPTEFPRYSGTATIGVSGFGFGGTNAHVVIQEYVPAAAAEAKDAAAQGASADAETLDAELDNEATDVLAGAEAIVEGSDPLAAPEPVAEVAEWTQERTEPLPVILPVSAYLPSRRRRAASDLADWLESEAGQATPLEDVARSLAKRNHGRSRGVVLAKTHEEAVAGLRAIAAGKPGAGVFTADSPAAQGPMWVLAGFGSHHRKMGKQLYLENSIFARTVDEVDELVVDEAGYSVKEMILDDAQDWDVGTSQVGVFTIQLGLAALLRAHGAEPHGVVGHSQGEAAGAYISGGLPLEDAVRVICARSRLMGEGEQMITDDQVRNMALVEYSAEDIEKVLPEYPDLEVAVYAAPTNTVIGGPPDQVHAIVARAEAEGKFARVLQTRGAGHTSQMDPLLGELAAELAGIEPTKVTTDLYSTVHKATVYKTGSDPVHDVDYWVTNMRGSVYFTNAIRRAVDAGITTYLELAPNSVALMQVMGTTFAAGVHNAALIPTLKRKEDEAAGVISALAQLYVQGHPVDLVSLLPAGDYADVPRTAFLRKEYWPKVSIATGSGTGRAPGAHVALPDGRHAWEVSAAAVTDLAGLVNAAAAQVLSEVALGATVAHSPLPASGTLTTTLTPHPGGASVQVHVREGTAFRLLFDAVVTASAPSTNGTPAPAVQPAPAPAETGSGTADLVVAESFGDRWDPNGTQTVEERLATIAAESMGYAVEDLPMEIPLMELGLDSLMAMRIKNRVEYEFDIPSLQVSAVRDASLNEVGKVLRYAIEHRDEVAAMAEKQAAEGGSLTVDDNFVAAARAAMEAGEDPAAVVQQQVAAAPAGTAGAVADVADADQKASATADSASEVAEPAGGGADAKDGAATAQAAAVFGGGQGAGTKEPESDVPPRDAAERLTFAAWAMVTGKSAGGIFNTLPILDEDTAEKLAARLSDRVGSTVDVDDVLDCETIEQLSDIIRRHQDSATEVEGFIRPLRPRPEGSTAIPIFVFHPSGGNTLVYEPLLKRLPEGTPMYGFERIEGSIPERAREYAAEIRKIFPSGPYVLYGWSLGAVFALQVAQIMRAEGDDVRLVGLIDLAIPVEDEDSSPEGRRARIERFQAFAQKTYGIEGQLDDEMLQELADASDEEQYEIIMSLLKFADVKIPGGVLEHQRTSWLDGRDLQKAQPSHYEGDVTLYLADRYHDGIIELEPRFADRQPNGGWDGYIPNLEVIHIPGDHLQIIDEPRVAQIGADLTRKLAAISDDAPGKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCW4</accession>
    <name>A0A231HCW4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063006997.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46615">
        <property type="protein sequence ID" value="OXR46615"/>
        <property type="gene ID" value="B7C42_01586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="33873" checksum="2FD92B1E08BA5C90" modified="2017-10-25" version="1">MYAATLDGFGGPEVIRWAEVPDLPPPGPGEVAIDVVAAGVNRADLLQRQGFYPPPPGASDILGLEVSGVVAEAGAGVRDPRPGDRVCALLSGGGYAQRVVVAASQVLPVPEGLDLAAAAALPEVAATVWSNLVMRAGLHAGQLLLVHGGGSGIGTHAIQVAVNRGARVAVTAGSQYKLDRCAELGASIGINYREQDFVEVLGESGGADIILDNMGAKYLPRNVSALAEDGQLCVIGMQGGVTGELNLAELLGKRGTIHATNLRKRPATGKSSKAEIIAELRRHLWPLIAEGAVVPVVHAEVPVTEAAHAHELLDSAETVGKVVLRIDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD52</accession>
    <name>A0A231HD52_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775335.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46732">
        <property type="protein sequence ID" value="OXR46732"/>
        <property type="gene ID" value="B7C42_01709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="27867" checksum="9F830B392EEE7CE3" modified="2017-10-25" version="1">MSETQETTPTGESGRPAVEHAAFAQAAGGPFTLIVTLFTATLMISNICATKGVQFFTGHEVSLGPIEILPITTDGAFFLFPLAYVIGDVLSEVYGFKAARRTIYYGFGMLILMVVCFWIAIGLPAAGFYENQDAFRTVAGTTPQLVAAGLAGYVVGQFLNSMTLVLIKERTKEKHLWARLLGSTVAGEFGDTLVFCSIAATAIGINTWGAFINYVIIGFVWKTLCEVLIMPISYRCIAYLKKHEPSYAPLDKPALYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD62</accession>
    <name>A0A231HD62_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775343.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46736">
        <property type="protein sequence ID" value="OXR46736"/>
        <property type="gene ID" value="B7C42_01713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7174" checksum="89BF610516E7246B" modified="2017-10-25" version="1">MKVDSAGAVWRKSKYSGPDGNCVEVAFLGDGNVGVRDTKDRGRGPILAFTPGEWDAFVSGVTDGKLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDW6</accession>
    <name>A0A231HDW6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Quaternary ammonium compound-resistance protein SugE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sugE_1</name>
        <name evidence="8" type="ORF">B7C42_00252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47130">
        <property type="protein sequence ID" value="OXR47130"/>
        <property type="gene ID" value="B7C42_00252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="10710" checksum="5078F7828DCB720F" modified="2017-10-25" version="1">MAWIVLVLSGVFEAVWATALGKSHGFTRIVPSLIFAAALVASMSGLAYAMRTLPVGTSYAVWVGIGAALTVVYAMMTGTEQASLVKIVLLLLIVAGVVGLKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HED6</accession>
    <name>A0A231HED6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddn_1</name>
        <name evidence="3" type="ORF">B7C42_00466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47343">
        <property type="protein sequence ID" value="OXR47343"/>
        <property type="gene ID" value="B7C42_00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="164" mass="18213" checksum="FD617D2D88BB8946" modified="2017-10-25" version="1">MLGGMPWLAGIVSATTRFANRRGVYAGRRATKVHVALYRRSGGRIGGRMPGRRRARILLLDHLGAKSGIVRTSPLLYVDVGAAVAIAASKAGQPHHPAWYHNLLAHPDTTIRIGTEVRPVRARVATVAEYPALRREFVTMTPDYEFYRRQAGERRIPLVVLDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEF9</accession>
    <name>A0A231HEF9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_00280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47158">
        <property type="protein sequence ID" value="OXR47158"/>
        <property type="gene ID" value="B7C42_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="21892" checksum="DFD57A317432A4D5" modified="2017-10-25" version="1">MDPNESPGPDGEPSAIDLAILAAGRACVEEFGVRRTTLSEVARRAGVSRPTVYRRWPDTRSLIAELLVRELSEIVATSIPTEGPARARLVEGIVSGAAELRSNPLFAKIFRIDTDLMLTYVFGRLGRNQRQLIQVFSSAVREGQRDGSIRAGDPDHLATMLLLIGQSTVQSAGTVSHLLDDAGLDVELARVVDRYLRPDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF50</accession>
    <name>A0A231HF50_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Caffeine dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="2">1.17.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdhA</name>
        <name evidence="2" type="ORF">B7C42_00469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.5.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47346">
        <property type="protein sequence ID" value="OXR47346"/>
        <property type="gene ID" value="B7C42_00469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034875">
        <property type="term" value="F:caffeine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="783" mass="82482" checksum="20BEE91774865FE1" modified="2017-10-25" version="1">MTSTTTTASASVVGARVPRIEDARLVTGAGTFVDDVTRPGVGHACFVRSPLPRATIGTIDVSAALELDGVLAVYTAADLNPGAHEISYDLDMVGMPPVPRPPLAEEEVRFVGDPVALVIAADRYIAEDAAELVVVDYEPLDPVVDYTTADQSPNLVHAGFAGNSAGAMGGRPASDLAPLFDSAAHVVRQQIFQQAYLPVPMETRGILAEWTASTAEMTIWIATQSPHEVRAFCARLLGTDEHQVRVIARDTGGGFGLKQLPLREETCVMLASRALGTPVKWIEDRQENLMASGLARHENADVAMAFDADGRIVAASIDHVQNVGAYPTPSPITGGVVVGILFPGPYRITDASFSAKFLYSNTVGRVAYRGPWQFESVAREVLLDHAARRIGIDPIELRRRNMLRRDELPWANPNGMSYDNISPLETLEQAVEKLDYDAFRADQRAARAQGRYLGVGTCTYVEPTTGASPFLSTEGATIRIEPSGKVNVYVAGGSAGNSLETTVVQLAADALGVTLPDVRTIQGDTAVTPFGGGTGGSRSGSMTAGAIGQTAAVLRERIVAIAAHRLGVAPEEIDIADSRASVRGAPDKGLTLAEIADIAYFQADSLPPGVPPGLEASGRHKTSQMAIWANATHLCTCEVDIETGAVTLLRYIVSEDVGPMINPNVVEGQIYGGTVQGIGGALYEHLAYDESGNPVATTFLDYLLPTAMEVPVIEVGHVETPSPGPGSFKGVGEGGAIGAAPAVLNAVADALSPFGIELRELPLSPARIVDMVERARATGKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF72</accession>
    <name>A0A231HF72_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">B7C42_00647</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47522">
        <property type="protein sequence ID" value="OXR47522"/>
        <property type="gene ID" value="B7C42_00647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="36"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="147"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR47522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="26526" checksum="106A3E0DE352D505" modified="2017-10-25" version="1">MATGADEPAQRSSALRIDVVTIFPEYLEPLRTALLGKAIEKGIVELDVHNLRRWTHDVHQSVDDAPYGGGPGMVMKPVVWGDALDEVCPDEALLVVPTPAGVPFTQATAQRWSAESHLVFACGRYEGIDQRVFDDAARRVRVEEVSIGDYVLIGGEAAVLVMAEAVVRLIPGVLGNQASHQQDSFSDGLLEGPSYTRPVSWRGLEVPEILLSGNHARIEAWRHEQAVRRTRERRPDLLPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG08</accession>
    <name>A0A231HG08_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysG_1</name>
        <name evidence="9" type="ORF">B7C42_00750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47625">
        <property type="protein sequence ID" value="OXR47625"/>
        <property type="gene ID" value="B7C42_00750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012409">
        <property type="entry name" value="Sirohaem_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036426">
        <property type="entry name" value="Sirohaem_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="173"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="419" mass="43507" checksum="8FB3BFCB41FAC89F" modified="2017-10-25" version="1">MPNTTDDQQSGDPNYVVGLDLAGRRVVVVGGGSVAQRRLGLLIASGADIEVISRTVTPAVEGMATSGQLRISQRAYADGDLDGAWYAIACTDEPETNAAVVEEATRRRIFCVRADNARLGTAVTPASARYDGLTLAVLASGRHRRSAAVRTALLEALQSGVVTDDSEPVAPGVALVGGGPGDPDLITVRGRRLLARADLVVADRLAPPELLAELGPHVEVVDAAKIPYGRAMAQEAINTALIEGAKAGKFVVRLKGGDPYVFGRGYEELEACVDAGVPVTVVPGVTSAISVPALAGIPVTHRGVTHEFVVVSGHIPPDHPDSLVDWPALARLRGTLVLLMGVERVEKFAAALVDGGRAADTPVTVVQEGSLRTQRIVRADLSTVAERVRAEGIRPPAIIVIGPTAGFTAGAPDVDEQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSG9</accession>
    <name>A0A231GSG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000338">
        <property type="protein sequence ID" value="OXR39573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39573">
        <property type="protein sequence ID" value="OXR39573"/>
        <property type="gene ID" value="B7C42_08359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="40" mass="4400" checksum="4D6E1100DD2723A1" modified="2017-10-25" version="1">MPDWERELLEGDGAKTEAKAEEPKAEAKKADEAPEAEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSK5</accession>
    <name>A0A231GSK5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000340">
        <property type="protein sequence ID" value="OXR39572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39572">
        <property type="protein sequence ID" value="OXR39572"/>
        <property type="gene ID" value="B7C42_08360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850520" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="7186" checksum="B7E3D8986B0674C0" modified="2017-10-25" version="1">MYGSGSPACLASAATRATSASAARALANSSSISRAASGTLSNTNASDGVNFTPVPAPTFDRSTPLALAKPAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSK6</accession>
    <name>A0A231GSK6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgC_2</name>
        <name evidence="7" type="ORF">B7C42_08333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000180">
        <property type="protein sequence ID" value="OXR39599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39599">
        <property type="protein sequence ID" value="OXR39599"/>
        <property type="gene ID" value="B7C42_08333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR39599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12894" checksum="1B77E47E6A6B480A" modified="2017-10-25" version="1">MLSNLVNAGYLRLCVLTQYKSHSLDRHISQTWRLSGFAGEYITPVPAQQRLGPRWYTGSADAIMQSLNLIYDEDPDYIVVFGADHVYRMDPEQMVSHHIDSGAGVTVAGIRVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSU8</accession>
    <name>A0A231GSU8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000098">
        <property type="protein sequence ID" value="OXR39658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39658">
        <property type="protein sequence ID" value="OXR39658"/>
        <property type="gene ID" value="B7C42_08273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="37944" checksum="6E5EC3F33C31D561" modified="2017-10-25" version="1">MEHNRRARPTIRLLSEDLPSGWEDPNCTRAIADRQWDRLRPLAELPHPLLRKAAEMYGPDPVHDPAPRPIERLGSFRLQELRNSQWRAGIWTDPETGVRWIVAAGLAKGGHQDGDDFYKTLERRVGNEGGASSMLPTARDVELLKTETAAWALTSWYLEIQTRITQALKDIRAIGCIRVDLPPSPRRQSSTIGQVEIDFEAISDDETPREEFTVTFRLDAAHLTSNWGWRAIQRVLISIAPPVQDWDRHQNIAFVMGDPGHLDRQLRHLSVANEQSVLLAAEHGAVSHYTHAPHIAEASVTGTALRAMCGVVFVPTRDPDRFPVCARCEEEYAALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSY0</accession>
    <name>A0A231GSY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000281">
        <property type="protein sequence ID" value="OXR39581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39581">
        <property type="protein sequence ID" value="OXR39581"/>
        <property type="gene ID" value="B7C42_08351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="8614" checksum="5FF626323A5B8F49" modified="2017-10-25" version="1">MSSSSSPAVTRCLRWAAVAGSGVPVFADRGARTAGRAASANSGACATSGTAPCDQRSSSDNACLHGTLRLGQSHRYDGPDTSTTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTQ0</accession>
    <name>A0A231GTQ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dapA_4</name>
        <name evidence="9" type="synonym">dapA</name>
        <name evidence="12" type="ORF">B7C42_07965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39958">
        <property type="protein sequence ID" value="OXR39958"/>
        <property type="gene ID" value="B7C42_07965"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR39958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="31802" checksum="BD3D318B16BF9EDB" modified="2017-10-25" version="1">MIMVETPFGRVITAMVTPMHADGSIDYDGLQNLAVYLADHGHDGLLVNGTTGESATTTDGEDYACVRAVVEAVGDRVQVMAGCGTNDTEHSTRAAREMVACGADSLLVVTPYYNKPPQDCILEHFRLVAEAGGGVPVMLYDIPGRTGTALSTDTIRHAADIPAVRAVKDAKGDFFEASRLMSQTDLLWYSGDDVVNLPHLAQGATGIVSVVGHVAGDLYAEMIAAVDRGDLPRAREIHRRLIPAVDAIMHVSQGAIQAKAAMKMLGVISSDALRMPYRQGPPEHQQRLRAGLEESGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTR4</accession>
    <name>A0A231GTR4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782732.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40014">
        <property type="protein sequence ID" value="OXR40014"/>
        <property type="gene ID" value="B7C42_07898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="33761" checksum="393C25D2E9404ABF" modified="2017-10-25" version="1">MMARNTFLAGESGVAVPDRWQMKLLAGVYTHASAAREMAAAARAGREATGEFPPPSWSRAFRTEVLLGQELEKAGLAAGVPCEWLNQARTRAHLAQPWRRDLHWRIPKPVDRARLLVGLAGEAHRIQDLAAVAVAYEHRGAHAEPGTATWVMRNLRRSRTRVVQLARLLAVTDDEAQRMWNSPQHWTAAAEGARAATVDELDARWREHARSDQTSVVLQARALTKSGITAPTSAALPPPDQILQLLRNKLGHTTVPVSEASDRRLAADLVAPAGQGIDRAVAAAGIGSSGHDGLVADLAPLPRQPGTGVEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUG6</accession>
    <name>A0A231GUG6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40232">
        <property type="protein sequence ID" value="OXR40232"/>
        <property type="gene ID" value="B7C42_07657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005587">
        <property type="entry name" value="UPF0304_YfbU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023146">
        <property type="entry name" value="YfbU_alpha-helical_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023145">
        <property type="entry name" value="YfbU_helix-hairpin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03887">
        <property type="entry name" value="YfbU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="27853" checksum="5238F7D31B656973" modified="2017-10-25" version="1">MAPLTLRVDDTTREELEALARTKGTNVSELLREQIGQLLGRDVKMRRGDVPASLTMTERLILSQQAKIMAALDPDEAEYHLRRSEVLDEGYAGEYGEVFGSIGPELTRTECQLLWDILDMFRVLGASIDKLSQEDRKVLEEDGHIDMLRFRGFDLADELEGRLLSYTRYLTRTERWEEIIPRLEEIGDKGDAHWRWLPCYRAMLETFQPIFAGRQKNRGYGRDALYLSLDELIEVAEVKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV39</accession>
    <name>A0A231GV39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40466">
        <property type="protein sequence ID" value="OXR40466"/>
        <property type="gene ID" value="B7C42_07404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="7050" checksum="D2438E26C326C081" modified="2017-10-25" version="1">MLYTFETATQYVIAELEAKGTATREDFDVPAIVATSHAIAESWDFQALDRHTFWSIAASNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWG3</accession>
    <name>A0A231GWG3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779415.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40967">
        <property type="protein sequence ID" value="OXR40967"/>
        <property type="gene ID" value="B7C42_06933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="95"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="23621" checksum="898E28D0A2E8DDFD" modified="2017-10-25" version="1">MVSLITEGSAVDDKGRPFLRRRYQPWVALIAVLALICAIVWIKALTTADTTHTAMACNSPAPAAPDPNSPQPAPLGDVVSPSRLHDVEPAPLAQAKVRVLNGSGQRGLAEHIASKLGDYGFASPPAPVFGNDPVYLSGDLVCTGQIRYGVSGRPAAAAVQLVAPCAELIEDQRTDDTVDLALGTLFGNDLQPSTDAEEVLRALKNPAPNGPDVDSALLQAARTARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX33</accession>
    <name>A0A231GX33_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH oxidase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41071">
        <property type="protein sequence ID" value="OXR41071"/>
        <property type="gene ID" value="B7C42_06841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="17"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="375" mass="40103" checksum="326267CD47FD37F7" modified="2017-10-25" version="1">MPVTASDVSRAAEILSRPVSLNSLTIPNRIVMAPMTRMFSPGGIPGDDVRSYYARRAAAGVGLIVTEGTYVGHESAGQSDRVPRFHGAEQLAGWAKVAADVHAAGGTIVPQLWHIGMVRNHGEQPYPEAPAMGPSGIRVDGTEGAGEAMTQRDLDDVVAAFAEAAAAAERIGFDGVELHGAHGYLIDQFLWARTNRRTDAYGGDPSARTRFATEIVAAVRAAVSPGFPVIFRFSQWKQEAYDARLAETPQELDAILAPLAAAGVDAFHASTRRYWLPEFEGSDLNLAGWTRKLTGKPTITVGSVGLDGDFLHAFTGRGAELGSLDNLLDRLERDEFDLVAVGRALLQDPEWAAKVLGGRIDELKAYDAAALKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX64</accession>
    <name>A0A231GX64_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative oxidoreductase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_06608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41210">
        <property type="protein sequence ID" value="OXR41210"/>
        <property type="gene ID" value="B7C42_06608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="6">
        <location>
            <begin position="132"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="7">
        <location>
            <begin position="658"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="773" mass="85302" checksum="DC49E746AFB5C4D2" modified="2017-10-25" version="1">MAIDFTDRSGADTGPSGAKDADAVPSFHPYDHPAAGWGAARAVTEFMIGREKEPILGPRAIMKMNHENGGFDCPGCAWPDSLKGIHLDICENGIKHVTWEMTHKRVGREFFAAHTVGELSGWSDHDLEDQGRLTEPMSYDPDTDTYVPISWPEAFELVGRTLRELDDPNQAAFYTSGRLGNEATFLYQLLARELGTNNLPDCSNMCHEASGRALQAAIGTGKGTCDLEDWERADALFIMGVNAASNAPRMLTALAEADRRGAQIVHINPLIEAGSRRTIIPHEFLQMATFHSTPVGTMKLQTRIGGDFAVLRGMAKAVLEQARTDPKALDQDFIDRYTTGFDAYRAQVEATPWPLIEQQSGLTEVEIRRAAGIYCDADRSVISWCLGVTQHEHGVDTVREIVNLLLLRGNLGREGAGPSPVRGHSNVQGNRTCGIDHRPAPEFLDRLARVCGIDPPRAHGLDTVATIEAMQAGSVRVFLGMGGNFALAAPDTAYTFAALRNCELTVHVSTKLNRSHLVHGARALILPCLGRTERDEQRGGLQQTSVEDSMAMVHLSKGMKKPASPHLLSEPAIIAGIAKAALPHSNTPWDYYVEDYDRIRDTMARVLVGFEDFNRRVRLPLGFRIRQPARELIFLTPSGKAEFSTADLPDLTCEPGTLTLATMRSHDQWNTTIYSDNDRYRGVKNLRTLVFMNEHDMRERGLALFDEVDITSIARDGSTRKVQRYKVIPYDIPRGCAAGYMPELNVLCAIGDYSTQSDQPIMKNLKVTIEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXC6</accession>
    <name>A0A231GXC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41274">
        <property type="protein sequence ID" value="OXR41274"/>
        <property type="gene ID" value="B7C42_06672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="22012" checksum="AF49F52F6B16DD94" modified="2017-10-25" version="1">MATATDQADTKLRSDDPATEDTEPGADSSSVAVAEEATQASADVKTARRLPVTAIGVVLLVVAIIAGSVVATFMQLHLRADDAAKDRDAAVVSAARRMVVDLTTLSQGSLDGDMKRIMSETTGSFRDQFSHQADSFRQVVAKGAVESTGQVTEAGLISADDNQAQVLVASTSTVKNSDAPNGQQRLYRMKVSLQHLGGTWLVSDVEFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXI5</accession>
    <name>A0A231GXI5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41337">
        <property type="protein sequence ID" value="OXR41337"/>
        <property type="gene ID" value="B7C42_06480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="552" mass="57770" checksum="A347DDC9C1A23275" modified="2017-10-25" version="1">MTTATLDRPHGGFAESFTRAANFTGTGQLLRLYLRRDRIVLPLWVLLFSAPLGSVYVSSVKNLYSSPADLQNFAHTILSSPAQLALYGPIYNTTLGAAGVWKAGMFYTLIGIATILTVIRHTRAEEETGREELLASTRVGRFAALSATLLLTCAACVVVGIVATLSIASSGVPFNGSLAFGAALAASGIVFAAVAAVTAQLSASARLARGIALAVLAVTFTLRAIGDARAGDGPTDILTWLAPQGWSLQVRPFAGDHWWVLLLHAVTTVVLVAVAYTLLRRRDMGAGLIADRPGPTAGSALLSGPLGLAWRLQRGTLVAWTVGLALYGLVIGSVVHGIGDEIGSSQTVRDIIARLGGSQGVEQAFLNTAFSMVGLGAAAFSISAALRMYAEESDDRAETVLTGAVGRIRWAASHLIFAFGGPVVALFVSGAVGGLAYGIAASDMGAKFPEALGAAMIQIPAVWVFTAITVLLFGLLPRWTPVAWGVFTAGVAIYLLGSISGMPQWVLDLNPYGHLPKLPAEDFRAMPVIVLLVLAAVITAVGLAGWRRRDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXJ7</accession>
    <name>A0A231GXJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator MprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mprA_3</name>
        <name evidence="6" type="ORF">B7C42_06506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41363">
        <property type="protein sequence ID" value="OXR41363"/>
        <property type="gene ID" value="B7C42_06506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="25040" checksum="4FB285A4284B89E6" modified="2017-10-25" version="1">MRVQPGRILLIEDADAIRTAVAAAVHAAGHEVLAREHGDRLESDLERFRPDVVVLDVMLPGRDGFGLLEVVRARSGAGVVMLTARDGVEDRVRGLRSGSDDYVVKPFDLAELTARIEALLRRMGRMHSRITIADLVLETDSGAVLRGSEPISLTATEFKLLAYLAAHRDRVVTKTQILTAVWGYEDYDPNLVEVYVSAVRRKLEEHGPRLLHTVRGMGYALRANPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXV2</accession>
    <name>A0A231GXV2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780404.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41402">
        <property type="protein sequence ID" value="OXR41402"/>
        <property type="gene ID" value="B7C42_06545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23060" checksum="E6053ACF1B90A188" modified="2017-10-25" version="1">MIYPDRRSAGRTLGESLSHLRAWHPLVLGLPRGGVPVAAAVREVIGGDLDVLLVRKLGVPWQPELAMGAIGEDGVRVLNEDVLRQTGVRAEQIAAVEEAERAELSRRQRMVRAQVPRVPIGDRTVVIVDDGMATGATVAAACRVARSHGPRWITVAVPVSSIEAMERLRGLARETVCPLIPRSLGGVGGAYRDFHQLDDEEMLDLLPTAHQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY62</accession>
    <name>A0A231GY62_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41564">
        <property type="protein sequence ID" value="OXR41564"/>
        <property type="gene ID" value="B7C42_06457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011245247" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="362" mass="37501" checksum="9CA7A9FECD89BB63" modified="2017-10-25" version="1">MNLPRPPRPVRACRIRWVWRIVPLTLAAALSAGCGLDPGSVPVPGTGVSGDTYHVHIQFANALNLPARAKVMSGGVRVGSLTAVRVTNPGVDTPGMAVADVEIQRSVRLSSATTAQLRQNTLLGDIYIELSTPAGVSGHAVRDDGVIPLAQSKPALQVEDILSGVATFTGSGAVGQFQDIVAQVNAAMPSDPAETSRIAGVVGVDLTDVAANLDSLSSLGDGIRADIQAMQDNAARLTDLLTPESATQVTAASASVVQLLGVIGGLGGIAHSIEWLAPLAASGDVAAQAFVPLVFSSRPFDLHAPSNLNRLVALLRDTIIPFFEHGPKVNVTGIDRADAPALPADQQVGRILDTLRMIGMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYC1</accession>
    <name>A0A231GYC1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41623">
        <property type="protein sequence ID" value="OXR41623"/>
        <property type="gene ID" value="B7C42_06264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="189" mass="20706" checksum="CC6D11B41871B1A2" modified="2017-10-25" version="1">MDPSAPQPSTAALLSDAQIEQLSLAQRLELVARLRPDRVRPDPRRVRVARGLRLSLMVGGSVAMIPWLVYLGLTLPQEYNANNWSLVWIGFDILLVVMMTTTAYLGWRRRALLILPAFGTGVLLLADAWFDTTTAGPDDIGVSIATAALAEVPLAVLLLTGALALFRYLVLANPLHDPAESPWRARLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYF6</accession>
    <name>A0A231GYF6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">pH-sensitive adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41561">
        <property type="protein sequence ID" value="OXR41561"/>
        <property type="gene ID" value="B7C42_06454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="34208" checksum="5D3F093B176394A9" modified="2017-10-25" version="1">MVDAVVETTLLGGPRRYTRAQVAELSGVSVETARKLWIALGFPAAASEDETAFTDADVAAVRTFCALGPASNVNEQNQIAAARTVGQSMARLAEWQADLITRELGAGTDAEATAHAIEVLTDLQQYAWRRHLAAALTRSLESDGAARQLLVGFADMAGYTRLSRHLDPDELTDLLEAFETATTEAITAHGGWVIKNVGDEVMFAVDDPHRGARIALDLHVAIARAAQRISEMPQIRVGLAYGPVLTRFGDLYGTVVNTAARLTGVARPGTVLVDDGAAAALAEDKEYSLRHLRSVRVKGFSRLRSHVLRERQRKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYL3</accession>
    <name>A0A231GYL3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_06338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41697">
        <property type="protein sequence ID" value="OXR41697"/>
        <property type="gene ID" value="B7C42_06338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="44076" checksum="41BEE795ACABA0A8" modified="2017-10-25" version="1">MTVPLLAWAGALALIVVLLVFDFVFHVRGAHSPTLRESAVWSAAYIGVAIAFGLVVWGLGGSEMGVEYFAGYITEKALSVDNLFVFLVIFTAFRVPAAAQQKVLLVGIVISLVARTGFIFLGATLINRFAWVFYLFGGVLLVTAGNMLRPESEDTHSGDGFVVRATRKLLRTTDFYDGDAMTTVVDGRRRLTPMMSAMIAIGGTDVLFALDSIPAIFGLTQNVFLVFTATAFSLLGLRQLFFLLEGLLDRLIYLGFGLAAVLGFIGVKLILHALHHNSVPFVNDGDPVPVAEIPTGWSLVVIVAILVVTVVVSLWSPAGRAQTAVAGARRYATRYLDLGYEADQAVRERTYARMLDSERVMAGLPDKYVHRFRADDLPTLLDRAHVVHEDRMNRIRAGLPLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYP9</accession>
    <name>A0A231GYP9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41702">
        <property type="protein sequence ID" value="OXR41702"/>
        <property type="gene ID" value="B7C42_06044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="216" mass="24287" checksum="D0AD9E2FC4E442C6" modified="2017-10-25" version="1">MQGHSGKARTMGSRAAAQQACRNPGERPFAGLCFVSRHPCAFGRREWRAGRTHSSSRSARRRDHTRGHSRARSPAATWFHPASRRTVLPIRGLRPRPGPCRAPRTAGQSLVGIRGRSAWRREHQRRPLAGRRPASAHPAHRPARARGLAVADPRHDHRNTPRCRRSPARAPRPHPHAPEQADARRRADHHEPAHRVGDFCPGGRPLAGYRAYRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZS6</accession>
    <name>A0A231GZS6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782902.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42114">
        <property type="protein sequence ID" value="OXR42114"/>
        <property type="gene ID" value="B7C42_05713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="151" mass="16559" checksum="F7D0ED287D3CE48B" modified="2017-10-25" version="1">MGVIDEDMRSIVDSAKLGFVATVCADGSPNLSPKGTVRVYDDDHLVFLNQASPGTVANLRRDPRLEINVVDFLKRRGYRFKGTAEFHAPGSPVFEWIHDWLLATQGPGYPAIEAVLVTVDRALPVDSPAYQFGHATESELRAAWARTYGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZU5</accession>
    <name>A0A231GZU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42119">
        <property type="protein sequence ID" value="OXR42119"/>
        <property type="gene ID" value="B7C42_05718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="10905" checksum="3C32C1670E56E376" modified="2017-10-25" version="1">MVLALDPPVVASATDTGLILDIIGITIADPLGGGEPQLRLRDGTTVTLPVALRDWAMAMLVTHHHRADDEVPTFPCRIEFGIRDGHMYARPLTAGEDHDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZW5</accession>
    <name>A0A231GZW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42145">
        <property type="protein sequence ID" value="OXR42145"/>
        <property type="gene ID" value="B7C42_05744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="32236" checksum="FB8B9BAC7727E3A1" modified="2017-10-25" version="1">MKAIRFHEYGDPGVLRYEDVDLPVPGPGQVRVRVAATSFNSVDGNIRAGFMRGPMPLTLPHIPGLDLAGTVDALGEGVAEWAVGERVVGFLPFTDDGAAAEYVLAPAEILAAAPANIPLADAAALPVVGLTAWQALFDHAGPKPGQRILISGAGGAVGGYALQLAKAAGAYVIATGSPRSRERVAARGADEVIDHTTTDVAAAVAEPVDVLLNLAPISPAEFAALAGLVRDGGVVVGTTVWMPAPADEARGVRAVDVYVRSDARQLAELVARVDLRELIVDVDERAPLAELASVHTRAAAGTLPGKVVVVPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZX0</accession>
    <name>A0A231GZX0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">hypA</name>
        <name evidence="5" type="ORF">B7C42_05765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42166">
        <property type="protein sequence ID" value="OXR42166"/>
        <property type="gene ID" value="B7C42_05765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020538">
        <property type="entry name" value="Hydgase_Ni_incorp_HypA/HybF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01249">
        <property type="entry name" value="HYPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="13076" checksum="6F8DB342CEB6A779" modified="2017-10-25" version="1">MHELAIAQGIVSGACEHAAGRRVYRVTVAIGMLCAVVPDALYFCFGLAAEGTLAEGAELVVEEIPGRARCRTCGAEFGLPDLIPLCACGSADVDIRAGRELRIRSMEVSDRCAQPADAATTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZX8</accession>
    <name>A0A231GZX8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783736.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42173">
        <property type="protein sequence ID" value="OXR42173"/>
        <property type="gene ID" value="B7C42_05772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="442" mass="48084" checksum="6EADA2EC9DB6E52E" modified="2017-10-25" version="1">MSTARSSRERARAVADAVLYEGYLLYPYRADARKNRCRWQFGVLGPLGAHASGLGEESELTGQMPMAPDGDPVLRFTLRFLQLQHRGVHDADGTPVAETTAAGDTWPDWDEAVEREITVGPCAPVAMTVPFEIPGGRETEPLADPATGPASIVRTRRPVRGEFELAVATEGDHPILSVTVRNTGEPAADRRDALTRSMLGAHVIAEATGAEFVSLLEPPPEAESAVARCVQHRCFPVLAGPRGDRGLMLISPIILYDHPEIAEQSQESLYDATEIDEILTLRVMAMTDEEKAAARATDPRAARIVDSCDAMTAEQMARLHGVLRDPGAGENRLVPEIPPGIDWWDPVADGAVRPDSDAVPIAGTLVRKGSRVRLHPARRADIHDMFFDGREARVTSVHADVDGRTHVGVVIADDPGADLHEWYGRYLYFDPDELEPLDGPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H014</accession>
    <name>A0A231H014_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42206">
        <property type="protein sequence ID" value="OXR42206"/>
        <property type="gene ID" value="B7C42_05805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="20863" checksum="A939F7DA611F4B74" modified="2017-10-25" version="1">MAFIPTGRNDSDPTAHLAVRNALSQAFELVDAMLRSDCAEPQSASGDAVSVTPQRAAGDGIVPFTRGAGLLQRVERAVQRCIGHTQLRSIVAVTGPAQHVPDAVADHVEAVVADTASAAAARAGVAAIVVTVTVADVLTVTIDTLDPTGTTTADALPTAVVSTVHARAREVGGCCRVFPGGRVSWTAPLPPHGKDAIADYPIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H049</accession>
    <name>A0A231H049_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42236">
        <property type="protein sequence ID" value="OXR42236"/>
        <property type="gene ID" value="B7C42_05835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="53" mass="5738" checksum="EC9FC29952F1635C" modified="2017-10-25" version="1">MPSNRDSVFVDDEALASMPAEQPAAVSWPDPSPLDSWWNDVMGLSADPPRPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H072</accession>
    <name>A0A231H072_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrethroid hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pytH_3</name>
        <name evidence="3" type="ORF">B7C42_05847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.88" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779754.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42248">
        <property type="protein sequence ID" value="OXR42248"/>
        <property type="gene ID" value="B7C42_05847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102209">
        <property type="term" value="F:trans-permethrin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011237330" evidence="1">
        <location>
            <begin position="31"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="27805" checksum="2B10964F06A03A9E" modified="2017-10-25" version="1">MRFTRFVKAVSLVFALFAGFVVATVGPANAQTMPTIVLVHGAFADTTSWDAVAADLRGRGYQVVVPENPLRGPAHDAAAVEKTVAGISGPVVLVGHSYGGAVITNIHNPNVRALVYVAAFAPAQGEPVALALDPIRFPGSQLLPPALQMKIVDDSSNALGRNLDAYIADASFHQVFAPDVSDATAATMLAHQKSLAVSANVEPSGQPSWSSTPSWYLVSANDTVIPPAAQRWMAGRIGAHTSEVQASHVALVSQPAVVADVIASAASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0C9</accession>
    <name>A0A231H0C9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42297">
        <property type="protein sequence ID" value="OXR42297"/>
        <property type="gene ID" value="B7C42_05496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="399" mass="44977" checksum="B00595A5D9B5CA42" modified="2017-10-25" version="1">MHVHPLVTEYLRLGLAFDRLEPGFVDAYTGDPALRRAVESAPAPQPRELADRAATLRKELPEAGLSEQRTEFLEAHLRALECSGRKFAGDDISFIDEVRSYFDVDIALGDVEDYRDAHRQLDEVLAGDGPLLDRMTAHRRADEIPPQRLTDCVQAFSGALRELVRERYPLPDHEQVEYEIVGDKPWSGFNYYLGNFRSRVAINSDLKQHMAQLPALIAHEAYPGHHTEHCRKEAGLVAAGQDEQTLFVVNTPQCLMAEGLADLALKSIVGPDWGIWAQEIYADLGLRFDGERAQRLSNASAKLLAVRQDAALLLHDRGRSADEVAEFLQRWSLTTPERARQSLRFLSSPLWRAYISTYVEGYRLLGGWLDRAVDAGDRVARFGRLLDEPLTPAALRKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0J5</accession>
    <name>A0A231H0J5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42363">
        <property type="protein sequence ID" value="OXR42363"/>
        <property type="gene ID" value="B7C42_05562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="58" mass="5878" checksum="1C6DE29E4AC67358" modified="2017-10-25" version="1">MNHARMLVKAIGPQYVSSVCPYRKVGTVIIALLIAALSTGSAAVATATGLASMFAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0U3</accession>
    <name>A0A231H0U3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxymuconate semialdehyde hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylF_3</name>
        <name evidence="2" type="ORF">B7C42_05238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.9" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778073.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42462">
        <property type="protein sequence ID" value="OXR42462"/>
        <property type="gene ID" value="B7C42_05238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018775">
        <property type="term" value="F:2-hydroxymuconate-semialdehyde hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="30029" checksum="821B870D93E53A22" modified="2017-10-25" version="1">MTYLSDQAEDRFVDGPEGERFHYRRFGRPSTVPLVLCMRLRGTVDHWDPALLDALAAEREVIVFDNRGTNASTGSAPTTIDGLADGGIAFLRALGLEQADVLGWSLGGIVAQGIALRAPELVRRLIVAGSTPAGVPNQPPPPARVGEILTHAVNDDEDYLYLFFPDTDHGRSAGLKSLRRLDSRLGRSKAAVGDDTYRKQLAAIAAFGGYYERLTELTLPVLVANGAQDVMINAYASFAMSQRLADAKVVLYSDAGHGFLFQHIEDFAHEVDRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H133</accession>
    <name>A0A231H133_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42556">
        <property type="protein sequence ID" value="OXR42556"/>
        <property type="gene ID" value="B7C42_05333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5754" checksum="9CE20ABD3FB2B9D1" modified="2017-10-25" version="1">MTEQLPRRKPGESGFLRYPTTLASAALLIRVAQGLDEWSEGDRHESRPQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H149</accession>
    <name>A0A231H149_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42527">
        <property type="protein sequence ID" value="OXR42527"/>
        <property type="gene ID" value="B7C42_05303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="17051" checksum="61772025CEF42C6E" modified="2017-10-25" version="1">MTYAVDFTTVSTEGLESSPVAQALAGLRANEARYFKNKYDHVFTVEPAKEAQSTVDWVSRILEDERGIVISSRPVEATAFEADGIRFAYVFYESGLSINVMYSIDDSGKRAVGFKLSDGMEIPTELSSFKFARQKSKLAGTIRGSYFVIKNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1D0</accession>
    <name>A0A231H1D0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778224.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42658">
        <property type="protein sequence ID" value="OXR42658"/>
        <property type="gene ID" value="B7C42_05436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8609" checksum="AB5549595EAA4F35" modified="2017-10-25" version="1">MARKRWSELSERTRRLIVAATVVEGILKLAALVDIARRPAGEIRGSKLRWATAVTLLNSGGAVPIAYFLAGRRQPGTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1F4</accession>
    <name>A0A231H1F4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778218.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42651">
        <property type="protein sequence ID" value="OXR42651"/>
        <property type="gene ID" value="B7C42_05429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="655" mass="70596" checksum="2590A1DF80E8F188" modified="2017-10-25" version="1">MTATATGRPRSALTEWLLQGADEDRYSHHPGPMVKQAEEQHQRSWWQVMCLTGVDYFSTLGYQPGIAALAAGVLSPLATLVLVALTLLGALPVYRRVARESPHGGGSLAMFADILPRWTGKLFILVLLGFAATDFVITMTLSAADGAAHIVENPFVPHALRGHGLAITLALLALLAAIFLKGFAEAIRIAIGLVGVYLALNLVVAVVGVWKVATASHLVVDWGHAMTAQHGSVFAMVGISLLVFPKLALGLSGFETGVAVMPQIKGGPDDTEEHPERRIHGARKLLTTAALIMSAFLLVTSFITVVLIPEREFESGGSANGRALAYLAHQYLGNGFGTVYDISTIAILWFAGASAMAGLLNLVPRYLPRYGMAPEWARATRPLVLVFAVIAFGITWYFDADVDAQGGAYATGVLVLITSAAVAVTLSAARKHQRGKAFGFGAVAAVFVYTTIANIVERPEGVQLASLFIIAIIVVSFVSRARRAFELRAIEVDFDDKAAWLIDKIAASGTIRIVTHDLDDVDARRPDDYREKEAEQRIESHIPAKAPILFLEVIVKDASEFSTDLHVGAVEIDCYKILSVEAAAVPNSIAAILLAIRDRTGMNPHVYFEWTEGNPLLNLLKFLFVGEGEVAPVTREILRRAVADPNQRPHVHVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1T3</accession>
    <name>A0A231H1T3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42801">
        <property type="protein sequence ID" value="OXR42801"/>
        <property type="gene ID" value="B7C42_05139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="38" mass="3561" checksum="51365E9229EBA550" modified="2017-10-25" version="1">MGSLIDILGMGTQSAGSVGTTIVNALITLSGGTPAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1W7</accession>
    <name>A0A231H1W7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sirohydrochlorin ferrochelatase</fullName>
            <ecNumber evidence="3">4.99.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sirB_2</name>
        <name evidence="3" type="ORF">B7C42_05170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42832">
        <property type="protein sequence ID" value="OXR42832"/>
        <property type="gene ID" value="B7C42_05170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="25028" checksum="30D3D0B704109AEE" modified="2017-10-25" version="1">MSVPALVLVAHGTRSATGVRMIAALADAVRAEMGRTGADVPVRTAFVDVLGPTPAEVLRELNGVPAVVVPAFLASGYHVYQDVPREVRDSGHPDVVVTPAMGPDPMLARVMRMRLHEAGMRPGDAVVVAAAGSSDARARHDVRQATAMLAEELGVAVRAAYIATGEPRVPDVVAALRESGAERVFVASYLLAHGLFQQRLREVGADGVAEPLGVHPAVVRLLVDRYRTAAAEFLIPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Y3</accession>
    <name>A0A231H1Y3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate reductase-like protein NarX</fullName>
            <ecNumber evidence="3">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">narX_2</name>
        <name evidence="3" type="ORF">B7C42_05193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42855">
        <property type="protein sequence ID" value="OXR42855"/>
        <property type="gene ID" value="B7C42_05193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="27085" checksum="24D51F4D1F7B7C2C" modified="2017-10-25" version="1">MGLLTLRRRPAPVVEMSDRDRRLVWRIAALVLDYPGADTLAILADLSEAAAALAEPVRTDLLRPLTHLSCTAPLTLARDYVDTFDLRRRASLHLTYYAYGDTRKRGMALLRFKHAYRHAGAELSDRELPDHLPVLLEFAATVDPIGGERLLGEHVPVLEMLRLSLTDSESPYAGALAAVLATLPPPTTADRRRIAELAAQGPPDEDVGLEPYSMNGESMHPAMNPDLYSPPAAGTSATAGLFAGTGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H244</accession>
    <name>A0A231H244_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42897">
        <property type="protein sequence ID" value="OXR42897"/>
        <property type="gene ID" value="B7C42_04783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325502" evidence="3">
        <location>
            <begin position="26"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="460" mass="49268" checksum="3CF63E68C05F0539" modified="2017-10-25" version="1">MRGFLTAVVTVVVASALMGEQPARADDGPPAGPMPQLSPVNLPPSPLQNWIDANIKPPQLTAGPEQSADDQQAALWRAILSSPTGDQTFDSWPANLAGLEPGQIIETRDVTATAAQHMAVPIQRAVLLKFRSTSATGTPSFGTATLITPAASWNGPGPRPVEVHAMPINALGLHCTPGYQLSHDILDRTNTDLVWFLPAIWSALNQGHAVLLPDHEGPLMAYGETNVAGHMMLDSIRAVRNGLPEFGNSRYVVEGYSGGAIAAYATAMLQSEYAPELSDVLMGVASGGLAADYRNIAHRFNGWIASGILLSVSTAIAREHPELLQYMNHLAQWVTTSPTRDLCGDADGPLGVVGIPMDVATNIGNPLDSPVAENLYRQLDLSDRKSGVPLYIYHGAWDPWIPLEDAQRMYGEQCSRGVPAIFRTVPGEHLSSYVTSFPGLEDWINARLRGEPAPSECPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2A6</accession>
    <name>A0A231H2A6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778418.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42972">
        <property type="protein sequence ID" value="OXR42972"/>
        <property type="gene ID" value="B7C42_04858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="7861" checksum="4760D8D00621EE4E" modified="2017-10-25" version="1">MSDRETNTSAAQADPVPERSRELTARADTAGYVLLRSVRPQPEWTLLDRESGEEIFRAAELGAIEQWLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2W2</accession>
    <name>A0A231H2W2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor BepR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bepR_3</name>
        <name evidence="6" type="ORF">B7C42_04617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43195">
        <property type="protein sequence ID" value="OXR43195"/>
        <property type="gene ID" value="B7C42_04617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="24063" checksum="9BEEB2561B4553C8" modified="2017-10-25" version="1">MNDSSAPALDDDSSRTDDGTGDPRLGARAARTRNAILEASKQLFLERGYSGTRINNITDACGISRAGFYTYFRDKREIFNTLGEETYHELLDVVARWDTIAQPCTREDVETWVRGYFAFMDKHGAFILSAQPGPSDEDVKIASTRMQMRVVWLLGMNLRNRQRHPAAAPEALGLCVQAMLDRSWYLSHTQQQLPVDPDDIVRTATDFLMAILTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H396</accession>
    <name>A0A231H396_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43353">
        <property type="protein sequence ID" value="OXR43353"/>
        <property type="gene ID" value="B7C42_04776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="19327" checksum="F15B265039BF253A" modified="2017-10-25" version="1">MYVEQPPEVRNGPTPRPEPADDPAPPVQVQDLHLPEPVAPVAPIQPPDNTIRIGQWQAPAPDWLPPQVRDCINNTAAGAEAQVATALDSIGIPAGRSDRVSGATLAGTGIGGAAGAVAAGAPVATAGAVVGGLIGGTIGGIAGAAVGTVVPVPVVGTVTSGVAGTAVGAAAGAAAGAAVAGIPVAVAGALAGGTVGAGFGAGVGVGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3B4</accession>
    <name>A0A231H3B4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acryloyl-CoA reductase (NADH)</fullName>
            <ecNumber evidence="3">1.3.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acrC_7</name>
        <name evidence="3" type="ORF">B7C42_04739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.95" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009529.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43317">
        <property type="protein sequence ID" value="OXR43317"/>
        <property type="gene ID" value="B7C42_04739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="227"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="356" mass="37098" checksum="7A75D09928538501" modified="2017-10-25" version="1">MDFALSAEQEDLAAGERAWLVKNDPIAARRPSIDDGPARVPDLAARHVVESGLVGLLTAETGGTHVDLAVLVEEHGRAASAVPLAELALATAALDTLDHPLHTLATANAEGKESVPLALTSVDGAPLTVEISGTELRITGTTAPATALLDATGFLVAAPTSDGREVLVHLPANSAGAGVRTLETLDLTRSWSVIELDVTVPGQRWTTVPAGTVPALADALAFYRKMDALGAAERLVEQTVEYAGQRTQFGQPIGSFQAVKHHCADMALRTEAARASLWAAAVALDGADAARRATAVSAAAAYAGEATSTVASLALQVHGGIGFTWEHDLHLLTRRIKVDELLNGSVSWHRRRLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3N0</accession>
    <name>A0A231H3N0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43477">
        <property type="protein sequence ID" value="OXR43477"/>
        <property type="gene ID" value="B7C42_04344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="496" mass="52159" checksum="10ADE20434C4FBB2" modified="2017-10-25" version="1">MDVPTPAPTAPAAPAPAAATAVAPPPPPQLPSAKLNPYNGFHHGLSLLHGWLPLTIEIVAAVLLVIAIARWGRRWWLIRVPICLALGVVAAFVARTVMNNEGLASDPAPVRLWIWVGAAVAAIALVVVGWPGARWWHRTAAIVAVPFAIASSAVVLNQWVGYYPSVQSAWSALTAGPLPHQTDQDELAAMRDSHPAHGVVVPIDTGDAASGFKHRTEYVYLPPAWFSGPTPPALPAVMMIGGEFNTPADWLRSGQIMPAIDAFTAANNGSAPVLVFVDSSGSFNNDTECVDGPRGAAADHLTKDVVPYVDSHFGVPADPAKWAVVGWSMGGTCATDLTVMHPELFHTFVDIAGDLGPTSGTREQTIARLYGGDAAAYDRFDPLTVMAKHGTYTGVAGLFDDLTPPHRQDHTGKDPGGGHFHMPQVDESRIGVGGQDGVMDSGEVGAAEKLCGQGRAVGIECTIHTTQGGHTWQFAAAAFTSSLPWVSARLGLPVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3S1</accession>
    <name>A0A231H3S1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43529">
        <property type="protein sequence ID" value="OXR43529"/>
        <property type="gene ID" value="B7C42_04397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="20778" checksum="10B6BCF3F897E9B2" modified="2017-10-25" version="1">MSENPPSTPRRDDSGAAPVGRDAVVAAVTEAAADLFAERGPAATSIRDIAERAGVNHGLVFRHLGAKDRLVGAVLSYLGEQSGAAAAAGQLTATDPRLRRHLTVLARCILDGYPVGELQEQFPVMTMLIEHLRPQMDSDRAAGLAVAHLAAFTMGWQLLEPFLRSAAGLRELTDAELRASIEAQAGRILRPDPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3U2</accession>
    <name>A0A231H3U2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fine tangled pili major subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftpA</name>
        <name evidence="4" type="ORF">B7C42_04273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782500.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43406">
        <property type="protein sequence ID" value="OXR43406"/>
        <property type="gene ID" value="B7C42_04273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17526" checksum="0D2D4BD7BF1BEF62" modified="2017-10-25" version="1">MAKTSTTTDPIATVLEPEQQRIAGDALCATVVDLIDLSLIGKQAHWNVIGPRFRTVHLALDELVETARGFTDAAAERATAIGVSPDGRARTVAESSSAESFPSGWQQDGDVIAAIVASLAAVVRRLRERIDASEKADPVTQDLLIDIAARLEQLHWMWQAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3U9</accession>
    <name>A0A231H3U9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779144.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43593">
        <property type="protein sequence ID" value="OXR43593"/>
        <property type="gene ID" value="B7C42_04461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="20395" checksum="6C39D8FB3900A939" modified="2017-10-25" version="1">MHPQDPREQHTTRYESGYQPGGYQEPAYQQDPAYQPYRTPAGAPPAPRRPEVNVGMFAGGVLATAVVTALAAWLCAWIIDVVATRATESGKFGVWNPMAEQGYWFAVVAFLCALLAGVLWYLLHLGTPSPDMFFAWIVGILIAAAVVIPLTLSSDIWVGVSTAIEHLVIGLPIFSLTRTVGAKSLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4E8</accession>
    <name>A0A231H4E8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">ggt</name>
        <name evidence="7" type="ORF">B7C42_04454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43586">
        <property type="protein sequence ID" value="OXR43586"/>
        <property type="gene ID" value="B7C42_04454"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059350" description="Glutathione hydrolase proenzyme" evidence="6">
        <location>
            <begin position="33"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="647" mass="67062" checksum="A4EC4D9B3CB9EA2A" modified="2017-10-25" version="1">MRRTRAILAGASAALLLTTGLLTGCSSTTSEAGRSCVEGPDGTPITAAAGPVPNATNLATNPEIATGYRSDMTPVRTHTFAVSTANPLATHAACEVLADGGTAADALIAAQTVLGLVEPQASGIGGGAFLLYYDAAAGSVDAYDGREVAPAAATENYLRWVSDTDQSMPQPNTRASGRSIGVPGVLRLLEAAHRDHGKQSWRDLFGPAISLADNGFDISARMASQIAQSAPDLARDANAKQYFLQPDGSPKPRGFHLANPAMAKTLSAIASDGPDAFYTGAVARDIVDATATTSGGRTPGQISLDDLARYQAKKRTALCTDYRTHRICGMPNPSSGGITVAATLGILENFDLTGLSPDRLDRNGGVPKAEAVHLISEAERLAYADRDKYIADPDFVPLPGGSPAALVNKDYLKQRAALIDPNHSMGTAQPGDFGPVPLGTGVQQPEHGTSHISVVDRYGNAATMTTTVESAFGSFHLVDGFVLNNQLTDFSAQPADAAGVPLANRVQPGKRPRSSMSPTLVFDRTPDGSRGQLVDVAGSPGGSVIIQFVVKALVGLLDWHLDPQQAVSQVAFGAANTPVTGVGGEHPAIDATDNGAHDPLVQKLRELGHQVSVDPQSSGLSALQRESGGWIGGADPRREGIVLGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4I6</accession>
    <name>A0A231H4I6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43626">
        <property type="protein sequence ID" value="OXR43626"/>
        <property type="gene ID" value="B7C42_04494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="387" mass="39231" checksum="A61FD9B80D2A10F7" modified="2017-10-25" version="1">MLVKVRNDDPSRLSNSERTVANWLKTWTGPHALPGIAVVAAGAADAIVWTPKTCVVVVIKDFTERASGTLTVSGYRPWTIGDRIAPLSGTEAGTEPMTEIRARTGEIAELLRGAPGRERVGVTGMVLVMPQLSSRVSLEKGDLPDGIDVVLGDGPAALRNYFTRITADAPDTWNAAQVGQALAALGFAAAASHSDLTAEGFPARLERTPPPPNPVPSRGPEPPAGAPLPGSGPAGVPVAAAAPTSPGGAPVSMARPNPAAQPAPGTVPQPVAASGFGPGGPAGPAPAYGQNQQPYSVPFDPRPPAAPPRSTRNRGLVPLVLLGVLVVVLALAAMCTAGGGSGSRPSHAPASGRTTTTTTSPYTPAPERTVPPSTPGHACYPFQPGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Y1</accession>
    <name>A0A231H4Y1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4352 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783880.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44003">
        <property type="protein sequence ID" value="OXR44003"/>
        <property type="gene ID" value="B7C42_03559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="4">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="21725" checksum="75361729067A99C5" modified="2017-10-25" version="1">MTYQPGPYPQVPPQYVVQQKKSKLPKALLIVVVGIVLLCGVGGCLAGISGKDSAGSQHGTTTAAGNAAGPATKAPPPGINTPVRDGKFEFVVTDVQTGIKEVGDNPYLHRTAQGAYTIVTMTVLNTSKVPYGFSPGNQDLYDTQDRKFSNDTAAAINLEADTSMYANINPGNTITAKVVFDLPADSQPDRIVLHDSMFSGGATVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Y7</accession>
    <name>A0A231H4Y7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781081.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43897">
        <property type="protein sequence ID" value="OXR43897"/>
        <property type="gene ID" value="B7C42_04136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11478" checksum="E01C60A7B738A0F5" modified="2017-10-25" version="1">MIDQAATAAVVRNDAQHRYEVWYGDKLAGFAEYRDNGEDTTFIHTEVDSEFSGKGLAGTLAQHAITDAIERGRAIVPRCSFIKSWLDKHPDYDAHVVGKGIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H532</accession>
    <name>A0A231H532_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_12</name>
        <name evidence="5" type="ORF">B7C42_03609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44053">
        <property type="protein sequence ID" value="OXR44053"/>
        <property type="gene ID" value="B7C42_03609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="21246" checksum="5A26FA784FD82141" modified="2017-10-25" version="1">MPRIQAATVTEHRQAQRRALLDAARAILSEQTGAAPTLAEVAARAGLARPSVYQYFGSRDELFEAVLADALPRWSERIAERMAAAGDPGGKVLAYAMANLELVDEGEHAVVQGLSTHVAADALAAQGRAIHDELRTPLIGALTELGAPDPATTAELINAVVHTASRLVENHTPVDTVAASVRELLDPYLRHTASGTHTPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H599</accession>
    <name>A0A231H599_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Proline iminopeptidase</fullName>
            <shortName evidence="4">PIP</shortName>
            <ecNumber evidence="4 6">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pip_2</name>
        <name evidence="8" type="ORF">B7C42_03581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 6">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4 6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44025">
        <property type="protein sequence ID" value="OXR44025"/>
        <property type="gene ID" value="B7C42_03581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PTHR43722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="36"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="35060" checksum="1854AEDBBB502731" modified="2017-10-25" version="1">MPTTFPPIDPYADGLLEVGQGNRVYWCTSGNPAGRPVLVVHGGPGSGSSPGPRKSFDPNIFRIVQFDQRGCGRSVPSAADPDTDMAVNTTEHLIADMERLRIHLGIDRWLLYGGSWGSTLILAYAERYPARVTGIVLVGITTTRRREIDWLYRGVARLLPVEWERFRAGLPGDGDLVDGYRQLLEHPDPEIRRSAAIEWCRWEDAVIAHESLGRPGQYSAKPDTAMLTFVRICTHYFAHAAWLDEGVLLREAGRLAGIPGELIHGRLDLSAPLETAWELAKVWPDARLHVIDDSGHTGSPAMSDAIARAIARFADPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5U1</accession>
    <name>A0A231H5U1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777553.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44205">
        <property type="protein sequence ID" value="OXR44205"/>
        <property type="gene ID" value="B7C42_03765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="95" mass="10832" checksum="73BE4C31A4429C23" modified="2017-10-25" version="1">MDLHVVAELHARPGREDRLRTALEAMIEPSLAEPGCLDYRPYADPNDPARMVVVERWHGPDALEAHFATPHFRHIAEVLDLILAEPMTLYRLVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5W0</accession>
    <name>A0A231H5W0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pyk</name>
        <name evidence="15" type="ORF">B7C42_03785</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44225">
        <property type="protein sequence ID" value="OXR44225"/>
        <property type="gene ID" value="B7C42_03785"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="354"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR44225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="472" mass="51205" checksum="4BA26259E9FD4C3C" modified="2017-10-25" version="1">MRRTKIVCTLGPATATEDRIRELVDSGMDVARLNFSHGEHADHAENYHKVRHAAEQMGRAVGILADLQGPKIRLGRFIDGRTVWATGEEVRITVDDVEGTHDRVSTTYKQLSEDAKAGDRLLVDDGKVGLTVVRVEGNDVVCRVTEGGPVSNNKGVSLPGMDVSVPALSEKDIEDLEFALRLGVDFIALSFVRSPSDVELVHDIMDRVGRRVPVIGKLEKPEAIDNLEAIVLAFDAIMVARGDLGVELPLEQVPLVQKRSIQMARENAKPVIVATQMLESMIGNSRPTRAEASDVANAVLDGADAVMLSGETSVGQYPIETVRTMARIVHAVESESSTRVPPLTHVPRTKRGVISYAARDIGERLNAKALVAFTQSGDTVRRLARLHTTLPLLAFTPLPEVRSQLALTWGVETFIVPPVGTTDEMIGQVDKELLSLNRYAKGDLVVIVAGSPPGTVGSTNLIHVHRIGEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H625</accession>
    <name>A0A231H625_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777643.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44295">
        <property type="protein sequence ID" value="OXR44295"/>
        <property type="gene ID" value="B7C42_03856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="24455" checksum="A5546F72B67D3A2A" modified="2017-10-25" version="1">MGRIVLVTGGGNGIGKATAARFRADGDTVIITGRQAERLARAAAEIDAEPIVCDATDPQAVAGMADEVGAHLDVVVNMAGGNTDLGRPGGRPASLDQVAAAWRANLDANLLSAVLTTTAVLDKLRPGGSIITIGSIGAEYAASSYGAAKAALAAWTAGLSSTVGARGLTANAVAPGYIAETDFFRGELSEQRRTALVDATHNGRAGRPRDVAETVYFLASAGARHITGQTLHVNGGAHTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H633</accession>
    <name>A0A231H633_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44290">
        <property type="protein sequence ID" value="OXR44290"/>
        <property type="gene ID" value="B7C42_03851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012827752" evidence="1">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="13460" checksum="904D93DEB70D33BA" modified="2017-10-25" version="1">MTIGRICAVAAGLAMAATTTAGLGVAAHADPAGADVEVYTDCGGALPGFPPPLQVVVRNIGTATAENVTVNYWTPFGPSGSVIKATLAPGEIANYTVGTARTLELITARVTSTTPDANPGNNFVLQPMVCMGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H693</accession>
    <name>A0A231H693_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44358">
        <property type="protein sequence ID" value="OXR44358"/>
        <property type="gene ID" value="B7C42_03146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="361" mass="36262" checksum="361326A585ADFA00" modified="2017-10-25" version="1">MNSVAAVPPPALVLVGDRRLRDEVRRIAAAADRGLDERSMPVGRHAWAAAALVIIDLAAARTCADAGYPRRSGVVLVGGGEPDLDHWQAAAAVGAEQVIALPGNTETLIEAFAAYAWRDPGDGLVLAVVGAGGGAGASVFAATLALTAAAQRFRPQILLVDGDPLGGGIDLLLGIESVPGLRWPDLSVEDGRVAAQALHDALPAAAPGLGVLACSRPAGSGPDDIGTGAARAVVEAGRGAGDLVVCDISGNRGPHTDHLLDAADLVVFVVPARLRAVAAAGAVVADVRRRNPNQALVVRGPAPGGLRGREIAEALGLPLLAAMRPQPGLAGTLERGGLTLGRGPLFAGAESVLSALPDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6R1</accession>
    <name>A0A231H6R1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44538">
        <property type="protein sequence ID" value="OXR44538"/>
        <property type="gene ID" value="B7C42_03327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="21751" checksum="214E6FA9DE548BEA" modified="2017-10-25" version="1">MSSAVYLITGIQAAGKSTVAQALAERLPRSAHIRGDVFRRFVVGGRAEMSGEPSEEALRQLRLRHRLAAATADDYAAAGFTAVVQDVVLGESLPWMVEQIRTDPVYVVVLAPRPDAVVRREAGRDKKAYGVFTVEQLDTVLHAETPRIGLWLDTTDLTVEETVGEILARAEPVERRSGPGERLRQWASARRVPRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H724</accession>
    <name>A0A231H724_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513254.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44645">
        <property type="protein sequence ID" value="OXR44645"/>
        <property type="gene ID" value="B7C42_03439"/>
    </dbReference>
    <dbReference type="GeneID" id="66718799"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="6960" checksum="8CA36940857EE5DB" modified="2017-10-25" version="1">MASYLDLLLHPAAGTVLGYINDTLHNIFSNDWGWGSSTPNWGTGSSTGNWGLGSSTPDMWTGSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7C0</accession>
    <name>A0A231H7C0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribosomal N-acetyltransferase YdaF</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydaF_1</name>
        <name evidence="3" type="ORF">B7C42_03441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44647">
        <property type="protein sequence ID" value="OXR44647"/>
        <property type="gene ID" value="B7C42_03441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="20822" checksum="3F30D857363DEC4C" modified="2017-10-25" version="1">MEDCVLTDETVWLSRPAEADIDAIVACCRQPSIPEWTTVPVPYRRADAVGFLTDIVAPGWAAHSPVWAVRTAADGPVVGMVGLDAGPQPGAAEIGFWLGDAVRGRGLMTRSVRLVCDFGFAADGLGLSRIEWRAFVGNVASAAVVRRTGFRYEGLLRGAGVQRGVRRDSWIAGRLAGDPPEPATDWPPLRGPGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7C6</accession>
    <name>A0A231H7C6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777194.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44781">
        <property type="protein sequence ID" value="OXR44781"/>
        <property type="gene ID" value="B7C42_02735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011287142" evidence="2">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="15391" checksum="3E5918D95E14ED96" modified="2017-10-25" version="1">MSQSRWMTRGALAVGAALAVALVAGCGGASTGSAGPEKSGASATSTAARPSGSAGVTAKPGQTSPVQVPDPVAQKLCDAISPQLSDWRVQGPTLGKVALNITVHQWAAENGGINLAVLGDKAVVDRITTKTCSDTRNQALQALELPDLASGIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7P4</accession>
    <name>A0A231H7P4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">panB</name>
        <name evidence="9" type="ORF">B7C42_02731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44777">
        <property type="protein sequence ID" value="OXR44777"/>
        <property type="gene ID" value="B7C42_02731"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="25476" checksum="D877984BD7A66128" modified="2017-10-25" version="1">MLTAYDYSTAKLFEEAGIPVLLVGDSAANVVYGYDTTVPITIEELLPLVRGVVRGAPHALVVADLPFGSYEGSPEQALASATRFMKEGGAHAVKLEGGERVSEHIARLTASGIPVVAHIGFTPQSVNTLGGYRVQGRGDGAEQLIADAIAVQEAGAVAVVMEMVPAELAGQVTNKLTIPTVGIGAGSDCDAQVLVWQDMAGYTSGKTAKFVKRFGRVGDELRSAAAEYAREVAQGTYPGPEHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7P6</accession>
    <name>A0A231H7P6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma-F factor antagonist RsfA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsfA_3</name>
        <name evidence="3" type="ORF">B7C42_02819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44865">
        <property type="protein sequence ID" value="OXR44865"/>
        <property type="gene ID" value="B7C42_02819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="17675" checksum="1D6DC06A20AFAC08" modified="2017-10-25" version="1">MFPSEGESRPGPPFDGVADAECGPHPDLRAVVRERSHAAILCFRGEADTAALAVWRELIRSGAAFARQAGGHLVIDTTRLRFLGWRALAVLAEEADRLPVELALVSSSPTVARMVDAGDIDAHVPLYGTVVEALGPVGPPRPASSTSPTPSRGRHRPSVRTACPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7W9</accession>
    <name>A0A231H7W9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44847">
        <property type="protein sequence ID" value="OXR44847"/>
        <property type="gene ID" value="B7C42_02801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="28276" checksum="9F98751085FAA901" modified="2017-10-25" version="1">MSANASAAELLATVERSPQAVAVHDRAAWVDLFAPDGRVEDPVGSRPHIGRQAIERFYDTFIGPNHIVFHVDHDVVRGATVFRDLVLDTTMSTGVTLRVPMHLRYDLTRVGGEWKIARLYAHWELPVMVGQLLAAGGRGLAAATKLAPQLLGNQGIGGAVGFSRGFIRVGAAGKRAATGLLEAAGRGDVAGVRAVLSPRAVVEWPAGSDVGHAEFVKRVRGLEVGKTIAAGRFVTVSVRTPAERGIAELEVDGRRVVALRGFVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8D0</accession>
    <name>A0A231H8D0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44986">
        <property type="protein sequence ID" value="OXR44986"/>
        <property type="gene ID" value="B7C42_02943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15420" checksum="53E63FC0AEE6905F" modified="2017-10-25" version="1">MPTMTRTEREKFLAELHVGVIAVERPDRAPLAVPIWYGYEPGGEVVVWTDAGTVKEKLIRAAGRFSITAQVEQPPYRYVTAEGSVTSIDAASPEVARAIAVRYLGPEEGAQFAEQNLGPDSVVIRMRPERWLSTDYSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8E0</accession>
    <name>A0A231H8E0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromate reductase</fullName>
            <ecNumber evidence="2">1.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45052">
        <property type="protein sequence ID" value="OXR45052"/>
        <property type="gene ID" value="B7C42_03009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="187" mass="19221" checksum="3E20AD764993889F" modified="2017-10-25" version="1">MSQTRILALVGSLRAGSINRQLAEAAAQTAPEGVEVDIYDGLGNIPFYNEDIDVAGQVPAPAQALRDAVAAADALVLFVPEYNGTIPAVLKNAVDWASRPYGAGSIKGKPVAVISASISQNAAKWAHGDTVKAVGVAGGSVVESAHLHFGTIGQRFGEAHPREDAEALTQLAAAITELVAARESVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8J6</accession>
    <name>A0A231H8J6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45165">
        <property type="protein sequence ID" value="OXR45165"/>
        <property type="gene ID" value="B7C42_03123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="28707" checksum="35F4E0D9EE8BEBB6" modified="2017-10-25" version="1">MSSYLEPPELVSQIPPAAVLTVFGLVAGASAVSAVIISVRRRDLLPIAACIGALLCALNEPIYDLLGLIVYAGNHPMAFTSFGRSVPWFLVVGYLPWVGLLPYLIYRSMKVGISRTKLHLVAFISFLSVVVVESIGTSFDAWTYYGAPPLKFLVVAPQMAPVPIVGGFLLFAVADRYTGWRRTAVGFIVSTLALPMVFASASWPLYVGLNSDLPTVVNWLLGIVMLGLTAGVVMATTKLAQDIRTARSGASTETDRPLTAAAYAQPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H991</accession>
    <name>A0A231H991_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45425">
        <property type="protein sequence ID" value="OXR45425"/>
        <property type="gene ID" value="B7C42_02550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012398511" evidence="1">
        <location>
            <begin position="32"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="399" mass="42792" checksum="CBE6C23882D85718" modified="2017-10-25" version="1">MDRTIRRSLVFTCAALLAVLTGCGVQGTPTAAEIDVRTLDVGPYPVDRHSYDATAGSKGALAEGMRMSQAVVPAVRIDPSLTIGAGGRVVVDSTDATRRLLAAVSKPVLDRNKMVVAYVAAGSDKPGSLDSAAAATSVTDLVLRFPDESAARQAARELEDVDFGVAPDLNRKLALPKYSDAYIHYRPGIATIGTFMAYKQFVISLFIERPRSEEADLLAWVQKTLDAEVPALDHFQATAAGGLDALPVDPDGLLARAVVRDRSNRTPDVDRFAVYAAPAFVHISSDETTRQRLVDDTGMDAIAVADNSSVLRVRDADAGARMIKGLISSSGEQYEPADAPKTVPGAKCLALNSSGDPQKDSRFRCYVPYRRYVEVVNANSREDIDQRVEAAYALLANSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9D4</accession>
    <name>A0A231H9D4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent FMN reductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498252.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45441">
        <property type="protein sequence ID" value="OXR45441"/>
        <property type="gene ID" value="B7C42_02566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20547" checksum="65BC4BF9577FBE49" modified="2017-10-25" version="1">MDDPLRLEVIVASVRPERFAPVVADWFLRTARADAGLDVGVIDLAHTPLPTDLTTTPQVEAFRERIGAADGFIAVTSEYNHGYPASLKTALDSAKREWRAKPIGFVGYGGLSGGLRAIEQLRQVVAEIHMVSLRESVSFHEAKRKFDADGNTADGAAVDAAQRLLRQWAWWARHLRTARRTDPYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9E2</accession>
    <name>A0A231H9E2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513428.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45469">
        <property type="protein sequence ID" value="OXR45469"/>
        <property type="gene ID" value="B7C42_02594"/>
    </dbReference>
    <dbReference type="GeneID" id="66718989"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11979" checksum="659E9BA27E6B3FDA" modified="2017-10-25" version="1">MAGQQISNDAASTSQAQTDMANSVDRIRATIARVTEAVDSAKRGWQGDAFSACNKAAQDWDEEAAKLNQILNEMTEEVGHGNKTYTGLESENENEFRQLISQTGGLTNLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9H0</accession>
    <name>A0A231H9H0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ORF">B7C42_02630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513395.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45505">
        <property type="protein sequence ID" value="OXR45505"/>
        <property type="gene ID" value="B7C42_02630"/>
    </dbReference>
    <dbReference type="GeneID" id="66718953"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="13374" checksum="B46D9440A293D043" modified="2017-10-25" version="1">MIQQESRLRVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVKDAIPGGNVKKGDVVKAVVVRTVKERRRPDGSYIKFDENAAVLIKADNDPRGTRIFGPVGRELRDKRFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9M9</accession>
    <name>A0A231H9M9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methanethiol S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.334</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_01946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methylation of methanethiol (MeSH) to yield dimethylsulphide (DMS).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:50428"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:17437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.334"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nurim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.334" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45654">
        <property type="protein sequence ID" value="OXR45654"/>
        <property type="gene ID" value="B7C42_01946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033580">
        <property type="entry name" value="Nurim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040">
        <property type="entry name" value="PTHR31040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="29715" checksum="6589E1FC706F1441" modified="2017-10-25" version="1">MSTTPPGSPGTRRDRPATAAVLMAAYGLVAYLLFLVVFLYAIGWVEGLVVPRDINEGPAASTAVAIVIDLILLSIFAVQHSAMARPAFKRVWTRVVPEPIERSTYVLAATAALALIMWQWRPLPAGVWHVPATPARIVLYAVSLAGWALVLIATFAIDHFELFGVRQVLRHLRAQPDAEPDFRTPTLYRAVRHPLYLGFVIAFWAAPTMTAGRLLFAAVTTGYILVAIRFEEHDLVGVFGDRYRNYRRQVPMLVPHPHHGSRAHPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Y7</accession>
    <name>A0A231H9Y7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45651">
        <property type="protein sequence ID" value="OXR45651"/>
        <property type="gene ID" value="B7C42_01943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="10428" checksum="4A787D4685CD1047" modified="2017-10-25" version="1">MTADSTMTGHGGAARAEGSTTRVHVRGRAAWVLAVAATVLPGFAAIAQPATAAPATSDAGYHIYAHGFMSNGIVGFNASDTGQPTQIPGRAPTGVPNWPARSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA22</accession>
    <name>A0A231HA22_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddn_4</name>
        <name evidence="3" type="ORF">B7C42_01992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45700">
        <property type="protein sequence ID" value="OXR45700"/>
        <property type="gene ID" value="B7C42_01992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16767" checksum="9BDC054D3FABDAFF" modified="2017-10-25" version="1">MPDTRRIATDLRLKTVTGLHRTLLDVTGGRLGTRFKNMPTLTLTTVGRRSGRPHTVVLTVPIVDGDRYLVVASRGGDAVSPAWYHNLCAEPRVEVSFRHGAARPMTARVLTPAEREARWPLVVRAYPGYADYQKRTARRIPLIELSPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA90</accession>
    <name>A0A231HA90_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor KstR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kstR2_2</name>
        <name evidence="5" type="ORF">B7C42_02166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45874">
        <property type="protein sequence ID" value="OXR45874"/>
        <property type="gene ID" value="B7C42_02166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="242"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="431" mass="45239" checksum="C0B2F21FA40E7E6E" modified="2017-10-25" version="1">MPRTRIPAAPAAARADSARRSEILRAAADLFASAGYAGTNVKDVADACGILPGSLYHHFDSKEAIAVELLERYHAALDAVARSAPPPSAITSADGAFAVVNGYATALAACALEHRAALQLSIYEPHTGAGSALIALAADPPVAPIAAMRALLDAAAAHGYLAATVDRSVLAEQLCQTMLHIGLSVLHRENSADHVATVVCRLLLDGLPAEPASPAALDRSAALRAAHDSIATWAAPDGTGDDDRTARLRAVARVEFARRGYEATTMRDIATAAGMGAGSVYRAVESKQALLDSIMGSFHDEISRAYAAVVATDSSAVAKLDALTWINLNALQRFDLEFAIQRAWFRSTPPDTSDVIEVLRRRARQIASVVEQGRADGEITLEGMAESRLSACVRDLIWMPPPVVARVGIRAAHAHSRATLLCGATRTAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAK0</accession>
    <name>A0A231HAK0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pivalyl-CoA mutase small subunit</fullName>
            <ecNumber evidence="4">5.4.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45878">
        <property type="protein sequence ID" value="OXR45878"/>
        <property type="gene ID" value="B7C42_02170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="14020" checksum="700907B27B52C3ED" modified="2017-10-25" version="1">MPARVLVAKPGLDGHDRGAKIVARTLRDAGFEVVYTGIRRRVEEIVSIAVAEDVAVVGLSILSGAHLGLTTKVVQGLRAADAADIAVVVGGTIPQADVPRLLEAGAAAVFPTGTALDQLVSEIRALTATVAGPPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAN3</accession>
    <name>A0A231HAN3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45895">
        <property type="protein sequence ID" value="OXR45895"/>
        <property type="gene ID" value="B7C42_02187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="189" mass="20183" checksum="D87735621CD50473" modified="2017-10-25" version="1">MTASPRANRGPKAAAANRRALVRAAREVFAESGFDAPLNSIARAAGVGPGVLYRHFPTRESMILAVFDDNVVAIEEVANRPGTTAVDLLDFIVDQIAVSAGFIATIDPTGFDDPRLFEVSRRLVDLIGAKLSDTDLRGSLRPELTAEDVVTALAMLAAVLIKTELPARQATARRAWGLLMRGLSRESGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAT5</accession>
    <name>A0A231HAT5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-succinoylsemialdehyde-pyridine dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ald_3</name>
        <name evidence="5" type="ORF">B7C42_02129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.83" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45837">
        <property type="protein sequence ID" value="OXR45837"/>
        <property type="gene ID" value="B7C42_02129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="29"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="492" mass="52423" checksum="BA3A5A027DB503AD" modified="2017-10-25" version="1">MPQGNATAGDGRAVTRRMLIDGELVAGERSFASLNPATGEVYGYAPEASIADTEAAIAAARRAFDTTDWSTDTEFRAHCLEQFYAALRANVEDLRALTIAEVGATRMMTHANQLETPFEIVNYFAGLTRTYPRTEDLGEVEDRGRTHRRWVEREASGVVAAIAAYNYPHQLALAKLAPALAAGCTVVLKGAPDTPLATLALGEVIAQHTDIPAGVVNVLSGSDIEVGKTLTTHRDVDVVSFTGSTAVGRQIMSAAGDSLKRVFLELGGKSAMVVLDDADFGTAAMFGAFSICSHAGQGCAITTRMLVPRERHDEVAEMVAGFMSKVSYGDPGDPKNYMGPLISERQRDKVHGLVQRAVEAGAKLVYGGEKVDPGYFYTPTLLAGVDPDSEIAQEEVFGPVLALIPFDDDEDAVRIANNSVYGLSGGVFSADEDRALAVARRIRTGTMSINGGNYFHPDVPFGGYKQSGIGREMGVAGIEEFLEQKSFAAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB24</accession>
    <name>A0A231HB24_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ORF">B7C42_01098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781438.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46133">
        <property type="protein sequence ID" value="OXR46133"/>
        <property type="gene ID" value="B7C42_01098"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="181" mass="19372" checksum="47F61226701E54B1" modified="2017-10-25" version="1">MIESTTDRDRLAELVRELAVVYGRVTLSSGKEADYYVDLRRATLHHQAAPLIGTLLRELVSDWEFEAVGGLTMGADPVALAMLHAPGRPLNAFVVRKAAKTHGMQRQIEGPEISGKRVLVVEDTTTTGNSPLTAVRALREAGATVVGVATVVDRETGADQVIAAEGLEYRSILGLKDLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBD6</accession>
    <name>A0A231HBD6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_4</name>
        <name evidence="9" type="ORF">B7C42_01040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46076">
        <property type="protein sequence ID" value="OXR46076"/>
        <property type="gene ID" value="B7C42_01040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="383" mass="41239" checksum="080BAB085B811177" modified="2017-10-25" version="1">MSSVWQTPERRELRTTVRGFAEREVLPYLDEWERAGEIPRELHKKAGALGLLGIQFPEAVGGAGGDGIDAAIVAEEMHYAGCSGGLFASLFTCGIAVPHMAASGNTELIERWVKPTLAGEKIGSLAITEPGGGSDVGHLTTSAVRDGDDYVVNGAKTFITSGVRADYVVTAVRTGGPGASGVSLLLVEKDRPGFTVSRKLEKMGWLASDTAELSYVDVRVPVSNLVGAENSGFAQIAQAFVSERVGLAVQAYGHAQRCLDLTLRWCRDRETFGRPLISRQAVQNTLSEMARRIDVARVYTRHVAERAADGETDLIAEVCFAKNTAVETAEWVAHQAVQLFGGLGYMRESEVERHYRDVRILGIGGGTNEILTSLAAKRLGYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBR1</accession>
    <name>A0A231HBR1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bifunctional transcriptional activator/DNA repair enzyme AlkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alkA_1</name>
        <name evidence="2" type="ORF">B7C42_01349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46383">
        <property type="protein sequence ID" value="OXR46383"/>
        <property type="gene ID" value="B7C42_01349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="36640" checksum="0B4E6160271E3252" modified="2017-10-25" version="1">MIEDPRSGLTPPRHRSPHTNASPANHGGTERGHSRTLTTSRPIALAATLAPLRRGQGDPCHRVTPDGAHWRASRMPSGPVTYRLVQAGTDVVAARAWGPGAAEFLDQLPRMLCVDEELDDFAPEHPRIVEAHRRHPGLHMLRTGLVFEALVPAVLEQRVHTITARGSYRKLVWQYGEPAPGPTPAPMRVPPSAQTWRYIPSWVYHRANVDPQRSRTIVTAARMAEKLEAAATMAPEQAAERLRAVPGIGVWTAAEIAQRALGDADALSVGDFHLAAIVGWSLLGRPLDDEGMVEYLEPLRPHRYRAIRLLEISGQARKPAFGPRTPLVDHSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBU4</accession>
    <name>A0A231HBU4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UbiD-like decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ferulic acid decarboxylase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hudA</name>
        <name evidence="2" type="ORF">B7C42_01255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN (prenyl-FMN) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46289">
        <property type="protein sequence ID" value="OXR46289"/>
        <property type="gene ID" value="B7C42_01255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="UbiD/Fdc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="prenyl-FMN binding" evidence="1">
        <location>
            <begin position="173"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="prenyl-FMN binding" evidence="1">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="504" mass="55152" checksum="77E3A882339A70A2" modified="2017-10-25" version="1">MNQSNTPLKHLESLREFIAELERIGEIQRIDTEVDWDLEIGAIIRRSYDLRAPAPLFTDITGYRDTGFRVLGAPGALSGPRHPLARIALALGLPADASGQQIVDVLASARSKPGIEPVVVERAQAPCKENVMLGDDIDLFAFPTPKLHGNDGGRYIQTYGMNIVRTPDGSWTNWSINRMMIADRNTLACLIPAPQHLGIIRSKWTEIGAPMPIALAIGVEPALPWVGGMPLPEGADESHYLGALFGEGIKVVPAETVDLMVPATAEIVIEGHISLDKTVLEGPFNEFPGYNATEATPKQVFHVSAITYRDGAIQPTVAAGPPVEEDHTIIGTTSAAEILYLLRENGLPVSSAWYNFEAAVHWLTLAVRQDWHESTGLASHELIDRIAGVIFTGKTSVNAPKILVVEDDVDITALDEVVWAFATRSHPDVDRGEFHYPPAVSDQLAVYLSEEEAHSFKAGKVVYNCLLADLYPGGRRPVKGSFENGWPAEIQQRVLSNWHKYGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBV6</accession>
    <name>A0A231HBV6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781597.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46302">
        <property type="protein sequence ID" value="OXR46302"/>
        <property type="gene ID" value="B7C42_01268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="13057" checksum="AB114190D7D9FF58" modified="2017-10-25" version="1">MFVVALLLFLPAAVAVVTGVLGLTGTLPPNRFFGVHTDEALRTEEAYRVANRVAGPTSVGAGLLLAAAGAIALVATVWVGLAAAAVALVVALFTLGAGVNAANEAIAGLAPAEVGGCGSSCGACSLRDACQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBX1</accession>
    <name>A0A231HBX1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nagC_1</name>
        <name evidence="2" type="ORF">B7C42_01162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46197">
        <property type="protein sequence ID" value="OXR46197"/>
        <property type="gene ID" value="B7C42_01162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="41905" checksum="FDD957B64986753D" modified="2017-10-25" version="1">MRPARGWPTAAGAVLRAILALGGASRSVVAAHAGLSPATVTSQTRALIEAGLLRESPPVDRSQRVGRPHSPLELDRRNAVAAIHFAATQTRVAVVDIAGTIVAGALVPHRTLEGADLVADAAAALAALRRDLPDDTRLSGVGVATGGWVDPEAGVVLSHPLLRLEDTLVRDVLVQLTGLPVELDSHARAMVHAEQLFGALDFDASAAVLFVGNVIDAAFAVDGRVHYGPGSSAGSLATLVPSDLGPGGPGPLDTYSDRSLERRAAGSGIMAQPTIPALIAAAETDPRAHALFEDRARGLAVVAAALLDVLNPETLIITDRAFTGLPAVRATYFDAIAARAQVRSARHRIIGTSFPNRSLETAAAAVLLHRLYADPLAVAAEGFGAHRKEEPAARFESPQFESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBX4</accession>
    <name>A0A231HBX4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsmG</name>
        <name evidence="3" type="ORF">B7C42_01410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46444">
        <property type="protein sequence ID" value="OXR46444"/>
        <property type="gene ID" value="B7C42_01410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="25980" checksum="1835B37837CC4168" modified="2017-10-25" version="1">MERGAGATPQHSPGGDSVDLTPPAVAAEVFGDRLPLAEQYCAALATAGVERGLIGPREVPRLWDRHILNCAVLGELIPLGASVVDIGSGAGLPGIPLGIARPDLRITLVEPLLRRTKFLAEFVESAGLEITVVRGRAEQPDVRKEAGGADYVTSRAVAPLGKLAKWSLPLIHEHGHMLALKGSSVAEELERDRVELARAGAGHAQILECGVGIVTPPTVVLSVERVPRAEKRANKEANRRARRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC20</accession>
    <name>A0A231HC20_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative FAD-linked oxidoreductase</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46385">
        <property type="protein sequence ID" value="OXR46385"/>
        <property type="gene ID" value="B7C42_01351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="923" mass="99381" checksum="614084D704E7A8B6" modified="2017-10-25" version="1">MTDSWVRALRDRIDGEVDDDARRRAEYSSDASNYRVLPAAVVYPREDEDVAAAVRFAREEGKPITARGGGTSVAGNAIGPGLVLDFSRYMNAVLSIDAESRCARVQPGVVLSGLQQAAGRHGLRLGPDPSTQNRCTLGGMIGNNACGPRAVSWGRTSDTVRGLRILDGTGAERVLADDLSVMPGLAEFTRRNLATLRTEVGRFDRQASGYGLQYLTPERGASIAKAFVGSEGTCGLVLDATVDLVPLPNATAVTVLGYPDMPAAADDVKAVMAGRPIAVEGLDARLVDVVRAHGRPVPELPVGGAWLFVEFAGDTEESAYDSAAAVTAACAALDTRIVTDAGTAARLWRIRADGAGLAGRTPGGEPAWPGWEDAAVPPERLGDYLRDFERLMVDHRVDGLLYGHIGDGCIHVRLDLPIARAPQRFRDFLFDATDLVVRYGGSASGEHGDGRARSELLSRMYSPDALCVFAEFKGLFDPDAVLNPAVLVRPEPVDTHLRLPGLRPVPTAGGFPFPADGDIGAAVHRCVGVGKCRADTRSTGGFMCPSYLATADEKDSTRGRARVLQEVVRGALDWRDEAVAQSLDLCLSCRACSSDCPAGVDMATYKSETLYRAYKGRPRPIDHYVLGRLPRWLAMGTRMPRTVNALTGIRWLRRTGMRLAGMDPRRPAPRLAPRSFRAQWAHRGRDRHPDGPVAMLWIDSFTDAFAPEIGWAAVELVESAGYRVRIPDRRVCCGLTWISTGQLDGARKRLRAVLDAVEEHVRAGGPVIGLEPSCTAALRSDLPQLLPDDPRSAPTARAVRTLAEFLTEQPNWQPPDRSGETVVVQPHCHQHAVTGFDADRRLLWRTGAKITEISGCCGLAGNFGMQSGHYEISVAVAEGGLLPALRAADAATPLLADGFSCRTQAEQLAGRPGRHLAQYLNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCF2</accession>
    <name>A0A231HCF2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46624">
        <property type="protein sequence ID" value="OXR46624"/>
        <property type="gene ID" value="B7C42_01598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="110" mass="12461" checksum="F9D12286CA395501" modified="2017-10-25" version="1">MSAPTKPPDTETVASLTAELADVDRRITGLREEADRGEMFQDVSPQWHGRYLAAVRELAKARTYRERLAQRLADAKRAEEARAEAQRLAERMQQRRAELEREIAEAGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCG8</accession>
    <name>A0A231HCG8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Rieske 2Fe-2S iron-sulfur protein</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775146.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46545">
        <property type="protein sequence ID" value="OXR46545"/>
        <property type="gene ID" value="B7C42_01515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="467"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="518" mass="58713" checksum="D64BD6DBBDD611B6" modified="2017-10-25" version="1">MQITSVGHAGFHIRTAAGTILCDPWVNPAYFASWIPFPDNTGLDWDELGNCDFLYVSHLHRDHFDAKNLLDHVNKDATVLLPDYPVPDLQRELEKLGFHTFFETQDSVKHTITGRDGHELDIMIIALRAPADGPIGDSGLVVSDRETVCFNMNDARPVDMDVLHEQFGHIDIHLLQYSGAIWYPMVYDIPSKTKANFGKQKRQRGMDRARSYIEQVGATWVVPSAGPPVFLDDELRYLNDDGENRYSADNGNIFPDQMVFLEQMRIHGNSGGVLMIPGSVADVRGKELDLTHPFDPAEIYDDKAGYIERMAQRMAPVLEREKASWATEDGTPLLPRLKELFEPIMAQSDLICDGIGYPVGLVMGDETVVLDFPKRLVRGPIEGEGKYRYGFRIAPQLVRTVLRDNEPDWVNTIFLSTRFQAWRIGGYNEFLYTFFKCLTDERIAYADGWFAEAHDDSASTELAGWEVQRRCPHLKADLSKFGVVEGNTLTCNLHGWQWDLESGRCKTSKGHELRSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCK2</accession>
    <name>A0A231HCK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peptide transport permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_01530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497008.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46559">
        <property type="protein sequence ID" value="OXR46559"/>
        <property type="gene ID" value="B7C42_01530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="325" mass="35545" checksum="60015E39B064F6C1" modified="2017-10-25" version="1">MTGFLLRRALNYVVLLALASFLAFSLASLTFRPLDSLEQRNPRPPQSVIDAKAHELHLDQPIPQRYLTWVGGVVHGDFGTTLTGQPVSQELPRRIGVSLRLLIVGSVVGTVLGVLIGAAGAIRQYRFTDYFTTIISLLVLSTPVFLLATLLKYGALEINSATGQQIFLYTGETSANAVHGVWNQFVDRLQHMIVPTLGLALGAMAGYSRYQRNAMLDVLQSDFIRTARAKGLTRRRALYKHGLRTALIPMATLFAYSLGALITGATFTEKIFGWHGVGEWLVDAINAQDIYIVVTVTVFAGFVVLVSGLLSDIVYAILDPRVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCR6</accession>
    <name>A0A231HCR6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46711">
        <property type="protein sequence ID" value="OXR46711"/>
        <property type="gene ID" value="B7C42_01687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="28367" checksum="C02C805CC244F774" modified="2017-10-25" version="1">MTPSGPHDRAADESGAVAVLERDHAPVRVRFRLARSLIAAAVAVAGVCYSSWIMEFVLPIHLNPIRSFLSELDAEGRPFRWVFDLGDTIAGSLTLISAVAAMFVFSRRRLSTVGWVALGCFGASTIADAQWPLHTCSGPCPPSDSGMFPQLHQIHALTSTLAVTSIFVAMIAFSVAAFRYRRWPILRHSGLWILIIGSAATAWMLIADNLPGNYALGIAQRIQVGSMSLWLIALAVQIWVAQRAISGDGRKRARPPAPRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD36</accession>
    <name>A0A231HD36_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46685">
        <property type="protein sequence ID" value="OXR46685"/>
        <property type="gene ID" value="B7C42_01660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="71" mass="8220" checksum="726381664FEB2751" modified="2017-10-25" version="1">MWRRLFKPDNCESEEVRRAREAAERAERERREVEAQAPVAKAIGAAVRAALERNHFGEQIDAAFARRRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDE1</accession>
    <name>A0A231HDE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative monooxygenase MoxC</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">moxC_1</name>
        <name evidence="4" type="ORF">B7C42_00028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46914">
        <property type="protein sequence ID" value="OXR46914"/>
        <property type="gene ID" value="B7C42_00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="435" mass="47033" checksum="5A03DC16365CD9CC" modified="2017-10-25" version="1">MPERTMHLNVNVVAAGTHPAAWRVPGANPRAFFDPSHYARVAAIAEAGLFDTAFLADNSYLHPEGYPNSGLDPIVTLSAMAAATSRIGLIGSYSTTFHHPYAIARAFTSLDHLSGGRVGWNVVTSRNKPEGDNYGFSELPDCATRYARAAETVEVVTALWDSWAPGALVLDTESGVAVDRDLITPINHVGAHHSVAGPLQLPPSPQGRPLLTQAGGSAGGIELAARFADAVFTSALFIEPAREYYAQLKQAAARYGRSRDSIAIMPGINPVVGSTEAEARRRIAEHDEIAGPPTDPVARFAAWLGVDPAAIDPDRPFPLELLKSTGDTYSSVGFDTSARLYLERNRHRTVRELAGDGRQGHRAVVGSAEQVADDLEIWFRTGAADGFVIQFDTLPGGLELFIDHVVPLLQRKAIFRREYGENTLRERFAVPHTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDG8</accession>
    <name>A0A231HDG8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE12</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_00086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46970">
        <property type="protein sequence ID" value="OXR46970"/>
        <property type="gene ID" value="B7C42_00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="388" mass="42059" checksum="ECA6041C8F3C6C06" modified="2017-10-25" version="1">MDFSSDADLDLIRDGVRAVCAKFDDEYWAGLDSRHEFPWEFYKALADGGWIGIAIPEEYGGSGRGLLEASVILNEVAASGAAMNGCSAIHLSIFGMHPLVLHGSEEIKQRYLPKVAAGELHVAFGVTEPDAGTETLAIKTRAVRDGDSYIVRGRKVWTSKAQDADRVLLLVRTTPVEECARRTDGLSLLMADLRDPAVTITPIAKAGRNAVASCETVYDDLVVDAADLVGEEGKGFYYLLDGLNAERILIASEAIGTGKAALRRAVAYAKERVVYGRPIGSNQGIAFPLAEAHSKLEAAELITHRAGWLLDRRLPCGAEANMAKYLGAEAGFQAADVAMQTHGGFGYAEEYHVARYWREARLMKIAPLPQELLLAYIGHHVLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDR2</accession>
    <name>A0A231HDR2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775573.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46885">
        <property type="protein sequence ID" value="OXR46885"/>
        <property type="gene ID" value="B7C42_01864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17799" checksum="C6C722AD80D8D0DE" modified="2017-10-25" version="1">MSFTNGGNDAGRNRTITSIPLSEVDTTANASVGDLVRDAAEQMSTLVRAEVELAKAEVTGEIKKGLQGSVFFIGALTVLLFSSFFFFFFLAELLDVWLYRWAAFLIVFVLMIVVVAVLALLGYRKVRKLRAPEKTIESLKETRTVLPHGFGSHAESPAGKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEG4</accession>
    <name>A0A231HEG4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lepA</name>
        <name evidence="7" type="ORF">B7C42_00371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47249">
        <property type="protein sequence ID" value="OXR47249"/>
        <property type="gene ID" value="B7C42_00371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="579" mass="64210" checksum="EFBAD3E73F4BDD14" modified="2017-10-25" version="1">MLQLTGVVEERQMRAQYLDRMDIERERGITIKAQNVRLPWNVDGTDYVLHLIDTPGHVDFTYEVSRALEACEGAILLVDAAQGIEAQTLANLYLALDKDLEVIPVLNKIDLPAADPDRYAAELAHIVGCEPEDVLRVSGKTGVGVPELLNKVIETVPPPVGEGDAPARALIFDSVYDTYRGVVTYVRVVDGKLTPRQKIKMMSTGATHELLEIGIVSPEPKPTQGLGVGEVGYLITGVKDVRQSKVGDTVTTARDGATEALTGYREPRPMVYSGLYPVDGSDYPDLRDALDKLQLNDAALTYVPETSVALGFGFRCGFLGLLHMEITRERLQREFNLDLISTAPNVIYRVIMEDGTEQVVTNPSFWPEGKVRQIFEPVTKCTIIAPSEFVGTIMELCQSRRGELLGMDYLSETRVEMRYTLPMAEIIFDFFDSLKSRTRGYASLDYEEAGEQEAALVKVDILLQGEAVDAFSAIVHKDAAQAYGHKMTTKLRELIPRQQFEVPIQAAIGSKVIARENIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKTIGRVDVPQEAFVAALSTDSSSDKPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEJ6</accession>
    <name>A0A231HEJ6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="10">APS reductase</shortName>
            <ecNumber evidence="6 10">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">cysH</name>
        <name evidence="12" type="ORF">B7C42_00394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 10">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 10">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="6 10"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47272">
        <property type="protein sequence ID" value="OXR47272"/>
        <property type="gene ID" value="B7C42_00394"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043866">
        <property type="term" value="F:adenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011798">
        <property type="entry name" value="APS_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02055">
        <property type="entry name" value="APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="11">
        <location>
            <begin position="47"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="10">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="25659" checksum="B57576B2A20EE02E" modified="2017-10-25" version="1">MATTLDKLSEAELRGIAEDGAAQLGPHASATELLQWTEDTFGSGYIVASNMQDAVLVQLAAQIRPGVDILFLDTGYHFAETIGTRDAVETVYGVNIVNVQPEHTVAEQDRLLGKDLFARDAGECCRLRKVVPLKKSLAPYNAWVTGIRRVEAPTRANAPLISFDEGFGLVKINPIAAWSDDEMAAYIDQHGILVNPLVEEGYPSIGCAPCTRKPEPGSDPRSGRWAGLAKTECGLHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFI0</accession>
    <name>A0A231HFI0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47731">
        <property type="protein sequence ID" value="OXR47731"/>
        <property type="gene ID" value="B7C42_00856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="369"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="433" mass="47078" checksum="B00F13C40D0DF4A6" modified="2017-10-25" version="1">MTVDSSNRSSLTFSGRPMSSPLKDVWSLSRHMVGHFVENVAPCGTLPGDAIHGDITTITRTCLELAISLLDGRDIPEKTERLKDAAAAWAREGVPIDTIHHAIHEGFKIGFDLVVTNATTKTRTNSGGSSNGGGSAGNDDGEPTLTLTHTDYTNLLQGAKLLVEILDTMTTAVSHAYVRELRAVVSEHHNAVHTLTSALLGGHPTSTMARECGIEIADNYHILALHIPPHPDQANPHLDPTIIARRKLRRIQAALATTTHTTTLSLLSTDGGTLLIPTTTPTDLDTLITHLSHAARVPITATTTTTPTTDIPTATDQTHQLLDMVTRLQSIPGLYRFDDLALEYQLTRPGPGRDHLGTLLNPLDHHPELLTTLQTHIANNLNRQRTARLLHVHTNTVDYRLKRIAQLTGFDPTQASGLWYLRSALVARTYTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFW7</accession>
    <name>A0A231HFW7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47772">
        <property type="protein sequence ID" value="OXR47772"/>
        <property type="gene ID" value="B7C42_00897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="850"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="915" mass="96883" checksum="D02584A09F67A7E2" modified="2017-10-25" version="1">MAELYGRAADIAAIAALLDRARAGESGWLVLRGEPGIGKTALLDHAADLGAGLRVLRGAGVEIEAELPFAGLQLLLRPAVAHLPALHARQRAALEAALRLGDDPGGDAMLVGLAVLSLLTEHAGDTGLVCLIDDAQWLDRASLDTILFAARRLYAEGVVIILAARDGATFARSADLPERRIAGLDSEAAAALLDRRELPAGVRRQVLAEAQGNPLALLELADAARDERPGAAHPGALALTDRLQLAFHGQVSRMPKSTQDVLLIVAAEESGELSAVLRAAAAVGAGIDDLAPAEEAGLLVRGETAETIAFRHPLLRAAVYQRAPLGQRVAAHRALAAALDGPADADRRAWHAAAAATGPDAEVAAALEDTAARALARSGHEAAAAAYERAARLTADPALRAHREALAAQSALNAGDLERAAGLARRVAGRAGATAQLRARVAHVEGLAHFWQGRFAEADALLRAGAAQVADRDPALAVTMLIQALHTGWYLGEQHVRDCVAQLTAVPLADTDPLHPVVTYMASVLDRRDTAGAPPELTRTLEESARRGPVPDQVRLMLCGVAMASGQDADVYGPAEALSREYRGAGAAGRLPTTLFFAAEVEIFTGRLRDARTTAAEALSLAADLGQRQWVSQLSSVLAHIHAAEGDEDRCRHYAEAGLADSTPGSVSPGAAWAHWSLGLLELGSGRAEAALSRFERLTRDPLRHHLCAMRSIPDLVEAAVRVGAPDRAGPHADRLADWATAVRQPWAEALVLRCRALLSDDDSAETHYTRALTLHDREARPVEYARTAQLYGEWLRRARRKSEARTVLTEALDMFDRIGMRPWVERARSELVATGAAPSVPGGQSGSRSGAAVTGLTPQELQIARLAAQGLSNRDIAAQLFLSHRTVGYHLYKAYPKLGVTSRGELKTIADQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSP2</accession>
    <name>A0A231GSP2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xerD_5</name>
        <name evidence="7" type="ORF">B7C42_08289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000106">
        <property type="protein sequence ID" value="OXR39643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781905.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000106.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39643">
        <property type="protein sequence ID" value="OXR39643"/>
        <property type="gene ID" value="B7C42_08289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="77"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="192"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR39643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="416" mass="47360" checksum="E4480F9B7ABF016A" modified="2017-10-25" version="1">MSNGDGWIQKKVRVSPRTGKTTTRFIARITPPGLPEESKSFIKHGRPNEPGTAAHWLAQRREEIRSNTFVSKNDRAWTLGEWAEEWLAGVTGVDKDTLDAYDTAIRLDIKPAQIGDRLLSELDRKAIVEWMSDLTAARSWDDNLKPLAASTANGRRTVLAMILNAANDEGLMTRNPMRRVKMRDADIDVDPIDPEELPTRDQVWELYEVAKSVSPLMAEQIIVSAGTGLRPGELLGLRQRDIRDGEIHVVQQRKLKNTKVKFGAPKSRMSRRRVPIGDEVAAAIDRHLEKFPEERDEGVLFMWKNGKHWHRNTWAANWRRIRDKAGMSGMRYYILRHYYASVLIDGGASPRLVMERMGHTSSVYTLERYARLWPGAEDGTRELIDSGLRRDKNGTSENPATDEPVELDADDWEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSV5</accession>
    <name>A0A231GSV5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000096">
        <property type="protein sequence ID" value="OXR39662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781936.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000096.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39662">
        <property type="protein sequence ID" value="OXR39662"/>
        <property type="gene ID" value="B7C42_08267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9562" checksum="646DA9603F0F35FF" modified="2017-10-25" version="1">MIRTESRAFTRAAFASFVTVAFGLPVLLLITTAWPVGFVALADILAVFSLVALYCTGFQAGYRNRDELALDHAIEAVRFATSDHPEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT61</accession>
    <name>A0A231GT61_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000061">
        <property type="protein sequence ID" value="OXR39806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39806">
        <property type="protein sequence ID" value="OXR39806"/>
        <property type="gene ID" value="B7C42_08118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="80" mass="8626" checksum="2BF81751036F5AC8" modified="2017-10-25" version="1">MIVSLNQAVPEKVAPPNRVVPEKVALSNQAVPEKVALWNRVVPAKVAAMNPVVPEKVARSNAVWPEKVALSNQVVPEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTQ5</accession>
    <name>A0A231GTQ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetone monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pamO_4</name>
        <name evidence="2" type="ORF">B7C42_07919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.92" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000046">
        <property type="protein sequence ID" value="OXR39999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39999">
        <property type="protein sequence ID" value="OXR39999"/>
        <property type="gene ID" value="B7C42_07919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033776">
        <property type="term" value="F:phenylacetone monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="541" mass="59978" checksum="662F1F4DFD44497E" modified="2017-10-25" version="1">MTNQDSDFDAVVVGAGISGLYAVYKLRGRGMRVHGFESAEGVGGTWYHNRYPGARCDVESIDYSYSFDEELQQEWTWSERFATQEEILRYLEHVADRHDLRSAYEFSTRVTATVYDEQTQRWTISTDTGRTVTARFCILATGVLSATNKPDIPGRDTFAGESYHTGEWPHDPVDFTGKRIGVIGTGSSGIQAIPVLAEQAEHLYVFQRTPNYSIPAGNRPLDPDFVAEVKANYAERRRLSRSSGGGTPNSPHPKGALEVDAAERTRIYDQWWQRGGYLFAKAFPDQTTNQAANDTAREYVEAKIREMVRDPQVADQLIPNDHPIGTKRIVTDDGYFHTYNRDNVTLVNLRNTPIAEITETGVRTTEASYDLDVLIFATGFDAMTGSLARIDIRGRGGRELREEWAAGPRTYLGLAVAGFPNMFILAGPGSPSVLANMVLMAEQHVDWISDCLDYLDEHGFTTIEADEESVGEWVTECNEVAARTLFPTANSWYMGANIPGKPRVFMPYIGGFGKYNEICAEVAAAGYKGFELNGGPAPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTX0</accession>
    <name>A0A231GTX0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40073">
        <property type="protein sequence ID" value="OXR40073"/>
        <property type="gene ID" value="B7C42_07828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="105" mass="11046" checksum="2FA749FC05285943" modified="2017-10-25" version="1">MSAEGMWDLSISTPIGRIAVELELHREDGTLVGTASGAGERVSLRDVVLDGDRLTWNQAVTSPMRLNLAFAVTVAGDTLTGTAKAGRLPASKVTGVRRGGAERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUD2</accession>
    <name>A0A231GUD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40233">
        <property type="protein sequence ID" value="OXR40233"/>
        <property type="gene ID" value="B7C42_07658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="373" mass="39707" checksum="52F64DF5FA28D0EF" modified="2017-10-25" version="1">MNAAAPAKQPSAERSREEAAAAFMAMLRRVHEVSGLTAGQIAVSSGLPRSTAYRFIDPKNKTVPKNRDQVGAFLQACRISRAGVLQMLELWDEVNGVAAAPDNEVALALYTPSTDGVHVVDQRTKPPEPGFYPWEDPARWREAPAGAYPRPDMTLPWYQDNDPRHHHYYNLVESCPACTDRKQHKRTRRTPFAFLRPLVARSLPVMLLLASVSPMSLAVWLGPSFTGPLAGIFAVHIVVLMVFGVSRWGRGAAGARHPTPVQLGAGIIAGVGAGTLATLAVSVLLVGVLTGFTVFATTPLWIGLTDLSGIATSRGIFTLITSVWCGVGLGYGAALTMFPILGAILIGAMGTAMAMMQLSGSGGNSPRNEANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUE8</accession>
    <name>A0A231GUE8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776367.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40198">
        <property type="protein sequence ID" value="OXR40198"/>
        <property type="gene ID" value="B7C42_07712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="24825" checksum="45A6C26671FACA1D" modified="2017-10-25" version="1">MSTTTKTTTTVKSRRDPVEDILTLFLAVIGWAVISVFLVAWWALLFPMVSLPIAAVAGLFWFYGWVPALGMALASAAGLVLWRVKAPELFSRFVSRRVRSRFLSWFRYRRQWSARLDDCNLSTRDDLGQAVKIPRLLGIEIGETTDTVRAAMLPGQCPDDWANRTAHLAHAFGAHECRVSIIGPARVQLVFRHADSLAKPILAPFPHIPGGLGGPPRQDHDNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUL9</accession>
    <name>A0A231GUL9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40306">
        <property type="protein sequence ID" value="OXR40306"/>
        <property type="gene ID" value="B7C42_07644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1124" mass="121597" checksum="F6441F4BB3388884" modified="2017-10-25" version="1">MSIDVEQLKRRMSMGAVVVVGAGMSLQARYPDTFGLNGLLWDALDADPHARADLANRLHVPDRPAKVLIGDDFSKWDHAWMTVAASPIARDRFQRGFVALDAGRAHRPSISHEALSRLIHSGQVELVVSFNWDSALERAHERLYGVALPAGVLWKPHGDVSQPDACWILPHEDGFVDPDLLKRLAEMGAAHPRILVVVGYSESDKAVVDNLIAPLDARWRVCRVSPNAKGIDDIAGTADIVLGALAAPLAQHEDNSAWKVVTFTRQRGIEAALEGQRLSPADVDACPPLPEVERVVAALQRTFAVVINGASGSGKSITAYQVAKRLQQQGYEVLRLRDRAKTRTPREWIADAAATVGPKLLFVDDAQDLGADAVDDLAETADTNTLVLIAGVDNVAGGVVTFTVTGTAAVATLERYVLDHMDELLPKVQVLDDQVGGGFGDESFRVRVRYAAREQSAWQFFYTLSGGWQRTAQTLSEVRGIDRSDLAACALAVAQIAGVDSGVTVEQLVPYSIALGRDRAWIEQNLPVLQMRRLAVEDDGVWRIVHLRTAYAVLKSMLHPPSSTYPPTPEVVVPPIASADGSKTIAPRPAPATRTRPSPPPATAAVIESDRLNAVALLQCAVSSAATPLRGLAWLVGRGLSSESAWVIRRSGVRSPDIDKALAERALATPPSGEVGMAAQLLEELAGPDAPIVTETIWKHIDVVLAWVEELTPSDGWAVGNLINVLHNDNPQALNDLLDGVDPASVAAVIQAGGWPHIYSSMKAVERIAQGGGVDFLISVGEAIDEPALHRMFDDLPDLSAADELFSGLAHLNPPLGLRLFESHAGQLAALFSPEPVDRFHDLFETFAFLLQRLSFRSTAYKIPAAVRHATRTFMSALDTSPLVAALAQPKDDLRWHNFEYFVTAFADAAPGEWKKVVDAVDLDLLQKEFVAQLPRPGNKALFILYMIAQSRQPEVLSLLDRHADGIGTIDAVLVHIHPQLCVQLVEGGLPLDLGLYHQQYASAAELLALVGPYSARVAREVGWANQEAFREGLSRNFQPPFTDLSKWTSAADKWAPGLIDDTLMSLGNGTVARWAEAMRKPISKKQIGPLIVRAMATGDTSAAAEAALLVRQFPSLKRLDSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV43</accession>
    <name>A0A231GV43_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40500">
        <property type="protein sequence ID" value="OXR40500"/>
        <property type="gene ID" value="B7C42_07439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12022" checksum="4F68AC1F6967336A" modified="2017-10-25" version="1">MNWPTTILCGAAGGLVVEMVAFLANLNVYRQARRRARAAKKIAPSWNRYFDPGPDAAAAVTRLLLGALAGAVLHGQVTTVLAAVAAGAAAPALFTQLGTVQSMRELTELTDQSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV72</accession>
    <name>A0A231GV72_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780076.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40478">
        <property type="protein sequence ID" value="OXR40478"/>
        <property type="gene ID" value="B7C42_07416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="12353" checksum="AE61A9A67F56074B" modified="2017-10-25" version="1">MSAAAETAPASLLSAAEFRGRTTVSERAVRRLAARAAREVDGVAAGPEVSARVTADTAVLRVRLPVRYPTPVAVVTEACREHLMRRTHELSGLVVPRVDIEVSELVNTIEPAGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV95</accession>
    <name>A0A231GV95_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M78 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40508">
        <property type="protein sequence ID" value="OXR40508"/>
        <property type="gene ID" value="B7C42_07447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="109"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="317" mass="35262" checksum="105A32ECC5DB02A2" modified="2017-10-25" version="1">MLNSYARVLDVPVALLRQVIPEQPPEGIHFRSQTVPQQRRHKVIADANFVAWILNHLMTEAEVEPDFPLTLPSFDADLMEGGAREAAHLLRRAWRIHGPVRDIAGLLEQAGVFIISMPPQVVGVDAVTVRTLGAVTAVILLNDAVPEDRKRHTLAHELGHLVLDDATISRSIRENEDRADAFAGEFLAPYSELRSTVSNIAPAQLEQLEELRARWGVSLSSLIRRAFLAGDLTESQYRYWFRVLNARNLLRAKLASSYPVSPRAAGELLTALRESGYSANDMAELTSCGLRELQDIFGTAWPFLALRPRLRVVTPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVG7</accession>
    <name>A0A231GVG7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiseptic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">qacA_14</name>
        <name evidence="7" type="ORF">B7C42_07304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40619">
        <property type="protein sequence ID" value="OXR40619"/>
        <property type="gene ID" value="B7C42_07304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="540" mass="56126" checksum="43F9EF8BC8AAE29C" modified="2017-10-25" version="1">MQRKNKMISFGDLSAIRRSAAWTLVVTCAAVALVVAAMAALYTALPAVALDTGADQGALTWMVDGYTLVLACLVLPGGAIGDRYGRRRVLTIGLAVFAAASAIPLIVDNPAWLIASRAVAGAGAAFVMPATLSILTASLPDARRAHAVSVWAGVAGSGGVIGMVGSGLLLIRWSWHSIFLGMTAVALTLLAFAFTVPESQDSDRPRLEIRGMFWVVLSIGTAVFAVMEAPSRGWTDTRVLILGGCGVLSIVAFILTELRAENPLLDVRLFRRRGFASGALSITIQFLVTFGVMFLLVQHFQLILGFGPLKSAVALAPMVVPLVAMSLVSPTIAARVGLRMTTAAGLLTIAIGLVALLRLDTHSSYVDVLWPLLIMSAGLGISAAPSTNAIMMDTPAEKHGVSAAVNDATREIGAAIGIAVAGSILSANYSSRIANAMQYLPEPARGPVRSSLAGALEVAKRAGPSAAPLADYAKTAFWAGVQHSVLALSLISLVGALVLIPLAPGRTRTAACNGPRYAKPLNPHSVRVQDFLDVSGPGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVK8</accession>
    <name>A0A231GVK8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782257.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40653">
        <property type="protein sequence ID" value="OXR40653"/>
        <property type="gene ID" value="B7C42_07210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="21027" checksum="EA59193DBD42300F" modified="2017-10-25" version="1">MRIIRDDDGHDQNDDNPRKRLEDIAAGVPADEVGNMIADEVSDFLAAAVRATDRTPAAPAEPSPAQHKPDLRLVPSVVDDEENTTEKVGTTGSSGRVRLLTSTAASSSLVVTAAALAGWGQPAVVAVPVAGYGIGWLAYLWWNAALRPPLPVAVAAIATALARGSAAFARALVGAVKWLTSRATAARFRHDDTATATAEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVN3</accession>
    <name>A0A231GVN3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme bromoperoxidase BPO-A2</fullName>
            <ecNumber evidence="2">1.11.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bpoA2_2</name>
        <name evidence="2" type="ORF">B7C42_07317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40632">
        <property type="protein sequence ID" value="OXR40632"/>
        <property type="gene ID" value="B7C42_07317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="32372" checksum="684F832C47D6BF2F" modified="2017-10-25" version="1">MKTAMTTVSVPTRDGIMLTADYYHHDSDHPAVILLHGGGQSRHAWRTSASRLHERGYPVIVYDARGHGDSDWSADGRYEIEHLADDLLAVREHFELDRAPAVVGASLGGMTILGTHLLAPPDLWGAVVLVDVTPRMEFAGARRIVSFMSAHPDGFASLDSAADVIAAYNPHRERPVRLEGLRKVLRHRDDGRWVWRWDPAFIATRFDAIHGDPADGADQFESLVDTLRLGAGRITAPTLLVRGGLSDLVSHDTVAEFLDLVPHAETVDIAGTGHMVAGDDNDAFTAAVVDFLRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVU9</accession>
    <name>A0A231GVU9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40611">
        <property type="protein sequence ID" value="OXR40611"/>
        <property type="gene ID" value="B7C42_07296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="37412" checksum="96766D019B978BB5" modified="2017-10-25" version="1">MQKLIMWFWGFSQKFRTKFRAMWRADRELRWGVLGAAFVGLLLLASAIVYVVPIGKSTYWADMSETGQIKVGDDVRIAGVPVGTVKSMELGRRSVRVGFTVDRGIFIGDQTTLDIRMLTLIGGHYIAVTSAGSSPLRSTIPSERIRLPYSLARAFQDAAQPIGEVDGSTLRQNLTMLNNSLTNGPAGIRKAVDAFSSLVDVLDRQNREISETLATADEYIGAINKSKAILGGMINSVNLMETVGLDKQSEIYEAVRLMDELLSRIAALEPVYRARLEPVAKSLADAIPELERLGGEMGQVVTNTKDLLSRLQPVAASRDGVVVDQSATVIDAPAVCIPVPGKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWU3</accession>
    <name>A0A231GWU3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41045">
        <property type="protein sequence ID" value="OXR41045"/>
        <property type="gene ID" value="B7C42_06815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="21414" checksum="51B755ED11EA27E4" modified="2017-10-25" version="1">MPASDQGKLRVYVPATIAMLRELVAQREIRAVNDTAFAVTPALREAYASGDDEELAEVAMGEAARASLRLLAEERESALLHADDGDAEPAGTDPDAAEDGESSYSAPVYRRAVIAADVTGTTLRPDLDDAVVRLSGPITYQRIASVHVDLAEAEPQVAKAVDVVDAADLGDPDAEFVLGDAEDHQLAWYAAQELPFLLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX59</accession>
    <name>A0A231GX59_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782284.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41196">
        <property type="protein sequence ID" value="OXR41196"/>
        <property type="gene ID" value="B7C42_06792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011259550" description="PE domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="10825" checksum="ED88B4681698E064" modified="2017-10-25" version="1">MYLQFSSEVIAAVYSTNTAVATTLSGLMHSAAAASTPAPPSADPVSAGLSSAFTSYQGGFFNITNNGITKFHEGNNKLPESIQRYEFSDGEGGAQVSSADAGVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXU6</accession>
    <name>A0A231GXU6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41419">
        <property type="protein sequence ID" value="OXR41419"/>
        <property type="gene ID" value="B7C42_06562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="107"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="26088" checksum="348B6191B658EB8C" modified="2017-10-25" version="1">MAALTPVLLMLVGGIALVQQGILRGMPVLVLLVPAAALGGAAQLSHDVVDGGGVTRIDQPITDWVVDHRLGWLNPAISTFTDAGGVAAMTTLTIVACAWFGVRRRWARLLTTAAVGIGVAVTGSVLKSAIGRHRPPAVDQLVTETSPSFPSGHTLGSTAVVGVLAAMVVLSSRGRAGRVAAVAAAALFAVVIGLTRIYLGVHWATDVLAGWAIGLVWLALCLCPYLWWRARVSSTARPAAPEPPAAAPPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXW2</accession>
    <name>A0A231GXW2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778063.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41464">
        <property type="protein sequence ID" value="OXR41464"/>
        <property type="gene ID" value="B7C42_06355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="189" mass="21154" checksum="2802FABF3E7E66A1" modified="2017-10-25" version="1">MRTLVAFEHMTLDGYASSGEDLGFEFTFRAYDDELQAYAEHIQADFDTAIYGRETYLGMFGYWSQQPNAESSPGERRHAEWVNAVDKIVCSTTLESAEWNNTRLISSDVAAQIEALKREDGGVIAIYASPKLVHSFIDMGLVDEFRIVVHPVTLGSGTPVFHDKAKLDLDLLESKAFGSGAVYLRYQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXW6</accession>
    <name>A0A231GXW6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41473">
        <property type="protein sequence ID" value="OXR41473"/>
        <property type="gene ID" value="B7C42_06365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011266113" evidence="1">
        <location>
            <begin position="34"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="13533" checksum="7EBFF35595FE4624" modified="2017-10-25" version="1">MMTGRNSRSSALFVTALAGMGLAAVSTAAPALAANTIDIKGVGPANVGVDYTCDANSGTSAVKVMVGDPNADAPSAMGTQPQVTCNGQTQSTVVELTGPDGSPAQLQQGQTVQVRVALVDPQDTVVSGKANVFKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXY0</accession>
    <name>A0A231GXY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-succinylbenzoate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menE_3</name>
        <name evidence="3" type="ORF">B7C42_06347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.26" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41456">
        <property type="protein sequence ID" value="OXR41456"/>
        <property type="gene ID" value="B7C42_06347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="459"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="549" mass="58631" checksum="8283EBA8CF7EBE6D" modified="2017-10-25" version="1">MVLSSSAGELARSVGDAFAAASVLRRRGMFDPWHPLDIVRTARDAGIYGPFVTVLAHAARRTPTAPALVDERGTLTFDELDRESNALTRGLAAHGFGPGSVLAVLCRDHRGMVLSLLAAGKLGARVVLLNTGSAGPQLAEVVAREKVAALLLDSEFADRARAVPADIPRLLTWDDEGTSGITTIYAQAEPHSTDPVAAPPRPGGLVILTSGTTGTPKGAPRDKVSPLQSAQFLDRIPLPREKTMVMAAPIFHGTGLSQCTLGWALGNRIVFRQRTFDPARTLAAVAEYRAATLVLVPTMLQRIVDLDESVLRQYDTSSLEVIFAAGSSVSPDLSRRTAEVFGEVLYNLYASTEVAVAAVATPQDMREAPGTVGRPPVGCRVAIYDSDRNPVTTPGVVGTIFVSSGLSFTGYTDGQHKEIVDGLLCSGDVGHFDAAGRLFVDGRDDDMIVSGGENVYPLEVENLLVNRPDVAEAAVVGVDDRDFGKRLRAFVVRTAGASVDAEEIRDYVKANLARHKVPRDVVFVDELPRNATGKLLRRQLETERVAPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY27</accession>
    <name>A0A231GY27_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug resistance protein MdtK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtK</name>
        <name evidence="2" type="ORF">B7C42_06364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41472">
        <property type="protein sequence ID" value="OXR41472"/>
        <property type="gene ID" value="B7C42_06364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="40923" checksum="90E08B29D32FA631" modified="2017-10-25" version="1">MGRQARIARLRQVSGLAAPVVLTSATTLVLGVTHTALLGHHSIEALGVAALVLPVWIWCTALVVPWGSATQILVAHRHGGGDIDAVRTVASTGLSGAAVVGVVVAVAAAVAAPVIVALTAPVGLDRRDATVMVWILLCGLPFTAVTAHLRGVLAGIGDTRSGARVAVAVAVLNVMVSWILIFGAGWGPAGSAIGSTAAVAAGTVALIPRVRRAIGLTTGWNDTVWHAVTRLAVPDVVFGVVAYGSDAVITAVVARAGTVSLAAHRMMSLAVSLVWMLVFGIGVAVALLAGKCLGSGDDRGRQAVVRAGAVLMIGASGAVALLLTALSPVVFRLVTGDAAVSATGRGVVWSLPVLAPVMSIGMVYAAQLRAAGNTKAVMSASVFSVVCVTLPVVWLAAAVLHWGLTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY68</accession>
    <name>A0A231GY68_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41573">
        <property type="protein sequence ID" value="OXR41573"/>
        <property type="gene ID" value="B7C42_06214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="855" mass="94961" checksum="ACF17C9D2185B118" modified="2017-10-25" version="1">MAGGPAGEELWGHKQFGFAEHGELDSPADLGGVGGGGAGQRDRGVERALQGVVTDVADEYRPTGGQQIQGGVGDLGQVIPVGEVLDDRVENDRVEIAPRQCLGDVSRLGQQLDSVTPRELPLLERVREIVDRHRRHVGGDIVLTVRGELRQHQPGADTDLQHSARLQGEDPIHGGRTPLHHLLERNRIIGIAAVPAPEIHAEPRRRHLGVVQLVVHVPPLFDDLGVGGGGVVEDDVGDEVGAVRAPVHGRGGPADVRAGQQRVLDLAQFDPLSAQLDLSVGAAQIIQGSGGGPAHQVAGAIHPRPGLSIGIGHEPFRGQLHPAHIAARQHGPAQIQLAHHSDRGRVQPRVEDQRAYPRHRDADADRLPGRQRREGGTDGGLAGAVAVEHPPSRRPDGHQLPRAGLTGGDHRAHPVEPGRIQRRQHGRGQHRRADPLVLQERGQRLPGIHLRRCHHQRRGRPDRPQHVEDRRIEGRCGHHRNPRIRVQSEHRPLRRGQAQQPGVTDRHPLGDTGRSRGEHHIRGVVHSQPGPPIGVGDRLRGPLGHIPSVDAHDRTRRGTGHRVRPASDHAYRPHRVQHRGDPLDRVGLVQWHIHSAGFGHRPPRHDQLHAAIHRHAHRALRTHARLDQYPRQPRRPLVELAIRHLPGAVDDRRRVRAGRHRRGQQLRRQPDRRCHSRTGPLRQHQIAFTGSQQRDRSHRHRRIRHQKAVEQHFQPGYVPGDVVGVVSIRIPRELNSRRAVTQPRINVDCAILYGIGGQYVVGHFGRPELKRGGEVENVDRRAEFDVHIGPGRLGDQVRPAPELLMPQRTDHGLGHPIAQYTDGVVVMDIDEQRHHVRHHARTSFQRRGRPCRNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYM7</accession>
    <name>A0A231GYM7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator FurA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">furA_2</name>
        <name evidence="4" type="ORF">B7C42_06340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783136.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41699">
        <property type="protein sequence ID" value="OXR41699"/>
        <property type="gene ID" value="B7C42_06340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011253192" evidence="3">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="14664" checksum="31E28207C7BE406C" modified="2017-10-25" version="1">MLRRAALRVTAPRIAVLTAVADHPHSDTDTILGLVRGTLGTVSHQAVYDVLRALTEAGLLRRIQPMGSVARYETRVGDNHHHLVCRSCGVIADVDCAVGDAPCLTAVDDNGFVLDEAEVIYWGLCPSCSLPTSRSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYW1</accession>
    <name>A0A231GYW1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mprB</name>
        <name evidence="11" type="ORF">B7C42_06104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41762">
        <property type="protein sequence ID" value="OXR41762"/>
        <property type="gene ID" value="B7C42_06104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="207"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="267"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR41762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="491" mass="53280" checksum="E4831BEC574722D0" modified="2017-10-25" version="1">MARAHPGHGGRPDRVARLGPRPDPHEMRPPMPLTRSVSLRWRVTLLAASVVAIAVAVTSIAAYALVARALYADVDSQLRSRSEVMVKNNIDLQGFQAIIMFSSLYSNDIGIALIYPDVDVPYAPPQPMDPPIGPAEMAVAHGKADVSLRTANNQRVLARRTKSGATLVISRSLEPTREVLDRLAWLLFTIGGCGVLVAGAAGATVGRTGLRPIARLTAATERVARTDDLAPIPVTGDDELARLTESFNLMLRALAESRDRQRRLVADAGHELRTPLTSLRTNMELLIASSRPDAPPIPEEDMAGLRADVIAQIEELSTLVGDLVDLAREDAPETVYERVDLGEVAERALERVRRRRVDVEFSARLRPWFVYGHDAGLERAILNVLDNAAKWSPPEAQVILTMRETGPGLMEIAIDDAGPGIPPEERELVFERFYRTTASRSMPGSGLGLAIVKQVVSKHGGTITVDTSERGGTLVRIVLPGEPPVAGERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ90</accession>
    <name>A0A231GZ90_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41936">
        <property type="protein sequence ID" value="OXR41936"/>
        <property type="gene ID" value="B7C42_05920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="341"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="422" mass="45834" checksum="E61A7E1C5EC1F85E" modified="2017-10-25" version="1">MTTRSAPHAPIAHTPSTGPLTTGDADRLAELLLSHLRTGIHPFTALPRPLLDGDVKAMIRVCMRWASERGTAAATADPAAFLQVAAARWARADLPIEKVLHAMHVGFGEALEVVARSGEPSCDRLIAWTSAAVELSDLCTGAISRAYVRELKATSGDHHTAVHTLTSALLAGQASSKVARECGIPIAEEYYVLAVHVAAHPDENRPGLDRHVVAGRKLRRIQSALTRQFQDRALAMLSVDGGTILLPADLCGEPELDRAVEVVADYAAAPVTAVMTRCATDAVPAAARRTHELLDTAESIGIGPGLHKFDDLALQYQLTRPGIGRRILETRIAPLDDHPELLRTLHIFFHTDMNRRRTARQLNIHPNTIDYRLRRIGQLTGFDPSRSQGLWYLRSALIARGGTSLMTPSPFPDRAGQSRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H037</accession>
    <name>A0A231H037_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42182">
        <property type="protein sequence ID" value="OXR42182"/>
        <property type="gene ID" value="B7C42_05781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045660">
        <property type="entry name" value="DUF6390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19927">
        <property type="entry name" value="DUF6390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="27443" checksum="8FEB622BCA0B0EE0" modified="2017-10-25" version="1">MSGPQLFARYAYAPNALGYCGPADAPALAGGTDAEIRAVARRFSGAWPYLRVLSSMTGIADPLDPRLVESYWLGGGVGARIDRAEFLSRLLSVIGPIAGGYWRHLGPELAEESAANHNFHVFGIYPWTRLLGRGPADLPLRVLDNCRITWARVCARDATTATVRARRLCWSDSRLSLSAETSRRIELAGAGVDAADIEVGDHLALHWEHICARLDRTRLDRLTSATDWQLAATNRRLDPNSATAARRPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0A2</accession>
    <name>A0A231H0A2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42303">
        <property type="protein sequence ID" value="OXR42303"/>
        <property type="gene ID" value="B7C42_05502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="638" mass="67402" checksum="A3743A39E679D986" modified="2017-10-25" version="1">MAHESFADPATAELMNANFVCVKVDREERPDIDAVYMSATVAMTGQGGWPMTCFLTPAGEPFYCGTYYPKSPRGGMPSFTQLLTAVTDTWTNRRDEVDQAAGQVAQALRDQGAGLPASELTVTPELLAHAVAAVLRDVDERYAGFGGAPKFPPSALLEGLLRHYERTGEDAARQAVSATCAAMARGGIYDQLRGGFARYSVDAAWVVPHFEKMLYDNAQLLRAYAHLARLESSGAPDASASLPQRITEETAAFLLTDLLTAEGGFASAFDADTHVEPGAPGIEGATYVWTPQQLTDALGPEDGPWAAATFGVTAEGTFEHGTSVLTRYTDPGAGPGEDPADARRFDDIRQRLRAVRDRRPQPERDDKVVTAWNGIAITALAEAGAAHDRPEWIDAAARCARYLLDRHLVDGRLVRASLGGATGSAPGVLEDYAWLATGLLALHQATGELSWLDRAQQLIDAAATLFEDPAQPGSWFDTAADAEQLVARPRDPLDGATPAGASAFAETLLTASALSAPDRAARYRTLADATLNAGAIVLARAPRSGGQWLSVAEAALAGPIQIAISQSPDTRATAELLRTARRFAPGGAVVVAGQSDSVPLLTDRPARGGAPAAYVCRGTVCDLPVSEPREVRAALVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0G9</accession>
    <name>A0A231H0G9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42261">
        <property type="protein sequence ID" value="OXR42261"/>
        <property type="gene ID" value="B7C42_05460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="15078" checksum="84DAF56EBB381071" modified="2017-10-25" version="1">MAQIPRLPGLGLADADWLVTAALTVASEHRFPPLAVAVTDVSGAVIALRRANGGMPMTSRLAVAKARTALLTLHPSGQLPLPGEIVDSIQHLFDGDYIPFAGGVLVTENGVILGAAGASGAHATQDEEAVQAAVERWHEYRSHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0J6</accession>
    <name>A0A231H0J6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42373">
        <property type="protein sequence ID" value="OXR42373"/>
        <property type="gene ID" value="B7C42_05572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="45964" checksum="4F6EFA619AB52953" modified="2017-10-25" version="1">MGVGQKYDDSGIPPNDLGRRLREIRAWRGLSLEAAAGLAGISYGYLGKLERGEKSLENRRTLEAIAAALRVAPSEFSPVPWQAEHPSANDAAYAGLVAIENVLDVYELGEDPGLPVREWPAIAADIQRLIELSQSTADYAAQAELMPQLLGELHAVYVRSPAHRHEALIGMIWCYAAAMWTSKRLGGRGLPLLAAKEAQHCAVALESPAWHGFTAWLRGDATGGLSRPEQYRRAVRVADELRPHLNDDDVVQAYGMLHLSAALAAAVQGDRDTSETHLGEADDIARRLDTEVGSFGHMFFGRANVGIWQATIGNEFGDGTKLVERAHRVNVAAVPSASRQAEFHMEIGRALLTDRRRRDEGIATLIRAERLAPQRVHADVFVREAVADQLRSARRDAAGRELRGLAWRIGIAPDSGEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0R2</accession>
    <name>A0A231H0R2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42439">
        <property type="protein sequence ID" value="OXR42439"/>
        <property type="gene ID" value="B7C42_05640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="207"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="349"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="621" mass="67502" checksum="88FBF909D6A1002B" modified="2017-10-25" version="1">MPRRTLDSLVTQVAAELMGVDATTMVAATERVLAKLVDYFDVDFSFVRHTDRERRATVLVAEWPPRQGVPDPDPLRVVYFEQADSVFRAVEHATEPMIARPTPEFSDYQETIRRSGLTDVTTATVPLMSRGEPTGLLGFMKQGDRQWSTREINVLKAIAALLAQLQARVVAEERLRYIALHDDLTGLANRRALLEHMEERLRPGSSGPVAAFFLDLDRLKALNDFLGHTAGDNFIRTLSSRLKEHLDPNDMIARLGGDEFVIVPAKPVDPVAAELEATRIQQLITRRVSVGGETVSRGASVGVALGMPGETTVADLLRRADHALLSAKSGGGNGVAVFTDAMRAQFELQDDVELNLRGAVSDGSLLLHYQPEVDLRTGRIVALEALVRWQHPTRGLLPPGAFVGVAEATNLAGELGRWVLRTALAQFATWRRAGLASNVVIRINVSPVQLVSLDFVECVEDVLRRHGIDGSSVCLEITEHVVVSDLTRTQVTLRGLKRMGVQIAIDDFGTGYSSLSHLKALPVDAVKIDRGFVQRLGASTDDLAIVKSIVGLAGSFGLGVVGEGVETAVAARTLVGLGCYRAQGFLIARPMPADEAEPHLAEGRIPLDLELPRVSRGAHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0R4</accession>
    <name>A0A231H0R4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42361">
        <property type="protein sequence ID" value="OXR42361"/>
        <property type="gene ID" value="B7C42_05560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009677">
        <property type="entry name" value="DUF1266"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06889">
        <property type="entry name" value="DUF1266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="31789" checksum="D4996199028A16D0" modified="2017-10-25" version="1">MVTIIAGPHGLPRISGFPSSDFDPGADKWSGVAIGEDRIRALAIGAYYGRSWSSYNDTVAFQPEHPGSSETRRESTIEGLHESWGVDNAEDARDTIGRLLSGMHAPLFAMVHPLATAAAQDTTRVDRTGLADSHREFLHTVSEVRGYRGVNGIDRDYDAWLQAIKFGIVDRLPQPLNTDATAWDLSRIVFIARAAHTAGYLDEDEAWTLLGRALGKAQQHYRNWRQFAAGFLTGAIFWAATQDLAAAKEQVDERRWMIRGLLMRPSSPWRRVALHPGAPVFGLSPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1F9</accession>
    <name>A0A231H1F9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_05425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42647">
        <property type="protein sequence ID" value="OXR42647"/>
        <property type="gene ID" value="B7C42_05425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="25132" checksum="617602CF908140CE" modified="2017-10-25" version="1">MRGAGPRRRSCGTHHRIIEQSLCYGEVVPRPRIHDLDVVLDHAEALAVAAGVPAVTIRAVAAASGMSNGAIYHSFGSRAELVARMWIRAARRFLDVQNELVDAALADGSGSAAAVEAVVRAAEAPAEFAERYPASSRLVSVLRHDEVLAAELPDSVAAEVRAQQRGLVAVMRRLSAHLWHREDRRAVEVITACIVDLPTALLLSRDRLADPDTRMRLRAAVRAAVTAGPPPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1R0</accession>
    <name>A0A231H1R0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Limonene 1,2-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">limB_2</name>
        <name evidence="2" type="ORF">B7C42_05118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.107" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42780">
        <property type="protein sequence ID" value="OXR42780"/>
        <property type="gene ID" value="B7C42_05118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106319">
        <property type="term" value="F:(R)-limonene 1,2-monooxygenase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106320">
        <property type="term" value="F:(R)-limonene 1,2-monooxygenase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052601">
        <property type="term" value="F:(S)-limonene 1,2-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="30622" checksum="0A50CFD6458F02A5" modified="2017-10-25" version="1">MTAPLRLALSSPIVVRFPGQYSPWEADAGMAELARIAETADRLGFDHLTCSEHTAVPAAVAASRGATYWDPVATLSYLAARTTRIRLATSVLVLPYHHPLEIAKRYGTLDRISGGRVVLGVGVGSLRAEFELLGASWEGRGEQADDAIAALRAAFGVREPSYAGTHYSFSELIVEPAGVQARVPIWVGGRTMRSLRRAVRFGDGWMPFGLPMAELKTMLSQVDSPPGFEVVLPTGPLDPLGEPDRVTRRLATLADAGATLAGCAVTANSAEHYCDQLVALTELVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H285</accession>
    <name>A0A231H285_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42961">
        <property type="protein sequence ID" value="OXR42961"/>
        <property type="gene ID" value="B7C42_04847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013493">
        <property type="entry name" value="CHP02677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09660">
        <property type="entry name" value="DUF2397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02677">
        <property type="entry name" value="TIGR02677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="549" mass="60230" checksum="1071D6A81C02C167" modified="2017-10-25" version="1">MRRRGARAGITLVPVTESADRLLPAEPALFDGVSPTRGETVIEGADRLRLFSFATADKRNDYLWVLRAFDHARAAYVVLLHASDVADTLARMPDAPHPTATEIGPLLEQLHTWGVLERSYDGTRAATLAEYRNRHYVYQFSQAGFQAYRAVSEVLGARLDEASLSRLVLPELLADLQALAQANRDGDAERVYRILKRLDTALSELADRAAHFYLTLGDLVRTTEATPEAFLAHKDALLAHMRDFSMDLARYAPRLAAAIAEVDDTGAESLISRAASCDERVLLDLAAREADWRARWQGLRGWFVAVRDRSTPEPGAESAPATEAERLREATMSAIAAVLSLLRRVTETRKGGVSRESALRHLAGWFAAAPTTDSAHALFDVVFGLGKPRHLSMEHPDADIIPAHRSWWEAAPLEIARTLAETGRQPTPGAPARLVRNDAGVRRLRQAQLETQRARAAAAMSLAAADVHDRVLDARETEVLLRLLDAASTAWVPVSGRVSTTGSDSGVTLTVREHPGSTVVRTAQGLLYLDHRRLEVRENSRARTASGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2H2</accession>
    <name>A0A231H2H2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetracycline repressor protein class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tetR_12</name>
        <name evidence="6" type="ORF">B7C42_04930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43044">
        <property type="protein sequence ID" value="OXR43044"/>
        <property type="gene ID" value="B7C42_04930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="243" mass="26383" checksum="B67A0CFF3269578B" modified="2017-10-25" version="1">MPKPSHPASPAPSGSPGPSQPERLTRAAIVDTAIALADADGIDGLSMRRIAERMGVGAMSLYRHVPNKDALLADMTDEVARRYPYPAPEAGWTWRDRVRAAADIDWQLYRLHPWVLFTFAVPRYNFGPHSLACLGWLTEGLLELTDDRREATAMALEVWSYMAGVALQQVSATILAAREDEHDESSGLTALLEGTPRWPSPPALAPLEGTGLGDLLDPVRQLHSGLAAMCDGFAARHGRRGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2L1</accession>
    <name>A0A231H2L1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase 1</fullName>
            <ecNumber evidence="4">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pgsA1</name>
        <name evidence="4" type="ORF">B7C42_04976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43090">
        <property type="protein sequence ID" value="OXR43090"/>
        <property type="gene ID" value="B7C42_04976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="24508" checksum="6E6E259E88209C84" modified="2017-10-25" version="1">MSNRPAGGSGPDHQASEHSEPAREPADPAAGTETDRILTVPNVLSVLRLIGVPVFLWLLLVLHADGWAFALLVASGVTDYLDGKLARLLDQYSRLGALLDPLVDRLYLIATVLGLLVRGILPWPFVVVLIGRDLILSATLPIYRRRNLDPPEVIYLGKAATFALMSALPWMLAGQMDWAAAGFGRAFGWALLWWGTAVYVWTGLLYLRKAFAVARTIPVAPRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Y9</accession>
    <name>A0A231H2Y9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43221">
        <property type="protein sequence ID" value="OXR43221"/>
        <property type="gene ID" value="B7C42_04643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="7995" checksum="7EDAAE155D4F8A48" modified="2017-10-25" version="1">MAEKDIDAADWVEQDLLTKQEAGERLAEEIVRVRARLGELRAGAGDAAAMTMVARRLAAMEAIRDSLQTASSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H349</accession>
    <name>A0A231H349_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aqpZ_1</name>
        <name evidence="8" type="ORF">B7C42_04696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43274">
        <property type="protein sequence ID" value="OXR43274"/>
        <property type="gene ID" value="B7C42_04696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="24901" checksum="97D0526098223993" modified="2017-10-25" version="1">MVTSTEFRSAETNTADTEIAITSARGLGSKYAVELIGTFFLVFTVGAAIRSGNQLAPLAIGAVLMVMIYAGGHLSGGHYNPAVTLAVLVRRRIEFRDAVRYWVAQLVAGLLAALVVRYVVDPARTATTSTLTLTGHTLGAAFAVELLFTFALCYVMLNVATSKSHPDNSFYGLAIGFTVVAGAFAVGAISGGAFNPAVTLGAAVMGVFAWPTLWVYFVAQLLAAAGAGAVFLALNPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H382</accession>
    <name>A0A231H382_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lptB_1</name>
        <name evidence="11" type="ORF">B7C42_04678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43256">
        <property type="protein sequence ID" value="OXR43256"/>
        <property type="gene ID" value="B7C42_04678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="674"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="706"/>
            <end position="713"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="913" mass="94689" checksum="BD8546A0A7F0251E" modified="2017-10-25" version="1">MTQHVVFLLLGLGNGAVFGALALAVVLTYRSSGVVNFASGAIALYTAYIYAYLREGKFLLLVPGLPTSITFGDGLAMWPALLLSIVIAAVLGAVLYVVIFRPLRSAPAVARAVAALGVSLVPAGLVAVELGTDPINVDPIFPATIWRNGDLRISADRLYFAVAILVLAIVLALIFKYTKFGLATRACAETERGAYISGISPDRVAVYNWMLSSAVAGLSGILIAPIVPLVPVAYTLFIVPALAAAVVARFEYVVVAVIAGLSVGALQSEAQYLASKHAALPSSGLPELVPLVLILVVLLIRSRPLPARGAIILRSLGKAPRPRRILPTTVLMVVVAAVALVVLHDRYRTGLIISLIMAIIALSTVVVTGYAGQVSLAQLTIAGVAGFILGPISTSWHIPFPLAPLCAALVATALGVLVGLPALRIRGLTVAVATLAMAYAVEALWFRNVDLVGSSGVAIGSPSLFGWDLGIGSGHGYPRLSFAFLCLFVLVVVALGVAYLRRSSLGSQMLAVRANERAAAAAGVSVVRVKIVAFAIAAFIAGIGGAMLAYQEQTVTFDAFSALNSLVLFGTVYLAGTTSVAGGLLAGVLAANGLVFIVVDEVFSAHGWYPVVASILLIFTVILNPDGIVGPFHTLVARRRGGAGVEKAGAAVGSVPPRAAAPVVAIDSGAPTALELRDVSVHYGGVVAIDDICLSIPRGAIVGLIGPNGAGKTTLIDAISGFADHTGAVLLGTENIDAMPPHQRIRAGLGRTFQAVELYDDLDVQENVRVGLTAGRRRGGGDDQKLSRVLDLLGLSEVRARLAGELSQGQRQLVSIARALVGSPDVLLLDEPAGGLDTNESQWLGDRLRDVRDSGVTIVMVDHDMGLVLGLCDRIHVLDFGKVIASGGAEDIRTDRVVAQAYLGSAHTSGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3E7</accession>
    <name>A0A231H3E7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline transport system permease protein OpuBB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">opuBB_1</name>
        <name evidence="6" type="ORF">B7C42_04257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43390">
        <property type="protein sequence ID" value="OXR43390"/>
        <property type="gene ID" value="B7C42_04257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="51"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="26230" checksum="318F0BF189D0540E" modified="2017-10-25" version="1">MTRLRRLPMDVWFEPLIILVIGIGYIVWYRSTTFTPTEQASLAWSNLQTTIWSHIKLTVVATVIVVVVAIPLGIALTRPALKRLEPIAVNIANIGQAAPAVGLLVLFTFWLGTGFRTAVVGLVVYAILPILQNTIIGLRQVDQRTIEASRGIGFSAARTLVRVELPLAVPVILNGVRTALVILVGTATLSTFIGATSLGTLITTGVTLFLPKLLVSGAILVGLLALIIDWLGRLVELAATPRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3H1</accession>
    <name>A0A231H3H1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43387">
        <property type="protein sequence ID" value="OXR43387"/>
        <property type="gene ID" value="B7C42_04254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="142"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="26988" checksum="12B27E279BAF6C05" modified="2017-10-25" version="1">MIRWSWMYIDRPAARFDDAFAFWTAVTGTGLSARQGEHGEFATLDPATGDAYQAAQAVGGDGGAHLDIDVVDLDRARRAARDLGATLVADHDAWSLARSPHGLPFCLTTGEGRHIPAPVTGPDGSLSRVDQLCFDIPPSGYDGEVAFWAALTGWPVRRTGRAEFTRLLVPAHLPVRILIQRLDSEQEPGAHIDIACADVEAVAAWHESLGARRAHRGAQWLVMTDPVGGVYCLTERDPLTGKVFRRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H492</accession>
    <name>A0A231H492_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43671">
        <property type="protein sequence ID" value="OXR43671"/>
        <property type="gene ID" value="B7C42_04539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="39856" checksum="8C5704B106C2F209" modified="2017-10-25" version="1">MQDDVRLLTEEELAFIHALQLRPRASWTDLGRVLGVDPVTVARRWQRLSDRGEAWISVSPGPAVFDLLCAAFIDIDCTAGQTDAVVTALAAHPHMLTLERAGGSNRILATIATEDFGQMSRYTLDVLPGVPHITAVRTRIVTHWFAEGGSWRIDVLTPDQRDKLRTPPITAGADRSRSVTPLDWALIGELARDGRAPHSALAAAVGISASTAKRRIRELTRLGLLSFRCDFARPLGGWPVAVTFWATAPTAALPEIGYGLIRLPQTRNCAAVSGTHNLVLQAGLHSVAEIARFENQIATLHPELTVTQRTVTLRHEKLLGHILDRHGRARAVVPPDIWRDPAAASLIRTERSSESRVEPRGSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4N3</accession>
    <name>A0A231H4N3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plsC_5</name>
        <name evidence="2" type="ORF">B7C42_04050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43815">
        <property type="protein sequence ID" value="OXR43815"/>
        <property type="gene ID" value="B7C42_04050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="59"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="227" mass="25520" checksum="0C371B1A9D9DE6F5" modified="2017-10-25" version="1">MSEQPGRRRERSGRRPKGLGKRAWLTTQFVRRILRTLAWSNFVHVTVVGRELVPKSGPVIVASNHISMLDAVFLWGALRRRAIAIAMAELWSWPMVGWLVRRLGHIPVVRRDSVSGQSAIAQAEQILRYGGVLIIYPEGRLVASGDTEPYKPGVAKLALATGVPIVPVGTTGTDRVLPMRRNRGDGPAFDRRQRVRIQFGTPIDPAEFDDPETLLDHLRRRIEDLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4S7</accession>
    <name>A0A231H4S7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator AdhR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adhR</name>
        <name evidence="2" type="ORF">B7C42_04138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43899">
        <property type="protein sequence ID" value="OXR43899"/>
        <property type="gene ID" value="B7C42_04138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="16294" checksum="93A106B29F7B2C15" modified="2017-10-25" version="1">MAMTATTANPLEHTEDYERPKYSIGDAAEKSGLTRDTLRWYERIGLMDYIGRDSSGKRRFSDRDLNWLHLIGCLRTTGMSVADMVHYAELVRAGDETTPKRLEMFRKTREGVLAQIEDLHGTLAVLDRKIGLYEGRVAAMQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5C7</accession>
    <name>A0A231H5C7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44153">
        <property type="protein sequence ID" value="OXR44153"/>
        <property type="gene ID" value="B7C42_03712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="23064" checksum="490630EB84623A58" modified="2017-10-25" version="1">MTGRPVSEKWRAAAGFGVVVVLVIAVVALGWARPPRASIPGTDRLGPDSGERVADYLARAHESLSGADTAPRWALATASVGLTTDAVVDIGAGLRISQVLYHVPIDRVYTPVITVPVPAGTAALRAAQAAAAGAMDHVRADDDRTRRLAAVLAARLHSGCACAVNLVVRGTLAQLRGLASRSEIRSVEALPPDASAGAFAVLPLLPEHVEVVAPGPDDGPIPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5E8</accession>
    <name>A0A231H5E8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44012">
        <property type="protein sequence ID" value="OXR44012"/>
        <property type="gene ID" value="B7C42_03568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="24971" checksum="03F4B56D45A9D771" modified="2017-10-25" version="1">MSTRPRTGTDVAVRIRLREDFAEDPDFDPQETFVLQLADELPDVCTRHGEVAIEQRDKDFDFRPKTVQRSAEQQWVQRTAAYEVRFLLRGFYRIATFRWVEVNPPSTVLEGTWPICTKCKRTRQLCQYTGHAIVLLGLAAILVILAATQTTTSAHLPVPLVLAVFPGWGLFGLIAAYLLYRRSTTFVSFRPIADLGWTQIRAHPRFAEAFESRGTVSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5G7</accession>
    <name>A0A231H5G7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44078">
        <property type="protein sequence ID" value="OXR44078"/>
        <property type="gene ID" value="B7C42_03634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="45205" checksum="53018B7A126DDF43" modified="2017-10-25" version="1">MSTSTGSSPGTDTAAGNGLPGGAALTEPFTAAIAEAEKLIAAADFIHDEKDLAEGYDYLAGSIAACLQLSGTHGTSHPYFVSSTGPHAKMGLDNPDTLYYHANVEPGAEYLLTGVRGSTVDLSFQVLRGDYTATDVPNGDDAFDDRRLQIAEDGSYQLRFGPPKADAGPNYFVLGEGASMLAVREVYGDWNAETKGRIRIERVDTIGTAAPEPGVEQLRKRYRAAARALVQRIHTWFNFPKWFYLDLPVNTLTEPRLTPGGLSTQYSSVGHFDLDDDQALVITVPKSDAPYQGFQLGSRWYISLDYVNHQTSLNSAQAQVDPDGMIRMVVSARNPGIANWIETTGRRRGILQFRWQRVAREMTPADGPQFALVPFDEVAAQLPHYDLNRIDEQGWRARIADRQRGFADRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5K3</accession>
    <name>A0A231H5K3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR43996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43996">
        <property type="protein sequence ID" value="OXR43996"/>
        <property type="gene ID" value="B7C42_03552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="12752" checksum="7DCF5B1EDE43BDB2" modified="2017-10-25" version="1">MPRPAIEISDREPTGMGPTTTGTDTADDHSGQQLPKLPTRRTHNQSMAATLRLWHTRNIDLLERVAAGLRHLSPPAACKSTAPIRGRAHATHVMADHATHNCARFRLAAQYIEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H606</accession>
    <name>A0A231H606_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44291">
        <property type="protein sequence ID" value="OXR44291"/>
        <property type="gene ID" value="B7C42_03852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="32671" checksum="24D9510B0C89F5E7" modified="2017-10-25" version="1">MVNPYQPGYPAPQPPGWGVPPNYFGAQSFPGTRPPRRRSAVDIVAGIALAVAAILTAAQSVWAIVGPGRDYAAFEYGFNSAVIPFWVCSLAALVGGIMLSVTGAGSIRIRIVAALGGGALFVSIARSIVILCVDSYVRVSASGNWLAIPAAIAILAAVGTLIAGSGAPAPPASRSAIPVYPGAASYPGPVGYPGVPPGYPAPAVAPNYSAPAVYPAAESSVPAPHGRPSYPGAAAPGYPGAPTPAYPGVPGYPGAPSGAQGDPHAAGPHPVAGPQVAAGTPPAQAHHSAPTGSQPSHASVPEQPGGLDSSSAPTVHAGPSGTPPSQPHLPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H644</accession>
    <name>A0A231H644_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">pheT</name>
        <name evidence="19" type="ORF">B7C42_03838</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44277">
        <property type="protein sequence ID" value="OXR44277"/>
        <property type="gene ID" value="B7C42_03838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="48"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="411"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="739"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXR44277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="833" mass="88844" checksum="416D28B41703A404" modified="2017-10-25" version="1">MRVAQSWLTETLQRTNPGWSLTPEELDAGFVRVGLEVEELDTLRPVTGDIEHPLVVGRVAEITELTEFKKPIRFCKVDIGKPELQEIVCGARNFAVDDLVVVVLPGGVLPGGFAISSRKTYGHVSNGMICSVAELGIGKDHSGILVLEPGTAEPGADANELLGLDDTVIELNITPDRGYCFSVRGLARELACGFDLDYADPAVRTLPDDEADAYPVTVEPESGCTRFAVRRVTGVDPNAVSPWWLQRRLLLAGVRPISPAVDVTNYVMLELGQPLHAFDAAKVNGPLVIRRAHTGETLRTLDEAERTLDAEDVVITDDSGVISLAGIMGGASTEVGDDTTDILLEAATWNPLAVYRTARRHKLVSEAGKRYERVVDPEINVAALDRAASLLAEIAGGTVESALTDVRLPVPATEPIRMDIDLADRTAGVVYPTGTSARRLAQIGCSVEVSVSETGHGQLVVTPPSWRPDLTQPADLVEEVLRLEGLEQIPSVLPKAPAGRGLTAVQRRRRAVSRALAFSGCVEVPAPIFMTAGVFDTWGLDAHDPRRNTMRVLNPLDVEKAELATTLLPALLEVAARNISRGERDLSIYGIAEVVLPGPDTHAVAQLPVDRRPTDEQIRELIESLPAQPVHVAAVLTGRREPRGPWGPGRVAEAADAFALADAVADAAGVTIERRPAAYLPFHPGRCAELLVDGTVVGHAGELHPAVLERSGLPPRTCALELDLDALPLRESRPAPVVSAFPAVLQDVSVSVEKTVGAAQVESALRTGAGELLEDIALFDVYEGAQAGEGRKSLTYALRFRASDRTLTEDEASAARDSAVAAAADAVGAVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6L1</accession>
    <name>A0A231H6L1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_7</name>
        <name evidence="5" type="ORF">B7C42_03219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44430">
        <property type="protein sequence ID" value="OXR44430"/>
        <property type="gene ID" value="B7C42_03219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="34666" checksum="7BDA2B04EDCAAD84" modified="2017-10-25" version="1">MNRSNADPGGTLPGTATQARSTAAEVVVTDALTKSYGDHTAVDAVSMTVRRGEIYGFLGPNGAGKTTTLRMLVGLIAPTSGTATILGRNPGEPESLRRIGVLIEGPGFYPYLSGRDNLRVPARYHRTTGGRRSDRFAEVDEILARVGLADRADDRFRTYSLGMKQRLGVGAALLGSPDLLILDEPTNGLDPAGMAEMRELVTGLAADGHTVVLSSHLLGEVQEICDRVGVISGGTLLTESTVGELRGAATLLVRAEPLETAYPAVRRVVGEHRALLTAAGIRVDAGRAMAPEVARAVIASGADLLELRTDEKSLEEVFFEMTKQEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H723</accession>
    <name>A0A231H723_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aliphatic amidase expression-regulating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">amiC_2</name>
        <name evidence="2" type="ORF">B7C42_03370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776006.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44580">
        <property type="protein sequence ID" value="OXR44580"/>
        <property type="gene ID" value="B7C42_03370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="355" mass="38541" checksum="4CC7FBEEFFA42FD0" modified="2017-10-25" version="1">MFSFGESPDEVVEVLNIVPLQGPVGIVAPSCEAAISLAAKEINSGTGILGRQVRVTTIDGGRSPAEVADEVSALLATGMVDAITGWHISAVRQAVARVTGGRVPYLFANVYEELPNEPAEVVMIGEAPSGHILPAMRWLSREFGTRRWAIIGNDYIWPVATGRDVRAAYRDAVHFERYVPLGTRDFGSILTDPLLDRVDGIVMLLVGMDAVRFNQQFTAMGRAATQLRVSPVVDEQLLLAAGPGANSDLYVASSLFPDVSSDPDRLARYHHMHGRFAPKLTYFGNTAYEALHTLRAMAHAVGSLEVPRMRAALEDGVVLETPSGARMYRDNHVVRPPSLIARAEGVDLRILDTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H761</accession>
    <name>A0A231H761_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_9</name>
        <name evidence="3" type="ORF">B7C42_03426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44632">
        <property type="protein sequence ID" value="OXR44632"/>
        <property type="gene ID" value="B7C42_03426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="445"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="547" mass="60361" checksum="A1CCC7CF2ACC326C" modified="2017-10-25" version="1">MYDAHAYRQYFEHDFTYLNGFRRNVHRYAHHPAIEDPATGTTVTYADLGDRVDRLATGLADAGVEPGDVVAYQLFNGVEFAELYLATQAAGAVGSPMNFRLAAGETSYILASNRPRVFVYDTDLTPMAREALERSTFRPELLVASGPGEPLPGAVRFDELFAATARPLDTQRTVWDETTRLYTSGTTGMPKGVPLNSLVEIFSAHDVVMHFPLSPEDKTLNMTPWFHRGGLYCAGPNPTFYLGSTLVPMRAFDADTTLDHVQRYGLTFLIGAPTNLAMLAHAQETRRRDLSSLRGIVTMGAPLEREAALRYQKVLNPNIFNGYGSTEGFWNTFLRPTDLPAMAGTAGRACIDDDVAVVRVLDDRLAEPEETVAKDGTEVGEVIVRSPKGANAYVDSPEQEARKFHRGWLYIGDLATWDEQEFVTIVGRKDDMLLSGGENVHPVQVEEALNEHPGVDDCLVVGIPDERWGQVVVAYVVAAEPGVGVAELDRHCRTHPMLSAFKRPRAYRFVDSLPVSATGKKLHYKLTEQARDDAAAGLFTYPDKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H765</accession>
    <name>A0A231H765_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_02718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777204.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44764">
        <property type="protein sequence ID" value="OXR44764"/>
        <property type="gene ID" value="B7C42_02718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016795">
        <property type="entry name" value="UCP021697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021697">
        <property type="entry name" value="UCP021697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="41"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="16498" checksum="65FAD6F24AF1D59B" modified="2017-10-25" version="1">MARITGSWLSGPNAAHPGEPQPDDYPGKLLGLPQEGVGSLAPMSRRIFALFVDYFIAMGIAALIVRGAGSLNTVTYLIWFVIGVVTVMLFGFTPGQYFLGMRTVRIDASAPVGFVRSVARQVLLTFVVPALFTDGDRRGMHDRATGTALIRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7A3</accession>
    <name>A0A231H7A3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44627">
        <property type="protein sequence ID" value="OXR44627"/>
        <property type="gene ID" value="B7C42_03421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="PTHR32251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="32713" checksum="470ED1EAA8D78673" modified="2017-10-25" version="1">MSRVGALVRVALAYVIAVVVGLAWLLWGPDTGQLWLNGLIADLIATVVVFVFSRIYQNSSFYDPYWSVIPPLLAFYWWFRSDEPSNSARWWLLMAVMLVWAVRLTANWVSTFPGMHHEDWRYPMVRERAGRFAFAADLFGIHVFPTLQVFAGMIPVYVVATRAGEPFGVLDVVAFVIGAGAVTLEAVADLQMHRFAATKSPGQVMDRGVWAWSRHPNYFGECGVWLSFGLFGLAAAPGSWWVLAGVVTMVAMFVGVSIPMMEQRSLQRRPAYRDVVQRVSAFVPLPPRPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7F2</accession>
    <name>A0A231H7F2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator Mce2R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mce2R_1</name>
        <name evidence="5" type="ORF">B7C42_02910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44953">
        <property type="protein sequence ID" value="OXR44953"/>
        <property type="gene ID" value="B7C42_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="25604" checksum="56F44A9E002B105C" modified="2017-10-25" version="1">MDLVPVRRQNVSDGVFQQLLTQILEGDIRELPSERELAATLQVNRHAIREALKRLEQIGLVRIVHGGPTEVLNLREHAGLDVLAYIATGPLERVSPTLIRSVFEFRHAIGVDAARLAARRADPGTVEALRAAAGRYREPLSRNDLVFVDRAFWTRVVDASDNLPYRLSFNTLIKALDQMPEALEHVLGPEIDDPDGHDALVRAVADGDEGKAAFEAGRLLALSATVVATMLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7L6</accession>
    <name>A0A231H7L6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44924">
        <property type="protein sequence ID" value="OXR44924"/>
        <property type="gene ID" value="B7C42_02880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="35965" checksum="36373A00F2282876" modified="2017-10-25" version="1">MTAAFERLSTRMTVLQAGMLLAPTMHEQGAARYGRIVAAQLAALAIRGHIDVHIGSDGFDGADSLRAVLLPGPPDAVAAEERQLLRHLFGNGYSVRIAACTDGPGWDRLNATVRHELIANGFGWARPDRYRALRTMVRLRRRMLDYAAQRPAWQDNEPLHRAGYPYAVLFAVDTGPGPHWPGPEYGAQAQLSLPWNLPQACAHAVRDSGEIAYSAPPVGTEDRLAEVEQLLIAMDSHSQGVRYHHVVEAERLHRLIDDYRWRYSFHTLTTSPRPEVLRAALLDLVRETEAVRAYVPPGVPGHEEAVLVSMYAVRLSDLVLDRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7R4</accession>
    <name>A0A231H7R4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pdhD</name>
        <name evidence="16" type="ORF">B7C42_02840</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44885">
        <property type="protein sequence ID" value="OXR44885"/>
        <property type="gene ID" value="B7C42_02840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="4"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="360"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR44885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="484" mass="49811" checksum="EC69CD5D81FB23AA" modified="2017-10-25" version="1">MPEFDLLIIGGGPGGYVAAIRAAQRGLHVAVVEKERPGGVCLNWGCIPTKAMLRSAEVFQTLGAAVDFGVQADNVRFDFAAVRRRKDGIVGTLTGGVAGLLRANGVTVIEGHARFTGPTTVEVFEPGPSPVFPDGPRYAAAPTGTPTRTVTATDVIVATGSVPALLPVPGADLPGVITSDGAFGLTEVPRRLVVIGGSAVGVEWAGLFAAFGAEVTVVEMRDRLVPAEDTEIGAALGRSFTERGITVLTGCTVTGIDRTGDALEVDVNGATPRTIAADVVLVGVGRRPNTADLDLKYAGIDTDARGFIPVDDRLRTTVEHVYAIGDVTGKALLAHVASHQGLAAADVIAGHDTHIDYTVIPAATFTHPEIASVGLTEDAARAGGHEVITAKFPFAALGRAQALGDTHGFCKIVAGARHREVLGVHIIGPSASDLIAEGALAMSLEATLDELADTIHAHPTLGEIGMEAALTGLGLPIHIAPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7R9</accession>
    <name>A0A231H7R9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44899">
        <property type="protein sequence ID" value="OXR44899"/>
        <property type="gene ID" value="B7C42_02855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011250002" evidence="1">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="18942" checksum="8F8354556CFB3E97" modified="2017-10-25" version="1">MKLLNPRGFGLMCATLAVGTGLVVAGCSTAVHGTATVNQADAAAFRTEMASSSAAATSSKKAAAQTKAVADNCTPFRETTGAAVTKYNDFVDAHDANAPDQDAKRDAAAQTLEDAARTVEGRVTAAGDALPADLAQKFTDYVNAARGLAGESRKMTYTSPVGTLNDASKRVNDALNAVRTACPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H818</accession>
    <name>A0A231H818_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45021">
        <property type="protein sequence ID" value="OXR45021"/>
        <property type="gene ID" value="B7C42_02978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="23467" checksum="FC20C482E39AA9E0" modified="2017-10-25" version="1">MGSALSPSERPTALSERPAAVTDRTVDYVPETVTRSVKLLVAGNFGVGKTTFVSSVSEIRPLRTEETITEASVGIDDMAGLPGKQTTTVAMDFGRITLNPQLALYLFGTPGQRRFLPLWEELANGALGALVLVDTRRIDKADEVLSILEERGVPYSVAINEFDGAHRFPLSEIRDALDLEPGTPLTALDARDRGTCLRSLITLVEFLFHRLEPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H851</accession>
    <name>A0A231H851_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44906">
        <property type="protein sequence ID" value="OXR44906"/>
        <property type="gene ID" value="B7C42_02862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="18906" checksum="ED62F439B6DC747E" modified="2017-10-25" version="1">MRASDQFADVTCGVVYIHASPAALCPHIEWTLSSALKSPASLRWTAQPAAAGQLRATTDWVGPVGTAGRIAKALRDWPVLRFEVTEDPSEGVDGERYSFVPGLGLWTGAMSANGDVMVGEMRLREIVRSARARGRHGDISADIDRALGTAWDDELEPFRTGGEGAEVTWLRRDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H854</accession>
    <name>A0A231H854_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780990.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45114">
        <property type="protein sequence ID" value="OXR45114"/>
        <property type="gene ID" value="B7C42_03071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="127"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="42084" checksum="8486534798F0E61C" modified="2017-10-25" version="1">MNTPLWNWVVRRRVALANLSLIVVLVLGSGYLARYVLRFNPIPHTFTVTVQLATSGGILPGNDVTFRGTRVGKVADVRVSGDGIDAIAEIDDSAKIPVGGAVHVGRLSAAGEQYLDFRPDADTGPYLSDGAVVERARTSVPIPVQNLLTDLSGFIGGLNPGRLTVIVDELDTALGGGPDRLRNMVSGISRAMAGLSDLLPQTQQLLENLQVIAETTSHAQPDLSTLTAAGSALFQQATAADNEIRKFLDQGPDELSTLGDVVAKNQDPLTDLVTNFVAITKAAKLRQPAIEALFPALRQGIQALGVPAHDGAYHTLADFWPRPTCDYDTIPVSPAKIMTDTRVRLYNYCLTADPALQVRGSANAPRPNLPDNGSGPPPGVTGNEMSRPVPSGPIPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H871</accession>
    <name>A0A231H871_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043786.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44926">
        <property type="protein sequence ID" value="OXR44926"/>
        <property type="gene ID" value="B7C42_02882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021784">
        <property type="entry name" value="DUF3349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11829">
        <property type="entry name" value="DUF3349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11437" checksum="F5A2DBDDDE56510D" modified="2017-10-25" version="1">MNSRTNDEGLLAQILDWLRAGYPDGVPPKDYFPLLALLKKQLNQDELDRILGLLLAGRPDVVDREQVEAAIVEVTRCDPSEDDLRQVAARLAAGGWPLTGFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8F4</accession>
    <name>A0A231H8F4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sseB_1</name>
        <name evidence="5" type="ORF">B7C42_02349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45224">
        <property type="protein sequence ID" value="OXR45224"/>
        <property type="gene ID" value="B7C42_02349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="169"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="275" mass="29006" checksum="A8E41587299A1C82" modified="2017-10-25" version="1">MTAVLISPEELRKSLADSGSRVHLLDVRWALGDPDGPQHYLAGHIPGAIFVDLETELAAPPSPAHGRHPLPSLVHLQKCARSWGLRTGEPTVVYDATGGMAAARAWWLLRWAGVRDVRILDGGLPAWERAGGDLAVGAEPDPKPGDVVLTPGNMPVVEADEVADWRGALLDARAGERYRGQVEPIDPRAGHIPGAVSVPTAENLTPEGTFKTPDQLRARFSDLGSGPVAVYCGSGVTAAHQIAALSVVGVSAALYPGSWSQWSSDPERPVATALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8F5</accession>
    <name>A0A231H8F5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780060.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45129">
        <property type="protein sequence ID" value="OXR45129"/>
        <property type="gene ID" value="B7C42_03086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="10137" checksum="5166BF838A48C2F0" modified="2017-10-25" version="1">MTTNPNLSRIRRGATGIFVAATVAVGGLTVELAVQGGTIGHAAKPAGAVPRVSVDVHAADRVSVPTSPAPQPESSRPGEWTPTPPVQNSDSEPHEHTAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8J2</accession>
    <name>A0A231H8J2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776654.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45333">
        <property type="protein sequence ID" value="OXR45333"/>
        <property type="gene ID" value="B7C42_02458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12326" checksum="E2CBC2D00EDB28F9" modified="2017-10-25" version="1">MLLRFLGKGGSGTNDCPTLYATDQASYAIIGWVTDRPETVEIPHLLLGFLEPDTFVGTTLTDTGRGTFLVSGHPITDRETLDQMMIETDETAIEVPKAERTFYGATASRRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8J9</accession>
    <name>A0A231H8J9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45179">
        <property type="protein sequence ID" value="OXR45179"/>
        <property type="gene ID" value="B7C42_03137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="37483" checksum="692D6A23F8830B7D" modified="2017-10-25" version="1">MLITRPDRQADLRAPRTVHTGLPLADSLRLVARLTDRDRWILRMVHEHRVLTTNQLAALAFPTRNLARRRLAALHRERVVDRFRPFTTSGSAPWHWVLAPDGAGVLAAEAGAEVRELGYRPRRRLDIAHSLHLTHTLGVNDWFTTLAITATDHDAKVVAWWSESRCWRLWGDLARPDGYGRYTRHEARLDFFLEYDLATTSLTRVAAKLLGYAELARSTGIITPILLWVPTGPRELAARHALRDTAASLPDPAAVPVATAAADYLDTTATHPSPADRVWLPLDSTHTRRLHLHELADAWPHRTPAPHDESQDSPITLGGQIMLPAPPPLFEHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8K6</accession>
    <name>A0A231H8K6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FBP_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782387.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45189">
        <property type="protein sequence ID" value="OXR45189"/>
        <property type="gene ID" value="B7C42_02314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBP_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="18264" checksum="73B1299CF5AFEB9B" modified="2017-10-25" version="1">MQPLTEREIRSSFVNCSKGDAKRMPVPRDLDTQPWEDLDFFGWNDRSMPGRAYLVAPQDDRLVGVALRYETGGSGRAQLCSICLTTHTGTGVSLLTAHKVGESGRRGNSIGIYMCTDLACSLYARNKKRPALGNRYREDLTDEEKAERVRTNLRAFIERLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8M7</accession>
    <name>A0A231H8M7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hod</name>
        <name evidence="2" type="ORF">B7C42_02498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.48" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45373">
        <property type="protein sequence ID" value="OXR45373"/>
        <property type="gene ID" value="B7C42_02498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050586">
        <property type="term" value="F:3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="29813" checksum="49E39CEBFFB0A8DC" modified="2017-10-25" version="1">MLVPFARAIDAEIHYEDSGGRGPVVLLGHEFFMDRTMFASQAAALSPEFRIVTWDARGHGRTRDEGLPFTYWTAARDALTVLDQLGVERAVVGGTSQGGFSAMRTALLAPERVAALILISTEAHSPTPQELATSRRFLDRWREPNIRHVLAEHMAHWLIGDDAWHRSVWTKRWLARDPHELEAAAGCLLARDSILHRLSEITCPALVIHPTRAGIPRAHALEMARRLAGSRFCEIEDARQAVNMTHPAQVNAAIRDFLRGDVLTRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9R3</accession>
    <name>A0A231H9R3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45437">
        <property type="protein sequence ID" value="OXR45437"/>
        <property type="gene ID" value="B7C42_02562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="79"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="23528" checksum="A599ED35471F33B3" modified="2017-10-25" version="1">MSILDGFTAADQGISPITDELTARPAMNPTVAPRRNTMDTMQTTNLAELYDLDPLDWSAVVAGLNAGFPQAPGTGGPDRHTCWLATIDPDGSPHVTAVGALWVDGAFWFETGPRTRKARNISRDPRCTLSVALDTFDLSVNGTAERVTDPATVAQRAVDWAGEGWPCRVDDSGAALTADFSAPSAGPPPWYVYRIVARAATALSTVEPGGATRWRFDEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9S4</accession>
    <name>A0A231H9S4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_5</name>
        <name evidence="9" type="ORF">B7C42_01996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45704">
        <property type="protein sequence ID" value="OXR45704"/>
        <property type="gene ID" value="B7C42_01996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="392" mass="42840" checksum="8DF6641FFF50AB11" modified="2017-10-25" version="1">MQLRFDDDVEEFRAEFVAFLDTHLPDAATASRRRSHSSADVPDWARDWQRLQFDHGWLLPGNPPEFGGRNATILQQYVHLQELSNRRIYHSFNPQGVGIVAASLLSFGTEEQKTRWARRILRAEITAALGMSEPGAGSDLAGLRTRAVRDGDEFVVDGQKVWTSGAHDADVLLTFVRTDPDAPKHKGISVLLIPTDTPGVTRRPFASVCGPHDLDFNEVFFEGARVPAENLVGPLHGGWGVANGSLGHERTLLWLSYADRLEELAADFTPETVLDRDHYATLIMDSYALRLLGSAALARAARGEQDVAALSVLKVFGSEAVQTASGHALRAQGAGGLIHPARTTPFNPLNLDAFGASWFERYTRSFAGTIAGGTSEIQRNIIAERVLGLPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9U6</accession>
    <name>A0A231H9U6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041977.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45477">
        <property type="protein sequence ID" value="OXR45477"/>
        <property type="gene ID" value="B7C42_02602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="29638" checksum="A2C8E82B286C07E3" modified="2017-10-25" version="1">MTRSWSFTDLEFVVLWRHFGDEGPPRPFVYTTDIPLEDDFQRECTRLRDRMLARPDHTLFDAVRDCTRPDLAVLVTGFDGHDPHRGEGAVRLLAARREDRGYLLTQLPGRTLLHAGGFTMVQCDPLRLADMVADALPPVDAGASGHILLPPDPESVAGAAEAHYVAADSAGGAPQLWDSYDEPADAAGQRFLDIVPERSGTIEIAQGVSRFGPRGRTVRHLDWRDLSGDGRYVIQAGPPRTATGVDRQGLIAAVNAEIITVIRAIKDERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9U8</accession>
    <name>A0A231H9U8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45635">
        <property type="protein sequence ID" value="OXR45635"/>
        <property type="gene ID" value="B7C42_01927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="37538" checksum="1A6E27738D77423F" modified="2017-10-25" version="1">MAELWRLDRARTRSISPENPTGEPGAGARAETGTGAGAARDLGVGWKVSPSIDLAAGSTVTLADVSGPGVIRHFWLTTDRTVLRRLTLNFTWDDESHPSIDVPLGDFFCNGWEELALVSSEMVVVAPAGGLNSFWPMPFRERARVTLHNPTERSVPVYYQLTYDEIEVGEDAGYLHCQRRHSNPLGTPAVHTIVDDVRGRGRYVGTYLAIAPNAPGWWGEGEIKFHLDGDDEFPTICGTGTEDYFGGAWNFDLDGAYRDYSSPYLGLHQVLPHDEIYTPKQRFGMYRWHVRDPIRFHEELRVTLQALGWQDGGRYLPLADADIATTAWWYQERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Z6</accession>
    <name>A0A231H9Z6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45660">
        <property type="protein sequence ID" value="OXR45660"/>
        <property type="gene ID" value="B7C42_01952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23161" checksum="AA02F8DFA889B260" modified="2017-10-25" version="1">MSDVMSRDALWAMAHAERAALADDLAELDDHQWARPSLCGRWTVEEVVAHLTTSASIGRLRWLVSVAGARFDFDEHNTRRLAEHRGGTPAETLARFRRIVTSTTAPSGHTAAWLGEVIVHAQDIRRPLGILREPSVEAATEVAKFYASRDFAVPSRSTIDGLRFEATDGPFTAGTGPLVTGTTIALTMAMAGRTAYLDDLSGPGVLALRGREVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA64</accession>
    <name>A0A231HA64_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-arabitol-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.301</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.301" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45636">
        <property type="protein sequence ID" value="OXR45636"/>
        <property type="gene ID" value="B7C42_01928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="166"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="34379" checksum="01983F30D14BF4E2" modified="2017-10-25" version="1">MRALVIEKPGEYSVQTIPDPTPGPGEVVIEVSAVGICGTDIHIVEGEFPPTPYPIVPGHEFCGQIVEGPRSGEKVAVDPSLFCGACHYCRIGRGNLCERWGAIGDTVNGAMAQYVAVPEANCFTLPDELPASHGALVEPLSCAVHGFDGLPRTLGSHYLIYGAGTMGLMMLQLAVAAGAASISVVDLNTDRLQVARTLGADAVATNADEFDRPHGWEVVIDCTGAIPAIEDGLTRVRRGGTYQQFGVAPGDATASFSPFRIYNDEITIVGSMAVVHSFGRAVDLVRKGAIDADTMVTHTFGLDQFSEALQAFRDGAGRKIQIAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAH4</accession>
    <name>A0A231HAH4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azoB_2</name>
        <name evidence="2" type="ORF">B7C42_02143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45851">
        <property type="protein sequence ID" value="OXR45851"/>
        <property type="gene ID" value="B7C42_02143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="309" mass="32321" checksum="AD8D6E569298B389" modified="2017-10-25" version="1">MSTDSAPVLVTGATGRQGGATARALVAAGVRVRALVRDRNTNRAKDIESLGAELVTGDLHDRESVIRAADGARAVFSVQMPALTDAGFDFDGEVAQGVTLVDGARIAGVDQFVHTSVTGAGQHTDVPGWAPGRWAVEDSLTAKAAVQDAVRAAGFARWTLVKPGTFMENFLPSMRYMFPRGVDGGLVSVLAPQTRLSLVAVDDIGRAAAAALTDPERFDRVELELAGDYLSMTEIAATLSRALGIPLEAPNMTVAQAVAAGMPPMGAALEWLNVAGQPGRPDYATALGIPLTSFEQWARTHLRTESASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBE1</accession>
    <name>A0A231HBE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46181">
        <property type="protein sequence ID" value="OXR46181"/>
        <property type="gene ID" value="B7C42_01146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="17194" checksum="FF89263E3698173E" modified="2017-10-25" version="1">MPPVQVAVCGPRDCTDAEADTAREVGRLLARAGAVVLCGGGTGVMAAVAEGAAAEGGLVIGIRPDADRAGVCDALSAVVFTNMGEARNAILVSSADAVIVVGGSWGTLSELALANRRGGVPVVSIGGWQILDAEGRAVEGSHRAANAAEAVAFAVAGARPGGSPQGAIPVREKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBF7</accession>
    <name>A0A231HBF7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 8-oxo-dGTP diphosphatase 3</fullName>
            <ecNumber evidence="3">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mutT3</name>
        <name evidence="3" type="ORF">B7C42_01050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46086">
        <property type="protein sequence ID" value="OXR46086"/>
        <property type="gene ID" value="B7C42_01050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="23592" checksum="FEEB6B603E0706EF" modified="2017-10-25" version="1">MRGDGDGFLESPDGTRQWGLFGAAGLLLRAPRQGGGALVLLQHRAPWSHQGGTWALPGGARDSHETSVHAAVREAQEEAGIDPEAVRVRGSRVTSTADSGWTYTTVVADVSETLATTANRESAELAWVPEEEVDARPLHPGFAVAWPGLRAAAARLELDGLAEAAAIAAVLPRTIDLADRGFLWLDTHDAAAPTARIAQRENGSGGYAQYEEALVLTLDQVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBT5</accession>
    <name>A0A231HBT5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tripeptidyl aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.14.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tap_2</name>
        <name evidence="5" type="ORF">B7C42_01248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46282">
        <property type="protein sequence ID" value="OXR46282"/>
        <property type="gene ID" value="B7C42_01248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393891" evidence="2">
        <location>
            <begin position="50"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="103"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="439"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="536" mass="56309" checksum="0FD9E722B9C1AAB7" modified="2017-10-25" version="1">MLDATTAVDRPDGETARMGRRGLPVAARSATVAVLTAVLAALAPASAHAEPGFGTCPAGSVGERTPARCASISVPMDYSAPDDARIDVTVSRIRASGQRYGTLFANPGGPGADALDYWGARLSQLPKDLVEHYDLVAVQPRGLRWSTPLTCGAEIAQDADHEREPLRKACDTVQPGYLWTITTETTARDMDAVRAALGVDRIDFLGISYGTYLGAVYASLFPQRVDRMVLDSNVDPHWVWTEQFAQQQLAGKQRLDDLFGWIAQHDNLYHLGDSALRVYETWVRLVSAQGGGWYANLTPPPVSAADLPRELPAPLPALAREGVNAGAEELGKAQNLVRALASGGMSAQVPLVSATTVAAYTRGFWPSLAQAMAEANTQPGDLRRMRAIAGAATTDPTGRAVFAAITCNENAVPARLDAIGSAAAIVASGGNALDARADLVRSGLACADRDPVTTPVPIADHGLATAPLVLQSRNDAVTAYPGGPAMAAALRGHLITVDGGDHGTFGRGNAPLDDAVLHYLRTGEVGIDHVDQAPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCD1</accession>
    <name>A0A231HCD1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46426">
        <property type="protein sequence ID" value="OXR46426"/>
        <property type="gene ID" value="B7C42_01392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="18680" checksum="91E5FB0411CCF2A8" modified="2017-10-25" version="1">MSTRDPMAGAIEPNITTITTAPRAVTQEALVRCRRYRKENGLYGIVEPVRGRILLEIGPVGAITVPAALGAPIREYLSVRGHRGPIIGHPRSARWTFLTGHVDESATDAAIASDMFHRCAALVTPGTTIVLPSPADERTGYRVWIDSPHGDYRPELAEVLTATRQCRPDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCT4</accession>
    <name>A0A231HCT4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper transport protein YcnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycnJ_3</name>
        <name evidence="7" type="ORF">B7C42_01477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46507">
        <property type="protein sequence ID" value="OXR46507"/>
        <property type="gene ID" value="B7C42_01477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012489096" evidence="5">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="6">
        <location>
            <begin position="29"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="18231" checksum="5093967825EAD72D" modified="2017-10-25" version="1">MMRRVLFALVGALALSGATIAVAGPAAAHSTVVSTDPADGAKLATGPARVSITFNENLQPSFPSLTVVGPDGNLWSKGKPVVDGPTVSVEVGDLGPAGTYTMAYRVTSADGHPVSGTRTFELTTPGHGTPGAKADAKSSSGGDGDSGGVPLWVFIVAAVVLFGGGLAFALFGGRSRRPGSGGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCT5</accession>
    <name>A0A231HCT5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="6">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaX_1</name>
        <name evidence="6" type="ORF">B7C42_01771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46793">
        <property type="protein sequence ID" value="OXR46793"/>
        <property type="gene ID" value="B7C42_01771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="49"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="859"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1032" mass="105221" checksum="D9FE5819274F01EA" modified="2017-10-25" version="1">MREWFPVGVRRYPRAVALYRKYRPATFAEVVGQEHVTDPLSTALDTGRISHAYLFSGPRGCGKTSSARILARSLNCVEGPTSRPCGVCPSCVALAPGGPGNLDVIELDAASHGGVDDTRELRDRAFYAPAESRYRVFIVDEAHMVTTAGFNALLKIVEEPPAHLIFIFATTEPDKVLPTIRSRTHHYPFRLLPPATMRGLLGKICEQEQVQVEESVYPLVIRAGGGSPRDSLSVLDQLLAGAGAEGVTYPRALALLGVTDIALIDEAVDALAADDGAALFATIDRVVEAGHDPRRFAADLLERIRDLILLRAVPDAAERNLVTGPGDVIDRMSAQADRIGPATLARYAELLHEGLGEMRGATAPRLLLEVVCARMLLPSVSEAESAALQRLERLERRMESGGVPAAAPAATSQPSATPAASSSESAGGAARPSGETRRRGAEALAAMREKKSAPHPAQRAQSPAGPQSPAAPQTQNESEEQRPQGLSADPHAAAPAGSPSSDDRSASGAAGVPATGEQVSAPGSTVTAAAGSADRETGRPTSTGTDGDEKATATTSSGPTADNEGRGVGSEPSAGSPAGARSVADAERHDGAVESAPDRGAAAAGSGAVDRPSAADSGARPESSDVPHHEPDSAVSTAPRGGPESAGPDEGAEHGHEGRNAAASGSVVDGSEAGGPSGSAAHAARSFEPDRDSVPAGRPTTAEGANGPDAGPGPDSGGAESAAGDEAGAARVSTAESAAAAGPGTPDVPGADTVGHAADDAPAEPVASPAEAGSGDVLREIEAAWADIRAKARESSAALPALLSGAVGAVRVEGDTIVFAHPHAPLAQRLSIPQNIDAVRAAVHAVIGRQYGVRWEVGSGEAGGARAGGAASERPARGGGEPSAGRGGRGDNPGQSQPPRFVRPSQSQAQSAEGETRGGQTDTRGAAADRRDGQGQGQRREFRPPRGAGAADRTAPDDDIPPPEAPDLPDDPGPSDYSPVGYDGVPPALTPEEEQEMLAESARPVPPEQRRDPDEVALELLRTELGATHLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCY7</accession>
    <name>A0A231HCY7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46662">
        <property type="protein sequence ID" value="OXR46662"/>
        <property type="gene ID" value="B7C42_01637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="526" mass="57163" checksum="D185A44EB136E96D" modified="2017-10-25" version="1">MLTSAELAELFPDPDPAVFPTLTGRQMPEHVSGFPGDDHHGFDAIKLAGRIAIPPIMPWQRGNLRCLLRRDANGMWTHPDAVLIVPRQNGKSEILLLRCLYGLAVLGEKILYTVQRWDTGKDLHERLATMIASRSWLRKRLKKQPTLSQGRGTIEFTNGAKMVTSTRSADMGRGLTRIDLLIYDEAYNLDESASAAVDWAQMAAADPQTIYTSSAVNAFQHSKGFVLTDMRNEGLRGADRLYFAEYMAPAGMHWRSLPTWQYANPSWGVIANEAKIQKPLRKATTKAGIASFGVEALGRGIWPVRDEDKPALISADVWKTNKNPGATLIGPRAMAVDMTPDRKTVAITASQWTSEGRIHIDLGYHGPYSAQTVPYIVGKVLRLDPCVLVMDDQSPAASMIGDLEAAGLTVYSTNTGELAKSTGDFYDRALGALLNHTGDPDIADAVEGAVKRDLPGGGWAWDRKRAQDDISPLVAGSLSTWGLVKFGAQTAPVQKLVHRPLAPAAVMAPVSSRFGGRGLDLAAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDN5</accession>
    <name>A0A231HDN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46989">
        <property type="protein sequence ID" value="OXR46989"/>
        <property type="gene ID" value="B7C42_00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="90" mass="10419" checksum="40358C625D43A44F" modified="2017-10-25" version="1">MRTTPSSQTRLLLAQRIRRYHQNREVPRRTPKAPAPYTYSEELDMVRLAAIWLPFGGPPEEEIFTRFGISKVAFEARLEQVLTRSRSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDP4</accession>
    <name>A0A231HDP4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-aminoacylase</fullName>
            <ecNumber evidence="2">3.5.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dan_1</name>
        <name evidence="2" type="ORF">B7C42_00169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.81" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776970.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47050">
        <property type="protein sequence ID" value="OXR47050"/>
        <property type="gene ID" value="B7C42_00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047420">
        <property type="term" value="F:N-acyl-D-amino-acid deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="546" mass="58970" checksum="4A2A35EFE2EE1AB4" modified="2017-10-25" version="1">MDLLLRRAWLVDGSGAPGRAAEVAITGDRITAVGAPGELAPGPDTHVVDLDGLTLTPGFIDIHTHYDAQILWDGDLTPSCWHGVTTVIMGNCGFGVAPTRPPHREIIVRTLENVEGMSMEALNAGIDWCFETFPQYLDALERRRKRLNVGAFLGHTPLRLFVLGGAERAATPAELDTMRALVREAVTAGAVGLSTSRQPAHQGAFGRPVPSRFAEVDEVDALAAELGAVGKGILQVSIGPGMFVDQFSDLSVRYGIPVTWTALVARADKPGAAMRTVERGGALPGEVYPQIACRPIVMQVSLADPTPLGEIDEWKEVLARPRAERAELYRDAAWRERARPATLAAWAHRWPKVAVEETVADPDAVGIPLDRLAAERGTTAFDLMLDVALADGMSTRFRVVLDNDGDDEIGDLLADKRTILGLSDAGAHASQLCDACYSTHLLGHWVRERKAVALEDAVWRLTGQPAHAFRIRERGLIREGYFADLVAFDSATVGTTPIERVHDQPGGADRLVVRSTGVAHMWVNGVQTRRDGVDMADTAAGRLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDW2</accession>
    <name>A0A231HDW2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mlaE_1</name>
        <name evidence="3" type="ORF">B7C42_00051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46935">
        <property type="protein sequence ID" value="OXR46935"/>
        <property type="gene ID" value="B7C42_00051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="30923" checksum="B5F42A6979D0AB58" modified="2017-10-25" version="1">MTTTLRPPLTKPQQPASAPEPQLRRAPVLSRVGTQLKQRPARSLATIGRTAELTMEVLRYTFVDLVRMRLPMGEIVDQMWTLLKVTSLPALLMAIPVGAEVAVEVGGIMNQVGANSLAGAASGLGVVGQGAPMAAGLLMSGAAASAIASDLGARSIREEIDAMRVMGVDPVERLVMPRLLAMVAIAPILCIIIVAAGVFAGLIISANVNHVVPGSFWASFGAFATTTDLAFSVLKTLVFAVIVVLIASLRGLEAKGGPKGVANAVNASVVLSVFCIFVSNLLITQLQTMFFPDRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDZ6</accession>
    <name>A0A231HDZ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47104">
        <property type="protein sequence ID" value="OXR47104"/>
        <property type="gene ID" value="B7C42_00226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="229" mass="25141" checksum="5844C1A2135CADB4" modified="2017-10-25" version="1">MQALVRHVGRSEISMLKREIVRSAEGRSFSNAVGLLIGSEVAQDSVSLELVSDWHRPGAEAFICRFRLTWHDGCSDFLLKCPVSVAARPSDVIARWVDRSAHIQRYLPTATPKVYFSGGGTLCAEYIPYDFWELLGKAASIRERERMLASLAGMVSALAKGGFSPSDLSDLRSRGNDCVLVDVGDDLGASSPDRPYGDSCRTAVSALRRRPLSKRDVSYIVDHVQIHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE21</accession>
    <name>A0A231HE21_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent monooxygenase, reductase subunit HsaB</fullName>
            <ecNumber evidence="3">1.5.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hsaB_1</name>
        <name evidence="3" type="ORF">B7C42_00345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.36" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47223">
        <property type="protein sequence ID" value="OXR47223"/>
        <property type="gene ID" value="B7C42_00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036382">
        <property type="term" value="F:flavin reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="18218" checksum="32737DAA75F21AA6" modified="2017-10-25" version="1">MEPVVQVDEISEATFKSVLSRFCSGVTVITALSGDEPVGFSCQSFSSLSLDPPRVCFFPARTSTSWPRIREVGRFCVNILAHDQDEICRALARRGTDKFAGVDWELSGNGSPRLSGALASIDCELDREVDGGDHTIVIARVTALAEHSDQAPLLFYRSSFERLRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE87</accession>
    <name>A0A231HE87_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B7C42_00254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47132">
        <property type="protein sequence ID" value="OXR47132"/>
        <property type="gene ID" value="B7C42_00254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="89"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR47132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="734" mass="74708" checksum="8D184E8D1A01A32B" modified="2017-10-25" version="1">MAAMTETAIAPDRPADGVTTPGRGRTRSLPWEHLGLAALLGGTAIAYLWNLSANGWANSFYAAAVQSGAKSWKAFFFGSSDWGNSITVDKTPASLWPMEISARLFGMNSWSMLIPQVLIAVAAVALLRSTLRRTFGPGAGLLGGLALAVTPVATLMFRYNNPDALLVLLMIAAVWAMTRALEDGRWRWLLLCGGFVGLGFLAKQLQVLLVVPALALTYLFAGPPRLGKRLLQLLATSAALVVGAGWWVLVAQLWPADSRPYFGGSKHNSIIELTLGYNGLQRLGVDSGGGFGGPPGPGGRGHGPSFGSEAGITRLFSETVGGQIAWLIPAALILCVAAVVLCGKASRTDTQRAALLLWGGWALVTALVFSFMKGIFHQYYTVALAPGVAGAAAIGAVVLWRQRDRLGVRLVLAAAAALTTVTAVILLYRTPDFVPWLRWMVGVAGAVATVALVIPQPRRTAAWTAGLAVAVAIAAPVAYSIQTIASAHNGGIVLAGPKTSGGFGFGPGGPGGACGPAGPGVPGGTGSGPSTPAPGANGTRPGAPGQVPSAPPAGAESGCAAAGLGAVSADDGSDSAGAAQPPGQSGRVPRSGEPAATGPGAGQRPSTDRPSGPGMGERTNRQLIDLLKNNGAGYTWAAAAISSMGAADLQLDSGYAVMPIGGFGGGDPSPTLDQFRADVAQGRIHYFVGSERRGPGSGETSAASRIAQWVESTYAATDVGGTKVYDLTAPTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEQ1</accession>
    <name>A0A231HEQ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47461">
        <property type="protein sequence ID" value="OXR47461"/>
        <property type="gene ID" value="B7C42_00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="29297" checksum="5C9C1F7BB032F40D" modified="2017-10-25" version="1">MSSETDRPTADTPQPDRPESEPGLPAAAAPESATDRPENSAPTVAETPASPDTGETDGSDRTHAAAAAESSGSQPADSEPTERSDSEPTERGDSDSAPAAERASDDAGPQLHPALIATAVALPVALIVVVLVIAAMSRQSAGREPLALGSVPAPAAPSQDCTTLLAALPESLGDDYTKSELAQPAPPATAAWQLPGGGDPIVLRCGLDRPLEFTKASALQVVNGVNWFEVRDQTSGVTSGTWYAVDRGTYIAVTMPTKAGPSPLQEMSNTIGKSLPAKPLDPGPVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HES2</accession>
    <name>A0A231HES2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_00430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47308">
        <property type="protein sequence ID" value="OXR47308"/>
        <property type="gene ID" value="B7C42_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008661" description="TPM_phosphatase domain-containing protein" evidence="6">
        <location>
            <begin position="37"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="665" mass="70546" checksum="602A65D47BE3E2F1" modified="2017-10-25" version="1">MPPHSRPRRSQPPTLLAVLLSIVFGFVLGCCGPAVADEPMRLNEYVTDSAQVLDGPQRDTVRASVDALYTAHRERLWVVYVRDFGGVDPQTWGQRTATASGFGDRDVLLSIATSDRSYSFTGALPPSVSDAELNSLLTDQVEPRLHNGQWAEAAVAAADGLSTAMGDSGGVGIWPLIVITLIVLGVIGVVLGYSQLRRRARGRAETDAARAVDPTDTAALARLRTDLLESRSARVLVDTDNAIRASAEELRLATDEFGATATAPFAAALESAKRAMAHAFSIRQRLDDDIPETPDQRRDLLIELITTCGRADAELDDKVAEFDAMRNLLIDAPQRLDALTRDVVDLTVRLPRSEETLRQLLAAQPESVTAPVRDNVAMARERIGFAENTIEQGRLAAAEPVGRQGGVVAAIRGAEAAVTAARTLLDAVDTAETDITQARAGLPAAIDELGRDLETAQGLTEHGGPELAAAMSGARTAWEAARTTGDHDPLGTFHRAVAADTALDRAVAAAGERKLAAEQLRRRLDQAVIAAQSQVRAAADFIDTRRGGIDAAPRTRLAEAQRNLDRAQELSATDPQAALSSAQQAADLATRALHAAEADVREWQTRRPASGTSQAGAVLGGILIDSLLRGAGSGYRGRSMGGSGWGPASFGGSDSSRRISRGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HET4</accession>
    <name>A0A231HET4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator protein VraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vraR_1</name>
        <name evidence="5" type="ORF">B7C42_00507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503935.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47384">
        <property type="protein sequence ID" value="OXR47384"/>
        <property type="gene ID" value="B7C42_00507"/>
    </dbReference>
    <dbReference type="GeneID" id="66720785"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="23435" checksum="37BBED4FD187877C" modified="2017-10-25" version="1">MPITVLIADDQAMVRQGFGALLAAQPDISVIGDAANGAIAVAEAKRLRPDVVLMDVRMPEMNGLEAARAILAAGFDPPVRVLMLTTFDIDDYVYEALGLGASGFLLKDAPADELVRAVRVVAEGQALLAPTVTRRLIADVTRRRARPKPAPALNALTPREREVLELIAKGMSNTEIAEALFVAEQTVKTHVSKVFSKLDLRDRAQAVVIAYESGLVTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEY4</accession>
    <name>A0A231HEY4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Very short patch repair endonuclease</fullName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vsr_1</name>
        <name evidence="7" type="ORF">B7C42_00545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vsr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234851">
        <property type="entry name" value="V.Nce30759ORF546P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47422">
        <property type="protein sequence ID" value="OXR47422"/>
        <property type="gene ID" value="B7C42_00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018267">
        <property type="entry name" value="VSR_endonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="18938" checksum="C8B06BB6A90AB169" modified="2017-10-25" version="1">MTGSRSEDARRKAHDLGLYPAPLNEGRSRNMRANRRSDTKPEVALRSALHRLGYRYRKDHRLDLGSLKVRPDIVFTKRKVAVFVDGCFWHVCPEHGRQPTTNEWYWTPKLRRNIERDRAADAALTAAGWRVVRLWEHEHLDSAIATVTGALSDSLEHVSDTRGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF29</accession>
    <name>A0A231HF29_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA small subunit methyltransferase D</fullName>
            <ecNumber evidence="4">2.1.1.171</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsmD</name>
        <name evidence="4" type="ORF">B7C42_00597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.171" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779862.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47472">
        <property type="protein sequence ID" value="OXR47472"/>
        <property type="gene ID" value="B7C42_00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052913">
        <property type="term" value="F:16S rRNA (guanine(966)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="19411" checksum="8FDC60A70CA974AA" modified="2017-10-25" version="1">MTRIVAGTAGGRRLRVPPAGTRPTSDRVREALFNALAARLDFDGIRVLDLYAGSGALGLEALSRGASHALLVESDRKAAAVIRGNIADLAVPGAEMRPGTVASVLATAPAEPYDLVLSDPPYAVADAAVEADLRALSANGWLYGDALIVVERSARSPETAWPAGYSALKSRRYGETRVDLAEYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFD5</accession>
    <name>A0A231HFD5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011210678.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47528">
        <property type="protein sequence ID" value="OXR47528"/>
        <property type="gene ID" value="B7C42_00653"/>
    </dbReference>
    <dbReference type="GeneID" id="66720644"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="12250" checksum="AACB200C81284D64" modified="2017-10-25" version="1">MSAEDLEKYETEMELSLYREYKDIVGQFSYVVETERRFYLANSVELRPQNADGEVYFEVRMSDAWVWDMYRPARFVKHVRVITFKDVNIEELEKPDLRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFE1</accession>
    <name>A0A231HFE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulatory protein LiaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">liaR_1</name>
        <name evidence="4" type="ORF">B7C42_00795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779531.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47670">
        <property type="protein sequence ID" value="OXR47670"/>
        <property type="gene ID" value="B7C42_00795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="23183" checksum="89B552EEC8A6CA57" modified="2017-10-25" version="1">MTPSRRIGLVEDHESVALGLASMLAGESDLELVITAGTVSELLSAAPELDLVILDLRLADGSTPQSNVQALRDRGLEVLVFTGADNPFLVRSAARAGVLGVVRKSEDVQTVVAAVRAAASGEQVVTTDWAAAIDGDPQLPDVGLSPRQQEVLTLYASGEKASRVARLTGLSEQTVNDYLGRIRQKYADAGRPAPTKTDLYKRAVEDGWLPVPERNNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFE4</accession>
    <name>A0A231HFE4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779508.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47691">
        <property type="protein sequence ID" value="OXR47691"/>
        <property type="gene ID" value="B7C42_00816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="64" mass="7279" checksum="CEB550E1CAAC0F26" modified="2017-10-25" version="1">MRLTEFQELLHTEFGVARGDLLLADHVLPSMNGRTGAQAIEDGVDPREVWRALCAEFDVPKNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFH3</accession>
    <name>A0A231HFH3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4439 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47632">
        <property type="protein sequence ID" value="OXR47632"/>
        <property type="gene ID" value="B7C42_00757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029447">
        <property type="entry name" value="DUF4439"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14530">
        <property type="entry name" value="DUF4439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4439" evidence="1">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15062" checksum="B70C911A54E7C309" modified="2017-10-25" version="1">MSTDQQALLDALNAEYTAVYAYGLIAAYASPERAKVVAEFTATHRARRDATADALKAAGASVPAPAAAYTPPFPVDDPIPAAKLAVTVETDTAVAWRAVVEHSTTPDRRRTGIEALTECAIRLATWQSILGVNPATTPFPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG03</accession>
    <name>A0A231HG03_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Na(+)/H(+) antiporter subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mrpC_1</name>
        <name evidence="5" type="ORF">B7C42_00873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782797.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47748">
        <property type="protein sequence ID" value="OXR47748"/>
        <property type="gene ID" value="B7C42_00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12129" checksum="3A5E94C7881639D5" modified="2017-10-25" version="1">MSVFPYLVAAWVLLMGLFGVVRSRHLVHTVVCVSVTQSSTYVLLLAVGYQQKASAPIFGQANPPGSPVVDPVVQAMALTDIVVSATVSALLLALVIQVAKRHGTVVPDELHALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSJ4</accession>
    <name>A0A231GSJ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonine synthase</fullName>
            <ecNumber evidence="1">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrC_2</name>
        <name evidence="1" type="ORF">B7C42_08339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000208">
        <property type="protein sequence ID" value="OXR39593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39593">
        <property type="protein sequence ID" value="OXR39593"/>
        <property type="gene ID" value="B7C42_08339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="36" mass="3718" checksum="9A55D3053D8B6FEA" modified="2017-10-25" version="1">MTGNGLKDPDTALSGMPEVQAIQVDPVAVAHELELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTG4</accession>
    <name>A0A231GTG4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782344.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39914">
        <property type="protein sequence ID" value="OXR39914"/>
        <property type="gene ID" value="B7C42_08019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="28051" checksum="B2804CE068CA7D4C" modified="2017-10-25" version="1">MTQSDQPPASQVEPFDPDAVKRQIEENQRVEEEAFRPTDVLELLMLRVLGGWEHVVEDVRFLNYVVKDDPNAIVFPNAEDVAKDMRRNARKMNLRLPEGIWTPECDKVREIRNDLGHMLHIISVEGESPNRAVTFRRVPYRQPDEMTMDGNWARHRRITVTQTEQQLRDALKTMRDLKDAVFALRKFGIEFNHWPNDRPLDTTVRLLKWWMPEWDELGSRELTMGDVRVPGAEPRLISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTH7</accession>
    <name>A0A231GTH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000066">
        <property type="protein sequence ID" value="OXR39781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39781">
        <property type="protein sequence ID" value="OXR39781"/>
        <property type="gene ID" value="B7C42_08146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="34093" checksum="B50F567D00E0D377" modified="2017-10-25" version="1">MDTTFEQALREAMFRHLDELVRETGVVTRDQLWDFIVDGKVHRLIDRNRGIRNPADMNATLSILSDPKSSYSDEEVGESLFAYAYREGSINGDNRKLRRAYELDLPLILLRKIEDGLFVPVYPVYVVADDQEKRQFLIALDESLRRLPHPTHPDEIERRYIERVTKQRLHQPEFRARVLNAYKYQCTICNLKLGELLDAAHIIADGKPDGTPTIDNGLSMCKIHHAAYDSNFLGISPDYEVRINQKLMDDEDGPMLRHGLQEMNGRKLFVPSRRQHKPSRDRLAVRYDEFKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTN5</accession>
    <name>A0A231GTN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2,3-dimethylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="8">4.2.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dmdA_2</name>
        <name evidence="8" type="ORF">B7C42_07934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.85" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779238.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39983">
        <property type="protein sequence ID" value="OXR39983"/>
        <property type="gene ID" value="B7C42_07934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="7">
        <location>
            <begin position="525"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR39983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="666" mass="70503" checksum="D5FC7E3C92FEFCC7" modified="2017-10-25" version="1">MADNITHKILRRHLISGDLVPGTDITVAPDQILIEDATGTMAAMQFEELGLDSISVPLAVMYIDHNVLQIDDKNMQDHRYLRTFCERYGLRYSPAGHGISHYIHLERFSKPGELLLGADSHTSTAGAAAMFALGAGGLEVAVAMGGYGFEFPCPRVIGVELIGTVPNAVEPKDIVLEILRRYGVRGGRGAVFEFHGPGLEHLSTSGRATIANMIIETGATTAVFPSDEQTLAWLAQQGREKDFAPLVADDGATYDENITIDLSELVPLVAVPHSPGNVVPVADLPDTPVSQICVGSSVNSSYDDLATVAAALRGHTVHPRVQLTVTPGSRQILQTIIDSGVYQDLMQAGARMLEPVCGPCVGIGQAPLQGDASLRTFNRNFPGRSGTAEDRVYLCSPSTAAASALTGRITDPSSRPPIEPRPAREPDTALHSALITSPRPAEQRAAVLVERGPNLVSPPLPEPIGDDLQARVLIEVGDDISTGDMAPDGAIAMSVWSNIAACARFMFNRLDPGFHDRAQEWGGGVIIAGENYGQGSSREHAALIPSYLGVRVILARSYARIHRRNLIAAGIVPLVLPSGAAEFSVGQLCAFSGLRQALVGGESSICVEVAGHDVPIRAAIDLTEGERAILTDGGLLAHIRSGGRSPVSGSPLPSGVHERVNVKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTN8</accession>
    <name>A0A231GTN8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accA1_5</name>
        <name evidence="10" type="ORF">B7C42_07955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39976">
        <property type="protein sequence ID" value="OXR39976"/>
        <property type="gene ID" value="B7C42_07955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="12"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="131"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="589"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR39976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="674" mass="71905" checksum="8C2CE034066ED0DD" modified="2017-10-25" version="1">MSSTIPKTRRAAITKLLIANRGEIASRIIRTAREMDIATVALYSDADIDAPYVLQADESVHLPGTTPADTYLRADLVLDAARRTGATAVHPGYGFLSENEQFARDCAAAGVIFVGPSPEAIAAMGSKIEAKRMMAAAGVPVLPGATVENESDEDPERLRAAAEKIGFPILVKAAFGGGGRGMRIVSDQSELTEAVGSARREAASAFGNGTVFLEKFVQSPRHIEVQIFGDSYGTVVHLGERECSIQRRYQKIIEESPSTAVDDALRDELGRAAVAAGKALSYEGAGTVEFVMAQDGSFYFLEVNTRLQVEHPVTELVTGIDLVRGQLLVAAGAPLPEEMLDVTPQGHAMEVRLYAEDVAAGFIPVSGTLTTLEFADLPGIRVDAGFASGSQVSTYYDPMLAKVIGYGPDRDAACDRVARALQETRIHGVTTNRDLLIGILREPEFRSGAIDTGYLERHDPADLMIRRNGNDSVEQIHALVAALAAQADRRATSSVLPRLPSGFRTLPSAPQSVSFRAGEQVIDVEYLFGRTGLSVRVGDWRPESLEVNAASAELVDIAIDGVRRRYRITRSGAAYFVDSALGATELHEVERFPDPSDIQEAGSLLAPMPGTVVRVEVSEGQSVSAGDAVVVLEAMKMQHTIRTPSDGIVVKIPVAVAAQVDSGAVLAVVQDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTP1</accession>
    <name>A0A231GTP1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranial dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">geoB_8</name>
        <name evidence="5" type="ORF">B7C42_07941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.86" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779233.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39990">
        <property type="protein sequence ID" value="OXR39990"/>
        <property type="gene ID" value="B7C42_07941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="24"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="486" mass="51936" checksum="F82252B43CAC3210" modified="2017-10-25" version="1">MTGNTAAAQAQLRSYDKLFIGGRWVEPSSDAEIEVISPMTGEVIATVPEAREADVESAVAAARKAFDEGPWPRMTPAERAEVLVRIGDEIKKRIPVFAEIFAEEGGGTGPVATMVHENAIAMWNDAATLHTRFLFEEERSWEGGHGTLIREPIGVVAAIIPWNGPVALASIKVSAALAAGCTVVVKPAPEGPLTMMLFAEALEAAGLPEGVISVVPADREVGDYLVRHPGVDKISFTGSSAAGRKIMAAAAERVKRVTLELGGKSAAIIADDIAFETFVPELIFAGIGHSGQVCVALTRILVPRERQDELVEFMKTIMGSLKVGDPREPDTLIGPLAAERQQKRVLDYIEVGKQEGARLVLGGGKPAHLDSGWYVEPTLFADVSNDMRIAREEIFGPVLSVIPFDSIDEAVEIANDSDYGLSGAVFANDVELAESIARRVRTGQIAINQAAMCVVQPFGGYKQSGIGREGGIEGFEHYLETKLVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTU9</accession>
    <name>A0A231GTU9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40036">
        <property type="protein sequence ID" value="OXR40036"/>
        <property type="gene ID" value="B7C42_07881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="322" mass="34839" checksum="B23AD01774B93AAB" modified="2017-10-25" version="1">MTEPGPGRAARSIEQWQAKLLARIDRLAREYAMVQARGFTGYDGTDASPEQEWRSHLDALEAERETTEQLAIELGIPPQWVEHARTNGTEAAQHPSPTPEIANAVVDPATQADSSEASSASKQLFIDMAVVDVWHVHRMALLSAARDARLSAGRLGLGADPVADMQFHRNMALHHQRAAGLSDAAQLSEPEVAALWDSPQVRTARHQAAQQINRWDDLHLEFEWRRYTQPVTDPALPPYIPTDPATGAPTSRAQAPPPAPEELIGRAAAALGIDPERTDRLPIHHATAIDIALPATTDRDWQSGPAPAPPAAATGPDLGPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU11</accession>
    <name>A0A231GU11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40099">
        <property type="protein sequence ID" value="OXR40099"/>
        <property type="gene ID" value="B7C42_07854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16729" checksum="54BA1BA3D2A47B6E" modified="2017-10-25" version="1">MTQLPDDVEFEHLNAGQARELKDIVEDIYRRSYADAVASGELFDTPEQFMARFDAYTDPARSTGFELVVSRVRGNAIGQAWGWPLTPTTAWWDGLHLDSGDTDDFTAETGTRTFALSEIMVCQEHTGHGLAHALHDELLRKGLSDCRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUI3</accession>
    <name>A0A231GUI3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">hom</name>
        <name evidence="20" type="ORF">B7C42_07720</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042074.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40205">
        <property type="protein sequence ID" value="OXR40205"/>
        <property type="gene ID" value="B7C42_07720"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="387"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXR40205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="466" mass="48131" checksum="DDED6C215D6A8941" modified="2017-10-25" version="1">MTEATNQARGGAFGIEHPIGVAVLGMGNVGTEVVRILRDHADDLRSRVGAPVVLRGVAVRRLDVDRGIPAELLTTDAEALVARDDVDLVVEVMGGIDPARKLILAALNGGKSVVTANKALLADYTGELAAAAEGSRADLYFEAAVAGAIPVVRPLIQSMSGDRVNRVVGIVNGTTNFILSAMDETGADYADTLAEATRLGYAEADPTADVEGYDAAAKAAILASLAFHTRVTAADVYREGISKITAEDLETAAAVGCTVKLLAICERMPGGERLSLDGSAVAAPGDAGGSAAGKDRVSVRVYPALIPRRHPLSSVNGAFNAVVVEAENAGRLMFYGQGAGGAPTASAVMGDLVMAARNKFYGGRAPGESVYAELPIAPIGDIPTRYHVNLQVADRTGVLQAVSGKFAEHGVSISTVRQEGFDEGARLVVVTHHAPESALADTVTALAELESVTSVTSVLRLEGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUM5</accession>
    <name>A0A231GUM5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40330">
        <property type="protein sequence ID" value="OXR40330"/>
        <property type="gene ID" value="B7C42_07591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="779"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="845" mass="91875" checksum="6639B8077105F025" modified="2017-10-25" version="1">MTNPGGNARGAVPAPTHGFVGRKDELSLISALLISGPDRLITLIGPGGIGKTRLADEAARSAKAQGVRVYWVPLARLPVDAEFKQVEQATASAVISADFSNRRAGEALEAALRGTDSAGPSRRAVLVLDNGEHVLPALRHLIAQLLNTLPNLTILATSRSPIAWVDERLIPVPVLSPAESLTLFRQRCTLIGRSLEWNADDIAAATEICEHITHHPLHIRLAVGRLRYQGLADLCAELTGRADDKRLGWSTGARSGADPRHLAITNVIAWSYQLCSDKEKLLFTRLSAFAPGGRNPDDTGDTADVGADLDAIIAVCSDEHASTDPDQVSVSPHEIAGLLESLADKSLVSIHITPCGSRYSMLESLRVYAWDRLRDNDPGEPARLAKRHLAYYRDRVVDDARNWFSPRERALVMWARSSWSNIVAAIETSITMRGEAEAGLQICGGLITLRVPFVRGSIREIRGLAERCLDASETVSPQPVDLQLELRAALAWLAIRSGQSHEARRFLDEVIPCYLSEPDRAEWAEHPDRDFGLPAVIEITVGTALFLGAEDARAIAIIERAREKYHAADNPAEVFAHMFGALAAALLGSAPQAHTIARRAVGIAEASGASWATSWVKLSWAVTLTMHGDPHEATRVLRETLSYQMAFDDQWGAMWSVVLRTWALERMITGNDRDRDWQLAHEIAQTLGGAETLQAHLGVDITVMGSFAKMCRKAQVTARGILGDEHFAAETARGKQLNPHNNDVHRLALGELTLSVAPTPEEFAQRGGRTTQNTPLKFAATPWDRLSESEKAVARLAAAGLSNSAIARRRGTSTKTVDGQIAATLAKLGIPNRHHIAKHVPENHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUN7</accession>
    <name>A0A231GUN7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776361.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40191">
        <property type="protein sequence ID" value="OXR40191"/>
        <property type="gene ID" value="B7C42_07705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="9196" checksum="7FA5CE47D6B52E0E" modified="2017-10-25" version="1">MNDQSSEDQVFYVAPCGYENFGPMTCYPAIDPDGVPRLVIHVGVVGDQEILGLSLGVNTLRRLAEQLPQLEALATHIWVPISDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVH9</accession>
    <name>A0A231GVH9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-heme chloroperoxidase</fullName>
            <ecNumber evidence="3">1.11.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cpo_6</name>
        <name evidence="3" type="ORF">B7C42_07301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.10" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064902002.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40616">
        <property type="protein sequence ID" value="OXR40616"/>
        <property type="gene ID" value="B7C42_07301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016691">
        <property type="term" value="F:chloride peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="33"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="32735" checksum="211B94841BF92DB3" modified="2017-10-25" version="1">MTSTSVTVARPHRYVLKRTVDPTLQIAEWGSATPRVTIVLAHGLALSLESWEDVAQLIVAADPTVRVLAYDHRGHGESQVGAPATLEILADDLADVIDRLVPTGPIVVGGHSMGGMTLMALAERHPELVAARIAGVAFVATGAGDILRHRSRNRFWAWLLSLALAAAPFLVIPTHPLFVTRQLTRGVLFGAGSSSHDRNRAIRQLARSDPRTVAALTRSILSHHRYAMLERFDCRSVVLVGSRDQLTPVHHARAIRHRLSDSFLAVYPRAGHYLPYERCGEVAAHLLGLTLPSVATERDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVI6</accession>
    <name>A0A231GVI6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-ketosteroid-9-alpha-hydroxylase reductase subunit</fullName>
            <ecNumber evidence="7">1.17.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hmp_6</name>
        <name evidence="7" type="ORF">B7C42_07309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40624">
        <property type="protein sequence ID" value="OXR40624"/>
        <property type="gene ID" value="B7C42_07309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="259"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="38424" checksum="7BCACB36EEC12C08" modified="2017-10-25" version="1">MSSKRNIPCELTVSQVVQETADAISIWFDVPEGHWETFSYDPGQFLTLRIPGVDEGSSVARCYSLSSSPHAEDTLAVTVKRTADGYASNWLCDHAVPGMKMTVLPPSGHFTAKDLDADMILFAAGSGITPIISIIKSSLLEGGGHLILFYANQNAESAIFYEELRHLANQFPERFSLIEWLEIRQGLPDRQTVADLCAEHRNRAFFLCGPAKFMDLVTDAAHHADVPHRNLHREVFQSLRTDPFDVDNTVSESMTTERAHLVVYLDGERAELDWPKDISLVDILLKEGFSPPYSCREGGCGACLCRVVDGDVEMKVNDVLVEDDIEEGDRLACQSVPVTDSVTVTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVU0</accession>
    <name>A0A231GVU0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40601">
        <property type="protein sequence ID" value="OXR40601"/>
        <property type="gene ID" value="B7C42_07286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="17857" checksum="C15F3ED89D1B54C7" modified="2017-10-25" version="1">MMVDRSWWVRLLGADGPAAVICVRLLVGVVFLSEGIQKFVYPHQLGPGRFTKIGIPAATFFADLDGVVEIGCGSLLIVGLLTRLAAVPLLIDICGAIGLTKIRELQPGGFLGVHGFWGMAHDARADWSMLLGLIFLLWVGPGRWSLDHALTRRVGASGGRREEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVU4</accession>
    <name>A0A231GVU4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40716">
        <property type="protein sequence ID" value="OXR40716"/>
        <property type="gene ID" value="B7C42_07140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="25618" checksum="761D58E1F29F8524" modified="2017-10-25" version="1">MTRPEETLVDPQAEDPMPGLVSFIAGGNFVSPAYYISTTIKTVVGFDVYGWAGEKVNGDWEAVAKAAGAAGNLSRFNSAYAESINTQWQQTAGATWHGHAAESSETYFKHLAACVEFQVRPLEEIERQLTNISTGMRELGRRVGDFLQDISDLALLWLASQAAEAVLASSLVGAPAAAAQAAVSAAYLVQIVAKVGQLIKLVTTAYKAIYGMIGLLNALSSQTTPENLPPLPNSSYDHPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVV5</accession>
    <name>A0A231GVV5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pyrG_1</name>
        <name evidence="9" type="synonym">pyrG</name>
        <name evidence="12" type="ORF">B7C42_07260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40702">
        <property type="protein sequence ID" value="OXR40702"/>
        <property type="gene ID" value="B7C42_07260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="17"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="320"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="401"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="206"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR40702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="578" mass="62791" checksum="5E4DEE5BB1A21DBA" modified="2017-10-25" version="1">MSQSRIPARSPHQTATKHIFVSGGVASSLGKGLTASSLGQLLTARGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRDLSGYANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKNRILAMSGPDLQGQTPDVVITEIGGTVGDIESQPFLEAARQIRHEVGRDNCFFLHVTLVPYLAPSGELKTKPTQHSVAALRNIGIQPDALILRCDREVPQGLKNKIALMCDVDVDACISTPDAPSIYDIPKVLHREGLDAYVVRKLGLPFRDVDWTVWGDLLDRVHNPREEVTVALVGKYVDLPDAYLSVTEALRAGGFAAKAKVNIRWVQSDECETPEGAQHHLGDVDAVLIPGGFGIRGIEGKVGAIRFARTRSIPLLGLCLGLQCVVIEAARSVGLEDANSAEFEPETTHPVISTMADQAQAVAGEADLGGTMRLGAYPAVLEKGSVVAQAYGTTEVSERHRHRYEVNNAYRDKIGQSGLRFSGTSPDGHLVEFVELPANVHPYFVATQAHPELKSRPTRPHPLFAGLVDAALKYKGAERLPVEIYGEEADEAERVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVV8</accession>
    <name>A0A231GVV8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hsdR_1</name>
        <name evidence="13" type="ORF">B7C42_07160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234855">
        <property type="entry name" value="Nce30759ORF7162P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40736">
        <property type="protein sequence ID" value="OXR40736"/>
        <property type="gene ID" value="B7C42_07160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="279"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="922"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR40736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118006" checksum="E724012D13FD959B" modified="2017-10-25" version="1">MSPVHDEHTFVGEIVAAMVENGWRQANPHEYRPELGLDMGELLAFIESTQHDEWEDLLGAYGGDSDEAQRGFARAVDREVGSNGLVEVLRSGVRDRGVRIQVAYFKPNLVTSEDALAEYKENRLTVVRELPYATKQADAGHRLDLALLLNGIPIATAELKNPLTGQNVEHAKNQYRTERDATELIFTRRVIANFAVDPDLVFVTTQLRGAKTRFLPFNTGSEGAGKPGGAGNPTPIESGKYPTSYLWEQVWHPDHWLDMLERFVHIHESKGPGGRGAKTIIFPRFHQWDAVKKLTAHAATHGAGHDYLVMHSAGSGKSNTIGWLAHRLSDLHTPTDPSKLDPDARAAGLKPGTPVFDKTIIITDRRNLDSQLSETVGGFERVDGLVVKIDDKQGAKSEKLAKALSQEEGKIITVTLHTFPALLDYLRRSPTELLGGRFAIIVDEAHSSQSGDAAKAVRSALRDLGLDPEDEDAGAAELTLDERLKQKAAERGKARNISYFAFTATPKSKTLENFGTLVGQKYEPFHTYSMRQAIDEGFILDPLRNYVTYKTFYRLVNDNPSDYEVPERKANALLARFAVMHPHTVDQHAQVIVEHFVAHTRPRLGGRAKSMVVTASRHSAVAMSRAIKRYIEEREYDKLYPDIGVLVAFSGALDYEGEETTEPKENDGLPESQLPKAFGYTRADDVATRVGGKGQKEYRILVVAEKYQTGFDQPLLTTMYVNKTLAGIAAVQTLSRLNRTHERKSQQDLVVLDFVNDAEKIRDAFRPYYEEAHTLPTDPNLLYLAQDRVMSAQLLTTKEMREFANAYLLAEDQAAGSQAKWQKLHAELYRLLAPAVERFTELLDSDEEDDVEKAENFRADLNDYVRKYGFLAQIVPYQDSDLELLHLYGRHLLNRLPRRSDGGVDIGDVDLSHMRLVKTGEHDIGLNPEGPSELRGFGDGSAAAQEPEKSPLSELIDEFNKRHGTSFTEEDAAKPFNEAAAEPHVQLAAVANHSEEEFGRVFDPVFEEKMMDHYETISNLGKRYFSKSDPAFKETLNRQARSAAWRMIRRQQGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVX7</accession>
    <name>A0A231GVX7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40725">
        <property type="protein sequence ID" value="OXR40725"/>
        <property type="gene ID" value="B7C42_07149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="16194" checksum="93D1FDEB4CAFB88C" modified="2017-10-25" version="1">MSEQGGWDEFVVALCDLAVKYDADTFLHESLVLLTARAIPPGDKAGRIAVTRFDDEAARIETGWCFNIVTDYVAEDTSQPVPALRLVEAICRGDAEEHCLIDEDGRWVGVLLNAWGQGGNWMSGDHDRLEKRATRRFPRWNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW28</accession>
    <name>A0A231GW28_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776906.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40829">
        <property type="protein sequence ID" value="OXR40829"/>
        <property type="gene ID" value="B7C42_07113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="296"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="431" mass="45826" checksum="26A964DD8C3A12C0" modified="2017-10-25" version="1">MGSQELAARWADALDGVVAPTLTRTEIEALLAGLCEELLGVLRGTVGLDAARLAASSLVAANYRDDAAVSRSVLVICRDMVAEVCPDTGDPGYETVRDRAVTVAAEFAAGFTAALRGAALAEQETTLSAALAAVREEQARRQLSEARFGAIFAGASVGIGTIDAETGRVRDVNAAFAEMLGVPIDLIIGRSVAAVLGAENIGDAYTHFQQLLTGGLDRFRMETSLTRPDGHHSVIDLSMSVVRDARGSVRFLIGVAVDITERKALADRLWYEAHHDDLTGLANRLLFFDRLTRAEPPIGLCYLDLDGFKEINDDYGHTIGDRVLRTVAERLGAAAEPDGLAARIGGDEFIVLIEQCADEARLVDMSARLLAALGEPVEVAGGSITVGASIGTALVTRQPEAVDDLMHAVDTAMYRNKSARQRSGSRSRLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW29</accession>
    <name>A0A231GW29_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40833">
        <property type="protein sequence ID" value="OXR40833"/>
        <property type="gene ID" value="B7C42_07117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="747"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="831" mass="90837" checksum="AF99542C01F4B4FB" modified="2017-10-25" version="1">MTTPWISQFVGRTAELRSIAELLDPGGPRLITLLGPGGIGKTTLATEALRRSQRPGRDQVLWVRLARLETGAGVEAVAEEIVRTVAPTDPTGRSAEDCLLDAFASLGPVRTILVLDNCEHVLHPVARLIVELLSVNPDVTVVATSREPIGWTDERLVPVPPLTNDHALELFRRRAELTGRPIGAEPATLELAARICRRVDNNPLFIRLAAARLRYRPVAEVLRDLTGTDSDGWMRWSSGVRAGADERHRNVGDVIAWSYGLCTDAERLLLDRMSVFAAGFDPGDEETRSGGIEYSAVAQVCADEALPEPVIAATLERLVERSLVSTRMTATSVRYFLPESVRAFARARLQERPDGSAAPSGVPARHRRYFRDKVVAGQAMWYGPDEMEWIDWVRAAWNDVLLAVETSLADPDEAVIGLEIATVVMALRVPFLTGTNRAVTGLTERALAVIGDDPALSSLRISAKALIGWIAVWQGRFDYTSRLLDECAAECLTDPVLREEWREHTADDIGLPAQVEFTWGLELFLVRLDLRAIEVLSRARRKFAAVGDRGGTQRSDLFTVLAAASLATPEVAGRVVRRHLHDAAKTDAPWAVSWAEFAELVATIRHGDPADAVRRGRAAVAAHLDRGDTWTAGWIIHFCTVALAAILSRRIESGARPGELDAAAREIAYLQGGTAALHRSMGIASDRVPLVAEGSLAARTAATAVLGAQRYAAAVRRGGRMRPQENELQRYFLGRLEIVEDADVGPDDARWQELSPAEREIAILVAAGWTNSAVAVRRGTSVRTVDAQVATIRRKLAAADRSAIIHRIPGGLRERVRAESRQPPGRLRRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW42</accession>
    <name>A0A231GW42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40834">
        <property type="protein sequence ID" value="OXR40834"/>
        <property type="gene ID" value="B7C42_07118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="375"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="457" mass="49970" checksum="4B4BF8A05A92234E" modified="2017-10-25" version="1">MFQRSRIGVLPATSSEFVGRSAQRERITALIARGARLITLTGPGGIGKTRLAIETLRRDVGLPTRWLALAELDAETAIAELRDFAPRPDGAPHVLVLDSCDRLVTALAPELADLLEADPALTLVATSREPIGWIDEQLVPVPSLDPAQALRLLRIRMELTGRTAGGADDDILRRICAHMSHNPFGLRLAAIRLRHNPPTTVLQEVSGDAYDRRLQWSDSARVGVEARHRDIGANIAWSTSRCTPTESLLLQRMSVFPGGSAGGGADREAIVAICADDALPAAAIETTLDRLVERSLVIVRLTATSARWYLTECVRLVARAELHRRDPVEANRLAARHLQLRRLEVRRAEGAALPQQPCVATAQPPVAAVAAPRPESDRWESLSRAEREVAVLAAAGWPNSAIAVRRHSSVRTVDAQVAMVRQKLQITSRGQIARHLPAEARERMRSEARARRETARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWA6</accession>
    <name>A0A231GWA6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40855">
        <property type="protein sequence ID" value="OXR40855"/>
        <property type="gene ID" value="B7C42_06990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="370" mass="41636" checksum="2A4F3AD75B029CC0" modified="2017-10-25" version="1">MLTPQDELLCHQLPTTFDHVLQSDLRWTERVVLYGFDTTGTVSVMTGMARYPNRNVIDAYAMVTVGDKAHVVRLSRELNTGGGDLGAWEVGPFRYEVTEALRGVRATLGDNDFGVRLELNFRGDFPAYEQEPAFFRTRGRVREDARRYYQNGTISGWIEAGGVRYEIDPDTWWFGRDHSWGTRHGGGGGSLSEGEGLQPPEIPDGVLYYMGIFQFHDELVHFAKRETADGQRWQFEGTVIPPLGTGAAPAPILDADHDLRFREDFRIVSGGSFTTRDADGSEREFTITPISSFWPGLAGYDHYRGYASGIWKGPSWADGFTVDLTDTDEMRQVSMLTETFCRVETDGKVGYGLVEMVFMGRNTRYGYQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX72</accession>
    <name>A0A231GX72_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amino acid permease YhdG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhdG_4</name>
        <name evidence="7" type="ORF">B7C42_06618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41220">
        <property type="protein sequence ID" value="OXR41220"/>
        <property type="gene ID" value="B7C42_06618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="484" mass="49985" checksum="734F1CE971A2F9AE" modified="2017-10-25" version="1">MSHEPIEPTAPALSGANSGEANGGRLSRSALVSLSLATFFPAVSLAMVPFLVFTTSGTSAWQASLLATIAVICIGRAVIVFARRYVASGSLYSYVGEVFGPWARYVTAASLFAGFVVGIAALAAVVGVFTGSFLYARGLHEALHFNTQVIVFGAALLVAAFVAFRGLDTSVIIAVVLTVLALPLIIVITVASAMHTGLDLSRQFNFTDFHLGHTLQGIAVGAAFLVGFESCAALATETRDPKRNVPMAIMAVPVVLGGLFPIVTILQVPGLTAASDELAAGVSAPAALAIQAGLGTTVASATDLVLAVASFASLVGFINYGGRFAMALAEGGLLPAALARLHPKHGSPYIAVGLMALLSFTTIAGMLLWTGDIVSAYTPNATLLVYLWVIPYIIICVGAIVLTIRLGEFRPLLWIAAAIGAATMIWAYINGIINPPAPPADSMIWVAGIAIVAVLAVFGVTPRRAHRPNSPDTDETGASVTQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXT3</accession>
    <name>A0A231GXT3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780440.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41382">
        <property type="protein sequence ID" value="OXR41382"/>
        <property type="gene ID" value="B7C42_06525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="26427" checksum="19C3580CAB108E07" modified="2017-10-25" version="1">MSKQPGATLTPLAISVLALLEEDRMHPYEMYQLLLKRRKDNLLKIRPGSLYHTVTRLAEQGLVQAEGTERSGNRPERTTYRITEAGTAALRTRIADIVRQPIREYPIFPIGLAEAHNLPVDEVIALITERIGWLDNDITELDAIREWARSREVPRRYWMVIDYLVGLARHEVTWLRALIEELRDGSLPWLEFDEGGTRCPERTGDLGHDWGAALTDDVLAELRRGGATTAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ02</accession>
    <name>A0A231GZ02_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41839">
        <property type="protein sequence ID" value="OXR41839"/>
        <property type="gene ID" value="B7C42_06181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="419" mass="41769" checksum="502027FB0ED9C950" modified="2017-10-25" version="1">MLVFGYSRNCRNSILGHVFGGADGVLTVSRRPAHPEEESDSGMRTVDNDNRVGEPRARVPRWCGRPPAEPPAERFRRRFSRAGVVAALMSTAIGITLVVRADSGPPVRVNDSRAYSGERTVQTFDGGASRGDIAAANTSTAFDASSELPVPVDVAGDADAAADPGTAPPAADPTDPGSGPATATESAPPTTTDPSPPSSTGGSLDASFSATASLSIQLMPGVPDSGLVVPPPISTVPTTPAQTSTVTVTADPTTATTTLPSTTPTTPTTTAPTTTAPTTTALTTTVPATAAPTTTRPTTTPPAPTTTAPTTTVPATAAPTTTRPTITLPAPTDTATAPAGASAKTTRVSPRTTTNTGAASAAPSPEAVTTSGSPTTPATRSTTTAAPKTTAPPPRPKSARPTAPSLAHPPATSPKVAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ44</accession>
    <name>A0A231GZ44_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane mycolic acid synthase 1</fullName>
            <ecNumber evidence="3">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cmaA1_3</name>
        <name evidence="3" type="ORF">B7C42_06212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41870">
        <property type="protein sequence ID" value="OXR41870"/>
        <property type="gene ID" value="B7C42_06212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="33"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="68"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="94"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="34181" checksum="7BF12BD2FAEFC408" modified="2017-10-25" version="1">MMTVTGPIPGAIKSRDELPDEFFALFLDPTRTYSCALWTHPDDTLERAQSAKIDLTLAKCDLRPGMTLLDVGCGWGSIMLRAMDTYGANAIGLTGNRHQYRYIRDRLVDRLIRGRPYGGVRRQGWEEFDRHPDRIVCIGRLEQLHPHRYPDFFDFAYRILPENGVLLVQTVVTSGRDRSDAHQIRFADTDSVLSPRTIFPIDRLPPPTGRNPTGLTEYAQDAGFTVTGTDRFGPHYTTTLQCWASALREHRDRAIELAGHDTYNAYINQMTAYADYFRSGHLDLMQLTCTKTATPHPREAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ65</accession>
    <name>A0A231GZ65_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41904">
        <property type="protein sequence ID" value="OXR41904"/>
        <property type="gene ID" value="B7C42_05888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="29099" checksum="DECF3AAB87BB65C6" modified="2017-10-25" version="1">MGRLEGKVAFITGVARGQGRSHAVRLAQEGAAIVGMDICAQIDSVFYPMATEEDLAETIRLVKEAGGRIVTSIGDVRNRVDVQRAYDAGVEQFGFVDVVVANAGIMPVIDQGVEPQAWHDAVDTMLTGVWHTLEAAVAPMIERGKGGSITITSSAAGLTSMGLNTFPGQAGYSAAKHGVVGLMRLYSKQLAKHSIRVNTIHPTGVNTPMVANAEYGAFVNSHPEVMNDEAYKNPMPVELIEAVDVSNALAFLASDEARYITGVTLPVDAGYNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ98</accession>
    <name>A0A231GZ98_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Quaternary ammonium compound-resistance protein SugE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sugE_2</name>
        <name evidence="8" type="ORF">B7C42_05917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779019.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41933">
        <property type="protein sequence ID" value="OXR41933"/>
        <property type="gene ID" value="B7C42_05917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11071" checksum="A383AF925B762D22" modified="2017-10-25" version="1">MNWLVLSLAGVVEIAWSQSIKPTQNFTKPLPTLLCFVLAAIAVYLLSHAMQSLPVGTAYAIFTGIGAVGAIALGIVVQKDPVSAGRMLALSLIIGGIILARLTNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZF5</accession>
    <name>A0A231GZF5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine monooxygenase RutA</fullName>
            <ecNumber evidence="2">1.14.99.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rutA_5</name>
        <name evidence="2" type="ORF">B7C42_05977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.46" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41993">
        <property type="protein sequence ID" value="OXR41993"/>
        <property type="gene ID" value="B7C42_05977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="295" mass="30976" checksum="DCDB4E59FC0B4B8B" modified="2017-10-25" version="1">MKIGVALPQMAPGYGPGTTVDWARRIDAGPFSSVSVGERVTFSNPEMVATLGACAAVTERVQVLANLWVLPQHPTAMVAQQIGTLDQLANGRLEVAVGVGGREHDYRALGADFTRRHQQLDDKVAELKSLLAGEPPFEGADPVGPACVQPGGPIILAGSMGPKAMRRAARWADGISGFSIAGDAEEIAKVSDRADRCWAEAGRKTKPRKVSGCFTALGVPDASEALRSFTARYLGFLGPDLAGMIAASARASNPEVLADILDGAERAGCDEFILVPAVTDLKFLEVASEVVAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZJ7</accession>
    <name>A0A231GZJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42005">
        <property type="protein sequence ID" value="OXR42005"/>
        <property type="gene ID" value="B7C42_05989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="10429" checksum="3D44763EFA0A353B" modified="2017-10-25" version="1">MDDRTRCTAVNGLEAEWTMQNYRHIEIRRGRDPATGDVIEFAPGTDLAAAREQTSRHWAAVWDRVAHEMWTAWIPGQRNSESATPMTRFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZQ0</accession>
    <name>A0A231GZQ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782823.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42083">
        <property type="protein sequence ID" value="OXR42083"/>
        <property type="gene ID" value="B7C42_05682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="13810" checksum="BC2B08BF67B3EA41" modified="2017-10-25" version="1">MFEPFPGHYVWNLSINLALAQGAAIGEIDEGCRPLIGAEPDSEQLFASLCAIADRVRRQADADVTAGHALSAATRYRRASIYYLKIEAPLLVVHGGNDRQVSPAMAQICRPQSTSSRTGLLIGSAPDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZV6</accession>
    <name>A0A231GZV6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaerobic sulfite reductase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asrB</name>
        <name evidence="3" type="ORF">B7C42_05752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42153">
        <property type="protein sequence ID" value="OXR42153"/>
        <property type="gene ID" value="B7C42_05752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="284" mass="30472" checksum="293DABC865949503" modified="2017-10-25" version="1">MSSAPAAAAVTDPDTMLRYRVVDRIAQTADTATLILAPIDGAAQRFRAGQFMMLYRFGVGEIAISISGDPYASGDFLEHTIRSVGAVSAALYDAPPGAVIGVRGPFGTGWDLDSAVGRDLVVVGGGVGVAPLRPIVLEALARRSEYGRIMLITGARTPGEILFRHDQRAWRADGRLELYQTVDHPAPGWTGRVGFVTEPLRTLVVDPARTTAFLCGPEPMMRFCAQTLIRHGIARGDIRLSMERNMQCGVGRCGHCQLGPLLICRDGPVVDYAVAGPLMTVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H010</accession>
    <name>A0A231H010_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42203">
        <property type="protein sequence ID" value="OXR42203"/>
        <property type="gene ID" value="B7C42_05802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7645" checksum="0A6DA9350A228B25" modified="2017-10-25" version="1">MTAFPAGSDADHAEQQALADIRDHDTGPDFTRVHPLAERIRDAFDTADRIDQSWTLPHADDDYDCLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H035</accession>
    <name>A0A231H035_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42227">
        <property type="protein sequence ID" value="OXR42227"/>
        <property type="gene ID" value="B7C42_05826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="36754" checksum="E0172B7AB2D3B2D5" modified="2017-10-25" version="1">MPSRSVHFVGSFPAANTDEAMRAMADSAGPLLHTLPTGETRRYEYYVRLILEDLVAQGALEVTRAGEWRTRRDRPRYRVPEARTAAGDGMHLGYSGEAAEALPIFSAVRAELGRPELALQIGMPTDLTLAFVALGPKGIRSERAAFTEATVREIAAVTRAGGDDVVIQLEATAELVAMALTQPAHRMVERLLGSGRGIAALAAAAPEGTRIGVHLCLGSLHNKGVPLRTARPFVDLANSVARQWPSGRTLEYVHVPFAAGDRPPAAESRFYAPLADLSLPAGTRFYAGVVHDVPTEDEQRKTLHTIENALGRRVDGVACACGLGRRPRAVADALMARAVTLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0G8</accession>
    <name>A0A231H0G8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42375">
        <property type="protein sequence ID" value="OXR42375"/>
        <property type="gene ID" value="B7C42_05574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="98" mass="11006" checksum="0109B8B0E714FADB" modified="2017-10-25" version="1">MTPAHPIALGWVHPDSTAPDWDTAQVRRLATRLGYRLVWPPESSHIPLPDQVRATGAEAVIAPSTQHFDFLTLNALMMIADVETVHPRLSFARWATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0V6</accession>
    <name>A0A231H0V6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol dimannoside mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.345</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pimC</name>
        <name evidence="4" type="ORF">B7C42_05638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.345" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780724.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42437">
        <property type="protein sequence ID" value="OXR42437"/>
        <property type="gene ID" value="B7C42_05638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043750">
        <property type="term" value="F:phosphatidylinositol alpha-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="375" mass="39966" checksum="2BEC4E59DAC95B46" modified="2017-10-25" version="1">MRIAQLANFYGPRSGGLRTALHHLGAGYVAAGHEVVLIVPGARRGEEMLPNGVVRMTVPAVGIPWTGGYRAADPRRVADLLAGLAPDALEVSDRLTLRGFGRWARRRDIASVMISHERLDRLLGQVLPTSVARRAADVANRRTAADYDMVVCTTAFARAEFDRIDAPNVALVPLGVDLELFAPHRHDRALRARLGGSHLVVHCGRLSVEKRVDRSIEAVDHLRRGGVNVRLVVAGDGPRRDALVRQARGVAALPDGRPGVHFAGFIDDRTHLATLLASADISLAPGPHETFGLAALEALAAGTPVVASRSSALADIVTAECGAVAADHPSAFAEAVTDVLARPAAQRRRAARSRAEQFPWPVAVSGMLSVLRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H162</accession>
    <name>A0A231H162_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Topoisom_I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_05307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42531">
        <property type="protein sequence ID" value="OXR42531"/>
        <property type="gene ID" value="B7C42_05307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topoisom_I" evidence="5">
        <location>
            <begin position="81"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="339" mass="38414" checksum="38567D7CCE3903EF" modified="2017-10-25" version="1">MRLRRSTPYGAGIRRVRRGRGFSYTDENGVPVTDPEVTQRIDALVIPPAWRKVWICPHAQGHIQAVGVDAAGRRQYLYHEQWRRERDEEKFDRMLEVAAQLPNLREQVSADLRRSGSDRRRVEAVAIGLLDRGVFRIGGEEYAEENGTRGVATLLREQVRVSGEEMRFDYVAKGGIRRQVRIVEPDLARAVRSLRRNRSPSGRLLVYREHRHSSELRSGDINARFKALVGDDHSAKDFRTWQATVLAAAGLAATECPNSQRRRNSAVRQVMTEVAEALGNTPTVARNSYVDPRVIVAWERGRTIAAASRRARRAPSEDERRAIVERAVLRLLRSAANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H163</accession>
    <name>A0A231H163_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_23</name>
        <name evidence="1" type="ORF">B7C42_05349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42572">
        <property type="protein sequence ID" value="OXR42572"/>
        <property type="gene ID" value="B7C42_05349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="26550" checksum="D74CE2CE30D8FC48" modified="2017-10-25" version="1">MPNADLTGRTAIVTGASRGIGLATAQALAAAGADVVLTSRDQESADAAAAQVQGSALGIAAHAVDEDAARACIDRTLERFGSVDILVNNAGTNPAFGPVIDQDHGRFAKIFDVNLWAPILWTSLVTKAWMGEHGGAVVNTASIGGMGFEANLGLYNASKAALIHLTKQMALELSPRVRVNAVAPGVVRTKLAEALWREHENLVADATALDRIGEPDDIGSAIAFLVSDAAQWITGEVMVIDGGQRLGHPAAFRTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1H1</accession>
    <name>A0A231H1H1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pncB1</name>
        <name evidence="11" type="ORF">B7C42_05031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42695">
        <property type="protein sequence ID" value="OXR42695"/>
        <property type="gene ID" value="B7C42_05031"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="155"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR42695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="437" mass="46153" checksum="082E8CA867375899" modified="2017-10-25" version="1">MDTSAAAASTALLTDQYELTMLAAALADGSAQRQCTFEVFARRLPHGRRYGVVAGTDRLLTALRDFRFGEAELAVAARFLDARTLEWLRDLRFTGDIDGYLEGDLYFPGSPILSVRGSFAECVVLETLILSILNHDSAIAAAAARMVSAAAGRRMIEMGSRRTHELAAPACARAAYLAGFDATSNLEAVRRYGIPGAGTSAHAFTLLHSGPDGQHEAAAFRSQVDALGIGTTLLVDTFDITAGVARAIEVAGPELGGVRIDSGDLGVLARQVRDQLDALGATKTRIVVSGDLDEYAIAALRAEPVDAYGVGTSLVTGSGAPTAGMVYKLVEVEGVPVAKRSSHKQSRGGTKRAVRLSRDTGTIVEEIVYPATAQRPTGNGYDVRDLLVPLIRKGEPAAEVPDLAHSRDLVARGLISLPWEGLKLSAGEPAVPTTFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1L9</accession>
    <name>A0A231H1L9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42707">
        <property type="protein sequence ID" value="OXR42707"/>
        <property type="gene ID" value="B7C42_05043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15962" checksum="04F8465159399FC9" modified="2017-10-25" version="1">MVVAALACLGLGWWQWGRFESSSGTAQNLGYALQWPLFAGFVVFAYFRFVRLERDTAAQHTEAPETAEPSRPADSAAPARRRVERAAPREIPAGILPERPTAARDDDPVLAEYNKYLADLHAQDVRERMHAVGLDGPDTERRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H279</accession>
    <name>A0A231H279_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42950">
        <property type="protein sequence ID" value="OXR42950"/>
        <property type="gene ID" value="B7C42_04836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="36056" checksum="B8E0E765A29D16DC" modified="2017-10-25" version="1">MISGNLLCDGLRQVTMIFMAATGGCGNVGEMGRVNGETAGGEGTSERVDGPALAAVVDTERYPLDAPGSARWVEVVRRARQDLAADGCTVLPGFVRPDLLATLREEGAELAPHAYYTVEKVNAYNIPLDSDLPPDHPATIVLERGNAFVARDLIPRTAVIQVLYTSATFQRLVAECFGLPQLHEYTDPLAGLCLNVVAPGMSHPWHFDTNEFTVSMLTQEPDAGGVFEYCPRIRTPESENLADVRSVLTGSGEPLIRRLTLRPGDLQLFQGRFSLHRVSPVEGATQRHSAIFAYSDRPGIVGAVERTRQLFGRVLPDHLAAAGNAVRGDRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2A8</accession>
    <name>A0A231H2A8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mercuric resistance operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">merR</name>
        <name evidence="2" type="ORF">B7C42_04864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42978">
        <property type="protein sequence ID" value="OXR42978"/>
        <property type="gene ID" value="B7C42_04864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="14854" checksum="24AA3A880E137DD8" modified="2017-10-25" version="1">MSALRTSELAAAAGVNTQTLRYYERRGLLAEPQRTLGGHRLYPEEAVTVLRVIKAAQRLGFSLDEVADLLPGTGHHRRDAGLRTRARAKLAEVDAKLAELGAVRDTLRAALAAGCEDLLVCSEMPSCPVPFGISADSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2H7</accession>
    <name>A0A231H2H7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_20</name>
        <name evidence="1" type="ORF">B7C42_04894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43008">
        <property type="protein sequence ID" value="OXR43008"/>
        <property type="gene ID" value="B7C42_04894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="25384" checksum="C7CCB6E2D1F51743" modified="2017-10-25" version="1">MTGNHKSALISGASRGIGLGIANRLAEQGYSLTVTARDAGRLEEVAAQLRSAGAADVVAVAADMSDTEGVERVVAEHANRFGTLSALILNAGVGTAGPLADTSVRRFDKTLAVNLRAPLQLIQGALPMLRAAAAAAPERGAKVIALSSITGVYAEAGLAVYGAAKAALISLIATLNAEESGNGISATTLAPGYVDTDMSAWIHDRIPPEQMLTVGDIVEMVDALLRLSSRAVVPNIVLSRAGTDAYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2L9</accession>
    <name>A0A231H2L9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme oxygenase</fullName>
            <ecNumber evidence="3">1.14.14.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hmuO</name>
        <name evidence="3" type="ORF">B7C42_04989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43103">
        <property type="protein sequence ID" value="OXR43103"/>
        <property type="gene ID" value="B7C42_04989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="25203" checksum="34ED6B6D44427CB2" modified="2017-10-25" version="1">MPDATSTEQPVPFSAQIRSATAEQHERAENSTFMSDMLGGALDVSAFYRYTGQLWHIYQALEAHWDVLAADPVAGPFIRPELARLAHLEDDLAHLGGPEWRDDITALPATAEYAARITECALHWPAGYVAHHYTRYLGDLSGGQVIRGTAAKLWQLPKRGDGVRFYVFDQIANPAAFKRGYRTLLDELAVDDLEKQRVLGECRRAFDLNSAVFADLASEFPVRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Q9</accession>
    <name>A0A231H2Q9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43126">
        <property type="protein sequence ID" value="OXR43126"/>
        <property type="gene ID" value="B7C42_05012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8687" checksum="0044519B503FB39E" modified="2017-10-25" version="1">MPSANSVPTLSRLDFDRLEHRGAAGTAAILDEMDSAVADRWRGEHAGWRGRHWAYLDDAHGGLRLHPINVTRASRQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2U2</accession>
    <name>A0A231H2U2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43118">
        <property type="protein sequence ID" value="OXR43118"/>
        <property type="gene ID" value="B7C42_05004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="44098" checksum="9A1FD58DD07DC65D" modified="2017-10-25" version="1">MTDPILGPPCAVCDGTTSDTELCITNAAVCESCWQQLPRCDYCRTPSLRLTHTAEESQLCAHCVTGWAGCASCRRLTGPHLRTDTDAPVCARCAGALYTACFSCGRFSADSRYISGGHRACPRCASRFRACAECGTLVQPGQRCEACTHRGKVWNYTYRPDPRFHGTGPLYLGLELEIIVPERRFDTCAVLATDNLGDLGYLKRDSSIRPCGFELVSHPMSYRYAIDAFPWPLLDQLHRLGCEADASVGLHVHASRAGFDNPAHVYRWLKLLYRNETAVTRLARRRTHYAQFDSAARARARHTAKGPQHALGLERYQAINPLPRNTLEVRVFASSLDVQQVQAALAFTAASIDYTRGLRVADIRAGAWDWARFATWVTTRPDYQPLAAEMENLQCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H306</accession>
    <name>A0A231H306_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909001.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43188">
        <property type="protein sequence ID" value="OXR43188"/>
        <property type="gene ID" value="B7C42_04610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="26282" checksum="0B10E88079E3ACBB" modified="2017-10-25" version="1">MNLADSVVLVTGGAGGLGEAVVREVAAAGAAVVIADLADEKAEKLAADLGSKVKYVRTDVTDEDSVRNAVAEAGKLGTFRYAVVAHGGFGVAEKVVGKDGNPASLTGFTKTIDLYLTGTYNVLRIAAAAIAGTEPDEDGQRGAIVATASIAAFEGQIGQIAYSAAKAGVVGMTIVAARDLGSLGIRVVTIAPGTMRTPIMESVGDEALAKFAANIPNPRRLGKPEEYGALARHILENAYLNGETIRLDGAQRFTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H371</accession>
    <name>A0A231H371_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoglycoside phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43299">
        <property type="protein sequence ID" value="OXR43299"/>
        <property type="gene ID" value="B7C42_04721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="39"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="37468" checksum="86CFFD86837BE09B" modified="2017-10-25" version="1">MRQSDAATRLDEATLADELAIRATDAAARAITGATVSAVRPLTGGTSSLTFVAELTAPGSTGSVVLKVAPPGLMPVRNRDVLRQGRVMAALAQAPGVRVPSVLFDDDGLPPRTPPFVAMDLIAGECVEPLLEDVREAAAKPRIRARYLDAARMLGHLHRVRPEQVGLADEPAVTLDAEIDRWTRAFETVPEDLRGNYRACALALHESVPEQAEPVINHGDYRLGNTLCADDRVTAIIDWEIWSVGDPRVDLSWLTFFTDEARHPAAPSLEPCGTPTIAEVVREYEGALGRSVSDLAWFDALTRYKEAAATALLIKRARKADAMPAAFLRMEPALPGLVEEAMALLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3H6</accession>
    <name>A0A231H3H6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rubA_1</name>
        <name evidence="10" type="ORF">B7C42_04330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="7 8">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the rubredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502897.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43463">
        <property type="protein sequence ID" value="OXR43463"/>
        <property type="gene ID" value="B7C42_04330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="9">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="60" mass="6795" checksum="E22A0118AA4C6627" modified="2017-10-25" version="1">MTDYKLFRCLQCGFEYDEALGWPEDGIAPGTRWDDIPDDWSCPDCGAAKADFEMVEVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3N9</accession>
    <name>A0A231H3N9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ORF">B7C42_04401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43533">
        <property type="protein sequence ID" value="OXR43533"/>
        <property type="gene ID" value="B7C42_04401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="576" mass="62391" checksum="F237E4B8BB3A9D33" modified="2017-10-25" version="1">MSDRWSRAGERSRRRADEQQRRYRRGGAHRSVTDEWDDYEDDDTAVIPRYVDEDESAAHYADPAAGYDARYDHELAGAGYPDPDYADPDYADDYAEPGYERTGRSGHRYRRDEYDSETDIEPIADEEPEPAPAARRGTRASAASLREAQRGSRRGATAPSAAARKARGGVGRPARSGSSGGRGRRTRVASRKAAERQRRRRNLVVLGCVFVVLFVVAGGYAGYKFIRSMGGPEDFDGSPGPLAVVQVHTGDTAEQIAQTMVEKGVVRSSGAFYQAAMRNSGITSVQPGYYAVPTHSKGTDAVAALLKKTSRVGNVVVSEGRRLHDSTDVNTGARNEGIYRKIADASCVGTGADKKCVTYEQLDAAGATADATALGVPGWAVDAVRKVPDRTRQLEGMIAAGAWDFDPSGTPEQILAQLVSESAAGYETTGLLQSGATNKLNPYQTLIAASLVEREALPQDMTKVARVIVNRLAVDQPLQLDSTVNYTLDRTEVATTDADRARKTPWNTYAMPGLPATPISSPSLDALRAVESPAPGPWLYFVTVDKQGTTMFTESYSEHLRNIQRAQQSGILDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3V5</accession>
    <name>A0A231H3V5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43442">
        <property type="protein sequence ID" value="OXR43442"/>
        <property type="gene ID" value="B7C42_04309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5572" checksum="61E358E7A2730A42" modified="2017-10-25" version="1">MCVPITCTTCGKTTWSGCGAHIDEVRATVPADRWCGGHTDPAPAKRWWQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H469</accession>
    <name>A0A231H469_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribE</name>
        <name evidence="4" type="ORF">B7C42_04450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43582">
        <property type="protein sequence ID" value="OXR43582"/>
        <property type="gene ID" value="B7C42_04450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="206" mass="21649" checksum="772A5A29081F9427" modified="2017-10-25" version="1">MFTGIVEELGEIVAAERSADAARLTIRGATVTSDARHGDSIAVNGVCLTVVDVVEGDSFTTDVMGETLNRSGIGKLDIGSKVNLERAAAVNSRLGGHIVQGHVDGTGVILSRTPSDNWEVVRISLPDSLARYVVEKGSITVDGISLTVSGLGVDEAGEPGHRDWFEVSLIPTTRELTTLGAAPAGTTVNLEVDVIAKYVERLQQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4F7</accession>
    <name>A0A231H4F7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pitA_3</name>
        <name evidence="8" type="ORF">B7C42_04068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781148.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43833">
        <property type="protein sequence ID" value="OXR43833"/>
        <property type="gene ID" value="B7C42_04068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="442" mass="45105" checksum="4CE87DE54BCAECE4" modified="2017-10-25" version="1">MTAELFVLLIVVVTALVFDFTNGFHDTANAMATSIATGALRPRAAVLLSGGLNLIGAFLSVEVAATVAEGIVRLDEVGGADLLAIVFAGLVGGILWNLLTWLFGLPSSSSHALFGGLIGATIAALGWSGVIWSAGQKGVLTKIIVPAVLAPVVAALVASVGTWLVYRITRSSDQRVVNRSFRWGQIGSASLVSLAHGTNDAQKTMGIIFLALIAYGSKQPSDPLPLWVIVACAVAIAAGTSLGGWRIIRTLGKGLVDITPPQGLAAESTSAAIILTSAHFGLPLSTTQTVTGAILGTGMGRPGAEVRWPVLGRMVVAWVFTLPLAGLAGAICWALAHLIGGLPGVLVVFAILVAMAGLIYLRSRRTPVHAANVNEQWTSLPGADGTGPAAETRPGNLESGPAAESGPAGSAPADAAASAPPEPGKPARTDDSRASHRAARNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4R4</accession>
    <name>A0A231H4R4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">galE_2</name>
        <name evidence="3" type="ORF">B7C42_04017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43782">
        <property type="protein sequence ID" value="OXR43782"/>
        <property type="gene ID" value="B7C42_04017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="368" mass="39930" checksum="4E36DC11DC556856" modified="2017-10-25" version="1">MGFGVGSDMRDGRTAGRDDQPPQVVLVTGASRFFGGNVITRLAADPAIERVIAVDARMPSRDLLRRMGRAEFVRADIRNPLIRKVIDGNKVDTVVHPAVLSRPPAGGGRAAMKDYNVFGAMQLMAVCQKAPSVRRVVVRSSSAVYGCGPKDPAKFTEEMSARTPPKGWFARDMIEVEGFVRGMARRRPDIAAAILRFAPIVGPRLAGRGVQYFRSPITPTIFGRDPRMQLLHEEDAIAALAHAAHSAPGGTFNVAGDGALALSQAIRRAGRVELPVPMSVFHTVGRSFMGPVMREFTTEQIDYFHFGCGLDTTRMRTELGFAPRWTTVQAFDDFIGGAALRPVIDPRWIDAAENRLLGLVGAGTGAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4S8</accession>
    <name>A0A231H4S8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781106.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43871">
        <property type="protein sequence ID" value="OXR43871"/>
        <property type="gene ID" value="B7C42_04110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="136"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="36235" checksum="995C5099F6547576" modified="2017-10-25" version="1">MEDRVLLGKRSPAFMGGLGLFMVLLIALSAFFLDKLPIIGASTSYTAEFSEAAGLKKGNEVRVAGVKVGDVSDVRLDGDRVLVDFRTKDAWIGDATTASIQIKTLLGQKYLALDPKGSHPADPDKRIPLSRTVSPYDVVEAFSDAASSIEKTDTAQLATSFRVLSDAFSGTPPEIRGSIDGVARLSETLAKRDEELKHLFNATNKTTKVLADRNEQFERLLANGGELLAELNVRQQAISQLLNGAKTVAAELSALVHDNEQQIGPALTNLKKSIDMLNDNQQNISKTLKLAAPFYGLYANVLGNGRWFDAVIVNLIPPALPEIPGNRPPIRTLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4T6</accession>
    <name>A0A231H4T6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplL</name>
        <name evidence="7" type="ORF">B7C42_04104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505922.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43865">
        <property type="protein sequence ID" value="OXR43865"/>
        <property type="gene ID" value="B7C42_04104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13131" checksum="468C57F8E33BFC77" modified="2017-10-25" version="1">MANVDELLETIGNMTLLELSDFVKKFEEKFEVTAAAPVAVAAVGGAAAPAEAAEEQDEFDVILEGAGDKKIQVIKVVREIVSGLGLKEAKDLVEGAPKPILEKVAKDAADAAKAKLEEAGAKVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H531</accession>
    <name>A0A231H531_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44009">
        <property type="protein sequence ID" value="OXR44009"/>
        <property type="gene ID" value="B7C42_03565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="11425" checksum="13ADA4F7CB74EC0C" modified="2017-10-25" version="1">MVEARLNLAALRFDSNDFVGAAELFRTLIDDLTAERGPYDEQVMHCQRQLAACDVQTGDIDAALTRLRRLHGQMSVRYGEQDRRVVDLVDQIRYIERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5A7</accession>
    <name>A0A231H5A7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03573</name>
        <name evidence="2" type="ORF">B7C42_08171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000071">
        <property type="protein sequence ID" value="OXR39759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39759">
        <property type="protein sequence ID" value="OXR39759"/>
        <property type="gene ID" value="B7C42_08171"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44017">
        <property type="protein sequence ID" value="OXR44017"/>
        <property type="gene ID" value="B7C42_03573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="18191" checksum="C24AD164612BFB2C" modified="2017-10-25" version="1">MAKTTAFEDIFLAPDEPAWGDERAREEFYRGSTMALCATIYGCYAIAIVAAAVDAKWVSLLIFVLPSLTSLLLLRYCARRGIDMRTLLKNFPLRRKRIAYATTYPLIAAWLIVFLWRTLPSDSLPQSLLGAVVGGAIGAGVAVVIGTLFRRRSAAENLPEDDSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5G0</accession>
    <name>A0A231H5G0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44203">
        <property type="protein sequence ID" value="OXR44203"/>
        <property type="gene ID" value="B7C42_03763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="32033" checksum="68AEB494E70F9679" modified="2017-10-25" version="1">MSLDRRAELGEFLRSRRARLRPEEVGLAEHGTRRRVPGLRREELALLAGVSVDHYVRLEQGRTLHFSESVLDAVARALRLNPLERDHLYRLARPWSGTEPVAAQQVRPGLRRLLDSSEAPAYIVGRGTNVLAWNRAAAALLTDFGALPPEQRNLARLVFFDEGMRELYEDWPAKAADVVAYLRLDAARNPGDHGIAALIDELRRRDPDFERVWSRHALKDKTHGRYVYRHPVVGRLDLGFETLRLPDDPDQALIVHTVEPDSPSATGLRLLTDWTADTETAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Z1</accession>
    <name>A0A231H5Z1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH-type transcriptional repressor NsrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nsrR</name>
        <name evidence="1" type="ORF">B7C42_03875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777677.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44314">
        <property type="protein sequence ID" value="OXR44314"/>
        <property type="gene ID" value="B7C42_03875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="160" mass="17055" checksum="C05F974685D4AAB3" modified="2017-10-25" version="1">MQLSRFTDLGLRAMMRLAVSSGAEERVTAKLIARQVNASEHYVAKAVTKLSELGLVASQRGRAGGIFLTDAGRTATVGQIVRGLEGAAEVVDCVGDHPCPMAGACRLRRILAEAQESFYRELDRYTLGDLVDRRTQQLLHLSASPALPFGGFAAGVPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H610</accession>
    <name>A0A231H610_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44202">
        <property type="protein sequence ID" value="OXR44202"/>
        <property type="gene ID" value="B7C42_03762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="22437" checksum="FE60F5E7EDD0FE17" modified="2017-10-25" version="1">MSTRQLLNDERAELITLLRDLSDDEWEAPSLCAGWRVRDVVGHLLYDEMSLLGYARFALGYRLNTDRVNNGLVDRARDLTPAQLIERFDNSGQRITGVWPSLGLADILVHQQDIRRPLGRPRTIPADRLVAVLRHPDPFARPRTYTRGLRFVATDVEWSAGTGPEVRGPGEALALAAVGRPAALEDLTGEGVETLRRRHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D1</accession>
    <name>A0A231H6D1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_03220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44431">
        <property type="protein sequence ID" value="OXR44431"/>
        <property type="gene ID" value="B7C42_03220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="28919" checksum="3825EC004EF715E4" modified="2017-10-25" version="1">MIDVLACARAEFARLRKWPAFWIVLGTWIALNLVFAYLFNYLAYTSGSSSRMSNGQPREVLLQLMLPAAVPEVFTQGMAMFGGALMLVLGALVVGSGYGWGSWKTAFTQGPSRGAVVGGTVLSLASVVVGLVGAAFVVDTGVAAVIGVAEHQALTLPTAAHTLLGLATGVVILGMWTLAGALIAAIARGPALAVGLGLVWVLVVENLLRGVASIFSPIRVLTDHLPGTAAGSAAGAMRSVGGAATPGVLDILSRPASFLVLAAYIAVFACATVVLMVRRDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6W5</accession>
    <name>A0A231H6W5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775761.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44466">
        <property type="protein sequence ID" value="OXR44466"/>
        <property type="gene ID" value="B7C42_03255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="196"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="424" mass="46367" checksum="C85F29D1A2E9DA07" modified="2017-10-25" version="1">MRHRDTTSASEVDLRWRPAPLVYMLAVAAAVALVPAIMLDRWQLAVFAAPMLGVLATAPIQLSRTRVQVDGGGIMRCFESEEVELPVAAFVEHGHALLRCRPEEASGLELRVEESSDSGPAPAGLRLALSTQRWGRYPVTVRLTALSPAGLAQASASVAAGEVYVYPIADPQRMRLPRTELPERIGTHLTRRHGPGVEYADIRAYAPGDQLRIVNWPVSARRGRLYVTERLTNRAADVVVLVDTSLQAPGPASDSMELTVRGAAQVAQTALQAGDRTAVVCLGRAPRWLRPDIGRRQFYRIVDTVLGVGDEHIPNVGTLAPHTAVPIGAIVVAFSTLLDTEFALALIDLRKRGHAVVVVDVLRGTPFKDGLDPTLARMWQLERTAMYRDMGTVGVDIVAWPDGARLDQAMRLLPDHRRMVRVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6W7</accession>
    <name>A0A231H6W7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44487">
        <property type="protein sequence ID" value="OXR44487"/>
        <property type="gene ID" value="B7C42_03276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8386" checksum="232FDE48E5B5A34B" modified="2017-10-25" version="1">MDAGERRARLFVFPGGVLETVDYGDGDSGGVYLEFMSRVLPQRVPGGVDVPPPLHPVESADAETCGRVLRSLREWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Y7</accession>
    <name>A0A231H6Y7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041914.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44684">
        <property type="protein sequence ID" value="OXR44684"/>
        <property type="gene ID" value="B7C42_03478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032407">
        <property type="entry name" value="MHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038378">
        <property type="entry name" value="MHB_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04529">
        <property type="entry name" value="MTB_hemophore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011277258" evidence="2">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13423" checksum="864E7C039ECBD23B" modified="2017-10-25" version="1">MRIRGFAATTLTAAGLAAGAALLVPATASAGPTELVAPLLNSTCSFAQVDAALHDKAPQLASILDNNPDQKAQLKAKFDQPVEQRRAEFQQYLAQHPDEAQRAQQDPRAAGLSRTIQEVADSCHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7N6</accession>
    <name>A0A231H7N6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoin dehydrogenase operon transcriptional activator AcoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acoR_1</name>
        <name evidence="4" type="ORF">B7C42_02812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44858">
        <property type="protein sequence ID" value="OXR44858"/>
        <property type="gene ID" value="B7C42_02812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="238"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="44115" checksum="B4FA458905C30D29" modified="2017-10-25" version="1">MNDSSTLVRRRAALESEWARWVRGGADTLSPSKALCDSTLRAEVSRSWRRSLGSVDPARDSAPGSDTDIGARWLDSPLYRPVTELAEQLRGIAEDAGFVAAVTDEDGTILWSCGGPVMRRRAERVNFAPGGRWDETHMGTNALSLALRTGRPNQVFSAEHLVEALHGWVCYCAPIHGADGRRLGSLDLSSTWDRTHPLAMATVRSLVAAIENRLRVLAPPATGLRLNCLGAARATRDGAPIRLRPRQIEILTLLALEPAGFTPERLHYAIYGDRPVVSSTLKADVSHLRRATDAAIANRVYRLTAPIRCDAADLLTALDAGDTDAALRLYRGPLLPDSETPAVVEWRQHLEVAVRAAVLAGGDPGHALALGERMPADVEIHERALELLPAGDGRRAVAAARLHTALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7X4</accession>
    <name>A0A231H7X4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45113">
        <property type="protein sequence ID" value="OXR45113"/>
        <property type="gene ID" value="B7C42_03070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="24519" checksum="A28088BF3D73C4EC" modified="2017-10-25" version="1">MSDKESGGAEEREPTVDTVDEPETAAAVASGASDTAGSDAAGTSDTTETTTADKVSPLSRLRPAAGGRGVRIGLRAVVAVVLGAAIGTSIYFYLQNKDHEEVLGAQAQARQAACAYGPVVSTYDSKHLDQYVRDVLAGASGEWKKQFESNSKDLSDVLAKGEVVAKSTDVQCAIRSGDKNSAEAIVVIGQTITSLGTQGKPEPGQLSTVMRLQKEGDRWLVDKISTPLTPLPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H893</accession>
    <name>A0A231H893_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779967.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45020">
        <property type="protein sequence ID" value="OXR45020"/>
        <property type="gene ID" value="B7C42_02977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="12347" checksum="72B18FE8BBB718AF" modified="2017-10-25" version="1">MSKHRRDPDLVRAYVRTGGRTRASRSVDLVTLVVAAQDPTPGASPDARRVLNVCSRHAALSLAEVAAYLDLPPSVVKIVVSDLLDSGHLVNPTPADHVPEVALLEEVLNGLRALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Q4</accession>
    <name>A0A231H8Q4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aliphatic amidase expression-regulating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">amiC_1</name>
        <name evidence="2" type="ORF">B7C42_03063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45106">
        <property type="protein sequence ID" value="OXR45106"/>
        <property type="gene ID" value="B7C42_03063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="12"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="38755" checksum="22C1322AEF7416A1" modified="2017-10-25" version="1">MRVSNSRGGRDTVDIALVVPGSGPAGLFGPSCEACAALAVEDINRAGGILDRPVRLHTVDAGAPLPLLAERIDRMIGTGAVDGVVGWHLSNARRVLTPRTAGRVPYVYTTFYEGGENSDGVYMVGETPDHQLFPALRWLRAEQGIRRWCIVGNDYVWPRETARVTREAAAFGDIDIVGETFVPLGGRAFGPALDLIRRSSAQGVLLLMVGADCAAFNRAFARAGLDEDRLRLSMMIGEDVLYAGGPDSTRGLFTASGYFESVVSPEAMEFGSRYTARYGTFAPALNNIGESCYEGLLLFASLAEAARSLDVRAIERHAARVRYGGPRGEVKVRGAHTTQPVYLADADGVDFEVVSELRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Q5</accession>
    <name>A0A231H8Q5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="3">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pntA_1</name>
        <name evidence="12" type="ORF">B7C42_02364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776763.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45239">
        <property type="protein sequence ID" value="OXR45239"/>
        <property type="gene ID" value="B7C42_02364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB_4TM" evidence="11">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR45239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="105" mass="10917" checksum="CC7FFA4EDF614B93" modified="2017-10-25" version="1">MYTELLANIAILVLSGFVGFAVISKVPNTLHTPLMSGTNAIHGIVVLGALVTLGKVEHPSVITQIILFVAVVFGTLNVVGGFVVTDRMLGMFKGKKPAAGEKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8U8</accession>
    <name>A0A231H8U8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776756.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45251">
        <property type="protein sequence ID" value="OXR45251"/>
        <property type="gene ID" value="B7C42_02376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011311103" evidence="1">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="10982" checksum="0B4954E063808AAC" modified="2017-10-25" version="1">MIKSLPAVVFAAVTTASLLLLPTATAEAKSPACDRAIAMVNAGVQMSGGTFDAETARALHDRLWTVGDLAAGEERAAITGYADALIDDSVTDLQPFTDELNRVCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8W0</accession>
    <name>A0A231H8W0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_03084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780086.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45127">
        <property type="protein sequence ID" value="OXR45127"/>
        <property type="gene ID" value="B7C42_03084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="20289" checksum="76FC83B02CF35FBF" modified="2017-10-25" version="1">MTSPWLWYVSRAAGVVTLVLLTLVALLGMFTAARVRPRLAVSAVAMGLHRTLALGTIVFLAAHIVTATVDTYVHLGWLSTVVPFTAGYERQWVALGTLALDILLAVVATSVLRHRLPTRIWRAVHLFAYAMAPLAVGHGLTMASAQDPALVAVTVACGVALAVGAVWRWAFPDADRHRRSDIASQEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9A3</accession>
    <name>A0A231H9A3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45382">
        <property type="protein sequence ID" value="OXR45382"/>
        <property type="gene ID" value="B7C42_02507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="102" mass="10922" checksum="1E490E3DBAEE3CEE" modified="2017-10-25" version="1">MNESQIDLAHTVALGSIGDEDQRAVQELFDSGDPILRADFDTEVQLTREALTLFASASAVQPPATLRTRLLAAIADDHAPAARHIRPPAHRNGEEAGPTSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9D9</accession>
    <name>A0A231H9D9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45346">
        <property type="protein sequence ID" value="OXR45346"/>
        <property type="gene ID" value="B7C42_02471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="644" mass="67509" checksum="CC01BCA838E0AAA8" modified="2017-10-25" version="1">MANYLDLDPDQLRVYAEQLERYAAAMRKWGEIPESWLTEFPDGYGTIADPMHGALKDYYRKRHEKAEAQAASAERTAHDLRAAAGRMENTELSGGHQISNAGPHGGPSPVTHGPSAPDGDTPKTPGISNDSPQRAPDGPARPVVGHNDGVTDPGAATPDQPGYGGAPAFAGANPVAPIDVSHSMPSPEHRVDGSAPPPPHGVPGDDSTPEDAGVFTAEYGTGTQPDAPAAATAPPTGPTGPLPAGPAPEPPRPLRPGPLAVSSQPVRGHRQGLPQLIVGDGGEDDLTLARTLLSAVLFAVGDSAPGVEWATGVVRNRRGAVVLLTSTEGRGWLPAGLFVPSEVLIPWRWDSILDAEGRRAITAFENNADPARILTEFAHHAARAKRGHLRALASTSGVGDYVRATLGSEVAIADLVVATETSVDLSSPGAGLFDRLDAGGSATSRQRAAEVADSDIRAVCVQLAREADALARQAMPDATPEARAQRARRQEVLHSLGARDRVSASSRPHLPPADQDLVAPASAVFAPSGSSRAAATSAIISSSFSPPPDVDTERSRMFERRADELISLLLTEKDDHRMLRDVLYVHDQIAEHPQLQSILGKVPTATANATSVDTGSAGPNLSPAAEYRSFPVSPGRYGEERSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9F1</accession>
    <name>A0A231H9F1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45327">
        <property type="protein sequence ID" value="OXR45327"/>
        <property type="gene ID" value="B7C42_02452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="3">
        <location>
            <begin position="15"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="34593" checksum="98AA3A838E836FED" modified="2017-10-25" version="1">MPGPGYFSDDSMIRRVMRKRAVGLTYGLRALVIGAVHPLLFVGTAENTAHRATPYTRLALTGRLFEAVFLGDKDEADRALAFTRKRHVPVDGVLPEDAGPHHPAGSHYSALDPHLMFMTMAFTADSAEVMHDLLVRKLTPGEREDLYQDYVRWGELFGMPRSAAPADYPAFRRVFDAYLASDELYLTDEARLVGSYLAGKQVPHPLPRPFQQAGSGAHLLVQGSLPPRIRRMYDIRWGRREELAYRGLAQAVRTAHVRPPFAPPVLRDTLSGPSAPVYRLITRREKDLVASGRSSMPGVDPRNYAERHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9M4</accession>
    <name>A0A231H9M4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid-associated protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybaB_3</name>
        <name evidence="3" type="ORF">B7C42_02522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45397">
        <property type="protein sequence ID" value="OXR45397"/>
        <property type="gene ID" value="B7C42_02522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="19093" checksum="48A8022FE6719B63" modified="2017-10-25" version="1">MADAEREAARARNEALRLEVDSLLATFEQQKRELADVQERLAATTAEAWSADNLVRVVANVAGVVVEVHLEPEAFKRSTPEKLGRSMAEAAQAAARRAGELSQQALAPIQDVAGDVPDLSDILPGAPSIKDLMNSLLPDPAASVPAQRDSPEPRAFDDEDEDDYYRNRGYLRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9P8</accession>
    <name>A0A231H9P8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45578">
        <property type="protein sequence ID" value="OXR45578"/>
        <property type="gene ID" value="B7C42_01870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="19850" checksum="4B3114CE796871E5" modified="2017-10-25" version="1">MPKNFACGAGRAGDHVLVQVDTSRAQTGDEGEDMGGFEDSAQCIGRRDPRHSGMLGDVAEAEPGRLRGVLIIESLRPVAELTDLAIAVSTISRIRPEIRGAGQPDTWTLIHFEADVAAAERLAAIFADTLEAGPWYIDFHTATTTYVVFSGRVFSYSRNEPDGRDNAIAHARAVGIPEAQLDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9R0</accession>
    <name>A0A231H9R0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45595">
        <property type="protein sequence ID" value="OXR45595"/>
        <property type="gene ID" value="B7C42_01887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="25089" checksum="CA9930E9290B1C1B" modified="2017-10-25" version="1">MTVATSPDADTTRDRIVTAAVSEFAQYGVAGARIDRIARAAKTSKERLYAYFRSKQQLYRFVAERELAAMTEATHMDALDLPGYAGRVHDYFMAHPDHLRMLQWGRLDTPDVATAADPFQESVRQTVRGSVEQIQNAQLAGHLDPAWDPIDIMVIVTQIALAWAWQPDLVELAEGQVRDPSDAARRAAVVAAVAGLFPTADPEAAPVSPGTDGTSPSLVREDRGVRSCGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Z9</accession>
    <name>A0A231H9Z9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45671">
        <property type="protein sequence ID" value="OXR45671"/>
        <property type="gene ID" value="B7C42_01963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="23938" checksum="A898BD7621896A8F" modified="2017-10-25" version="1">MTGESFQRARTAAQRAERVHAVLAATRALLATVDVTSLSLGAISREANLASSNVLRYFGSREALLLDLLDVEYRAWTPHLETTVRKHRGPLDVDQVAAIVAGDLAERPILTRLIAASAELLQYPMPEAARERCREQGRHNRAELSRILTAALGIELRARDQAYLVAGFHAVVTAVSAWSNQPTFPVGTTSAIRELLAIQLQGLICRRAGGHHAHDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAA5</accession>
    <name>A0A231HAA5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">galE_1</name>
        <name evidence="9" type="ORF">B7C42_01968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782482.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45676">
        <property type="protein sequence ID" value="OXR45676"/>
        <property type="gene ID" value="B7C42_01968"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="34308" checksum="E1157CA291DD1919" modified="2017-10-25" version="1">MTWLVTGGGGYIGSHVVRALLAAGRPVVVLDDFSTGRRAVIPDDVATVAASITDFAAVTAVLRDYEITGVAHLAGRKSAVDSVTHPLEYYEQNTGGTRTLLAAMHATGVEHLVFSSSAAVYGSQIGDGSVGEQAPPRPINPYGRSKLACEWIVADAAAEFDRLNSTVLRYFNVAGAGGPGLGDRNATGLVPNVLQAISSGRPPVVFGADYPTPDGSCVRDYVHVLDVANAHVSAAERLECGQPGTSVYNVGTGRGYSVFEILDAARAVTGERFRHLVGDRRPGDPPRVIADIARIGDELGWRARLGLAEMLGSEWEARCGVPGGLTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC4</accession>
    <name>A0A231HAC4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative thiamine pyrophosphate-containing protein YdaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ydaP</name>
        <name evidence="7" type="ORF">B7C42_02196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45904">
        <property type="protein sequence ID" value="OXR45904"/>
        <property type="gene ID" value="B7C42_02196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="199"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="389"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="601" mass="65382" checksum="99213D7826B18E37" modified="2017-10-25" version="1">MAQQVADYVVARLNEWGVKEVFAYPGDGINGLVAAFGRTDDRPTFVQARHEEMAAFSATGYAKFSGHVGVCMATSGPGAIHLLNGLYDAKLDHVPVVAIIGQTARSAMGGSYQQEIDLQSLYKDVASEYLVEVNVAEQLPNALDRAFRTAWTRRAPTAVIIPADLQEETYEPPQHEFKQVPSSPPAEMHSVVVPARAEIERAAEVIGAGSKVAILVGQGARSAAREVTELAEITGAGVAKALLGKDVLPDDLPFVTGPIGLLGTRPSYELMRDCDTLVIVGSNFPYSQFLPPLDQARAVQIDIDGTMIGMRYPTEVNLVGDAKATLAEIIPLLKPVSDRSWRETIESNVSRWWETVERQAMLQAEPVNPMRVVWELSQQIPDNAIVTADSGSSTNWYARCLRFHGSMRGSLSGTLATMGPGVPYAIGAKFAHPDRPVIALVGDGAMQMNGLAELITIARYTEQWSDKRLVVCVFHNNDLNQVTWELRSMGGSPKFEDSQSLPDISYADAARCFGLAAIEVDDPEQLAGAWERALTADRPTLLDVRCDPEVPPIPPHATWDQMKATAEAVLRGDPNAWHLVTQGMKTKAQEFLPGRRSGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAM3</accession>
    <name>A0A231HAM3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45777">
        <property type="protein sequence ID" value="OXR45777"/>
        <property type="gene ID" value="B7C42_02069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="13918" checksum="A4832FB33CFF552A" modified="2017-10-25" version="1">MRFDPMRAAARVLMGSTYAVLGADALREPGPRPEAAAPTLAAVRSVVPLPADDKLLVQVNAGVQVAGGVLLALGRLPRLSALALVASMVPTTIAGHAFWAIDDPGARKPQQVQFHKNMAMIGGLLFVASDKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ0</accession>
    <name>A0A231HAQ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063820473.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45816">
        <property type="protein sequence ID" value="OXR45816"/>
        <property type="gene ID" value="B7C42_02108"/>
    </dbReference>
    <dbReference type="GeneID" id="66720179"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="5474" checksum="3E4161242829F956" modified="2017-10-25" version="1">MKTRLGCPCGEQIVGTDEDDLVEKTQKHLAENHPGHDYSRDEILFLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAY7</accession>
    <name>A0A231HAY7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pknF_1</name>
        <name evidence="5" type="ORF">B7C42_01058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46094">
        <property type="protein sequence ID" value="OXR46094"/>
        <property type="gene ID" value="B7C42_01058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="789" mass="82676" checksum="D1A72C89A117852D" modified="2017-10-25" version="1">MLHSGEMFAGYRIERVLGAGGMGEVYVARHPRLPRSDAVMVLPAQYAADPEYRARFEREADLVASLSHPAIVKVYDRGEYEGRLWIAMELVDGVDLAQRLSVTGPFAIDEVIRIAETVAGALDRAHTQGLVHRDVKPANILLSRDGDVLLTDFGIARQAAGSSDLTGTGVMIGTLNYASPEQLSAQPLDGRSDQYSLACTIFHVLTGDAPFADTNPVVVVTRHATATPPSVRTARPHVHPDVDAVLARAMAKRPADRFASSSEFATALGAALRATPAEPPDDPQAAIATVLAGQPVPALDGSAAASPTVVSAAGAALPPSQRGGDGGPRSMWAAVGTVAAVVAVVAAVTAFVLHASGPDEVGPTDAARALARISVTPQSPDLSAEPTGKRWSAEGWALPIGGTDKVVFYNGTRKLDILDVESGALLHSVGVGYISYAECVFTASGRYAGCRTESGDSAAGTRDVNSDSYATLLIDTQTGVISGRLPAATEIVSAGETFATFEPERKGAATGSVIAADVTGTVLWRADDIQAGLVHGSGVLSLRKNPVSGDPFSKADFELRTIETGKVVYHMAPDHVQPHTVWAPDWLAYSGGFAVGADFFALDGTKRASAGPGWRVVASQPYATQGDDPAPNGNAKRYAEPDTAPALPVMTNRDVFAAFDPATGTMLWSRKLPKEASYGHGVSVAGIGSKILIRWDTTTTSGSDYLENRYQLAYAWFDAYTAAGGVLPDNQVPWATDGTRVVTVARGGQGGITVVAAGKNQQPVWSLDFGSSPIRTFAGRVYLAHSRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB10</accession>
    <name>A0A231HB10_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator YodB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yodB</name>
        <name evidence="2" type="ORF">B7C42_02229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45936">
        <property type="protein sequence ID" value="OXR45936"/>
        <property type="gene ID" value="B7C42_02229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="21614" checksum="8F38F6DE5390B510" modified="2017-10-25" version="1">MPRRTYDHYCPVSRALEVVGDRWNLLLVRELCSGPRRYSDLFADLPGISTDILAARLKDLERDGILTHRKMGSRSAAAVYELTPTGAALRPVLQALSEWGAPLLGDRRATDAVRAHWFALPLGRAIADVVPAGTVTVYIGDTALHYVIGAAGISHHEGPAPAADHEFRLAMTEATEIATGARHLADVVGEPGRGGRSYKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBC0</accession>
    <name>A0A231HBC0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4189 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043329.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46017">
        <property type="protein sequence ID" value="OXR46017"/>
        <property type="gene ID" value="B7C42_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025240">
        <property type="entry name" value="DUF4189"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13827">
        <property type="entry name" value="DUF4189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011250003" description="DUF4189 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4189" evidence="2">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="14305" checksum="26D6700F9E8CAD59" modified="2017-10-25" version="1">MFSTGKLALSFVAASAAVFVVAGTGSAAAERGPDGHYYGAMAISDANDEGWTIGIALNAPDQATADAGALDQCSSHGEQGCATIVRFVDGCGAIARRDDIHTGGTGATLQDAERNAIAALGPGHPPTLSSDGSGPAVISVSRCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBC6</accession>
    <name>A0A231HBC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46180">
        <property type="protein sequence ID" value="OXR46180"/>
        <property type="gene ID" value="B7C42_01145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="40" mass="4215" checksum="5D82B587BD5C5FF3" modified="2017-10-25" version="1">MTLCGVQAAGTTTVASTLLGTLREDARSRQEFFSRTGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBJ9</accession>
    <name>A0A231HBJ9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_E_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051025284.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46323">
        <property type="protein sequence ID" value="OXR46323"/>
        <property type="gene ID" value="B7C42_01289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18369" checksum="85EC156A931AF6F7" modified="2017-10-25" version="1">MDFEVVERHETLVAGTVLRSPALAVEGPRRQKVEEAWKRTLARRLPGPPATAYVDHAPEIGSYLTHIVGYQCESLDDLQPGDVLARIPAAKFARFLRTGDNLGDTIVSIWRAVWDLEAAGALVRAYTGDFEHYPEARTVEVFVALQSDPLTDALNNGVAQADSAENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBL9</accession>
    <name>A0A231HBL9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46334">
        <property type="protein sequence ID" value="OXR46334"/>
        <property type="gene ID" value="B7C42_01300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="191" mass="20814" checksum="E89A62BA3A9C6701" modified="2017-10-25" version="1">MRLTCQGGYYDEVFTFVSGNVALDFAGTVQERDASFVDLLTTPAALGEWLIAAGLLDSAARCDAADLARAVELREAVYRLALATTTGEPWRDADRMLVNRIADGPKPSIALRADAGVTRRGDCDHALARIATEAIELLGGPDRDRIKQCGRDTCTRLYLDTSRAGSRRWCDMTLCGNRAKSASFRARRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC56</accession>
    <name>A0A231HC56_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase GlpE</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glpE_3</name>
        <name evidence="2" type="ORF">B7C42_01493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46523">
        <property type="protein sequence ID" value="OXR46523"/>
        <property type="gene ID" value="B7C42_01493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13405" checksum="1DC112E8C647FF49" modified="2017-10-25" version="1">MTSSEIPSVPVQDLPAEFDAAPSAGAGSGDGAPSAILLDVREDDEWQLGHAPAALHIPMIDVPARLDELDYDADIYVVCRQGGRSIEVAKYLAYVGFDVYQVVGGMVAWQQAGRPLSGAGDAEAKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCB2</accession>
    <name>A0A231HCB2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46459">
        <property type="protein sequence ID" value="OXR46459"/>
        <property type="gene ID" value="B7C42_01428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="PTHR37539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="126"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="418" mass="46807" checksum="5C019A868C45F6FD" modified="2017-10-25" version="1">MTTQLRTLKCPSAFRYWEAKQRPAVQRLEAIVRKVTGAELFPTDDQARALTEDLFAGDPVAERFVAEVMHGPGGSAAGRALLDRALAEGIDAVPEAPDSMRELFAEFDTVPAWVRPELVEQGAGIWRRWGTMLFSFAGAETLEMYTESAVATPLSLAGGYAGNSALRRYLETCRFWMDVSQPNALLTPGSTGRATALKVRVMHVSVRARVAGHPEWDIDKWGLPISQTYQLLTLIAGSVTPGLGLWALGYQTTPSEIRALLHFQRYMGYLLGVRLQWHPETVIDSLRVLAMTIASRSYDAGAHGAELIESYPAAFAPRPEHRGASRVRAAYNYRINSVYSAMYMAPGTRRKYRMPPAFPWLLIPLLRFPLITAMEFARRIPPVGRLHEKVMVRHRENWYRAQMQGREAEFDASGALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCN9</accession>
    <name>A0A231HCN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diacylglycerol acyltransferase/mycolyltransferase Ag85C</fullName>
            <ecNumber evidence="1">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbpC_1</name>
        <name evidence="1" type="ORF">B7C42_01546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46575">
        <property type="protein sequence ID" value="OXR46575"/>
        <property type="gene ID" value="B7C42_01546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="309" mass="33466" checksum="CF1F7CE8F55D1F4E" modified="2017-10-25" version="1">MALPIAAGIMAPAAIAAPVHAPVHQTPAGGYDELMVPSSMGPIKVQVQWARNGGNAALLLLDGLRARDDRNAWSFETNAQQMFGNDNVTLVMPVGGQSSWYADWQGPSNTNGQKFTYKWETFLTKELPDFLSNYGVERTNYAVAGLSMSGPAALRLAAFHRDQFKYAASFSGPLNWNAPGMREAIRVMMLDAGRFNVDSMAAPWSPQWLRSDPMVFAPQLRGLPMYISAASGLPGQYDHPNGLVGAFNTGNAMGIELISMVSTHSFKARLDSLGIPAAYDFPPTGTHAWLYWQDELAKARTGILAALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDC6</accession>
    <name>A0A231HDC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator MtrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mtrR_1</name>
        <name evidence="5" type="ORF">B7C42_01704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775324.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46727">
        <property type="protein sequence ID" value="OXR46727"/>
        <property type="gene ID" value="B7C42_01704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21451" checksum="FB115F6BA327871A" modified="2017-10-25" version="1">MSARTTSGSVAAGQSTKDAIREAAIRLFSNKGFEQTSLREVADAVGITKASLYYHYASKLDLLLAIIEPIFDDMKLVVDELDGVPHSPAGAREVLNRQLRTLLRHRTAGAMCVRDTVAILNAIGDRHPDMFDMHRRLCVWLAGPDPSHEARLRASAALEVLGTALWSNELVPDAGDEVIERVLTEAALGVLNGPGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDP3</accession>
    <name>A0A231HDP3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46868">
        <property type="protein sequence ID" value="OXR46868"/>
        <property type="gene ID" value="B7C42_01847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="550" mass="55324" checksum="11640CBF28912B1C" modified="2017-10-25" version="1">MPRHDIRQGYTVNSGFERNDDPTARREPTPDSNETPPTLAIRRVPGANFPVSQGSPWARPGSAPTAPGGAAEPARSGSPAEPAKPAAPDAGRSPGSPFDGNDAAAGQSSPPHPWSPQSSAAGDASRGPNAAPGSGNGQPNSGAPTAFQAPPIGPEGSAPYYPDAPASSPGTPPGFAPSPQGFGGPGGPHHPNPFGGQWNSGAPGAPPGPGGTDAPTTAFGARSGLPQWPGSAMPGANSASQQQFSAPHGNGRPEPDWHLGVGSHPAPQRASWGPPTAQHPHTALPQVPAEQQPRRRKALLLSGIGVLVVVAIGVTVAVVASRHSGSPAAAGSGKPSMVSALSSGNQPPPPPSRPQQTAPQQSAPKPQPGAAPPPMVPGYQVVQILDRGAAYDAPAEWKVDPIGTAAWGSGSNPLEIAGLAQDGKNYCPNYTRTNAFLTMSPQADPAAAAADIGARMAKFGWSNATVAAPAPAQPMVSLDGQLHGAFVETTGSAPPPAPGCATTFAVYTFAFPSENGNFVMTVAADTGVDKSVDKETAKRILSTIRPLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE39</accession>
    <name>A0A231HE39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator CdhR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdhR_2</name>
        <name evidence="3" type="ORF">B7C42_00332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47210">
        <property type="protein sequence ID" value="OXR47210"/>
        <property type="gene ID" value="B7C42_00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="227"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="36798" checksum="378E5E6237E6A58F" modified="2017-10-25" version="1">MTAEMVCESGQPGTVAVAVAPGQPVFEVAIPYQVFFEPPPGVDAEHWYRLRLCGPRGTRHATLRDPFVTLTDYDYDDLIAADTVVVPATPNVREDPPADLVAAVRAAYEAGARIAALCSGAFVLAAAGLLDGRRMTTHWKHVPALLERYPHLDVDASVLYIDDGRILTSAGTMAGMDLCIHLIRKDLGSHVANAAARGLVVPPHRAGGQAQYLRNPVPLDAADPGVAATLQWALTRLDTVLTVGDLARHSGLSERTLARRFHAELGTTPLRWLLTQRIIRARELLETTDFAVDVVAERCGLGSAANLRAHFGREVGVSPSEYRRSHRSNRHEVVVAAEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE92</accession>
    <name>A0A231HE92_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor RspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rspR_1</name>
        <name evidence="5" type="ORF">B7C42_00383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47261">
        <property type="protein sequence ID" value="OXR47261"/>
        <property type="gene ID" value="B7C42_00383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="24162" checksum="D2CC8D439B720DBE" modified="2017-10-25" version="1">MSKTYSAAERAYREIKERILTGALPGGELISEGEIANDLGTSRTPVREAFLRLETEGWMRLYPKRGALVVPIPSHEAEHVAHARYVVETAAVRALTAADRPPLLDTLRESLTRQRELVANLDASDGQALARFATEDTDFHRGYVVAAGNPLLTGFYDSLRERQRRMNSVALHRAPMNTARIVEQHARLTDLIAAGDTAAFDTALADHLSGVHQLELRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEB3</accession>
    <name>A0A231HEB3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="7">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fgs</name>
        <name evidence="7" type="ORF">B7C42_00284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47162">
        <property type="protein sequence ID" value="OXR47162"/>
        <property type="gene ID" value="B7C42_00284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="165"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="345"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="492" mass="51492" checksum="18110F3288ACFDEA" modified="2017-10-25" version="1">MSGGEGFDDEPLAGGPDRLRTGPSPVDLAEMALVEAELDQRWGETKIEPSLTRIATLMDLLGSPQQSYPAIHIAGTNGKTSVTRMVDALLTALHRRTGRFTSPHLQLATERIAVDNAPITPARYVEIYRELLPYVEMIDARSTDGTLGDGPGPRMSKFEVLVAMAYAAFAEAPVDVAVVETGMGGTWDATNVIDGQVAVITPIGLDHTDYLGPDLTSIAGEKAGIIKKSPQDLLIPRDTVAIIAEQEPEAMEVLLRRAVEADAAVARAGSEFRVLTRRVAIGGQVLEIQGLGGVYDEIFLPLHGEHQAHNAALALAAVEAFFGAGAQKQLDIDAVRAGFAAAASPGRMERMRSAPTIFIDAAHNPAGARALAATLTEEFDFRKLVGVVAVLSDKDAAGILAALEPVFDEIVVTTNGSPRALGVDELADLAVQRFGDERVVTANTLADAVETAIAIAEEAGDAGEPVSGAGIVVTGSVVTAGAARSLFGKDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEM1</accession>
    <name>A0A231HEM1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Decarbamoylnovobiocin carbamoyltransferase</fullName>
            <ecNumber evidence="4">2.1.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">novN_1</name>
        <name evidence="4" type="ORF">B7C42_00447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.12" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47324">
        <property type="protein sequence ID" value="OXR47324"/>
        <property type="gene ID" value="B7C42_00447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="116"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="371"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="540" mass="58297" checksum="CBA4385AB8653CB5" modified="2017-10-25" version="1">MRVLGINAIFHDSAAALVVDGKVVAAAEEERFSRRKHGKRPVPFSAWEQPGQAAAWCLAQAGLTAADLDAVGYSYDPAQVDESLGGLDPSWEPLRTRYAERAPYLLATELPGLDPDKVRFVRHHVAHAASCGLAAPFGDAAVLTLDGRGESTSMLAGEYRNGKLDVLATQQLPHSLGLMYEELTAHLGFTRSSDEYKVMALASYGQPRFVDWLRDKVFSTGDGGFRTHPINWDAYAPKRAPHEPMWPEHADLAASVQQVLQEVMLDLCRWLHAATGADKLTMAGGIALNCVANTELFDQGPFDDIWVQPAAGDSGTALGAALAIAAEAGPPPDPMTTAALGRGFSDAAIEQTLREAHIRYERPADLAGTVAQALAGNEIVAWFQGRAEFGPRALGCRSLLAHPGYAGNLERLNAVKGREQFRPVAPMVLAERAPEIFTRGPLPSPYMLFVHDVAEPWRERLPAVTHVDGTARIQTVEGADQPLLARMITRFEELTGLPVVVNTSLNTAGRPMVDSPRDALECFGSAPVDLLAIGPFVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFA7</accession>
    <name>A0A231HFA7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47562">
        <property type="protein sequence ID" value="OXR47562"/>
        <property type="gene ID" value="B7C42_00687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="11895" checksum="24DA77779E188C3B" modified="2017-10-25" version="1">MARVVNQPAREDIELTAVFHALSDPARLRIVCDLADRTDEMSCSELTVEMSKSTLSHHLKVLREAGLTVTRVDGTRRMVSLRADDLDARFPGLLRTVVTVAPRPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFU6</accession>
    <name>A0A231HFU6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47688">
        <property type="protein sequence ID" value="OXR47688"/>
        <property type="gene ID" value="B7C42_00813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="57" mass="6181" checksum="EC2DD5A830DB5077" modified="2017-10-25" version="1">MFWKILGVVALVWLALIVIGALVKALFPILMISVVVFGLYLLYKAVSGSNKSTATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSJ7</accession>
    <name>A0A231GSJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000271">
        <property type="protein sequence ID" value="OXR39584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39584">
        <property type="protein sequence ID" value="OXR39584"/>
        <property type="gene ID" value="B7C42_08348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="7096" checksum="FEE85C3357AD0A3D" modified="2017-10-25" version="1">MYVLTTTATRNPALVLAAAVMGSLFGLQRRRTGGITASLLTHLTWSTLMLHYLPPLFLPEPGRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSM2</accession>
    <name>A0A231GSM2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000641">
        <property type="protein sequence ID" value="OXR39545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39545">
        <property type="protein sequence ID" value="OXR39545"/>
        <property type="gene ID" value="B7C42_08387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="39" mass="4268" checksum="56B8DB013F3F3A60" modified="2017-10-25" version="1">MLVWLDGGLDVDREGLIDLLADFTIAMIERLPAVAVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSN9</accession>
    <name>A0A231GSN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-nitrophenol 2-monooxygenase, oxygenase component</fullName>
            <ecNumber evidence="1">1.14.13.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nphA1</name>
        <name evidence="1" type="ORF">B7C42_08334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.29" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000184">
        <property type="protein sequence ID" value="OXR39598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39598">
        <property type="protein sequence ID" value="OXR39598"/>
        <property type="gene ID" value="B7C42_08334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018601">
        <property type="term" value="F:4-nitrophenol 2-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="50" mass="5797" checksum="4221B8CDD9DEE269" modified="2017-10-25" version="1">MRFQTLFAYQAQGLDKRLEGFAEQCMAEYDLDGWTRPDLIGNGDLSIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSZ8</accession>
    <name>A0A231GSZ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000092">
        <property type="protein sequence ID" value="OXR39675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39675">
        <property type="protein sequence ID" value="OXR39675"/>
        <property type="gene ID" value="B7C42_08258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="20934" checksum="C5C2760A8E2AFC71" modified="2017-10-25" version="1">MRARDRLDQAFIWTFEGSSSSSSPSAASSAASSCTSRSCRRRARSSARSLRARSGRSSAITPGAITMRGRGPSCPSQWGTDWKRPAAASKSSGVGNRGAHRSPKSGPLPADSLTREVLAHITSPGPPGALPASACGTSGASLLVAILIGSNPSTDGPGQGVVVGFDLEAPPVTAGRGLITFTTGKTSISEPGSLCATRDLGQERAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT83</accession>
    <name>A0A231GT83_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000059">
        <property type="protein sequence ID" value="OXR39830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776937.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39830">
        <property type="protein sequence ID" value="OXR39830"/>
        <property type="gene ID" value="B7C42_08092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="117" mass="13180" checksum="C7DCAB8264F46BD2" modified="2017-10-25" version="1">MYVFDTMARMPDTSVPAAQDFLVVDDLDNGASNLPLPLERRTTGAWAGKYSLGFMAPFSIHVWQDEHSGFRDSDSFSTAIELRITVHWSLWWEEASPGRALLDAAIDRLHQRGWSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTB3</accession>
    <name>A0A231GTB3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase</fullName>
            <ecNumber evidence="2">4.2.99.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">menH_6</name>
        <name evidence="2" type="ORF">B7C42_08072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.20" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000056">
        <property type="protein sequence ID" value="OXR39860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39860">
        <property type="protein sequence ID" value="OXR39860"/>
        <property type="gene ID" value="B7C42_08072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070205">
        <property type="term" value="F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="32183" checksum="0A5BDA239BDCA3FD" modified="2017-10-25" version="1">MMTHSDPHVLTIGTDDGVRLAATRLGRSASAATLVYVHALGHERGFWSPLAGRVHQQLSGAVTQIVYDQRGHGESGKPAPRQITTLRRLAEDLDTVLAHASGPVVLVAHSTAAQLVYAYATIHREPADRLGGLVLFNAISESLALPRYLHTWPKRLIWLRRHRSLDAVTAAGEAMLAYRLGRTGHLFAPNAGAHPRVTIDILGTHLGFGLHVKAAEALSRIPAVVLAGERDTVVPLQHAVGLADALRADYDIVAGAGHHLPRTHLERATDTITTIVDHALRLHLERPAHAAENERGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTB5</accession>
    <name>A0A231GTB5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000055">
        <property type="protein sequence ID" value="OXR39867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39867">
        <property type="protein sequence ID" value="OXR39867"/>
        <property type="gene ID" value="B7C42_08064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="428" mass="46278" checksum="EF3507A677114F69" modified="2017-10-25" version="1">MKREAFAAHTGVSVEAVRKWERRRETIVLSVPYAARMDRKLREAEAFVVERFWSLLAGRDASGAARSEGERAPELEGADHMFVPAHTASGEVVLMSIPRRTFMAGVGVGAVGVVVDRAVSGIPLAEAFAGSDIDHAKFFLDKRMNIIEADNVYGSASTLAEVLDAIARMQALRQAKVVDSQRVLRLLALYAETAAWQYQDQRMFEQAQHWAEKALTWAHQLGDDYCIGMSLVRMSQLASDRGDGASSGELAEAAKRAAPECSLFAAAAVAYGAHALSLEKNAAASARAYDDARLLIEKADADPVWGFFLDHSYIDAYQAHSLVALGDHHAAAAQFDAATARMQSGYPRDRGVYLARAAVAHMTAGDIEPAASAGKQALRIGIATNSGRIMEPVITLAALMDPHSTQPGVGEFVEEFEQWKVASCPSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTF2</accession>
    <name>A0A231GTF2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Denitrification regulatory protein NirQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nirQ</name>
        <name evidence="3" type="ORF">B7C42_08070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000056">
        <property type="protein sequence ID" value="OXR39858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39858">
        <property type="protein sequence ID" value="OXR39858"/>
        <property type="gene ID" value="B7C42_08070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="150"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="382" mass="39596" checksum="7E91FD9E70BD1FDE" modified="2017-10-25" version="1">MTSPTATAPAASARLGNGELRRMVARVLADHPGIEYSPREVAKLISRSSGAVGNALKTLTAAGQAEQTSAKPLRYRATAASAAAAAGATAPTSAAPATAPAARPRKGTPSAAAPAPVAGRTVPRPNGQDYHLRKLAGRSDVDVLRTMRTAEVPVLLYGPPGTGKTSLIEAAYGDLLTVQGDSDTTVADFVGEYTQNPDGTFVFVHGPLVRAMREGRVLFVDDATLIPPTVLASLYPAMDGRKEIVIKAHGGEVVKAEPGFFVVAGHNPGVHGAILSDALSSRFAFQVQVGSDYDLAEQLGVEPKAVKVARNLATRKSAGDIGWALQLRELLAFKKIAAATDLATAAANLLGTAPEDDREIVATVVRSVFGTAYQPLALGPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTF5</accession>
    <name>A0A231GTF5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782319.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39896">
        <property type="protein sequence ID" value="OXR39896"/>
        <property type="gene ID" value="B7C42_08042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="18616" checksum="B52E9BF8F292184E" modified="2017-10-25" version="1">MKTITEIVGDTATIRVVPPEKHERLAALLIEAAGDRKREVKSISTGGRGFRVPLDIAEDAGLVSYEIVITDDENDSGQAETQFAEGGVIPDDATAVNDTDSPIAVQTAEERDQTVPGPAEFDVPAPEPGPADATPVADDSPAEETAEEPAKPVARKSTSRAKSKPTTKAADENAGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTI0</accession>
    <name>A0A231GTI0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043551.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39937">
        <property type="protein sequence ID" value="OXR39937"/>
        <property type="gene ID" value="B7C42_08000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="128" mass="14975" checksum="9B013EC355616EC4" modified="2017-10-25" version="1">MSTAYLDPEGRRYGVPTWPWRMAPQHLRTWRQLDAEGRRPTSEWQAQVRGRGRRQAYLYDAQQTRPKQEPTEAQLESLRIARWVRSAQACERRGIDAEDMRELIEAARADLAARRAAQSRAVDRGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTX4</accession>
    <name>A0A231GTX4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-hydroxyethylphosphonate methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.308</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fom3</name>
        <name evidence="3" type="ORF">B7C42_07870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.308" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782755.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40066">
        <property type="protein sequence ID" value="OXR40066"/>
        <property type="gene ID" value="B7C42_07870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="211"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="489" mass="54630" checksum="FB6669AB02197675" modified="2017-10-25" version="1">MESSTAQPHPDLLAGADPKRNLDLLLVNAPLRDYSFRPRVNNFTLPVLGMAYIATYAAQQGFNVAVLDAEAHGLGISETIDVVNQASPRWAGMNLLAPTYDISATIAAGLDPAISVILGGHQAKAMPTDILTDPRMSRCAALILGEAETRVAELLKDHHYRTRLPGVMWLDAIMKTPVTGGVPGMQHHLAPNIDTMPFVDRAYLRQDPHWEDGRWEANMVGARGCPYNCTFCGAAVSANPDITIRVRKPHNIIEEMTQLRERHDVTAFRFVDDLFLGWKKVIETMMNGFRSERIGDWARWDATGRINVLDHTSDAMLDTLAANGLREVALGIESGSDRVLRYIDKRITPEMAVRVAHRLLIRGINVKGYFILGFPGETKQEIDDTETLVHRLWDATDHLPGTFRASVFEFRPYPGTPEWSRLMATGRYTPQRLLDYTPVDLTAGGVDETMYGRDEFNFSTGIQLSEAPISYIRDKLIYLGRTQYARTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU45</accession>
    <name>A0A231GU45_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4,5:9,10-diseco-3-hydroxy-5,9, 17-trioxoandrosta-1(10),2-diene-4-oate hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hsaD_9</name>
        <name evidence="2" type="ORF">B7C42_07803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778633.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40139">
        <property type="protein sequence ID" value="OXR40139"/>
        <property type="gene ID" value="B7C42_07803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102296">
        <property type="term" value="F:4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="31864" checksum="BA78A9F466BB32F1" modified="2017-10-25" version="1">MSTAVETDAIPELRELRTEHGVLRYRESGDGPPLLLLHGSGPGVTGWRNFRGNLDTFAQHYRTYVLEFPGFGVSDDFGAPHPMVSARTAVTAFLDGLGLDRVRIIGNSMGGFVATDFALAAPERVERLVTIGGIGTPVFSPQPGEGIIRLSEFVDNPSKEALIAWLRSMVFDQALVTDELVQERWDQATDPATLENSRRMYGSAALARMAESMRSADVTPGWAELRRLTVPTLVTWGRDDRVSPVDMALIPMRLLPHGEIHIFPNCGHWVMIEQKQAWEAAVLAFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU75</accession>
    <name>A0A231GU75_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40177">
        <property type="protein sequence ID" value="OXR40177"/>
        <property type="gene ID" value="B7C42_07759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="212" mass="22814" checksum="37767FE6A8EFB934" modified="2017-10-25" version="1">MPRRESDRDYGGVSALTRRVERRKKLIAAGRRVWGTRGVDGVSVRGVCADAGLTSRYFYEHFAGRDELITDVAGEVWADILGLLVSTGLRTEGGLEPRLQEALTTLFDLLIDDPSVHRIVTDVTTASSLTNLRSEALDQLIDSVLQFGPALMDVELPGPAQVRHGAIFIVGGITAILQDWLLHSTESASELAATCTRLTMATITAAGLEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU92</accession>
    <name>A0A231GU92_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40051">
        <property type="protein sequence ID" value="OXR40051"/>
        <property type="gene ID" value="B7C42_07855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008653" evidence="2">
        <location>
            <begin position="33"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="429" mass="43512" checksum="32CF806D288320B5" modified="2017-10-25" version="1">MSSLPVRFARAFVIVLVWLAAVTGLLAPSAVADPIDCDALIAQIEAHNQAAAVHNANPPNPKDPAAVAAYNAEAERGNAEAAALNAQAQQCRSQGHDVPQVGAPPPNTPNPAPTPPPGSPAPAPGPAPAPAPKVPAPPALPPGGGAPGLKASPAAPASPVVGQPLPVPVRPSQILSPPTIRPGTAYNPATAAGASLKAPSPLPGSVATNPRFTPAPNEPMQAPGLNTPAGQPGMTSTQQEFFASAPRLLDVAKAIPAPSNSGNGQIYRLPDLTGSGATSNSGPALYAGPGNTRAIAGPLDSLGRPTGSYGYLDAAGTASPRTGVPTINVPGATGAYQRGHLWPNQYGGPGNVPQFLAPELGTTNTGAMRVYERYLGQVVQGQVAGVPAQNVTYIKVPIYTDDKVIPDYYLLQAWGDQGWNLPPTYIQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUF6</accession>
    <name>A0A231GUF6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putrescine importer PuuP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">puuP_2</name>
        <name evidence="11" type="ORF">B7C42_07757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40175">
        <property type="protein sequence ID" value="OXR40175"/>
        <property type="gene ID" value="B7C42_07757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR40175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="953" mass="102345" checksum="9ABEE5581F0BA737" modified="2017-10-25" version="1">MSTQYSGTRSEVGAGSGTGRQRTLTTGRVVVLVVAAAAPMAALIGTMPLALIRGNDIVLPAAYLLAGLGLLCFCAAYAAMTRRVSNDGAFYLLVARALGKPLGAAAGYVGTLGYAALAIGLPASFGYFTSLVLQSTGVNVPWWVCTAVAVAVVAVLGYRNVDLSARILAVLMVLEFAVLIVLDLLIAGDRGGAAFPLQAFAPHRVLSGSLGVAAMFAFTSYVGFESAALYGEETKNPERSIPRAAFTAVGVITVFYIVTSLILIGGAGGDAAPALAGSEVGDFVFTLAQQYGGTVLYDATAVLLCTSLLASYLALHNAASRYVFALGRERFLPRALGRYHPRHLSPHAASIAVSASTVVVLAGLGAAGADPYLIIAAALIGLGTLAIVSVQAITALAALVFFRRRSDRHWFSGVVAPVFGVLGLGTGVVLATANYSVLTGTTNLAVDLIPVLLIVAAGAGIAVAVRLRSTRPAVYAAFATSRLRKRSDAALARPAVDYTRRYVIVGGGPTSMIMARALMKEGVPFDWFERHSDFGGIWDMDNPGTPMYESAHFISSKYTSGFYGQPMPADFPDYPAWWQIRDYIRQFARDWGLYDRVTFDTAVEWAEPLPGDRWRVRLSDGRVNEYDGLIAAPGVTWHANAPGFTGMETFRGDIRHSVTFRSGQEFLGKRVLVVGAGNSGVDIACDAARHAERAFFSVRRGYRYFPKHIGGLPTDAVVNGILEPPKGLSLSADLDQLIDSLVGDLTRYGLPAPDHNALSSHPIMNSQVLHYLAHGDLIAKPDVDHFTETGVVFTDGTSESVDLVLLCTGYEYKIPFLDSGLFTWKAGHPQLYLNVFNRDYDSLYVLGFIEFADAAYKRFDEMAQLVVMDIRARETGEHRDRLRGLKAGDHPDLRGGIDYVDSPRHANYVESHTYQNYLAELRDRFGWPDPDHSYYDAIRPVAVVAAADSEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUK2</accession>
    <name>A0A231GUK2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH IS21-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_07642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40304">
        <property type="protein sequence ID" value="OXR40304"/>
        <property type="gene ID" value="B7C42_07642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="33110" checksum="CE6BB7132906A7FC" modified="2017-10-25" version="1">MARHRGSLAAAVAEPEPPQRPDIAEVSAELQYRPVAPDQRKDRTAVRTRERWAQVHALLDQGTSILAISRQLGLARGTTRRFARAESADELLVNNRTGYRISVLEPYKPDLHRRWNEGCTNATQLFQEIQARGYQGSEKMVRTYLQPFRTRAHIPDPRPKPPTVRKVVAWIMTNPDTLAAEHRASLDSILEVSPELAALTRHVREFAEMMGQRRGRDLERWMAAVDADDQPALHSFVRGLRRDQDAVTAGLSMSWSSGTVEGHVNRIKMLKRQMFGRAKTDLLRKRILLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUM4</accession>
    <name>A0A231GUM4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase</fullName>
            <ecNumber evidence="4">1.14.99.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ncsB3_7</name>
        <name evidence="4" type="ORF">B7C42_07590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.49" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40329">
        <property type="protein sequence ID" value="OXR40329"/>
        <property type="gene ID" value="B7C42_07590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="44257" checksum="6F796E8DC6300522" modified="2017-10-25" version="1">MAIHGESFRRDPHAVYRALRRRYGTLAPVELAPGVPATLVLGYYTAVRILHDPEHFPADPRPWQQSIAGDCSLRPMMEWRPAARYSSGAEHARYRAPSVAAIEGVDLHAMHARVERIATALVDAILPAGRADLASQYAFPLVLAVLTEVYGGSEDIVGQVAAGTKERFDSDGTAAPGMDTLTAALTDLVPFKRAHPGDDITTRLIQHPARLDDREVAAQLMSFAGAGLQAVPDLVCNALRLMLSDDRFGGSLLSGSLHTRDALDAVLFNDPPMANFCTTYPRQPILVGNMWLPAVQPVVISIAACNNDPEIASNDTARSGNRSHLAFSTGPHACPARTVAYQIAQDAIDYLLDLIPDIVLAVPADRLEYRPGPFHRALTALPVVFPRAQRSGAPTPHRTDPRHLPPKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUX7</accession>
    <name>A0A231GUX7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40430">
        <property type="protein sequence ID" value="OXR40430"/>
        <property type="gene ID" value="B7C42_07488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="31647" checksum="907CE76DB6FB207B" modified="2017-10-25" version="1">MTTEITPTRLSSGFSWTESPRWHNGKFYFTDLYSARVVTVGPDGDATTVVDLSDRQAPEGQRIVASGIGFLPDGRLLINSMFERLILVHDGNTTSVYADLRELAISPINDMVVDTAGRVYVTQLGFDLFAGESPKDSPLLIIEPDGSARVGDEAGLFMGANGIAITADGGTLVTAETYISRITALDIAGDGTLSGRRTFADVGPDTYPDGLCLDEEGAVWAGLAAAGRVIRVLEGGVITHEVRPPAAEAGVSTACGLGGVDRRTLYICCGFEVMDFAKSVDEGLGSIWTAPVPISAGAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV17</accession>
    <name>A0A231GV17_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetate operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iclR_2</name>
        <name evidence="5" type="ORF">B7C42_07476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40418">
        <property type="protein sequence ID" value="OXR40418"/>
        <property type="gene ID" value="B7C42_07476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="29358" checksum="B5B290980CC580F4" modified="2017-10-25" version="1">MTTTLEAPTAMIDRVASVLEAFVEERPLTLAEVARRSGLPRSSTHRILQRLVELAWVEREGYEYVLGIRMFEFGSRVRRQRSVHEAALPVMTDLHRRSGMTVYLSTIDGAEVIHLERVGLGPRGGGQWGIGGRQAVETAAPGHALLAVMPRPAWPELRFADAPTCYSVKSRLQLDRELQRTRDRGGIAVDSQGNTLGVTVVAAPIRSADQHARLAVSVCGPTHTMRTTSAVNAVRSAAMEIWYAAMGVPRSRNRLQQMDRLPVGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV40</accession>
    <name>A0A231GV40_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40341">
        <property type="protein sequence ID" value="OXR40341"/>
        <property type="gene ID" value="B7C42_07602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="463" mass="49689" checksum="C21EC0DD745C70ED" modified="2017-10-25" version="1">MTTAPNAVAGHGWAGALRAFRRGLGLNQQQFAETLNEAGAALGLKLSCDQQHVSRWEREVIRRPDAEYVLALQRIGGPVPNAPAADDRALPPSDVSPYSSQVAGATTGVVERRRFLAAVAAAATAGSVAELAPWLPSFYPQPGPTPGRAGPADVQCVREVTAGLRGLDQRHGGFAVLDSATGLLRWSSELLHRCGDHETTTAMSVALADLSRLTGWAYYDTGDQARARSYLTLALTYARSAGADSLAASILYVLGRISLIECQPREALRMFQLGQMSAQDASNIGESARLYSNEAWAHAMMGNRRQMHDALGRAEHEISRVNADPDPWTEVFFAAGEHAGLTSVIYNEFALTADRNLREQYTALALDRAVESLSRSTSARPTRSVLFDQTTIAACRFRLGDTDSAVAAAGAALDLTQEVISARALSRLSSMAGAADPFRKKSHVSEIVHQIRQLAPPAPKTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV42</accession>
    <name>A0A231GV42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein Stp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">stp_16</name>
        <name evidence="7" type="ORF">B7C42_07506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40448">
        <property type="protein sequence ID" value="OXR40448"/>
        <property type="gene ID" value="B7C42_07506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="494" mass="52172" checksum="0AB0A824D7DF36F3" modified="2017-10-25" version="1">MGTKTSASEEHSFPGPRRRRSTAYYTMVVIAIALVVGNANFEFTLINGAFTNIAEEFRTKDVALVFTVVFVASLVFLPISGKLADIYGKKNVLLAVSVLFAIGCILCAVAQTYWIFLAGRVFQSAFIVAYVAGYGLVRDILPARMVPVGVGFVGLGTGVAVIVGPLLGGYLIDNFGFRSAFWFELGYAVVSGVLVLLVVPESGVRVRRRIDVLGGLLLGGGVAILVFGVVTPRWLTVAIPASAILLVLFGFVERRREEPLIDMRLLRETKVWLTLLTSAMAICAVTAGPVLLSEYTRIPQIPGVLDRGLGWTALQFGLYDGLTFGLVGALAGLLAGWVCRRFAPRTALFVSITGTFIALTIGLIPIASAGLIITIAVFQGVGLGFLYASANNLVIEAVPAESQGIATSMLYTAFGVMNAVGTALIGRITASQSVPAGDGSAALIITEQGFRYSFLLLMGTSVIAFALALIMRHGRTPATGGALPEDGQALIHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV62</accession>
    <name>A0A231GV62_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_23</name>
        <name evidence="3" type="ORF">B7C42_07406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780079.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40468">
        <property type="protein sequence ID" value="OXR40468"/>
        <property type="gene ID" value="B7C42_07406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="450"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="553" mass="60268" checksum="DF699FAFCAFAEC7C" modified="2017-10-25" version="1">MGRVRPVSYTHGVWDVPLLGETIGANLDRTVAVHGDRDALVDRVTGVRWTYREFAAEVDAVALGLLASGIGKGDRVGIWSPNRAEWTLVQFATAKIGAILVNINPAYRSEEVRYVITQAGIRMLISARAHKSSNYAEIIGRVRPECPELERVVLFDSAEWEALVAAGRAADPARLAEAGARLAADDPINIQYTSGTTGFPKGATLSHHNILNNGYFVGELCGYTEADRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAASFEPRATLAAVAEEGCTSLYGVPTMFIAELADPDFESFDLSSLRTGIMAGSPCPVEVMKQVIERMGMAEVSICYGMTETSPVSTQTRRDDTITQRTATVGRVGPHLEIKIVDPDTGLTVPRGEPGELCTRGYSVMLGYWNDPDKTAEAIDAARWMHTGDLATMDDDGYVAITGRIKDMVIRGGENIYPREIEEFLYTHPDILDAQVVGIPDPKYGEELVAWIRMREGAAALDAQTLAQFCGGRLAYYKIPRYVHVVDEFPMTVTGKVRKVDIRSTSVRLFGGPEQDQQQTGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC1</accession>
    <name>A0A231GVC1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40522">
        <property type="protein sequence ID" value="OXR40522"/>
        <property type="gene ID" value="B7C42_07461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="38" mass="3976" checksum="49E3F4E39F151F31" modified="2017-10-25" version="1">MDPLTVLSLINLGSAIVVNVLNIASDVLAFAAPYLPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVI8</accession>
    <name>A0A231GVI8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative iron export permease protein FetB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fetB_2</name>
        <name evidence="7" type="ORF">B7C42_07283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909776.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40598">
        <property type="protein sequence ID" value="OXR40598"/>
        <property type="gene ID" value="B7C42_07283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="PTHR30028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00245">
        <property type="entry name" value="TIGR00245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="28685" checksum="813F0008C130E9AE" modified="2017-10-25" version="1">MNGAVGWGGLATSLALVVVAAGISLWQRLGLERQILWSAARALVQLLLVGAALALLLEPGRSLWWSWAWTAAMIAYSGDVARRRAPEVPRLATLAITAFAAAAVITLGVIFGLRVFPLQGRTLVPIAGMMIGNSMTATVLVARRLVDELRDKRDEVEARLALGQPSRQAATPYVRTALRSALSPQIETTKATGLVFLPGAMTGLILAGVPPVQAVLVQAVVMFLILGAVAATTVVIALGLVHRLFTPDHRLLPLARRPDTISPGKPGARTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVZ9</accession>
    <name>A0A231GVZ9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40803">
        <property type="protein sequence ID" value="OXR40803"/>
        <property type="gene ID" value="B7C42_07087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="30524" checksum="94A28AFDB33D4A1B" modified="2017-10-25" version="1">MSDNELGLFLRTRREAVTPAEVGLPAGPRRRTPGLRRAELATLAGVSVEYLIRLEQGRDRHPSTGVLSAVADALRLSPSERVQLHRLVKSADPGFSCTGGALPNRRVRPAVQAILDRLAPAPAAVFNRLGEILSCTDGYRALVGGTGLLDHGLPAGYPRWLFTDPRARVVYPEWDHRADLAVATLKAGPFRSDPAIAVLADELTLLAGAEFTRRVADIAGLPDTSGISRMDHPEAGPLRLAYERLDLSADDDQYIQVQLPADEATAAALDALLGRRPGGLRAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW05</accession>
    <name>A0A231GW05_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40758">
        <property type="protein sequence ID" value="OXR40758"/>
        <property type="gene ID" value="B7C42_07182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase_6" evidence="2">
        <location>
            <begin position="240"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="418" mass="44790" checksum="DE6B4F675BD315AF" modified="2017-10-25" version="1">MELHQLRYANPGSWQAAADDLLAAAKDCEEAVAEIHANGSRRLEESWTDYLGELVRERISDVTGKLEEIGVLLRGAVTALDTLEDAARIAQAQAGSAIAAGTVAGLDLEGDVLVVPAGHHDPETAADDCRRYNALIKDAIDAADRADQEVAGALRKLNINVDTSSLDDALRQQSAAVADALDAIRETLPQGQPADVVKAWWDSLAVDRRKQLMLAVPVELHDLNGIPDSVKKELEGSNGYNAVKAVQFARDYANDTSIDKFQNNCANFVSTTLASAGLDYKGTLTTDSDGWNRSRAAGINFDPPGPGSLQGLSHSDTWFNAEKQKNFFLNNGAQEVGTAGAKPGDLVYWEHTQNVGDYKAGEAHRTAVVTAVLPNGDILYSQHTTNGKDFSLTDRIGFSNQDGGHRTSGSLGRRRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW65</accession>
    <name>A0A231GW65_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-[(3aS,4S,7aS)-7a-methyl-1, 5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD3_7</name>
        <name evidence="3" type="ORF">B7C42_07096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40812">
        <property type="protein sequence ID" value="OXR40812"/>
        <property type="gene ID" value="B7C42_07096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="61"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="466"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="553" mass="59406" checksum="D0876FF81A5103B5" modified="2017-10-25" version="1">MGVGIGSVLHGVARKAVEVTEAVRALNVLRERGFIDPRNLGETVLSAKEGRRLGPQATMVRHAARMWPQRTALIDEHGSMTFRELDDNSTRLARGLQSLGVEPGTVIGILARDHRGLLLAMAAAGKAGARLALMNTGFAKPQFAQVCEREHVKVVLHDSEFVGLLDALPPELPRVITWVDDGAELPTGAITIEELIAAHPPNELPLPAKPGGFVILTSGTTGLPKGAPREAVSPISSAQIADRIPFPPQGTMLIVSPIFHSTGQATWLVATALGATTVMMRRFDAERTLALIAEHDVDLLVAVPTMLHRMVELDPAVRARYDLSSLKSIVLAGSALSPELSVRAAEAFGPVLYNLYGSTECAVATVAQPADLAIAPGTAGRAPITCEVVLFDENDKRVHGANVKGRIFIRSGAPFGGYTDGRHKQIIDGYMSSGDVGHFDEHGLLFVDGRDDDMIVSGGENVFPQEVENLLLERADIFDAAVVGVDDVEFGKRLRAFVVPEPGATLDPDEIKAYVKGTLARYKVPRDVVFLDDLPRNATGKLLRRALVEYQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD4</accession>
    <name>A0A231GWD4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase sigma factor RpoS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoS</name>
        <name evidence="1" type="ORF">B7C42_06903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40937">
        <property type="protein sequence ID" value="OXR40937"/>
        <property type="gene ID" value="B7C42_06903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="44131" checksum="5050114ED24CAABE" modified="2017-10-25" version="1">MTTNRIEEIQAGLLDDLRDGLSFTSEQMTDTLADMVAAQAEERPRDGELLTRRLGLDGARPETLTLLGARFELSRDRVRQLYTRAAGQLLRRVQATGYPDPAVFAEQYPVGWGDQRLTRTLLIETYVGDCDIAAQDLAYLKLRLAGHSLIDAKRVAGFVYQRIAGWQQRGRWHLDRPRVTEPTAGQLLPLLRRVDWPSGDPDDLPELPITTVDADDDARGHMFAEKLGRETTFDTALQARLLRVLDDSEQVDSYTERPVAVDFTVDDVADSYCPTVAARLTDGRVLLIDVVALGQLGLHANRMRLAAARTQAHARGWGWLVFTGSRLGEPDLLRHTVSARSENILRNRIATGAVHWPEFRGLADETGLEPVDLIALVLRHGWRWDRAPFRLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWR4</accession>
    <name>A0A231GWR4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-[(3aS,4S,7aS)-7a-methyl-1, 5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD3_6</name>
        <name evidence="3" type="ORF">B7C42_06988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41022">
        <property type="protein sequence ID" value="OXR41022"/>
        <property type="gene ID" value="B7C42_06988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="274"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="673"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="770" mass="82718" checksum="E0C91AACDD2F078E" modified="2017-10-25" version="1">MWRETAAGSTIEAAGDVPFRDATHITPRTRGGELTTAPAGAPGIVTRHLLREVDPGYKGIPAGALEEPAREKCKKLATEVFDTAVELPVERSAVWELLVDPQLYPRIFTGIGACERLETVAGPPLWQLRIGTADTEIRTLSLTVRVGPRGEAFELYCAATGSFASVRLRDIEDGTRAVITCFAAGRIHPVAARTSTAGAQAWLDAGLRRLRELVTAAPTSVVVNRENTPLRRHADVARHILGTGVVRTARPDRSVGQLRGLARWGFNLAGGYAAAAAHSPTRIAVVDDRRSRTFADIDRRSTALAGGMAGLGLRTGDAIGLLARNHAGMVETMVAAGKLGVDTILLNAGLSARRIEEIVQRHRLAHVFVDAELEELIQYLHSDIVRIATDDGAPGRTTIEDLITQGDNGFDKPARPGRLIVLTSGTSGTPKGARRPHAKGFATVAALLSRIPLRMNDTMLIPAPLFHTWGLAALQLSTALRATVVLPEQFDARDTLRRIAENRVGTVILVPTMVQRILDLPTHVRARYDTSSLRIAASCGAPLAGATVLRFADNYGDVLYNIYGSTEVSWATIATPEDLRTAPTTAGRPPLGTKIAVLGPNRKPVPIGATGRIYVGNHMLFDGYVNSAPPDETDGMLDTGDLGYLDADGRLFIAGRDDEMIISGGENVFPRPVEEALSHLPQIADVAVVGVPDHEFGQRLAAFIVKREGSGLDPDMIRTYVRNRLSRFSVPRDVTFLSALPRGETGKVLKRLLIGGNTELTGPFHPAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWU1</accession>
    <name>A0A231GWU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776931.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41090">
        <property type="protein sequence ID" value="OXR41090"/>
        <property type="gene ID" value="B7C42_06860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8733" checksum="9604EFDB88C790A0" modified="2017-10-25" version="1">MHFADPQPLDKDVQLRIWLGGMAFDFRTTRTAALTFFTEWGRRRREAIELVTETPSDTSLLPRLPCERLFHDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX57</accession>
    <name>A0A231GX57_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol oxidase</fullName>
            <ecNumber evidence="3">1.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">choD_5</name>
        <name evidence="3" type="ORF">B7C42_06595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41197">
        <property type="protein sequence ID" value="OXR41197"/>
        <property type="gene ID" value="B7C42_06595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="495" mass="53563" checksum="F8335D48526E5A76" modified="2017-10-25" version="1">MGGGSLNYANTLYVPPDPFFLDTQWRDITDWRAELTPYYERAQKMLGVVRNPHMTPADEVFKAVAEDMGIGDTFVHTPVGVFFGEPGRTVSDPYFGGIGPDRTGCVECGDCMVGCKFGAKNTLVKNYLYLAEKAGVQVIPMTTVTALRPAPGGGWDVMTERSGAWVRKDRRRFSATHVVLAAGTLGTQTLLHRMRDQGVLPDISDRLGVLTRTNSESVVGAVGRKVRDDRDLSRGVAITSSVHPTPDTHVEPVRYGKGSNALGLLQTLMIDGGGRVPRWLRFLWAVLLHPMSLARVFNVRRMSERSIVTLVMQHLDNSITVRTKRGLFGGRTLTSEQGHGEPNPTWIPVGNEFTRRVAAELEGDARGSWGELINIPVTAHFLGGAVIGADRDSGVIDGYHRVFGYPTLSVVDGAAVSANLGVNPALTITAQAERAAAFWPNKGDLDTRPDQSAGYLPIAPVAPKHPVVPAESPAALVTLPVPTIRRDSLGATRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXL7</accession>
    <name>A0A231GXL7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Multifunctional 2-oxoglutarate metabolism enzyme</fullName>
            <ecNumber evidence="16">2.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">kgd</name>
        <name evidence="16" type="ORF">B7C42_06526</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.5" evidence="16"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41383">
        <property type="protein sequence ID" value="OXR41383"/>
        <property type="gene ID" value="B7C42_06526"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="15">
        <location>
            <begin position="898"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR41383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1247" mass="137514" checksum="71865F90E72D4B09" modified="2017-10-25" version="1">MSSSTSQFGQNQWLVDEMYQKYKQDPSSVDESWHEFLADYTPESPGETGNSSPAASAPTAAPSAPATPAPAAPKATAAVSAAAAPPQARGSKPQASTTPAPTSNAAPTKTAPAEPAADESKVLRGPAAAIVKNMSSSLTIPTATSVRAIPAKLMIDNRLVINNHLARTRGGKISFTHLLGYAIVQAVKAFPNMNRHFAEVDGKPNSVTPAHTNLGLAIDLPGKDGSRTLVVAAIKNTETMSFAQFHSAYEDIVRRARDGKLTTEDFTGVTISLTNPGTIGTNHSVPRLMPGQGAIIGAGAMEYPAEFQGMSDQQLAEIGIGKLMTLTSTYDHRIIQGAESGDFLRTIHNLLISDEFFDEIFHGMGVPYEPVRWRKDIKERGVDKSVRVQELIAAYRSRGHLMADTDPLRLVKDKFRSHPDLDVTQHGLTLWDLDREFNVAGFHGQERMKLRDVLSVLRDAYCRHVGVEYTHILETEQLQWIQDRVEQKHEKPTVAQQKYILSRLNAAEAFETFLQTKYVGQKRFSLEGAESTIPMMDAVIDQCAEHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNMNPAATHGSGDVKYHLGAHGTYIQMFGDNDIEVSLTANPSHLEAVDPVLEGLVRAKQDLLTKEDLVTKGEEARTFSVVPLMLHGDAAFAGQGVVAETLNMSGLRGYRVGGTVHIVVNNQIGFTTAPENSRSTEYSTDIAKSIGAPIFHVNGDDPEACTWVARLATDFREKFHKDVVIDLICYRRRGHNEGDDPSMTQPYMYDVIDTKRSVRKSYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKYPPEPSESVEEEQTVPGTVVTAVDKSVLQRIGDAFLGVPDGFNVHPRVKPVLERRREMAYEGKIDWAFAELLAFGTLIDEGRAVRLTGQDSRRGTFTQRHSVIIDRKTGAEYTPLHNIGSENPGWFAVHDSALSEFAAVGFEYGYSLGNPDALVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSEVVLLLPHGHEGQGPDHTSGRIERFLQLCAEGSMTVAVPSTPSNYFHLLRRHALDGIRRPLIVFTPKSMLRNKAVVSNVEDFTDAKFRSVLEEPTYESGDGDRSKVKRILLTSGKLYYELVAEKAKKNRDDVAIVRIEQLYPIPSYRLNEKLATYPNATDLAWVQEEPANQGAWPFFGLNLPEILPDRFNKLRRISRRAMSAPSSGSSKVHAVEQQEIVDEAFAPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXQ4</accession>
    <name>A0A231GXQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG_28</name>
        <name evidence="2" type="ORF">B7C42_06519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41376">
        <property type="protein sequence ID" value="OXR41376"/>
        <property type="gene ID" value="B7C42_06519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="24001" checksum="96B47C73F318E9CD" modified="2017-10-25" version="1">MAGIEGAVALVTGGQRGLGKAFTDELLRRGAAKVYTTARTPKADGDTRIEPLALDVTDADSVAAAARRARDVEIVVNNAGVLLPAPLLTADMADIVTTFDTNVFGPLRVAQAFAPILADNGGGVLIDIHSVLSWAAGAAAYGASKAALWSLTNSLRLELAAQRTQVVGVHLGFADTEMVRRLPGDKIAPSVVAEAVFDGVLRGDTEVLVDDVTRGVKAALSGPVEGLALAIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXT6</accession>
    <name>A0A231GXT6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41409">
        <property type="protein sequence ID" value="OXR41409"/>
        <property type="gene ID" value="B7C42_06552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="8227" checksum="564522661C94D94A" modified="2017-10-25" version="1">MGAYSTSPTRAVSPGDSAAAGSGRSAWTITSRIAAWLIFLGGLVGAVLGIAGLRVEITVAGLILACTAGLVLLKLRADGQQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXW8</accession>
    <name>A0A231GXW8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase SadH</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sadH_5</name>
        <name evidence="2" type="ORF">B7C42_06514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780451.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41371">
        <property type="protein sequence ID" value="OXR41371"/>
        <property type="gene ID" value="B7C42_06514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="29982" checksum="B0E18347B6EE16CF" modified="2017-10-25" version="1">MSNDAYFTGKVCVITGAGSGIGRALAENLARRGAKLALSDIDTEGLAETVRRVEALGAQVKSDRLNVAEREAVLLYADEVKKHFGVVHQIYNNAGIAFHGEVVDSQFKDIERIMDVDFWGVVNGTKAFLPAIIESGDGHVINVSSLFGLIAVPGQSAYNAAKFAVRGFTESLRQEMMARKHPVKVTCVHPGGIKTAVARNATYAEGIDAQKFSSFFDKQLALHTPEMAAQTITEAVRKGHGRVLIGWEAKALDLFVRTTASYYQRIANVVNSRFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY43</accession>
    <name>A0A231GY43_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mshD_7</name>
        <name evidence="2" type="ORF">B7C42_06411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41519">
        <property type="protein sequence ID" value="OXR41519"/>
        <property type="gene ID" value="B7C42_06411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="18751" checksum="350146EF45BBF11A" modified="2017-10-25" version="1">MGCGAHPGEVILVEPMSGPADAAAFKELNLEWITSLFGVEPADLATLDNPQQIVADGGQVLIARDGADRVGCVALVAEDPGVFEISKMAVAPRARGAGIGRLLLNAAIDHARASGATSLFLASNGRLADAVHLYESVGFVHVPPEELRPIPYDRADVFMKFDLAHQISAVLTLRETIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYE7</accession>
    <name>A0A231GYE7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41551">
        <property type="protein sequence ID" value="OXR41551"/>
        <property type="gene ID" value="B7C42_06444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="29871" checksum="FFB7BE05FA5F4D03" modified="2017-10-25" version="1">MRSTIVHYLHSSVAPLLRGSYAETIGRPLFSAAAELTKIAGWAAYDQEEHGLAQRYLIQALRLARAANDRGLGAEILAAMSHQATYVGRPGDAIDLARAARMTARATSSAALESECHLAEAHGHAARQDNSSCAASLSAAERSFEKVDRTGCPEWLSYFDAAYMSAKTAHCFRELGDDARAARFAEQSLQMSSGYQRGRAFNLTLLASARTAEDPLEAVRVGREAVELVSAISSQRSYAYLRELRRRLDRHKGLPEVADFQHEVQILTTRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYL4</accession>
    <name>A0A231GYL4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">tgs2</name>
        <name evidence="14" type="ORF">B7C42_06303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41662">
        <property type="protein sequence ID" value="OXR41662"/>
        <property type="gene ID" value="B7C42_06303"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="304"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR41662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="450" mass="48766" checksum="D9265025830A3783" modified="2017-10-25" version="1">MTLMSPLDSAFLLLESREHPMHVGGLSLFRPSGAEPRSARQLHDELVSGTDQLTSLFRRRPARSLASFSALQWDLDDDVDIDYHVRLLSLPTPGRVRELLELVSMLHGSLLDRHRPLWEVYVIDGLADGRIALYTKTHHALMDGVSAVRTWQRVLSADPDARDCVPPWRSPRRRPDAGPATLLRRSAEAVRMAGRIGTAVPELLSGAYEIARDYPEPRPFRAPHTMFNVAITGARRFAAQSWPLPRLRAVGARTGATVNDVVLAMCAGALRRYLLAEQALPAEPLIAMVPISLRGTTESGAGEGNSVGAALCDLATDEPDPAERLARIHSSMARTKNTMSRLTPLQILGLSAINVAGLASAALPVRLPAPAPPFNIVISNVPGAAEPRYWNGLRLEAAYPASIPLDGQAVNITTISSGGAMHFGIVGCRRSVPHLQRLLTGLDESLAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYV0</accession>
    <name>A0A231GYV0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780822.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41755">
        <property type="protein sequence ID" value="OXR41755"/>
        <property type="gene ID" value="B7C42_06097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011250001" evidence="1">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="216" mass="21456" checksum="83138A9C40ED0614" modified="2017-10-25" version="1">MKLRKFAATSALVIAALGISTGTAFAAPAPAANPDIHYTANVVDKSVVVKTDAGSLTTEGNEFQVRDNQGKVVAGFPLSYQHDGLEYPIAAQIDGNQATLVPSTDRAAAHPAPMLHDVASRSDLDAANQSAINELGIATSIGTLVGTAIGLAGGCALGAVLGTPFLVVPGWIGGCLTGAALGAPLGAAAGLVGVGGISGVLVAIEYFNRINAPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYY0</accession>
    <name>A0A231GYY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenolphthiocerol synthesis polyketide synthase type I Pks15/1</fullName>
            <ecNumber evidence="7">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_06124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41782">
        <property type="protein sequence ID" value="OXR41782"/>
        <property type="gene ID" value="B7C42_06124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="979"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="923"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1061"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1125" mass="117348" checksum="34B7D971692BE98E" modified="2017-10-25" version="1">MSAAPSESAGTGGATPDREQRIAAALRAARERLAEPRPAEPIAIVGIGCRFPGGITDPDSLWDVVAGGVDATGEQPGDRWDVRRFYDPDPDKPGTIYTTRGGFLDAVDMFDADFFGISPREAHAMDPQQRLLLEIAWEAVENAGIAPQRLRGSDTGLFVGFSWRDYDRVAVADVPEAMNAYAGLGNTPSIAVGRVAYTLDLHGPVSLVDTACSSSLVAVHQAVQSLRNGDCSTALAGGVNLILSPFSTMFCCRIRALSPDGRCKTFDASADGYGRAEGAGLVVLKRLSQAQRDGDRIYAVIRGSAVNHDGRTGGLTVPSARAQEAVVRAALRTANVEPAQVNYIEAHGTGTALGDPIEIGALNSVFGAARAPLWVGSIKSNFGHAETAAGIAGLIKAALAVQRGVVPPTLHVREPNPRIDWASGSARVVTETTPWPAGSRIAGVSSFGFSGTNAHVVVEQPPVAPASGTAVPSGLLTLSARTDEALRAQSRRFALALRTADPTQLESVCATANLGRITFEHRLAVVAGSTTAMAAALDAHSAGQWQPSVVTGHVPRGRAVRTALLIGHREPGVEPLDRENYTGSGVFRAAVDECLDATSSRESFRTALFAGLAPHQAQRVPGLADALAFVHRYAITRQLLAFGLRPAAVLGVGVGEYVVAAITGILEPAVALRASVSAAALLGERAVARTDDGALLDAVLRETGARLCGRSGNRYLLEAGPGGREALLDRLRAAGIAATTHAELRDHLGTAVPDLGRPGDPEFTVVSAHTGVRLGREAADPAYWSTRALWPAHLDRAFGTLRELGCTVVAEVAGATLTDLGGHRLTESESRRLTTGTTRGELTRCTAGLFAAGAVDDLRDLHGTDYPRITLPTYPFQRRRYWVEAPGSALGAPSTPAASALAPHAEALGADARDAAETVTLDASRPATTGSGEDRGAASESPVPESPARTGAGATVGDAPAITAVEPARSDADLFLLRRRVSAVVVASIRQVFQMPESDPVDLHTPLQELGFDSLMAIELRTVLGRALALPIEAAFAFEFPTATAQITELTARLTVAPTIPPAPVAQPATSAEPGPEPDGDAAGPHPVPFDIPVSTTRTPLDGLSESDLIALARAEVAALEEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ66</accession>
    <name>A0A231GZ66_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41865">
        <property type="protein sequence ID" value="OXR41865"/>
        <property type="gene ID" value="B7C42_06207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="54" mass="6135" checksum="218159945935C2B4" modified="2017-10-25" version="1">MTIKALTSTSRAANRSPPPPAWTYRLDTRLPRHVDDPVLDTKLNRNTLADNNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZH1</accession>
    <name>A0A231GZH1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41998">
        <property type="protein sequence ID" value="OXR41998"/>
        <property type="gene ID" value="B7C42_05982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="13874" checksum="5F0DC36BBA82420F" modified="2017-10-25" version="1">MTFSQPPANQPQSAGLDKKTSAILSYALGWLTGIIFLFIGKHDPDVKFHASQSIVFFGAVSVLNIVLSIVGSLLGAVGIIFSLAGLVVAVFTVVVWIMAMVQANNTGGVRAALPIVGKFTAPYADRLANSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZL8</accession>
    <name>A0A231GZL8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpA_10</name>
        <name evidence="2" type="ORF">B7C42_06019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778940.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42035">
        <property type="protein sequence ID" value="OXR42035"/>
        <property type="gene ID" value="B7C42_06019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011218490" evidence="1">
        <location>
            <begin position="27"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="348" mass="36956" checksum="A4F045F19AD9D09C" modified="2017-10-25" version="1">MIRRSLPTALLASVLTAALCATPAVADDPPPAPVSIAALTAAAEPAADGAHLLGVEQESDGMLDLRVHSAAMNREIEVKVLRAPDGSAPAPVLYLLNGASGGSEASSWPEQTDIVDFFRGKQVTVVTPMGGNGSYFADWRADDPVLGRQKWSSFLTAELPPIIDSAFHGSGANAVAGISMAGTSVFQLALAAPQLYRAVGSYSGCARTSDPLGQAFVDGVVLRWRGDPLNLWGAPDDPLWAAHDPYVNADRLRGLAIYVSTGSGIPGPFDNPDGPGIHGNTRKLIEQLVYGGVLEAATHNCSIALRDRLTRLNIPATFDLRANGTHSWGYWQEDLHRSWPMFEQALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZT0</accession>
    <name>A0A231GZT0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase</fullName>
            <ecNumber evidence="1">1.1.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hsdA_2</name>
        <name evidence="1" type="ORF">B7C42_05736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.50" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42137">
        <property type="protein sequence ID" value="OXR42137"/>
        <property type="gene ID" value="B7C42_05736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047042">
        <property type="term" value="F:androsterone dehydrogenase (B-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="29839" checksum="5CE79C61FD78B34F" modified="2017-10-25" version="1">MGVYVVTGAASGMGRAAAEKLRERGHTVVGVDLRDAQVVADLSTPAGRRAAIDGVLAQVDGHLDGAILAAGVGPAPGADRPRLIVEVNYRGVVELLDGWRSALARADEAKVVVFGSNSTTTTPLVPRRAIRALLAGDTEKALRALRIFGRNAPSIAYGTSKIAVSHWVRRQATTTQWAGAGIRLNALAPGAVLTPLLEKQLATAAEAKNIERFPVPIGGFGDPGDLAEWAVFMLSPAARFLCGSVVFVDGGSDAYFRAGDWPRAVPLRKLPGYLWRFFGPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B1</accession>
    <name>A0A231H0B1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42305">
        <property type="protein sequence ID" value="OXR42305"/>
        <property type="gene ID" value="B7C42_05504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="566" mass="63002" checksum="DF3BFA21F5386579" modified="2017-10-25" version="1">MTILRDDAPLPNAVDGSAGRGPSFLDIAVATAERHGVCVRPVILEQTDLDTGRRTFVPVPCGATLESKCPPCARKHKALRQAQCREGWHLTEEPSTPRPRATYDHEGLLSYRADLAAALNHAREGQDASEVASLRDEIRWTDEQLTALGMRGNAPAAALDADTGAGEDSAGSDEECSATRSRRSTRRRDDAPDLPRNSVSDRTVGREFGGHYSSMFVTLTMPSYGKVFGDGSARDPHRYDYDRAARDAICCARLFSRWIQNLRRVVGWNVQYFAVVEPQKRGAPHLHIALRGHIPREVLRKVTQATYHQVWWPPTGEMRYPGADVPLWDKRHETFIDPKTRKPLADWDHAVDAIGPEEAPAHTARFGPRLDIQGIAANTDQAREAVGYLCKYLTKSVSEVLRARTARQHDHYDRLHAALCRTPCSPRCAIWLLYGVIPKGATAKTVPGVCKARAHRRETLALPCNRVLTSEKWTGKTLGDHKADRIEFVRRKLAAVGIDKPARDPRRYTWATVAPGTRMPSRAQLLISAIAERVAWRVEYDRAILAAESPPGTENDVGECVRQPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0L0</accession>
    <name>A0A231H0L0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42425">
        <property type="protein sequence ID" value="OXR42425"/>
        <property type="gene ID" value="B7C42_05626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012917919" evidence="2">
        <location>
            <begin position="37"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="40972" checksum="7FCD39774197D259" modified="2017-10-25" version="1">MRLSKSSARIRRPLTVAALFTAVAAASVVAVPHAAAEPAATTMSVTAQPDGWHGMTGGALLDYRTTTSQGAPVPASGAVFLPPGEPPAGGWPVVAYDHGTSGLGMGCSGISNPGTAPYPSGRAKEDRILQYFQSKGFAVVAPDYLGLGAFDTGPHPYLERQSEATATIDLLRAARTTYPQLSRTWIAVGASQGGQAALGTGHLQQSYAPELDFRGTIAVDPESDLEHVLPIAGPWVPNIPQLGDGSTAFIAGVLVGMRETRPDIDVDSYLSPRGRQLLDSIGTLCLDGMIEQVNGASLGDLLSRPLGDPRFTAALTDYLAVPTSGYDAPILLLLNATDRTVPSPLHAALAAQLAANGVDARSVVGTGQHCDLNPQMWAAMDAFVARVQSTPYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Q0</accession>
    <name>A0A231H0Q0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="8" type="ORF">B7C42_05609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42408">
        <property type="protein sequence ID" value="OXR42408"/>
        <property type="gene ID" value="B7C42_05609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="7">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="20925" checksum="406DA4337D32969A" modified="2017-10-25" version="1">MSDVSVLAAQTRTEFGKGAARRTRRDGNVPAVLYGHGEAPKHLAVNAQAFAAILREHGTNAVLNLEIDGKKQLAMTKSVVVHPIRRYIEHADLLIVKRGEKVVVDVPVALAGDAGPGTLVTQEATTVSIEVDALNVPESIEVSIEGAEAGTQITAGQVELPKGAALSGDPEALIVNIIVAPAAEAVEGEGEGEAEGEAESTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0U8</accession>
    <name>A0A231H0U8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42456">
        <property type="protein sequence ID" value="OXR42456"/>
        <property type="gene ID" value="B7C42_05658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012714561" evidence="3">
        <location>
            <begin position="49"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="499" mass="50432" checksum="8AB3DD3CD83E7C79" modified="2017-10-25" version="1">MIATPTPAARRTTRLRPRPVVRRLAAAVLCAATVLAASVCMVPVAAVAAPQQPGCAKVTAVLVPGARDTHLDTDTDTASASGAPSSVLDPVARNLQARYGSDLAVRTVPDSPPTSPTPDASGNPGHDALASLLSSLCPTTRVIVLGYSDGAQIAGDLATRIGHGEGPVPASRVLAVGLLGDPRRGSSTPQLGEPAGGQGVEGPRAQDFGELHDRVRTVCARDDLYCSASPDTDPVLTALGRAVSGTDTTPTTTPSTLVFPSTTPEPTTSWPTSPDSNPTAPGAIGGLDPSQIIEQVATVLSGLAEFAANLPAIGNDLVQLPGLIVTGNIPALHQVSGDLNNQFAPLVQAVAEVDLHLVARALTLAAPLDTSGWTAIAAQIVSILANLDIARLATDIGQAQEIAWDAVQKLTTGDPAGAAVAVTGLGPIAADLVTTAASTLTGDGGTRLSTLAHTLTTTTTPDTRNALANLTSGIHQNGYTDTTVGPVLNWLSGRTGTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Z1</accession>
    <name>A0A231H0Z1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778072.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42461">
        <property type="protein sequence ID" value="OXR42461"/>
        <property type="gene ID" value="B7C42_05237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="27790" checksum="1BEA6A9457A4364F" modified="2017-10-25" version="1">MTDVAQTVLRAYGGERWTELTSITAHKRFGGALWDIKQVPGIVDDGEVTVWIQDQRTSLRPFTAPDRRSVYTPDRVAIETLDGQVVAALDRPRASFEGHTLGTPWTPVQLAYFTGYAMWTYTAEPFNLTLPGVRIEEGEPWSEDGQRWRRLHVDYPATIATHSAHQVLYLDRDGLIRRRDYQVDIAGGSPAAHYVSDFDEVDGVVVPRTRMIYVRDADNRPIPEQLVVSIELTDITLDRANGKGIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H180</accession>
    <name>A0A231H180_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42614">
        <property type="protein sequence ID" value="OXR42614"/>
        <property type="gene ID" value="B7C42_05392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22487" checksum="53D77CE0B14C3022" modified="2017-10-25" version="1">MCSVVLIACGCVGAVERDAFEQQIRARGGGFVDGLPAAAFEALRNRLGTGDIQADVVMFVAPESTQFRLVLADQPEQVTRFLADHDDLSTREPAVHLRVRTAQRPHELDDYSYRLGAVSAPRPVRVSAFDDLDSECFTLAEVPGLTRLGSIVDTARARSALADGVVPVIVVSRFGRDIRIVADVTSPRSDMIAEFDSAGSFLRIRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1L6</accession>
    <name>A0A231H1L6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42743">
        <property type="protein sequence ID" value="OXR42743"/>
        <property type="gene ID" value="B7C42_05080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="14665" checksum="B011408BA2EE98C4" modified="2017-10-25" version="1">MRLPDSAREFIGAGANATLVTLNADGSPQVSVVWVALQSTPEGDELVSAHLGEYLKVRNVRRDPRVALTIVSDQPSGFMRPYLSVTGTARIVEGGAPELLKELAAVLAAPGLNFPPADAPPGVLTRVRIDKIGGVGPWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1M0</accession>
    <name>A0A231H1M0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_05075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42738">
        <property type="protein sequence ID" value="OXR42738"/>
        <property type="gene ID" value="B7C42_05075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="25145" checksum="0D8CD74616CC03A5" modified="2017-10-25" version="1">MPESRTGPSATASPRPNLAQRRKSATRMEIAHTAARLFAERGTAAVTAEQIAAASGVGLRTFYRYCRTKEDAVEPMLSAGASRWLDILGDGPDRLPTIAELETAAIRALTVVDRDELDITRGLLRAMADDTALRAVWFRVNLTGEHALLGLLAKLSPDTDPLRLRTLAAAAAGAIRIGLEQWADDDGASQIGVPDENLSAATETALRPGGPAPLVVRCMRELTAGVYAQAPADPAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1U2</accession>
    <name>A0A231H1U2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42813">
        <property type="protein sequence ID" value="OXR42813"/>
        <property type="gene ID" value="B7C42_05151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12113" checksum="0222DEBC59F9DCF5" modified="2017-10-25" version="1">MSQYLILIYQDERAVAEPESGSAMFDSHRQFGEAHAAALRGGNALHHSHTATSVRPDGAGDFVITDGPFAETKEQLGGYYLIEAEDLDAAIAIARRVPMSSGGVEVRPVLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2T1</accession>
    <name>A0A231H2T1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase 2</fullName>
            <ecNumber evidence="3">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB_4</name>
        <name evidence="3" type="ORF">B7C42_04595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43173">
        <property type="protein sequence ID" value="OXR43173"/>
        <property type="gene ID" value="B7C42_04595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="31665" checksum="6EB07856E9042B62" modified="2017-10-25" version="1">MSMATRTVDPVSLADVLSIHRIGGSEFLGPARPTAAPRIFGGVTAGQAILAARATVTDDRPIHALQTTFLRPGYGNSPVTYRVEPLHDGTSLTTRLVTATQHDRIIFTATASFQQPENGLAHQLTTLSAPDPEDVEPAAQIVGEGADRAWLSALEQTTMLEFRFPDTPVRVSAGQGTAVEPYQRFWVRPPQPLPDDDVVHAAVLGYLSDALLLSTSLGPHRRTVHDPDLRFATINHSIWFHSPGPADEWLWYEQEGIWAGSARALCRGSIFRRGGELAATIVQEGLIRIAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3K1</accession>
    <name>A0A231H3K1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43411">
        <property type="protein sequence ID" value="OXR43411"/>
        <property type="gene ID" value="B7C42_04278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="9073" checksum="B8F00A5D051BFBF3" modified="2017-10-25" version="1">MSVDYTGYDDPVTPEPDDRPGRERIVDLARGGRCGAAGCRERGYRPYATHRPTHAAPPGSGGMTSRKIFWHNIIGEIGRHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H464</accession>
    <name>A0A231H464_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-hydroxyphenylacetate 3-hydroxylase, reductase component</fullName>
            <ecNumber evidence="3">1.5.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.36" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43655">
        <property type="protein sequence ID" value="OXR43655"/>
        <property type="gene ID" value="B7C42_04523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036382">
        <property type="term" value="F:flavin reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22880" checksum="EBF4303A3C30046C" modified="2017-10-25" version="1">MTLSPTKSIPRQTDPRLLRRVLGEFSTGVTVVTYRDSDGNTRGATMNSFTSVSMDPPLLLVSVSRKARAAEGLKDTAFTVNILSANQLDIALHFAGKPNEALVVPWHDVPGMPPRLLGTTAWLQCEPWQIYDGGDHLLVLGRVVHHDARTLEPLTFHRGEFRRLGLKMLQMPRTVTFDGRPACEWAQRLQNLHALAEGGVGPEPLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4M3</accession>
    <name>A0A231H4M3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781173.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43805">
        <property type="protein sequence ID" value="OXR43805"/>
        <property type="gene ID" value="B7C42_04040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="114" mass="12172" checksum="D925B14F2E1D48D8" modified="2017-10-25" version="1">MNPDVTAYIDGKKAWQSGICANLRRTVHSTLPGVAEVFQYGKPHFTVDGTNVAVLHVAAAKVSFMVFGAQEIEPVPGVLRSLGSGERKAVDFREGDAVDSGFIADLLRRVAGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H523</accession>
    <name>A0A231H523_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">menA_2</name>
        <name evidence="6" type="synonym">menA</name>
        <name evidence="8" type="ORF">B7C42_04061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43826">
        <property type="protein sequence ID" value="OXR43826"/>
        <property type="gene ID" value="B7C42_04061"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601738" description="1,4-dihydroxy-2-naphthoate octaprenyltransferase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="32255" checksum="0DACDFFB897199C3" modified="2017-10-25" version="1">MVKPSVVTLRCRLRATTIRLPDMASAAQWLEGARPRTLPNAIAPVLVGTGAAASLDAAVWWKALLSLLVSLALIIGVNYANDYSDGIRGTDDERVGPLRLVGSGLASPAAVRGAAIACLSVGAVFGLILVITTAWWLLLIGAACLAGAWFYTGGSKPYGYSGFGEIAVFVFFGLVAVLGTEFVQAERLDWAGLVGAIAVGAFSSAVLVTNNLRDIPTDSVTGKTTLAVKLGDTRTRTLHLVLMVVPFAASLLLVMRTPWALVGLLAIPLAVRSNAPVRGGQQGPGLIPSLRDTGLAMLGWSLLTALALGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5B0</accession>
    <name>A0A231H5B0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nudC_1</name>
        <name evidence="3" type="ORF">B7C42_04211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776410.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43972">
        <property type="protein sequence ID" value="OXR43972"/>
        <property type="gene ID" value="B7C42_04211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="14721" checksum="E1BCB17EF8E662BF" modified="2017-10-25" version="1">MIRTAALAHIRNRRLLQTRSTGKEVFYMAGGKIDPGESPVQALYREVREELGVDVTAHDELGVFECEAYGHTPGTALHMTCFTADLTGEPTPTSEIAELRYFTVGEYAAMPHVAPGSMLVFRRLHELDLIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5C1</accession>
    <name>A0A231H5C1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lolD</name>
        <name evidence="6" type="ORF">B7C42_03610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44054">
        <property type="protein sequence ID" value="OXR44054"/>
        <property type="gene ID" value="B7C42_03610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="26"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="25700" checksum="D6A3819C87924D6E" modified="2017-10-25" version="1">MSLFATRRTDATQGDPRDLDDTKTGLDLDGVALTLGDGADTVTALDDIHLSVAPGEFVAIIGPSGSGKSSLLAVAGGLTTPHAGRVRIGGTDLTALGARARTRFRLRHIGFVFQSGNLLPALTAADQLRLIARLTGARRDPRELLDAVGMGAKANRRPEQLSGGERQRVGIARALIGSPRVLLVDEPTSALDRARSAEVVELLARETRAAAVATVMVTHDHDILDRCDRVLHMIDGRLTPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5L5</accession>
    <name>A0A231H5L5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mraY_2</name>
        <name evidence="7" type="synonym">mraY</name>
        <name evidence="8" type="ORF">B7C42_03686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500353.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44128">
        <property type="protein sequence ID" value="OXR44128"/>
        <property type="gene ID" value="B7C42_03686"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="38128" checksum="3DAB81D087BA470E" modified="2017-10-25" version="1">MRQILFAAGIALAVSILLTPLLIRMFARRGFGQEIRIDGPESHQAKRGTPTMGGVAILIGMWAGYLGSHLIGIGYHADGPSASGLLVLGLATALGVVGFIDDFIKLRKQRNLGLTAAGKYIGQLGSAVIFGVLALQFRGAGGRTPASRHLSYVREINTVSMSVIIFLAFVCLVVVAWSNAVNLTDGLDGLAAGSMSLVLGAYVIITFWQYYHACEFKAEAGCYNVRDPLDLALVCAAGAAACVGFLWWNAAPAKIFMGDTGSLALGGLLAGLSITTRTELLMVVIGALFVAETVSVVLQVAVFRTTRNRLFKMAPFHHHFELSKWAETTVIIRFWLLAGIAAAVGLGLFYSEYLSQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5L7</accession>
    <name>A0A231H5L7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative type I restriction enzymeP M protein</fullName>
            <ecNumber evidence="4">2.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44006">
        <property type="protein sequence ID" value="OXR44006"/>
        <property type="gene ID" value="B7C42_03562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="131"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="659" mass="70725" checksum="54E8A239A8AD659F" modified="2017-10-25" version="1">MPKPVSKVSAAEISRLAGVTRATVSNWRRRHDDFPDPIAGNETRPLFDLHAVRKWLAEHNIEAAQSPDAELRTLVRSRATPDAITRVMQTLRREGDEWSAPGADDPELAAEIASALQLAETADGIRTALDILSERAMDDAASTGVYVTPVAVASTMAALTRSATTPNVHSVFDPACGSGSLLLAAAHEGARELYGQDVVPVQAERARLLIEAETTVEPEVRAGDSLTSDAFSGVRVDAVLCNPPYGLRDWGSGELAFDTRWDYGLPPRGEPELAWVQHAIAHLRPGGIAVLLLPPSVATRAAGRKIRSNLVRTGALRAVIGLAPGVAQPRHVGLQIWVVRRPEPDVAVPDSMLFIDTTGVAVRTDGDRADRDTVVEMWRTFDSEKPDSAAESGISAVVRLVDLLDDEVDLTPARYVRSALDSSAISEQVATSLDELSRAASELDTAVTTVPAWSESTGKSWRFVTVAHLATHGQLQWFRAAPQGTESPVGDRRRVLTALDVATGNRASGTVDMVPADPVEVHEGDVLMPAVRGDRRGGRSARVATSEDAGAVLGPHVHALRVDRDRLDPWFLAGFLTGAENISATRTSTVRFDASRLRIPVLSLDEQRRYGTLFRQLFLLRSAARRASDAAEEAAELITTGLTAAALEPGTGLGQGRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5R1</accession>
    <name>A0A231H5R1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">bioD</name>
        <name evidence="6" type="ORF">B7C42_03735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44175">
        <property type="protein sequence ID" value="OXR44175"/>
        <property type="gene ID" value="B7C42_03735"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="167"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="23180" checksum="B7F3A73FB95499DC" modified="2017-10-25" version="1">MSRLIVTGTSTDVGKTVVTAALAAAARSAGRSVAVCKPAQTGVAPGEAGDLAVIERLAGVTRTLELARYPEPLAPDTAARRCGQPLLTLGETVAGIDSLADADLTLIEGAGGLLVRVGEFTLLDLALKLDAPVLVVAAAGLGTLNHSELTTRTLAASGVRCAGLVIGSWPSAPDLASECNRTDLPDVTGVEVVGVIPEGAGQWLPERFADTASGWFHADWMRRYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6B7</accession>
    <name>A0A231H6B7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--AMP ligase FadD29</fullName>
            <ecNumber evidence="2">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44332">
        <property type="protein sequence ID" value="OXR44332"/>
        <property type="gene ID" value="B7C42_03893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="573" mass="61641" checksum="ADE7038DD012EC52" modified="2017-10-25" version="1">MRSLVDWITERDNDGTVRFYTGHQWESLGYDSMATEALNVAGALRERGIGRGDRVALVLPTCPEFPRYFFGVMAIGAIPTVVAPIGLPEGGRAGHLSRLRALAPAAVVAGAETLAGLAEAGPDRPRHLIDADEPIPAADRVALCPATDDETAIIQFTSGSSSLPRAVRISARAAIAHVEMLKSVFHDSTGQSTQTFGSWLPLHHDMGLIGTFLSPILYAQDAWLMRPEHFVRRPLTWLELFGRHGANHSAIPNFAIERIVRLVGATALAGMDFSEWRSLIVGSDRINFAALRSFYELLAPFGLPARTVKPGYGMAETTLAVSVCPLPDVPTALDIDHRTLSDQAQVEVLGQRDLLDTEPVPDGATCIVSCGRALPGAHIEVVDSDRVVLPDGQVGEITVASPALFSGYLDEDDTVPVVHYTGDLGFRYQDEVYVLGRMGNAIKVNGTFITAEDVELALAERLRVHHDKITVVLRDLEMAGKPSSLVVFQQRVPTEAVETTLSVLRRSGLDAATAALVTMAPLAIPRTTSGKPRRVELWNDLATGISAARQLFVGAASPLLRLTLGAGHEPPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6C3</accession>
    <name>A0A231H6C3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44389">
        <property type="protein sequence ID" value="OXR44389"/>
        <property type="gene ID" value="B7C42_03178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="16805" checksum="DCB450E54355554C" modified="2017-10-25" version="1">MNSVDIARELPGERSVPRTGWRSQGGPLLAAGAVVAAAAVLHFHDPHSQGAYGICPFYALTGWWCPGCGGLRAVHNLTEGRVLDALHSNVFVLPLLLTLALWWGRWALGRWRGRADTAFPFTLRGQAQWWLIGLLALFTVVRNTPWGTWLAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6F2</accession>
    <name>A0A231H6F2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xerD_1</name>
        <name evidence="7" type="ORF">B7C42_03159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44370">
        <property type="protein sequence ID" value="OXR44370"/>
        <property type="gene ID" value="B7C42_03159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="236"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="429" mass="46796" checksum="DEDB08555EDD86F2" modified="2017-10-25" version="1">MSTPENISRKPRRKPGNVRIEDRHYIDGDRSRPTSRWKTDANGKRVPIGKRYIVHWNDPTGTPKSKSFDKRGQAEDHKTKMVTEIHEGTYRDPHKVGTPFSVIADLWVKSLASAPKSTASAHKSVLKNHVRPTFDPREIGSITKTDIVSWVAELTDKGLSPATVHRCFVALRGVLTLAIPDHLRADPSAGVKLPPLPSAKDRFLTHTEVALLAAAADYRAGTKRPGARTDVKGETGGPLPVDKKGVPIVPAADPSPDGLAIRFLAYTGLRVGELSGLQVSDVDLKKGRVRVDGSLAVDEDEPGDTKSRKTRWVPIPKSMHAELRKHLKGRKADDWAFTAPGGGPIRRTNWNRRVLKPAAELVGLLPLTAHDLRHTYASLSASSGVRVEVVSKLMGHADPGFTMRRYIGLFPDDMSASADLLDAAMSAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6K7</accession>
    <name>A0A231H6K7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44485">
        <property type="protein sequence ID" value="OXR44485"/>
        <property type="gene ID" value="B7C42_03274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="173" mass="19905" checksum="746D9BE976B4F28E" modified="2017-10-25" version="1">MLLRPNTEPDLWSNLFRELTRSAFHLEVRDEYHVPDEESRVRAFLAGEPAPYSHTPWQDLMRETTARGVTVSRVRVVTEPHSDYQRWLLSVTGSNIDAGEDIRYVPRHIAGQVPPDDWWLMDAQRVVYNLTDSAGAPAGGLAVTTDPEIVEYCLRVRERLWKLAIPYAEYAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6M7</accession>
    <name>A0A231H6M7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775887.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44505">
        <property type="protein sequence ID" value="OXR44505"/>
        <property type="gene ID" value="B7C42_03294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="14591" checksum="AEAB027A61C3F6D1" modified="2017-10-25" version="1">MDELADRFFAAVSAGDTAALTALYAPDARIWHNDKNAEETVTENLRVLRWLSRTVEDLRYEDIRRYVLPDGFAQQHVVRGHLPGHGELEVPASLFVRVRDGHITRIEEYVDSAATQPLREVSATNGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H714</accession>
    <name>A0A231H714_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="10">1.4.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pdxH</name>
        <name evidence="10" type="ORF">B7C42_03465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44671">
        <property type="protein sequence ID" value="OXR44671"/>
        <property type="gene ID" value="B7C42_03465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="8">
        <location>
            <begin position="75"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="9">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="28096" checksum="C44ED1FBD9BE7A8C" modified="2017-10-25" version="1">MREEQNSPGSAGGESGLPTANSSTLPDRFGAVPRVDVDIAAMRAEYGGDPDLTESWPAEGWEPLLRNWIELATNAGITEPNAMVLATVELTDAGPRPASRTVLCKGVSAEGVTFYTNYDSAKGDQLHAVPYASATFAWPKVGRQVTLRGPVDQVSTEVTTAYWRSRPRNSQLGAWASHQSRTVASREDLDRALADVTARFDGVEQIPVPANWGGYILRPEQIEFWQGRRSRLHNRIRMTLPDGPTAIGSARIERLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7S3</accession>
    <name>A0A231H7S3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44984">
        <property type="protein sequence ID" value="OXR44984"/>
        <property type="gene ID" value="B7C42_02941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="236"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="35187" checksum="D7468AAE08CF558D" modified="2017-10-25" version="1">MTESVSLPRVTDAPLLNAAVSRLEKVLEALLNGLGDGNAKKVVMASLAATDKPTATITGEMVADYGDRQKKIRKYNEEWNSLDTMMSDIAENSAGIANETRAAVKQLETDITGILSGVAPHPSVALQLSLIDKIDKAVEHADLVVSQAHKLHDENSTRIPTQPQGSGGGGDYGPVPSTYVPPNSSGSYDRQYTQPVSSSGGGPGRHLDDQELAYYIGKALDRLGITDPAARARWTEGYLTLIKRESSGNTGSINTTDSNAAAGHPSQGLTQTIPSTFEAYHVAGTSSDITDPEANIAASMNYVMDRYHVSRDGSNLTSNVQQADAGRPAKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7S6</accession>
    <name>A0A231H7S6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784191.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44931">
        <property type="protein sequence ID" value="OXR44931"/>
        <property type="gene ID" value="B7C42_02888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17690" checksum="51B673E2F34B9EBF" modified="2017-10-25" version="1">MSTIHLTHTTTSTPEQFVAALTDFGPGRSKLFGNSTDEYLHVHSQDATHADVTEGSHRIWERLRYDWSDPHHVVMTTTDSNMWGGASGHTYTLTPMPDGTTEVDAVVVREGKNLTGHLLEAVIGTVGKRVLDKELVKTIHAVEARNAGGPSTDPAAGPHDMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7V3</accession>
    <name>A0A231H7V3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515621.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45093">
        <property type="protein sequence ID" value="OXR45093"/>
        <property type="gene ID" value="B7C42_03050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="11944" checksum="550EB6FB4DE5CD77" modified="2017-10-25" version="1">MPKEWSAKEERQYEHVKSSARKRGASKGRAEEIGARTVNKNRAQAGKTRTASRSSTNDMSPQRRGGQRSGKGSQGPTRDQLYNEARQRNIKGRSKMTKKQLASALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8D3</accession>
    <name>A0A231H8D3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 3-oxopropanoate dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bauC_2</name>
        <name evidence="4" type="ORF">B7C42_02329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45204">
        <property type="protein sequence ID" value="OXR45204"/>
        <property type="gene ID" value="B7C42_02329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="22"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="506" mass="53780" checksum="A389655C19902791" modified="2017-10-25" version="1">MVRELTHFIAGTHVAGTSGNFGDVYDPSTGQVQARVPLASVSEVEAAIANAAEAQRAWAAFNPQKRARVLMKFVALVQGELDSLAALLSSEHGKTIPDAKGDIQRGLEVIEFAIGIPHLLKGEYTESAGTGIDVYSMRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPLRLAELFLEAGLPAGVFNVVNGDKLAVDTLLNDERIKAVGFVGSTPIAQYIYETATANGKRAQCFGGAKNHAIVMPDADLDDVADQLIGAGYGSAGERCMAISVAVPVGEETADRLRAKLVERIGKLNVGRSDDPGADFGPLVGRDGVDRVNNYVQIGVDEGAELVVDGRGLKVAGAEDGFFVGATLFDRVTPQMRIYREEIFGPVVAIVRAADYEEALRLPSEHEFGNGVAIFTRDGDTARDFAARVQVGMVGVNVPIPVPIAYHTFGGWKASGFGDLNQHGPDSIRFYTKTKTVTQRWPQGLRTAPAADAGADHFVIPTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8R6</accession>
    <name>A0A231H8R6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782376.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45192">
        <property type="protein sequence ID" value="OXR45192"/>
        <property type="gene ID" value="B7C42_02317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011309515" evidence="1">
        <location>
            <begin position="30"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="13582" checksum="671CE78897DD1603" modified="2017-10-25" version="1">MRRILFAMTLCAAVLPTLACSAEADRAPAKTSAPASAPAAADHGTDGTIEVVATHGPEKYAAAGLAAGISPCQAGSVLATLTTGRDGKAHQDVAADCYQVQVTSVPMGCRLATDPARKVDVVAGRTATAEFGLACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8V1</accession>
    <name>A0A231H8V1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UMP pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="11" type="ORF">B7C42_02420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45295">
        <property type="protein sequence ID" value="OXR45295"/>
        <property type="gene ID" value="B7C42_02420"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR45295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="21997" checksum="F57DAE4B9EF007F9" modified="2017-10-25" version="1">MRTHIVEHPLTATLLTAMRDARTSNAGFRAALADLTGFLVYEALREAPTDTFDIDTPVAPTRGARLAKPPLLVPVLRAGLGMVDAASALIPESRVGFVGVARDEQTHRPVPYMESLPADLSGLPVFVLDPMLATGGSMRHTLELLCARNATDITAVCVVAAPEGIAALEKSDLPVRLVTAAVDSGLNADAFIVPGLGDAGDRQFGPRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H914</accession>
    <name>A0A231H914_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rbn_1</name>
        <name evidence="8" type="synonym">rnz</name>
        <name evidence="11" type="ORF">B7C42_02417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45292">
        <property type="protein sequence ID" value="OXR45292"/>
        <property type="gene ID" value="B7C42_02417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="10">
        <location>
            <begin position="194"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR45292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="32989" checksum="99DDA1ECC0CEF016" modified="2017-10-25" version="1">MRELVVLGTASQVPTRRRNHNGYLLRWDGDGLLFDPGEGTQRQMLFAGVSASGITRIGLTHFHGDHCLGLPGVLARLNLDQVTHPVDICFPGSGAELLTHLRGVVPEFPGLREHPIDADGPVPLPDAPFTFEAVRLSHRIDTFGYRLVEPDSYRILPERLAEFGLAGPMVGMLQREGAVRLPDGRTVTVDEVSVPRPGQRFAFVMDTRMCSGIAELAEGADMLVIESTFLEAEAQLADDFGHLTAGQAARVAAAAGVRTLVLTHFSQRYGDLAGHRAEAQRYFDGELVIAEDLMRVPLPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H918</accession>
    <name>A0A231H918_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS-type transporter EfpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efpA_3</name>
        <name evidence="7" type="ORF">B7C42_02312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45187">
        <property type="protein sequence ID" value="OXR45187"/>
        <property type="gene ID" value="B7C42_02312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="479" mass="49630" checksum="CA366AB5843F8AF9" modified="2017-10-25" version="1">MTTSTTTSTFSSSTQVGAPPGRLRSGIVLVTLLTCQLMIVLDITVMNVALPRIQHDLHFSATGLSWVMNAYTLVFGGLLLLGGRAGDLFGRRRMFILGTVLFTLASLGGGLAPSAAWLIVARIVQGLGGAMAGPNTLALLTTTFADPKMRVRVLALFSGMSSAGFAIGLILGGLLTQWLSWRSVLFINVPFGLAVALLAARYLPDAPRRRAHLDLPGAVTATGAVAALVYGFISAAAHGWGDVTTDVSLAAGVLALAAFLLIERRAVQPLLPLHLFADRNRAAAYANMFLGPMAGTSMFFFLTQYLQEVRGMSALATGFAFLPTAVTMFAMIRLIPRLLPRFGPKPVTLVGTSAMIAGLALLTLLDTDTGYFPLLAVAMVAMGCGIGLAFSPLNVIIMANVAPEEAGAAGGALQTLQQTGAALGLAVLVTVFGTAVRAASGSAVHVLVSGITTAFAAAAGIAVLTLLVASTFRSVRAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H997</accession>
    <name>A0A231H997_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45401">
        <property type="protein sequence ID" value="OXR45401"/>
        <property type="gene ID" value="B7C42_02526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003540">
        <property type="entry name" value="ADP-ribosyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03496">
        <property type="entry name" value="ADPrib_exo_Tox"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADPrib_exo_Tox" evidence="2">
        <location>
            <begin position="144"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ADPrib_exo_Tox" evidence="2">
        <location>
            <begin position="530"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1053" mass="115005" checksum="79CB10DD42AA5044" modified="2017-10-25" version="1">MRRFGSDEAGQRYGDNRLAHVLDSLPPELQHAVRQYTVQSFPNGFLRSPNPLEAVGRHFDHLRAESHAAAALTHANRGEMPRTVADLDRMTMRRDLDPFQRQWVDFVRSQPDPVARLDALASNQGNWRFLHQYFDGPPTVEAFHRRIAETDAALNRPLPESVQVLRGLHDLSFMETEMGRQLGAGGDPRALIGTTQTERAYMSTSLGANLTQVDGRPFPFRIEMTVPAGSPGLWMGHDSAYPDQRELILQRHTRYRINDVVHTGWVQTESGMRPTFTVHAEVLPPEHMAAPAAEHERPSAPASRTASTASGPHRNEPSGPAPHEPARRPSDAQPAPSTRRSDSENSNPAHTPPRNDGNPGPTAHPAGVPARGETMRPSERPSPGAPAAAPNGRPPATPVTTANGPRPDHPAPNEERRPGPGSSAPREPGPAVHRPSEPTTTTTSVDRSSPPPHRSGPEPVAPTRTDGARPDVRRPEPTHPTPEPSSPNETRGNRDIPEPGRRDSAPAHTSPERGDAVAPHHRDAPDHAHGEPTPEQHRAIRDYTDPDGNHYTDLNNRLRNHTELDPAQEQLAQRISDGLSNLPAHTGTVWRGTSLSPEEIARYVPGETVTEAAFTSTSRDPRRTFVGNVEFVIHSSTGRDISAHSVRPGEREVLFDRNTTFEVRGVTHDPTAGLFGRSRIYLYETPSHVPRSEDTVEHHGPDDHAGPIDHEIGTGTDEVEHSVLHGTDRTAIGDDPQTHRVYDNLRNEGEHDVIVHGNRFGRPIPGHENEASPQHVAEAIRNNPNYQPGTPVRLISCHAGNDIGWAQQLADELGAPVRAPSDTVGVRQAPDSPAVVHDGGHWVTFHPGGIEPPPEPHHHVDVAESDGSAVTTEGRRDGWDIMASDENHLEAAVDPSVDISDMGVDPRWRTDNEPLYRSDNRPPAVIFDEGFSPRDPSFTDLSQYVEDDVPSAFVSTSTREDIGEEFGGRFTYELDAPGGIDVNETLGAHTMEYESEVAFPGGIRGEFIVGARSYSYSTGEYGDFIPNPNYVTRDDGDPGAGGRPSDSDESTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9B9</accession>
    <name>A0A231H9B9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpS</name>
        <name evidence="10" type="ORF">B7C42_02451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776663.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45326">
        <property type="protein sequence ID" value="OXR45326"/>
        <property type="gene ID" value="B7C42_02451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="37677" checksum="0418F73A6E06C327" modified="2017-10-25" version="1">MSSPAPSERKQRVLSGVQPTSDSFHLGNYLGALQYWVPLQDDYEALYFIPDMHAITVSQDPKQLRSRTLHSVAQLLAIGIDPKRSTLFVQSQVPEHAELTWVLSCITGFGEASRMTQFKDKSAKQGSDNATVGLFTYPILMAADILLYRPQLVPVGEDQRQHLELTRNLAQRFNTRFKKTFVVPEPHIVTGTAKIYDLQDPTSKMSKSAASDAGLISLLDDPKVSAKKIRSAVTDTEREIRYDPETKPGVSNLLVILSSLTDTPIVTLEKGFEGKGYGELKADVADAVVEFVTPLQAKVQEYLDDQGELDRILATGAEQAREIAGKTLAQVYDRVGFLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9T5</accession>
    <name>A0A231H9T5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neutral endopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pepO_2</name>
        <name evidence="11" type="ORF">B7C42_02631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45506">
        <property type="protein sequence ID" value="OXR45506"/>
        <property type="gene ID" value="B7C42_02631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511450" evidence="8">
        <location>
            <begin position="37"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13_N" evidence="10">
        <location>
            <begin position="55"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="9">
        <location>
            <begin position="478"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR45506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="680" mass="75491" checksum="88A7284EFC1D5B2C" modified="2017-10-25" version="1">MTSSGRQVRLGRRSFLIALGAVPVATALVACNSDDAKPKPLTGPDLSGVDPAVRPQDDLYRNINGTWLRTYQLPPDKVSYGTFAEVSDRVEGQLREVIDGIHDPKDGSEGQQIRDLYDARMDLDTLEKLGTAPLQPLFARIDGAQNRADLAKVMGALPLGGLIGLGVSIDRKNSNAYIPAVGQSGLGMSEQYYRKPEFGQYLSAYQTLLHKLATGAGLPDPDGAAERTLDLEKRIAAGYWDNVRTRDADATYNLMAWNEMTALAPGFDWEPWLAGSTDRPKDLFTKMVVGEPSFVTAAGQLWTEVDINVWREWLKLSLLRKYAKYMNKELSDANFDFLKATSGIEQRPELWKSAVAVVDANLGEQLGKLYAAKYFPPQAKTRAKELVDNLLAAYRDNFRNSSWMSPRTREAAIAKLDKITVKIGYPDKWVDYSKLKVTRGQLVESLLAIEAFEAKRSMDKLGTPVDKAEWGMSPQTVNAYYEATSNSINFPAAILQAPFFDTDAEPAVNYGAIGATIGHEIGHGFDDQGSKYNGEGNREDWWTPEDRAAFDAKTKQLIDQYNALVPEGLPPSDHVNGQLTVGENLADLRGLMIALAAFRIEEAKSGRNAPDYTPMFQSWGRNWREKQTQQSLEQQVATDPHSPGEFRCNQVVRNLPEFYTTFGVQPSDKLFLPEDQRVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA57</accession>
    <name>A0A231HA57_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783993.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45617">
        <property type="protein sequence ID" value="OXR45617"/>
        <property type="gene ID" value="B7C42_01909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="99"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="44330" checksum="BEE78B7633CB8D26" modified="2017-10-25" version="1">MKLLAHDVDAHEMIPSHLLEDVLGKPGRIMGKIFESADKLRPDPSDTNMHQPNIEGDVKDVDPEGIWKIKGPSAPSAIDLSRRVEVLDVMGIDKQLVFPTTAIAAMMIGEMEDIAYDMRFGGDLSVFEGLSRPEFAADYVRSYNEWVKANANLADGRIRVVGILTTNSDPAKMLAMAKDLVDAGVKAVYLQADVPPGGVAPSHSVHDPLWKLLEENNIAVTLHIGTEFAFLNPGWMIAETLQDLFQSPEIPNTNIQLFSTVHFAIENYLSSMVLGGVFERFPNLRVGLFEVGADWVGNSARRMDMYVKVFPGASAAKFSLKPSQFIARNVRVSPFNFEPADRYFREDPELADVFCYSTDYPHVEGTKDSMKNMLAKIEPLGEEITTKFFRTNAEWLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAD1</accession>
    <name>A0A231HAD1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-[(3aS,4S,7aS)-7a-methyl-1, 5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD3_2</name>
        <name evidence="3" type="ORF">B7C42_02112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45820">
        <property type="protein sequence ID" value="OXR45820"/>
        <property type="gene ID" value="B7C42_02112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="18126" checksum="85FD18F4C406A1CC" modified="2017-10-25" version="1">MAVGETGVVYFEGGRPFDYHNDPERTAAATGPNGWRTLGDIGRLDEDGFLYLTDRLSHMIVSGGVNIYPQEAENVLAAHPAVLDVAVIGVPDPEMGEAVKAVVQPVDSASAGPALAAELIARCHAELAGYKCPRTVDFTTELPRDPNGKLYKRPLRQQYWDGHAGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAR7</accession>
    <name>A0A231HAR7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(S)-phenoxypropionate/alpha-ketoglutarate-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sdpA_2</name>
        <name evidence="5" type="ORF">B7C42_02128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.43" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45836">
        <property type="protein sequence ID" value="OXR45836"/>
        <property type="gene ID" value="B7C42_02128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="30053" checksum="BBC623E33E115923" modified="2017-10-25" version="1">MVETTALNPTIGVEVTGVEDLHDDTVISRCTEALKWRGVLVVRGLHLDDEAQLAFCRRLGTVLAPGGREIFTITLNPEKNRAAKYLEGTFFWHIDDTTNDVPAKATVLTARHVAMEGGGTQFASTYAAYEGLSEAERTRYDSLRVVHSFEASQRLVHPDPTPEQVADWRQLPTHETSLVWQRRDGRRSLVIGATADHIVGMDPVESRKLLDELLEWSTQPRFAYTHDWSVGDLVVWDNTGILHRALPYDATSERELHRTTIAGAEPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAS6</accession>
    <name>A0A231HAS6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45922">
        <property type="protein sequence ID" value="OXR45922"/>
        <property type="gene ID" value="B7C42_02215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="70"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="277"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="399" mass="42842" checksum="19B3DEAC5D27CCB8" modified="2017-10-25" version="1">METEAKAGSLVTSTDDVSAGSAVKQAEAASGTLERDVATLEKAIYEVKRVIVGQDRLVERLLVGVLARGHVLLEGVPGIAKTLAVETFAKVVGGSFSRVQFTPDLVPTDLIGTRIYRQGREEFDTELGPVVANFVLADEINRAPAKVQSALLEVMAERHVSIGGKTYPMPDPFLVMATQNPIESEGVYPLPEAQRDRFLFKVVVDYPTVEEEREIIYRMGVTPPEPKRILEPAELIRLQKLAANTFVHHALVDYVVRVIAATRKPAEFGLDDVAGWIAYGASPRASLGIIAAARAVALIRGRDYVVPQDVVEVVPDVLRHRLVLSYDALADEVSPDDVIRRVLQTVGLPQVATQANAPAQGGPAPMPAPGPQAAAPQPVAPHPAGQPQNGQGAGQPQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAT3</accession>
    <name>A0A231HAT3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">agaA</name>
        <name evidence="8" type="ORF">B7C42_02238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45945">
        <property type="protein sequence ID" value="OXR45945"/>
        <property type="gene ID" value="B7C42_02238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353201" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Melibiase_C" evidence="7">
        <location>
            <begin position="388"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="465" mass="49755" checksum="B01A3ED4D62703D0" modified="2017-10-25" version="1">MRRARAIRLAVLGAGVVAVAAAVTGSMVRPPVFEPAPVRATAPMGWNSWDSGITLTEQSVRETIDAMVSDGMRDAGYRYVDLDAGWAAPQRDSSGDLVADPVRFPHGMAAVAAYAHEHGMSLGLYSSPFNEICGQSPATASRGHELQDARRFAGWGVDLLKYDWCRTDANHDEQVRDFARMRDALRSTGRGIVYMINPNSSADARAGVDYDWSAVADSARSSDDLIPMWRNIFPEPDIGGFDTTSVRGVADEADAALRARPSRPGYWPDPDMLVVGQSMSQFLGAHLDGLPGTAVRRSALSADETAYLARRLGISPETLALLRNPRTLSPAEEQAHLSLWAMLSAPLIAGNDVRTMSDSTRALLTDAGVIAIDQDPRVAPAVPLSRDRRILTKPLSDGSVAVTLLNPGDQPLTLTTSATEAGLAQAQSYTVHDIWAATTTVTDGRIVAPDIPAHGVVLLRITPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC37</accession>
    <name>A0A231HC37_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">recF_1</name>
        <name evidence="7" type="synonym">recF</name>
        <name evidence="11" type="ORF">B7C42_01417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46451">
        <property type="protein sequence ID" value="OXR46451"/>
        <property type="gene ID" value="B7C42_01417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="411" mass="44810" checksum="0D9CEC81C946A59A" modified="2017-10-25" version="1">MHIRTLTLRDFRSWEHADLELPTGRTVFLGSNGNGKTNLVEAVGYLSTLGSHRVAGDAPLIRLGQQRSRIGATVVNGGRELRIDVELNQGSANRAQINRSPVRRTREILGILQTVLFAPEDLALVRGDPSERRRFLDELATARLPRLAAVRSDYDRVLRQRSALLKTAGRQARSRSGAPAELSTLDVWDGHLAAHGAELLAQRLRLVHELHPYLEQAYRSIASESRTAAIRYRSSALPEDFLDPQRSPQPGDVEALEANMLSELASARGKELERGVCLVGPHRDDLDLMLGSAPAKGFASHGESWSFALALRLGAFELLRSAGTDPVLLLDDVFAELDRRRRTALAAVAAGAEQVLITAAVPEDVPPELGANPVRVETDGVADGRTSRIVEPPPRTDEPRAGESIEGRHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD13</accession>
    <name>A0A231HD13_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46692">
        <property type="protein sequence ID" value="OXR46692"/>
        <property type="gene ID" value="B7C42_01667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11983" checksum="E0A213062F2C47FD" modified="2017-10-25" version="1">MIYTPTYQQVLADAERIARERGDNYVCAEHLLLAYLGDPQFVGNIEMRDRMRTSDPAELAKRIGWFLDSPKPGPGEHSVRPLDGSVTIRRNDDLSTVTRWAPPEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDG9</accession>
    <name>A0A231HDG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_01766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46788">
        <property type="protein sequence ID" value="OXR46788"/>
        <property type="gene ID" value="B7C42_01766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="43795" checksum="A5F96F2B6C5F7503" modified="2017-10-25" version="1">MPKPPRYPPPHGIPPHGRPPYGPPPGYGPPPGYGPPPGYPPPGPRPPYGAPLPPPGVYPVGPYGGPPLPPPGYYGRPYPPQRSGGGAVGAVLAVLFVFVVVGGLVAFATMGGRDNSSASYSTSTPSFTYTPPTWATSTSETATTTRSTTTPYPSTTKPYYRTTTVVPTTKPAGPQPVAATAANPIFDDHNSGLINISCGYPRWGSDVASATAFFQAAKSCLDRMWQPVLAAQNLPFSSPTVSVPASGANAASPCGSSGSYAAFYCSANNTIYMPLDHIQTEVYGDRWYVYLGVFAHEYGHHVQAISGIMSKMSRDRYSAGTNSAAGLELSRRLELEAQCFGGMFISSSEVAGTVSNDQAYYVKQDNYQRGDDHSDVRDHGANQHYGAWYAQGEDNNRTWMCNTWNSPSDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI4</accession>
    <name>A0A231HDI4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_01765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46787">
        <property type="protein sequence ID" value="OXR46787"/>
        <property type="gene ID" value="B7C42_01765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011231013" evidence="6">
        <location>
            <begin position="28"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="30334" checksum="E4538C48642CF357" modified="2017-10-25" version="1">MGAVVVVILLIVTSGLIRFAVRTGFDAASHTGEHGNYSYNPPPGKDSAGVPETGANPLLADPGSPLSPARCPYTPWSTQVDAARAFFDSAAACLADAWKPVLENAKLSFTPPKLVVTATTSGITTPCSGSSSNFAAFYCGADQTIYMPISQLQTDMFHDHWEIYLSVFAHEYGHHIQALSGILGAANKQRRQTGLYSDEGLDLSRRIELQANCFDGMYFASSAGGKSLTPVQAQSARKDAYGRGDSAGDMRSHGTAEHAGDWWSTGFDKNATAPCNTFIAPSGQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDK4</accession>
    <name>A0A231HDK4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">(2S)-methylsuccinyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mcd_1</name>
        <name evidence="9" type="ORF">B7C42_00075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.12" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46959">
        <property type="protein sequence ID" value="OXR46959"/>
        <property type="gene ID" value="B7C42_00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="49"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="252"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="46439" checksum="9CDF08859CD1DFAB" modified="2017-10-25" version="1">MTSLDVPVHELRRALRTWIAENTPEGLADLIDWRLRADLPGSVASLQSEEDLARAQEHPLFVEWEQRNREARLICPAWPEEYGGRGWEAPQMTILDEEFSRAGLPRIDRVQGESMVGPSIILHGTDEQKAYYLPRIISGEHRYCQGFSEPGSGSDLASAKTRGIVHDDHVTITGQKVWTSRFATANMIFVLCRTDPAAAKHRGLSYVITEFTPGSNGIQVRPIRQITGAEEFAEVFFDGTIAPLSGVIGGLGNGWRVVQSTLGFERAAAGRATTMLLQARERELDQLIALARRTGRHRDPAVRRNLAWAKTQVTIMRSSWLRTVAEVAAGKNPGPQMSTWKLAWSEYHLRLGAIALDIGGPGAMVRPQGPGYTVDQWQDVFLAAHSGTIYAGTSEVQRNIIGENSLGLPREPKFQEGGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDM7</accession>
    <name>A0A231HDM7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776973.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47053">
        <property type="protein sequence ID" value="OXR47053"/>
        <property type="gene ID" value="B7C42_00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018681">
        <property type="entry name" value="DUF2165_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09933">
        <property type="entry name" value="DUF2165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="19805" checksum="4A3E008B803AEF3D" modified="2017-10-25" version="1">MRIGGAGILDVLGSRRTAVAVLATITGFYYLFVAITNCTDTVTNRRGVGAVLSMRATIHNPGTDWRAITNGNIALVVYILVVIWEFSIALVLLAAAACWLRELSGRPRRVPVRPGTAATLSSIGWTMAVLLFAGAFLTVGGEWFRMWANKEVNASSAALQNFLIAGIGLVLVHLPDSPPRAAAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDP5</accession>
    <name>A0A231HDP5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46942">
        <property type="protein sequence ID" value="OXR46942"/>
        <property type="gene ID" value="B7C42_00058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="33740" checksum="1C68D626587B5FB8" modified="2017-10-25" version="1">MILTKTRISVAGMAALAVASFVYMDHLGLETGVMEHVRTVSMAVPDTNGLVVGSRVLLRGVQIGHVTDINSSAEGVSVAMKYDDGYRIPAGSRFQVDNLSALGEAYVAVTPDTESGPYLANHATVNPAEVTVPTTFKELSARLTRMLEQIDPDKIQDIFHELNVSLPDDTQVLGNLNHAGELLATMITNQADSLTTLLTAMQPLLLRSGTVPADLANTTPTIAQFGSSFGDLLNGIRFAQQRGPTTVGIRDGASPFLVNLQGFLDKNATDLHTLGVDLLPGVRAGAAAMSTVNVGQVLDNALAATDSGDSLTIHLHMPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDQ1</accession>
    <name>A0A231HDQ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46888">
        <property type="protein sequence ID" value="OXR46888"/>
        <property type="gene ID" value="B7C42_00001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036170">
        <property type="entry name" value="Prob_YezG_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160424">
        <property type="entry name" value="SSF160424"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="45279" checksum="5A9C375856A57B61" modified="2017-10-25" version="1">MSTDPSSSNVSVRQQELVHQIVENVRSKMVVNTVPLEWTLIDLTWTLIGDDGDLEIGVETADGPFPGWLDQRIGFPPELIQLRDLTHAHEGGTWFTLHLTIPSEGEVTTHFGYVRPQEDSDVEPAALSRTRQPEISEANHRSAVANYQQERIQRIADAVVYVLDANRERLNWTQIELTWTVQDGRALEVEIGITTTDGPFLSWLDLPVGVPHALRDLWHDASVSDRGAWSTLRLVIQAGGEVTTHFGYEPVDSSRYLYTAADPKPHTYPREARPKWIQDLLPENAERYRPLDRGPFASGWSSAAEDFTPDEPGMRYFKVTNPGAAGDKGYEIFSEVDDEGFECRKVQKFRDGRTECVGGFVQTDRTWLDDDLVDLATLSANPNVSAAEITASQFQTEWLAGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEE1</accession>
    <name>A0A231HEE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dgt</name>
        <name evidence="2" type="ORF">B7C42_00433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47311">
        <property type="protein sequence ID" value="OXR47311"/>
        <property type="gene ID" value="B7C42_00433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="75"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="46055" checksum="0E9D15AE9054CBEB" modified="2017-10-25" version="1">MSFDAMPECPYVDSDHERMVSETSPTAGLRWSPSPARRSDFARDRARVLHSAALRRLADKTQVMGPRDGDTPRTRLTHSLEVAQIGRSIAEGLGCDADLVDLAGLAHDIGHPPYGHNGERALDEFADAYGGFEGNAQNLRILTRLEPKVFDAAGESYGLNLTRAALDATVKYPWGRTASGAKFGAYDADLDRLNWVRKGAPERRQSLESQVMDWSDDVAYSVHDVEDGVIAGRIDLRALADPDEQAALAELGQRQHRDLSADDLIAAAQRLSQLQVIAEAAGYDGTLRASVALKRLTSDLVGRFATAAVEATRAAWTGQSLCRYAADLEVPAVVAAEVALLKTVALRYVMSDPRHHERQAEQRERIRFVAERLLAGAPQGLDPILLPWWEAATDDIARVRVIVDQIASYTESRLERIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEF1</accession>
    <name>A0A231HEF1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47148">
        <property type="protein sequence ID" value="OXR47148"/>
        <property type="gene ID" value="B7C42_00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601730" evidence="1">
        <location>
            <begin position="44"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="15020" checksum="A1EFADE882CB1D21" modified="2017-10-25" version="1">MHETTISGPPRQRVRRRAGTVVAGGILGTAAVFALAIPQPANAAVTRLGATPDMNFGIATNYGDGCSYTLQANVTDPVAPVTFYDNGAPIGVAPPGGAYALITWVPAVPGRHTLSAVQAGQPAQMPAATLDLRVGTGIPIGYACLVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEG6</accession>
    <name>A0A231HEG6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47373">
        <property type="protein sequence ID" value="OXR47373"/>
        <property type="gene ID" value="B7C42_00496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082146" evidence="2">
        <location>
            <begin position="32"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="17750" checksum="BF831D5499B56BDA" modified="2017-10-25" version="1">MNVAFGVQCARGAAAAVALAGAIAAAAPAGAAGSLAHEAVEPVAAQCLWADTAHPRGDIVTAGGWSYSCGTDAAGMARWTRGVAAAGPSTVPDPGAATAPAGHFSAGARQPGTEYTDYCVGDQLIEGRDNVFEVAAAGDGLLFWRPVAAADSWTFDPGTHRAPPSARGSSLCRDSQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFB4</accession>
    <name>A0A231HFB4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779530.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47673">
        <property type="protein sequence ID" value="OXR47673"/>
        <property type="gene ID" value="B7C42_00798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="15758" checksum="6B715F9226D3BA33" modified="2017-10-25" version="1">MDLNKYTARLRDDLIAAAALGDEKTQATAAALAAATENSLRLTLLAALSDLADEVNATLDDRTVHVSLSGTDAQVEVRRTASEESHPTFEEMTGDISRVTLRMVENLKARAEEAATQSGQSLNSWLAGAVQGALRDQMRKGGPGRCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFU5</accession>
    <name>A0A231HFU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-phenylpropionate/cinnamic acid dioxygenase subunit alpha</fullName>
            <ecNumber evidence="8">1.14.12.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hcaE_1</name>
        <name evidence="8" type="ORF">B7C42_00945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.19" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042845.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47820">
        <property type="protein sequence ID" value="OXR47820"/>
        <property type="gene ID" value="B7C42_00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008695">
        <property type="term" value="F:3-phenylpropionate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="53"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="460" mass="51202" checksum="F6984D94A93C3997" modified="2017-10-25" version="1">MTAIREPSLSPQVRTLMDRIESGLPDGRIPATIFGNAEVHQAELRKIFGRAWVYMAHESEIEANGDYVVRRIGEDSFVVTRDEKGDIHVLFDACKHRGVQICRADSGNTSHFRCPYHGWTYSSDGSLVGAPLWKNAFGNMSKADNGLAKAAQVESFHGLIFATLDPGAPPLREYLGGMAWYMDLLFGLDKDGVEVLGKPQRFVLDANWKSGADNFSGDDYHLGTLHKSVYAIGAFPVPFSENMMGYHIQASPGHSLSFSMAEDADEPGPKFFGFPESLAENFDTANISAHQLEVARRSRVFVGNVFPNFSILALPMTEDGASHPPTGVLTVRCWQPKGPGQVEMWNWFLGYKNMTPEQKDRAYRAGLGTFSLGGAFEMDDTEPWITVGRTGRSVAAELLDFELNYEMGMPGVGMAHPVQDWPGPGKVYWTRYEEGVQRNMYAYYADLMRAEPGQWPEHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSQ6</accession>
    <name>A0A231GSQ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine monophosphate-protein transferase SoFic</fullName>
            <ecNumber evidence="4">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fic</name>
        <name evidence="4" type="ORF">B7C42_08275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000099">
        <property type="protein sequence ID" value="OXR39656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39656">
        <property type="protein sequence ID" value="OXR39656"/>
        <property type="gene ID" value="B7C42_08275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="134"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="224"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="43069" checksum="E1AB28A1EFC1E7F1" modified="2017-10-25" version="1">MSWPSHRKEKRDWQARVRQGSRADRLLDHIDVSIPPSIAELDFDAVGSVARAQEDAVIAVARLEAGFGAYLAPLADFLLRSESVASSKIEHIDAGWRAFGKAVAGAKASDEALSQLAAVRALALMVDRAAHEEITLEMLLDAHRTLMSPDYYTARDSGQLRDVQNWIGGSDYTPLDALYVPPPPDLVPVLMADLLRFANRTDVPIVAQAAIAHAQFESIHPFTDGNGRIGRALISAIFRRRRLTHRVTVPLASVMLADTRRYFAHLDGYRAGHADELVEYFAHAAIHSSSAAEESALALSGLPQRWAAIARPRARSADEALLEALLDNPILNVEIAQTLTGTTEASTYRALDRLTATGILEVLSESKRSRVWAAVDVIAELDALSAAIGKRTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSX7</accession>
    <name>A0A231GSX7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000100">
        <property type="protein sequence ID" value="OXR39655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39655">
        <property type="protein sequence ID" value="OXR39655"/>
        <property type="gene ID" value="B7C42_08277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="14790" checksum="5A0E75173CC1EC6A" modified="2017-10-25" version="1">MRSGRGRAVSAGRSASDRLVSTREARAATLPASKTRRTGTRVSRAAPSRAATRVALSELPPSAKKSSSRPTRSMPSTSANTAATSSSTTVTGAANTCASNTGAGNALRSSFPEVLRGNESSTVTTAGTMYEGSAEARPARSAVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT71</accession>
    <name>A0A231GT71_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782218.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39823">
        <property type="protein sequence ID" value="OXR39823"/>
        <property type="gene ID" value="B7C42_08111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="16815" checksum="3E33212C036AC8A7" modified="2017-10-25" version="1">MYSRITNPDTGVTITRRSERRLTETVAIEACDTVDFTVAELRDLATATQHLPDTTPVLLIETDGGDRSIHGLSVYYTRDLDAVDPDADRLNMIETLARQIVTDHLAVRFEESAAWTRDGMSDIPQADADAIVARANTFMAAVADAFRKSGADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTD0</accession>
    <name>A0A231GTD0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000058">
        <property type="protein sequence ID" value="OXR39842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39842">
        <property type="protein sequence ID" value="OXR39842"/>
        <property type="gene ID" value="B7C42_08083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="29522" checksum="D107129E81AC5CEE" modified="2017-10-25" version="1">MSKVPLTPMLVQYLTALCCLRRNPDGVDITIGEMVEDEASESVRDVDVTVTISDSGSVTDASMAYEVKHEGPALNVAKVEALCLKLNDMPSITHRAIVSTSGFSATAQKKAARHGVELYQLTAWTRPLQEQFPLLEMTGTVADCFPRHKWLLTWNDYRFALVSVAAQGAFKVVVDNNDAVLDQNGKSHKKYQDFTDYWNELLLCSTEILCRLEPAETVVRTFPLTSSDTPNGPAQSGPRWPHTHTLDVASDEVYFRNGDAVCAWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTE3</accession>
    <name>A0A231GTE3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gdh_4</name>
        <name evidence="2" type="ORF">B7C42_08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000073">
        <property type="protein sequence ID" value="OXR39751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779574.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39751">
        <property type="protein sequence ID" value="OXR39751"/>
        <property type="gene ID" value="B7C42_08180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="27591" checksum="E271312AF0684838" modified="2017-10-25" version="1">MTTLQRYADRRVLVTGAGSGIGQATVLRILSEGGRVAAADISADGLKHTHTKAGDDAERLTTVVMDVGAEDSVKTGVAEAVRELGGLDALVNAAGILRSAHFEQTTVADFEQVIRINLIGTFLVIREALPALREGTGPAVVNFSSTSAQFAHPYMSAYAASKGGIQAMTHALAMEFSKQGIRFNSVQPGSISSGMTDGTGEAKQSVGPGLPADADFALFGKTAPMLPLPDGAIFAQPDAVAAVVAMLASADAYFVTGAELRVDGGSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTL6</accession>
    <name>A0A231GTL6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39959">
        <property type="protein sequence ID" value="OXR39959"/>
        <property type="gene ID" value="B7C42_07966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7387" checksum="A1014C6BB8FFC8D5" modified="2017-10-25" version="1">MHLRYAQHRVAVEYIVQSASQVMVSLKVFVEGRTGAGRCLFDVFALGGPNALQPQALPQVERMLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTX1</accession>
    <name>A0A231GTX1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40042">
        <property type="protein sequence ID" value="OXR40042"/>
        <property type="gene ID" value="B7C42_07887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601727" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="183" mass="19108" checksum="1E13F644722986D3" modified="2017-10-25" version="1">MNPLSAVALTVLAGACLLTACTDHPTGSRPPDQNSCTRAGFGPPFTAVDPCSADSVTAAALGTMFTYRPAEGLDPRRAFEAATPLLDPEFARSGASAATVLAPVTPDMWDRWRDQHVTVTATARATADDHPPDTASRAARVVTVSMQPSDSTPAPRLVVFAVAHRTPTGNGARWLLSKVQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTZ7</accession>
    <name>A0A231GTZ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39961">
        <property type="protein sequence ID" value="OXR39961"/>
        <property type="gene ID" value="B7C42_07968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="22611" checksum="5B1E9FE748F1822A" modified="2017-10-25" version="1">MLGFAIVDRQPAADATAVWLTSRTDTTIVRNTNAVVIPHDDPDHDSKVQWLISERSVVLTEETTPLPPFENAVQVELFEVLVKSTTAHQERICRAVDDYSRRQRSKLVVPVFQPVPELAAAAQDEPRFRALAVANYIGNVWTAWLFTEEQRLRRTVNPRTGETPWIMPEDLNDPAIAIFPAEFSDRVRPAGRDERSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU29</accession>
    <name>A0A231GU29_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH dehydrogenase</fullName>
            <ecNumber evidence="3">1.6.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">namA</name>
        <name evidence="3" type="ORF">B7C42_07788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042679.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40124">
        <property type="protein sequence ID" value="OXR40124"/>
        <property type="gene ID" value="B7C42_07788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018548">
        <property type="term" value="F:pentaerythritol trinitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="411" mass="44569" checksum="B9DF28202203E615" modified="2017-10-25" version="1">MSVTPTPTPPDPLAPATLGPIRLRNRVIKSATFEGVTTDALVTDALIDFHVAVGAGGVGMTTVAYLAVSPEGRTERDQIYWRPEALPGLRRLTEAVHATGAAISAQIGHAGPVANSRSTGLPSLAPSTRPNPLSMSLDRAATEADIRRIIDDHARATRYAIEVGFDAVEVHLGHNYLASSFLSPKINRRKDSWGGPLHRRAEFARRILQAVREAADGQIAVLAKMNMADGVPGGLWLDESLVFAQMVESDGHVDALELTGGSSLLNPMYLFRGDVPIREMAETQSGLVKLGMKMFGRFVFEHYPYAPLYFRDYARQFRNELDMPLVLLGGITDLAGMNTAMSDGFEFVAMARALLREPDLINRIRAESSKTSLCIHCNLCAASIFTGTRCPLVSTDVRSDVTDEKPLGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUG3</accession>
    <name>A0A231GUG3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40269">
        <property type="protein sequence ID" value="OXR40269"/>
        <property type="gene ID" value="B7C42_07694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="9657" checksum="840670E068193971" modified="2017-10-25" version="1">MGEEIAVGDQIEWYSDIDGRPVEPDDPEARTYTGIVDSVHRHRDDSRVVAYLVRCRGGVSGTYLSTVLPEHRPSVVDSGRQQDGSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUP0</accession>
    <name>A0A231GUP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase PknL</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pknL_2</name>
        <name evidence="2" type="ORF">B7C42_07605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909899.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40344">
        <property type="protein sequence ID" value="OXR40344"/>
        <property type="gene ID" value="B7C42_07605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="31945" checksum="71ABA751B71C0277" modified="2017-10-25" version="1">MNLHPLHPATSVTDGLADSGWRIIELLAFTRSSTLILASQDDNEPVVIKAGFGSNHVLAEMDEQDRPAAYGFYWYQQMTPAERVLSREDFRHERELARDCRGATRVVYLIDEGECGGFDWYTMPHYPDGNLRAFTTQNASPAGLGASMTILADVAAGLDELHRRGIVHRDLYQENVLLKNGRGVITDLGAACRIGEARGPRRRGPEVHWPPEYAHSYAEATPGADVYSLAVLAYRILFADLPRLDGPRHLDGLPTTVTDHITAALANNPDARPTMTELHTSFLEGATATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUS3</accession>
    <name>A0A231GUS3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40379">
        <property type="protein sequence ID" value="OXR40379"/>
        <property type="gene ID" value="B7C42_07545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="3">
        <location>
            <begin position="223"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="36152" checksum="ED974AD72CC78FA2" modified="2017-10-25" version="1">MTRYVIVGAGAVGTTLAVELADSGQDVLLIARGDALRYFRQHPVKYHTPTGIRNVRLPVAATTDDLALHTGDLLVLTAKTQDVGAAAEDMAWRDVRNPDGAVTGLAADHIPVVTVQNGLAAEGMVARWFATVIGAVLLVSARYERLGEIHVGASPTVGAMIAGLATGDSARGGSAVATLVDDLGKANFHAEAVPDIRAHKAAKILHSVKNGLEVLSGDPSAKAAVGAALVTEARLVLAAAGITFHEPVALASVFSRQRATRNTAPPGRQSTWQSFARGAASNEIDYLNGEIALLARLHGVAAPLNTTLQQLLGRATRDGGGLDLPGLKTLTNLLPVSDSAPRAGELLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUU4</accession>
    <name>A0A231GUU4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione transport system permease protein GsiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiD_6</name>
        <name evidence="7" type="ORF">B7C42_07563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40397">
        <property type="protein sequence ID" value="OXR40397"/>
        <property type="gene ID" value="B7C42_07563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="309" mass="32350" checksum="F713E7D38DC5E2A2" modified="2017-10-25" version="1">MTTLRALLANPSARVCLLILAAVAFLAVFGSALAPYDALWQSPQILQGPSADHLLGTDYVGRDVLSRLMAGTRLSVVGAIEAVLVGLCLGVPSGLASVWAGRAGEWIGLRISETLTVLPFTVFTIAVAATLGNGMNQAMVAVGILSAPIFFRISRAVALGLRSTQYVESAELMGASTWWILRTHMWSKVAPNVAVAAAQATGAALLVIASLAFLGVGITPPAPTWGGMLASDLGYLELQPWAPLLPGIPMLLTVGALNILADCLREASSDAPRARRGLFARLLGRGLSLPATVTKPAFPTEEFDRVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUZ8</accession>
    <name>A0A231GUZ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease protein DppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dppB_2</name>
        <name evidence="7" type="ORF">B7C42_07564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40398">
        <property type="protein sequence ID" value="OXR40398"/>
        <property type="gene ID" value="B7C42_07564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="117"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="35887" checksum="270B6E238636F3BB" modified="2017-10-25" version="1">MTEASAAPLISGAPKQASLGLPVFRAGARLLLTSVTVLFLASLITFTLGALSKNNPAAVVLGDTATPEDIARLNHEFGLDRPLVVRYLAWVWDALHGDLGRSWFTTVPVSRSIQLAFPVDLSIALYALLLALVIGFGAGILAAARPGGVIDRIITVFCSVLATLPPFVIGIALIVLLAVKARLFPAGGYSPYAIDPVHWLRYATLPALALALEVAANIARQLRTTLVSAQAENYAIGARMRGYGRGRVLFGHVLRNAVAPTLAVVTNALPLIIGGAVMTEKLFNLPGVAQLALQSAQRGDVPVVLGTLLVTSAVVLLGTLALGALQILLDPAARRGTIPGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV16</accession>
    <name>A0A231GV16_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein OppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppF_2</name>
        <name evidence="6" type="ORF">B7C42_07561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40395">
        <property type="protein sequence ID" value="OXR40395"/>
        <property type="gene ID" value="B7C42_07561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="36901" checksum="B651D8580BAC5CBC" modified="2017-10-25" version="1">MSTAPLLRITDLSVTYAVPRRGVGLGTGAALQGASLEVYPGEIVKIIGETGSGKTTLARTTVGLTAPAGGTIEFDGRELTGLRGRELRKFRRQGRIQLVFQDPLRSLDPDLTVARLVGEPLEVAGGIDSATRRERTDRALREVGLDPDTVRERRPRELSGGQRQRVSLARAIVTEPQLLICDEPVSALDVSNRNLVLNLLDRLRRDLGVAVVIIAHDLSSLAGIGDRVAVFYRSRLVEQGPLRDVLTRPAHPYTALLVASAPSLGTQSAIRPDDIRGEREPAPTGGCVFADRCRFAYTECATQPELFEVEQRWSAACHLAGRWSGTASENSHTTLTKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVA8</accession>
    <name>A0A231GVA8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778572.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40411">
        <property type="protein sequence ID" value="OXR40411"/>
        <property type="gene ID" value="B7C42_07469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="14855" checksum="4D0FDAA1FD775933" modified="2017-10-25" version="1">MVAEAAVFRFSKILVENTEAQFGFYSSVLGMMEKYRVRTGEGDDSLEEIIMTSAHGGDPALVLLHYLNRPAPSPGEAVLGFNVDDVEAVVRAAEKAGGTVAVPPKEMPEFGIVVAFVEDLEGHRLELVQRLPVAAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC2</accession>
    <name>A0A231GVC2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional ligase/repressor BirA</fullName>
            <ecNumber evidence="5">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">birA_5</name>
        <name evidence="5" type="ORF">B7C42_07347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40538">
        <property type="protein sequence ID" value="OXR40538"/>
        <property type="gene ID" value="B7C42_07347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="35535" checksum="7821633C1887F454" modified="2017-10-25" version="1">MPETTPARLLRLLSLLQTHRDWTGTELAERLDVTTRTVRRDVERLRELGYPVHGVMGPEGGYRLGAGASLPPLLLDDDEAVAVTIGLQTNTTGNVAGIEETSLRALTKMEQVLPARLRHRVDALRGAVVAMPPRYDPGPAVDADQLTAISAAIRAAETLRFDYRSHAGEDTRRTVEPHRIAHWSHRWYLVGWDSDRADWRTFRVDRMSLRTPNGPRFTHRPSPDGDVVAYLRRTMGFAMWPYRSVMRVHVPAGQLAGRIEGLVTPIDEHTCRLEMGSDSYALVALAVGMLDVEFEVESPPELVEHLRALAGRFTRAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVH2</accession>
    <name>A0A231GVH2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40630">
        <property type="protein sequence ID" value="OXR40630"/>
        <property type="gene ID" value="B7C42_07315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="7609" checksum="74A9EB39FAF9DC03" modified="2017-10-25" version="1">MTIHTASEPCGSAGSRPPRPYDEADLSSTAFWASSASERESTFAEPEPPECHRALIEEAVSACPTGALSVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVJ2</accession>
    <name>A0A231GVJ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="10">R protein</shortName>
            <ecNumber evidence="10">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hsdR_2</name>
        <name evidence="12" type="ORF">B7C42_07334</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HsdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064908886.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="REBASE" id="234279">
        <property type="entry name" value="Nce30759ORF7336P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40649">
        <property type="protein sequence ID" value="OXR40649"/>
        <property type="gene ID" value="B7C42_07334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="277"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR40649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113789" checksum="F7F0C04305A614ED" modified="2017-10-25" version="1">MAKGIREREFQNRMVQWSLPLGWAFTAGRTLPREATQTVITSQLRDAIVRLNPAVIDGFDVDAIVEEIVATVNAVEGGLVRANEQVLHILRGLKEFRNADGVWHGLRVIDFEHPTDPKANTLVVSDEVTITVPGKTSRRFDLVYWVNGLPLVVVEVKSPTAKSGWADAAREINNVYATEYPWFFTPNVFSVASDGLKLRFGAAGAPTNLWQPFRSTADDENLSGQPDVQRSVELLMNPVTVLDMLANFALFDTSGGGVDMKYLPRYPQMEAAHLIHKRVLEDGSKGLIWHHQGSGKTLLMVFAASLLLADTRTESPTIILLSDRTQLVRQTSGVFTSAMGDAYFHQPTTSQELRSLLADDVRGVISTTVHKFADVGKNLSTRSNIIVMVDEAHRTQSTRSKSLAGQMRAALPRAKFFGMTGTPVRNLATDTFSLFGAETDPSRVLHRYSVSRSLLDEATVPVMLDPHPVSFEMNDRELQTEFDRFADEFDLDDPDRETLSRKFGRLTSVFANPDRIHAVCQDIVDHYLAGPYRNGLKAQVVAYNRELAVAYTDKINELLAGFETSQVLAAVGKHDRITAEVNISVSDSKDEDPAMRPFRLSENEEEEQKRRFLRPDDPLCFLVVTAKLMTGFDAPNEGVLYLDKPLKAHSLFQTITRPNRTWVSPTGFVKAAGVVVDYIGLAAEVQRAVADPTPAEADRGGGFVIDVSELVAEFRTTFASIEDMLADVDGLDLAVHGYESVRAINSCLDANPGAAEVFTKNYQLLARLYPFVNTDKRITKYQDGFGLFGSVYTTLLKKSSDEDRRERLGELGPMVLEIINGHVHSFSVVASQEEPLVLDAQGIAILKELLALVRRKPGKGDGEEKTPPSAAEILRHIKAALDEGVEPGSAKYTALAERIRLLRDRIIQNSHDALEFLSEALRIARAIVNAQKHPDEAVVLDDDHVGVLTRIIHDHAPSGLTVTERNLAEEIDRVVTNTLARSWDNADARNRGARRATAAVFRRYMLKPVGEPYDSTVAYIEAHYLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW01</accession>
    <name>A0A231GW01_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782246.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40661">
        <property type="protein sequence ID" value="OXR40661"/>
        <property type="gene ID" value="B7C42_07218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8558" checksum="D74A3B1AD8554139" modified="2017-10-25" version="1">MNDHGLLSELRESAWYTTEEVAAMLKVDASSLRRWRTARPPQGPPFVQLSDRVTRYSGADLIEYLSHRRIDPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX31</accession>
    <name>A0A231GX31_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41159">
        <property type="protein sequence ID" value="OXR41159"/>
        <property type="gene ID" value="B7C42_06755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="11142" checksum="65C84ADFC2E8DC86" modified="2017-10-25" version="1">MKNVNYRDLVDDRLGKMTPDQRAEYDEAYERAGLALRLAELFYDARAAAGLTQTELARRMGTTQPTIARIEGGGRMPTLDMLERLATAVGQRLDISLGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX48</accession>
    <name>A0A231GX48_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821361.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41186">
        <property type="protein sequence ID" value="OXR41186"/>
        <property type="gene ID" value="B7C42_06782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="25442" checksum="9A39C4FCA27EDACB" modified="2017-10-25" version="1">MTDPGGVTVADTVRWLHGEGLVRLAGLAERTPDLLAAYTIDVATGTVNAYPVTGAGAGSAAMTFAADDLPDPVGTARRLVVVGVTSSQAVLVVDLAASLAISITSARPEPAARSWVLQLLLNPEVTITTNSAELTPASDPRCRTSFIPGSSATIVNVDDMQPPLTTITLNPATDGPDHLDVGPDGTGEMYLGTRFWQLHQVMTVGDEAWSAISARLSGTADDAVASGQPPGPAVSAPPGRVSAPGVVTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXF6</accession>
    <name>A0A231GXF6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein LiaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">liaR_7</name>
        <name evidence="5" type="ORF">B7C42_06660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41262">
        <property type="protein sequence ID" value="OXR41262"/>
        <property type="gene ID" value="B7C42_06660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="293"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="39764" checksum="50054C83C62573B1" modified="2017-10-25" version="1">MSTGSAHRALETLVTLDRELRDTMDLGRQPDVSTLAEAIVMSDKTIDVALTARPIPDSSADIARAGLIAAVLDAQARVRELIRRARSRRIPELSRAVTRMRSAASVEALIRQTCSELTGTLEFRRASYSVIDDAGCTLRYVHPGTGSPPSPSCDPRQPNAAEQDCLIERRSVLVDSTAGEQSHDYIAKILDTTHYVVAPVILGSDARALIHAARDLPWTVDSTDLRLLDIVAATFAVIHEREVRADRMQRQRQSILAAVRQLASETDSFAGLDVDLGLEGTSIRPGSPAQPIRAAVHELLTPREAEVLGLIVDGASNNEIAEQLVITVETVKSHVKQVLRKLGAVNRSEAISLYLEEQRRAGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXG9</accession>
    <name>A0A231GXG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative enoyl-CoA hydratase echA12</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41314">
        <property type="protein sequence ID" value="OXR41314"/>
        <property type="gene ID" value="B7C42_06712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="28205" checksum="5D2E3DFCD3B0EF7C" modified="2017-10-25" version="1">MKTLEHRFETFLAEEVKPGIVVVTLNRPERYNAMTNTMFVELEQLAWGLETEDACRVVVLTGAGKAFCSGYDLADADDLPNLGALGMLDQQERAARALTAIRSLRVPVIAAVNGPAAGGGLALALAADIRLAGPAAKFNAAFVRIGLSAGDLGTSWLLTRLIGPAKTSEICFTGRIVDATEAGELGMVNSVSAGDVVADALALAEQIVANSPGGVQLSKRALQANLEVGSYAAAIELENRGQALLTRSPDMAEALNAFKDKRPPVFQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXI0</accession>
    <name>A0A231GXI0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_32</name>
        <name evidence="1" type="ORF">B7C42_06704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41306">
        <property type="protein sequence ID" value="OXR41306"/>
        <property type="gene ID" value="B7C42_06704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="26904" checksum="B74CD5B37C85E8A8" modified="2017-10-25" version="1">MTDQPVETPTVAPGIEVFGLDGRTALVTGAGGGVGAAVAEAFAAAGASVLVTDINKDAAAAVSERITKAGGVAEPFTLDVCDGDNARDAVAAAARLGNGKLNILVNNAGVIAPAMFPKMDEDRFRKVLDTHLMGSYHCSHAALDYLAQDGTGRIINVTSAAGLTGTIGQANYGAAKAAIVGLTKSLARELARQSITVNAVAPLAATAMTENIRSNEKLAAKTLARIPLGRWAYPDEIAPTFVFLASSAAGYITGQVLPVDGGTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXS4</accession>
    <name>A0A231GXS4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41399">
        <property type="protein sequence ID" value="OXR41399"/>
        <property type="gene ID" value="B7C42_06542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="465" mass="46746" checksum="3C37E71AD5DE5C10" modified="2017-10-25" version="1">MHRVSGNGTPPAQGHTDPDYAPTVEMFDHLTHRDIQRGVQELNPEIITAGRQAWQSSAAAMADAVQSAHTEIRGAIADGWRGGAAQLAADAVTAFERLGQQLSDVMAVVGQRLAQANDAAETLRASVSQQVTAHPDLEAALLDPKQATAIAAVQKSAENVRQDAVRVMDSVYAGVFLRTGDSVPAFPDGGMYPNPAVVQPGDEATAPGGGSADLIGRATGARVAPTVDGPQAPEAAADRPAAPADDPAGGDRSGGDQPGGDRPGGDQQATDRPAAVAPAAAVPTLAEPSTPVPTPVHGTLAAAAVPEAPLVSNSVVTQPRPPSAAQPAPAASAPAGGVVPAAAAVGPAGSATTPATAAQNSDSTKRDDDQDRNPGADSMSGMGAGIVGGLAGGAFAAGDAVRPGPATPVAAKPIRRDDDEDEDEDYYSEFDDEPTFLEPAEPGGELVGILDPTTPPVLGEWSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY04</accession>
    <name>A0A231GY04_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41455">
        <property type="protein sequence ID" value="OXR41455"/>
        <property type="gene ID" value="B7C42_06346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="27"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="32752" checksum="FED65F5DDE53DBEE" modified="2017-10-25" version="1">MNRAARIVAPAPAPAPDAGLARRRQYMAGPAALLGGPANVVMQLGLPPVGRGVVESTVESGQYARHPRKRGRTTLTYLAVAMLGTEEDRIAYRAAVDTSHRQVRSRPGSPIRYNAFDPQLQLWVAACIYRGVDESTRFFYGRIDDNLADEFYRESARFGTTLQMPERLWPPDRAAFDEYWHAKLGEISFDDEVRRYLLDQVIGLGPYSRAQRIAFARVNRFFTTGFLPQGFRDALGLGWGPRRQRTFEIVMRTIGTVLKRLPEHWRSYPFDGYIEDMRRRQALGKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY58</accession>
    <name>A0A231GY58_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780893.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41563">
        <property type="protein sequence ID" value="OXR41563"/>
        <property type="gene ID" value="B7C42_06456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="34539" checksum="694D3EA13D521DEE" modified="2017-10-25" version="1">MKRETAASLGAIATVLVLGAGYLAVGVVRVDWLRDYLRVSMALPNSAGLLEKSPVLYRGVRVGDVTAVRPADRGVVVDLRIEHDYRVPASSSVVIEQLSAMGEPYLEFRPDAAAGAPYLADGQRVDAKQIRTPVSIPDMADAVTRLLQQFDPQALSELIDTLSQGLAGTDRIIPELGRSTGLLAATLLSRSGEMRTLLDQLQRIAADSEWIGPAVAASGPYWGLFGGKVSEVVGVVENVMIRNHEGGTMPEDYVHGDGILPFLNRLVDFLHESGPQLQQLAPALRPLAESATAAAGRIDLSTLISQALHATTADGALHLRIAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYL2</accession>
    <name>A0A231GYL2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41713">
        <property type="protein sequence ID" value="OXR41713"/>
        <property type="gene ID" value="B7C42_06055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="477" mass="52246" checksum="2DA59A60B4431637" modified="2017-10-25" version="1">MRRVRHLGQPPQLTQGVIGIRGGERCRGVGSEHPVQTPGQRLARRDERLAKMVEPVLLVRRQGIGARGLPGHRLDSVVQIERLRDPGDQLRGVHCRKNVVGSLGDALPDGVHGGANRSHDHDRYGRRQQFGQNLPSGRPDRAVGGGAGSHRVVGLCPGILRSGRPRIVSVDRCRRLRRSCLGRNSLGDRKFGGGRVQWPVGGVGPPVLPQPVGLGREIALPDFGGNLEAAQNAVVAQASRPVHGDDVAVLVHHSEPAGRVDDVDPVDDGPLRGRGVHHHRLAVVARAIHPHRRVDDLAVALGERDESVRRRDGKWPRVAPEQQAPPGAPPRSDIVLRDRAPPPANGVEVDIRIGGRREQNIVRHLTDLLPVHRCRRAVEDPPQHLIDVERSRSGVGRPVSDRTIGRIRPRIGRPSRQPPIRLARNGLRCRSRPRPADGPEMRHGSVENPAGGTVVRELVGQRHGRRRVLDERAPQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYQ4</accession>
    <name>A0A231GYQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41754">
        <property type="protein sequence ID" value="OXR41754"/>
        <property type="gene ID" value="B7C42_06096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="14729" checksum="B93A151ABD31CD5C" modified="2017-10-25" version="1">MTPEQEAILRDVQAQLRGPGLAGWPQLGDDGTDGGPISERTVVEALGAALRQIAELRTEIADLETTVLELTRQAPPVAELPWPLSLVAALLENPAAVIGEQIARWESLLEALRPKPDDAPQPGQRALEAPRSPARHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYR0</accession>
    <name>A0A231GYR0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41661">
        <property type="protein sequence ID" value="OXR41661"/>
        <property type="gene ID" value="B7C42_06302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="41"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="479" mass="51557" checksum="EE2A36AC90D3A9B8" modified="2017-10-25" version="1">MPTDEPADSSPTDSGTRATVRDLPVTDRDRGENDCPDIEFTDVVVVGARCAGAATAIAFARAGRRVVVVDSARFPSDTLSTHLLWPAGLAEVAALGALERVLALGAPRLRVAFAAGAGQVVRAPFTAVDGIDYAMCVRRTGFDAALVSTACAAGATVHESMRVTELIRDGGRVAGVRAVDRAGTTHEIRARLVVGADGRRSTVARLTGALDPYRSKPSGRACYFAYWRDGRPEWRSTAAQWRAGDLLGTAFPCEDGAVLSLIQPPVAHGPRTAGQTEQRYRDMVAAIPELAVRLADCEPIGRVRSATGIVSYFRRSSGPGWALPGDAGHFKDPVTAQGMRDAMRYGRLLGECAAPVLDDAAALDRALIRWEHRREQDCLPMYQWTNRLARGTEMSPLEVQLYRAGAADPNLAGLALDVMTRARTPDELLTPARAAKFALQALAHAPATTVADTVIREVRDSARDWRERQAARWGSAWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYW3</accession>
    <name>A0A231GYW3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Decarbamoylnovobiocin carbamoyltransferase</fullName>
            <ecNumber evidence="4">2.1.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">novN_2</name>
        <name evidence="4" type="ORF">B7C42_06122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.12" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41780">
        <property type="protein sequence ID" value="OXR41780"/>
        <property type="gene ID" value="B7C42_06122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="143"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="422"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="598" mass="65580" checksum="3EE134F27251A365" modified="2017-10-25" version="1">MVRTPAAQPKSIMGISGLHNSVPFKRARFPGLEWRDYRITQGFDSAAALLHEGELVSAVAEERFTGEKATGAFPEHAIRFGCERAGISVDSLDVLAHGFSYEPLRAAFDHSELGRARFREVFARQVLLDKLAETFGGDWDDRLVQVPHHLAHAASTFYPSGFDSALILVADGMGEQHSATVALGTDAGIEPVATVSELNSLGILYGVFTYYLGFAFGLDEYKIMGLAPYGDHRKHFAAMMDLIHLRPDGTFTIPILYRNETDLDRETYRGTLKAVEEIFGPARGPEDELTDHHRDIAAALQAALEATLLHTLRHFRKQTGAKNLCMAGGVALNCTANGVILRSRQFKRMFIQSAAGDDGTALGAALYVHHQRDQAAPIAGIETPLNGPEYSDEEIAAALAARTDCTATRFDDFATLAGELGRRLAAGQIGALFQGRLEYGPRALGNRSILGDPRHPRMRDIINAKVKKREGFRPFAPAVLDEYATTYFDIKDAEIDTYAWMLFITSVRPEFREGLPAVTHVDGSARVQTVSRQRNERFWTVIDAFRQETGTPILLNTSFNVKGQPIVCTPAEGLDTFVTAGLDVLAIGNYLVEPVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZA8</accession>
    <name>A0A231GZA8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-[acyl-carrier-protein] desaturase DesA1</fullName>
            <ecNumber evidence="8">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">desA1_5</name>
        <name evidence="8" type="ORF">B7C42_05928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779011.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41944">
        <property type="protein sequence ID" value="OXR41944"/>
        <property type="gene ID" value="B7C42_05928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="36236" checksum="20BE21D0FEBFB349" modified="2017-10-25" version="1">MARELTQREILTELEPVAATALDRHLSMAKEWHPHDYVPWDAGRNFAMLGGTDWEPGQSTLSDVAKAALVTNLLTEDNLPSYHREIAENFSQDGAWGTWVGRWTAEENRHSVVLRDYLVVTRGVDPVALENTRMTHMTNGFTPGVARLLDGEAGFLYSVAYVSFQELATRVSHRNTAKVCDDPIADRMLQRVALDENLHMIFYRTMCAAALDLVPDQAMTAIDIIVENFRMPGAGMPDFRRNGVLMAKHGVYDLRQHYEDVLEPVIRQWNIFGRTDFGPRGEQARDRLGAFLENMELVQIPRFEEHRDRALARERART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZD0</accession>
    <name>A0A231GZD0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stress response protein YsnF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ysnF</name>
        <name evidence="4" type="ORF">B7C42_05948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778993.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41964">
        <property type="protein sequence ID" value="OXR41964"/>
        <property type="gene ID" value="B7C42_05948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019060">
        <property type="entry name" value="DUF2382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09557">
        <property type="entry name" value="DUF2382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02271">
        <property type="entry name" value="TIGR02271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2382" evidence="3">
        <location>
            <begin position="144"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="30130" checksum="947B378FFA95054A" modified="2017-10-25" version="1">MTGQLDTLMDSTVYDSHDDKIGKVKNIYVNNETGSPTWASVSTGLFRHDSLVPLVGAQHNPQSDALRVNVDKEMVKSAPAVEQDGHISREGEEQLFRHYHVDPNHSGWDAYGRAMRDGQGTARPDAAPSGRHAATDPTGDQGLIRSEERLNVDTQREEVGTARLRKYVVTEDQTVTVPTSHEEVRVEREPVTDAGAYGQTSLGDEEREVTLHRDRVTVDKETVPVERVRLAVDDVEEQETVGDTVRKERIDTEGTDPGRYDDRRYPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZF6</accession>
    <name>A0A231GZF6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778961.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42006">
        <property type="protein sequence ID" value="OXR42006"/>
        <property type="gene ID" value="B7C42_05990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11461" checksum="72DEA3A5A993315D" modified="2017-10-25" version="1">MSAEPDKSKWPKAIGYVRSDLAGDRRTEIDAAIRRRAAGAGYRLMGIVADGPVPDLLPALRRADAVAVITHDLEHVGGSPKSVCGFAALLTVDPADMWCWGYQPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZH7</accession>
    <name>A0A231GZH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase-like protein</fullName>
            <ecNumber evidence="3">1.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41921">
        <property type="protein sequence ID" value="OXR41921"/>
        <property type="gene ID" value="B7C42_05905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="42871" checksum="BE622DE0632382CB" modified="2017-10-25" version="1">MSDLEGVACLEGMTDFNAITKVVVIGGGYAGAVAANRLRLRSDVEITLVNPRPQFVERMRLHQFVAGTHEAAIGYDTLLGAGVRLIVDRAVRIDTAARRVELGSGRALDYDYVVYAVGSTAAVPASVPGATEFAYPIAEFEHAQRLRAALADVPARAPIVVVGGGLTGIETAAELVEQGLVVTLVSGGKLAANFSNPARRSVAKWLSENGVEVREQARVGEVRREGVVLTDGEWVPGAITIWTAGFGVPELAARSGLRTDGLGRLLTDETLTSIDDERIVAAGDAVAPSGRPLRMSCYAAQPLGAQAADNVLARIAGDEPAVLDVAFTACTVGLGSRAGAMQFSRRDDTPVPMYLGGRTAGWIKERVGLAGPIGTIRKEARKPGAIPTFLGLGRRKDLSAAEPQGVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZJ3</accession>
    <name>A0A231GZJ3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042727.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41995">
        <property type="protein sequence ID" value="OXR41995"/>
        <property type="gene ID" value="B7C42_05979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="120" mass="13125" checksum="26D2C81213D69690" modified="2017-10-25" version="1">MTNSNTPSVPATDAPVTVINTMSVPAAQRDLFLQRWRDSAQYMAAAAGFRRTRMFQAAGEAAEAVFVNVGDWDSGTALRNALGTAEWRELTLRMQNDLDLTARPMIFHPTLELGPGEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZL7</accession>
    <name>A0A231GZL7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetophenone carboxylase delta subunit</fullName>
            <ecNumber evidence="2">6.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">apc4</name>
        <name evidence="2" type="ORF">B7C42_05665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42066">
        <property type="protein sequence ID" value="OXR42066"/>
        <property type="gene ID" value="B7C42_05665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="1">
        <location>
            <begin position="47"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="780" mass="82947" checksum="06BA1183249FAF4F" modified="2017-10-25" version="1">MFIPKPVPVPGSEMYASRDISAEQLRAAVSPKLPLHEIDASASERVDALTYEVVRHRIWSITDEMGQTLRRMSGSPGVTESNDFGFAICDELGNEVQVGLANTGIVASMDLAVYWILQHRSHNPGIEPGDMFLTNDPWTGGGLHQNDAAIIAPFFWEGELFGWTSSCCHLIDVGGSKAGSADIMALDVFSEGAPTPPVKVVRQGTIQNDVLESFTRRSRMPLLVNLDLRAEISANLTAQAGLRKLIERYGPTTVKAVMKRMMDDSEAQLRERLRAIPDGSWSSTGYIEQAVVGDRNLYNLELELTKKGDHLTFDFRGTASSVGMVNSPYSGMRAAVLVGLLPILAGDIPWSTGGLMRCFDLISDEDTISNAAFPAAVGWAPISAMWGSSNLVVECMGKMLDTSIELRSRSQSVCTGSYDIVTMAGVDENGNPFVAIDFDGMAGGYGATPEHDGGDTSGILPIPMGRAPDVEMQEFLNPYLVLWRREEPDSGGPGQFRGGVSLAEALSPHRTPAPMFGSFMGSGKARPDASGLAGGYPGGCQLDIVVRDAEVAKLFAEGRVPTSVEELGGTQEVVPTRYETQIGVRDVVFIHPGGGGGFGDPLLRDPAHVARDVASGRVTPGSAEQIYGVILGPDGTVDAEATATQRTSLRKARLGPQAGELRSVKSDATELDSDTYLDTNFTIVEGPDGRAVACRHCEITIGPAAADHLGALHVRTGEPAEGGSAVWSDPRLHIDSDTIFRQLCCPGCGTAVHTAVVPAHEPVLGRDGHSSCHGGAKVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZX6</accession>
    <name>A0A231GZX6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42102">
        <property type="protein sequence ID" value="OXR42102"/>
        <property type="gene ID" value="B7C42_05701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="180"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="41844" checksum="46DB4FE226B1C26A" modified="2017-10-25" version="1">MNDPHDPHADLHSEHGAVVGEHPGRALNPIVKVYDLAWLEFEKRDLVGAEKFATAFGFTTIMRTPDELHLRGVDAGSPCVIIRRGARSRFVGPAFSVADRKDLARFSAATGAAAAPLPESLGGVRVDVADPSGLRVRLVSDTRVHAELPAQPPHTLNVGRALARANRTQRPPREPSRVQRLGHVVVQTTTYRQTLDWYLQYLGMIVSDFQYYRGQRDRGPVMSFIRCDRGRTPADHHTLALVLGPRNRYVHSAYQVADLDALAAGGEYLRDSGYRRSWGIGRHIQGSQLFDYWRDPDGLLVEHFTDGDMFDCTVEPGWAPMTASGLAQWGPPVSRDFLGIGPSREMLREARAALGALRDDNEFDLRRLRGLLKVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0E0</accession>
    <name>A0A231H0E0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42307">
        <property type="protein sequence ID" value="OXR42307"/>
        <property type="gene ID" value="B7C42_05506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16652" checksum="8CF751BEF25EEAC1" modified="2017-10-25" version="1">MPEYDTNFTRKDLRIPIDFSVFFGAGLYQMGPVRLDREYTGNPDRPGAQRRDEVTELPQWKISVMDPGESNARRTGYEIVLLSDKEPVPTTAEIGPNLRPIELTGLTIQPRVAGQGEYKYQSYMVRATGYASAPSTGGRGSSSGAGKSASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0J7</accession>
    <name>A0A231H0J7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable hercynylcysteine sulfoxide lyase</fullName>
            <ecNumber evidence="2">4.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sufS_2</name>
        <name evidence="2" type="synonym">egtE</name>
        <name evidence="5" type="ORF">B7C42_05605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:42688"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="ChEBI" id="CHEBI:134344"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42404">
        <property type="protein sequence ID" value="OXR42404"/>
        <property type="gene ID" value="B7C42_05605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990411">
        <property type="term" value="F:hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02038">
        <property type="entry name" value="EgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027563">
        <property type="entry name" value="EgtE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="42195" checksum="29E18B983CAB1925" modified="2017-10-25" version="1">MLDTDRLRADIPAYDTAGPPPVFLDSAGSSLPPRIVVDTAVAHLRREAEIGGYRAASERLDDLAAVKTAIATLINADASAIALSDSASRSWSDFFYAVPLRPGDRILVSGSDYASNVIAALQRARAAGATVEAIPSDDTGQIDLVALDSMLDDSVKIVSLLHAPTNGGLVNPVAEATRIAHRVGALVLLDACQSAGQIGIDVAELGVDAMSATGRKWLRGPRGTGFLYVRPDVCRELEPSRLDLHSAAWTGPQDYRVAPDASRFEFWECDVAARLGLGAAVNYLLDLGPENVYADVAAKARHLRENLPSIRGITLRDLGTEHSGIVSFTVDGVDPGQVRETLRAADITVTVSYRSSTLLDMSARRLESVVRASPHCFVTLEELDRFLEAVDRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0V1</accession>
    <name>A0A231H0V1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_5</name>
        <name evidence="2" type="ORF">B7C42_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42504">
        <property type="protein sequence ID" value="OXR42504"/>
        <property type="gene ID" value="B7C42_05280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="35059" checksum="8DDCA47B1F4A920C" modified="2017-10-25" version="1">MIATRKLGELTVGAQGLGCMGMSQAYGVRDNDAESIATIHRALDLGVTLLDTANVYGAGDNEELVGRAIADRRDQVILATKFGIVWGEGGSMGARGDAAYVAQSCDESLKRLGVDHIDLYYQHRVDPNVPIEETWGALSELVTAGKVRYLGISEASAETIRRAHAVHPVTALQSEWSLWTRGIEEEVLPTCRELGIGIVPFSPLGRGFLTGSITSTADLPADDLRRALPRFADDNIDRNLAVVAELRAMAEEKGVTAGQLALAWVQSRGDDVVPIPGTKRRTYLEQNVAATEIELSAEDLARIEAAAPAEAFAGARYPEHLARAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1E6</accession>
    <name>A0A231H1E6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505631.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42670">
        <property type="protein sequence ID" value="OXR42670"/>
        <property type="gene ID" value="B7C42_05448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="12340" checksum="4B0D4DD618A713F9" modified="2017-10-25" version="1">MSDSGSDIDVEVPASGTGCAECVAAGGWWVHLRRCARCGHVGCCDTSPAQHATAHFRSTGHPIIQSFEPGEDWFYDYRDGAVGEGPELAPPTSHPETQPVPGPAGHVPADWQDHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1X0</accession>
    <name>A0A231H1X0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">icaR_2</name>
        <name evidence="5" type="ORF">B7C42_05179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42841">
        <property type="protein sequence ID" value="OXR42841"/>
        <property type="gene ID" value="B7C42_05179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="216" mass="24756" checksum="DFD45BD36A886012" modified="2017-10-25" version="1">MSVRASIIDVMPSESTARRGSLRDEQKRATRMRIVEEARQLFAREGYLGVRVDDIAAAVGCSRATFYLHFTGKTEVLRAIAEQGTLASVQFFYRDLDRVLATGSRAEFTTWMRRAIEWFFDNKDLLPAWDEATALEPEFRDLAREGIMQLADGMPDYLARWPEDRRDEARLRIELLVAQLERFFTRWAMQGTIEVTAAAAAEVLTDIWFPALQAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H259</accession>
    <name>A0A231H259_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4873 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42929">
        <property type="protein sequence ID" value="OXR42929"/>
        <property type="gene ID" value="B7C42_04815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032371">
        <property type="entry name" value="DUF4873"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16170">
        <property type="entry name" value="DUF4873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4873" evidence="1">
        <location>
            <begin position="202"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="31870" checksum="EFDB550098E0B2BA" modified="2017-10-25" version="1">MRPDRHSVGGVAVVAARPSAPIIAATLRRNGIRDLTVLGSTALAADRPPPAVHTMEFDGAHDRWRLRSDDGTTTASVVILADADLDTRRITGVGADLHTLLTEGRVAHLGAAMHEMPNLFWTHSPAGAHWPHYPVQARAEYAARCVAAMCRTGGTRIQLRRAVQHESARRWAANPRLGRRLPRPDHRHFDTTVAADRAPACEYAGPAVLDAPGAELTVTVALNGHPDPIDGHYHWYGRLTAAEAELLPDPGRGVVSLRIAGGEPAAGRLQERDPWGNLRIAGIGRPPFPLADNGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2D7</accession>
    <name>A0A231H2D7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoserine phosphatase RsbU</fullName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsbU_1</name>
        <name evidence="3" type="ORF">B7C42_04890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43004">
        <property type="protein sequence ID" value="OXR43004"/>
        <property type="gene ID" value="B7C42_04890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014787">
        <property type="entry name" value="PSer_Pase_RsbU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08673">
        <property type="entry name" value="RsbU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="184"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="753" mass="80186" checksum="4B6071532D026F27" modified="2017-10-25" version="1">MSAVLAAFREAYANALRLHMDSPTQNTLAEGYELGRRALVEGVSILDLTEHHFRLLDEQGLIAGPGAQQLDGDAAQRAQAALEFLLQTLAALDVATRGFLDSTRSYELQRLRAEDLEGRDAFRTALVESLQDGFFVAADDGTITEVNSAFGALTGYGPDSVPYPLPHPWTDDESSTHYPALGTEAARFVMPARHRDGRRVWLAVSTSSLRNPEDDERLFVGTIRDVTAEHDAQARDQAVSLLATAVGAATTVAEVLSVGLEELRRAIGAETAVVSMWANRQTAPELYVSGPVAGGDAVSRQVIDARARALLDRTRMRPHRAMFAIPEGAASSEGIVAPLGETGDAALWVRFAAPRAISSGDWALFSLLVGHLSLAVQRARNFDQARSTSLTLQRAMLGPLELPPGFAVHYEPALPPLEIGGDWYDVVQLRDGTLGIVVGDCVGRGLSAAVVMGQLRTAAQALLLRGAGPAQLLAELDAVAARIPGAMCTTVCAAILDPARGLLRYSSAGHMPPVLASPGQTGRLLEGGRAVPLATFDTPNRPEATTAIEPGSTLVLFTDGLVEQRGIDIDIRFDQIADELSGAATHLPREVADAVLSRLRPEAGYDDDIAMVVYRQPPQPLHLDIPAEPARLSGVRRALTSWLSAAAVGHDLAADLVAAANEACTNSIEHAYAPDASGHVTLTATHVRGAVCLEIIDTGTWRPQPEDPGTRGRGLSMMRALADDVEIEHTETGTRVRMTAKLPLVTFSAASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2E3</accession>
    <name>A0A231H2E3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L,D-transpeptidase 1</fullName>
            <ecNumber evidence="7">2.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ldtA</name>
        <name evidence="7" type="ORF">B7C42_04902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43016">
        <property type="protein sequence ID" value="OXR43016"/>
        <property type="gene ID" value="B7C42_04902"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601732" evidence="4">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="125"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="26102" checksum="4CCE48402B8D3DFC" modified="2017-10-25" version="1">MRNMMRHVFLATVIAVLAAVTTGTAAAVLATPQSTSVASISPGNGAVVGIAHPITVRFTAPVTDRARAERSVHVGTQAGTFSWTSDRELVWNSTGYLPADARFTVTAGNARSEFRTDGGTSADADMSAHTFSVFIPGQAPRVMPASMGKPGRETPVGTFPVMEKDRTIIFDSRTIGIPLDDPEGYYLTGEFAERLTSGGVFVHSAPWSVGQQGNSNVSHGCINLAPADAEWYYDNVSVGDPVTTHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2P4</accession>
    <name>A0A231H2P4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Steroid C26-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.13.141</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.141" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777921.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43097">
        <property type="protein sequence ID" value="OXR43097"/>
        <property type="gene ID" value="B7C42_04983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="411" mass="46226" checksum="AD1CB7ED23663501" modified="2017-10-25" version="1">MSAPSLPSISHDFDFTDPDLLSQRLPVAEWAELRRTAPVWWVDQPNGVSGFDDGGYWVVSRLDDIKEISKNSEVFSTQENTAVIRFNGEITREEIEIQRAMLVNTDPPAHDKLRRIISRGFTPRAVESLRAALRERAERIVHEAKKTGGGDFVQQVACELPLQAIAELLGVPQEDRGKLFEWSNQMMGYDDPEYADSYKMANAQVMGYAWNLAEEKRKCPADDIVSQLLNADIEGEALGSEEFAWFVILLAVAGNETTRNATTHGMKAFVDNPAQWELYKAERPRTAPDEIVRWATPVIAFQRTALSDTEIGGQAIKKGQRVGLFYSSANFDEERFDKPFEFDIMRNPNPHVGFGGTGTHYCVGANLARLQLDLIFNAIADVMPNLREVSEPVRLRSGWLNGIKSWQVAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2T6</accession>
    <name>A0A231H2T6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acdA_4</name>
        <name evidence="3" type="ORF">B7C42_04587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43165">
        <property type="protein sequence ID" value="OXR43165"/>
        <property type="gene ID" value="B7C42_04587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="197"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="35780" checksum="30B18F52964C8263" modified="2017-10-25" version="1">MSAASSTTTRSATDTAEGRDMGLDAETQTVIAESLRELFAARNGRTSLAPLLAELGWAEVLAADPRAAVGLLFTEHGRALAGSRALDDVVLAELPELPDADLRRAVVYSSGTIDLPRDHERIDGIVLGPLDDVDEVVIPVAGAQGAPALFIVPVADIRASAAPLGGFDPAAGWTAIGGLALGDLVPTPAGRSWERAVAAGRRALSAEILGICDATMDLVTAHTTTRVQFNRPIGAFQAVRHRLAEAAVAIAGARSVLDAAWNAAAAPGGGAWAAKIAKVRAGRAQAELMRNAVQVFGALGLTREGDLHRYVTRAAALDALLGGHRLLTEAVGNAVLDGTEDDSAFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2U6</accession>
    <name>A0A231H2U6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fadJ_3</name>
        <name evidence="10" type="ORF">B7C42_04569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43147">
        <property type="protein sequence ID" value="OXR43147"/>
        <property type="gene ID" value="B7C42_04569"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="321"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="502"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="721" mass="76628" checksum="B488F1DD444C0CE7" modified="2017-10-25" version="1">MTQAQTIRWERGSDDIVVLTLDDPTASANTMNRAFFVSLTAVVDRLAAERDTLRGVVLTSAKKTFFAGGNLDDLIAATPDDAQYFTDFCNGIKHQLRRLETLGRPVVAAINGAALGGGLELALAAHHRIAAAKGVVIGLPEVGLGLLPAVGGVTRTVRILGVERALSEVLLTGTRFKPQKALELGLIHRVVATAEELVPAAKAWIEANPDAAQPWDTKGYTIPGGTPADPGLASRLPILTATLHSRSKGAPLPAPRAILAAAVEGAQVDFDSATSIETRYFIPLVTGQIAKNMIQSAFFDIQTVQGGASRPAGEPAFAATKVGILGAGMMGSALAYVCARAGLPVVLKDLTLESAQRGKTYAEKLEAKAVARGATTEAKSKELLGRILPTAEAGDLAGVDFVVEAVFEDVALKQRVFQAIQDIVEPDAVLGSNTSTLPISTLAEGVKRQQDFIGIHFFSPVDKMPLVEIITGKNTSQQTLAKVFDFTQQIGKVPIVVGDSRGFFTSRVIMTFLDEAVAAVGEGVTAALVEQAGAQAGYPAPPLQLMDELTLTLPRKIRQEKRAAIEAAGGRWSAHGSEAVIDSMIDEFDRKGRSTGSGFYDYDESGKRIGLWPGLRNAFGSGTRDIPIRDLQERMLFAEALETVRCFDEGVLTSVADANIGSLYGIGFPSWTGGVLQYINGYDGGVPGFVARARELAERYGDRFNPPESLQAKASRGEIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H354</accession>
    <name>A0A231H354_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009635.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43248">
        <property type="protein sequence ID" value="OXR43248"/>
        <property type="gene ID" value="B7C42_04670"/>
    </dbReference>
    <dbReference type="GeneID" id="66723446"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="79"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="44289" checksum="9B1CB6D63357EE7A" modified="2017-10-25" version="1">MPLQDHHQIVSVDDHLIEHPRVWQDRLPEKLKDRGPKIVEVDNKHVWHYDGDIFPTVGLNAVAGKPPEQWGLDPVRYEDMIPGCYDPAARIKDMDVDGVEAALCFPSFPGFGGGVFHRAKDKELALLAVKAWNDYHVDEWCATAPTRLIPMSLIPTWDPTLAAQEIRRTAAKGSRTITFPDSPVPLGLPSFHDKTYWEPVWDACEETGQVLSLHFGSGSYVPGFSFSGTKAIPGQVVLPDAPFAVAITIFSTNLMWSLTDLLFSGVLQRHPKLQFSLAEGGIGWIPYILERADFVWERHRHYQPIDFDTRPSDLYFKHFWGCFIDDQFGVENRHKAGIDRIMLEIDYPHSDSNWPNSRKRAAEVLADVPDHEVEMITETNARRMLNFPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3B6</accession>
    <name>A0A231H3B6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43302">
        <property type="protein sequence ID" value="OXR43302"/>
        <property type="gene ID" value="B7C42_04724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="16052" checksum="BAC1725D442154C4" modified="2017-10-25" version="1">MDHAELVAREQVRDLVATYAHSGDRMRLATLAGCFTEDGILEVKGLPAAVGRAAIIEMLTPDPGSESPAPRFIRHFVTNLRFDSIAPGRIEASSYFVVLTADGPDHWGRYRDVVVETGEVWLFAHRLVAVDAAAPGGWFAGRQPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3J3</accession>
    <name>A0A231H3J3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909271.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43336">
        <property type="protein sequence ID" value="OXR43336"/>
        <property type="gene ID" value="B7C42_04759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15573" checksum="DE0A9CCCE75B64B4" modified="2017-10-25" version="1">MIAALPLEAYPCRREISLIFADIDTIGHVNNVAIARFFEEGRVAVGRMIAELLGERVPLRMVLAHVEIDYLAEVMYPGEVQLGAGVHRVGRTSIEFRAGLFQHGRPVAVSRSVDVNTVEGRPGAVPLSGQYRTVAQKLLLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3N8</accession>
    <name>A0A231H3N8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">alkF</name>
        <name evidence="8" type="ORF">B7C42_04331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the rubredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779301.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43464">
        <property type="protein sequence ID" value="OXR43464"/>
        <property type="gene ID" value="B7C42_04331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="7189" checksum="B3303E10A5232964" modified="2017-10-25" version="1">MSRFRCPVCDYVYDESDGAPREGFPPGTAWSAIPEDWCCPDCGVREKPDFLAELATHDPTPTKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3V2</accession>
    <name>A0A231H3V2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase YpdF</fullName>
            <ecNumber evidence="6">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ypdF</name>
        <name evidence="6" type="ORF">B7C42_04408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43540">
        <property type="protein sequence ID" value="OXR43540"/>
        <property type="gene ID" value="B7C42_04408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="45"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="186"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="42962" checksum="1AD183820C144A7B" modified="2017-10-25" version="1">MGNTRSPPVAAVGAGDGVTASQHDSGSVAAMSADDGARRPDHAARRAGLRDLLVENGVDALLVTDLVNIRYLTGFTGSNAALLVHSWDGSQVGEDGERTVICTDGRYLTQVGEQVPDVRAEIARASARRLVELAGEWQIGRVGFESHVVTVDQHRGFVEQGSGLQFVAAPGLVEQLRTVKDDYEVEQLRTACAAADAALATLLERGGLRPGRTERQVARELEWLMFEHGADAIAFETIVAAGANSAVPHHRPTEAILAAGDFVKLDFGAVVGGYHSDMTRTLVLGEPTDWQREIYQLVYEAQQAGRAALKPGASCAAVDAAARSVIESAGHGDLFVHGLGHGVGLQIHEAPPVAKTATGTLLDGVAVTVEPGVYFPGRGGVRIEDTLVVRAGGPELLTHTTKDLTVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H490</accession>
    <name>A0A231H490_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43526">
        <property type="protein sequence ID" value="OXR43526"/>
        <property type="gene ID" value="B7C42_04394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="351" mass="35783" checksum="8C462ADC4F13A5BA" modified="2017-10-25" version="1">MTDSPQSAPRDTGEGGERRPESRPGQHPTGPVRPGAGPGEHPATQGRPEMTGAAGYPQFEGSGAPQYGAPQYGGAPGEQPQGAPGGVPPVAPPPGAHGQPGPTYGPPGSVPPGAYPPPADPAWGTPDNGMPPQGAPGYGAPPGYAGAPGLNIGRALGFAWDRFRANPIPWIAITLVGFVAYLMVTVVVNVTHMNSLMPVVLIGLLAAVVVWLLQAAMIRGALYETDGTPPDFASFFGFVNAGNVLITALLVFVAACVGAVLCIVPALVVGYLCMFSLHYVIDQDLDPFSAIKSSVQLVVSNFVPTLLLALTVAALTIVATALCGIGLLVVGPLTIIAVTYSYRMLTGGLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4R6</accession>
    <name>A0A231H4R6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinone reductase</fullName>
            <ecNumber evidence="2">1.3.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">menJ</name>
        <name evidence="2" type="ORF">B7C42_04089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43854">
        <property type="protein sequence ID" value="OXR43854"/>
        <property type="gene ID" value="B7C42_04089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="43890" checksum="83CBCA22D89EB20A" modified="2017-10-25" version="1">MLPEHVEVLVVGAGPAGSAAAAWAARAGREVLLTDAAVFPRDKTCGDGLTPRATAELEALGLGEWLRAHTVNRGLRMAGFGREALLPWPGGSFPTYGSAVPRTELDDKLRETAVKWGARMVDGVRVVAVARADDRITGVTVQTESGTREIRCDILIVADGVRSPVGKLLGRVWHRRFAYGVAARAYIRSARSDDEWITSHLELRDAEGGLVPGYGWVFPLGNGEVNIGVGSLATERRPSHIALKPLLQHYVSLRRPEWQFEGEARAVASALLPMGGAVSNIAGRNWVLVGDAAGCVNPLNGEGIDYGLEGGHLLSGLLGEPDLTTVWPDLLRARYGRTFSVARRIAALATHPRMVPTGGPPVMRSALLQRTAVRVMGNLVDEEDADLTARAWRTAGRASLRFDDPAPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4W5</accession>
    <name>A0A231H4W5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rpoB_2</name>
        <name evidence="6" type="synonym">rpoB</name>
        <name evidence="15" type="ORF">B7C42_04116</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43877">
        <property type="protein sequence ID" value="OXR43877"/>
        <property type="gene ID" value="B7C42_04116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="102"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="177"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="434"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="512"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="642"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR43877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1177" mass="130229" checksum="6EE41D860C67083E" modified="2017-10-25" version="1">MYVQAPGDAREVLEGRILAVSTQTKAGIPGAPKRVSFAKIREPLEVPDLLDLQTESFAWLVGAPDWRERAIARGDASPVGGLEEVLEELSPIEDFSGSMSLSFSDPRFEEVKASIEECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTDKGTFIINGTERVVVSQLVRSPGVYFDESIDKGTEKTLHSVRVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGMTTEEITERFGFSEIMLSTLEKDNTAGQDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGVNTGEPVIGSTLNREDIVATIEYLVRLHQGDKLMTVPGGVEVPVEVDDIDHFGNRRLRTVGELIQNQLRVGLSRMERVVRERMTTQDVEAITPQTLINIRPITAAIREFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVENGRVTDEVKYLTADEEDRHVRAQANSPVDADGNFLEERVLARRGNEEMEFVSPAEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLIRSESPLVGTGMELRAAVDAGDVVVNEKPGVVEEVSADYITVMHDDGTRKSYRMRKFARSNQGTCANQRPIVDEGQRVEHGQVLADGPCTENGEMALGKNLLVAIMPWEGHNYEDAIILSQRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDDDDLPPGVNELVRVYVAQKRKIQDGDKLAGRHGNKGVIGKILPKEDMPFMPDGTPVDIILNTHGVPRRMNIGQILETHLGWIAKAGWQVDGAESGNLPDWAKNLPEEMLGQESDTNIATPVFDGAQEDELTGLLGSTLPNRDGETMVDANGKSVLFDGRSGEPFPYPVAVGYMYILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDVVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIEMRDGDDEDLERAAANLGINLSRNEAATVDDLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4X0</accession>
    <name>A0A231H4X0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR43993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783865.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43993">
        <property type="protein sequence ID" value="OXR43993"/>
        <property type="gene ID" value="B7C42_03549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="10897" checksum="E7B52CC0F865D25E" modified="2017-10-25" version="1">MGSQFSVDLDHLDQIVSRLAGLAGFIADHLTDIEQRVTALQGTGWEGVAARAYDDAHREWVSGAQELVDGVREMSDSAKQAHAAYTRALELNGRMLRSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H538</accession>
    <name>A0A231H538_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor KstR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kstR2_6</name>
        <name evidence="6" type="ORF">B7C42_04186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43947">
        <property type="protein sequence ID" value="OXR43947"/>
        <property type="gene ID" value="B7C42_04186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="21583" checksum="9F7644F8A245D3A3" modified="2017-10-25" version="1">MSSSEAIAPTRREQLKAQRRQQLLEAGARLIADRGFPGVRLDDLGAAAGISGPAVYRHFPNKEALLVELLVGISTRLFEGGKAVAEQAESPRAALSGLIEFHLDFALGEPELIRIQDRDLESLPESARRQVRRLQRQYVEIWVGVLRGLHPDLDETAARVKAHATFGLINSTPHSASPTLAGRARPILREMAWAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5B5</accession>
    <name>A0A231H5B5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_03596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44040">
        <property type="protein sequence ID" value="OXR44040"/>
        <property type="gene ID" value="B7C42_03596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="23596" checksum="A79AF30C23416DD1" modified="2017-10-25" version="1">MAAVSDTVPELLRALDLTGVFANAMLGGAVARTFRFDPIGFAVLATASGLGGGIIRDTLLQRGTPVALVDYTYLLTALIGALIAFVFRFEGRLWDRLFPWVDSLALGCWAAVGAQKTLEVGLGWLPAVLLGTTTAVGGGVVRDIAVGRVPTIFGGNTLYATCALLASATLVIIWYSGHVTAGSIAATVVGAGLCLLARWRGWMLPEQMSWPDRLRYGRRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5C6</accession>
    <name>A0A231H5C6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase pkn1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pkn1_2</name>
        <name evidence="3" type="ORF">B7C42_03606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44050">
        <property type="protein sequence ID" value="OXR44050"/>
        <property type="gene ID" value="B7C42_03606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="35189" checksum="737036C2A17B0764" modified="2017-10-25" version="1">MPHRTDSGTHHACCAPSAGKSADPTEDIGAIGRPAGGDHGREFDPALVPVPGGTFTMGDESRWAYPGDGEGPCHPVTLEAFAVGRYAVTNADFAAFVADTGYRTDAEKYGWSFVFAGLLPPDMPPTRAVVNAPWWRQVEGADWAHPFGPASDVGALADHPVVHVSWEDARAFCTWSGTRLPTEAEWEYAARGGSTGPFPWGEGFEPDGQRRMNVFTGEFPRTAPGAHLGTMPVNAYAPNGFGLYNTTGNVWEWCSDYFSPDYYRHSPGANPRGPDLGRDRVMRGGSYLCHLSYCRRYRVSARQGSEPVSSTGNLGFRVVADAPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5E5</accession>
    <name>A0A231H5E5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent urate hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.113</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpxO_3</name>
        <name evidence="2" type="ORF">B7C42_03733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.113" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44173">
        <property type="protein sequence ID" value="OXR44173"/>
        <property type="gene ID" value="B7C42_03733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102099">
        <property type="term" value="F:FAD-dependent urate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="379" mass="40907" checksum="28EEC16A9BE65578" modified="2017-10-25" version="1">MRALRVIVVGGGIGGMAAAIALHRRGHDVQVWERAAAVGAAGSGLTLWPNGLRALDAIGVGAEVRSRAMADTEGGIRDRSGRWLTRTDTETVADRYGPVVAIHRADLFDILRTALGENRLRLGVTVTGVDNEEPAVRVLRAGGAESADLVVGADGLRSVVRTAVCPHARPPRYAGYTAWRMVTEPLADLRQGGQIWGSGEIFGIVPLADHRVYMFGAVNAAEGEHAPDGEFAEVRRRFGEWPDPVPRLLGAVSPDSVMRHDIYRLPDLPTFVRGRVALLGDAAHAMTPNMGQGANLALEDAVTLAALLDHGGIDDALRRYDALRRPRTRALAHRSRRIGTVAQWSWTPAVRARDTALRLMPGWAMPRAFARALDWTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5F9</accession>
    <name>A0A231H5F9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster insertion protein ErpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">erpA</name>
        <name evidence="2" type="ORF">B7C42_03614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500157.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44058">
        <property type="protein sequence ID" value="OXR44058"/>
        <property type="gene ID" value="B7C42_03614"/>
    </dbReference>
    <dbReference type="GeneID" id="66721710"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="12277" checksum="9EAAB55D48F839A0" modified="2017-10-25" version="1">MTVQNETTTHGVILTDAAASKAKALLDQEGRDDLALRIAVQPGGCAGLRYQLFFDDRTLDGDLTAEFGGVKLAVDRMSAPYVQGASIDFVDTIEKQGFTIDNPNATGSCACGDSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5J8</accession>
    <name>A0A231H5J8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="13" type="ORF">B7C42_03689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44131">
        <property type="protein sequence ID" value="OXR44131"/>
        <property type="gene ID" value="B7C42_03689"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="215"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="26"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR44131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="391" mass="40185" checksum="B5C3EA8384C0298D" modified="2017-10-25" version="1">MTTGESGGTTGSGQRTLSVIVAGGGTAGHIEPAMAVADALRRLDPSIRITALGTQRGLETTLIPERGYPLELIPPVPLPRKPTADLLRLPGRVRAAVARTRAVIDAVEADVIIGFGGYVSVPAYLAAGGGVLRRSRRVPLVVHEANVKAGIANKVGARRAVRVLAAVPNSGVHARGRADAEVVGIPVRASIATLDRAGLRAQAREHFGLPKQGPVLLVFGGSQGARRLNEAVSGAAAQLLAAGVSVLHAHGPKNTLDLDGIDTESGRDGAKYVAVPYLSRMDLAYAAADATVCRSGAMTVAEVSAVGLPAFYVPLPHGNGEQEFNARPIVAQGGGRIVADAEMTPKYVMDEVIALLTDPAALTNMSVAAAGAGHRDAADTVARIVLEVTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Y5</accession>
    <name>A0A231H5Y5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsA_2</name>
        <name evidence="3" type="ORF">B7C42_03809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44248">
        <property type="protein sequence ID" value="OXR44248"/>
        <property type="gene ID" value="B7C42_03809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="49"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="136"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="307"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="503" mass="55430" checksum="9EA89FFCA8E414B9" modified="2017-10-25" version="1">MSTTDHNPSGATQHMPTTVTSPQVAVNDIGSAEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPAEVVSVGDEVEALVLTKEDKEGRLILSKKRAQYERAWGTIEELKEKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLHQLQKGQVRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGMEVTVEVLDVDLDRERVSLSLKATQEDPWRQFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAVGDDAMVKVIDIDLERRRISLSLKQANEDYHAEFDPSKYGMADSYDEQGNYIFPEGFDPETNEWLEGFDKQREEWEGRYAEAERRHKMHTAQMEKMAADAAAEAANGGASGNYSSESGAQSSSSSSSEPAGGSLASDAQLAALREKLSGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H675</accession>
    <name>A0A231H675_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497439.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44404">
        <property type="protein sequence ID" value="OXR44404"/>
        <property type="gene ID" value="B7C42_03193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="8620" checksum="59A85469F36F6B3F" modified="2017-10-25" version="1">MGSNITVLRGLEPRATDQEIFAAAQEYVRKVGGLTGLSYVTKPAFDKAVAAVAAATTTLLAELPDHPVTAAAEPPLRATGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D6</accession>
    <name>A0A231H6D6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ybhR</name>
        <name evidence="10" type="ORF">B7C42_03888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500730.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44327">
        <property type="protein sequence ID" value="OXR44327"/>
        <property type="gene ID" value="B7C42_03888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004377">
        <property type="entry name" value="ABC_transpt_DrrB/DrrC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00025">
        <property type="entry name" value="Mtu_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="17"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="28189" checksum="62458D2E7E011A19" modified="2017-10-25" version="1">MTTTFAPPSRRPLRCYTATSARILRQLRADRRTVAMLLLVPTLLMTLLYFVYHETPTMPGVPSLFDRVGISMLGILPFIVMFLITAIAMQRERTSGTLERLMTTPLSKLDLLGGYGTAFSVAAAAQAGLACLISFWLLGLQAAGSAWLVLLIAVVDAVLGVALGLLASAFARTEFQAVQFMPLVVGPQFFLCGLLVPRDQLPRWLEIISDVLPLSYAVDALQEVSRHPGATAAMWRDLGIVAAFAAVALALGAATLRRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H707</accession>
    <name>A0A231H707_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">cobD</name>
        <name evidence="12" type="ORF">B7C42_02757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44803">
        <property type="protein sequence ID" value="OXR44803"/>
        <property type="gene ID" value="B7C42_02757"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR44803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="34470" checksum="9650C3714A78AAF8" modified="2017-10-25" version="1">MALFGSAAAALESPWYRDTRAAGVVHEIVLVSGVVALGAGAEIAGRRSGALRGRRAVASAGADRRKGGGAAGRTRDGCTDPRTAAGRSGLRAGLGTVVITAVGTWIALGGTTLARTGRDMADRLEAGELSGARELLPSLCGRDPEVLDADGLARAAVESIAENTSDATVAPLVWGAIAGVPGVLGYRAINTLDAMIGYRNERYRNFGWAAARVDDLANLLPARVSGALTVALAPLVGGRPGDAWRAWRRDAGAHPSPNAGVAEATMAGALGVALGGRTEYRHGIEMRPVLGSGRTPQVHDLRRAVRLSNGVQLAAAVAAAAYALGRRRSVRAELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7G2</accession>
    <name>A0A231H7G2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metallo-hydrolase</fullName>
            <ecNumber evidence="3">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44963">
        <property type="protein sequence ID" value="OXR44963"/>
        <property type="gene ID" value="B7C42_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="206" mass="22283" checksum="3061952F3C6F03F9" modified="2017-10-25" version="1">MKIDRVVTSGKFELDGGSWDVDNNVWVVGDDREAVVIDAAHQAEPIVAAVGDRTVRAIICTHAHNDHINVATELAAALRAPILLHPADEVLWSALYPDTRYEPLHDRERIPLADSDIEVLHTPGHSPGAVSLYLASEKTVFTGDTLFQGGPGATGRSFSSFPTIIESIRTRLLHLPADTTVLTGHGDSTTIGAEAPHLPEWIKRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7K0</accession>
    <name>A0A231H7K0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0311 protein B7C42_02783</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0311 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777147.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44829">
        <property type="protein sequence ID" value="OXR44829"/>
        <property type="gene ID" value="B7C42_02783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00775">
        <property type="entry name" value="UPF0311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="PTHR37315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="16821" checksum="CD231B38E4F75827" modified="2017-10-25" version="1">MSAPAVPGLEVAFQVEARLGPPEDHGVTRAGHRRVVPIVGGRVRGLFDAEILPGGADWQVIRPDGAIEIDTRYSARTADGAHIYLRTSGIRSGAPEVLNALLRGDPVDPSDYYFRLVVRLETSDPRLAELEQSLFVASAIREANTVRYIAYRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7N5</accession>
    <name>A0A231H7N5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44767">
        <property type="protein sequence ID" value="OXR44767"/>
        <property type="gene ID" value="B7C42_02721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="34471" checksum="B3FF165ED718D775" modified="2017-10-25" version="1">MTASVARAERTEHELGPRKPIEPGTRMWDEVGLITFSLTAGSAFLLQTMEPTISAVVDEHSTFRTDPMGRAMRSLAAVMTWTYGGDEAVAEADRLRHMHASLNTVDPQGKRHSALASGPWAWVLHTGTYAFNEGSKYFSRTPLTYAEKEQYYQEVLQLLRMFSVAPKEIPPTYAEFEVFFADTVENHLVATDTARDYLKTIRHVAPPTSLPEPLVPLWKLAASPLGRMQYFCTVGTTPEPARRKLGLTWTARDERNLRILGWVLARLVPLLPERIRYFPIAYEARKLERDRARLRKVLDLRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H895</accession>
    <name>A0A231H895_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-(S)-hydroxypropyl-CoM dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.269</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xecE_1</name>
        <name evidence="2" type="ORF">B7C42_03048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.269" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45091">
        <property type="protein sequence ID" value="OXR45091"/>
        <property type="gene ID" value="B7C42_03048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050575">
        <property type="term" value="F:2-(S)-hydroxypropyl-CoM dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="29043" checksum="77EE64FE1E6E439C" modified="2017-10-25" version="1">MSTRLPGTVVAVTGGARGIGYSIAEHLRDAGARVALGDIDADAVAEAGSRLGAAAALALDVTDPGSFADFLAAVETEAGPVGVLINNAGIMPVGRFTDESDTITRRILEVNVLGVMNGTKAALPQMLSRGRGHIVNIASLAGENPTPGMATYCASKQAVLGFTEAMRLECRGSGVRFSAVLPTFTRTELIAGTKAPMGLLAEPEDVARAVVRLIARPRRRVTVTRLAGVAMAFNKLTPRAFGEFTARRMGVHRIFTDEVDRAARAAYDRRVGNTPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8V5</accession>
    <name>A0A231H8V5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776749.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45261">
        <property type="protein sequence ID" value="OXR45261"/>
        <property type="gene ID" value="B7C42_02386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="81"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="182" mass="20787" checksum="66CA1863E7C1D56C" modified="2017-10-25" version="1">MGYPEELLAPDEQLLLHRHPHWKMLFLPALTFILATALAGFLSGLAWRNTEGTTRNIVLIAIVVVWALLVVWRCLSQVIRWKSTHFIITDRRVLVREGVLTHTGIDIPMNRISSVQFRHGLSDRLLGTGTLIIDAASGDPLEYDDIPNVQKVHSLLYHQVFDNPHGDPGHDQYQDPRYGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Y2</accession>
    <name>A0A231H8Y2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45147">
        <property type="protein sequence ID" value="OXR45147"/>
        <property type="gene ID" value="B7C42_03104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="16025" checksum="212FE650D64298DA" modified="2017-10-25" version="1">MRVRAFKRVALPIDVVWAALADHEGMSDWSPGVTVTLERDGDLERNGVGAVRCVRGPGIVLREEVTGYERDRWLAYRLVSGLPLRGYRGEVFLSRCDEETAITWTLMCENRSALVRFGLGLYANIFINALVRTARRGTLVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9I7</accession>
    <name>A0A231H9I7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45683">
        <property type="protein sequence ID" value="OXR45683"/>
        <property type="gene ID" value="B7C42_01975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025325">
        <property type="entry name" value="DUF4231"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14015">
        <property type="entry name" value="DUF4231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15793" checksum="441CC2AB49F63FFE" modified="2017-10-25" version="1">MVEDSAPADPVWQRLEDQSRWYSAKSRQAQHAHKRVKFGQIAVGATVPVLAAVSGVPGWLTAAVAASVVVAEGAQQLFQWQNNWLSYRTTAESLKRERFLYIAEAGPYSGADRRRVLAERIENIAAGEAVEWSTRHMPSDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9S1</accession>
    <name>A0A231H9S1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monoterpene epsilon-lactone hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlhB_1</name>
        <name evidence="2" type="ORF">B7C42_01872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.83" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45580">
        <property type="protein sequence ID" value="OXR45580"/>
        <property type="gene ID" value="B7C42_01872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="33341" checksum="97FDC4E6F237F50A" modified="2017-10-25" version="1">MIRENIRRIPGKALYYAIRMVPMDLGDPAFVTKMIAKDRATGPKRPSRRGLAKLDFWEDTEAGLRTFHARRKGAPATPLRLLFLHGGAFVMNFQTTQWTIPIGLLERVDAEVVAPVYPLGPEADWKETTTAIERHYLALAEAHGAENIIVFGDSAGASLTLLLAHALRDAGLPLPKALVLFSPALDLTGTDPGQKALAPRDPMLSLGVFKEIERRWLKGLPPHDPRVSALFASHADLPPTIIFSGDREILDSDAHRLKAANPSVDHRHYPGMVHVWPNFPIPEGRQALDEAASFIHLHRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA65</accession>
    <name>A0A231HA65_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rip3</name>
        <name evidence="13" type="ORF">B7C42_02052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45760">
        <property type="protein sequence ID" value="OXR45760"/>
        <property type="gene ID" value="B7C42_02052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="249"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="315"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR45760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="388" mass="40943" checksum="A6F71B67AAD5CBA9" modified="2017-10-25" version="1">MLHETIPLGRVAGIRVGAHWSVLVTVALFVWLLGVQLRGSGSPAFTWSVAALAAVTLFASLTAHELAHSIVARRHRVRVERIVLWLLGGASELGDEPPDARSDFRIAIAGPATSLVLGGLFAVVAVAVDSGRPDSAVTAALAWLAVTNIALGLFNLLPGAPLDGGRVVRALVWWRTGDRLRATTVAARGGRLLGTVLVVLGAVDIIVFRQFGGLWLMLLGWFLQTAANSELAAAGLRHRLGDARVRDVMTENPMAVPAEWTITQLLNSSAPRTGHRVFPVVDALGHPIGVVAWSDLTATAVPARETTQLRSVARPLRAVAIVGRDDLLADVATRVVLRPKLDAVAVVDPSGRLTGVITATDLVTACDRSALGLPVGRPSHQETAPDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA77</accession>
    <name>A0A231HA77_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative NAD(P)H nitroreductase acg</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acg_2</name>
        <name evidence="1" type="ORF">B7C42_02050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45758">
        <property type="protein sequence ID" value="OXR45758"/>
        <property type="gene ID" value="B7C42_02050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="36918" checksum="309E1C6AF16BAF90" modified="2017-10-25" version="1">MNTVPSRDVVETAVRMAGRAPSLHNSQPWRWMFDGAQLRLFSVHERMLPTTDDTGRQLVISCGVVLDHLCAAMAAHGWRTIVATFPNPNDRTHLADVRFEPSPYITDGDRERAGAMARRYTDRLPFDEPEGWEPFETVLRTVFDPEDTIVDVLPDDSRAELARASELTASVRRYDADYHAELHWWTGHVVARTGIPREALVSEEERGRVDVGRRLPTVTGEPRRTEVRTDRSKILVLSTYGDSPAEWLACGRVLSTVLLECTLAGYATCPLTHLTEVPRSRSVVTRLLGRNAFPQVLIRVGRAPQNQPHPDPTPRLPLHEILRVTDGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAN5</accession>
    <name>A0A231HAN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acryloyl-CoA reductase (NADH)</fullName>
            <ecNumber evidence="3">1.3.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acrC_2</name>
        <name evidence="3" type="ORF">B7C42_02088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.95" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782524.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45796">
        <property type="protein sequence ID" value="OXR45796"/>
        <property type="gene ID" value="B7C42_02088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="167"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="34221" checksum="8CBF71C3F59DDFCB" modified="2017-10-25" version="1">MNIDLSREAADYGREASRAFAGAGGDRLIQDAEADPTRRADIVAPVLAGLGAWELDPRRDRDDLEAAAALCRSAGYWALPYPLAERLARPIDAQADGLVVVTESRARGAVADLDLRWAAVTVEGKLFQARTLPDGAPPRTSAFVTPLVLTSVGAAGHADAALVLTLNCWTLLGMLDRALDLTRSHVLMRTQFGQPLAKFQGVQFQLTDAEVERSGLDVLATYALWSVRCGGEDALGDALAARVAALDAAETVFRVAHQLHGAIGFCDESPLSWLSRYSLPLRRLPWASSGTRDRLTRHLGTRGLPGPFDGGEAVDATWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAZ7</accession>
    <name>A0A231HAZ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46050">
        <property type="protein sequence ID" value="OXR46050"/>
        <property type="gene ID" value="B7C42_01013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="125" mass="13770" checksum="0119608C418111AD" modified="2017-10-25" version="1">MDSAAARNLSASEDSSASEEIAAVVEGASGAVVEVAPEGGVVDGLTRRELEILDFERKWWKYAGAKEEAIRDLFAMSATRYYQVLNTVVDKPEALAADPMLVKRLRRLRASRQKSRAARRLGFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBC2</accession>
    <name>A0A231HBC2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46243">
        <property type="protein sequence ID" value="OXR46243"/>
        <property type="gene ID" value="B7C42_01209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="399" mass="42862" checksum="0187366EF62B8E64" modified="2017-10-25" version="1">MTATPEIATSSTDVPVVPASRPAPAVPGIRKFVPALEGLRGLAALGVVLTHVAFQTGAAGTPVIGRVWERFDMAVAVFFGLSGFLLWRPHAAAARGLGTAPRAGRYLLHRAARILPAYWVVVCVALTLLPSAAHSAGLRVWGANLTLVQVFVPLTLTDGLTQMWSLSVEVAFYLVLPLLAWALAGLRGTAARHRVFAVTAIGVLCLGWNFLPVPTPDAIHADNWLPGYLPWFAAGMVLAELAEILGARSRDGDAAPRWQRWLGDRRLMWSVAAAAFALSATELAGPAGLARAAAWQYAMKMGLGALIGFGLLAPLVLGVARHRFLESRLALTIGRWSYGIFIWHLVVLAMMFPIFGFIPFNGGFLHVLALTVAFTIPLAAASYALVEEPVRQWVKRRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBK9</accession>
    <name>A0A231HBK9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_01236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46270">
        <property type="protein sequence ID" value="OXR46270"/>
        <property type="gene ID" value="B7C42_01236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="429" mass="44679" checksum="E03DE22188CBC27A" modified="2017-10-25" version="1">MSADSKTSGNPAEPAPAGVASAASGRTASVRGRERTAADSVHPLVRQGAEWCWRLLIILVAVLAVAYLAHKLTTVVIPVAIALLAAALLSPLVDLLQRLGIPRGIGVFVALVGSLGLLAGIFTFVIEQFITGVPQLTDEFKTSIHTVQDWLINGPLHLSNDQIRNGGNTIIKTLEANQDSLTSGALTTAAAVGEFLTGAFLTLFILIFFLYGGDQIWNFVTRIVPTPQRERVRTAGRLGFGTLIGFVRATVVVAAVDAIGIGAGLAILSVPLALPLASLVFIGAFIPIVGSLLAGFIAVFLALMTKGFVTALIVLGITVAVMQLEGHVLQPLLLGRAVRIHPLAVVLAITAGVVLAGIAGGLLAVPFVAVMNTAIRSLLVGSPEELYQELNTGEPGEPMFHADPDRPDPGRYRPAESRSDAGGGDADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBR0</accession>
    <name>A0A231HBR0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trehalose import ATP-binding protein SugC</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sugC</name>
        <name evidence="6" type="ORF">B7C42_01277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46311">
        <property type="protein sequence ID" value="OXR46311"/>
        <property type="gene ID" value="B7C42_01277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="359" mass="39014" checksum="D67CAD1372FDBA4C" modified="2017-10-25" version="1">MATVTFDHATRLYPGGTKPAVDKLDLEIADGEFLVLVGPSGCGKSTSLRMLAGLEEVDDGRILIGDRDVTDAEPKQRDIAMVFQNYALYPHMTVAENMGFALKMAKVGKAERNQRVLEAAKLLDLQDFLDRKPKALSGGQRQRVAMGRAIVRQPQVFLMDEPLSNLDAKLRVQTRTQIAQLQRRLGTTTVYVTHDQVEAMTMGDRVAVLKDGLLQQCASPRDLYRDPANLFVAGFMGSPAMNLFTLPVSDGSVILGGHSIALPRAVADAAGESVVVGIRPEHFDLAGGSNGIAMEIDVVEELGSDAYIYGRTLGEAGGDQTIVARADWRNPPQKGDKLTLTTDAEHTYFFDPADGRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBR3</accession>
    <name>A0A231HBR3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ubiX</name>
        <name evidence="7" type="ORF">B7C42_01254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46288">
        <property type="protein sequence ID" value="OXR46288"/>
        <property type="gene ID" value="B7C42_01254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="20613" checksum="C0F17979AEE75C13" modified="2017-10-25" version="1">MSQGVDEQPTRLVVGISGATGIAYGVRALEFARKAGVQTHLVVTPAGQQTRQYETELSAKDLAAMADVVYRPSDIGAAIASGSFRTAGMLVAPCSIRTLSAIAYSNGDNLLTRAADVTLKERRRLVLLVRETPLTLGHLRAMTAVTEMGGIVMPPVPAFYLRPGSIDELVDHTVARALDLLGIDVPDMPRWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBW9</accession>
    <name>A0A231HBW9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ponA1_1</name>
        <name evidence="12" type="ORF">B7C42_01288</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46322">
        <property type="protein sequence ID" value="OXR46322"/>
        <property type="gene ID" value="B7C42_01288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="108"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="374"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="726"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR46322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="765" mass="80943" checksum="3072B070C62DD6C6" modified="2017-10-25" version="1">MSSTRKPRRGRPETAPYASIAGWKQLDGTSRPNSGRPRRREKPAGAGDRPPRTRGQRIRRLLLALFLIFVAIPSLLLVLAYWSAEIPDPSAVQTNQIATVAAADGTTVLAKIVPPEGNRTPVPLSEVPQTMRDAMLSAEDRDFYRNPGFSASAFLRAARDNLLGHDDAGGGSTITQQYVKNAFLSSERTLSRKMRELVISAKMARQWSKDDILAAYLNTIYYGRDAYGIAAAARAYFDKPVSQLTLAEGAVLAAVVRTPSILDPETHLDQLKTRWNYVLDGMVGMGVLPLGERDKVQFPTIAPPPKPDDDAARGPAGLIRTQVLKELRAAGIGDQEINTGALQITTTIDAKAQQAAVDAVHRTLDGQPPQLRSAVVSIDPRSGAIRAYYGGEDGVGYDFAQAPLQTGSSFKTFAMLAALQQGFTLTSQLDSSPVVVNGVRVTNVEGESCGTCSLAEAYKRSLNTSFIRLTQAIGPRSVTDAAHQAGIPLQIPGVPGTSLSEPDGQPAPTVVLGVYSVRPVDMASAYATIAASGSYHQPYFVQRVVAGDGRVLLDRGAPGTAQLPPPQQRFPRGITDTATKAMQPIPGYSNGHNLAGRPSAAKTGTTQLGDTGENKDAWMIGFTPSLSTAVWVGTDQPEPIRTAGGGLIYGSGLPSDIWKRTMDGALAGTPVEQFANPDPSAAAGPFAAPPPPNSAGPFAEPEQPPAAPPQPTGNAPFDILQPPSQSEQQQPPPVIVIPPAPPPPPPPPPPRQVEIFPGLTVPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBY5</accession>
    <name>A0A231HBY5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gyrB</name>
        <name evidence="13" type="ORF">B7C42_01419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781826.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46453">
        <property type="protein sequence ID" value="OXR46453"/>
        <property type="gene ID" value="B7C42_01419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="460"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR46453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="682" mass="74862" checksum="A1BF1893423D8FE1" modified="2017-10-25" version="1">MAANDSNASGSSKAKAGNKDYGASNITVLEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNSVDEAMAGYATRVDVTLLADGGVEVVDDGRGIPVAMHATGVPTIEVVMTQLHAGGKFDSDAYAVSGGLHGVGISVVNALSSRMVTEIDRDGFHWSQEYKDAKPGKLVKGEPTDRTGTTQRFWADPDVFETTTYNFETISRRLQEMAFLNKGLTITLTDERVSEAEVTDEVVSETAEAPKHDEGTATPPEPKVKTRTYHYPGGLEDFVKHINRTKQAIHNTVVSFTSKGTGHELEVAMQWNSGYSESVHTFANTINTHEGGTHEEGFRAALTTVVNKYAKDKKLLKEKDGNLTGDDIREGLAAIVSVKVSEPQFEGQTKTKLGNTEVKSFVQRTCNEHLAHWFEANPADAKTIVQKAVSSAQARVAARKARELVRRKSATDLGGLPGKLADCRSKDPSKSEIYIVEGDSAGGSAKSGRDSMYQAILPLRGKIINVEKARIDKVLKNNEVQSIITAFGTGIHDEFDISKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLVEHGHVYLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGLAAGKKINKDDGVQRYKGLGEMNAKELWETTMDPSVRVLRQVTLDDAAAADELFSVLMGEDVEARRSFITRNAKDVRFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBZ6</accession>
    <name>A0A231HBZ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2 transport protein TqsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tqsA</name>
        <name evidence="7" type="ORF">B7C42_01433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46464">
        <property type="protein sequence ID" value="OXR46464"/>
        <property type="gene ID" value="B7C42_01433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="37024" checksum="52366AB144DD2538" modified="2017-10-25" version="1">MLSVAAAVVAVLGMKAFAGVLGPTFLALMLTMAVQPVQTWVQRRGWRPWIGMVAALILVVLILLVLLGALVLSIAQLASELPKYSDKLDDMLNGVRDTLADLGVDTEQIHNALNGLDVGKVVDVLSVALSNALGIFSNLFFVLALLLFMAIDGMMIDRKLVVVAKARPEIAYALGVFASGTRKYLVVSTVFGLIVAVFDGGALWLMGVPLPLLWALLSFITNYIPNIGFVIGLIPPALLALLDSGPVLMVWVIVVCSVINFVIQSIIQPKFVGDAVGLSVTVTFLSLVFWSWVLGALGALLAIPLTLLMKALLLDIDPTTRWVGVLIQDRAPDPDEQPAPVPDEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC42</accession>
    <name>A0A231HC42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-chlorobenzoyl coenzyme A dehalogenase-1</fullName>
            <ecNumber evidence="2">3.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcbB1_1</name>
        <name evidence="2" type="ORF">B7C42_01358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.7" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46392">
        <property type="protein sequence ID" value="OXR46392"/>
        <property type="gene ID" value="B7C42_01358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018787">
        <property type="term" value="F:4-chlorobenzoyl-CoA dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="27133" checksum="6CFDA8247D6F0D3D" modified="2017-10-25" version="1">MSEYETITFERTGPVARITLNRPKAANGIDHVLGRELADIAGQCVDDPALKVVVLTGAGRFFSAGGDLKAMAAQGGGAGHYVKGLADDLHEALSSFARMDALLVVAVNGVAAGAGFSLAMAGDLVLAGESAAFTMAYTRAGLSPDGGASYYLPRLIGLRRTQELMFTNRTLTAAEALDWNLVHRVVPDAELAAAVDELVAEFAAGPRHSNASVKKLLLVSSSHTLEEQTAREAAFISACADSPDGTEGIAAFLGKRAPAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCG7</accession>
    <name>A0A231HCG7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46644">
        <property type="protein sequence ID" value="OXR46644"/>
        <property type="gene ID" value="B7C42_01618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7291" checksum="EC780E036D763D26" modified="2017-10-25" version="1">MITDSLAAVWFGGFTLGAGLTALGAAVVLFVSALRMRNHIEPELVAEPDDITDEDQAAELLPEWNSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCQ7</accession>
    <name>A0A231HCQ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46694">
        <property type="protein sequence ID" value="OXR46694"/>
        <property type="gene ID" value="B7C42_01669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="6936" checksum="FC97F8E098DE0FE7" modified="2017-10-25" version="1">MSERPYLGYLHDSDGVHLIGPDGLRDIDDAAAELTEDETPALDVPTIDVDPTSVTDIETGPAELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDA4</accession>
    <name>A0A231HDA4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46728">
        <property type="protein sequence ID" value="OXR46728"/>
        <property type="gene ID" value="B7C42_01705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17332" checksum="6D998C436431BE96" modified="2017-10-25" version="1">MHISARIDYAVRILLEIARAQPNSVKAETIATAQDISPKILESIAAQLRRADLVISRRGPDGGYRLARTAGEISIADVIRAVEGPLASVRGQRPEDVAYSGVAEPLQRVWIALRVNIRAVLEQVSIADIATDELPDFVADLVSDPGAWTRRPAPAPPGVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDB9</accession>
    <name>A0A231HDB9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoadipyl-CoA thiolase</fullName>
            <ecNumber evidence="4">2.3.1.174</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pcaF_1</name>
        <name evidence="4" type="ORF">B7C42_00069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46953">
        <property type="protein sequence ID" value="OXR46953"/>
        <property type="gene ID" value="B7C42_00069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="245"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="42405" checksum="95234741CC16E0DF" modified="2017-10-25" version="1">MPAHGICDRVAIIGMGCTNFGEHWDRSADDMLIEAVTSTTASAGVALADVDAFWLGTYMSGVSGLTLSRPLRLRDKPVSRVENMCATGSEALRNACYAVASGAYDMAMAVGVEKLKDSGFSGLLRHSIPSDGTGGTLGTTTAPANFSLLGPAYAEKYGVDSGELKNVLTRIAWKNHHNGARNSRAQFRKEVSTETISRSPLVAGQLGVFDCSGVSDGSAAAIVVRAEDAHKYTDKPLYVKALSFVSGAADGNVDPAYDFTSFPEVVSSARNAYKEAGIRDPRAEIAMAEVHDCFTVTELVLMEDLGFAERGTAWKAVLDGAFDLDGDLPVNPDGGLKAFGHPVGASGLRMLFECWLQLRGEAPQDRRIGTTAAGKTIGLTHNLGGGPGECVSFVSLVGTEPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDJ5</accession>
    <name>A0A231HDJ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase FadD13</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46991">
        <property type="protein sequence ID" value="OXR46991"/>
        <property type="gene ID" value="B7C42_00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding_C" evidence="1">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="102" mass="11292" checksum="43B9973B16205B9A" modified="2017-10-25" version="1">MIITGGENVYPAEVEEALFDHPAVAEVAVIGTPDEKWGEAICAVVVPRPGATVDLEELRSHAAERIGRYKLPRRLELLNCLPRNAAGKVLKTELRRRYNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDN9</accession>
    <name>A0A231HDN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxyacetophenone monooxygenase</fullName>
            <ecNumber evidence="1">1.14.13.84</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hapE</name>
        <name evidence="1" type="ORF">B7C42_00047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.84" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46932">
        <property type="protein sequence ID" value="OXR46932"/>
        <property type="gene ID" value="B7C42_00047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033767">
        <property type="term" value="F:4-hydroxyacetophenone monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="646" mass="72275" checksum="DB2C8EC87A8D356D" modified="2017-10-25" version="1">MPSMTNPEHPIDEARLKEAVQAANLPSLTMVLFQLTGDQRWLEEPYRPARSRGLGPNDSGGFAPEIAEEIRSCAVSALVAWSRGVPAAMPNPGPELLREMLTICMGEEIPAEYERVMREEMGFVPVPKPQPVQAGDFSVLIIGAGISGMIAAVRLRELDIPFVILERNPEVGGVWLTNTYPGAGVDTPSYLYSFSFFQRNWSTHFGKRDEMASYLADAADHFDLRRDIVFGVEVESATYDETAQRWTVAARDHAGTMREYSANAVISAVGLFNTPKLPDIPGIDTFRGPIFHTAEWPDGLDLTGKKVAVVGTGASAMQVVPAIADKVERLTVFQRSPQWIGPSEEYFAPVPEDVHWLMENVPNYHAWYRFRLAWVFNDRVHATLQIDPEWEHPDRSLNAVNDGHRRYFTRYLTEQLADRPDLIEKCLPKYPPFGKRMLLDNGWFAALKKDNVELITAGVSRITETGVITSAGREVDADVVVLSTGFEASRYLQSMEVFGRGGRSLRDIWGDDDATAYLGITMPGFPNLFFMYGPNTNSGAGGSYFFIGESQGRYIIEVIERMVREGLGAVECRPEPHDRWVREVDAAHAHMVWSHPGMSTYYRNSRGRVVTNSPYRVVDYWLMTHDPDPADFVIERAKASVAPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDU9</accession>
    <name>A0A231HDU9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA:oxalate CoA-transferase</fullName>
            <ecNumber evidence="1">2.8.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uctC_1</name>
        <name evidence="1" type="ORF">B7C42_00158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.19" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47039">
        <property type="protein sequence ID" value="OXR47039"/>
        <property type="gene ID" value="B7C42_00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="759" mass="81026" checksum="CD4C1D0C95F70395" modified="2017-10-25" version="1">MSGERPCADLTVVEIAVGVSDLGLGLAGGLPGMLLADLGASVIRVVGEAVPIDTDVPWGRVWHRDKRIVTTTGVAEISALLRTADVALVHGPEELVEARGLGFRDCAATNPALVYGRCRPSRTEAGTVEDFGLLVEARAGFCTQLPGHRRGPIFPEVRASGMGAAFLLLTSVFALLRRRVGTGTGGWSETSLYDGMLATLGCMIGRSERAAPEVESYWEHGSTFPNFLYRCADGELLQVWFGGKGMYQAVIEVLGDEPSRDGYYTDQTTGKLRARAQRWTSFFATRPRAVWVERLRAAGVACEPVLGPGEVLRDPHSAETGVAVTRSEHGHEDLMIGSPFEIHPLWPAPDAPVAARTRSAARLFEGLRVVDFSAFVAGPLAAEVLADLGADVIKVEPPGGEAMRAAAYAVAACQRGKRSLALDINAPDARPVVEKLLASADVVLHNFRVGVAERLGIDADTVARLNPNAVYCHASAFGATGPRAAYPGNDALMQALTGVERAIGGAGNEPLAATWIPIDMAGGWVAAAGIALGLYARATQRRGQQVITSLLGAGMLMHCGVFVRDGELVAGPALDERQTGYGPGYRIYEGADGEWFALVVADPESWWKLDEFVADCGGSGLGDYVPLRNGHDDSAARAAEANLESTFATAPAAEWVRRLRELGIPAELIEPMNRNRFRHAVLDDPVNRQLGRVVGYRTADWGYFEQIGPLLRTGPDVIGGPRLMIPGVGEHTTEVLSELGFDDARVDELLATKVARQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEU9</accession>
    <name>A0A231HEU9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47409">
        <property type="protein sequence ID" value="OXR47409"/>
        <property type="gene ID" value="B7C42_00532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008691">
        <property type="entry name" value="LpqH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05481">
        <property type="entry name" value="Myco_19_kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012691982" evidence="1">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="17066" checksum="D1A62EC02DC661A8" modified="2017-10-25" version="1">MRTKQIRIAAATLAAAGLTLALAACGDDSTTAAPASTTAAPATQAPSGGQSAALVDGKALSANFDTTCAQRGGTLALALTDAANPTFGRLSVSATLTAQGGTVQAVAIGGSKGGASGMPYAVGFGNGQPGGSATVSKDGKTYKITGEGVAAPDMTNPMAGPATAKFELTFACPTIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF47</accession>
    <name>A0A231HF47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ferrous iron permease EfeU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">efeU</name>
        <name evidence="11" type="ORF">B7C42_00695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EfeM/EfeO family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47570">
        <property type="protein sequence ID" value="OXR47570"/>
        <property type="gene ID" value="B7C42_00695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14656">
        <property type="entry name" value="Imelysin-like_EfeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018976">
        <property type="entry name" value="Imelysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034981">
        <property type="entry name" value="Imelysin-like_EfeO/Algp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038352">
        <property type="entry name" value="Imelysin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09375">
        <property type="entry name" value="Peptidase_M75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M75" evidence="10">
        <location>
            <begin position="510"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR47570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="752" mass="77750" checksum="292133B12E2CE00E" modified="2017-10-25" version="1">MQDWTCGIGMPYLWTVSWAEAVPNLLICLREGLEAGLVVTILLAAVRKTSTPQRPVSATPVWLGLLGAVSVAASFAAVLTYSTSVLSNSGQEIVGGTLSVIAVGLVTAMVFWMRRTAASLSGQLRGEVARATAIGAGALAITAFMAVGREGLESTLFVWTAVKASGTTVAPLAGAALGFAAAVVLCWLLYRQSVKLNLGVFFNRTALALIVIAAGVLSYGLGDLQDAGILPGRHWVAFDLSAHIDPNSWWVSIITGITELTPRMTVLQVVAWLVYLAVVIPLFIRAGRRAPAKAPAKRPEQSAPATTAGTAAAAAESEATGSNASSKDAGTTPASAAAPAPLAASTVAHDGSEHTPDWWERIAGPRPLLVGAVLVVVPAVAAGVAIALLPSSGSGKAQAVSVTDGSCASEWKSGRAGTQTFEVQNKTSKAGEINLVNSGGAVVGEIETIGPATTANLTATLSSGTYTMQCLMSGKPVTSSAAVQVSGEAGETPPAVKRVTEDDLRGPNDAYQAYAAGVLTRLSGAVTAIGNDLRGGNIAAAQADWLNAQLDWERVGASYNSFGDAGTAVSGLPDGLPGGVNDPGFTGLHRLEYGLWHGQRPDQLLPVVDRLGGDIANIRKNLGGDDLAGDPKNLPLRAHEILEDALRDHVSGIDDQGAGAAYPMTLADIDVTRAVLDQLGPLIDPRAPQLRTTLRTRLDELQAALLATQNHGQWQSPDRIPPAARQAVNARLGAALEELAKVPRLLEVPISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG42</accession>
    <name>A0A231HG42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47697">
        <property type="protein sequence ID" value="OXR47697"/>
        <property type="gene ID" value="B7C42_00822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="14321" checksum="8DF501922CBFEA92" modified="2017-10-25" version="1">MTTDVRGNGWRRVGPAAVWVGVAVAGSFTRPFSIAATVLVAGVAVVAAVRAVRLGTRRMSFTPPVRRAVVVWSTLLAAVLAWELYAWLSQPAPLVPDPAHPSLSTLLSPALEGGPGRFIGWLVWLGAGWWLVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGL5</accession>
    <name>A0A231HGL5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bphB_2</name>
        <name evidence="1" type="ORF">B7C42_00960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.56" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779655.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47835">
        <property type="protein sequence ID" value="OXR47835"/>
        <property type="gene ID" value="B7C42_00960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018509">
        <property type="term" value="F:cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="28018" checksum="9A98C0F23B73E5AB" modified="2017-10-25" version="1">MAILNDKVALVTGGANGVGRAVVEKFLTEGARVAVLDRDIDRAKALAADLGADVHVTIGSVENFADNQRAVAEAVETFGKLDIFIGNAGVGAGNLLLSEIPADQLEAAIDEIYAINVKGYLLGARAATPALLRTNGNMVFSCSLASYRAVDDGALYVSTKHADLGIVRGIAWELAPKVRVNGVAIGVARTRMEGLAALGQQPIDAVLPGAENVIPLGFIPEPSDYAAGFAYLASAEARVVTGECLWADSGFGIRGIGSPAGLTMLESKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSG6</accession>
    <name>A0A231GSG6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000764">
        <property type="protein sequence ID" value="OXR39532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39532">
        <property type="protein sequence ID" value="OXR39532"/>
        <property type="gene ID" value="B7C42_08400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="43" mass="4682" checksum="29DD3DD997EB7F5B" modified="2017-10-25" version="1">MTSSRAPMARPIAPAKDGSMYILVPSLLRVMEVEMMMSRSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSP7</accession>
    <name>A0A231GSP7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000103">
        <property type="protein sequence ID" value="OXR39649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39649">
        <property type="protein sequence ID" value="OXR39649"/>
        <property type="gene ID" value="B7C42_08280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="56" mass="6264" checksum="6753E02E2D45AC49" modified="2017-10-25" version="1">MEKLLDAAQRDYDMPPGARWVPARLGGTAPTLEQAKVLEREEMERRAAAKARRAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT03</accession>
    <name>A0A231GT03_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase NlhH</fullName>
            <ecNumber evidence="2">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nlhH_9</name>
        <name evidence="2" type="ORF">B7C42_08179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000073">
        <property type="protein sequence ID" value="OXR39750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39750">
        <property type="protein sequence ID" value="OXR39750"/>
        <property type="gene ID" value="B7C42_08179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="32792" checksum="8B8089A040B335DF" modified="2017-10-25" version="1">MTTPDHRRSPYEVSLDESTPPLRVRVYPATTRGAELTDGLLWMHGGAFVGGDLNMPEGDAVCRALAANGICCLAVDYRLAPKFGAWRAQRRPDAVRYPAPVDDCERAWRYLDDNCARLRIDPRRRYIGGASAGATLAATLTLRLLRTSEPARAAGAVLAYPLLHSELPAAAAPLRADLSRSRRLGQFSPAAVRWIARNYVGRGRTDRLSHAFPGGSDLSGFPRTLIHNSQYDSLRASGERFAEELRAHNRPVDIGFEPGTRHGHLNRPDRPAFAATIRTITDWIAAGSQSISQPVKSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTQ4</accession>
    <name>A0A231GTQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-dependent extradiol dioxygenase</fullName>
            <ecNumber evidence="3">1.13.11.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hsaC_4</name>
        <name evidence="3" type="ORF">B7C42_07920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.25" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000046">
        <property type="protein sequence ID" value="OXR40000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40000">
        <property type="protein sequence ID" value="OXR40000"/>
        <property type="gene ID" value="B7C42_07920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047071">
        <property type="term" value="F:3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="143"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="34902" checksum="8008D380F449C567" modified="2017-10-25" version="1">MTEIKGLGYVRVLATDIERWRELGFDVLGFAPGFGVEADALHFRMDERPARITVERAEVDRVSAVGWEVRDGAALRRLAATVEAAGFECTPMSQELADRRKVEAGFCMKDPGGTPLEFFHGPVLEHSPVLTKYGQRFVTGEQGLGHVVMPTTNFDESFAFYTETLGFLARGAFRMPSPPDAPPQRIRFLGVNQRHHSLAIMPSLEGRDPGLIHVMVEVDELDAVGRAYDQVMARDFPVSSTLGRHTNDKMISFYVRVPGGWDIEYGTGGKLVDETYYTAEEITADSYWGHEWMWARQLKEAQQAEAQQASAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU01</accession>
    <name>A0A231GU01_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40035">
        <property type="protein sequence ID" value="OXR40035"/>
        <property type="gene ID" value="B7C42_07880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="31147" checksum="996A513E58F711B4" modified="2017-10-25" version="1">MSDNIFPPSETPNVSANDSAASSGNSGAPAPRTAFRSRALASPLAVRFGPDDPDAVHAIALRAVQDSMKRYIDWQHHEPPDATAAGPGEWRVTAINGIEDDLRRAYLDAVHAGVPIHEIDSAHELGRAGVGWDQQPAHRLLGRLERLAQELTLAEAHRGTDRSRIRDLESELDRAHTRNADLTEDLAHARNITLSQTEEIVDADWLTGNRHHNTAPGPQPARALAQTNAELALANDIDALDHTTSSDISRGIGAAIDTALPGRPDYWPDTTDPDIGPAPGTSDHGPEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU44</accession>
    <name>A0A231GU44_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">desII</name>
        <name evidence="6" type="ORF">B7C42_07774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.30" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000039">
        <property type="protein sequence ID" value="OXR40150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40150">
        <property type="protein sequence ID" value="OXR40150"/>
        <property type="gene ID" value="B7C42_07774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="116"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="459" mass="50560" checksum="5CA6AF3FC8396A5D" modified="2017-10-25" version="1">MKNTLMDKAYRFLRSDDELARLTTEVLDHASADTAFRATLVCHLAAPHTPATTLAEHVGVDIAAVRDTYRFARTHPGLQQLVRSLYYPHRLRSAFAAATVAEWLRRPEVPQRILAREPVLAETVEIHPTRGTCNYRCRMCLWSDQAELTYATKQLDTGGLMTVDDWLRVLDELASAGVRRLIVSGGGEALINPDLPDILGRAADLGFEIHVYTTGFAARPGSRLFAALLRCHRIRFSVHSCDPVTYDHIAGTRPRQHALDRVTANLGALLDEHQGTPALGIGMVIQQANHAQIEAMTDFAEALGVDWLDIRKDEVDVTDGLDPTQLPVVRQQLRAVRTRAGGATRIDIGDELVALANGLTPDRSRTTECLGRWFRPTIGAFGHLTPCDLKAEPRFAATGYDLGNVKRTRILDVVATSNKQRISDDCTQCMPSSRTGNAIVHKLLADIQAGVGLDEQPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC3</accession>
    <name>A0A231GVC3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FO synthase</fullName>
            <ecNumber evidence="9">2.5.1.147</ecNumber>
            <ecNumber evidence="8">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">fbiC</name>
        <name evidence="18" type="ORF">B7C42_07389</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="9"/>
    <dbReference type="EC" id="4.3.1.32" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40580">
        <property type="protein sequence ID" value="OXR40580"/>
        <property type="gene ID" value="B7C42_07389"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00293">
        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="56"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="521"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXR40580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="843" mass="91927" checksum="C86BD2475E278DA0" modified="2017-10-25" version="1">MRRALRRARDGATLNLDEAVVLLHARGADLEDLSASAVRVRDAGLRETYSGDTLPITYSRKVFIPLTRLCRDKCHYCTFVTVPGKLRAEGHGMYLEPDEVLEIARKGAELGCKEALFTLGDRPEDRWPEARQWLDERGYDSTLDYVRAMSIRVLEETGLLPHLNPGVMSWAEMSRLKPVAPSMGMMLETTSERLFTERGQAHYGSPDKDPQVRLRALTDAGRLSIPFTTGILVGIGETYAERVDSILAIRKSHKAFGHVQEVIVQNFLAKSDTAMRDTPDADLAEFRATIAVTRLLLGPKMRIQAPPNLVSLDECRALIDAGIDDWGGVSPLTPDHVNPERPWPNLDVLAEVTAQAGYTLTERLTAHPKYVLAGNPWIDPRVLGHVAALADPRTGLARDVNPSGRPWQEPDQSWESLGRVDLNTAIDTEGRNTESRSDSGLDSDGLGAFGDWETVREQVLSLSAPVKLDTDVLGALRAAEQDPAGLSDEQYLALATADGPELDAIAALADQLRRDTVGDDVTYVVNRNINFTNICYTGCRFCAFAQRKGDADAFTLSADEVAERAWEAYVEGATEVCMQGGIDPDLPVTGYADLVRAVKKRVPSMHVHAFSPMEIVNGASRGGQSVHDWLSALKEAGLDTIPGTAAEILDDEVRWVLTKGKLPTSAWIDVITTAHKLGIRSSSTMMYGHVDNPKHWVGHLRVLRGIQDETGGFTEFVLLPFVHQSAPLYLAGASRPGPTIRDNRAAHALARIMLYGRIANIQTSWVKLGITGTQVMLNGGANDLGGTLMEETISRMAGSEHGSAKSVAELVEIGAGIGRPVRERTTTYGIPKHQVSALPLTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVJ4</accession>
    <name>A0A231GVJ4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40592">
        <property type="protein sequence ID" value="OXR40592"/>
        <property type="gene ID" value="B7C42_07277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="235"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="569" mass="63931" checksum="F82D6D87D7CA7FEC" modified="2017-10-25" version="1">MKTTKRDNKSGTVRYLHLAHSEWDPIKGRATPRVLFTFGREDELDRDAIKRLVASLSRLLDPADALAAGAAGEGLAFVSSRPFGGAYALDHLWRWLGIDAIIAGLGQPKRGRRRDVSAIERVLFALVANRALSPSSKLAAAEWISADVHIDALGEVTDDAYYRAMDWLHDVKDDLEHQVFDRIATLLNLEVDLLFFDTTSTYFETEDADDPIVRDGKGNPVTGPGTDEAGSDAVGFRTWGKSKDSRDDLPQIVIGMAVTRDGIPVRCWCWPGNASDQTLIRQVKDDMRDWTLSKIIWVTDRGFSSAENRRYLRRGDHHYIIGEKLRSGSVEVKAAMSRQGRYLDVAENMRVKEVRVSEQERFVICFNPDAAERDAATREQLVAALREMIDGSDALSDFKRGELRGKIAGKPGLNRFLRVTAGGKLRVDAAKIKAEANFDGKYLLRSSDPNLSSEDIAIGYKQLLEVERGWRDMKSVLDLRPVYHRLEERIRAHMLLCWLALLLARIAETRTGTTWPTIRRELDRLHIGTFTGPAGTFRRLTELTKPQRDLLTRLGAATPKQIIELTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVP1</accession>
    <name>A0A231GVP1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40625">
        <property type="protein sequence ID" value="OXR40625"/>
        <property type="gene ID" value="B7C42_07310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="27672" checksum="0E307BB0C6237CD3" modified="2017-10-25" version="1">MGAMTGARQRVLEVGSSVVRRVDARSSRWAEHRVTVRAELVDAAYRAFGKYGPDASMDDIAREAGATKPKLYRHFKDKQGLRAAVVERAKDLMWSNILASSDFATAPIGEVMSQIVGQYSELVDEHQNVFQFLVRSHFDDNSSETDQALEDARELAGFIAGHFSAVLESLGADTTGIDLVVQSIIGASLSATDWWINSQADPETAMSRVDFADNLSAIVWGIIDASAQVRGIRIDPRQTLRIENIETVDVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWB5</accession>
    <name>A0A231GWB5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40865">
        <property type="protein sequence ID" value="OXR40865"/>
        <property type="gene ID" value="B7C42_07000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15401" checksum="9513B6063C68B091" modified="2017-10-25" version="1">MEQRAPDAPTELPSRAWRAVLRNSLREFKNDELADRAAALTYYGVLALFPALLVLVSLLGIAGGSATARVMDNLRRLAPGSTRDLLVQAVEQLQGRSGLGSVRCRRAGSRLRRGLAWNEVPESCAAVVGSGADAIRPSVPILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD5</accession>
    <name>A0A231GWD5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine-binding lipoprotein MetQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">metQ</name>
        <name evidence="6" type="ORF">B7C42_07023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40888">
        <property type="protein sequence ID" value="OXR40888"/>
        <property type="gene ID" value="B7C42_07023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375767" evidence="5">
        <location>
            <begin position="36"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="34094" checksum="4317BCD51B5CCDC4" modified="2017-10-25" version="1">MHRTDRRRPPAAMRAPVRRRIATVVASLLLVPAAAAGCGSATKVSYEPAADDENALVVYVDRGDDREILDYAIHNLLPDSVKVKPVDATGDANARIAAGTGDLSYFQHIPAFEADSQKNSYTNLSIVSKVNVVPYAVYSSKWRDLKNTTDWVHVGLVQDQVAGVSLPHGAQVALPATPTGFARGLYLLQSAGLVTLDRPFGGTSAADLTIGQANVRDSARHLSLLPLSFDQDLRSIYQSYDAVVLSPEQAASLGLQPAKDALAIEPGPENPYAHVLVAPSRLAGDQRVLELTHALESPRLAQFLATKYGGADIAVAAAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF6</accession>
    <name>A0A231GWF6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvoyl-dependent arginine decarboxylase AaxB</fullName>
            <ecNumber evidence="4">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pdaD</name>
        <name evidence="9" type="ORF">B7C42_07105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvoyl-dependent arginine decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40821">
        <property type="protein sequence ID" value="OXR40821"/>
        <property type="gene ID" value="B7C42_07105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="182" mass="19176" checksum="3DFFD6F5129EC845" modified="2017-10-25" version="1">MLTTHTSLDPLGRRDRDREGSATLTIEIGTATGTGATEVAAFDAALCELGVGEANLIRLSSVIPPRAQLRRTARVRQRIGWGDRLYCVYALGHARTRGATAAAGIGWTLCADGSGAGLFVEHAAETTEQVEDLINASLADMTAARPGRFGPIHTATVAARADGRDTCALVLAAYRTSGWDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWI4</accession>
    <name>A0A231GWI4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40956">
        <property type="protein sequence ID" value="OXR40956"/>
        <property type="gene ID" value="B7C42_06922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="666" mass="72107" checksum="F7BA6BDA80559E16" modified="2017-10-25" version="1">MLCRVSKLTTAVKRMVVGRPFRSDSLGHTLLPKRIALPVFASDALSSVAYAPEEIFLVLSTAGLSAYVYTPWIGLAVAAVMAVVVASYRQNVHAYPSGGGDYEVATVNLGPMAGLTVGSALLVDYVLTVAVSISSAASNIGSAVPFVATHKVLFAVAAIVLLTAVNLRGVRESGTAFSIPTYGFMIGVFLMLAWGVVRIFVFGDELHAESSGFSLNGNESHLQGIAFAFLIARAFSSGCAALTGVEAISNGVPAFRKPKSRNAATTLLMLGAIAVTLLMGIILMARKLGVVFAADKADLVGAPPGYEQKTLIAQLADSIFSGFPAGFFYITIVTALILVLAANTAFNGFPVLGSILAQDRFLPRQLHTRGDRLAFSNGILFLSGAAIAFVVLFGAEVTRLIQLYIVGVFVSFVLSQTGMLRHWTRLLRTETDPAVRRRMLRSRVINAIGLTMTGAVLIIVLLTKFLAGAWIAIVTMAAIFGLMRLIRRHYDTVGRELEEQEFTGVLPSRTHSIVLVSKLHLPTRRALAYARATRPDTLEAVTVNVDEPDTRALVREWADSDIPVPLKVIESPYREITKPVVDYVKRVRKDSPRDVVTVFIPEYVVGHWWEQLLHNQSALRLKGRLLFEPGVMVTSVPWQLSSSAKARRPEVVNAPGAVRRGYEDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWL7</accession>
    <name>A0A231GWL7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrogen peroxide-inducible genes activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oxyR_3</name>
        <name evidence="3" type="ORF">B7C42_06969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41003">
        <property type="protein sequence ID" value="OXR41003"/>
        <property type="gene ID" value="B7C42_06969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="33006" checksum="9753A397CB4BD43D" modified="2017-10-25" version="1">MISCTILIGVTDQTYQPTLSQLRAFVAIAEYRHFGTAAAHLNVSQPTLSQALASLENGLGLQLIERSTRRVLVTAAGKRLLPQAMATLEAADRFVATAAGDGLGGTLRMGIIPTVAPYVLPTLLPELRRRLPALVPHVIEDQTARLLDGLRSGVLDVAMMALPSEATGMVEIPLYTEEFVLVTPLGHALAGRSDIAPAALDELPLLLLDEGHCLRDQTLDLCRSQDVRPGPVGDTRAASLTTVVQCVGGGLGVTLIPEMAVAAETSRGTLDIARFAAPAPGRTLGLVFRGSTARVEDYEQLAEIIRAQRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWT6</accession>
    <name>A0A231GWT6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium, potassium, lithium and rubidium/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaK_2</name>
        <name evidence="8" type="ORF">B7C42_06937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779401.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40971">
        <property type="protein sequence ID" value="OXR40971"/>
        <property type="gene ID" value="B7C42_06937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="6"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="529" mass="56926" checksum="947A6105A40FF04B" modified="2017-10-25" version="1">MDQLVLVFVLAFATILAQPLGRRIGLAPAVLMTVFGLVMAVLPFVPNIALAPDLILPLVLPPLLYASARRTSWQQFASNAGAILLRAVGLVVATAAAVAAIFHLWYPALPVGTAFALGAVVAPPDPVAVSAMADRLGLPRRLVAVLEGEGLFNDVTAVVIYDVAVHAVVTGQFSAWRTAIDFVVSAVVAVAVGLALGWAGSAMMRRLTEAPWQVALGLLLPFAAYGLAEAAHGSAVLAVLVCALYLTDAATDFSDVGYRIVGDSFWDVIDMLVTGFAFGLVGLELSTVLATTGPNWPRLLGGAAAVVGVVVALRLVWLLASTGLFRGWWRRRRMDEPYTWRETVVTWWAGMRGVVTVALALALPLTTDSGAAFPGRTEVLFIAFVVVLFTLLLQGPTLPLVARWTGVKADTEVERAMERRLWTRILRAELARLEEIADNEDLPDEVYQRLRDTVERRLMRADPEAAEAADGSKAVEQAMRLTGKLRTISNDVLDAGRGEALAARREPGMPPDLVDRVMRRLDLRPPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWW0</accession>
    <name>A0A231GWW0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Curved DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cbpA</name>
        <name evidence="2" type="ORF">B7C42_06873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41103">
        <property type="protein sequence ID" value="OXR41103"/>
        <property type="gene ID" value="B7C42_06873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="33045" checksum="54AC1E64A05C0068" modified="2017-10-25" version="1">MARDYYEVLGVPRGAGTDEIQQAYRKLARKYHPDVNKDPTAEDKFKEANEAYSVLSDPDTRKRYDRFGDDFRRVPEDYDERVRASAGGYGGTGRRVRFGQGFGGEGAVGFEHLFGQMFGGAGGYGPIPGADQEAELELTLEEAYRGGKRSLRLDGRQYDVDIPAGVLDGQRIRLAGQGGRSNGDAPPGDLYLVVRIKPHPRFRVQGRDIYVDLPVSPWEAVLGSTVVVPTPGGEAKVKVAPGSSTGRKLRLRGEGMPNPRGAKGNLYAEIKVMVPSKPTARERELFEQLAAESNFDPRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWX8</accession>
    <name>A0A231GWX8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trxA_4</name>
        <name evidence="5" type="ORF">B7C42_06876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41106">
        <property type="protein sequence ID" value="OXR41106"/>
        <property type="gene ID" value="B7C42_06876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16127" checksum="806EE95C9B77A00D" modified="2017-10-25" version="1">MRTEKVKCPNCGKVNKVAAAGEGKPRCGNCHEPLPWIASAGDDDFAEVAERSSVPALVDLWATWCGPCRMVSPALEQLARERAGRIKLVKVDVDAAPRTAERFTVRAVPTLLVMDRGEVLARQAGAAPVPQLRTWLDQALSAHAAKEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWY2</accession>
    <name>A0A231GWY2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpA_11</name>
        <name evidence="2" type="ORF">B7C42_06987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779459.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41021">
        <property type="protein sequence ID" value="OXR41021"/>
        <property type="gene ID" value="B7C42_06987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011264473" evidence="1">
        <location>
            <begin position="32"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="35234" checksum="E027E19FE770319C" modified="2017-10-25" version="1">MSRRFGGRYRRRAVLCLAPAVVAALSSGVGAATTEASAFADGSRIDRIIETDARHATLVVYSAAMDRTVSMRVLRPAETSSPVLYLLDGAEDGIGPGGTETSWETRTDVDAFTADKDVTVVTILDGRYSYYTDWLADDPVLGRNEWTTFLTRELPPLVDAALHTSGRNAIAGVSMSATSVLALAQAAPGLYAAVGSFSGCAQTGTDPGRRFVQAVVASGGGNPWNMWGPDGSPGWADADPSTPANVEKLRGTELFVSAGVPRPGSATDGPAVADPAGGGALESVVAQCTRRLQEVTESRGIPATYRYTPGGLHDWPYWERSLHEAWPGFARALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWY3</accession>
    <name>A0A231GWY3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase 2</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lip2_2</name>
        <name evidence="2" type="ORF">B7C42_06858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41088">
        <property type="protein sequence ID" value="OXR41088"/>
        <property type="gene ID" value="B7C42_06858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="88"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="34066" checksum="8B803679CDAC68CA" modified="2017-10-25" version="1">MGLSETAMLDLLDEDACAFAQALLSQAPPPPYARYGVEGVRSIFDTVDGARQPIRPVHSVEERAVDGPGGPLRVRCYRPSSARGLPAVIYIHGGGFVVGTLNGVDDVCRSLCAEAECVVISVEYRRAPEHVFPAAADDCLWTYDWVEREAVSLGVDSSRIALGGDSAGGNLALSVCTALAEARRAAPRALVLAYPATSNTHAGPSWDAFEHAPVLCKTDALWFWSNYAADSEADPRAVPILSDTLHALPPTLLVAAEVDVLRSDYEHFAATAARAGAEVEIRQYDGVPHGFFTEVAVIEKARHAVADAAHHFRTHFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXL5</accession>
    <name>A0A231GXL5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE12</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_06703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41305">
        <property type="protein sequence ID" value="OXR41305"/>
        <property type="gene ID" value="B7C42_06703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="388" mass="43143" checksum="9F94E431DD1F9731" modified="2017-10-25" version="1">MDFQLTEDQVTIRDAVAELAAKFDDQYWQEKDEKHEFPTEFYNAFAQGGWLGITTPEEYGGHGYGITEASILLEQVAASGAGMNGASSMHLSIFGMHPVIVHGSEELKQRTLPRIVSGDLHVCFGVTEPGAGLDTTKITTFARREGDSYIVNGRKVWISKAVESEKILLLTRTQKFEDSPRKTDGMTLFLTDLDRDRVDIRPIKKMGRNAVTSNELFIDNLEIPVEDRVGEEGKGFTYILDGLNPERMLVAAEALGIGRAALRAGVRYGNDREVFGRQIGRNQGIQFPLADSLARLDAAELMLRKATWLYDNGKQCGREANTAKYLCADAGFEAADRALQTHGGMGYSEEYNVARYFREARLTRIAPISQEMVLNFLGSHVLGLPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXN0</accession>
    <name>A0A231GXN0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fumarate reductase flavoprotein subunit</fullName>
            <ecNumber evidence="9">1.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">frdA</name>
        <name evidence="9" type="ORF">B7C42_06502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41359">
        <property type="protein sequence ID" value="OXR41359"/>
        <property type="gene ID" value="B7C42_06502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="7">
        <location>
            <begin position="31"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="8">
        <location>
            <begin position="479"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="539" mass="56185" checksum="8C9673A6F4F9066C" modified="2017-10-25" version="1">MNCGRIFSFVSVRSWSTIRAESEIAAEASADVLVVGGGPAGAWAALTAATAGARVTLVDKGRCGECGPTSKGVVALWDIPPGPDRERALARSLSHGGDLGDPEWMDRVLGETHHRIAHLLRWGYRQAGDGLATRVHLEGRRYLAALRRTLFRLGVQVVDHHPALYLLVDGDGVVCGAGGLAGDDHYRGWTIRAGAVVLATGGCAFLAGGAGTDVDTGEGLLMAVEAGTELSGMEFSGAYGLATMSDLREPRFANLYDESGARIDGDDFTARSAALAALAQGHPVYADIPPGPAVRYGPASAAPAGSTAVSATAGAAASSVDPRSGRVRLRPVLQGTVRGSGGVRLTGFDCATTVPGLYAAGDVASREPITGAVGGFDGHGGGWAISSGMWAGSGAARFARRRGRIGDARPVPGAGLNHHLGADARADIDPRAVIGLVQEHTLPLRRSYWRSAGSLRDSIAELDAMWPVTEYGLGGTGADQVRARQAAALLAVARWTKYSALARTETRGLHRRTDHPGPARDWRRRLLTGGVNEIWVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXY1</accession>
    <name>A0A231GXY1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytochrome P450 140</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780371.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41432">
        <property type="protein sequence ID" value="OXR41432"/>
        <property type="gene ID" value="B7C42_06575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="47554" checksum="E3BD05B3F0F70C37" modified="2017-10-25" version="1">MKPQYWFRWLVVQGTPRLALKTYARRGETLAKLMSSPEAVQDPIPLLESLRAQGRLVHSPLGWATTDYELVRTVLRDNTFKVAAAEGFVPGPLRPLMDLATLPPNPVQPPSMLVIDPPDHTRMRKPVASAFTPRAIARLRDRVESVTTELLDALPSGGSADLVADFASQVPIAIISEMLGFPDADRDHFLAWGDAVSPMLDIGISWRTTRDASAAIVEMDHYLDEHIARLRREPGEDILSGLVSSGTLDDTELKASATLLMGAGFETTVNLISNGIVQLVTHRDQLDRLREDPQLWPNAIEEILRFDAPVQNTGRIAGREVELAGITVHEGSTVVLSLSGANRDPKVFAEPHRFDVTRANAKDHLTFSSGIHACLGASLARMEGTYALRSLFERFPNLVLAGRPQRRPLFTLHGYSRLPVLLGQRAEQPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY95</accession>
    <name>A0A231GY95_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043222.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41566">
        <property type="protein sequence ID" value="OXR41566"/>
        <property type="gene ID" value="B7C42_06459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="36520" checksum="EA180AF1A4A5AFF8" modified="2017-10-25" version="1">MRRHRARALLRAAFASGDSRRREVRLGLLGLALVVVLPAAAVVTYELPLGKHTYHADLPEAGALTVGDSVRVAGIPVGTVRGLELLADRVRLNFTVDENVFVGDATTLDVRMLTAIGGHYLAVLPAGRKPLGDTVIPADRVRLPYSLMQVFQDAARPIGDIDGGTLRKNFAALASAVPNSPDAVRRLGQAVDSLVDIMNSQREDISQALKVADEYLTAMDRNKEQAFHLISSLRRVEDTVFAKNHEIIAGLTITDRLLARLTALRPIWDSSLKPLVDEIAGIVPELRRFGADTGASLAAVQRTLERLNELVTPQGTVAVDRSAQVVDGGPICVPMPGAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYH2</accession>
    <name>A0A231GYH2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoserine phosphatase RsbU</fullName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsbU_2</name>
        <name evidence="3" type="ORF">B7C42_06305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41664">
        <property type="protein sequence ID" value="OXR41664"/>
        <property type="gene ID" value="B7C42_06305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="137"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="303"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="535" mass="56472" checksum="E7714741A4523246" modified="2017-10-25" version="1">MPESVVSGVDRWSAIPHPAVVVDRAGTVVALTGDAAALVPDAAVGEPLHRAALPWLSAAHDATAASDGVSAPASVSGRVGGRELHAVASPGADGTIVWWLLGETARSLHESRSELEQERDRTAFLSQASEQLLASLNVDRCLETTVRLAARHLADAAVVVTPPAGRALSVVSCDEHGAVRVTVVEEDPDAVAGLSEALRGFPPIPSQWLDAAAVPAWLLPPGFANRTGSVIVTPLPGHGVSAGALVLLRRCGERIFDERDEVFAQLFAGRAGIALSAARLYAEQTSITAILMRELLPPQLHRVHGIELAGAYRASENHEIIGGDFYDVHRAATPDEETLVVLGDVCGKGLEAAVLTGKIRNTVHALVPMADDHQRMLALLNDALVSSRHNRFATLVLASAVHRDGRVLLRLTSAGHPPPLIVRADGTVETAETRGQLVGALPDITATTFRTSLAPGETCLLYTDGVTEARGGPLGRRMFGEERLIAALAQCADMPAEAVVERVHMLTTQWVGRNQHDDIAVVAITAPRTPTVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYZ1</accession>
    <name>A0A231GYZ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41792">
        <property type="protein sequence ID" value="OXR41792"/>
        <property type="gene ID" value="B7C42_06134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="181" mass="19756" checksum="879DC087CFB182AF" modified="2017-10-25" version="1">MTARTRAGTRGADTADDAVAEVMRQWAQAAPELDLSPIAVIGRITRCAALLQQVADAPLGDEDLARPEFDILLALRRVGGELTPGRLARETFASPAAVTKRLRGLEERGLVGRRADTRDRRVSHISLSADGRALIDRLMPRQLAYEAGLLSGLPDDDQRELARILADVLVRWEGRFGGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYZ4</accession>
    <name>A0A231GYZ4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dhbF_7</name>
        <name evidence="11" type="ORF">B7C42_06175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41833">
        <property type="protein sequence ID" value="OXR41833"/>
        <property type="gene ID" value="B7C42_06175"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR41833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1314" mass="141210" checksum="F7FC99EE9818F88E" modified="2017-10-25" version="1">MVDLSSTTRRHDATPDADFFELSVAQYELWLAQQLHPTVPFSISQYTDVHGDLDLELLQRCARRAARELQSPHVRFAIVDGRPRQYLDHDADTGFDCIDLSDHPDPERAAQEWMSQDHHAGIDLTGDDVTRTVLFTLGPGRYRCYARSHHIAVDGFGAAQVLQRTAELHSAATEGRPAAPCRAVSLAEIVAAEQRYRSSSRFAADREYWGRQLAGLDHTTRLSARYAAPSARPHIAHATVDAEVMARLGAAADRYGTGTAEVLVAAVTAFLAQMTGDTDVTVSLPVAGRTTGALRQSAGMVSNVVPLRVRGVAESTVGELVREVRLSMIGALRHQLYRHEDLLRDHGVGQAGRHGYGPLINVLSLPDSIDFGAVRGRTQLLSAGPVEDLAISCYRFGTEPFVIDFHANPELYRADEVEGYRQQFVDCLTRFLRADGTDTVFAAVAGTHTIAAPQRGNHQRLLPDLLAGGIDAGDRIALSGPDRSVTYRELDETTARWARELIAHGAGPEVVVAVALSRSVESVMALWAVARAGAVFFPVNPTDPPARVSKLIADSGAALGVTLTRWRTSLDTTAADWLMLDSDEFTRAAASRSAEAVTDKDRIRPLRAAHPAYLIYTSGSTGEPKGVLSTHEGLATLADDLRTRNNIGRDAVVLQAHSPFCDASMLEYLSAFTPGAQLVAMAPDIVAGQRLSRVMEDEAVTQLIVTPAILATLDPDRLPALRTVTVGGDKCPPALAQRWSGRLPMFNSYGPTEATVVVTQTEPLAPGSPITIGRGLPGVQTLVLDARLRPAPRGARGELYLAGDALARGYLGRPGITAQSFVANPYGQPGTRMYRTGDMVREQPDGALEYLGRGDVQISLRGQRIEPSEVERALAADATVDQAVVRVWTSETLGDRLIGYVVPAGAGEEFDRAAVLARLRTVLPPGMVPAMLVPLPEIPINPSSGKTDRSALPDPQTLPRPAFRAPASEIERTVAETIAEVTGQPRIGLDDNFFELGGNSLLGVELCRQLSERTGTTVTISSLFTPTVQTLAAAIEATAAGGTSEAAVGGSALQPVLPLRGSGSGTPLICLHSAVPLAWCYSGLLRYVTDRPVYGLQSPAVSGQSRRYHSVDALAEVYLRELTRVQPEGPYHLLGWSLGGQLAHALAARLRARGHDVGLLVMLDSVAFGEGAPQPEPPTVRDLVTHLQGNESATPDTRPLTLDEAVDVLADSPGPGRGLTREQLERLHQGYVDSVAMSTSYRPASYDGDLLYFSATEGITGELTGEMWRPWVSGRIAEHRVDVTHAQMTNPEALAVIGPILEAELNRHGEGKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ80</accession>
    <name>A0A231GZ80_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-keto-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ipdC</name>
        <name evidence="13" type="ORF">B7C42_05910</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41926">
        <property type="protein sequence ID" value="OXR41926"/>
        <property type="gene ID" value="B7C42_05910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="TPP_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PTHR43452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="203"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="404"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="540"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR41926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="570" mass="61025" checksum="7C83C625B7AD1B89" modified="2017-10-25" version="1">MSRRETQRMTIGDFLLRRLEEAGISHLFGVPGDYNLELLQQLEDHSSLEWVGNCGELNASYAADGYARLKGMGALLVTNAVGALSAINGVAGSYAEHVPVVCICGSIPLRSIDRGLGMHHTMADGTRDRFLGAFAQVTAAQARLTPSNASIEIDRLILTAWREKLPVYLELPSDIAYLDIEVPAESLVLEQPSSDSERLESCINAIVGHLSAASSPAILVDLDVDRFGVAGEVMELAGKLQIPVAVSSTAKAVIDETFPHYVGVYNGNASAPSTLDAIQGSDCLLCIGYRPIELTTGDFTAALPADAIHLRGHSADVGDSNYQAVAIAEVLRGVIAALPYATGHAQVARQPMDAAARAHLDNEVELTQAEYWQAIQSYIRPGDVLLVDNGTSYALFGLQLPPGCTFVGSVNWGSIGYSVAALLGTLTAAPERRHLLFVGDGSFQLTAQELSTILRHDHKPVIFLINNGGYTIERGYLGKTESYNDIVTWAYAALPKVLRPDTTARSFVAETPAALHNALAAPNDRLIFVESIMDRFDSPAAVTSSSNRGAELDYGPRGPHHQEGAQLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZE7</accession>
    <name>A0A231GZE7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosom_S30AE_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41945">
        <property type="protein sequence ID" value="OXR41945"/>
        <property type="gene ID" value="B7C42_05929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="1">
        <location>
            <begin position="121"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="27725" checksum="F2D777E130E932B9" modified="2017-10-25" version="1">MLRESQAWSSAAFPDIVIFTRGPVPALEAERVAGAVGRLLARHTVTGGARVRVTAAAGESETLLVQVNLARSDRPVRMQVRTRGPNEVLSVVVRLERQLTGATVRDWPDPARPALANPGAGKIVRRKVFALDTLRPKSAAAVMDALDFDVHLFVDAETGEDSVVYRAGPSGLRLARRSRMHPPSDTGGRIFTVHSRPTPVLPESAAVERLCEHGLPFVFYLDAFTGRGHLLYRRYDADLTLVTPGAEAEFDTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZI4</accession>
    <name>A0A231GZI4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerol operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gylR</name>
        <name evidence="5" type="ORF">B7C42_06018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42034">
        <property type="protein sequence ID" value="OXR42034"/>
        <property type="gene ID" value="B7C42_06018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="295" mass="31035" checksum="1CBA34DDB4590FBC" modified="2017-10-25" version="1">MPTGNTGRAESSPPTRRVVSVVELLAAHDGALTSAEIADTLGLSRSTMGAILGTLEETGWVRRLPDLGYEPGPALLVLGGRLRDRLRDHDRVEAELRRLAERVGCGAALTSIAGSEVIFVAVAGGPGLIPAGIEAGTRIPLRPPAGAAVLAHAGLPAQRAWLQQAPPERRAEFEQVLETVRALGYCAWGLDAASLPTLRVLAEVVDHLSDRPADKALRERVLALLATIGGTAHSRADLDSDRALPISYLTVPVFDGERVAMEVQIGPLSAAVGAVERAEYVRETVSAARRIAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H089</accession>
    <name>A0A231H089_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42285">
        <property type="protein sequence ID" value="OXR42285"/>
        <property type="gene ID" value="B7C42_05484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="36348" checksum="2C44E39ACC432702" modified="2017-10-25" version="1">MATVLKTLLAERHLKSHSDFLAAYDACAARLDPPVPPGYGPAKTQYYQWLSGKMVGLPRDYHCRVLTEMFPGWSIESLFRTAAEPTPVTVGADEPGRAADDIELAAFLGAETLAGGVTLVYPAFELPLRSARARRALAASDRYSFPRKIRAIAAGHRSDALTALPEKEFRALLYVLSMLQRHTGLSTDVRSDREVAAHSERPYISFGLTGNTCTRRYLDNVERPLFDLDGRGRRIEQVALADGSRYGSRDGHSIGVIARVRPDPDLYPGRYRIFCAGLGPRGTTGAGWYLATSWAPLQRRAGDQEFVAVVDIGDSSDETARLEYLLIESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B5</accession>
    <name>A0A231H0B5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42262">
        <property type="protein sequence ID" value="OXR42262"/>
        <property type="gene ID" value="B7C42_05461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="14624" checksum="1C77968C27C15353" modified="2017-10-25" version="1">MVLTLDEAHAISARIRSRAAKLGARVTVAVVDEGGHVRVLDRMDGAPPLSARIAPAKAAGVALFHRDGGELQQLQKAWPALFDRIDRLSPAPIVVGAGSRLIRRDGVVLGAVAVSGGRPEQDDECAEFGLATSRSTPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0C5</accession>
    <name>A0A231H0C5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780599.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42323">
        <property type="protein sequence ID" value="OXR42323"/>
        <property type="gene ID" value="B7C42_05522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007804">
        <property type="entry name" value="Gas-vesicle_GvpG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05120">
        <property type="entry name" value="GvpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8317" checksum="2C9BE3BB1908EAF4" modified="2017-10-25" version="1">MGVISSILLLPAAPVRGVIWLSELIQEQVEQQMHDPVRLRRELEDIDRAAAAGEISAEEAAQAQQEILNRMTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0N3</accession>
    <name>A0A231H0N3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42378">
        <property type="protein sequence ID" value="OXR42378"/>
        <property type="gene ID" value="B7C42_05577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="114" mass="12411" checksum="B513A12F749F0696" modified="2017-10-25" version="1">MPGGQRFSLVLGFLGRSADDQKARRREDESRLTPEQLRGEFKLALRIARTTGVVYPDNGLDKVVEDAIGEVAMGCPDPAPELIAAAEHAFAGMLDGSNAARARQDLLDWFDSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H160</accession>
    <name>A0A231H160_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42595">
        <property type="protein sequence ID" value="OXR42595"/>
        <property type="gene ID" value="B7C42_05372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="15412" checksum="31FAEA1415F841BF" modified="2017-10-25" version="1">MFAMAIATGSIAHVRLTVCDIGRSRDFYDKVFGWPVALEVPADADQETRERLGFLYGGVIYRLEHGLLGLRPVGTDRFDENRVGLDHIAFPVSSLAELEAAAAHLDACGVAHEDIKDIGVSYILEFRDPDNIALELVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H205</accession>
    <name>A0A231H205_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780174.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42862">
        <property type="protein sequence ID" value="OXR42862"/>
        <property type="gene ID" value="B7C42_05200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="132"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="26712" checksum="5FDCF9DE0121C664" modified="2017-10-25" version="1">MTTRLACVVFDAIRPRNVARFWAELLDWQITVDRPHAVEVAASDPDAADVSLMFVPTAGPKSGKNRIHLDVVGRSLDHQRVQVDRALALGARPIDIGQGAVPWTVLADPEGNEFCVLEPREEYVDTGAVAAIVVDTPHPTRLARFWETAAGWPLTHDESRMSGIRSATGQGPWLEFLRTQVAARECDRVHLDVVSYSTGDPADEVARLTAAGAVPCEGAAVYPPAQAMLTDPETNRFRLLRAPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H287</accession>
    <name>A0A231H287_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphorylated carbohydrates phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42952">
        <property type="protein sequence ID" value="OXR42952"/>
        <property type="gene ID" value="B7C42_04838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23353" checksum="45438D703009949B" modified="2017-10-25" version="1">MTVAAVLWDMDGTLLDSEKLWDIGVRELAEELGGRMTDAIRHALIGADARNALRILFDGLGLELDPAAMLAAGQWLERRVTELMAGPIPWRPGAQDALATLRAAGLPAALVTNTKRSITELCLETLGRHMFDVSVCGDEVDNGKPAPDPYLRAARLLGVAPEDCVAVEDSPTGSAAGLAAGCRVLVVPCEIAVPSRPGLEFRESLVGLTVDELALVHAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2B5</accession>
    <name>A0A231H2B5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malonyl-[acyl-carrier protein] O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.197</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bioC_1</name>
        <name evidence="2" type="ORF">B7C42_04870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.197" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42984">
        <property type="protein sequence ID" value="OXR42984"/>
        <property type="gene ID" value="B7C42_04870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102130">
        <property type="term" value="F:malonyl-CoA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="58"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="27871" checksum="31212DC821BF02CB" modified="2017-10-25" version="1">MTPVPEGHARPADQVGVSGYDSIAEGYAAENETGLLHAYYNRPAILELAGDVSGRRILDVGCGPGPLFAALRERGAVVTGIDASTRMLEQARQHLGADADLRVADLADPLPFPDGGFDDVVASLVLHYLRDWGPALAELRRVLVPGGRLIVSVEHPFANFLGQRLAGDSTDYFEIRNRIDEWTMGEQTARLSFWDRPLHAMTDAFTAAGFRIGVISEPPALPTARDLIPEVLGDSTHNRFLCFLFFVLYADNRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2N4</accession>
    <name>A0A231H2N4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43087">
        <property type="protein sequence ID" value="OXR43087"/>
        <property type="gene ID" value="B7C42_04973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="28835" checksum="5AF6037D13F04F0A" modified="2017-10-25" version="1">MTGAAQWTRGGMSIGSVLDLLRPDFPDITISKIRFLESEGLIRPERTPSGYRRFSVADVERLKFVLTAQRDQYLPLKVIKEQLEAIDRGAATLGVREARARADGAGADGSGRAPEPTRTVGAPAAPRRLGVVPGEVSPDELRLDHEMRVTRADLLEQAGIDEKFLTELIRAGLITPGAAGFFDAEAVTLARTAQAMSEFGLEARHLRAFKLAADREAAMIAQIAAPIAKSRDADARARAEETVRELAALSLTLHTSLVKTSVRASLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Y0</accession>
    <name>A0A231H2Y0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional protein PaaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">paaZ_2</name>
        <name evidence="2" type="ORF">B7C42_04580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43158">
        <property type="protein sequence ID" value="OXR43158"/>
        <property type="gene ID" value="B7C42_04580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17266" checksum="51311985938C4DF4" modified="2017-10-25" version="1">MSSGEKLDPWAIAPVLHGRTFEQMRPGDRFRTGSRTITESDLIAFVTLAGLSEPLFLDERGSVEAGYSGRVVPAALTFAYAEGLVLQTGVLHGTGMAFMRSDLDIKGPVFVGDTISVVVEVLESRPTSSGGRGVVTTENSVVNRDGVVVLEYRPVRLVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H328</accession>
    <name>A0A231H328_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">(2S)-methylsuccinyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mcd_5</name>
        <name evidence="9" type="ORF">B7C42_04676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.12" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43254">
        <property type="protein sequence ID" value="OXR43254"/>
        <property type="gene ID" value="B7C42_04676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="41861" checksum="EF00247CF3E406CD" modified="2017-10-25" version="1">MNHGWLNSEEVLLVETVRAFIDREVKPKVQEFEHANRYPEEWIEQMKRIGIYGLAVPEEYGGTPVSMPCYVQVTEELARGWMSLAGAMGGHTVVAKLLTLFGTDAQRQAYLPRMATGELRATMALTEPGGGSDLQAMTTQARRDGDELVITGAKTWISNARRSGLIALLCKTDPAAVPRHAGISIVLVEHGPGLTVSRDLPKLGYKGVESCELSFDNYRAPVSAILGGAPGQGFAQMMKGLETGRIQVASRALGVAAAALEDALAYSQDRESFGKPIWKHQSIGNYLADMATKLTAARQLTRYAAEQFDRGERCDMEAGMAKLFASEVAMDIALNAVRIHGGYGYSTEYDAERYFRDAPLMIVGEGTNEIQRNVIAGQLVARGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3B0</accession>
    <name>A0A231H3B0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43350">
        <property type="protein sequence ID" value="OXR43350"/>
        <property type="gene ID" value="B7C42_04773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="27563" checksum="BDFDDE3FD26FB1D1" modified="2017-10-25" version="1">MTVPARFGNLGAFVEKRRKQLDLGRAELGRRVGLAAGTIKAIERDERRLVDDNLRKVLVALDVQENNVRLLVSAKEGRLRSDDSAPGGLELRAIEAITVPVFILNTVMGRIVAANQACESLMHLRAGVSIYEWLVADPWTRQLLGQGWRTIAHGLIWGAAPLIECVMPECERERLLEVCSRVPEWETLWTTRPATADYIYGARMTNPGTGETVDYSFTASELRFPPRVGWWQGQLTPADQELARVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3G4</accession>
    <name>A0A231H3G4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43433">
        <property type="protein sequence ID" value="OXR43433"/>
        <property type="gene ID" value="B7C42_04300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="229" mass="25810" checksum="F61574206EADD637" modified="2017-10-25" version="1">MANRRSERMRGRAAAAWRYVRTAPWTFSWLALLLVTTIVQHAVPLDDLKIILGERSTNLSNLKSDPLHVLVTSLLWVAGYFWLPYLVLYCVFHAPAERWLGALRWAIVGLLAHVGATYISEGLLGWAIRHGYADPALVDVRDIGVSYFLAGIIGVLTYHLAYPWRWVYVVAATACFAAPPLIHLTFTGIGHFSAFLIGLACYPLTRTRTAPTWNPAQAWRDRRRRARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H466</accession>
    <name>A0A231H466_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional activator RhaS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rhaS_2</name>
        <name evidence="2" type="ORF">B7C42_04519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43651">
        <property type="protein sequence ID" value="OXR43651"/>
        <property type="gene ID" value="B7C42_04519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="228"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="36698" checksum="8F4A3729202FDAB5" modified="2017-10-25" version="1">MTEPKGYDARHQTSRWSSAHVRTTDADQAVHEISAVFSNHELAVLGPSEQLEVRLHARTTGLLTLADISHGTEVIVHPGELRSYYEINIPIAGGTTSHCGTDEVESNPQRAAIFTPHKESRMRWSADCRQIAVKVGKELLDSTLESLLGYPPDEVPEFSMGFDITSQPGRSWLNAVLLLREAIDNNAPDFVLRPLEELVVAQLVAAQPNNFTGRLTGAPRPPRPRTIARVIDFIEAEPGAAHTASALAAVAGTSVRSLQAAFTEHLGLTPMEYVRRVRLARCRQAFLTADPSDRQTVADIAFQNGFAHLPRFAAAYRKLYHESPSDTLRKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Q4</accession>
    <name>A0A231H4Q4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogen peroxide-inducible genes activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oxyR_2</name>
        <name evidence="3" type="ORF">B7C42_04052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781160.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43817">
        <property type="protein sequence ID" value="OXR43817"/>
        <property type="gene ID" value="B7C42_04052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="32231" checksum="6B6539A849BC52D8" modified="2017-10-25" version="1">MLDVRRLRLLRELAHRRTIAAVAEAVSYTPSAVSQQLTALEREAGVTLLERSGRRVTLTAAARRLVEHTEAVLAILEQAEAELATAELTGALHIGAFPTAVQRILPHALVSLSRAHPRLELHVTELDPAAVPAALRAGTLDIALIQEYDYVPAEPEAGLETEPFLEEPVYLAARTTQPLAAYREAAWISGTPGTLCHTMTVRACEAVGFVPRIRHRSDDFGTVLALVAAGQGVAFIPQLAIPLHPETDTTPVELTPLPIRRRTRIAYRAGTRTHPTISAARTALHATTGTIPPVDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4U7</accession>
    <name>A0A231H4U7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tuf</name>
        <name evidence="10" type="ORF">B7C42_04158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505815.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43919">
        <property type="protein sequence ID" value="OXR43919"/>
        <property type="gene ID" value="B7C42_04158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="43787" checksum="8F81551A12A93D48" modified="2017-10-25" version="1">MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLADKYPDLNQSFAFDQIDKAPEEKARGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKSDMVDDEEILELVEMEVRELLAAQEFDEDAPVVRVSGLKALEGDEKWVESVVELMNAVDESIPDPVRETDKPFLMPIEDVFTITGRGTVVTGRVERGVINVNEEVEIVGIREKTQKTTITGIEMFRKLLDQGQAGDNVGLLVRGLKRDDVERGQVVVKPGTTTPHTEFEGQAYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTEMSVKLIQPVAMEEGLRFAIREGGRTVGAGRVTKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Y2</accession>
    <name>A0A231H4Y2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetracycline repressor protein class B from transposon Tn10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tetR_10</name>
        <name evidence="5" type="ORF">B7C42_04170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43931">
        <property type="protein sequence ID" value="OXR43931"/>
        <property type="gene ID" value="B7C42_04170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22945" checksum="385AEB81442AD7C0" modified="2017-10-25" version="1">MQTSGGGNTLSEAEIVEAALRVVRADGVEKLSMRRLSRELGVSPMAPYYYVADKRELLDLVASAALTGVRTPPPEFGTWQQRLRELIDQIDEKLRKHPGLGDVLIEQTLGKQLDLIAAVMEILSDAGFEDRNVLAAYATIHTYLFGRARVNPRDRSALVDMPLPEAVERAVKHMGDLRGKYSYDFGMDVLIAGLEAQLVRQRDGHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Y5</accession>
    <name>A0A231H4Y5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43959">
        <property type="protein sequence ID" value="OXR43959"/>
        <property type="gene ID" value="B7C42_04198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="24904" checksum="42FB9469738692BF" modified="2017-10-25" version="1">MTKFVQTIEFKTSRLDEFNRTLDRWLTATEGTRSATHSMETRDRDHPDTYLQIVEFPSYEQAMANSALPETTGFAETLAALCDEPAVFRNLDLVREDDMDGAARTSLLVRNFDAADETREFESGSGRLEVVQAPSGAVGRAVFEPGWRWSTHVKPIAGTDSCQAAHIGYCVSGRMHIRMDDGTECEVGPGDFMQCPPGHDAWTVGDQACVMIDWAAAAEYARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H587</accession>
    <name>A0A231H587_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Thymidylate synthase</fullName>
            <shortName evidence="5">TS</shortName>
            <shortName evidence="5">TSase</shortName>
            <ecNumber evidence="1 5">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">thyA</name>
        <name evidence="8" type="ORF">B7C42_04217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 5"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776414.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43978">
        <property type="protein sequence ID" value="OXR43978"/>
        <property type="gene ID" value="B7C42_04217"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="7">
        <location>
            <begin position="10"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="30827" checksum="EDDF8C2E07522663" modified="2017-10-25" version="1">MDGAPGNDTQYEDLLRLVLERGTPKSDRTGTGTRSIFGHQLRYDLSAGFPLITTKKVHLKSIVYELLWFLRGDSNIRWLHEHGVTIWDEWADAHGELGPVYGVQWRSWPTPDGTHIDQIAQVLQTLRTDPDSRRIIVSAWNVADLDKMALAPCHAFFQFHVADGKLSCQLYQRSADLFLGVPFNIASYALLTHMVAQQTELEPGDFIWTGGDCHIYDNHLTQVREQLSREPYPFPRLHLRPAPSLFDYVFEDVEVLDYRHHPAIKAPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5W6</accession>
    <name>A0A231H5W6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low molecular weight protein-tyrosine-phosphatase Ptp</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ptp</name>
        <name evidence="4" type="ORF">B7C42_03788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777539.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44228">
        <property type="protein sequence ID" value="OXR44228"/>
        <property type="gene ID" value="B7C42_03788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="22310" checksum="99B7CAB9411AF894" modified="2017-10-25" version="1">MHVLFVCSGNVCRSVIAERLTRAVAAEHGLDDLTAESAGTRALVGFGVDPLAAQTITGLGADPGNFSARKLKPEMVARADLVLAMTEQIRDDIIDLVPNARSRTFTLLEAYRVAKVSGARTIAHIDSARNDLALVGRENIADPVGLSSEKYCAVGDRIAETLVPLLLALHAHRDAGRTTSGRPRLVLLPGGRIETPPWGIEPVRIGRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Z7</accession>
    <name>A0A231H5Z7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-degrading monooxygenase HmoB</fullName>
            <ecNumber evidence="2">1.14.14.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhuD</name>
        <name evidence="2" type="ORF">B7C42_03222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775732.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44433">
        <property type="protein sequence ID" value="OXR44433"/>
        <property type="gene ID" value="B7C42_03222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="11216" checksum="46CAFF3E0FEB6129" modified="2017-10-25" version="1">MAVVKINAIEVPEGAGPELEKRFAHRAHAVENSPGFLGFQLLRPVAGDNRYFVVTQWDSEESFAAWRDGPAKEAHAGQARQPVATGASLLEFEVVLDVAGKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6B2</accession>
    <name>A0A231H6B2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor KstR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kstR_1</name>
        <name evidence="6" type="ORF">B7C42_03243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517308.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44454">
        <property type="protein sequence ID" value="OXR44454"/>
        <property type="gene ID" value="B7C42_03243"/>
    </dbReference>
    <dbReference type="GeneID" id="66718585"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041642">
        <property type="entry name" value="KstR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17925">
        <property type="entry name" value="TetR_C_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="24057" checksum="B33E7A44D47ED8DA" modified="2017-10-25" version="1">MASPSREQAADSGAQNGARNRATVSTLSEDELSSAAQRERRKRILDATLALASKGGYDAVQMRAVAERADVAVGTLYRYFPSKVHLLVSALAREFEQFDSKRKPLAGQTPQERMHVMLTQVTRAMQRDPLLTEAMTRAFMFADASAAAEVDRVGKVMDRFFARAVNEGEPTERDLAIARVISDVWLSNLVAWLTRRASATDVAERLDLTVDLLLGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6K3</accession>
    <name>A0A231H6K3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent monooxygenase, oxygenase subunit HsaA</fullName>
            <ecNumber evidence="3">1.14.14.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hsaA_3</name>
        <name evidence="3" type="ORF">B7C42_03267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.12" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517284.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44478">
        <property type="protein sequence ID" value="OXR44478"/>
        <property type="gene ID" value="B7C42_03267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036383">
        <property type="term" value="F:3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="235"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="42711" checksum="F124EEEB86FD8DF3" modified="2017-10-25" version="1">MTQEVTERVEALLPKLREQAQEAEDLRRIPDETMKALQETGFFKLLQPRQWGGYAADPVVFYDTVRKIASACGSTGWVAGIIGVHNWHLALFDQQAQEEVWGEDTQVRISSSYAPMGAGVVTESGDGYIVNGSWAWSSGSDHATWTFVGGPVIKDGKPVDFGSFLVPRTDYRIDDVWNVVGLKGTGSNTLVLENVFVPRHRFLSYKSMNDLTAPGLQQNTDPVYKMPWGTIHPTTISTPIVGMAYGALDAHVEHQGKRLRAAYAGEKAKDDPFAKVRIAEAASDIDAAWRQLSGNVADEYKLLVAGEEIPFDLRVAARRDQVRATGRAIASIDKLFESSGATALANGTPLQRFWRDAHAGRVHAANDPERAYMMYGTHAFGLPVTDGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6P1</accession>
    <name>A0A231H6P1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein ZapE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zapE_1</name>
        <name evidence="3" type="ORF">B7C42_03251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44462">
        <property type="protein sequence ID" value="OXR44462"/>
        <property type="gene ID" value="B7C42_03251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="350" mass="38105" checksum="B2F7EC68ED169F2C" modified="2017-10-25" version="1">MDGLVLDGDQRAAAAALATVAERLSGRRWAFPRGFGSHALPTRSRPAARGVYLHGRPGRGKTMLMDEFFERVDSTRKCRFHFHQFFARFHTAIAESGGPPAALDALLGDTELICFDEFHVHDVGDAMLLTSLLQALFARGIVLVATSNYPPEQLLPNPLTHAKFEPAIALLRTHLAVVAVDGPQDYRARECRGRICDRTGFASGRYVRGHRPGADRPAAVPIAHLLLRARAAEADLLVVDFGEICGKPLSAIDFLTLTHTYRRWVVCAVPPLRRVPVDAVTRFVNLVDVLYDADLPLTLYTEVSLPELVRDVAAAPDLARTASRLVRLPGARPASVAEPDGPAGSMADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6R6</accession>
    <name>A0A231H6R6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RCS-specific HTH-type transcriptional activator RclR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rclR_1</name>
        <name evidence="5" type="ORF">B7C42_03271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44482">
        <property type="protein sequence ID" value="OXR44482"/>
        <property type="gene ID" value="B7C42_03271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="199"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="32948" checksum="0D369910D5497CEF" modified="2017-10-25" version="1">MGQCVDILSETVAAVRTGLPASGLFVRHAPWGRRYPLVPGAGFHIVLQGECWLLAPESEPVAMGPGDVLFMPRGAAHVIADSPHSAITEVATPGEPREIPGPGSRTTLLCGAYEVSRSRRHPLLDQLPDFLHLPADPDRSPALRAAVDLLVGELTEPRPGTDAAVPALLDTLLLFVLRSWYEQAETSGWAGAFADPAVSATLRAIHAEPARAWTVPELSAMAGVSRATLTRRFAATVGEAPLSYLTRWRMLTAARLLRETDLPIAAIAHRVGYGSEFAFAKAFKREYTLAPGRYRRAEESPPVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7R2</accession>
    <name>A0A231H7R2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 107B1</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777146.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44830">
        <property type="protein sequence ID" value="OXR44830"/>
        <property type="gene ID" value="B7C42_02784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="45833" checksum="C46DE7464883F5CB" modified="2017-10-25" version="1">MSTPPSDLAAAPGCPVHQAGTPFDADGPRIVLDTPAFVADPHRAYEAMRRRFGSMVPIELAPGVPATLVIGYHTALRILNDPDHFPADPRAWERTVPADCPVRPIMEWYPNVIRSAGSAHARYRQAFTAAFDRVDLHELHTTVEKIAIPLINEFCESGSADLVSQYAFPLAFEVLNRMVGCSADLGRRVATGMAAIFDTVNAAWGMDHMSQALMEQVQLRRAAPADDVTSHLAHHPAKLNDEEMVRNLIVFYGGGIEPQQNLISNTLLLMITDERFGGDILAGSLSTRDALDEVLFTDPPLANFCMTYPRQPILIENTWLPANQPVIISLAACNNDPEIAGGDRTGNRSHLAWGAGPHACPARSVAYLVVQDAIDQLLDALPEIRLAVDPSEISWRPGPFHRSMTALPVTFPPSPRLQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7R5</accession>
    <name>A0A231H7R5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777143.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44832">
        <property type="protein sequence ID" value="OXR44832"/>
        <property type="gene ID" value="B7C42_02786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="32541" checksum="F557540FB3C33291" modified="2017-10-25" version="1">MVDISSTLPRRQLGRYLRELRQGSGLTIAELARRIERGATTVQRLETGTADRIRLWDVDAICQVCGADDTTTEALKGLAQQGNSKSWWHQYGDLIPVSFDVYMGLEAAAAKLISFQELIPGLLQTPDYARTVTRQAHPSESDGEISRRVEMRVRRQVLLTKKSDPVPADIILDESALHRVIGNRRIMDAQLRYLADAGTRPNIRIRVLPFAAGLPLGDLTGPFTILSFGESGDGRPVEPPVVYAEGYTGAMYFDDADLVRRYHRAHAALGQVALDEQDSRKLLRDKAREFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7S2</accession>
    <name>A0A231H7S2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44766">
        <property type="protein sequence ID" value="OXR44766"/>
        <property type="gene ID" value="B7C42_02720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="55" mass="6066" checksum="7FCBE43794317D52" modified="2017-10-25" version="1">MIHTHAHPSFLGTLRTYARRALARHTLTAEERRNLAAAQAHPAVYSASLGSHPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7T9</accession>
    <name>A0A231H7T9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036499828.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44919">
        <property type="protein sequence ID" value="OXR44919"/>
        <property type="gene ID" value="B7C42_02875"/>
    </dbReference>
    <dbReference type="GeneID" id="66722015"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="55" mass="6211" checksum="965E7C9C3C6BFA8E" modified="2017-10-25" version="1">MGAEEVKQFNVYLPVELIKQVKYRAVESEMSLSALVAEALRAYLGAEPPTREKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7V9</accession>
    <name>A0A231H7V9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pitA_2</name>
        <name evidence="7" type="ORF">B7C42_02884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44928">
        <property type="protein sequence ID" value="OXR44928"/>
        <property type="gene ID" value="B7C42_02884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="427" mass="44329" checksum="6B1771FE14992E8F" modified="2017-10-25" version="1">MSRGLWAPPAHRTITRVNSELIILLLVIVTALAFDFTNGFHDTGNAMATSIATGALKPTTAVTLSALLNLVGAFLSVEVALTVTNAVIRIQNKDGTPKAEFTADHGRALLIIVMAGLIGGIIWNLLTWLLGLPSSSSHALFGGLIGAAIASGAGVVWIGHGKIDGVVGKVIMPALFSPVIAGIVAAVGTFLIFKIVVGIGERFTEAGFRWGQIGTASLVSLAHGTNDAQKTMGVITLALIGYSASDPQSTGPFAWHETDNVPLWVKFACAAAIALGTYIGGWRIIRTLGKGLVEISSPQGMAAEASSATIILASSHLGFALSTTHVATGSILGSGVGKPGARVRWNIALRMVAAWVITLPAAAVVGAVMWVIAAKIPTLLGPLIAFAILCALSVYMYRRAQLQKVDHTNVNAEWDEPVAPADTIAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H899</accession>
    <name>A0A231H899_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45164">
        <property type="protein sequence ID" value="OXR45164"/>
        <property type="gene ID" value="B7C42_03122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="32186" checksum="EE6AD1171A39D88B" modified="2017-10-25" version="1">MSGKLALGALTAPVPGLDQRPVGLNASGAAWIFTLVISIGFVAIAVWCLWFAVRRKDVLPLIMLGSGLLSVGLESIVDTLGNVWYANDNPWVVYTALGVPQPAFLILGYSLFWGGTVYVGSRFVLRGTSLWLIFATVFAMDLFVEYLGAPILHVGQYFGFSPYNLLGFPVWWAFVNGAVASVGVWLLIVLERRLRGWRRVALLVISPSAFAATHACCAWPVWVVLHADAPRWAGWIAGTTTIALAFGVVAFAAAMISDDLQRAIGYEPECAGSDTADRAVDRKMSKLTDVASSAVATTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8C4</accession>
    <name>A0A231H8C4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe(3+)-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fbpA_5</name>
        <name evidence="4" type="ORF">B7C42_02319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45194">
        <property type="protein sequence ID" value="OXR45194"/>
        <property type="gene ID" value="B7C42_02319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167060" evidence="3">
        <location>
            <begin position="31"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR002825-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="36195" checksum="7DA4B83958318A82" modified="2017-10-25" version="1">MAAAQQHERRWKLVLAVVALAASAMITACSASSDEPEIVVYNAHDQRLTRQWADAFTEQTGIRVTVRDGADAEVADQVLAEGDRSPADVVLTENSPAMARMERAGLFAGLDPTTLAQVPEQFRPSSGQWTGIAARSTAFVFHPGKIPPAELPAGLLDLQQPRWHGRWTADSHGADFQAIVAALLALDGEDATRAWLQGVKDNATVAPNGFAALKTVGAGGVGGALVFATDWYRDQLAPERIIGPSAPHYFRGGDPGGYLSLSGAGVLKSSRHAADAQRFVRFVTAAAGQRLLSGGAAMEYPVAAGVPADPALPPLDSLDPPRVNPSDLDPERVEALMREAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8S6</accession>
    <name>A0A231H8S6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crt_3</name>
        <name evidence="3" type="ORF">B7C42_02327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45202">
        <property type="protein sequence ID" value="OXR45202"/>
        <property type="gene ID" value="B7C42_02327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="38254" checksum="E5AFDA452FB244FB" modified="2017-10-25" version="1">MTEAEVLFDKRDGVGLITLNRPKAINALNHPMAQAILSTLREWADDDEVRTVVLTGAGERGLCAGGDIVAIHTDAKNAVAHGVSRRDSADSPSGRFWRDEYILNALIGNYPKPYVAVMDGIVMGGGVGLSAHGNRRIVTERSMVGMPETGIGFIPDVGGTYLLARTPGELGTHVALTTARMGAGDAIAAGFADHFVPAERIPDLLAQLRRTDADAAIAAVAQPAPVSDLAAQRSWIDACYSADTVEEIVARLQRHDAPEAAKAAGDVLAKSPVALKVTLRSLRNARRAANLEQALDEEYRVSVAALTTHDLVEGIRAQVVDKDRNPQWSPATLAEVPDALVDSYFADLGDRELGLSGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H978</accession>
    <name>A0A231H978_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063906176.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45573">
        <property type="protein sequence ID" value="OXR45573"/>
        <property type="gene ID" value="B7C42_02698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011315739" evidence="1">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="98" mass="9335" checksum="C82AEE779B195788" modified="2017-10-25" version="1">MLRTAGFIGAAALAGLVTVLAPASANAATGSLGINSRIIGNPSGCIQVNGSPLMANSVANYTDRDATVFSNADCTGDVTGTVPAGAVGAANGGSIQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9E6</accession>
    <name>A0A231H9E6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="2">2.1.1.166</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rlmE</name>
        <name evidence="2" type="ORF">B7C42_02603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45478">
        <property type="protein sequence ID" value="OXR45478"/>
        <property type="gene ID" value="B7C42_02603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="651" mass="68179" checksum="79FC12B5DC521163" modified="2017-10-25" version="1">MAPDPTTPVATGNPWPALSDYTKNHTSGKDALKFEPDVALEVAAAAESTIAALKTLQLYTDDLTAGSPVSNLASGTALGKKFGTEATDLKTVFEDHKTILGQMIDTFIAAGKAYGKMDGFNSALLDNVSGKPDYMWDADGLDPMGDPPKVPGTTDDMKNPVNAMDNKAGLQSFQSSTISPEAPDYMSWYDLFQVGNYIRVNKVAENLANHAGTWWWMATEVNKVYSDLLNKIDSVTVDKWSGPGKETAVAAVQAYGKSIPGLSTAIRGTGDLLVYSSGWLNETQYSMPPNNDADAKTQQQWIQTVRESFRRTYVFGMNQSSSHVPVLPAAAAAFGQIPANPYNPTGQNPPGSQNPPGSQNPPGSQNPPGGSTPPGGSTPPGGTTPGGGTPNDAQAKAAQEAAARQQREALAQQQKQAADFEKQQKEAQQQQQKEQQQQQQQQEQQQKQQEQLQKQQEQQQVAAQQQQQQQQVMSAVQQLMSAAQQGAQQLMQAFQQVAQTLTQQQQQDALAKAGLGDIPGLNIPGMDGSDPLSALAGAGGGAGGGGGGVPGGGAGVPGMPALSRDLAQASKLFPRASTLSTALSANTVDSATGRAGAAPMAGTPGSPGAAGAGAQNQQGKEHKRPAYLDSVEHLEDALGDAPVVVKPVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9L1</accession>
    <name>A0A231H9L1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776482.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45520">
        <property type="protein sequence ID" value="OXR45520"/>
        <property type="gene ID" value="B7C42_02645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="12052" checksum="677ED24C5914A0B2" modified="2017-10-25" version="1">MFALVVRFDLENEEKATAFDALVAETVRTITAKEPGTLVYATHTVVDEPLSRIFYEVYRDREAFNEHERQPHTRRFLEQRSEYVESFRVEFLTPTAAKGPAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9V0</accession>
    <name>A0A231H9V0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45743">
        <property type="protein sequence ID" value="OXR45743"/>
        <property type="gene ID" value="B7C42_02035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="21145" checksum="8B85F8533D3D2F93" modified="2017-10-25" version="1">MRRYPSLALRAWRTGPWAPNRLMRPSDRIEAVVRILAVAVVLAAVPICAAMGTARYTDAAVQIRGENAAKTAVTATIVTDPVRTTATSMDVSADRYEATVRWTHDGRSGEATAPVAAVAHPGQQLTMWLAPDGRPTAAPLPADTAAMRGVGLGMATFVEICFATAALVWLTAWGFSARHRAGWAREWRNISRPIGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9W9</accession>
    <name>A0A231H9W9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_5</name>
        <name evidence="1" type="ORF">B7C42_01894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783982.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45602">
        <property type="protein sequence ID" value="OXR45602"/>
        <property type="gene ID" value="B7C42_01894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="28338" checksum="447398047A9C55B3" modified="2017-10-25" version="1">MGKLDGKVALVSGSGRGIGREIALKLATDGAAVVVNDLDAEPAKETVAAVEAAGGRAVACVGSVTDEDFAERFVHTATDTYGGLDIIVNNAGYTWDSVIQKMTDEQWDAILDVHLKAPFRILRAAQPVISSAVKQARQAGADVPCRKVVNISSLAGVGGNAGQANYAAAKAGVTGLTKTLAKEWGRYNVTVNSVAFGLIKTRLTEAPAGGDATIDMAGNRIKVGVNPDVLSAMESGIPLGRAGTPQDAAGSVYLLCIPESDYVSGQTLVCGGGFMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Y5</accession>
    <name>A0A231H9Y5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45773">
        <property type="protein sequence ID" value="OXR45773"/>
        <property type="gene ID" value="B7C42_02065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="80"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="429" mass="47891" checksum="AA60DC82052EF21F" modified="2017-10-25" version="1">MSTADIFVIGLDDGNLRTLELIPDAPQFRFHRLLGIEETQEGEIPIEDLLHKAEEALKGFDGDIAAVVGYWDFPVTALVPMLCERFGLPSADLEAVVKCEHKYWSRIEQSKVIDEIPKFGIVDLDGEPRLPEGMTYPVWLKPIKSFSSELAFHVHDDREFEAAVEQIREGVGRVGKPFEFVLDRVDLPPEIAAIGGQACLAEETLTGVQAATEGYVYRGQVTVNGALDSINYPDTPCFLRHQYPSQLPSEIVARMTDISERVISRMGLDNSTFSIEFFCEPDTGRVSVLEINARHSQSHADMFYAVDGVPNHHCMVRLGLGLDPRLPKGQGRYDIAAKCYYRRFSDGIVTRVPTAAEIERIQDEIPGVTIEVVPAEGIRLSEMPAQDSYSYELADIFIGADSEADLVDKYERCVAALHFEFDDVDDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA20</accession>
    <name>A0A231HA20_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45652">
        <property type="protein sequence ID" value="OXR45652"/>
        <property type="gene ID" value="B7C42_01944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012466499" evidence="2">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="93" mass="8794" checksum="DF248A2FB561B108" modified="2017-10-25" version="1">MVSRKILAAATLSAAALFVGPAAMASAAAPSADSTTPAPAQLSSGSADSGSASSGSATLDSGSSALDEGTSTIDNIITAITGIRDLSQPKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA94</accession>
    <name>A0A231HA94_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782436.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45873">
        <property type="protein sequence ID" value="OXR45873"/>
        <property type="gene ID" value="B7C42_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="104"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="363" mass="40373" checksum="27A2DB90068F3404" modified="2017-10-25" version="1">MITLPDGGTSPLIDASVHIFFQGNAELRGWLREPYSARGYPDVEMDWYGAPGGEYAPGTVLSEGGYPGSEPDAVGQVLFGERGADIAILHPMTRGIMPDRHLGTAIASAHNEMMIARWLDSGAYADRYRGTLRVNPEDISGAVREIERWGSHPRVVQIGIPLQSRELYGKPQFWPLWEAAADARLPVAVHIETGSGVAYPPTPSGHPRTYEQYLGFMALNYLYHQMNMIAEGVFERFTELRFVWADGAADLLTPMMWRMDTFGRPHLEQTPWAPRMPSDYLPGSIYFVQGRLDGPGDVDFAGDWLEFTGKDDMVMFGSSYPHWQLDDPARLPSALTPAQREKVLWRNAAGLYGIDIPAAATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC7</accession>
    <name>A0A231HAC7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor MprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mprA_1</name>
        <name evidence="2" type="ORF">B7C42_02205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45913">
        <property type="protein sequence ID" value="OXR45913"/>
        <property type="gene ID" value="B7C42_02205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18455" checksum="B340A70EAB85958F" modified="2017-10-25" version="1">MAGRQTDAVDAIVAQWERERPDLDLTAMAVLGRLGRLYVLAEREIDAVFTAHGLQRGEFDVLAALRRSGEPFELTPSVLADTLMLSRAGMTGRLDRLESAGLVRRIADRADRRAVRVALTEAGRARVDEVVTAHTENETRLLSGLSARDRGELDRIARLLLADLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAE2</accession>
    <name>A0A231HAE2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45923">
        <property type="protein sequence ID" value="OXR45923"/>
        <property type="gene ID" value="B7C42_02216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="70"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="36439" checksum="A6E7ED92E4B77B43" modified="2017-10-25" version="1">MSGASDSVAPVTNSAHVPAHPDSAPPSFRSGDLRDPRLSAALKTLELTVRRRLDGVLHGDHLGLIPGPGSEPGDARMYQPGDDVRQMDWSVTARTTHPHVRQMIADRELETWLVVDLSASLDFGTALCQKRDLVVAAAAAVTHLTSGGGNRIGAVVANGERLYRIPARTGRVHAQSLLRSIATTPHASDGVRGDLRGAIESLRRPQRKRGLAVVISDFLGEIDWQRSLRAISGRHDLLGVEILDPLDLDLPDVGDVVLHDPETGRTREFSVTPTLRADFGRAAQQHREQVEAALRSCGAPVMTLRTDRDWIADVVRFVSTRRHTFGAPTGRVPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAN1</accession>
    <name>A0A231HAN1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain type dehydrogenase/reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45787">
        <property type="protein sequence ID" value="OXR45787"/>
        <property type="gene ID" value="B7C42_02079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="31785" checksum="BEA966A545F60690" modified="2017-10-25" version="1">MSELRFDDRVAVVTGAGRGLGRAYALLLAERGARVVVNDPGGSMRGEDPDAGVAAEVVAEIAAAGGTAVACTASVATPEGGRAIVDTALDRFGRLDILIHNAGTVRYGSLTELSYEDFEAVLDVHLRGAFHTVRAAFPVMSAAGYGRVVLTSSIGGLYGNRAVANYAVSKAGMIGLSNVVALEGAEAGVRCNIIVPSALTRMADGIDTSAYPDMRPELVAPAVAYLAHETCCLTGELLVAIAGRVARAYIAETPGVYQPSWTVDEVAARIDDIRNTDNSWILPPLSAHADHIGRSFAMATEGKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAU2</accession>
    <name>A0A231HAU2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Soluble epoxide hydrolase</fullName>
            <ecNumber evidence="5">3.3.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46064">
        <property type="protein sequence ID" value="OXR46064"/>
        <property type="gene ID" value="B7C42_01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="41802" checksum="73ACAC9F9255E792" modified="2017-10-25" version="1">MTIRPFHIDIPQDRLDDLADRLRRALWPDELPGVGDAYGVPGDRVRALAKYWLNDFDWRATEARLNTHPQFRTEIDGEDIHFLHVRSSRPDALPVILTHGWPGSVLEYLDVIEALTEPESPDHPAFHVVLPSLPGFGFSGPTRSTGWDTQRTARAWVELMDRLGYQRFGAIGNDGGSMISPEIGRLAGDRVVGVHVTQLFSFPSGDPAEFDGLSEEDLGALAHLQWFQDNKMAFNILCSQQPQTLAYALSDSPLGLLGWNAQLFGEGLDPEFVIGNIALYWLTGTAASSIRFYYENAHATERPSGPTTTPTALAMFAGDFRSIRRFAERDHENIVSWNSYDVGSVTGGPNDAAGHYAAHEAPEVLVGDIRTFFARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAV1</accession>
    <name>A0A231HAV1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold shock-like protein CspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cspC</name>
        <name evidence="3" type="ORF">B7C42_02271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45978">
        <property type="protein sequence ID" value="OXR45978"/>
        <property type="gene ID" value="B7C42_02271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13775" checksum="147E86AA105000EB" modified="2017-10-25" version="1">MSIGKLVSFDSSRGFGFIRPEDGGPDVFVHVNDIGLDEDELRQGRVFEFEVTEGDRGPKAVNLTAVGGAPAPPRHRGRGTGQLTAAEHKRLITELLLDASPALTAGEIITIRDRLAEFADQHGWLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAZ6</accession>
    <name>A0A231HAZ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781315.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46028">
        <property type="protein sequence ID" value="OXR46028"/>
        <property type="gene ID" value="B7C42_00991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16553" checksum="77AAF0202187B853" modified="2017-10-25" version="1">MPNTLEATIDISAAPDKVWAVVSDLGRMPEFSPTTLKMIPLGTPRAGTWTVNLNKVGRKYYPTTSRIVRYEPNQAFAFRMNENATVWSYTLEPTAAGTRVTERRDVPNGVRKPVRLMIDALLGGEQRFEADLVAGMNETLGKIKVAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB08</accession>
    <name>A0A231HB08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na(+)/H(+) antiporter subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mrpG</name>
        <name evidence="2" type="ORF">B7C42_01004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063013011.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46041">
        <property type="protein sequence ID" value="OXR46041"/>
        <property type="gene ID" value="B7C42_01004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="118" mass="12828" checksum="578B8B305224D96A" modified="2017-10-25" version="1">MSGLFHTALIWLSYGTILLGAFLAATAAVAIVRFPDTLSRMHAATKPQVVGLILMLIGSAIQLRGHPNVWMLVLVGLFTLVTAPAIAHLVGRTAYREQRHRDGLLLINEMGDEDLPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBH9</accession>
    <name>A0A231HBH9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043405.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46208">
        <property type="protein sequence ID" value="OXR46208"/>
        <property type="gene ID" value="B7C42_01173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="22300" checksum="7D65F7B61468FAC3" modified="2017-10-25" version="1">MTVTGSVPGPLSEPTPGGPGFRTNPATQIERFHHPTTRSLLSGEGFTTTALEHILETTLSVHVLRQQQVPPRTLPTFIVDELRLQDAEGALVRRSRLVTPALATVSINYVVAVPQSAAASGIDDVRMPIGHGLLTRGLPQRRRLLWAGIRRWPDGRPSASRAYIMTLGRHPVCYIREVFHPAVVPPAYTTGPEPALRDDVSEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC05</accession>
    <name>A0A231HC05_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46227">
        <property type="protein sequence ID" value="OXR46227"/>
        <property type="gene ID" value="B7C42_01193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012443793" evidence="2">
        <location>
            <begin position="30"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="446" mass="47320" checksum="1EBA98E6F04504F4" modified="2017-10-25" version="1">MRKYTLAAMTALALVCAAAGAGVSGTAAAEPVPPQTPTLNEVFNGFVVGSLQGASPASPREAFDALRADDPFYREPPLTGAEKPGTVLKAKKVDVLFTGVKPANLDAWKLMYVTTERDGVTPAISTGILMIPRDGKPANERHVVSYQEANDSVGWNCHPSTQWTGGDPLDGASWSALGPLALMFGKGYAVMISDVGNDADRARHGVFAGKYAAHTQLDGTRAALNFGDAGLNPRAQVALFGIAGGGVGAGFSAELQPSYAPELNVKSTVLEGMVVDQRNFMRVADGSVGSGFAFATLLGLEPKYPEMQLDSKLNSAGQTVAKIFRGQCQDAYFSMPFVPLRAMFDSGLNPADEPAFQPVFDDNRLGRSGAPASKVLIASCAKDDSPMSLVPAADSRELADTYRAQGTDVTYQPTDCSMVKMLTDLYGWGTDLFGMQTIDWMDRQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCB8</accession>
    <name>A0A231HCB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041737.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46541">
        <property type="protein sequence ID" value="OXR46541"/>
        <property type="gene ID" value="B7C42_01511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="187"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="309"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="600" mass="63563" checksum="2155B696FD48B330" modified="2017-10-25" version="1">MVMARTTGAFYVMGGVLGLLITAIAPGDEGNRPLVGSAALVALLLGVSLLIWGPRQPHWVHHGYVAVATVLVTIAVHWFPNTVGAITLAAFYVFVAADAAIFFAWRLAGAHVAFAVVLCLWVVPSRGLPWWSGIIPAGITVGVGIVVGILTRMASDADIDTLTGLLNRRGFDRALSSAIGHAGRTGQGLALVLVDLDRFQKINDHLGHRAGDAVLQRVGDTWSKLLGPDQLLARYGGDAFALLLPNTTEQAAILLTEQLRAAVTTGCSAGVTSWQPGESGSLLVSRADVGLYRAKQAGRNRTVLESSRQLPLAVELREAIDTGALDVHYQPIVSLGEDGAQAVGVEALLRWSSNAQPDVTTEGLIRVAEEYDLISDLDELVLRRACADAARLQQTFAQLDLTLNVNVSGLELAESNYADRVSGILADTGWPADQLVLEVTESELAAESQTAIANLHQLRDSGVRIAIDDFGTGYSSLSRLATIPSDILKVDQSFVAAIRSDSPAPPLLGVIAALSKSLDLQVIAEGVETEYQAAVLTELGFALAQGYHYSDSHPVSELISDMNSNRGLVGAGATDRELAAKGWIPVDNNGFDPEGSIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCC6</accession>
    <name>A0A231HCC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46551">
        <property type="protein sequence ID" value="OXR46551"/>
        <property type="gene ID" value="B7C42_01521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16227" checksum="51844B3856537852" modified="2017-10-25" version="1">MPIVLGLPALDANSKGFVDAFNSVPTDGLNQAVDRLSVIIATRAEIAFGDKPGALTYEKSPKHGKNQRGNAAPEPTHGQETLEESVLIKPTTSRRVGFDPDTGEFDVFDETYPESGIYHGHQRSWDQLSPDMQNALVNAGIVDRKGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCL2</accession>
    <name>A0A231HCL2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactofuranosyl transferase GlfT2</fullName>
            <ecNumber evidence="3">2.4.1.288</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glfT2_1</name>
        <name evidence="3" type="ORF">B7C42_01540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.288" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46569">
        <property type="protein sequence ID" value="OXR46569"/>
        <property type="gene ID" value="B7C42_01540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045699">
        <property type="entry name" value="GlfT2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040492">
        <property type="entry name" value="GlfT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19320">
        <property type="entry name" value="GlfT2_domain3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17994">
        <property type="entry name" value="Glft2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glft2_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="GlfT2_domain3" evidence="2">
        <location>
            <begin position="451"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="651" mass="72317" checksum="485D4E2CCB880048" modified="2017-10-25" version="1">MTAQVTLEDMSTETRAKSLLQRIILPRPGEPLDVRTLYLEESATNARRAHAPTRTSLSIGAESEVSFCTYFNAVPASYWRRWTILESVVLRLDLSGHGRVDVYRSKADGSRIHVRGNEFATTTAGRESITAPTDVTTVEFEVELAPFEDGGWIWFDITTDSAVELRSGGWYAPIEAPGEGSIAVGMPTFNRPTDCVNTLAALGSDPLVLEKIAAVIIPDQGNRKAVDEPGFAEAAAILGDRLAIHDQPNLGGSGGYSRVMYEALKTTDAQYIVYMDDDIEIEPDCILRALAFARFSRTPTLVGGQMLNLQERSHLHTMGEVVDRGIWMWTAAPNVEYDHDFSKYPLRDRDNSKLLHRRIDVDFNGWWTCVIPRVVAEQIGQPLPLFLKWDDVEYGLRARAAGYPTVTLPGAAVWHMAWSDKDDAIDWQAYFHLRNRLVVAALHLGNDGRPMIVNTVKATLKHLLCLEYSTVAIQNQAIRDFLAGPDKLFELLPTALGQVAAMRKEFPDAVIVGSSTDLPLPSGADVGAVGEPSNPLAKVVRLGKGVVHNLRKAKTEHHDRPQLNVPTLDARWFLLSQVDGVTVTTADGRGVVYRKRDPRQARELFAEAMRLRRELAARFPELRERYRAAHARLTSTAAWENAFGINTSEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCQ4</accession>
    <name>A0A231HCQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46609">
        <property type="protein sequence ID" value="OXR46609"/>
        <property type="gene ID" value="B7C42_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="27660" checksum="9D161BD0043BF4C6" modified="2017-10-25" version="1">MSNPYGGQPPYGQPFPPNGAQPYPPAQPYPGAPQPNGPYGAPPPHGGSGAVAAPGYPQPHAGSQPHIPQPHNVSQPHHAPGWGAPQAPPQPYGQPPANPYGAQPYPGQQPFNGGPAPYGAPNPGAPQGQYGAYGPAVQFQPQPGPQGIVVDASYFPLGFMLALTGPKILVDGMEVPMAKWGQTHIPVGPGQHHVRVATKWLWDMGPAETAVPVAEGHSTHVYYKSPAIAFINGAIGPVPQAAPGAIVSYISLGVVGVLILLQLLIACTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCU4</accession>
    <name>A0A231HCU4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46517">
        <property type="protein sequence ID" value="OXR46517"/>
        <property type="gene ID" value="B7C42_01487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="189" mass="21058" checksum="FDD3740CAE2BD89D" modified="2017-10-25" version="1">MTDWNTLLREQIDRHWTDQIRPRLDGLTDDEYFWEPVPDCWNLHPRGAGNAPIQGGSGAMTIDFAFPPPDPAPFTTIAWRLGHVIVGVLAVRNASHFGRAATDYHSFEYAETAKDALAQLDSEYAGWLDGIGSLGEDGLARPCGAAEGPYAELPFSALVLHINRELIHHLAEVCLLRDLYLHRNRQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCU9</accession>
    <name>A0A231HCU9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775202.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46595">
        <property type="protein sequence ID" value="OXR46595"/>
        <property type="gene ID" value="B7C42_01566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="32637" checksum="E6A47D38BB8D5A0D" modified="2017-10-25" version="1">MASPQGITGSTMPRRQLGRRLRDLRNRARMTTRVAARRLEWSEAKIWRIETGQTSLRSLDVEAMCKIYGAPEAELEPLTALARETKARGWWAPYGDVIAEGFDVYIGLEEAATHISTFENEFVPGLLQTEEYTRALLTAARPNLSPAEVERRIEVRRQRQRLLTRTPDPVRLVAIIAESLLWRRIGDPAVIAGQLDHLRRMCEFPHIDIRLVPNDSGYHEGLDSGRFVLLEFGEADAETTEPPVVYVENFAGSTYFDKNSDIDRYRGAFANIRAASVDGRAVLDEAIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD65</accession>
    <name>A0A231HD65_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46647">
        <property type="protein sequence ID" value="OXR46647"/>
        <property type="gene ID" value="B7C42_01621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="9147" checksum="A5262F94670E1952" modified="2017-10-25" version="1">MAVTEQGCIWCGHDEDSHSAIFGECLRMTEDALGASEWCKCREYQAPSKLDGSLWRMAGLVVGAGWDFLVAKFAGYVEGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDA7</accession>
    <name>A0A231HDA7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46776">
        <property type="protein sequence ID" value="OXR46776"/>
        <property type="gene ID" value="B7C42_01754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234771" evidence="1">
        <location>
            <begin position="31"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="42634" checksum="09E777FC80D2722A" modified="2017-10-25" version="1">MTRIARNLRRVAATLVATSVGVGAASTASAAPLPTFPIGAPEYTVDVNTPGAAPGYIYYSNGVSAAALVPGAGKALSDVPATAPANIVVDKAGHEVWRYTPPAGQDVSNFRTQTYQGKRVLTWWQGGTVGGHGSGADYIADEHGNVIETLDAGGAPSDVHEFRLTPDGRALITSYQEVDADLSAIGGPKNGTMYDTVATVVDVATKRVLLRWSAAEHVPLTDTTTPGKLPGSDTYDPYHMNSIALDPDGNLVISMRDTSTVYDVDIHTGAINWQLGGLHSTFDLGPGVAFAFQHDAEFADPSTLRLFNNNSSGFQTLGVSSVQWIHLDPADHRATLVRNQTHPDGLTAFAMGDAQPLPNGNTLVGWGMAPHISEFGPTGDMVYDARLPLGTYRAFPADWAPTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDR3</accession>
    <name>A0A231HDR3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.121</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppzP</name>
        <name evidence="4" type="ORF">B7C42_00142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.121" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47024">
        <property type="protein sequence ID" value="OXR47024"/>
        <property type="gene ID" value="B7C42_00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13931">
        <property type="entry name" value="PT-CloQ_NphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020965">
        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036239">
        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11468">
        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01163">
        <property type="entry name" value="II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="SSF143492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="33177" checksum="0C129B5F81568C5B" modified="2017-10-25" version="1">MSTTTESALDDLYVAIEKSARLANVPCTRDAVWPVLTAFGTMLTRSVISFRVVTEARRAGDLDYRFLTLPKDIDPYDIARSNGLIRQADHPIGSLLDQVREQGPVDSYGIDVGVAGGFKKIWPFFPADDVRNVAELAALPSMPAGLADHAGMFARHGLADKVGLLGIDYHDKTMNVYFPGLPAEHFAPEAVAALHRDAGFPKPSAQFLALTAKAFDIYATFGWESSRIERLCFPVITPDPAALPIPIDPRFQELADNAPFATNDRRFTFAATSSPAGESYKFSWFYQWQPRILDKMKTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE25</accession>
    <name>A0A231HE25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase RecQ</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">recQ_1</name>
        <name evidence="3" type="ORF">B7C42_00313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47191">
        <property type="protein sequence ID" value="OXR47191"/>
        <property type="gene ID" value="B7C42_00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="245"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="715" mass="78013" checksum="E5463B2A8BB58243" modified="2017-10-25" version="1">MERVTTTELRESAESLLRELAGPEARLREDQWTAIEALVVQRRRALVVQRRRALVVQRTGWGKSAVYFIAARLLRSQGRGPTVIVSPLLALMRNQVAAARRAGVIAATINSGNVTEWDEIHQRVAAGEVDVLLVSPERLNNPDFRDSVLPKLAADAGLVVVDEAHCISDWGHDFRPDYRRIRTLIADLGEDIPVLATTATANNRVVTDVATQVGTDTLVLRGTLDRESLRLSVVRIDDAVQRTTWLSRQLGELPGSGIIYTLTVAAAHDLADVLSDHGYPVAAYTGRTEPGERETLEQALLDNDVKALVATSALGMGFDKPDLGFVVHVGAPSSPIAYYQQVGRAGRGLVPDASSPSGRAARAEVVLLPGPEDRRIWNYFASVAFPREQVVRSVLSALDYDRPMSTVALEPLVELSRSRLEMVLKVLDVDGAVRRVRGGWLATGEPWTYDTERYERLDRAREAEQQAMLEYQSTPECRMNFLRRQLDDPGLAPDAPGCGRCDNCTGRRFDTSVDAGEVATIRARLDRPGIDLLPRKQWPTGLSKLGVPLSGKITDGPEVGRVLGRLSDLGWGQRLRTLLDAPDGPAPDHIVDACIAVLREWKWTQRPGAVMALQSATHPALAADLAARLARIGRLTDLGVLHTRPDRPPVSAANSAHRVAALFDSWETPDLTGLDTPVLLVDTHTDTGWTLTLAARTLRHAGAPAVLPFALATPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE30</accession>
    <name>A0A231HE30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47144">
        <property type="protein sequence ID" value="OXR47144"/>
        <property type="gene ID" value="B7C42_00266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="177" mass="19503" checksum="571F527517697DE0" modified="2017-10-25" version="1">MRISVHGTGEGVQVRMRLDANRRRRLITRISLWLLAINGIVVGLWAVLLPEPWFRSFPGFGLNWVAMDGPYNHHLATDVGAFFLGFGALSLAALYYRGSVVARVAGIGWLVFGIPHLVYHAARKPEQMSGANFALSLIAAALLPALAAAVIVAAPRERVQLRDPAPMNIRFPRRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE41</accession>
    <name>A0A231HE41_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-ketothiolase BktB</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bktB</name>
        <name evidence="6" type="ORF">B7C42_00165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47046">
        <property type="protein sequence ID" value="OXR47046"/>
        <property type="gene ID" value="B7C42_00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="392" mass="40369" checksum="B33D1412E4CF05AF" modified="2017-10-25" version="1">MSHEAVIISGARTAIGTAYKGSLTDTDAFTLGTAAVAEAVRRAGVEPELVDDVILGESLYGGGAIGRYVAIEAGLVNAPGIAHNRHCASGLSTLQSAAASIIAGMDRIVVAGGVQSSSTAPKVNRRIPGSEEWEEDWLAPSHRESPDAPVRDMSITVGWNAAVKAGITRAQMDQWALRSHQRAVAAIDTGSFTEEIVPIEVTRRDGSTVTFAVDEHPRRTSSLEKLSSLKPLHPEIEGFGITAGNAAGINDAAGALVIADREVARERGIEPLAVVRAWASVGVPPADTGLAPAPAIEKVLARAGLLVADVALWEINEAFASVAVAATRALGLDEEKVNVLGSGCSLGHPVAMTGTRMVLSLVHELRRRGGGVGVAAMCAGGGMGTAVVVDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE63</accession>
    <name>A0A231HE63_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47102">
        <property type="protein sequence ID" value="OXR47102"/>
        <property type="gene ID" value="B7C42_00224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="57" mass="6373" checksum="F1F5098C6F1E1B0C" modified="2017-10-25" version="1">MEYVLGELADNSPEVRLIDDEELSEFRWVSAADMDELTGGTVFGPLREALVKKMDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEI2</accession>
    <name>A0A231HEI2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein YknY</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yknY</name>
        <name evidence="5" type="ORF">B7C42_00516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47393">
        <property type="protein sequence ID" value="OXR47393"/>
        <property type="gene ID" value="B7C42_00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="240" mass="25953" checksum="E5F23B6B19533DDD" modified="2017-10-25" version="1">MLELTDVVKEYRVGEQRVRALDAISLRIEAGEFTSIIGPSGSGKSTLLHLLGALDSPDSGSITFRGEEIGSLDDNRQSEFRRHRVGFVFQFFNLLPTLSAWENVAVPKLLDGTGLRKAKPRALELLDRVGLADRADHRPAELSGGQMQRVAVARALIMDPPLILADEPTGNLDSKTGASILELLGDISGAGNSVVMVTHDMGAVEYCDRVITLRDGRIGSNELVSARGREVHDGDEVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEJ4</accession>
    <name>A0A231HEJ4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">modB</name>
        <name evidence="10" type="ORF">B7C42_00463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47340">
        <property type="protein sequence ID" value="OXR47340"/>
        <property type="gene ID" value="B7C42_00463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="42"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="26848" checksum="E6BD23695B25C1B5" modified="2017-10-25" version="1">MLVLPALCALAFLVIPLIGLLVRTPWASLSDRLFSAEVGTALRLSLICATSATVICLVLGIPLAWLLARAQLPGRGLIRALVTVPLVLPPVVGGVALLLVFGRRGLLGQYLYDWFGVSLPFTTPGVVVAEAFVAMPFLVISVEGALRSTDTRYEEAAATLGATPWYTFRRVTLPAIAPGVIAGGVLCWARALGEFGATITFAGNFPGRTTTMPLAVYLALETDPDAAIVLSLVLLLVSVAVLVSLRERWIRGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEZ1</accession>
    <name>A0A231HEZ1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">serA</name>
        <name evidence="11" type="ORF">B7C42_00567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47444">
        <property type="protein sequence ID" value="OXR47444"/>
        <property type="gene ID" value="B7C42_00567"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="459"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR47444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="532" mass="55792" checksum="B7A0E82D41C040F9" modified="2017-10-25" version="1">MSQNGRPVVLIADKLAQSTVDALGDGVEVRWVDGPNRPELLAAVPEADALLVRSATTVDAEVLEAGKNLKIVARAGVGLDNVDVPAATERGVMVVNAPTSNIHTAAEHAVTLLLSAARQIPAADATLREHTWQRSKFNGVEIFGKTVGVIGLGRIGQLFAQRLAAFETKVIAYDPYTSPARAAQLGIELLSLDEVLERADFISIHLPKTPETKGMLNKETLAKTKKGVIIVNAARGGLIDEQALADAITSGHVRAAGIDVFETEPSTDSPLFELPQVVVTPHLGASTAEAQDRAGTDVAKSVQLALAGEFVPGAVNVAGGAVSEIVAPWLDIVRKQGVLLGALADELPVSLEIQVRGELSSEEVAVLELSALRGVFSAHIEDAVTFVNAPSLAEERGLEASVTTHSESPTHRSLVDLRAVFGDGRTLNVAGTLTEPAQVEKIVNINGRNYDMRAEGLNLAILNYDDRPGALGKIGTKLGEASIDIQAAQLSQDIDKEGATVILRVNESVPADVQSAIAEAVGAAKVAHVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF03</accession>
    <name>A0A231HF03_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779924.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47388">
        <property type="protein sequence ID" value="OXR47388"/>
        <property type="gene ID" value="B7C42_00511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011288743" evidence="1">
        <location>
            <begin position="30"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="32064" checksum="54E9A83E059177E6" modified="2017-10-25" version="1">MSTDPTPTGRQGRRRLFLAVVTLLVSACAAHGAAVSTGPGLARPATELVRPAPVPRSTPILPSGLVAGFANLRAQLPGRMGLAVMAVGSDHVITLGDWTTGVAWSTIKVPLALAALRRDPVGLADAAQAAITTSDNDAAQALWIALGGGEPAAEAVEAVLREAGDTTTDVADRHNPDARQSIDDPMVFGATPWSLVDQLRFAARLPCLHNASRVVDLMQQITDSQSWGLGSFVGAEYKGGWGPDDDTGAYLVRQFGLVPTWSGQIAVALAAQPDSGSYDDAVEMMDRMSALLSEHVHELRGGECER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF18</accession>
    <name>A0A231HF18_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rnc</name>
        <name evidence="10" type="ORF">B7C42_00604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779861.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47479">
        <property type="protein sequence ID" value="OXR47479"/>
        <property type="gene ID" value="B7C42_00604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="175"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="26255" checksum="423E133645795916" modified="2017-10-25" version="1">MTAGKDEAAAPAAGDAADHASLLEALGVEVRPDLLRLALTHRSYAYENGGLPTNERLEFLGDSVLGLSITERLYLEHPEKSEGELAKLRASVVNMHALAEVARGLGEGGLGRHLLLGKGEELTGGRDKASILADGMESLLGAVHLQHGIEVARGVVLRLFAELLERGPRMGAGLDWKTSLQELTAERGIGVPSYEITSTGPDHDKEFTATAVIGGTAYGQGVGRSKKEAEQKAAGAAWQALTADGSTEAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFB1</accession>
    <name>A0A231HFB1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein B7C42_00654</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47529">
        <property type="protein sequence ID" value="OXR47529"/>
        <property type="gene ID" value="B7C42_00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="118" mass="13256" checksum="061B8FE05BED535A" modified="2017-10-25" version="1">MAHNLALGAHGEELAAQFLQGAGMRIVERNWRCRYGELDLIVRESDTTAFVEVKTRSGLGFGTPAESVTFAKQQRIRRLALLWLAAQSGPWRRVRFDVVSVLLLPGRDPQIEHVRAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFR1</accession>
    <name>A0A231HFR1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetracycline repressor protein class B from transposon Tn10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tetR_3</name>
        <name evidence="5" type="ORF">B7C42_00849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47724">
        <property type="protein sequence ID" value="OXR47724"/>
        <property type="gene ID" value="B7C42_00849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="205" mass="22324" checksum="DB656EFAB171E197" modified="2017-10-25" version="1">MDAALRMLDDTDCEGISMRALAAELGVGTMTLYTYFRSKDELLQAARDQVLDSFHPPAVSGDWADRVRACCQALYRLLVERPAVLRVLAVKPDSDGDFADTATAALELVLSQLRAAGLGRQETARGYVVLLQYTFGSALRHVFAPARRNGENIPSRLQMLDPVAHPTIADLMPELVITHGGGEEQYLYGLDLILDGLRKAAAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGH7</accession>
    <name>A0A231HGH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protocatechuate 4,5-dioxygenase beta chain</fullName>
            <ecNumber evidence="2">1.13.11.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ligB_1</name>
        <name evidence="2" type="ORF">B7C42_00951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.8" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47826">
        <property type="protein sequence ID" value="OXR47826"/>
        <property type="gene ID" value="B7C42_00951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018579">
        <property type="term" value="F:protocatechuate 4,5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="105"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="378" mass="40974" checksum="79A94078D91FFE83" modified="2017-10-25" version="1">MDKNAIERAVLAMARDNELLEQVKAQPSRAPELLGIDREWAEIILAGNRDRLRAIGLNDGLTILVSRWFNDDLGDAASKGGFIVDDTLPRADPDVPDGVVFAGGCSHVPDLLARPEIDPDDAVARLLDGYERLRRDLVAADPDVVLVTADCHFQSFETGHNVIGTGSGHTGSMEFFKRGDLDLNLTGMPDFASELAGAVRAAGLEVEEAERVDLDHGLIVPLRLVLPRPDLPVIPIITQPHRSFSPFNARRFGEALRDVVTRSGLKVAFLATGGLSHWLDPGHFGGVDVEFDTYILKLLETGRGLDLCSLEPYPLLEHGQYEIQNWMIMLGLIGPGVHGTVYTYEPMQASGGGWTVVNMDLARARTETTAAVAAGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSE3</accession>
    <name>A0A231GSE3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000582">
        <property type="protein sequence ID" value="OXR39549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39549">
        <property type="protein sequence ID" value="OXR39549"/>
        <property type="gene ID" value="B7C42_08383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8470" checksum="7709D650A12542F2" modified="2017-10-25" version="1">MMVTGMPTHYTAETGEPLAISTHLHLFSEHVNAGVAAGWQLVESAEAVVDDAWLAAKPKWARLRGHPFTMALVWMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSI4</accession>
    <name>A0A231GSI4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000228">
        <property type="protein sequence ID" value="OXR39589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39589">
        <property type="protein sequence ID" value="OXR39589"/>
        <property type="gene ID" value="B7C42_08343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="80" mass="8379" checksum="54A300B57D2A67A0" modified="2017-10-25" version="1">MATDVAPISGTWAEAPPDTKVRRKFCTFTRCSTVPLKPSRAISASGSGRSPGKSATLAGGGVRLAYQPPPCTETSRTQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTB4</accession>
    <name>A0A231GTB4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000056">
        <property type="protein sequence ID" value="OXR39856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39856">
        <property type="protein sequence ID" value="OXR39856"/>
        <property type="gene ID" value="B7C42_08068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="33602" checksum="414E31DE27EC2967" modified="2017-10-25" version="1">MPRDMFDPDDTLAEFRATRHTIAEAITAYNRDEHRIERGAEAADHHDELEELYRDTSDLMAALDEHLITGGPLPAAWTPTSPAPRMATETGTVTHESRQPDMTAHREHRNHDLHDYDLDPAHLDKVAVSELRDARDQAAYVGDLVCALHADNALEDRDALGPTGRRRTCRTCRDWADHLHDQLTGEIMRAGRWAADVTGEDLVTATTIATQVFALASVAAPSQWQELPEGEYRITVEVNTTAYDVIVPGDEPGWDGQPRPPYIDSFRPGPAGCLILPVIHATTRATAALFEARRYLTAHSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTK2</accession>
    <name>A0A231GTK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000061">
        <property type="protein sequence ID" value="OXR39811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39811">
        <property type="protein sequence ID" value="OXR39811"/>
        <property type="gene ID" value="B7C42_08123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1120" mass="121871" checksum="E34A5E24250F69CC" modified="2017-10-25" version="1">MRCVGDDRQLPAIDAGGAGIDTAHTPDAITLTHVVRFADTAEATAGLALRDGDPSGLGFYLDHQRIHSGSAATVVDKAYAAWFADQHAGRDAIMLAPTHDIVTDLNERARADRLARITESTSATTFLGDGLSASVGDIVCTRRNNRRLPVGDHDWVRNGYRWHIDTVHPDGSLTVTHLRPGGQPGNTTVLPPEYVGLHVRLGYAMTIDSAQGTTADTCHTVLTGSESRNQLYVAITRGIHANHLYVPTTIDGSELSFWTEPAILPRTAVEVLQHILAREATHASARTALRDALDPHRRLGRAADIYLDAIGVATEHTLGNDALTRLDQHAEILLPGLTDAPAYPVLRQHLATLALAGHDPVTALRTAIGDRELDTAKDPAAVLDWRLDTSGAHSTGTGPLPWLHGLPHQITDTTIANQLHARHRIVTDLATQITADARPWTAANAPVWARPLLGNQELIAELAVWRTANHVPDTDLRPTGPARFPTREHDYQTRLNTRVTDALGDLHTATHKWEPLAKRLDTRIINDPWWPVLAAHIDTAAAAGLDIDTLLTAAATQRPLPVDMAAAALWSRLRLDSSALTTHTSQPLRPDWTPHVHDIVGHDDLAEHIINDPAWPRLVAAIDTAPADWAPHDLLSTAHELLLAAADDATTLPLPDQLATALAWRIEILTRPTHEPGNTHTANETATTMTPLTPQPRDAGSAPGDGVGPSPADIVYAIGYLVSAGRIDEARTTFTRLTAHLNTTQRDILQRVITTLSNRAYPTATARLRWAADRYPEHRAFILAAIPATDPHLHQPLDHTQPGHDPRTAARDHREYIDPTRRRPPRPDRGRDAFDTYTHSFADLDADPAHLPVPEGTGTTRHHPSNEPPENADTTSFLAGNGHTVDYDRYAVPDHHELPCLACGLERPLTDTQPRHCDDGLCSTCRDDNQPGIPDHEPADHAAARCTFITDQHPPTAALALLRKDWRHTRNPADRATIEAFANTLLTAETPANENNPPHNHGSDSGFGLANPTQMLTDTELTQAIGTLELRIQLADDEATVYGPAHCTSNTVNPVDTDWLEEELTDLQIELTRRARLTPEQATKEQAQRANREHGTVSWSAAEHPALDTNAVAGTDGPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTQ8</accession>
    <name>A0A231GTQ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase SadH</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sadH_7</name>
        <name evidence="2" type="ORF">B7C42_07916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000046">
        <property type="protein sequence ID" value="OXR39996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778649.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39996">
        <property type="protein sequence ID" value="OXR39996"/>
        <property type="gene ID" value="B7C42_07916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="31005" checksum="B3B31A5C89645E86" modified="2017-10-25" version="1">MTTTARERFSRGTAVVTGAAAGIGRGLAQHLGGLGMTVVVADIDAGRAAEVAAAIVAGGGNAEGYGVDVADEAAVDAMAAAIFDRHRSVELLINNAGVESSGLLWEIDPARWRRVMQINVDGVFYCLKSFVPHMIRVGSPSCIANLSSVGGLNTVAVQSPYIVSKFAVQAMTECLHQDLSIIGAPIQVSAVVPHSIRSEIFLAAQREAPTSDPTANAVFAAMQRDNVEKGLDPLAAAEHMIEQIARGQFWVFSDDEMCTASATRRGEQLLNLRPPANPRDMLARMGVPLPEGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTY7</accession>
    <name>A0A231GTY7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40076">
        <property type="protein sequence ID" value="OXR40076"/>
        <property type="gene ID" value="B7C42_07831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012263132" evidence="2">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="8389" checksum="EB0027C9630F31FF" modified="2017-10-25" version="1">MLTDMGTSHPNRRLGRTAAGILVAVGAVGTTTAAVVAYADNQPAATTGTTLTGNTGSSDTDQSSGTSGSVPQLSPGQGTAHARSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTZ5</accession>
    <name>A0A231GTZ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40072">
        <property type="protein sequence ID" value="OXR40072"/>
        <property type="gene ID" value="B7C42_07876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="33998" checksum="60CE1B41D12457CE" modified="2017-10-25" version="1">MEQWQAKLLARIDQLARTYALVQARGFDGYDGSDTTPEQEWRSHLDALEAERETIEQLAIELGIPAQWVERARTNGVEAAEHSSPTPETAPADTNPSPEAGMPEAASASKQLFIDMAVVDVWHVHRMALLSAARDARLSAGRLGLGADPVADMQFHRNMNLHHQRAAGLSDAAQLSAPEVEALWNSPQVHTARRQAAEQINRWDDLHLEFEWRRYTQPATDPVLPPYIPVDPDTGTPTTHAQARPPDPSELIARAAAALGIDPDRTDRLPIHHATAIDIALPETTARDWDPGPATPPPPTPTRPDLGPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU30</accession>
    <name>A0A231GU30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lptB_3</name>
        <name evidence="11" type="ORF">B7C42_07797</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778629.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40133">
        <property type="protein sequence ID" value="OXR40133"/>
        <property type="gene ID" value="B7C42_07797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="668"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="700"/>
            <end position="707"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR40133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="923" mass="95114" checksum="B537F2443D3A65CA" modified="2017-10-25" version="1">MTDHLSYLVLGLGNGAVYAAIGLALVMTFKSSGVVNFATGTVALYTAYTYALLRKGELLVPIPGLPKSVHLGGPLGVAPAMAISLVFAAVLGVLCYALVFRPMRTASVVAKAVASIGLMIVIQALIAQRVGTGLVSVQPIFALDTFRIGDRTVPTDRIWLAVSIIGIAIVATVVFRFTRFGVATEAAAESEKGAYLTGLSPDRIAFSNWALSSVVAGLGGILIAPLVALNPVAYSMFIVPALAATLVGNFSSIWLTVAAGIVIGALQAEATNLQGLYSWMPKSGTAEAISLLLILGFLVVKGRPLPDRGSVVRKALGRAPRPDHIAIPVVLSLVVAVVALTATSGSYRAAVVSSIIFGVLALSQVVVTGYAGQISLAQLTLAGVSAYALSVLNQHVGIPFPFAPILSALFATVVGVVVGLPALRVRGLPLTVVTLALAVFVEAFWFRNSDLNGGVAGAPIDNPRLFGIDLGIGAGHAYPRIAFGVLCLAVLTVVGLGVAWLRRSSLGTDMLAVRANERSAAAAGIDVSRTKLITFAIGAFIAGLSGALLGYQQTLATPEPFAVFAGIGLFAIMYVAGVTSITGAILAGLMAPGGVVYLLVDRFLHIGDYYAVLSGILLIITVMTNPDGIASRLPRVSWPALRRRDHTPSDEVAVAEPAPPRAAGVPLLSVDGVSVSYGAVAALSDVTFEVFPGEIVGLIGPNGAGKTTLIDAVTGFASASGAVTLDGTAIADAPPHVRARSGLGRSFQDVELYDDLTVAENVRVGAARSQSTVPVAQLVSRTLAVLGLGDMADVAAASLSQGQRQLVSVARVLAAAPAVALLDEPAAGLDNNESRWLGEKLRSVRDSGTAILLVDHDMELVLTICDRVIVLDLGKVIASGPPESIRTNTEVLRAYLGVSSDTVKVDPEAVPELQSGALTTQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUD7</accession>
    <name>A0A231GUD7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000039">
        <property type="protein sequence ID" value="OXR40155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40155">
        <property type="protein sequence ID" value="OXR40155"/>
        <property type="gene ID" value="B7C42_07779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010330">
        <property type="entry name" value="CoiA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06054">
        <property type="entry name" value="CoiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="44209" checksum="551539D1B68727FB" modified="2017-10-25" version="1">MSSSDLLTVALDLTRGCYAPAPQSAASPQMHALRCKGYSGDRTLVCALCYAEHNQLVPLIVRGRPNGQRRPHFAHPAGLTPGGGQHTPESVWHLTSKTLLAEWARTQPGVVEVRNEVALPGNERRSDVRVFFADGSQVALEVQSYSLTDEQWQGRHDAYRRNGIVDVWIWHPDTPTHWIVLREPNIDQQLWTIDPARELVNLMLAEPHSPPAGGDTPQDDTDYAIRHLPPCIGDRLTAATHPLTQLTLTQSGIPIPESLRQQLTDERRRHDRIEQIKRRPRELVTPRTSAGAPPPSPQTATPPTKTPQPPRSGTIAQLKWIELQNTFMAAGHHPDYRDAPSLRRPRPRPTIHCTTCGYLLSPTVNADTITPCTRSHHAQPSPQDHDAMSTPDQIPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUR8</accession>
    <name>A0A231GUR8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909907.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40332">
        <property type="protein sequence ID" value="OXR40332"/>
        <property type="gene ID" value="B7C42_07593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="17926" checksum="FD85643FE584B718" modified="2017-10-25" version="1">MTTFTPVLSASAPYPRAADPIPCAAEHPLPPDALVGRGPQAVVVGLIRPDLHSCRTQAIASAITPAEDHAIRTTAARHRWRVADIAHFPPEGDDTTTDPVDYLLHRVRKWRADAVMVPARTYLTDRWGRDCLEIVRTVCAVVTLSPTRLWPRTAEGAPLSAGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV35</accession>
    <name>A0A231GV35_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40484">
        <property type="protein sequence ID" value="OXR40484"/>
        <property type="gene ID" value="B7C42_07422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="9732" checksum="257DA95A494AF7BB" modified="2017-10-25" version="1">MDSIEGPVPYATGTAADPLTGFPEATRTDRRRCPGLVESGAPYPIVTQGDSPRDRGRAQCASTGSPSAGAGAVLGISTAAAIAPTTKIAVAHQKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV63</accession>
    <name>A0A231GV63_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40527">
        <property type="protein sequence ID" value="OXR40527"/>
        <property type="gene ID" value="B7C42_07466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="384" mass="40572" checksum="8F3C4DBF3B80A29C" modified="2017-10-25" version="1">MIDFYTPPVPTPSCLPGDLVRMRPTFVPQLPHAAAAWQILYASTNSRDELITASGTVILPDTNHTDSDTAPDSRPGRGALLVYHPPFHGLGGRAASQMLAVGDESDSTEISAALEQGWVVAVPDGAGLGVTGTGPHTFLSRAGGQIVLDMARAAQCVPELDADDGVVASMPVVVWGYADGGRAVAAAGELHQRYAPEIDLRGICAGAVASDLAAIAPAISRGPCAPLGLAALIGLSRAYSHLRLRHVLNEEGQRAAAEAETLDGVELFERYPQSLSHFCVREDPWNDLMWRFVLASECLAHNAPSAPLHLYHGHTDRVIPVRAGLRTLIAYRQRQAEVTWREYDSGHGGTALEAIGDVLTVLAHNLTRVTAPGPVIGAPAPTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVA9</accession>
    <name>A0A231GVA9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40485">
        <property type="protein sequence ID" value="OXR40485"/>
        <property type="gene ID" value="B7C42_07423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14838" checksum="6E79DDE7B26102D4" modified="2017-10-25" version="1">MSEAPDESAMQIVTEADAWQPDPRWRSAARLTVLLGEDDHYKHRPRYHEIVRRARDSGLAGASVWRGMEGYGVSSRIHTTRMLDLAENLPVMVMIIDDSQLLRDFVVANAELFESGTVTLSAVQVWQSGGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVD5</accession>
    <name>A0A231GVD5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_07275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909770.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40590">
        <property type="protein sequence ID" value="OXR40590"/>
        <property type="gene ID" value="B7C42_07275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="24857" checksum="FAF86BAE125771EF" modified="2017-10-25" version="1">MRCVSSTPALSDDEAGQRVDPRRARSRERLLDAATRLLATGGIHAVTVDAVTKASKVAATTLYRNFGNSAGLLAAAFERLLPQVEPPTGTGSLREQLTDLLTRQATLIDHTPIHLTALVWLGLGPTEPTDPVAPIDPIDAGDPGRGDGELHSLRAQVIDRYRQPFDQLLTSPAARAELGELDPTYAITQLVGPLVFTRLTGIHPITPAYCHHLINDFLTAHTPPRPSHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVE4</accession>
    <name>A0A231GVE4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_25</name>
        <name evidence="2" type="ORF">B7C42_07292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064902008.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40607">
        <property type="protein sequence ID" value="OXR40607"/>
        <property type="gene ID" value="B7C42_07292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="29685" checksum="806B96A9329C8464" modified="2017-10-25" version="1">MRRESVVVPLRNELSVSVRIVRHNFSDTVVSGLRTFGRTMRVASASAAGTASDVVRLKFQWREAIQQAWYLITVTALPAVLMAIPFGVIVSVQVGNLIHQIGADSLLGAAGGLGVIKQGAPMATGLLLGAAGAAAIAADLGARNIREEIDAMRTMGISPMHRLVIPRMVAMVFVAPMLNILIIFVGVVAGYAVAIGPQGVTPGSYWGTFGSFTTVADIGVSVVKSVLFGFIVVVVACQRGLEAKGGPRGVADGVNSAVVLSVVSIAIVNLLITQLVAMFLPTRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVK2</accession>
    <name>A0A231GVK2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH_38 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782248.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40660">
        <property type="protein sequence ID" value="OXR40660"/>
        <property type="gene ID" value="B7C42_07217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_38" evidence="3">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="36186" checksum="EC2F6973653C0728" modified="2017-10-25" version="1">MSPDTEHNMSQPSTPATYPVAHNPATSQPPDKDAGIGPVAGVAREGAATTGAADRDNGVALSRRRRVSRRTHDTDATSRGGRTVAWAGFVFGSVFSVVMNWLHTWLPADEKPAGWHPGVAPQIGSAVWPVCLLLAVEALSRVRWQTGFGWMLARYGGVGAVAAGSALISYGHVHDVLDKWGYGQLGAGVGPIVLDGLMVTCGFALLSETSHNHSATTEPAPLAPRRGNTSEPVTQPSISENAVPHVGDVSCNSRIAECDTKELPRHAPQQDATARDIDSETDRDARIMFLHHSGATTREIADEIGVHHSTVARVVKRNATSDTERDLHLIAATANEETTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVP3</accession>
    <name>A0A231GVP3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064901987.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40635">
        <property type="protein sequence ID" value="OXR40635"/>
        <property type="gene ID" value="B7C42_07320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040611">
        <property type="entry name" value="TetR_C_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18556">
        <property type="entry name" value="TetR_C_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="211" mass="23611" checksum="C1EFFBA96FF1BBC0" modified="2017-10-25" version="1">MNYASLLVKAVALIRTPAPTGTPERILDAALRQFEVVGISRTTVEDITRRARLARVTLYRHFSSKDQIVEAVILRELGRFLGELEREVSGQATLEDKIVEGFVFTLAAVRGHALLNRLLETEPESLLPFLTVDAGGLIEIASSFLTDQLARELVDVRPNRELHAVSELTVRVILSFILTPSAHIPLDTADDARRFARRHLLPRLRDDTTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVP4</accession>
    <name>A0A231GVP4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppnK</name>
        <name evidence="5" type="synonym">nadK</name>
        <name evidence="7" type="ORF">B7C42_07265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777714.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40707">
        <property type="protein sequence ID" value="OXR40707"/>
        <property type="gene ID" value="B7C42_07265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="196"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="37075" checksum="EB7BEB5CA12DE51B" modified="2017-10-25" version="1">MKREILLVAHPGRSELLETAHRVAKIFADAGIGLRVLEDEAYSTKLDFDDTGEPDGYPVRVMAHGPDAAVGCEMVLALGGDGTFLRGAEMAHPARVPVLGINLGRIGFLTEAEAEHLDDALAQVVRGDYRIEQRMTVDVSVRVDDVVVERGWALNEASIENAARMGVLEVVLEVDGRPVSQFGCDGVLIATPTGSTAYAFSAGGPVVWPELEALLVIPSNAHALFARPLVTSPESRIAVETVATGHDAIVFLDGRRTLALPRGGRFEAVRGAEPVRWVRLDSAPFADRMVRKFRLPVTGWRGRRPERPRATEPARTPIEQPGSGDSEHRRTESTRADRDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW20</accession>
    <name>A0A231GW20_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic di-GMP phosphodiesterase Gmr</fullName>
            <ecNumber evidence="3">3.1.4.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gmr_4</name>
        <name evidence="3" type="ORF">B7C42_07107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.52" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40823">
        <property type="protein sequence ID" value="OXR40823"/>
        <property type="gene ID" value="B7C42_07107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="361"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="513" mass="55295" checksum="3EC5D6F7521438A5" modified="2017-10-25" version="1">MTSGTQHHHTTRIRPLRTWPPEKLWRTTLSAAVVLIVVVLAIAESPALSLTAVLGVVVATLTMIGTGVRRHRPPAPAAWYLLALSSVLFAAGTLLRDFTGSGFPPYDDLATLAGYGGVGVAAFLWLWPRRSSCQHDLVLDSGLIALGALLASWTFLISPVLHNTRQWDASALIMPIYPVIDALLLTLVTHSVVTSSRSETSLRLVHVGLLAILVADLGYNLQSAGSVHLDARVLLTPLLVAYAMVGLAALHPTMVTLGGARRVHPHRSRQRASVIAVTLVVASLVPTVGARVGTVDRVVVSTLLATLLVGVLVRSERAIVRSARSERRAQYQAAHDMLTGLLNRSALLRAPARNRELWTGRPICLLFLDLDGFKTINDSYGHAVGDELIANAAARIRRVIHRDDVAARYGGDEFVVLAGANRAEAAVLAEKLLAAFGKPFELSVTEVTIGASIGIACSGPRSTDATIYDLLREADSAMYHAKDYSLGCAFHDDLRHLPQAESRRRVRRHEPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW46</accession>
    <name>A0A231GW46_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D,L-glycerol 3-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.21" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40711">
        <property type="protein sequence ID" value="OXR40711"/>
        <property type="gene ID" value="B7C42_07269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000121">
        <property type="term" value="F:glycerol-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="295" mass="30388" checksum="0911CE5858BF2E29" modified="2017-10-25" version="1">MAASLREGFEALLLDLDGTLYRGAEVISGAPAALDAGGGAQKLMFVTNNASRSAGVVAAHLRELGFGASESDVVTSAQAAAHVLASRLAAGSTVLIVGTDDLAAEIEQVGLQPIRRFNGVAPAAVVQGHSPQTGWPDLAEAAYAVRAGALWVAANADATLPNERGLAPGNGAMVAALRAATDQEPVVAGKPYAPLLEDALVRAETRDALVVGDRLDTDIDGARCVGLPSLLVLTGVSTLDDLRARPADHRPTYISRTLDALNHPVIRQESPDGDAIDHLAGLLDENPGRAIELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW48</accession>
    <name>A0A231GW48_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ESX-3 secretion-associated protein EspG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">espG3</name>
        <name evidence="2" type="ORF">B7C42_07134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40850">
        <property type="protein sequence ID" value="OXR40850"/>
        <property type="gene ID" value="B7C42_07134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="30631" checksum="3B941AB58595261F" modified="2017-10-25" version="1">MVSEDDVSEDPVAIDLNVDAALVLRHLVGIDSYPPVLALLPNIYRIEDRDRVHAVVTDQLIEAGMIVDGRVHPTIEHWLRCLYRPDVELIARIVDTGVDGGPKGMLRLSLVRSDETQVLAVRSDDHVVIQSVPAGDHRLDTLTEALSAALGPAPALDFAPLSAWAEDFDEVPAEPDERRRALVELGAEPRTASLLSRVLSEVARRAEVVVTEHHDGAIPRPEVCMSVLDTLSGRIIVTPSVALDGRIRATYAPGDDTALHAGVAALVDLLPGRSWFETSRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW80</accession>
    <name>A0A231GW80_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40822">
        <property type="protein sequence ID" value="OXR40822"/>
        <property type="gene ID" value="B7C42_07106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="21762" checksum="DCCD4353792FDAEE" modified="2017-10-25" version="1">MNDALGAGASWPGVEITLEAAIADAEIELFHDLYEQAFGPLRAQAVARQVLHRNEFRAEMTDTRIDKIVARTPAGEPIGLTTLTRHLDTVPWISPEYFATRFPQHAERNAIYYAGFTLVTPTARHGVAFHAMISTVVQILAADGGVVGWDICSYNNSQFSFADALRSAIGEQANVEVAIEDSQTYYAARFIDDDADQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW96</accession>
    <name>A0A231GW96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dibenzothiophene desulfurization enzyme C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soxC_4</name>
        <name evidence="2" type="ORF">B7C42_07029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40894">
        <property type="protein sequence ID" value="OXR40894"/>
        <property type="gene ID" value="B7C42_07029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="1">
        <location>
            <begin position="242"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="43756" checksum="33853868BB826470" modified="2017-10-25" version="1">MTSTHTEPVPPALDSIELQAVIDEIAADARRRREAGGGRPDRALALAREHRLGAVRLPRELGGAGYNLREFFALAVRLAQADPDVPHILRIHWGTVEEALRTRETERSRQWLRWIREGKIFAGAQSELSGQPGVYSYDTLLTAEDDHFRLNGRKFYSTGSIYADYLRIGANDEAGQQVSVVVPGDREGVLHVDDWDGIGQRETGSGTTVLDDVLVHADEIGEFRLLPGPGRPRSPLVHLLLHAIAAGILRALTEDTATLLRERTRSYSWGNAELARNDPQLLAVVGSLSSTAFVVEAAVLAAADALDAATSHVWQHGVPDDGLELAASLQTAQVKVAVEKIALSAAAEAFDAGGASWTRASAGLDRHWRNLRTLFSHNPTVYKARVVGDVVVNDAELPSVGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWX3</accession>
    <name>A0A231GWX3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41096">
        <property type="protein sequence ID" value="OXR41096"/>
        <property type="gene ID" value="B7C42_06866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="12021" checksum="544E0F3D5ED842D1" modified="2017-10-25" version="1">MGNWIFCRMSFAARTSVPNTLGHRHSRRFDAGLDPVCVGGLGQNGRMGTLWLETDEGRLVRANLIAECRVEKIVKAESRLPDEFTIKAQMIYLAGNRYGDVDLSPASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXR3</accession>
    <name>A0A231GXR3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tcrY_3</name>
        <name evidence="11" type="ORF">B7C42_06505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41362">
        <property type="protein sequence ID" value="OXR41362"/>
        <property type="gene ID" value="B7C42_06505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="201"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="269"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR41362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="544" mass="56905" checksum="422BB62162307D56" modified="2017-10-25" version="1">MSDDPAHTAPTPPGTADHAGEPNTLGPASDHVSAPAAVEPGTLALPTISLRRRVTLTAAVISGLALIVVALAVHSLFGVVAARSANTVLTDRVQLARQLAQQNTPPAELIARVDNRSVRARLVLADGGVYGSLSPRHAGDGGPRTRTVTLGGGGTVDRARLTLQIDTPLLTALRSRLGLVLIGVTATAIVAITAALWVGLRHALAPLDSMTRLAREIARGGRGRRLSPTRTDTELGRTASAFDEMLDALEGAEARARASEQQMRAFVGDAAHELRTPIAGIKAMAEAVLHQPADIGPEDRERMYLLLVREAQRAGRLVEDLLDMARIDAGLTLYRQTVDLYDLAHAQVERMRILHPDIDFRLTGHTVLTVADPERVAQILVNLLANACQATPPGGAVSLTVKTVGDSDGSLPTEPMPAPATPADRPGPARDPDTNPSEAATPNAAPGTGTGEVRAEIRVTDTGPGVPAAQREHIFGRLVRLDTSRDRRRDGAGMGLAIARGIARAHGGDLRCVEPPPGTSGAVFLLTLPARDAGRGSPEGPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXX9</accession>
    <name>A0A231GXX9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780338.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41438">
        <property type="protein sequence ID" value="OXR41438"/>
        <property type="gene ID" value="B7C42_06581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="14964" checksum="6977B53B0370617C" modified="2017-10-25" version="1">MTRTRLATALVLIGVAFILYIGLGYVLTPHSMAPGFGLPAWPQGESSAFMTLKGVRDISSGVVLLALLLTRQRFALGVAMLATAVTPIGDMLTVLNNHGSVTTALSVHGLTAALVAATGVLLIRERSAATASRNTVAAAPATAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXZ9</accession>
    <name>A0A231GXZ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41458">
        <property type="protein sequence ID" value="OXR41458"/>
        <property type="gene ID" value="B7C42_06349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="31161" checksum="1CAB46D1C51A084C" modified="2017-10-25" version="1">MSPYTRWKSLAAAGLVAVTYGLAQLGGGAPANAMPSCPGLYVLAVPGTWETSDDDPRKGMLAASVDALPGDVGVAYVAYTATAFPWEGEVYGRSKHEAVEKARAAVVAVAQSCATTRIAILGYSQGADAAGDLAAEIGTGHGVVAPDRIALVGLVSDPRRAPTDTLIGPPVAGAGAGGPRPGGFGQLAARTYTFCAAGDLYCAMPDGDFAGRIAGFFVEISNPDPALFDRYSRDAADLLDSALAAGGLGLLAGQLDASAVDERKAQIAEFVNSGVHQSYPFYVVGPGGETALSWLRRQLVDLIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY26</accession>
    <name>A0A231GY26_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782545.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41499">
        <property type="protein sequence ID" value="OXR41499"/>
        <property type="gene ID" value="B7C42_06391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28614" checksum="E0DBF03D970CA6C1" modified="2017-10-25" version="1">MTDMPAMFTVDEDGRYLPRKWAYGRWGADMLSGPAVCAAAARTLEREHGLPGFVPARFTIDLFKAAKGQPLEVHTEVIRAGRRIHIASATVRQGGVEVAEARLVQLRATDAPPGEEWHSEHPFDPPTDAGVDWWYRSDNDWSTSMGDHQNSGRKSLWAVPLGAVEGEERSAFVQAVVAAESTSLVTNWGSQGIGYINADLTVALDRLPVGDRIGLQAQTHLTGNGVSVGTATLFDSRGPIGTGMVTAVGNAAAQIDFSANGIDFSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYC6</accession>
    <name>A0A231GYC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780934.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41531">
        <property type="protein sequence ID" value="OXR41531"/>
        <property type="gene ID" value="B7C42_06423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="16908" checksum="B1317F6545088459" modified="2017-10-25" version="1">MHSDPPGRAGTSSPVSAAGVAALLRTLPGSPMAGVTAHGSTVLEIVAATTHRARMVEEAQLLHPDSPAREAAATGVPIVITDLAGSSRWPGCGAELRLWGVQAVRCQPLSDDDGAVVGVLSVYTPAANVLSEELADALHPVCRCATDLLQIRRRNPPRLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYD3</accession>
    <name>A0A231GYD3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">31-O-demethyl-FK506 methyltransferase FkbM</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fkbM</name>
        <name evidence="2" type="ORF">B7C42_06433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41541">
        <property type="protein sequence ID" value="OXR41541"/>
        <property type="gene ID" value="B7C42_06433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="53"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="28746" checksum="4A68CF5786AE5070" modified="2017-10-25" version="1">MLTTLQHVRLDDGRTVTCTSPAEARMLWGETTAADGFYRRAAEFLSPGQVVLDIGANIGLSAMMFADTCPGTRVIAVEPVPMTFRCLDRNIAAHVPGGISLRTAVGATPGTRPFTWYPRATANSGFFADRAADDEATATYLRNNGLDDSAIAVITQGLHDGVQLEVGVTTVSAILDQHCRGCEIGLLKVDVERAEWDVLLGITVADWRRIHVVVAEVHDRDGRLREVCDLFTRQGMSAQTRQDPRLAGTEMHEVFAVRPRIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYI1</accession>
    <name>A0A231GYI1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multiple antibiotic resistance protein MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">marR_2</name>
        <name evidence="2" type="ORF">B7C42_06315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41674">
        <property type="protein sequence ID" value="OXR41674"/>
        <property type="gene ID" value="B7C42_06315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15900" checksum="ABC331DBD35A8CB1" modified="2017-10-25" version="1">MVTISETQAAEQWELARLIHEVDLLHNARMREWVAPLGLTVAQASALHEMTGPMTMRELAGRMTCEPSNATIIIDKLEAMGLIQRGPHPTDRRAKQLTLTPDGADMRTRLLKRLTEAPLVTGLTQQEQGALERLLRKALDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYI2</accession>
    <name>A0A231GYI2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_06299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41658">
        <property type="protein sequence ID" value="OXR41658"/>
        <property type="gene ID" value="B7C42_06299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="44"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20854" checksum="4604F26A1F39F174" modified="2017-10-25" version="1">MIAVRMPGTRLTVRVDCVSLVQAGLDRLPERWRALLLAHRELMKFAVVGAITWFVDTGVVYALKLTVLPDKPLTARVFGVLIATIVSYILNREWSFNTRGGRQRSHEAALFFAVSALAVGVTVIPQAVSLYVFDIRVPHVSPFTQAVSNFITGQILGVLLAMAFRFWALRRFVFPQDLREAELEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYL8</accession>
    <name>A0A231GYL8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease MutS2</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutS2</name>
        <name evidence="4" type="ORF">B7C42_06331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41690">
        <property type="protein sequence ID" value="OXR41690"/>
        <property type="gene ID" value="B7C42_06331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="3">
        <location>
            <begin position="313"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="487" mass="52363" checksum="60AD1CB45A493D13" modified="2017-10-25" version="1">MRVRLLYPGDTPAPTALGDTAVEDLGLSALFDTIADSDPATADAVRAVIATAPADPAVIAHRHAVLTDCCANPHLVRAVHDIATTATAVRRWTSTAGRRATGTLVLALPPFTEQLELLRRLRTLLERDGDRVTAAGWTDLIATTKQFDDTYLRAVRDELSMLRFDHGVEFEAGLGAGNKITDVVVHRPPPARRTRFGLSRGASVFDAIADGDGTSDPVMQLKDHALAELADVVAAAADELHAFFLRLRDETAFYLGCLILRDHFDRAATPYCLPHPHPPGTPRLRCRGLRDLTLALGPAPATVAGSDLAADGRSLLIVTGANNGGKSTFLRSLGAAQLMMQAGMFVLAEEFAADVRDGVFTHFVGDEDHTLSYGKLADELVRMNAVVDRIGPHGMLLCNEAFAATGERDAGRIAGPLLRALTEAGVKVVFVTHLHDYARTRYAEAHPGDLFLRAERRPDGTRTHRIVAGPPEPGGHGYDLWAATELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYT4</accession>
    <name>A0A231GYT4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780815.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41766">
        <property type="protein sequence ID" value="OXR41766"/>
        <property type="gene ID" value="B7C42_06108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015286">
        <property type="entry name" value="Porin_fam_mycobact-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09203">
        <property type="entry name" value="MspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011264474" evidence="1">
        <location>
            <begin position="37"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="23442" checksum="83F99F88D6D03220" modified="2017-10-25" version="1">MNTNRANGRRWGARIAGIGAVAATALGLFSTGAADAATFVALPGGELSKTLSDGTVVHVRLDGESANIDPSLGAPPVHRNAWVSGNAHVELSGDTTAVGGSIYPGYTVGCQVDMSGGGVDGGPSASMDWTDGENAKPDAGGNVGGNLTLGPGQAKSFYVLDIEEKGDFGQDVHKSRNKFQGDSGSVAWSDETIGLTGCGGSAQARAFVSVEVETDNVISWVTLWGKPFSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZW4</accession>
    <name>A0A231GZW4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase 2 maturation protease</fullName>
            <ecNumber evidence="2">3.4.23.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hybD_1</name>
        <name evidence="2" type="ORF">B7C42_05755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42156">
        <property type="protein sequence ID" value="OXR42156"/>
        <property type="gene ID" value="B7C42_05755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="16644" checksum="F05B04F1C10DA780" modified="2017-10-25" version="1">MTAARAVVIGVGNDYRHDDGLGPAVARRLESLRIPAVTVARCDGEPTSLLDLWADVELAVVVDAVRCDPSTPGRVRRTTVDALRGCARATGTHALGIADALPLARVLGRVPAELVVVVVEAQRLDPGIGLSGPVAAALPDAVAAVLSELARLGLRPTGAGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZX9</accession>
    <name>A0A231GZX9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic sulfite reductase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asrA</name>
        <name evidence="5" type="ORF">B7C42_05749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42150">
        <property type="protein sequence ID" value="OXR42150"/>
        <property type="gene ID" value="B7C42_05749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="40803" checksum="B96F7739256A33AB" modified="2017-10-25" version="1">MTIGDTVTIDRAGLDRLVTVLVEHGYRVIGPQVREGAIVLDEIDSGDRLPGGWGVHTEPGRYRLFRRDDEAVFSHSAGPGSWKQFLHPPHRRIARLDSDLNTEPVQEIPAPTAFLGVRGCDMAAIGVLGQVLGGGAHPDSAFAARRRELFIIGVNCTEPGGVCFCASMHTGPDVSSGYDLALTERIDDAGHRFLVDVGTEAGARIAAELVTEPSSEAEISAARAEVAAAAGRMGRSMPDVDVRDVLRRSHESPHWQDVASRCLTCANCTMVCPTCFCTTTEDVTDLTGTHAERWERWASCFELDFSHLHGGSVRQSGESRYRQWLTHKLSTWYDQFGSSGCVGCGRCIAWCPAGIDLTVEVARLADTVEGGEDDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0R8</accession>
    <name>A0A231H0R8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional activator TipA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tipA</name>
        <name evidence="6" type="ORF">B7C42_05250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42474">
        <property type="protein sequence ID" value="OXR42474"/>
        <property type="gene ID" value="B7C42_05250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="28831" checksum="63B552868499DCFC" modified="2017-10-25" version="1">MSWSIAEVAKMSGVTARTLRHYDDIGLLTPAHVGGNGYRYYDEDSLLRLQQILVLRELGLGLAEIAEAVDSEPDTLAALKRQYTRLLAERDRLGRMAETVARTIAELEGNKEMSVQINRPENLFAGFDHTQYDDEARRRWPEQFEQSRQASADMTAEDVERMQRELTATMIRMAEFMAAGTPVEDAAVQAEIHTQYEGIRRFWTPNRSAYICLGQMYVDDERFKSNYDRIAAGLAEYQRDAMAVYAEQRLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0S6</accession>
    <name>A0A231H0S6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase SadH</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sadH_4</name>
        <name evidence="3" type="ORF">B7C42_05637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42436">
        <property type="protein sequence ID" value="OXR42436"/>
        <property type="gene ID" value="B7C42_05637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011278879" evidence="2">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="31012" checksum="BAC38F1F34ACDA06" modified="2017-10-25" version="1">MRDRLKSVSGKKTLVTGAASGIGRATAIAAAAQGAELVLTDIDAAGLADTVEEIGRTGGKVLESRALDISEYEAVAAFARDVHARHGSLDVVMNVAGISAWGTVENLEHRHWRSLVDVNLMGPIHVIESFVPEMVRAGRGGALVNVSSAAGLLAFPWHAAYSASKYGLRGVSEVLRFDLARHGITVHLVVPGAVNTHLVQTVEIAGVDRDDPRIQRYVKRFQSHAASPDQAARAIFRGIEKNRFLVYTSFDVRFGYWWARKFAWPYEFTMRRANDQFNRFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0U5</accession>
    <name>A0A231H0U5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit L</fullName>
            <ecNumber evidence="9">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nuoL</name>
        <name evidence="9" type="ORF">B7C42_05266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42490">
        <property type="protein sequence ID" value="OXR42490"/>
        <property type="gene ID" value="B7C42_05266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="137"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="634" mass="66542" checksum="385276EAD2D44957" modified="2017-10-25" version="1">MGTGNLLWLLPALPAAGALILLLAGRTSDRWGHWLGCATAVASFAVAVWAFAEMLGRAGADRAVSHTFFSWVPVAGLQAEFSLQLDQLTMCFVLLITGVGSLIHIYSVGYMAHDPARRRFFAYLNLFLAAMLVLVMADNYLVLYLGWEGVGLASYLLIGFWHEKPSAAAAAKKAFVVNRVGDMGLAIALFLMFATFGSVDFGHVFAGVPHASEGTLTALGLLLLLGACGKSAQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIARSNAIFDAAPAARAGVLVVGAVTLLFGAVIGCAKDDIKKALAASTMSQIGYMVLAAGLGPAGYAVAIMHLLTHGFFKAGLFLGAGSVMHAMNDETDMRRYGGLRKYLPITFVTFGLGYLAIIGVPPFAGFFSKDRIIEAAFGYGGANGITLGAAALLGAGITAFYMTRVMLLTFFGDKRWAAGQSGTEPHPHEAPAVMTGPMIVLALGSVFSGGVFVFGSSLQNWLAPVVGTEHAESAVPAWAVTVAALVVVAIGVAVAYRQYARRPVPRTAPQEVTPLTVAARRDLYGDAFNEAAFMRPGTHLTRSLVFLDNRGIDGIVNTTAAVIGGLSARIRRVQTGFVRSYALSMFTGAALVVAALLAVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H115</accession>
    <name>A0A231H115_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42555">
        <property type="protein sequence ID" value="OXR42555"/>
        <property type="gene ID" value="B7C42_05332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="8371" checksum="D81393A245AD6850" modified="2017-10-25" version="1">MNATTDDDWCDWCALEIRGAPLHVDGRVFCTPMCLGAYRNGSELSSVIDMPQRRDPGACSENADRLARLEAEGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1K1</accession>
    <name>A0A231H1K1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug resistance operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mexR</name>
        <name evidence="2" type="ORF">B7C42_05055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42718">
        <property type="protein sequence ID" value="OXR42718"/>
        <property type="gene ID" value="B7C42_05055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="14945" checksum="BD05422D60D09072" modified="2017-10-25" version="1">MWRALQRVYVDLRPELDAALRRGHGMPASWYDMLVELAGTTRLRMSDLGETMVLSRTRVSRLVTELEARGLVTRETNPADGRSAYVAITAAGRQRLHEATPHHHAVVDQHFAGLAADELGALATALHKVLADDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1N4</accession>
    <name>A0A231H1N4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42765">
        <property type="protein sequence ID" value="OXR42765"/>
        <property type="gene ID" value="B7C42_05103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="189" mass="20731" checksum="15DCC717624A1925" modified="2017-10-25" version="1">MVVDARDSRVSPRAESGSLRNHVGPGEHSAGVTEQDVADRLGGQLIRLMRAIGRTKSHIAKYGPDGLERLAYSVLFCLVHDGPQRTGKLADTLHIETSTISRQTRSLVAHGLVERRADPVDGRACVLAPTAEGVRVFEENRRNRNRWLAEVMAEWPADERARLTDLLELLVSGIEESTAEKSTATAESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1N7</accession>
    <name>A0A231H1N7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42764">
        <property type="protein sequence ID" value="OXR42764"/>
        <property type="gene ID" value="B7C42_05102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="22392" checksum="19A9959EB2FBF6B2" modified="2017-10-25" version="1">MSAPIEPARIPAQPTNQTAKPTASATHFPVSSASPIGSATLPPPPAPSPAGVEIVTETTPRSPLRRAALAAFSALWLVGAPAALAATAGADCGPACADTSGSASGSASGSAGSSGSATAGLLLGLPMKTVALTIVPAPQFPSFDNVITHESSWNPFAVNPESGAYGLGQALPPERMASHGVDWMINPVTQIRWTYDYMVERYGSPDGAWAFWQSHHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1S5</accession>
    <name>A0A231H1S5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42804">
        <property type="protein sequence ID" value="OXR42804"/>
        <property type="gene ID" value="B7C42_05142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="27825" checksum="527C5F4B82B2B961" modified="2017-10-25" version="1">MSSDSNRPPGPVPQPFGPPVGSADWFTPPRPPQPPPLRDSRPAASPPRIVRRAPESPEWAIDPDAIQLALGPSTRPPRRPRRRKWWIAAAAAVVVLALAGGGIALAVTVARKEPGTAAAVATATTPAPAGSAETSAPAPAPPTPACPAESHDGIVVGNGAGGVTDGPNSILGFEYSYYTERSGERAQAFVAPDTVNVAAAAGLQQAIDTVIPPGTTYCVHITTREPDLFDVDIEEHRPDGGHTTYLQSVRTVVRDGRTLLYEIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H263</accession>
    <name>A0A231H263_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_04820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42934">
        <property type="protein sequence ID" value="OXR42934"/>
        <property type="gene ID" value="B7C42_04820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="77"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="523" mass="55897" checksum="D35B4C5DC9662C69" modified="2017-10-25" version="1">MTDVYESETGARSATGSAGARGATESAVIAPVAWPVVAPIAAVGGAALLFAASKYGYFGDELYFLAAGRRLSWGYADQGPMLPLLARIMDTLVPGSYPALRIPAILITVAAIVLCAMITREFGGGRAAQALAALAYACSPFLLLQGSMLTTNTVDTGLWVLITWLVVRWVRTRRDVLLLIAGVVTAVDLQVKWLIPFFWIALAGSCAVFGPRELLRRPLLWAGAGLTVLSAVPQMIWQLRHGWPQLAMGAEIASEQAIIGGRLLFVPISLLLAGVLGVPVLLGGLWALLRWKPLRPYRFLGATLIVVDIVFLITGGRVYYPAGMYGVVLAAGAVALVHWMRKRAAVGRRVAGVATLVVAVAAVATIVTSLPWRPAAAIEPPRDDVSAAIAIGTYGQFGWPELTTAVTTAYRGLPAARRDRAVVVTDTYWQASALDHLGRADLPPVYSPSRGFGYFGAPPDSAETALIVGGEEADLRGRCTSLTPVGRVDTRLGFVGNTRDVTIFDCTGPKQPWSRMWPEWMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2V4</accession>
    <name>A0A231H2V4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-hydroxybenzoate hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pobA</name>
        <name evidence="2" type="ORF">B7C42_04607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43185">
        <property type="protein sequence ID" value="OXR43185"/>
        <property type="gene ID" value="B7C42_04607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018659">
        <property type="term" value="F:4-hydroxybenzoate 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="410" mass="43013" checksum="968A388966E01866" modified="2017-10-25" version="1">MRCDAVIVGGGVAGCALAARLAAAGVAVTVLEREPVYRDQVRGEALVPWGFLEAIDLGIADAVTGAAGASVITRMVPYDESLDIARARRGAIDLSAVVPQAPGVIGVGHPELREALATAATKAGATVVRGVARCVVGHGASPSVDYERAGTEHHLDCRIVVGADGKNSATRTAAQIPFTITSPRVMLSGMLVDDHGAWDRAETTIAVSGRNQYIVIPRADGRIRLYVGRRTTDPERITGPDRISRFLDAYRTPALPCGEALATAQPLGPCATFPLTDAWTDTPVVPGVALIGDAAGWSNPIGAQGLGIALRDARLLAEALLDNRTWTPATLRGYSEERSVRMARLRFATALTDMLSAFGLPDRTAKRARMLKLVAERPETNAALGGIHSGPWTPPAAAFSPDILTTLALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H340</accession>
    <name>A0A231H340_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxygen regulatory protein NreC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nreC_2</name>
        <name evidence="5" type="ORF">B7C42_04697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009598.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43275">
        <property type="protein sequence ID" value="OXR43275"/>
        <property type="gene ID" value="B7C42_04697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="23670" checksum="921AC02E566CCAE1" modified="2017-10-25" version="1">MTTPLRVLLAEDDVLLREGVASLLARSGFEVVGQAGDAAQLLAMVRQEPPDVVVVDIRMPPSHTTEGLDAARVIRAEFPDIGILVLSAHSDVEHAMELLASGHGIGYLLKSRITDVEDFIGTLGRIAKGASVVDPMVVTELVSARRRNDPLAMLSAREREVLALMAEGRSNAGIARQLWVTEGTVEKHVRSILTKLDLAEEADDHRRVLAVITFLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H342</accession>
    <name>A0A231H342_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-branched lipid omega-hydroxylase</fullName>
            <ecNumber evidence="3">1.14.15.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.14" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43222">
        <property type="protein sequence ID" value="OXR43222"/>
        <property type="gene ID" value="B7C42_04644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="46355" checksum="500A076EA6768BB5" modified="2017-10-25" version="1">MIGADEAADVLIDFDWWQQTGQAERDARFDALRRENPRAFVPLGGEPARSKGFWALTRHADILEVSRRPEDFASGEGTQIFDQPRALRDYRGSIIDMDNPEHSRVRKIVSRGFTNKSLESIRGLVESTTHEILDAMPVTGECDFVDNFAALLPLRIISTMLGIPQEHEADILAATNTILGASDAEYIPDQSGAGIAGAVTEASERLIGLLQNLSEERIADPRDDVISMLVAAKEGDNLTPQEMAKFFILLVGAGNETTRNALTHGVYALSRHPDQRDAWLADYRASAPTAIEEILRWASPVIHMRRTVTHDGVELGDQVFSRGEKVVLWYTSANRDEAVFEDPYVFDISRNPNPHLAFGAPGPHFCLGAHLARLELNIAFEALYSRFTDLEAVGEPTLLRSNFVNGIKHLTVRYTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H361</accession>
    <name>A0A231H361_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.174</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">paaJ_2</name>
        <name evidence="6" type="ORF">B7C42_04664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43242">
        <property type="protein sequence ID" value="OXR43242"/>
        <property type="gene ID" value="B7C42_04664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="275"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="400" mass="41331" checksum="E66370DF84B7B67F" modified="2017-10-25" version="1">MTDSNKIEAVIVAGVRTPIGTSFKGTLRDTTAMELAETVVKEALRRSTLAPEQVDDIILAESNYGGGDIARHAAVTAGLPQVPGQAVNRHCAGSLTAIGNAAAQIVAGAERVIIAGGTNSQSTAPLQQFRTPGTTDEFTGQWMPPSHPDTAEAPNQDMSITVGWNTAKAVGITREEMDAWALRSHQRAVKAIDSGVFDGEIVPVQALQADGSRIEFAVDEHPRRDTSLEKLSSLKVLHPEIEGFSVTAGTASGINDAAAAVVVTSAEVAKAQGVEVLATVRAWASTAIDPADTGLAVLDVIPKVLERGRIAASDVALWEINEAFASVPVAACKKLGVDDELVNTAGSGCSLGHPVAASGARMVVTLMYELRRRGGGYGVAAMCAGGGQAGAVLIEVPKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H368</accession>
    <name>A0A231H368_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glc operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glcC</name>
        <name evidence="5" type="ORF">B7C42_04716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009571.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43294">
        <property type="protein sequence ID" value="OXR43294"/>
        <property type="gene ID" value="B7C42_04716"/>
    </dbReference>
    <dbReference type="GeneID" id="66723405"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="29316" checksum="ACB69638EB81D05F" modified="2017-10-25" version="1">MADRASAPIFDSRSTAARPIRTPKTAQLVARNLRRMIIDGELKDGDHLPHEAELMEHYSVSRPTLREAVRVLESERLVEVRRGSRSGARVCVPGPEIVARPASLLLELSGATVADVFVAREAIEPDAARILATDGTEEDFDELERIVDEEIPAAFASDNLAAGTSAFHLRIVQLSGNATLAIIAGMLHEITERHTGAVLLETRADKERYEASYKLEIRSCRRLIKLLRARDADGAFAHWQKHMVNARMSLLEGRENVQVRDILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H391</accession>
    <name>A0A231H391_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_20</name>
        <name evidence="9" type="ORF">B7C42_04741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43319">
        <property type="protein sequence ID" value="OXR43319"/>
        <property type="gene ID" value="B7C42_04741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="382" mass="41841" checksum="2DB11FB3D5F0C336" modified="2017-10-25" version="1">MQREIFDSEHDQYRETVREFLARYATPHQEQWEKDGIIDKQLYVEAAKFGLIGFSVPEEFGGGGMSGDFRYNAIVAEEVARASSGGPAFTLQNDVLAPYMLELTNDEQKARWLPRFASGELVAAVAMTEPGAGSDLQGIRTSAHKDGDDWVLTGAKTFISSGIHADLVIVVARTDPAAKASAAFTLLGVERGMAGFTRGRNLEKLGMHSQDTAELNFDQVRVPSANVIGEVGKGFLHLMRNLPMERLSIAVAAVASCRTLLNTTLEYVKSRKAFGTPIGSFQANKFELATLETEVDLAQVYVDRCITALNAGTLDGVDAAKAKWWTTELQQRLIYACQQMHGGYGYMMEYPIAKAYADARIQTIYGGSTQIMKEIIGRSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3A2</accession>
    <name>A0A231H3A2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lptB_2</name>
        <name evidence="11" type="ORF">B7C42_04751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43329">
        <property type="protein sequence ID" value="OXR43329"/>
        <property type="gene ID" value="B7C42_04751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="676"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="708"/>
            <end position="715"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="917" mass="95555" checksum="2D34B1412101C312" modified="2017-10-25" version="1">MTDHLVFLTLGLGNGAVYAALGLALVLTFRSSGVVNFSTGAVALYVAYTYGLLRKGELLNPIPGMAKSIHLGGRLGLWPAMAISLVIAAILGMLIYAVVFRPLRTAPPVAKAVASIGVMLFVQALLALRVGTTPVSVKAILPSGALELGDTRIPADRLWFAGVILVLAVVLTLSFRWTRFGLATRAAAESEKGALVTGLSPERIAFGNWALSTMVAGLSGILIAPIVPLIPVSYTLFIVPALAAALVGNFNTLGLTVVAGLGIGMLQSETTHLQSTVDWFPKSGMAELVPLVLILIFLVFRGRPLPSRGAIIVQTLGRAPRPKSLLVPTILSVVVAVVALLTTSGSYRAAVITTLILAVVALSQVVVTGFAGQISLAQLTLAGVGAFTLSRLTTDLGIPFPIAPILAALVATVIGVVVGLPALRIRGLPVTVVTLALAVFLEAFWFRNSNLNGGLNGAHIENPTLFGVDLGIGAGQAYPRIAFGVVCLVVLVLVAVGVAKLRTSRLGASMLAVRANERSAAASGIDVARTKIKAFAISAFIAGLGGALMGYQQTVATAESFSVLAGIGLFAIVYIAGVTCVSGGILGGIIGAGGILFIVMDRVLHLGDYYSIISGILLVLTVIQYPEGLAGHLHQHSARIRNRINRIRPPRTERQAEPAVPEAATPLRDVSDEVLLSAAGISVRYGGVVALDDVGFDVRSGEIVGLIGPNGAGKTTCIDALSGFASCSGTVSLGDRDIDELEPHKRSRLGLGRTFQGIELYDDLTVRENVAVGTVAAADRSTGSAPPDIDALFEVLHLDTVADRSVSELSQGQRQLVSVARTLAGRPRIVLLDEPAAGLDSTESQWLGARLKAVRDAGVTVLMVDHDMELVLEICDRIVVLDLGRVIAEGTPQEIQSNPDVVRAYLGTTHATTEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M1</accession>
    <name>A0A231H3M1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43450">
        <property type="protein sequence ID" value="OXR43450"/>
        <property type="gene ID" value="B7C42_04317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11479" checksum="294EB9CAAF0946E8" modified="2017-10-25" version="1">MTEFDLTTFTTAIQDRSRSWESKAITWELTLGPTRDKSAAWVICESTHTAAQLTVWTSGEAELDIASLTTDASTSTHHQFADRQDLEACLDHLTKRLNTPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5D9</accession>
    <name>A0A231H5D9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 19">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="19">NN:DBI PRT</shortName>
            <ecNumber evidence="19">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">cobT</name>
        <name evidence="21" type="ORF">B7C42_03616</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="5 19">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 19">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 19">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 19">Belongs to the CobT family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="19"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44060">
        <property type="protein sequence ID" value="OXR44060"/>
        <property type="gene ID" value="B7C42_03616"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="14 19 21" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 19 21" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXR44060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="669" mass="67586" checksum="9D7BFEC16BD30DC9" modified="2017-10-25" version="1">MRADWYRADVVNDAAGGRGLRTLVLGGARSGKSAYAEEVAGRSGPVRYVATAVPDPADADFADRIAAHRVRRPGTWHVVEGDPITVLGDPAPVTLIDDLGTWLTARIDARAAWESPRGTVGPDIDALVAAVTGYADRLLIVSPEVGLGVVPATASGRLFQDEIGTLNQRLAAVCDEVVLVVAGVPVVLKGAEAAGASTGGGIGTASAAAAAAGLAGGAAERVSASDSADTVGREHPFHGSGFADSAAAERALASGHDAGGAAASTGTSDVTDVSAGARTGSGAADEGAGREFAGAAAAAAGSTPRGLAEFDGTTPAFGPVAAPDARIRAEAEQRQLQLTKPAGALGRLETLGNWVAACQGQCPPHQFRRARVVVFAGDHGVARHGVSAYPSEVTAQMVANFLAGGAAVNALARLADATVRVVDIAVDADTDPSVSTHKIRRSSGAIDREDALTEAELYAALAAGRAIADEEIDGGADLLIAGDMGIGNTTPATVLIATLTDTEPVVAIGRGTGVDDAGWMRKASAIRDAMWRARPHRQDPFALLRIAGGADFAATAGYLAQAAARRTPVILDGVVVTAAALIAEMLAPGAKRWWVAGHRSTEPAHPLALAKLELEPLVELDMRLGEGSGAVSALPLLRAAIAALSEMSTFGEAGVSTAESDSPAPEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5H4</accession>
    <name>A0A231H5H4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator CdhR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdhR_9</name>
        <name evidence="3" type="ORF">B7C42_04205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43966">
        <property type="protein sequence ID" value="OXR43966"/>
        <property type="gene ID" value="B7C42_04205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="220"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="36722" checksum="F434E787D90A9B88" modified="2017-10-25" version="1">MPAPRTVVFVVYEGMQLVELAGPMDVFGAVNTMGGETAYRLVSASPHGRSIEAHGGLTIGVGTSLHDLASSAAEIDTLMVVGGMVSGPVSAQVVRELPALARRSRRITSVCSGALLLAAAGLLDGYRATTHWGSADLLARSYPRVVVEPDRIYVHDRNRWTSAGVSAGIDLALALVEDDHGREMAQQVARAFVVFTRRSGGQTQFSAQLRTQPARTPAIRAVQHWLPDHLGDDLAVSTLARRAGMSERHFARAFRAETGSTPAAFVAELRLEAARRLLESSELTVTAIARVVGYRHGETLHRAFVRRLATTPEAYRRQCAEAGLGAVAAEPAVSADRESASSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5V2</accession>
    <name>A0A231H5V2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator RutR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rutR</name>
        <name evidence="5" type="ORF">B7C42_03835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44274">
        <property type="protein sequence ID" value="OXR44274"/>
        <property type="gene ID" value="B7C42_03835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20613" checksum="5CD3B7472138FCD8" modified="2017-10-25" version="1">MAESTRTRLTAAERSEQVLAAAVTAFAETGYAATKTDEIARLAGVSQPYVIRLFGTKERLFVAAVNQACERIEEVFRAARSDAPANATAQEALQALGKGYETFLAERELPLLLLHGFSASADPAIGDNVRERFGRIYDLVRELAGADADDARRFMATGMLITVMTAMQVIGPDAVPTRWAEEINACLQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Z2</accession>
    <name>A0A231H5Z2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">bioB</name>
        <name evidence="16" type="ORF">B7C42_03742</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44182">
        <property type="protein sequence ID" value="OXR44182"/>
        <property type="gene ID" value="B7C42_03742"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="74"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR44182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="353" mass="38407" checksum="996CFAD290C4F0E3" modified="2017-10-25" version="1">MPRQARPHRPEEGIRAVTQAPVKTDILATAREQVLERGVGLTQEQTLEVLRLGDDQLEALLELAHEVRMKWCGPEVEVEGIISLKTGGCPEDCHFCSQSGLFQSPVRAAWLDIPSLVEAAKQTAKTGATEFCIVAAVRGPDERLMAQVAAGVEAIRNEVDIQVACSLGMLNQEQVDQLAAMGVHRYNHNLETSRSHFPNVVTTHTWEERWDTLRMVREAGMEVCCGGILGMGETLEQRAEFAANLAELEPDEVPLNFLNPRPGTPFGDLEVLPAADALRAVAAFRLALPRTILRFAGGREITLGDLGAKQGILGGINAVIVGNYLTTLGRPAEADLDLLTDLKMPIKALNETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6F9</accession>
    <name>A0A231H6F9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tRNA/rRNA methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775741.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44438">
        <property type="protein sequence ID" value="OXR44438"/>
        <property type="gene ID" value="B7C42_03227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="3">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="322" mass="33404" checksum="B51ED13A12764D30" modified="2017-10-25" version="1">MAGNSQRRGAIRKGGTKKGAVVGSGGKRRRGLEGRGATPPATMRKNHPAAKRAAVAAKAAKATQGQNRARPGTRKGDDGPELVLGRNPVVECLRAEVPATALYVALGTENDDRLTESVQRAADAGISILEVSRTDLDRMSANGLHQGMALQVPPYRYAHPEDLLDSARASGTAPLLVALDNISDPRNLGAVIRSVAAFGGHGVVIPQRRSASVTAVAWRTSAGAAARLPVARATNLTRTLKDWAKAGLQVVGLDAGGDTVLDDFDGTTPTVVVVGSEGKGLSRLVRETCDTIISIPMAGPVESLNASVAAGVVLSDIARQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6L9</accession>
    <name>A0A231H6L9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44673">
        <property type="protein sequence ID" value="OXR44673"/>
        <property type="gene ID" value="B7C42_03467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="42"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="25281" checksum="8680D379E1451329" modified="2017-10-25" version="1">MTAALPAQPDPVAVAARYAGRQPTGWGMDLPGIITSIPAQGKQMALTFDACGGPDNDEINTELMNYLVAHDIPATLFLNKRWIDADPGRAEQLAANPLFELANHGTRHCPLSVTGHTAYGIAGTVSPQQAIDEVWGNHERLTRLLGHPPRFFRAGTAHYDDVAVAIVRDLGETPVGFSINGDAGATFSAAQVRTAMSAAQPGAISIAHMHRPKSGTAEGMSVVLPVLRSRGFEFVKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6N2</accession>
    <name>A0A231H6N2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.174</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">paaJ_1</name>
        <name evidence="6" type="ORF">B7C42_03288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44499">
        <property type="protein sequence ID" value="OXR44499"/>
        <property type="gene ID" value="B7C42_03288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="271"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="41635" checksum="8F0BA6A8EAE4C61F" modified="2017-10-25" version="1">MSTSSDRRRYAPVREAYVIDAVRTPIGKRGGALAGVHPADLGAAALQGLLGRNAIDPGNVDDVIFGCVDAIGPQAGNIARTAWLAAGYPEEVPGVTVDRQCGSSQQAINFGAQAIMSGTAEVIVAGGVQNMSAIPISAAMLAGKEYGFDSPFVGAKGWDHRYGTGEVSQFNGAQLIAEKWDISREDMERWALRSHERARKAIAEGAFDREIVPVGDFWIDEGPRETSLEKMAGLKPLSEGSRLTAAVASQISDGASATLLASDWAVAEYGLKPRARIHHVSARGADPIYMLTAPIPATKWALEQTGLTIDDIDVVEINEAFASVVLAWLKETGANPDKVNVHGGAIALGHPLGATGAKLFATLLNELERVNGRYGLLTICEGGGTANVTIIERIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6P3</accession>
    <name>A0A231H6P3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent hydroxymycolic acid dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd2_4</name>
        <name evidence="2" type="ORF">B7C42_03216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44427">
        <property type="protein sequence ID" value="OXR44427"/>
        <property type="gene ID" value="B7C42_03216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="32547" checksum="40338D00D3582145" modified="2017-10-25" version="1">MDIGLHLTNFALDTPSERIGSRLAEVVRTAEGSGFSLIAVGDHLWQSPWLGRVEQNVLEAYSTLSFIAAHTSRVQLTAVVSGVHYRHPAMLGKLVTTLDVLSGGRAWLGIGTGTSTGDVEGYGLPFPPLRDRYEMLEEALRICRAMWTGERGGSEPLSGKHFHVERPLNAPQAVRTTLWGGHRPHPPVLIGGDGARRTLPLVARYADVASLRPGPELASKIELLDRLCVEIGRDPREVRKSCVFAFDLGPGGGGVGQVLGQLKRMADMGIDLVIGRVAGVDDLTPLEVMGREVIPVAAEFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6R7</accession>
    <name>A0A231H6R7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent stearoyl-CoA 9-desaturase</fullName>
            <ecNumber evidence="2">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">desA3_2</name>
        <name evidence="2" type="ORF">B7C42_03507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44713">
        <property type="protein sequence ID" value="OXR44713"/>
        <property type="gene ID" value="B7C42_03507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="45952" checksum="43536ACD74FC0D9C" modified="2017-10-25" version="1">MAITEIGAYAHLGPADIEALGRELDRIRADVEADLGAHDANYIRRTIVFQRTLDAAARLIILGGRGRLAWLLGTAGLATAKSVENMEIGHNVSHGQWDWMNDPEIHSTTWEWDMAGLSAQWRYAHNVRHHLYTNVLGMDDDIGFGVMRVTRDQRWHPRLLLQPLQNVLLAATFEWGIAWHDLDSAHDRAADPAEKAGQTRALLGKLMRQAGKDYVLFPALSGKRWRRTLFANLGANLLRNLWAYLVIFCGHFPDGAEKFTPSVLESETKAEWYLRQMLGTANFDAGRVQAFMSGNLCYQIEHHLFPDLPSNRYREIATRVRALCEEFDLPYTTGPLLRQYALTLRTIHKLALPDRFLTATSDDAPETASERKFLGYRPFAAADGAPSRSRRGLRTALRAVAAKTALPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H706</accession>
    <name>A0A231H706_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776253.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44704">
        <property type="protein sequence ID" value="OXR44704"/>
        <property type="gene ID" value="B7C42_03498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="20991" checksum="C53F68EEFAF6073B" modified="2017-10-25" version="1">MSDWLAHPRSLQAAERILDAAASLFSERGVNATQMGDIAKAAGCSRATLYRYFDNRQAVQLAYVHREARRVGARVTAEIGAIADPGERAVAGVLASLRAVRSDPLLIAWFRPDDAGATLQIAQTSEVIEAIARSLFATETAPAPDEAHEDWTRLARWLTRIIVSLLTVPGRDEAEERDMLERFIAPLLARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7M5</accession>
    <name>A0A231H7M5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44757">
        <property type="protein sequence ID" value="OXR44757"/>
        <property type="gene ID" value="B7C42_02711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="28137" checksum="BA49E4235C2C4284" modified="2017-10-25" version="1">MSRSTTILRGMAAGKGGTPSKEAKAAAKAARRQASKERRQQLWQTFQMVRKEDKLLLPLMIGALVGITVVLFLIGFLFDMQWFLLPVGILLGALVAFIIFGRRVQKNVYAKAEGQAGAAWWVLDNLQGKWRATQAVAATTQLDAVHRVIGLPGVILVAEGSPQRVKSLLAQEKKKTARLVGDTPIYDIVIGNEEGQVPLKSLQRHLTKLPRNIDAKRMDLIEGRLTALATRGGPALPKGPLPAGAKMRGVQRTIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H843</accession>
    <name>A0A231H843_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45183">
        <property type="protein sequence ID" value="OXR45183"/>
        <property type="gene ID" value="B7C42_03141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="14961" checksum="6C0AC3693219C2D2" modified="2017-10-25" version="1">MNAHTRTAASQAALAVALHEVFDASTHTPDSFELWGAIAEEALRHLCAPAPTSLPQSLAVFTVYRKLRTDACFYPGTGRIEVTTGPLAGTSYPDFDHAARAVASDHAAAGAVSCPAVDLPTWRLNSAAHLPGPFAHALRAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8U6</accession>
    <name>A0A231H8U6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase RhlE</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhlE_2</name>
        <name evidence="4" type="ORF">B7C42_02404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45279">
        <property type="protein sequence ID" value="OXR45279"/>
        <property type="gene ID" value="B7C42_02404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="27"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="258"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1595" mass="171289" checksum="5C59A7B4BB2BB046" modified="2017-10-25" version="1">MQQFSRPTQEWFDGAFPAPTTAQLGAWEAISAGEHTLVIAPTGSGKTLSAFLWAIDRLATREPTDGPQRTAVLYISPLKALAVDVERNLRAPLVGITRTAARLGMPAPEISVGVRSGDTTPADRRTLQRRPPDILITTPESLYLMLTSAARETLSQVGTVIVDEVHAIAGSKRGAHLALSLARLDQLTERPAQRIGLSATVRPPQEVGRFLVGSAPITIVSPPAPKTFDLSVRVPVADMTEPGESDQPGSIWPHVDAAIVDLVLAHRSSIVFANSRRLAERLTARLNEEYAERIAEPDEAEEVAGRREHAPPAQLGSPTEVNHGAAPLLARAHHGSVSKEQRAIIEDDLKSGRLRCVVATSSLELGIDMGAVDLVVQVEAPPSVAGGLQRVGRAGHQVGEISRGVIFPRHRTDVIHCAVASMRMTAGQIEELKIPAHPLDILAQQTVAACALEPIDVDEWFETVRGTGSFAALPRSAYESVLDLLSGRYPSDEFAELRPRLVWDRDAGTLTGRPGAQRLAVTSGGAIPDRGLFPVFMVGEKASRVGELDEEMVYESRVGDVFALGATSWRIEDITHDRVLVSPAFGLPGRLPFWHGDSLGRPAELGAALGEFVRTAGQAVERAPAGRIAELVRDAGGSAAAFDGETLDSGGPTTRGNGATRRTPSRPRAGAAAGNRGGELVELEQLVHAAGLDDFATANLVSLLAEQRQATGHLPTDRTLLVERFRDELGDWRLILHSPYGLPVHAPWALAVGARLRERFGVDAAPTASDDGIVVRLPDTTDDPPGAELFVFEPDEIDDVVTEQVGGSALFASRFRECAARALLLPRRDPGRRAPLWQQRQRAAQLLDVARKFPDFPILLETVRECLRDVYDLPALRDLLTDVARRKLRLVEVETASPSPFANALLFDYIGQFMYEGDSPLAERRAAALSLDSSLLAELLGRVELRELLDAAVLELTERELQRLTPERHARDAEGLADLLRLLGPLTPAEAAARCTADPGPWFAELLRARRVLEVSFAGSRWWTAIEDAARLRDALGVPLPIGTPAAFIEPVADPLGDLVARYARTHAPFTLDAVARRFGIGPAVAATALHRLGAEKRVVEGEFTPGSAGAEWCDAQVLRRLRRRSLAAARKEVEPVSTGAFGRFLPAWQHIGTSTLRGVDGVAAVVEQLAGVPIPASAWESLILPSRVRDYTPAMLDELTASGEVLWSGHGAITAKDGWIALHPADQAPVTLGPPQEIDFTDVQLRLLTALGAEMTAAATDAIPLDADGTVATEAGASDGNRLVVVAGGAYFFRQLSDATGVLDDAAVAAALWELVWAGYLSGDTFAPVRARLSGTTRSTTAHRTPRRTPRGRMYLPRPAMPTRTGPPAVAGRWSLLPQRLPDNTIRAHATADLLLERYGVLTRGSVQNEDIPGGFALMYRVLTEFEDRGRCRRGYFVDTLGGAQFSTTDVVDRLRSYDSDRPGAGTGRVGTVALAACDPANPYGAALPWPKNAGEGAGHRPGRKAGALVVLAAGELALYLERGGKTLLTFTEDPEIRTEAAAALAALVHDRRIDSLVVERVDGESVHGNTFATFLTDAGFHTTPRGFRLRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8X6</accession>
    <name>A0A231H8X6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">sdhA_3</name>
        <name evidence="19" type="ORF">B7C42_02433</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45308">
        <property type="protein sequence ID" value="OXR45308"/>
        <property type="gene ID" value="B7C42_02433"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="17">
        <location>
            <begin position="13"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="18">
        <location>
            <begin position="460"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXR45308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="594" mass="65722" checksum="2A938C18DA1CAD4A" modified="2017-10-25" version="1">MSETRPVQEHRYDVVIVGAGGAGMRAAIEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDYLVDQDAAEIMAKEAIDAVLDLEKMGLPFNRTPEGKIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFYNEFYVLDLVMSETDRGSVATGVVAYELATGEIHVFHAKAIIFATGGSGRMYKTTSNAHTLTGDGMAIVFRKGLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGILRNASGERFMERYAPTIKDLAPRDIVARSMVKEVLEGRGGGPNKDYVFIDVTHLGEDVLEEKLPDITEFSRTYLGVDPVKEPVPVMPTCHYVMGGIPTRIRGEVLRNNTDVVPGLYAAGECACVSVHGSNRLGTNSLLDINVFGRRSGIAAAEYAARTEFVELPENPAQMVQDWLALLLSDHGNERVADIRTDLQVTMDANAAVFRTEETLKTALTDIHSLKERYQHITVQDKGKRYNSDLLEAVELGFLLELAEVTVVGALNRKESRGGHAREDYPDRDDVNFMRHTMAYKQVEPGKPAELIADIQLDFKPVVQTRYEPMERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H923</accession>
    <name>A0A231H923_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45302">
        <property type="protein sequence ID" value="OXR45302"/>
        <property type="gene ID" value="B7C42_02427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17023" checksum="7F20D52FDBF0958D" modified="2017-10-25" version="1">MTARTTVRPATLGRGAMILVFVLMLVGGALRSVEAGCQNSLKLALHNVFLCGVISYAVALAGVGAIFAVSPRQPWPSRADLKTMPRWAPFGGLTGGAAIFAMITVASSVGVSTFNALIIAGQMLLAVVMDHFGVMGFPRRPLSAQRLAGCVLIVVGAYLMAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Q3</accession>
    <name>A0A231H9Q3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45427">
        <property type="protein sequence ID" value="OXR45427"/>
        <property type="gene ID" value="B7C42_02552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013212007" evidence="2">
        <location>
            <begin position="32"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="43897" checksum="C05037C07CD50B46" modified="2017-10-25" version="1">MRNSVRVLAAAVAALALAATGCGSDPTPAPAAEPTVDLSGLDVGPYDATPRDMGKPTNPGQAAFYEAERLGSTMPLPMDIDPAFTHTGKLDTLVFLDPKTSVMKDFTDLSNFAEDAPDLIGGFVSYGRDDPDNLGSELVNAAMIFPTEQRATEVAAALERRDFGRDPQTQAVAIPNYPLTHAHWVPTKQAINSWYPAGRLVVFTSVYDQAKNWFGKVDLPALVSRVQKSLDTVAPALAKFQPTPPDKLMDHPIDVDGMLGRTMIRPKEATGEWLNPPGVYLGRAGLHFSSDPGESRVWYDRDGVDRFADYGNELYRARDAAAAADIRDELGGAEKHFKQAASPRNLPVAKCREYNGKEQLAVRFYCSVYYGRYASLAWGEQLLDAQQRISAQYTILVKADPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Y2</accession>
    <name>A0A231H9Y2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45659">
        <property type="protein sequence ID" value="OXR45659"/>
        <property type="gene ID" value="B7C42_01951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="177" mass="20017" checksum="5E46F9B021E5F200" modified="2017-10-25" version="1">MRRLDGEVHVHYSQLYVESDPESVGPDMEEAFAGQSAGLCGAAVPGALWLMTGLHTGNVGFTAEVRGQAPPLDTAWEDVVEVSFRPVSAQSWLMQWAGEACWELDLEEIDYRVRYCAQGMDQAHQKDTRLDDEPLLDRYLLQFWPAPPEPDRVVRQTAEIAAYWHDYARRQPSPTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA72</accession>
    <name>A0A231HA72_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fadJ_1</name>
        <name evidence="10" type="ORF">B7C42_01919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784014.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45627">
        <property type="protein sequence ID" value="OXR45627"/>
        <property type="gene ID" value="B7C42_01919"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="320"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="501"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="719" mass="76975" checksum="C0C55A0EFFE02A39" modified="2017-10-25" version="1">MTKTIRWEQDSDGIVVLILDDPSQATNTMNADFQESFAQTVERLEAEKDSITGVVITSAKKAFFAGGDLRDLIRATPEHAEHVTEAATAMNAQLRRLETLGKPVVAAINGAALGGGFEIALATHHRIAADVRGTVVGLPEVTFGLMPGAGGVVRTTRLLGIRSATRNVLLQGQRHGPARAAELGLVDEVVSAVDELLPRAKAWIKADAGAGQPWDAEGYRIPGGSPTDPAFAAHLSSLPANLRKQVKGAPLPAPRAILAAAIEGAQVDFETASRIETRYFVNVVTGQVAKNMTKAFFFDLKRITAGGSRPDGFEKYVPWKVGVLGAGMMGAAIAYVTAKAGIDVVLKDVSPENAEKGKGYAVALERKALSRGQTTQEASDALLARITPTSDPADLAGVDLVIEAVFESPELKQKVFGEIEEVVAPDAVLGSNTSTLPITDLAQGVRRQDDFIGIHFFSPVDKMPLVEIIRGEKTSDATLAKVFDYVLRIGKTPIVVNDSRGFFTSRVIGTFIYEAVAAVGEGVEPASIEQAAAQAGYPAPPLQLMDELTLTLPRKIRLETRAAVEAAGGHWTPHGSEAVLDRMIDEFDRKGRSTGAGFYDYVDGRRTGIWPGLREAFNSGSTRIPLADLRDRMLFAEALETVRCFDEGVLNSVEDANIGSLFGIGFPAWTGGVVQYINQYEGGLAGFVARARELAERYGEHFLPPRSLVEKAGKGEIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAA1</accession>
    <name>A0A231HAA1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45666">
        <property type="protein sequence ID" value="OXR45666"/>
        <property type="gene ID" value="B7C42_01958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="164" mass="18477" checksum="981B4A3F8CD302CE" modified="2017-10-25" version="1">MTEQNFSTTFAVDRTPETFFDAVLDVRGWWSKTLTGRSEKPGDVFTYEVPGVHRATIEVTEVVPHERVVWRVLDARLTLVDDQTEWNGTEIRFEITPGADTTELRFTHVGLTPAFECFDACRKGWSFYIDTSLRDLIATGTGQPDEDPQALALANAATPHRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAJ3</accession>
    <name>A0A231HAJ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit 1</fullName>
            <ecNumber evidence="7">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nqo1_2</name>
        <name evidence="7" type="ORF">B7C42_02160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45868">
        <property type="protein sequence ID" value="OXR45868"/>
        <property type="gene ID" value="B7C42_02160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="319"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="431" mass="44032" checksum="B201FC3743F68B74" modified="2017-10-25" version="1">MDAIANPIVSATPGATPRIVGGDAGTESAAAYRASGGYAPIEDPARLLAEVVESGLRGRGGAGFPLGAKLLSVQRHCRAGVRPVVVANGEEGEPASGKDRLLLRRRPHLVLDGLRAAATILGADRAVVYVSDDRAADSVTAAVAELGPAELPVPTEIVTVAAGYVAGEETAAVRAIDGGPATPTDKPPRPYAAGVGGRPTLVSNVETLAQLAWIHRFGAAAFRTVGTADSPGTFLATVTGAGREPAIYELPHGYSFRALLEMHGVAANRVHGALLGGYFNGLTNSRVLDARLDHETLRAMGTGLGCGAVALLTPEDCPVAVAASVLEYFDRENAGQCGSCFNGTAAMSAVASALRDGGAEAADLDRLRRWSTVLRGRGACGTLDAATNAGRTLLDEFPDAVARHLVGGCAICAATPFAAVRPFDVEAVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAK3</accession>
    <name>A0A231HAK3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-dependent 6-phosphofructokinase isozyme 2</fullName>
            <ecNumber evidence="6">2.7.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pfkB</name>
        <name evidence="6" type="ORF">B7C42_02058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45766">
        <property type="protein sequence ID" value="OXR45766"/>
        <property type="gene ID" value="B7C42_02058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="8"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="32512" checksum="B5CF0328ACE0AC95" modified="2017-10-25" version="1">MPIVTLTMNPAIDSAARTDLVLPTDKMRCSAPRFDPGGGGINVARTVAALGEPVTAIYPAGGHTGVFLEQLVRAAGVPSYAVATAEPSRENLAVFADDTGAQYRFVFPGPRLTPAEQHRCLAAVERHAPGADYVVASGSLPPGVESDFYQILADVAAAQGVPMILDTSGAALRGIRRGVFLIKPSVRELAQLAGRALPDRDTQVAAARELVNASVAEVVVVSLGAEGVLAVTAERSQWFPAIPVPVRSGIGAGDAMVGGIAVGSARGYELDDAIRLGIAAATAALTTSGTAPGLRSRIEQLYEEQTRAAAPVAEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB53</accession>
    <name>A0A231HB53_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative propionyl-CoA carboxylase beta chain 5</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">accD5_1</name>
        <name evidence="4" type="ORF">B7C42_01039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063012965.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46075">
        <property type="protein sequence ID" value="OXR46075"/>
        <property type="gene ID" value="B7C42_01039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="278"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="534" mass="57428" checksum="F30A4C199FCD67B3" modified="2017-10-25" version="1">MSTLRTAIDPNSADYRTAADAMTEKLAEVEAEYAKNIAGGGPDKMARHRKRGKLTARERIELLIDEDSPFLELAPLAAWGSEFHVGASVIAGIGIVEGVECMIVAPDPTVRGGTSNPWTLRKNLRMNDIALENRLPVIGLVESGGADLPTQKEVFVPGGRMFRDLTRLSAAGIPTIALVFGNSTAGGAYIPGMSDYTVMIKERSKVFLGGPPLVKMATGEESDDESLGGAEMHARTSGLADYLAADEQDAIRIGRSIVRRLNWRKTGPAPRPRAEVIEPLYDSEELLGIVPTDLKIPFDPREVIARVVDGSDFDEFKPLYGSSLVTGWAELHGYPVGILANARGVLFSEEAQKAAQFIQLANQSNTPLLFLHNTTGYMVGKEYEQKGIIKHGAMMINAVSNSKVPHISLLMGASYGAGHYGMCGRAYDPRFVFAWPSAKSAVMGGAQLAGVISIVGRAAAEARGQAFDEEADKGMRAMIEAQIEAESLPMFMSGRLYDDGVIDPRDTRTVLGMALSAIHNAPIKGAEGFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB55</accession>
    <name>A0A231HB55_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781483.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46164">
        <property type="protein sequence ID" value="OXR46164"/>
        <property type="gene ID" value="B7C42_01129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="15994" checksum="D2FF5B65A3B3FD91" modified="2017-10-25" version="1">MNVEKLRTADDWVMFYRHHAGLTCIQRGGFVTLPVTGTVGVVHLPADRAEAVCRSLTEHGGCGPVLARRVRWSFLVFPDSRPGGQVADILQRLDIGIPAVGGEIMMPTSLGRWTREGCHWIVAPGSGLELPPLSIVVTTALAVGRGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBK2</accession>
    <name>A0A231HBK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug efflux ATP-binding/permease protein</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_01157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46192">
        <property type="protein sequence ID" value="OXR46192"/>
        <property type="gene ID" value="B7C42_01157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="903"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="684"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1041"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1251" mass="134088" checksum="349B9EE06C482AFB" modified="2017-10-25" version="1">MSRTDSAADQGWVRYLLYRCLSHPRAVAGAAVGALGSAALTAALPLVVRHVVDTLGDSRVPLAAAVTVLIVIGVLRFGLSMLRRVCSSTLSLGVQFDLRSDLFAALVRMPGREQMAVSTGQVVSRAISDITLIQMFLQLIPIVTGNAALLVAALVLMATMSLPLAGIALVLLPALWFVTRRSQRELFPANWDAQAQAAEVAMRVESAVAGVRVVKGFGQERRETGELERRARDLFRSRLRVVRITSRFTPAMAALPALGQVFILVVGGLLALHQSISLGTFLAFMTYLGSFVSPVRQFSTLLTVSQQGKASLDRVREVIDAGSGREPAAVPSPATAVAPPRIDLSGVIVRIGDTAVLDHLDLTIPAGSTVALAGGAGSGKSTLTALLPRLIDPDAGLVRLDGVDVREVPDLRGRVAIVFEDTHLMADTIRANVAYGRPEATDDQVWHALYLAAADDFVRRLPEQLDTPIGERGQRLSGGQRQRLALARALITDAPVLVLDDATSAIDAKVEQTIFERIAAEVQRRTTVVVAHRVSTLALADRVVILDDGRVAESGTLAELQESGALFATLFTPPGVAEIGAALRSTTDGVPTEILWAEPAEYGDESRTLEQMARAFSHHAAGAGGFARGGGMMTSAPPSGDVQALIDALPPVTGEPAVPETFTRTADPEFGLRRLLRPFAGPLLAGLGLVALDAIAQILIPVLVRYGIDRGVLVGARDVLLGAAALAAAVVLADWAISVAQVRVTGRAGERLLFGLRVKTFAQLQRLGLQYYERELGGRIMTRMTTDVDGLSSFLQTGLSTALTSSLTIGGVVIALLVIDARLAVVVLALMPILLAATVWFRRLSVPAYNTARDKVSAVNAYLQENVDNIKVTQAYRREARNQARFDRLSWEYRDARLRSQTLMAVFFPFIEFLSVVATAAVLAVGVHQVRGAALSAGTLIAFLLYIDLLFAPIQQLSQVFDSYQQAVVGVDRLGRLFAVEVATPQAARPRAVHRVDGAIEIRDVSFRYRPEDAAVLHDVTLRIEPGQRVALVGETGAGKSTLVKLLARYYDPSDGRILVDGTDIREFRLEDYRKRLGVVPQEPYLFGDTVRDAIAYGKPDADPAEIEWAARAVGAHEMIAGLDHGYHHPIGPQGRSLSSGQRQLLALARAQLVEPDILILDEATASLDLATEARVRAAIDVLTAGRTTIVVAHRLATAVDSDIVAVMVGGRLAEVGPHAELLRADGTYAALWRAYVGASRSEDDRESARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBM3</accession>
    <name>A0A231HBM3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46235">
        <property type="protein sequence ID" value="OXR46235"/>
        <property type="gene ID" value="B7C42_01201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234769" evidence="1">
        <location>
            <begin position="34"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="173" mass="16334" checksum="23047A0F185D8B6D" modified="2017-10-25" version="1">MRRTIGIFGRKALVAALPLAVAVTFAGAGAATAETPAAAAQPAPVAQLVTAPQAAPIARFAAAPVAQSAAAASDEAAATASDEAAAVEIAQPVAATGAEDIATNPNAANHDPLANGAAAGAAVGAVFGAVVCAATIVGIPLIPLCALGPAFQGALVGLLVGVLAPDVVPQILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC07</accession>
    <name>A0A231HC07_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46473">
        <property type="protein sequence ID" value="OXR46473"/>
        <property type="gene ID" value="B7C42_01442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18302" checksum="E56930307AE776FB" modified="2017-10-25" version="1">MSTPPEHPESDRPGSAGEFGSPEPAPRLEWSTPAPALAAVTLGGVALAVAAVFASDAPSRLLIGLAAALLLCLAGLGFRQRPRLTVVPGHPAHLVIRGLFGPVRYGPDQILRARVVGFRRLGRSIPNLELDVDHKGEERLVIFGRWDLGTHPQDVLDVMTVHGLVPAEPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC19</accession>
    <name>A0A231HC19_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781803.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46431">
        <property type="protein sequence ID" value="OXR46431"/>
        <property type="gene ID" value="B7C42_01397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="30021" checksum="984D67C78ADD06CA" modified="2017-10-25" version="1">MATYFDPKSWSPLRAVDLGRRLFDPEMLDQWTAFTTAWLDPVADLGAGTVTALMPDVLMTLLSEGILSRFGGREVTATLLGHDLTAILQTLKVRRRGAHFQTKTVLTALRWNGHPIEEMTVIAHGVRLIPGVPTKVRTAGLDVTGTVTTAALVEWLNEKRLDWRFEVHPSGLISARHRTRRFQALVDAAISDNLVTIAVHQAAWSGVRVPRRWVSVAPVTLADLPNDVRIVRADRQGDRVHFRLELPQITGSFDLGQMRAAIVAGTTLIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCE3</accession>
    <name>A0A231HCE3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pknB_1</name>
        <name evidence="11" type="ORF">B7C42_01447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781841.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46478">
        <property type="protein sequence ID" value="OXR46478"/>
        <property type="gene ID" value="B7C42_01447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="356"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="423"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="492"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="559"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="633" mass="67188" checksum="867B5040C8B45618" modified="2017-10-25" version="1">MTTPKNLSSRYELGEIIGFGGMSEVHKARDLRLGRDVAIKVLRADLARDPTFYLRFKREAQNAAALNHPAIVAVYDTGEAEVDGGPLPYIVMEYVDGETLRDIVRGKGPLPPRRAMEIIADVCAALDFSHKNGIVHRDMKPANIMINRQGAVKVMDFGIARAIADSSNPMTQTAAVIGTAQYLSPEQARGEQVDARSDVYSVGCVLYEILTGQPPFTGDSPVAVAYQHVREDPKLPSLVHPGVPRELDSVILKAMSKNPANRYQSAAEMRADLIRVLGGQKPQAPMVMTEEDRTTFLGSMEPEPRSYRTVERNDGDDEPEPESDGSRRKLWIGIGAAAVVAVLVALFWVLIGPGSRPDQVAIPDLSNQPAEQARNDLQKLGFNVAVQPKPDGKVASGNVVATQPLGGARVDKGSTVTLQISTGPQQVPVPQLTKLTQQQAEQNLNAAGLLLDPQIQRGASSPEDKDKVIAESPAAGTKIDAGSKVTITLGKGPDQVRVPDVVGQSIDVAEPNLADSAGFKVVIQKVSSSRPAGEVLSTDPAGGSMADKGSTITVQVSSDQITMPSLTGLTPSQAVDKLRSVGWTGGVGQISQSTQGTFDASNVGRVIDQQPRPGSSVARNATITIVTGVLGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCP1</accession>
    <name>A0A231HCP1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775337.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46733">
        <property type="protein sequence ID" value="OXR46733"/>
        <property type="gene ID" value="B7C42_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="109"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="18667" checksum="42E33B714F2CFB85" modified="2017-10-25" version="1">MTNPGDSDEWWKQYGGEGVSSDSGGHQSVPPTPPQQPTPPPNPQAGYSSAPHQQSSPYQQPTPPPQQQQSYPSYPQQQPYGQPGYGGYPAATPYQPYGYAAPQQGTNGLAIGSLIASILGLCTCIGSIVGIILGVIALNQIKERGGQGRGMALGGIWVGAVGIVLTIVWVIVNIAAANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCP6</accession>
    <name>A0A231HCP6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent decaprenylphosphoryl-D-2-keto erythropentose reductase</fullName>
            <ecNumber evidence="1">1.1.1.333</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dprE2</name>
        <name evidence="1" type="ORF">B7C42_01559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.333" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46588">
        <property type="protein sequence ID" value="OXR46588"/>
        <property type="gene ID" value="B7C42_01559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="27080" checksum="BB908896B1D20FD9" modified="2017-10-25" version="1">MINAVGNPQNILLLGGTSEIGLAIVEEYLKKGPARVVLAALPNDPLRARSVAQLEAAGASKVEIVDFDALDTGSHPKVIEQAWAEGDIDVAIVAFALDGDAEELWQNQLKAVRVAEVNYTAGVSVGVLVGEKMKAQGFGRIIVMSSVAGERVKRANFVYGSTKAGLDGFYLGLGEALRPHGPRVTVVRPGQVRTQFSAHVAEAPLTVNKEDVAALAVSASEKGKELVWAPGTFRWVMMILRHVPRPIFRKLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCT8</accession>
    <name>A0A231HCT8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative arabinosyltransferase C</fullName>
            <ecNumber evidence="17">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">embC_2</name>
        <name evidence="17" type="ORF">B7C42_01556</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the emb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="17"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46585">
        <property type="protein sequence ID" value="OXR46585"/>
        <property type="gene ID" value="B7C42_01556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052636">
        <property type="term" value="F:arabinosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071766">
        <property type="term" value="P:Actinobacterium-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032731">
        <property type="entry name" value="Arabino_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042486">
        <property type="entry name" value="Arabino_trans_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007680">
        <property type="entry name" value="Arabino_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040920">
        <property type="entry name" value="Arabino_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027451">
        <property type="entry name" value="EmbABC_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14896">
        <property type="entry name" value="Arabino_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17689">
        <property type="entry name" value="Arabino_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04602">
        <property type="entry name" value="Arabinose_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Arabino_trans_N" evidence="16">
        <location>
            <begin position="24"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Arabinose_trans" evidence="14">
        <location>
            <begin position="184"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Arabino_trans_C" evidence="15">
        <location>
            <begin position="683"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="762"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR46585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1071" mass="114201" checksum="2F3604E69DE89F0C" modified="2017-10-25" version="1">MIALLSGLIAVALAVLTPLLPVREDRASLDWPQPQSVPVNAPLVSYVPLTVDASLPCSALRELPSGTVLSTVPADAPNASAKGLIAKVADEPGGRTLSVRLRDIPLLSAPLAEVGGCARFVVTSTAQATTAEFTGVTRQDGTPFTNTVGGDVRPQIVGVFTDLTREQLGDAHLHAAIDSRFSSTPSPLKLAAIIGAVVFTLIALICLHLIDTADGRRPRRFLPAHWWRVTVADVVVLGTLVVWHVIGANTSDDGYILTMARASKHSGYMANYYRWFGVAEAPFGWPYEVLAWMTRVSDAGWWMRLPALLAGVLCWLVISREVLPRLGSRVRRDTVALWTAGLVFLVAWLPYDNGLRPEPLIALGALLTWCSIERSIATRRLLPAAVAVLIAAFSLAAGPTGLICVAALVAGSRPVLQHIISRARGGGSAGASILRYGALLAPGAAAGALVLVVVFADQTLATVMEATRVRKIIGPNVAWFDERTRWDSLLMLAPDGSLARRFGILGMLLCLLVCVLVMLRKNGRIPGTSKGPSARILGIVFMSLLLMMFTPTKWTHHFGVYAGLAGSLAALTAVAVGINGIRARYNRSLFAAAVFFLLAITFTGSNGWWYVSSYGVPWYDKAPLIAGKGLSTLFLGLAVLSLLLAAYQYYREPYRKANGRRRFDTWAVQPLTIAAAVMVLFEVASLGKGAVTQYPAYSVAKSNIRALGGHPCSLADAVLTETDTADSLLQPYSGSAADALGADSTGFDPNGVAKDLTADAEETTTGGANSVNTDSANKTTHTTTAGTGGGTTQQVGVNGSTVALPFGLDPARTPVLGSYTTGTKQQAHLTSGWYRMDLSGARQDPDRKVLVVTAAGRIKSVNADGVVTYGQDLRVEFGDRAADGTVRPLGSFVPLDIGGAPSWRNMRVPLDRVPDGTNAVRIVAVANDLTPRQWLAVTPPRLPKLATLDSVVGHTDPVLEDWHVGLAFPCQRPFDHKDGVAEVPKWRILPDRVGSDASNAWQDDIGGGPLGWTGLLLSAQTIPAYLNDDWGRDWGSLERFTPYVPQARQADVGVTVQTRWGWVKDVPIKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCV1</accession>
    <name>A0A231HCV1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46669">
        <property type="protein sequence ID" value="OXR46669"/>
        <property type="gene ID" value="B7C42_01644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16546" checksum="401EDC86FF079743" modified="2017-10-25" version="1">MTTPDVPTFAQVTDVTSTWRTLSDAQIAYANLLLQAAALWIRNRLPNIESDSPAAKIVSIEVVRAALQRDQLDGVPSGKKTRGSRSDEWTNVRTATIQELAQTLVFSQYHYQLLGIRQPSGPRYGMGSGLRGPDPIRLRGYDGMTGWGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCZ0</accession>
    <name>A0A231HCZ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46567">
        <property type="protein sequence ID" value="OXR46567"/>
        <property type="gene ID" value="B7C42_01538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="17608" checksum="CFF8B64F1A0BAE12" modified="2017-10-25" version="1">MAYPYMQPAYAPPAPKPGGGTAITAGVSALLQGIALTVFSVLGAIATRQDRRSGYGSTEDLVALIIFGSLSSLFLVGAILLLCRRKSGRFIVVAVTSLVLLVVPVFPVVAAIGGGVEKSDVVGFAVMLALLFTVELPTLVCAAMSSTGRWIAARTVKTHVPPPPVYPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD15</accession>
    <name>A0A231HD15_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46686">
        <property type="protein sequence ID" value="OXR46686"/>
        <property type="gene ID" value="B7C42_01661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13708" checksum="6296AC776C8AD44E" modified="2017-10-25" version="1">MSGKFGRGAAMAVTVAIDATIIAVMAPDYNGAANVFWMLLTVKAWVFVLLYGFRSHWWITRGGRGIMRLVSCIALIGTLSTGTILLGDYPGRPFVRLALIAFVALAMMDLLLTLVAAQQDDDSDITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDG7</accession>
    <name>A0A231HDG7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46919">
        <property type="protein sequence ID" value="OXR46919"/>
        <property type="gene ID" value="B7C42_00033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="7055" checksum="D8E92982AA3CB6CC" modified="2017-10-25" version="1">MSAVCPNPPRTRPRRRLAREIRASGVAVTLVVHEHKRPGRGIELAASAELLKAADIGLEFLTGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDJ4</accession>
    <name>A0A231HDJ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">H(+)/Cl(-) exchange transporter ClcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">clcA</name>
        <name evidence="8" type="ORF">B7C42_01813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46835">
        <property type="protein sequence ID" value="OXR46835"/>
        <property type="gene ID" value="B7C42_01813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="509"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="593" mass="61970" checksum="3278AD4DD13A1B55" modified="2017-10-25" version="1">MSAGHSRATHLGDFQVSPRLLLIAGLAIPVGGAAAVAAFALLKLIGFITNLVFYQRFSTEMVAPGATHHPWWLVLTAPVVGGLIIGVMARYGSEKIRGHGMPEAIEAILTGGSRVQPRVALLKPASAAISIGSGGPFGAEGPIIMTGGAVGSILAQLLKLSADERKTLLVAGSAAGMAATFNAPLAAILLAVELLLFEWRPRSFIPVVAAVVTGTICRWAMLGNEPVFAVATDGRTPGALSDGLALIPGMTGGLLAIAATAMVYFAEDSFAKIPVHWMWWPAIGGLIIGIGGLFEPRALGVGYDVIDQLLTGHATLSLIAGILVVKTLIWSLSLGSGTSGGVLAPVFMIGAALGAAEGGLLPHVTAGFWAMCGLAAVVGGVMRSPLTGIVFTCELTHAWNDVLPFAVASVSAYAVSVLLLKRSVLTEKIARRRLHLTREYTTDPLETFFTHEVMTADPLVLGIDDLIDPILSRTHDAGLYPVVDGCGALVGVTTRQVLQNSPGTTVGAATLDIRTSVHPDNTLREVANALALAHVTAAPVVARDDPNRLCGIVTLEQLLHARRRDLHEEHHRERLLVVRDEPVAGDDDKVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDP8</accession>
    <name>A0A231HDP8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ettA_1</name>
        <name evidence="7" type="synonym">ettA</name>
        <name evidence="10" type="ORF">B7C42_00180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47060">
        <property type="protein sequence ID" value="OXR47060"/>
        <property type="gene ID" value="B7C42_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="322"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="558" mass="62139" checksum="03DF87690956F94E" modified="2017-10-25" version="1">MAEFIYQMKKVRKAHGDKVVLDDVTLNFLPGAKIGVVGPNGAGKSSVLKIMAGLDQPNNGDAFLAPGATVGILQQEPPLNEEKTVRGNVEEGLGEIKVKLDRFNEIAELMATDYSDELMEEMGKLQEDLDHADAWDIDSQLEQAMDALRCPPPDEPVGNLSGGERRRVALCKLLLSKPDLLLLDEPTNHLDAESVNWLEQHLAQYQGAVLAVTHDRYFLDNVAGWILELDRGRAYPYEGNYSTYLEKKAERLEVQGKKDQKLQKRLKEELAWVRSGAKARQAKNKARLGRYEEMAAEAEKMRKLDFEEIQIPHGPRLGNVVVEVEHLDKGFGDRQLIKDLSFTLPRNGIVGVIGPNGVGKSTLFKTIVGLEQPDSGEVKVGDTVKLSYVDQNRAGIDPKKTVWQVVSDGLDYIEVGNQEMPSRAYVSAFGFKGLDQQKPAGVLSGGERNRLNLALTLKQGGNLILLDEPTNDLDVETLGSLENALENFPGCAVVISHDRWFLDRTCTHILAWEGDDSNPAQWFWFEGNFEAYEANKVERLGPEAARPHRVTHRKLTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDV4</accession>
    <name>A0A231HDV4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47111">
        <property type="protein sequence ID" value="OXR47111"/>
        <property type="gene ID" value="B7C42_00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9806" checksum="66B007FF5921071D" modified="2017-10-25" version="1">MVDKRKLSRRLMSSDWGKVGERAVVGFQCSLAIGVLILLSVHLVPVLVSVRSDGTRFLIALLLGLLTSIALDPTVRYIRTIWRGDRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE33</accession>
    <name>A0A231HE33_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47036">
        <property type="protein sequence ID" value="OXR47036"/>
        <property type="gene ID" value="B7C42_00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="393" mass="41312" checksum="561FEFC63CB3A2E8" modified="2017-10-25" version="1">MSADIFEHRALISGIGQSAIARRLDRSGLQLTLDAVLAAVADAGLTVDDIDGLAMFPGGGVANLPGYANGNLYEVQDALRIETTWRQGLVEGMALPFYGPAQAVATGQARHVVIWRTVKEGSAARDAGGRPAYGSTKPLAEGPQAWLLPVGMLSPVCQIAPFATRYMHEYGLTRERLAWIAVAQRAHAAHNPDAVYRSPLTVDDYLSARMISSPLCLFDCDVPADGATAIVVSAAETAADLRAPVRIEAMAGVVDGRPAWDQWEDMGRVGYATAAALWARTALTPADVDTAQLYDGFSIEAVWWLEAMGFCGTGEAGDYLDGGTRIALGGELPLNTWGGQLSGGRLHAGFGHTAEAVRQLRGEAGARQVAGAEVAAVTNVGGIESGAALLTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE77</accession>
    <name>A0A231HE77_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47250">
        <property type="protein sequence ID" value="OXR47250"/>
        <property type="gene ID" value="B7C42_00372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="797" mass="78444" checksum="D6C0EFA137A96141" modified="2017-10-25" version="1">MTRELPFDDDADAGDHANDAAYRVATGVARVARAGAYVTGGALIASNGSPAPENESHNSHITGWSTADPHPDVPSPVVTYPDPSPDSVPPDLGTSTPRHTPAAPAPGLALPEHHGTDAFPGLQFPQGSQSPLTFGEFPGTTGGESPDSHFPFPESNHGFGGNGVFDSPGFGGGHGLSMPGLHTSSAPFGFGAEGSGPASSASGLDLPGAARTTDEQRDDSDLSGTDPHPTTPLLGHGLGLPGTNGLHLPGMNGLGAGGFGSGNGLQDGHGAFDGIGDGGGPGIFLGTEMKVDAHIGFDGVWVTTETKVDFAVGDVGHQLDDYGNWLGNSAHQFPGFTPQSDATAAAGQSVGAADVTRAAGTSADGMTVPAPGATASATQSGAAHPASAAGSAGTAANGAAAPGSSAFAPQSGPMAASAAPGTASFSTAQASAPVTNAAASQPVSTAPVVAAPAPVAPAPAPAFVQPVAATPLQTTIQPEAATHPIANVITTHAGPSPLTAPAVAVPALFDDRPRHTDAGLPGGGANDPSDGAGRSTTHTPTTTSHGTTTTHGTDASKTPAVPSTSHAPGTTPGGEHTTTRPGTSTGRDSADHDSTDRPTPTVTVPRDTDSGHPTRTPGTTPSDPGSDSGPSTSAGADASTPGHTATHTPGTSSGADTSASGDADGSTAPTHGSQLPTHDPDSVPTQQIPTQQSIPPSHDPTIPTHEPTVPTAQHTAPVEPPTVIKPPTTIDPAPNAHVPVKPVAAVTDSYDTSLWSDSAHGLATVSAAGLSGGLHETTFAETHYPVDHPVDFHVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEE0</accession>
    <name>A0A231HEE0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribBA_1</name>
        <name evidence="13" type="synonym">ribBA</name>
        <name evidence="15" type="ORF">B7C42_00341</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47219">
        <property type="protein sequence ID" value="OXR47219"/>
        <property type="gene ID" value="B7C42_00341"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="211"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="204"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR47219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="413" mass="44217" checksum="0AC317E26D3A07F6" modified="2017-10-25" version="1">MTGELDSIQNALDALAAGRPVVVVDDEDRENEGDLVLAAEFATAQTIGFLIRHTSGVLCVPMPGADLDRLSLPPMTAINEDPKGTAYTVSVDAAAGVSTGISAADRAHTMRLLADPRTTPADLTRPGHVFPLRAHPRGVLGRAGHTEATVDLLRAAGLRPAGVIAEVVNDDGSMARLPQLLVFAREHGLPIISIADLIEYRKRREHTVTRLAQTRLPTRYGDFQVFGYRDADSGTEPIEHLALVFGDPSGTDVLARLHSECLTGDAFGSLRCDCGEQLDAALRAVAAEGRGVVVYLRGQEGRGIGLLNKLRAYELQDAGADTVDANLRLGLPIDARRYGAGAQILSDLGVESVRLLSNNPDKQAGLQAHGIAVTRRIPLQTDPTEHNVRYLRTKRERMRHQLAGLDVASAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEL0</accession>
    <name>A0A231HEL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47292">
        <property type="protein sequence ID" value="OXR47292"/>
        <property type="gene ID" value="B7C42_00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16790" checksum="0C58D745A420CBEA" modified="2017-10-25" version="1">MRTHIVRRAYDPGVKWMSRAFGSKELPPQVRSDLESEGIVVFGPVSGSLARRNYRTPLHYGSSSWENIVGGTIGMSRKRLVIWGNQEALVDVWLGHPAVTMELQGPERMLVEADRGAIDPIRTGWTTLMLRTIHAPRIAQLYAEGLPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEP8</accession>
    <name>A0A231HEP8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroanticapsin 7-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.385</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bacC_1</name>
        <name evidence="2" type="ORF">B7C42_00455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.385" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47332">
        <property type="protein sequence ID" value="OXR47332"/>
        <property type="gene ID" value="B7C42_00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="24139" checksum="6895F4C44C5C62B3" modified="2017-10-25" version="1">MNQPTRPLGNVVITGGASGLGAATVHAVRAAGGVPLVIDRNRPDTDVDWEHADLADSAAAEEATRALADRAGGRVDGVFTAAGIDACGPLEKVDAAAWERVVRVNLLGTAAVIRAALPALRASRGHVVTCASTLGMRALPDATAYCASKFGVVGFTRALAAETAGEIGVTLLIPGGMDTHFFDDRPEQYVPGPDVRLERPENVADAVVFALTRPAGSEVREMLVCSSTESSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HER9</accession>
    <name>A0A231HER9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47430">
        <property type="protein sequence ID" value="OXR47430"/>
        <property type="gene ID" value="B7C42_00553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="23705" checksum="E582099BCB00C2CB" modified="2017-10-25" version="1">MHTETLRRTAGIAAVCGAALMLVELPLYFVYDGPPPDWNILTRGLIGLAGLLAVVVFLSTFGHLVKAADRRYEWLGSLASTAGLMWTTVAFVSMGLEIGATIQAPEPIDPTVTVSGTYVLYGTVSRLLTALFMATAAVTILRTRILPAWVGRSAAVLAVVNVAFVPSMFFGNTPANFYAANGWGTTATVSGFTIIWLLGAGIALLTSASPRAVPGSSRAVASQLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFB2</accession>
    <name>A0A231HFB2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">pnp</name>
        <name evidence="10" type="ORF">B7C42_00786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47661">
        <property type="protein sequence ID" value="OXR47661"/>
        <property type="gene ID" value="B7C42_00786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014069">
        <property type="entry name" value="GPSI/PNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02696">
        <property type="entry name" value="pppGpp_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="667"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="761" mass="80545" checksum="4F17B84985215B65" modified="2017-10-25" version="1">MTESQTSSAIEVEPGVFESVALIDNGSYGTRTVRFETGRLAKQAAGSVVAYLDDETMLLSATTAGKHPKDQFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVDGLRNEIQVVVTVMSLDPNDLYDVVAINAASASTQIAGLPFSGPVGGVRVALIQGQWVAFPTVEQLEEAVFDMVVAGRVVESGDVAIMMVEAEATEKVIALVEDGAQAPTETVVAEGLEAAKPFIARLCKAQADLAALASKPTEDFPLFPPYEADVYTAVEGTAKNPLSEALSIAGKQEREERIDEIKLEVLSALAEDFEGREKEIGAAFRSVTKKLVRQRILSDGFRIDGRGLADIRALSAEVAVVPRAHGSALFERGETQILGVTTLDMVKMAQQVDSLGPETSKRYMHHYNFPPFSTGETGRVGSPKRREIGHGALAERALVPVLPSQEEFPYAIRQVSEALSSNGSTSMGSVCASTLSLLNAGVPLKSPVAGIAMGLVSDEVAGDNGESETRYVALTDILGAEDAFGDMDFKVAGTRDFVTALQLDTKLDGIPSKVLAGALNQARDARLTILDVMAEAIATPDEMSPYAPRVTAIKIPVDKIGEVIGPKGKVINQITEDTGANISIEDDGTVFVGATDGPSAQAAIDAINAIANPQLPKVGERFLGTVVKTTAFGAFVSLLPGRDGLVHISKLGNGKRVGKVEDVVNVGDKIRVEIADIDNRGKISLVPVAEEEAAEASAPAADEAPAAAEAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFW2</accession>
    <name>A0A231HFW2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47729">
        <property type="protein sequence ID" value="OXR47729"/>
        <property type="gene ID" value="B7C42_00854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="35963" checksum="697622ADE11CCC55" modified="2017-10-25" version="1">MIITQQCLVSSTSRAARRADTLAPMGARLRTARKLLLGREIDHMISAAGVNQAEAARIIDTSQSRIAMLINGASSITVGDLERLAVALGFTDPGYLESLEALRRDNHKRGFWNTGHRRAYLEELRLLVDLEAHASLLRVTEAEIVPGLIQCESYIRALHEPPHDAQPPSTAPCAVTVEDSVRARLARQDVLTGPGAPRFHAVLSESCLRREYGGRAVMADQLEYLLELSHRPNIILQVLPFTVATRGAGMEDRFTLVRVPSPGAAGDLDMAIVESQGDIRYIDDKPAVRARETVWDRLSAAAADPDRSRAFIDRIARSFRRESVTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGH1</accession>
    <name>A0A231HGH1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782842.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47795">
        <property type="protein sequence ID" value="OXR47795"/>
        <property type="gene ID" value="B7C42_00920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038762">
        <property type="entry name" value="ABM_predict"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40057">
        <property type="entry name" value="PTHR40057"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="111"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="322" mass="36270" checksum="1CC85DA10EB877E2" modified="2017-10-25" version="1">MPRETPDGHAATVIIGEKVRPGCEEAFLAWQHGLNSMAAQYPGFIAAEIDPPAHPQAHWSLIYRFDSIPNLRAWINSATRQDSLAEGRRYLDGPPTQQIVTGAAAPPDTLVTAVVTHRVVPEQIDEFLAWQERLRHAENEFPGFRGSEIFRPIEGVQDEWTMLYRYDSAADLDRWLTSSARQRLLDEGKRFSDFRLRTIDNSFGSWFAFDEDGPAHAPSQTKTSIAVWVGLYPTVVLLSLALAPAGMPLWLGMLIGNLLSSFVMTFVTMPRYVNPLLERWLQPAPGSQRKAIEIRGAVLITAVMAFWTVLFWLVTTVFWHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSN3</accession>
    <name>A0A231GSN3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000111">
        <property type="protein sequence ID" value="OXR39640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39640">
        <property type="protein sequence ID" value="OXR39640"/>
        <property type="gene ID" value="B7C42_08292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="11805" checksum="2D1CF188F36E50D3" modified="2017-10-25" version="1">MSSETMFSVYGRMTALPGRRDELIAVLLAGFRAGGDDSGLLHFSINRAFDDPDTIWLNQLWRDKEAHDVSTRSEPVAAVSRQVPPLLAQQPDGAYGHTVHVGGRLTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTB6</accession>
    <name>A0A231GTB6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043523.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39818">
        <property type="protein sequence ID" value="OXR39818"/>
        <property type="gene ID" value="B7C42_08106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12116" checksum="227115EF418525DD" modified="2017-10-25" version="1">MITATEGRRIVHTRCGGRCERCGTAGYTVHHRRKRSQGGTWDPSNLLALCGSGTTGCHGWVEANPAAAMDLGFWLANGETSADTAVWLWRRWVLLPDDEGPLLASGSKYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTF1</accession>
    <name>A0A231GTF1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782361.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39900">
        <property type="protein sequence ID" value="OXR39900"/>
        <property type="gene ID" value="B7C42_08005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="10502" checksum="FCEDE0D2B32523B1" modified="2017-10-25" version="1">MPLTQGRYGDSTGHHRLFWLRHNTVQLLRSLRRDPRDTGGGYTMHREWGAWVLRPVSGWRALRWITPPADATRSVNDRDAALDYYAAKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTK9</accession>
    <name>A0A231GTK9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782307.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39885">
        <property type="protein sequence ID" value="OXR39885"/>
        <property type="gene ID" value="B7C42_08031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="18240" checksum="EB99A25AFD46F2EB" modified="2017-10-25" version="1">MDPVATVIGLALTRLRQVFAPDASAPPLGGGTDTVYILAGDTGIIPEWVGTNSDSCDDCGPYIWVRLVRRWRTTEFPTESVTADCGAQKAITIEAGIARCHPVDADAAELEQLAAVQWDDAWRIDLALCAAMGDAEAAGRVGRAALGPGEPFGPEGLVIAWTQLAHAEIAGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTQ9</accession>
    <name>A0A231GTQ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39935">
        <property type="protein sequence ID" value="OXR39935"/>
        <property type="gene ID" value="B7C42_07998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10388" checksum="6D91158422B197FD" modified="2017-10-25" version="1">MNSLDYTRHHTGLAAFGRPEFDAAGLVQAGMYATPPKWRLIALAAAVCFGAGIVFGIMLGQGSPNYAPSPNVCRADEVSRIDCVHVVPTTAPAESGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTU2</accession>
    <name>A0A231GTU2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782359.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39901">
        <property type="protein sequence ID" value="OXR39901"/>
        <property type="gene ID" value="B7C42_08006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011269338" evidence="1">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="14964" checksum="9D3365E63A01AD3F" modified="2017-10-25" version="1">MRRIGSIITAAATAVLLASAVQAGPAQAAAKACDLGFMPTKPTVGVGSIIGNAWVKCDVAPERHELRLGLQIRTGGSWKTDQLISDATIPYPRATYGVKASCTPGLWRVQAQAVGSLSGHPFDFVDYSMERFVTADDCARGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTW7</accession>
    <name>A0A231GTW7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40056">
        <property type="protein sequence ID" value="OXR40056"/>
        <property type="gene ID" value="B7C42_07860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="36280" checksum="9168CDC3167F4AE2" modified="2017-10-25" version="1">MELVVGEQPEFEWRPELEVTVTENLLMTVALARAAVSAIAIAGQTITYGKLATALDDRFNYRRPGVILDLLSLDCIRRDEPSLAALVVQASTGRPGDGYVHGDVPIKKYQRQSKSSGSSHTGESWTGSGAGQSPEIRRYGVPAPAGDSERRPHTPLCGVGVGLDEFEVGFAFPCPAVSRPPEHHPVRAAGGRGFRAHLNDFAGGVVEVGADHRGVPGRGDITDPVATGQAGTRLQPDPGSRRDGHRSSLSPAPAARPGWDSRGMGDVFAVGDRIEWWSDIDGGPAEPGDPAAKKHTGTVASVHRNPNDDTQVVAYLVTSRSGVAGTYTTTVRPDLHRPTAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTX9</accession>
    <name>A0A231GTX9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3 9">2.7.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apbE_2</name>
        <name evidence="10" type="ORF">B7C42_07832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3 9"/>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40077">
        <property type="protein sequence ID" value="OXR40077"/>
        <property type="gene ID" value="B7C42_07832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="308" mass="32211" checksum="9A3D0017C0BB8907" modified="2017-10-25" version="1">MTSVPAAETAAAEWELWSTTARLVVTDPAALAAARRLVDAYLDRVDHACNRFRADSEISTLTPGRPATISALFDDYLDAALTVARDTDGDVDPTLGADLENLGYDRDFTQITAGPTVVALRITPRPDWSQVIRSPRAVTLPAGVRLDFGATAKALAADRCARTVADALGCGVLVSLGGDIATAGPAPGGHWQVLVQDGATQPAALVRLPAGAAIATSSTVRRRWIRGGRPLHHILDPRTGCAAEPVWRTVSVAAESCLAANAAATAAVVRGRAALPWLRSAGLPARLVGRDGRVLTLGGWPDEPEGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU61</accession>
    <name>A0A231GU61_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40021">
        <property type="protein sequence ID" value="OXR40021"/>
        <property type="gene ID" value="B7C42_07905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="473" mass="45843" checksum="868B034058AB8D37" modified="2017-10-25" version="1">MTTSIAAVNHAQLPDIVCDLPTGPGAVCALKQLGGKAANSAANSAFDDLVDKLVASLTSLIRVLMTWWVNLPAPQLAGRGGEPGPALASIRGYTSGLQVLLMIAGILFAAARLAMARRGGVAGEAQESFLMFARAVFASMMFAALITSGTKAGDAFGNWVINDATGGDLHGAVERLVDNNLRDHSNLGSGVLLVLAILGLISMLVQLAMLVIRQAVLILVVAAIPLAAAAAGTGPGSQAYKRMLSWSLAFVLWKPVGALIYAIAFTAAGTKFTGQQQDPQLVLLGMILLLSVTIVLPALMRLVAPAVVTLGGGGGAGAALAGGALGIAMGSAGGDRSAARKMIEGENATTSGGGGGLNPPPSGPSGGPGGGRPLSGGTAGGGAWSGGGSAGGGSSPGGSASAGTGSRSAGAAGQAGGGSGAAGGAPAGAGMAGAAVMGAQLAGQGVQSASSAVESQAGDSWDIDAPGPLEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUC9</accession>
    <name>A0A231GUC9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M78 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000039">
        <property type="protein sequence ID" value="OXR40145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40145">
        <property type="protein sequence ID" value="OXR40145"/>
        <property type="gene ID" value="B7C42_07769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="29792" checksum="F8414D5D9145654A" modified="2017-10-25" version="1">MLRRSGRKPAVYHRSLPRGPLHSYRQRFTLAHELGHLKLAWHLGNKACEMPGTGPSENAAVHRYLEEQEADQFASCLLVPDRWLVELISSYGHDMDGMLGAIAVAKVSTTASLLALRRQLSVGWVFQINNQQNLLTSRGTALPGGLADAAQDHGCTELHKNKVRWWRLTAPFAIPPEDQGPRQTPDLLRGAIRSCERDHAEQKRIEQSANGIVGGGANQDAGKPPAEVFAALAYRFQRVDYVPITQHPDFHLWLARKARAVAAKPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUL0</accession>
    <name>A0A231GUL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40272">
        <property type="protein sequence ID" value="OXR40272"/>
        <property type="gene ID" value="B7C42_07697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="15626" checksum="E22E4D81908E2618" modified="2017-10-25" version="1">MRSQREQYVEVINELDRVGQAPTAAELEPLCERTARLDDELTAVTDRGERHELDKLSREANTLLRNAYARGRIALDVADAARAREIHDALYPNHLSPHRLPTNNHPERGGPINAFALAARREREELERPGPWDGFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUR3</accession>
    <name>A0A231GUR3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_28</name>
        <name evidence="2" type="ORF">B7C42_07533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783518.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40367">
        <property type="protein sequence ID" value="OXR40367"/>
        <property type="gene ID" value="B7C42_07533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="29751" checksum="EE31078BBB3F221F" modified="2017-10-25" version="1">MAAPSVPTDRAAGRSAVGEIREWGAGYLRRHPGASLETVGGQFVLSVRAIQYLTADMVRGRFPFREFVQQAVFMAKTAYVPTVAVALPISATMSIQFGLLAGQVGATSLAGAAGGLAVIRQAAPLVTAILLAAAVGSAICSDLGARKIREEIDAMEVMGVSALRALVVPRLAACVVVAIGLTGLSAFVGFLAGYLFNVYIQNGTPGSYLATFSSFARVGDLWLAMVKAVVFGVIVTVVSCHKGLTTKGGPGGVANSVNAAVVATIILLMLVNAGFTELYTILFPRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV67</accession>
    <name>A0A231GV67_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-CoA:(R)-benzylsuccinate CoA-transferase subunit BbsE</fullName>
            <ecNumber evidence="1">2.8.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bbsE</name>
        <name evidence="1" type="ORF">B7C42_07503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.15" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40445">
        <property type="protein sequence ID" value="OXR40445"/>
        <property type="gene ID" value="B7C42_07503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033877">
        <property type="term" value="F:succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="43592" checksum="1D77E50EEAAA1B5E" modified="2017-10-25" version="1">MDNSRASNLPGPLRGLKVLDLTTEIAGPYCTKLLADFGAEVVKVETPGAGDPARHSAPFPSNRKPGTAGGLFLHLNTNKSGITLDLGRSLGRDVLRRLVRQADIVVENFPPGTMAELGLDYSDLQSLNSSVVLTSITGFGPIGPYRDYHATDTILFALGGWMATQGEPDREPLHAGGSFVSYLAGEHAAFGSVLAVLAAEASGVGQHVEVSMLEVAVNSLLYDTVGLSYTGRVRQRQGNRFGAPWLAFPVRDGYVGVTKIRAWDEFWTILLGTDDIPRNPLSTADPDERERLTKQLVECVEHIDKRHFFETAQMLRVLACEIMELDEVLNSPQYESRGYFRTIPDAAAGDLVYPGAPARLPASPWRLDRPAPGLGADTARILSTWLGVGSTELRELELQGAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVN7</accession>
    <name>A0A231GVN7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40676">
        <property type="protein sequence ID" value="OXR40676"/>
        <property type="gene ID" value="B7C42_07234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="125"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="34191" checksum="77F11750DA1BD540" modified="2017-10-25" version="1">MKILVLGGYGAVGTHVVTELRRTGVTAVAAGRDPARADTTVDLADPLLTGYRAAPAGADACAFVACRTFPATKSPWAEPRDARIGRRHRSDRSLSPMSISATAVRMGGEGRDRARPRNREEQAMRTITATMNVTLDGVVQGLGRADEDTRGGFPFGGWGQRFHDEVLVREMGRDMAEPGDMLFGRRTWEDFTTVWGRADDNPYSRHMNAATKYVASTGLNDVGAWQNSILLRGDATRTVRDVKSRPGRNLSIIGSAALVRSLHGAGLIDRYTLVIHPLTLGAGTRLFEGAAPLTEFRLLGSVATTTGVIIARYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW92</accession>
    <name>A0A231GW92_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40866">
        <property type="protein sequence ID" value="OXR40866"/>
        <property type="gene ID" value="B7C42_07001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="15547" checksum="649534CF39C87E45" modified="2017-10-25" version="1">MTIDDGRAVRVQAPTAKRPSQLKGGLSAFDRFATAACGVASRATFFAFCVLLVAVWLPSFVVLPSLDSWQLLINTVTTIITFILVALLQNTQARANAAVQHKLNAVADALADLMGELGDEHPRLCRHRAELTAAVGLEHHVSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWS6</accession>
    <name>A0A231GWS6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor RshA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rshA</name>
        <name evidence="2" type="ORF">B7C42_06833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41063">
        <property type="protein sequence ID" value="OXR41063"/>
        <property type="gene ID" value="B7C42_06833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="11810" checksum="E2D13891669DFE90" modified="2017-10-25" version="1">MSTSGHEHDDRGAGDEMELDCSAVLTDVWLILDGECDEATRARLQHHMDHCSPCIEAYGLEEKLKRLLSRKCGGDRAPESLRERLTLDIRRSITITETRVDRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX93</accession>
    <name>A0A231GX93_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41121">
        <property type="protein sequence ID" value="OXR41121"/>
        <property type="gene ID" value="B7C42_06891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="508" mass="55479" checksum="056FDE580DA59A84" modified="2017-10-25" version="1">MSRVTALLRLEAMETMRAVPITQFRHRRLSSQPLVVVPLAMAGEAGAPLAAIVGRARHAPTLLVVEQPRDRVQRFVFAADLGRKVMEHIDSCRVDRPDNPTTKNAARSYYTDAPQILVPNPGGIAFLANLGRACRFRETGGDYPVPAGVPEFGRWLTFLADSAEQTGTSMLMAVTDLLAEHWATGQSSLEDQNLASLTAWIAPPARIDVEQAILDAEDPTLWPPAGPVTDPTFDTNVLYPALRDLDEARALGDQSALSAARTELRELLSEQINPTWRMMWQAISLLRAVPEAPSVERRFVGDRARFTAFSDHQDSTDARPQPARDGAVAAARRLARLERALADFEAETAMDDPFVLADRRSIGEAFAGEVIDTEPGRVVRSGKNRRTLRPLVTIRTLDPTRLADGTELISPHMPSGHKATIVSTVREEPVSLVTVEVTAGMGTPKTPKPEAVPDLGCCLAYLPNPGWRPNPVFPDRDDTPWTHINPAVADSDGAIPDDISAEEWGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX96</accession>
    <name>A0A231GX96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein EutQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eutQ</name>
        <name evidence="1" type="ORF">B7C42_06624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41226">
        <property type="protein sequence ID" value="OXR41226"/>
        <property type="gene ID" value="B7C42_06624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06249">
        <property type="entry name" value="EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="125" mass="13349" checksum="320498758FD7E419" modified="2017-10-25" version="1">MSQATVNLAPAEAKYTFDNGPMTVELCTVRKGLDDLGGGFIRFDNGGKTDPWRLPYEEIIVVISGELTLHVEGGESITAPAGAVVTIAKGAGVVYEGTPGTRGFYALTPADWHKRYPHGLPETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXF7</accession>
    <name>A0A231GXF7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41268">
        <property type="protein sequence ID" value="OXR41268"/>
        <property type="gene ID" value="B7C42_06666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="123"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="40573" checksum="BB0258D370CBDBD8" modified="2017-10-25" version="1">MTNTLNRSRVHDAGVGVAMIALLLALTALAVAVYKDAFTSTAKVSIRTGRTGLMMDVGSQVEMSGKVVGRVTAVSFHDSSATIDMAVRSDQLKWIPANVGADLSTSTLFGRKYVSLVRPADPSPKRLADGAVIDARQVTVEFQDVLGKLMGVLQQVDPAQVDTVLTQSAAAVRSRGGGLGESLQTLSAYLSEFNGTMPTLQRDIPKLADNADTLSGLAPDLLAVLDNVSVTGPTLTDKQSVLAAFLMSFTGLGNVGTTFFDAARKPLPGAVDALDPVTGVLAEYSPEYQCLLSGLVQSDAYLKRTLGGARPGLNILGTVPMGDPPYTQQNLPQIGGVSNSPSCYGSHDGVTGADPGHTDFDDGSRAYEIPAHPSPSAANIAELLLGRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXN7</accession>
    <name>A0A231GXN7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multidrug efflux ATP-binding/permease protein</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B7C42_06527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41384">
        <property type="protein sequence ID" value="OXR41384"/>
        <property type="gene ID" value="B7C42_06527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="844"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="55"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="368"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="738"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="401"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1097"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR41384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1330" mass="140890" checksum="63D88EAFC2911DA1" modified="2017-10-25" version="1">MNDTETLDSGSGRDAGSAAAPPSREPSRRARDAGRGGWLRRLWTACRGHPRVLTGVIAAVVAGAGAEAAAPLAAKAALDRARLGEVGALAPIAGILVALAVARFAATYGRRWLAGRLALDVQHEVRVDLLTALHRYDGPRQDRLRTGQVVSRSISDLQLVQGLLAMAPLSAASLLIFAFAAVAMLVLSPPLALVSLLTVPVLALVVYRVRPRLHAATWSAQQRAADLAQHVEETVTGVRVVKGFGQESRMVRILEEHGRRLYAHRMRAARIDSRFAPTVSAIPQAGLVIVIALGGTLALHAVIGVGTFLAFATYVTMMASSTRILSSVLVMAQLTRAAAERVYQVIDEAPESVDPPDPQPLPEGPLGLHIRGLTFGFEPGRPVLHDVDITVRPGETVAVIGPAGSGKSTLTLLLPRFHTPEAGRISLFGAGAEQDPETAGIDIARVRAADLRAAIGVVFDEPFLFSDTISANIALGKPDADPEEIRTAARMAAADEFIRALPDGYDTVVGERGLTLSGGQRQRLALARALLADPRILVLDDATSAVDAVTEAAIFDALPAHGRTTLILAHRESTLAHADRVVRLPAPGGRTADRSDDAEVEPGDVVEPGPRASTASDRIEYASAHADGAIFAPGIERPAHDGVDPAGPPRATPVSTSGAIAPPHPGSPAHPGATPDCEDVVAVADSNPEPDAPPEMRAALAKLAPATEQPGLDDRELEQPDPKFRLVRLLRPVRWLLAAVIALLAVDAGISVAFPALTRFALDDGVGQHRGTVLVIAALAGAGLVLLSWVDEALGTRLSARGGERVLYGLRVRSYAHLQRLGLDYYERELSGRIMTRMTTDIDALSTFLQTGLSTALISLVTVVGIVIALLVIDAALAVVVFVALPPLIVATLFFRRVSASAYSASRERVATVNADFQENVAGLRATQAYRHEAEAARRFTDYSDRYRRARLRAQRAIALYFAFVLAWADLAQAAVVYLGAREVAHGTTTAGTLVAFVLYLSLLFGPITQLSQVFDGYQQARVGLRRIETLLHTPSSIAPDPADAVEIEGGLRGEVRFDGVTFRYPDARTPALEDVSLHIPAGSTLALVGETGAGKSTVVKLLARLYDLPRSHPNQDGAAGAAHSGSIRVDEIDIRDYRLAQFRARLGVVPQEAHLFTGDVASNIAFGKPCATSSDIARAAAAVGALEMIESLPRGMAQPIGEGGRGLSAGQRQLIALARAELVDPDLLLLDEATAVLDPANEEKVLVASRSLARGRTTVIVAHRLATAARADRIAVVAHGRIVEFGAHAQLLAERGIYDRLWEAADSDEGIFSTRDESSPMRLGLSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY98</accession>
    <name>A0A231GY98_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41594">
        <property type="protein sequence ID" value="OXR41594"/>
        <property type="gene ID" value="B7C42_06235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15493" checksum="30135F057955AF00" modified="2017-10-25" version="1">MIGLFVDVGHPRGGFVDVLIDEDRPSRHERSEWHAATHRHPVGSEVTAEITDIFATTREYLVTFDGRWSAVFWTGIPPIVGTTAQFIVDRHLDATRRIRLRHRSVRGQVVTIGACSSATDSSGSSEELSVISRAWPSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYH0</accession>
    <name>A0A231GYH0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyl homoserine lactonase AttM</fullName>
            <ecNumber evidence="2">3.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">attM</name>
        <name evidence="2" type="ORF">B7C42_06314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.81" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783102.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41673">
        <property type="protein sequence ID" value="OXR41673"/>
        <property type="gene ID" value="B7C42_06314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102007">
        <property type="term" value="F:acyl-L-homoserine-lactone lactonohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="72"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="31828" checksum="AC6F8CC04D67C5BE" modified="2017-10-25" version="1">MKTFWTTTHPTTPAQLGTPVSATQMEAVADQPGPVEVETVGTDWVANLSGLLNIKDPKAVAAGLKQRKEPIKIYTHVVRHPQHGFFLVDTGVAERFAHDPASVGVGWVLRKFAGVTDMNPEPSTAQVIASQGAPLAGVFMTHLHLDHVSGLPDIPTDVPIYVGPREAEASLFANLVAQGTNNRLLKGRPPLQEFQIPKDPDGTFDGVLDVFGDGTFFAISTPGHTLGHLSYLARTADGPILLTGDTSHTRWGWENDVEPGSFLAERERSRESLHALKALSQRHPDMTVRLGHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ0</accession>
    <name>A0A231GYJ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein YecD</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yecD_2</name>
        <name evidence="2" type="ORF">B7C42_06334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41693">
        <property type="protein sequence ID" value="OXR41693"/>
        <property type="gene ID" value="B7C42_06334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="187" mass="19573" checksum="D48202F63C0682EA" modified="2017-10-25" version="1">MPVTTLDPATALIVIDLQQGIVGRPLAHPVEPVITRAAALAQAFRDRDLPVVLVNVAGAPPGRTDAGAMTMTDLPPDWTALIPEMTPQPGDIQVTKHARSAFAGTGLADRLRAEGVTQVVVVGIATGAGVESTARDAHEQGFHVTLPVDAMTDSDGERHNHSITHIFGRIAETGTTDDVLQTLAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYK7</accession>
    <name>A0A231GYK7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41611">
        <property type="protein sequence ID" value="OXR41611"/>
        <property type="gene ID" value="B7C42_06252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="37439" checksum="B711B9AB42F31316" modified="2017-10-25" version="1">MTRGDVHLCGSVPLPDAEAVFDTAARRLGPWLSRIPDGETGERDNFTVWQLPRMGAHPDLETVPPPSPEYGPSERVRPKPGVDPASIDFGELGYAQAALESWGVFRKLRERGDIDAGVRFQVCLPTPISVVGAFVGDPQDILEQRYEAALLAELGRIAAAIPHTDLAVQWDCPVEFAIFEGVFPSWFGADDETRLSEIVARLVRLGAAVPGNIELGYHLCYGDFGHRHFAEPADTGRMVAVLSGVLAALPRRVDWVHMPVPRSRADRAYFAPLAGLHLPPQTRLYLGLVHATDGRDGALRRIRGAREIVDGFGIATECGFGRRPAEHIPDLLDLHAELAAMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYN6</accession>
    <name>A0A231GYN6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">grsB</name>
        <name evidence="11" type="ORF">B7C42_06341</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41700">
        <property type="protein sequence ID" value="OXR41700"/>
        <property type="gene ID" value="B7C42_06341"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2537"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3611"/>
            <end position="3686"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="4676"/>
            <end position="4752"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="5723"/>
            <end position="5798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1953"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2614"/>
            <end position="2634"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1039"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2572"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="3646"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="4712"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="5758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR41700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="6068" mass="651210" checksum="A7D104847118FB96" modified="2017-10-25" version="1">[encoded data, 6068 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYU2</accession>
    <name>A0A231GYU2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41769">
        <property type="protein sequence ID" value="OXR41769"/>
        <property type="gene ID" value="B7C42_06111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7424" checksum="A36828FCABC77749" modified="2017-10-25" version="1">MTGRAVRGRPVRGSGQATAVLVDEELDDEAELLDELDELLEPAESLDLDSLDFAAGSLADDEPLRLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYX7</accession>
    <name>A0A231GYX7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41817">
        <property type="protein sequence ID" value="OXR41817"/>
        <property type="gene ID" value="B7C42_06159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646860" evidence="2">
        <location>
            <begin position="27"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="243" mass="24332" checksum="32F53D54982CD113" modified="2017-10-25" version="1">MTFMTPALITALGVTAAAVTTGTAHAEPDRAAVHYEIGRRADSALVTTPDGKLKVVADQLILTTRDDRPVAAVPLTFAVDDTAYPITARIDGDTATLTPDRGSGRPTEARRDVVSVRQAAESFTPRDSQALGAFGQRVAIAAGVSAVLGAVIGGGIGCLVGGAVGAAISSPVIVLLAPFVGATVAGCVLGTATLGAVGSMAGLILAGGPITLFSAIQYFSTVLAPCPPELPYCKDPAQPAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZJ1</accession>
    <name>A0A231GZJ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42033">
        <property type="protein sequence ID" value="OXR42033"/>
        <property type="gene ID" value="B7C42_06017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013076431" evidence="1">
        <location>
            <begin position="32"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="484" mass="49625" checksum="0A9ED0DD925AF7BA" modified="2017-10-25" version="1">MRRKGFTEGAITSIAAAAAAILTIGVGTASAAFGPPPPVDPYLGPVGTATMHGDAESSDSTPLPGVGTGAVNAQFRELAAACPTILQGADGMPQALCTTVTDRSPKIFLLDPNSGQPLTSLSLPKGGLLGGIYAYLDNADHLVMVDGDDNLVRVAHTKEGNGWKLAIASSTPLGAAVTGHCGGNGCDSVASLMPDRDGRVWFATANGAVGAVDPKTGAAQSITLPGEHVDNSISTAPEGTAVTTDHATYLFTADASGAPHQVWRQPYDRGPARKPGQLSWGSGASPTFFGPRDGTDYLAITDNAVPQENLLVYDTRTGRPVCSVPAVDGTENSPIGSGNSVFVASTYGYPYPALPDNAGPSEPDKADFTGGMVRIDVNADGSGCTRKWTSDVKSAAVPRLSLADGKIYTVARKNRIAGIDTGSAGAVVDTYHLVVIDAETGTENSSRLIGTSTVHDTLQMVGTIAPGRVQYQGTTTGLFRITPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZM7</accession>
    <name>A0A231GZM7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782828.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42076">
        <property type="protein sequence ID" value="OXR42076"/>
        <property type="gene ID" value="B7C42_05675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="29433" checksum="C24A12A5136FF2A5" modified="2017-10-25" version="1">MTDTVRILTTIGTRNVTREQVRAWESRRATAVLGKLAARLGHLGMNEIMPDRTPQELRTAPLDEQRYALTTLKTGLGHAGIYALLRHELTFSERTSRIGVAASRGRTKHAVTRLEVPDYSAERFATWFNDLTTTNAETDMIHACPDHYLVRGLPDGRQEVVETTGGSPAATRFLIDYTAGDILTIPIDPDYPIQIAGAATLDDGLVIGGVRHQFRDRDGALDALLTVQFPATVPTRLIRQHQWHLAAEFSNWIIAAAPTADTRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H061</accession>
    <name>A0A231H061_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor FabR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabR_4</name>
        <name evidence="6" type="ORF">B7C42_05852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779736.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42253">
        <property type="protein sequence ID" value="OXR42253"/>
        <property type="gene ID" value="B7C42_05852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="27568" checksum="61FF87A4420215CC" modified="2017-10-25" version="1">MSRRTHGKQNKRSLDEEGGRPRAATAQRTQAQRRHESRSAIIEAALELIAGGEAFEALSLRKIATTAGLAPSAFYRYFESLDALGIAIIEESFRRLKKLLASMDPPAPGEADTLLSDLVDVVGEYTRQEYSYIAFVARERIAGSATMRRVIRTEIRVMINQMATVLARTEPVNRWPIKDTKMLATLLVTVLIVSLDSSLDVLSVPARRDDPDALVEVNANTKMQLAYLLDARSAWRPGRREAARKGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0M0</accession>
    <name>A0A231H0M0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">B7C42_05593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42393">
        <property type="protein sequence ID" value="OXR42393"/>
        <property type="gene ID" value="B7C42_05593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="650"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="829"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR42393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1204" mass="130577" checksum="622F8F2D26C29477" modified="2017-10-25" version="1">MPSHRPPLAGLAEVAGADAALSQVRELIGRSSVQLVAPSAIRPFVAATVAAARPLVVVTATGREADDLTVELSEIIGDRVALFPSWETLPHERLSPSADTVGRRLQVLRRLAHPEDPGHPEPLQVVVTTVRSLMQPMAPGLGEIEPIVLRVGAEFDFDELTTRLVEFAYERADMVGKRGEFAVRGGILDIFPPTADHPVRVEFWGDEISELRAFSVADQRSLTEVEVDLVVAQPCRELLLTEELRESAAKVAADNPADAALVEMLEKLAQGIPVEGMEALLPVLRPGELQLLTDVVPTQSHVLLCDPEKIRTRAADLVRTGQEFLEASWTAASFGGAAPLGAHGLDLASSAYRGLDVVRADAESRGLPWWTLSPLAADDPAEVVLPVLSAPAARGSEELVATVFASLRAHVTTGGRAVIVVAGHGTAQRIQERLADADVPAAALEPGAEPVRGLVGVLCGSLHDGIVFDDAKLVVIAESDLTGNRVTAPGEGKKLPARRRNQVDPLALSSGDMVVHDQHGIGRFVEMIERTIGGARREYLVIEYAPSKRGQPGDRLYVPMDSLDQLSRYVGGEMPSLSKLGGSDWANTKRKARKAVREIATELVQLYAARQAAPGHAFASDTPWQQEMEDAFAFTETHDQLTAIAEVKADMERPVPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLAQQHLQTFTERVAGFPVTVKGLSRFTDPAESREVIDGMATGEVDIVVGTHRLLQTGLRWKELGLVIIDEEQRFGVEHKEHIKALRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERHPVLTYVGGYNDKQVAAAVRRELLRDGQVFYVHNRVSSIDKAAKRIRDLVPEARVAVAHGQMNEDTLEKTVQGFWEREFDVLVCTTIIETGLDISNANTLIVERADTLGLSQLHQLRGRVGRSRERGYAYFLYPAEKPLTETAYDRLATISQNSDLGAGMAVAMKDLEIRGAGNVLGAEQSGHVAGVGFDLYVRLVGEAVEAYRAAADGRPITTEEEVKEVRIDLPVDAHIPPDYIASDRLRLEAYRKLAAAQDDSALAAVVEELVDRYGPLPVEVGRLVSVAKLRLLCREYGIQEVGVTGTTLKVSPLQLPDSKQMRLKRLYPSASYRPTTGIVQLPLPRVEDSVGAARVRDVQLLQFVADLLLALDGKPKGMVDLAVRAEVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Q5</accession>
    <name>A0A231H0Q5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetyltransferase YsnE</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ysnE</name>
        <name evidence="2" type="ORF">B7C42_05240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42464">
        <property type="protein sequence ID" value="OXR42464"/>
        <property type="gene ID" value="B7C42_05240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="15927" checksum="946EBC1725112760" modified="2017-10-25" version="1">MPPVTVAADDPARADVRALAARHLAFARAHTPAGAVFALDPDTGADPHLTLVTARRDGMLLGVGAVRDLGAGHGELKSVHTDEAARGHGVGTAIVTHLLALARARGWVRVSLETGVGEAFRPARTLYARCGFVACGAFGDYADTGTSAFMTRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H120</accession>
    <name>A0A231H120_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative succinate-semialdehyde dehydrogenase [NADP(+)] 2</fullName>
            <ecNumber evidence="5">1.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gabD2_6</name>
        <name evidence="5" type="ORF">B7C42_05337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.79" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42560">
        <property type="protein sequence ID" value="OXR42560"/>
        <property type="gene ID" value="B7C42_05337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="31"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="517" mass="54875" checksum="B4F52C2B4768FB81" modified="2017-10-25" version="1">MPVPEAAVFERLRAFASVDDARDHANKTIAETFTGRPLGEVPVGTADDVSAAFTRARAAQADWAKRTPKERAAVLERFRDLIISERDYLMNVIQAETGKARWAAQEEILGMMFAARYFSRVAPKLLAPHSVPGAFPVLNRAQVRTQPKGVVGVIAPWNYPMVLSIGDAIPALLAGNAVVVKPDSQTPFSSLASVELLLRAGLPRDVLQVIPGPGGVVGTAIVDQCDYLMFTGSSATGRELAQQCGKRLIGFSAELGGKNPMIVTRGANLDKVAKAAVRACFSNAGQLCISIERIYVEQSIAAEFSEKFVKAVGAAKLGAAYDFSTDIGSLISPAQLETVTKHVADATSKGAEILAGGNARPDLGPLFFEPTVLSKVTDEMECGRNETFGPLVSIYPVADVEEAIARANDTEYGLNASVWASSASEGQAIAARLRTGTVCVDEGYAPAWGSTGAPMGGMGISGVGRRHGPDGLLKFTEPQTVVVTRGMNLDAPLGIPQSKWQALLMMLARSFRFLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H141</accession>
    <name>A0A231H141_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_18</name>
        <name evidence="5" type="ORF">B7C42_05318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42542">
        <property type="protein sequence ID" value="OXR42542"/>
        <property type="gene ID" value="B7C42_05318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="205" mass="22371" checksum="4272341C661BE7D3" modified="2017-10-25" version="1">MDTCSNRYSQHVPRPLDQARRAELLAGVIAYIGEYGLTELSLRPLADYLGTSSRMLIHYFGTKEQMLIAALETQRPDIAGMFADVPDLPALRRRLIESFSVNITTEWVSSTRVLLQVMGVAAVPGSPFRSYGEDAVHVLVTALTDVLRSFEPTVADPESTATLLVSGVRGLLQDRFVTGDTARVSRAARLLITQSLTPPEPGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H166</accession>
    <name>A0A231H166_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777331.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42541">
        <property type="protein sequence ID" value="OXR42541"/>
        <property type="gene ID" value="B7C42_05317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="16160" checksum="774A652AA2BF3E3B" modified="2017-10-25" version="1">MAFVIDDTVEIDAPAEVVWKVLTDLGSYGEWNPFVAECRSTLEPGDPIEMHVRLGSPKPRKQVEYIRTHTPGTEFSYSMKPVPLGILHSLRSHTVTPLDNGRTRYRSHFELGGLLRPVVTLALGKALQSGFGGMTAAVKERAESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H169</accession>
    <name>A0A231H169_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subtilisin DY</fullName>
            <ecNumber evidence="5">3.4.21.62</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">apr</name>
        <name evidence="5" type="ORF">B7C42_05381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782775.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42604">
        <property type="protein sequence ID" value="OXR42604"/>
        <property type="gene ID" value="B7C42_05381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="128"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="434" mass="44526" checksum="2D4D912B40430157" modified="2017-10-25" version="1">MRALIQLRPSADLIAAVADPAVAVAPADVAGDLPGFDLDHDFAPLSVPDTVSAEQAGAGSVVVRGQIPDGDLDATVARLTGTRGVAGVFADPRIETNLTCGGDPAVGTWHDVQTLLHTGDLAAGGMDGKSVAVAIVDTGINAARVEQARGGPVTVDTARSWNPPGVSGTAGQFPVDHGSMCAFDTLIGAPNATLLDIPVLQSKTRGGSTMDGLLSDALAAYAHLRTVLTDQPEATRTLVISNSWGAFSPDWDFPVGQPGNYSDNPSHPFNVIVGSLESAGADILFAAGNCGRDCPDSRCAYRDRPIGGANSHPSVLSIGGADTKGQRVGYSSQGPGRLSDRKPDICSYTHFLGSTVFGAKEPDTGTSAACPVAAGLVAAIRTVYPASKLAPAQLRDLLRRTATAQPGGFDYDYGFGVVNSAALLAELKNTEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1E9</accession>
    <name>A0A231H1E9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42685">
        <property type="protein sequence ID" value="OXR42685"/>
        <property type="gene ID" value="B7C42_05021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="173" mass="19534" checksum="10A3DD9AC8D8727A" modified="2017-10-25" version="1">MIVRTEHPIVTAVLDRHRDDLGDDLTTYRNHVLRCLNYHRALLDTPLPEAAVLAWAVHDLGIWTAGTFDYLAPSSALAEEYAAEFAISDHQAVRRMVLDHHRVRAVDDPVAESFRIADRIDVSGGLLRGGLPRAEVRAVVAALPYHGFHRFLAESAARWALRHPLRPLPMLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1K5</accession>
    <name>A0A231H1K5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_05070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42733">
        <property type="protein sequence ID" value="OXR42733"/>
        <property type="gene ID" value="B7C42_05070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="4">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="5">
        <location>
            <begin position="205"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="425" mass="44633" checksum="6711D6658A57A094" modified="2017-10-25" version="1">MDSTTAHSISAVERIPITMPIRVPNVHARRAQPTTSCPAAGPRTDPRKTPTANQALASVGGMISTIVWGTGNVGRAAIRAVHAHPELELTGVLVHDPAKVGRDAGRLAGLDHDLGVTASADVDALLARHPRAVVYAASGDIRPDDALRDIVGAIRAGAVVVTPALYALYDPRNAPAEVREPVRAAIAAGGGSLFVSGIDPGWGNDVLPLLVSGLGHRVDTIRCQEIFDYSTYDQPDSVRYLVGMGQPMDYEPPMTAPGVPTMVWGGQIRLMARALGAELDGIRETLDRRALDTTVTTAAMGDFEAGTQGAVRFEVQGMVGGRPRIVIEHVTRIHPGCAPDWPCPPDGAGAHRIIVEGDPRIEVTVEAETEGGNRAAGGNATAVGRLVNAIDWLAAAEPGLYDALDVPLRPAVGRFASDPSERTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1M3</accession>
    <name>A0A231H1M3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42717">
        <property type="protein sequence ID" value="OXR42717"/>
        <property type="gene ID" value="B7C42_05054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="55"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="34982" checksum="0CFDBB461B0E55EE" modified="2017-10-25" version="1">MSTLSTVLDPLRHTAGYARYFLNKSARDRADAQALRELEARPLTLPAGLEIEWLGTAGYRMTYEGVTLLVDPFLTRVPLSTVVRRRTALPDPASIDRFLPALEDVAGIVVGHGHWDHALDAPELARRFGCAVYGSRSVRNLMELHGLGARGVEVEPYRRYELGPFTVTFVPSVHSKIPFGTRIPSPGDTSCESLAALAPMAYGCGQTWGIHIAVAGVEIYHQGSADLVDEAIRHRDVDIFLAGVAGRSVTPDYWRRILTRLRPTTVVPMHYDDFLRPLDAPMGFTVDIALASVPDEIGAVSRAIDVVALPLLSPRAPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1M5</accession>
    <name>A0A231H1M5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-containing monooxygenase EthA</fullName>
            <ecNumber evidence="5">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ethA_1</name>
        <name evidence="5" type="ORF">B7C42_05079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776866.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42742">
        <property type="protein sequence ID" value="OXR42742"/>
        <property type="gene ID" value="B7C42_05079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="490" mass="54544" checksum="BA8E3EE4222ABFF5" modified="2017-10-25" version="1">MTAAGEYVDVVIVGAGLSGIGAGYRVQTELPGKSYAILEAREALGGTWDLFRYPGIRSDSDMFTLGYPFEPWRDAKSIADGPSILRYITETARRHGIDKHIRYGTKVVAAQWSSAESRWTLTLRQGDAERTLSCRFLYSCAGYYNYDEGHAPEFPGVDTFSGTMVHPQFWPEDLDYAGKKVVVVGSGATAVTLVPAMAEQAELVTMLQRSPTWISAVPGRDKQADKIRELLPAGLAHRVIRTKNILFNVGFYQYCRRRPQAARKLLTGLTTRILKDEKLVAEHFTPEYNPWDQRLCAVPDADFFKAMRKGKAEVVTDHIDTFVPEGIRLKSGRVLPADIVISATGLKLLAFGGITLEVDGEPVNLSDRFVWQGTMLTGVPNFAVCIGYTNASWTLRADLTSRLVCKVIAHMDRRGYEAVVPQPQAELTEHPLLDLASGYIQRSIGDFPRQGDRHPWKVRQNYLLDSATTMRTNLDKTLQPVRRTAVLSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1P4</accession>
    <name>A0A231H1P4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bmr3_8</name>
        <name evidence="8" type="ORF">B7C42_05104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42766">
        <property type="protein sequence ID" value="OXR42766"/>
        <property type="gene ID" value="B7C42_05104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="36"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="848"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="899" mass="93476" checksum="39DD8D0DE5B88654" modified="2017-10-25" version="1">MTTSTSEAPPAQPNAPTVAPAADVRPSLSHRQILTILSGLLLGMFLAALDQNIVSVAIVRIANSLHGFDQQAWATTAYLITATISTPLYGKLADIYGRKPFYLLAIGIFVVGSAACTFATSMYELAAFRAFQGLGAGGLMSLAMTIVGDIVPPRERARYQGYFMMVFGTSTVLGPVLGGLFSDYDTLWGIDGWRWVFLVNVPIGVVALAVVAKVLNVPHQRQKLNVDWWGAIALAICVVPLLIVAEQGRTWGWGSGGSVICYAIGAVGLVLFIGVEYLMKDSALIPLRLFKNSTFSVVMIGGFIVGIAMFGAISMVPLYLQVVRGYSPTEAGLLMLPLVLGIMIGSMISGQVVKRTGRYKILPVVGTFLVTVGALLYAQLHFDSAMWQVLAIGALVGLGLGCCMQTLIIAAQNAGPRSDMGVSTASATFFRQVGGTLGVAVFLTILFNLLPHKITDAFGGHLPPGLDAGKLNQLQANTAGIGALPQQIKDPILIGFTNSMHGVFYAAAGVALLACIVMMFMKEIPLQDASAPAPAPKDPVEAAEAEWAENQVWEGAAQALSEPEPVLAAAAAGRHAAANGHESHRIAEVSAMTNTPVVNSHGSGHAIGGQVQRADGRPVAGAALTLIDQRGHQVSRSTGDSGGRYSIEPPGAGSYVLIVSANGHQPAAVNVTADGRTQRLDLTLQGSGELSGMVRTAGAGQPLAGATVTLTDLRGEVVGAAVTDASGNYLCHGVVSGTYTLVAVAEHMRPSATALVVPDSGLLHHDIELSPMAVLTGTVLADGGAVLDAEVTVLDRSGTPIGTTRTDENGQYVLTDLSEGEYTVVARGYPPVTSRVTVGGGEVEHDVRLGYDDGDEGVRPAAEPTGVAGTNGVATNGERNGVRHNGVEPSGVDQNTELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Q9</accession>
    <name>A0A231H1Q9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42778">
        <property type="protein sequence ID" value="OXR42778"/>
        <property type="gene ID" value="B7C42_05116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="232"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="475" mass="49128" checksum="2906FA5BFFF0B153" modified="2017-10-25" version="1">MIYSAHTQQPPSGAPSRPPRRLPAFLLPATICVLTGAVACLAVLRFAPDTARVAFAIAAGAAGLLLAVTSGCAAHYRDQAIHYREANDRAERAAATYVAESEARLAAAHDTASAAGREAHGSENRRVAAMAAFAGAAGSMQAMTTSMLAELREMEHRHADPSVLADLLTLDHRTAQAGRLADSIAVLSGARSGRRWAKPIAMESILRGAMGRVAGYRRVRLRAVAEIAIAGHAAEGVMHALAELIDNACNFSPPTTEVHVYAAEVPAGVVVTIEDSGLVMSETALRRAEQAVSGTVAGRGSDTDLSSLTGTRLGLAVVGNLARKHALTVSYRPSAIGGTAVVVVVPRDLTTRLDRSPGSTATIELPPAARPVTPAALPASPFGPPLTGDTEPAASTPNTEQPAAQSVPPLERSAEPLPKRRRGSTLAAVHPDGLRPTAAENSAYPPARPSALGAFQRAVSAPDSPSPSIALENDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H273</accession>
    <name>A0A231H273_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42944">
        <property type="protein sequence ID" value="OXR42944"/>
        <property type="gene ID" value="B7C42_04830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="29775" checksum="62080E1433018613" modified="2017-10-25" version="1">MSPSRAIDFKQCPLKYRLRAIDRIPETPGRDAVRGTVVHAVLESLYGLPSGERVPERAAALVEPAWQRLLADRPEIEVVLEQGGLPPFLDEVSRLVRGYYHLENPTGFDPESCESLVEVRLADGSPLRGYVDRIDIAPDGRLRVVDYKTGRTPAPDAEQKALFQLKFYALIMYRTRGVAPAELRLLYLRDGQILTYAPDADELVRFERILSALWAAITTAGRDGDFPPRPGWSCKFCEYRSLCPAYGGTPPPYPGWPDDAAATVPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2A2</accession>
    <name>A0A231H2A2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778419.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42973">
        <property type="protein sequence ID" value="OXR42973"/>
        <property type="gene ID" value="B7C42_04859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12653" checksum="7434DEF59579D89A" modified="2017-10-25" version="1">MGTWNALSSVITVLSGCGVVLLAVGCFWPGDDPPRTRHVDRWDGANPGPPIARLTDWSCAPPAGPFTTAEAHHWMQIHRDHDCPRKREAFAALVAAGRIRPDSTRRNTVRSEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2N8</accession>
    <name>A0A231H2N8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777905.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43120">
        <property type="protein sequence ID" value="OXR43120"/>
        <property type="gene ID" value="B7C42_05006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="45491" checksum="7B7CF32CB15EAA1E" modified="2017-10-25" version="1">MPASTLTDRRCEDCSHPIDDNTTVTIVEGDHLCRACADRLDTCDDCATPTRERRSTVRGTDVCTDCSIGWRRCRDCDRFDSDLVRVIGHGEVCDDCADSYLVCDDCGSRADGLSETESGADVCGRCADADYHRCGGCDILIRCWEDYCDACANQHPDHRGVHSYSYKPEPDFHGTGPLYLGLELEIKTPREVFDEAVELAIDQLGDIGYLKYDGSIQPCGYELVTHPMSYEFARQRFPWSLPNRLRMLGAYTDTSVGIHVHVSRAGFSSPAHTYRWLKFVYRNESHVKRLARRDSEQWAVFDPGARANAAAHAKGETRCEFRYQAINVCPEDTFELRVFASSLDTREVQAALAFADASVEYTRTLSAADIARRRGWEWAAFTAWLAARPEYRCLTDELEALACAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2U5</accession>
    <name>A0A231H2U5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-phenylpropionate/cinnamic acid dioxygenase subunit alpha</fullName>
            <ecNumber evidence="7">1.14.12.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hcaE_2</name>
        <name evidence="7" type="ORF">B7C42_04597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.19" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43175">
        <property type="protein sequence ID" value="OXR43175"/>
        <property type="gene ID" value="B7C42_04597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008695">
        <property type="term" value="F:3-phenylpropionate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="445" mass="49838" checksum="5D220D682080F1FA" modified="2017-10-25" version="1">MTTHVEHRIEQPSTAGVPFAITDPAKVPAGRYFSPEFAQLEKEKLWPHVWQMACRADEIPRPGDFTEYKINDQSIMVVRQRDDTVKAYFNACRHRATALASDSGTFHGGQIVCPYHGWRWNLDGSNSYVYAERGFAPHCLDPESLRLVECQVGELFGLVWINMDPAAPPLHEAMAGIAEALAPIAFERMRVRWWRHLILPGNWKVAQEAFMEAYHVMQAHPSLSMGASDEDFNLDAFGGTFETFDGGHAHMLPVPGEIPVEGMSAAEYFVQYNTALYLGTDAYATEREMFIQQGLLERDIDPDQFPSAFFGALYDYAKGAGVDLPAPPTKTSGYGHIFPNITVLPAYGNSIMYRVRPNGDDPESCVFEVWALQIPAAGEESADRPELEGPIPVEDWPQILKEDFHNIIAQQKGLKTRGLDGLTLSEPYEAMIVNSHRTIDQYLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H305</accession>
    <name>A0A231H305_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD/NADP-dependent betaine aldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">betB_2</name>
        <name evidence="6" type="ORF">B7C42_04663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009645.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43241">
        <property type="protein sequence ID" value="OXR43241"/>
        <property type="gene ID" value="B7C42_04663"/>
    </dbReference>
    <dbReference type="GeneID" id="66723453"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008802">
        <property type="term" value="F:betaine-aldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="26"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="496" mass="51979" checksum="C24446674D9F4B67" modified="2017-10-25" version="1">MTSTGTDKISSLPLVIGGVEGGAESGRSYESLDPYTGSPWIRVPDCGPEDVDRAVRAARAALEGPWGALSGAARGKLLWRLADLIEREADRLAELEVRDGGKLLREMSGQMRSLPDYYRFYAGLADKVQGEVIPTDKPDYFVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVIKPSDYTPASTLAFARLFDEAGFPPGVVNVVTGWGPETGAALAAHPGVDKIAFTGSTATGVKVGQAAIANMTRVSLELGGKSAQLVFPDADLDAAANGIVAGIFAATGQTCLAGSRLLVHESVAAELVGKLVARAERIVLGDPRDPATEMGPVSNEPQYRKVLSYFDSARAEGATVASGGTPVPELGGYFVRPTILTDVTPRMSVVAEEIFGPVLAVATFADEAEAVAAANGTRFGLAGSVWTKDVHRAHRVAAALRAGTVWVNAYRAVAPSVPFGGIGESGIGRENGIDAVKDFTETKAVWVELSGRTRDPFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H324</accession>
    <name>A0A231H324_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adhB</name>
        <name evidence="5" type="ORF">B7C42_04640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43218">
        <property type="protein sequence ID" value="OXR43218"/>
        <property type="gene ID" value="B7C42_04640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023921">
        <property type="entry name" value="ADH_Zn_actinomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03989">
        <property type="entry name" value="Rxyl_3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="17"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="379" mass="40543" checksum="833790ADB7BF258F" modified="2017-10-25" version="1">MMETTAAVLWERNTPWSVETIELDPPKAEEVLVELHASGMCHSDEHIVTGDMPFHLPCIGGHEGAGVVKQVGSSVSWLREGDHVVFGFIPSCGRCPSCATGHQSLCDLGAKIYSGRQIFDDTARHHARGRDLALACGVGSFAHHTVVHEASCIKIEPHHPLDRACLLGCGFVTGWGSAVYAADIRPGHNVVVAGVGGIGAAAVQGARLSGARTIVAIDPSESKREAAMRMGATHVAASWEEAPEVVREATWHRGADRFICTMGVGEGRLIAQALAMVAKRGELIVTNIHPMAENEVSVNMMDLTLTEKRIIGSLYGSANPRADIPKILELWSNGQVDLDAVVSRAYPLEKINDGYEDMRAGRNLRGVLRYPAADAVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H376</accession>
    <name>A0A231H376_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carnitinyl-CoA dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">caiD_6</name>
        <name evidence="6" type="ORF">B7C42_04743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.149" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43321">
        <property type="protein sequence ID" value="OXR43321"/>
        <property type="gene ID" value="B7C42_04743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="27525" checksum="0D84040557646BAA" modified="2017-10-25" version="1">MTAATETGALVERKGNVLLITINRPEARNAVNAAVSEAVGGALVEAENDPEIRVVVITGAGDKSFCAGADLKAISRGEGLFAPGNEHWGFAGFVRHVISKPTIAAVNGTALGGGTELALAADLIVAAEGASFGLPEVKRGLIAGAGGVFRLPAQIPQRLAMEMILTGDPIPAATARKYGLINQVVPDGTVVEAALALAERIAVNAPLSVQASKRIALGIQANDRPAENDRWSHSEVEWQSLMSSEDAKEGPLAFAEKRAPVWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M5</accession>
    <name>A0A231H3M5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pgsA</name>
        <name evidence="12" type="ORF">B7C42_04325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43458">
        <property type="protein sequence ID" value="OXR43458"/>
        <property type="gene ID" value="B7C42_04325"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR43458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="23746" checksum="88BFF4045A7528BC" modified="2017-10-25" version="1">MLSFFGRETFAKATAPLGRALVSTGLTPDAMTLIGTTASIVAAVTLFPTDHLFWGTMVIWLFVMFDMLDGAMARARGGGTKYGAVLDATCDRVADGAIFGALAWWAVYHEHSKHLFVATLVVLVTSQVISYAKARAEASGLSADGGIIERPDRLVIVLVGAGFTGIGGYFDIEWLTYAVYVAMYILAVLSIVTVFQRVLAVRNSAGARDVIAPVTKAESDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Q9</accession>
    <name>A0A231H3Q9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">pyrR</name>
        <name evidence="7" type="ORF">B7C42_04421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43553">
        <property type="protein sequence ID" value="OXR43553"/>
        <property type="gene ID" value="B7C42_04421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="6">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="24211" checksum="42086F8E9A57E9E6" modified="2017-10-25" version="1">MAVPEERGGRVAPEERAARSSAAEYSQRHDPEWVRAGRELLSAPDVGRTIARMAHQIIEKTALDSSDPEAPRVVLIGIPTRGTTLAARLTDRIEEFSGVRPALGSLDITLYRDDLRNRPHRPLERTSVPEGGIDDALVVLVDDVLFSGRSVRSALDGLRDLGRPRAVQLAVLVDRGHRELPIRADYVGKNVPTSRSEDVSVLLSEHDGHDGVYLHQGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H436</accession>
    <name>A0A231H436_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase NlhH</fullName>
            <ecNumber evidence="2">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nlhH_3</name>
        <name evidence="2" type="ORF">B7C42_04537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43669">
        <property type="protein sequence ID" value="OXR43669"/>
        <property type="gene ID" value="B7C42_04537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="117"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="368" mass="39426" checksum="608265E37DB4BFF3" modified="2017-10-25" version="1">MPKRPQPRAERAARSAVRWITLLPPSLKRLITGKPVCIDGQQLDLDIQLGARLLSSGGNFDSTPIRRLRSQSATAARIHGDPLPLENIRDITIPGPAGEIPARLYRPTEIEGPTAALVYYHGGGWTLGDLDAADAVARFLAHHAALTVISIDYRLAPEHPFPAGLQDAIAAFNHVAAHPNRYGIEPEAIGVGGESAGGNLAAVVTQQSAFAARTNPVPIPAFQLLLMPVTDLSTERPSHQLFSSGPFLTNAHLKWFRAQYLTDPAQQHDPRVSPLLSDDLRGLPPAYIATAGFDILRDEGEAYAHKLATVGVPVVLRRHSSMAHGMIGATSTLQPARDALHEAAAAIRVILAFRTLTTTATAKPASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H457</accession>
    <name>A0A231H457_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cardiolipin synthase A</fullName>
            <ecNumber evidence="9">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">clsA</name>
        <name evidence="9" type="ORF">B7C42_03924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043319.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43689">
        <property type="protein sequence ID" value="OXR43689"/>
        <property type="gene ID" value="B7C42_03924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="8">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="15955" checksum="34E8724E1FBD5392" modified="2017-10-25" version="1">MDTFWDYVWYTILVFAFVAYLIILFQILTDLFRDHTVSGIAKAAWVICLVIIPYLTALVYLVVRGKGMAERAQHAQAEAKQAADDYIRQVAGKSPAEQIADAKALYDSGTIDETEFAQLKARALGHNGSGTGNAGTGGADRGNLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4A6</accession>
    <name>A0A231H4A6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">zwf2</name>
        <name evidence="5" type="synonym">zwf</name>
        <name evidence="10" type="ORF">B7C42_04490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778905.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43622">
        <property type="protein sequence ID" value="OXR43622"/>
        <property type="gene ID" value="B7C42_04490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="32"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="223"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="520" mass="58076" checksum="0CDC117B2F7F5D01" modified="2017-10-25" version="1">MAGQKKTAAPGNPLREERDKRLPRIAGPCSMVIFGVTGDLSRKKLMPAIYDLANRGLLPPGFALVGFARRDYADEDFAQVVLQAVKEHARTPFRQEVWDQLAEGIRFVQGTFDDDAAFGTLAQTLKKLDAERGTGGNHAFYLSIPPNAFPVVLEQLSRTGLAKASDAAPGKPQSWRRVVIEKPFGHDLESAQELNALVNRVFPEETVFRIDHYLGKETVQNLLALRFANELFEPIWNANFVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEDPVNFQPRQLQIEKIKVLSATKLVEPLEETTARGQYAAGWQGSERVVGLLEEEGFDPHSRTETYAAITLNVDTRRWAGVPFYLRTGKRLGRRVTEIAVMFKRAPHLPFDQTMTEELGQNALVIRVQPDEGITMRFGSKVPGSSMEVRDVNMDFSYGESFTESSPEAYERLILDVLLGEPSLFPVNEEVELAWRILDPVLDHWAEGGKPESYESGTWGPASADEMLARTGREWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H527</accession>
    <name>A0A231H527_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43937">
        <property type="protein sequence ID" value="OXR43937"/>
        <property type="gene ID" value="B7C42_04176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="31" mass="2883" checksum="0F63C322CB501E88" modified="2017-10-25" version="1">MDTGSSGLGSIFTALANLLSTGSAVSVTPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H597</accession>
    <name>A0A231H597_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_17</name>
        <name evidence="1" type="ORF">B7C42_03635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44079">
        <property type="protein sequence ID" value="OXR44079"/>
        <property type="gene ID" value="B7C42_03635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="27869" checksum="D4C60FA8FF074261" modified="2017-10-25" version="1">MSAGTGLLADKVVVISGVGPGLGRALCVQAAAAGAKVVLAARTESRLREVADEIDGAGGTSLIVPTDITDDAAVANLVDRTVETFGRVDALVNNAFAMPSMKSLARTDFQQISDSLELTVLGTLRATQAFTDELAKTRGAVVMINSSVLRHSEPRYGSYKVAKSALLAMSQTLATELGAKGIRVNSVAPGYIWADQLKWYFGEVAKKYGITVDQVYEQTASRSDLKRLPEPDEIAKAVVFLASDWASAITGQTLDVNCGEYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6F0</accession>
    <name>A0A231H6F0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc import ATP-binding protein ZnuC</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">znuC</name>
        <name evidence="6" type="ORF">B7C42_03240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44451">
        <property type="protein sequence ID" value="OXR44451"/>
        <property type="gene ID" value="B7C42_03240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="31031" checksum="D8ABC6C34967E3FC" modified="2017-10-25" version="1">MTGRTRTEAPEHAPAQASHSTAPTVSLRGASLAFGPRTLWQGLDLDIAPGEFVAVLGPNGSGKTSLLRMLLGQLAPSAGTVEVSGAPARLGNPRIGYVPQQKTIDAGVQLRGVDLVGLGVDGHRWGLGWRGRAERRRRVADAVAQVGAEHFANAPLESLSGGEQQRLRVAQALAGDPRVLLCDEPLLSLDLANQRLVSELIDRRRRTHDTAVLFVTHEINPILPLVDRVLYLVEGKFRIGTPDEVMTSEVLSELYGTEVDVLRVRGRLVVVGTGDEIDALGTHHTEGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Q6</accession>
    <name>A0A231H6Q6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylesterase</fullName>
            <ecNumber evidence="2">3.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44535">
        <property type="protein sequence ID" value="OXR44535"/>
        <property type="gene ID" value="B7C42_03324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="28121" checksum="DBC9A4C75C9D77E2" modified="2017-10-25" version="1">MPYLTVDDVQLYYEDQGTGQPLLFLHGWGTSGRVWGAQQAALVTDFRVVTVDWRGCGRSDRPVAGNNLAGVLADLVELIRQLGLPRPIVIGSSVGATFATELALARPDLLGGVVAVDGPAYWPGQGMPLAEIIGEMRDHRAEFVARWVPNWYAPGTSPALVDWTVRQILDSGVYIDELFHLFATYDPRPRLPQLRTPIHYLHGELDAEIPVAVARACAALTPGARVGVIAGAGHMPQQERAAEFTAALRAAIANLTLQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H739</accession>
    <name>A0A231H739_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44567">
        <property type="protein sequence ID" value="OXR44567"/>
        <property type="gene ID" value="B7C42_03357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="45"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="21049" checksum="904ABAAB418A6B74" modified="2017-10-25" version="1">MVAASNPPGAAVRAVVSRVLGAVRMVRRRRRNRRLGLPDMDPYTIFADIVAGRAPSSKVYEDDDVLAFMDIRPMTPGHLLVIPKVPARSLAELDPVIGGKLFQVAQRLAAALRESEVRCDGVNLFLADGVTAGQEVFHVHLHVIPRTPGDGFGLRNRATTPPRADLDYLAASIRGAAGRAQPNAASGQDGKWWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H755</accession>
    <name>A0A231H755_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44689">
        <property type="protein sequence ID" value="OXR44689"/>
        <property type="gene ID" value="B7C42_03483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="21661" checksum="C0042A87A8F050A0" modified="2017-10-25" version="1">MDSGVFDSTAQVDTRNAKPTSAKIVVAGGFGVGKTTLVGAVSEIVPLRTEALVTNASVGVDSLAAVPTKATTTVAMDFGRISLADDLVLYLFGTPGQYRFWFMWDDLIRGAIGAVVLIDTRRLEDSFAAVDYFEARGLPFLVAINEFDDAPRYPLEDIRQALAVPADVPIMSIDARRREPVKQALVSVTEYALRKVVQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H779</accession>
    <name>A0A231H779_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADP-dependent oxidoreductase YfmJ</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfmJ</name>
        <name evidence="2" type="ORF">B7C42_02738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44784">
        <property type="protein sequence ID" value="OXR44784"/>
        <property type="gene ID" value="B7C42_02738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="35101" checksum="A56F507AB6406B59" modified="2017-10-25" version="1">MTSTPATTRSIHLAARPGGFPELTDFRTVDHPMPAAAVGQVLIRNLFMSIDPGSLMQIGAYPGIPLPPFAIGEALSGDAIGEVIESGDPAVPEGALVLHRLGWREHALADARTVRVVDPDAYSSPSGYLGFGLVAYVGLTVVAGLRTGDTVFVSSAAGATGSLAGQIARLLGAGRVVGSVGSARKAAHIVDDLGYDAAVDYHDEPLVDRLRAAAPDGVDVYFDTVGGAQLRAAIEVMNVGGRIALCGALARQSAGGEPDAGPGDLLAVIGKRLTLRGFTTLDHLDLAPEFGRKLREWTAAGDIVRTETVVDGLENAPRALLDTVRGRYTGKVVVRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7W3</accession>
    <name>A0A231H7W3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_03060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780996.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45103">
        <property type="protein sequence ID" value="OXR45103"/>
        <property type="gene ID" value="B7C42_03060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="24497" checksum="D74D4E1F00B25109" modified="2017-10-25" version="1">MSTWEMLLRLATGVGLGAVIGFERQYRARMAGLRTNALVSAGAALFVLLSAHGFHGGAADPTRVAAQIVSGIGFLGAGVIIRDGLNVRGLNTAATLWCAAAVGALSGAGMYGTAAAGTVAVVIVNIALRAAGRRVDRQPESGHEQPAQYAFTAVTDDAHEAHVRALLVQALTRTDFRLVSVASANAEDAGRVEVRADLVGDQRDDRQMESAVSRLSLEPSVTSVGWRTVEPVAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7X1</accession>
    <name>A0A231H7X1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fdx</name>
        <name evidence="1" type="ORF">B7C42_02928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515738.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44971">
        <property type="protein sequence ID" value="OXR44971"/>
        <property type="gene ID" value="B7C42_02928"/>
    </dbReference>
    <dbReference type="GeneID" id="66722072"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="7357" checksum="D710D93D491471E8" modified="2017-10-25" version="1">MRIEVDLDLCQGHAMCQAEAPDYFDVPKHGKVEIVRPEVDEADRADVENAVRYCPTQALSIVRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Z0</accession>
    <name>A0A231H7Z0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Steroid C26-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.13.141</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.141" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784246.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44969">
        <property type="protein sequence ID" value="OXR44969"/>
        <property type="gene ID" value="B7C42_02926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="45515" checksum="5CD0D346B925BC96" modified="2017-10-25" version="1">MAAPSIPAGFDFTDPGLWAERSPVAEFAELRRTAPVWWNAQNAEQAYPFEDAGYWVVSRHEDIKEISRRSDVFSSEKKGSIIRLPGFATPEQLSVTSALLVNMDPPKHTKIRRIISKGFTPRAVESLRVALTERAERIVRAAKESGGGDFVEQVACELPLQAIAELLGVPQDDRHKLFDWSNQMLNYDDPEYGDSAVASAEILGYAWNMAETRRTEPSDDIVSQLVSADIDGEALGSDEFGFFVILLAVAGNETTRNAITHGMKAFVDHPEQWELYRQQRPRTAVDEIVRWATPVTAFQRTATEDVELGGQLIKAGERVGLFYSSANFDEAAFDKPFDFDVLRDPNPHLAFGGTGAHFCVGANLARLEIDLMFNAIADVMPDLRQIADPQRLRSGWINGIKHWQVEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Z1</accession>
    <name>A0A231H7Z1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lactate utilization protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lutB_1</name>
        <name evidence="9" type="ORF">B7C42_02948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44991">
        <property type="protein sequence ID" value="OXR44991"/>
        <property type="gene ID" value="B7C42_02948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00273">
        <property type="entry name" value="TIGR00273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="493" mass="53288" checksum="88111FCC262FA4BD" modified="2017-10-25" version="1">MTESFVGWPPFPQAARAATADDQLRANVRRATHTIRAKRDALVAERPDWQELRTAAAAVKDDVLRRLDIYLERLADAVEGAGGVVHWATDAAEANAVVTALVRATGEKEIVKAKSMLSEEIGLDEALAAAGIDTRETDLAEIILQLGDDLPSHIVVPSMHLNRSQIRDIFRREMGKHGRPAPDDLTDDPQALADASRLHLREKFLRAKVGITGANFLVAESGTVVMVESEGNGRMCLTLPETLITVAGIEKVIPSWRDLEIYLELLARSATGERMSPYVSTWTGVTAQDGPSAFHLVLVDNGRTRALRDELGREALRCIRCGACMNICPVYERTGGQAYGSVYPGPIGAILNPLLKGADDPQTASLPYASALCGACDDVCPVRIDITGNLLALRHRVAEGEAAVKHRVERAAFDAMAGFMSHPALWGAAVRSAARIGVAVPKRHLPGPLGGWTDSRRVPDIPAESFRRWWARTEGGRHDDGPPHGSADDGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H853</accession>
    <name>A0A231H853_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782375.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45193">
        <property type="protein sequence ID" value="OXR45193"/>
        <property type="gene ID" value="B7C42_02318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="1">
        <location>
            <begin position="117"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="24591" checksum="5A263FF9F43E54C5" modified="2017-10-25" version="1">MKLMYALWGPDLADTLHAPQFHRRLAAAGATELQVNIADADVAAAQLRVSTYDEPVAAIVGVWSEGQNGPITDVLSGVAERINGWIVDEREPLTTARPPDGTRYEALANIALLRIPQELTRAEWLRNWQDRHTTVAIETQATFGYVQNTVVAAVTPGPRVDALVEELFPMDAMTDQHAFWGSGGDDAELQRRAGRMMASVATFGADRDLDVIPTSRYRYDLTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8E1</accession>
    <name>A0A231H8E1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45017">
        <property type="protein sequence ID" value="OXR45017"/>
        <property type="gene ID" value="B7C42_02974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="36974" checksum="169718051CCBABEA" modified="2017-10-25" version="1">MPTPTGPPIALPPEVVETVSTVFGARGRTWLAELPERVETLCALWQLTPLGSAFAGGTHSCAVPVRRADDSVAVLKIPVVDEENVGEAAGLYCYDGDGAVRLYDYDPGSGALLLEWARPGTPLLTQPGFPSLEGLPEHADKVDRACRLYRRLRRPPVPLPDGYPDIPAVSAVIADWTVRFEQPKPEVVHALPSTLLDAATARCAELSRPQGPLVVVNRDTHLGNIVAAEREPWLLIDPKPYLGEAAFDIGFLIMIRIQRLPTAEHAKRMVTATAAATGVDPGRAWGWAFLRAMEEISWAVDDHAPEDLRLHLAVATALHAVAASFEVNRVPANPPSPKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Y5</accession>
    <name>A0A231H8Y5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crt_4</name>
        <name evidence="1" type="ORF">B7C42_02416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776726.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45291">
        <property type="protein sequence ID" value="OXR45291"/>
        <property type="gene ID" value="B7C42_02416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="25087" checksum="9BBCB1E24FA4CB3B" modified="2017-10-25" version="1">MPYLDRDGDVFVLYLGNEGQTDSENRFHPDWIDAIHAKLDEVEAAEGPAALVTVATGKYFSNGLDTDWLFGNMDKMHWYLDRVHTVFSRLLAFGMPTVAALNGHAFGAGAMLATSHDFRVMRSDRGYWCLPEVHLGMPFTVAMNALVTERLSNQVALEAMTTGRRYGAADAIAAGIVDEAAEADGVLAAAVARAAALTGNRKPNLPVIKRALHGRALAGLNTPTTPENLAFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H936</accession>
    <name>A0A231H936_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB</fullName>
            <ecNumber evidence="2">3.5.1.110</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rutB_1</name>
        <name evidence="2" type="ORF">B7C42_02371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.110" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45246">
        <property type="protein sequence ID" value="OXR45246"/>
        <property type="gene ID" value="B7C42_02371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="22933" checksum="B90D6CDB62BD69EC" modified="2017-10-25" version="1">MQHAFGLDIPRTVADACDPARAAVLIYDMQVGIVGQIAAGQQIVDACVRLRDLARENGFRVFYTRHMSLPPAAAGVSQLRTAMAWQRVDDPGRVRSMFPQGSPQYQLVPELTPGPDEVVFDKIAMSAFAGTPLDIALRDLRLDTVVIAGIALEVGIEPTVRHGIDLGYLPIMVTDACGAGHPDAAERSYAAMAFAGGSLTTDLAGLEQEMTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9A0</accession>
    <name>A0A231H9A0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ESX-5 secretion system protein EccD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eccD5_1</name>
        <name evidence="6" type="ORF">B7C42_02560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776569.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45435">
        <property type="protein sequence ID" value="OXR45435"/>
        <property type="gene ID" value="B7C42_02560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="5">
        <location>
            <begin position="118"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="488" mass="50878" checksum="95107A9802274BAE" modified="2017-10-25" version="1">MTHARLDHIEEDSSRGIVRAPDLARVTILAKHTQVDMAIPVDVPVALVIPSVVDMVAQHSRTNDFDNSGEQFQPAEWVLARIGQPPFSNSLSLGEQGVRDGELLMLESADHVAPSPLFDDIMYNVAIADADHFRSWSPRVARITGSIIAILTMLAGCTGLLAAPDAMAGWITGSIAAVLTILLVVAGTVMSRMYGDTASALVLGGCALPSAFAAGMLIVPDHYGWANLLLGSVLVGATALLAWRVSGVGLTLFIGAATLSVFAIPAALVGLLTSQPVKAIGAVAAALALGALSLAPRVSMLLAKLPLPPVPSPGTPIDPTEDDPDDHRALPTMDVLRTKSERARMYLAGLVGATTLVTVIGALASTDPSADSPYWPGIALALVCAVVLMFRSRTYVSAELAVVLLAGGAAILLIMTVGAAFVVEQPLAVFGAAMVMLIAALILGTIVPNQSATPPMRRAVELLEYGFVAAVLPLVFWVAELYTLVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9B6</accession>
    <name>A0A231H9B6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">B7C42_02669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45544">
        <property type="protein sequence ID" value="OXR45544"/>
        <property type="gene ID" value="B7C42_02669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="16167" checksum="F7D771AA849C7F11" modified="2017-10-25" version="1">MIVVADTSGLLALFNRSDPEHFAVRRAADSASTLVTSQLALTEIHHVASVRGDRKIADRIVALLADRIESGRLVLGDVGADRLRTAVRVRAAYESLNLDLVDAVSVVLAADFDTDAILTLDRRDFRVLRPLNRFRAFRLFPDDLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA53</accession>
    <name>A0A231HA53_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain type dehydrogenase/reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783446.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45834">
        <property type="protein sequence ID" value="OXR45834"/>
        <property type="gene ID" value="B7C42_02126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="31237" checksum="0810098CFD242F83" modified="2017-10-25" version="1">MGRVEGKVALVTGAARGQGRSHAVKLASEGADIIAVDICRDIETIGYAMARPEDLEETERLVEKTGRRIVAVQADVRDIAALRDAVKRGVDELGHLDVVVAQAGIAGMKGEPQWQAWTDVIDTNLIGVINTVHAALPYLDTGASIIATGSTAALMDVAKVDQPGKDPGGIAYMVAKRGLSMYMHELATHIAARNIRANVIHPTNCNTDMLRSEPMYRSFRPDLEKPTLQDAQPAFHVQQAMPVPWIEPEDTSNMVLFLASDESRYVTGMQMRVDAGGYLKWYDYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAE0</accession>
    <name>A0A231HAE0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783416.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45811">
        <property type="protein sequence ID" value="OXR45811"/>
        <property type="gene ID" value="B7C42_02103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="16779" checksum="8A41A018FC84EA5A" modified="2017-10-25" version="1">MRATDQFHIGIVAADMAATTAALSRVLGYEWGIETGGPLTVASPSGEQAVDIRCVYSTTVPRVEVIRAVAGTLWEPVSGSGIHHLGYWSDDVAADIAELEDAGYVVEAVRPGPGGVPLFAFLNGPTGFRIELLSRAAESALARCWAPGNQRRDEGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAK6</accession>
    <name>A0A231HAK6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="6">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crt_2</name>
        <name evidence="6" type="ORF">B7C42_02157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45865">
        <property type="protein sequence ID" value="OXR45865"/>
        <property type="gene ID" value="B7C42_02157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="25669" checksum="6650FD16ECA46A37" modified="2017-10-25" version="1">MVDLEVDGGIAVLTINRPQARNAIAPETMDQLDAAIDAAAGARVLVVRGAGERAFVSGGDLKQLAAIRTEDGAAQMAWRMRGICDRLAAFPAPVVAALNGHALGGGAEFAVAADIRIAADDITIGFNQVALAIMPAWGGAERLTRLVGRSRALLLAGTGTVLTAAEAQRYGLVDSVVSRADFEQEWRSLATALAHPASAPIKRIVSGATPEEAVEAFARLWVSDEHWVAADRVLNRGSRGGSTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAV7</accession>
    <name>A0A231HAV7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium, potassium, lithium and rubidium/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaK_1</name>
        <name evidence="8" type="ORF">B7C42_02281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45988">
        <property type="protein sequence ID" value="OXR45988"/>
        <property type="gene ID" value="B7C42_02281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="546"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="613" mass="64907" checksum="F4611AD55FFC65CE" modified="2017-10-25" version="1">MLAVAVALAALARRVGMAEPLLLTVAGVVASYLPFVPQIDIDPEWVLLGLLPPLLYTASISTSLLEFKPKKVSITLLSVGLVLATTFAVAAVVWRLLPVPFAAAVALGAIVAPPDAVAAIAVARRVGMPRRIVTLLEGESLFNDATALVALRTAIAAMAGSFSVWQAGGDFVYAAAGGAVIGIAAAVVLVLVRRRITDPVLDTGVSLLAPFAAYLPAEAAHASGVIAVVVCGLILGQGAPVWQSAASRVAERTNWRTIQFLLESAVFLLIGLQVRHIVDDAWNSGLDHATIVFTAFAVLVTVIVVRPIWVFPATYFSWFVESRPRGKPKPTWTGPAVVSWAGMRGVVTLAAATLLPGDTPQLATLKLLALVVVGGTLLLQGISLPALVRVLQLRGPSRAEDALQEAALLQQATTAGLEALDEAVAPETPPEVVASLRDRVARRSHAAWEQLGRAESVRVTPSGEYRRLRLVMLHAEREAVLRARDGGGIDHEVLEQVMTAIDLEESTIDRISAADDDEAAAPLAAPVSGGCEHLVAAPHTHTPDHPDCCSECVAEGLTWVHLRMCLTCGHIACCDSSVGNHATKHFHASTHPVMRSVEPGEKWRWCYVDEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAY5</accession>
    <name>A0A231HAY5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F420H(2)-dependent quinone reductase</fullName>
            <ecNumber evidence="3">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46093">
        <property type="protein sequence ID" value="OXR46093"/>
        <property type="gene ID" value="B7C42_01057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18666" checksum="D310B1E655D44FC1" modified="2017-10-25" version="1">MTAQFPDRQWGSRTGLLGRTASAFAATKFGSLVVRTLTPLDRKLLQRTGARYTVLGPIGAPIVLLTTVGRTSGQPRTSPLLYVHDGDTLYVIGSNFGQARHPAWTANLLAHPEATITLAGQSIPVRAQLVEDPVRKQRIFDRFVETTEAYAAYRSRTTRDLRIFALTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA2</accession>
    <name>A0A231HBA2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781402.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46115">
        <property type="protein sequence ID" value="OXR46115"/>
        <property type="gene ID" value="B7C42_01080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="38734" checksum="92534441B33BF395" modified="2017-10-25" version="1">MRNGWVRLRRSALPIFQCAVGAALSWFVAHRLVGHPQPFFAPMAAVISIGVSFGARLRRSVELVGGVAVGIGIGDFFIGQVGTGAWQIALVVGVAMATAVFLDKGAVIPMQAASSAVLVATLMPPHTGGGLNRMVDALVGGFVGVVVVAAIPLHPVRRARQQAADILTVLGAALTECADGLHEQNAEKVRAALHSVRGTQPQIDGLRNAVEGGREVSRISPLYWNSRPRLEAIRAAVDPLDNAVRNTRVLLRRALTLVRDDEILDPRMIAEVEELGQAVEVVRRYMVAEPGEQPDAAEATRVLRRVAKGATKDLVEGAGLSSHVVFAQLRSIVVDLMQVCGITRLSAIALLPPTVQNPYVAPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBJ3</accession>
    <name>A0A231HBJ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigK_2</name>
        <name evidence="8" type="ORF">B7C42_01154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46189">
        <property type="protein sequence ID" value="OXR46189"/>
        <property type="gene ID" value="B7C42_01154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="23744" checksum="E8EBAFD448CA4009" modified="2017-10-25" version="1">MTGDPEFTSIRLADTDEAPSCPPGGGERAEAQRELATLLAAAATGNRDAFTRFYRATSARVFGLALRILRNRSAAEEVTQEVYLQAWTAAERYDAALASPIGWLMMLTHRRAVDRVRTEQSATVRDRVFGHAHLGRDHDTVAETVGQRLEEQAVLHCLDTLTATQREAVALAYYSGRTYREVAEYLDAPLPTVKSRIRDALKRLQNCLSGVASHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBN2</accession>
    <name>A0A231HBN2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46107">
        <property type="protein sequence ID" value="OXR46107"/>
        <property type="gene ID" value="B7C42_01071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="15119" checksum="03D625B100F7812C" modified="2017-10-25" version="1">MLAAAVVAEQAGLLTRVVLGVIRRNRYLMTGIRVAMAAVPLAVVLGFAGTAAATGPVQPGVTTPDAPAPSDEPAELRSASPQHVPTPQSAPRAAPKPEPKPSEPPAPREVRVGGFSAPVPDGVPDAVVDGVNRANDGIQGAINPNPEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBR6</accession>
    <name>A0A231HBR6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46147">
        <property type="protein sequence ID" value="OXR46147"/>
        <property type="gene ID" value="B7C42_01112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="36863" checksum="897296202E6E6E00" modified="2017-10-25" version="1">MPAPGSMRARDMDRVQARTLLDAAFDEGQLGADEYHDRSDRAATAKTVGELRNLVGDLQRPAGGAQWTPPPGPPRRTGRYPAHIRARDADRAETCRALDTALADGQLSAAEHQTLTDLTAAAETLGDLAELAADLQRPAEAPIDPRAGRQSRTAWFAGAVAVAVTAAAVGGYLLTHRVAPVPEPVVAAAPQVVRPMVIETPDLTTVAGFEKFRSDYQAKFGDTTVDNLSLFPDHASVDRTSARQLNRVADYSYRGGFMLSTAVTTRSADKPIFDLAAVNTSALGDLIARAVPLLKVPGGAVSHIGMGIDTISKVPTISIYVGNSFNENAYLEATPAGDPIRVYPFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBT8</accession>
    <name>A0A231HBT8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46167">
        <property type="protein sequence ID" value="OXR46167"/>
        <property type="gene ID" value="B7C42_01132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="586" mass="62584" checksum="5DD3024E3F111B0D" modified="2017-10-25" version="1">MVVGVLTAIGVIVVIAMIWLWPSRQHVDIPLPMQNGGGGAVQTEAGTVAMQDMGPCGSPSNGRSFPDTPQPPPTNSYTCQRSLVSIDSGPNKGSRTLLEIAPGPGQPDLHAGDHIRLVRQDDPSGTTIYSFDDFSRGMPLLLITLVFVAVIVVVARWRGLRAVLGLVFAFGVLVVFLLPALLDGKPALPVALVSGALILYAVLYLAHGVNLRTSSALLGTLSAMVLAAVLSWFALEVTHLTGLSEEQNTNVATYIQHVSITGLLLAGFIIGSLGVLNDVTITQASAAFELAALDEEASRREIFAAAMRVGRDHIASTVYTLVLAYAGGALPLLLMFSVAGRSIRDVLTGDAVAIEITRSAVGGICLALSVPLTTAIAVLLARPFGRRADFDDYEPEPAPRRAAVPAGRRRADSAAETTGSHRRVAARGETAGGRRRADGRENRAGHDHAGQRGGTDTGSHRRVEGRPGGPPTRRRTAPSTDATGGQRRVDDRADTGGHRRIDDRRTDTGSHRRIDDRRADTGSHRRIDGRTGEPTGGHRRVPSGRPHDEPRPSWPTRPPRPDAERHPRTDPQPRNRSGWPTTGYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC34</accession>
    <name>A0A231HC34_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781749.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46408">
        <property type="protein sequence ID" value="OXR46408"/>
        <property type="gene ID" value="B7C42_01374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011242086" evidence="1">
        <location>
            <begin position="23"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="126"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="38431" checksum="ECA4CB76DBD2A89E" modified="2017-10-25" version="1">MTVSTRLRRTWLALGVSATVAASGCGLTVESLPLPKPGQSGETYTLHAIFANALNLPDQAKVKIGGSDVGVVTHIATKNYQAIVDMDVRKDITLPRDSTAELRQATPLGDVFVALSKPKSDETTPMLKDGDTIGIDHTSAGATVEELLLSVSMLFNGGGVAALTKLTSELDSVVGGRPEQLASLIKQMTSVVTTLHANSDRIDSTLNGFDALTNTIEANHDQLGQVADSLPQMIGAIAENNKQIGDLLGKISTTSAALGDYAETSHDQLASLLENVHKLMDALSRAGNDLGPALDALHEIRPKVDASFKGNTLAVAATLTQLDVGLLTDPPHSKFWDLRDLQDMAGSLIQVLQIVYGRVTGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC70</accession>
    <name>A0A231HC70_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative FtsW-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rodA_1</name>
        <name evidence="8" type="ORF">B7C42_01450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46481">
        <property type="protein sequence ID" value="OXR46481"/>
        <property type="gene ID" value="B7C42_01450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="494" mass="52619" checksum="322E1CA09335E934" modified="2017-10-25" version="1">MSAPAPPSAGAFPSPPGGFAPAPPPSTRRNVELLLLGFAVVITTVALVLVEASQDQEITWDLAKLGFAYLALFGVAHLAVRRFAPFADPLLLPIAALLNGLGLVLIHRLDLADEQTAIHNSWSIPSPDANQQVLWTALGITLFIAVLVLLRDYRTLARYGYTLGLLGLVALMIPALLPGRFSETNGAKIWIRLPGFSVQPGEFAKILLIIFFASVLVAKRDLFTAAGRHVLGMELPRPRDLGPILLVWAACLVVLFFEKDLGTSLLIFATVLAMLYIATERVGWLIVGAGLLALGFFLAYNAFGHVRVRVATWLHPFDDYNSTGYQISQSLFGLATGGLAGTGLGSGRPSQVPFAKTDFIIATIGEELGLIGLTVVLMLFAVFVVRGLRTALAVRDSFGKLLAAGLAFTIAIQVFVVVGGVTKLIPLTGLTTPFVSYGGSSLLANYALLALLVKISDAARAPAPARRREAAPIAEAQTEMIRAETPRPEKGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCC4</accession>
    <name>A0A231HCC4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">serS</name>
        <name evidence="10" type="ORF">B7C42_01510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46540">
        <property type="protein sequence ID" value="OXR46540"/>
        <property type="gene ID" value="B7C42_01510"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="136"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="258"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="345"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="45829" checksum="8E1FB0981EAAEE15" modified="2017-10-25" version="1">MIDLRFLRENPEAVRASQRARGEDPALVDALLEADAARRAAVATADNLRAEQKALGKKVGKASPDERATLLAHAQELSAKVKEAESAENAADAELDSAHRAISNVVQEGAPAGGEDDFVLLETVGAPTEFDFPPRDHLDLGESLGLIDMERGAKVSGARFYFLTGYGALLQLGLLQLAAQRAVANGFTMMIPPVLVRPEIMAGTGFLGQHSAEVYHLGDDDLYLVGTSEVPLAGYHSGEILDLSDGPKRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEMFVYCRPENADAEHRRLLNWEKEMLAAIEVPYRVIDVAGGDLGSSAARKFDCEAWVPTQQTYRELTSTSNCTTFQARRLSVRYRDENGKPQIAATLNGTLATTRWIVALLENHQQADGSVRVPAALVPFVGREVLEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCN0</accession>
    <name>A0A231HCN0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <ecNumber evidence="6">2.3.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46723">
        <property type="protein sequence ID" value="OXR46723"/>
        <property type="gene ID" value="B7C42_01700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012036848" evidence="4">
        <location>
            <begin position="26"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="103"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="465" mass="48637" checksum="F2BCFC4CA425211F" modified="2017-10-25" version="1">MSESARDLARKLLSGTASGATGAPASTPVTSAGSSAAFTGANTKPARPRRGPGRQFADHPEVAAMVQKRAAIAAVHEHSGTPNPMFLVRESPNDTVIRWQGRDLVNFSAYNYLGLGNHPKVVQAAKDALDTYGASASASRIVAGEIPIYAELEQRLAAMYDVGDAMVTTSGYLTNAGVIGFLLGADDVAICDSLIHGSVISGVQWSGARRLNFRHNDPESLRSVLRMSRGNFDRALVVVEGHYSMDGTVGRVSEIAAIAREFDCAVMVDEAHSLGVFGERGHGIREHYGMPGDAVDIWMGTLSKALGSCGGFIAADADLIAAMKAAAPGVAMLTGGPAPSTIGAALAALDVLEAEPQRLRRLWSNAEHFRTLLGERGIDLGISEGTPICPVIVPGELRAGYVATTLLQNGIYAGAISSPAVPAGQERLRFFLTSEHEPAQLEAAADLLSEAVTDAARLPDLSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD88</accession>
    <name>A0A231HD88_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46829">
        <property type="protein sequence ID" value="OXR46829"/>
        <property type="gene ID" value="B7C42_01807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="23942" checksum="BAACB83D5B16FD39" modified="2017-10-25" version="1">MGTPPRQPDSTSPARAHTGRRRNEATRRAILDAALAQLATSEGGSITVDSIAAAAGIGKQTIYRWWPSKGAVLLDALLDRARQEVPAPDTGSVRTDLLLVADSTFAGAQQVSTAPALRALVREAARDPHLAELLQEFTAARRAAVRDILERAITRGELPGETNVDLLVDLLYGLFWYRFLLGHAPLDHTTATRLVDTLLPPVNTSRTAVDESADPFPRIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDC8</accession>
    <name>A0A231HDC8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46765">
        <property type="protein sequence ID" value="OXR46765"/>
        <property type="gene ID" value="B7C42_01743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13615" checksum="7F4DE3DAE1B3F3DF" modified="2017-10-25" version="1">MAGAESTQWQQLAEQSRSGDLLLDNESVARECLTACDQRLTDLQGMLDLARLAQAVSGFGDFDMGHALEGGYLKQATGEPNSVDQVIKDHIENVKSMREVMAQSIKHLTGQDVGNAAQIAATDPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDQ9</accession>
    <name>A0A231HDQ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndk_1</name>
        <name evidence="3" type="ORF">B7C42_00225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47103">
        <property type="protein sequence ID" value="OXR47103"/>
        <property type="gene ID" value="B7C42_00225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="2">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19054" checksum="23ECA266B91CCF55" modified="2017-10-25" version="1">MTSERTLVLIKPDGFARGISGEIISRFEKAGLGLSAAWIGTASREKADAHYTVTAEWLQMVGERALEDCSRRGGDPIKDYGSNDPIEVGRGIKAGLTDYLVSGPLFAMIVEGRNAVRAVRGMIGSTFPLEAAAGSIRSLYSTDSSELASSEGRPVQNVIHASGNLEEAEVECKLWFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDS4</accession>
    <name>A0A231HDS4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234656">
        <property type="entry name" value="M.Nce30759ORF245P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47123">
        <property type="protein sequence ID" value="OXR47123"/>
        <property type="gene ID" value="B7C42_00245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="39020" checksum="4D556D7E23BE3D85" modified="2017-10-25" version="1">MASQYRHAGKKLAAKFFVDGFNRVFSEIRHGANRNVPITVYYAYKQQDTRDVGTASTGWHTLLDGLIGSGWEVTATWPMRSERSGRMLSVGTNALASSIVLACRPRPEDAAATTRRAFIASLKAELPGALRDLLSGDVAPVDLAQAAIGPGIAVFSRYSRVREADGSDMSIKDALLLINATLDEVLGEQESDFDPDTRFAVKWYRQYGWGQESAGIADQLARSSDTSIGALERGGIFEAKGGKARLLPPAQLDGAWDPAADDRVSVWEATVRLAAVMAKDGADKVAELLPSVQTRANLDAVKELGFLLFHEAEKKKDAKDAILFNGLVSAWGDVNEQARKIGSAPRSAQQAFVFDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDZ3</accession>
    <name>A0A231HDZ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase</fullName>
            <ecNumber evidence="2">2.7.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dagK_1</name>
        <name evidence="2" type="ORF">B7C42_00282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47160">
        <property type="protein sequence ID" value="OXR47160"/>
        <property type="gene ID" value="B7C42_00282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="33247" checksum="4C54BEA43FA86E12" modified="2017-10-25" version="1">MTAIRSVALVTNPHSGHGRGLAAAAAAAARFAERGVRVREIRGADAAETVRLVRDSVRGPERPDAVVCAGGDGLVCVTLQAIASTGVPLGLLPGGTGNDLARELGVPDDDPRAAADIVLGGCVRTVDLGAIESTPDPEHAQGWAAGIEPAVAHRPMRFATVAGTGFDARVTLRANRMRRPKGSLRYSFAAVPELLGQLGVPYRIELSGEPGRAGERVVETEAVMVAVGNTRTYGGGMLICPDAIVDDGLLDLTVVGAMSRLEMVRLLPALAAGKRIDHPAVGHYRARAITLTAAVPATADGDPAGLLPATFRAEPAALAILVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE47</accession>
    <name>A0A231HE47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">betI_1</name>
        <name evidence="6" type="ORF">B7C42_00167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47048">
        <property type="protein sequence ID" value="OXR47048"/>
        <property type="gene ID" value="B7C42_00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="25972" checksum="5396F8A1744AADF6" modified="2017-10-25" version="1">MARTTTTGSSTIPPTPADGAPPVRRRLTAEARKSSILAAARRAFSETGDMNGTTVKMIAEHSGISEGIIYRHFESKDQLFFEAVVEPLKSAVDDLVAATAVVDRDQPLTPQRQLETLKGLYRQLISTLDEVLPLLGLVLFGDPQVARRFYRENFAVAMDRLAEAWREVEDRYGFPFESPDISARAVMGMALMQALETRHGTAKKADRDRAITLISEGTVKGFFPVIEGAESDDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEG1</accession>
    <name>A0A231HEG1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iphP_2</name>
        <name evidence="3" type="ORF">B7C42_00334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47212">
        <property type="protein sequence ID" value="OXR47212"/>
        <property type="gene ID" value="B7C42_00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011259544" evidence="2">
        <location>
            <begin position="32"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="33022" checksum="A3E97CEF22901B7C" modified="2017-10-25" version="1">MPISHVLRGSVAGLAAALIAVLPAATTPAFAAPPLVHTAPATSDQQQSLGISAPNARDIGGYPTQHGGGKIRFGLVYRSDALNRLTPADQQKLASLQIGKAIDFRSPNEMKAAPDQLPSSIPYSAQSIWDPNNDFYVMVSSTIAGGPQMQQDKLGDGKAAQIMRDYYRWLVTDGAARAQFSAALKEIASSPNAVLYHCTSGKDRTGWMTAILMSALDVPKGQIYKDYLASNDYLAASNKAQMDALVQRGLVTDPSLFAPILGVQADYLDASFDQVQQSYGSFDRFLSDGLGVDSATVDALKAKLLDKPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEH0</accession>
    <name>A0A231HEH0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uppP_1</name>
        <name evidence="14" type="synonym">uppP</name>
        <name evidence="15" type="ORF">B7C42_00506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779927.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47383">
        <property type="protein sequence ID" value="OXR47383"/>
        <property type="gene ID" value="B7C42_00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR47383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="33879" checksum="78B7024975B27A68" modified="2017-10-25" version="1">MLTYFQAIVIGALQGVTELFPISSLGHSVLVPAWLGGSWEKLVTEGDSDNGTPYLAFVVALHVATAIALLGYYWRDWRDIIVGFVTTLRTRRIETSSQRLAWLIVLATIPVGVLGLLLEHPLRTMFATPIYASIFLTLNGVVLIVGEGLRRRNAPSLAEYGRRFAADEARADAQARGVALEEDLEVPSDERLAALSVKDALGIGLAQSGALLAGFSRSGLTMVGGLLRGLDHEDTAKFAFLLATPVILAAGVLKLPELAGPEAAGIHGQALVGAIVAGLAAWFAVRFLERFFKSRTLLPFAVYCLVAGLLSIIRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HES0</accession>
    <name>A0A231HES0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock-like protein CspLA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cspLA</name>
        <name evidence="2" type="ORF">B7C42_00328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47206">
        <property type="protein sequence ID" value="OXR47206"/>
        <property type="gene ID" value="B7C42_00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="9318" checksum="DD877040416C39B7" modified="2017-10-25" version="1">MAIGTVKFFRPEKGWGAIASAELPDGCDAWVHFNAIEGEGFRSLDAGERVEFDYESAQQDSFRYRATRVRRIDTDGRRSSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HET8</accession>
    <name>A0A231HET8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47450">
        <property type="protein sequence ID" value="OXR47450"/>
        <property type="gene ID" value="B7C42_00575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="18836" checksum="D2776540B0CD4C9E" modified="2017-10-25" version="1">MGVNQRAQIVMSETEITEFLERSRIMTLASLGKNGTPHLTAMWYGLVDGEIWFETKGKSQKAVNLRRDPRVTVLVEAGDTYDQLRGVSIEGRAEIVEDPEALFKVGVSVWERYTGPYTEELRPMVEAMLNKRIAIRVVPERVRSWDHRKLGMPAMPPGGSTWPVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEZ4</accession>
    <name>A0A231HEZ4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">gatC</name>
        <name evidence="2" type="ORF">B7C42_00501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503944.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47378">
        <property type="protein sequence ID" value="OXR47378"/>
        <property type="gene ID" value="B7C42_00501"/>
    </dbReference>
    <dbReference type="GeneID" id="66720792"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="98" mass="10317" checksum="5E513FF685F3F980" modified="2017-10-25" version="1">MSAISRDEVAHLARLSRLALTDEELDLYAGQLDSILSHVQVITEVAADVPATASPNPTANVTRPDVVVPGLSPDEALSGAPAVDEQRFMVPQILGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFA4</accession>
    <name>A0A231HFA4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">L-ectoine synthase</fullName>
            <ecNumber evidence="4 7">4.2.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">N-acetyldiaminobutyrate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ectC</name>
        <name evidence="8" type="ORF">B7C42_00623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine</text>
            <dbReference type="Rhea" id="RHEA:17281"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="4.2.1.108"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ectoine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.108" evidence="4 7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779838.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47498">
        <property type="protein sequence ID" value="OXR47498"/>
        <property type="gene ID" value="B7C42_00623"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033990">
        <property type="term" value="F:ectoine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06978">
        <property type="entry name" value="cupin_EctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01255">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010462">
        <property type="entry name" value="Ectoine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39289">
        <property type="entry name" value="PTHR39289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06339">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="130" mass="14607" checksum="9D6DBE6A39DF54C9" modified="2017-10-25" version="1">MIVRTTAEITGTDRDVAAENWRSKRIILGGDGVGFSFHETTIQPNTVHEFHYQNHVEAVWLVEGEGTLTDLTNDVTYDLAPGTMYLLNGHERHRVETRTLMRMLCVFNPPVTGKEVHDENGVYPLVAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFS5</accession>
    <name>A0A231HFS5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47800">
        <property type="protein sequence ID" value="OXR47800"/>
        <property type="gene ID" value="B7C42_00925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393873" evidence="2">
        <location>
            <begin position="33"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="24849" checksum="620EF79574881F0C" modified="2017-10-25" version="1">MPKVAHRRMSRPMLIAGMLPLAVILGTGVAAASPGDLVLAPVDAAQAPVVPPLAVDWQTLAHDVQGLIPFPVPLPLPPADGPVVQDNSTAGPQNAPVDASAPAVTAGAPPADTAAALPVEPAAATPAPVADALPVEDQHPVETFCAQVPADPDRCAATVVDAGVGAAIGAGIGAAVSAPLAIPAAALGAAAGFVVGLPFLPTGVVVGPLVGAAVGAAIVAGPAAALGGALGGAVGAIVGLTAPLPPNPAPTDAPAPADALVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFT4</accession>
    <name>A0A231HFT4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47843">
        <property type="protein sequence ID" value="OXR47843"/>
        <property type="gene ID" value="B7C42_00968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="38" mass="4080" checksum="1F7D271E50711AB9" modified="2017-10-25" version="1">MFKTLIAFAAGGAAVAGAPAAWRFLARHSNTQVHQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG35</accession>
    <name>A0A231HG35_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_00957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47832">
        <property type="protein sequence ID" value="OXR47832"/>
        <property type="gene ID" value="B7C42_00957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="466" mass="51433" checksum="35D08E753A5645A2" modified="2017-10-25" version="1">MPALHAQHSVADKEYGAHPVPPNARLGRWQVTMSYWSLLSAMVWLFYGALAASLYGTRDAMIAIALSTVVFALANIMMTRLGIRHGVNSTLLTKSLFGRWGSLFTALLVAATVLYYAIFESSTLAVAFQSYVKHGDIRLWYAVIVVVMLPLMLGSVQSWMAKLNGVLLPFYLVGLVSILIAAGVKFGHGSHWLSFSGVVPPEGRSFPGWILCFVLYMGIYITMPTTIDFARFARREDERFHEVVTFGWVFYLLLFILNGFAGIYLVQLVLPTEPASETGVVQAILASLGWIGLLFIVISQTRVNTLNYYQSSTNFERILSTVTSVRLPRFVWVTAVAVVVFLMMLTDVFSYLQTALNWQGVLVIGWVGVVLTHFAVSRRDRRFGPVVDESMPRIGWGLIAWIVPSIVGILLLEVSSVPATARQSAQLIVLVLSVALYTVTYLLTRRADDAGPAARVDGAEVPSAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GST4</accession>
    <name>A0A231GST4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000086">
        <property type="protein sequence ID" value="OXR39683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39683">
        <property type="protein sequence ID" value="OXR39683"/>
        <property type="gene ID" value="B7C42_08241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011226225" evidence="2">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="182" mass="18640" checksum="A88D127906EA1CC0" modified="2017-10-25" version="1">MPRTARIAAVAATFAVATAAVTGCSSSDNDKATSTPVMPPAATIAGHTTPASSTPSTPGVYQPLDTGKGKSGLEASILSVEDADTRYGPGTVVTFQIVNTTQTPWEGYNWSEPSLVYGPAGTPAEKITSLSEGYGAGVQGTIPPGSRQTVKTAYKVSKSQLNPAVITAGSVVWQGDFATFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT28</accession>
    <name>A0A231GT28_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000066">
        <property type="protein sequence ID" value="OXR39779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39779">
        <property type="protein sequence ID" value="OXR39779"/>
        <property type="gene ID" value="B7C42_08144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="16127" checksum="A358A3320C840406" modified="2017-10-25" version="1">MLARRIGNHVFLSPSGKSGFLTPDFLVYHCLPSPYQDVRVTDTVLVGEVLSPSNTQSDMEAKKGRYATAGIPWYREVTLARENSAIATVRAHALETGHGKFPEGVRPPRSANYVLAGEWTVEDENGIQFEFRFPITIPWSELEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT76</accession>
    <name>A0A231GT76_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000066">
        <property type="protein sequence ID" value="OXR39782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39782">
        <property type="protein sequence ID" value="OXR39782"/>
        <property type="gene ID" value="B7C42_08147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="22429" checksum="19390C151DB6814F" modified="2017-10-25" version="1">MKADPPSIDGLTFQHYTATEARAVRGQVEQIFRDSYTDAIESGEEFEAPEAFMHRFDTYTDPSRGQGFELVIARIGDEPVGQAWGWPLGPGTRWWSGLELDTGDLATFTAETGTRTFALSEIMVRKKFTGRGAARALHDELLSDRPEQRATLLVRPDNERAYRTYTRWGWIRTGTLRPTWPDAPKFDVLIYEPVQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTA4</accession>
    <name>A0A231GTA4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000056">
        <property type="protein sequence ID" value="OXR39857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39857">
        <property type="protein sequence ID" value="OXR39857"/>
        <property type="gene ID" value="B7C42_08069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="559" mass="58608" checksum="0E83F3766FE2F621" modified="2017-10-25" version="1">MTSHVIADPTATPATPPRTAGWETLSAAMTAEAAPIADRDDLIVTIAPGAAHGHPAVFFPARAAIELDGDLLKVDPRTARPDRLADRARYAAVWGAFTHECAHAQHTRWTPPPVANPAVVEAALLLEESRIETAQVRRRPDDRHWLRASATEIIIGDTGGPAAASSLPATDYAAAHVAALLLGRVDGGILEASECGPAAAAAEKILGSVKLKALRAIWREAHNTADDDTARMLELGELWLDLVGPDPHADPDPESALSAAIAETVANIGAAVEAEPIPVDPADAARAAARAEAAVEAAAEKVARRVFGRAPSRRPTRAPKSEERSAARVLARALNTASQRERAVVKSTSAVPPGRLRMRGAMAREAQRAAGAMPTAEPFTRTTRRATPIPPLRVGIACDVSGSMAAYAAPTASAAWIVAQAAELATMPAATATVTFGSRVSPITYPGTAPARVTEFTCPDAEEALDDAIDALDGALALSRPENTRLLVIISDGYYGGPRRRRAQQRIDRLRATGCAVLWLTPDIEYRRPLANTTVHAIGDPTTTAAAIAKAAVTAVRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTE0</accession>
    <name>A0A231GTE0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043540.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39897">
        <property type="protein sequence ID" value="OXR39897"/>
        <property type="gene ID" value="B7C42_08043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="26231" checksum="1EC6EBF91367295F" modified="2017-10-25" version="1">MAEVYTPPLANPSPGGLYSVAALIDITGTSRLAEDVQVETWNCGPSWVLPIHCEDDFPDPSPMGAEPRNNWLDNVFEGDVVGADDDCSALVSEPEAGQRAQQLLRLQEPVNVEKQLVPRLLAMAGTPTSVTGLVVAVGALEESVAEFGFTGVIHAAPHLAAALQNAQLITRSGQYLLSPSGHRWAFGSGYAGLNETLVATGPVTVQRDAPVLTHGPDYTHNQRLSTVQRDVLVLWECWTKAVTIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU31</accession>
    <name>A0A231GU31_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-arabinolactonase</fullName>
            <ecNumber evidence="2">3.1.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araB</name>
        <name evidence="2" type="ORF">B7C42_07794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778626.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40130">
        <property type="protein sequence ID" value="OXR40130"/>
        <property type="gene ID" value="B7C42_07794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050021">
        <property type="term" value="F:L-arabinonolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="31"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="33053" checksum="FC5DA325D7332C20" modified="2017-10-25" version="1">MTNPVDTVAAAVAAAKAPTYEARRISTGYSWPECPRWHEGTFWFSDMYTGTLKTLDAAGNATVVVDANARAAKTDVPIVLGGFGWLPDGRLIVVSMHEKLVLIHGGGGPEDLSVYADISEHCPAAANDMVVDADGRAYITQLGFDLFKGEDPVPSPLIVVEPDGTVGTPEKVGPLLCANGIAVSADGTRVYTAEVMAFKITVMDRAADGTLSNPREFATCPFMPDGIGLDAEGGVWAAMPGGGYVARFTEQGITDAVSLPLENGIASACLLGGPDRSTLYLTAGYEVFDFEKSAREALGGIWVADVPQHGGDTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUI8</accession>
    <name>A0A231GUI8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40252">
        <property type="protein sequence ID" value="OXR40252"/>
        <property type="gene ID" value="B7C42_07677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="8674" checksum="9EBE181E91BA4B65" modified="2017-10-25" version="1">MARARVVDVYIPVVPPSAGIGGVGPILILPVVIAAAAVVLAVLVAVAYPTPHHRYYDRPCDPFCATTTVSSPSAQYPFGGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUL5</accession>
    <name>A0A231GUL5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40320">
        <property type="protein sequence ID" value="OXR40320"/>
        <property type="gene ID" value="B7C42_07581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="5160" checksum="9A05C961AC045D08" modified="2017-10-25" version="1">MTQLLILLEKGINMDPNDVLNLLNSGAILASNLLSVAAQALSFVLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUM9</accession>
    <name>A0A231GUM9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40333">
        <property type="protein sequence ID" value="OXR40333"/>
        <property type="gene ID" value="B7C42_07594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="413" mass="45171" checksum="F29CE4573D4824A4" modified="2017-10-25" version="1">MLVRIRYGQLELLRATQFAEPFDIASSTTTPTAAKEGDPGVTPHMEPNENTRSLAMARTRAHSADPRIHPHRPQTGPDRGMAVYQSLVTADDDSDEGGPTARARSPWADDGPWRGRGQPPTRDGINPYLPSSGLQISPHQPPVSGGPPTPESRDEGTSSRPEEAELDRIIAAELEEHRVFEGFATVGRQITHSELAEQTSLSKEHIGKILRGQRRVNVRTLQTFAAPLGLPHEVRDHLAELILRNETSARAAPEPGPAPADMKQQLTATRFPAILLTAGLFDIAAANDAAVQKLPRLLEAGNFLRWLVYDPMARLVFAGSAWHEVTTVFTYALHYLSRGTVPEQARAALIAELSTQPEFPRMWTARIDGQLFPLHTTIADPTHSSQATPIALTVSTPWRAPARHLNISLVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUN5</accession>
    <name>A0A231GUN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress response kinase A</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">srkA</name>
        <name evidence="2" type="ORF">B7C42_07601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40340">
        <property type="protein sequence ID" value="OXR40340"/>
        <property type="gene ID" value="B7C42_07601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="71"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="33152" checksum="4246260E080E356B" modified="2017-10-25" version="1">MATSISPDRAAELHAAVVEACNHIDVDPSGAELIKYTVNAVYALGAPIVVRVGSGDVGHYRGTRLIETANWLTRHDAPTIRLVDAQQPVFIGDFTITFWHKAHHRERWTASDLAHPLRALHLLPTDDADLPHWDPFETARHRLAAADDGLSADDLQWLQDAWLEVEQNYRTAEFSMPFVLLHGDPHVGNLLIDHRDRIVLCDLDESAVGPMAWDLVPQAVGATRFNRANFYRDFAAEYGVDVRDLPEWPVLARIRELIMVTSVLPDLGQRPGIAAEQAHRLASLRSGDAAAVWHPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUQ4</accession>
    <name>A0A231GUQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40275">
        <property type="protein sequence ID" value="OXR40275"/>
        <property type="gene ID" value="B7C42_07613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="240" mass="25423" checksum="36024F3056D1FC35" modified="2017-10-25" version="1">MSSVAARSNSYAVASRSCGVQSAGALSIAATRRGHARASMTCSAVSRPKTSCRCGVQSGRRGCPVSVARAEGSRRRRDQRAAAGRSSGSGRWLAASVSSVSMSSPAAAAVSRWLASTGHQGSLVMRVSRRLASGCQVWVAVLRSPRVSVTRVTSCVWWSRSRTRKRVGPVGRRSVSGMWLAARHTASSARSSRLPSRGRAHTGAMAAVHSRASVVMWVARSATIRWRARSWSAIVASARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUZ1</accession>
    <name>A0A231GUZ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator RhmR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rhmR</name>
        <name evidence="5" type="ORF">B7C42_07505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40447">
        <property type="protein sequence ID" value="OXR40447"/>
        <property type="gene ID" value="B7C42_07505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="81"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="29749" checksum="CAE7D97C6D18BC9A" modified="2017-10-25" version="1">MTSISSTSVGSVMEQHRLPPSMIERVTLIMDCFDRPHTRRALEHVAQKTGLPRSTAYRILEQLVRLRWLDRTETGYKLGLRSLGLGGREIGRGALRAAAAPKLLELALRTDLVVHLAVLDGTEVYYLDKVGGRAAFDVPTSVAGRAPAHCTAVGKAMLACMTPEQVDVEYRGGLERRTARSIESIFVLHRQLSQIRCGTGLATERGECFAGFGCVGMVVHGPDGPVGAVSLTAAAYGSFERVVPLLVKAVRAVSDDLCKYQGPNEPDQLVPSPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV44</accession>
    <name>A0A231GV44_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40507">
        <property type="protein sequence ID" value="OXR40507"/>
        <property type="gene ID" value="B7C42_07446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="60" mass="6794" checksum="74C6A09D7AFB3BAE" modified="2017-10-25" version="1">MYLVWNHNGTRHELLIGEAEGSTREANLKAGWAIAHQHQLLTPHGRDKWQATRQPPLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVG0</accession>
    <name>A0A231GVG0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40613">
        <property type="protein sequence ID" value="OXR40613"/>
        <property type="gene ID" value="B7C42_07298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012669329" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="36141" checksum="1308089FA85871DC" modified="2017-10-25" version="1">MLAAIAAIAAALCLVSGCGFDPSAVSVPGSGIAGPKYGLRIEFANTLNLPSRAKVTVNGLRAGIVRDMTLIDAGNGHDSYVVVDVDIMSSVQLPVGTTAELRQPTILGDVSIALTTPPSGGGATLAPGATIGRAQTKPLLQLEDTMNVMAAFVQGGGIQRAQEIINRANAILPSDPKDTASISEVLGSDIKDLAAHVDAVDSVLDGLRGDTEVILRRTPDLDYLLTDAGVDQAAASMTSMIGLITLYDGFKLLTESLRWVGPLAQSGAAAARAFVPLLFTSRPLDLSAPSNLNKIVSILHDEVIPFAEHEPKVNITGVQVGNDSGAARVSDNDRINSILTALHAIGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVM1</accession>
    <name>A0A231GVM1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40605">
        <property type="protein sequence ID" value="OXR40605"/>
        <property type="gene ID" value="B7C42_07290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="41" mass="4827" checksum="1F6869B112DA14FD" modified="2017-10-25" version="1">MIALTLPEIRRLLVALVLTTSHGADHIWTWSHWRRRGHPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVM6</accession>
    <name>A0A231GVM6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40673">
        <property type="protein sequence ID" value="OXR40673"/>
        <property type="gene ID" value="B7C42_07231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018723">
        <property type="entry name" value="DUF2254_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10011">
        <property type="entry name" value="DUF2254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="455" mass="49732" checksum="4211B550266101A7" modified="2017-10-25" version="1">MHGISLEADRWRERLRTNLWFVPTLEVLAAVALFALTFTLDRAAYHSGTNLPTWVLGGTPDAARQVLTSIAAAIITVVGVVFSITILALTLASTQFGPRMLRNFIRDRGTQLTLGTFVATFVYAIAALVSVGEDFVPHISATVSIGSLVVDLAVLIYFINHIGGQIQLPNVVADIAREVRTAVDANVDITVSGAKHGPSARELRDLLARSGGEVRTSNSGYLQYIRYERLVRLAAEADAVIHLPYRPGHFVTEGQVIARVWPAQAAKGIEKKFSRGHVTGSMRSLVQDVSFGVDQIVEVALRALASATNDTFTVLTCIDWLGDCLSRIAVTWEPNPVRRDKDGHIRVLAAQVSYERLVQRAFEKIRQAGAGQPAVMIRQLDALAQIADRVTDPDRLRVILEQATMIEHAVPLISEEPDRADVLRRCHALHAQISAERAELATRTRKSTPASNPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWL2</accession>
    <name>A0A231GWL2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779458.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41020">
        <property type="protein sequence ID" value="OXR41020"/>
        <property type="gene ID" value="B7C42_06986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29877" checksum="F48B8DE0E7ECC04C" modified="2017-10-25" version="1">MSGVQPLLPDWAADDIDPRIPSPARVYDYLLGGFANFEVDRSVAAQMIEVIPEVPRTARANRAFLQRAVGFLAEAGIDQFLDLGSGIPTAGNVHEIAQRVVPGARVVYVDIDPVAVTMSRKLLADNPNATAVHGDFTDIDGVLEHPQVRELLDFDRPVAVLLVSMLHFVADDDLAATVFERLRATIASGSYLALSHLTSEGPPEQMDRMLAVTERVTGRGDRLRTRAEIMELLGDLVLVEPGLEYLARWRPDPDEPLPEVRPLDGYAGVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWL8</accession>
    <name>A0A231GWL8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cadmium, cobalt and zinc/H(+)-K(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">czcD</name>
        <name evidence="8" type="ORF">B7C42_06983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41017">
        <property type="protein sequence ID" value="OXR41017"/>
        <property type="gene ID" value="B7C42_06983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="35374" checksum="3AC347592BB6D88A" modified="2017-10-25" version="1">MGAGHTHGSGHGHAHSHAHATPDSDRRWLAGALAVIVVFLLGEVVVGVVAGSLALLSDAAHMLTDAASIALALWAIRLAARPPAGRMTFGWKRVEILSAQANGLTLLVLSAWLLYEAIRRLIEPPAVTGGLVLATALVGVVVNLAATWMISRANRSSLNVEGAFQHILTDLYAFLATAVAGVIIMLTGFERADAIATLVVVALMVKAGVGLVRASSRIFLEAAPADIDPAAVGVGMAARDGVVEVHDLHIWEITSGSPALSAHVLVEPGRDCHAVRQELARWLAADHHIEHATLQVDHAQPELIELGARPSGHCAQSHGPARHSRDVAHTHESGNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWR5</accession>
    <name>A0A231GWR5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Demethylphylloquinone reductase NdbB</fullName>
            <ecNumber evidence="3">1.6.5.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndbB_2</name>
        <name evidence="3" type="ORF">B7C42_06837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.12" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41067">
        <property type="protein sequence ID" value="OXR41067"/>
        <property type="gene ID" value="B7C42_06837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="453" mass="48520" checksum="BAE4CC3CCBC3B411" modified="2017-10-25" version="1">MSPAKIVIIGGGFSGVECARYLERHLGAEEAFIQLVTPDAGLLYLPLLPQVASGVLNPRSITVSLRRVLRRTEVVPGMAIGVHPDTRQVVVRGSAGTESALDYDHLVLVPGSITRVLDVPGLDEYGFGMKTLAEAMFLRDHVLQQLDIAAVRGGEEDDRERLNFVTIGAGYAGTETAAVLNKVTRAAARRYFPKLESGMVRWHLVTHGDRIMPELGQRLGEQAKRNLAERGIELITGASAKEVTAHGVQLTNGRFIPTRTVLWTAGVVPSPLAGHLGAATTKGRIVADAEFTVPGLDGVWACGDAAAVPDLTADAGTLCAPTAQHAMRQGRHLGRNLVAALRGGRPTPYRHQDLGMVVDLGGADAVARPLKIGLRGVPAQFVTRGYHLMALRTLVARARVAFDWTVHGLSGDDFLRIGYGDYTTHTIGGFEQTGCYLPAEEVPRTLKALCDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX39</accession>
    <name>A0A231GX39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41135">
        <property type="protein sequence ID" value="OXR41135"/>
        <property type="gene ID" value="B7C42_06731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="43" mass="4964" checksum="E4F78257781D3D07" modified="2017-10-25" version="1">MRKQRSTFPAQADQRRFGTRPVPPRTVTHSKGGWPRHGRHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXJ4</accession>
    <name>A0A231GXJ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41231">
        <property type="protein sequence ID" value="OXR41231"/>
        <property type="gene ID" value="B7C42_06629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15803" checksum="A051D3BD4CF66B32" modified="2017-10-25" version="1">MNHAQNRQRSRSGAAPAAQRPSKQRARARGELTGAALRVTYDSSWVRSSLSQLDYLYSARAVDVDLRPVIDFAIRWAPFGGAGAGELLVSFGVGRRRFVEMVHAGLRPRRTDNQEARWLKRGLLDALASAWKVGDSVAARSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXK7</accession>
    <name>A0A231GXK7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phnPP</name>
        <name evidence="3" type="ORF">B7C42_06500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.57" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41357">
        <property type="protein sequence ID" value="OXR41357"/>
        <property type="gene ID" value="B7C42_06500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102560">
        <property type="term" value="F:5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102561">
        <property type="term" value="F:D-ribose 2,5-bisphosphate 2-phosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="30108" checksum="9696F3FC6405AA7D" modified="2017-10-25" version="1">MERVRIDLHTHSTASDGTDTPGDLMRAAAAAGLDVVAITDHDTTSGWDEAIAALPAGLRLVRGMEMSCVGMGEDGWPVPVHLLAYLFDPADAAFAAERERLRTERVSRVRAMADLMVADGLPIDPDAVLAAAGPAAGRPHLARALVEAGVVPTVGAAFEDLLAPRGRYYVEKADTPLRQAVEMVAAAGGVTVVAHARARTRGRLLAIDDIRDLAGHGLGGLEIDHPDHNPADRAVLRELARELDLIGTGSSDYHGADKPVGLGECTTDAEQFERLAEKASGVAVIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXM4</accession>
    <name>A0A231GXM4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-3-phosphoglycerate synthase</fullName>
            <ecNumber evidence="2">2.4.1.266</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gpgS_2</name>
        <name evidence="2" type="ORF">B7C42_06471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.266" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41328">
        <property type="protein sequence ID" value="OXR41328"/>
        <property type="gene ID" value="B7C42_06471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="32872" checksum="2B7D72465D1A54C8" modified="2017-10-25" version="1">MTFDWTATHTWDRPQWAIDELVDAKDGRTVSVVLPALNEERTVADVVASIRPLLGTLVDELVVLDSGSVDATAERARAAGAQVVTREQAVPELEPVPGKGEVLWRSLAATSGDLVAFVDSDLIDPDPMFVPKLLGPLLTVDGMHLVKAYYRRPLRQGAAVEQHGGGRVTELVARPLLAALRPDLSKVLQPLGGEYAGTRELLTAVPFAPGYGVEIGLLLDTFDMLGLSAIGQVNLGVRTHRNRPLSDLGVMSRQILGTVLGRSGIRDSGAALTQFPLVGEEFTALSTDVHLADRPPMNTLRPTEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXQ8</accession>
    <name>A0A231GXQ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41311">
        <property type="protein sequence ID" value="OXR41311"/>
        <property type="gene ID" value="B7C42_06709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="37458" checksum="00F6D7A2D5BD21D4" modified="2017-10-25" version="1">MTTFGVNAFGVGRGPQRFATMTELAREAEDIGCTAVWTSELYSRSATVPMAALAAGTSTIRIGSNIAYGVGRSPLMWAAEARDLDELSGGRIILGIGNGTPKMMEAWHGVPGEAPAARMAELLTVLKALWRLHEGPVHHDGRFYHVHVSPTSDVPEPIRPEIPIWIAGVNKLMLRTAGELADGLVGHPMYTAEYVRGPVADEIATGAALSGRDPADVTIMGIRMCAINDDVELARRQAAYAIGQYAASRVYDRLFALHGWSAEQQRIREAARDRDSAALISAVTDDMIDTIAIACRPAEFPAALAAIPEGFDHLDLIAPPWGLSDHETRAINAEILAGLRSHLAHTVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY44</accession>
    <name>A0A231GY44_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41516">
        <property type="protein sequence ID" value="OXR41516"/>
        <property type="gene ID" value="B7C42_06408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="36391" checksum="606CF64C019BC89E" modified="2017-10-25" version="1">MSAATGPVRDARTLLGMDTRPAWLIAAFYLISEAALSLSSAQQTRHLWPVLAGLAVTVAATAALLRIRPDPLPLPATAALAASIPATAALTLFNLPIPPTSVAQLWSFGCGTVTATFMCVRGRTGAAWAGLLSMIATSAVWSWQSGQGFGHGVAISAINLGPLMMATFFAYTLRPAARAIFRLREESTRQVGSEAAAAAALDERRAQIQRLDDMVRPILERIAGPQPLDDRTRDDCSLIEAHLRDTLRAPVLAAEPVTTAARAARLRGVDVVLIDDHGLDDLPAATRRRVLGTVAAELATTAAGTVHVRILPPHRAILATVVVNDPGSGIRRIEIDAPGTRAGAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYB5</accession>
    <name>A0A231GYB5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41614">
        <property type="protein sequence ID" value="OXR41614"/>
        <property type="gene ID" value="B7C42_06255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353202" evidence="1">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="13462" checksum="A8013A59B1379672" modified="2017-10-25" version="1">MSATLALTAQDQLTVRTAAYGAVSLLAAGSNKPHKAATAGSTALLSATGTVGHVLAAKSRDIKLAGKSVAELADQVLPALTAAVTLLEQSDPAEADNFRTTVQIAIEAATTEVRPGPVTTEMIRKITAAMHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYK2</accession>
    <name>A0A231GYK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator EthR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ethR_1</name>
        <name evidence="5" type="ORF">B7C42_06311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783100.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41670">
        <property type="protein sequence ID" value="OXR41670"/>
        <property type="gene ID" value="B7C42_06311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="23721" checksum="D3FE0332B5B0145E" modified="2017-10-25" version="1">MASLTRPGSRSRERDERRDTVERRVLAAVDRLLDTGVTYTELPVARIAAEADIARSTFYRYFPDKSQLLIRMADLATDDQFRTAELWWAADHVDGEAGVVTAMRLMIAGTRAHHRVLRALTEVAGYDRDVGRYWQERVQRFTELVRLRLDRERAAGRIPADLEVEATAIALTCMVERAIDFTFGAGHPVDDEQLARALGRAIWQTVYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYU5</accession>
    <name>A0A231GYU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">menG_6</name>
        <name evidence="2" type="ORF">B7C42_06121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41779">
        <property type="protein sequence ID" value="OXR41779"/>
        <property type="gene ID" value="B7C42_06121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="30090" checksum="C9E7AE81FD7DE822" modified="2017-10-25" version="1">MAAAMTYSMAVGDRDAARLALLDQHYNPSSRAFLESVGVWSGATVADIGCGHGAMTAWLAERVGPDGIVYAVDASAEQLEIARRLVGDLPQVRYVHARIEDAPLEPGSIDWVYSRFLLMHVADAAAALTAMERMLADDGALLLEMSDVGALRFVPADDPAADLWREWWFALGRARGAAHDIYDRTPQLLTEAGFIIARRDRFQPVSAMPEAKMLHALGFEQCVPAYLEHAGADPAAIDAHRAFLQRVVPDTDIAVELYATSQYFARKRPRARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYW2</accession>
    <name>A0A231GYW2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41803">
        <property type="protein sequence ID" value="OXR41803"/>
        <property type="gene ID" value="B7C42_06145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="21740" checksum="BEC99EE2C3A9F2B0" modified="2017-10-25" version="1">MRSHTRLPHISGHRRIRATDILRVDILRVVTVVTGIAVAATLVACSTDSPASEGPNTVGYRSMTQVPAMNTSGETDDGSGRIERTPSGPAEVPSAPTSDLPIVSGSGTAAGDRPPAGTAFPGEGISGEAAEQLQQSADAGHQPWRLDEDAVARAFVSGRFGWSRPAITHDGAYLAVATGPNGQRVSLQLSQPARKNNGGVWVVESGIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZA4</accession>
    <name>A0A231GZA4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular esterase EstB</fullName>
            <ecNumber evidence="3">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">estB_8</name>
        <name evidence="3" type="ORF">B7C42_05921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41937">
        <property type="protein sequence ID" value="OXR41937"/>
        <property type="gene ID" value="B7C42_05921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624274" evidence="2">
        <location>
            <begin position="33"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="41435" checksum="0629FC646A9F29DC" modified="2017-10-25" version="1">MKKSFRRSCTSAAIVAAAAALTVGLTGVGAGADPVGDQQQEQQLAEMITHGLKNPSAHAIADSGSSGTGSACTSGSGAGSGNGSGDCYGGSGSSSGSSGGTSSDTVGYGPAQSSFLAAFGYGLLNPDVAPPGTNDWNCKPTAAHPEPVVLVHGTWENAYDNFSYISQPIHDAGYCVFTFNYGKSNLIQGGGLGSVLPGTNGTGYIQDSSKQLAQFVDRVLAATGSQKVNLVGHSQGGAMSRWYLKFDGGAAKVHHMMTFGATNHGTSLDGIGALGRMINNLGIDVLGLVEIFVGHAGIQQTIGSDFVNQLNAGGDTMPGVDYTVVGSRYDEITNPYDLTFLKPGPGATVDNITLQDGCEQDVSDHLTMMYSPRVLSIILHALDPAQTPALTCSFNPWLVGGGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZG8</accession>
    <name>A0A231GZG8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42003">
        <property type="protein sequence ID" value="OXR42003"/>
        <property type="gene ID" value="B7C42_05987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="34623" checksum="0BF0B9DB1D370319" modified="2017-10-25" version="1">MQTESTTLPRRLLGRRLIELREAANLKSDEAAKLAEIGRQTLWRLENGRTSEVKRPIIRALCRVYEVNEEDQNGLLWLADECRKEEWWQSYSDAIVYADQFLSLEQAATRVDSFQLTLLPGLTQTADYRRAKARYYKPELRRSRLVDQHIQYNEQRSFELLSKRQARLADSSNPLTMQVLLGEAALRYRIGGNAVMADQIRHLHELSLLANMSIRVIPFTSDGHIGLETDSFVLFEFPQHLNPALTQPPVVYIEGYAGTLYLDKPTEIEVYRQALSDIAAVALNEAESRALLQKIEQEYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZQ8</accession>
    <name>A0A231GZQ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42094">
        <property type="protein sequence ID" value="OXR42094"/>
        <property type="gene ID" value="B7C42_05693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="26196" checksum="A9EA1B683A31B788" modified="2017-10-25" version="1">MKRETQNLLLVLVGVAILRTAIDGSYLRYVKPGLHPFLLVSGTGFVVFAAISIVRDIRRSGISPDDGHGRAQWLLLTPAAALLLINPPALGADSVATSSRVQVAAPVADEPELRPFPPLPDEPAPALTIYDLANRALYDATHSLDGREITVSGFVLAPQGESSTRQDVSTIDLARVLITCCVADARYISVHLSGIGEPIAADTWLQVQGTVEPGSAGRDPDKIPTLRVTDVQRIPAPDHGYEHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZU1</accession>
    <name>A0A231GZU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone Hsp31 and glyoxalase 3</fullName>
            <ecNumber evidence="2">4.2.1.130</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hchA</name>
        <name evidence="2" type="ORF">B7C42_05725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42126">
        <property type="protein sequence ID" value="OXR42126"/>
        <property type="gene ID" value="B7C42_05725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="25475" checksum="6637F76B671AA30D" modified="2017-10-25" version="1">MPKVLFVISAADRWTLNDGEIHPSGYWAEEVAVPHRIFSEAGWDITLATPGGKAPTLDRLSLGISGGLPWKRRDIKQYLDSIDSALAHPVALDTVDPDAYDVVFYPGGHGPMEDLAYDATSGALLTERLASGKPLALLCHDPAAILAATPPDGHSPFAGYRMTGLSNREELLNRFAKKAPWLLEDKLKETGVEYSKALLPLRPHVVVDRNLYTGQNPQSSEKLAQRLLADVGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H025</accession>
    <name>A0A231H025_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor NicS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nicS</name>
        <name evidence="6" type="ORF">B7C42_05798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778508.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42199">
        <property type="protein sequence ID" value="OXR42199"/>
        <property type="gene ID" value="B7C42_05798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="205" mass="22777" checksum="5BAB4345F20BD34F" modified="2017-10-25" version="1">MTSTTAPGQSPGRRVGLREKHKARTRTAIREAAMRLFDQQGYTPTTVEQIAQEADVSHTTFFRYFTSKEQVVISDDLAEEREAAIAALPSGLGHFDLLRALLREIYRISMADPWASNPDRMRLIQSEPALQTAFQIESDRALFGGVAFFADYLGLDPDNPRLRVFVSAARGVLMHIANDSADPRDEGMLTTLLEAVDLLEQGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0D8</accession>
    <name>A0A231H0D8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42221">
        <property type="protein sequence ID" value="OXR42221"/>
        <property type="gene ID" value="B7C42_05820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020378">
        <property type="entry name" value="DUF4186"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13811">
        <property type="entry name" value="DUF4186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="13931" checksum="8488253D4472B3A0" modified="2017-10-25" version="1">MRLDHATLDARLEAIAREPFRAKFHLRAPEVEFVALRGMTVVREHAADLIGKRLAPAHPAKDGKQTPWGGHPVFRAQHATATCCRSCLQRTHGIAKGRELTTPEREYVVDVICRWIEVECARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0I9</accession>
    <name>A0A231H0I9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase</fullName>
            <ecNumber evidence="4">1.14.99.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ncsB3_4</name>
        <name evidence="4" type="ORF">B7C42_05565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.49" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42366">
        <property type="protein sequence ID" value="OXR42366"/>
        <property type="gene ID" value="B7C42_05565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="44366" checksum="1810DF6729199CB2" modified="2017-10-25" version="1">MTNRPAFPDANERPLDTCLRLRKTAPVVEVDFPGGVPAYLALSHRAVEEILAGDNKTFARDPKHWPALYDGSIPADWPFRAIVQGDHLSTKDGADHRRLRGLVGKGFTPARVRALEPRIQAIIDGLLDGVAAAGDPVDLVPAFCDALPMAVISELFGVPESERAQLRQWTLTSLSQDISAEEAFSTQVALRGYLYELVERKQREPGDDLTSDLVRARDEGDRLTTDELVAVLWLMLIAGHETTVYLLGNAVVALGRHPDQLALVKAEDRWADVVEETLRYRHSVMMTSFRFTLADVTIDGVPIPKGNAVGVVYQATGVDTAYHGETADEFDITRPPRPHLGFGHGPRYCIGAPLARLEGRLGLSSLYRRFPDLTLAVDPAEIPYTPSFFTVGPLSVPVHPGADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0X4</accession>
    <name>A0A231H0X4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit E</fullName>
            <ecNumber evidence="8">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nuoE</name>
        <name evidence="8" type="ORF">B7C42_05272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042442.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42496">
        <property type="protein sequence ID" value="OXR42496"/>
        <property type="gene ID" value="B7C42_05272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="27166" checksum="EA3068B42A238362" modified="2017-10-25" version="1">MTAEPIPATATGRDPILLQLSQRPVPYPPQVQENLRAEAREIIDRYPQSRSALLPLLHLVQSVEGYVSGTGIAFCAEQLGLTDAEVTAVATFYSMYRRTPTGDYHVGVCTNTLCAVMGGDEILAALARHLEIAPGETTADATITLEHLECNAACDYAPVVMVNWEFFDNQTPESARALADALRSGREVTGTRSGAPLCSFRDTARILAGFPDRRPDANEGAPGDPTLAGLRVATEPSTPAAPQRDSDDEQGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H147</accession>
    <name>A0A231H147_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42583">
        <property type="protein sequence ID" value="OXR42583"/>
        <property type="gene ID" value="B7C42_05360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="38242" checksum="4F3FFFB4C24DED09" modified="2017-10-25" version="1">MSDNERNTPAPVPVAPTGWRGHWHRFRHSPYLPATVLVFILAIAAGLFAGSYTYILANPTPHRIPVAVVDAGSAVPAPDQRFLDTMNQALNGSLHPLHYDTPAEAREAVESQRVFAILDVRTAERIPVEISGASGSSVAQVVVTAAAEASRQTRIPIAVTDINPLQPGDPRGLAIFYITLAAVIIGFVGAIQLGVHAGALSAVQRIAFTVAYALLGGFAIAAVVDWWLGALTLPFPQSWGILTFTMFTSGMIFSMFSALFGRWAMIPTWGVMVLLGNPSSGGAVSWPLLPSVLGAIGRWLPPGASVNAQHTAVYFSGHQHIFPYLVLAGWALVASAVFWVWRDRHAGARDPDPADSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H185</accession>
    <name>A0A231H185_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42602">
        <property type="protein sequence ID" value="OXR42602"/>
        <property type="gene ID" value="B7C42_05379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="135"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="23893" checksum="9B41178AB50098DB" modified="2017-10-25" version="1">MDSMTSAEPAPESVPTVRHSPADIVLTSERRDVPVDRATAAARRVIDALLRTDRANANLDRVAEELDSIADHLEQHAPVVAERLIDMWRGEGVTRHDPVTGPENAIAPPLALTGRADGSVDGVVTLTLPYQGPPGHVHGGVAALLLDHTLGVANAWSGRSGATAQLNVRYHRPTPLFEPLTVSGRMVSEDGRKINSTGAVHTADGTLCVSVEGLFIDKRVPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1X2</accession>
    <name>A0A231H1X2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase FadD13</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42843">
        <property type="protein sequence ID" value="OXR42843"/>
        <property type="gene ID" value="B7C42_05181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="466"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="550" mass="59417" checksum="E0FAB0E2A7A8ADD5" modified="2017-10-25" version="1">MTRAADPQAIAARITADLTGPGGPFEMVVEEVLGAPIPVMRNRRRSMAELFHAGTAWGDHDYLVTPDRRITFAEHGAAATALARALADRYGVGKGDRVGILAANTPEWVTTFWAAQVLGAIPVGYNAWWAPREIAYGLEHTRPTVVVADAKRAALLAEVGSDIPVLTMESDLPRLIADHPGPAPEVSIAEDDPAVILYTSGTSGRPKGVVHTQRNLLAVCDYHRFTDAMAAAFRGRQLGPGPSDRRFLLTSPLFHIASLHNLIVPRLATGATVVINTGSFDPQRVLSLMERERVTNWGAVPTMVSRMLEHDLSRYDLSSLVAFSLNAAPSSPAFHQRLRRELPMAEVALTTSYGLTESGTAATVATPPVLAAHPDTVGMPIIGVSIEIRDADNRALPDGEEGEICVRSPYVMLGYWNDPAATATAIDAERWLHTGDFGVLEEGRLRLSGRRSDLVLRGGENVYPTEIENVLDEHPAVLESAVLGVPHADLGQEVAAVVVVADPATVTEDELRAFTAERLAYFKVPARWVITAQPLPRNATGKVVRREIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Y5</accession>
    <name>A0A231H1Y5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780206.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42837">
        <property type="protein sequence ID" value="OXR42837"/>
        <property type="gene ID" value="B7C42_05175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15089" checksum="0C51A0EBFADBF75F" modified="2017-10-25" version="1">MADHPARAAGLASQHAVRTKDRATWLTLFAPDAVVEDPIGRSPYDPAGNGHRGRDAIAAFWDTAIADSDIAFRMHDSYACGAEVAFVGTITSVRREITVEVDGVFTYRVDADGRIAALRAYWELDRARRTPSEPAETAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H203</accession>
    <name>A0A231H203_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780167.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42871">
        <property type="protein sequence ID" value="OXR42871"/>
        <property type="gene ID" value="B7C42_05209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="15457" checksum="59EB7B11E6DDDF89" modified="2017-10-25" version="1">MTQIAAAHAVSTAAPADFFAVWADMAAWPEWNADTEWVRLDGPFAEGATGTLKPKGGPKVAFVVEKLTDEEFVDVSRLVGARLIFAHRVVRTAAGTEVTVTISMTGPLRRLWSALMGGGLADSVHRDLAALVETAEARRAVPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2C8</accession>
    <name>A0A231H2C8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778450.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42996">
        <property type="protein sequence ID" value="OXR42996"/>
        <property type="gene ID" value="B7C42_04882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15520" checksum="1DBDDC0D3EF24653" modified="2017-10-25" version="1">MPMIHLTVPAGVLTGPTRDELLRSLPKTLLKWEGAPDTAFFRAQAWCRVEDVAAGGFAALEDDLPRFRVDVTVPEGGLSQRRKAGLVTEVTEQVLTAAGLTDGDAWRVWVLIHEQPEGTWGAAGSIVRFKELASLAQGQRDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2H5</accession>
    <name>A0A231H2H5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="2">1.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acr1_4</name>
        <name evidence="2" type="ORF">B7C42_04928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43042">
        <property type="protein sequence ID" value="OXR43042"/>
        <property type="gene ID" value="B7C42_04928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="30942" checksum="57A973CE51F3A141" modified="2017-10-25" version="1">MTDTASPGRPLAERVATRLLYPTSRPRDTALREAVSGRVVLVTGASHGIGKVTAAKFAAAGAVVVMVARSAAELDAAADEITASGGIAHTYSADLTDMDAVDELARDILATHGRVDVVINNAGRSIRRSIDQSYDRFHDFTRTIDINYLGPVRLLLALLPAMRERGRGHIVNISTWGLRMPPVPRWAAYGASKAAFDQWLRTVATEVAADGVTTTSIYMPLVHTRMSAPTDFGSMPGLTAAEAADLVCHAVVAKPVEISPWWSGPLQAWTDLTRGPMQRLMALGFRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2W1</accession>
    <name>A0A231H2W1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent hydroxymycolic acid dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd2_5</name>
        <name evidence="2" type="ORF">B7C42_04604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43182">
        <property type="protein sequence ID" value="OXR43182"/>
        <property type="gene ID" value="B7C42_04604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="304" mass="33156" checksum="67C61FF8AC71F1A3" modified="2017-10-25" version="1">MPAPIPQFGVFLPQFNTSPDAVIATARTAEDAGFDSFWLMDHLYAPAAPPVDVPDSWILLTAIATATATIRLGHLVGCAPLRHPAVLAKMAATLDRISGGRLDLGLGWGSIEEEFARFGIEAGSPRVRSQRLAETLEILALMFTGERFDYAGKHFRLRDAWGLPVPAQDRIPFHIGGGGPTLTMPLVAEYADWWNCVAGARERMDQLAPLRGSARISAQYPVGLVHPGDDPEAVRAKLLRRMPESSWGPPVVGTPAELVDYFARERARGVDLFILRFHNHAPARTLDLFATQVAAPLRRAAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H326</accession>
    <name>A0A231H326_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carnitinyl-CoA dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">caiD_5</name>
        <name evidence="7" type="ORF">B7C42_04693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.149" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43271">
        <property type="protein sequence ID" value="OXR43271"/>
        <property type="gene ID" value="B7C42_04693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLP1_add_C" evidence="6">
        <location>
            <begin position="431"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="795" mass="84533" checksum="746E97FA5DC18089" modified="2017-10-25" version="1">MYSGMTDLSELDSRTPVLVGVGQSSERIDDPGYRGLSAVELAAEAAAEALADTGADTVALGAAIETVAAVRQFEISTPGARAPLGKSDNYPRSVARRIGADPRKAILEVSGGQSPQHLVTEMAATIARGDLEVALVCGSEAISTTRHLAKSADKPDFSETVGGELEDRGYGLEGLSSRHLAMHGLTNAPSQYALFENARRARLKQSRADYALSMGRLFAPFSAVAAANPHAAAPVQRDAHELATPTERNRFISEPYPRFLVARDQVNQGAAVLLMSVAAARRLGVPEERWVFLHGHADLREPALMDREDLSCAPASVMAVRHALEIAGIELDEIATFDLYSCFPIAVSNICDGLDLAPDDPRGLTLTGGLPFFGGAGNNYSMHAIAETVNRLRARPGTFGLVGANGGTLSKYSVGIYSTAPAPWRADRSAELQADIDAWPTPEQAAAADGWATIETYTVKHGHNGERTGVVIGRLEADARRFVAMTQQGDEEILGRLGTGEPIGTRVYVRSFGFGNRVTTDQARMDELFPPRPKVLRENYEHVSVRRDGHLLEITINRPEVRNSLHPPANEELDEIFDAYFADPDLWVAILTGAGDKAFSAGNDLVYSASGKSVWVPKNGFAGLTSRRDMTKPVIAAVNGFAMGGGCEIALACHLIVADETATFALSEVKVGLAAGAGGLVRLPRAIPAKLANEMILTGKRITAAEAHSYGLVNHVVAPGTAMAGARALAAEILDGSPTSVRASLQIMSETAGIADTIDAVTHLSPALDALLLSEDSVEGMTAFAQKRRPVWRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H330</accession>
    <name>A0A231H330_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase MhqP</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mhqP_4</name>
        <name evidence="6" type="ORF">B7C42_04687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43265">
        <property type="protein sequence ID" value="OXR43265"/>
        <property type="gene ID" value="B7C42_04687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="18508" checksum="97DF21923A2BB16C" modified="2017-10-25" version="1">MTALHRTSYDRSADIAAIALRATLGPMLIAHGWNKIAGPGGIEGTTRWFGSLGLRPAAVHARMAAAGEIAAGTGLVLGLANPLPAAATVGLMSVAAATDHRGKGFFVFKGGWEYVGVVAGTAVALAGLGHGRFSIDGLRGRRRSGLRPALAAAALGSAAAGALLTLCYRPAPPDDAAADVTTADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H389</accession>
    <name>A0A231H389_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1,2-epoxyphenylacetyl-CoA isomerase</fullName>
            <ecNumber evidence="6">5.3.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">paaG_3</name>
        <name evidence="6" type="ORF">B7C42_04753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.18" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43330">
        <property type="protein sequence ID" value="OXR43330"/>
        <property type="gene ID" value="B7C42_04753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="27996" checksum="21F841415FA77BBE" modified="2017-10-25" version="1">MQTVEVERHDGVVTVVMSRPEKKNAGSPAMWRELAETFTEIERTPGDRVMVLTGAGGDFCSGADLDGISGDALDYMKRASHAAAALSALTIPTIAKVDGVAVGAGWNLALGCDLVVATDRARFSQIFIRRALSLDFGGSWLLPRLVGLQKAKELAFFGEILSAAEAYELGLVTRIVAPDELDSTVESMARQLVHAPAQALSLTKQLLDAAADGGSIEAALQRENHVQANNIVGADAAEARAAFLEKRAALFYRPDSQPAPTAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H395</accession>
    <name>A0A231H395_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909266.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43341">
        <property type="protein sequence ID" value="OXR43341"/>
        <property type="gene ID" value="B7C42_04764"/>
    </dbReference>
    <dbReference type="GeneID" id="66723360"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="7"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="34433" checksum="2EC8D60142B5F9B6" modified="2017-10-25" version="1">MIAWNSLRIPVMAAPMFIVSNLDLVIASCRAGIIGAFPSANPRRPETLDTWLRAIREAEKTTLDSGREFAPFCVNMLASAALDKRARDEALATVRKHRAPLILTNMGDPREVVDAAHEWGGMVFHDVTTIRHAEKAIEAGVDGLMLVCAGAGGHAGTLSPFSFLPKVRSIFDGRIMLAGGIADGNGIAAALALGADIVVMGTRFIATAESGTVEDHKQMLVTSESEDVLFTDAIAGLPASFLEPSIVKAGLDPRNLPRPTGKHRPNLPEGVKPWKSVWSAGHSTGLINDVPTVAAVVDRLAVELSAARVPGDWRKRLSDKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3A1</accession>
    <name>A0A231H3A1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009561.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43298">
        <property type="protein sequence ID" value="OXR43298"/>
        <property type="gene ID" value="B7C42_04720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15451" checksum="2129C3587461B52F" modified="2017-10-25" version="1">MSDVRATTLPADAVHITTNSDTEPFWQYAKEGKLVALQCGSCGHFRMPPTPFCPECQSTEKNWKRLSGRGSVYSYAVIHGFPGIPDITLVGAVVSLEGAGDARLVTNIVDVDPSEVQIGMELEVTFSPIADGWQLPVFRPAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H480</accession>
    <name>A0A231H480_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43709">
        <property type="protein sequence ID" value="OXR43709"/>
        <property type="gene ID" value="B7C42_03944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="64"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="35606" checksum="908E7354172A219E" modified="2017-10-25" version="1">MPEGGDRSGSSNLVDMIESGSDSETVPPSTESSDRTHPPRPHLAAEVATQPDDWVWAAEVAAEHRTLLPDPGERVAVVGCGTSYFMASAIAELRESAGHGLTDAWPASAVRTGRAYDRYLVICRSGTTTEVVDAMRAMPAAAARTVICSSPGTPVLELADPIPVDAVDERSVVQTRFATTALAILRWHLGEDLAPAIEQARAVLAESAESSAPAALRQAEQITFVGTGFAAALAHEAGLKLRESCRAWTEGYLANEYRHGPISIAAPGRAVWALGPVVAGLRDEILATGAHFEHRDIDPMAELVRVHRLCLLRAADLGVDPDHPRGLRRSVILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4L2</accession>
    <name>A0A231H4L2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3,6-diketocamphane 1,6 monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43656">
        <property type="protein sequence ID" value="OXR43656"/>
        <property type="gene ID" value="B7C42_04524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="422" mass="47133" checksum="8B8516A96CBADEF6" modified="2017-10-25" version="1">MKVTYFQQVPYRKLPGDFEQRYESVITTPYFDLTDSDAVAGDFRAALDELMFAARLGFDGLAVTEHGQSSYDMAPNPNLIEAALAYATEVEQIDTAIYPVGRSLGKSREPIRAAEELAMIDCMSRGRLVSGFPVGLAYDANINNGVAPAETRLRFDENLDLVLKAWAAREPFAWNGRFSQHPAVNLWPRPIQQDPLPPVWITGIGNPRTMQMTLEREFGFNYFGWFGLKVAGRRIFDRFWEQVENAGKEANPYRLGFMQTICVADTDAKAEALYAEHAEYFFRKGIGSIPMERLALPGGIDIRGVEAIMRDPSDFGIYGKMRTASFAELVEAGSVVCGSPDTVVEQLTAHAREYRIGNLHAMLQFGSMPHELAKENISLFASDVMPRLQRIWDDEGYAHHWWPERLGGTPLTSNATSIGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Z9</accession>
    <name>A0A231H4Z9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43796">
        <property type="protein sequence ID" value="OXR43796"/>
        <property type="gene ID" value="B7C42_04031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011257935" evidence="2">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="10583" checksum="E3C6A7B17E9175DE" modified="2017-10-25" version="1">MTRTRAVRKSSFTILAAVAIGMAPVAVAAASPESPSGAGTSAVTVEPAGPRVSGAQNRAAAAVADSVAATAVSPRAEQVSSLLDLLPTPLNCLLSTGYALLCLGVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5U9</accession>
    <name>A0A231H5U9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbpA_2</name>
        <name evidence="3" type="ORF">B7C42_03760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44200">
        <property type="protein sequence ID" value="OXR44200"/>
        <property type="gene ID" value="B7C42_03760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MecA_N" evidence="2">
        <location>
            <begin position="58"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="340"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="613" mass="62425" checksum="5F2F5AF7FF84B91A" modified="2017-10-25" version="1">MRPTGGPRAAADYPAAAARGGSVGRVRTGSKLFALLAAPILAAAACSGDSSADRLDRSVHTFADALSHGDPAAAAAVTGDPARATTTLGTLFDSLGKKVRVDVRAVNRSDHHATFDLATTWTFGAAGNQWTYTTTGTADESGDDWKVRWNPATVAPGLETGPLSYDTVTPQPAARVLDRDGAELMTQQVVTLVQLAPGADPNAVAAVLGPIDPSISAASLRQDMDKAQGKPVTAIALRAGDLAPVQDRLAALPNVTLAQQTRLLTADKALTSPALSGVSDLWQHSTDAAAGWAVRAQATDGVHTVGGQDPKPVADIRTTLDTGMLRRAEAALAPIPTPAAMVVLRPSTGDVLAVGQNAPADAQGPIALTGLYPPGSTFKTVTVSAALQAGHVTADTMVACPGTENIEGRQIPNDNNFDLGTVPLHTAFARSCNTTMGRLAVNLPPDGLTRAAAQLGLGVDFTAPGMTTVTGKVPTADTSALRVEEGIGQGRVTASPFGMALVAATVAHGAVPAPTIVAGSPGKADRTPDPVPAPVLDQVKSMMRETITNGTATSLADIPGMLGKTGTAEYIDDAHAHGWFVGIDGDLALAVFVGDAGSSVPAVEAAGRFLRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6N9</accession>
    <name>A0A231H6N9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">purL</name>
        <name evidence="10" type="ORF">B7C42_03374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776013.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44584">
        <property type="protein sequence ID" value="OXR44584"/>
        <property type="gene ID" value="B7C42_03374"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="9">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="100"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="215"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="462"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="594"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="764" mass="81065" checksum="53544F18314FFD7E" modified="2017-10-25" version="1">MTVHVDTVSAAAATPDTPQPYKELGLKDDEYARIRDILGRRPTDAELAMYSVMWSEHCSYKSSKVHLRYFGQTTTDEMRASMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPIAVMDQLRFGAADHPDTRRVVDGVVRGVGGYGNSLGLPNVGGETVFDASYQGNPLVNALCAGVMRVEDLHLAFASGTGNKIVLFGARTGLDGIGGVSVLASDTFSGDESASGRKKLPSVQVGDPFAEKVLIECCLELYHAGLVVGIQDLGGAGLSCATSELAAAGDGGMRIDLDKVPLRAANMTPAEVLSSESQERMCAVVTPDNVEAFMAVCHKWDVLATVIGEVTDGDRLVVKWHGETVVDVPPRTVAHEGPVYERPVQRPEEQDALVADTTAGLARPKSGDELRATLLKLISSPQLCSRKWIVEQYDRYVRGNTVLAEHADAGVIRIDEESGRGIALATDASGRYTKLDPYTGAQLALAEAYRNVASTGATPKAVTNCLNFGSPEDPGVMWQFQQAVRGLADGCVALGIPVTGGNVSFYNQTGQTAILPTPVVGVLGVIDDVHRRIPTGFGTEPGETLILLGETRDEFDGSIWSQVEHDHLGGVPPRVDFAREQLLAEVLTAGSRDGMISAAHDLSEGGLAQAVVEGALAGETGVRILLPEGDDPFVTLFSESAGRVLVAVPRSEETRFTKMCTARELPWVRIGVVDQGSDSVEVQGQFSITMDELRTAHEGTLPALFGATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Q4</accession>
    <name>A0A231H6Q4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775941.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44525">
        <property type="protein sequence ID" value="OXR44525"/>
        <property type="gene ID" value="B7C42_03314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="36267" checksum="8B0D7DA08EB02705" modified="2017-10-25" version="1">MSDNATDIAVVGFAHAPHVRETYGTTNGVEMLVPCFRQLYDKLGIGVSDIDFWCSGSSDYLAGRAFSFISAIDSIGAVPPINESHVEMDAAWALYEAWVKLRSGQAETALVYGFGKPSAGTLRQVLTMQMDPYLVAPLWPDAVSVAGLQARAGLDAGNWTERDMAAVSAADDAEIEKRLAAPYVANPLREHDIAPITDGAAAIVLARGDKARELCERPAWLTGMAHRIDTPMFGARDLTTSPSTAAAAKAVLGGDASGFDVAELHATYSHEQLILKQAIGLSESTRINPSGGALAGNPMFAAGLERIGYAANEIMNGTAERALAHATSGPALQQNLVAILEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6S3</accession>
    <name>A0A231H6S3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron-dependent extradiol dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hsaC_3</name>
        <name evidence="9" type="ORF">B7C42_03269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.25" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44480">
        <property type="protein sequence ID" value="OXR44480"/>
        <property type="gene ID" value="B7C42_03269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047071">
        <property type="term" value="F:3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 7 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="142"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="33500" checksum="EFC2E7805DD057E2" modified="2017-10-25" version="1">MSIRALGYMRIEATDVAAWREYGLKVLGMMEADGPNPDALYLRMDDFPARLVIVPGEKDRLQVSGWEVTDAPGLQRLRETLAKADVAFEEGTKDELAERRVEGMIRFQDPSGNTLEAFYGAQYLARRFVSPYGHKFVTAEQGLGHVVLTCTDDAEAQAFYQDVLGFRLRDSMRLPPQVVGRPADGDPAWLRFYGCNPRHHALAFLPLPNPTGIVHLMVEVENSDDVGLCLDRALRKKVKMSATLGRHINDKMLSFYMKTPGGFDIEFGCEGLEVDDHSWIARESTAVSLWGHDFTVGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Z6</accession>
    <name>A0A231H6Z6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44694">
        <property type="protein sequence ID" value="OXR44694"/>
        <property type="gene ID" value="B7C42_03488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="124"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="383" mass="41346" checksum="7901C0F59758495F" modified="2017-10-25" version="1">MAGTEIVAAARRAALAAAGLVGLRWVVRAAWRIPVEMGASAAAIAPLATRSASYRDRQFHNTEPSSQISPGSGASLLLSALTRRDVGRPPAPIPLAGAEHPEEAAELAVTWFGHATALIEVDGYRILTDPVWSERVSPSPLVGPARLHPVPAPLSSLPALDAVVISHDHYDHLDRETVRALVAAQDAPFVVPIGIGAHLRKWQVPEARIIELDWNTSTSIARPGRGELTVTCTEARHFSGRGFTRNTTLWASWVFAGPRRRAYFGGDTGYTKAFAEIGATYGPFDLTLLPIGAYDVHWPDVHMNPEEAVRAHADVCVGDAEYGILVPIHWATFNLAFHGWSEPVRRLVAAARAAGTRVVVPLPGGRIDTDAVSPQLSWWEDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7B0</accession>
    <name>A0A231H7B0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">plsC_3</name>
        <name evidence="5" type="ORF">B7C42_03431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="3">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44637">
        <property type="protein sequence ID" value="OXR44637"/>
        <property type="gene ID" value="B7C42_03431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="4">
        <location>
            <begin position="306"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="52009" checksum="0C44BE3210E37B4D" modified="2017-10-25" version="1">MNLSEAISAIRTGPQGPRVAAVFDFGGTVVAGFAPAAAPLRLLRGRDSRRALTDTLLYSIRGSRTEGEYERFLQRVARVWVGRSEQELTELGEQLFRSTVYGHVYPEAWQLIREHEAAGHTVVIVTSLTRFQVLPVARELGVDHVLYTAMATADGVLTGFTEGKPLWRTEKAAAVRRFAAEHDIDPADSYAYADAAPDVPLLETVGHPVAVNPGPRMSMTAGERDWPTLAFKPRDPAGVTDFARTAVGFTGLLSGAAFGVASRAVTRRHRAMADAMIATAADATLRTTGVRVRVVGAEHARQPRPAVFLFNHQSQFDMVVLAAVLRSGFTAVVKKEVTTNPVFGPLLRFAEATFIDRSDTTGAKAALKPVVDTLRGGLSLVVAPEGTRSMTPRIGPFKKGAFHIAIEAGVPIIPLVIRNAGEIAWRNSAIVRKGTVDVAVLAPIDVSGWDPQDMDADIARVRQLFVDTLRDWPVDAAVEAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7G3</accession>
    <name>A0A231H7G3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051024228.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44666">
        <property type="protein sequence ID" value="OXR44666"/>
        <property type="gene ID" value="B7C42_03460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="16725" checksum="05A04D5DB209C344" modified="2017-10-25" version="1">MWCHVSFASVTTPSDIRALAGELSLAVVRLTRHLRGRRADAQISLTQLSALATLARDGAMTPGVLAAKERVQPPSMTRVIASLSELQLVKRDPHPTDGRQVIVSLSDAGKALIQDENNAREAWMFDQLSGLTPDQLRVLDDAVSIMKQLVADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7X8</accession>
    <name>A0A231H7X8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44857">
        <property type="protein sequence ID" value="OXR44857"/>
        <property type="gene ID" value="B7C42_02811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="10170" checksum="745829A98C01D3A0" modified="2017-10-25" version="1">MRASNWMAHALFTDFAALPARERNSVRWMFLGSEPRELFLDWETQARAAVESSRLDVGTNPGDRAGLALVEELSAAAGEFRQWSTRGRDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Z8</accession>
    <name>A0A231H7Z8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44920">
        <property type="protein sequence ID" value="OXR44920"/>
        <property type="gene ID" value="B7C42_02876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="53" mass="5733" checksum="7608E6BEF07375C3" modified="2017-10-25" version="1">MGVFGEIFPGKKLTDESGGDSDGQQHRPRLDLDLDAGVIRLSSTPRSDEESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H865</accession>
    <name>A0A231H865_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lutC_2</name>
        <name evidence="2" type="ORF">B7C42_02947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784270.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44990">
        <property type="protein sequence ID" value="OXR44990"/>
        <property type="gene ID" value="B7C42_02947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="45"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23361" checksum="3B468B98421F3546" modified="2017-10-25" version="1">MNARETILRRVREAIGEPAEAVTVPRDYLRTAPGVDPDDRGAILELFEQRLERYGAQVHRTTLAGVAATVDRELRNASARVVLTPPGLPDIWTALWADRSEHRVVTDDPPLTTRELDEVDAVVTTCAAAIAQSGTIVLDGDAGQGRRAPTLVPDCHVCVVHAEQVKTALPEVVPRLDPRRPTTWISGPSATVDIEMTRVQGVHGPRRLIVILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H880</accession>
    <name>A0A231H880_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allophanate hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atzF</name>
        <name evidence="2" type="ORF">B7C42_02348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45223">
        <property type="protein sequence ID" value="OXR45223"/>
        <property type="gene ID" value="B7C42_02348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004039">
        <property type="term" value="F:allophanate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014085">
        <property type="entry name" value="Allophanate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02713">
        <property type="entry name" value="allophanate_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="530" mass="54502" checksum="BA534A9045DCAC2E" modified="2017-10-25" version="1">MSIWIQRSDDPGPHGTGPLAGLRVAVKDNVDVAGLPTTAGCPDYAYLPDRDAPAVAALRAAGAVVVGKTNMDQFATGLVGTRSPYGPVPDSRRPAFISGGSSSGSAVAVATGAADIAIGTDTAGSGRVPAALQGIVGIKPTVGVVSTEGVVPACRSYDCVTIFAADPARADQAMGVMAAGAPGRAWPADTRLAAPPRPTVAIFADLPELDPVWRAAFDRTVTALRQRGATIVEIDPAPFLAAARLLYDGALVAERYAAVGEFIETHPNAVDPTVASIIRAAREIPAHRLVTDRAELERLRALAMDSLGDADALLAPTTPMHPTIAQVEADPIGVNSRMGTYTNFCNLFDLCAVAVPAGMAGESCFGITVFARPFEDAVALDIAVSITGDAEITRPWPLAVAPVCELIVFGAHLRGQPLEHQLHALGARWAGPVRTAAAYRLAALDTTPPKPAVTRCEGGVSVAGERWLLAPAALGRFLAALPAPMQLGAVELADGTWHTAFGCDGSAAADGKDISEYGDWRAALAAGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H894</accession>
    <name>A0A231H894_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">moaC2</name>
        <name evidence="5" type="synonym">moaC</name>
        <name evidence="8" type="ORF">B7C42_03015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45058">
        <property type="protein sequence ID" value="OXR45058"/>
        <property type="gene ID" value="B7C42_03015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="7">
        <location>
            <begin position="231"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="384" mass="39082" checksum="C453004E08F1AF44" modified="2017-10-25" version="1">MNELPDAAALSHVDAEGRARMVDVSAKAETARVAVAAGLLRTTPEVVALVRADDLPKADVLSTARIAGISGAKKTSELIPLCHQLALSSVDVRFGFAESAITIEARAKTKGPTGVEMEALTAVAIAGLTLHDMVKAVDPAAVLDGVRLLTKDGGKRGHWERPDRDRTEDAAISGAGTSPQPQAAPTADTGHRAATEDRPVHHHTESPRGAHSPADPRHSDATPAGEGSRTAVVVVASTGVAAGTRVDKTGPVLTDWLAGLGFSVRGPLVYADAEIEAGLRDVLDGSPGLVITTGGTGASPSDATPEATLAVLDRELPGVAELIRQRGTAAFPLAALSRGVAGLSGTTVVVNLPGSPGGVRDGIAVLEPLLDHLLAQVAGGGRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8H5</accession>
    <name>A0A231H8H5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory protein AsnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">asnC_2</name>
        <name evidence="6" type="ORF">B7C42_03106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45149">
        <property type="protein sequence ID" value="OXR45149"/>
        <property type="gene ID" value="B7C42_03106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="36349" checksum="AF8D81041CF2F9A3" modified="2017-10-25" version="1">MTHEETTSSTGSTSTTAQGFPQDALDDVDRTLVERLRADGRETNRALAQALGINEVTVAARLRRMEQNSIMRVVAVTDMRIFGHREFAFACLRVSGEPATKVGSAVATLPEAVAVTISTGRYDVIVPILGRDHKHLAQLFNSSLARVAGVEEVRGLLVLDVLKFDSKWALLSADPGTTPDAQPGDEVDELDLAIIEKLQIDARRSNRAIATDLGVSEGTIRSRIKRLTAGRVIRIQAVSDVVAFGIGAHAYVGITCHGGRADEVAVALAEREDVAQLSRTLGEFDFMAVIVAPTRERLVSALIDEISQIPGLWRTETFETYATTKHTYAWSWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8K2</accession>
    <name>A0A231H8K2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45102">
        <property type="protein sequence ID" value="OXR45102"/>
        <property type="gene ID" value="B7C42_03059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="5562" checksum="ACD0F337666EA77F" modified="2017-10-25" version="1">MYRNVFRRLTGRRLSEFERRNLRSCRPAAPVHTAALGAHPGRRPGAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8L9</accession>
    <name>A0A231H8L9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA</fullName>
            <ecNumber evidence="4">3.1.4.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cpdA_2</name>
        <name evidence="4" type="ORF">B7C42_02320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.53" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45195">
        <property type="protein sequence ID" value="OXR45195"/>
        <property type="gene ID" value="B7C42_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601735" evidence="2">
        <location>
            <begin position="34"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="157"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="469" mass="50828" checksum="CF9969E89676744E" modified="2017-10-25" version="1">MTCCGPNRRRLLTALAVAAATPIVLPGSARAQADSLRATDLEVVTLTDTSAIITWTTLAADASGAPVPVEAGTEIRVAPADSAGPARTVPVTRTDRTPYHYAQIDGLEPGRRYRFEAWSDGVRAVPAPELVTHLPGAPECSGEFTTLVAPPGRLLRTLALCNDVHIGEETSGIIAAGLPPGVRQEPGLPPYPEVMLAAVLDDLRRPDRGADHLILAGDLTAEATPEQTRAVRNRLDAWGIEGRDWFAARGNHDRPHTGADYAACPAVTADHYDCWGESFLPPAQSTEHRLGGLRLIGLDTTELDGSGGSIGPEQFDRLRESLRRDPDRPTVVFGHHPVTAESGLTNLAGPNFVLNRSDALTLQQLYQSTPGVFFHHAGHTHRNRRTRPDIPLRVEFLEVGAVKEYPGGYTLLRLYEGGYMVNFYKTRTPDARRWSTRSRAEYLGLMPEYTLGSTADRNHVVLGDLSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8R5</accession>
    <name>A0A231H8R5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator AcrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acrR_4</name>
        <name evidence="5" type="ORF">B7C42_02380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776752.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45255">
        <property type="protein sequence ID" value="OXR45255"/>
        <property type="gene ID" value="B7C42_02380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="25342" checksum="4B31D5CBB48A2627" modified="2017-10-25" version="1">MPSDNSTPVRAADAAEFRLAVVDHALRLFAEQGYEATTVDEIAEAAGISRRTFFRQFRSKEDVVFADHEEQLARAKAYLTAAQGDPWDAVREAVVGIFERFTETRELAARRYRVVRQASALRDREIVTVFRYERLFTDYLRDRLPEVPDLALIQFSAAVTATHNYLLRRMVRGRSEASAADLRAAVRAIAPPGPAPDPAELVVAVFPRAMPARQVADLLADRLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8V3</accession>
    <name>A0A231H8V3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD-linked oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45250">
        <property type="protein sequence ID" value="OXR45250"/>
        <property type="gene ID" value="B7C42_02375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="452" mass="47446" checksum="711107057E63A702" modified="2017-10-25" version="1">MDIAALADRLPDGTVVTDPDILAGYRHDRALDPQAGMPAALVRPLITEQVATVVGWAHEHRVPLVPRGAGTGLSGGATAQDGALLVSTERMREITVDPVTRTAVTQPGLLNAEVKRAAAEHGLWYPPDPSSFEICSIGGNAATNAGGLCCVKYGVTTDYILGMEVVLADGTVVRLGGPRLKDSAGLSLTKLFVGSEGTLGIITELTLRLLPAQPQQSTVVATFSTLTAATAAIEAVAARLRPSMLEFMDSVAINAVEDEMRMGLDREAAAMLVARSDAPGEFRAREAAIIAEACESAGAAEVFRTEDPEEGEAFCAARRFAIPAVERKGPLLLEDVGVPLPRLGDLVTGIAEIAERREVLISVIAHAGDGNTHPLIVYNPADADETARAHQAFGEIMDLAIALGGTITGEHGVGRLKKAWLPDQVGPEVMDLTRRIKDALDPHGILNPGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8X9</accession>
    <name>A0A231H8X9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45414">
        <property type="protein sequence ID" value="OXR45414"/>
        <property type="gene ID" value="B7C42_02539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15855" checksum="E092F2B4F55CE18C" modified="2017-10-25" version="1">MEQMQLGVDTRITLLIAGLLFVWALLLGVWKYHGMRTSAQGHAHPYVDIAHRAALMYSFAALLLAVFVELSDWPMAVNLVAALIVLGFFAGAIASYCLHGVRRDTTNQFRGDIGLPLRSAMYALIVCEIGGFLVPFTGFVHARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H908</accession>
    <name>A0A231H908_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="9" type="ORF">B7C42_02628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498214.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45503">
        <property type="protein sequence ID" value="OXR45503"/>
        <property type="gene ID" value="B7C42_02628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="187" mass="21032" checksum="014FFBB666621F62" modified="2017-10-25" version="1">MTTAENIQPRLKLRYRAEIKDALNNEFNYANVMQIPGVVKVVVNMGVGDAARDAKLINGAVNDLALITGQKPEIRKARKSIAQFKLREGMPIGARVTLRGDRMWEFLDRLVSIALPRIRDFRGLSPKQFDGNGNYTFGLSEQSMFHEIDVDSIDRPRGMDITVVTTATNDEEGRALLKHLGFPFKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9A1</accession>
    <name>A0A231H9A1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pknJ_3</name>
        <name evidence="6" type="ORF">B7C42_02554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45429">
        <property type="protein sequence ID" value="OXR45429"/>
        <property type="gene ID" value="B7C42_02554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="536" mass="57214" checksum="40DAB22A31EF7CA0" modified="2017-10-25" version="1">MVMSPGTIVGGYRIVRQLGAGGMGTVYLAKHPSLPRMDAIKVLSGELSSNHEFRGRFEREANLAAGLDHPNIVSVYNRGEEHGQLWIAMQYVDGTDASAELARDPHSMTPLRALRIVTEVGKGLDYAHRRGLLHRDVKPANFLLSVPEDDDEERVLLTDFGVAKSTDDATELTQTGSFVATIAYAPPEQLQGMAVDSRADIYSLGCAFYKLITGQNPYPATQPAMVMMGHLYEPPPRATAVNSGLPPAIDHVFARALAKNPADRFASCRELTDAAANALTPGHTPVRTTTSPTYPIQVFDPRPQTDPRTPLPHQTQSGIRTQTGPRPDPDLSRLLEPKPKSRKPLILGGVGALVAVALAAGIGVWATQGNSGGTGPTTTSASAAATTAVTAYTSVPQARAANPAFAGKTITMLDVTGEKTFSVYLGGTSQSKFMEDLGFVYNLQYQKSGDEPSPRPITDQYPELQASADSYILAVRSDPKAGGGGLLGLPYSIASARATVIPLDDPVAVSAMRNWTPTSEQTLLEKLVPILHNQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9I9</accession>
    <name>A0A231H9I9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mbtB_2</name>
        <name evidence="7" type="ORF">B7C42_02643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45518">
        <property type="protein sequence ID" value="OXR45518"/>
        <property type="gene ID" value="B7C42_02643"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1152" mass="123955" checksum="DA85635DA798481B" modified="2017-10-25" version="1">MLGKADVRDIVAAELGIRPDEIGYDDDLVGLGMHSMKLMRLAGRWRKQGHEVRSSELALAPTISAWAELLGATAEPTPTATPATSAEAGAAFADGEEFPLATMQHAYWVGRRQDQQLGGVAAHLYVEFDCRGLDAERMGRAVERLVRRHPQLRVQFTDAGTQRVLPEPLLPVFRVEDLRAAADPDAELERLRQDKSHQRMDVEAGQVVDITLTLLPGDAHRVHVDVDMLAGDALSYRRILDDLAALYDSDADPADAVGYTFREYLDARARHTPDNSAAQAWWEQRLADLPDIPSLPVLAEDERADPSRSIRLHHWFEPEAKAGFDKLAHSHGVTPAVALATVFAEAIARWSARQRFLLNVPLFDREPLHDDIDRVVGDFTNSVLVDVDARAPESMVARAKRLQRELHTCAVHSVYEGLDVLRDLGRLRGGPVTPSVVFTSGLDLGELFSERVTTLFGEPVWILSQGPQVDLDAQVAELGGGLLVNWDVRRDAMPDGVVAAMFAEFRRLLLALAEPGADWNAPLSIELPAQQRAVRERVNDTFTDWQARTLHGDFFDRARRKPEPEALRWRGGACDYGDLADQALAVAAALTDAGVRPGDTVAVVIPKGHRQIPAVLGVLAAGAAYVPIGTGQPPARRDRILARAGARVALTDAALDLPADVTAVELTTALAGRRLERAHASDPDAVAYVLFTSGSTGEPKGVEVSHRAAANTIDALAAYFRLDASARLLGLSSLEFDLSVFDIFAPLALGGALVCVGAEIERDAQAWARLIAEHEVSVLNCAPGLIGMLLDSADAAALRTLRVVVTGGDRVDAELAHRLRALVPDLRFAGLGGATEAAIHSTVCEVTDDFPADRATVPYGTPLANVAMRVVNERGEDCPDWVVGELWIGGTSVADGYRGDPERTAQRFVEYGGLRWYRTGDLARYLPDGTVDFLGRADHQVKIRGYRVELGEVETALTTLPSVQQAVALVTGSGRLAAAVRAGGVTADELRLALRDLLPAHMIPDLIEIVAEIPLTPNGKLDRTAIRRLVEAGAPDAGAAAVAPANEIEAALAYIAAQILGVETVGVETDFFEIGGNSILATTFTAKVRGLLAVEKFGVTAVFGGRTVRRIAAQLQADETTPGRLAQVSRILLELAEVPVPQPDSALAPAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9P0</accession>
    <name>A0A231H9P0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783949.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45575">
        <property type="protein sequence ID" value="OXR45575"/>
        <property type="gene ID" value="B7C42_01867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="28388" checksum="AC75742482189B28" modified="2017-10-25" version="1">MPDPLHFDIHAEVYDRARPPYPAVLWAELQDLGVLRPGIRAIDLGAGSGLATGPLLETGASVDAVEPGRALADRLRRRWPAAVVHVDTVEHVELPTNFYDLAVAATAVHWFDLEVVMPKLHHALRPRGHFAVWRNAFGDPTVSITPFRERVAHIVARRETAEPRRVYGELDTQAWAARLTASEHFETRHIRHFPWSIDMRTDQIHDLFTTFSNWTPAEVDEAARAVDELGGQVTEHYVTPLIVLRSNEFAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Q5</accession>
    <name>A0A231H9Q5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45579">
        <property type="protein sequence ID" value="OXR45579"/>
        <property type="gene ID" value="B7C42_01871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="37"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="32650" checksum="3D5D174B8F99DE98" modified="2017-10-25" version="1">MTASADGRAGIDAGLVARLIARQFPQWSALAVTPVDNDGWDNRTYRLGEDMSVRLPTAAGYAPAVAKESRWLPRLAPSLPIPVPTVLADGEPDLGYPYPWSVRRWIHGETADRAEIGNMTEFAVAAAEFIHALQRCDTTEAPPAGAHSFYRGRPPSHYDAQTRHCLHILDGCVDTAPATVVWEKALATEWDRNPVWFHGDLAPGNLVVDQGKLAAVIDFGTCGIGDPACDLVLAWTMLSGASREAFRRAIDRDSATWDRARGWALWKALLTLAEYQATDHEPASRAQRLVNEILTDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9W6</accession>
    <name>A0A231H9W6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rplR</name>
        <name evidence="9" type="ORF">B7C42_02622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498216.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45497">
        <property type="protein sequence ID" value="OXR45497"/>
        <property type="gene ID" value="B7C42_02622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="14553" checksum="7F59433C541814EC" modified="2017-10-25" version="1">MAQTEAQKAARKPVGKDASTRRRVSKTRRHFRLRKKVLGTAERPRLVVFRSSRHLHAQVIDDSVGKTVASASSIEADVRALDGDKSAKGKKVGELLAARAKAAGVEAVVFDRGGHDYHGRIAALADAAREGGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA23</accession>
    <name>A0A231HA23_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776427.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45567">
        <property type="protein sequence ID" value="OXR45567"/>
        <property type="gene ID" value="B7C42_02692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="15262" checksum="F223E3E18E683E77" modified="2017-10-25" version="1">MKYEAHVTGREGRWWAVTIPALGEDAQTQARRLDDVADEARDYVTLTLDVAPSTIDIEVVIDDLGGVRNINERAARIRAGRAEIERIERENQAEAQALAVELAEQGIPLRDIASLTGYTFQRIGQMTASKAREQAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA30</accession>
    <name>A0A231HA30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase 2</fullName>
            <ecNumber evidence="3">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB_1</name>
        <name evidence="3" type="ORF">B7C42_01993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45701">
        <property type="protein sequence ID" value="OXR45701"/>
        <property type="gene ID" value="B7C42_01993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="29250" checksum="098519A862812827" modified="2017-10-25" version="1">MPDLWSDLLACLDLHSVPAGDGRDTAVFSGPNQSLGYHRIFGGQLLAQFVRAAQLTCPDKSVKSLHALFPREGKPDEALRYRVQVQHQGRSFASVTVLAEQGSRVVATAAISLHAADEGPEQQATAPIGPLLSAEHKAGFDIIPWETRTNVDLDDTGSAAPELEFWMRTPAADATLAPALTGYATDLTLIGTALRPLEGVCQRGNGTAFHSAVTSHTLWFHRPFRTDEWLLLRQDSPVMAQGRCFGRGDVFTENGSLVASFAQEAMVRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA87</accession>
    <name>A0A231HA87_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4822 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45780">
        <property type="protein sequence ID" value="OXR45780"/>
        <property type="gene ID" value="B7C42_02072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032247">
        <property type="entry name" value="DUF4822"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16103">
        <property type="entry name" value="DUF4822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4822" evidence="2">
        <location>
            <begin position="96"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="217" mass="23141" checksum="9B31949403C72803" modified="2017-10-25" version="1">MSDIEYKYWTLYLLFVQAQCRGHRVALRTARPADLEAAAHDREECALYKLASALAAVAAAGLLAACGGHDDTGANPPAPATSSAPAPASAGSPAALLASTPWETTAARDAQGRPVARTDSTVANYVGFAYFDPDGTFTMYNLDDTPKMHGDWSVSPDGRTRTIVAKNAAGQEQFRRVVEIVTLDGTTFTYRVHPDAADRATYYDIVHTPTAHPEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA93</accession>
    <name>A0A231HA93_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45647">
        <property type="protein sequence ID" value="OXR45647"/>
        <property type="gene ID" value="B7C42_01939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041483">
        <property type="entry name" value="TetR_C_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17929">
        <property type="entry name" value="TetR_C_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="203" mass="22061" checksum="5F9400ABF6059DE2" modified="2017-10-25" version="1">MLAEMPVAAVSLNELSRRVGLAKSNVLRYYESREAILLELLDTEARAWLADLDRSTPRSAEGPFRERSGRLVAAVTTTVQARPVLCDLISAQAAVLERNVSTEVVLRHKRSMHDMVNQIAQIVTTVLPELTADDGFQFASTTILAVAAAWPHSTPTEALQAAYDADPTVAELHVTFSDIVTRTLTLTLAGLLSERQAATAAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBM2</accession>
    <name>A0A231HBM2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46219">
        <property type="protein sequence ID" value="OXR46219"/>
        <property type="gene ID" value="B7C42_01185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="21684" checksum="4BC4E2DC888002EC" modified="2017-10-25" version="1">MDHVRIETTAGDAEVEIERGTGDRFLLLLTHGSGGGVEAGDLLAVRDRAVALGGVVARVVQPYRVAGRRAPGSATVQDAAWFEIVAALRARVPGVPLIQGGRSNGARVACRTAVEADARGVLALSFPLHPPGKPEKTRRDELVAASAHVDVVVINGERDPFGIPDPSDAAEVKVVPRQPHSFRAGFDLIAQTVEPWLRRWADGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC35</accession>
    <name>A0A231HC35_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase CwlM</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cwlM</name>
        <name evidence="2" type="ORF">B7C42_01406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036507426.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46440">
        <property type="protein sequence ID" value="OXR46440"/>
        <property type="gene ID" value="B7C42_01406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="252"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="43470" checksum="B7E3E6DD32BC2FE3" modified="2017-10-25" version="1">MHRLRHGDTGPAVAEVRSTLASLGFHPHPHGTDRSGGQGEYWKDSDAVFDRELDSAVRAFQQQRGLLVDGVVGPATYRALKEASYRLGARTLIYQLSAPLYGDDVATLQRRLQDLGFYVHRIDGYFGPHTHDALTAFQREIGLSADGICGPDTLRSLELLGARVTGGNPHRIAEEEVVHRAGPQLTGKRIVIDPGMGGEDKGLAVPTEFGDVYESEILWDLASRLEGRMAATGMETFLSRPWGANPTDAERAETSNTFDADLMISLRCAANLSSSAGGVASFHFGNSHGSVSMIGQVLAGFIQREIVARTSLQDCRTHARTWDLLRLTKMPTVQVDIGYLTNDYDASVLTNPRMRDVIAEAILISVKRLYLLGQDDQPTGTYTFAELLAEELAAADRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCN5</accession>
    <name>A0A231HCN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysulfide reductase chain A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psrA</name>
        <name evidence="6" type="ORF">B7C42_01563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46592">
        <property type="protein sequence ID" value="OXR46592"/>
        <property type="gene ID" value="B7C42_01563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="737" mass="78959" checksum="07D38F990D5A9934" modified="2017-10-25" version="1">MSRVTAEARTTYRTCPLCEAVCGLEITLDAEDRVTRVRGDRDDPFSRGFICPKGASLGALDADPDRLAEPIIRDRATDTWRQATWAEAFDLIAERAPAVLDEYGRQAAALYLGNPNAHTIAGALYVPALIRALSTRNLYSASTADQMPKQVSSGLMFGDPLTVAVPDLDRTDYLLMLGANPLESNGSLCTAPDYPGRLKALRKRGGRLVVVDPRRTRTADLADEHLFIRPGSDAYLLFGIVHTLFAEDLTDIRDEVAGLEQIRSAAIPFTPEAVQARTGIPAETVGRLARELAAAPTAAVYARIGTCTAEFGTLTQWLVDVINVLTGNLDRPGGAMFATAAALGIVRTRPFRLGRWASRVRELPEAMGEFPVATLADEILTPGEGQVRMLVTVAGNPVLSAPAGARLGEALAGLDFMVSVDRYLNETTRHADVILPPPRTLQAPHYDFALLQFAVRNYARYSPPVVALPGDRPSEPEILARLALSLAGQQPEAGTDCVAAVDELIIAGTLHKAGLGARRGELIGANSTEQRIDLMLRLGPYGEWNPDRRSVDIAPEGLNLQVLLDNPHGVDLGALQPRLPGVLRTASRKVELAPQQLLDDTTRLLAEMSAARPDVVLIGRRHLRSNNSWMHNVPALVGGSNTCTLHIHPDDVARLGLGELAAIESASGKLTVPVEPNDRIMPGVVSLPHGWGHAGSTQTAAREHAGVNANALTDDSRIDAVSGNAVFNGVPVTITPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCP7</accession>
    <name>A0A231HCP7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative monoacyl phosphatidylinositol tetramannoside-binding protein LpqW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46556">
        <property type="protein sequence ID" value="OXR46556"/>
        <property type="gene ID" value="B7C42_01527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371122" evidence="1">
        <location>
            <begin position="28"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="115"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="558" mass="61002" checksum="54EF343344B77499" modified="2017-10-25" version="1">MRIRSRALRMTAVVVAAGLAVALAACASVDTTNGPAALGSANDINPQPRDAVREGGNLRLAISGYPANWNTLSIDGNELETGEVVWPLMPRSYLIDATGQLTINKDYFTDIQLTGTDPQQVTYTINPKAVWSDGSPITWEDIASEAHALSSVDKRYLIAINNGFDRVEKVERGVDDRQAVLTFTQHYADWRGQFAGNAMLYPKSVTADPDTFNRALAEGITLTSGPFVIRSTDRTQGRIVLSRNPKWWGDTPKLDTITFSVMDQAAYAAALQNNELDAARLNSIEDLATVRSSAELVVRHAPGNLWRHITFNGAPGSILADPALRVAVSKAVDRQGIANAIENGLVSNPKPLNNHIFVQGQEGYQDNSLPFDPAAAARELDALGWKQQGDVRVKDGRRLEIRDVMYNDPTWVRVAQIVQGDLAKVGVKLIIATRQRQGFFSDAMIPGDFDIAQFQFSGDAFPFGSIPQIYAYHPDDEQSNFGRIGSDELNALIEQTLNELDPKKAIDLANQVDRKVFEEGFSLPLTQDPGNYGVRTTVANYGAPGLASYDYTKIGFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDF0</accession>
    <name>A0A231HDF0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46951">
        <property type="protein sequence ID" value="OXR46951"/>
        <property type="gene ID" value="B7C42_00067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="26370" checksum="9BFC514B80229ACA" modified="2017-10-25" version="1">MDISGKAAIVTGGAGGLGEATVRRLVADGARVVIADLAQEKGEKLAADLGNAATFVRTDVTDDASVAAAIAAAAELGELRVTVNAHGGPVAQQRILSRDGAPMPQELFDRTIAIYLSGTFNVLRQSAAAMAALGPLESGVRGLVVDTASIAAFEGQVGQSDYSAAKGGVVGLGLVAARDLSAVGVRVVTIAPGTFFTPAFQLDEEQAEQTWGRAVPFPKRMGRPGEYADLVSFLIGNDYINGETIRIDGAQRFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDY9</accession>
    <name>A0A231HDY9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777010.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47079">
        <property type="protein sequence ID" value="OXR47079"/>
        <property type="gene ID" value="B7C42_00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="24468" checksum="85C6E081D3B2BCC3" modified="2017-10-25" version="1">MSDQTTTAGSRDRVDFWFDPLCPWCWITSRWILEVEKVRDIDTHFHVMSLAVLNEGRDDLPERYVEMMKSAWGPVRVAIAAAEQHGEKVLSPLYTAMGTRIHNRREEYERENRADSLAAVVADALAEVGLPAELAEAATSTDYDEALRKSHHAGMDKVGPDVGTPTIHINDTAFFGPVLSRIPRGEDAGKVWDGAVALASYPHFFELKRTRTEDPQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE26</accession>
    <name>A0A231HE26_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_1</name>
        <name evidence="9" type="ORF">B7C42_00073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46957">
        <property type="protein sequence ID" value="OXR46957"/>
        <property type="gene ID" value="B7C42_00073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="382" mass="41570" checksum="6936973AFD2A675A" modified="2017-10-25" version="1">MKRTLFDDEHELFRESFRRFLDKEVVPHHLDWERAGIVPRELFTTAGAHGFLGMAVPAAYGGGGVTDFRYNYVIHEEVQAAGVNASGLGLSLHNDTGVQYLLDCGSAEQHQRWLPKAVTGELITAIAMTEPGTGSDLGAVRTTAIRDGDCYIVNGSKTFITNGINADLVIVVAKTDPSKRTSGLSLIVVERSHEGFTRGRRLEKIGMHAQDTAELFFDNVRVPAANLLGEEGAGFGYLTRNLPQERLAIATISVAAARAALATTLEYAKERKAFGASIGSFQNSRFALAEMHSEILIATTFVDQCVLAHNAGELSAEEAAAAKWWCSDLQNRVVDSCLQLHGGYGYMAEYPISRAFVDARVQRIYGGTNEIMKEIIGRSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE64</accession>
    <name>A0A231HE64_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47231">
        <property type="protein sequence ID" value="OXR47231"/>
        <property type="gene ID" value="B7C42_00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="17106" checksum="A3E1244EF7006C23" modified="2017-10-25" version="1">MADIDRVVSAEREIAAPAGHIFELIADPAQQPRWDGNDNLDRAETGQRVRSVGEVFAMTLTNGSVRENHVVEFEEGRRIAWLPAESGQRPPGHLWRWELEPVDESRTLVRHTYDWTRLTDEVRLPRARATTSDKLLGSIDRLAALASAADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEF7</accession>
    <name>A0A231HEF7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47156">
        <property type="protein sequence ID" value="OXR47156"/>
        <property type="gene ID" value="B7C42_00278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="28639" checksum="2FBC619B0A8BC43C" modified="2017-10-25" version="1">MSDERALVIGGGGVAGIAWANGVIAGLADAGIDLTAADLYLGTSAGANVAAQLTSGLTPEELFRRQIDPAVQSAEIVPEGNPLEGVWETINQIITESGGDMAVARRRLGNLALATETVPESDRRAVIESRLPVHEWPGQRLLITAVDAGTGEPRVFDRDSGVALVDAVTASSAVPLVWPPHTVDGVRYTDGGVRTSVNADLAAGFERVLIIAPLPDPALEGEVAGLIEGGARVETIAPDEAAIAAFGANPLDTASRVPSAHAGRVQGKSAAARIAELWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEG9</accession>
    <name>A0A231HEG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">modA</name>
        <name evidence="5" type="ORF">B7C42_00464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780021.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47341">
        <property type="protein sequence ID" value="OXR47341"/>
        <property type="gene ID" value="B7C42_00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011243730" evidence="4">
        <location>
            <begin position="28"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="26536" checksum="A7EED8D63FE6FC32" modified="2017-10-25" version="1">MQIFRIAGAAAAVVAVTAALAGCGSDDATTTSATGELSGTVAVFAAASLTETFTTLGHDFEAAHPGVKVVYSFGGSSALAEQIKQGAPADVFASAAPANMQQVVDAGEVTAKPDTFVSNRLEIAVPKGNPGKITGLADFGRTEPRIALCAVQVPCGAAAEKVFQISGITPQPDTREQDVKAVLTKVTLDEVDAALVYRTDVRAAGDKVQGIDFPESGKAINTYPIAPLAKAPNAAAAAAFVDYIHSDPAKKVFAAAGFDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEL5</accession>
    <name>A0A231HEL5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase 1</fullName>
            <ecNumber evidence="2">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qorA_1</name>
        <name evidence="2" type="ORF">B7C42_00424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777816.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47302">
        <property type="protein sequence ID" value="OXR47302"/>
        <property type="gene ID" value="B7C42_00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="31647" checksum="FDDE518100F29E65" modified="2017-10-25" version="1">MAQAVKFDRYGDIDVLEVREIPDPQPGPGQVAVEVVAAGINPGEAKIRNGSLHERWPATFPEGEGTDFAGRIVALGEGVSGIAVGDEVLGFSDKRSSHATRVVVPAQQVTPKPVGLSWEVAGSLYVAGTTAFAAVRAVSPEAGDTIAVSGAAGGVGSIVVQLLRAREVTVIGIAGPDNQDYLRELGAVAVEYGDGLAERLREAAPGGIDAFIDTHGNGYVELALDLGVKPERIDTIIDFAAVEKYGVKAEGNAAADTIDVLAQLAELAAAGTVRIPIAATYPLGEVRAAFAELERGHTRGKIVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEN4</accession>
    <name>A0A231HEN4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase YwpJ</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ywpJ</name>
        <name evidence="1" type="ORF">B7C42_00390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47268">
        <property type="protein sequence ID" value="OXR47268"/>
        <property type="gene ID" value="B7C42_00390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="27968" checksum="C1380185240E9C8E" modified="2017-10-25" version="1">MNSPRLIALDVDGTILQAGAPMSPRVRAAVRAAVDAGAHVVITTGRTLLATRLVMEELGLEQGQALCSNGAVHVDISNWEPLAVHTFDPEPAVATLRALLPDMVLSVEKVGVGTWATGYYPGSFRLGEFRFVDDAELSLEPTTRLNGWWPGGSLDEMIDAVGELDLPGAGWVHGEDEPWLVASKQGVSKGWALEQLRLALDIPLEQTLAIGDGYNDIEMLTWAGHSVAMGNAVPPVHELADETTADISEDGAALVLERWFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEQ5</accession>
    <name>A0A231HEQ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4,5:9,10-diseco-3-hydroxy-5,9, 17-trioxoandrosta-1(10),2-diene-4-oate hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hsaD_1</name>
        <name evidence="2" type="ORF">B7C42_00337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47215">
        <property type="protein sequence ID" value="OXR47215"/>
        <property type="gene ID" value="B7C42_00337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102296">
        <property type="term" value="F:4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="284" mass="30822" checksum="8B12FC9BB66A4486" modified="2017-10-25" version="1">MGFTAEDTTRWVTVDGVKLRYHEAGSGAPLVLLHGSGAGVSGWANFGANLEALAPHFRCLVLDQPGFGASERPETYDRNYLRIAVDAVLGLLDELGIGSAHLLGNSMGGAVATLLAAEHPDRADRLVLMAPGGVGVNILGPEPSEGIRRLLDFNADPTPERAVDWLKTMVFDQAVLTEELIAARTAAASDPRQTKALADAYATFYNPAFADPVPLWARLRAIQHEVLMLWGRDDRVTPVEGALLPARQLPRADLRIFSRCGHWVQVERKDAFERAVIDFLHNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HES7</accession>
    <name>A0A231HES7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pknH</name>
        <name evidence="9" type="ORF">B7C42_00512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47389">
        <property type="protein sequence ID" value="OXR47389"/>
        <property type="gene ID" value="B7C42_00512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="748"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="868" mass="90426" checksum="46E851FDB56D2863" modified="2017-10-25" version="1">MDVPRSRVGTRFGPYEVRSLLGRGGMGEVYEAFDTGRDRVVALKILPEQLAQDATYQDRFRRESQAAARLAEPHIIPIHDWGETGGSLFLDMRLVRGENLRTLLRRQGKLDADRAVAIVEQVAAALDAAHAAGLVHRDVKPANILVTPADFAYLTDFGIARDEGDNPHTTGSHAAGSYTYMAPERFDSGPVTARADIYSLACVLHECLTGATPFPAESVSVLIRSHLSEPPPRASAARAGVPEAIDDVIARAMAKAPADRYQTAGQFAAAARAALGLGGRMPANSSAAGTPFDSGTPKVFGAELLANTPRGASPSHGPDPVSVAAARDNDYRRTPEPTTFQPFGPDGPTIAANFQPRSSAAAGDSAAGGADASTGTANAATAQSVSAASGAGPVQDGPAGANRPADAPAATSRAYETTGTLRIIPPPNKDERDTSGDLPIIRPADPTLVEPGEFHFTLPTETPAAQSKPATLPSLPMRKPPAAGAAGSTRQTSEPVVPRAAEPARRPAAESSRAYGVIGSEETDDRTEQPVAEQDSIPASDYRTQLLDPAQFSTDPEATARSDADTALGSDADLQPGEKTELIDVSQFRTGGTDHAPGAEENTRFLDVSQFGTVAEGAGDTRFLDVARPGDEDYGDDTRYDDDLRFRDDARYDEDDRYDDARYADARYEDDDRYADDDYDDEFAFAATGSEDTRPAKRSRSVRVPVVLGVLSAVVLAGLGIVGWQVFGSSGSNDHPATAAAPAAPAVTAQQPATSSARSTTAAPTTTGTSATLPVGATPCSQTSTSQGSFGKTATGSEVTSCGFAEAVRKAYAQAAESHGATSAATAEASTSIIAVSPVTGRSYPMTCTSSGKVVTCTGGDNAVVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFJ0</accession>
    <name>A0A231HFJ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubiB_1</name>
        <name evidence="3" type="ORF">B7C42_00866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47741">
        <property type="protein sequence ID" value="OXR47741"/>
        <property type="gene ID" value="B7C42_00866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="106"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="465" mass="50608" checksum="CE6190F3D1414BEC" modified="2017-10-25" version="1">MTAAATETASGPGAGETPPQPVPALEKFGFAEFRRTAAIGTTIGSRVTRRVLRQGLRPAKRRRAMAEGTVDGFEALGPMFVKLGQLIASSPASFPDELADACLRCLDDVPPFPATDARAVIEADLGAPIDRLFREFDDEPLSAASVAQVHACVLADGRPAVLKVQRPDIARRMIVDLRAAYRLAGSLTKRSENARIANAEGVVRDLYDTTVAELDFRNEARNQAQARADLSAFGDNTGVVVPEVYWEYCGPRVLCMERMRGMPLDRFDDIRAAHPDPELLIRRLVKAWVESVVVHGLFHGDVHAGNLWLLDDGRAAMLDFGIVGTMTPQWRAFVRALFHASAIDGDFRPVARALRELDLLDGDDGDDATIGRQLATALAPVLSGKLAQLDMGKVAARLVEFGKRRGASGPQQLLLMGKQLGYFERYAVALAPGWRLGQDLYLFRNIFPEEVTAKVAAEGIELPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFR6</accession>
    <name>A0A231HFR6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779664.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47823">
        <property type="protein sequence ID" value="OXR47823"/>
        <property type="gene ID" value="B7C42_00948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="6903" checksum="BD6670D1DFE4F81A" modified="2017-10-25" version="1">MRVIVDNTKCDGYGTCFDMCPSVFRSDDWGYAAAVGDGSVAESDETLVRRVISLCAEHAIREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFV9</accession>
    <name>A0A231HFV9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc metalloprotease Rip1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">S2P endopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Site-2-type intramembrane protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rip1</name>
        <name evidence="15" type="ORF">B7C42_00712</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779611.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47587">
        <property type="protein sequence ID" value="OXR47587"/>
        <property type="gene ID" value="B7C42_00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="13">
        <location>
            <begin position="10"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ_6" evidence="14">
        <location>
            <begin position="157"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR47587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="44005" checksum="4F0DA7EFFD34E9CF" modified="2017-10-25" version="1">MGFAIGFVLFALGITVSVALHECGHMWAAQATGMQVRRYFVGFGPKVFSFRRGETEYGLKALPLGGFCDIAGMTALDEVPPEDLHRAMYRQATWKRLVVMFGGIAMNFLLGFLLIMLLAVAWGLPRLDSPPATQIYPAGCVPAQNPDGSMQKCTGPGPAERAGLQRGDLVTAIDGKPVKTWDDFRSITEKANGPVVYTVKRDDQTLQIPVTPERVATYPLKSTGSSERVTTPVYVSKVGVAQDFYLPVKHNIVSAVPASVTFTGDMFGRTFASLAQMPSKVVSLWHAVTGGQRDADTPVSVYGASKIGGETAEHGLWGAFVLVLASLNFFLGAFNLLPLLPLDGGHIAVVIFEKLRNMWRNRKGLPNGAPVDYMKLLPATYIVVVIGGAYMILTLVADIVNPIKLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG06</accession>
    <name>A0A231HG06_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase [NADP(+)] GabD</fullName>
            <ecNumber evidence="5">1.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gabD_1</name>
        <name evidence="5" type="ORF">B7C42_00781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.79" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47656">
        <property type="protein sequence ID" value="OXR47656"/>
        <property type="gene ID" value="B7C42_00781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="29"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="491" mass="50997" checksum="75B6A7C2A29C00A4" modified="2017-10-25" version="1">MTHTVTESDEATISAIDSVPTGLFIGGRWRDTAARLPVEDPATGQTLTAVADAAPEDGVAALAAAATAQAGWAEVPARTRSEILMRAHRALLDETERLARIATAEMGKPLAEARGEVAYAAEFFRWFAEEAVRLDGGYMPAPTGGSRFVVARRPVGPSILITPWNFPMAMATRKIGPALAAGCTCVVKPAEQTPLCTLAIGEILSAAGVPDGVVNVVTTSDPAAVTGAMIADPRSRKLSFTGSTAVGKILLEQCAKSVMRTSMELGGNAPLIVFDDADLDTAVDGALAAKMRNIGQACTAANRIYLQRGIAEEFTRRFTERMAALPMGPGADPGVVVGPLIDAAAVAKVSELVADARRRGATVLLGGTAAEGSGYFYPPTVLTGVPDDAAMFGTEIFGPVAGLAVFDTEDEVIERADDTPYGLVAYVFTENLRRGLRVSEALDTGMVGLNQGVVSNPAAPFGGVKESGLGREGGLGGIDEFLETKYIGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSM6</accession>
    <name>A0A231GSM6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000126">
        <property type="protein sequence ID" value="OXR39623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39623">
        <property type="protein sequence ID" value="OXR39623"/>
        <property type="gene ID" value="B7C42_08308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="50"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="26705" checksum="7CD2A2B96BB845AF" modified="2017-10-25" version="1">MNALCDSYGASDEERRICLDLVKEIRASREGKVTASWWRAYADQISTGFNHYLALEDAADRLTIWKTTIVPGLLQTPDYRRALAWAEHPDLPGEQLERRIEWQTHRQERLGDANVRITALLHEAVLADQVGGEAVIREQLKFFVSLSERPNISIRVVPFTASSALGSYVGSFTLLQFPDLISGLAQPPIVYVEGWAGDLYLEREAELQRYLPALREIRRVALTEGDSIALIKERMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GST7</accession>
    <name>A0A231GST7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000085">
        <property type="protein sequence ID" value="OXR39690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39690">
        <property type="protein sequence ID" value="OXR39690"/>
        <property type="gene ID" value="B7C42_08236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="23289" checksum="BECB2CED94FB5281" modified="2017-10-25" version="1">MATTEPPHGIEDLAGQVNDINVEEERAQIAAERAKVAAERAALEHEQALVRQRRVREDQQQPTVLEPSGEPVAQEPAPRSYTPAVVDSDGGEFEVDVETGEVIRDSFGQPIPKWKHQTVELDGEIIQVRKPAPQALQAFSMAISKYAPPQIQMDMANLFVKNHISPLSYGRLLARMMDPEESFTMEDFGRLIEKIATLDTARPIEPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTJ4</accession>
    <name>A0A231GTJ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39898">
        <property type="protein sequence ID" value="OXR39898"/>
        <property type="gene ID" value="B7C42_08044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="570" mass="60922" checksum="BF3D7A735858FC85" modified="2017-10-25" version="1">MVAEAETITAEAADQGAAVTASTRPVSFRGLGARSGRTPGRVAAPNASEQTGFRMRDQVPNFTPGVVGFQELAASLNAMATNARVHPNRAPHRDRANLVPLSLATLDRGFTDEYQIRAANSEELKAAQDQLVAKTKWRPAQFKDDGALVASGGHCAVPETIYTFCDVTPASGLLTLPAANFGPRGGQRRPLDPDFTELYNTLPFRFTEEELIATNPDGTPVVTKPCIEIPCTEWEEILVEAIGLCVTAGILQKRGFPEEIERFLAEVTKAHLIKVSLWSILDMVAVSNSYTIPGAGNIGAAGALLNSLALRATMIRQQERLPHDAIIEGVIPAYALEVVKADMTFQQGLDVKAVTDQQIDAWLASKNIRMQWVQHWQPLPTASVRWPNKVQALLYPAGAFVQHLENVIEVGALFDKAQLQKNRYTELFTEDEYAVDKRCRVSEIVEVPLCVNGSVAAREQITCSAPANEVQAITITGSPTGGTWTATFKGDTTKPIAYNATAAQVATELSLLKTIGAGNVAVSGSAGAWSVTFQGLLGNTNVNQLTVTGSFTGGTTPAIAVSTTTAGAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTJ6</accession>
    <name>A0A231GTJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782414.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39939">
        <property type="protein sequence ID" value="OXR39939"/>
        <property type="gene ID" value="B7C42_08002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="40301" checksum="F470709825F41CE8" modified="2017-10-25" version="1">MNHNTKTDAADFVALERRYRPQIVAGLRAAGLSYGEIRRTLGIPLRQVEKQLGEAAALRAQGYSVAEVAAELGVPAGSMGRILPGPRQDTATERQAEVLSATSHMHGLQIDVLAEFLSVHESSAYAIARVLVDNGWASLAKVQRGRAWLYPKRDVAARYLGWRPSEWEPPLMFAHHYRAVAQARIMLVGSDPQAWVSERVLRHEAGKRLRAEAEARNRKPVLEFSTGREPMPNRPHVHDGWFCGVIDGTYGWWALEVELTEKDPNHLDSALAGAFRSARDAQPHRLVGVLYLCRTERVIAAVTAAKKRLPRELADLPLLFAVGDFDEQWQQHTDKRRAMRAAKSANRHRDNLIRLSKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTV3</accession>
    <name>A0A231GTV3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043595.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40022">
        <property type="protein sequence ID" value="OXR40022"/>
        <property type="gene ID" value="B7C42_07906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17791" checksum="EF054C7A2B6A5DD5" modified="2017-10-25" version="1">MSWQRGWGGAALPVSGSDGPAVIDHGIASGFADTPQGAALAACDALARTLAAPENLWQKVVRARFVGDADAFIARVTRSRTRTPDAARYVTVPDGIRIRTGYRPDFAVVDIATRTRDGYTAVSWPMAYDNDWRVRLPDDIETLWQPGDPIETLVGFGQWRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU14</accession>
    <name>A0A231GU14_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40096">
        <property type="protein sequence ID" value="OXR40096"/>
        <property type="gene ID" value="B7C42_07851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="27184" checksum="2B9800239869357D" modified="2017-10-25" version="1">MLRAQLDSAALAAAVRVDTKTVNRWLAGRVPHRRTRAEVARILHEPEDALWPQTRPDQSAGAPATAEVVGAYAHRADIPTDLWVQLLHKATKQIDIIGYAYPFVFELLPNASDLVVEKCRAGARVRLAFADPECDHVLERDSLEQMGGTLPGRIRNALSMLGTLTDAPGCAVGLHTTHLYNSVFRFDDEMIVTPYLFRARGYQHTALHLRKLSSHGIFESFADQVEQIWETTTGYSQGVRDGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUD1</accession>
    <name>A0A231GUD1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposon gamma-delta resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tnpR</name>
        <name evidence="8" type="ORF">B7C42_07654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40229">
        <property type="protein sequence ID" value="OXR40229"/>
        <property type="gene ID" value="B7C42_07654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5 6">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="21431" checksum="4AEE626E7DAF24C7" modified="2017-10-25" version="1">MEFGYARVSTTHQDLERQLVALREYGIPEDRIYTDRKTGATMDRPGWGKLQKMLREGDRIVATNLDRYGRNLRECLNIVHDLREQGVGIKTLKDPIPIDTGDASPMAEIAVALLALFAHMERVFMHERAAHAREVAAARGVRAGRPRKLTTDQLAAAQAALGAGQKPESVAAAFGVSRATLYRYLAEEKTEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUD6</accession>
    <name>A0A231GUD6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40240">
        <property type="protein sequence ID" value="OXR40240"/>
        <property type="gene ID" value="B7C42_07665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="9231" checksum="56C0E1017A627E6F" modified="2017-10-25" version="1">MAKADPKVAALNASIEARLSRYVSDRRHIAAASAHDRVQRKLMQEHQPESGQWGAPCLGDHAEPTPWPCDSMKSFDNPLAYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUK4</accession>
    <name>A0A231GUK4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782467.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40309">
        <property type="protein sequence ID" value="OXR40309"/>
        <property type="gene ID" value="B7C42_07647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="23059" checksum="E8981D04F548BA68" modified="2017-10-25" version="1">MARRNSNVLSGDVEEARGQILEAAQSTFLHFGVAKTTMDDIAKAAGVSRPTIYRYFRDRDTLIAELIRLRSRKLFVKGTKYVLEREHFRDQIVDGLIFLVDRGRKDPLIRLIVSPEHMDLAAAVVGTSRLASDLTLEMWGPILDRARETGELRQDITNEEACEWLALVQLILVGRLDFEDPDDPAHRRLLETFMLPAFLAPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV90</accession>
    <name>A0A231GV90_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780066.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40492">
        <property type="protein sequence ID" value="OXR40492"/>
        <property type="gene ID" value="B7C42_07430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21540" checksum="DD601FD66F876C0C" modified="2017-10-25" version="1">MNARHRLGPHRDPEVDRAILEAARELLVERGYAAVSIDAIATRAGVSRPAIYRRWPSKAHLIARAVFPDVGGEEVASDLVEEIRTVIRGTIQLFGARPAREAMPGLMTEMRADSGLYQKLSARLDTPTRRELARYLDSGAVRGGVDSDTVLDMIAGAALFAMCIRDIDDTEGFARSLEELVLYGLVGVPASEAEEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVE9</accession>
    <name>A0A231GVE9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40525">
        <property type="protein sequence ID" value="OXR40525"/>
        <property type="gene ID" value="B7C42_07464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012466493" evidence="3">
        <location>
            <begin position="39"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="41649" checksum="ED2CFA19561596BA" modified="2017-10-25" version="1">MKEGTAISASGVRPRKVATALLVLFVATILAEPEPARAAPDSGCPVLWVLGVQGTGQSSPTASRTDDTGVLGALLGPVGAAVPDLVQHTYIPYPAGFGGAPGVGGGAESYTASVTEAVADLATTAEQIAASCPATRLAMVGYSQGAQAVSQLARAIGAGNGPVPAETVAAVALYADPERRAGSPVFPGRPGQLTPDPAPGTSGTAVASVQITAPAASGGGIADDDADYGTLTGRVLDICVDGDLACSTPEHAALLRTGALLAAQADLSNPVAAIAGMHHVLTQALGSAWATVVLDDILISPATVDYSPRKPLSQRIIDASDPRVAAPPPERVAAASERWNQVTATVAAHPVEAAKLAGQLAGAWGQLVADNADLANPAVWARLAATVPLHDGYPNGQLATGIAWLMAVAHDLSQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVK3</accession>
    <name>A0A231GVK3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780518.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40585">
        <property type="protein sequence ID" value="OXR40585"/>
        <property type="gene ID" value="B7C42_07394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="33462" checksum="883D0E31F6D7D38E" modified="2017-10-25" version="1">MTAPLRATDHEPEIPGDELTPETVREHIDGVAAFLGGAANVIMQLSHPPVGYGVLESTVDSGKVTLHPIKRLRTTLTYLAVAWLGNDEDVRSYREAVNASHRPVHSGPNSPVKYNAFDPKLQLWVAACLYWGVDDLYQRMRGPMDPELAERFYRYSVRLGTGLQMRPEMWPADRDAFYAFWEENLATKTIDEPVRRYFNDLIDLKMQPRLIQLLAGRFHRFTVTALLPQHLRDEMGMRWTARDERRFRFVLRSISAVWTRMPTVIRVFPFNFYLADMRLRRRFGRPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVR6</accession>
    <name>A0A231GVR6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_07236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40678">
        <property type="protein sequence ID" value="OXR40678"/>
        <property type="gene ID" value="B7C42_07236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="399" mass="43889" checksum="9E558B22587B8231" modified="2017-10-25" version="1">MTPEQIAVVFRAEYGRSVAVLIRMLADIDLAEDAVADAFAIALHRWPQEGPPPSPAGWIITTARRRAIDQLRRESARAGKYAEAAILHAPPDDIEESAVPDERLRLIFTCCHPALNRPAQVALTLRLLGGLTTPEIARAFLVRETTMAQRLTRAKAKIRDARIPYRVPGEADLPERLDSVLATLFLIFNEGYVASSGPELLRADLCEEAIRLTRALVASMPDEPEAAGLLALMLLTHARRDARTDASGAFVRLGDQDRGRWDTALVAEGRAIVRACLRRNRPGRYQLLAAINAAHTDAVTDWTQILALYDRLARLDPNPVVALHRAVAVAEVDGPAAALTLVDAVPLSEHYLFHAVRADLLARLGRADEARRGFETAARLTDNQRERDYLATRSAALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVW8</accession>
    <name>A0A231GVW8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40715">
        <property type="protein sequence ID" value="OXR40715"/>
        <property type="gene ID" value="B7C42_07139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="105" mass="11611" checksum="42B0C560B08628E1" modified="2017-10-25" version="1">MTDFQVVPDDVDKFSGALRDLAGQAGAAGTHVTKWFNLSDAHTGIFVEVRGIVEHIRQNLEDNYKHLQTLADGSATELAKAAQLYRTTDSEHARQLDETYPGNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVY2</accession>
    <name>A0A231GVY2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40756">
        <property type="protein sequence ID" value="OXR40756"/>
        <property type="gene ID" value="B7C42_07180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189493" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="7703" checksum="E52636AB662B3A85" modified="2017-10-25" version="1">MKRLAVLVVAVAAFGIAPAGIAGAETGIPLEYNNTEEITANRPVVLQTGSTVIDLLAYIGAGCIGSWSPAPPAHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWE6</accession>
    <name>A0A231GWE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid-associated protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybaB_4</name>
        <name evidence="3" type="ORF">B7C42_07095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40811">
        <property type="protein sequence ID" value="OXR40811"/>
        <property type="gene ID" value="B7C42_07095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15692" checksum="E7E30C44AC85E24D" modified="2017-10-25" version="1">MDPLSAGDDFRYLARTEVNQLLDNYEEQMASLAEIRRRLDSLRIQARSTDGTIEVSVDSAGVVTEIKLEPAAMRNKPEDLARKLTEVIREAAMHAEKHTAEAVAPVSDIVDPLPDLPDLLPGAPSLRNPVPPEDDPEDAAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWH2</accession>
    <name>A0A231GWH2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione transport system permease protein GsiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiC_5</name>
        <name evidence="6" type="ORF">B7C42_07050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783792.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40915">
        <property type="protein sequence ID" value="OXR40915"/>
        <property type="gene ID" value="B7C42_07050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="99"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="317" mass="33815" checksum="901E647046C46264" modified="2017-10-25" version="1">MLRYVAAKLAQAVFVVWGAYTVTFALLYVLPYDAVDVLFDPAQGDLITAGDKQKARVYYGLDHSLFGQYLHRLGQAVHGDFGRSTRTGLDAWAMISSVLPQTAVLAVTALVLAVALATVVAIVAAYTRWRWLAELFATLPAAGVSIPVFLLGLAALQVFSFRLGWFPPIGNDGVASLVLPAVTLAIPVSAPIARLLLENLDSGMRAGYVTVSLAKGATRLWVVVREVLRNAALPALTIAGVTFGNLLAGAVIVETVFSRSGLGRLTETAVRTQDVAVVQAVVVLAAVIFVVVNLMVDLVYPVLDPRLRARLYARSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWS8</accession>
    <name>A0A231GWS8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40961">
        <property type="protein sequence ID" value="OXR40961"/>
        <property type="gene ID" value="B7C42_06927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016499">
        <property type="entry name" value="NucleicA-bd_Rv2694c_prd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006910">
        <property type="entry name" value="NA_bind_Rv2694c_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="15175" checksum="E907D819ED8DC906" modified="2017-10-25" version="1">MPFTGGNKAGSGAAGKVGPDSGYFRRLGRRLTADLDVLDAEELAETSEASGACRAAECRRGEEVTMLGRLRSVEACPKSASASVEAEFFDGTDAVTLVWIGRRRIPGVESGRRILVRGRIGERDGDKVMYNPYYELRENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWT7</accession>
    <name>A0A231GWT7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">secA</name>
        <name evidence="17" type="ORF">B7C42_06818</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41048">
        <property type="protein sequence ID" value="OXR41048"/>
        <property type="gene ID" value="B7C42_06818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="3"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="89"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="404"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="842"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="918"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR41048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="945" mass="105335" checksum="6898EE51B77BCC61" modified="2017-10-25" version="1">MPALTLTRLLRFGEGRTVKRLAHLADEVLSLDDEYADLTDAELRAKTDEFKQRYADGETLDALLLEAFAAAREASWRVLNQKHYKVQVMGGAALHIGNVAEMKTGEGKTLTSVLPAYLNAISGDGVHIVTTNDYLARRDSEWMGRVHRFLGLQVGAILSGMSPAERRAAYSADITYGTNNEFGFDYLRDNMTHSLDDLVQRGHNFAVVDEVDSILIDEARTPLIISGPADASSKWYAEFARIAPLLKKDVHYEVDIKKRTIGVHEAGVEFVEDQLGIDNLYEAANSPLVSYLNNAIKAKELYVRDKDYIVRNGEVIIVDEFTGRILVGRRYNEGMHQAIEAKEGVEIQPENQTLATITLQNYFRLYDKLSGMTGTAETEAAELHQTYGLGVVPIPTNKPMIRMDQADLIYKTEESKFAAVADDIAERHEKNQPVLIGTTSVERSEYLSKLLTKRGIPHNVLNAKFHEQEAQIIAEAGRPGAVTVATNMAGRGTDIVLGGNPDIITDTLLRRQGLDPVETPDDYEANWLPALEQVKRQVEDDADLVRDAGGLYVLGTERHESRRIDNQLRGRAGRQGDPGESRFYLSLGDELMRRFNGAALESIMTRLNLPDDVPIEAKMVSRAIKSAQTQVEQQNFEIRKNVLKYDEVMNQQRTVIYAERQRILAGEDMEGQVQSMITDVITAYVDGATSEGYVEDWDLAKLWTALKTLYSVGIEYQDLTGETEDGEIGELSREELLEAILEDAHDAYARREKEIDDLAGPGSMRNLERQVLLSVLDRKWREHLYEMDYLKEGIGLRAMAQRDPLVEYQREGFDMFAAMLEGLKEESVGFLFNLQVEVQQAPEQQPAVDPGLRSPVGAMHPAPAVPQGNGAAENAPAALRAKGIDESGPRGLSFSGPDEGGHAEVRSAAQEYGDTPATGMTRRERREAERDRAKQGKPAKTKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWZ3</accession>
    <name>A0A231GWZ3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dcuR</name>
        <name evidence="5" type="ORF">B7C42_06801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41031">
        <property type="protein sequence ID" value="OXR41031"/>
        <property type="gene ID" value="B7C42_06801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="25407" checksum="42173082970AC325" modified="2017-10-25" version="1">MTRPPIRVLIVEDEPRIAEAHHSYVARVTGFEPVGVAATGRDAIRTATQAAAAGTPIDLVLMDLGLPDIGGLEVTAALARLRPRPDVIAITSARDLEMVRAAVAHGIALYLLKPFTFAAFRDKLERYLEFRAALPAGDATLTQHDIDRALSALRTADPRAAAPKGIAPQTLQEISRAVREAPDGLSATETGRAVGVSRVTAWRYLEQLATDGVVERRSDYGRAGRPQVRYVWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX01</accession>
    <name>A0A231GX01_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,6-dimethylbenzimidazole synthase</fullName>
            <ecNumber evidence="2">1.13.11.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bluB_2</name>
        <name evidence="2" type="ORF">B7C42_06811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.79" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41041">
        <property type="protein sequence ID" value="OXR41041"/>
        <property type="gene ID" value="B7C42_06811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102919">
        <property type="term" value="F:5,6-dimethylbenzimidazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="21305" checksum="644B855E161BE210" modified="2017-10-25" version="1">MRAEFTGDLVDDATLLRILDAAHRAPSVGNSQPWDFVVVRDPATLTRFAAHVAGKRIEFRDSLPPERARTFEPIKIEGITESGTGIVVTHDDSRGGPQILGRATVPETGLYSTVLAIQNLWLAATSEGVGVGWVSFYDAPFLTDLIELPAGIRPVAWLCVGPVREFQQTPDLERFGWRDRRPLGDAIHWERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXC5</accession>
    <name>A0A231GXC5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41256">
        <property type="protein sequence ID" value="OXR41256"/>
        <property type="gene ID" value="B7C42_06654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="81"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="25467" checksum="0776E5A36B2D1B5F" modified="2017-10-25" version="1">MDEPVLIQPTASILSGSTKPVPALDISLGGTPRGLVVLICERGALNREGPGLMNRLAEHGYESLAVEAGSVDASDLDVLMARADDRNWIDEQIGLVGVGHGGSAVFEAAAQRELAAAVSISPAADGPGLLDFDDVVRTPWLGLFGDADPSVSADDRRALASRLAARSQIYTEVVSYPGVGRDFYRYGDDGPGYAAYYDSWQRTVEWLDARVAPRPTARARRWRRCRLETGIEQDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXJ0</accession>
    <name>A0A231GXJ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcC_3</name>
        <name evidence="3" type="ORF">B7C42_06690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063001613.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41292">
        <property type="protein sequence ID" value="OXR41292"/>
        <property type="gene ID" value="B7C42_06690"/>
    </dbReference>
    <dbReference type="GeneID" id="66723611"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="11179" checksum="BF2CACBDB3CDF764" modified="2017-10-25" version="1">MPTVVYRLPDGTAHSVDVPAGQTVMDGSVRNNLPGIVAECGGSCSCATCHVYVEDESAAAFGEPSMEEQDLLEFLDGARSCSRLACQLVLNAEMEPITVTVAQSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYC2</accession>
    <name>A0A231GYC2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41596">
        <property type="protein sequence ID" value="OXR41596"/>
        <property type="gene ID" value="B7C42_06237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7607" checksum="D4953052B8210418" modified="2017-10-25" version="1">MLYFNGGLDEYGIDESTRRGIERSDALALFPRFGSTPAKPAAPLRDRVRRDVRRRIFRMAARAAGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYD1</accession>
    <name>A0A231GYD1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NIR_SIR_ferr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41624">
        <property type="protein sequence ID" value="OXR41624"/>
        <property type="gene ID" value="B7C42_06265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012798">
        <property type="entry name" value="Cbl_synth_CobG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02435">
        <property type="entry name" value="CobG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="1">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="41326" checksum="7F1D6E3DE2156F16" modified="2017-10-25" version="1">MTRSAPDSCPGVLRLHQAADGPLARIRLPGGAITPDQLRVLAAAADELGNGSIELTSRGNVQLRQMHDAAALAERLEHADLLPAPTHERVRNIVASPLSGRSGGWSDVHPLAAQLDAGLQAAPDLAALPGRVLFTLDDGRGDISGLGGDIGIHATDEAEFALVLAGRDSGARIGADRAVDTMLAAAHSFQRARGEQWRLREVPDGPARILAELALEPTAAPVDFVARHDIPIGWLPQADDRVALGAAVPLGALPARTAEFVAAVEHPILVTPWRSLVVADMDEWTAEQVVRVLAPMGLIFDANSPWLAVTACAGRPGCAKSLTDVRADAADAVASGRVLPVGAPTPELSGVAADQVVVAGRQHWSGCDRQCGRPAGPVTEVVAEAGGYRITGPRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYF0</accession>
    <name>A0A231GYF0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41605">
        <property type="protein sequence ID" value="OXR41605"/>
        <property type="gene ID" value="B7C42_06246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="28382" checksum="B1AE6C122C27A579" modified="2017-10-25" version="1">MLAVRDIGAGTEAAARIADSRLGATVSVQQLDLASMRSIRSAAADLRASYPRIDLLINNAGLVAFTKGSTEEGFELHFGVCHLGHFALTGLLLDTLMNTPGARIVTVSSFGHRMAGDGIDFADPHWQRRPYKWVQAYGQAKLANLLFTYELQRRLAAASGTNAIAVAAHPGTTKTQLVRDAPISIRLQNRLLGGLRQGAAMGALPILRAATDPTVVGGQYFGPGGLGELRGYPRIVSSSATSRNAPLQRRLWEMSEDLTGVRYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYL5</accession>
    <name>A0A231GYL5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor SdpR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdpR_4</name>
        <name evidence="2" type="ORF">B7C42_06337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41696">
        <property type="protein sequence ID" value="OXR41696"/>
        <property type="gene ID" value="B7C42_06337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="15827" checksum="A8B58E8F3B86D50A" modified="2017-10-25" version="1">MNALPLIFRFGYIADMASTFEALAEPRRREILDLLRRREYLVGELVTELRLAQPTVSKHLKILRGAGLVEVRHDAQRRWYRLRPQPLTELDRWLAPYRQLWDTSLDALARHLDVMAAAEENTTPTDAETARSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYU4</accession>
    <name>A0A231GYU4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acpP_2</name>
        <name evidence="3" type="ORF">B7C42_06118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515113.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41776">
        <property type="protein sequence ID" value="OXR41776"/>
        <property type="gene ID" value="B7C42_06118"/>
    </dbReference>
    <dbReference type="GeneID" id="66723177"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="85" mass="9148" checksum="C2A512F8FEA85C4E" modified="2017-10-25" version="1">MDENEVRDQVRELVRRHAPQPSAELASDDVLAEQLGYDSLALIELALGLQVRFGIDAGGDSGATNVVTVGDIEQMVCDALRAKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYW9</accession>
    <name>A0A231GYW9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41721">
        <property type="protein sequence ID" value="OXR41721"/>
        <property type="gene ID" value="B7C42_06063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="430" mass="46507" checksum="E6EA9FA54895D93E" modified="2017-10-25" version="1">MVQRLFVGEQGALQDRRGRGRIDVLTEGLHRRRRNSVLLQQLSQRIDGTVAFENGQMIGDDRRGYAQQPGQAGRPVHRPVRAAEVGVVAVVPGLGLGDGEGGKVCGARVMADELRGGVPQRTLLQFRCHLTDGMARRDDRVVGPGRRIGPVGGHGLFVDDDRLTDPAQVHGIADQGVLRRHHHLRATAVAVARGAILGLFVDVGLLGGLGHPDVHAALGLHRLRHRDVDTALALPVDHQDLALLTSFVENLLQLGFPVRTPADDPLGIDRFDRLSGHSCAHQCLDLPGDQIVAVTQDLLEPALASGPHLVRVFGDRAQFGMGALDHIMLSLHQPMCLRPCDLVGLLQTVDLLQYRVQVGEGAGCTGHFIEEGFGSDAVDFDRIDAFGGLRVRAHHDPMRLGLLSSGLGRPELLGFDRLGETRLARFRAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYY1</accession>
    <name>A0A231GYY1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[Acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fabD_2</name>
        <name evidence="5" type="ORF">B7C42_06127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41785">
        <property type="protein sequence ID" value="OXR41785"/>
        <property type="gene ID" value="B7C42_06127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="4">
        <location>
            <begin position="5"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="443" mass="47135" checksum="6796E4DF1CDB2CA0" modified="2017-10-25" version="1">MLAFVFPGQGAQFPGMGKALADTYPVAREIFDRADAAIDFGLSELCFAGDPAELARTEHAQPAILATSVAAYRVLVSETGIHPMVVAGHSLGEITAHVCAGALDIETAVRLVRRRGALMQEAVPPGAGAMVAVMGLAADEVDRICTAAAQSEVVAVANYNGASQVVISGHTGAVGRARHLAEEHGAITRALDVSAPFHCALMAPAAAAFRSELARAEFTSPRIPVVEGTSGRWRTDADPVDSLSAQICAPVRWDVVMAGLAARGVRYVIEAGPGARLTSMLRRSEKGIGTAHFGEPQDLDAVVALLGDRPWLRHEPGYWQHGDRGDLYAPGTSEIVWAGTDDAEPMTDAAWTTRSDGSRQRRYGPMAVITADNALRTYDPAVWTPREDGAYVRRDHTAVEHPATGGDGFDPAEWIVDPSGTMRRRDGSRVIWPDGDEWSFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ16</accession>
    <name>A0A231GZ16_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-keto-5-aminohexanoate cleavage enzyme</fullName>
            <ecNumber evidence="1">2.3.1.247</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kce</name>
        <name evidence="1" type="ORF">B7C42_06154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.247" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41812">
        <property type="protein sequence ID" value="OXR41812"/>
        <property type="gene ID" value="B7C42_06154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="350" mass="38479" checksum="C9223554D90BC5E5" modified="2017-10-25" version="1">MFFHDDALFPENQDKLVITCAPYGPEWEPDDFREDLPLTMEEHIQQAVDCYEAGATVLHIHVRELDGKGSKRLSKFNELLAGLRDAVPEMILQVGGSISFAPEGEGAEAKWLSDDTRHMLAELDPAPDQVTIAINTSQMNIMELMTADDIAGTSMERPELAEAYREMTVPAGPAWVAEHLRRLQAAGIQPHFQLSSIPQLETVERLIRRGVYTGPLNLTWVGIGGGFDGPNPYNIMNFIQRVPDGACLTLETLMRSVLPVNAMAIALGLHTRCGNEDTIWGRKGHKATSVEQIGQLVRIAGELGREVATGKEARDIYKIGTTYADADETLAKIGFAPNRKPGQVGFTHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ97</accession>
    <name>A0A231GZ97_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiB_4</name>
        <name evidence="2" type="ORF">B7C42_05923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41939">
        <property type="protein sequence ID" value="OXR41939"/>
        <property type="gene ID" value="B7C42_05923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="97"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="459" mass="51123" checksum="C6B4F2D6F1E796D7" modified="2017-10-25" version="1">MSNRVPHGRISRGSKMGRLAAGQALRGVGTRLSMVGRTEEARRRLSERSAMQAAQQLVTVLGGMKGAAMKLGQMLSVLDLDLLPEEQREMFRTKLAQLRDQAPAFPFSAMRTVIENDLGTMARTFADFDETPIAAASIGQVYRARLRDGRAVAVKVKYPGVDRAVEADMRNLMLISRLWKAILPSAADEEVLAEIARNIGTELDYPREARTQHHVATRYRGHPYISVPDSIESCCGPNVLVTELVEGEPFGHMRTLPDADRTRLGELIYRFYITSLFTDHEFCGDPHPGNIMLASDGRLAFVDFGLYTAMSPADVELERDIICAAGEYRAEDIYHAWVAQGIVDPDAGVTPDECLGYIWAATGWHLIDEDITVTPELATSAVVLAVDPRAAEFSGMRHQRLPPEHVFSRRADLFTYAVLGQLHTTNNWHRLAREWLYHEPPATEIGAEIARWRLTARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZF0</accession>
    <name>A0A231GZF0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779013.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41942">
        <property type="protein sequence ID" value="OXR41942"/>
        <property type="gene ID" value="B7C42_05926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="16289" checksum="BF715EC0530EC534" modified="2017-10-25" version="1">MRARDVEIGHTYVVLVPHRLPVARYPDRERLGTSMWVASLLMGARFRLTASNVDYDTDPVTVEGLRLIERSHTDVMLTDDQATALGLAPKQGYRVVGSLVDRTGRVACLPSIEPIRVPVRWLRPADDPRLARCSHRDADLWPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZP7</accession>
    <name>A0A231GZP7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42075">
        <property type="protein sequence ID" value="OXR42075"/>
        <property type="gene ID" value="B7C42_05674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013121992" evidence="1">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="12871" checksum="14F925F97FE05216" modified="2017-10-25" version="1">MRDARYARPLVPTTFLAAAATVTVWAPTASAEPLGPLPVYTCDIAEQGLGATELDGTRAIKGQNCEAGEGTPTSGKIEEATLIQPRDNDLAYICNGTVFIHQKIINGQLDVTTDRCRIPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZQ9</accession>
    <name>A0A231GZQ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hca operon transcriptional activator HcaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hcaR_5</name>
        <name evidence="3" type="ORF">B7C42_05687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043609.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42088">
        <property type="protein sequence ID" value="OXR42088"/>
        <property type="gene ID" value="B7C42_05687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="309" mass="33210" checksum="13131B5E0D2290E5" modified="2017-10-25" version="1">MDVRHLRYFVAVAEEQHFGRAAQRLHMAQPPLSQQIRQLEANLGVSLFERTTRKVELTAAGAAYLARARQILASLDDAAREAQLVAAGSVGHLTIGCVGSATASLLPTLSRHLATELPGVEFAFRGEMLVPDQIEALRTGAVDIALLRPPVTDRSLAVEPLRDDELVLATPSDHPLAALAHVDPRELAETDLIVHSADRASVMYSVVMRLLRDAGIQPRIRYQVGETSTLVTLVAGGLGAAIVPAPVSALTLDGVTYRPLRPTTTIGLALAYRAGRTEPHLTRSLDIIKTLTATKDAPPQHLSPQEPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZW6</accession>
    <name>A0A231GZW6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42158">
        <property type="protein sequence ID" value="OXR42158"/>
        <property type="gene ID" value="B7C42_05757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="17793" checksum="5865E3533E8DCA8C" modified="2017-10-25" version="1">MSTLNGLPAHILLVHFVVVLVPLTAVLTIVCALWPAARRRFVWLNLALAVVVVVLTPITTEAGEWLERRVGANPDLRTHTHLGDTFLYFAVASVVAAGLIAVVHVRESRERGLSRLLVGAVAVVAIAASAAATVQIYRIGESGAGSAWHGAATRPVHARAATQGATSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H044</accession>
    <name>A0A231H044_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42237">
        <property type="protein sequence ID" value="OXR42237"/>
        <property type="gene ID" value="B7C42_05836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="25010" checksum="EAE6A313A642C7DF" modified="2017-10-25" version="1">MKAERLVEESFELVARARRARVFHPRGLWFSGHLRPDPAFERYFGDGERDVEVRLSKALGMPGRVPDAVGIGLRVRTPGGRWDLALASTPTGTLTRFFAIPVPSWRHATYGTLMAYRFDGGDPQWIFARPNADQPADASLATLREYATTHGLGFTLTAARLNGPEEPFADLRLTAETVAPPPEDAVDPTLHHPPGVALAPQFITRLRRSAYRGSREGRGAEPSSGPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H086</accession>
    <name>A0A231H086_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_22</name>
        <name evidence="5" type="ORF">B7C42_05760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42161">
        <property type="protein sequence ID" value="OXR42161"/>
        <property type="gene ID" value="B7C42_05760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23278" checksum="C60D4FAD0B540D6D" modified="2017-10-25" version="1">MIAKSLWHAGAMAVQSGVYRGATAAERATERRSRLLDAGLTVWADAGTRTTMTAVCAEAGLSERYFYESFTGLDALLEAVLNRIAVEIEDNSRSAAEAAGDDPEARMRASIGAFVRLLVEDPRKGRVAIVESVAFPHLRRRRTELLRHLAHESALEVRTWLGDSGRSRAADETSGLLFIGGMAELVTAWLDGAIEVSAEEMVEAACRALRGLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0J1</accession>
    <name>A0A231H0J1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42347">
        <property type="protein sequence ID" value="OXR42347"/>
        <property type="gene ID" value="B7C42_05546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046151">
        <property type="entry name" value="DUF6153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19650">
        <property type="entry name" value="DUF6153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="20349" checksum="0853609DFE9531E7" modified="2017-10-25" version="1">MLAVGHLRRAPGFVRALGVLTLLIGIAVMHAVVFSTGHVMGAVAEPAVSSPAAAAPVMAGRSVSPSNDGDRAPIALAAQGMSKIGHGDHAVPATAPGEATAPTVPNEQSPVADRESAAPMRTTLAVADGSDCDGCTTHAGMHACVFVLVTLALALGLAVIAWLGADRTPSAGRLARAGLRRRTRPPPWTVLSLAELAILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0S7</accession>
    <name>A0A231H0S7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42381">
        <property type="protein sequence ID" value="OXR42381"/>
        <property type="gene ID" value="B7C42_05581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="20925" checksum="32C0703EDB51B6E3" modified="2017-10-25" version="1">MTDPATPEPSSGEAGDEQGAPAEADLEIVARQLGREPRGVLAIAYRTPDGQPAVVKTAPRLPDGTPFPTLYYLTDPRLTAEASRQEAAGLMRGMTERLAADPELAAAYRVAHESYLSERDEIESLGTDFSGGGMPERVKCLHVLIAHSLAKGPGLNPLGDEAVALAADTGLRGTAIPQDWPKYEQYQPNTDAGDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1S7</accession>
    <name>A0A231H1S7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Assimilatory nitrate reductase catalytic subunit</fullName>
            <ecNumber evidence="6">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nasC</name>
        <name evidence="6" type="ORF">B7C42_05143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42805">
        <property type="protein sequence ID" value="OXR42805"/>
        <property type="gene ID" value="B7C42_05143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="717" mass="77885" checksum="3A3F581492771086" modified="2017-10-25" version="1">MDTRIVSRQCTLCEAHCGIRVTVEGDRVVRIEGNPDDVLSEGYICPKATAMGALHHDPDRLRTPVRRVGDRFEPIGWDEAFREIGQRLRRIRAEHGPSAIGMYLGNPAAHSSSVLYGVLLRVALATRNFFSASSIDQFPQEFAAWRMFGSNVLMPVADIDRTDRLVILGANPAVSNGSVTTMPNAKQRIKRVRERGGTVVVIDPRRTETARLADQHIAVVPGGDVYLLLAVLNVLIDEKLCDERAVGARCSGWDELRETVAQCTPEVAAPHAGVDAETIRGFARDHAAARSAVLYARIGVCQQVTGTLTHWLVNTINAVTGNLDRAGGQMFATAPVDAARYGKYLPMGHGAWTDRSGRYKSFRSELPVAALADEILTEGRGQIRAMVTYAGNPVLSTPQRGRLDAALESLDFFVAVDMYVTETTRHADIILPPVSQLEREDVNLLFPVFSVRNNLRYDARVFEPPADGLEDWEIMARLVTEVVPLPARRLTGRMLNAMFERLSPVRLAALGIAAGPYGVLRRGRTGLTITKLRASAGGIDLGPLRPRLRTLIGTRDRKVRLAPQDFRAEVAKLLADLPATPPAGADGFDLRLIGRRHLRSNNSWLHNVPAMVKGRDRCTVLMHPADAGARGLADGEPVTVTSSSGSIVVTLEVGDDIRPGTVAIPHGWGHREPGVGWRVAASLPGANVNLLHDPALVDPLSGTAAVNNTWVKVSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2B8</accession>
    <name>A0A231H2B8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42986">
        <property type="protein sequence ID" value="OXR42986"/>
        <property type="gene ID" value="B7C42_04872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="26376" checksum="C456FAE66FEB0464" modified="2017-10-25" version="1">MFAERGYHAVSVREISEQVGLTKTAVLYHFSSKIDIVVALVEPLLADTEAMLESVRTIRNPDARRWAVAEGLLDTWLRHRSLLRIHMQDQALSADTATYRRLRDIALTAQGLLAGLDADFTSQVRAAQIYAALSDPVVFFADRPEKQLRAAILDGVHRLLGGLPPRDTARTPERPVTTSQPRTARGRPGAMTPEMVESARHMRDSGEYTVDQIAATLSVSRATVYRNLTTSNDRPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2H0</accession>
    <name>A0A231H2H0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43045">
        <property type="protein sequence ID" value="OXR43045"/>
        <property type="gene ID" value="B7C42_04931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="14585" checksum="6EE2CD933C056291" modified="2017-10-25" version="1">MRAYGIELFDRWTAMWNGELELASRIMAPRFTLRYAQPGAEAYDAIHDPETFARQIAAFRAAAPGQRFETQGEAVVEIDDRGTGTVARPYGSRRPVADGEIAVSGTDILRVEDGLIVEVWSVSGGIQGRSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H333</accession>
    <name>A0A231H333_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mycofactocin biosynthesis transcriptional regulator MftR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mftR_3</name>
        <name evidence="6" type="ORF">B7C42_04634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909018.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43212">
        <property type="protein sequence ID" value="OXR43212"/>
        <property type="gene ID" value="B7C42_04634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="254"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="444" mass="49279" checksum="C3A15955D3BE7CC4" modified="2017-10-25" version="1">MSENRILRRASYGPSSPEIGTRGTTTRRKIVDVSLVLFGELGFFNTSVDAIAKAAGVSRATLYQYFPGKDEIFLELMDECGSALLRVTRRIGPLGPTPTGFDNLNWWLGEWSWVFERYSTMFVQWANVAATESVVQPEIDRFVGKYQHQLANRLADAELDGLDPEFAAMAMMAVVHRVNLYLHTDRAHGRSIESVVDALSVFLQLVFFPDTPANVFDTLPLRVDSAQVITIPPIPSARGITIEERTRDLSTRARRTVERLVAAGAAQFAARGYHRANVDDIVAAAGYARGTFYKYFNEKQDLLLTVSAEAGATAITLGDELRHLRPPAADPAAFRGWLSRFVEFEAEFGGVIDVWTERGTEQSLVADLGAYGEAMTDSAILDFLSTVDRPDIPFDPIASVLIFRAIMERLARASQEIETPLDPEQIVDLMSAVIERGFFSRARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3D4</accession>
    <name>A0A231H3D4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-ketoglutarate-dependent sulfate ester dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43393">
        <property type="protein sequence ID" value="OXR43393"/>
        <property type="gene ID" value="B7C42_04260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="34201" checksum="B20FED6FC2ED75F7" modified="2017-10-25" version="1">MSVDEATDTAVRVVRLGNHIGARIEGVRLGGSLDTDTVATIRAALHRHKVIFFRGQDHLTEDGQYEFAQLLGTPTTPHPTLASAGVKSLAIDSQHGRSNVWHTDVTFVDRVPKTSILRAVSLPSYGGSTTWASTVAAYDSLPQPLRVLAESLRARHTNRYDYAAEADDRPDAGTRSYRTEFESRYFETEHPVVHVHPETGERALLLGCFVKEIVGLSTAESRALFRLFQDRVTRLEHTTRWDWAPGDVAIWDNHATQHYAIDDYDGAEHRRLTRITLAGAVPVGVDGRPSTVISGDAAAYSRPQSLPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3G8</accession>
    <name>A0A231H3G8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Organic hydroperoxide resistance protein OhrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ohrB_1</name>
        <name evidence="3" type="ORF">B7C42_04310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43443">
        <property type="protein sequence ID" value="OXR43443"/>
        <property type="gene ID" value="B7C42_04310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="14690" checksum="715E37802F8B7511" modified="2017-10-25" version="1">MTDMAILYTAEALATGDGRNGHARTTDGKLDVDLATPPEMGGSGAGTNPEQLFAAGYAACFHSALRLVGKQEKADVSDSAVGAKVGIGPNDAGGFGLEVTLEVSLPHLSRDEAQALADKAHQVCPYSNATRGNIDVHVIVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3L8</accession>
    <name>A0A231H3L8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidase AmiD</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">amiD</name>
        <name evidence="2" type="ORF">B7C42_04315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43448">
        <property type="protein sequence ID" value="OXR43448"/>
        <property type="gene ID" value="B7C42_04315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="472" mass="48869" checksum="66F1A40B24FEDFCA" modified="2017-10-25" version="1">MTLADPPVLSGLTEAAAALRSGETTATRLVEQALAAADAHDATLGVYLSRFDERAVAQAARIDEKLAAGVPLGPLAGIPVGIKDILAHSAAPTTAQSLVLDPGWGAAQGDCTVVRRLEEAGAVVTGKVTTMEFAIGLPDPAKPFPVPRNPWDPSRWAGGSSSGSGSGVAAGMFLGAVGTDTAGSIRIPAAFNGITGLKPTFGRVPKSGVVPLGYTLDHPGPMARSAADCALLLSVLAGYDPADPYSAHTPVDDYPGALTGDLTGLTIGVDTLDRFADGGIDPAQPQRFSDAVSVLAAAGARIVPVEVPMYRELTAVDVVVMLAEAHAYHRPALRERWADYGQATRIILAGGDAVGGPDYVQAQRVRRIGRQRMAELLTKVDLVVTPTGHLGAPAIADLDQLQPMGVLSSLHTPYWNPLGNPTLALPIGTTADGLPLSMSVSGNHFAEATVLRAGDAYQRRTTHHTEIPTALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M0</accession>
    <name>A0A231H3M0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AP-4-A phosphorylase</fullName>
            <ecNumber evidence="6">2.7.7.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.53" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779307.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43457">
        <property type="protein sequence ID" value="OXR43457"/>
        <property type="gene ID" value="B7C42_04324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HIT" evidence="5">
        <location>
            <begin position="71"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="165"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="212" mass="23154" checksum="0C54520C8E130468" modified="2017-10-25" version="1">MVEEAVTQQDPGRIVDTGAGDPDRLQRLWTPYRMSYITGAVAADRDSRNGPAEADAPAGAEEKTSAGLKHPFTEIPKMSDEDGLVIARGEWVFAVLNLYPYNPGHMMVVPYRRVADLEDLTPEESAELMAFTQRAIRVMKKVSRPEGFNVGLNLGGVAGGSLADHLHQHIVPRWGGDANFITVVGGVKVMPQLLRETRALLAGAWHEAKEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3N3</accession>
    <name>A0A231H3N3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.345</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pimA</name>
        <name evidence="4" type="ORF">B7C42_04327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.345" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43460">
        <property type="protein sequence ID" value="OXR43460"/>
        <property type="gene ID" value="B7C42_04327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043750">
        <property type="term" value="F:phosphatidylinositol alpha-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="374" mass="40088" checksum="4A77968E36FEFFF2" modified="2017-10-25" version="1">MRIGMVCPYSFDVPGGVQSHVVELAQVLIERGHKVSVLAPASDDTELPEFVVSAGKAVAIPYNGSVARLSFGPTAYTRLRRWIADSDFEVLHVHEPNAPSISMLALKVAEGPIVATFHTSTTRSLVLATFQGVLRPYHEKISGRIAVSELARRWQVEALGSDAVEIPNGVDVPAFANAPLLQGYPRAGGTVLFLGRYDEPRKGMAVLLGALPKLVARHPDVEILIVGRGDEERLRREAGEHAGHLRFLGQVSDAEKASAMRSADVYCAPNLGGESFGIVLVEAMAAGTAVVASELDAFRRVLRDGTAGVLVPVGDSAALAEAIDGLLTDRTRREDLVRTADQVVGEYDWPVVAEQILRVYETVTVGDARVRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3R1</accession>
    <name>A0A231H3R1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43490">
        <property type="protein sequence ID" value="OXR43490"/>
        <property type="gene ID" value="B7C42_04357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646862" evidence="1">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="14310" checksum="9EE35EBCE2D650D0" modified="2017-10-25" version="1">MSRSRRTRIGAALAGAVGVAFVVGGATAAATPSVALRGGATITARVTGEKAGQACRITGSGIDMPWRTVGSDGSVELDSGPVPSGRHNARVVCRDPRTGAASQHAVGKEEDVFTGHWAPAFEFLHHHRMEFLTPHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4L3</accession>
    <name>A0A231H4L3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal-transduction histidine kinase senX3</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">senX3_1</name>
        <name evidence="6" type="ORF">B7C42_04005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43770">
        <property type="protein sequence ID" value="OXR43770"/>
        <property type="gene ID" value="B7C42_04005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="182"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="438" mass="46898" checksum="4985CD211439FF98" modified="2017-10-25" version="1">MTCAKLRQPGFGVRVRDRTILYVSVPQAVLLAVLAAVVGLAVGGLVIPYMNARQAERRAAESGLTMSQVLDLIVLASESGIAVVDEYRDVVLVNPRAEELGLVRNRLLDERAWAAVEKVIATGEDVEFDQTLKNPLPGRNSIAVRGVARPLSRGDSNFVVLFADDDSEQARMEATRRDFVANVSHELKTPVGAMSLLAEAMLESADDPDSVRHFGQRLVSESNRMGKMVTELIALSRLQGAEKLPQLEAVDVDTVVNAAIERSRTAAEAAGITVSTDANSGLEILGDETLLVTALSNLVENAINYSPKGSHVSVSRSLRNGHVNIAVTDRGIGIAKEDQERVFERFFRADKARSRATGGTGLGLAIVKHVAANHNGEITLWSKLGTGSTFTLRIPAVESGNQNSAAPAERKSPTAIGVGKNDDGPRRRTGQNGVEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4X6</accession>
    <name>A0A231H4X6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein LprB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lprB_2</name>
        <name evidence="1" type="ORF">B7C42_04153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781054.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43914">
        <property type="protein sequence ID" value="OXR43914"/>
        <property type="gene ID" value="B7C42_04153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="176" mass="18150" checksum="3EB1BB612D68B894" modified="2017-10-25" version="1">MRLTAAIVTGTALAALLAGCGSGDDSGSDSPSVRPPAKVAALGPFVGECGHVTDDEVRNLGGLGQISQVFKNSVGCNWQAGGIGGPSVTFASYRGSPIGREKAWVTAQGRNPESIEVGGHQGFQDASQDGTICDFAVQLGDDFFEWSTSAGAFGQMSATPCDKNRKLAELTVQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H570</accession>
    <name>A0A231H570_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783882.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44004">
        <property type="protein sequence ID" value="OXR44004"/>
        <property type="gene ID" value="B7C42_03560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011317305" description="DUF732 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="3">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="12755" checksum="AC77D121F7E36BDA" modified="2017-10-25" version="1">MNARIISSLLAAGATAAVLTAAAPASSATPDTGSASGSSGSSCGPRSSADRRFLRDYAEDDDTCSGQDASIRLAQAECNWLRAYGNSAHNQILIAEKSRGAVKYPYIFLDAAIEAYCPQYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5K1</accession>
    <name>A0A231H5K1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exoribonuclease</fullName>
            <ecNumber evidence="1">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44105">
        <property type="protein sequence ID" value="OXR44105"/>
        <property type="gene ID" value="B7C42_03661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004532">
        <property type="term" value="F:exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00977">
        <property type="entry name" value="3_5_Exoribonuc_actinobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030853">
        <property type="entry name" value="3_5_Exoribonuc_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033390">
        <property type="entry name" value="Rv2179c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16473">
        <property type="entry name" value="DUF5051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5051" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="19836" checksum="DF23964DEF2E21C3" modified="2017-10-25" version="1">MKYFYDCEFIEDGVTIDLISIGVVCEDGREYYAVSTEFDPERAGQWVRRNVLPKLPSPSSPLWRSRQRIRDDLYQFLVPRPTVRPELWAWVGAYDHVAFCQLWGSMVDLPTALPRYTNELRQHWDHHGRPDLPPVPADAHDALADARHNLAKYEAIEAFRRSGAITGIDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5N3</accession>
    <name>A0A231H5N3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative arabinosyltransferase C</fullName>
            <ecNumber evidence="17">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">embC_4</name>
        <name evidence="17" type="ORF">B7C42_03707</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the emb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="17"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44148">
        <property type="protein sequence ID" value="OXR44148"/>
        <property type="gene ID" value="B7C42_03707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052636">
        <property type="term" value="F:arabinosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071766">
        <property type="term" value="P:Actinobacterium-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032731">
        <property type="entry name" value="Arabino_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042486">
        <property type="entry name" value="Arabino_trans_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007680">
        <property type="entry name" value="Arabino_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040920">
        <property type="entry name" value="Arabino_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027451">
        <property type="entry name" value="EmbABC_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14896">
        <property type="entry name" value="Arabino_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17689">
        <property type="entry name" value="Arabino_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04602">
        <property type="entry name" value="Arabinose_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Arabino_trans_N" evidence="16">
        <location>
            <begin position="51"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Arabinose_trans" evidence="14">
        <location>
            <begin position="209"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Arabino_trans_C" evidence="15">
        <location>
            <begin position="720"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="788"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR44148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1089" mass="116964" checksum="8F5C2C455CCF1718" modified="2017-10-25" version="1">MVRADDTPAAGQGHRVDRSRLARWAQPIALIAGLLGALCAIAVPLLPVQVDHTTLSWPQQGSTRGIDAPLVSYAPLTFDATVPCAALAQLPAEGSTLAATMPSGAPDLERYGFVARVRPGTDGKPGQFEAVLRNQSLASVPVDRLGGDCAFTVHSEISHTAATFTGADVKPVTLQGDWRPQLVGVYSDLTRAAGTSVTAQVDSRFSVVPTVLKRIATVLAVAFTLIALAALFRLDRLDGRRIRRWLPQRWWSFGAVDAVVLGGLVIWHFIGSTTSDDGYQFGMARASLVSGYMANYFRFFGVPENPVGTPPYDIIAHMTEISTASPWMRIPTLLAGVVTWLALSREVIPRLGVAVRHDRVAVWTGALIFLAVWLPYNNGLRPEPVIAVCVLLTWCFVERAIATRRLLPYAIAILVAAFSFTAAPSGVICVAPLLAGMRSVFRFGSARARDLATDPRTGEHRSRWAVVYGYGSLLAPLAAAGALVLAFAFSVQPLSAMFEMRRVHTAVGPSDPWYNDYLNYQWLFMPTADGSIGRRFGMVAMWLGLLVCVFVLLRKGGRIPFTAGGPARRLLGITFASMLLMATTPTKFTHHNGVYAGLAGAVAVLTAVAVGPRVMRSPRNRALFGAVVALVMAQIFTSVNEWWYVSSYGIPWWDKPPSIHGFGLSKLFLAVAVVLLALAGWWHVRAPEPGTPHRISRSAWRWAKIPPLTVAAALLVVFEMASFAKGAVAQYPAFSLARSNMDAVLGEPCGLANDVLVETDPNASMLAPLTGDPQTTFTAGATGFVPNGVGDLTPEGEPTNSSSISSAFDSGKSQGEAGTQTAGAPLPYGLDSATTPELGTAGQQDPAELTTGWYRLPPAAERTGIVAITAAGRIRSIDKDGVVTPGQRVEIEYGASDSATAAHALGSVIPVDIGPTPSWRNLRVPFGQIPPQADVIRIVAQDSSRDPTQWVALTPPRVPRTTTLQDMVGSRSPVLLDWAVGLQFPCQRPYDHRDGIAQVPNWRILPDRTAAHDTTLWESHDGGGPLGWSQQLLSSQTLATYLKDDWRRDWGELQRLAPRDTSATAAVPTVTRETHGGMWNPGHINTAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H613</accession>
    <name>A0A231H613_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multifunctional-autoprocessing repeats-in-toxin</fullName>
            <ecNumber evidence="2">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rtxA</name>
        <name evidence="2" type="ORF">B7C42_03839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777623.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44278">
        <property type="protein sequence ID" value="OXR44278"/>
        <property type="gene ID" value="B7C42_03839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="53"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="28409" checksum="625631248E4F9BBB" modified="2017-10-25" version="1">MRHPAEGVLNALTFHPERRITMTPEQFGFDHDDLWLTADDGSRINAWFVRAEKPIAHVLYAHGNGGNIGDRSPILALLAAAGLNVLTFDYRGYGRSPGRPSERGLYLDARAARRALLEQSGVDPKRVVYLGKSLGGAVVTELATEYPPAAMVLMSTFTGLREAARAVYPFIPKPLVPNAFPTLQRLRDLRVPTFVMHGEADELLPVEMGRTLYAALAEPKRLLIYPNAGHNTLVSIPGWSGTVSAWVRDVLAGVESVTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H662</accession>
    <name>A0A231H662_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein B7C42_03886</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44325">
        <property type="protein sequence ID" value="OXR44325"/>
        <property type="gene ID" value="B7C42_03886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="73" mass="7873" checksum="FC0A58FCD2AE5897" modified="2017-10-25" version="1">MAEQTLDPTLLSLLACPEDKGPLSLVRDADGNSVLYNPRLRRAYPVDNGIPVLLVDEARPVGDAEHEAFTAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6E5</accession>
    <name>A0A231H6E5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent Clp protease ATP-binding subunit ClpC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">clpC1_2</name>
        <name evidence="9" type="ORF">B7C42_03214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775717.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44425">
        <property type="protein sequence ID" value="OXR44425"/>
        <property type="gene ID" value="B7C42_03214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="849" mass="93851" checksum="5AF6961AD8D6870C" modified="2017-10-25" version="1">MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVRSQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYQGGKEAVESGARGESGTPSTSLVLDQFGRNLTQAALEGKLDPVIGRSKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVNGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTINILKGLRDRYEAHHRVSITDGALVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPDLREFDDKIADARREKESAIDAQDFEKAARLRDKEKQLVAKRAEREKQWRSGDLDVVAEVDDEQIAEVLANWTGIPVFKLTEEETTRLLRMEDELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNTLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKAVGLGFSQSNAEGSNYERMKLKVNDELKKHFRPEFLNRIDDVIVFHQLTNEQIVEMVDLMINRVATQLRNKDMEIELTEKAKSLLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFGELGPGQIVEVDVENWDGEGAGEEAKFTFAGKAKPAKAEAEPVAALAGAGEATPEASGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H732</accession>
    <name>A0A231H732_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold shock-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">csp</name>
        <name evidence="3" type="ORF">B7C42_03452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776154.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44658">
        <property type="protein sequence ID" value="OXR44658"/>
        <property type="gene ID" value="B7C42_03452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15783" checksum="CB7F19548336E473" modified="2017-10-25" version="1">MPTGKVKWYDVDKGFGFLSQDEGEDVYVRSSALPKGVDALKPGQRVEFGMAAGRRGPQALSLKLLEPLPSVRTAQGRNDRVRKEAPAHPRKAPDDLHGMIEDMITLLEATVQPELRKGKYPDRKTAQRIAEVVRGVARELDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7B3</accession>
    <name>A0A231H7B3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44824">
        <property type="protein sequence ID" value="OXR44824"/>
        <property type="gene ID" value="B7C42_02778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="125" mass="13746" checksum="EC7F3192350A4D9B" modified="2017-10-25" version="1">MAHSDDVTLWQHLAEESKAGRLDLDPSVAQDCLKACEDQLNVYRECRGMLQDMKTVTGLGDFPAADQLAKMLGAKAIGGEGDFDTAFRDHIEVLQLIRDTIKHSVDRLVDHDQQNAGTIAGSENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7E4</accession>
    <name>A0A231H7E4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776217.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44677">
        <property type="protein sequence ID" value="OXR44677"/>
        <property type="gene ID" value="B7C42_03471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="243" mass="26704" checksum="DBDEED5A7C5FEC1F" modified="2017-10-25" version="1">MPSTASSIWYVDDPDPAAVLRSHPDPDPEAALALAKQLNPDHDVVPAASGTLKVWAGPDPGSMYIGCFPGVTVVCTVQAARSHPTRLPELLIRPLASEHTYLVSYDVPLGWGAFAHWERGEFRRAFSATRVDIVEDEGLPLVWERPYWAGDHPVRLRPGDFPDPQILPFDPPEFADAANEEWLGFRYRAGAGGDALLPDRIEVCGFSLYPAGQAPAPATRETSVTIPASKRWFGWLRGRDRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7H3</accession>
    <name>A0A231H7H3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44676">
        <property type="protein sequence ID" value="OXR44676"/>
        <property type="gene ID" value="B7C42_03470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="38114" checksum="A1BA2000CA0948B2" modified="2017-10-25" version="1">MRELRVIGLTPDSAHIVCVDAETGQKYRLAADEKLRAAARGDLARFGQIEIETEATMRPRDIQARIRAGASVEQVTEESGMPASRVERFAYPVLLERARAAELAQKAHPVRKDGPAVETLIEIVSAAFAERGHNIDIAEWDAWKDEKNYWVAQLQWQAGRSVIAAHWRYQPDAHGGSVVPLDDPASDLIDPDFGRALRGLATILPEPTPEPAPVVEPVSAGPVQTTAVAETGEAGFDEYFEQRAAVGGTAVPVSAKSTVAANPPSTTAPAAPTTPALPAAPAAAAPTAPAEPSEPSVPAAPAAEPEPAVAAEPESAPAAKSAPAAANAKPESKPAAQKTARAKRGKAPMPSWEDVLLGVRSSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7K1</accession>
    <name>A0A231H7K1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cph1</name>
        <name evidence="10" type="ORF">B7C42_02960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45003">
        <property type="protein sequence ID" value="OXR45003"/>
        <property type="gene ID" value="B7C42_02960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="305"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="537" mass="58498" checksum="966AE5C59BEF734D" modified="2017-10-25" version="1">MNDVRHREGIVGRLTAQTWFQLVLALMLVVVIAGAIAAAQMISRTDSIEDRLLDRAQPAATEAYRLQAALINQETGLRGYAISADEQFLQPYNKGVTDEAAAAGRLREVAAGHTTLLGDLDAVEAAAQRWRTEYVQPMIAAAGKVSPAESAAMVTRGKALFDEIRTKFATQNADSAAAIAQDRHDLDNARTLRDGVLIAVVVLILLTGLALTVLIRRLVARPLDELTEASRRVSAGEFDHHIAAHGPADLATVAEAVEEMRVRIVSELGSSRAQEDLLARQADDLDRQTVQLRRSNAELEQFAYVASHDLQEPLRKVAAFCQLLEKRYGDQLDERAKQYIDYAVDGAKRMQRLINDLLTFSRVGRVIEGNEMVALDAALNSALDNLSGAIEDSGAVIERPEQLPDVAGQPTLLTMLWQNLIGNAVKFRSPGTAPVVRIECEPGDEPGEWRFSVSDNGIGIAPEFADKVFVIFQRLHNREDYGGTGIGLALCKKIVEYHGGDLWIDTEYTGGARFRFTLATEAAAPALIEPVSEGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7L8</accession>
    <name>A0A231H7L8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44780">
        <property type="protein sequence ID" value="OXR44780"/>
        <property type="gene ID" value="B7C42_02734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="33077" checksum="DCB99FD458FDB2CE" modified="2017-10-25" version="1">MNAPVSVADQALQPLIDWATAELGNLGRTVTGAQEMRRRDWTLLARIDTDAGAVWAKASARAFAHEGPLLEAVDRLVPDAVPKPLAVHRENGWFLALDGGETMRTGPLDRQFALDGSDAPPPRPPGWESVLRSYAALQHTLCTHAESLRDTGTPYLPPARLIDVYRHFAERAPRLESAIESAAAELARYDRLSVEHNDLYPGHVFRTTAAVFDWGDALITHPFLSVRTFRDPQRAAYFDAWRELATVTDREIELAERLAPLTTLHSWLTIDTAPGRPAERFAPFVTEMLDRLRANFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H819</accession>
    <name>A0A231H819_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigF_2</name>
        <name evidence="8" type="ORF">B7C42_02956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44999">
        <property type="protein sequence ID" value="OXR44999"/>
        <property type="gene ID" value="B7C42_02956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="29721" checksum="C7C7B2A4ADAF3A4D" modified="2017-10-25" version="1">MSTENGSGTTRHPDGYDDVAPLFVELAALPEDDPEYDRLRERIINRCLPLAEHIARKFSGRGENFEDLLQIARVGLVAAVDRFDPTQGSPFLAFAVPTVMGEVRRHFRDHTWALRVPRRIKEIQTALGPTVETLSQRLGRMPRAREIAEEMDADLGEVTQALIARNAYQTQSLDTPTSEDDSRSGNAILDTLGAVDPTFGAIDDTLTVKPLIDALPEKERYVLTMRFFGGMTQEQIARELGCSQMQVSRILTRTLKQLREKALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8B1</accession>
    <name>A0A231H8B1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator BenM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">benM_1</name>
        <name evidence="3" type="ORF">B7C42_02979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779983.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45022">
        <property type="protein sequence ID" value="OXR45022"/>
        <property type="gene ID" value="B7C42_02979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="31052" checksum="4237D686B45B8D24" modified="2017-10-25" version="1">MELRQLTYFVAVCEELSFSRAAVRCFISQSAISHQIARLEHDLGVQLFERSTRSVVPTEATIRLLPLAKQMLSLESAIRAAVRDSGPRIRLAANMSFATRSLSAIAGAREAHPGAEIEFVIKPFRQRIAAVADGDCDLALIRGSVEQPGLTVEQLWVEDLVIAASTAHPLAGRGDVTLTELGKYPLLLPPETEQVLLHNVVRHAFAELPTRPSYGPPIPPDHTATMELINRPDAWTILYADSATEGIATLKLAGRPLRIPVSAVIRSDIRRSPILVTLLAALHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8C0</accession>
    <name>A0A231H8C0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">msrA</name>
        <name evidence="6" type="ORF">B7C42_02954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44997">
        <property type="protein sequence ID" value="OXR44997"/>
        <property type="gene ID" value="B7C42_02954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="19323" checksum="D47502FB6691BDAB" modified="2017-10-25" version="1">MTDTRTAILAGGCFWGMEELIRKQPGVISTRVGYTGGRNDHPTYRNHPGHAEAVEIVYDPARTDYRALLEFFFQIHDPSTKDRQGNDIGSSYRSAIFYLDDDQKAIALDTIADVDASGLWPGKVVTEVTPASEFWEAEPEHQDYLQRYPNGYTCHFPRPGWKLPKRAATSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8F2</accession>
    <name>A0A231H8F2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45115">
        <property type="protein sequence ID" value="OXR45115"/>
        <property type="gene ID" value="B7C42_03072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="129"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="41197" checksum="F12BE131B55172C1" modified="2017-10-25" version="1">MTRSQRRTSRRGLVTAVATVTTLGISGCGLTLENVPMPKPGIGGPGYTVHAAFTDVLNLPDHAHVRIGGTDIGTVTGIETTNFVADVRMQIRSDIVLPRGTTVELRQATPLGDMSVAMTLPSAQEAGPPLRDGDTIGVEHTGTAASVEQLMMSVAMLVNGGGINQAAQITTQMNSMFAGRGPQLAHLLSEMTGVIAALNQRTGDIDATLQGLNTLSGELTRRKKELGAAADTFPQLLGLVNENNQRIVDLTTKVSTTMAALGDFTDTTSPQFLSLFDSIQKLMSGFTEMGGNLTEALNGLNDIYPPLMASLRGSGLAVMPVVSYLSIGALSDPHGSRWPEIGDVPAFAGSLAQVFEKVFGRVISPPQPVPGTTPPGANPPAAPGAPAEPSQPGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8H1</accession>
    <name>A0A231H8H1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xerC_3</name>
        <name evidence="5" type="ORF">B7C42_03129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45171">
        <property type="protein sequence ID" value="OXR45171"/>
        <property type="gene ID" value="B7C42_03129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="192"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="422" mass="47165" checksum="935E0DE10EC482AE" modified="2017-10-25" version="1">MARQSLAIGTYGTISCTKVGPRQYRARARYRARNGETIPVEGWGTSKSGAEARLKQIVRERMEKDGTQRAGAIKRDTLMSELANRWLAEMELDETIAPQTIQWYREEIEPSSDPRANKDTVKIKSAMSGVRVFEADTSFLDAYLKRIQANGHRRKAQTHKIILTGMMSLAVRHGAIRENPMREVGRIKRKKVKPHAMNEATRNGLRAQLETWLAGKEIPGTPAYTHGPARDPAVLNIADILLGTGARPGEGLAFRRCDLNRHATPWELTICGTIVRVTGKGLYRQEWPKTAAGYRVVVLPQFTVNALKEMGADEWDPADESPIFPSRRGGWRDPHNFGRTWRTARGTTYAWVTPKTYRKTNLTVVAEEFGPEQAKQQAGHRHSSTTQEHYIDKPAKAPDSTAALNHLAPKFSNAVGTGRPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9C0</accession>
    <name>A0A231H9C0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative niacin/nicotinamide transporter NaiP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">naiP</name>
        <name evidence="7" type="ORF">B7C42_02580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776545.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45455">
        <property type="protein sequence ID" value="OXR45455"/>
        <property type="gene ID" value="B7C42_02580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="422" mass="45490" checksum="44DE56C4EE739260" modified="2017-10-25" version="1">MAITAGDDPRAARLDELPVRPVHRKLVALVGLGLFFDLYELFLAGTITGVLKQQLALSTYQLSGILASAFVGQFLGALVIGRLSDLFGRRRMFMINIGVYAGFTLLGAFSPNVWFLMATRVLAGLGIGAEMTVSDTYLSEVMPPQVRGRMIAIAYTIGFCAVPTVGFLARWLVPLQPFGTDGWRWLFIFGGFGAALVFVARRHMPESPHWRAQHDKAATTSSKVAFTDILRGANRGRTLLFSAVMILQVFGYYGFGTLAVLVLQHKGFTVVNSLGYLTVTYLGYPLGSLLSIPLIERVERKYLVMASAALMALFGLIFGFATSVPLILLSGGLFTLASNVFSNALHTYLPESFPTTVRGTASGTAYSLSKLSTAVQPFLLLPLLDSHGPGTVFTVITIALVLMLGLIAAWGPLTGRGPLADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9N3</accession>
    <name>A0A231H9N3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative antitoxin YwqK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ywqK</name>
        <name evidence="1" type="ORF">B7C42_02532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45407">
        <property type="protein sequence ID" value="OXR45407"/>
        <property type="gene ID" value="B7C42_02532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="13331" checksum="D96936DD745067D9" modified="2017-10-25" version="1">MNRIDINVDPITWGEDLRLEYRGELYSGEVVEMLGDQLLSQEFYVNGIRHGPSRKWWADGRMMSEGEMIAGRPSGVFRKWHPNGRVAEEVHFDGNGMLVARYRWDEDGNYIRGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9W4</accession>
    <name>A0A231H9W4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein HsrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hsrA_1</name>
        <name evidence="7" type="ORF">B7C42_01931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45639">
        <property type="protein sequence ID" value="OXR45639"/>
        <property type="gene ID" value="B7C42_01931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="505" mass="52267" checksum="A9CE53F0E1C5EF94" modified="2017-10-25" version="1">MASTTAQQSGKLDRSVIVTGLVVVSGMIMVVLDTTIVNVALNSLSTELGATLSTTQWVVTGYLLAVALVIPVTGWAMDRFGPRPVWLTAVSLFVAGSALCAAAWSIDSLIAFRILQGLGGGMLLPAGQAIITRAAGPQRLGRAMAILGVPMLLGPVFGPVIGGLLVQYTSWHWIFLVNVPVGALALTLAAWKLPHGDTLPEHGRLDLLGLILLSGSLVCLLYGLSEASSHGGFTEWGVLGWLIGGVAGLALYTWHSLRKGADSIVDVRLLTNRLFASGTIAVFLVAIGLFGGMLLLPLYYQTVRGHGPLDAGLLLAPQGLGAIVAVVIGGRLTDRIGAGYVVPVGVVLGLIGTLPFTHVGTDTSYVWLCVALFVRGMGLGAVMMPTISAAYTELGKDAVTRAAPTLSAIQQVGASLGSALLVTALTQHLSRQLTECGIPSGSGGSGQISSVPPRLMPVVGPLLADSFGFAFWVAFGLTAVIIIPAMFLPRHAAREPEETPVAPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAE7</accession>
    <name>A0A231HAE7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45840">
        <property type="protein sequence ID" value="OXR45840"/>
        <property type="gene ID" value="B7C42_02132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="251"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="386" mass="40520" checksum="E8CB0AD860E211A0" modified="2017-10-25" version="1">MRRVALVGAGMTPFAEHFALGIKDLLPMAFAECAASVDKGIAKADLQAAWFGAMGTPDGFPSGILADVLGVPDLPVTRIENSCATGNDAVRNALFGIASGACDVALVIGADKLRETASKDMLWEWEAMTRDMAWDYPLGLIAPAGFALHVARYLHESPAGREHLGMIAVKNHRHGVSNPKARLRFEISLEQALAAPAVVDPFGVYDCAPQSDGAAALILAAEDAVDRYTDRPVWIRGVGLGLDSVMHQHKRDMTTFPATVRAAKQAFAMAGLTPADIDVAEVHDFFTGIELISYEDLGFADRFEACKLVDTGATSVGGALPVNPSGGLKSKGHPPGATGVAQCVELFEQLRGHAVNQVDGARIGLAHNLGGPTAVSAVTILEGPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAG7</accession>
    <name>A0A231HAG7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783455.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45841">
        <property type="protein sequence ID" value="OXR45841"/>
        <property type="gene ID" value="B7C42_02133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13803" checksum="51AFD8350BA1F19D" modified="2017-10-25" version="1">MSARCESEVVALVTGRVARRRVVLDWAAHYVGRDGTVHVVCDGTLAPALVSSIMVGMFVDAEQVEHADFAQTAMLLSPHGCNWTWQHLPFGAVGHAVALARRKNLLAVVPARSQLLRPPSVRIVCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAI2</accession>
    <name>A0A231HAI2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45822">
        <property type="protein sequence ID" value="OXR45822"/>
        <property type="gene ID" value="B7C42_02114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019919">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03617">
        <property type="entry name" value="F420_MSMEG_2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="36380" checksum="AF949EC55AD55E23" modified="2017-10-25" version="1">MRIDTTIGALDDAAARVRALEHLGFDGIWAGEMNGDPFLSLAVAAQCSERIGLGTSVAVALARSPMTVAYAADDLHRFSGGRLRLGLGSQVRAHIERRFAMPADRPAARMREYVLALRAVWAHWHQGSELAFEGEFTRHTLMPRDFVPPAHEFGPPPILLAGVGPAMTRVAAEVADGFICHGFTTARWIRERTLPALGAAAKRDDFEVVATPFVVTGTDEQIERGIATLRRRLAFYASTPAYRPLFDLHGWGEVNAELTALSKAGRWDRMAELITDDMVDAFAVVAAVRELPERLAARFGGLLTRLSFAPPRDMPADEVADLVRRIRRACDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB26</accession>
    <name>A0A231HB26_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46134">
        <property type="protein sequence ID" value="OXR46134"/>
        <property type="gene ID" value="B7C42_01099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="28789" checksum="9C9C643AD32A9F02" modified="2017-10-25" version="1">MTDSPSDSGASRLPGATRPVALVTGPTSGIGQGYATRLASLGYDLVLVARDEQRLSALATELRHRFDTRSEILAADLARSHDRDTVADRLGAGVDFLVNNAGFGISGEFWTVEPRELQAQLDVNVTAVLQLTRAALPPMIAAAKGSVVNVASVAGLVPGRGSTYSASKAYVISLTEGLAGGLAGTGVRVQALCPGFVHTEFHERAGIEMSSLPKPLWLDVEQVVSGSLQDLEKDRVISVPGVQYKALTTVAGLIPRNLVTRLNRGMFNARGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB38</accession>
    <name>A0A231HB38_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46049">
        <property type="protein sequence ID" value="OXR46049"/>
        <property type="gene ID" value="B7C42_01012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375773" description="LytR_C domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="84"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="16889" checksum="4C3CD2CCB4E00A44" modified="2017-10-25" version="1">MVLIALAIVFAGLGAMALSNSTSDSAAAETSSDTETTAVPVTTTRAAATTPSTTAATTTAAPATTLTTTTAAPTSTAAGVDKTVPVRVLNNSTVAGLASKTGSQLTAAGFDVTETGNYPGGVIAKTTVYYGNSPHERETAQAIANELGVSAEPRFAGIADSPPGVIVIVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB56</accession>
    <name>A0A231HB56_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46173">
        <property type="protein sequence ID" value="OXR46173"/>
        <property type="gene ID" value="B7C42_01138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="9602" checksum="324C931A8E2FC14C" modified="2017-10-25" version="1">MTTRITEVRGLRATWRHGRDGIEIIDVRGAFGEAEDSFPPGTDLAAARELRPDLGDLWDVVRREFWDHYLAARVVRDEPGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB66</accession>
    <name>A0A231HB66_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter glutamine-binding protein GlnH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnH_2</name>
        <name evidence="5" type="ORF">B7C42_01052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46088">
        <property type="protein sequence ID" value="OXR46088"/>
        <property type="gene ID" value="B7C42_01052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280090" evidence="3">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="87"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="34097" checksum="9C1E7ED087B941F3" modified="2017-10-25" version="1">MRARRAAAAALAASALLAGGCGGAPSTPRAGGSGTYTEPPLPANAVVTQPQSAPAPDLEPQCGNPTASLRPGADHGPALDAVRARGRLLVGLDPGSNLFSFRDPISGTLAGFDVDVAAEIARDLFGDPRRIEYRILGSADRERALQDHSVDVVVKTMTITCDRRRRVDFSTTYLMSHQRVLAVKGSGITSMADLAGKRVCAVGGTTSLDRIRHIQPTAAIMTVPTWADCLVVLQQRQVDAISTDDALLAGLAAQDPYAEVVGPALSDEPYGVGVPKGNDDMVRFVNATLQRLRTDGTWDRLYQHWLAPALGPAAGPPEPTYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBG0</accession>
    <name>A0A231HBG0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator YtcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ytcD_2</name>
        <name evidence="3" type="ORF">B7C42_01166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46201">
        <property type="protein sequence ID" value="OXR46201"/>
        <property type="gene ID" value="B7C42_01166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022402">
        <property type="entry name" value="F420_OxRdatse_MSMEG3544_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03854">
        <property type="entry name" value="F420_MSMEG_3544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="440" mass="47096" checksum="F8BC66A25276F4B9" modified="2017-10-25" version="1">MTEQEQAAAVARRIFATLSTKWALAVLEAIGDHERRFAELHRAVEGISYKMLTQTLRTLEADGIVVRYDHHTANPRVDYSLTPAGRDLLATVHQLCTWSRTHLRELLAESHAAQQDRHDHTGAPDGGGAGPEISVRQRLLCRVVSNGEVKIRFGVGTGSAADPDDLAALVDRLEAARVDSLWFSELVFAPAVDPTVGMAFALARTSRLKVGTSVAILPGRHPVLVAKQLASLAALAPKRVLPVFGLQPAGPGEKELFPVPGPRGAVFDESLRLLRAVLRADDVDFDGDYFTVRAATVGKRPARPLDIWLGGRAPGAFRRIGRYGDGWLGSFVTPAEASAGVTAINAAAAAAGREIEADHFGITLLLAENGIPAELAARIRAQRPGADPGDVIAGSWADLHRLVDGYLAAGLSKFVVVPADGTVSARFVDRFVTELLPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBH5</accession>
    <name>A0A231HBH5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46169">
        <property type="protein sequence ID" value="OXR46169"/>
        <property type="gene ID" value="B7C42_01134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="18833" checksum="81F69C3CCCBAF289" modified="2017-10-25" version="1">MLAAARDLLTDRGLPGLSVDEIATHAGVSKNTIYRWWPTKAAVLMDAFTDAFADRMSVPAEGDALTRLRTTVRRVATLMSDPDARRPFVALVAAAQHDPELAAALRDRFIAGRRAEVGELLADARSTGSLPAGFDPDTAIDLIYGALYYRLLISGESVDSGYADRILTAMGLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBL7</accession>
    <name>A0A231HBL7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl-CoA hydratase echA8</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">echA8_3</name>
        <name evidence="2" type="ORF">B7C42_01178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781503.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46212">
        <property type="protein sequence ID" value="OXR46212"/>
        <property type="gene ID" value="B7C42_01178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="27423" checksum="EE84C4337084C35B" modified="2017-10-25" version="1">MATAEYQHLLVERNGETVRITMNRPDRRNALSAEHLRELSSAFRWAGGSDASGIVLAANGPVFSAGHDFADVAARDLLGVRELLTLCTEVMSAVESVPQVVVARVHGLATAAGCQLVASCDLAVAAESAGFALPGGKGGWFCHTPAVPVARAIGRKRLMELALTGDPIDARTAADWGLINRAVPDADLDRAVADLLTRATRGSRASKALGKRTLYAQLDRPEDDAYAIALEVMAAASQLPGAREGMDAFLNKRTPIWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBQ2</accession>
    <name>A0A231HBQ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trehalose monomycolate exporter MmpL3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmpL3_1</name>
        <name evidence="9" type="ORF">B7C42_01231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46265">
        <property type="protein sequence ID" value="OXR46265"/>
        <property type="gene ID" value="B7C42_01231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="45"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="479"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="739"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1097"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1152"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1307"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1336"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1376" mass="144128" checksum="642AB29D923DB811" modified="2017-10-25" version="1">MFTRWGELVHKFRYTVLGVAVAALLALGAYGFGLENHLSTSGWFDPGAESSQAAVLKDEVYGRDHMSDVIALYTAPEGKTIDDPEFGRKITENLNSLPREHPDRISKVNVAYWKTETGDWSASATGSKDKKYAFASVAIKGDDDTTTMNNYRAVKDAFYIPGVDVQLAGMQPVAGTLNDTIASDQKRMEMLAIPAVAVLLFFIFGGIVAAALPLIIGGLTVLGANGIVMAITHVTEVNSFVGAVVSMIGLGLAIDYGLFIVSRFREELAEGYTTRQAVRRSVMTAGRTVTFSATMIIAASAGMLLFPQGFLKSVAYGTIATVLLAALASLTILPALLSILGPRVDALGFKRFRKTKTAEEVENGFWGRTTQWVMKHPLKVAVPLCIILLLLIIPVKNLKFGGISETYLPPDNPTRMAQEKFDEIFPLRQTDPIQLVITTQNTSEIKAILDEASGAPGLTDPFGTPGIPPNGSDVWVSEATMAPDANVEDTIAYLRSIHVPDDVDLMVGGQPVLMQDSIDSLLDRMPLMIVLVVFVTTLLMFLTFGSLVLPIKAALMSALGLGSTLGILTWIFVDGHGAGLLNFTPQPIMSPVLVLIMAVIYGLSTDYEVFLLSRMVETRAQGASTTESVRSGTAQTGRIITAAALILLVVVGAFAFSDLVMMQYIAYGMMAALFIDATVLRMLLVPATMKLLGDDCWWAPAWMKRIQQRIGLGEPILDDERPGTGEVVDLVKTTPVTDPVTMQLPQLPDGAPKGPRKPRRLKFLRVDPEAPTEQLDRIDPAATGTSTRATRAKSPTPRAESPAQSRADRPRAESSEPSRAAGTASSAARSGGPTVRTGEPAEPPAADAVAASAAGTQKSDSSASEQPGRTEKPEKSGKAEKSPKRKRFGIRRSDSGADAPSADSGNASPADHADDAADDAANQAPPAASSSADAAAAHTPAGPEGGRSSTPPQTPGIRSPRVLPPPARPQPPRASGGSGVIGAGPSAADEAGRAAGTSEPARSADVGGTSGVLGAAPLPGRAAPNPGQPPSRTPEPPAQQAPSAPPSVSLPGSDTAPNRGVVRPPQVVRPGMPPRTVPAPDTAPDATDSVPPTAPVGTTPRVLPPKPSKVPPHPSVRAQLYRPDAPPYHPEQPPAQGPGQTPDAGRPGHSGPPDGPGHPANPPQGTPGASAPTGHGAGWSEPAGRPQQGPDPSQRVAPEGRPPAVQPPRRVPTDGMRRSPTRTPESGPGGVPPGMPREPRDAEATQELHEPANPGNRPPAGGHNAPAPGSRGDLGSAMPPGPQRTTSDAGEAGASTAPERENPTPAAESDASGNPSDHTAGPGGDNRNNIEQWMADLRSSRRRPEPEPADPDDEGKHRTSGRTVSVNELLRRQNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBS8</accession>
    <name>A0A231HBS8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46206">
        <property type="protein sequence ID" value="OXR46206"/>
        <property type="gene ID" value="B7C42_01171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="39615" checksum="D7049E98A2A7EF7E" modified="2017-10-25" version="1">MTRCAHYVGSVPAELMTGDAAVLQWFADRSAGHPVTGLPCDLDPDWILDYLRRRREHEDVFEVVRTGDYSDYSDFPSYGLRPGAKLEPRHVAMDRLDRIGAVVAAFDEVRAGRPELDGTRLQLSQPNPLDLAMFVFAGAAVSNGFPLGPALRRSDLIVAALRHLPVFTEAALHEIAEVNARYGDRVVWQVESPFALLGMVKADQLGAKWAAGPLLARQLAGVLTGIHEIGAQAVVHLCYGDYQHKALLSPRSLAPAVTLLKHTARRLRADGTPFPAVHIPCAFGAEPAPQDAAFYAPLRRLDPDWNVIAGVVSPDSADDSAHALQLFEQAAGRTAFGVATACGLGRCSVADAQRAAETTAALTAETTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBZ0</accession>
    <name>A0A231HBZ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator SutR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sutR_2</name>
        <name evidence="2" type="ORF">B7C42_01308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781690.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46342">
        <property type="protein sequence ID" value="OXR46342"/>
        <property type="gene ID" value="B7C42_01308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="21388" checksum="076EA994F05EAAFA" modified="2017-10-25" version="1">MDDGFEPVVAALGPRLRELRRRSGRTLTELSAGTAIPVSTLSRLESGQRKPGLGQLLALARAYRVPLDELVGAAASGDPRVYPQPFTRDGMTVIPLTRNPGGLQVFRQILPAGAGHREPAPRSHEGYHWLYVLDGRLRVVLGDQDLVLGTGEVAEFDTHLPHWFGNADARTVEFLSILGPRGERFHLRARYRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCH9</accession>
    <name>A0A231HCH9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative monoacyl phosphatidylinositol tetramannoside-binding protein LpqW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46555">
        <property type="protein sequence ID" value="OXR46555"/>
        <property type="gene ID" value="B7C42_01526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012827758" evidence="1">
        <location>
            <begin position="36"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="113"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="556" mass="60318" checksum="879DBE74CC451095" modified="2017-10-25" version="1">MRIRSTITRLAIPAVACGLLLSGCSGSTTGTGSSALGTTNDINPHDVADLRDGGSLRLAISEFPPNWNTLQIDGNNYDITAVERPMLPQAFTIDAAGGTHLNTDYFTNVELTGTDPQTVTYTINPKAVWTDGTPITWEDIASQAEALSGRNPEYLIANNMGFDRVAKVERGVDDRQAVLTFSKHFGEWQGQFSGNSMLYPKSVTSNPEAFNKSLVDGIKVTAGPFAVQSTDRTQGRITLGRNPKWWGAAPKLDTVNFSVLDSAALVPALQNDELDAIGIGSRGDLVTAQGVPNVSIRRAPALQWSHLTFNGAPGSILEDPKVRVAVSKAIDRQGIANAIQNGLVAEPKPLNNHIYLEGQKGYQDNALPYDPDAAARELDTLGWKLQGDVRVKDGRRLEIRDVMYNDPSWVQLAQIMQQNLAKIGVKLTIDTRPGQGLFTNVFQKGDFDLAQFSWVGDPFPLGSINQIWGYDPNNWQGNYGHIGSPELNDLIEKTVSELDPGKAIDLANQVDRQIFAEGHSLPLLQSPGIVAARSNLANYGARGLATLDWTKVGYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCJ7</accession>
    <name>A0A231HCJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775154.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46552">
        <property type="protein sequence ID" value="OXR46552"/>
        <property type="gene ID" value="B7C42_01522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="240" mass="26624" checksum="A3E1FE6E8A1CE442" modified="2017-10-25" version="1">MIVDWETYYTAGTKCRELAVSLRAADKPVHEAAEAQWSGMAGDAPGCMQWGQAYDEAARGTLQACASLANALTNYGAVLYAQGYNWGITNKSSPPPPQPDISQVGEYKVALPNSTHGTGIGFGDNGGAKEFFDDLFRKVVKSFGRIPNGDADKLQKAYNTWTAFADNSAISETLYRIMLISDLFIDMDDSSHRYEIQHRLNDLHTALKLSHWPPDAWLRRSTTITKQLRHWPQPAPTRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCU7</accession>
    <name>A0A231HCU7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">penP</name>
        <name evidence="8" type="ORF">B7C42_01729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46751">
        <property type="protein sequence ID" value="OXR46751"/>
        <property type="gene ID" value="B7C42_01729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00118">
        <property type="entry name" value="BLACTAMASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167062" description="Beta-lactamase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="7">
        <location>
            <begin position="87"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="34252" checksum="ED3969C33659D0DA" modified="2017-10-25" version="1">MTPPRFTRSAVLVAAAATLIPLSACGADRSAAPGSTSAGSTSAGSTPAGSTPGPTSTVPLADESLAEFRDLEARLHGRLGVYALDTGTGRAVEYRPDERFPYCSTFKALAAGALLSTLPPAELDRRVTYTRADLLPNSPVTEQHVDQGMTLREIMDAAVRFSDNTAGNLMFAELGGPQGLQQRLRAIGDSTTRMDRTETTLNEALPGDERDTSTPRALAADLRHYVLDPSVAADDRDVLTGLLRANTTGAALIRAGVPAGWQVGDKTGAGDYGTRNDIAVAWPPGRAPIVLTILSTRDRPDAEYDNAAIARAATIAIATLDGTAIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD53</accession>
    <name>A0A231HD53_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gpx2</name>
        <name evidence="6" type="ORF">B7C42_01822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46844">
        <property type="protein sequence ID" value="OXR46844"/>
        <property type="gene ID" value="B7C42_01822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="20424" checksum="6F9658045E1248BC" modified="2017-10-25" version="1">MPTLGTPSEDGPATEVALAPGEIPPIISTVTDIRDIPVQTLAGEPATLAELAGDKALLVVNVASKCGLTPQYTGLVALQQAYGSRGFSVVGVPCNQFMGQEPGTAEEIQQFCSTTYGVDFPLLAKVDVNGDDRHPLYRELVQTADAEGDAGDIQWNFEKFLIDRDGKVVGRFRPRTEPQDPSVVAAIESVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDD8</accession>
    <name>A0A231HDD8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46940">
        <property type="protein sequence ID" value="OXR46940"/>
        <property type="gene ID" value="B7C42_00056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059352" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="37912" checksum="DAABA7FE14840F97" modified="2017-10-25" version="1">MKKNRKVALVSAVVVVGLTAAGAVGYAASTDGSGSGGGSGFCADMSDTVGLYPGNPVTQMGFEVGRVESVHPEGDHVKVTFSLDAGRAYPADVKAVTRSKSLLADRSLELVGNYTSGPKLAAGRCVPTSRTFTPKSISQIAGSAADFIDAMSPNDHKKSFQQAVDGFDKAMHGNGELASQMMQHASEAMSSPNQFVSDVGSIIQNMAPMSDEALKKWATIQSILDQAPAITPAATDLIAAANKVAVGSVGWLVATLYMIQSDYGDMLWPQLNGPVSDAIHMAAGHSKDLAGLVNSIPSVASVLRQQSDSPGGLAVAYQPPTVQVNAPDAGQMCDVLNHMTAGSCINAGDHVQVSALRLLDLVVAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDM0</accession>
    <name>A0A231HDM0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46817">
        <property type="protein sequence ID" value="OXR46817"/>
        <property type="gene ID" value="B7C42_01795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="1">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="64" mass="7056" checksum="BBF859AB45B4AA72" modified="2017-10-25" version="1">MAGMQAHVGDHIRVHSNAVGMPERTGEIIEARGSDGAPPYVVRFEDGHESLVFPGPDWEVLHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE04</accession>
    <name>A0A231HE04_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46937">
        <property type="protein sequence ID" value="OXR46937"/>
        <property type="gene ID" value="B7C42_00053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="38447" checksum="3BD5A6859A896C66" modified="2017-10-25" version="1">MSKARNQDFLRGTDAEQTRVVTIAAVAMIAIAAVVVVGVVWVRPQLEKPSGMPLSVDVPFVAPGVGKGTKVILHGAEVGELTDLANHGDGVVRMSLLLNPGQVHGLTDDFDVDFRPENYFGITAVNLVTKAGGKQLASGQVLNRMPTGDFTMSTMLQKGSIAIDGTLTDSMIQSLNKVIRYTDGLTPMIQTGIVFADRVAKAQQAIPSELFGRADDILQVLPAFSQQAIDMLYNIYNNDYNKSGPGGSFGANEAAFSDIDKGLGLAATDLFGSAGKLLASHERELTPDVQLVQALVDALPHMMDGGAMPGKLSTLVDRYNRAFSNGPEGSKTLNMRVVLDDLPGMAAPLAATGLPQVPGQGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEB8</accession>
    <name>A0A231HEB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone protein ClpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpB_1</name>
        <name evidence="2" type="ORF">B7C42_00356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47234">
        <property type="protein sequence ID" value="OXR47234"/>
        <property type="gene ID" value="B7C42_00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="41"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="32679" checksum="82D9E0DDDB7FB2D0" modified="2017-10-25" version="1">MQTTVHEPIFASVDDVIDRLATTGYLADKATATSVFLADRLGKPLLIEGPAGVGKTELSRAVAQVADAELVRLQCYEGIDEARALYEWNHAKQILRIQSATSGGSDSGNAWADTKADVFSEEFLLQRPLLTAIRRTDPTVLLIDEADKADVEIEGLMLEVLSDFAVTVPELGTITATRRPFVVLTSNATRELSEALKRRCLYLHIDFPDEELERRILASRVPELKPAVAAQLVRVVHVLRGMQLKKLPSVAESIDWARTLLALGLKDLDDKTVRATLGVVLKHQSDHQRALAELKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEN8</accession>
    <name>A0A231HEN8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hpaIIM</name>
        <name evidence="10" type="ORF">B7C42_00546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234850">
        <property type="entry name" value="M.Nce30759ORF546P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47423">
        <property type="protein sequence ID" value="OXR47423"/>
        <property type="gene ID" value="B7C42_00546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="441" mass="48229" checksum="2E6EFEF8911F3C62" modified="2017-10-25" version="1">MSSLESGALFDLVEPDTPSAAPMRSGAGSKRRSGGSKRARGTRKTTDLRSAGLVTAERDFTSIEICAGAGGQAVGLHQAGFRHLALIEIDEYAVGTLRLNIEKHELWAWERDNCDIISADVKEFDPVNGLDKGSKILKERGLDLLAGGVPCPPFSHAGKQLGERDERDLFPRMLELVGILNPRAVLIENVRGLMDPKFSTYRAWIKSQIADLGYNLGAWEILEASNFGVPQLRPRAILVAFRDDVIRDIDYTMPEKTCDDPVSIAEILEPSMRERFDNVNAEHSERARQAFERWRDTARNRASELKGKGGGVAPTLVGGSKKHGGADLGPSRARAAWKQLGISGIGVANDIETCLNKGTEERDLFRPDGPMLTVRQAAIVQGFPDEWEFSGGKTAQYRQVGNAFPPPVAKAVGESIIKVLKEADERNRNNEAVECLTANVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEW8</accession>
    <name>A0A231HEW8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47429">
        <property type="protein sequence ID" value="OXR47429"/>
        <property type="gene ID" value="B7C42_00552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017685">
        <property type="entry name" value="ArgP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03298">
        <property type="entry name" value="argP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="32528" checksum="28E4ABBA6C46B1A7" modified="2017-10-25" version="1">MAELPVDQVRTLLAVVDEGTFDAAAAAMHLTPSAVSQRIKALEQRTGRVLLLRTKPVRPTESGQAVVRFARQLAALQEAAQRELGIAGDSGSTTLSIAVNADSLATWFLPALSRVPQDPPVCFDLHREDESHTATLLREGTVMAAVTSLAEPVTGCTARLLGLARYLPVASPEFVERHFASGPLEQSLPDAPVIVFDRRDELQDRYVRTVTSGRAGASRLRHYVPTSEGFRDTIVAGLGWGLVPETHADPLLRTGALRNFAPRQWVDVPLYWQQWKLDVPALALVAQTIGVAAADYLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF62</accession>
    <name>A0A231HF62_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47621">
        <property type="protein sequence ID" value="OXR47621"/>
        <property type="gene ID" value="B7C42_00746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="449" mass="50348" checksum="2C6DEC9FA0EE8858" modified="2017-10-25" version="1">MSVMVAQAETPRRELESETAVGWTPLTRVAFRFTFLYFGLFCLIYPQIVFAFTGWFGRWLDADAVLWQPRLLRPVLEWVGRTVFGVHPVLSPNGSGDQTILWVLVFCVLVVAVAGTLIWTLLDRRRADYRRLAGWFLLLLRLCVAGQMLNYGFAKVIPTQMPEPMLSTLLEPYGNLTPMGVLWNQVGASPTYEILLGAAELLAGILLFVPRTATVGAMLTLVSMAQVFVLNMTFDVPVKILSGHLMLMSMVLLAPQARRLLDVLVLDRPVGRSTAPYPFRTRGARWFAALAQIGIAIWVAVALTHVSLQLWHEGPGRTKPPLYGIWQVDEFRRDGQPVAPLLTDPDRWQRAVFDVDGVMQYQRMDGTFVPVQVRVDTGARHLDLHAVPGAEQQSVTSGGFAYEQQGPDRLRFIGDLDGHPVTVTFRRQDPDAFPQRSRGFHWIQDAPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF98</accession>
    <name>A0A231HF98_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proS</name>
        <name evidence="10" type="ORF">B7C42_00755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47630">
        <property type="protein sequence ID" value="OXR47630"/>
        <property type="gene ID" value="B7C42_00755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="35"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="585" mass="63469" checksum="DCA6A2B73ECEEB24" modified="2017-10-25" version="1">MITRLSHLFLRTLRDDPADAEVPSHKLLVRAGYVRRIAPGVYSWLPLGLKVLRKVEDVVRQEMDAIGGQEISLPALLPREPYETTNRWTEYGDSLFRLQDRKGADMLLGPTHEELFALTVKGEYNSYKDLPVTLYQIQTKYRDEERPRAGILRGREFVMKDSYSFDLDEDGLKASYAAHRQAYQRIFARLGVEYVIVAATSGAMGGSASEEFLASSPIGEDTYVTCRESGYAANVEAVVTPAPPEIPIEGQPAAVVHDTPGTPTIASLVDWANDAGIAEQFGRPVTAADTLKNVMVKLRHPDGKSEIVGIGVPGDREVDAKRLGASLEPAEVELLTDEDFAANPFLVKGYIGPKALLDNGVRYLVDPRVVTGTSWITGADASGKHVVGLVAGRDFTPDGTIEAAEVRDGDPSPDGRGVLHSARGIEIAHIFQLGYKYTDAFEVDVLGENGKPVRLVQGSYGVGVSRMVAVIAEQMHDEKGLRWPAEVAPFDVHVVIANKDEAARAGAEEVVAGLDARGLEVLFDDRTASPGVKFKDAELLGMPWVLVIGRGWADGKVELRNRFSGESEDIAAAAAVDTVLAKIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFU0</accession>
    <name>A0A231HFU0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4,5-DOPA dioxygenase extradiol</fullName>
            <ecNumber evidence="6">1.13.11.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ygiD</name>
        <name evidence="6" type="ORF">B7C42_00867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.29" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47742">
        <property type="protein sequence ID" value="OXR47742"/>
        <property type="gene ID" value="B7C42_00867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050297">
        <property type="term" value="F:stizolobate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="33"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="30770" checksum="5B32F38188087B96" modified="2017-10-25" version="1">MSPEQTSPEQMPAVFLGHGNPMNALDRNRYTEAWAAVGRAAPRPRAILVISAHWYTNATAVTAMPRPRTIHDFYGFPDELFAVDYPAPGLPELAEQVADVARPQWVGCDTDSWGLDHGTWSVLVHAFPDASIPVVQLSLNAFEPLDYHLELGRKLAPLRSDGVLIVGSGNIVHNLRAVDFAQPDAGYDWAVRFDEAAREVLTRAPTEAAALDAHPDFAAAVPTPDHYLPLLYIAGLADTEPLVPIVDGHCAGSISMAAYQLGGICPPQSAGSGAPGLPEGVPALDSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG78</accession>
    <name>A0A231HG78_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">recA</name>
        <name evidence="12" type="ORF">B7C42_00820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025351561.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47695">
        <property type="protein sequence ID" value="OXR47695"/>
        <property type="gene ID" value="B7C42_00820"/>
    </dbReference>
    <dbReference type="GeneID" id="66720494"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="36982" checksum="CA7A407BEE2C4CBD" modified="2017-10-25" version="1">MAPQAYDRDKALELALAQVEKSFGKGAIMRLGEEAHQPISVIPTGSIALDVALGIGGLPRGRVVEIYGPESSGKTTVALHAIANAQANGGLAAFIDAEHALDPEYARKLGVDTDALLVSQPDTGEQALEIADMLVRSGALDIIVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKMTSALNNSGTTAIFINQLREKIGVMFGSPETTTGGKALKFYASVRLDVRRIETLKDGSDAVGNRTRVKVVKNKVSPPFKQAEFDILYGAGISKEGSIIDMGVDQGFIRKSGSWYTYEGDQLGQGKENARKFLLENTDVRDEIEKKIKEKLGIGADVTADAGAEAPVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGD1</accession>
    <name>A0A231HGD1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782862.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47777">
        <property type="protein sequence ID" value="OXR47777"/>
        <property type="gene ID" value="B7C42_00902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="28142" checksum="6C5007AA33C2F16C" modified="2017-10-25" version="1">MVSHSAAEALPEWEAFARAVQARRPDAGTWCEGWTVRDVLIHNTGNAAELARVLSAHAAGSPVPTRGFEEREAPYRAMPDAELWAAFVDRCEQLVETAEVIDTLSPLEAIGWTGRTVAPDFFLEHMRQEMVLHRWDMTGDDATAIDMLMQPWITRHSVRDVGPPLLARGSRDIDFGPEGRIEGRLRAPGTDDVLVVAEPDGNSIDLAPPQGPATVESDPAVRALFLWGRRPADPTRWHSTAGPEELGRLRALLGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSY2</accession>
    <name>A0A231GSY2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000078">
        <property type="protein sequence ID" value="OXR39727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043496.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000078.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39727">
        <property type="protein sequence ID" value="OXR39727"/>
        <property type="gene ID" value="B7C42_08206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="21249" checksum="AC6CF0C2463DE761" modified="2017-10-25" version="1">MSHDQPYRYATTEADFTGLLGAITRALEDQSPWQRCTLSALTPGQAAERIGRDLFAEQARRFAHEVMTTGHGFIPLTYPVREPSDISPTGLWWLSFVDDTKSRSPAEQVPGAGGFLGVCIVQADHFMAAITISHRLGCNPGGQVQGYPTDAPPHPAWMNRLLSAADIDHIDAIEAELDTAQTAELLGRGLWEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT58</accession>
    <name>A0A231GT58_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782210.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39813">
        <property type="protein sequence ID" value="OXR39813"/>
        <property type="gene ID" value="B7C42_08101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="9566" checksum="FE0B6080E1411811" modified="2017-10-25" version="1">MATDRTPDSRADALLEQLRTASAELEETTRRLTERRNRIIVQLCEMQPLLSRKAIADAADLSENMVYTVFRKDKERRGTAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTD9</accession>
    <name>A0A231GTD9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000057">
        <property type="protein sequence ID" value="OXR39852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782468.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39852">
        <property type="protein sequence ID" value="OXR39852"/>
        <property type="gene ID" value="B7C42_08076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="537" mass="57621" checksum="C1256EAB947E94FF" modified="2017-10-25" version="1">MTAELDGVLQEMARARGAILALDGTQVTATIGGRSASLLLPADAEALTALSDLPSAFPSRAARGDVREKTLYNIVQDMVGISEGARLKDGTLRDELPGVIRADPASRRVLAAVMGRQYWFRPRSSSPVTFLSPFHADLPGAYDYMGRYKSFRGSLLLFLSFDGSGFDLSLAAEVLEFLSSEGGLNPLDRELLHAARAVAEQSGQRRVPDPQRLVELDGQLRPDAQVRARLARGAFDQPALDLIRRDLRTVMTLELPRHDKVAALVLAVSLHVALYYYRIAFRIGEGLQRAARALDGGGAPAAPDFSGAALFRVGSGGDRPVRESDPCARSWWQLDEQHLLALPATMIAANLLHAATTAVLGDRAPAIPDPSACAAALVTDGTSLALGELLCAAVAARVAEIAGDLPAATDPGAGGYALRAAVLETFRGRDTALKQRGRDVVNTMVGGFGGTLKRNRGRVRFFELDEQVLFLLVKLVLDGAGVEQMPLRSEFLPALRQYGLAPQNADEKELLADALERLGLLVRYSDAGEATYVRHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTG6</accession>
    <name>A0A231GTG6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39913">
        <property type="protein sequence ID" value="OXR39913"/>
        <property type="gene ID" value="B7C42_08018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="110" mass="12095" checksum="7DC33636DF9F375A" modified="2017-10-25" version="1">MVFTVRAMPHSTLATLLILAVYVLTAARLTRIVVVDKIGEPIRKAITNRFGAGSLITYLAFCPWCLGWWVTAVLAWPTAAVAGLPWWFGFGLWPAGSYLVGLLARWDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTL2</accession>
    <name>A0A231GTL2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043524.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39821">
        <property type="protein sequence ID" value="OXR39821"/>
        <property type="gene ID" value="B7C42_08109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17835" checksum="2BC9F70BD9C7922A" modified="2017-10-25" version="1">MTVVPLHQPRWDPDEHLIDAAIAGRVRGTDLPTTDRAWLVAHLTHRGHTTDTIAAWLHCSRRTVQMSRTEPVAVLTTRLLAAQAAVDKALSQARASRITPAAIDRLISENQRLRDSRGELIDQLAKARQLADIPCPPSVIVVHPARTRRRPPVAVPTLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTW3</accession>
    <name>A0A231GTW3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40032">
        <property type="protein sequence ID" value="OXR40032"/>
        <property type="gene ID" value="B7C42_07877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="32385" checksum="A0C6B4B936EF9406" modified="2017-10-25" version="1">MTTPVTRGGSRQTRKPAAPAYPDFVTFAEQWLFPFITVRLAEANREHTWTWCSQWWRHRAVSVRIAHLHRAFEAMRADKNAAGLSTFILHHLDPHLRVILDAANGPLHRCTRTKHVALPSLSCEPVPAGWFKRSVSPDAKSGDTKPYRFGHYADFVEQWLLPVTAVRIAANHRDDQNTWCRRWWDHRSVAVRFAALHVVFEAARVAEDRSAMSTLFVSHIDPHFRYILDAANGPLHRCTPDHHTPETGLPTADVPTNWFATLDNGMPVEELGFGPDFRHRKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU42</accession>
    <name>A0A231GU42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin reductase</fullName>
            <ecNumber evidence="3">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcD_9</name>
        <name evidence="3" type="ORF">B7C42_07790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042680.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40126">
        <property type="protein sequence ID" value="OXR40126"/>
        <property type="gene ID" value="B7C42_07790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="336"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="426" mass="45378" checksum="FBBD255AF3A6A734" modified="2017-10-25" version="1">MTESQNGTDVQAPPHGVVVVGAAHAGVQLADRLRAGGFTGELTLISDEPHLPYQRPPLSKAWLKGEATGDSVLLREPDYYRDQKIELIVGARVTHLSRTPVGVEVRFIRDGENSIREFDRLVLATGARPRRLPLPGADHPDVLVLRDLDDARSLAARVPAGPVVVVGGGFVGLEVAATARALGAEVTVIEAGERLLARAVGADTAAALLAAHRTMATDVVLGALPVSIEHRDNRIHAVRLDDGREIPAATVLVGIGAEARTELAEQLGLDCDGGILVDRHCLASDRWTLAIGDCTTHVSESGARYRLESVDNAVEQANAAAAVLLGEPCPQRPAPWFWSDQGDQKLQIAGLIGGHTSMLVRTDPQRPHRRVALYFTDDALVAAECLNSPADFVALRSALSRGHRPGPKDLADTAVPLKKLLAPMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUB7</accession>
    <name>A0A231GUB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pectin degradation repressor protein KdgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdgR_6</name>
        <name evidence="5" type="ORF">B7C42_07799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778644.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40135">
        <property type="protein sequence ID" value="OXR40135"/>
        <property type="gene ID" value="B7C42_07799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="76"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="27721" checksum="84D566AEFFC5F182" modified="2017-10-25" version="1">MTVTQEIHAAEANTPSNILDRLTLVLDAFDGHESLGLTEIVSRTGLPRSSAHRMLDRLVRLRWLQRQGRSYSLGIRLVELGSLAVHQDRVHAAAREHLHHLYRATGMVVHLAVLDGADVVYLDKIGGRLAAQVPTRIGGRLPAARTALGKALLAYDSHDEPGGRLVRQLGYAVERNGAPTGFGCIAAPIGEVGEAKTAVSICGPLNKMSFDSRMTTPVQLTAAAIVRSLNAGRFVTPTLQRKNILRSLPTAPSVLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUJ6</accession>
    <name>A0A231GUJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40300">
        <property type="protein sequence ID" value="OXR40300"/>
        <property type="gene ID" value="B7C42_07638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18918" checksum="795C4B673A4C67C0" modified="2017-10-25" version="1">MNDPQANRSKRGRDAGKLAGQLRHSREVMDRRRAVERRREQNVSDAVREYWSAWQAISTIEQRRDRRVRALRDKIGHLEQAAATEIAVHHDRQAAAVARMNEQGCNTDDIAELLEISLKGARQLLAAGRAEREPGVQTTHRQSEQRLNEPQRSAESAEQSPKPASGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUP6</accession>
    <name>A0A231GUP6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40265">
        <property type="protein sequence ID" value="OXR40265"/>
        <property type="gene ID" value="B7C42_07690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="932"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="797"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="932"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="989" mass="109116" checksum="FAD7245DDB6642DE" modified="2017-10-25" version="1">MIPKISRGQKLGGLLVYLFGPGDANEHKDRHIVVGSPTLMRTEWLRNFDGPADDRLSRDAALAIAREIEIPRRLYGTQARMRAKPVAVGARGRGVDVVEPAGKGEKGEMRDAPVWHCILALEPGEDLDDARFGQLAEDFMERMGFTGTADGKRAQARWVAVRHGKSGATGDGQEHIHIAASLIREDGSRVNTFDYGPGKPKGDRNRAQQVANELEHAYGLRVLGSRERGRGISGDSRAEIERAARLGAPESERERLRRIVRAAATGTDTEAEFVKSLRESGISIKPRYAQGDTSEVTGYSVRFRRDGGEVGPWLGGGKLAGDLTLTALREQQWNDSATAREEALAVWRNDSARRDRRVDRAVDDPQMWRQAATEIGQWREAMAQVPYEDRAQWAWMAGQAAGVFASWSEVLEGDQPGVFAAAHKELMRSAQVPAASQRYRPRNPGAAGLGGIARVLLDETFRDDSPLSRMRPHRSEDVLADVAAIIIVALLILLLIAIAIAAEIARAHRARGELDIAVAIEQATRYGMEPVRADWEAVLAERRYRFDRDAADVFAAAAGRRSEKALDALLTQAEQAATVDGRDTDSVAALGAERLAELTAAAEELVPGVADAEAWPVLRARLAAAEVDGRDAIAELTAAVELRELGSADDIAAVLIWRLDQLDTITKVESKATAEKAETSTGDTPPTIGGRGRDALAAAKAPRTPPAEQPQPSVRRKYYTEMTEDEREMARMRSVVDAGFARHDLAPETWNDARLTWELKHRRAEVKLLADEIEARRREGGPHTRAAIADNAVFAARAEKILAAQKAEQKAKELEREKAKLEQEKARLQQQLDETSKFKPVARKRFQDEIDTIDKHLDEVVTPAAEQARESADAAAEATGRHEYEWSSDLHAAQPRQQEIRLNAATATDERALNDDDNYLFRLQRNVSRIEREHARREAMTPEQREAADRAPRVAKRRSTSRETGTSLPGMPPTLGHQQDRGRDYGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUP8</accession>
    <name>A0A231GUP8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40298">
        <property type="protein sequence ID" value="OXR40298"/>
        <property type="gene ID" value="B7C42_07636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="44072" checksum="43B6D545EDCB74F6" modified="2017-10-25" version="1">MTDPILGPTCAVCDGAAAGTELCIANSAVCDSCWQQLPRCAYCRTPSLRLTRTADEAELCAHCLTGWARCVSCQELTGPQLRTDTDDPVCARCASVLFAACFNCGRFTADSRYISGGHRACPTCASRLRACPECGTLVQPGHRCDGCTSRGKVWNYTYRPDPHFHGTGPLYLGLELEIIVPEHRFDTCATLATDHLAGLGYLKRDSSIRPCGFELVSHPMSYRYAIESFPWPLLDRLHRLGCEADASVGLHVHASRAGFDNPAHVYRWLKLLYRNEETVTRLARRRTHYAQFDSAARARARDTAKGPQHALGLERYQAINPLPRNTLELRVFASSLNVQQVQAALAFTAASIDYTRGLRIADIRAGAWDWARFATWVTTRPDYQPLAQEMEHLQCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUQ8</accession>
    <name>A0A231GUQ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid-associated protein Lsr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lsr2_8</name>
        <name evidence="3" type="ORF">B7C42_07646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40308">
        <property type="protein sequence ID" value="OXR40308"/>
        <property type="gene ID" value="B7C42_07646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12465" checksum="2388537A40E8754A" modified="2017-10-25" version="1">MAKKVIVELIDDFDGKSKAEETVSFSLDGVEYEIDLSTKNARKLRGVFEQWTGSARKVRRVSRNRAKTAPRTAADKQQTGAIREWAKNNGYNVSSRGRIQADIIEAYNKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUY4</accession>
    <name>A0A231GUY4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40291">
        <property type="protein sequence ID" value="OXR40291"/>
        <property type="gene ID" value="B7C42_07629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027595">
        <property type="entry name" value="CHP04338"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04338">
        <property type="entry name" value="HEXXH_Rv0185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="18549" checksum="674123A390966FFB" modified="2017-10-25" version="1">MTARPRDGQRRKVYDAEHRLRALFDLADRTPGRSIEVFGSQICVPVERRLGTVESVTEYLAAVMALPSIRARYPRAAAPVRVRARRGSRYAHYESATATIAVPLREHAVRELLVLHELAHHLQPRPAAGHGPEFCRVFCDVLDTVVGAEAGWLMRTLLHDTGAHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV31</accession>
    <name>A0A231GV31_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetracycline resistance protein, class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tetA</name>
        <name evidence="8" type="ORF">B7C42_07425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40487">
        <property type="protein sequence ID" value="OXR40487"/>
        <property type="gene ID" value="B7C42_07425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="14"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="41248" checksum="0217AF24198088AE" modified="2017-10-25" version="1">MNDSHGAGSRLPAETWVLIGAAFLIALGFGLVAPALPQFARSFGVGVAAASAIVSSFALMRLLFAPVSGRLIQRFGERALYLTGLLIVALSTGACALAQTYWQLIVLRSLGGIGSTMFTVSSLGLVIRLSPPGERGRVSGLWSTSFLIGSLAGPLLGGALGGLGLRAPFAIYAVALLAASAVVFWKLRGSHLAEPVGAEPMPVVSFGRALDDPVYRAVLWSNFANGAAVFGVRMALVPLLVVEVFGESPGVAGVALTVFAAGNAAVLFASGRLSDQWGRRPFLIAGTLVCATGTIALGLAPTVVWLLGASFVAGLGSGMYTPAQQAAVADVIGPRARGGPVLAGYQMAADLGTVVGPIAIGWLAQRVSFGFALAVTGALLVVAAAGWTVVREPLQRHLVTAFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV57</accession>
    <name>A0A231GV57_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40504">
        <property type="protein sequence ID" value="OXR40504"/>
        <property type="gene ID" value="B7C42_07443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15355" checksum="E4A4135DD81399E6" modified="2017-10-25" version="1">MTQLDEFGRTPLHYAARDANLPQVERLLDTEEVNLADHQGWTPLHFAANAGAPDVVARLLAAGADIDALTEKGMPAIYWAAVAKRGNPVETIRVLRAHGADPTRETIETYFGLKSPLHFIAETRNKPEIRAEFADLINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVQ4</accession>
    <name>A0A231GVQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylic acid transporter DauA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dauA_2</name>
        <name evidence="7" type="ORF">B7C42_07226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40668">
        <property type="protein sequence ID" value="OXR40668"/>
        <property type="gene ID" value="B7C42_07226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="434"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="539" mass="54914" checksum="0AB75882A07D8F12" modified="2017-10-25" version="1">MNIAALLPRWCDWRPAVRAPGPDLLSGLIVALVALPLALGFGISSGLGAAAGLTTAVVAGIVAAIFGGSRFQVSGPTGAMTVVLVPIVHQHGGGGVLAVGLMAGIMLVALAVAGAGRAVRYMPAPVIEGFTAGIAVVIALQQLPNALGIAHAHGDKVWQSAYDAVRQYISHPHLAPVVIALAVAAVMLVGGRFVPKLPFALPAVAGATVVVAVFDIHTAAIGALPSGLSAPTLGFLDWGSLGSLVAPALAVAALGALESLLSATAADAMAVGTRHDPDRELFGQGLANIAAPLFGGVPATGAIARTAVNVRSGGRTRLAALTHAVVLAAIIYAAAPLVADIPVAALAGVLLATTVRMVEAASLTAIARASRGDALIMAATFLVTVALDLVTAVGVGVAIAVVLALRSVAKEARLHQVPLDETDHLTEEHGLLHDGIVAYRIDGPLFFAAAHRFLLELTEVTDVHVVVLRMSHVTTLDTTGALVLKDAVTKLQHRHITVLMSGLREDHRRRLAMLGALPAGGETQIFEQTPDALAYARAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWJ1</accession>
    <name>A0A231GWJ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025351469.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40966">
        <property type="protein sequence ID" value="OXR40966"/>
        <property type="gene ID" value="B7C42_06932"/>
    </dbReference>
    <dbReference type="GeneID" id="66723692"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025242">
        <property type="entry name" value="DUF4193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13834">
        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="10900" checksum="6C053652D9A320E3" modified="2017-10-25" version="1">MATDYDAPRRSESDEVSEDSLEELKARRNEAASAVVDIDESDTAESFELPGADLSEEVLSVRVIPKQADEFTCSSCFLVHHRSRLASEAGGQMICMDCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWX7</accession>
    <name>A0A231GWX7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-containing monooxygenase EthA</fullName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ethA_2</name>
        <name evidence="1" type="ORF">B7C42_06852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41082">
        <property type="protein sequence ID" value="OXR41082"/>
        <property type="gene ID" value="B7C42_06852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="53133" checksum="23B7B25B247F3591" modified="2017-10-25" version="1">MNGPAEIDVVIVGAGISGIAAAAELQRKCPGKSFAVLEMRESLGGTWDLFTYPGIRSDSDMFTLGYGFKPWTEREAIASGGAIKNYLRETADQFGITEKIRFGTRLVSASWSSADDTWTLGLRDADGDTQLRCRFLHLATGYYSYRGGFNPELPGEDSFEGRVVHPQEWPEDLDYRDRKVAVIGSGATAITLVPSLAGETAKVTMVQRSPTYVAIAPAVDPEAERLWEEMGPEDAFSRIRLRNLHAQQETYQYARQHPQEFKKAIFDAIDDVVGVEVRKAHFTPTYEPWDQRVCLVPGADLFQAIRDGSADVVTGHIDRLTPTGVAMRDGTHVDADIIVKATGLNLVMGGEATFDVDGEIVDFGRCWTYKGLALSGVPNLTYAFGFVNSSWTLRIEAVDDFLCRVLAHMDEVGARRVTPTLAPGDDAMPRLPYTAGVTSGYMQRAAPRMPAQGDHEPWVNPQNYAETMRLLESVDDDVLRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWX9</accession>
    <name>A0A231GWX9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenolphthiocerol synthesis polyketide synthase type I Pks15/1</fullName>
            <ecNumber evidence="8">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_06725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41130">
        <property type="protein sequence ID" value="OXR41130"/>
        <property type="gene ID" value="B7C42_06725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1684"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3423"/>
            <end position="3498"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="5116"/>
            <end position="5191"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="6805"/>
            <end position="6880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="6184"/>
            <end position="6206"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1719"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="3458"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="5151"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="6840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="7165" mass="747300" checksum="D52D5670CE575544" modified="2017-10-25" version="1">[encoded data, 7165 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX41</accession>
    <name>A0A231GX41_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41190">
        <property type="protein sequence ID" value="OXR41190"/>
        <property type="gene ID" value="B7C42_06786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="649" mass="65388" checksum="0A9F0A8E9CBBE4B1" modified="2017-10-25" version="1">MSGSMEVDPAVLLDLALQHDRVAEDTLEWAKPPTDWLREFPNTYGHIADPVLGALQDYYQARQNAGIALAKEHRDTAAKLRAAAAAFERSDEDGAANIRRYDDTNGSGAAPYQQSPSLPGSGTQAPTGPQVGAPGSGPADAGAHTPGDTGADTPMGVAPGTAPGTSSATPDSTGTAPGTAPVGAGAGTGTGPSAAGGPAGPGGGPSGPPSGPLGTTPPSGVVPPGGPAGPPSGFGPDERGQGPNGTTAAGDLPPVPVPTPFAAAVAKAKDAEAEPAYVVGDAVDNDLLIARTLLGAVLAAVDSSVLGLHWAVAVLRGPAGAGVFITSNEGRGWFPAGLYLPREVSSPWIWDEVLADGSGDPASPWEGVSDPARVLAEFGLAWGRKAGAELTALVSSGSIDHGLRQRFPSVAMQDLVGPSYDVDLRVFTPDTADRLALAGSGEALEHVAAVPDAQIRARCEELATEAHRLVAGSAPGGPDAAQSRGIRDRILSALGSGRPIPASWWEELRDADDLLTAAMLPHRVDVGRVDVGELRVDDEAAALRALVFERRCNELVLLLAGEASRQQLRDAVYAHEQIVKHPRFVAAPAAVSTGVGERVSRPAASSGSVAAPVAPVAPPTVSVPPTAGGPPPGAVSAPDTSAPDVTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXE4</accession>
    <name>A0A231GXE4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG_29</name>
        <name evidence="2" type="ORF">B7C42_06633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41235">
        <property type="protein sequence ID" value="OXR41235"/>
        <property type="gene ID" value="B7C42_06633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082145" evidence="1">
        <location>
            <begin position="29"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="26590" checksum="A33FB042425A3C15" modified="2017-10-25" version="1">MGIMDRFRLDGRVAVVTGASSGLGVAFAAALAQAGADIVLAARRLEKMEQTAELVRAAGRQALCVPTDVADPEQAQRLIDAAVERFGTVDVLINNAGIGTAYPATRETPEQFRQVIDINLSGAYWVAQACGRVMRPGSSIVNISSILGLTTAGLPQAAYSASKAGLIGLTRDLAQQWGTRKGIRVNAIAPGFFTSEMTDQYRDGYLDSMAPRLVLGRIGDPEELAATVIWLASDAAGYVTGQTIAVDGGFTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY81</accession>
    <name>A0A231GY81_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41548">
        <property type="protein sequence ID" value="OXR41548"/>
        <property type="gene ID" value="B7C42_06441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030981">
        <property type="entry name" value="SDR_subfam_2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04504">
        <property type="entry name" value="SDR_subfam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="27075" checksum="CAD20D82BBCDFA71" modified="2017-10-25" version="1">MAPASVAIVTGAARGIGAATVHRLAAAGWRVVAVDICRDDPALGYPLGTRDQLAAVAAAHAGTVVDVEADVRDIESLGRAVELAMDRFGRLDAAVAAAAVMTGGHPLWETTHADWAPMFDIGVHGTANLARVAVPAMLARPEPRTGRFIALASAAAHHGMWHLSGYNAAKHAVVGLIKGLAHDLRGTGITATAVSPGSTRTALLTETARLYHLDTVDDFASHQLLDRILEPEEVAATIAWLCTPESAAVTGSVVHADGGFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYM5</accession>
    <name>A0A231GYM5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41723">
        <property type="protein sequence ID" value="OXR41723"/>
        <property type="gene ID" value="B7C42_06065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="518" mass="57309" checksum="3298BB75750647A4" modified="2017-10-25" version="1">MLLRDGRFSAVRLGPARVLGTFRAGLLGGRIPLRDRTLRTTRRFVRVASRRRRTGFALGDRMGSCRCRGAGAVRDRDVFSGRARPGFRVRTVFAWGGGFFVNLAHRAWRRARGELRRRRGFAQRVDRSGRGRLRGGDRFLGRWPLARSSCLGMRARPCRGSVGGRRTHLLPGLAAIGSDRCTPFAAWAWFRGRGLRCDLGARPAALTCGLRGLRGRAPRLPRVRPRPFRFRRHLDRPPRRPGFPVVPCRERVGWCEGPAAVDGPYGGAAAGMHAPGECAVEQRREHLVVVLRPTGHHRGRTQTRYRTGGAVHQAHGQATAADPGKYHRRELSGEHAARRSTHPRQGRDFDRLQIDAGRIRSVRSDDVGGAIAGGDLQRLHPRVHAHGQRGRLAQHGGELQRARRGQPSSRLRRTGLDRPFQARPHGRYLAASLDEHGVHGGRGGGRAGRSRRRGAAHHTEDAPRQVDTEREHHAQPLLRVVGGRLRLVGQGGGVVTELGRAFSVRSQCVAQPVGQLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYM6</accession>
    <name>A0A231GYM6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41724">
        <property type="protein sequence ID" value="OXR41724"/>
        <property type="gene ID" value="B7C42_06066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="530" mass="55471" checksum="42021ED60382EE54" modified="2017-10-25" version="1">MSGELRLDLAGLRERGARLSELADRVGQTYAGLRDCLDQARGSWGDDYMGRQFAEQFTPHADQMLANVRAMEKGLHSTASGIVGVADEFDAQDAGNAARLADAAEDRTPGGGSSPTLRPDNAAGPTAPVDTGAQVPYDPAASAPARNSAVADGPARRAGQPPAGGSQSPNGSPARTVPQDGAQSRSPWNQDRPTSDPSGQDGRHPAGDSDRRPSSVSAPPPSSSAPPPADRRNAPRATDASSGGRAAPPKRGDTPWGGQPPRPSGTPGRSETPGKTGSPGRPESNPRHGSPPRSGRPSRDKARADDRRRSREQRASDPMIGWLARTVAERHGVEVTGFDTPGLQLPPVRDFLAAVDRVLTEYPMIRLNSVAVAELGGERGTVRWSREPGDEGSTSSMTLDLRTAREPAADPTTESGGEPARSEIYPATLHELGRALDDAGGGAARKQAQRVLIGEYLRRDPQPDRTLAEVVSGYRDWRAGLAGKATAPGEFDVGHALGIAFAEVVQHGAEAGIQARLLHAVLVAAASRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYP8</accession>
    <name>A0A231GYP8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41705">
        <property type="protein sequence ID" value="OXR41705"/>
        <property type="gene ID" value="B7C42_06047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="8973" checksum="8DD1190A841026EB" modified="2017-10-25" version="1">MSKVPPSDAARYLTLPSTSNRRITDPAVMVPMAAVNPIAVGVAPWLAMSVPPARPAREYAAIRLTLRNDDARPSRSSGTFRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYR1</accession>
    <name>A0A231GYR1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsR1_2</name>
        <name evidence="4" type="synonym">rpsR</name>
        <name evidence="6" type="ORF">B7C42_06089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505473.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41747">
        <property type="protein sequence ID" value="OXR41747"/>
        <property type="gene ID" value="B7C42_06089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="9539" checksum="928648A4F465D355" modified="2017-10-25" version="1">MAVKRAPSKRIRAEQARRPKKNPLIAAGVEIVDYKDVNLLRTFISDRGKIRSRRVTGLTPQQQRQVAVAVKNAREMALLPFTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ25</accession>
    <name>A0A231GZ25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41863">
        <property type="protein sequence ID" value="OXR41863"/>
        <property type="gene ID" value="B7C42_06205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="54" mass="6086" checksum="F617D70B10165978" modified="2017-10-25" version="1">MVTPTRLYRWLTATTYAAVVVAAWLLLYWPWLRQLPLPQPDGAQICRGAEAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ39</accession>
    <name>A0A231GZ39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41858">
        <property type="protein sequence ID" value="OXR41858"/>
        <property type="gene ID" value="B7C42_06200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="8685" checksum="1DDDA6D790838921" modified="2017-10-25" version="1">MADSQVPWGLEALGVVTKAAWHTKPSWYLHVTEDRMIPPAAQASMAQRIGATIVETPGSHAIHVSQPGVVADLITKAAATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ69</accession>
    <name>A0A231GZ69_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular esterase EstB</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">estB_7</name>
        <name evidence="2" type="ORF">B7C42_05872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41888">
        <property type="protein sequence ID" value="OXR41888"/>
        <property type="gene ID" value="B7C42_05872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218065" evidence="1">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="32603" checksum="47DFB1471DDFC9CB" modified="2017-10-25" version="1">MIDRLIRRRHRRLAAVGALVAGALAVAATSAAGTPDYGPPQTNWEAALAYSVTNPEALPTGMSDPGCRPAAAHPRPVILINGAFLDSYANWAMYSPRLRAEGYCVFGLNYGGPAAGPFHQMGDLRESAREIGAFVDRVRAATGSDRVDLVGYSEGGLVPFYYLNMLGGAPRVDTMISLDSPVRGMSGYGVLAEISALPGGPQALGSVLPAARDGAAGSAFIDEISAGGQTRPEVRYVTITSRADLVVAPEEARLPSAPNVSEVVVQDNCPQDQVFHGSVIYDDITLRLVLNALDPANAVAPVCHPVLPVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZC0</accession>
    <name>A0A231GZC0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41966">
        <property type="protein sequence ID" value="OXR41966"/>
        <property type="gene ID" value="B7C42_05950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004062">
        <property type="term" value="F:aryl sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010262">
        <property type="entry name" value="Arylsulfotransferase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05935">
        <property type="entry name" value="Arylsulfotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="443" mass="48327" checksum="677BA0443EF0DE5B" modified="2017-10-25" version="1">MAFVRLTGVTYHDPEAAHDSYILFTGADGVTRLIDLTGDVHREWPFAGVPPRILDPALNNGRLGDVGVQLEPGDDPRGGIYANRTVGQLDWSGEKVWEWGREAPGGAARQNHDWELLPNGNRLLLVTIPRIVPGLGSDPIGDQGLYEVDPDGAIVWEWRAGDHLHELGFSEAGWDALRATVLRDPDDPWGYLEINSAKSLGPNHWHRADPHTVFHPDNILISCRKANVVALIDKTTKAVVWRLGPYFDAEPGAQHQRINAHKVPRPLDQISGQHNPHLIADGLPGAGNILIFDNQGGAGYPPAPLGIYAGSRVLEVDPSTRQIVWQYTAEDSGLPSWTFFSSFVSNAQRLPNGNTLITEGMQGRIFQVTPQGQVVWEYVSPYEGLGVAGEPEVREPRVPGVDRLSATPMVYRAQAVPFDWVPIGAPRSAPVAVDLRGTVPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZE8</accession>
    <name>A0A231GZE8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <ecNumber evidence="1">4.1.3.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menB_3</name>
        <name evidence="1" type="ORF">B7C42_05875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41891">
        <property type="protein sequence ID" value="OXR41891"/>
        <property type="gene ID" value="B7C42_05875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="27569" checksum="A88A8B1DCAA7DC3F" modified="2017-10-25" version="1">MAADELRQDRPASGVLRLTIDRPRAHNALTIALQRRLDTALTEAATDESIRVVIVTGAGGRAFCAGYDLKELDAMTPQALAESMAEREDMLWRYLHYPKPTVAAVDGLAYGAGTMYAACSDLRVGGPRTSMAVSAARYGGVNLSWLLDSLIGGARTRDLLMTARAVPGDEAFDMGLLTRYTPDVAGEAVRTAEQIAAQPPDGLRHIKQLLLDGAGQGLRERYDRENSVTRATLGQRSITDMFSAFFANGPAAAPGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZT2</accession>
    <name>A0A231GZT2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane mycolic acid synthase 1</fullName>
            <ecNumber evidence="3">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cmaA1_2</name>
        <name evidence="3" type="ORF">B7C42_05708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42109">
        <property type="protein sequence ID" value="OXR42109"/>
        <property type="gene ID" value="B7C42_05708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="33980" checksum="4408A74AB6ECF57E" modified="2017-10-25" version="1">MTGYAPADRRIPSRDQLPDEFFAQFLDRTRTYSCAYWTHPDDTLEQAQSAKIDLALAKCDLRSGMTLLDVGCGWGSTMLRAMDTYGVNAIGLTPHRNQHRYVRDRLVDRLVRGCPYGGVRRQGWHQFDRPVDRIVCIGVLEHMPPQRYPDFFDFAYRVMPDDGVLLVQTVVAHDPYAAGGHRESGPTADTDFAFLRGAVFPASRLPRSTGHHPRGITEYAQDAGFTLTRVQELGSHYTTTLDSWAISLHEHRDRAIELAGQHTYDAYSSYLTECAATFRRGRLDVMQFTCTKSGARQPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZU7</accession>
    <name>A0A231GZU7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddn_5</name>
        <name evidence="3" type="ORF">B7C42_05728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42129">
        <property type="protein sequence ID" value="OXR42129"/>
        <property type="gene ID" value="B7C42_05728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="55" mass="6357" checksum="93E149CF7D855E28" modified="2017-10-25" version="1">MIGGRRRKIHARTANPEERARLWPQITEAYGGYANYQTRTTREIPVVICELEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZW7</accession>
    <name>A0A231GZW7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_05739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783706.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42140">
        <property type="protein sequence ID" value="OXR42140"/>
        <property type="gene ID" value="B7C42_05739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="664" mass="71603" checksum="7FA7F9BD3A79ABBF" modified="2017-10-25" version="1">MVSPIDVAKRVVLGRPFRSDRLGETLLPKRLALPIFASDPLSSVAYATQEILLILTLGGLSYLYLTPWVAGGVVVLLAVVALSYRQVVRAYPSGGGSYEVVAENLGAIPGLVVAAALLVDYVMTVAVSVAAGVDNIISAAPALNPHRVLIDIGFIVALTAMNLRGVRESGRAFAVPTYGFVAGVMVMISIGLIETLIGHAPVAESAHYQIHAAHAGLGTAAVAFLALRAFSSGCTALTGAEAISNGVPAFRKPKSLNAARTMTAMGVLAIAMFTGVTALAMITHTRVAENTCDLIGFPGDCRTDAQKTVIAQIAGAVFGDTSPGFYYLMVTTALILILAANTAYNGFPLLTSILAQHRYLPRQLHTRGDRLAYSNGIILLAAVAAGLIYAFDGQTTRLIQLYIVGVFTSFTLCQTGMVRHWNRELVGVTAPAQRQRIHRARAINAFGACFTGVVLVVVMITKFGHGAYLVVIAMPLLVLMMYSIHTHYTSVRAELDIDPDEETTLPGRVHAIVLVSDWHKATQRAVQFARATRPDTLTAITVNVDDSDTRALTQSWESHDVTIPLKVVESPYREITRPVVEYIKRVRGSRPRDVVSVYIPEYVVGHWWENLLHNQSSLRLKARLLFEPGVMVTSVPYQLRSSRNRKPPTVTPSPGQVRRGIVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZW8</accession>
    <name>A0A231GZW8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dodecin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42092">
        <property type="protein sequence ID" value="OXR42092"/>
        <property type="gene ID" value="B7C42_05691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13793" checksum="539F51643A40D5AB" modified="2017-10-25" version="1">MLQIGEFFTAVADPVYACWSRRTRGNYPGLDYAVHGCPGGIVELSTSAEPEGIDMTDHTYRVIEIVGTSPDGVDAAIRSGLSRAAQTTHNLDWFEVQSVRGYLEDGAVAYYQVTMKVGFRIEDVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H024</accession>
    <name>A0A231H024_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADPH oxidoreductase</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_05812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779705.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42213">
        <property type="protein sequence ID" value="OXR42213"/>
        <property type="gene ID" value="B7C42_05812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="50"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="289"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="370" mass="40353" checksum="F2E85717AD041B1F" modified="2017-10-25" version="1">MDLLKWSKRPAADISAKKPRVNVVRGLVARATTPLLPDDYLRLVNPLWTARELRGKVVDVVKETAESATVVIRPGWGFPTNYTPGQYVGIGLQIGGRWHWRSYSLTSIGASGDKTISITVKANPDGFLSTHLVDGVEPGTVIRLAAPKGDFHLPEPVPEKLLFVTAGSGITPVIAMLRALEAHGQSPDICHIHSAPTRDDVIFADEMQTRADNSDGYDLTLQLTREMGNFDAARLDEWVPDWRERHCWACGPPALLDEMESHYEAGGLRHRLHTERFTIARTDHGGEGGTVYFAASGKKAEIDGATTLLEAGEELGIGMPFGCRMGICQTCVVPLAGGYVRDLRTGAERREGERIQTCISSVSGECTLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0E4</accession>
    <name>A0A231H0E4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_05519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42320">
        <property type="protein sequence ID" value="OXR42320"/>
        <property type="gene ID" value="B7C42_05519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="28283" checksum="C091E5F9C5D5B1DF" modified="2017-10-25" version="1">MTGDRAVWLYAVAASRDDAIAPDGPAGVAGELVRTVVSGDLTAVVGSVPLDVFGEEPLRRNFEDLDWLEATARAHDAVVSAVVRRGPAVPLRLATVFRDDDRVRELLDERRADFVAALELVSGRTEWGVRAYGDRAALTAAVAEAKADAGTMTPGAAYLARRRAQLSAQETVERDAAERAAQVHARLLRRAAAGRCQPLTDPAVSGRRDWMVLNGTYLVDDDRTEDFTATVTALGAEFPGIRLELTGPWPPYSFAGVQREQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0K5</accession>
    <name>A0A231H0K5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42376">
        <property type="protein sequence ID" value="OXR42376"/>
        <property type="gene ID" value="B7C42_05575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="26532" checksum="DD70CDEF8E6DF553" modified="2017-10-25" version="1">MNPDLPIWKALEHMLTPDQLADQAGSWERRTAVLAAIVHGWDVDEAVRFLAGPTAEPRGAGVRHIVQTDLCPAGDVGESVRRYIAAAAICAALAAAGCSSTTEGTPTTTADKAADLWDPCTGIPDNALRAANVDPASKESGVGGIQQSGWKICGWRGPEYSITAYSTARSVDEFEHKPGNVDFTDVTIAGRSGRQFRVEGASKQLDCNVVFPVQQGVVQLQVLGRASLDNPPEPCGVLARIGESIVPSFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0L9</accession>
    <name>A0A231H0L9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_05557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42358">
        <property type="protein sequence ID" value="OXR42358"/>
        <property type="gene ID" value="B7C42_05557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="419" mass="45631" checksum="6D2D8F55A612579E" modified="2017-10-25" version="1">MPGAHRIGRLVWLVPVLLVALSVFWLLRPSWPLQPIKREFIDLQVYRLGVQAMWDGADMYGSLPKTTLGISLPFIYPPFAAVALGPFALLPWNAAAISFFVVSTLALAITLYLVARRVWGSGGTEVVLWASACAIPLGMLLEPVHSTLDFGQVNLLLMVLVAADCLPKRTRWPRGMLVGIAAAIKLTPAAFVLYFLVRRDYRSAITAAITGAVASGIAFAVMPHESVKYWFGGMGNVSGLSGSAFRTNQSIQGVLSRFQVPEPAFTALWALLSLALLVLVVAAMRRAVADPALALAFNAVFTLLVSPISWSHHWVWIAPGLLAAVGVATRLPRRTAIIWYAIIIATAVVFTIGPQNWEPGDNNRELAWTPWQHLVGDTYVWLSVLLVALYVVTGPRPTTQEPLLPASLRSLRTKVPTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0M6</accession>
    <name>A0A231H0M6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate pyrophosphohydrolase</fullName>
            <ecNumber evidence="3">3.6.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mazG</name>
        <name evidence="3" type="ORF">B7C42_05592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.8" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42392">
        <property type="protein sequence ID" value="OXR42392"/>
        <property type="gene ID" value="B7C42_05592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047693">
        <property type="term" value="F:ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="27824" checksum="D3733BC1A698C88D" modified="2017-10-25" version="1">MSEDRGERPSGGSDDAAADSARVAHGLTEAVEVMDRLWNFGGWEVTQTHDSLRPYLLEETYELLDAIQHGDAETIKEELGDLLLQVLFHSRIAEAAGEFTVDDVAAALVAKLVHRSPHLSDPEVDAGTDVAAKVAAQERAWEERKLTEKARRSCLDGIAMAQPALALAEKIRSRSAKAGLPGDLVPDDLRVVHLGEPDSAEERLRKATLDFAARIRAAEDAAERTRGGRGPLSPDEWRAHWETFADSPGGPQRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H101</accession>
    <name>A0A231H101_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_05302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42526">
        <property type="protein sequence ID" value="OXR42526"/>
        <property type="gene ID" value="B7C42_05302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="144"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="28051" checksum="BA70920BD53EB871" modified="2017-10-25" version="1">MTGYDVVVQTDQVFEMYKPVLTGDRLISDVELSAVRRIGGRDLLTITNTFIDRTGDVVQLMHTTVLGLTGADVDAEISDTIERVVMSGLDTPPRTTAAAAAANGPSPAAAKSGTTARLSPVSRTRTPQTALRFGDITVGDELPARSVTLTRGDLVNYAGVSGDVNPIHWHAEIAALAGLPDVIAHGMLTMGLGAGFVTGWLGDPGAMTRYSVRLSNYTVIEAASAGTVEFTGRIKSVDPETRTAVVVIVAKSAGRKVFGLATADVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H136</accession>
    <name>A0A231H136_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Phosphoribulokinase</fullName>
            <ecNumber evidence="3 5">2.7.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cfxP</name>
        <name evidence="7" type="ORF">B7C42_05287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phosphoribulokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.19" evidence="3 5"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036501267.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42511">
        <property type="protein sequence ID" value="OXR42511"/>
        <property type="gene ID" value="B7C42_05287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008974">
        <property type="term" value="F:phosphoribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006082">
        <property type="entry name" value="PRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00478">
        <property type="entry name" value="PHRIBLKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00567">
        <property type="entry name" value="PHOSPHORIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="6">
        <location>
            <begin position="7"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="32611" checksum="390743EE1CB629B7" modified="2017-10-25" version="1">MSRKHPVVAITGSSGAGTTSVTRTFQEIFRREGINAAIVEGDSFHRYDRGGMQVAMAEAEADLNLHFSHFGPEANLLTELESLFRDYGQSGVGLVRKYLHDETEAKPYGLEPGTFTPWEELAPGSDLLFYEGLHGAAVTGTVDVARYADLLVGVVPIVNLEWIQKVIRDKTERGYSSEAVIDTILRRMPDYVKYICPQFSRTYVNFQRVPTVDTSNPFTARSIPTADESFVVIRFADPKVIDFPYLLSMLHDSFMSRPNCIVVPGGKMDLAMQLIFTPLILRLMDKRPGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H143</accession>
    <name>A0A231H143_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative NAD(P)H nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42570">
        <property type="protein sequence ID" value="OXR42570"/>
        <property type="gene ID" value="B7C42_05347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="350" mass="38073" checksum="20335DD021F00A08" modified="2017-10-25" version="1">MRRPITAGHRPGMSVRRSKGRTGIMTFADPFTAVFADAVEMAVRAPSVHNTQPWRWSLREETIHLHADESRQLTVTDPAQRALLLSCGAALHHMRVALAMLGWSAQVGYLPDDSDPDHLAAITVRPRTPSGRDIDLAAAIAHRQSDRRRYSTRPVPQAFVREVSADARAYGAAARQIPPELRPELADAARTATLRHAADPAYLHELAAWSGRHGTTDGVPAANTPAPRPDDEIVKRRFESPELADPATEPEAAEWLVVCTTGDDRLARLRAGEAVSALLLSATTLGLSSSLQSEPLAMPDLRAEMRRHVLAECAYPQTMVRLGWLPSGAAPLPHTPRRPVTEVTAAAVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H186</accession>
    <name>A0A231H186_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">pyrD</name>
        <name evidence="13" type="ORF">B7C42_05396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778192.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42618">
        <property type="protein sequence ID" value="OXR42618"/>
        <property type="gene ID" value="B7C42_05396"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="49"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="322"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR42618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="38136" checksum="55B7219FD670804C" modified="2017-10-25" version="1">MYSLFLRLLFLVPPERIHHLVFTVIRLTTAFPPTRWLARRLTAAGDPILSTTVFGIDFPAPLGLAAGFDKDAAGVNAWGALGFGFAEIGTVTAQAQPGNPAPRLFRLPADHALINRMGFNNHGAAAAAGRLAARRSGGVPIGANIGKTKVVEPEHAAEDYALSARLLGPLADFVVVNVSSPNTPGLRDLQAVESLRPLLRAVLDSVAAGAEPKPVLVKIAPDLSDEDIDAVADLAVELGLAGIVATNTTIRRDGLATAAEKVSAMGAGGLSGPPVADRSLEVLRRLYARVGDRLVLISVGGIENADQAYERILAGASLLQGYTGFIYGGPFWTRTVHRGIAARLRADGYRSLTEAVGAAHTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H277</accession>
    <name>A0A231H277_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42949">
        <property type="protein sequence ID" value="OXR42949"/>
        <property type="gene ID" value="B7C42_04835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="29448" checksum="F36148B1E8CE61A8" modified="2017-10-25" version="1">MTVSMHSTGKASFDDIYDRPDPSAYCRRMAELDYCIPELAKPAFLELFADYEAHTGTAPTVLDLGCSYGVNAALLRFGTTVADLAEHYGDADTATCIARDRARLAADDRLPEIRFIGMDASAPALDYAAATGLLHETVHADLEAGDPTEAQRKIIGSADLVISTGCVGYVTGRTLTRVARAHGTRLPWMAHFVLRMYAFEPIARELAALGYRTERRPGTFRQRRFASAAEQQQVLNTLTANGIDPTGYESDGWLHAELYISTPTPEDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2F6</accession>
    <name>A0A231H2F6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43007">
        <property type="protein sequence ID" value="OXR43007"/>
        <property type="gene ID" value="B7C42_04893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="36412" checksum="F0815E8A6EA0E8C4" modified="2017-10-25" version="1">MSLPGMDVAALERFLREQGVDVRGELRVELISGGRSNLTFVAADEVSRWVVRRPPVAGLTPSAHDMAREFTVTHALRESAVPVAKTVAFDADGATLGAPMTVVEFVDGTVIRDQDDLAALTDTQIDTAVDELVRVLAELHAVDPVAVGLEKFGRPDGFVTRQVNLWASQWERVKTRELPDVASLHAALAEAVPDRSAASIVHGDFRIDNTILDARDPGQVRAVVDWELSTLGDPLTDVALMCVYRAPIFDLVLGSPAAWTSHRMPGADDLAQAYAAASGRDLGDWGFYLALANFKLGVIGEGITHRALRGSDAGSAAERAAEATPEFMAAGLRALKGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H314</accession>
    <name>A0A231H314_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43263">
        <property type="protein sequence ID" value="OXR43263"/>
        <property type="gene ID" value="B7C42_04685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="14795" checksum="DAC62DD4124F5E69" modified="2017-10-25" version="1">MTTPTRNLDWLLDDLVAHIPGVRHAVVLSTDGLLLSRSTVMPVEDAEHFAAMAATLHGLARSAGHRFTGGTVRQTVIELDHAVMFATAAGPNACLALLTDETANMGMVAYEINQTVHRVGTFLSAAPRRGFGRMGDPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H375</accession>
    <name>A0A231H375_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crt_12</name>
        <name evidence="2" type="ORF">B7C42_04756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43333">
        <property type="protein sequence ID" value="OXR43333"/>
        <property type="gene ID" value="B7C42_04756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="27413" checksum="78819891E2B4E1CA" modified="2017-10-25" version="1">MGEKNEGVEAEPVLVTRQGHVAILTLNRPDRRNAINRAMRKSIKRELWKADADDDVRVVVITGAETAFSAGVDLPEALTGPPPRTEGTTPTQVLRAIGKPVIAAVNGPCYTGGFEFAVNCSFIIASEQAVFADTHASIGLLNGWGGSAMLPRIVGLPAAIQIILSGDPIDSATALRIGLANEVVPHEKLMERTLEIAESIAASHPVAVQRMLRLLKEGAGASVAHALGLEAEASASWRPDGKDIGDRFGKRSMKSKADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3J8</accession>
    <name>A0A231H3J8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nitrate reductase</fullName>
            <ecNumber evidence="12">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">narB_3</name>
        <name evidence="12" type="ORF">B7C42_04295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="12"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43428">
        <property type="protein sequence ID" value="OXR43428"/>
        <property type="gene ID" value="B7C42_04295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
        <property type="entry name" value="MopB_CT_Nitrate-R-NapA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041957">
        <property type="entry name" value="CT_Nitrate-R-NapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="784"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR43428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="808" mass="89364" checksum="CEC4AB6D88D420B7" modified="2017-10-25" version="1">MHIRSGAQTAGANEHDRIAHPWGTRTPYGPGERWPERVDMFLAEGVREDMVERWVPTASVLHSNGDAMDIAVQEGRIVGVRGRAGDRVNRGRLGPKDLFGWQASNSADRLRAPLVRRRGKLVETDWDTAMSMVAERTRDLLGERGPGSIGFYTTGQLFLEEYYALTVLARGGIGTDHLDGNTRLCTATAGEALKESFGSDGQPGSYADVDHADVIALYGHNVAETQTVLWSRMLDRLRGPNPPALVCVDPRTTQVARAASIHLAPRPGTNVMVMNALLHELIRNEWIDRDYIDAHTVGFDELRTQVAGCTPERAAEICDVPAADLRAAARVIGTGERVLSTVLQGFYQSHQATAAAVQVNNIHLIRGMLGRPGCGVLQMNGQPTAQNTRECGANGDLPGFRNWANDSHVEELARLWNVDPERIPHFSAPTHLMQILRFVEDGSIRFLYVNGTNPAVSLPELARVRALLSQRRLFLVVQDIFLSETARLADVVLPAATWGEKTGTFTNADRTVHLSEKAVEPPGAARPDLDIFLDYARRLDLRDADGAPLLPWRTPEEVFEQWKRCSAGRLCDYSAMTYAKLRALGGIQWPCTEEHPEGTERLYADAKFRAAPQDCETYGRDLITGAPLEPTEYRALNPEGRAIIKAAEFLPRHESPSEDYPYALITGRTLYHFHTRTKTGRAPQLQAAAPEVWVEMAAEDARREGWDDGDLVRVRTPRGRVTARLRTGDIRPGVVFLPFHYGYWDTAAGDRPAGKDGTAANELTPTEWDPVSKQPLFKSGAAALERVRPGRRSERTTTAAVELERSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3U0</accession>
    <name>A0A231H3U0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">mdh</name>
        <name evidence="13" type="ORF">B7C42_04382</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779249.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43514">
        <property type="protein sequence ID" value="OXR43514"/>
        <property type="gene ID" value="B7C42_04382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="160"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR43514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="34494" checksum="8446658991318F07" modified="2017-10-25" version="1">MSNAARTPVTVTVTGAAGQIAYGLLFRIASGAMLGPQTPVRLRLLEIPAAVGAVEGVAMELEDGAFPLLESIDISDDPWAGFDGASIAVLVGARPRTAGMERSDLLAANGPIFTDQGAAINASAADDVKVLVVGNPANTNAFIAMSNAPDVPAARFTALTRLDHNRAIAQLAARSGAPGSSITRMTVWGNHSATQYPDISHTLIGGQPADRVIDDPAWVRETFIPTVQQRGTAIIAARGASSAASAASAAIDHVHDWVLGTAAGDWVSMAVPSDGSYGVPEGLISSFPVTCAGGEYSIVPDLEIGEFSRARIDLSVAELAAEREAVIDLGFAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3X6</accession>
    <name>A0A231H3X6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit</fullName>
            <ecNumber evidence="3">1.18.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bedA</name>
        <name evidence="3" type="ORF">B7C42_04329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43462">
        <property type="protein sequence ID" value="OXR43462"/>
        <property type="gene ID" value="B7C42_04329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008860">
        <property type="term" value="F:ferredoxin-NAD+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="317"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="410" mass="42667" checksum="AC148EAD7E49A9A6" modified="2017-10-25" version="1">MTGRIVIVGAGIAGATAARTLRTEGYTGEIVLLGAEDRLPYRRPMVSKELLAGTANERRLLLESAQSWRELEVELRLGTTVEGIDVDRDRIHLGTGETLGYDALVLATGARARELPGPESGAYTLRTAADVDALRAAVMTGGSLLVVGGGLVGCEAAATARGLGAAVTIVHAADAPLDRVAARVIGEYCRNLHADNGVDIHDAIVLDRIDGGDGDVTATAVDGRRWTAAAVLVAIGAEPDTGLARQAGLAVGDGILVDESHTTSAPNIFAAGDAAAVYDPEFGVHRRTEQWNSAQAHGVAVANSVLGQPVPAEEVTWGWTTQYGVTMQFAGRPQPEDEVVVRTTGTPGRFLALSLRAGRLVAAAAVACPAELRTARTLIAAHTTHPVETWSDATIPLQELAVATELSSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H429</accession>
    <name>A0A231H429_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-exo-hydroxycamphor dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.327</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">camD</name>
        <name evidence="5" type="ORF">B7C42_04527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.327" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43659">
        <property type="protein sequence ID" value="OXR43659"/>
        <property type="gene ID" value="B7C42_04527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018452">
        <property type="term" value="F:5-exo-hydroxycamphor dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="190"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="373" mass="39247" checksum="23E196481DD2D3EE" modified="2017-10-25" version="1">MGTTRTSRIAVLTEGGRPIDDAHIEVPSAGPGQILARTLLGGVCGTDVHLRRGDFDLPYPVVLGHEGTGIVEQLGPGVTHDAAGVALAPGDPIYWCPIPPCHHCYYCTVEKDFSSCPNAAWFHRADQPGWGSYSDLVTLPAGMAAYRIPDGTSPEAVIALGCALPAVLQGFDRAGFAGVIDSVVIQGAGPIGLSAVLVAQQRGARTIVVIDQHENRLATARKLGATATLSLSTDADDRRARVHDLCGPHGPQLVVEAAGVLSAFGEGVDLAGHNSCYLLIGLWSGHGATAIDPTVVVHKNLRIVGSCYAQPEHYYKAMHLAATLERKVPLAEIITHRFDVTEVNEALDTVERGDAVKAVIQPVGNTAAVRVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H479</accession>
    <name>A0A231H479_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781208.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43753">
        <property type="protein sequence ID" value="OXR43753"/>
        <property type="gene ID" value="B7C42_03988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019639">
        <property type="entry name" value="DUF2505"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10698">
        <property type="entry name" value="DUF2505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17127" checksum="029536EEAA225677" modified="2017-10-25" version="1">MATPLAYTAHYAHPAAAVRAALADEQYWKDRVEEVGGPGARLDSFSADGDRLRVEMVQTIPASELPPAITSVRPGDLIIPRTENYEGLSGVFEAHVEGAPAKVRGTVTLTGSGTASQAVVDGSVEVTIPLFGKKIEAVVAEKLLELLASETEFTNTWITNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4N8</accession>
    <name>A0A231H4N8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">hemC</name>
        <name evidence="9" type="ORF">B7C42_04023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781255.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43788">
        <property type="protein sequence ID" value="OXR43788"/>
        <property type="gene ID" value="B7C42_04023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="228"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="34583" checksum="9E307F3D8F6F351D" modified="2017-10-25" version="1">MTRRGTTDAPWRIGTRGSVLALTQAGTVRDALIATGQHAELVIVKTAGDQSSDPVEKIGVGVFTAALREELAAGTVDIAVHSYKDLPTAPDPRFTIAAIPPREDPRDVLVARDGLVLGELPAGSRVGTSAPRRAAQLRALGLGLEIVPLRGNIDTRLRKVAEGELDAVVVARAGLSRVDRLGSVTEALEPVQMLPAPAQGALAVECRSEESDLVSILSTLDDPGSRATVVAERALLAELEAGCTAPVGALAEVVESLDDEGRVVEELSLRGGAAAIDGSDVIRASAVGSLANAEQLGRDLARELLELGARDLLAGEVSAGASDFTNPSPMENKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4T1</accession>
    <name>A0A231H4T1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">drrB_7</name>
        <name evidence="10" type="ORF">B7C42_04063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781152.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43828">
        <property type="protein sequence ID" value="OXR43828"/>
        <property type="gene ID" value="B7C42_04063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="37"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="29693" checksum="AF285B09556423D6" modified="2017-10-25" version="1">MTTTLPAPATGRHAARAAIPVASNRISLRQTVANSLTMAYRGILKIKHNPEQLFDVTVQPILFTALFAYIFGGAIGGSVQAYLPVLIPGILVQTVVLTSVVTGTQLREDMDKGVFDRFKSLPIARVSALAGALIADMVRYGIATVLTIVVGLILGYRPEGGVVGVVVAGLVVVFCSFAVSWIWALVGVTGKSAASVQGISMMIMFPLTFMSGAFALVSTMPGWMQGINKANPVYYMVNSCRELMNGNIYSSNLAWCLIGSAVVIAIFAPLAIRAYMRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5I1</accession>
    <name>A0A231H5I1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4'-demethylrebeccamycin synthase</fullName>
            <ecNumber evidence="1">4.3.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rebG_2</name>
        <name evidence="1" type="ORF">B7C42_03588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.5" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44032">
        <property type="protein sequence ID" value="OXR44032"/>
        <property type="gene ID" value="B7C42_03588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="46378" checksum="E0232D407AF1C1C9" modified="2017-10-25" version="1">MTSVLLTATPVRSHVTPLLSVAEALIAAGDRVRFLTGTRFRDDVLATGAEFLPLPSEADYDDRDIDAAFPGRRGLSGPAGIRYDMIEIFLRPVPAQLRAVREAIAAEPTDAVLAESMFAAAAVLGGIPRSERPLLVNLGILPLALKHPDVAPFGLGIAPMRGPLGRLRNAVLTLGAEKGVFAPVQRFANEIARAETGRALPRFFLDWPAGADHIVQFTVPEFEYVRRGLPDTVHFVGPVARSRPSAIPVPEWWDDLAGRRVVHVTQGTVATGEWNLIAPTVRALAHDDVLVVVSTGGRPVGTLPNDLPANVRVAEFLPYDRLLPQTDVFVTNGGYGGVHYALEHGVPIVVAGRTEDKTEVSARVAWSGVGIDLRTDNPTPDKVGGAVRTALTDERYRLRAKEIGDSIRRSPGPEAVHGIIADAVRSAGRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5T5</accession>
    <name>A0A231H5T5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777398.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44122">
        <property type="protein sequence ID" value="OXR44122"/>
        <property type="gene ID" value="B7C42_03679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="14943" checksum="7D52792086A9DE13" modified="2017-10-25" version="1">MPLSEHEQRMLEQIESALYAEDPKFASTVRGGRLRSATGRRRLQAAALFVLGLVLLIAGIALPVKPGGFPIISLLGFIVMFGAGVLLLLGGSGMTKSGRGGGDASSGPGGAPGRAAKSKQRKAGGFSARMEDRFRRRFEQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5W4</accession>
    <name>A0A231H5W4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-glyceraldehyde 3-phosphate reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gpr_1</name>
        <name evidence="2" type="ORF">B7C42_03812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44251">
        <property type="protein sequence ID" value="OXR44251"/>
        <property type="gene ID" value="B7C42_03812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="35042" checksum="3998E379D58B21D9" modified="2017-10-25" version="1">MGESSSLRRVGNSGLAVSVVGLGTNNFGMKLDLEQSRAVLHAALDHGITLIDTADSYGESERRIGEILQGRRDDVVIATKFGNDVRRLGGDNGEDWGARGSRRYIRRAVEQSLRRLRTDWIDLYQLHRPDPATPIEETLSALDDLVHEGKIRYLGHSNFTGWQTADAEWTARTRNLERFISAQNEYSLLQRGIEADLVPALEHYGIGLLPYFPLASGLLTGKYKRGVPAPEGSRIQAWGRESALTDAAFDIVEQLEDFAAQRSITLLDVAIGGLAAQPAVSSVIAGATSPEQVEANVRAGQWQPTAEDLAEIDRITSVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5X5</accession>
    <name>A0A231H5X5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_12</name>
        <name evidence="3" type="ORF">B7C42_03850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44289">
        <property type="protein sequence ID" value="OXR44289"/>
        <property type="gene ID" value="B7C42_03850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="421"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="510" mass="55766" checksum="6BBCBC7EA74BE1D8" modified="2017-10-25" version="1">MYPGAHVDRFPDKPAVVLAESGAALTYRELEDNSVRLARHLYDAGLRKGDHVALLSGNTLEVYEVYWAALRSGLYITAVNRHLSADEISYIVNDCGARALIVSAELADVAERVIEQTPEVGIRLAFGGPVPGYDSYDKALAASSAEPLPDQPRGADMLYSSGTTGRAKGIKHPLPDRQVGDAPGDTYTAVFGPLYGFDTDTVYLSPAPLYHAAPLRFGGVVHALGGTVVVLERFDAEQALAAIERYRVTHSQWVPTMFVRMLKLDESVRARYDVSSMRVAVHAAAPCPVEVKQAMIDWWGPVLHEYYASTEGNGATFIDSEQWLRKPGSVGPAGLGAVRICDDDGRELPAGEIGTIYFEREEVPFDYHNDPEKTAKAIHPDHPTWTTTGDIGYIDADGFLFLTDRKAFMIISGGVNIYPQEIEDALALHPDVLDVAVIGVPDEEMGESVKAVVQPAPGAEPGPELAQRLRDFLRERIAHYKVPRSVDFADELPRTPTGKLVKGKLREQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H608</accession>
    <name>A0A231H608_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein LpqE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lpqE</name>
        <name evidence="3" type="ORF">B7C42_03232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44443">
        <property type="protein sequence ID" value="OXR44443"/>
        <property type="gene ID" value="B7C42_03232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011237342" evidence="2">
        <location>
            <begin position="33"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="23950" checksum="26AACDE601F0A649" modified="2017-10-25" version="1">MTALKATTASNVTKVSRRAIAVAALATGAALALSGCGAGQISQTAGQVPAVNGSAATVGNVALRDVRILLPQSEEYTNAKGGKSVVAFSAINEGSSKTDQLVSITTDLGQVKITPATPELAPGQTVVAASPEAAKAAQGGAENASPTTGAAQPTSPAATPTPEHSASPRQEGAGSPDQPADPNAHPILVEITGLSKDIVPGLTYGVTFNFKNAGTVQVQVPVDAGPDTPRHEGATVAEHGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H614</accession>
    <name>A0A231H614_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44344">
        <property type="protein sequence ID" value="OXR44344"/>
        <property type="gene ID" value="B7C42_03905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="26305" checksum="9AA249CCC48B2088" modified="2017-10-25" version="1">MAVQVEIWTDINCPFCYLGKRRFEQALAGFEHRDQVRVVHRSFELDPTLPAGHSGPVVAHIAEKYGISEAQAAANERGIAAQAQAAGLPYRTEGRDFGNSFDMHRLLHFALDRGRQDEVLDALYEGNFADERPVFGDRERLIELAARAGLDPVEVRATLDDPQAYADAVRADENTAAQLGARGVPFFVFDRTYGVSGAQPPEVFSQALERAWADHAPALQVLGDGDACGPDGCAVPAADDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H631</accession>
    <name>A0A231H631_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44463">
        <property type="protein sequence ID" value="OXR44463"/>
        <property type="gene ID" value="B7C42_03252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="230"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="32196" checksum="434E23809784785F" modified="2017-10-25" version="1">MAGVRTAIPRAIGLIALMACVVFALRGYLPGTGGPHAPSPPSAVTVALMPVLSLVSVVILLAGVLTSQHHAPLAMAEVDRDRKRQPFRLSRFGIVILIGTAVAAVLTAIVWAVYLLAGGREEAPAPRSNPPATAQPETTAPPTTEPFSGTPELSGHALLFVGICAAVLVAVAILGLGVVAFGARDGRGAPAVPSTPAPAEAPVSLAQVAEMGLAAMMASGKDARAAIIACYVAMESGLAQAREVAPLVSDTPSEVLARAFDRGVLHDASARELVTLFEEARFSPHSILEWQRMRAEQLLRIVLADLQGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6K4</accession>
    <name>A0A231H6K4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid-associated protein Lsr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lsr2_2</name>
        <name evidence="3" type="ORF">B7C42_03211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44422">
        <property type="protein sequence ID" value="OXR44422"/>
        <property type="gene ID" value="B7C42_03211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="13193" checksum="450982674F650062" modified="2017-10-25" version="1">MAKKVTVSLIDDVDGETIADETIEFAIDGVSYEIDLSAANAAKLRDGLDVWVANARRVSGRRRSKPVGATTGAPKGRVSMDREQSAAIREWARRKGHKVSARGRISADVVESYHKEVGRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6K9</accession>
    <name>A0A231H6K9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">tilS</name>
        <name evidence="10" type="ORF">B7C42_03186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44397">
        <property type="protein sequence ID" value="OXR44397"/>
        <property type="gene ID" value="B7C42_03186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="8">
        <location>
            <begin position="77"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="TilS" evidence="9">
        <location>
            <begin position="293"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="82"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="38475" checksum="FFC60839C7F9D03E" modified="2017-10-25" version="1">MNPADLPAEAPGTGPVSAAEIRSPDDAESPSAPGPVRAGTQEARAADRARLPETRAVLVMRHAVREWLARYAPAGVVAVALSGGADSLALTAAAVAEAAAVDALIVDHGLQEGSAAVAEEAGEVARRLGCRSVRVCRVSVTGPGGPEAAARQARYAALDELRDGLPVLVGHTLDDQAETVLLGLARGSGQRSIQGMAGYDEPWGRPLLGVRRAVTREMCRDLGLDPHEDPHNAAPEFARARLRTEVLPLLEEVLGGGVAPALARTAAQLREDGEALDAIADRLLIDARDGSSLSVETLATVPPAIRRRVIRAWLLGGGAKALTDKHLRAVESLITDWHGQGGVAVGGGMPGIRLVARRERGRLTLAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6S1</accession>
    <name>A0A231H6S1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775973.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44548">
        <property type="protein sequence ID" value="OXR44548"/>
        <property type="gene ID" value="B7C42_03337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="122"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="421" mass="44534" checksum="FADE2696F1F9BA70" modified="2017-10-25" version="1">MNAIRTITKVPKWVRVVAAALVVALAGWIVYGAVTNIGKTHITAYFPSTTGLYAGDDVRVLGVKVGRIDAIEPGRDKTKVTMTVDRGVDIPADAKAVTVSPNLVSARFVQLAPVYTGGPKMHDDGVIPIEHTAVPVEWDDIKAELTKLSKALGPIGEDQQGSFGRFVNTASDNLANGNAQALRDTLHELSSTLNTLSDGRTDLFGTVRNLQQFVDVLSKSNDQIVQFGGRLASVSSVLSGVSDDLGAGLDNLDSAVADVKRFLDERGGQLTESVQNLAQVTQILADKRPQLEQVLHSGPVALSNFYQIYKPAQGTLTGAVVLPNFRNPFAFLCGAVEALEDNGSQRTADLCKQQVAPVISSLMMNYPPLLVNPASGQQAFPSQLTFSPPSLADRVEYPAPGEAPAEVPSGLAGLAIPGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6T6</accession>
    <name>A0A231H6T6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposon Tn10 TetC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tetC_2</name>
        <name evidence="5" type="ORF">B7C42_03381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776023.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44591">
        <property type="protein sequence ID" value="OXR44591"/>
        <property type="gene ID" value="B7C42_03381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22194" checksum="D243419491F24D5F" modified="2017-10-25" version="1">MPRRSQEDRSRATRASLESVGRRLFAERGYSAVSAEEIVAAAGVTRGALHHHYGDKRGLFIAVLEQLEADNTEEVRRAIDTLPDPTDLPAAMATGLHTFLMISRRPETVRIAMSDGPAVLGWQGWREMEARHGLGLITNQLELAVESGLAPAVPVRTLAQLILAAITEAGMIVAHADDPDAAGAEAEQCILMMLGGLLTPPSTSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H790</accession>
    <name>A0A231H790_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44596">
        <property type="protein sequence ID" value="OXR44596"/>
        <property type="gene ID" value="B7C42_03386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="43"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="30495" checksum="69A8AC5B3DD2BFFF" modified="2017-10-25" version="1">MSAPAAPREIGAIGHVLAVCVLHAELEVPAKVSRVGRTAIDKRPVADRVAVRTLGLAGDHVCDTKHHGGVHQAVYAYADEDARQWGEQLGRTLAPGWFGENLRVSGLPVSDAVIGERWRVGEAVLEVSAPRVPCATFGHWSGEKQWVKRFTLQADTGAYLRVLTEGTIGAGDRVHVDHIPEHGITVRDLFTGHDPARLERLLTAEPTISDDVRMQIARHARRAGNGARATAPSEGFGIATASDAAPGRTTSKPAAAGAGTPHSVMPSGAAARPKAAGATACGDVERGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7D5</accession>
    <name>A0A231H7D5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl-phosphate mannosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.54" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44636">
        <property type="protein sequence ID" value="OXR44636"/>
        <property type="gene ID" value="B7C42_03430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047267">
        <property type="term" value="F:undecaprenyl-phosphate mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="26037" checksum="94A45855447E765A" modified="2017-10-25" version="1">MKVTVVVPTYNERENLPVAVERLTALPVADLHVLVVDDNSPDGTGEVADKLAAELPSVVDVLHRTEKDGLGRAYIAGITAALDQGADVVIQMDADLSHPAEVIPAMLEKLETSDAGVVLGSRYVAGGSTAAEWKWYRKALSAWANFYVNAILRLGVKDATAGFKAWKADTLRAIDVASIHSNGYSFQVEMNYRTIKQGISIAEVPIRFEERTKGASKMSLKVQLESALMPWKLLFGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7L4</accession>
    <name>A0A231H7L4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44747">
        <property type="protein sequence ID" value="OXR44747"/>
        <property type="gene ID" value="B7C42_02701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="9294" checksum="5C2B13C8576E6097" modified="2017-10-25" version="1">MSSTEPPAPAITPAQRRSTGESFGIDPARYDRTRPPYPQAMIDRIVESSPGSNYLNAGCGTGIEARQFRAGAGCRTRRPDGRLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7M9</accession>
    <name>A0A231H7M9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dhbF_5</name>
        <name evidence="10" type="ORF">B7C42_03520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44726">
        <property type="protein sequence ID" value="OXR44726"/>
        <property type="gene ID" value="B7C42_03520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="969"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2014"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="2348" mass="250492" checksum="C559BB55BD759DC6" modified="2017-10-25" version="1">MTCEDPTASPASASGLPPGAFELSPAQAGLWHAQQLLPSVPLCVAQVLEIDAELDVALLQRCALVAGHELASPFLTFLRHDGRIVQRVDHSLQRTIRIDDFSERRDPPAAVREWIDADLRAPIDLLVDEPGCSHLFRVGRHHYWWYSRAHHVGIDGIGAMILLRRTAELYSAACTGTEARPSGALALPDIVAGEYAYRRSARAERDRIYWQECLAGLRAVPSLSGRVAPPRAVPLAARGVLPPESEDALSAAAGRFDAQTPVLIVATVLAYLARMTGARDVVVSLPVAARTTAALRRSAGMVANIVLLRAHVDPDTTVADLVRQVRLAVTGALRHQHYRLEDVRRDLEPAFGGHGALGPVINLMLVDESLRFGGEPVGVKVLPVGVVEDVALNVCRFGAHAPLRIDLSGNPALYTDAALSEHHARLLRLLDAVVAAEPDTLVGALPLLTPSDEAHLHDRAREHVEASSVALLPDILADGAAHARAAAVEADGVRCGYAELDNLSSQWARELIAAGAGPETVVAVLVDRSLASVMAFRAVAETGATWMPIDPATPDERVARMLADARPVVGLTVGDYAGRRSGGLRWIVLDDPETCARVRARPAAPVRDSERTRPLHSTHPAYLIYTSGTTGSPKGVSITHRGLANLTRYVVAHYRVRPSSRVLLAHAPGFDAALLELLAAFGAGATMVVCPPDVIGGSALTRLLSDRRITHYLSTPAVLATMDPAALPELETVVTGAEACPRTIVAAWSERHRLINSYGPTETTVIATQTEPLGVDGPITIGTPAAGAEVVVLDRRLQRQPREASGELYVSGPGIARGYHRSPALTATHFVADPYGPAGSRMYRTGDLARRRLDGAFDYHGRGDSQISLRGIRVEPHEIESALADDPQVARAAVAIHPGPSGDVLVAYLIPAGAELAADSVLSRVRRALPQPLVPTTAIVLPELPRTANGKLDRAALPAPALSAARYRAPRTPTEEAVASTVAQLLGIARAGRDDDFFALGGHSLAATQLASRLSESTGAVLGVRDVFEHPTVAALARRIDEGSEGAALVQLTRRDPRPGRIPLAPAQRRLWIANQRDPDSAAYNMPFAVRLDGSLDTGALTDALRDVLERHEPLRTVFPADAQGPAQRVLPVDELQLELSPQPIAPEELGARLEALASAGFDASVEPCFRVTLLRLAPSAHVLVLVLHHLVADGWSMGPLARDLGAAYAARCAGDRPGWSPLPVSYADYALWHTDVLGDTSNPDSYGAEQIRGRQQRLAGLTPERVPASRPGAIRRTARGDHITVGVDPVSCQRLSRIAHAVGATDFMAYQAVTAVWLQRLSGGGDTVVATPTSGRGDRRLDALVGMFVNTILLRAQVNPCDSFRRVLSRVRDFDIAAFAQSDVPYEQVVAAIGASDMQPAQTMLIVETAVGEQPTLPGLQLTEVPLELSVARFDLDITLTQRRDSAGNLIGVDARFGYAADLFSRRTAEAYARMFATLVTTLAEDPDTELSRLAPAAPPVAPPDPSPPVRTLPELLAAGAHRNPDGLAIRDGDRALSYRALESRAARVARELIELGVGPEQIAAVAIPRSLESVLAWWAVTMTGAATLMIDPDQPRARIATVMSDARPVSGVTLARHAAALPHPARGWVVLDDPETGAHIAGRSSDVVTDAERTMPLHVDHPAYVTFTSGTTGRPKGVTITHRGLAALTAHLTDRYRVGADARIAHAHAPVFDASLLELFAGLGCGATVIVVPPGIVGGAELTRLLARERVTHYLSSPVVLSSLDAGQLTDLRTVVTGGEPVDTGVITRWAHPRRRLINSYGPTEATVVSTQTEPLTPGGPVSIGAPIPGVSALPLDRWLALRPPDVPGELYLAGPSLARGYHRDAAATAARFVANPYGPPGSRMYRTGDLVCRRRDGRLDYHGRVDNQINLRGHRIEPGEIESLLAAHPQVSRAAVAVYHQGLPDARLVAYLVPENGAVDSEAVLARVRESLPSHLVPAGACVVAALPTNQAGKLDRAALPAPPPASARRPACGDVEKLVVRTVTELLGVEDVAANDNLFALGLHSLTATELAGLLRARTATPITVRDIYTHSTPESLAALLDRDVAAPDAADPDAALRTVLPIRAAGTLPALWCIHSAIGLAWSFAGLTAHLDPETPIYGLQIPQLTDPAAEFDAIEQLADHYLTEIRAHQPHGPYSLLGWSVGGSIAHAIAVRLRAEGRSVALLAMLDSAVLTHEAFADDAPDAARIRRLLNKFAVHTESLDDRHRDVLCRTGVRTIEMARRYSPARFPGDLLYFGAAGRPDADLGVNSWRPFIGGTITTLRVPADHDEMTSAAALEFIGPQLRMHMPRHPHRVDGLDPEETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Q5</accession>
    <name>A0A231H7Q5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trpB_1</name>
        <name evidence="11" type="synonym">trpB</name>
        <name evidence="13" type="ORF">B7C42_02867</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44911">
        <property type="protein sequence ID" value="OXR44911"/>
        <property type="gene ID" value="B7C42_02867"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="88"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR44911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="45902" checksum="B6B9410B0280B255" modified="2017-10-25" version="1">MCASGSHTLSEPDGEKKARMRMVIGHRPPHATTRDGIRDPGRFGAFGGRYVPEGLMAALTDVENAHRAAWADPEYHRELDRLLRERIGRPTLLHAAPRLARALEVPGVRVFLKREDMTHTGAHKINNALGQALLAVRMGKTRIIAETGAGQHGVAVATVCAMLGLSCVIYMGADDMARQQSNVVRMRLLGADVRAVRSGDRRLKAAVTEAVRDWVAHTETTHFLFGTAAGPAPYPRMVRDHQSRIGIESRAQLLAATGRLPDHVIACVGGGSNAIGMFHAFTGDAQVRLTGVEAGGRGLHTGEHAATLSAGTPGEMDGSFSYVLQDHEGQIARTHSIAAGLDYPGVGPELSHLKDIGRLDHAVATDAVALRGLDTLCRTEGIITALESAHAVGYLLESAEQGAIAEDSLILLCLSGRGDKDLAIVADLLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8B7</accession>
    <name>A0A231H8B7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein NrdH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nrdH</name>
        <name evidence="5" type="ORF">B7C42_03007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Electron transport system for the ribonucleotide reductase system NrdEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780008.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45050">
        <property type="protein sequence ID" value="OXR45050"/>
        <property type="gene ID" value="B7C42_03007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011909">
        <property type="entry name" value="GlrX_NrdH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02194">
        <property type="entry name" value="GlrX_NrdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8409" checksum="A83FDECDF45FDA01" modified="2017-10-25" version="1">MSITVYTKPACVQCNATYRALDKAGVEYDVVDISENPEARDYVMALGYLQAPVVVAGDEHWSGFRPDRIKSLVTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8P3</accession>
    <name>A0A231H8P3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45324">
        <property type="protein sequence ID" value="OXR45324"/>
        <property type="gene ID" value="B7C42_02449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15586" checksum="BF8ED9D08824AB6A" modified="2017-10-25" version="1">MDPNDPDGAADQLTAWADDLEHKAERYRELRDRMASLSVTETSRQGIAVTVDGEGIPTDIRFADSVRGIDPAALSAELMRTLQRAQVRMRDQIAATVHETVGDDEAGANIIDRYAERFPDPAEPEPDFGPDTDGSPLRPPGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8X0</accession>
    <name>A0A231H8X0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776755.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45252">
        <property type="protein sequence ID" value="OXR45252"/>
        <property type="gene ID" value="B7C42_02377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="96" mass="10869" checksum="ADB40813992E610A" modified="2017-10-25" version="1">MTTRLEHNTAAGRYEIYIDDTLAGYADYNESSAGEKPIRDLNHTLTFPEFRGRGVAAQLVDYALTDCRDNGFAVVPTCWYVEQYIGDHREYADLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9N0</accession>
    <name>A0A231H9N0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Doxorubicin resistance ABC transporter permease protein DrrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">drrB_5</name>
        <name evidence="9" type="ORF">B7C42_02690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45565">
        <property type="protein sequence ID" value="OXR45565"/>
        <property type="gene ID" value="B7C42_02690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="29173" checksum="A313790B0BFB822A" modified="2017-10-25" version="1">MSAPVAAEARLFAQMPEARISSFAQWRALTGRIVRTMATKGELVVAVITPLVFTLGFYLPLRYVMQFRGIDYAQFVMPIIVLQTMSFTMMSNAQIAAFESMTGLHTRMQTMPIGPMVPLTSRMCAGLVRSVTSLIAALIFGYMIGFRFTAGLGQAVLFCAFSLAVGTVLAIGADALGSFTKSPEALSQALTLPTLILGMLSCGFVPESGFPAWIRPFARNQPVSQFSFALRDMAAGGVSWHVLWVPLVWLISLTAAFVPLAVWASVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA46</accession>
    <name>A0A231HA46_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent hydroxymycolic acid dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd2_3</name>
        <name evidence="2" type="ORF">B7C42_01984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45692">
        <property type="protein sequence ID" value="OXR45692"/>
        <property type="gene ID" value="B7C42_01984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="30751" checksum="4844BD29D6FE70A1" modified="2017-10-25" version="1">MGGPQWYLFLPQIRLDMGDIVARARAAEAGGFDGIAFIDHLRAPGAEQQPLWEAMTVAAWVAARTERLRIGHLVLCDSLRHPALLAKQAVALQEASGGRFELGLGSGSVPKELADFDISHEDGPARQARLARTLALLPRYWAGVGELALAPAPTSRIPIVIGGSGPATMALVRRYADWWNLPANHLDRLPRLRAKAGSARVSTQQLVGFAGRGADPDQVRALSLRRFGYLASGLVCGNAEELIAHFAAAVEQGVERFYVWFTDFAQPDTLAEFGAAVIAALRGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAR0</accession>
    <name>A0A231HAR0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG3_3</name>
        <name evidence="1" type="ORF">B7C42_02231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45938">
        <property type="protein sequence ID" value="OXR45938"/>
        <property type="gene ID" value="B7C42_02231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="229" mass="23824" checksum="6D07615DE5D5C6AA" modified="2017-10-25" version="1">MGAAHARLLVAEGAKVVIGDILDDEGAALVGELGDAARFVHLDVTAPEDWAAAVSTAVGEFGKLDVLVNNAGIVNGNSLRKFELEQWRRILDVNLTGTFLGMQAAVDPMIAAGGGSIVNVSSIEGLRGAPWAHGYVASKWGVRGLAKSAALELAQHNIRVNSLHPGLIRTPMTAAIPDDLVTIPLGRPAQPEEVATFVLFLASDESSYATGSEFVVDGGLVTAVPHKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB34</accession>
    <name>A0A231HB34_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">grpE_1</name>
        <name evidence="3" type="synonym">grpE</name>
        <name evidence="8" type="ORF">B7C42_01108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781460.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46143">
        <property type="protein sequence ID" value="OXR46143"/>
        <property type="gene ID" value="B7C42_01108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="22588" checksum="68D23052B66CBE11" modified="2017-10-25" version="1">MTEQNPKEEPVTIVDNRKIDQDGKPSAPQGDVSEAAAGNDTASASASAAEGDALADSISAELSERTADLQRLTAEYANYRRRVDRDRKAAIDSAKAAVVTELLGVLDDLDRARAHGDLESGPLKSVADKLADALQKQGLEEFGAEGEPFDPTLHEAVQHEGEGHNPVIGVVMRKGYRFGDRVLRHALVGVTDGVADLSDSSDTANAGRDADGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB80</accession>
    <name>A0A231HB80_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ligC</name>
        <name evidence="4" type="ORF">B7C42_02270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45977">
        <property type="protein sequence ID" value="OXR45977"/>
        <property type="gene ID" value="B7C42_02270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="107"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="40648" checksum="57A83E52578BA82D" modified="2017-10-25" version="1">MDLPVMPPVKPMLAKSAGALPREDTLLYEPKWDGFRCIVFRDGTDIELGSRNDRPLTRYFPEVARLLDAALPPRCVLDGEIVVVTEHGLDFDVLQNRLHPAASRVNKLSVETPASFVAFDLLALGDDDLTTRPFHERRHLLESILDTPHEGIHLTPITSDPDTAQDWFTRFEGAGFDGVMVKSRDLPYMQDKRVMVKVKHERTADCVVAGFRWHKDGEGVGSLLLGLYDEDGNLHHVGVASSFTAARRRQLVDELAPLREGALDNHPWRTWADAAAQAKAEGKMPGGISRWTGGKDLSWEPLRPELVAEVRYEHLMAGRLRHGGRLVRFRDDRTPQSSTYAQLEEVAPAELADIFTAAKAQAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBU1</accession>
    <name>A0A231HBU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sepiapterin reductase</fullName>
            <ecNumber evidence="2">1.1.1.325</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.325" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46305">
        <property type="protein sequence ID" value="OXR46305"/>
        <property type="gene ID" value="B7C42_01271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="25936" checksum="9671BE8728F47FAF" modified="2017-10-25" version="1">MPGAGGVYGEHMAATSESSAAQDVPTALITGAGRGLGAAIARELAGTHRLLLGARSAESLAAIRTELPDAEPWPVDLTDYAALPAATASIERLDVLVHNAGVAELGSIAESSVEQWRNTLEANLIAVAELTRLLLPALRAANGHVVLINSGAGLRANPGWGVYAASKFGLRAFGDALRLEEPNLRVTSVHPGRIDTDMQRAIVASEERDYHPGEFLTAATVARAVRNAVETPRDAHPTEIVLRPIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC77</accession>
    <name>A0A231HC77_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2OG-FeII_Oxy_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781704.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46356">
        <property type="protein sequence ID" value="OXR46356"/>
        <property type="gene ID" value="B7C42_01322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OG-FeII_Oxy_4" evidence="1">
        <location>
            <begin position="165"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="28290" checksum="C83168699B236B3B" modified="2017-10-25" version="1">MLSEAPLPRWFIDLLAHRRWIRRTRPFPHVYVRDVFVAEFYQRLAAEFDRVRSERPDLFGPVAAGYGASGASLTRMRNGPLEVFLSRAWHDLIERVAGVSGSGDVEGSVHHHPPGSPRGWPHHDLTPAWFPGAEPGPEAVGLPADDIDLKSGARPAGVPAREMVRAVAVLFYLGNGEWQPGDGGETGLFADIGTADPAPTVVIPPLDNSMVVFECTPRSWHTFLGANTAARNSVVMWLHRPKEQAASRWGGDRIVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCI8</accession>
    <name>A0A231HCI8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase LipF</fullName>
            <ecNumber evidence="3">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lipF_1</name>
        <name evidence="3" type="ORF">B7C42_01571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46600">
        <property type="protein sequence ID" value="OXR46600"/>
        <property type="gene ID" value="B7C42_01571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="109"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="37048" checksum="C982A62869675305" modified="2017-10-25" version="1">MTAIPIGEAEYGPGFEPGVVVDPVVVNPDRSSLHSQAVLLTCRNVVGPVIRRYPITPMTMPVARVLIDRLAALRPQVRGVEREQVRMSGFRMEIIRPAGARRSLRDGAVMYMHGGGFFLCGLDSHRPVAASLARRTGLPVVNVDYRQLPGTNIAGSVEDCLTAYRWLLRHGADPARIVFAGDSAGGFLTFATALRAAQAGLPGPAGLVGLSPLLDLDYRLKGEYMNVGRDAYIPMAAVRQMVRYGAEAERPLDPALSPVNGSLTGLPPALLIVGEDELLRCDSELMARRLTAAGVPNSLELWRGQVHAFMSILPNMPESRAALARVARFVRARVEPEEAARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCK0</accession>
    <name>A0A231HCK0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46683">
        <property type="protein sequence ID" value="OXR46683"/>
        <property type="gene ID" value="B7C42_01658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="94" mass="9514" checksum="DB3F06706658925E" modified="2017-10-25" version="1">MTAPAPAPAPAASQVRHPGRAVARTVLQLAVGITAATPELVYLSGVPANTSAVVVGLGVAAAFTRFMAIPQVEAAIQTWAPWLAAEPASGRQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCL3</accession>
    <name>A0A231HCL3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46630">
        <property type="protein sequence ID" value="OXR46630"/>
        <property type="gene ID" value="B7C42_01604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="25506" checksum="941737635C7B5BAF" modified="2017-10-25" version="1">MTGAQCSRCPRQVVQLRRGMCPACYEAHRYRMKAYGRWTPDRVNAAPVRAHVAMLQNAGLARKAIARRAGIAPQVLDNVMIGKRSRKPARTVTAKTAAALFAVTLDQADPAGREFVSAIGSQRRIRALVAFGYTLTALAAELGLPRTALTPVLTRQTTVRVWRHDEIKALYERLELTPGPSEAARRMGRERRWPLPFQWDEDALDDPNAPTPDSRLRREPYRPRAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD10</accession>
    <name>A0A231HD10_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_01706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46729">
        <property type="protein sequence ID" value="OXR46729"/>
        <property type="gene ID" value="B7C42_01706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="578" mass="62467" checksum="1B72C75AD1E198EF" modified="2017-10-25" version="1">MLIRLLRAFLAPYRTQLVGVVVLQLISVIAMLYLPSLNADIIDNGVTKGDIGYIWTTGLWMLLVSGVQIVASASSVYLGAQAAMGAGREMRAALLHRVGTFSAREVGIFGAPSLITRNTNDVQQVQLLVVMSVTILVMAPIMCIGGIVMALRQDLGLSWILLVAVPLLGLTMALIISRMVPGFRRVQERIDAVNRVLREQITGIRVVRAFVRERYESRRFGVANDELTSASLFVGRLAALMFPAVMLISNVTTVAVIWFGGHAIDSGSMQIGSLTALLSYIMQILMAVMMASFLAMIAPRAAVSAERIAEVLETDSSVVPPAQAQTFVADPGTVELTAAEFAFPGAAEPVLRDISFRVSPGQTTAIVGSTGSGKTTLINLIPRLIDVTSGVVRVGGTDVRQVDMELLRSQIGLVPQKAYLFSGTIAENLRYGDPEATDDQLWHALEIAQAADFVRDMPEGLQTPVAQGGTTVSGGQRQRLAIARALVKKPKIYLFDDCFSALDVATDARVRDALRPETRESAVITVAQRVSTIRDADQIVVLEDGAMVGLGTHEQLLRECEEYREIVESQFSPEEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD32</accession>
    <name>A0A231HD32_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate 5-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gno_1</name>
        <name evidence="1" type="ORF">B7C42_01808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.69" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46830">
        <property type="protein sequence ID" value="OXR46830"/>
        <property type="gene ID" value="B7C42_01808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008874">
        <property type="term" value="F:gluconate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="24897" checksum="F7D34293F7E52921" modified="2017-10-25" version="1">MSASSTGIPRVVVMGGSSGIGAATAALFANEGAEVVVTGRSQDKLDAAVARLGGKISGYRMDATDAEQIAAFFAQSGPIDHLVVAVSGSAGSGPFAELDLDHLAQGFDGKFWPQVRIVKAALPHLVSDGSITLITAASAHAAFPGTAGLAAINGALNAMVPPLAVELAPLRVNAVAPGVIDTEWWERVPQEQRRTLFDGLAATTPVGRVGDPEELARAVHMIATNGFVSGVVLDVTGGANLPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD83</accession>
    <name>A0A231HD83_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein YdfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydfJ_1</name>
        <name evidence="8" type="ORF">B7C42_01702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46725">
        <property type="protein sequence ID" value="OXR46725"/>
        <property type="gene ID" value="B7C42_01702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="231"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="769" mass="81719" checksum="66C43A668618D396" modified="2017-10-25" version="1">MSVYLYRWGRFAFRHKWIVLPVWLILFVIIGSLGTQLKKPMNDDFTIPNLPSERATEIMDKHFPGMSQAFSFEAVTGTYVFGAAPGQKLTEASQRAAVAGTVTKLNDLNIVDHKTPLVDPITATEQMGCFAADRSSPEFVSRCSAAPVNVLNKENPDTVAVLTVPFTIQKFTDITADDRAAAYAVGDDARAAGLQVEMSGSLAMEQQQPSGQAEMIGMAVALVVMVVAFGAIVAAFVPIITAIVGLGLATSVIFLGTSFMSVPSFTTFLASMIGIALSIDYALFIVSRYKHERAVQSSPEIAAGTALGTAGSAVVFAGATVIIALVALAIVNIRFLTFMGLGGAIAAAFAVLTAITLMPALLGAFGKYLFTPKLPVIAQHDPEDDSEVTNGMRVARVIGRMPWLTLVASIIVLGLLAAPALSLNLGLPGEDSQPRTTTIRKAYDLRTEGFGAGSNGKLQVVADLSQVPADQRRAALTALHDELAAYPGMDYVTQPQSSRDGAGALMTAVPTTGPNDQATKDLVRNARDAESSLHDRYGIDYGITGTTAIYADVDHALLSKILPYLAIVAGAAFLLLIAVFRSVLVPFTAALGFLLSMAATFGATVLIFQKGALGLISEPRPIVSFLPIMLIGLVFGLAMDYQVFLVTRMREEYVHGKSPTDAMVSGYHHGARVVTSAAVIMISVFGSFLLESDATAKSMGFALAAGVLFDAFLVRMVLIPSLLVVMGKAAWWIPGWLSRIVPDIDVEGARLRELHVDDPDEPRSPVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDG0</accession>
    <name>A0A231HDG0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ribonucleotide transport ATP-binding protein mkl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mkl_1</name>
        <name evidence="6" type="ORF">B7C42_00050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46934">
        <property type="protein sequence ID" value="OXR46934"/>
        <property type="gene ID" value="B7C42_00050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="351" mass="37866" checksum="AC020FB3A4EEEF9F" modified="2017-10-25" version="1">MAGLEIVVEGLTKSFGPQTIWADVTLTLPPGEVSVLLGPSGTGKSVFLKSLIGLLTPERGSIVIGGTDIVRCTSAELYEVRKLFGVLFQDGALFGSMNLFDNTAFPLREHTKKSESEIRRIVMEKLELVGLLGAEFKLPGEISGGMRKRAGLARALVLDPQILLVDEPDSGLDPVRTTYISQLLIDINAQIDATVLIVSHNINLARTVPDNIGMLFRRELVMFGPREVLLTSDEPVVKQFLNGTMIGPIGMSEEKDEAQIIHEQAMVDAGHHHGGVDHVEGIVPQLQPTPGMPIRQAAARRQERVHAMLHSLPLSAQTAIIDSLAELGGPDPGDEPSGSPQAVRIRGTDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDJ7</accession>
    <name>A0A231HDJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcC_1</name>
        <name evidence="3" type="ORF">B7C42_00090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46974">
        <property type="protein sequence ID" value="OXR46974"/>
        <property type="gene ID" value="B7C42_00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="11381" checksum="8D2794317A60D09F" modified="2017-10-25" version="1">MAKVTYVRPKGDDVIVEVPDGTTVMQAALANDVSEIVAECGGTLACATCHVYVDDNDIQRLDAPSADEDEMLGYTASPRLPGSRLSCQLVLGPELDGLVVRVAPEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE45</accession>
    <name>A0A231HE45_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47129">
        <property type="protein sequence ID" value="OXR47129"/>
        <property type="gene ID" value="B7C42_00251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="10698" checksum="54B2DF97886C760B" modified="2017-10-25" version="1">MPPEAVTELVIAYQAGIPTTELCKRYDISKASILKLLAEHGVTMRRQPLTTDQINQAAKLYADGNSLRTIAVQLDSSFSTVREALIARGVQMRPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HER3</accession>
    <name>A0A231HER3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47352">
        <property type="protein sequence ID" value="OXR47352"/>
        <property type="gene ID" value="B7C42_00475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="30976" checksum="CE62D8F289CE85EF" modified="2017-10-25" version="1">MRVFITGASGHVGSAVVPELLSAGHEVVGLARSDVSAAALEAAGAQVYRGNLDDPEALAEAAAAADGVIHLAFKHENMIAGDFLGAADADLRVVRAFGDALAGSGKPLVSTSGTGLLAALGRTGTEADSLPGGPRIDSENEVIGFAERGIRSSVVRLPPTVHSTLDRHGFVPTLIAIAREKGVSAYVGEGVNRWPAGHTLDAANLYRLALESAPAGSRLHAVGDEGIPLRRIAEVIGRHLDVPVVSIPAEDAPGHFGFLAPMVQLDSPATAEATTALLGWKPLHPNLIEDLEEGHYFTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEZ3</accession>
    <name>A0A231HEZ3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">ftsY</name>
        <name evidence="9" type="ORF">B7C42_00635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47510">
        <property type="protein sequence ID" value="OXR47510"/>
        <property type="gene ID" value="B7C42_00635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="326"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="408"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="470"/>
            <end position="473"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="518" mass="53735" checksum="94C91C5A9EF4BA70" modified="2017-10-25" version="1">MTAQAWILIAAIVAVLLVAFVAGFVLYKRRRVSITPAQEQDKQLTDRSGGYTAAGGFNFSQGGAGSGTLTPPRPEPVPIERTDDEGQPHVGDDAAIPRDSVRRTITDVRLPEPETLADRPADGASATAPTVEPETTETPGDGVAAPEAPAEAPAAPPSTDGATAVTPAPVETPESAPVDSAPTTAPSAPTTPTPTAPTPTAPAPQPTAVEEIEPTAGRLTRLRGRLSRSQNAVGKSLLGLLGGGDLDEDSWEEIEDTLVMADLGTSVTTTVVERLREELAARSVRTTEQARQVLRDVLIEALRPDLDRAIRALPHADHPSILLVVGVNGTGKTTTTGKLARVLIADGRRVLLGAADTFRAAAADQLQTWGERVGADTVRGREGADPASVAFDAVSTGIEEGVDAVLVDTAGRLHTKTGLMDELGKVKRVVEKKAAVDEVLLVLDATVGQNGLTQARVFAEVVDITGVVLTKLDGTAKGGIVFQVQHELGVPVKLVGLGEGADDLAPFEPSAFVDALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFH7</accession>
    <name>A0A231HFH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47733">
        <property type="protein sequence ID" value="OXR47733"/>
        <property type="gene ID" value="B7C42_00858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012398513" evidence="2">
        <location>
            <begin position="45"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="419" mass="44123" checksum="068606FB2A5B23A1" modified="2017-10-25" version="1">MPISGCLARAIISWPMGHTAVRRALSVAAGSLLLFAAATTSAPAQPIYPAPDPDPFYAAPADIAEHKPGDVLATKPLPPLDIFPDTDITLIKFRSTNSEGKPIAATTTVLTPRKRAADGPLLSYQTIINGLGTDCGVSHVLYTKNPDLMVREAPAYNVVLQRGWSIAMPDHLGPQFAYGAARLGGQITLDGIRAVQRAADLKLEHSPVTMAGYSGGGMATAWAAALAPAYAPELRIAGAAAGGVPMNMVKMLEGLGYGSHPAFGLAMAAGLGLEREYPDRFPLSEQLNDKGLAARQVMADSCTNGLLAAGAGHGVTEFARTTSMTEDPVARKVVEDNSLELYTDSVPNMPVFEWHSPIDGLIPVDSIIATDRRWCQAGVSVQSEAIPVPDHLTAAVLGLPQVLNWLDGRMHAQPVPSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFJ5</accession>
    <name>A0A231HFJ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L3 glutamine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.298</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prmB</name>
        <name evidence="3" type="ORF">B7C42_00845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.298" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779471.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47720">
        <property type="protein sequence ID" value="OXR47720"/>
        <property type="gene ID" value="B7C42_00845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="216" mass="23254" checksum="17A71ED7D3C52494" modified="2017-10-25" version="1">MRLFRAPGVYAPTADTGLLIRALGAAAIPEGSKVVDVCTGTGAVAIEAGRAGASAVTAVDISRRALASAWLNSRLHGVPLELLHGDFGRVLRRRTFDAVLANPPYVPGPSEAPARGRARAWEGGPHGRALLDPLCRLMPELLRTKGIALIVHSSLCDPDLTVRQLRDGGLKAAIVVRETCEFGPVLRRRADWLEQQRLIEPGARQEELVVIRADRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFL4</accession>
    <name>A0A231HFL4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_00600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47475">
        <property type="protein sequence ID" value="OXR47475"/>
        <property type="gene ID" value="B7C42_00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="64"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="181" mass="19192" checksum="3483470BE71757AD" modified="2017-10-25" version="1">MVVLYPAPPGMWVNPQPDPGVSIVHSELLAETPEPQQSPPRIRRLGSRFATYLRGDHWLPQLVRFALVGGFSNIGYFLLFLACYGGGPQLANLTGSIVSTALANELHRRLTFHAADRVGWLAAQLEGGGLALAGLAITSGALAVLDIAAPGLDDVTEAIAVIGITAGVGALRFLTLRLWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFP1</accession>
    <name>A0A231HFP1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tatA_1</name>
        <name evidence="7" type="synonym">tatA</name>
        <name evidence="9" type="ORF">B7C42_00916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47791">
        <property type="protein sequence ID" value="OXR47791"/>
        <property type="gene ID" value="B7C42_00916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="92" mass="9592" checksum="7DA42E8584FE52B5" modified="2017-10-25" version="1">MGSLSPTHWLIIALVVVVLFGAKRLPDTARGLGRSLRIFTSELSEMHSEDSGSPNTASASVPDAGHRAAPAAPLPPGRPATPSSAVEDRHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFQ6</accession>
    <name>A0A231HFQ6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_00662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042869.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47537">
        <property type="protein sequence ID" value="OXR47537"/>
        <property type="gene ID" value="B7C42_00662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="12603" checksum="70342A823C289EA0" modified="2017-10-25" version="1">MTAIPPNRPPAVPADRGLQAERTALSWWRTAVGAMANALLFLHVALTSGDRAATVLALVAIGALAVITTVCVARSRTLHAHAWGRWSDGWLAMATTSAAICVVASAALVVALLESTPGWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFU7</accession>
    <name>A0A231HFU7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
            <ecNumber evidence="1">3.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynB_1</name>
        <name evidence="1" type="ORF">B7C42_00680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47555">
        <property type="protein sequence ID" value="OXR47555"/>
        <property type="gene ID" value="B7C42_00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="30560" checksum="B896B620EE810846" modified="2017-10-25" version="1">MCAPELIDSVASPCGLVAAPPRPARRGFLKTLATGLVVGAAGVVTTGASPVQAASGRGRGFGRVVDLTHTVTPDFPVWTQVSKPPQLIPVARMAENRYNGDEIVTYEHVGTHVDAPLHFSDGGLSVDRIPADQLVAPLAVLRIADRAARDPSAVVTVADIRAWEATHGPLPDGAFVAMDSGWSRRISVPGAYLNYDERRNVYRWPGFSAEAADFLIRQRRVVGIGVDSTGLDRGSDHAVPVHRSWLPAGRYGVESLADLDQVPDAGATLIVGAPKHGGGTGGPARVFALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG30</accession>
    <name>A0A231HG30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47686">
        <property type="protein sequence ID" value="OXR47686"/>
        <property type="gene ID" value="B7C42_00811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="26114" checksum="84C4C2665145CD52" modified="2017-10-25" version="1">MRRGRCRPLRPPPRPRGNRSPNPLSGTVFPIRSRLRRLRRKALRPASRILHRRARPDPLRLRGQSAKPRNVDHPRSHPVRRTMRARTGAPGPRGAGFCAVVGRRLPVAGLAGAVWHAITKPTAADRHSIADRTRTVRAFTASSTKPMSRTAGPPPGRTPDHAKPVETRASVIVRPARARCGVLRPTAPPRTISSPAPGGFRVRYATPGNSPYTRSGSGSTRESGNFAAGGGCGGAASAGARPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG41</accession>
    <name>A0A231HG41_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-phenylpropionate/cinnamic acid dioxygenase subunit beta</fullName>
            <ecNumber evidence="2">1.14.12.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hcaF_1</name>
        <name evidence="2" type="ORF">B7C42_00944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.19" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042846.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47819">
        <property type="protein sequence ID" value="OXR47819"/>
        <property type="gene ID" value="B7C42_00944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008695">
        <property type="term" value="F:3-phenylpropionate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="182" mass="21149" checksum="C55A649299BDEFB5" modified="2017-10-25" version="1">MTQQQTVAQRRLASNDPRYAEVVDFYFYEAELLDDLNERQWLTDLVSRDILYQVPIRETVERARGFGFSDMSYHLNENLGSLESRVARGETAYAWAEDPPSRVRHFVSNIRVLEHDSGDADLIVGRSNTLVYRTRQDQTAPQMLSGERRDVLRREGGRLRLLHRVVHLDLTVIGTHNLSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT32</accession>
    <name>A0A231GT32_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000082">
        <property type="protein sequence ID" value="OXR39705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39705">
        <property type="protein sequence ID" value="OXR39705"/>
        <property type="gene ID" value="B7C42_08219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="10679" checksum="1E0E5F583B31FF0C" modified="2017-10-25" version="1">MAGNMYFNFAHVDEHHTTLKGLGQAMEDNVNHLRNLQQTLASLLGGATSEAYQEVSGNLNKLLAAHQANLVKLNTQIHFAAGSQGMVQTADKASAASMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTC4</accession>
    <name>A0A231GTC4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxosteroid 1-dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ksdD_2</name>
        <name evidence="5" type="ORF">B7C42_08049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778608.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39874">
        <property type="protein sequence ID" value="OXR39874"/>
        <property type="gene ID" value="B7C42_08049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047571">
        <property type="term" value="F:3-oxosteroid 1-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="567" mass="60432" checksum="7C0B643EDD953D73" modified="2017-10-25" version="1">MAKKPMPPLTTAHEVTVDLLVVGSGTGMAAALAAHEQGLSSVIVEKTAYVGGSTARSGGAFWIPGNPSLPDSDPDLAEARAYLRSVVGDTAPAERGQAFLDAGAAAVEMLERTTPMRFFWAKGYSDYHPEEPGGRAEGRTCECRPFDASILGEQRPRLRPGVMEAPVPMPVTGADYKWMNLVARKPIKAFSRILRRAALGIGGMVVGREYLAGGQALAAGLFAGVLRAGIPVWTETSLVRLIREGDRVAGAVVRQGDREVTVTARRGVVLAAGGFDHDMAARHKFQSPRLDDDASLGSEGNTGDAITAAQELGAGTALMDQAWWFPAFAPLPGAAPLVMLAERSLPGSFVVDQTGRRFVNEAMDYMSFGQALLARERRGDPAEQMWLVFDQRYRNNYILAGQYFPRQPLPQAWFEAGIAHRADDPAALARAIGVPEDAFTETFQNMNRYAESGTDPEFARGASAYDRYYGDPTVTPNPNLAPLRKAPYYAVKMILSDLGTCGGVVADRDARVLREDGGVIEGLYAIGNTAANAFGASYPGAGATIGQGLVFGYIAARHAAGETTESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTC9</accession>
    <name>A0A231GTC9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782310.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39887">
        <property type="protein sequence ID" value="OXR39887"/>
        <property type="gene ID" value="B7C42_08033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="128" mass="14049" checksum="993CB99EB42C7834" modified="2017-10-25" version="1">MPSQLNRVDMVPSDQWSVIDAAGQLVWAHNIDGGLIATYWAADLEPDEGYCLIRTDTLPDQHSVNPGPGQILAPYWPRSAGVEGAYPYINSEVFLWVARVALVPDYAIEGVTPAVTYPLNRNITPPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTD5</accession>
    <name>A0A231GTD5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent monooxygenase, reductase subunit HsaB</fullName>
            <ecNumber evidence="3">1.5.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hsaB_5</name>
        <name evidence="3" type="ORF">B7C42_08054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.36" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042675.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39879">
        <property type="protein sequence ID" value="OXR39879"/>
        <property type="gene ID" value="B7C42_08054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036382">
        <property type="term" value="F:flavin reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="183" mass="19485" checksum="26E0155E51091B0E" modified="2017-10-25" version="1">MARASENGGLAASDYKAVLGHFCSGVTVITAISADGPVGFSCQSFSSLSLDPPLICFCPARTSSTWPHIRESGQFCVNILAADQQGLCRQFAMSGADKFAGITWHPASNGAPRLEGAIASLTCALEREVDGGDHTIVIGRVIEAEVQSVRPPLLFHRSAFKQLAPEPDPRSSALMPLDTWRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTU4</accession>
    <name>A0A231GTU4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan endopeptidase RipA</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ripA_4</name>
        <name evidence="5" type="ORF">B7C42_07889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40044">
        <property type="protein sequence ID" value="OXR40044"/>
        <property type="gene ID" value="B7C42_07889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511454" evidence="3">
        <location>
            <begin position="37"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="225"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="38731" checksum="E6573FF50E319326" modified="2017-10-25" version="1">MMSSTRTVVAAVVSLPLALIMLLAVLVGIQSADSCAAPLLAGGVTGPSGQSMAALSERQLELARNGVAIGKQRRQPESVIIAELAAMITESTLRNLANSNVPESLSFPNDGVGADHDSVGPHQMRVSVWGRVGIAALMNVAYQINWFYDQAATITGAASMSSAELAQAVEVSAPNAYAGQLGLARRLYAMFAGIDPGASLAGEPGQPPTGCGPGSAPPGAPVPASGFGQAVVAAAQRWIGTPYVWGGGDTNGPTGGGFDCSGLTLYAIYQASGGRIRLPHYTQAQQDDPAALPVPFDQRQPGDLIFFTTVGESDSHHVAVYAGRAADGTDLVLHAPQTGQTVTTAPLARVAGSDHLDVRRYSTPQPRPPTVAEGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU58</accession>
    <name>A0A231GU58_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase</fullName>
            <ecNumber evidence="1">1.1.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hsdA_4</name>
        <name evidence="1" type="ORF">B7C42_07786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.50" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778621.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40122">
        <property type="protein sequence ID" value="OXR40122"/>
        <property type="gene ID" value="B7C42_07786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047042">
        <property type="term" value="F:androsterone dehydrogenase (B-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="29816" checksum="8536105C0AB6831B" modified="2017-10-25" version="1">MGVYVVTGSASGMGRAVADKLRRDGNTVVGVDLRDAEVVADLSTAEGRRAAVDGVLAVVDGHLDGAVMAAGVGPAPGTERPRLIYEVNYRGVIELLQGWRPLLAAATDAKVVVFGSNATTTTPAVPGRAIRALLAGDTDKALRAVRIFGQNAPSFAYAASKIAVSRWVRRQAVTAAWAGEGIRLNVLAPGAILTPLLEKQLATPREAAAIRQFPVPIGGFGDAGDLADWVLFMLSDAARFLCGSVVFVDGGSDAYFRADDWPRAVPVRKIAGYLRRFRGFSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUB3</accession>
    <name>A0A231GUB3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40071">
        <property type="protein sequence ID" value="OXR40071"/>
        <property type="gene ID" value="B7C42_07875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="31579" checksum="3864B20410C342A8" modified="2017-10-25" version="1">MSDNTFPATHLPDVSAPDPTASSTPSDAAPPPAVPPTAFRSRTVASALAVRFGPDDPDAVRATALRAVQDSVKRYIDWQHHPAPGTSAAGPGEWRLTAINGIEDDLRRAYLDAVHSGVPISEINTAHDLGLAGVGWNQQPAHPLLGRLEHLAHELTLAEARAGTDRARIRELENELDHSHTRIETLSEDLAHARNTIARQTEELVDADWLTGHRHHNTEPGPQPARALAQTNAELALANDIDALERTTSLDTSGWISTAIDTALPGQPDYWPDTTDPDTGPPPSTMDHGPEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUB9</accession>
    <name>A0A231GUB9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">atpA</name>
        <name evidence="15" type="ORF">B7C42_07735</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40220">
        <property type="protein sequence ID" value="OXR40220"/>
        <property type="gene ID" value="B7C42_07735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="14">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="12">
        <location>
            <begin position="152"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="13">
        <location>
            <begin position="382"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR40220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="545" mass="58523" checksum="6C8CD80D1E7E53C3" modified="2017-10-25" version="1">MAELTISPDEIRSAIESYTQSYTPETSIEEIGTVTDTSDGIAHVSGLPSAMTNEILEFPGGVLGVALNLDPDEIGAVILGEFDGIEEGQQVRRTGDVLSVPVGDKFLGRVINPLGQPIDGLGEIEADERRVLELQAATVLERQPVEEPMATGITAIDALTAIGRGQRQLVIGDRKTGKTAVCIDAILNQKANWESGDPTKQMRCIYVAIGQKGSTIAGVKSALEAHGAMEYTTIVAAPASDSAGFKWLAPYTGSALGQHWMYQGKHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDAMGAGSMTGLPIIETKANDISAFIPTNVISITDGQVFLESDLFNKGVRPAINVGTSVSRVGGAAQTKGMKKVAGSLRLELASYRELEAFSAFASDLDAASLAQLERGARWVELLKQDQYSPVAVEDQIVSIYLVDAGFYDSVPVGDIRRFNSELLETLHRAAPQAFESIAGGKVLEGEAADAIKTETERFKQGFLASDGSRVVNEADAGELDHEEVESLSVTRKHVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUI5</accession>
    <name>A0A231GUI5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40238">
        <property type="protein sequence ID" value="OXR40238"/>
        <property type="gene ID" value="B7C42_07663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="21171" checksum="6021CF50A1734F0D" modified="2017-10-25" version="1">MFAVVLDTCVLYPSVQRDFLLSLAVEGMYRPLWSDRILEEVEYTETDKLIAQQVDPIEAEEQARGLVEQMRSNFDDALVQGWEPLDGSFGFKDRKDEHVLAAAVVGGAGAIVTANVKDFPVDKIPGHIQIIRPARFSADTVSTSPEGALRALQQMSKRRQNPPQTVDDLLQILENRYGMSEVVELIAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUP4</accession>
    <name>A0A231GUP4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaerobic sulfatase-maturating enzyme</fullName>
            <ecNumber evidence="8">1.1.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">chuR</name>
        <name evidence="8" type="ORF">B7C42_07608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909896.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40347">
        <property type="protein sequence ID" value="OXR40347"/>
        <property type="gene ID" value="B7C42_07608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="628" mass="68442" checksum="8302327DD5F982B8" modified="2017-10-25" version="1">MEAATPAADLSRRVYLTLPDTEDTAAVSVILKLRGETCDIDCVFCYEKRKEAPGGARIGADDIGRLAELFGDRPVAIELHGGEPLTVGKRQMREILAALAAQESVTRVTMQTNGIRLDGEWLDLFDEVYPDLHIGISLDGDPEGNSWRVGYDGRETYTKVAQSLRLLERRGRRTGIITVVTPRVLGRAAEVLDHLAGFAAVNAISLVPCFDSSVIAPTAASTSRVSASRLLQRDALSGGSPAWSITGDEYAQFVLAAAVHWVTAGLFSRIKLEPVVSTIRALKGLEVGFCHFSNLKCDHVFTLYPDSRFGSCDELPWPAAQLGHLSELSDANGIAEAQYRLPLLAEGRSLAAKCAACRYRDTCGGGCIATRLRAAQAAGSDDDYCRYRSRLIDGLAALTIQPEIPSAVWCHRVKARPHQPNLMADVPGFMRRWRDPEAARGSVRLEVSDHGNINTLGRPGIHEADDLDPLHPLWRDAIEPGVWPLVDPITREWGLVTYDSCQGHHYGGLELAPVERRVGILPRDRREYASTAAALCRLVAAVEAELPPSIRIVVGRAELTCSTTGSRFPVLDLRFECPEKQAWEAYFADLDTATAILAGQFDAPSPAGRTTCGCSEPYTSGRHDEQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUP7</accession>
    <name>A0A231GUP7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_07715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776369.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40201">
        <property type="protein sequence ID" value="OXR40201"/>
        <property type="gene ID" value="B7C42_07715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="188"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="44737" checksum="643CB09B98773FCE" modified="2017-10-25" version="1">MRQQLPPQITKVTVTDRSTKKPVVRYQVVADAGRDPVTGKRHQIRRRYRTEKEARKALADFTAGAAAGTFVPRRDVTVDEVCRDWLDSLHWARRTTLAGYQYNLAPLREQYGTIPVQKLTRKHLDDLVAALKKGGTVTEKGKVRRPWAARSLKRTVETTSMVLDYAIERKLLGHNVARAIKPKAGKKRKPVTYTPAEVSRFLLSLETDRDGHLWFLALCGLRRSEIGGLRWSGVDFKRKMLTVHIGRAAAGGKAVEDDPKTESSIRELPMDDEMVEVLKRARRRQAADKLQLGEAYQDLGYVACNEDGTPYHPDTLTHRWARAVKRAGVRHIRLHDARHTCGTTMHLRKVPLAVIAAWLGHADASVTARIYTHSQADALRDAARSLGEVVTTRDTEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUU2</accession>
    <name>A0A231GUU2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450 107B1</fullName>
            <ecNumber evidence="5">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40352">
        <property type="protein sequence ID" value="OXR40352"/>
        <property type="gene ID" value="B7C42_07518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280091" evidence="4">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="434" mass="48169" checksum="26F32E36050DD0D7" modified="2017-10-25" version="1">MTVVHSVRGVTSALKPVTSALHMNVAGALLNRRRGYRAWTGATNTDYDPLDPATAADPFEAYRTLHDTGRVHYNPERATWILSKLDDIRTALRSTDQMTSTQGVTRIRMAGDVVVLTDGERHTQLRRQVQPGFTKKALESWRQISDSIAEELVTAMLREPECDVVQRLAVPMPLRLIAGILGVPDTDIENFRNWSENAVKIIDFSPTPAGLAGVARSVRAVLALRRYFRAQLSSGNLKGSDTILGRLLESDRETSLTDENLFYIAMLLLIAGNETTTNLLGGMFDTLARHPDQYDLIRSDPTMIPMAIEEQLRISSPIQNLYRYTRADFELGAVTIPSGSRVLLSFGAANRDPAVFTDPDHYRADRNPRMHMAFGHGSHMCLGAPLARMEAQAVLQQLVNRVDRIVATEPTTWSTNSSLRGPTRLPIRLIPSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUY2</accession>
    <name>A0A231GUY2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carnitinyl-CoA dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">caiD_9</name>
        <name evidence="6" type="ORF">B7C42_07495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.149" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40437">
        <property type="protein sequence ID" value="OXR40437"/>
        <property type="gene ID" value="B7C42_07495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23101" checksum="B569FCFA88E99D82" modified="2017-10-25" version="1">MTAGLDAAFDEFEDDPDLWVAVLTGTDQVFSAGTDLTGGSGEPTARGGEYGLIRRRRRKPLVAAVEGHALGGGMELVLACDLVVAATTAVFGLPESRRGVIASCGGLFRTARALPLNIAKELLLTGDALTAERAHQLGFVNVLTETGSALTAAVELAQRISGNAPLSVRESLAALEELNSADDDRAWEITEAAMAATLSSRDTSEGVAAFLARRAPHWRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUZ9</accession>
    <name>A0A231GUZ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40450">
        <property type="protein sequence ID" value="OXR40450"/>
        <property type="gene ID" value="B7C42_07508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="6860" checksum="15A033F5A4A47C99" modified="2017-10-25" version="1">MALASLGTMTVPAIAAGCIGGAVAVGGLGAAIGGVGLAIPVGIAAGVQKYNQLQAQHAAETTGNTGVTVPSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV08</accession>
    <name>A0A231GV08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778551.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40436">
        <property type="protein sequence ID" value="OXR40436"/>
        <property type="gene ID" value="B7C42_07494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="40664" checksum="721E59F7429C0FF8" modified="2017-10-25" version="1">MNKLCRELGIEYPIFAFSHCRDVVAAVSRAGGMGVLGILAMSPDEIDVELRWLEEHSGGKPYGVDIVAPVSTADREAGLNDVGQVHSQLEDMIPAEHRQYAEEILQRYNVPQLPDTDGQQHGWATEGLTAAGGHDQIEVVLSHRNSLIVSALGPPPAWLVERAHESGTKIGALVGKPHQAVRNVDLGVDVIIAQSYEAAAHTGEIGSMVLTPDVVDAVGDVPVLAAGGIGSGRQMAAAMALGAQGVWTGSIWLACREAPAEQWQLDRLIEMNSTDTVRSKSQTGKFNRQIRTPWTEAWDDPKGPGALPMPLQYMLFADATARARRAGVHELVGGPVGQVVSRMTKVRPAAEIVLEMVEEYMDTLQRMSSQFEEITGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV27</accession>
    <name>A0A231GV27_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain type dehydrogenase/reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778555.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40432">
        <property type="protein sequence ID" value="OXR40432"/>
        <property type="gene ID" value="B7C42_07490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="30853" checksum="755B1FB6EB17516D" modified="2017-10-25" version="1">MAQLDFSDYVVIVTGAGRGIGRAHAELLADRGAAVVVNDTGGAVDGSLQGADPAGEVVEAITASGGRAVASTASVATEQGARAIVETAIASFGKLDAVVNNAGIYSVRSLHDITEAECRSFQDVHYFGSLFVSQAAWPHLAASKRGRIVNTISGAMLGVPDMVHYGAAKGAVFGLTRNLAVAGHADGIKVNAIAPGAGTRMVELATDALPPGMAAQMRESMPPRLVAPVAAYLAHERCTLSGEALSVAGGRVRRIAFGYTRGITDAELTPEIVADRLDEILHVGEFTPEPLMLPREAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC8</accession>
    <name>A0A231GVC8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid-associated protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybaB_5</name>
        <name evidence="2" type="ORF">B7C42_07444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40505">
        <property type="protein sequence ID" value="OXR40505"/>
        <property type="gene ID" value="B7C42_07444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15432" checksum="0A7123E59A8154A4" modified="2017-10-25" version="1">MSETPDLDATIEEMKTKTAQVKAELAKITGTGTAANGTIIATVDSAGHLRDLTLPRDTSRLGTQLAPLILQAAAEAEKDARRKSAAALQPFTSDDRVVSGLKAIGETLGPTASNPKPHRPMTEEEIQDADDAYFERMNRGGWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVT0</accession>
    <name>A0A231GVT0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40729">
        <property type="protein sequence ID" value="OXR40729"/>
        <property type="gene ID" value="B7C42_07153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025350">
        <property type="entry name" value="DUF4254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14063">
        <property type="entry name" value="DUF4254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15153" checksum="5A885E7176CECEC9" modified="2017-10-25" version="1">MVSTRLPGKNRVLQACRGIDYGDHLVLRLAHDLAELHERRLSAGSDVVVEIDRARANLVKGIDDWAAASLPPAIGAAYVHTETVGAIVDRLAQLTAHAFAALAGGPVADLGNAWERLAELAIGYEDLVEQVHTGHRRLPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVY6</accession>
    <name>A0A231GVY6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">smpB</name>
        <name evidence="4" type="ORF">B7C42_07077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40793">
        <property type="protein sequence ID" value="OXR40793"/>
        <property type="gene ID" value="B7C42_07077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="19831" checksum="672F991AA5616B3F" modified="2017-10-25" version="1">MTAWSAAELRGVEGKVYMKEKGRKVIATNRKARHNYTILDTFEAGIALVGTEVKSLREGKASLVDAYATIDDGEVWLRGLHIPEYGHGTWTNHAPRRTRKLLLHRREIDKLTGKTKESSQTLVPLSMYFTDGKVKVELALAKGKQDYDKRHDLARRTAEREVTRELGRRVKGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVZ5</accession>
    <name>A0A231GVZ5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40748">
        <property type="protein sequence ID" value="OXR40748"/>
        <property type="gene ID" value="B7C42_07172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1651" mass="179179" checksum="E46C7027F9E4615E" modified="2017-10-25" version="1">MPEPVRAALPDLVIDQIAQDLAEQIDHHSVGHCVRVDNLHLIDAERLARVLRNGAAGEHADVHVLIDTASRPESEELLIPAERAVELRNRKQRQLVLLVPVGVGGAASSLDNSFERQEAVELLRSASDTLVDALPDTDGIRTGTRRIARTLGPQRPVEAWARLVATISSDPRWDTLGSALPIVGLIPDRGGPELVDRLARNTECVTAISRPARAVSSVDDRLTNAKLQDGHVRTELAAFLNDPHRDLSNPMAWTADLASADLAFEHWPLAEPETVAVDHIRVDPFLRDNGAVLKASGLRQDSAGDLPYAEAGEDSPASLRVAWTTGPKKTDAIYRWRLEVVPPPDIRTGNDDHPFAKITVAGTRRSAKIAIELNEADLERGSLFVVRVTGLDTSGQPVLLQSGDEACDESQQFTIRWEADLITGETRRSSAWALALGRLDAVVGGQNNINEEAYSIDDQHSAISLRLGGRRTLLLGVSPVLVHLQRKLFSAELTATSFTAKGRMGVVLESTEIDGIKSNLPTALSKQRKEIHSALRCRQPRDLVEAVGWDSALREQVRAYCQAYKRALDQAASDSAHRDALLAMDTLTLDITTAAGKPIRAVVVLPFHPLRLTWLAEYDHALSRWAGELANSGFDASRRRSLVDIDLVRRVTPANLPFAVPGPTAGDIYVHAREATVGTGIYLAADELEPGIAIQAVFDVLGIHSDDAATDVPAGLVTEHLDTYLKAQSYPEALRLLTINPGSGELLAAALKHVMLTGQETDIDGATSRLQRRVEVVSYGTRMSDTDPLPALTDLQRSVSKFRVGKGRSYLRPPLGLSVRPFDRLAHDDVPAHLCVLSNLTAMAAGGASVQSDSTTSFRNLLTPTSNRKVETEDGSFYWESAPAVRLRDSKDGRNKDGAADAVDAHRAHQIALAAAAGLPAEHGIALRVELSEAQTSALAAAHDCADWVLSIDRNVGLERLLPQGDHTGESNHPYILDYAPDFLEGIGPRLTVTTKHQEEIALQLSAALEALRLTTGTEHVSSALHYVQLVSGRLALRLTEDRRAAMDAAALTAYLARLSDRGDLDDTIVVPVDLHREMFSVPRAETRLCDIMLIRVTRQSIRMQCVTVLPRLRQTPIDQLADEISERLENTMRVLENCFLGVDQPRLDIDLQRARLAGILRHHAKRASGMGLLSEERLATAERQFARIEDGINPEISKYGCIVGVDPEEDFAREYRGVQIEMLAPAKGVAASAPSPSFEPPPKQPFSAPPTQQAVAPNSREAGSSSEAPEAENPGPPPEATIITPDGDSDVDAIEAINEQHAVPEPTNPDSIAVTLGVDGTGAGVNWRISTSGSPHMFILGIPGQGKSVTTRRILNSFAAQGLPALVLDFHGDMAADPAASAIVVDAADGLDFSPFELRDDLDHRKYAQNAWELAEVIGYVSGLGEIQRNVVYDTLVELYERYGFGSTNGPEGLPTMPQFARLAAQKESAGNGRNVAARIRPLSDFGLFKNQHGATNFGDMLRRGVVLDLHTLMEQVQLAASAFVLRKVYREMFRWGKTDSLRLALILDEAHRMAKDVTLPKIMKEGRKYGVAVVVASQGVDDFHRDVLGTAGTKVAFRCNFPQSKTVAGFLRGRSGTDMAMALEKLSVGQAYVSTPDSPEARKVFMANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW84</accession>
    <name>A0A231GW84_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40835">
        <property type="protein sequence ID" value="OXR40835"/>
        <property type="gene ID" value="B7C42_07119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="21633" checksum="CBFCADBFE6AD9DAF" modified="2017-10-25" version="1">MAGVTLWMQMSLDGYAEGPDQEIHWPVVDEELCESFLDELRAAEVFVYGRKTFEIMAAFWPYADADPAISPFYVEFARCWKRTPKLVFSHTMRDPGWNTRVIGADPIAEISALRTASAGPVVVFGGAQTASYFLEHDLVDEYRLFVHPLLLGGGVPLFPKPLDTAGLQLVDIMTFDSAVVQMHYQQATPVARMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWM1</accession>
    <name>A0A231GWM1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysine/ornithine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ldc_2</name>
        <name evidence="4" type="ORF">B7C42_06965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40999">
        <property type="protein sequence ID" value="OXR40999"/>
        <property type="gene ID" value="B7C42_06965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="PTHR11482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="208"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="34759" checksum="82618C8D3814A4B6" modified="2017-10-25" version="1">MPEIIRLLDSEGAEFDVASIGEIEMCVALGVDPAALCYGNPIKKAAHIAAAYAAGVRRFAFDTEDDLERIAELAPGSEVECRFLASAPQSQTPFGTKFGCAPGEAVRLLVRARDLGLQVAGPYFHVGSQQLDPVAWQIGIEQAAAITEALAVKDIPVASVNIGGGLPISYADPAPELSDLGVVIAAAAARHLPEHTDLVVEPGRALVGNAGVIHAEVVNVRIAPDGRRWVYLDIGRYNGMAETENEYIAYRIATDRDGDPADEAVIAGPTCDGDDVLYQRTRVLLPTTLRAGDPVRILDTGAYTASYSSVSFNGFPPLTVHVIGAERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX08</accession>
    <name>A0A231GX08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EPTC-inducible aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcA</name>
        <name evidence="3" type="ORF">B7C42_06882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41112">
        <property type="protein sequence ID" value="OXR41112"/>
        <property type="gene ID" value="B7C42_06882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20106" checksum="EEFF2D23D23CC9F9" modified="2017-10-25" version="1">MEANLTAIAVAETWDNGKPIRETLAADIPLAIDHWRYFAGVPRRAVFGIDKHTVAYHFHEPLGVVGQIIPWNFPLLMAVWKLAPALAAGNCVVLKPAEQTPWSVLKLVELIGDLLPAGVVNAVNGFGVEAGKPLASSPRVAKVAFTAETTTGRLIMQYASEKIIPATLELGGQEPEHFLRIRCVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXL2</accession>
    <name>A0A231GXL2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase complex repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdhR_2</name>
        <name evidence="5" type="ORF">B7C42_06710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41312">
        <property type="protein sequence ID" value="OXR41312"/>
        <property type="gene ID" value="B7C42_06710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="27852" checksum="B8DE76935E6AB423" modified="2017-10-25" version="1">MPESPSSSTVARHPVQLQPMQVPKASDVLANDLRERILRGEFPSGTALPPERELVTQTQMSRTTVREALRILEVQGLVVIKTGRSGGAFVQQPGGASVASSVSLLIRGQQLRLSDLLETREAIEPACAGLAAKYRTDDDIAALDAANAKLGDLDIPLEEFLQANVDWHLAVAAASHNELLTGFMTALSNAIYSSTENTAFVDDEVRKTTHRAHKTITDAIRAGDPAVATRRMSKHVHGYAEAVVQVEERTEIELREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXU7</accession>
    <name>A0A231GXU7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-threonine aldolase</fullName>
            <ecNumber evidence="2">4.1.2.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.42" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41395">
        <property type="protein sequence ID" value="OXR41395"/>
        <property type="gene ID" value="B7C42_06538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043876">
        <property type="term" value="F:D-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="393" mass="41408" checksum="ADE9A1C6D0A54A2A" modified="2017-10-25" version="1">MVTHASPIADLHAATADLDPPLAALDLSALRANAADLVRRARGVPIRVASKSVRCRAVLEEVLGPQLTGRGGFAGIMSYSLREALWLAGHGARDILLGYPSVDRAALADLGADATLLDSITLMVDDVAQLDLIRAAVGGAGISPRVCLDVDASLRVGPLHLGVRRSPIRTPEQAERLARVARERGFRVVGVMTYEAQIAGLPDTNPAVRLVKRLSAAEIGTRRTQVLEAVRAVAGELEIVNSGGSGSIEVSVAAPEVTEVTAGSGLYVPTLFDGYRAFTPRPALYFALPVLRRPAADIATVFAGGYIASGPAGASRVPKPVWPKGLRLIGTEGAGEVQTPFTGAAELAVGDRVWMRHAKAGELCERFDAIHVVDADDRRTTVPTYRGEGRNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXY8</accession>
    <name>A0A231GXY8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fadB_4</name>
        <name evidence="1" type="ORF">B7C42_06534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41391">
        <property type="protein sequence ID" value="OXR41391"/>
        <property type="gene ID" value="B7C42_06534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="27730" checksum="B29B8A1B712D19A0" modified="2017-10-25" version="1">MSDSKPTRLERTETEAGAQLAIITIDHPPLNLFDSALLGSLAADLAELTANPPRALLIRAEGKVVSGGVDVHEFDGLSVDQGAELWQRLFRSIIHPVEALPCPVVFAAHGLTLTAAFEISLACDILLAGPKAKFGLVETVVGLTPSMGGPQRLAERAGSGRARELVMTGDLYDAATLADWGVVNAVHEDVDAAARALAARLADGPTRAHAATKQIIEAWRSGGVEHADSVTPKVSGELFDTEDLRGAVRSFLEVGPGKASYTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXZ8</accession>
    <name>A0A231GXZ8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">manA</name>
        <name evidence="7" type="ORF">B7C42_06585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41442">
        <property type="protein sequence ID" value="OXR41442"/>
        <property type="gene ID" value="B7C42_06585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="411" mass="44292" checksum="13E03A9FE7B21880" modified="2017-10-25" version="1">MHELVGALRSYAWGSRTALAQLCGREVPSPHPEAELWFGAHPADPAKVLADGAGRSLLELLEAEPNRELGTVASAFGGRLPFLLKILAAEEPLSLQAHPSADQARYGFERENHTRVPLDSPMRNYRDDSHKPELVVALDRFEALAGFRDPLRTVDLLNSLAVPELVQYTELLAAQPDSGGLRALFTTWITLPQAMLATLLPKVLDGCVRYLKQVDPLESPRQAKEFAAEARTTLELAEAYPGDAGVLAALLLNRLTLEPGQGLFLAAGSLHAYLRGMGVEIMANSDNVLRGGLTPKHVDVPELLRVLDFEPLRTPIIDPEPVDENSFRYPTPAAEFALRRFELTEDAAAVDIPRVGPGIMLVTAGTVVLSQAGNELPIAAGSAAWISATDTDIRARALGGPAQLFCACVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY55</accession>
    <name>A0A231GY55_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mycofactocin system heme/flavin oxidoreductase MftD</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mftD</name>
        <name evidence="7" type="ORF">B7C42_06440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41547">
        <property type="protein sequence ID" value="OXR41547"/>
        <property type="gene ID" value="B7C42_06440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023989">
        <property type="entry name" value="MftD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03966">
        <property type="entry name" value="actino_HemFlav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="311"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="334"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="41541" checksum="6B320BD3770EAA9A" modified="2017-10-25" version="1">MASTRDWFESVAEAQRRAKKRVPKAVYLALLAGSEAGATLDDNAAAFTELGLRPHIADLPATRDLATTVLGQDISMPVICSPTGVQAVDPAGEVGVARGAAMSGTALGLSSFGSKPIEEVIAANDKTFFQIYWLGSKDDMVARLDRAREAGAKGIIVTLDWVFATARDWGSPALPERVDLKTAVRFAPQVVTKPGWLWRFARTGKLPDLTTPNLVPRGQQGPTFFGAYGEWMGTPPVTWDDLAWLRQQWDGPFLIKGIGRPDDAKRAVDIGATALSVSNHGGNNLDTTPATIRMLPSVVQAVGGQVEILLDGGVRRGSDVVKALALGANAVMIGRPYLWGMAAAGERGVHNVLEVIRQGIDSALYGLGHSSIHDLSPEDVIVPDGFTRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYQ2</accession>
    <name>A0A231GYQ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41720">
        <property type="protein sequence ID" value="OXR41720"/>
        <property type="gene ID" value="B7C42_06062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="22557" checksum="2C97A57547556AC9" modified="2017-10-25" version="1">MGVGIVGRIRRRSGARYGIEESFTARAQHAGGPRLRCRGSVRLRRRRGERRARSVCGRGDSRARPCGPRSHAPRSRCGTLVRRRPCGAVYSDPDPGSDPECGTVRVARRRRLSGAGQRPGRFGQLAHEAAGAPDHGELVTRRRGGMAGHRSGRLGRVAGVGVGGQHSASRRNSRVRDRDGDRRARRSGHPGRSSRLQPHPSGVARPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYR4</accession>
    <name>A0A231GYR4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Murein DD-endopeptidase MepM</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mepM_2</name>
        <name evidence="3" type="ORF">B7C42_06080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41738">
        <property type="protein sequence ID" value="OXR41738"/>
        <property type="gene ID" value="B7C42_06080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="333"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="444" mass="46478" checksum="44DDCAE37FE0EE2C" modified="2017-10-25" version="1">MSHGRLQPGHRPQSARRYRGDGESLDQHPYFDGNQSFGGYTGSRSEEPAAPSVRSMPGRADSWMSAGPGAAGATVVGLTATTGNSTENAWGATGSEESGGWQPWGAQAQPGGDWTADPQWPRTDEWAAADPGFDDGRGVHFPEGPADHDAAHYDADHYDAADEYDEPAGNEPFTPSPLRSSWKRESADADEAGTDAEAPRRFSGAHRVPTPPAALKGRAAVVAVAAGAVVAAGQAGMESGSQHHTATADYDAAGQVHEIAAQAVSTQAGNPQSPQVLNVAPVADLRQFQDILQHGQEFAAGLAAQESAKLRPLFSKFANGTFTSGFGSRWGVQHLGVDIAAPIGTPIYAVEDGEVISAGPASGFGMWVRLRHADGTITVYGHVDTATVSEGQHVLAGDQIATVGNRGFSTGPHCHFEVWLNGQDKIDPLPWLASRGISLGPERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYZ2</accession>
    <name>A0A231GYZ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41829">
        <property type="protein sequence ID" value="OXR41829"/>
        <property type="gene ID" value="B7C42_06171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="19705" checksum="62FAAFCE8F1B6A59" modified="2017-10-25" version="1">MTRPNHHVHSPARPDIEPAARVQFKDYETKTGYVDGAWWPRSPDLATELPGLLAAVSPALGSIHRVVYNAAEWNPVAGFEAVRLDGTRHGTAHTVEVLGARDRRRVLLIIPPRTDTHRACAVMALACRANDESTVDELLAQLPGRTGRAAALRRWRNGATGRESAVAGRIHPTIERHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ34</accession>
    <name>A0A231GZ34_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_24</name>
        <name evidence="9" type="ORF">B7C42_05858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779078.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41874">
        <property type="protein sequence ID" value="OXR41874"/>
        <property type="gene ID" value="B7C42_05858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="383" mass="42322" checksum="115CD7EDCB82AB41" modified="2017-10-25" version="1">MKTDLFESDHELFGRTVRGFVERHVIHKMEKWDADRLIDRDTWRAAGQQGLLGLAVPEQYGGAGETDYRFRVVIQTEIARVGASALQSGFSTNDDIVLNYLLRHANSEQRDRWLPGFTTGETIGAIAMTEPGAGSDLRSVQTTAVREGEEWVINGSKTFITSGMLADLVIVFAVTDRDLGSRGFSLFVVEDGTPGFTRGRKLDKVGLHAQDTAELFFDNVRVPDANRLGDIGGGFGYLMQSLPLERLGIGIAAQVSAEAVLGWTLDYVKERRAFGKPIGEFQGLGFTLAELQTATEVSRAYIDRCVREYNRGTLTAVDAAKAKLWATELQGKVIDAGVQLHGGYGYMMEYPVAKAFIDARIQRIYGGTNEIMKEIIHRDLMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ35</accession>
    <name>A0A231GZ35_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41832">
        <property type="protein sequence ID" value="OXR41832"/>
        <property type="gene ID" value="B7C42_06174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="33309" checksum="E7586326B25D25BF" modified="2017-10-25" version="1">MSKHSAAIVASAVSAASSIMLAARRPAVFGLRLPRAALAAVAAIALAIAANESVGKPVMFLRWSYVRFLFGLRHMGATWQVGDGREQALADYVCAHARRNDIDDVIRAIDEFCYTKSYLINIGDEKGRILDRAVAAAQPRRLLELGTYCGYSALRMARVMPADAVLYSIEFNAANAAVARRIWDHAGVGDRIVVIVGTLGDDGKTLGALAGEHEFSPGTLDFAFLDHEKDEYLPDLHRILDQAWLRPGAVVVADNVKYPGAPEYRAFMRRHEGTRWTTREHRTHAEYQKVLKDLVLESTYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZD2</accession>
    <name>A0A231GZD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aliphatic sulfonates transport permease protein SsuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ssuC_4</name>
        <name evidence="7" type="ORF">B7C42_05951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41967">
        <property type="protein sequence ID" value="OXR41967"/>
        <property type="gene ID" value="B7C42_05951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="29555" checksum="6A76B0C87A97342D" modified="2017-10-25" version="1">MTSSLRTTPDTAGPPAPASPRRDRIRLARLPRHWRTVGGTAAGLVLAALVWSLVAASGSFPRQLFPTVPQIARAGQALCSDGLLLPDIAASLQRALFGLVVGVAAGVLAAIATSTTRVGRAVLQPVLRLLSPIPTIGLVPLAILWFGLGENSKVLVIALGVFVPVWINSHSGFAGTPEHYLQAARCLGASRWHTLTRIVLPEATPDVVGGIRVGAAMAFVLIVVAEMTGTTAGIGYRIYQAQLFSQADRLIFCLIVLGVLGAACDLAIAAVTAPVVRWAKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H074</accession>
    <name>A0A231H074_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42254">
        <property type="protein sequence ID" value="OXR42254"/>
        <property type="gene ID" value="B7C42_05853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="42816" checksum="57271F1DEC4C2D9B" modified="2017-10-25" version="1">MPFRADPVVPADIAPALYDALPVAEDEVFETVARELPVFAEVFEGALGGRARADINTMLAGFLVLACGDGPGRRPVDLVAVERAAYDLGRFEAYSGRSIDALNAAFRLGARIGWRHWSGTAQTHGMSTSGIARLAELNFDYIDNLADAAVSGHAAELISAGQQRQRRRERLTEHLLTGAADDEIRAAAELAAWHAPETMVAVVLPRSDARNAVPLVDHRTLQADDDLVPGPAGSGLAVLLVPISATTSRTTLVRRLADLRAAVGPEQPWLDVRYSAVLATRAWECHTDGPWPLDAEKSLAQLVVHADPRTRQLQRAAALAAFDHLRPDTRERYEQTLRAWLLHQGRREDVARHLILHPQTVRYRMDRIREILGDDLNDPERVLDLVIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H092</accession>
    <name>A0A231H092_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42294">
        <property type="protein sequence ID" value="OXR42294"/>
        <property type="gene ID" value="B7C42_05493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="90" mass="10049" checksum="C11E31656E3F9FFA" modified="2017-10-25" version="1">MSDVAELEKLSSKELHDRAVKHAVRHGDVKFLWRLLEQIPAAEAATGNIGGSEADIKYVLPMLDDYVHSGEGKIAEALRPLYIEYLSTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0I1</accession>
    <name>A0A231H0I1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782097.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42359">
        <property type="protein sequence ID" value="OXR42359"/>
        <property type="gene ID" value="B7C42_05558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="31898" checksum="A96D631F25826F7E" modified="2017-10-25" version="1">MDDNTPTPEGDATRPDRQLIQRREQAWSNYQQACADLAGTRIRANLDGWKRWLRVLPGAAVDQAERRRDEIRAELARHCVGADARVWGVLSGGDTGTFGGCFGLEHTIGQLADLYDRTDSHWVRALRETARRTTDIRPLAADGDRSAVSDLTERVVQAVRMAPDDEARRRLTVHLPGEVRPVPADPATLAQKQGPAAVQFDIYASTIKLDHIDVIPPLRRMGLGTATLRHLCRTADAHGMHIVAQLVPTFRDDDSAVPILARWFREQGFEVTERLGGRVVRAPASIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0U4</accession>
    <name>A0A231H0U4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nitrate reductase-like protein NarX</fullName>
            <ecNumber evidence="15">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">narX_3</name>
        <name evidence="15" type="ORF">B7C42_05255</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="15"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42479">
        <property type="protein sequence ID" value="OXR42479"/>
        <property type="gene ID" value="B7C42_05255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="8"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR42479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="27111" checksum="BF2275C6A5BA0A89" modified="2017-10-25" version="1">MTVSAIDVLLWVAVPYAATAICVVGLIWRYRYDKFGWTTRSSQLYENRLLRLGSPLFHYGIVFVFLGHVLGLVIPQSWTEAIGISESAYHIVAFSLGAVAGIATVAGLGILIYRRRTVGSVFSATTRNDKIMYVLLGLTLALGLAATVYGNATGDPHNYRTDVSPWFRSLFYLDPHPELMAGAPLGFRLHALSACALFAFWPFSRLVHVFSAPVGYLTRPYLVYRSRDVSLGAHRPPRGWERVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0W9</accession>
    <name>A0A231H0W9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nuoN</name>
        <name evidence="8" type="ORF">B7C42_05264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778091.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42488">
        <property type="protein sequence ID" value="OXR42488"/>
        <property type="gene ID" value="B7C42_05264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="181"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="541" mass="55603" checksum="1FB0394ED48D392B" modified="2017-10-25" version="1">MNQYLAATVPAPSIEYHALSPMLVVFGVAVAGVLAEAFLPRSWRYPVHLVLALGGLVAALVAVIALAGTHATVAVGAVAVDNVTLMLQGTILVVAILAVALMAERGIEPRLARESREGPGTWSRAAALASGAVVVDAFTPQAAAVPGSSDEIAAARAGITTTEVFPLTLFAVGGMLLFPASNDLLSMFVALEVLSLPLYLLCGLARRRRLLSQEAALKYFLLGAFASAFFLYGMALLYGYAGTVRLSGIADAVARDSGSKTLAVLGVAMLVVGLLFKIGAVPFQSWVPDVYQGAPTAVTAFMAAATKIAAVGALLRILQVAVPGLSADWRPILGAVAVATMVLGAVLAVTQTDVKRMLAYSSIAHAGFILTALVAANSDGVSSVLFYLAVYGVSTVGAFAVVTLVRDRVGDEATALSAWAGLGRRSPWLATVFALFLLSFAGIPLTSGFVGKFAVFSAAAAGHAAYLVIVGVISSAIAVFFYIRVIVQMFFTDPPEAPPAVVTAPVTTMVVIVTGAATLALGIVPQPLLDLANRAVGFVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1H3</accession>
    <name>A0A231H1H3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_05028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42692">
        <property type="protein sequence ID" value="OXR42692"/>
        <property type="gene ID" value="B7C42_05028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="706" mass="74996" checksum="99F6D5DC4381589E" modified="2017-10-25" version="1">MPELPPVPTLLATAVEALGGTARTGQQTMSAAVAHSIDTKEHLAVQAGTGTGKSLAYLVPSLRHAVQSGRTVVVSTATIALQRQLVDRDLPRLAQALEKPLGRRARFAILKGRNNYLCLHKINSAIPDEPPETELFDAFAISRLGREVQRLNDWASDTETGDRDELVPGVSDRAWRQVSVSARECLGKSRCPFGTDCFAERARAESGQADVVVTNHALLAIDAISGIQVLPEHDVVVIDEAHELVDRVTGVATAELSTATITAAAKRCTKLVDEGDLDRLEGAAEAWHELLEDLPPGRWDELPAGGDQVLALLRDAAWTVRTALAPPGSGAPQGDPEAAAARNMAVAAVEEVHDTAVRALTAFEEPDPAARRDVLWLAVDEVRGVARRTLHMAPLSVGGLLRSRLFGTATVVLTSATLQVGGSFDGLAVTWGLPPQAPDRAGTDVPGAERADQGSRRIDPAMANGAEAPADTSAMRWNSLDVGSPFDHAKSGILYVAKHLPPPGRDGLAPAYLDEIERLIEAAGGRTLGLFSSMRAAKAASEILRERLDTPILCQGEDATGTLVRRFAEDPATSLFGTLSLWQGVDVPGPSLSLVILDRIPFPRPDDPLLVARQQAVQARGGNGFLTIAANHAALLLAQGTGRLLRSVHDRGVVAILDPRLVTARYGGYLRASLPPYWETSDPEVVAKALRRLTATAPDPAVAAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1I2</accession>
    <name>A0A231H1I2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42710">
        <property type="protein sequence ID" value="OXR42710"/>
        <property type="gene ID" value="B7C42_05047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="24806" checksum="0ECA8807DD9F2EF5" modified="2017-10-25" version="1">MPKKRKVANLLALAVLATLIERPMHRYEIAAQMRERGKDRDMDIKWGSLYTVVQNLEKHGFVEVIGSERDGARPERTIYRLTDAGRAEAEDWIRELISTPEPEPHRFVAGLSVVALLPPDEVIPLLDERARLLAAEIAVRRREIEEQTQFLPRLFLVEAEFGVAMLEAEAAWVAGLRTELASGTFPDIDFWRRAHSEQIPPAEIAAMVEGGTFRQPTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H207</accession>
    <name>A0A231H207_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42878">
        <property type="protein sequence ID" value="OXR42878"/>
        <property type="gene ID" value="B7C42_05216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="37098" checksum="1D1E906F9379EDFA" modified="2017-10-25" version="1">MTTTREAAAAIREVRRPEDLFGAATTGSAARRSAHRTYLRLAVALHPDRVPVAEAERATAAFVHLGELYRSWLAAGQAFEVCGGRERYRLGAIHARGSVADVYRTDSAAVVKIARRPAANSLLANERNALTDIAALTGEHEWLAPYFPRLIDTVDHTDTDSGEVRAINVLDALTDGFVTLAQVHAAFPRGLDPRDYAWMHRRLLRCLAGAATAHWVHTAVSAENVLIHPRLHGVVLVGWSFATRPGRVPAATPASIDYPPEIGTGVCPRTDVYLAHRLLLTMLGDRAPAPMRAFAEGCLQSAPRLRPDARTLLDEFDDLLDRLYGARRFRPFELPKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H212</accession>
    <name>A0A231H212_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon_2</name>
        <name evidence="5" type="ORF">B7C42_05223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780155.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42885">
        <property type="protein sequence ID" value="OXR42885"/>
        <property type="gene ID" value="B7C42_05223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011291947" description="Endopeptidase La" evidence="2">
        <location>
            <begin position="37"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="4">
        <location>
            <begin position="236"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="35766" checksum="036A4DA790932090" modified="2017-10-25" version="1">MGRVNRRIITLIAALVPVLVLGVVGSAVTVPFVALGPGPTFNTLGEVEGKQVVAVQGAAVDPTSGHLNMTTVSVRDGLNIFEAMGLWVDGRYGLVPRAEVYPPGVPRDQVDKSNQADFKESEDNAELAALNFLKYPTKVQVRVVADDGPAKAVLQKGDELVSVNGKPITTSKDVIDAVQGAAPGTTIPMVIRRGGVEQTVEVKLGARPDDSNKAYLGVTPQEVPDGPLQVDFNLADIGGPSAGLMFSLALVDKLSPGELNGGRFVAGTGTIDPQGKVGPIGGIQYKMIAARDAGAETFLVPADNCNEARQRTPDGLKLVKVDTLSSAVQSLDDVNAGRPAPSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2C5</accession>
    <name>A0A231H2C5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42999">
        <property type="protein sequence ID" value="OXR42999"/>
        <property type="gene ID" value="B7C42_04885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="19340" checksum="210455B4146F6294" modified="2017-10-25" version="1">MTEPRWLDDLETRAWLGFVFTRDLIAAAVGRDSLRASNLTYVEYTVLARLADATDHRRSFAELASVLEWSQSRLSHQITRMEKRGLVAREAIPDDARRTAAVLTPKGAEVLATAAPAHVESVRRHMIDVLDRDQLAALADIYDTLLTHHRAPDPGGEACIDHSGAVPREPSPQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2F8</accession>
    <name>A0A231H2F8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoid occlusion factor SlmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">slmA_3</name>
        <name evidence="5" type="ORF">B7C42_04919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43033">
        <property type="protein sequence ID" value="OXR43033"/>
        <property type="gene ID" value="B7C42_04919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="2"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="180" mass="19679" checksum="B0F56B4E6E9B9D04" modified="2017-10-25" version="1">MTIAQVAAEAGYARTAVYAVFPDLPALIDALAERHMNAIIAAADQLLAQPLPARQLLRAVVTLMCDFVDANPNLHHVMMQRLERGDAEHRPFFTRVSDWATSIFDIILRRLDADPALARIWATATVGAILMSAEAWIQQPTRSRAEFVDQLAAFLWPSVESIGGDRLVGPLVGAAEPVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2P7</accession>
    <name>A0A231H2P7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid-associated protein Lsr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lsr2_3</name>
        <name evidence="2" type="ORF">B7C42_05000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43114">
        <property type="protein sequence ID" value="OXR43114"/>
        <property type="gene ID" value="B7C42_05000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="16592" checksum="348D7C29313547B3" modified="2017-10-25" version="1">MFPPDQAWGFVLLLWLGLAFRRVRCWLIEGCFMAKKVIVELVDDYDGKSKADETVRFGIDGVEYEIDLSLKNAGKLRAAFEPWTEPARRVGRIPRGKSKTIETRTNADKHQTAAIRDWARDNGYEVSRRGRIHKDIVEAYNKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Q5</accession>
    <name>A0A231H2Q5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropinesterase</fullName>
            <ecNumber evidence="3">3.1.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43107">
        <property type="protein sequence ID" value="OXR43107"/>
        <property type="gene ID" value="B7C42_04993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050357">
        <property type="term" value="F:tropinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="33117" checksum="680E228515482373" modified="2017-10-25" version="1">MAAERQTAGNGRGAAGGRFGTRVSRTNSVPAGRMVDLPGRGRTYLVDIPGPEGAPTVILLHGLVTTAMLNWFPALAELSEHYRVVLFDQRWHGHGIRSPRFDLNDLADDVVAVSEVTGVQRPILAGYSMGGIVAQSVAHRRPDLVGGLVLCATTYRFREKWRERLFHGGMALLAGVMTETAGRRVAEAATKLPIMPEISWETGRMDRWALAELRTTSGWAMTQAIAELGRFDSSPWLPSLDVPTGVVITTHDRALPVYRQLEMAKMIAGAEIFLVPAGHAACVLEADAFVPVLLEACAAVAARRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Q6</accession>
    <name>A0A231H2Q6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43124">
        <property type="protein sequence ID" value="OXR43124"/>
        <property type="gene ID" value="B7C42_05010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="29655" checksum="6AFBD379D26E8C1A" modified="2017-10-25" version="1">MSHFHDGVIYRTVGIDFSEDSKTIEFSRGYYFEHLDTNEVLAYSAVARTNRRYRARLKDPFDLRNRVAGLGILTLTVYEKKPGEFAFLMHKRSDKVVIGAGMFHPVPAGEFTPSDVSLESFERDFDLRRNIDREFAEELLGDPDAQGAGGFQIDYVNARPYKELRESMKAGDLSYHCLGIGMDPFTWKLELLTIAIFRSDSFQWVFGDGKLPGNLEGTIIQDNRFNEKVIDQYVHSGSIRLGAVTTLRLAWMHRGLLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3D6</accession>
    <name>A0A231H3D6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prpC</name>
        <name evidence="8" type="ORF">B7C42_04247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43380">
        <property type="protein sequence ID" value="OXR43380"/>
        <property type="gene ID" value="B7C42_04247"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="374" mass="40867" checksum="40B1658657E07BB5" modified="2017-10-25" version="1">MTKAATPAINKGLAGVVVDTTAISKVVPETNSLTYRGYAVQDLAAHCTFEQVAYLLWYGELPNDAQLERFCQQERAARRADRSLLSLVTKLPDTCHPMDVVRTAISYLGAEDPLEDDNSPKANRAKALRMLAVLPTIVAADHRRRHGLDPIAPHSHLGYAQNFLNMCFGTVPAPELVRAFEVSLILYAEHSFNASTFAARVVTSTQSDIYSAVTAAIGALKGPLHGGANEAVMRDMLEIGEPERAEAWLRKKLADKQKVMGFGHRVYKNGDSRVPTMKRALLDIAAATGGGRWVRMYEILEHTMSEATGIAPNLDFPTGPAYYLLGFDIETFTPIFVMSRITGWAAHIIEQGASNALIRPLSEYVGVGQRSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3J5</accession>
    <name>A0A231H3J5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43415">
        <property type="protein sequence ID" value="OXR43415"/>
        <property type="gene ID" value="B7C42_04282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="354" mass="37904" checksum="DA1F3F00B37DF419" modified="2017-10-25" version="1">MRIAITGASGNVGTPLLRALPDAEIVAIARRPPPADREPYSRARWVACDIGDPAARPTLAAAFAGTDAVVHLAWAVHPRRTDPPLERTNRIGTDHVLGAVADSGVTHLTVASSVAAYSPAPRWTRVDERQPRGGVPGGAYSRDKADLERRLDAFAAERPAVGVARIRPCGIAQSDAAAELGDWLLGPWLPRSPVGRPWLPVPLWPRLRLQLVHAEDVAAAIRAILVRRATGAFDLAAEPVLTAPLLTEIFGGVRIPVPRPLLAAAAFAGWRAGLLPLHPAWLGLADRACLVRAERARRELDWRPAHSAVDVAAELAAGLREHASGGSPPLNPDPMRCRPGRPTHQDQRPDHRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H430</accession>
    <name>A0A231H430_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hca operon transcriptional activator HcaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hcaR_4</name>
        <name evidence="3" type="ORF">B7C42_04483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778913.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43615">
        <property type="protein sequence ID" value="OXR43615"/>
        <property type="gene ID" value="B7C42_04483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="31316" checksum="F6B30F045763165B" modified="2017-10-25" version="1">MELELRHLRAFLVLCEEANYTRAAARLHTTQPSLTRTVQQAERILDCRLVERSARRFALTAEGEYLLAAATRIVADADAVTADLRLRARVSVGFSWLLPDDWFTEVRTRFEARGGRVGIHRIDDPVAAVAAGRIDIALYRKEIRLPSAMTGRIIGTERRVAAVSTRSPLANTPALRWQDLAAHPLVVNTISGTTDETSWPAAESGREIVTCTNFDEWIELIAADRGVGAVPELARTRAPHPGVAYLDVPDAPPSTLRLAWRTRPAPGRSVRSFLDIAVSGQGAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H498</accession>
    <name>A0A231H498_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(S)-1-Phenylethanol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.311</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ped_2</name>
        <name evidence="1" type="ORF">B7C42_04526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.311" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43658">
        <property type="protein sequence ID" value="OXR43658"/>
        <property type="gene ID" value="B7C42_04526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="25962" checksum="ED0EA967CC9D48F6" modified="2017-10-25" version="1">MISHEGRVAVVTGAARGIGQAICRRLAAEGAVVVAVDITAPTETLAEIHRHGGTATANVVDVSDPTGTQSIGAEVQERYGRCDILVNNAGIYPFIDIDDLDYDTWRKVLAVNLDSQFLMTKTLLPLMKSGQWGRIVNLTSNSIGLAVPGLTHYMASKMGTIGFTRALANDVAAQGITVNAVGPTLSRTPGVTSAVDSALQEQVAQSQAIKKVGEADDVVGTVMFLTSEDSYFVTGQTIMADGGLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4D7</accession>
    <name>A0A231H4D7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-hydroxymuconate semialdehyde hydrolase</fullName>
            <ecNumber evidence="3">3.7.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xylF_1</name>
        <name evidence="3" type="ORF">B7C42_04520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43652">
        <property type="protein sequence ID" value="OXR43652"/>
        <property type="gene ID" value="B7C42_04520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018775">
        <property type="term" value="F:2-hydroxymuconate-semialdehyde hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="31311" checksum="463358312C10EEA6" modified="2017-10-25" version="1">MPTSDVIDSTQAPSPSPEIGKTIDVAGVATNYHDLGTGDPVLLIHGSGPGVSAWANWRLTIPALAQRHRVIAPDILGFGYTQRPGGAAYNAETWLEHLGGLLDALGLDRVSVVGNSFGGALALRLATRFPHRVHRLVLMGSVGVLFPITPGLDAVWGYEPSVPAMRHLLGVFAYDPKYATDELAELRYRASVRPGVHESYAAMFPEPRQHKVAEMAVSEHEIAELQHQTLIVHGRDDQVIPLSNSHRLLDLIPNSQLHAFARCGHWVQIEHTERFNTLVDSFLSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4H8</accession>
    <name>A0A231H4H8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN reductase (NADH) RutF</fullName>
            <ecNumber evidence="4">1.5.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rutF</name>
        <name evidence="4" type="ORF">B7C42_04484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.42" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778912.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43616">
        <property type="protein sequence ID" value="OXR43616"/>
        <property type="gene ID" value="B7C42_04484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="3">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17379" checksum="C5DF04147A9188C2" modified="2017-10-25" version="1">MDAIANFDALVAAADAPIYVVTVATESERAGCVVGFASQVGIEPRRFLVCVSELNHTYRVVAGATHVAVHLVDSGSRALAQLFGAETGDDIDKFTWCRWHHGPDGVVVLDEAAAWFSGRILERHDFGDHMGLLLEPLGGPKPTEGTTGLRYSDLADLTPGHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4P5</accession>
    <name>A0A231H4P5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ECF RNA polymerase sigma factor SigI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sigI_3</name>
        <name evidence="7" type="ORF">B7C42_04042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43807">
        <property type="protein sequence ID" value="OXR43807"/>
        <property type="gene ID" value="B7C42_04042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="416" mass="45469" checksum="B31D0F2A73C47FD7" modified="2017-10-25" version="1">MELRESVEALWRIEAPQLIATLARRIGDLDIAEDLVSEAFVAALEQWPAEGVPARPGAWLMSTAWHKAIDRARREETARKKAPLLLAGRDGQLPDVTAEALTPIPDDLLTMVFTTCHPVLSPESRVALTLRLFGGLTTEEVARAFLCPSATIGQRISRAKRTLAEARVPVVAPSAGELPERLRAVLEVLYLIFNEGYSASSGENIVRTDLATEAMRMGRVLAGLLPTEPEVFGLAALMELQASRFRTRVDENGIPVQLEHQDRHRWDRTLIEHGLGMLDRAFDLARPLGPYSLQAAISACHARATTFGETDWVAILALYDALAQLTASPVVEMNRAVAVLHVDGPEAALAATEPLLADRRMARYHLLGAVRGDFLTRLGRHHDAAAELERAAELAPTRQERQLLLDRMAAALAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H565</accession>
    <name>A0A231H565_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 6">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folA</name>
        <name evidence="9" type="ORF">B7C42_04216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43977">
        <property type="protein sequence ID" value="OXR43977"/>
        <property type="gene ID" value="B7C42_04216"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="18387" checksum="E8A3DE85AFC532FA" modified="2017-10-25" version="1">MSRIGLIWAQTPAGVIGADNAIPWRVPEDMAHFKTVTADHPVLMGRRTWDSLPARFRPLPGRRNIVITRQSQWSAPGAERADSVAGAIALAAAETVWIIGGGEIYRQAMDYATDLMVTEVDTDIPGDAYAPAIDGEWQVEDAPWSQSLSGLRYRIRRFARDTAPATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5B7</accession>
    <name>A0A231H5B7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin reductase</fullName>
            <ecNumber evidence="3">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcD_3</name>
        <name evidence="3" type="ORF">B7C42_04165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43926">
        <property type="protein sequence ID" value="OXR43926"/>
        <property type="gene ID" value="B7C42_04165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="323"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="41333" checksum="DD50CE0E99A7A795" modified="2017-10-25" version="1">MTAPIVIIGAGLAGLRTAEELRRAGYEGGLILVGDEQRLPYDRPPLSKQFVRGETEDTTLRPAEFFAEKNIELRLGLAATGVDTAARTVTFDDGSVLEYGQLIIATGLRPKRIPGLPEAAGVHVLRRHEDAAALRDGLATARRALVVGAGFIGCELAASFRSRGVDVVLVEPQPTPLAAALGETVGRLVGRMHRDEGVDLRCGVGLSSLQVEDGAVTGATLADGCTVAADLVVIGVGSAPITEWLAGSGIPLAEPQAGGGVLADEVGRTSVEGVWAVGDVAAWRHDNGRHKRVEHWTNAGEQARLLTTALLGGDVPAAARVPYVWSDQYDLKIQVLGTPAGADEIRVIEDDGRKFLAHYFDGGVLTAVVGGGRTAQVMKMRAELAANARSAAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Q5</accession>
    <name>A0A231H5Q5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YtcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytcD_7</name>
        <name evidence="2" type="ORF">B7C42_03602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44046">
        <property type="protein sequence ID" value="OXR44046"/>
        <property type="gene ID" value="B7C42_03602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="128" mass="13892" checksum="9FFC3491870C53A1" modified="2017-10-25" version="1">MSGYDEHAGELVADCRLRAATDLFAHTWDPVVLVGLLGGARRRSGLRAEIGGISDKALTEALRRLLGHGLIERRRYAQAPPRVEYALTPLGLSLVEGPMRALGEWIEIHGDALLDAGEPDGEREDEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6H0</accession>
    <name>A0A231H6H0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">idi</name>
        <name evidence="8" type="ORF">B7C42_03877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44316">
        <property type="protein sequence ID" value="OXR44316"/>
        <property type="gene ID" value="B7C42_03877"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="44"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="187" mass="20263" checksum="C2201EDDFD5D1773" modified="2017-10-25" version="1">MTGTHTTSTDSTVDRESLPVELVDEQGRPAGICPVSDAHTAPGRLHRAFSVLLFGPDGRVLLQQRAAVKTRFPLRWSNTCCGHPKPGQSLAEAAAVRLGEELRIGAELREVGVYRYRADDPATGRVEDEWDHVLIGEFTGVPGHPDPAEVAALRWADPDRLDSDIDSAPADFTPWLHGVLATARAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H720</accession>
    <name>A0A231H720_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44724">
        <property type="protein sequence ID" value="OXR44724"/>
        <property type="gene ID" value="B7C42_03518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="811"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="875" mass="92189" checksum="9AD4627A1A9454AC" modified="2017-10-25" version="1">MAVWKWPLVGRDAELAFISAAMRGRDHSQPGVVIAGPPGVGKTRLAREALAKAVRSGARERWVVGTKSGRSVPLGALSRHLQEDGAASEPGRPAIPAARALAARIEGRRVVVGVDDAHLLDEQSAMAVQQLVLTGTTPVVMTLGTTERAPDAITSLWKDGYLERLDLLPLSLREVTALLETVLGGELERSSAERLWRLAGGTVLFLRLLVTAEREAGRLRLDSGVWRWSGDIGLPTTLTCLIEAQMGALDPLVREVADILAIEEPLTVSALEELAGRRAIEQAEERGLVTVQLRDGQGMSVRLAHPLYGEVRRDRTGTLQAVRLRGRIAQALARPPYTSAARLRAAVLTMQSDLPPQPALFLDGARIALSRGDAKLCAQLAGAAATAGSGLPARWLRAHALAMNGDGAQAEHELAALAEVGDDAQRARVAIDRVTNMFWSLGRVGDAERIRAQARTSITDRDAQQSLIALGAVLDLCRAHPRVAARAARGVLDSGCADPAAVAPACYALVGALGVLGRTDRIGPFADRGAIAARSHETSILPIAVHMEHVHALVNAGYLPRAQALAADVRAMAADAPAPIRTAAMFVDGRVALRCGRLAEALRALREATSGLGGRDAFGMRYACRVALAQAFALTGDAGGAAEAMAAAEAARHPGYSFLDPELMRVRAWVVATGQQQPSAGAIAIAHEAADLAAKNAQLSLEVLALHTAVQFGDISCAERLSRLASSVDGPRAPAAARQAAALTDRDGAALDEVSAEFERYGDLLAAADCAAQAASAHAYRGMRVSALASAARARRIATECGAHTPAIRAITAIDARLTDRQREIATLIGQGLTNQQIADRLIVSVRTVEGHIYRAGRQLGVNTREALAAIVCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H730</accession>
    <name>A0A231H730_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44691">
        <property type="protein sequence ID" value="OXR44691"/>
        <property type="gene ID" value="B7C42_03485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="42"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="32366" checksum="E506F6C1B161A6C9" modified="2017-10-25" version="1">MTARQTASTVGTVTFRSESSTVPSVILNDGHLIPRLGFGVFQVPEGQTFDTVTAALEAGYRSIDTAAAYGNEAEVGRAIAESGLARDEVFITTKLWNADQGYDSTLRAFEASMERLGFEYLDLYLIHWPVPSADRYVDTFRAFQSLKTQGRIGSIGVSNFQPEQLRRLIGETGEVPAVNQVELHPALAQNTLRAFHAEHGIATEAWSPLGQGAELKDPTVGAVAEQVGRTPAQVLIRWHLQLGNIVIPKSVNPERIRENFDVFTFELDAEQMTTLNALDTGSRVGPDPDTFTMGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H789</accession>
    <name>A0A231H789_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44794">
        <property type="protein sequence ID" value="OXR44794"/>
        <property type="gene ID" value="B7C42_02748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="31591" checksum="43F895CF3BAC48AD" modified="2017-10-25" version="1">MGFGSGSEQCAAWLYLPDGPPKPRPLVIMGHGLGANREMGLDRYARRFAAAGMGVLVFDYRHFGASGGEPRQLINIARQRDDWRAAIAFARTLKGFDATRIALWGSSFGGGHVLSIAHEDDYLAAVVAQCPFTSGWSSAMAKGPISLTKTGTLALADLLVGPIRRKPVGVRLAGRKRSAALMSASDVPEGFGRLAEESAQYQPKVAARVGMSVMFDSPWRRTKAIKVPVFYAVCDNDSVAPVGPTLKAAERTKHGIVKRYPIGHFDIYFDDWFEKAVYDQTEFLVSVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7C5</accession>
    <name>A0A231H7C5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44745">
        <property type="protein sequence ID" value="OXR44745"/>
        <property type="gene ID" value="B7C42_03540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1054" mass="118690" checksum="C91475EBBF0BE34F" modified="2017-10-25" version="1">MGIGDDRAQQPHETVRESGNRRLVEQIRRVREDGRLFAVTVDRRNRQLQIEFRDGSVEVDLLDGQSGQFQPGGIDVLEEQRHLEQRMVRRRPDRIQDLDQPLEGQFGVRERGQVRFAYPVQQIDEARAGFDLGAQHQGVDEHADEIVELAFTTPGHRGAQGDIRAAGQPRQQCREGRVHHHELGRVAGAGDLRHGAMRLRRDRERIHPADARGRLRPRPVRGQVDPLRRVGQRRAPERQLLRRRRLGIVLVAEQLPLPQRVVRVLHRQRRPRGRLTRDARQVGGHQVPDQRRHRRAVRRDVVRHHDHHVHVGGRRQHRHPQRHLGRDVESAQREAGDPVHHSVFADLDDRQIRHRGRGQHVLIPHAVHGRVDGPQHLVPGDHVTHGRSQRRQVQLTRQPDGEGNVVGRGGGVELVEEPHPLLCQRQRHQLRPRPRHQCGTLCGRDGCFGANRQLLHRRRLEQVPDRDRGAERGVHPCDDPGGDQGVAAQGEEVVVAADPLGAEHVGEHPGDRFLDRRDGSAELALPQHLRLGQRTPVQFAVRSQRQRLQHHDHVGNHVAGEEFAHRRAHRSGVGNLPGLRDDVTDQPVTEVVIGVDHRHGLADAGAAQQRGLDLTQFDTEAAQLYLLIAAPGIFQGGLTVETGPAADIARAVHARTGRPERVRHESSRGQARAAQVSARQLASRDVHLAGDTDGSRMQAFVEDVGFQARQRLADHAGRMIGQTLVERQERHVHRGFGDAVHVHQSRRGRTVPLVPAAELAQIQGLATEDDVAQGELARTRHRGIPAGVILRGAIGLGQLIERRRRLVQHRDLLANQQLAERFRRTRGQVIDHDHRTTGGQRTPQLPHREVEGEGVEQRPHIGLVEVEQQLRVREQLQHVAMGDAYALGHTGGTRGVDDIGQIGRAQRTHAVAVGDRSVGEVPGLFQQHRRQFRGGQFRPHGGRGEHTRRLGIRQHEFQPLRGVAGVDRQVGRARQEDTQQRDGQFLGPRNRHRHQGFRAHALSDERARHTIGAPQQLTEGDGGVAEPDGHRARAPLRLRLDQIHQRHRRDQRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7H1</accession>
    <name>A0A231H7H1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44799">
        <property type="protein sequence ID" value="OXR44799"/>
        <property type="gene ID" value="B7C42_02753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="180"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="481" mass="49951" checksum="CE3FB349AB094511" modified="2017-10-25" version="1">MPEDTPTTAGARSHRGPGRPSDTRPGGPAAAADATRAGWAVGADGVREPGGALHDGVVTAYADPGLGGVRLPRGVLHDGSVRADDEACESGERPGVDAEASRAPGVAGDGPNFAGAEAAGGSGDSRFVGAVTAGSEFGASQVDRSALRHHGDRDVRAGMLDFAVNVRGDAPPKWLLRRLAARLPELGRYPSEAEADAVRAIVAARHGRAPEEVLLLAGAAEGFALLPRLASRLAAVIHPSFTEPELALREANVPVARVVLAPPYELAGARVPEDADLVVLGNPTNPTSVLHPRAVIESLRRPGRIVVVDEAFADAVPGEPESLAGQSYPDILVLRSLTKTWALAGLRCGYLLGPPALLARLNHGRAHWPLGTLQLEAIAATCEAHAIAEAQASAARIGAEREAMIPRLRALGIAVHEPAAGPFLLIRVPDGELLRKHLADENIGVRRGDTFPGLGNEFLRLAVRDHAAVDRLIAAIEAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7P7</accession>
    <name>A0A231H7P7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease YhcR</fullName>
            <ecNumber evidence="4">3.1.31.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhcR</name>
        <name evidence="4" type="ORF">B7C42_02766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.31.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44812">
        <property type="protein sequence ID" value="OXR44812"/>
        <property type="gene ID" value="B7C42_02766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011826334" evidence="1">
        <location>
            <begin position="30"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="56"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="369"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="559" mass="57866" checksum="82D686A0310FE9E8" modified="2017-10-25" version="1">MGVLRRMAAGGVVAMSLVALSGCGGGSETAHQGAIPLVSTGDLPSAQAGEVHLFGFNDLHGHLEPPEASNGQVGEYTAGGAAYLATHLQRLRAAYPDSAVVSAGDNIGASPLVSSLFHDEPTIDFLNQAGVAASAVGNHELDHGVVELGRLRAGGCALDGCSPGEPFTGARFDFLAANLTDSRGEPPAGVRPWTMLTIGGHKIGVVGVVTPDTVNLVFPEGIRGYTFGEEAEAINKYVPAMKQAGAETVVALVHDGGAQGTPAKTTDYNGCADISPDVPALAAHTDPAVRVLLTGHSHQAYNCEFDGKVVTQAASYGRLITDVTLRFDHGKVSAHAVNRVVTRDVAPDPAVDKLIGFFSGQAAPRAQRVVGTATAPLTRSDRGGGESPLGAVIADAMLDVTHDSARAVAAFMNPGGVRADIGPGPITYGSIYETQPFGNQVVTVTLTGRQILDLLEQQWDNKSKPAVLSVAGISYAYDDKAAPGHKVVADSVRIGGQPVNPVATYRVTTNNFLASGGDGFAVFTRGTDTTVGPTDLDALETYLRDRGTVGPPEERVQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7T3</accession>
    <name>A0A231H7T3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetaldehyde dehydrogenase 2</fullName>
            <ecNumber evidence="6">1.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acoD</name>
        <name evidence="6" type="ORF">B7C42_02951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44994">
        <property type="protein sequence ID" value="OXR44994"/>
        <property type="gene ID" value="B7C42_02951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="27"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="505" mass="54409" checksum="B2BE27C1003678B9" modified="2017-10-25" version="1">MIYAKPGAEGSIVSYADRYDNFIGGEWTAPVEGRYFENPSPVDGETFCEVARSSAADVELALDAAHGAADAWGATSAADRANILNKIADRIEANLDQLAVAETWDNGKPVRETLAADLPLAVDHFRYFAGAIRAQEGGVSEIDADTIAYHFHEPLGVVGQIIPWNFPILMATWKLAPALAAGNAVVLKPAEQTPASIMKVVELIADLLPPGVLNVVNGFGVETGKPLASSPRVAKVAFTGETTTGRLIMQYASENIIPVTLELGGKSPNIFLPDVLAADDAFLDKAVEGFVMFALNQGEVCTCPSRALIHSSIYDEFMARCLERTKAIVSGNPLDSETMIGAQASNDQYEKILSYIDIGRKEGAEVLTGGSQRKVDGLPNGFYVEPTVLKGTNDMRVFQEEIFGPVVAVTTFDSTEEALAIANDTLYGLGAGVWSRDGNTAYRLGRGIKAGRVWTNCYHAYPAHAAFGGYKKSGIGRENHRMMLDHYQQTKNLLVSYSPNKLGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7T6</accession>
    <name>A0A231H7T6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative propionyl-CoA carboxylase beta chain 6</fullName>
            <ecNumber evidence="5">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">accD6</name>
        <name evidence="5" type="ORF">B7C42_02861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784172.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44905">
        <property type="protein sequence ID" value="OXR44905"/>
        <property type="gene ID" value="B7C42_02861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="4">
        <location>
            <begin position="225"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="481" mass="50140" checksum="1FCA83D9C9012C21" modified="2017-10-25" version="1">MTIMAPAQADATTDPRDPLGRLQRFFDPGTVLPLHPRDKSGVLAAIGEVDGVRTVAYCSDATVMGGAMGVDGCKHIVDAIDTAIDSRIPVVGIWHSGGARLAEGVEALHAVGTVFEAMVRASGLVPQISIVVGFAAGGAAYGPALTDVVIMAPEGRVFVTGPDVVKSVTGENVDMATLGGPETHGKKSGVCHIVADDENDAMHRGRRLVSMFAEQGEFDLSAAAHGDVDLKAMLPASAKRAYDVKPVVRELLDKIPSPDGDDESSFEELQGGYARSIVTGLGRLGGRTVGVLANNPLRMGGCLTSESAEKAARFVRLCNSFGIPLVVITDVPGYLPGVGMEWEGVVRRGAKLLHAFAEARVPRVTLVTRKIYGGAYIAMNARSLGATAVYAWPESEVAVMGAKAAVGILHKKAIAKAPEEEREALIERLTAEHETIAGGVGRALSIGVVDEVIDPAKTRSTIAAALASAPAKASHNKNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Y2</accession>
    <name>A0A231H7Y2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45044">
        <property type="protein sequence ID" value="OXR45044"/>
        <property type="gene ID" value="B7C42_03001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="14886" checksum="CDB50B6266CBD14B" modified="2017-10-25" version="1">MNPDLRIRFAVDDEALSRLHADAFGGDRTVVPWQARLERHSRSWVGAFASERLVGFVHAVWDGGNHAFLLDTAVAPDLRRQRIGSALVQALADDLRELGIEWLHVDFEPHLHSFYRDACGFRATDAGLLRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Y3</accession>
    <name>A0A231H7Y3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45123">
        <property type="protein sequence ID" value="OXR45123"/>
        <property type="gene ID" value="B7C42_03080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="9615" checksum="09DC62697A463471" modified="2017-10-25" version="1">MSGRMGERTCVAMLKRLDRLLSYEMKVSEFLGTLIILAVPYGIIGVIWTLTHTAHLKQMHGIDVVISFLGSIVCWPVLTFSNVCMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H833</accession>
    <name>A0A231H833_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45173">
        <property type="protein sequence ID" value="OXR45173"/>
        <property type="gene ID" value="B7C42_03131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012489087" evidence="3">
        <location>
            <begin position="40"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="626" mass="66613" checksum="D2D545F54BC8B4A1" modified="2017-10-25" version="1">MSGPTPPPATPPPRRRRILAPTATLILAAGLTATAVAQAQPPVTPPSIVPAQPSVTMSPAPRWHTEPPTTTPPSPSAPVSPDPQPPPGPRTPVDPPSPVYPGTGTLHDYPSEGDCGVTNISGCVAEAIDGFFHRLVTSALNPLLNLVSHTLLTTPDLTALPHVRQMWDSSWQLVLALYVLVVMGAGVLLMVRETLQTRWSWRELTPRLVIGFVAGALSMAGATGAIRFANALAEAVSGNGVDADSAAAALRQLTDTGPSGGIFMLLLGVALVVILVVLMVAYVVRIAITVMLVIAAPLALMCHALPGFESIARWWWRSFGACLAIQVVQSLILVTSLRVFLTPGDWGFFGPNSQGMVDQIIAIALMGILVKTPFWLLSVLRIGQGRTLAGSIARSYITYKTLGALKGTHTAATSKRAAATSAVARRPPRPADPYARVRATRDGQLMLPLEGVHRVKRQPNPAAGQPTSRSAAAPTRTPRGKQLAFDFDLLATSDPYRGIRPGRGGQYPLPIPVAKVRRPTPPPEPTTPAVAKRAPAGSTRGRQLSFDFDPPAAPDPYDRVRPLRSGQYPLPIPATRVRPTPRPPTRVAPPLSTPGPKRSAGRQLHLPLPDLPVRRRVPRTPGRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Q6</accession>
    <name>A0A231H8Q6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45245">
        <property type="protein sequence ID" value="OXR45245"/>
        <property type="gene ID" value="B7C42_02370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12654" checksum="921B26E868A6A808" modified="2017-10-25" version="1">MDLMKVIAFDRFKPGVTLETITPYLPEEVANVWRLWKAGIVRENYARADESGVVIVFEVDSVAQARRYVDDFPLSKKGFLEWTYVPVTAPLPLEALMDASVDTGEPYDRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8X3</accession>
    <name>A0A231H8X3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid-associated protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybaB_1</name>
        <name evidence="2" type="ORF">B7C42_02424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513580.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45299">
        <property type="protein sequence ID" value="OXR45299"/>
        <property type="gene ID" value="B7C42_02424"/>
    </dbReference>
    <dbReference type="GeneID" id="66719150"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="110" mass="11320" checksum="C703C22F85284DD3" modified="2017-10-25" version="1">MSAEMDALVAAATNKLEALEAALYNLKNVRGRFTAEDGSVSVEVDSDGALVGLDLSEAVTSHSPAEVGQLIIWACQQAAQNAGEQRSEVVATLNSAFTAPESGNVGGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Z1</accession>
    <name>A0A231H8Z1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pknJ_2</name>
        <name evidence="9" type="ORF">B7C42_02444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45319">
        <property type="protein sequence ID" value="OXR45319"/>
        <property type="gene ID" value="B7C42_02444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="458" mass="49219" checksum="DEE4EC4D2F666140" modified="2017-10-25" version="1">MAQTLVHGQVFAGYRIERLLGAGGMGEVYLAHDRDLPRYTALKVLNPAFAGDEDARHRFLREADTIARLSHPNIVTVYARGQEGDRLWMAMQYIEGTDVAAVLRNGPMHPEHAVAIVTEAAKALDFAHRAGVLHRDVKPANILLAQGDSKQVFLADFGIAKILDHTNELTRSGEVHASLRYAAPEQLDPGVPVDHRVDVYALGCTLYHMLTGAPPYPGASPAQLVHAHLNLPLPAASRQNPWLPPAFDAVFARATAKNPQERFSSCGELAAAAHYASAASASPAPHPAPASGSGRHWVWIVAAIVAVLVVLGTGGAGAFVLYHNRSTDDSQRSADAARDAACAFGRTVSTYDYTKFADYQTAVLDATTGDLKTQMQSTMSTLRDVVTQSQARSHVSDAQCFLKTSDADRAEVAAIITQALTNNTSSTERSSQVSVLLTMQFVDGRWLAAKLEQLAAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H937</accession>
    <name>A0A231H937_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45207">
        <property type="protein sequence ID" value="OXR45207"/>
        <property type="gene ID" value="B7C42_02332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="35747" checksum="3A97DC045E622AB1" modified="2017-10-25" version="1">MVAEHSSDLPAYADYVSTVETAPRAAPRSPFAVIVAVGVILVLAPLFTGMFPRAVKGEAMIGSFAPFVTSSSIDGYRSDLAVLDAARTNVLTLRSQGIGSGSYDRIDAFVRDYPGIRADLSGTLDSIDHNRGDYQRVADLPPLGTLPWLLALAGLALVATGVFGLRRAEAGNRAPGWRISAALVGLALITISLAGGLFTATSAGQPLIDGFRPVLTHDEVRKVQGYFVTLVAADGELNSRFTGDVRAARPDADLSAITALEQRWQPMTSHFAALIGAMNDNVARFDAVAALNDSTKPLGFTAFRGLGWFFLIPGVVVVAASVWGLRTGDRTRDSGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9R1</accession>
    <name>A0A231H9R1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043751.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45589">
        <property type="protein sequence ID" value="OXR45589"/>
        <property type="gene ID" value="B7C42_01881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="21319" checksum="5210CDE938A9B721" modified="2017-10-25" version="1">MTSPRPRGRPRDDTVDHRVLDAAVEELAEKGIAEFSITSVAARARAAKRSIYARWPRREDLILAGMSTLAAGLVPPHTGSITGDLTVLLDRIAAVFVEPRLSILQRCAAEIADYPDMYAVFKRDSIDRCLAAIEDALHDAVTRGEIRADINPGTVADIITGTIAFRASTHPSDVLPADRREELTALLLDGLSPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA08</accession>
    <name>A0A231HA08_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45698">
        <property type="protein sequence ID" value="OXR45698"/>
        <property type="gene ID" value="B7C42_01990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="25589" checksum="110D23384738C26D" modified="2017-10-25" version="1">MPTTLAPTRPDTFDMLVVHNAFRSHFRALPGLVARVDAGDVERARQLAAFLDELCTGLHEHHTGEDELMWPLLLERAPMHAGAILRMEEQHERIAELIRRARRDAGEFVTAASASVRDRLADTLRVLAAALDEHLAEEERQVLSVVEEVMTVAEWRALGERGRAQMPRNRQLIFLGFMMYTASASQRRKLLAEMPPAARLAWRVLGRRGFAREYRAIYRSDPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA75</accession>
    <name>A0A231HA75_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monoterpene epsilon-lactone hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlhB_2</name>
        <name evidence="2" type="ORF">B7C42_02062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.83" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45770">
        <property type="protein sequence ID" value="OXR45770"/>
        <property type="gene ID" value="B7C42_02062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11255" checksum="2BE3B7D388B29F8B" modified="2017-10-25" version="1">MTGLKQAGRWYAAGRALDDPEISPAFADLTGLAPAIVFIGLRDILLPDARRVRELGAAAGVPVELHEYPGMPHNWIMKKIPEARRATDELVVFLHTAAAQTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAD7</accession>
    <name>A0A231HAD7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GTPase</fullName>
            <ecNumber evidence="2">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45697">
        <property type="protein sequence ID" value="OXR45697"/>
        <property type="gene ID" value="B7C42_01989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="47"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31200" checksum="BE5AC38A5F412712" modified="2017-10-25" version="1">MTTAGREAKRLLAAARDGSLRATGRLLSMVENGSRDEVLALLGAATTSRVLGVTGPPGAGKSTTVAALVGAYRAQGARVAVLAVDPSSPYSGGALLGDRIRMSAHVGDPDVLIRSVATRGHIGGLAAVVPAAIRLLADLGYERILVETVGVGQSEIEVAAVADPTVVILNPGAGDAIQAAKAGLLEVADILVVNKADRPGADRTVRELRGESSAPILTLVAENGTGIPELARAIDAHQRNDDPERRTARARVQILSLVHTRVRAHPDLDRLAADVAAGALDAYTAAQRLVPRSAAVPAPAIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAR8</accession>
    <name>A0A231HAR8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46043">
        <property type="protein sequence ID" value="OXR46043"/>
        <property type="gene ID" value="B7C42_01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="11447" checksum="8647B49D874D09EE" modified="2017-10-25" version="1">MFTWYVALLAISGIVMIAMASVQQGQSNATRSFNGIFGGLFLGYACYLAVLFDGGSYLIFFHAFIVPVTMVVNFFRNRTPRPKLTETQKAWREFQRAGQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB09</accession>
    <name>A0A231HB09_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781330.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46035">
        <property type="protein sequence ID" value="OXR46035"/>
        <property type="gene ID" value="B7C42_00998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="436" mass="45344" checksum="26AC3AEDE4FCCFFB" modified="2017-10-25" version="1">MRTHHAVLEMITAALATLVAGLSLMLPNGFRWASQTSVLQLDMLAASQPRAIAVGAIAALIVAVFATTVNHALVAWGTALCGVVTMFLAHLLAETGDQSIAPATLNYLEALAGGILLGGIAVAVLRGWFQVFGWTLGALAAVVFGQLGSTSTGTVRGGVMSAPGWSTRTLPPLWLIVVTLVLVIVGMVVNRKQDTVERRSVELPMAPIIAGLIFVIGRVFSAEWLARHADSTGNVVFAASLTVTAAAVAAFLLPRRDGVLILLAVALSAVGGALIPARLPVWSVTPLVLLIALGLVAGFRRPMPMLAMSTLAAMALYCALVSGHRIHSGVQAAVLSGLLAVVAGYSFGSAAPRYNPTRVLGVAIIFVPSVVTALRDHLDRPQCVSDPGQWYLCPAPAMSSAAPYWTALGVTVVCAASLMALRSWRKPATTESVADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB67</accession>
    <name>A0A231HB67_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid-associated protein EspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">espR_1</name>
        <name evidence="2" type="ORF">B7C42_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45967">
        <property type="protein sequence ID" value="OXR45967"/>
        <property type="gene ID" value="B7C42_02260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="14429" checksum="E17F075FD604E43E" modified="2017-10-25" version="1">MRFADRFNDVISQWEQVHGTRMTNRALAFRVTQAGHPVSATYLSQLRSGNRDNPSQALVETVARVLAVESTRFNDGGPGDPAPGDDLVSSALDDPALRRLLTTAAGLSASSIELLSDVAAKLRLAEGLAPGTTAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA8</accession>
    <name>A0A231HBA8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781516.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46224">
        <property type="protein sequence ID" value="OXR46224"/>
        <property type="gene ID" value="B7C42_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011306280" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="2">
        <location>
            <begin position="61"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="38635" checksum="B1CCF0B7FF968809" modified="2017-10-25" version="1">MRRLSALAGACAAVALLGLTASPAGADPNNINPIPGLNGINGLPQLPGPTQAVYQATGMASPNRTQNQNVLGTDLGIMWDDGRGQMITAYGDTAGLGVPNVLAGSIWAWRSNVLFRSPAGADPSAGVNYTSFVDNPLPSPKIPGIEISFIPTAGVSVNGVQYMSMMSVREWGPDGHWDTNFSTMAVSGDDGQTWAQLPTTRRGNENGFQSFQQNAFLKAGGYVYKYGTPAGRNQPGFISRVKEADIANIDAYEYWDGGAWKPKDANAAKPIVGGVGELSVQWNAHLGQYVMLTTDPFDSVVMRTAPNPEGPWSAPRVLIDVRDLPTMYAPMIYPYQTGSDLYFLLTMHNQYNVVLMRSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBU3</accession>
    <name>A0A231HBU3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_3</name>
        <name evidence="2" type="ORF">B7C42_01379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514081.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46413">
        <property type="protein sequence ID" value="OXR46413"/>
        <property type="gene ID" value="B7C42_01379"/>
    </dbReference>
    <dbReference type="GeneID" id="66717923"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="30674" checksum="0B31DEF40D764154" modified="2017-10-25" version="1">MSSTYVPPLLRPLQRIRSSAGAPRDWLARVGHQVFFFLRSIGSMPLALKHYPKEVWRLLSDVTWGNGSLIVGGGTIGVVLILSAFGGMTVAIQGYTSLNLLGLSPLTGAISAFATTRELGPMLATLAFAAQAGCRFTAQLGSMRIAEEIDALESQAIRPLPYLVSTRMIAAMIAIVPLYCLALPVAYLSCSITVGFIGGTASGTFQHYFYQFLVPHDVLWSLLKAILFVAITTFIQCYYGFFASGGPEGVGVAAGRAIKLCIIAVVFADLFMTLAIWGVNPGIRISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC68</accession>
    <name>A0A231HC68_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781835.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46470">
        <property type="protein sequence ID" value="OXR46470"/>
        <property type="gene ID" value="B7C42_01439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011277261" evidence="2">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="7051" checksum="CA58BD7F5813CEBE" modified="2017-10-25" version="1">MQLGSSRKSGRLRNRLIAAGIAAAAGGAAWAAASRRPQLPEPAAEPPRLGYADGASASGTAANPADDAAHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCS1</accession>
    <name>A0A231HCS1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041776.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46773">
        <property type="protein sequence ID" value="OXR46773"/>
        <property type="gene ID" value="B7C42_01751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="11259" checksum="6BF4BDD715214CDC" modified="2017-10-25" version="1">MSSKQVQVDPDKIRTHAKNVQGVSDSLSVALQAGQAVSVPTDAFGKLCSFLPPLFLDTVEDDGLEAIKTAADALNADAGTLEQVATSLQNTDSTNASDLGSVRPEATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCX8</accession>
    <name>A0A231HCX8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46652">
        <property type="protein sequence ID" value="OXR46652"/>
        <property type="gene ID" value="B7C42_01626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="25225" checksum="B62ACD6B597E8C44" modified="2017-10-25" version="1">MTEPTANQPVPVPSTLFNAVGSALSQVFTAIGKPRPYFSQRQAVAGAIWAEINNWPIPEPTIAAAFGQKARPDTDVPVMSFDDFRNVILSTTDYIARNLASPGADIEFSDVVLAEWYADYVNGHDLWMSGFSAGQAAAAGDAGARNTKALGLIDAWLSDESPTDDERQRSIWRGIREIRSALSRCAHVKLDCSPVDGDVWYTNWKCEDCGRGMVVLAGLTVDGARKALDGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD54</accession>
    <name>A0A231HD54_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46637">
        <property type="protein sequence ID" value="OXR46637"/>
        <property type="gene ID" value="B7C42_01611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="42" mass="4535" checksum="FF5A40C252084A01" modified="2017-10-25" version="1">MCNNPFDLIARLHAALHGLLYAPVGVLPPSYDDAIIVLRFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDH0</accession>
    <name>A0A231HDH0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46944">
        <property type="protein sequence ID" value="OXR46944"/>
        <property type="gene ID" value="B7C42_00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12443" checksum="9CFD5BD6E67CD385" modified="2017-10-25" version="1">MWERQGELQERSGGTSGGIRIGRVVGDRLWSGKRPGVIKSVVACVIDSFDDQWLRQMLGVRDSFPEADELAVDFGNIRSDRRNVGCDVLYLGALSGVRAESTPPPMSVMSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI8</accession>
    <name>A0A231HDI8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ESX-1 secretion-associated protein EspI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">espI_1</name>
        <name evidence="3" type="ORF">B7C42_01786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46808">
        <property type="protein sequence ID" value="OXR46808"/>
        <property type="gene ID" value="B7C42_01786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="443"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="711" mass="73882" checksum="1214921F5AD0693C" modified="2017-10-25" version="1">MGDTAADQDNPTSLPSHDESDADTTASDGPAGVTSEAEPNGAPAEESAEFEHAASGIIPPVPDGIEQTTFAPGPQFGPDGFAPPEQGGFAPGPFAPPGANPYPPNQGFAPPGFPMNDHAGPFAPPGDPNGFPPPWAGGPGPDGFVPNGFPGEQGGFAPPGGPADQGGFPPPGHPGEPGGFAPASFPGEAGNFPPPGNPGDPGGFAPGGFPGEQNGFAPPGEQGGFAPPGNPGEPGGFAPHGNPGDPGGFAAQGNPGEQGGFRSGAGDPGPGYGEVRQETPYGEIRQEIGADGMVRRVFDERQGPPSGPEQQGGAADAGGPIFSWAPPPLPSTPPQQPQQYQPQQQGGWQGGPGPQQQLPQAYQQQPPQSTFQPQHMTQPVQPGSSVNDLNLLKRARRSPRSGWRRAVHKVTGGAINPGESSADVIYRELVDRVNQPVRGDYRIAILSLKGGVGKTTTTVGLGSTFASLRGDRVIAIDANPDLGTLAHRVPRQTRSTVRNLLEDQHIGRYSDVRAHTSQAPSRLEVLASEQDPAVSEAFSEADYRRAIGILQQFYNIILTDCGTGLMHSAMAGVLDMASSLILVTSPAIDGARSASATLDWLEHHGYSKLVERTVVVVNASRRGASTVDLDQLRKLFLDRTRAVQVVPFDDHLAEGAEIDLELVGKPTRRALLELAAMVADDFGYHVPQPPFPGPQTQYPGPQGHYPGPQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDZ8</accession>
    <name>A0A231HDZ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyrosine-protein phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iphP_1</name>
        <name evidence="2" type="ORF">B7C42_00325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47203">
        <property type="protein sequence ID" value="OXR47203"/>
        <property type="gene ID" value="B7C42_00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="27985" checksum="1BB3F119AAA07279" modified="2017-10-25" version="1">MPSNPIAQEFDATRRWVDFEEIDNVRDLGGLPVDGGGTTRFGVALRSSTLQQATEADVALLLGSVGMRTLIDLRLPDEVEREGYGLLAATAIEKVNLPVRKSAQSSLAARDLVPDKTRVDLARLYGQLLAGSPEEIVAAARLVADADRQAVVFHCAAGKDRTGVLAAVLLDAVGVAPEVIAADYALTNERMTRVRNRLDALNSYSGLPPTSTGILAVEAAVMLRFLDELRRDHGGAARWLREHGLTAEELTMLRYALVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEE7</accession>
    <name>A0A231HEE7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47115">
        <property type="protein sequence ID" value="OXR47115"/>
        <property type="gene ID" value="B7C42_00237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="9099" checksum="C0015106E9DE1E15" modified="2017-10-25" version="1">MEKSIYSAEYQRLCGFLRQLRREAGLTQVQVAERLDVPQSFVSKYESGERRLDAIELLHVVRALDSTLLRVAAFIEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF11</accession>
    <name>A0A231HF11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779881.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47464">
        <property type="protein sequence ID" value="OXR47464"/>
        <property type="gene ID" value="B7C42_00589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011287141" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="8985" checksum="07407F70BAD9CC0C" modified="2017-10-25" version="1">MQITSVRGAVVAVAAGAAVLGAPAIAQAAGLPLEPATPQEEVTTQHAGPVLALWDPQTGSSSLSSNVNARGLCIFQSISAQGGLDCFNGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF32</accession>
    <name>A0A231HF32_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ywqF</name>
        <name evidence="12" type="ORF">B7C42_00449</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47326">
        <property type="protein sequence ID" value="OXR47326"/>
        <property type="gene ID" value="B7C42_00449"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="314"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="246"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="433" mass="45551" checksum="C2AFBBA08FF8E8DC" modified="2017-10-25" version="1">MSERIGVVGAGYVGTTTAAGLAHLGLPVTAVDVDAGCVERLRQGRTELQEPDLEPLLRQGIRAGLLEFDTDIERLAQAEVVFVCVPTPATPSGAADASAVQEVLAVLFGLLSPGAIIVLKSTVPVGTAREAAAAAGRHGLHVVSNPEFLRESHAVYDFLHADRIVIGASDAGAGERIARLYQGVESPTVQIVDFESAEVAKYASNAFLATKVSFVNELAELCEKVCADIELVGECLGSDPRIGAAFLRPGPGWGGSCLPKDTEALLHIAHDKQVNLGVLEAAVAANRAQTDRTVATVARVLGRSGGDLDGVRAALFGLTFKAGTGDLRDSPARRLAAALAGHGAQLCVYDPTVAPVRGRDLGLPARVRIVDDPYDAAQEADAVVVATEWPEFAKLDWPRLGTLTRRRVIVDTRNLLDAEALRRDGFTVIGNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF56</accession>
    <name>A0A231HF56_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AhpC-TSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47603">
        <property type="protein sequence ID" value="OXR47603"/>
        <property type="gene ID" value="B7C42_00728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="19582" checksum="2401A5963D70B3A5" modified="2017-10-25" version="1">MSAPTTIASRTLTAVTGEPIPVPDPDRLIHLQFRRFAGCPICHRHLRTFVTRHAEIAAAGIREIAVFHSAAAELTGYAADLPFDLIADPDKTLYREFGVESAPRALLHPRAWPGIALAIGSAVGPMARGEQPTPRGTPQGGRLGLPADFLIAADGSIAAASYGSHADDQWSVDELLSYAAELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF80</accession>
    <name>A0A231HF80_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable malate:quinone oxidoreductase</fullName>
            <ecNumber evidence="4">1.1.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">MQO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Malate dehydrogenase [quinone]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">mqo</name>
        <name evidence="5" type="ORF">B7C42_00735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(S)-malate + a quinone = a quinol + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:46012"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MQO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.4" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47610">
        <property type="protein sequence ID" value="OXR47610"/>
        <property type="gene ID" value="B7C42_00735"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052589">
        <property type="term" value="F:malate dehydrogenase (menaquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008924">
        <property type="term" value="F:malate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00212">
        <property type="entry name" value="MQO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006231">
        <property type="entry name" value="MQO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06039">
        <property type="entry name" value="Mqo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01320">
        <property type="entry name" value="mal_quin_oxido"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="521" mass="55954" checksum="9D2E25DFE091EAA9" modified="2017-10-25" version="1">MPALDKEVDHPVPNAAMTEKTDVVLIGAGIMSATLGALLRQLQPDWSITMFERLDAAAPESSDPWNNAGTGHSALCELNYTPQAADGSVDITKAIDINERFQVSRQFWAYGAENGVLADPSGFINPIPHVSFCHGADGVDYLRKRHAALSRHPLFEGMEFIDSPDEFTRRLPLMARGRDFSEPVALNWTQTGTDIDFGALTKQLLAYLGSSGVEIAFGNEVRNLSKKSDGSWTVKVRNTRTRTTRTIDAKFVFVGAGGYALPLLQKAGIKEIQGFAGFPVSGQFLRCTNPELIAKHDAKVYGKAAVGAPPMSVPHLDTRVINGKPGLLFGPYAGWTPKFLKDGKFSDLLKSVRAGNVTPMLGVGVTELGLVKYLVSELLKSPAGKVNTMEEFIPRADGHDWELITAGQRVQIIRRKGAGGVLELGTAVIAAGDGSIAGLLGASPGASTCVSAMIDVLQRCFPSEYADWTPKLKEMVPSLGVKLSENQALFHEVWDWSTKALNLNGSGRADNTPIAAGVAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFC0</accession>
    <name>A0A231HFC0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">tsf</name>
        <name evidence="10" type="ORF">B7C42_00664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503639.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47539">
        <property type="protein sequence ID" value="OXR47539"/>
        <property type="gene ID" value="B7C42_00664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="67"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="29449" checksum="60266C21B2A3AAEC" modified="2017-10-25" version="1">MANYTAQDVKRLRELTGSGMMDCKKALEETDGDFDKAVEVLRIKGAKDVGKRAERATAEGLVAAQNGVMIELNSETDFVAKNDEFQNTAGDIVDAAAKVRPADLEALKAVDVNGKTADQVVQELAAKIGEKLELRRVVSFDGPVATYLHKRSSDLPPAVGVLVEYQGEGDAAAEVARAAAMQIAALKAKYLTREDVPAEVVAKEREIAEATAKEEGKPEAALPKIVEGRVNGFYKDVVLLEQSSVTDSKKTVKQLLDDAGVTITRFARFEVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFC3</accession>
    <name>A0A231HFC3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47671">
        <property type="protein sequence ID" value="OXR47671"/>
        <property type="gene ID" value="B7C42_00796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="422" mass="43915" checksum="5495BB9DB4CEECAE" modified="2017-10-25" version="1">MIAVDAPGIFARTAAAARIRVPSRAQVRTDTPAVERVMRRLGLSVGAGGVIMGLADVPEITEQAQFTPTWWTPAAGALAFGLFPVLALVSIRSSPRTIRLVSGCAAVAFLSAVATMLIGLDTHSIGANSVWLYRMLPLGVLAATLAWPALVAVAYLLIGSAAVALTNIYLAEQFTAASVLSAFARAVGLSALFLWCVVSALSAAARVDRESVAASRQAAEAAAAAARDNESARFAALIHDAVLSTLLDASRGSEPSDVLRRQAERTLDQLDEIRVESREPDVLDARAAVNFLRASVHEVNAGIRFTTRTWPGFDDLRMPAAAARTLAAALAEAVRNSLRHAAVPGRAVTRTVTCTISAGSIRVVFADDGAGFDANAVSADRLGISVSILGRMRQLAGGAGFVESQPGEGTAVTLVWGGDGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFF8</accession>
    <name>A0A231HFF8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_3</name>
        <name evidence="9" type="ORF">B7C42_00838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779477.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47713">
        <property type="protein sequence ID" value="OXR47713"/>
        <property type="gene ID" value="B7C42_00838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="42166" checksum="817E6E1515F24C66" modified="2017-10-25" version="1">MERTLFEPEHDLFRESYRKFLDQHVAPHHAEWEQSGVVDRQLWLEAGKQGFLGMAVPEEFGGGGVKDFRYNAVITEETTKGQYSGLGFSLHNDVIAPYLLELANDEQKQRWLPGFCSGEIITAIAMTEPGTGSDLQGIKTRAVKDGDDWVLNGAKTFITNGINSDIVIVVAQTDPEKGAMGFSLLVVERGMPGFERGRNLDKIGLKAQDTAELSFTDVRVPGKNLLGTEGMGFIHLMQNLPQERMSIAVMAAAAMEGCLETTIQYVRDRKAFGKPIGAQQNTRFVLAELATKTTAVRVLVDRFIEALNAGTLSAEDAAMAKWWSTEEQLDLITKCLQLHGGYGYMREYPIAKAYMDARVQTIYGGTTEIMKEIIGRSLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGE6</accession>
    <name>A0A231HGE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative zinc-binding alcohol dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_00890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47765">
        <property type="protein sequence ID" value="OXR47765"/>
        <property type="gene ID" value="B7C42_00890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="42386" checksum="6F9310C820E5CFEF" modified="2017-10-25" version="1">MKAVTWQGRRKVSVDEVPDPRIEEPTDAVIAVTSSGVCGSDLHLYEVLGPYMSAGDVLGHEPIGVVVDVGSEVRSLAVGDRVVVPFQIACGHCVMCDTGLPTQCETTQVREYGSGAALFGYSKLYGQVPGAQAQYLRVPHADFTHIPIPAGPDDSRFLYLSDVLPTAWQAVEYAGVPDGGSVVVLGLGPIGDMACRIAAHRGYRVIGVDRVPERLRRVADRGIEVIDLEQIGASIGDVIRDRTDGRGSDSVIDAVGMEAHGSPVAELAQRSAGYLPSMVSQKLMDTVGVDRLAALNSAIDIVRRGGTISLSGVYGGMADPLPMRILFDKQIQLRMGQANVKRWVDDILPLLQDGDPLGVETFATHRLPLSEAPRVYHDFQRKADGMVKVVLDPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSI2</accession>
    <name>A0A231GSI2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-dependent extradiol dioxygenase</fullName>
            <ecNumber evidence="1">1.13.11.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hsaC_5</name>
        <name evidence="1" type="ORF">B7C42_08345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.25" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000242">
        <property type="protein sequence ID" value="OXR39587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39587">
        <property type="protein sequence ID" value="OXR39587"/>
        <property type="gene ID" value="B7C42_08345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047071">
        <property type="term" value="F:3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="7073" checksum="8E3A11A50042261F" modified="2017-10-25" version="1">MSATLGRHVNDKMLSFYMKTPGGFDVEFGCEGLEVDDSDWIARESTAVSLWGHDFSVGMREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSM5</accession>
    <name>A0A231GSM5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000120">
        <property type="protein sequence ID" value="OXR39630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39630">
        <property type="protein sequence ID" value="OXR39630"/>
        <property type="gene ID" value="B7C42_08301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="78"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="30397" checksum="36A017D0828B9FE3" modified="2017-10-25" version="1">MGLRLEDVAPLMQWSASKLSRFEAGKSPSIRVLDVEAMCRIYDIDDPEVRAGLIGLAKQSTEKSWWQAFDDVITGNFDLYVGLESSSERLSIFQPHIVAGLLQIPAYARAVERGYYSDISEQELERRIQLRVKRQMLLTRKVKPVMVDFVIHESVLHTVVGSGKIMAAQCHHLANLPANVTVRVLPYETGFPAGLPTGPFAILDFGTDSKGRELSPTVVYIESFAGDLYLERVKDVARYRQAYNVIRHAALDVVDSKRRLRQIAREHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSR3</accession>
    <name>A0A231GSR3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000096">
        <property type="protein sequence ID" value="OXR39664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781939.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000096.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39664">
        <property type="protein sequence ID" value="OXR39664"/>
        <property type="gene ID" value="B7C42_08269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="71" mass="8087" checksum="D90A8FA90A335F5E" modified="2017-10-25" version="1">MSPPVGLPPVSSVCEPCGVYVIRPEVHADWHRRQDAKARRWDHIRDLVLRVFLARGYITTDEKTTVTDGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSW7</accession>
    <name>A0A231GSW7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <ecNumber evidence="3">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisI_2</name>
        <name evidence="8" type="ORF">B7C42_08361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000344">
        <property type="protein sequence ID" value="OXR39571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39571">
        <property type="protein sequence ID" value="OXR39571"/>
        <property type="gene ID" value="B7C42_08361"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR39571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="53" mass="5696" checksum="4F446C19CA0B5856" modified="2017-10-25" version="1">MKGETSGHTQYVHEVRLDCDGDTVLLIVDQEGAACHTGTHTCWDGDVLLAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSW8</accession>
    <name>A0A231GSW8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_08203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000078">
        <property type="protein sequence ID" value="OXR39724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782014.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000078.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39724">
        <property type="protein sequence ID" value="OXR39724"/>
        <property type="gene ID" value="B7C42_08203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011264467" evidence="3">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="31766" checksum="C9BBAF2FE7EFD81F" modified="2017-10-25" version="1">MIMAVLVITASIAGITAVAVALLRSSRDQAQRDLVRAQYLQHVAESAAQSQPPPQPPAQVSVISEPTTADWALVVGLPVALFFTGLVIFGAVYWRTRRAEQKQVKALGAVHDAIAEIKDPNDLLGLMEVNRRQMDAYDAQARGQGGSSHWSSLVAMTVGLGIVGAGLTITVVASEDATKYAAAIVAAVGTATGGYIAQTFIRLNSAAQDQVRYYFEQPLVQSYLLTAERFVLQMPAAERPKQYQALVEAALKQAAMVPQHRVPTLGERPLKKPADKPARSSKAARSSKPRVGLTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTD7</accession>
    <name>A0A231GTD7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782215.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39815">
        <property type="protein sequence ID" value="OXR39815"/>
        <property type="gene ID" value="B7C42_08103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="19443" checksum="C6754C47989413A1" modified="2017-10-25" version="1">MSNPLANIETPVLVARTAVLTEVEKTFKAHRTAHRAELAARMGPGSKITAFDPADDTLTLGTASMSNPDPVAYITDKDAFEAWCRVTFPDPLETWTEIDATDAEVIEVLRKHAPHLVIVHNSIKSTVIERGLDRAAKQDVPGTKRTKGKSTLTVTPAEHARAVVQAMVAQSPVLRELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTJ1</accession>
    <name>A0A231GTJ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39940">
        <property type="protein sequence ID" value="OXR39940"/>
        <property type="gene ID" value="B7C42_08003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="14695" checksum="47AC314E2464642A" modified="2017-10-25" version="1">MRSVRASDFNPTVLVLSTKLAHQYVAASIATGTPSDNISRTPAKSPAATCPAPDHKREAGVVHDPPARTDNTGSTSDPNAKFRNRCGANGIAEATPMIRISIATTTTPATSEFATTCSTAETSGRCRPVMWWSTWSVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTS6</accession>
    <name>A0A231GTS6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043596.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40023">
        <property type="protein sequence ID" value="OXR40023"/>
        <property type="gene ID" value="B7C42_07907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="211" mass="21735" checksum="06EF31DDBCB92E8D" modified="2017-10-25" version="1">MHPHPTHHAGLTALIGLLGIATLTGCTTPGDHIAPPVTSSPADTHAAPTHVTATAYQGISLPAAEEGPHTVTGAVATGFAHTPAGAALAAIHATVRMSVAPDDQWATIGQEMLAPGAGRDDWAVARAQMSITTPITGPPPKILGYRITGYTPDRADTAIYTQQPDTSLTCNTATVIWQAGDWKLLLPDGHHPALVTAANALPTDTILLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTV9</accession>
    <name>A0A231GTV9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40046">
        <property type="protein sequence ID" value="OXR40046"/>
        <property type="gene ID" value="B7C42_07891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="571" mass="61002" checksum="0FBD590DF0ACBC3C" modified="2017-10-25" version="1">MNNDNEARKARRPRTTTVAGIRVLTSQARAEVEMAAARRGLAAVRARWVLSSDDHRRATAARRVEDSVRDGFAVPAAGLTDRGYRGVGGGRATVVAATPEWRATTVQVAGLWPFAVGATAPVVGCPVGSHYVTGAPVHFDPMSWFARGYITAPIAFVLALNGFGKSSLIRRLATGAVAAGETVLCMGDTKPDYRDLVEALGGQVVDLGYGHGSINPLAVGALGTIIDRLPDPDQRRQVAARVEAGQVNIVAGLIELVRGSRVADYEETLIAAGLRELYSPAGGFSPELPPRLSDLLATISGGADRLRQFAEEDDDVAFRAATKVLRRSLRAVIEGPWGQIFDRPTSTPLDLNSPAVCIDVSRIPEGDTKLLAAVLMVCWSEGFGAAAAAHALADAGLAPPRTFEVVMDEIWRVLGAGEFMVDRVDALTRLNRPLGTGLIMCSHTIKDLAAFDSPAAQAKALGFFERARAKIIGPVGPEEIERLRAAVSITDTEKLLVTSWAAPRPPTDDHLDASGARETPPGTGCFLLKTGEADAPGIPFRMTFTPTERSRDIHNTNRRFAHLEKREAPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU77</accession>
    <name>A0A231GU77_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTH-type transcriptional regulator TtgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ttgR_5</name>
        <name evidence="7" type="ORF">B7C42_07748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40166">
        <property type="protein sequence ID" value="OXR40166"/>
        <property type="gene ID" value="B7C42_07748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="24358" checksum="41755B6563EB1A35" modified="2017-10-25" version="1">MAARTNKSVTQRAAGSGGAAAARTRRTQQERTAQAEQALLDAAESLFAQRGVDQTSLGDVGQLAGYSRGLVNHHFGSRATLVDELARRIQSQFVSDTESAMNVADTGIDAVEVLANLVQAYLAAIARHEQTSRAFFVMWGASIPSEATLRPVFATDDAHFRQGVEAILRAGQDNGSVDAAVDPAATAVTVIGMLRGIAAQYLITPDAIDLRAATHAAQRFLRQTLAPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV80</accession>
    <name>A0A231GV80_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40488">
        <property type="protein sequence ID" value="OXR40488"/>
        <property type="gene ID" value="B7C42_07426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011216840" evidence="2">
        <location>
            <begin position="30"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="40075" checksum="7C9CD0C546EB590E" modified="2017-10-25" version="1">MPARRIRKSARIGVGVLAVGLSAAACSGASDPDSATLRAGQVLTARPLTGAAALSGAASTRLITYVSDDAHGRPIVVSGTVAVPAGAPPKDGWPVLSWAHGTTGYADTCAPSADTADGPDHDYLGPVNRILDSWVAKGYAVVQTDYEGLGTPGGHPYINGTSEADTVVDIVRAARALDPSIGKRWVVAGHSQGGQATLFTAQAGAARAPELELKGAVSIAPGGVGLSGTVDYLRSNRPGAEAAEAFLPVILLGAHAAEPAIDPDALVTPQAAPLLTAGRTGCLAQIRAVPPVPPAQVFAPNADVGPLTRYLDEQDPSRVTPTVPTMIAQGTADAAVAKPGTDALVKTLCDRGVRIDYRVYDGQDHRGSVPASLADAQEFAARVMAGESTATSCGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV98</accession>
    <name>A0A231GV98_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042691.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40553">
        <property type="protein sequence ID" value="OXR40553"/>
        <property type="gene ID" value="B7C42_07362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="20515" checksum="6D37214B7F840DB9" modified="2017-10-25" version="1">MTETSRAAILLDVDGPLNPYPRPTHPPPRGYRPYVLQHSIIPAIPPIDQRVLLDAAVGSRLLDLAAVTDAELVWATAWEYEANTVLGPVLGLPPLEVIIFEDTGIRHREGHHGKLPTIDRWAGRRPLCWFDDEFQPADQGWAERRTATVAPTLLVPVDRHTGLTSDHLEVARAFLEPLRGPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVD1</accession>
    <name>A0A231GVD1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigJ_10</name>
        <name evidence="8" type="ORF">B7C42_07341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40532">
        <property type="protein sequence ID" value="OXR40532"/>
        <property type="gene ID" value="B7C42_07341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="109"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="33987" checksum="B05CF07D5874319E" modified="2017-10-25" version="1">MDTATVARFEASRNRLASLAYRLLGSAADAEDTVQDAFLRWQAADREFVEVPEAWLTKVVTNLALDRLRSAAARRERAVGAWMPEPLLDGDPMLGPAETVEQRESVTLAVLMLMERLSPIERAVYVLREAFSYSHAETADILDITESASQQYLHRARRRIAAAGTTSETDRASARRIVEAFVAAASSGRTERLVALLTADATGVSDGAGLGWAAKLIRYATPERIAGAVRAGFKPSPAKRKLAGGSPAIHAAVVNGCPAMLATLDDRVVGVLILEVRDGKIAGVRGIAARHRLGRLTEEWRRQDHDAPLIESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVG3</accession>
    <name>A0A231GVG3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4873 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064902000.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40620">
        <property type="protein sequence ID" value="OXR40620"/>
        <property type="gene ID" value="B7C42_07305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032371">
        <property type="entry name" value="DUF4873"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16170">
        <property type="entry name" value="DUF4873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4873" evidence="1">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12541" checksum="9653974666E09503" modified="2017-10-25" version="1">MNTHGPHDDSDFIGPATVIITSHEIDVQVELRGFFQPIDGRFCWYGRVRQNDAIDELLQGRRRSVVIRTSGGEAAATLGDRDFWGRYRIQGRGRPPYHVPSSLEEIEGTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVY1</accession>
    <name>A0A231GVY1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40787">
        <property type="protein sequence ID" value="OXR40787"/>
        <property type="gene ID" value="B7C42_07070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="28389" checksum="B6FB0C23AC002E43" modified="2017-10-25" version="1">MEAFYRPDPTDPALFHSTELTRGPWSPDAQHAGPPSALLGHVIERCEPRPGFRAGRVAVEILGPVPIAPLRAEARVVRPGRSVELIEATVATDRGPVLKANAWRLRVADPEVEVPADAVATGAYPGPDTVAHSGEFPSNQPVGFHTGIDYRFVAGSFQQPGPAVCWIKLRYPIVAGTTPSPLERTLAAADSGNGVSAVLDWERYLFINTDLTVTLHREPVGEWVCLDAVTYPERSGIGMAESRLYDEKGPVGRSTQTLLIGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW04</accession>
    <name>A0A231GW04_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40752">
        <property type="protein sequence ID" value="OXR40752"/>
        <property type="gene ID" value="B7C42_07176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="9316" checksum="5CEB02EFEB9915A7" modified="2017-10-25" version="1">MSEFRIDDIFRVSFRPNPIIVGRTDDMFSVGDQVELLKRDGSTVRGVLEGIEIHRSPSGQYSFVFSREISERAEPGDIVRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW60</accession>
    <name>A0A231GW60_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase</fullName>
            <ecNumber evidence="1">1.1.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hsdA_3</name>
        <name evidence="1" type="ORF">B7C42_07089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.50" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780109.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40805">
        <property type="protein sequence ID" value="OXR40805"/>
        <property type="gene ID" value="B7C42_07089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047042">
        <property type="term" value="F:androsterone dehydrogenase (B-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="27766" checksum="2291E3742DEDFC25" modified="2017-10-25" version="1">MGTIAVTGSASGIGAAVAAHLEKEGHRVIGVDLRDTEVTADLSTAEGRAHAVAEITRISAGRLDGFLPFAGVAAATGRPGGLVVSVNYFGAIALLEGLRPLLRESGNASVVLVSSNSTTTQPLWPVELADACLAGDEERARGIAESFGDLGAIQAYPATKAALAWYARTKSAEYIADGIRLNAIAPGIIDTPMTQEGSKDALTGEGMKQFLAMTPIGRPGRPEEIAELAAFLLSDKAGFFVGSVIFCDGGIDAAFRGKDWPAVWNPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWA2</accession>
    <name>A0A231GWA2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiosulfate sulfurtransferase GlpE</fullName>
            <ecNumber evidence="3">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpE_4</name>
        <name evidence="3" type="ORF">B7C42_07011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40876">
        <property type="protein sequence ID" value="OXR40876"/>
        <property type="gene ID" value="B7C42_07011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="162"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="298"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="380" mass="40557" checksum="210E5E9BB9FEA12B" modified="2017-10-25" version="1">MSTSSIGDSIETSNTGSQGDAEKLFGTIDSEVLRRWLADDDELAVLDIRPAQVVGYASPLFANNLPAERVAAEIDRYVPRARVRTVLVDGGDGVAESVARVLAAAGRTAVHVLAGGIPEWTRDGTDDLPTFDVPGQAFSLGIRDERKTPAVTAAELQALQDGGADVVVIDTRTLPEFTAGHVPGAVGVPGAELLLRFADVVPSPDTHVVVSCAGLPRAIIGAQTLIDAGVPNKVSYLHEGTKAWQQENFELETGATAVYGPADEAAREYAAQRVRAISAEDEFDRITADTARVWAADPDRTTYLLDVRTPEEFAREHLPGSINAEGGQLLGVAYRTIAVRGARVVLIDDLTAARASVVAHWLQRRGFDIALLLHDFRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWE5</accession>
    <name>A0A231GWE5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_10</name>
        <name evidence="4" type="ORF">B7C42_07033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40898">
        <property type="protein sequence ID" value="OXR40898"/>
        <property type="gene ID" value="B7C42_07033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="449" mass="48350" checksum="33930BF7E90F2C73" modified="2017-10-25" version="1">MSGPTSGFHLNLSLMTPGHFRQAWRLPHADPLAYLDIDYFQRLARIAEAAKIDAVFLGDGPALRGEIAEAPGTGIDPLVLLGSVAAVTEHLGVVITSSTTYNSPYNLARRFQALDHVTKGRAAVNIVTTGTPAAAANFGLDAHPARETRYQRAWEFLDVVTKLWDSWDADWLVADKASGRYADPDRIHRIDHEGEFFSVAGPLPVPPGPQGRPVVVQAGGSEGGLRLAGDFADVVFTVAQTRERAVAFREEIRRRAVAAGRGPDAVKVSLGVVVLVAATEEQARRRERELYDLLPIERLTANLLANLGLPAGSFGPDDPIAVGDLPESIPAETFSTGFSESARALIAAGPRTPREVIERGAGGSGHRLLVGTPEQVADDLQQWFDAGAADGFTIMPAETAVDLENFATGVVPILQRRGLFQRVYRDRTLRARLGLPVARRQRGEIAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXK5</accession>
    <name>A0A231GXK5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mch_3</name>
        <name evidence="6" type="ORF">B7C42_06693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41295">
        <property type="protein sequence ID" value="OXR41295"/>
        <property type="gene ID" value="B7C42_06693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16878" checksum="533842167F7051B6" modified="2017-10-25" version="1">MAGVWFDELSVGQRFEHAIRRTVTETDNVLFTAMTHNPALLHLDEEYMQGTQFGRRIVNSAFTLGLMVGISVGDTTLGTAVANLGWDEVRFPKPVFHGDTLHVVTEVLELRDSKSRPDQGIVVFLHQAFNQRDELVASCKRSGLQRRKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXQ5</accession>
    <name>A0A231GXQ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathionyl-hydroquinone reductase YqjG</fullName>
            <ecNumber evidence="4">1.8.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yqjG</name>
        <name evidence="4" type="ORF">B7C42_06533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41390">
        <property type="protein sequence ID" value="OXR41390"/>
        <property type="gene ID" value="B7C42_06533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="164"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="345" mass="38800" checksum="CB193ACFB630A60E" modified="2017-10-25" version="1">MDTSPTEHAGSNTATYVEPGEFKRDTNYITTRITADGRDGYPVEPQRYRLIAARACPWANRTLIVRRLLGLEQVISLGLCGPTHDKRSWTFDLDPGEVDPVLGIHFLRDAYLARDPEYPRGITVPAVVDVPTGQVATNDYPQITLDFSTEWTQFHRPGAPQLYPEPLRAEIDQVNRRVYTEVNNGVYRCGFAGSQDAYDAAYDRLFTALDWLSERLSEQRFLVGDTITEADVRLFTTLVRFDPVYHGHFKCNRNKLTELPVLWAYARDLFQTPGFGDTVDFTQIKRHYYVVHSDINPTGIVPKGPELSGWLTPHGREALGGKPFGDGTPPPPPLPAERVPAADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXS7</accession>
    <name>A0A231GXS7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41410">
        <property type="protein sequence ID" value="OXR41410"/>
        <property type="gene ID" value="B7C42_06553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="30090" checksum="D5DF931CB5E8353E" modified="2017-10-25" version="1">MRIELTTDPFEFHTRAGHCLARDPLRHTVIATMVRNGVAGAMTIEPVFAMVCDGDAVVGVALDTPGHGAYLGDIPAPALPGVAAALFDRDPAVVAVEGDPRSASEFAGHWQRLSGNAFRLQWTTRLYRLGELRLPAVPGIARRAGDADIDQCVRWAERMRREEDIGPDPRAVPDRIVAGQWWLWEDAGTPVSVVAHQRRAYGWTRIGPVYTPPEFRRRGYAAAATAQVSKVLRDSGSQVCLFADLANPTSNKIYQEIGFEPVGDFPRFVFDASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXZ0</accession>
    <name>A0A231GXZ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41469">
        <property type="protein sequence ID" value="OXR41469"/>
        <property type="gene ID" value="B7C42_06361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="45"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="43049" checksum="E8A4E11AE163CB78" modified="2017-10-25" version="1">MTTSASTTGTTRIDAAGELLTLLNESTTEPASDIQLEALTVAVAADLPVLLWGEPGIGKTAALTQLADSLDLPLTTVIASVHEPSDFSGLPVVGDDPAAQGVPLAPPDWAVRLVRAGRGLLFLDELSTAPPAVQAALLRLVLERRIGALRLPAGVRIVAAANPRSSAADGWELSAPLANRFVHLTWTHDPDVVVRGLGGVWPRAGLPTLDPEMFPAAVSFARRAVCGLLAARPALVHRMPSGEARRGGAWPSPRTWEMTLRLIAFATAAGAGREALSLLVRGTVGDGPGFELLTSIDRMELPDPEHLLADPDTADLPERGDLRQAVLDGVVAAVRRKPDKSRWDAAWALLAKAVETGAPDLVVVPATTLAALRRDHWEIPAAIERLAGMVEVSRTADRAADRVAAQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY11</accession>
    <name>A0A231GY11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DesR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">desR_2</name>
        <name evidence="5" type="ORF">B7C42_06406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780920.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41514">
        <property type="protein sequence ID" value="OXR41514"/>
        <property type="gene ID" value="B7C42_06406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="23849" checksum="2CC66E1EA881F4D5" modified="2017-10-25" version="1">MQENVAAGNPYRIGVVEDHQVTIAGLRQILAGEPTVTIAATAASVTELLDATTDLALVVLDLRLPDGSSPATNIEHLRAAGIETLVFTSGDEPFLVRAAARAGVLGVVRKSERDEVVAAAVRDAAAGRQVPTTDWAVAIDSDENFATVTLSPRQRDVLALYASGEPAARVARLTGLTEDTVNAYLARIRQKYAEAGRPSRTKTELFKRALEDGWLPIPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ41</accession>
    <name>A0A231GZ41_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41842">
        <property type="protein sequence ID" value="OXR41842"/>
        <property type="gene ID" value="B7C42_06184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="487" mass="51665" checksum="D4900A56983839C0" modified="2017-10-25" version="1">MDVVVRTACGAVRGEARQGYSVFLAIPYAAPLVGIRRFQAPAPPQRWSGVRDARRFGSSVPQPILWHPGDDPECLTVNVWTPDAGTSGMPVVVWLHGGACMGGTAVTADFDGAAFAAAGVVLVTMNYRVGYEGFGWVDDAPCNRGVLDQIAALGWVHDNIAAFGGNPDAVTLIGQSAGASSVVGLMAGDRAPDLFRRGIAQSPGKIFVPADEARAVSAMITSQLGVRPTAGALAELPPEAIHAVQMEPVAVMAAEPGRWTHPNAPYSMIVDGELFDAPPWFDHRASGANRELVCGFTTDEARMFTADVDLSGSDPVETARSCGLDADAARTFRTGNPGSTDEELHALILSDALFRMPALWCAEAAAEAGTDTYLYEFAWPSPARDGALRACHGLDVPFTFDTPRGPLAAQLIGPEIPPDFADLSAAMRDAFLAFAATGDPGWPRFETTERIRRIWATPPELGGDTLATSRRIWQRARVPGRPSSADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ84</accession>
    <name>A0A231GZ84_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41885">
        <property type="protein sequence ID" value="OXR41885"/>
        <property type="gene ID" value="B7C42_05869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013076440" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="35528" checksum="E30CF7157328DA70" modified="2017-10-25" version="1">MKTTTQWKTGAVAAALGCSLMVTSACSVGPDDLPSVRGGVGAGYQLDLQFVSTMNLPTGADVMMDGLRVGEVENLTASGKFVKVSTHVKDGTKVPADVRAVIRQNTLLGDTYIALDHGPVVQGPYLGPGATVTVDHTSSPPQLEDTMAVLAYFVNGGSIQKIEDAMTGINTVMPQPRDVQRLASVVAGDMRDLAGDTHEIDRMLNGFQATGGAIDAKGQTLATLFGQQTEHYWRRTAVSIVSYISQILPSVGSVYEGGLWLVPLFNSLAETGGIGRDIWDRAPADTAKLSEFLRTTLLPFVQDPSVNIRSIDTDHGDRIVADVENLLRMLGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZF8</accession>
    <name>A0A231GZF8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chondramide synthase cmdD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cmdD_3</name>
        <name evidence="2" type="ORF">B7C42_05983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042724.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41999">
        <property type="protein sequence ID" value="OXR41999"/>
        <property type="gene ID" value="B7C42_05983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="114" mass="11697" checksum="DA6D6FE257B3C471" modified="2017-10-25" version="1">MPDAPIVTGAAASRGVVAGPVRLVHSVDDFDAVRPGDVIVCRTTDPSWTALFGVAAAVVTETGGMLSHAAIVAREFGIPAVVAAEGAMRTLADHRIISVDGTKGHVHAVRSTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZZ9</accession>
    <name>A0A231GZZ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">3-methylcatechol 2,3-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">todE</name>
        <name evidence="9" type="ORF">B7C42_05792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778515.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42193">
        <property type="protein sequence ID" value="OXR42193"/>
        <property type="gene ID" value="B7C42_05792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 7 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="143"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="34746" checksum="CEDBBC4F0A6DE618" modified="2017-10-25" version="1">MTGVKELAYVVYEASDLAAWRHFACDLLGMQLAAEDADSLALRTDQRAFRWRIERGAADDLAVSGYEVDSEESLDRLVATLRAAGVEVSEGDAALADSRHVDRVVLTTDPMGNRIELVTGFADAPTPFRSEVLLGSFVTGTGGAGHQVLLARGVERADYMAFYEGLLGFRVSDTIVEELAPGVFADLIFLHCNPRHHSVAFGAMPHPKRTHHFMIEVSDIRDVGTAYDRCLDAAQPFEMTLGMHPNDNMFSFYVRTPSGFSVEFGWGGLLIDDDTWQVRTLDRLHSWGHRAPEVVHDLLGRAPFTNIAHEEMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H042</accession>
    <name>A0A231H042_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779714.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42224">
        <property type="protein sequence ID" value="OXR42224"/>
        <property type="gene ID" value="B7C42_05823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="16413" checksum="08DF37390C8C3D71" modified="2017-10-25" version="1">MESSGFADWPDYRVDVRRIRNLVRVLHNDRVLAETTASLLVAEQDHGIVFYIPVADIRFDLLTLDEQLTSRCPFKGWARYWHPTGSDEPIAWEYHDPYPEVALIRDHIGFYQDRVRLEIGVADPAVSGLRHRPESARTPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H045</accession>
    <name>A0A231H045_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42233">
        <property type="protein sequence ID" value="OXR42233"/>
        <property type="gene ID" value="B7C42_05832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="16644" checksum="9A34B94B00492270" modified="2017-10-25" version="1">MQKEQRPAVEGWFTADDGTVRLQGSRCDVCGTPYFPRNTLACRNPQCASPKDGSELVEYLFSTRGRIWSYADARYKPPAPYVSPDPFEPYVVAAVELEEEQMVILGQVVRGLTVDDLAVGMPVELTLGVLYEDEEAEHTVWMWRPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H093</accession>
    <name>A0A231H093_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cstA</name>
        <name evidence="11" type="ORF">B7C42_05468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42269">
        <property type="protein sequence ID" value="OXR42269"/>
        <property type="gene ID" value="B7C42_05468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="54"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="498"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="764" mass="81523" checksum="A086794F52801F82" modified="2017-10-25" version="1">MATIEYLRTEPELPPVGIVDRRPITPAKKAIFAAVAVFGAVAWAILAVARGENVNAVWIVIAAVCTYIIAYQFYARLIEWKITKPRDDTATPAEELENGTDYMPMDRRVLFGHHFAAIAGAGPLVGPVLAAQMGYLPGTLWIVIGVVLAGAVQDYLVLWASVKRRGRSLGQMARDELGVVGGVAALIAVLVIMVILLAVLGIVVVNALAATKGADGQLHGGSPWGVFSISMTIPIALLMGLYLRYVRPGKVGEISVVGFVLLLLAIVSGRWVSESGWGRDLFTLSGTTIAWMLIIYGFIASVLPVWLLLAPRDYLSTFMKVGTIVLLALGVVITMPVLHAPAVSQFAGNSKGPAFAGSLFPFLFITIACGALSGFHALVSSGTTPKLLEKQSQARMIGYGGMLMESFVAVMAIIAASILDQHLYFAMNTGGLTSAQAAADKVNALGLGGTPITANELNQAAHDVGEQAIYSRTGGAPTLAVGMAEVMHNFIGGAAMKSFWYHFAIMFEALFILTTIDAGTRVARFMLSDTLGNLGGPARKFKDPSWRPGAWLCTFVVVAAWGSVLLMGVTDPLGGIYTLYPLFGIANQLLAAVALTVVLVIVMKKRLWKWAWIPALPLIWDLIVTMTASWQKIFSGDKNIGYWTQHRIYSDARDAGKVLAPAKSMADMDKVVRNTFIQGSLSIIFAVLVLIVAVVGVIVCVQAVRRGGGATTETPEVPSKIFGPSGFLTTKAEKEVQREWEELERTGAVKVPGAAHASTPEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0F1</accession>
    <name>A0A231H0F1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42319">
        <property type="protein sequence ID" value="OXR42319"/>
        <property type="gene ID" value="B7C42_05518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="8809" checksum="2C401AB2CD23BA37" modified="2017-10-25" version="1">MTRADMTRAGTSPPDRAVDTERRIALVDLLDRVLAGGVIITGDIRLAIADVDLVQISLRALISSISTLFPPALSASPDKHADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0L2</accession>
    <name>A0A231H0L2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-[acyl-carrier-protein] desaturase DesA1</fullName>
            <ecNumber evidence="8">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">desA1_4</name>
        <name evidence="8" type="ORF">B7C42_05490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42291">
        <property type="protein sequence ID" value="OXR42291"/>
        <property type="gene ID" value="B7C42_05490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="32270" checksum="8C6F4329273A2840" modified="2017-10-25" version="1">MVQTQLTDRELLESLADAVEDNLRRHTELAQVWQPHEYVPFSDGRNFGFLGGVDWDPEQAALGEVATVALTVSVLIADNLPSYHRELGKHLRTGPWWRWVGRWTAEENRHEILIRNYLMVTRAVDPVELERARMEHMTTGFRRPPLHLLDVLALCAFEESASAVRHRNIAALQENSMVTAIADRIALDDELQSAFFGNLVAAALELVPDQAMRAIADRIAEFRVPELTLRDGRNSTEVLAEAGIYEPKRAGELVFTPLLERWNIFSRTDFGTAGEAARAELGHLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0P8</accession>
    <name>A0A231H0P8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42341">
        <property type="protein sequence ID" value="OXR42341"/>
        <property type="gene ID" value="B7C42_05540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11967" checksum="F6EC2B3A56A69275" modified="2017-10-25" version="1">MPAYAIAHLHDVDVNAEIVEYLRRIDGTLAPFGGKFIVHGGRQMVAEGPADGVMIVIEFPDYDAAQAWYASPEYLEILPLRLNNAAGVAILAEHCGDNHVATDVLPAELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1B3</accession>
    <name>A0A231H1B3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemin import ATP-binding protein HmuV</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hmuV</name>
        <name evidence="5" type="ORF">B7C42_05410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778205.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42632">
        <property type="protein sequence ID" value="OXR42632"/>
        <property type="gene ID" value="B7C42_05410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="33"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="29897" checksum="6B9E4277609FE63E" modified="2017-10-25" version="1">MSGTGTARVRALIRRLRPAQGIPQPAPRGAVTLRARGIDIARGGRAVLEAVDIDVVAGQILALVGPNGAGKSTLLAALSGELEPASGTVELDGRPVADWTPTDMARRRAVLPQNHTVGFPFTVREVVAMGRSPWARTPRQDVDDQAIAAALAATDIEHLAARPFPALSGGERARAALARVLAQDTETLLLDEPTAALDLGHQEQVLRLAAARAAEGAAVVVVLHDLGLAAAYADRVAVLDGGRLAAVGRPRDILTTDLLTTVYRHPVEVIDHPVTGAQLILPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1F2</accession>
    <name>A0A231H1F2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subtilase-type protease inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sti</name>
        <name evidence="5" type="ORF">B7C42_05020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42684">
        <property type="protein sequence ID" value="OXR42684"/>
        <property type="gene ID" value="B7C42_05020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012149933" evidence="3">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="4">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="12832" checksum="F8F8BF6A9BEE49C6" modified="2017-10-25" version="1">MKVTTRGLIGAACAAAVLMPASSATAHDAATQLIFTRTEPDRSPRTVTLTCDPIGGSHRGAAAACAYLADAELTLPDSDSGARCFRYYPVELRAHGTVRGTPVSIEHTYGCVVPDLPAPWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H228</accession>
    <name>A0A231H228_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42901">
        <property type="protein sequence ID" value="OXR42901"/>
        <property type="gene ID" value="B7C42_04787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="17212" checksum="B0BEC604D5E0F8AA" modified="2017-10-25" version="1">MPTSMLDELYERAEKDCVALRIGVIIDRGGQVLLLERDDSGPVKATLKLPGTTVEPGEPLDTAVSRGVATETGLLVTGIRSHVGYFDYLSPIGKPVRRLHFAVDVAATYPIRLSVHSAYTWAPLDGDLRVTPSIRRILQDYRELARARNPLTETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H229</accession>
    <name>A0A231H229_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkane 1-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.15.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alkB_3</name>
        <name evidence="10" type="ORF">B7C42_04782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.3" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42896">
        <property type="protein sequence ID" value="OXR42896"/>
        <property type="gene ID" value="B7C42_04782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018685">
        <property type="term" value="F:alkane 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052869">
        <property type="term" value="F:arachidonic acid omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03512">
        <property type="entry name" value="Alkane-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033885">
        <property type="entry name" value="AlkB/XylM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38674">
        <property type="entry name" value="PTHR38674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="117"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="370" mass="42216" checksum="7622D42F0308058E" modified="2017-10-25" version="1">MTVFGRAQVRDHKRYLWVLSSLGAAGALLPGQLVTFTRLELFWWIGPIAVLGVIPLLDIAMGVDSRNPREEDYDALTNDRYYRWCVYAFLPIQFIGLAIAGFMWSRPELKLIDKLGLAATMGFVSGLGINAAHELGHRVEHLERWLAKIALAQSGYGHFYVEHNRGHHVRVATPEDPASARFGESLWKFLPRSALGGFRSALALERERLSRRGKRWFSRHNNLLQAWSMSAVLFGALILAYGPVIIPFLILQAVVGIILLETVNYIEHYGLLRRRRADGRYARCSPRDSWNSDRLVTNVFLFHLQRHSDHHANPGRRYQTLRTSEESPQLPYGYATMIVLALIPPLWRKVMDPRLLAHYDGDMTLVNKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2L3</accession>
    <name>A0A231H2L3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Malate synthase G</fullName>
            <ecNumber evidence="10 12">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">glcB</name>
        <name evidence="13" type="ORF">B7C42_04963</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 12">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10 12">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the malate synthase family. GlcB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="10 12"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777951.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43077">
        <property type="protein sequence ID" value="OXR43077"/>
        <property type="gene ID" value="B7C42_04963"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00728">
        <property type="entry name" value="malate_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00641">
        <property type="entry name" value="Malate_synth_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006253">
        <property type="entry name" value="Malate_synthG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42739">
        <property type="entry name" value="PTHR42739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01345">
        <property type="entry name" value="malate_syn_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 12" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0558">Oxidation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="10">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyoxylate binding" evidence="10">
        <location>
            <begin position="457"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 11">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine sulfenic acid (-SOH)" evidence="10">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601465-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR43077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="727" mass="79073" checksum="480DC29E361A58AE" modified="2017-10-25" version="1">MTERIQVGGLQVAKVLHDFVENEALPGSGVDSAAFWTGAESVINDLAPRNRALLAERDEIQGKLDAWHAENPGAGYDKAAYKRFLTEIGYLREQPAPFTIDTQNVDDEIATTAGPQLVVPVSNARFAINAANARWGSLYDALYGTDAISEANGAEKGTGYNKVRGDKVIEWARNFLDDAVPLITGSHVGSKAYKIVDGELEVTLEDGTDIGLADSSALVGYLGDPSAPSSILLRHNGLHIDIQIDPESPIGKTDDAGVKDVVLESAVTTIMDFEDSVAAVDAEDKVLCYHNWLGLMKGDLAEEVSKGGKTFTRTMNPDRVYTGLDGNDVTLHGRSLLFVRNVGHLMTSDAILDAEGNEVPEGILDGLITSLIAVHSLNGNARVSNSRTGSVYIVKPKMHGPDEVAFANELFSRVEDVLGLARNTLKVGIMDEERRTTVNLAACIAAAKDRVVFINTGFLDRTGDEIHTSMEAGAMIRKAEMKKQQWILAYEDWNVDNGLADGLPHKAQIGKGMWAMPDLMHDMLEQKIGHPRAGATTAWVPSPTAATLHATHYHLVDVFKRQAEIAKGGPRATVDQILEIPLATDTNWSAEEIRNELDNNSQSILGYVVRWIDHGVGCSKVPDINDVALMEDRATLRISSQLMANWLRHGIVTEQQIVESLERMAPVVDRQNAGDPAYKPMAPDFSGSIAFQAAKELILEGTRQPNGYTEPILHRRRREAKALAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H373</accession>
    <name>A0A231H373_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_19</name>
        <name evidence="9" type="ORF">B7C42_04690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43268">
        <property type="protein sequence ID" value="OXR43268"/>
        <property type="gene ID" value="B7C42_04690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="117"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="223"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="44837" checksum="91D716065F164607" modified="2017-10-25" version="1">MTKAEGPPTTPHTLAEEVRSWLADNWHGTDDSAWRARVVESGWAAPTWPSDSFGRGLSRPDGKTVRDEFRAAGARGAAVEHRGFTALAGNTIVEFGSAQMKRDILPKLLSGEWSRGCLLYSEPSNGSDLAGLQTRADQHDDVFIVNGQKIWTTGGHEADCALLLARTDWDRPKHAGISFFIIPMDLPGIEVRPIKQMTGESDFNEVFLTDVRVPASALIGELNDGWRVLQTALKEERRTMGFEIGAPTRDDNARPAIFTASDDLVAAARAAGKLGDEAVRQEIMRIHSWRLVNDWNAVRAKKQIEAGGGSSLASLGKLAKSRILHSAWGLRFRLLGARGLLYDESDKQAYEVDHQMMWSFINSIGGGTDQIQRNIIGERILGLPKGHEPDRGVPFRDVRKGGTAVPDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3F3</accession>
    <name>A0A231H3F3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prpB</name>
        <name evidence="4" type="ORF">B7C42_04246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43379">
        <property type="protein sequence ID" value="OXR43379"/>
        <property type="gene ID" value="B7C42_04246"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="304" mass="32498" checksum="B949B01AA5E10909" modified="2017-10-25" version="1">MTGLLAAATPAADKRVAFRAGLASATIQRFPGAFNPLVAKLIQEIGFEGVYVSGAVVSAELGLPDIGLTTLTEVAGRGAQVARVTDLPVLIDADTGFGEPMNAARTVTLLEDAGLAGCHLEDQVNPKRCGHLDGKAVVPTDEMVRRLRAAVSARRDPNFVICARTDAAGIEGIDAAIDRARAYADAGADLIFTEALGGAADFEKFRAAVSIPLLANMTEFGKSDLLPARTLESIGYNAVIYPVSTLRLAMWAAETGLRAIHETGTQAGLLDRMQHRSRLYDLLQYERYNEFDSDIFTFTLGRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M9</accession>
    <name>A0A231H3M9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dauA_1</name>
        <name evidence="15" type="ORF">B7C42_04321</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43454">
        <property type="protein sequence ID" value="OXR43454"/>
        <property type="gene ID" value="B7C42_04321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="14">
        <location>
            <begin position="27"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR43454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="746" mass="77287" checksum="C9DA4F3DAA71AFCD" modified="2017-10-25" version="1">MSTDTVATPRPSAPPGPSWSDRMNSVLRHDLPASVVVFLVALPLSIGIAVATGAPVAAGLIAAAVGGIVVGSLGGSVLQVSGPAAGLTVVMAETINQFGWKTTCFITVCAGALQIVFGLSRIARAALAIAPVVVHAMLAGIGITIALQQVHVLLGGSSQSSAWENVAELPNQLLHLSGIDVVIGGLVIAIMLGWRWVPAKIRVVPGPLVAIVVATALSLVLPGNPARITMSGSLFDAVGLPDMPSGNWSGVALAVLTVALIASVESLLSAVAVDKMHNGPRTNFDRELMAQGAANVTSGMIGGLPVTGVIVRSATNVTAGARSRASALLHGVWVLLFSIALVGVVEQIPKSALAGLLVMIGIQLVKLAHIKIAHRTGELVIYAVTIAAVVFLNLLEGVLIGLVVAFALLLWRVVRVSVEAAPVEGTDRWLVSVDGTCTFLALPKLTGQLAKVPEGVDVLVELTVDFLDHAAYDAVHSWAQQHESTGGTVEFVEIGPARMADAAERPPRRARARGLLDDVLGPWRSEGGNPVAAGVAAYHRSHAHVMRPHLDELRHGQDPDSFFLTCSDSRIVPNVITNSGPGDLFTVRNIGNLIPARGTDVSVDAALSFALHNLSVRNVVVCGHSGCGAMNALLSDRSAGPDIDDWLAHGAEALQRYRGGHPVAAAAAAAGYGPADQLSMVNVAVQLETLRQHPVVARAVDERGVALSGLFFDIGTARVLEVTTTGIAEITDAERPGIPARNPTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3N2</accession>
    <name>A0A231H3N2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ymdB</name>
        <name evidence="2" type="ORF">B7C42_04345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43478">
        <property type="protein sequence ID" value="OXR43478"/>
        <property type="gene ID" value="B7C42_04345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="18353" checksum="A8C2DB16006417A4" modified="2017-10-25" version="1">MGGMAEIVLVRGDITEQDVDAVVNAANSRLLGGGGVDGAIHRRGGPEILAACKQLRATTYPDGLPTGAAVATTAGNLPARWVIHTVGPVWAAKQDRSGLLASCYRESLRVADEVGARTIAFPAISTGVYGWPLDDGARIALDTVRAARADANEIRFVLFDETAHRIFESALAATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3T3</accession>
    <name>A0A231H3T3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43422">
        <property type="protein sequence ID" value="OXR43422"/>
        <property type="gene ID" value="B7C42_04289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="38171" checksum="40E2B7418E97A277" modified="2017-10-25" version="1">MLACTRSGREREALIQAAKMAGAAVAAWTIARAAIPAPQSFMAPYAAVFLMTTTVYRSLTGAAQQTCALLAGLAVAYLTTLVFRQPMLTLGVAVFAGMIVGQWHRFGTSGIWTGVTALLMVCYGTAQNLTYLAYWMAEILLGSAIGVAVNMIVLPPMHLRRTREAVDALAGELRELLASIAAGLTEHVDLPTAAHWQHQARLLDATVRRADDALGQGRESLRWNPRWLVRRRRDWHPAVSESPFRTLSEVSEQVKRLTEAVATGADYDEFGEVFAPRLAHLVTILADAVACLDATHAHPARLDAYLDELRTAHADTAAAVRDLSERHIPGHAQQAALLAVVRSMYALDAGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H424</accession>
    <name>A0A231H424_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042712.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43605">
        <property type="protein sequence ID" value="OXR43605"/>
        <property type="gene ID" value="B7C42_04473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="280" mass="30500" checksum="88E5A0C8AA99FB16" modified="2017-10-25" version="1">MEPVTGSHRPHADPVAPPGIDVTTPHPARRYDYWLGGKDNFEADRASAEAVAEAFPSVQISALENRAFLHRVVGYLSAEVGIRQFLDLGAGLPTAGNVHEIAQAAAPESRIVYVDNDPIVALHARSLLDSAPEGATAYLEADAREPEKILTHPDLLATLDLSQPVALMMLAVVHFFTDEDRPYDMVRQWTDALAPGSYLVMSHATSDHLSEEDLADSEQANKRSGIPFQLRSTAEFSRFFTGLELVEPGIGSIINWPTESHRAHPRPEAVSMLGAVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H558</accession>
    <name>A0A231H558_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44039">
        <property type="protein sequence ID" value="OXR44039"/>
        <property type="gene ID" value="B7C42_03595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="29" mass="3182" checksum="9D3953E06884BF7C" modified="2017-10-25" version="1">MVVAVMAVVVAAALLCSCMLVLRRRRHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5B2</accession>
    <name>A0A231H5B2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44035">
        <property type="protein sequence ID" value="OXR44035"/>
        <property type="gene ID" value="B7C42_03591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="22028" checksum="C7717DEB13B674C4" modified="2017-10-25" version="1">MTGTWTALNPTSGSSLLANFGALAVLVGTFAESGLLVVGFFLPGDTLIFPAGILCAGGSHSGPHLVLWQVLLCAAIGSIVGAQAGYTFGKHGGRAVLQRTSNSRLHTVVARGERWLDRYGARRAIVIGRFVPMVRTVISPVAGVLDVPTRTFTLWQIVAAIVWSQSLVLLGYWLGASVPNVDKYLLPAVAVIVVVSMLPLLGQLRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5N5</accession>
    <name>A0A231H5N5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777391.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44117">
        <property type="protein sequence ID" value="OXR44117"/>
        <property type="gene ID" value="B7C42_03674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="25349" checksum="5CC0AD41DAD5801A" modified="2017-10-25" version="1">MPESTHTPRRTRRRRLWSVALLALLLAPLLTGCLRVQVSMGVSSNDRVSGHLVAAVIPANDKDKGPELKAPETLATKIRVEPYSQDGYVGSQVYFDDLTFGEVQQLGALSDQTQGMFNLQFIRTGDKVTLSGRVDLKSVPPQGSDVQFTVAFPARVATTNGTRQGDSTVSWKLPAGDVSTVKAEVSYADPNTRSFAGWAGIVGGITLAVAAMVAVLAYLNRNPTPPWRPRVKQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5W8</accession>
    <name>A0A231H5W8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional activator PmfR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pmfR</name>
        <name evidence="5" type="ORF">B7C42_03192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44403">
        <property type="protein sequence ID" value="OXR44403"/>
        <property type="gene ID" value="B7C42_03192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="182"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="411"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="473" mass="50760" checksum="626E73A10BEE40FE" modified="2017-10-25" version="1">MATAPSDVAVRQWMADFVAETLRGETLEQMVARLDAQIIGRVPELTDRDLRRDLESSTRAHALAVLSGLTQDAMEYAIPEQAHAFARTLARRGYDLRLLLRVYHAGQEAAIDYMTEVIDERRLPEQFERSALIRLFERSTRWVNTSVEALTDTYMQERERGLRAALNQRTEIVRTLLSGEDVDADYASARLGFRLAQRQVAIVLWTDSAARGAGALLSAAADGFARAGFDLPGTGDGPREGPDAVTGTGDGIAGSDSVVGDRGVVGDRGADDRLTAGSDELGRLERTATRLATALGGAGVLTVPAGSAALWAWLAADAEAVAAVAADIVAAPIRLTLGSSATGVAGFRQSHRDAIAARQVAERAAVDLGRVLPYARVEPAYLAGADVAAMRALIRRELGPLAAPDANSARLRETLLAYLSCHRSPEGAAARLGVHKNTVRYRIQRIEETLGRRIEECGLRLELALECVAVYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H619</accession>
    <name>A0A231H619_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase IV</fullName>
            <shortName evidence="13">Pol IV</shortName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">dinB1</name>
        <name evidence="13" type="synonym">dinB</name>
        <name evidence="16" type="ORF">B7C42_03705</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44146">
        <property type="protein sequence ID" value="OXR44146"/>
        <property type="gene ID" value="B7C42_03705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 13" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="15">
        <location>
            <begin position="64"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="13">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR44146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="510" mass="53613" checksum="E0E58DF8684210B0" modified="2017-10-25" version="1">MSVPARRFPGMHSVPDAATGGLVPGQRASAGVDAGAGGGSAVHLHAQEPDSNFGADTVAARRWVLHIDMDAFFASVEQLTRPTLRGRPVLVGGMGGRGVVAGASYEARVFGARSAMPMHQARRLVGVTAVVIPPRGVVYGEVSGQVFETLRSWIPVLETLSFDEAFGEPAELAGANTAQVREFCEQLRQSVRERTGLVASVGAGTGKQLAKIASGLAKPDGVRVISPAEQQALLAGLPVRKLWGIGPVAEHRLRSVGIETVGAFAALPEPEAASLLGGSVGAALHRLARGIDERPVAERAEAKQISAETTYETDIVTLAQLRPAIEAMAEAAHRRLLRDGRAARTVVLKLKKSDMSIVTRSLTLPYATTDPATLTAAAQRSAIDPVELGSIRLVGVGFGGLSAVRQESLFPELDRDAGAVGDAVFEEPIAAAAPADEPVVPPPTRSYTTEFWYPGRDVGHPRYGHGWVQGSGHGRVTVRFETRSTGPGPAYTFAADDDDLTPADPLLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H686</accession>
    <name>A0A231H686_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44348">
        <property type="protein sequence ID" value="OXR44348"/>
        <property type="gene ID" value="B7C42_03909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="21081" checksum="2C8D10109230E247" modified="2017-10-25" version="1">MEPLAAARRLLGATMRSGPVAVRIVEVEAYGGDPAGPWHDPAAHSGRGRTPRNAVMFGPPGMLYVYFSYGMHTCVNVTSGPDGVASAVLLRAGEVIEGHEVARSRRRAARTEADLARGPGNFGSALGITLSDYGTALFDPAAPIRLELGPEITDSAAIGVGPRVGVSLAADRPWRLWLRDSPAVSVYRRSPRAPEVGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6N4</accession>
    <name>A0A231H6N4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fatty acid metabolism regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadR_4</name>
        <name evidence="6" type="ORF">B7C42_03297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775891.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44508">
        <property type="protein sequence ID" value="OXR44508"/>
        <property type="gene ID" value="B7C42_03297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="211" mass="24110" checksum="E70ACD32491D9D36" modified="2017-10-25" version="1">MPKSSVNSAPTPVDNLTPRGRKTRDALLDAARKVFETVGFLDTRVEQISEEAGVSYGTFYRYFESKDHVFGELSTRLFEDMHRREPAPAQLSPAARLIAANRSYYAAYRRNARMMAIVEQVATFNEEFRQLRHEHRRRLIDRTAQAIARWQREGLVRASLDPELAARAMSAMVDHTLYLWLIQGEDADEHALLETLDQMSVSALGLDPDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H756</accession>
    <name>A0A231H756_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011207082.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44556">
        <property type="protein sequence ID" value="OXR44556"/>
        <property type="gene ID" value="B7C42_03345"/>
    </dbReference>
    <dbReference type="GeneID" id="66718690"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="80" mass="9039" checksum="1770DA6A033D21FF" modified="2017-10-25" version="1">MSTNPFDDEDGRFFVLVNDEEQHSLWPAFAEVPAGWRVVFGEDSRAACVEYVEKNWTDMRPKSLRDAMAADDAARQGAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7G8</accession>
    <name>A0A231H7G8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44788">
        <property type="protein sequence ID" value="OXR44788"/>
        <property type="gene ID" value="B7C42_02742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="31" mass="3377" checksum="C0EF0170B8F98CD9" modified="2017-10-25" version="1">MSSIVFDYLLPLVGPEQAAYWAQILVINPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H835</accession>
    <name>A0A231H835_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784223.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44952">
        <property type="protein sequence ID" value="OXR44952"/>
        <property type="gene ID" value="B7C42_02909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="57"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="35698" checksum="0EC2299827EDA7A5" modified="2017-10-25" version="1">MASADPEFYREQQAWRDLQQFLPQRLRLGESTAPDEEFWEWRGHRVHLDRYRDASAPAKIVLHHGVGTNGRQMSLIAGAPLARRGFETVALDNLGYGLTRVAPGTVPTYDDWVDLVVDFLAYEQTRDDRPIVLYGLSAGGLLTYHVAAKAPKGTLRGIVGMTFLDQSDQRVRDETAHDIVSSRIGVPLMRLAARTPAGRLRFPMTLASKMSALVNDKAALAVMTRDRTSAGNRVSIRFLTSYVGYRPAIEPAQFDACPILLTQPAEDRWSPLHLSRPVLAPITAVPVRTVMLDNAGHYPLEEPGLTQMHDAITEFVSDTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H850</accession>
    <name>A0A231H850_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779966.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45018">
        <property type="protein sequence ID" value="OXR45018"/>
        <property type="gene ID" value="B7C42_02975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="499" mass="53417" checksum="AAC0901BFA7D7324" modified="2017-10-25" version="1">MNQATAVTLSWILAAILILTIAGALYAAYYASQQRARARSAEAELRAHEDELEHFTSTTMGLVADSVRRAESTVELPAIDRGGSRFAQLLQRLTERYADDLHRVAAETHERTSHELEYEKQQAISATEASIREQVENASREATSAAVRAFGTSVVSLGADVGQVVSAALRQHRGDDVYETLIRIDHSVQQMIRQAQSYVIVCGGLPGRRWPQQSLTDIVGGAIGRVRDFTRIRPQQLDRVIISRAVEPLVHTLATLLDNALRYSPPTSFVDVTFQEGHHGLTVIIDDAGVRMNPEQMEEARQVLAGERTVDIHQLGPTPRVGFPGIAALARRYGFTVYIDGPNIYGGMRAMVYVPEGLLAARPDNLESVTAPPISTPIEVAAAPAAVASGNVAPAPVSPAPVSLAPAPAAPVAEAEPLPAADPTPTGQSSTVHEITPGGLPRRRRRSVALPASARGPRTDTGQPHTDTGLPRVDIAEAWQTGSTSGRAAAHDNSEGMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8A0</accession>
    <name>A0A231H8A0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azoB_5</name>
        <name evidence="2" type="ORF">B7C42_03036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45079">
        <property type="protein sequence ID" value="OXR45079"/>
        <property type="gene ID" value="B7C42_03036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="29690" checksum="9A799D21C261A3BF" modified="2017-10-25" version="1">MILVTGSTGTVGRAVIDHLLAAGESVRALTRRPDAAALPPGVEVIGGDPGRPDTLPSALRGVSRIFLLSSGPDLARHDRTVATAAAEAGVERIVKLSSGRAGDTEATDPIPAWHRAGERAVVDSGLAWTILRPLGFMSNALHWAPTVREHDTVYAPYGHGRIAVIDPSDIAAVAAAALAEPGHDARIHTLSGPQALTPGEQTDILSEVLRRPLRYVSIEPAQAHAALLGAGVDEVMADAIMALRATALDSFTSVIHPGVQQITGRPARTFREWALDHRADFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8E3</accession>
    <name>A0A231H8E3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45141">
        <property type="protein sequence ID" value="OXR45141"/>
        <property type="gene ID" value="B7C42_03098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="181"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="35448" checksum="61383512A2329D81" modified="2017-10-25" version="1">MLYRDGVPTTRTDDGILALDNVDRALIARLRRDGRESSRSLAVALAVNEATVAGRLRRMEEAAIMRVVAVTDMRLFGHCEFAIAQIHTSGRPLNEVASDLAALPEAVSVTTCTGRCDAIVPIMGRDKSHLGELFGSVLPGVEGVEKVRGSMALDVVKYDSSWALLSADPGSIPQTEPGETVDALDLDIIHILQLAARRSNRSIATELGVSEGTVRSRIKRMLAQRIFRIQAVSDVVAFGLGAHAFVGIRTHAGAVDIVAKALAAREDVAQLTRTLGDFDLMAVLVTSNREVLANAVLHEISQLPGLRNTETFDTCATLKHTYAWTWMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8E4</accession>
    <name>A0A231H8E4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vitamin B12-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">btuF_1</name>
        <name evidence="1" type="ORF">B7C42_02339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45214">
        <property type="protein sequence ID" value="OXR45214"/>
        <property type="gene ID" value="B7C42_02339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="28276" checksum="1973EF9E9C6B5075" modified="2017-10-25" version="1">MVPEDPVDDLDAAVALRRPVRRVVSLVPSLTEAIAVSRPELLLAATDWCTHPPGLAVERVRGTKNPNLRRIAELAPDLVVCNQEENRRLDVERMREAGIPVWVTRIRTVDEAFTSMTRLFDIALGGAVPSWLSRAREVWSVPAPNPPIDAVIPIWRKPWMVVGRDTFTADLAGRLGLNLVHATGSERYPTVTESELVQGVRLAVLPDEPYVFTATDGPEAFAGIPVALVSGRDLTWYGPSLVEARGRLTAQLARVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Q2</accession>
    <name>A0A231H8Q2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="5">HIBADH</shortName>
            <ecNumber evidence="5">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mmsB_1</name>
        <name evidence="8" type="ORF">B7C42_02326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776808.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45201">
        <property type="protein sequence ID" value="OXR45201"/>
        <property type="gene ID" value="B7C42_02326"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="7">
        <location>
            <begin position="164"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="304" mass="31148" checksum="881947159A814D0E" modified="2017-10-25" version="1">MSVTKVAFLGLGHMGGPMAANLVRAGYQVLAYDPVPAAQEQARADGAEVFDTAAAAVTEAEIVITMLPNGRIVLDVYDAVLPSAKPGTLFIDCSTIDVADAKRAAEVAVAAGHRALDAPVSGGVGGATAGTLTFMVGGEAEDFAAAQPVLDVMGGKVVHCGGAGVGQAAKICNNMMLGISMIGLSEAIVLGEKLGLTHDKFYDVVSTASGQCWSLTTYCPVPGPVPTSPANNEYRPGFATALMNKDLGLAANALRDNGVEGRFGLLAAEIYEQFNRSAGDLDFSAIVTDIRRRSGAEPGQDSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8R8</accession>
    <name>A0A231H8R8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein Stp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">stp_5</name>
        <name evidence="7" type="ORF">B7C42_02373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776758.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45248">
        <property type="protein sequence ID" value="OXR45248"/>
        <property type="gene ID" value="B7C42_02373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="487" mass="50179" checksum="40288C6F7CE228E2" modified="2017-10-25" version="1">MSTLETPTAPTLLRTPPADVVPYPARWRVLPVVLSAMFMAMFDWFVVNVAASSLQHDLNAGEAALELIVGGYGFAYASGLITGGRLGDLFGHRRLFVIGMLAFTVASLLCGLATDAWTLVGARVLQGGTAALMVPQMLALINTLFPPLERPRAMAAFGATIGLGAVAGQVLGGILLDADLFGWGWRTIFYINVPIGVVAAALAARWLPRAGSTRRARLDPVGAVGISAALALLLIPITLGRPEGWPLWTWVSMAAAAPALLATLRYENRLAHRGGEPVLDTAMVRERGFSLGLVIAGGYLTFFAGFMLCLTLMLQGGLGLSPLRAGLAFAPLGLCFAGSSLFLAPRVADRFGNRVMVIGTCTSLTGLGITLAVLAGMGTQVSALALIPGMMIVGLGNGMTIPSVVSAVLSSGIPAPQAGMAAGVLTTAQQFGNAIGATVLGVIFFSALGAVHTTGSYVTAMEMAAVAGIVVLAVVLAAALALPRQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8S4</accession>
    <name>A0A231H8S4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776584.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45423">
        <property type="protein sequence ID" value="OXR45423"/>
        <property type="gene ID" value="B7C42_02548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011235768" evidence="1">
        <location>
            <begin position="31"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="481" mass="51069" checksum="29D7BCA6FD648BA2" modified="2017-10-25" version="1">MAKRPVTATLAVLVLAVGLLAGCTMTTGGHAVSIYDDPFQVAGLPTTSGPSGPRSGVPDSALTATGGDKGGVDTLALNAIDDIQSYWRGEYHNEFQGDFTPVTKFYSWSAKAPRSQETQFCKDTTYHLVNAAYCRLDNSVGWDRGVLLPMMQDSFGKMAVVMVLAHEYGHAIQTMSRIVTAKDPVIVKEQQADCFAGAFMRHVAEDKAAHFTINTSDGLNNVLAATVAIRDANPEDPESVHGSAFERVTAVQIGFTDGPKGCKAIDMKDIDRRRKNLPQSFGDDVNRGELAITKDSLKELSKAMAAIMPIPSEPAYDYHGALMHCSNGADTVPVTYCPATNTIGTDIPALAQRGAANTDEQDGFPTRVGGDYNAYVVFVSRYALAVQRNAHQQLTGAKTGLRAACLSGVITARLADPHRDAGQGDIALSPGDLDKAVSGLLSDGLAASDVEGKTVPSGFSRVDAFRAGVLGTQEICEARYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Y4</accession>
    <name>A0A231H8Y4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner membrane protein YhjD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhjD</name>
        <name evidence="4" type="ORF">B7C42_02450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776664.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45325">
        <property type="protein sequence ID" value="OXR45325"/>
        <property type="gene ID" value="B7C42_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005274">
        <property type="entry name" value="IM_pro_YhjD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00766">
        <property type="entry name" value="TIGR00766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="36278" checksum="D1E791CAC44F0B30" modified="2017-10-25" version="1">MLDKVKARIQREVRARPWLDHAVRAGGSYQRQRGDYFAAGITYFTVLSLFPLLMVAFAVAGFVLARDPHLLEELRDKIVENIPGSFGGQVNDLIDQAIKSRTSVGLIGLFIAAYSGLGWMANLRAALTEQWEQPAHEGNWFKTKLSDLMALAGLGVAMVVSLGLSALSSSGLALQLLESVGLDKAPGVSWLLRLLTLVLAVLASWAVFVWIIARLPRQPVTFTSAVRAAFIAAIAFEIWKQVASFYLQKVLTSPAGVAFGSIIGLMVFAYITARIILFATAWAATARENEVEAEIPAPGPAVIEPRMHAGMTASTGLALFGVGAALGSMIGIARRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H905</accession>
    <name>A0A231H905_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">B7C42_02436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45311">
        <property type="protein sequence ID" value="OXR45311"/>
        <property type="gene ID" value="B7C42_02436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15750" checksum="2F1E1FFD14E497F5" modified="2017-10-25" version="1">MIEPIPLRLHLIDTSAYARLSDPGVRTVIAGLLADRAAATCVTLDLEAGYSGRNLADVQNIAHSRRARFTTLPVTEPIADRAREVQLLLARQGKHRAAGIVDLLTAAVAEYHGATILHYDEDFEHIASVTRQPHVWVVPRGSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H970</accession>
    <name>A0A231H970_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase SadH</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sadH_3</name>
        <name evidence="2" type="ORF">B7C42_02401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45276">
        <property type="protein sequence ID" value="OXR45276"/>
        <property type="gene ID" value="B7C42_02401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="29382" checksum="5D72A033C439B340" modified="2017-10-25" version="1">MNLFGNGYPPIDLVAARVLITGAGRGIGRATAESFAHKGSEVVLADVDAAAATAAADALGARAVELDVRDRQRWDEVVAELGPIDILVNNAGVMPAGPFLSEPDAVGHTTIDVNVWGLIHGMRAVAPAMIDRGRGHIVNVASLAGKIPLPGLAVYNASKFAAVGLSAATRLEFAESGVSVSCVLPAAVRTRLSSGLTLGRGLPTVDPVDVAAAIVKTCRSRRAEVAVPQYLDPVDIALAAAPESVVRRVRGLFDGDRALHPGDAAVRAVYEDQVRAIGREPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9P4</accession>
    <name>A0A231H9P4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45417">
        <property type="protein sequence ID" value="OXR45417"/>
        <property type="gene ID" value="B7C42_02542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="13490" checksum="3AE7B37EA50E702A" modified="2017-10-25" version="1">MDPLKLDKSPTLDDSANSAPPPTATASAPDAVMRVDPAAMAAYTAIANTVSQQLASAASVTAGAVDPQQLATDLGLVGADFAAKFAAAVSEHAQALSTAGKLVSAYGRGLHTYTAGVQGTDEDSAVAITRTESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC2</accession>
    <name>A0A231HAC2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Caffeyl-CoA reductase-Etf complex subunit CarC</fullName>
            <ecNumber evidence="9">1.3.1.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">carC_3</name>
        <name evidence="9" type="ORF">B7C42_02090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.108" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782523.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45798">
        <property type="protein sequence ID" value="OXR45798"/>
        <property type="gene ID" value="B7C42_02090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="227"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="43414" checksum="ABB9CC52CCF68CFE" modified="2017-10-25" version="1">MDALAEFRERVRQWCAANIPPEWRTRQTGATDAEFVEFQQEWFQRLRAGGFAVPHWPREWGGGMPVAQQAVLYSELAAHDAPRLVLAFVSIHHAASTLLAAGTAAQRERHLPAILDGEIWCQGFSEPDAGSDMAALRTSARRHGDTYLVNGRKLWASGAAFADWCLLLARTDPKAPQRQGISYFLLDMRSPGVEVRPIRQATGEWHFCEIFLDDVEIPAANLIGPENQGWQVAQRTLGAERGLTMLELAERLAHGGFRRLVSLCARPRPGGGCALDDPPVADRLARLETELAGLRGLCADLVAAERPGPADASIVKLYYSELLQRMTDFGTEVAGVSAHAVLRKPRSSGWESGAWMLDFLGSWEWTIPGGTSEIQRTIIAERGLALPREPVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAK7</accession>
    <name>A0A231HAK7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45767">
        <property type="protein sequence ID" value="OXR45767"/>
        <property type="gene ID" value="B7C42_02059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="164" mass="17955" checksum="C8E267634D33346E" modified="2017-10-25" version="1">MTAEPTVDLTDVTYRRLTPADGDAVRDLHATLTRRDGYYRFFGARPKHLEHLAAAMSMNDPKHCAFGAFTGDRLIGVANYVVLPDTDCAEVAMVVAHEDQQSGVGTALLTRLAAEARRHGIGRLAGDIMATNSKMMQLLMDIDLPMSAHRDDDVVHVVLRLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAL8</accession>
    <name>A0A231HAL8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-[(3aS,4S,7aS)-7a-methyl-1, 5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD3_3</name>
        <name evidence="3" type="ORF">B7C42_02154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45862">
        <property type="protein sequence ID" value="OXR45862"/>
        <property type="gene ID" value="B7C42_02154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="395"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="475" mass="51179" checksum="3F86DDFE1D265CF6" modified="2017-10-25" version="1">MSWETIPQMVASSADRFGDAEAIVDGDLRLSYTELVDRVRRAAGAFAEAGVGKGDRVAIWAPNSAAWIVAAFGLLTAGGVLVPVNTRFQAAEAADVIGRSGAKLLLVQQGFLGRELRGPDGVPVIDLASDFLSSGSPFEREVAGTDISDIIYTSGTTGRPKGVMMNHRQNLRLYTEWCELADLREGDRYLAVNPFFHTFGYKAGVLASFIRGATILPVPVFDVDRVCELVARERITMLPGPPTLYHSLLEARGRYDLSSLRSAVTGAADIPVELIRRVKTELPFRSIMTGYGLTEAGTATASRPGDTFEQIATTAGTPCDGVEVRIAADNEVLLRGYTIMQGYLDDPAATAEAIDAEGWLHTGDLGALDESGRLRIIGRKKDMFIVGGFNAYPAEIEGLLLQHPAVVQAAVIGIPDERLGQVGKAFVVTRAPLTEAELIAWSRENMAGYKVPRAVVFLDELPLNATGKVMKDQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBY1</accession>
    <name>A0A231HBY1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46391">
        <property type="protein sequence ID" value="OXR46391"/>
        <property type="gene ID" value="B7C42_01357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="734" mass="77816" checksum="B69690EB935E2B56" modified="2017-10-25" version="1">MFSAPGFARGWAPVPAWSARRRGDVRRDRGRGDRSGHENAPTGAVAEIASSGTPIDSTTEVAPRGPSAADSLGSTRAVPRGFSGLRSTADFAGLRAVPHRPVLLVAVLLILAQIALRGWVAGRGYFYWDDLILVGRADRYPLWSADLLLYDHDGHFMPLAFVTAWVVTRIAPLQWAGPVVTMLLLQLAASVAVLRMLLVLVPRRAGAVRWAVLVPLIGYLFCPLTLPAFAWWAASLNALPLQFALAWVIADAVLLVRTGRGRYAVSGVLVLIVGLLFFEKAVVVPFVAFAVAVLERYVVGARTVDADSPAGEAESGPRDAAAPPEDPERAGDRGGPSVWASTRDVARTGAALWAGSALILAGWGAAYLTVADHIAVDTSLAGARRLLHSATSLGILPTLLGGPWVWARWLPSTPWATPPGWTVVPAWAILAAVVLVTLRLRRRVLPVWILVVGYVLAVQLPIVLIRGGPNTAAELMQSLRYLADVAVVLAAATALLLAARPRTRSRNADALGPTSPGPVPAAHAVAIVLTAAFVVSSVCTTVSFARSWEISPTRTYLTNARAAFADRDGAPLLEQEVPWGVLTPMTYPQNLIAQVLGPIAPDGAFGTSTPHLRMITDDGELVDASVWWNRRILAGPEPGCGYRVDGSDPVALWLDGPMIEHGWTAQLNYFANQDGHLTVAMEHGDAVVVPVRAGVHTVFVHVVGSGEVLRIGSRTSGLDVCVGVGPVGVAAFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBZ2</accession>
    <name>A0A231HBZ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rplI</name>
        <name evidence="9" type="ORF">B7C42_01305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514150.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46339">
        <property type="protein sequence ID" value="OXR46339"/>
        <property type="gene ID" value="B7C42_01305"/>
    </dbReference>
    <dbReference type="GeneID" id="66717847"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="151" mass="15881" checksum="C2BDFF199BBB02C5" modified="2017-10-25" version="1">MKLILTADVDNLGAPGDTVEVKDGYGRNYLLPRGLAIVATRGAEKQVEGIRRAQDARRVRDLDHAKELKAAIEGLEGVSLSVKTAGTGKLFGSVTTADVAGAVKAAGGPVLDKRSIELPKSHIKSTGKHNVTVHLHPDVIAKFDLQVAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC53</accession>
    <name>A0A231HC53_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4328 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46524">
        <property type="protein sequence ID" value="OXR46524"/>
        <property type="gene ID" value="B7C42_01494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025565">
        <property type="entry name" value="DUF4328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14219">
        <property type="entry name" value="DUF4328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4328" evidence="3">
        <location>
            <begin position="140"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="40255" checksum="687FB71B6BF7965D" modified="2017-10-25" version="1">MSTVVQPCARCGARWAVHGTPMHWCPRCRGVLLSPAPVDAPPERRNYRWVARPPGRGPRVERPRPAPAIDPATPRYTEIPRWGLRDRPPHVAAAPQNRIQAVLHWLTERVAGLLLATVILFGLSAVAEFGRYLILLRNRTRLIQPLLLFFSDLTVYATSVAALICALITAVGLLGWLVRARRSAYAGNGRRDPRSLRALLCGGLIPVVNLVWPGVFLTELARQLGGDPRTLRAVRIWWCVWVLNGVMVIASLFWRTADTLQGQADGVIFTVYTDLVAVAAAVLSLWVLRMCEGRDLRGRIRMAKRWLPAAGPAVPVIEPVHPVTAVDTPDRAAAGNAETPHTEAEHTGAENTEAERVEQEEVMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC82</accession>
    <name>A0A231HC82_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore coat protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cotA</name>
        <name evidence="4" type="ORF">B7C42_01427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46458">
        <property type="protein sequence ID" value="OXR46458"/>
        <property type="gene ID" value="B7C42_01427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012149940" evidence="1">
        <location>
            <begin position="32"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="141"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="429"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="597" mass="65699" checksum="90EF3E8813B30158" modified="2017-10-25" version="1">MYRPIGRRAVLRGLGAGLTAAMAGRAATATADPAPGGFESPLIFHSPPMRPFVDELPRPPVVTGSHLDLVAYTTSHRFHRDMPAVPAFGYNDQTYLGPTVEHEAGRPLTVRFHNRLGDHPFAGDIDTTLHGVPESYRTTVPASLHLHGGVTPPASDGHPERLVVPGQHLDHDFPLRQSAGHLWYHDHVMGITRANVYAGLTGMMLLRDEFDTGAPDNPLGLPAGEFEIPLVLQEKLFNPDGRQSLRSTAVVPPGSWEGGAVGDVGVVNGVVWPQLPVARGLYRFRAINAASFSTWNLFFGNRMRFWVIGNDHGLLDAPVPVRNLRLAPAERIDLLVDFADLAPGETVDLCNDEQPVFQAAILGEVAMPVFCRFRAEDRTGWRGPVPQTLRGGPRQPAVLPPVRVPALSRTLTISQPYELRVPPAIMSLNNLRYSDPDIDMPRQGTTEVWNIVNITPDPHPIHIHLVDFRILSRTPLRTVDYQLAHPQPPIGIRWTPDPEGFLAGPAQPPAPWESGRKDVVRVDGGTVTRIVVRFPTADELGFDPDASFPRIGPPMPGAAHSAEHAAHQDSDLRGFVWHCHLLDHEDHDMMLRFRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC85</accession>
    <name>A0A231HC85_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCA-adding enzyme</fullName>
            <ecNumber evidence="5">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cca</name>
        <name evidence="5" type="ORF">B7C42_01398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781814.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46432">
        <property type="protein sequence ID" value="OXR46432"/>
        <property type="gene ID" value="B7C42_01398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="271"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="53975" checksum="53C0408E4E16B6DD" modified="2017-10-25" version="1">MSDPDDDRRTRLLAAAAITLGRLSDVLTPLGGLFAARGHELYLVGGSVRDAVLGRLGTDLDFTTDARPEVVLEIVRGWADNLWDTGGLAFGTVSASKSGWQLEITTFRSDSYDRVSRNPEVTFGDSLEGDLVRRDFTVNAMAVRIGPAGDLEFVDPLDGMEALLAGVLDTPAAPEDSFNDDPLRMLRAARFVSQLGFEVAPRVRVAIALMADEIRRITAERVRTELDKLIAGEHPTDGIDIMCETGLAERVLPEVPAMKLEIDEHHQHKDVYQHSLTVLRQAIDQEQGDPDLVLRWAALLHDIGKPPTKRNEPGGGVSFHHHEVVGAKMVRKRMRALKYPKQFTEDVARLVYLHLRFHGYGKGQWTDSAVRRYVTDADDLLPRLHKLVRADCTTRNKRRAALLRSTYDDLEARIERLQQEEDLQRVRPDLDGNAIMELLGLEPGPQVGRAWRYLKELRLDRGPLTRDEAEAALLEWWNAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC92</accession>
    <name>A0A231HC92_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46465">
        <property type="protein sequence ID" value="OXR46465"/>
        <property type="gene ID" value="B7C42_01434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="7544" checksum="FE39BB81C79A9B46" modified="2017-10-25" version="1">MSIRYQFVIDGELSERALAAFPELSRSEHSSAGTTTLFGALSDATAMRGVLARIDSLGLTLLGMAQLPDSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCL7</accession>
    <name>A0A231HCL7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46417">
        <property type="protein sequence ID" value="OXR46417"/>
        <property type="gene ID" value="B7C42_01383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="416" mass="45554" checksum="FEF0591153313891" modified="2017-10-25" version="1">MDSARSRQAAEVEAAQVAGAADIDDAPQMVIDPRFVPVVHHFFRLFPRPNRGGGAFAVFLHGRPVVDVWAGWSAPDQRWQSDTVALSFSTGKGVVTTVLHRIAERGLVDYDAPVAEYWPEFAANGKQDITVREVLSHRAGLHKVRGLATDADGILDYNAMIAALAAAEPDPRRLQGSGYHAVTFGWLVAEIVQRATGEPFTEVLRREIAEPLQTEEFWYRVPESERYRIARTFPRLRIPGLRWDTASKVIARSRTVGAIAEAGMPAGFDVLVGDARVHDAVMPGFNGVFSARALARMYGALANEGRVLLPDRTWSEPLLRPETIENINHVQRSEHRDYVIGVPVPFTLGYHRPPIASRRPLRRAFGHYGVGGSGAFADPESGMSVAFVTNRLGNSLNTIGDGRLARLAAEARAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCR5</accession>
    <name>A0A231HCR5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46704">
        <property type="protein sequence ID" value="OXR46704"/>
        <property type="gene ID" value="B7C42_01679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="22011" checksum="8FD588FEE938B7E3" modified="2017-10-25" version="1">MDVLSFVSSLVWPGVAVTGLVMFRKNLNRWMEERPQELKVAGVLEAKWREQADRVVEETAAAREGELPEGSDADWPGGRMPLALKLLDKVREVPVLAILEGWGEVEEELEKALVAWDPTTVRNRDGKPNLAQLIRRATTANELPGWVEHNYNAMRKLRNLAAHSMAVDPSQAFEFLSLADLVMNELRRRATAQSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD56</accession>
    <name>A0A231HD56_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46705">
        <property type="protein sequence ID" value="OXR46705"/>
        <property type="gene ID" value="B7C42_01681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="35381" checksum="0F5ACF6E1C5561D1" modified="2017-10-25" version="1">MSVEQERREALLSQLPGKEHYDRFDGLNRASQVFSGNGQELSGLLRHFIGTDLHVERLPDGYDVEVMRRFHNYVASVATLRDVQRATHRKLWPDRVSPDDSQNQKTVWEVEIYSPKAEEVFGSDSIKFLFDLRNFTVHYSIPPLTLGTTIRWEGGGPVVQENKVELKRAELLKYRKWGSAAKRYLKSHEGDIDFLSILEEYSTAAREFYEWFWCQVESKVRGDVDEFLAKSNELGLWLTEHNARPDWSVEGEPVRGSLRRNRARTRAARAEHGTRGWNRYLMIDEHGVASVAPSGDTWDPFPATKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD89</accession>
    <name>A0A231HD89_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_00038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46923">
        <property type="protein sequence ID" value="OXR46923"/>
        <property type="gene ID" value="B7C42_00038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="275"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="40032" checksum="523EEC04998FB59E" modified="2017-10-25" version="1">MSEPRTSVIVSGARTPVGRLLGGLSGFSGSDLGGFAIKAALERGGVAPEQVDYVIMGQVLTAGAGQIPARQAAVAGGISMDVPAVTVNKVCLSGINAIALADQLIRAGEYEIVVAGGQESMSRAPHMLEKSREGFKYGDVTLRDHMAYDGLHDIFTDQAMGALTESRNAGDGIGRAEQDAFAAASHQKAAAAWKNGVFTDEVVPVSVPQRKGDPIVVSEDEGVRADTTVESLGKLRPAFAKDGTITAGSASQISDGAAAVVVMSKAKAQELGLSWIAEIGAAGVVAGPDSTLQDQPANAIAKACAKEGISPADLDLVEINEAFAAVGIASTRKLGIDPEKVNVNGGAIAIGHPLGMSGARIVLHLALELQRRGGGVGAAALCGGGGQGDALIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD91</accession>
    <name>A0A231HD91_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46839">
        <property type="protein sequence ID" value="OXR46839"/>
        <property type="gene ID" value="B7C42_01817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="33105" checksum="F455BB1C68B69FD9" modified="2017-10-25" version="1">MTNIGEDSSTTLPRRQLGRYLKEARLGVGLRLEDVAPLMQWSASKLSRFEAGKSPSIRVLDVEALCGIYDIDDPEVIAGLVGLAKQSTGKSWWQAFDDVISGNFDLYVGLESSARQLSIFRPDMLPGLLQTPNYARLLEQIYFPKIARDELERRTELKRRRQVLVTRKTNPARVDLVIQEAVLRTMVGTPAIMAEQLRHLADAPANVAVRVLPFAAGFPLGTPPGPFTILDFGQDSKGRDISPTVVYIESYAGDMYLERNADVGRYRQAYNVIQQAALDVAESKRLLRHTAREFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDH2</accession>
    <name>A0A231HDH2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxygen-dependent choline dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betA</name>
        <name evidence="5" type="ORF">B7C42_00087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46971">
        <property type="protein sequence ID" value="OXR46971"/>
        <property type="gene ID" value="B7C42_00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008812">
        <property type="term" value="F:choline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="532" mass="57718" checksum="9F29FE682D59918B" modified="2017-10-25" version="1">MNNEVFDFVVVGGGSSGAIVASRLAEGGAQVLLLEAGGSDRRIDVRIPAAVAVAYQRVNWKYPAEPDPSRTGRPEAWMAGKVMGGGGSINSCVFVRGNRADYDGWAKEGCTGWDYESVLPSFKRLESWEGGESDLRGGSGPISVNVQSNQGEANSAYLQACLEAGYTRNYDYNGATQDGVGFAQVNHRRGTRSQASREYLRRVAPKGKLTVRTGSYVHRVLIEGNAAVGVRYRHKGVESQARVRQEVVISAGSIGSPRLLQLSGIGPRAALDGVGVEVVHHLPGVGENLHEHPYLMQRWRSTIPTINKMRAGTIVKALTDYAKNGSGLLAMSMVQVQCMGRTERGLDSPDLQLQFVPFAITRAVDKNGMFNVQPAKEEGFLSASTFLRPRARGTITLRDSAPDSTPRISYQFLADQDDVRDCLRGLREVQRVMSQPAMAAITSGQLQPEADCRTDADWERYVRQTVTPSYHPVGTCKMGVDDLAVVDPELRVHGIRNLRVADASIMPRITTGNTNAPSMMIGERAAELILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDM2</accession>
    <name>A0A231HDM2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Excalibur domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498971.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46896">
        <property type="protein sequence ID" value="OXR46896"/>
        <property type="gene ID" value="B7C42_00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008613">
        <property type="entry name" value="Excalibur_Ca-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05901">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00894">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011285435" description="Excalibur domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Excalibur" evidence="3">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="10060" checksum="9DF988E11ED275CE" modified="2017-10-25" version="1">MNVRRLIVTGAGLITLAAPIVSTAPSALADGFIPTGSAGTGSSGIDDAIGATGSAGLTQTGSAGGTFKNCDEARAAGRAPLFRGEPGYSPHLDPDGTGMACPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDS3</accession>
    <name>A0A231HDS3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46895">
        <property type="protein sequence ID" value="OXR46895"/>
        <property type="gene ID" value="B7C42_00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="8136" checksum="C79B0A2A949BB7EB" modified="2017-10-25" version="1">MARDTEHIEREIEAARNRLAGTLDELAVRADPQRIAGNTKKAVVAKLNEPKVKYSLIGAGALVGVLVLIKIFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDU4</accession>
    <name>A0A231HDU4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mutator protein MutT4</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mutT4_1</name>
        <name evidence="3" type="ORF">B7C42_00223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47101">
        <property type="protein sequence ID" value="OXR47101"/>
        <property type="gene ID" value="B7C42_00223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="189"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="36548" checksum="BF7027E44D22799F" modified="2017-10-25" version="1">MASKPVSELHRAIEIFGRRGRKLSAARLEEIDAILVALLPDYRELDIEGKQRFALLVVAEIRSAIEQFNDSVDRRIADAVLAVSSEFHDKTVTARRQFVLENDCGFSEDQFKNRRRRIIRDIAQYLEAAMRDRDSHAHASIAESLDSEEPSQSADQKIEPIDNSSVTISVSGDYLGNINIHQTSLDAISLPVAVGIVVDGPPARADKVLLVRRRERYGALDWQFPAGIVKPGEIPAELIVHEVAAETGVHCSVVDLLGQRVHPITNVRIIYFLCRYISGIADNLDPNENRDVIWCEVASIGRYIPIENIYLPAYQRLQLMAARDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE48</accession>
    <name>A0A231HE48_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prmA</name>
        <name evidence="2" type="ORF">B7C42_00342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47220">
        <property type="protein sequence ID" value="OXR47220"/>
        <property type="gene ID" value="B7C42_00342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="24098" checksum="4F4B8987AA778C69" modified="2017-10-25" version="1">MHAGVMTQAAEFWNTVYDDDTAPWVIGEPQPAIVEVERQGLIRGRVLDVGTGAGEHTIALTALGYDVLGIDLSPSAVEYARRNADAKGVPAARFRVADAVRLGADPAAAAELGVFDTIVDSALFHIFREDPGNRADYVRSLHTLCAPGGLVHVLALSDADPGFGPRISDRLLRESFDAGWELEDLRPASYRGRVTPVVADQVAGLDVAEDGTVDTAAWLARIRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE76</accession>
    <name>A0A231HE76_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin reductase</fullName>
            <ecNumber evidence="3">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcD_2</name>
        <name evidence="3" type="ORF">B7C42_00198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777009.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47078">
        <property type="protein sequence ID" value="OXR47078"/>
        <property type="gene ID" value="B7C42_00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="323"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="42993" checksum="73FA7294437D86BF" modified="2017-10-25" version="1">MPTDSRFVIVGGGLAAAKLAESLRDNEFDGAITVIAEEAQLPYERPPLSKEHLLGKKSLADFTVHTEQWYRDHDVDLLLGTTVTSVDRSSKTVALPDGSTRPYDKLALATGSRSRRLPIPGADAEGVYMLRTIGQSDALISLFGSARRLVVIGAGWIGLEVTAAARTAGLEVTVLEVGAVPLQAALGDEMGAVFGELHRAHGVDLRCGVKAAEIVTADGKATGVRLSDDTVVDADAVLIAVGARPNIELAADAGLAVEGGVLVDESLASSDPDIVAVGDIADQQHPVLGQRVRVEHWATALNQPAVAALTMLDRPATYDRLPYFFTDQYDLGMEYTGFVAPGATTSVVVRGDTASREFVAFWLDQGNRVLAGMNVNVWDVTDRIKELILGGEPVNPDALADTSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE85</accession>
    <name>A0A231HE85_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47204">
        <property type="protein sequence ID" value="OXR47204"/>
        <property type="gene ID" value="B7C42_00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="59" mass="6641" checksum="6A421C56D275A234" modified="2017-10-25" version="1">MGDHPQRTPLYGVVLLLGVLILGIWVHELPYVGLQVLAYILLVMIAAPAFVMTFRDYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEB2</accession>
    <name>A0A231HEB2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777824.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47281">
        <property type="protein sequence ID" value="OXR47281"/>
        <property type="gene ID" value="B7C42_00403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7207" checksum="ECF7580DFBD08D2B" modified="2017-10-25" version="1">MSQARHITLVHEQSEFAETRAAEKAEAARRSALAARAVASHSTGVDDCQALLTMLGLDAAAGKLVAESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEB7</accession>
    <name>A0A231HEB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47116">
        <property type="protein sequence ID" value="OXR47116"/>
        <property type="gene ID" value="B7C42_00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="43076" checksum="E850BFC96710B18E" modified="2017-10-25" version="1">MQDHLERINKLQTIIVAIVVAGGGVALMVFGKQLPSLPNLVWLNFFPWTEVGGTLLVAGVLGLGIDYFTGKDRDERDTARLKRVLADSAPAMRDAVIDGFAFGNQDLARVASPETLDDIIRNSLALRLGDETFADEVYQDVRDQAVRAPERWHDATVEIRLTPLPGISRTSTQDAHAEPAGSNLFGVSVRWEYSVVPKHHSRHFAVVANRREYLDLTNGHDGTSAWVLVPKPGVDPTKPAAFELVQFSVDGNDRPIRRAGRKGGQVYSVDLGLDARQAEQPVTVAYTYRTVTEQRGNLLYIDIEQPTRGITVELDYSDCDIERIRVLDFIASSRTARIERSPDPVPGKTVRVGFDGWAFPRSGVGFVWTLNQDPSGSTGRNSELTKTLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEJ9</accession>
    <name>A0A231HEJ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zur</name>
        <name evidence="3" type="ORF">B7C42_00421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47299">
        <property type="protein sequence ID" value="OXR47299"/>
        <property type="gene ID" value="B7C42_00421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15747" checksum="BE3DD46A8AC6E748" modified="2017-10-25" version="1">MTVPEKTGTAEKTVGIRSTRQRSAITALLGDIEEFRSAQELHDELRRRGEGIGLTTVYRTLQSLADAGKVDVLRTDTGESVYRQCSKGHHHHLVCRQCGRTVEVEGPTVEAWAAAIAGEHGFTDISHTMEVFGTCRDCAHLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HET3</accession>
    <name>A0A231HET3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma70_r4_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47372">
        <property type="protein sequence ID" value="OXR47372"/>
        <property type="gene ID" value="B7C42_00495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="18503" checksum="99FE7646927EFA2E" modified="2017-10-25" version="1">MSGQPEPAPPSRDEHAGWEEILHGNVDWVYALMLAKVGAAPDAEELTTEVFMTALEPSPIGAAPIGVEPSQIPALLRETARSVLARYWLSRVGREITVIDAEPHGTSSATPVAAVADLLAELPEPYRRILELRFLQGLSIQDAAARLGVGVPEAEARQRLALRSAARPGSGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEX7</accession>
    <name>A0A231HEX7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron-dependent extradiol dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hsaC_1</name>
        <name evidence="9" type="ORF">B7C42_00349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.25" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47227">
        <property type="protein sequence ID" value="OXR47227"/>
        <property type="gene ID" value="B7C42_00349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047071">
        <property type="term" value="F:3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 7 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="143"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="31859" checksum="7B409A83F08E7CE5" modified="2017-10-25" version="1">MAAVSSLGYVRAQIADVAAWREFAFDTIGFAEGSGPNPASIYLRTDEHTYRLELVPGERDEVIAVGWQVADRRSLTLVRETLAAAGIEVTELTLAEAAARHVEEAISFTDPAGFTVEVFHGPLLDHSPVVGKYGNRFVSGDLGLGHVVLPVPDIEAARQFYTEVLDFASRGSFRVGPPDHPIWIRFMGVNPRHHSLALIPGGRGDGPGIVHVMVEVDALDDVGRALDRVTKAGYHLSSSLGRHTNDKMISFYVRTPGGWDLEFGCEGMLVGEDYVAEEMTADSYWGHEWARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFD2</accession>
    <name>A0A231HFD2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47436">
        <property type="protein sequence ID" value="OXR47436"/>
        <property type="gene ID" value="B7C42_00559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="19750" checksum="3D99D87A2ACD5404" modified="2017-10-25" version="1">MHFPTHTLDSAPAEARRTMTASAAHIGYLPAAVAKMATSPRLLDGFMKLNALFEGGTLDELSREVLVMTVATRNECHLCVAMHTAKLTAIGADPAVIAALRDQRPLPDPRLAALQEFTLTVVETAGNVPDERASDFLAHGYTPEQALEVVLGIGTYTLSTLGNRLTAAPLDPALTAFAWSAGQRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFF0</accession>
    <name>A0A231HFF0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">ppk</name>
        <name evidence="13" type="ORF">B7C42_00581</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47456">
        <property type="protein sequence ID" value="OXR47456"/>
        <property type="gene ID" value="B7C42_00581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="10">
        <location>
            <begin position="39"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="9">
        <location>
            <begin position="155"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="12">
        <location>
            <begin position="377"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="11">
        <location>
            <begin position="550"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR47456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="736" mass="81867" checksum="A705B446B0F69987" modified="2017-10-25" version="1">MSVSETETVPQQPRLPAAPPAATPPPTTAAAAQLPADRYLNRELSWLDFNARVLALAEDPSEPLLERAKFLAIFSSNLDEFYMVRVAGLKRRAEAGLSVRSADGLSPTEQLTLIAERTQELAGRHARVFLDQVRPALAEDGIAIIGWADLDDDERGRLSGYFLDQVFPVLTPLAVDPAHPFPYISGLSLNLAVTVKDSETGGEHFARVKVPDNVDRFVRVRRTLNETPGARRDSDITAAPRLAAFLPMEDLIAAHLDQLFPGMEVVEHHSFRITRNADFEVDEDRDEDLLQALERELARRRFGSPVRLEVSDDMTEHMLELLLRELDVDPGDVIQVPGLLDLSCLWQVYGVDRPLLKDAPYVPATPPAFGERETPRNVFAALREGDVLVHHPYDSFSTSVQRFIEQAAADPQVLAIKQTLYRTSGDSPIVNALIDAAEAGKQVVALVEIKARFDEQANIKWARALEQAGVHVVYGLIGLKTHCKTCLVVRREGATIRRYCHIGTGNYNPKTARLYEDVGLLTAAPEIGADLTDLFNSLTGYSRKANYRNLLVAPSSVRSGIVERIRRETELAAQGVPARIRLKANAIVDEQIIDALYRASQAGVPVQIVVRGICGLRPGVPGMSDNIEVRSILGRFLEHSRIMHFQAQDEYWIGSADMMHRNLDRRVEVMAQVKDPKLRERLAVVFDSALDPATRCWVLQPDGSWAAQPSPEALGRGVQVRDHQEFLMRLRRPDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFG5</accession>
    <name>A0A231HFG5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene synthase</fullName>
            <ecNumber evidence="1">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crtB_2</name>
        <name evidence="1" type="ORF">B7C42_00704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779615.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47579">
        <property type="protein sequence ID" value="OXR47579"/>
        <property type="gene ID" value="B7C42_00704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017827">
        <property type="entry name" value="HSQ_synthase_HpnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480:SF17">
        <property type="entry name" value="PTHR31480:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03464">
        <property type="entry name" value="HpnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="284" mass="30408" checksum="6D2D176428CA94EF" modified="2017-10-25" version="1">MDAATAPARWLRAREKEENFPVALRWLPREPRRHLHAVYAATRLIDQVGDAAPGDRVSHLLALRADLAGLYQGRTPDDPVLQMLAPTVAACDLPQEAFQELIEANLLDQRVGRYASFEDLLGYCRLSANPVGRLVLAVFDQSTPDTVALSDRVCSALQVLEHCQDVAEDYAAGRIYLPQDDLAAAGVADAALATGGPGDPACRAVVLTQVERCESMLGEGAPLVARLTGWARLAVAGYLAGGCATARALRVAEGDVWSQPVRPRHVDTVASMVTLLGKATVVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFK0</accession>
    <name>A0A231HFK0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47751">
        <property type="protein sequence ID" value="OXR47751"/>
        <property type="gene ID" value="B7C42_00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10063" checksum="98136282D3E46F64" modified="2017-10-25" version="1">MTDPAAIAAAVVLGTAVVVAVAASWAALRPRGVYARLHYPGMLTSVTGPLLTLAVLLDYGPGLTTAIVALTAALLWVTAPVSSAAIGKLNVVLGERKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFY8</accession>
    <name>A0A231HFY8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779680.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47802">
        <property type="protein sequence ID" value="OXR47802"/>
        <property type="gene ID" value="B7C42_00927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="128" mass="13735" checksum="B1AC2947417D8F55" modified="2017-10-25" version="1">MVNKTSAASIEFDRLGMLVWAYLVTAVATVAALAILSVTAPHEAPREAWGHAVIVAAFAVLLPLRFRSARRGSVAALRAVGLIAAALLLVNVIEALLPHFLPGWMRVEMFGIAALMALIILLVVRERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG04</accession>
    <name>A0A231HG04_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobO</name>
        <name evidence="1" type="ORF">B7C42_00740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503569.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47615">
        <property type="protein sequence ID" value="OXR47615"/>
        <property type="gene ID" value="B7C42_00740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="22810" checksum="6973DFABF6ED159D" modified="2017-10-25" version="1">MPKGVPETIPDDGLTTRQRRNQPVLAVHTGPGKGKSTAAFGMALRAWNQGFDIAVFQFVKSAKWKVGEEAAFRTLGRLHEETGTGGPVEWHKMGEGWSWTRKQGSEDDHAAAALAGWREIARRLTAEQHRFYVLDEFTYPLKWGWVDVDEVVETLRNRPGNQHVVITGRDAPQALVDAADLVTEMSKVKHPMDAGRKGQRGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG90</accession>
    <name>A0A231HG90_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicarbonate transport ATP-binding protein CmpD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmpD_1</name>
        <name evidence="5" type="ORF">B7C42_00973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779646.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47848">
        <property type="protein sequence ID" value="OXR47848"/>
        <property type="gene ID" value="B7C42_00973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="29044" checksum="E3527247C0D5D7CE" modified="2017-10-25" version="1">MSITAINGVSVEIHGLGISFGAADIVSDIDLTVAEGEFVCLLGPSGCGKSTLLSSMAGFVEPTAGDIYCDGTAVKGSNAHAGMVFQSSEALFEWMTVRQNVSYGPRMRGANKAEQTRIAAEYLAMVGLPHSGDKYPSQLSGGMRQRVQIARVLANQPSLVLMDEPFGALDAQTRQVLQVELDKIWRHTGCTVVFVTHDIDEALTLADRVVVMSAGPRARIKSIYQVDAPRPRDRAHPDVIDLYEQLRDDIRAEVVASLRNQGIEEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSB5</accession>
    <name>A0A231GSB5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000828">
        <property type="protein sequence ID" value="OXR39527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39527">
        <property type="protein sequence ID" value="OXR39527"/>
        <property type="gene ID" value="B7C42_08405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="6399" checksum="05F130E5A03BACA2" modified="2017-10-25" version="1">MIAGLLAEYLERSPDDFDVRAAAGAIAGAGIAVSLRSPVNAENLGRVMEFLDAGMPLGAGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSY8</accession>
    <name>A0A231GSY8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000076">
        <property type="protein sequence ID" value="OXR39736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39736">
        <property type="protein sequence ID" value="OXR39736"/>
        <property type="gene ID" value="B7C42_08197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="85" mass="9771" checksum="0190DEB82BC98666" modified="2017-10-25" version="1">MSTDELPADVREAVRYLAENARLSGYFKWNEEAKLKADMMNVRRRWGRHRVSPDALKRECEAAGLDSEAVTRFSICSPRLRTVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT48</accession>
    <name>A0A231GT48_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000064">
        <property type="protein sequence ID" value="OXR39796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39796">
        <property type="protein sequence ID" value="OXR39796"/>
        <property type="gene ID" value="B7C42_08136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="52" mass="5474" checksum="D882D46AD1539E38" modified="2017-10-25" version="1">MVPGERVGSVKEAVMVSPWRVRVIVGSTLAPFIRVTGNETDSRSGVDSSTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTE5</accession>
    <name>A0A231GTE5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000058">
        <property type="protein sequence ID" value="OXR39848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39848">
        <property type="protein sequence ID" value="OXR39848"/>
        <property type="gene ID" value="B7C42_08089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="43"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="33302" checksum="EFE93E357B550B32" modified="2017-10-25" version="1">MTAHAAPDDILAVLKTACAQAGFDAMDAELLNRSENAIFRLPGKRVARISRPGQHAAAEREVRIARWLEASGVSAVQAAADVVQPVEVDGRSVTFWKELPPHHHGTPAQVAAALKQLHALAPPADFTLGKVEPFVRLEERIMTATVLSEDDRRWMVGHLAELRERWIQLPEGLPWCVIHGDAWVGNVVATDDGRVILLDLERTAIGPPEWDLVHTAIKWSSFGWISAKQYAEFCDVYGCDVTNWAGFELLRDIREFRMTTMATQSAVGNPAWRRQSAHRLACIQGHFGARPWEGWRALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTT9</accession>
    <name>A0A231GTT9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782739.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40026">
        <property type="protein sequence ID" value="OXR40026"/>
        <property type="gene ID" value="B7C42_07910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="94" mass="9586" checksum="2FBC1A9B1A1435E3" modified="2017-10-25" version="1">MTYGVVDSIAVLAQQIPITPEAPPGSAGLTKVVNWLAWAVMLAGIAALIYAGGKFGWERWHGGAVESPKIVLGALVGGIIATSAGSIMTQIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU93</accession>
    <name>A0A231GU93_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776358.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40189">
        <property type="protein sequence ID" value="OXR40189"/>
        <property type="gene ID" value="B7C42_07703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="151" mass="16262" checksum="47BC121363D5F2B9" modified="2017-10-25" version="1">MALKDLRFEVPFNVAFERGLVLVGEIEPDTEYNQNRNAPARQKVDPVTGLRQWKATCTNPAETNHKKSTIQVIFLADVAPIPSTEEVLPGMRSIVLENVTLQPKVTGQGEFKTLGWTVRATGIVGDNSGAKVPAADPGAARPARGQSDKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUF4</accession>
    <name>A0A231GUF4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40259">
        <property type="protein sequence ID" value="OXR40259"/>
        <property type="gene ID" value="B7C42_07684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11874" checksum="1E2FF932D3010D72" modified="2017-10-25" version="1">MNAVNREPAIKRRHPADDIPDKPAGPQSEPKAQTTNKKSAPVSVPAPAVPLDERLIEQHNVRIRPSTKARLKRAVDKLRYETGDRTISEASLTDRALLEFLERNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV70</accession>
    <name>A0A231GV70_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40496">
        <property type="protein sequence ID" value="OXR40496"/>
        <property type="gene ID" value="B7C42_07435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="96" mass="10763" checksum="7F55FE1ABE7CC29E" modified="2017-10-25" version="1">MQPDGPPTIPTDYVTRQSTRIIANGHRDYRADSITQPDNAFPFPFPDPGNPMLEYLVRKAKELDETEGQPPYVWLAVHAWYEGALSTLADPPKSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVK4</accession>
    <name>A0A231GVK4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909791.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40618">
        <property type="protein sequence ID" value="OXR40618"/>
        <property type="gene ID" value="B7C42_07303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="144"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="602" mass="67128" checksum="F115F4D9A490C682" modified="2017-10-25" version="1">MVDEVDGESRVPDQRQWRAEHRYRAVREVLDGAPVAEVARQYGTSRQALHTWLRRFEADGQAGLVERSRRPKTSPTRLPAELESMICEMRRVHPRWGAQRIAHELAVRGVAEAPSRSTVYRVLVRNSLVQHQEQNHRRSYRRWQREAPMQLWQLDIMGGLFIADGREAKLVTGIDDHSRFIVIAQVIVEQSGRAVCQAFTEAMNRYGVPAEVLTDNGKQFTGRFTKPFPVEVMFERICRENGILQRHTKPRSPTTTGKIERFHGSLRRELLDDCGPFESLAAAQRAIDAWTHVYNHSRPHQALKMATPFSVFRPVPGIEPPQEPAVTEPPRVPLPQPRFHDEDTSIETQPVELDMVISPAGRLCLPGAKSDMKFPAALGGHPVTVWAGMHSIHVTLAGEIIRTRQSRLTVEDLAVLRLRGRPAGPEPSGSAVPRGAVPTGTAVEIDRIVTRDGDVTVAGQRLKLGIYLSGQQVTLRLDRHLAHVIADGHLVKTLPSPISPEQASRLNGSRAVTGPLPPARQGAIKLIRTIPADGITQVAGQRLRVGRAHAGKTVVVLAEDTVFRVLHNDIEISTHVRKSDKRITYLRATRRPRGKDVPNPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVQ3</accession>
    <name>A0A231GVQ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Insertion element uncharacterized 12.0 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40645">
        <property type="protein sequence ID" value="OXR40645"/>
        <property type="gene ID" value="B7C42_07330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11947" checksum="D5841BBE9BE1BF8D" modified="2017-10-25" version="1">MSSSKKYPQELRERAVRMFAEIKGEHESEWAAMKAVADLLGVGTPETVRKWVRQGQIDTGNRAGTSSDEMAELKRLRRENAELKRANAILKAASAFFAAEIDRPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVW2</accession>
    <name>A0A231GVW2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063008111.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40760">
        <property type="protein sequence ID" value="OXR40760"/>
        <property type="gene ID" value="B7C42_07184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="11588" checksum="52D1FB2B45758183" modified="2017-10-25" version="1">MTDVCIDPATAQQAGVDISTNSNESRTRVEQQFDEIEPARQANEGWQTGPALVDFASARKQDILSSLAELESIGKKIVEIVSARTSVDERYATSLGRIGKAVDSMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWJ5</accession>
    <name>A0A231GWJ5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE_4</name>
        <name evidence="10" type="ORF">B7C42_06960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779432.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40994">
        <property type="protein sequence ID" value="OXR40994"/>
        <property type="gene ID" value="B7C42_06960"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="34608" checksum="8195BEF09F4DC317" modified="2017-10-25" version="1">MKLLVTGGAGYVGGVCAQVLVQDGHEVVVVDDLSTGNAEGVPAGAKFVDGDIATTGVELIESESFDGVLHFAAQSLVGESVQQPEKYWYGNVVKTLALLEAIRRTQTPRLVFSSTAAVYGEPEQVPIVESAPPRPTNPYGASKLAIDHAITSYAVAHGLAATSLRYFNVAGAYGGLGENRVVETHLIPLILQTALGHRDSISVFGTDYPTPDGTAVRDYIHIRDLARAHVLALAQSRPGEHRIFNLGSGTGFSVREVISACERVVGRPIPAVDAPRRAGDPAVLIASSAKAIDELGWQPEHNDLDEIVSDAWEFLTSLGDRAHSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWJ9</accession>
    <name>A0A231GWJ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-(1-&gt;3)-arabinofuranosyltransferase</fullName>
            <ecNumber evidence="9">2.4.2.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_06911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.47" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40945">
        <property type="protein sequence ID" value="OXR40945"/>
        <property type="gene ID" value="B7C42_06911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="481" mass="54168" checksum="E4A5FDBD34DB11EE" modified="2017-10-25" version="1">MRGRTKWRGTLPAKAVSRAPDGGSAQPSPRFPVYRAPVFLRQLEPRTARTTAEVFNFALWPFAILTVLHQVIVKGTNFSITDDFAPVYKASLAFLNGRAIYGENFDLVDPHYLYPPSGTLLIAPLALIDPEKSRWCFIALNAVAIILAWYLLLRLFKYSTKSVAAPLLLLLMFASETVMNTLGFGNVNGCLLLAEVLFIHLLLQRRDLLAGLVMGLTIAVKPTLAPMLLIPLARRQWQVFITAIGVPVVLMAVAWPLTKDPMDFVHRTLPYLLKSRDYFNSAIAGNAEYYGLPMWLTWGMRITLGVLVLISLWLLYRYCRDDELFFVCTTAGIILIASWLLSGLGQQYYSMMLFPFLMTVVLRNSVLRNWPAWLAIFGFMTYDKWLLDHWQSTGRALEYLRVTFGWALLLIVTFCVLGDRYLAARREGRLDSGIEPAFLLPKETTTPAAPAEPAPRIERHETVPDDDTMDPTAQSEAGALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWN3</accession>
    <name>A0A231GWN3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acuC</name>
        <name evidence="6" type="ORF">B7C42_06958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40992">
        <property type="protein sequence ID" value="OXR40992"/>
        <property type="gene ID" value="B7C42_06958"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01272">
        <property type="entry name" value="ACUCPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="5">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="410" mass="43699" checksum="774674C37617A474" modified="2017-10-25" version="1">MADDAAVVWTDRFLDYTWTPEHPMKPARLRFTMALARSLGLLDGIETLAPAPAGDGELLRIHTPAYLEAVRHAVPAPPGTTPSAAPPHGLGSMDNPVFPHMHEAASVIVGGTLAAAAEIAAGRARRAVSIGGGMHHAMPDAASGFCVYNDVAVAISWLLDNGFDRIAYVDVDVHHGDGVQRAFYDDPRVLTISLHQHPATLWPNTGWPEEIGAGPAEGTAINLPVLPGTRDAQWLRGFHAVVPGALAAFRPQLVVSQCGVDSHREDPLADLELTVDGQRAAFRAMRELADRYAEGRWLAVGGGGYGLVRVVPRAWTHLLATALDREIDPGTAIPEDWRELVRGYAPTVSAPTTMGDGGDTAFLPWEGPGGALDTGDAHLDRAQRAIDTSVLATRRATYGLLGLDPEDPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWX1</accession>
    <name>A0A231GWX1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione-independent formaldehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fdhA</name>
        <name evidence="4" type="ORF">B7C42_06869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.46" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036511242.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41099">
        <property type="protein sequence ID" value="OXR41099"/>
        <property type="gene ID" value="B7C42_06869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018467">
        <property type="term" value="F:formaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="188"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="379" mass="41568" checksum="7ACA6E56A3EF2EA8" modified="2017-10-25" version="1">MKALVYDGPRQVHVKDVPDARIEQPTDVLVKITSTNICGSDLHMYEGRTDLEPGMVLGHENLGIVAEVGNAVVKVTTGDRVCLPFNIGCGFCRNCEEGLTAFCLTVHPDPKMAGAAYGFAGMGPFWGGQAEYLRVPFGDFNCLRLPEDAQDKENDYVMLSDIFPTGWHCTRLADMQPGDSMVVYGAGPVGLMAAYSAMIQGASKVMIVDRHPDRLRLAEQIGVIPIDDSKGDPVEQVLEQTNGRGADKGCECVGYQAHDPQGHEDSAMTMNRLVDSVRFTGHIGVVGIFLPQDPNAPDKLEKKGRIAFDMGKFWFKGQKAGTGQANVKHYNRQLRDLIHEGRAKPSWIVSHELPLAEAESGYQHFDARDDGWTKVVMHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX11</accession>
    <name>A0A231GX11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41051">
        <property type="protein sequence ID" value="OXR41051"/>
        <property type="gene ID" value="B7C42_06821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025350">
        <property type="entry name" value="DUF4254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14063">
        <property type="entry name" value="DUF4254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="18527" checksum="87A74145390E1960" modified="2017-10-25" version="1">MTGDLPDTEGARVATVSPLLVLEGGGAEVIGELPTAEMLLRMVRDSRPAAHPLDPLARQLAELHTGAAQSHDAEYRRAADVSRRETVRVIDRWIEAHVPQHRHGTAIHTETVGSVIDRLMAAYARAAHLLETATDDLAVHAAWFRVAELVNGFDDLAAAITHGERRLPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX66</accession>
    <name>A0A231GX66_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative N-methylproline demethylase</fullName>
            <ecNumber evidence="4">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">stcD</name>
        <name evidence="4" type="ORF">B7C42_06612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41214">
        <property type="protein sequence ID" value="OXR41214"/>
        <property type="gene ID" value="B7C42_06612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="7"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="387"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="647" mass="69542" checksum="8E494ACE4F814DA0" modified="2017-10-25" version="1">MTEFPLLFSPLEVGPLTLKNRIVNAPHQTGFARDKGYSPQLVEYHRERARGGAALIMSQATSVVPGYLDLHNVSDEIIPQYAEVVAAVGEFDAHYGVELYHPGSQGSYEGRGTDVYVGPSAVAADYFHAGWRVPHALVEGEILAIVDAFGAAARRCGEAGVSTVEIHFGHGNLVEQFISPRTNQRTDDWGGPLENRLRFGELILRSVRDAVGPGVAIGARMTATGLDADDPGVMDSAEIIGTVGSWGLLDYVSLTMGRYSDAMNTARNVPNMTFPPGVWQRYGRSIKAVLDIPTFLVGRVNHPRTAEEMLEAGSCDAVTMVRALIADPFLPEKSRTGRVHQIRPCVGAMNCLQRLDQGRGIRCIHNPAVGHEGDLSESVGTSAAPRKVVVVGAGPAGLEYARVASRRGHEVTVVEQSKIGGQALTASQAPTRSELSSITDWLHQQCLENGVEFHTDTTASVESVHALSPDVVAVATGSYLPANPFAGGALRTIEAADVLSTKTFDGRIAVYDSFGDWQGISLSHALAQRGAGVVYVSPTPYPGSALEMTNWRIEYEKLVEAGVEFHPITQVIGVESEALLVKVGFAKNETRIGDLDALVWIGPPVARDGLYHRLQGNGFRVDLIGDAYAPRGIEQSIYEARHAALQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX78</accession>
    <name>A0A231GX78_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782446.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41188">
        <property type="protein sequence ID" value="OXR41188"/>
        <property type="gene ID" value="B7C42_06784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="10569" checksum="EC204984565D10A4" modified="2017-10-25" version="1">MLDIDDPDDVIAVSGQVAAATFSFADQVGATTGGWTVDERPAAPLDFRLKGVFDQVTGWFETAATDLRGRTHATHTRAHGTATGLKNADIDGGGHVQSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXC2</accession>
    <name>A0A231GXC2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase</fullName>
            <ecNumber evidence="7">2.3.1.174</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">paaJ_5</name>
        <name evidence="7" type="ORF">B7C42_06636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41238">
        <property type="protein sequence ID" value="OXR41238"/>
        <property type="gene ID" value="B7C42_06636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="283"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="42240" checksum="D2037B5430D1572A" modified="2017-10-25" version="1">MTEAVIVSTARSPTGRAGKGTLTGIRPDDLATQIIRAALDKIPALDPASIEDIYVGAWEHTGEQGENIARRIAVQLGLDTVPGATVNRACASSVQTTRMAANAIKAGDGDIFVSAGVECVSRYPQQNGVGAGDEAFQNPLFAAAQERTAQLAATGATWTDPRAGGALPDIYITMGQTAENVATHRGISRAEQDEFAARSQQLAEKAIADGFFDREIAPVTLPDGTVVRTDDGPRAGTTVEKLAGLRTVFRESGSVTAGNACPLNDGAAALVIMSDRKAAELGLTPLARVVATAVSGLSPEIMGLGPVEASRRALAKAGLSIGDIDLVEINEAFAAQVIPSYRDLGIDLDRLNVNGGGIALGHPFGATGARITTTLLHALQERDLRFGLETMCIGGGQGMAVIFERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXE2</accession>
    <name>A0A231GXE2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylglucosamine repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagC_4</name>
        <name evidence="1" type="ORF">B7C42_06767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777874.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41171">
        <property type="protein sequence ID" value="OXR41171"/>
        <property type="gene ID" value="B7C42_06767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="29738" checksum="9D27AAD929BE5745" modified="2017-10-25" version="1">MTVLALQIGADGFAACRVADDVEEDDVRRVPIPAAGTWEVCRDLLVEAAEGQDVTAVGIASPGPIDMSAGVVAPVEIPEWRTGFALTQAVGKLFPAANVQIGLDGVCMSLAERNFGATSDVMDALSVLVSDRIAAGVSVGGFSVVGRTGNAGHFGHVLVPGFDDPCECGGRGCVEAVAGGRSLLRWARARGFGGTTVAELNAAAADGDSVATEGLQRAGTALGRAIASVAPLLDFDLVVLGGTVSKAGPALWKPLNAAVATHARIGFLTGLRVIPSEIDDIGVLAGAGVLGIMAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXG5</accession>
    <name>A0A231GXG5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcC_2</name>
        <name evidence="3" type="ORF">B7C42_06676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063001628.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41278">
        <property type="protein sequence ID" value="OXR41278"/>
        <property type="gene ID" value="B7C42_06676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="105" mass="11233" checksum="90B0640710747672" modified="2017-10-25" version="1">MAKVVYHLPDGTTSQVDVDAGQSIMSGSVNNNLPGIVAECGGSCACATCHVFLAPEYQDLFAEPSDEESELIDYLDGATPESRLSCQLIVSDTDREIHVRVADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXM5</accession>
    <name>A0A231GXM5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative enoyl-CoA hydratase echA12</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41315">
        <property type="protein sequence ID" value="OXR41315"/>
        <property type="gene ID" value="B7C42_06713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="29099" checksum="BCB8F9DFCBA48229" modified="2017-10-25" version="1">MTIDFPDLQTLTFEEAEPGIGILRINRPERMNSQTVTMFHEHLAAGRALRDSRLRALIVTGAGERAFCAGFDLEEIQVITEMGVREFLKFQEVATGGIQSIRHLPFPVIAAIHGPATGGGLALALAADIRLAAPTLKMSAAFVKVGLSIGELGTSFNLARLVGPARAAEIGYTARIVEADEALRIGLVNQVVPSERLLDEALAMARVIAQNSPGGVRMSKRAIQRNAEIGSYEAALELENRGQALLTRTEDMPEALAAFKEKRAPQFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXN5</accession>
    <name>A0A231GXN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41281">
        <property type="protein sequence ID" value="OXR41281"/>
        <property type="gene ID" value="B7C42_06679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="7930" checksum="B2B2241340CAD038" modified="2017-10-25" version="1">MALISNGNVVLSRRSFDILNYFGRCPACGYSAEATVTVTTYSDGSSETQLVGRCGLPCGWTGPIEMTTMTTVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY59</accession>
    <name>A0A231GY59_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine efflux pump PbuE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pbuE_3</name>
        <name evidence="8" type="ORF">B7C42_06352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41461">
        <property type="protein sequence ID" value="OXR41461"/>
        <property type="gene ID" value="B7C42_06352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="4"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="40105" checksum="248C9B9B75693DEA" modified="2017-10-25" version="1">MPLVVVVLAVAVFAQGTSEFMVSGLLQQIADDLGVSLGAAGLLTSLFAAGMVVGAPTMAMAAGRVPVRYSATAFLGVFCGAHVIGATATGFAPLLATRGVAAIADAGFLAVVLAALPRLVGPAMIGRATAVVVSGVTVACIAGVPAGTVLGQVWGWRSAFWAVAVLSAVALVPVWTMLGRQGRDSDVPSGPAPSMRREWSVLTQWPVLIAVVAAILVNAATFAAFTYLGAITTAVAGDRWVPVALALFGAGSFLGVTVTGRYSDRHQRRIVLAGTGLLMGVWLVAAVAAHVLIGVMVVSVVAGAVAFGVGSTLIATIVRTATPAAPRIAGALATTALNIGAVLGPVAAGPVVDLTGHPATALWCGAAFTAAAVGVVGLDRRRPATSPSSSGIADRPAARRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY60</accession>
    <name>A0A231GY60_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41515">
        <property type="protein sequence ID" value="OXR41515"/>
        <property type="gene ID" value="B7C42_06407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="308"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="43065" checksum="7EAB57C5D0FE158E" modified="2017-10-25" version="1">MAADTTSTPVDPDAGRARTTVGPAEDRITRLFARFLSSGYVAYLFLMAATIVSQADDLALWWTVLAVGLVYGPAVVMGLFSFHPDLRWVRATAAVTALGFVVAAALWPVAWNGELLRADAWISTIPGLAGLSAALVWPAGRTVAVLLAAVIPVQLINHLCRAPGHNGRFVPDLLFAISFCLLFVAAGLMAMRTGRILDATRNEAHEAAAAAAAATARTVQRARFNALLHDWVMSTLLAAARGTQRSEVRHQAELALGKLNDVGSEGAQGFTAVTAAAHIRTAVADVDDRLPVTVREDPDGGDRYFPAEPIQVLGAAVAEAVRNSVIHAGAHAARTVSLRFDEGRITVVVTDDGRGFDPAKVPSHRLGLAVSIVERVRRLPGGEVEVRSRPGAGTRIHLSWRAVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY71</accession>
    <name>A0A231GY71_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41538">
        <property type="protein sequence ID" value="OXR41538"/>
        <property type="gene ID" value="B7C42_06430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="211" mass="23109" checksum="82F657F4387EBF50" modified="2017-10-25" version="1">MTTPYDRNDGVMTSTDTDTTVLREHTVAERRRLADLLAGLTPEQWAAPSLCEGWRVREVLAHMTMPYRTSTWSFVRGLAGARFSFHRYADRAARADTARMSDAELLASLRDNVEHPWRPPGGGVVGALSHDVIHGLDITEPLGLPPAPPERIAIVLDRASPKSLRYFGVDLNGRQLRATDAPVTLGSGTPTTMCAKDILLTVTGRRPLAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ6</accession>
    <name>A0A231GYJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein Stp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">stp_12</name>
        <name evidence="7" type="ORF">B7C42_06335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41694">
        <property type="protein sequence ID" value="OXR41694"/>
        <property type="gene ID" value="B7C42_06335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="467" mass="48257" checksum="B7DC422E7A848CCD" modified="2017-10-25" version="1">MTAAPAETAPVRSDPFTARFVGPLLLGSTLNPINTSTIATALVGIGVDFHRGPGTTAVLISVLYLCSAVAQPTMGKLATLFGPRRVFTSGLIILIAAGVIGAAAPAFEFLVVSRALIGIGTSAAFPTAMALVRRRADDAGTGVPARVLGNFSIAAQVTSVVGLPLGGLLAGVFGWRAIFFVNIPLALVALVATLAGVPKDEPRRRDQGSLPAAIDIVGIGLFAGAVIGMLTFLSNLRSPLWWLLPVTLALAATLVAWEWRARSPLIDVRMLTRNGGLLRTYARQAVVSLGTYTALYGTSQWMEQAAHYSASQVGLILLPLSAISIVIARLVSNRGWVRVPLAASGAALIATGLVMVVITHDSPVIVLIAMSLLFGVASGASGFANQAALYVQAPARQVAVASGLYRTFAYMGAIFSSSLIALTFGSATTDAGLHAIAWVIAGLGVVVALMTLLDTTIPVRTGKASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYP1</accession>
    <name>A0A231GYP1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41727">
        <property type="protein sequence ID" value="OXR41727"/>
        <property type="gene ID" value="B7C42_06069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="237" mass="25350" checksum="15EA782B843F1AC4" modified="2017-10-25" version="1">MSATPVPRPALSPTRRSTVTRYRDRAATDRAALDDVLDAGLICHIGVLLHGAPVVLPTIYGRVNDTLYLHGSTGAGNMRAALTGEISVAVTLVDAIVYARAAMHFSMNYRSAVIHGRPVEVTDPEERLRALRAIVEHSAPGAWDTVRAPDKKELAATLVLALDLTEASVKTRTGDPSDDPADLNSDAWAGLLPVRYAFGTPIPAPDLVRPVAVPDHVVARIRTGEFAETEGAISPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYV1</accession>
    <name>A0A231GYV1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783008.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41787">
        <property type="protein sequence ID" value="OXR41787"/>
        <property type="gene ID" value="B7C42_06129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15196" checksum="B779804DA37DF737" modified="2017-10-25" version="1">MSGAQVVFGAGELAVVALAGVSLVAASRLARSYRIAGWSLAAAAVVWLVAEGVRLVQLEAVLPALPGPDHESARMLVTLLGDTVYFGLGGAGVLLLFFAAVVERASRGDGRREPVALARRIGAQAWHYYRARDQRERSRRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ63</accession>
    <name>A0A231GZ63_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41862">
        <property type="protein sequence ID" value="OXR41862"/>
        <property type="gene ID" value="B7C42_06204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="151" mass="17207" checksum="9FD2B01D4738DDE3" modified="2017-10-25" version="1">MSDDFVPQTNNSRQIFDVFAEIGSLPETSESMLTDVYFSDFPHASSRIFRIYRTLPLHYHNDCDEHLYVVSGEGVFHLDGSESRARPGTFLRFARTQVHGFPTITTHPFVVLSIDVPRRRPDDIVFVDPENGDPRAFMARNNVQGRKFSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZT3</accession>
    <name>A0A231GZT3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42118">
        <property type="protein sequence ID" value="OXR42118"/>
        <property type="gene ID" value="B7C42_05717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850514" description="SGNH_hydro domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="218"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="435" mass="45145" checksum="B25525D1F25C13FC" modified="2017-10-25" version="1">MVVGKWLGAIAGAALVWTGSIATGVGAADPVAGCGDSHWVGSWMAAPSDSFSAADPALIPQLSVSDQTYRLVITPHRGGSVLRVHLTNRTRPVPMEVDHVTIGVRSGGAALQPGSLRTVTFDGKSAVTMAPWSDAVSDPVELPFPAWQPLSISVHAPGLAVLPTEHFDANATSYYSPPFAGDHTTDVTGSQLKLSTTAMPFVSGLDVQAPGNASAIVAFGDSITDGYVSSTVLGTPQDASVVDRNVRYPDFLQRRLDAAGAPFTVLDAGISGNRVTRAGFIPQFGPAAVDRVQRDVIDQAGVSDAIVLEGINDLGIPIGASDEQVVAGYTDLITRLHAAGVKVHLATLLPASNALADGILTLPNADATRQRINAWIRGQHLSDTVIDLDAALRDPAAPNTLAPGFSGPDNLHPNPAGYRAMADAIDLASFHGVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZY7</accession>
    <name>A0A231GZY7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigJ_7</name>
        <name evidence="8" type="ORF">B7C42_05711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42112">
        <property type="protein sequence ID" value="OXR42112"/>
        <property type="gene ID" value="B7C42_05711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="133"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="37025" checksum="DF13B48846C0B20B" modified="2017-10-25" version="1">MIRRDQDRWLGWTRPICLADDIGMLLTREADVFESFRPRLEAIAYRLLGSASDAEDAVQETYLRWQAADREYVRTPEAWLTKVLTNLCLNQLGTARARRETYVGQWLPEPVLAGDSMLGPADTVEQRESVSIAMLTLMERLTAKERVVYVLREAFGYPHHEIAELIDITEANCQQVYRRAKQHLSMERARIEVDEAAARRIVREFLAAAASGQTEALVALLTDDASIIGDGGGFLATLSRPLVGAPRIARFVCLAIKPSNGTWNKLGGKPEMFAAIANGMPALVLVSDDRVVGIVVLQVTVDGIAAVHAHVNPDKLAYANRQWATRAPGAPLPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H063</accession>
    <name>A0A231H063_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent stearoyl-CoA 9-desaturase</fullName>
            <ecNumber evidence="2">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">desA3_4</name>
        <name evidence="2" type="ORF">B7C42_05811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42212">
        <property type="protein sequence ID" value="OXR42212"/>
        <property type="gene ID" value="B7C42_05811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="413" mass="47450" checksum="B79F5715D21F5606" modified="2017-10-25" version="1">MAITDIDAYAHLTPEDIEALGAELDTIRRDIEESRGERDARYIHRTIALQRALAAGGRVTLMFSNRKVAWLAGTAMLGLAKIIENMELGHNVMHGQWDWMNDPEIHSSSWEWDTTCPSVQWKHSHNFVHHKYTNVVGKDDDVGYGILRVTRDQRWEWWNIGNPVYNLALGTLFEWGVALHHLEVEKIRRKDKTWRQAFRDLRIIGTKVVKQAAKDYLIYPALSGRNWKTTLTADATANLIRNYWAYMVIFCGHFPDGAEKFTTEELAEEDQPRWYLRQMLGSANFRAGPLMRFMSGNLSHQIEHHLFPDLPSNRYEEIGVRVRELCDKYDLPYTTGSLGRQYLQSFRTIAKLALPNALLTATSDDAPETASELRFAIRDGMRAHFGVDPETGKRRGLRTALRELKQAPVRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H080</accession>
    <name>A0A231H080_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42151">
        <property type="protein sequence ID" value="OXR42151"/>
        <property type="gene ID" value="B7C42_05750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="49" mass="5355" checksum="85E5D6365B3B1DCB" modified="2017-10-25" version="1">MTTAEELSAFAPLASLDRGKLDTLARAGRSVRYCAGQRLITEGRRADRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H090</accession>
    <name>A0A231H090_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional ligase/repressor BirA</fullName>
            <ecNumber evidence="6">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">birA_3</name>
        <name evidence="6" type="ORF">B7C42_05466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42267">
        <property type="protein sequence ID" value="OXR42267"/>
        <property type="gene ID" value="B7C42_05466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH_11" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="5">
        <location>
            <begin position="169"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="317" mass="34709" checksum="94DA26E42543F9A9" modified="2017-10-25" version="1">MTSTTTRVLRLLSLLQDRTYTGRELAQRLDVSDRTLRQDIARLRELGYPVHAERGAVGGYRIGQGKTMPPLLLDDDEAVAVAVAIGLAEDGSTGIADIDQNVTRALAKLERILPVRLQRKVTALRTATEIGPATTGSREPDAPVPAQTLTTIASAIRGTRILTVDGGLLEPYRLINWQRRWYLVAYDLETHCWRALPVAAVDSVASGYRHFASRPLPADDLVAFVLREIATAGWRVHARVTVLAPAETVIARINPAVGVVEPVDAQSCVLYTGADTLETIAIYLSMLMMDFRVDGPPELVDHIRTLGRRYSSAVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0C1</accession>
    <name>A0A231H0C1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42299">
        <property type="protein sequence ID" value="OXR42299"/>
        <property type="gene ID" value="B7C42_05498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="21673" checksum="27BDC4CD19D66E0E" modified="2017-10-25" version="1">MSEMRTGPGGATKVAGTPVPYVTYAEFGRRFVAYAASEQRIAAVFGQLAGSAFDFGPIGVGPAHLAKASAQVQLGDPVLERSVGEVVGFELAIPLDIDLLLDLAVDRHRFEVTGFVHVHLTVRTAAPLRIVIDIAEPHPGDVRIDVATATRRGQLLRLLASVDHEIRRFVARYVANEIRKPHIAAVRDIDVAARLDAAWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0P7</accession>
    <name>A0A231H0P7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosyl-[dinitrogen reductase] glycohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">draG_2</name>
        <name evidence="1" type="ORF">B7C42_05607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.24" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42406">
        <property type="protein sequence ID" value="OXR42406"/>
        <property type="gene ID" value="B7C42_05607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047407">
        <property type="term" value="F:ADP-ribosyl-[dinitrogen reductase] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="38648" checksum="BF87916BD6043986" modified="2017-10-25" version="1">MAVQDYTTIFDRYRGTLLGGAVGDALGWPIEFLKLDQIRDRFGPDGLTGFAPAADESTPRQITDDTQMTLFTAEGLLRCAPGADPAPALRRAYLRWLRTQREHAPDPRPDGWLAGLPYLYAVRAPGNACMRGLNRQAQSYREPHPVGVPGPVNEDSKGCGTVMRSAPFGLAALGPEAAFQASARCAQLTHGHPTGYLAAGAFAALIDRLVNGADLRTAVQDTTSQVEAVAGGAETAAALRKAVATADAGAGTSEGVEQVGAGWVAEECLAVGVYCALDAERTGDVRRAFLLSVNHSGDSDSTGAVAGNILGARHGLDALPLDWCGAVEGRDDLARVADDLVAAFVYRDRNPLGDRYPVDAPEDPVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0W3</accession>
    <name>A0A231H0W3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42514">
        <property type="protein sequence ID" value="OXR42514"/>
        <property type="gene ID" value="B7C42_05290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9416" checksum="57306B8C1F4019BF" modified="2017-10-25" version="1">MPGLLRGVARTAVVAGTATAVSNRVSRRQGQRWAAQQEYQYEQQPPPPAPAGGGTDRIAALKQLGELKAQGVLTEQEFESEKARILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H127</accession>
    <name>A0A231H127_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative response regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778101.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42501">
        <property type="protein sequence ID" value="OXR42501"/>
        <property type="gene ID" value="B7C42_05277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="14215" checksum="08177DFE287FCF05" modified="2017-10-25" version="1">MADANRPALRVLVYSSDADTRRQVMLALGKHPHPDLPPFDYHETATAPVVIEQLDAGAIDLAILDGEATPTGGMGLAKQLKDEIADCPPIVVLTGRADDAWLAAWSRAEAAAAHPLDPFQLTSAVTTALNARPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Z1</accession>
    <name>A0A231H1Z1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42858">
        <property type="protein sequence ID" value="OXR42858"/>
        <property type="gene ID" value="B7C42_05196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="15962" checksum="B6E0CDC64C9D88D5" modified="2017-10-25" version="1">MAMIPTDDLPTPTADVLRRRARAAGLSMNAHIRGELIGLAGRRIPLDAVVEFLDAERPGRHDSAIDADAMAVIGDYDLPAQTWSVLARRAGAAGMPLSAYIRQELITSARRTTVNDVALEMLEVQQANPGLVIDMDAVVAATRYVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H274</accession>
    <name>A0A231H274_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42927">
        <property type="protein sequence ID" value="OXR42927"/>
        <property type="gene ID" value="B7C42_04813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="24615" checksum="3BD4C41F62067D42" modified="2017-10-25" version="1">MDGRSTRWNGHKQRRRAEVIEAAVAVIEENGAEVSVQQIADRLGLPRPVVYRHFDGRTDLDEQIRGRILESLLTQLLPTLRADGTVKDAVRGAVGTYVGWVDSHPQLHRFLAASAPQGDSSLALAGARDRIGARLADLFATAAARVGIDPVRARPMAFGIVGFVDGVVNSWRADTASALGSEQIEAIVTESVLGLLESNARSLGVPLDRDATVADLVARSEAAAPDPLAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2A0</accession>
    <name>A0A231H2A0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase EstB</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">estB_5</name>
        <name evidence="2" type="ORF">B7C42_04856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42970">
        <property type="protein sequence ID" value="OXR42970"/>
        <property type="gene ID" value="B7C42_04856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="383" mass="40862" checksum="B6D6C852361E74C0" modified="2017-10-25" version="1">MTGVRGWVDPAFEAVREVFAANLAEGRDLGASVAVCVDGRPVVDLWGGVADERTGRSWEQDTACVVFSCTKALTATAALAVAQDVGIDPDEPVARWWPEYAVAGKESTTLTDMLTHRAGLPVFERPITAAEAADPELMARTLAAQRPIWRPGGEHGYHALTFGWLVGEFVRRHTQSTVGEYVRGHFGADLRIGISADEAAQAARLARPPATEMVWTDDSGPIDAAAAARLAEAYRDPDSLLMRSSSNPAAAYNNSEVLAGGWPASGLVVTARALAGFYRDLVAGTLLPRAVLAEATRERVRGVDTVLQLETALGWGYMLPSQNFVLPDTAAPTAFGHPGAGGSIGMGDVDNRVAIAFVPNLRRDWFAGDRRAYDLVAAVYDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2H8</accession>
    <name>A0A231H2H8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferric enterobactin transport system permease protein FepG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fepG</name>
        <name evidence="9" type="ORF">B7C42_04942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43056">
        <property type="protein sequence ID" value="OXR43056"/>
        <property type="gene ID" value="B7C42_04942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="39303" checksum="48E41AD67931CF60" modified="2017-10-25" version="1">MNARSDIRTTDAAGTESNTETASGSVGDSRSAPDVGRSGAELTQVRPAVRIAGMSAVLRLSMLLTLLALAAAIVVLFVVDISVGDYHIALGRVLDVLTGGGTRSQRYVVMESRLPRAVTALVAGAALGIAGAITQSILHNPLASPDVLGITSGASFAAVAVLAGVGGTATGIVASLGVPLAALAGGLATAALIGVLALGRNSGGGSGLSGMRFILIGIGVNALLLAGINWLVTRASLDDATRAQLWLTGSLNGADWNRTAAAAAGLVVVVAIAAGSARTLAALRFGSDTTRALGVRVQTQQLVLIGAAVAAAALATAAVGPLGFVGLAAPQIARRLLRTPGEPVIGSALTGALIVVAADVAARTVVPVDLPVGLVTAAFGGPFLLLLLIRVNRKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H325</accession>
    <name>A0A231H325_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_17</name>
        <name evidence="5" type="ORF">B7C42_04705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43283">
        <property type="protein sequence ID" value="OXR43283"/>
        <property type="gene ID" value="B7C42_04705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="216" mass="23875" checksum="93E5D8663A77DD75" modified="2017-10-25" version="1">MTGGSGKTAESVVSGGRHLRRVANPARQVRYDEEVKTLIRSAQEVMRRKGRTEMPTVAEIVREAGVTNQAFYRHFRSRDDVIVATYEQGLLTLHSYLEHQVSKCSGAHDRIRAWIEGVLAQIEDSRLSQLSAVILWNVGQVARAESEIEPVGFARMLHLLDTVLADGGVADHERAALFVQTLVLGMTSRYHDSGTVPTAADREHLVRFCLDGIGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3D7</accession>
    <name>A0A231H3D7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036510789.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43375">
        <property type="protein sequence ID" value="OXR43375"/>
        <property type="gene ID" value="B7C42_04242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="81" mass="8686" checksum="F81C42229A6F7004" modified="2017-10-25" version="1">MSDHNSGPREGIKGVVEDVKGKAKEAAGIVTGNNDLESEGRAQQDKAESQREAAEKEAQAERARAEAKVDEARQQSHQQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H402</accession>
    <name>A0A231H402_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_04442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43574">
        <property type="protein sequence ID" value="OXR43574"/>
        <property type="gene ID" value="B7C42_04442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="161"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="264"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="444" mass="47564" checksum="B8BF1032C7CE2A26" modified="2017-10-25" version="1">MVGDAPRLVARDVLRAVRERDAYANLVLPVLLREYGLSGRDAAFATELAYGSCRAMGVLDAVIAECAGRPIAEIDGPLLDVLRLGVYQLLRTRVGSHAAVDTSVDLVRTESGSGKAGFVNAVLRRSAARTPEQWVEDLAPADPIGRMAFEFGHPVWIAQAFADALGARAGELRALLAADDERPIVHLVARPGDITAEELALVSGGEEGRWSPYAVYLDSGDPGQLEAVREGMAAVQDEGSQLVALSLTRAPLLGEDGGRWLDLCAGPGGKTALLGALADIDRYRVDAVEPAEHRADLVRKATRGLPVTVHVVDGRDSGLEPGYDRILVDAPCTGLGALRRRPEARWRRTPADVRDLTTLQSQLLTAAWDLLRPGGVVVYSTCSPHLAETISVVSDFVRRRDAEQLDTHALLPGVTDTGDGPAAQLWPHRHGTDAMFMAALRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4B9</accession>
    <name>A0A231H4B9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xanthine dehydrogenase subunit A</fullName>
            <ecNumber evidence="3">1.17.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pucA_3</name>
        <name evidence="3" type="ORF">B7C42_03949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43714">
        <property type="protein sequence ID" value="OXR43714"/>
        <property type="gene ID" value="B7C42_03949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="167"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="35268" checksum="E4FA801E934434D3" modified="2017-10-25" version="1">MRDIVEDLLRVWHSGRTGGLATLVRTFGSSPLPVGSAMLVDPDGGVHGSVSDGCYEAAVYEAAVEAARTGHRELRRFDATSGFEVSAECGTIDVFVEPFSRNDFPEFAAVAGDIARHKPVTVFTVVWHSDPEVIGQHLVTDRRHNTELVSLPESDVFVSSHTAPPRLIIFGANSFAAALTTQARLLGYRVTICDPREAFAVPASFPGAEVVVDWPHRYLNAQAGAGNIDRTTAIVAATQDPKFEIPLLTVALRLPELGYLGALGSHSAHDHRLEALQAGGFGADTLARLHAPAGFDIGARTPMEHAVAIAAELLAVRSAGSSRTPAHATAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4I4</accession>
    <name>A0A231H4I4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative trans-acting enoyl reductase</fullName>
            <ecNumber evidence="3">1.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43738">
        <property type="protein sequence ID" value="OXR43738"/>
        <property type="gene ID" value="B7C42_03973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="2">
        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="415" mass="43530" checksum="1E91C783915D130B" modified="2017-10-25" version="1">MGMTDREFDLVLFGATGFVGRLTAQYLAEAAPANARIALAGRSPEKLTAVRDELGGAAAIWPLLVADSSDQAALDALAARTKVVVTTVGPYLRYGLPLAQACANAGTHYADLTGEPLFIRECIDRFGERAAETGAKIVNSCGYDSIPSDLSVYRLFRRSVEDNTGELTDTTLVAWLKGGASGGTIDSGRAMMEAIATDPAKGSVLSHPYSLSPDKSMEPDVGRQSDQALSRASAIDPSLDGWVATFVMAAHNTKVVRRSNGLLGWVYGKNFRYREVMSAGSSPAAPLVAAGMAGGIVAGLTAGALLSRVSAGRRLLDRILPKPGTGPGEEARRSGWFTMKTFADTTSGARYVCTFAGQGDPGYQATSVMLGEAGLCLAFDELPELAGILTPASAMGDPLTDRLRRAGLTIEVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4N9</accession>
    <name>A0A231H4N9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system</fullName>
            <ecNumber evidence="3">2.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acoC_2</name>
        <name evidence="3" type="ORF">B7C42_03997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43762">
        <property type="protein sequence ID" value="OXR43762"/>
        <property type="gene ID" value="B7C42_03997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172440" evidence="1">
        <location>
            <begin position="35"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="64"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="32712" checksum="DC1DB1A088F25761" modified="2017-10-25" version="1">MRTAAAGRAKRAMLLLVTALTALLVGNTAGVATAAPDDSVDRTVRLPDGDIHVVTSGAPSDRAVVLIHGTGGSVSWWDPVLPALTDFYVVRVDLLGHGRSAKPDSGYGMAEQGHRVGAVLDWLGVRSAIVVGHSTGGYVATELAAQRRDLITAIGLISTGSRLDAFTDNGPLGNLLFVPQIGQPLWPLLPDAAIRYAMSSAFTRDVAIPQQLVDDFHGMTYRSITATSDASDVYLRERREPDRLADLGLPSLVLYGSGDHRWPAASFQDYRNVPGVRIESLDCGHSPMIEEPGPTGELLRDFAEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Q2</accession>
    <name>A0A231H4Q2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43696">
        <property type="protein sequence ID" value="OXR43696"/>
        <property type="gene ID" value="B7C42_03931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="14858" checksum="A822D84A51640653" modified="2017-10-25" version="1">MNITASAISLNVPDPEASATFLSTHFEFTVEMSADGFVSLARPDAGFNVIFLRTGLGTFEPARIAGDAGQGLLVVFTVADIDAEYERVRAEGVEIVTPIETEPWGERYFQAVDPNGIVIQLVQWVGDPSAYDANSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5F2</accession>
    <name>A0A231H5F2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosine kinase</fullName>
            <ecNumber evidence="2">2.7.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adoK</name>
        <name evidence="2" type="ORF">B7C42_03613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44057">
        <property type="protein sequence ID" value="OXR44057"/>
        <property type="gene ID" value="B7C42_03613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="50"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="36597" checksum="57ED74CFFEC28EAD" modified="2017-10-25" version="1">MSRTRYGKADSALDRQGPGFVTIAVSASIATDHLMRFPGKFSDVLLADQLQHVSLSFLVDDLVIRRGGVGGNIAYAMGLLNGNPLLLGAVGPDFGEYRDWLERHGVDCSAVRISETAHTARFVCTTDETMAQIASFYPGAMSEARDISIAEVAENRSLDLVLVGANDPDAMLRHTEECRKLGIPFAADPSQQLARLDGDQALALIDGATYLFTNEYEWGLLLQKTGLSPEEIGRRVGIRVTTLGAKGALIVDGDGVEVNVEVVPELSQVDPTGVGDAFRAGFLTGHTAGLSLQRSAQLGSLTAVLVLETVGTQEWSLDRDDALRRLRGAYGPEAADELGALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5J1</accession>
    <name>A0A231H5J1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_SAV_6107 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44121">
        <property type="protein sequence ID" value="OXR44121"/>
        <property type="gene ID" value="B7C42_03678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040891">
        <property type="entry name" value="HEPN_SAV_6107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18726">
        <property type="entry name" value="HEPN_SAV_6107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_SAV_6107" evidence="1">
        <location>
            <begin position="29"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="15855" checksum="65D111469B2412C8" modified="2017-10-25" version="1">MAGRMDDPRRAGRAGGLLDRADTMVQQAWAEPDPSERLRSAYLAALRGAGAVLAATGADRAPRARSRNAWVLMQQAAPEFVMWSDYFSSFSETRAALEAGLDRAISDTQADEFASRVEAFLRDVEDALAITAARLRPAPGWLADGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5J7</accession>
    <name>A0A231H5J7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pknL_1</name>
        <name evidence="8" type="ORF">B7C42_03665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44108">
        <property type="protein sequence ID" value="OXR44108"/>
        <property type="gene ID" value="B7C42_03665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="392"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="525"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="593"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="655" mass="69087" checksum="D3A48445A93A2DB6" modified="2017-10-25" version="1">MIGQMLDGRYRIDAPIARGGMSMVFRGVDTRLDRPVAIKVMDPKFAGDPQFLTRFEFEARSVAKLKHPSLVAVYDQGIDGEYPFLIMELVEGGTLRELLRERGPMPPHAVRAVAEPVLRAIGVAHAAGLVHRDVKPENVLISDAGEVKIADFGLVRAVAGSNMTSASVILGTAAYLSPEQVTAGNADARSDVYSFGILIFEMLTGRAPFTGDTSLSIAYQRVEKDVPSPSRFIEGVPPEFDELVAHATAREPAHRFADATDMATELHRIATALHLPDYRVPAPRESAEHLSARYRVVQTPAAGPTPTPQPVTEATTRLAAEPSHTRVMTAAHPIPDPEPQRPHQPPHQPPPPPHRPEFVPDRGTSRRRVLIWAAVVVVLALLLGVGGWWLGVGRYSSVPAIAGMTTEQATAKLKDAGFGTTVRDKASDIIPVGGVVGTDPSAGAKVLKGSTVAVLVSSGQPHVPQFQPGQDTKTVNQLIRDAGLTPVDGGEKPSTAPKGSVAQLDPAPGTVLPTGAQVKVYRSKGSQPVKLPDVRGKTVEEAKAALQNAGLTVGDTRTDFDAKVKPGQVAGTDPAAGTQVLSGATVTLIVSDAIQVPDVIGKNAAAARSELEGMGLKVVLNQVFSGDRGTVRVQSPFGGANVAPGSTVTLTVLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5V5</accession>
    <name>A0A231H5V5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hca operon transcriptional activator HcaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hcaR_3</name>
        <name evidence="3" type="ORF">B7C42_03802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44241">
        <property type="protein sequence ID" value="OXR44241"/>
        <property type="gene ID" value="B7C42_03802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="17223" checksum="A996C5E71A75E8E5" modified="2017-10-25" version="1">MDVHGRDLRYFVAVADELNFTRAAEALFISQPALSKQIRALERRIGAPLFDRDGRAVRLTAVGRTLLPHARKLLADWDIARAEVAVISSTEETYEALLNGDGVVLLAVGNVPLIAHEGVVAREVRGIGPSELALAWRRGDSRPLVRGYIDACRSAVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5X2</accession>
    <name>A0A231H5X2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hisC</name>
        <name evidence="5" type="ORF">B7C42_03767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44207">
        <property type="protein sequence ID" value="OXR44207"/>
        <property type="gene ID" value="B7C42_03767"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="38"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="40460" checksum="73C27E1F362ED665" modified="2017-10-25" version="1">MTATADIPGAAATLDDLPLRENLRGKSPYGAPQLAVPVQLNTNENPHPPSRALIDDVAESIRAAAADLHRYPDRDAVALRTDLAAYLTRQTGVAVQTANVWAANGSNEILQQLLQAFGGPGRSALGFVPSYSMHPIISEGIDTEWIEADRNSDFSLDIDYAAAVIADRRPDVVFVTSPNNPTGHSIALADLERLLEAAPGIVVVDEAYGEFSAAPSALGLIDRYPAKLVVSRTMSKAFAFAGGRLGYLVAAPAVIEAMLLVRLPYHLSVVTQAAARAALRHADETLASVAELAAQRERVATALREMGFEVVTSDANFLLFGYFADAPRTWQRYLDEGVLIRDVGIPGYLRTTIGLAAENDEFLRVSEKLVAAEVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6S2</accession>
    <name>A0A231H6S2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44545">
        <property type="protein sequence ID" value="OXR44545"/>
        <property type="gene ID" value="B7C42_03334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="133"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="42894" checksum="DD72E70D3D492335" modified="2017-10-25" version="1">MAANKLVEKEGAGKFFGAGWGVKLSGVALILFLAAIVAVALTMFVGGFTTSKPVYLDAPRAGLVMDKDAKVKIRGVQIGHVSDIAYTGDQARLTLAMDPDQLKMVPANSTVDIRSTTVFGAKYVNFIEPEVPSAQHLQAGATLTAQSVTVEFNTLFQHLTEVLGKIAPEKLNATLTALGTALQGRGDKLGQLLVDSDEYLRDINPSLPDLQRDLQTSVGVTNLYADTAPNLLRTTDNAAVTSKTLVDHKDSLDAVLLNLIGLADTTGAVLKENENGLSTALDLLRPTAELLNEYNPALYCLVEGVAGAIPRANEIFGGTGPWVTLNASFMPGGTPYSYPKDLPKVNATGGPHCEGVLDRKPGSHANYLVTDTTEGRVYTPELSTHLNGPRVFQLLFAGLPGVGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6U6</accession>
    <name>A0A231H6U6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-succinyldiaminopimelate aminotransferase DapC</fullName>
            <ecNumber evidence="2">2.6.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dapC</name>
        <name evidence="2" type="ORF">B7C42_03438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44644">
        <property type="protein sequence ID" value="OXR44644"/>
        <property type="gene ID" value="B7C42_03438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009016">
        <property type="term" value="F:succinyldiaminopimelate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="42204" checksum="6436924DEA1ED3C2" modified="2017-10-25" version="1">MSAIPTVARLRPFRATIFAEMTELAGRHDAVNLGQGFPDTDGPAAMLEVARTAIADGLNQYPPGRGMPVLRRAIAADRKRRYGVDYDVDSQVVVTVGATEAIAAAVLGLVETDEEVVLIEPYYDSYAAVVALAGATRRTARLVPDGNGFVLDLDSLRAAITPKTRMLLLNSPHNPTGAILPRADLEAIAELAREHDLIVVSDEVYEHLVYDGNTHLSISTLPGMFERTVVISSAAKTFSVTGWKIGWACGPAPLIDGLLAAKQFMSFVGGGPFQPAVAYALENEQQWVADLRDSLSDKRIRLSEALADAGFLVKRSDATYFVCADISPLSSADALVFCRELPQRLGVVAVPIEVFADDRDSWNRLVRFAFCKRDDTLDEAVRRLHAAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6V1</accession>
    <name>A0A231H6V1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyl-CoA dehydrogenase fadE25</fullName>
            <ecNumber evidence="6">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44456">
        <property type="protein sequence ID" value="OXR44456"/>
        <property type="gene ID" value="B7C42_03245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="212"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="359" mass="37855" checksum="05E255958E6A467E" modified="2017-10-25" version="1">MDFTRDESQDAVAEVVVSLLEHDSARDLALWPALVDSGLLALPLPEEHGGDGMGLLEVSTLLTELATDAVAVPALSTLGFGVLPLVGRAGDVLAAKVFPAVAKGAILTAALHEPGAPFVADPQTKAVADGDSVRITGRKVAVPYAEQAQWILVPTDRGIAVVDGDANGITRTESPSSTGAPEFSVSFEDTVIPAAQLLDIPLADLHRIALATLGAVADGLLKGVLALTSEHLRTRQQFGRPLAEFQAVAQEIADVYVVSRTLQVAATSANWSLAQTFGGENYSGDKHLQRVDDDLDVLAFCVASELPAAMQRCHHLHGGIGVDVTHPLHRYYSQAKDIARWLGGASFRLDRLGARCTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H735</accession>
    <name>A0A231H735_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoacrylate hydrolase RutD</fullName>
            <ecNumber evidence="2">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rutD_4</name>
        <name evidence="2" type="ORF">B7C42_03325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44536">
        <property type="protein sequence ID" value="OXR44536"/>
        <property type="gene ID" value="B7C42_03325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="28491" checksum="9CBFDF6D66C41A44" modified="2017-10-25" version="1">MTFATARIQGGTAEVAYEVTGTGPAVVLVHGTAAARDQWAPLTADIADRYTVVALDCSGSGDTVDHGGRLTVADLAAEVRAVADHAGLARFHLVGHSLGAVVAAHVAATVPDRVRSLLMHAGWVRTDARMDAEFRYWIEVLRADAAYGTSLFAHMLPLMAFGPRYWERTSADENAALIEQLAKVIARGAARQTEVDRTVDLTDLLGSIAAPTLILASAHDRVVPAAQQQQLLAAIPDARYAEIDAGHGAPGEDPAGFHAKIISFLDAQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7R7</accession>
    <name>A0A231H7R7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG2_2</name>
        <name evidence="1" type="ORF">B7C42_02877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44921">
        <property type="protein sequence ID" value="OXR44921"/>
        <property type="gene ID" value="B7C42_02877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="26269" checksum="9106F7531ABA0135" modified="2017-10-25" version="1">MRLEGKVAIVTGGAGGIGRGIVRAFAKEGAEILFVDINDEAGHELEQELAGAAAYLHADITRAESAELIVTAAVERFGSVHVLVDNAHVSKQAPLLETTQEMFDLSFGTGFYPTFRLMRACYPHLKRNRGSVINFASGAGLEGQVRQGSYAAAKEAIRAISRVAANEWAADDINVNVISPLALTEGVAAYIEANPGVEEALLARTPLHRFGDPETDIGRVAVFLASADAKYMTGQTLMVDGGSIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7U0</accession>
    <name>A0A231H7U0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase CzcO</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">czcO_1</name>
        <name evidence="6" type="ORF">B7C42_02814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44860">
        <property type="protein sequence ID" value="OXR44860"/>
        <property type="gene ID" value="B7C42_02814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="608" mass="68018" checksum="6107BCED1BB00270" modified="2017-10-25" version="1">MTSTLEPVAERSDGAGPQQRVETWLRDFESALAARDIEAAAGMFALDSFWRDLVAFTWNIKTVEGREGVADMLRARLADTDPRGFHTTEPATEDDGVITAWIGFETAVGRAVGHLRLTDEGAWTLLTSLRELKGLEENKGPRRPKGAEHGATRERVTWSEQRERQERELGYTTQPYVLVIGGGQGGIALGARLRQLGVPALVVDKHDRPGDQWRKRYKSLCLHDPVWYDHLPYLPFPDNWPVFTPKDKIGDWLEMYTRVMEVPYWSKTTCTSAAYDDTTGEWTVRVERDGEQVVLRPRHLVLATGMSGKPNIPNFPGMQRFRGEQQHSSQHPGPDAYAGKRVVVIGSNNSAHDICGALWEVGAQVTMVQRSSTHIVRSESLMELGLGDLYSERALANGITTDKADLIFASLPYRIMHQFQIPIYDAIRERDAEFYDRLARAGFELDWGEDGSGLFLKYLRRGSGYYIDVGASELIANGDIALAHGRIRELTEDAVVLDDGTELPADLVVYATGYGSMNGWAADLIGQEVADKVGKCWGYGSGTTKDPGPFEGELRNMWKPTQQDGLWFHGGNLHQSRHYSLYLALQLKARYEQIPTPVYGLQEVHHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7W2</accession>
    <name>A0A231H7W2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45024">
        <property type="protein sequence ID" value="OXR45024"/>
        <property type="gene ID" value="B7C42_02981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="24836" checksum="6BFF192FAE27E861" modified="2017-10-25" version="1">MPHLAVFGAGPALGLSAALRFGRAGYSVTMIARNPETLERLRARLAAEEIEVDVLLADLSDDARVDRVLAELQVAHGLPDVVVYSPGDVSRLPVDALSLDADILRSWLPINLTTPVRIMHALLPAMAARGSGAVLIAQGGSVREPQAALASSSVPQSALLNYLHSIDQQVRPSGVRVGALLITRLIENSAAQELFDSGRFATVEPGDIQRVHPDALAEDLFAMATTDVEVERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H829</accession>
    <name>A0A231H829_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ampH</name>
        <name evidence="2" type="ORF">B7C42_02863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44907">
        <property type="protein sequence ID" value="OXR44907"/>
        <property type="gene ID" value="B7C42_02863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="29602" checksum="B09476DC466C5E82" modified="2017-10-25" version="1">MRALEQIRDWPVRHAAAGVVDTHGVVGTEGDLDRVFALASVTKPLAAYAVLVAVEEGAIELDQPAGPPGSTVRHLLAHTAGLAFDTTVIMAEPGQRRIYSSAGFEVLAEFLTRETGIEFPEYLRQAVFEPLGMKSSVLAGSAGHAARSTVNDLLRFAGELLNPILISGDMLTAATSVQFPGVGGVLPGYGSQRPNDWGLGFEIRDHKTPHWTGGANSPRSYGHFGQSGTFLWVDPEIGVACVALSDENFGDWARAVWPTLSDAVIADIQRIRDTAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H830</accession>
    <name>A0A231H830_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoin dehydrogenase operon transcriptional activator AcoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acoR_3</name>
        <name evidence="4" type="ORF">B7C42_02952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44995">
        <property type="protein sequence ID" value="OXR44995"/>
        <property type="gene ID" value="B7C42_02952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="453" mass="47986" checksum="3CB3A540666348F3" modified="2017-10-25" version="1">MCGPAPGTAGTHGADRAATGEMRMRSGQDSALLRRRAALERQWARWVPSPHDLPAVPAVCSLESGPTASDATDADAVEGDTAQPRADVAQSWVRSRAFVDPATDCAPAVAGDVASTWADSPLRGPIAELSDQLHSITHDAGFVAAVTDEAGTILWSDGGQVMRRRAERVGFTPGGRWDENHMGTNALSLALRTGRPSSVFSAEHLVEALHGWVCYCAPIRAADGRQLGVLDLSTTWDRSHPLAMSTVLSLTAAVEAKLQGGVTNTAAGVRLECLGAAALTRGGRPLRLRRRLLEILTLLALEPDGYTPERLQLAVYGDRPTGSSTLKADVSHLRRATGGDISNRVYRLTTPVSCDATDMLAALAAGDTATAVRLYRGPLLPGSQTPGIVEWREHLEVGIRTAVLSAGEAEYALDYGAKAPGDIEIHEHALRLLPARDARRAVAAARLHSALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H842</accession>
    <name>A0A231H842_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44896">
        <property type="protein sequence ID" value="OXR44896"/>
        <property type="gene ID" value="B7C42_02851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="89" mass="10112" checksum="231702F650E2A5BF" modified="2017-10-25" version="1">MATVQVRDVPDDVAEVIAEKARAEHKSVSAYLRDLMAADVRRELQRRAIATWDEKLRQTQQRIGITGRATTSGAEVVREVRDDYDRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H856</accession>
    <name>A0A231H856_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_02982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45025">
        <property type="protein sequence ID" value="OXR45025"/>
        <property type="gene ID" value="B7C42_02982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="24226" checksum="BF15E2E61DD1BBD0" modified="2017-10-25" version="1">MAEKVARTRDTTVGARPRRRDARDNRDKIAAAARRRFTAEGLDASLNQIARDAGVSIGTLYNHFPTREALIDDALLDLVVASGRSAEEALRADDPWTGLVDHLTKLAQWQANDRGFTDICVYALPADSPIEVAKHQGHTLFRQLVTRAQEAGQLRSDITETDLGLLLWSVVRATDGVRDVAPEAWRRHLTVLLDGLRAEAAHPLPGSALDPQQVRAAMTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8D4</accession>
    <name>A0A231H8D4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780062.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45131">
        <property type="protein sequence ID" value="OXR45131"/>
        <property type="gene ID" value="B7C42_03088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="25924" checksum="E277E8C3DAA0F415" modified="2017-10-25" version="1">MKLGSPPSKGSENGTSPLERAYTDAVDRVDEGDDIRSRILDAAVEQFGALGVRRSTMDDVARRANVSRITVYRRFATKDALVEQVIVREYRRYFDQFLVDIRHARTAADRVVLGFVSSLKVIRKNPIIGGLLAAEPDMLVGSMIGDQGHTVAMVRRFVADQLRREQRAGHVAQEVDVDLVAELMVRISASYLAVPSQVIDLDDDDQVAALARHYLVPMLEPPLDPDADAPATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8G2</accession>
    <name>A0A231H8G2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45161">
        <property type="protein sequence ID" value="OXR45161"/>
        <property type="gene ID" value="B7C42_03119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11639" checksum="E8AD84414187EE7C" modified="2017-10-25" version="1">MTYRYPLFAFIDHGDIGTGEPAAVMLRPGNAGSNTAADHMRVLHESLAQLPWASTWRIGRRVLVRTDSGGEPGSVMPIGSAPASSLSVASAPPMSTDCAPFTACGHCVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8H8</accession>
    <name>A0A231H8H8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid-associated protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybaB_2</name>
        <name evidence="2" type="ORF">B7C42_02448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45323">
        <property type="protein sequence ID" value="OXR45323"/>
        <property type="gene ID" value="B7C42_02448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18228" checksum="538C88902760B1A6" modified="2017-10-25" version="1">MDSSGYDQLRARTDALQVQVDSMLESYEHQLRDIATARDTLAAATAEGWSSDNLIRVTSNSAGIPIQVWVDPAAFKRTTPEKLGDAITEAAQAAARAAKSEVGAAMAPILADEKRFHITNPLGEDLNLERVVGGILPPPPQPVSEPEPVPEPPRVADDDEDNGPHWKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8M8</accession>
    <name>A0A231H8M8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45170">
        <property type="protein sequence ID" value="OXR45170"/>
        <property type="gene ID" value="B7C42_03128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="227" mass="23597" checksum="714CD297AFF8304E" modified="2017-10-25" version="1">MPVWPPGGWLRMPPTGATAGFGHSARPVACPTCSRCRSGKPWLISTADAASTPSLPGRPHTCGTGSRPGWASAVNVNTTGPGPPSPTSVTSPPDTHEPCWPADPSTIPPISPTTCAFTQLRSTGNRSWQSPAPGGRSRNASKPPRTNAASTTTKSANGIPGTGTSPWPCSPMPSSPSPPPPTQKPRGLGRLTVADVRRLLAIVLHPARTLAHALAACHWRRRHQAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8N2</accession>
    <name>A0A231H8N2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45208">
        <property type="protein sequence ID" value="OXR45208"/>
        <property type="gene ID" value="B7C42_02333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646870" evidence="3">
        <location>
            <begin position="28"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="33125" checksum="3867C9B19D65270E" modified="2017-10-25" version="1">MGPTLTRIAAAAVAVGVSGLVSPIAHAEPEPLDGLFALAPGVCADGAVTGSFFRMILPTGDAGGPYLQNSDSRCSDQTVTPLSAGTDGGLIGGSYQPHPAAAFDGAGNARSGRVTTPVRFYGVDFATATNPTDPQTGSGAAVPQIVADGGQLSGDLSSLGVTWNNQVFNQGAPKPGGGLPGKTGPVHGTIDDAGNFVLEWTSQIVGGPFNNFTGLWHLAGQYRGGRVQAAAPAPAPAGPAAAPPAAPGAEAAAPAAPGAAAPAPGAAAPAPAPAAAPAGPNVANVNTDPALATRTIDIPRQHRAPVWVIPALLLLALIAAAVFIKAEAIARWRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H957</accession>
    <name>A0A231H957_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bkdA</name>
        <name evidence="5" type="ORF">B7C42_02352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45227">
        <property type="protein sequence ID" value="OXR45227"/>
        <property type="gene ID" value="B7C42_02352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="57"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="41332" checksum="9B0C2F05FFA845C6" modified="2017-10-25" version="1">MHHTTTHNTTTRYDTGTNPYPVQLVQPDGRRVLDREHAALIADIGPAELRELYEDLVVTRRIDVEATALQRQGQLGLWAPLLGQEASQIGSARALHDDDYVFCSYREAGVAYCRGVDPALITRLWRGVAHSCWDPDEINMTNPAIVVGSQGLHATGYAYAAHLEGAEIAVLTYFGDGASSQGDIAEALGFAASWSAPVVFFCQNNHWAISEPVQLQSQTPIVRRAYGYGIPGVQVDGNDVLAVLAVTRQAVARARAGGGPSFIEAITYRMGPHTTADDPTRYRSAAELELWQRRDPIDRMRRLLEREGLWDSDFERQVTARADAVGAAVRTATIDMPDPDPMQLFDHVYTTAHPLIAAERDEYAGYLAGFEEGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9D6</accession>
    <name>A0A231H9D6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">drrA_5</name>
        <name evidence="6" type="ORF">B7C42_02689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45564">
        <property type="protein sequence ID" value="OXR45564"/>
        <property type="gene ID" value="B7C42_02689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="84"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="40878" checksum="C3016154C865BA7A" modified="2017-10-25" version="1">MPSLDNAESHTPREDSGATDAAASRAGTDAAASRAGTDAAASRAGTDAAASRAGTDAAVSRAGTDAAVSRADTAVTASGTDPAVVVDDVRKSFGEVQALQGISFTAARASVLGILGPNGAGKTTTVKILSTLLRPDSGSASVAGHDVVADAAGVRRSIMMTGQYAALDENLSGRENLELFGRLMGLPKKDARRRADTLLEEFDLVGAGKRAVRHYSGGMRRRVDIACGLVVRPEVVFLDEPTTGLDPRSRQGVWDLVNALKEQGITVLLTTQYLEEADVLSDNIIVIDKGTVIAEGTADELKEKTGGSYCEVVPLDPTQLRKAVTALGELVPEALRHEFAGDRISIPAPDGASTLAEAVRRLDAAGLELADIALRRPSLDDVFLSITGHSGGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9G5</accession>
    <name>A0A231H9G5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45489">
        <property type="protein sequence ID" value="OXR45489"/>
        <property type="gene ID" value="B7C42_02614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28887" checksum="7D3D4A3A8DC2050D" modified="2017-10-25" version="1">MAGSVMAEDNDRDLAAAIGDLAARSGLGRHQQTYLPRSPRTGGKIVLIVLASAGVIAAVVSFAVGQPVLGILAAIFPIVLVPALIRAFRYTRSYEGARLDLYERGLVAALLGRLWAVRYDSTTVYQNIVRHMRNGHHIGTTYAYTLTDLAGTNFVVGDGISDPQQWGPAIQRAVTDAQLPQALAALQAGHRLVFGELWMTWYEVGSPRKSAPWTQVNQVSISDGRLSVDVAGRWFALTSAMVSDIPNFLIFEALATHLSRVHGGSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9H6</accession>
    <name>A0A231H9H6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase NlhH</fullName>
            <ecNumber evidence="2">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nlhH_2</name>
        <name evidence="2" type="ORF">B7C42_01896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45604">
        <property type="protein sequence ID" value="OXR45604"/>
        <property type="gene ID" value="B7C42_01896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="94"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="35042" checksum="8274AD9ED3740705" modified="2017-10-25" version="1">MNTEYGPCPPIDAEVARALRQIEQLVPRVAPDTLAQVRSIVADGIPGAPTPDFTAGGAVVVEESVVPGPAGAPDVPVVVLRPAEGSGPWPAIYNIHGGGMVAGTPRTALDQLVAYVHEIGVVVVSVDYRLAPEHPDPAPLEDCYAGLCWLADRSADLQVDPARIMIAGISAGGGLAAGTALLARDRGGPALTHQILSAPMLDDRLRTPSAQMLLREGVWDRAENEYGWTSLLGDRRGGPDVSPYSAPARAEDLAGLPRTFIDVGSVETFRDEVIDYATRLSRAGVSVDLHVWGGGVHGFDLSVPGAAISRAALSARDAFIRTALGSRPHNAVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9P6</accession>
    <name>A0A231H9P6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Processive diacylglycerol beta-glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.315</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ugtP</name>
        <name evidence="5" type="ORF">B7C42_01966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.315" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45674">
        <property type="protein sequence ID" value="OXR45674"/>
        <property type="gene ID" value="B7C42_01966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="4">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="371" mass="39525" checksum="349A378E6A670917" modified="2017-10-25" version="1">MAPPSALLLSGSLGMGHDVMAEACAVSLRRRGWTTDTVDSMRLMGHRRGGLGEAVFRGMLAVPGLYDAFHFGQLRSGGRLARFIDAASCRYLVPALDERLRDRPVELLVSVFATGAAAASRIKERHPDVVNAVFCTDTCPHRLWVHDNTDLYLVTSDPAARYIRRFDPDAEITVVPAPVRSQFYRAPTQAAAREALGVPPDAECVLLISGAWGVGPLVEAADLIARAGVHVLAVAGRNAGLESRLRSLAATTDRVVPFGFTDEIPTLMAAADLVVTSSGDTCAEARVIGRDLLLLDVVPGHGRENLHQELVRGGAAVTSAQPEAIRRSVSACLRRVEPSSARSAGEPTAWEEAFGTMLERVGPAGWAAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9X6</accession>
    <name>A0A231H9X6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45641">
        <property type="protein sequence ID" value="OXR45641"/>
        <property type="gene ID" value="B7C42_01933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12690" checksum="2E8971F065B2F978" modified="2017-10-25" version="1">MAPETPRPGRPVRGSTTGRPIMALFDLLGRRWILRVIWELDQAPGPLTFRELRTVCGDISSSVLTRRLAELTEARLIEREEGYRLTRAGRTLVERLAPLTHWAAEWRNDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAG6</accession>
    <name>A0A231HAG6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Resuscitation-promoting factor RpfD</fullName>
            <ecNumber evidence="4">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpfD</name>
        <name evidence="4" type="ORF">B7C42_02246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514506.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45953">
        <property type="protein sequence ID" value="OXR45953"/>
        <property type="gene ID" value="B7C42_02246"/>
    </dbReference>
    <dbReference type="GeneID" id="66720049"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011291961" evidence="2">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="3">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11201" checksum="5AB00C8FF91A6FF5" modified="2017-10-25" version="1">MSRNRKFSTRALGFAAVAGAIVAVPFGLTATASADGGHDWDAVAQCEASGNWGADTGNGFYGGLQFTQSTWNANGGSGNPANASRAEQIRVAENVLASQGPGAWPVCGANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAL1</accession>
    <name>A0A231HAL1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator YfmP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfmP</name>
        <name evidence="2" type="ORF">B7C42_02183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778165.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45891">
        <property type="protein sequence ID" value="OXR45891"/>
        <property type="gene ID" value="B7C42_02183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="27967" checksum="3C931D0C87743656" modified="2017-10-25" version="1">MAEYRIDELARAAGTTSRNVRAYQERGLLPPPVRRIGRALIYDDSHLERLKIIDVLLQRGFTTAHIADFITGWETGKDLTEILGLQHAVTAAWGQQDETLQVPRELIDTFLGEEAADPAILERLAELGLARIGTETVEFTDPQLLENFAELHGYGFRLGRLADLQAAVSGRLDEIAHDMMAAAKEHIVDAHGPGWLPDTDDEIAETAKMLTHLRGLAVTAVNNTLARSLDRVLREELGDYLAEAVDRRAKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAW4</accession>
    <name>A0A231HAW4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778153.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45886">
        <property type="protein sequence ID" value="OXR45886"/>
        <property type="gene ID" value="B7C42_02178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8090" checksum="F2FA3FD28D3CC420" modified="2017-10-25" version="1">MSINGLSAAQQRAALRRLVVAFGELNTIVELAAAEASPDLREHAEIARDMLGALVTEVAQPSRDRRCYLPLTNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB36</accession>
    <name>A0A231HB36_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_5</name>
        <name evidence="3" type="ORF">B7C42_02230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45937">
        <property type="protein sequence ID" value="OXR45937"/>
        <property type="gene ID" value="B7C42_02230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="441"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="539" mass="57646" checksum="F9E613E94DD9EA39" modified="2017-10-25" version="1">MPETETSTIDPATLLRLPTHNGHALLAGLRRHRREPVMTLGDTVLTGADVIDAISRYIAAFAAHEVGLGTPSALLALNRPEVLFILGAGQIAGHRRTALHPMGGLDDHVHVLTDAGITNLVIDPQPAFVRRARELADRVPELKRILVLGPVPEELADIGVDLISAAAEFTPEPIEAVDIPPDFVVSISYTGGTTGKPKGVIGTAGTMATMTQIQLSEWEWPQRPRFLICTPLSHAGAAFFLPVVLQGGQCVVLPRFDAGEVLRAIEEHRISATMLVPSMLYALLDHPDIDSRDLSSLETIYYGASSIDPKRLTQAIARFGPIFAQYYGQSEAPMVISYLGKDEHDEARLTSCGRPSAALRTGLIGTDGQRVAPGEVGEICVSGPLLAGGYLNLPEVTAETFRDGWLHTGDLAREDPDGFWHIVGRSKDMIVTGGFNVFPREVEDVIAADARVQGVAVVGVTDPRWGEAVTAAVVFDPATAADPDAVAAAIDDIQQDVKRRKGSVQAPKHVIVVDALPLTGLGKVDKKAVQVLVTAELDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB83</accession>
    <name>A0A231HB83_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46111">
        <property type="protein sequence ID" value="OXR46111"/>
        <property type="gene ID" value="B7C42_01075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="9026" checksum="2B4DFC436E96655A" modified="2017-10-25" version="1">MFSGLAALLVVAVVLLAAYRYATGSGRRVVALFERYRPHAPMADWSLREGECRDPARDLAALRGRQTCVARDRSATRPPVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB85</accession>
    <name>A0A231HB85_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">hmp_2</name>
        <name evidence="17" type="ORF">B7C42_01105</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46140">
        <property type="protein sequence ID" value="OXR46140"/>
        <property type="gene ID" value="B7C42_01105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="15">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="143"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR46140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="42906" checksum="873E93EF499F0C0D" modified="2017-10-25" version="1">MDSRTVALIRTTFKAVAAEDGGPEQLARSFYALLFTEYPQLRDFFPAALEVQRDRLVKAIGYAVDRLEEPEQLLPFLAQLGRDHRKYGVMAEHYAAVGNSLKSALRAHAGTELWTDEVEQAWDVGLGLISETMIGAAELETTPPVWTGTVVEYREVLCNLVVVRLRLDQPMSYAAGQYVSVQIPARPRMWRYLSPAIPANPQGEIEFHIRSVSGGWVSPAMVGHTAIGDQWLLGAPLGGLGVPRNTRRKMLMVGCGTGIAPLRAQLLAMSQRRSNPKVHLFVGGHHPCDLYDLPTLSELAVANKWLTVVPVTESDDNPWWYYHPERIEPDLPGIAPRETGQIGAVVARGGDWSDCDVQIVGSPSTVQTTKFRLMAAGTPTENIRHDPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBF1</accession>
    <name>A0A231HBF1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781343.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46047">
        <property type="protein sequence ID" value="OXR46047"/>
        <property type="gene ID" value="B7C42_01010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="42403" checksum="3D45EE8EF6B58FEB" modified="2017-10-25" version="1">MGGAGSRTVPWNGSPRPTLGVEWEIALVDKQTRNLSNTAAAVFDQVGDLRAPNGPPHVTKELLKNTVELVSGVHDTVGEVVDEMHATMDIVRAAADRVGVDLFCAGTHPFAQWSTQQLTRSEHYDELISRTQWWGRQMLIWGVHVHVGVSHPEKVFPILNTLLLSYPHLLALSASSPMWAGIDTGYASNRALMFQQLPTAGLPFQFENWSQFESFVHDQMKTGVFEQLGGMHWDIRPAPKWGTIEVRVCDGIPSRFELSALVALIHCLIVDLDRRVEAGETMPTLPPWHVQENKWRAARYGLDAIIITDSDSNERLVTDDLMDLLDRLQPTAKLLQCENELARVPDIVERGASYQRQRRVAAAAQGDLVAVVDALVKELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC02</accession>
    <name>A0A231HC02_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="2">5.3.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.29" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46352">
        <property type="protein sequence ID" value="OXR46352"/>
        <property type="gene ID" value="B7C42_01318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043917">
        <property type="term" value="F:ribose 1,5-bisphosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="520" mass="56707" checksum="078A67BA6546DADA" modified="2017-10-25" version="1">MRDSYDVVIVGGGHNGLVAAAYLARAGLSVLVLERQDHTGGAAVSERVFAGIDARLSRYSYLVSLLPDRIVRDLELPFRTRERRISSYTPVGDTGLLVDTADAGRTRESFRRVTGSDADFEAWQQFYATTTRAAQRIFPTLLRPLPTRAELQRTLDDPDIWEMLFERPLGETVEARFRDDTVRGVVFTDALIGTFTHAHDPELRQNRCFLYHVIGNGTGEWNVPVGGMGALTDALADAARRAGAHLRTSCTVTGIDTDGDTAQVRFDTPDESGLADARHVLVNAAPATLARLLGEPVDAMPEGSQFKVNMLLRRLPRLRTDIDPREAFSGTFHIAEGYDRLEQAYREAAAGRFPSAPPSEIYCHTLTDPSILSPDAAERGMHTLTLFGLHTPATLFEHGSRDELLAATLRELNSVLAEPISDYLAADANGDPCIEARTPLELESELRLPRGHIFHGDLDFPYRTDDDASPAARWGVRTGHRNIFRCGAGAVRGGGVSGIGGHNAAMAVLEITGRATPTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC98</accession>
    <name>A0A231HC98_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator MhqR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhqR_1</name>
        <name evidence="2" type="ORF">B7C42_01534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46563">
        <property type="protein sequence ID" value="OXR46563"/>
        <property type="gene ID" value="B7C42_01534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="18920" checksum="8412328469357032" modified="2017-10-25" version="1">MSDAVDRIVADWGRVRPDLDVWPTHVIGRLKRMGRRLEREMKEFFARYGLEYWEFDVLSTLRRSGGPDGLTAGDLIKATMVTSGAITNRIDRMAAKDLVRRVPDAKDRRTIRVQLTDHGREVIDEVMPLHVDNEVSLLSGMSRTELDQLADLLRRLSESLDDTSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCB1</accession>
    <name>A0A231HCB1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator CdhR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdhR_3</name>
        <name evidence="2" type="ORF">B7C42_01455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775049.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46485">
        <property type="protein sequence ID" value="OXR46485"/>
        <property type="gene ID" value="B7C42_01455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="222"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="35820" checksum="33B62839095B0065" modified="2017-10-25" version="1">MALELAQLPRRRIGILVFDGVKMLDFTGPAEVFVEANQACPGYEVVLVSADGGSVETSIGARIECAVAAADAGVFDTVVIPGSELPPSRFVTPELLAAARRLSWNTRRLASVCSGAFVLAELGLFDGRRATTHWKFAAHLARRYPAIDVAADDIYVRDGNLYSSAGVTAGIDLALAMVEEDFGPDIARRIAQLMVVYMHRAGGQSQFSASLSGPAPRSPLVRKAVDLICAEPAFPHTVRTLAAHANVSPRHLSRLFRAELERSPAEYVAFIRFGVARDMLHAGCGVTEAAMAAGYGSSEAMRRAFIARLGISPSKYQRRFRSTGSGETPLVAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCD7</accession>
    <name>A0A231HCD7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46327">
        <property type="protein sequence ID" value="OXR46327"/>
        <property type="gene ID" value="B7C42_01293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035169">
        <property type="entry name" value="DUF5318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17249">
        <property type="entry name" value="DUF5318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="17219" checksum="AE237E59CEB88781" modified="2017-10-25" version="1">MWLLSVACRAPADASTLGSVRIQRQVVDYALRRRSLLADVYAGRVDVAEVCDANPYLLRAAKFHGRGSDVTCPICRKEQLTLVSWVYGDGLGPIAGSARTPEELVRLAETREEFSVHVVEVCRTCSWNHLVQSYVLGHTPAPRRRRGGGARRTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCK4</accession>
    <name>A0A231HCK4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase enhancer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lytB</name>
        <name evidence="4" type="ORF">B7C42_01533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46562">
        <property type="protein sequence ID" value="OXR46562"/>
        <property type="gene ID" value="B7C42_01533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="3">
        <location>
            <begin position="233"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="525" mass="53153" checksum="41A2587159293182" modified="2017-10-25" version="1">MTRTEAAPTGAAPPPDRSDSAPVDGVVAGFRSRLRRRHGELLRRRHMRRAALLGLLVVPVTGGIVVAFAVPMFGSGTRNAAYQAAAGPGHGRGMSQVGAFDQATAGATADGILAHYYPGAQLGTTEPTTVRVRLTVYDNETLDVYSDSGLTVAGRRVVAGQAAHLTPTPDGGANVVVTIGCDGDVLWQGSTDDPWAYPADAGPDRPEAEHLKVCDGSSFRGALGVTQDGGHPATVNQLDVEDYLLGVVPAEMEADWADKGGAEALRAQAIAARSYALAEHRYPYAQTCDTTDCQMYPGTDKEDPRTVDAVHATAGQVLLRDGHILRTEYSAAPGGGQPIDIATLEVGPTPAELEAAPAVPEAPAAPAPAVPEQAVRGNSAIDVKYAESGGAAGPLGDPMGPESLLPGKVGTFRLYQGGVIIATPTLGAQIVDYARLLQIAPQVSQSGGENAGAQAAAPGGTHSPGTAATPTPSPAPTGQQARTGPADPAGTPAAATGSPADPPAAGIAAPDHTATAPAAAASRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD49</accession>
    <name>A0A231HD49_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine monooxygenase RutA</fullName>
            <ecNumber evidence="2">1.14.99.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rutA_2</name>
        <name evidence="2" type="ORF">B7C42_01828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.46" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775607.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46850">
        <property type="protein sequence ID" value="OXR46850"/>
        <property type="gene ID" value="B7C42_01828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="31483" checksum="8C43D6C6517E120F" modified="2017-10-25" version="1">MRFGIVLFTSDRGIRPAVAAKAAEERGFESFFVPEHTHIPIKREAAHPLTGDESLPDDRYMRTLDPWVALATAAAVTERIELSTAVALPTEHDPITLAKTIATLDHLSGGRVSVGAGFGWNTDELADHGVPGNKRRTVLREYLEAMRALWTEEEASYDGDFVKFGPSWAWPKPVQAEVPVLIGTAGTEQGFRWIARSADGWITTPYETHTLLERLQLLTKVWQEAGREDTPRVVALDGKPDTQRLTEWSAAGVTDVLYGLPDKSEAEVLAYLDRLAGKLAPLRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD90</accession>
    <name>A0A231HD90_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional repressor YvoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yvoA_1</name>
        <name evidence="3" type="ORF">B7C42_01760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46782">
        <property type="protein sequence ID" value="OXR46782"/>
        <property type="gene ID" value="B7C42_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="31052" checksum="4D59706B1E9459FA" modified="2017-10-25" version="1">MTADPVPLRQQRGAAADHPAAGAETTAPGAGARTIRKADRARQVADVLRQQIHTGQCPDPLPTESELAAEFAVSRNAVREALALLRDEGLIGRVPRVGTYVAQRKYDHGLDSLRGLKETLRGHGEVRNEVRAALRLTPPPAVAGRLGLEPGESAVYLERLRYLGDLPLSLDHTYLAPDIGEQVLDCDLRSEDIFGLIEQISGQSLGSADLAVEAITADIHSAATLQAPEGSALLLLERLTYLADGRPVDLEYIRMRGDRITLRDSLIRTTESNDWRLSRHGVGQSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDH6</accession>
    <name>A0A231HDH6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46815">
        <property type="protein sequence ID" value="OXR46815"/>
        <property type="gene ID" value="B7C42_01793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="401" mass="43518" checksum="2F45AF82161B9903" modified="2017-10-25" version="1">MTGVRRTRIQAVTEDASVTQLELFFDLVLVFAFTQVTDLAAHDVTALNMLRAALVLAVMWWVWIAYAWLGNVVKADEGVARVAMFAAMGAGLIVAEVIPEAFHDMPGGWYGPLVFAIGYLVIRLVHLGMFWLASTEDRQLRGQVGRWAGGSITIGTALLIVAAVEHGTVQIVLWIAAIAGDMVWTFFAGNDWRVNSASHFAERHGLIVIVALGESIVSIGVGVAGLPISWPITVGSLLALTVSGLLWWAYFDVAATVVERAMTEASGPRRIRIARNCYTFLHFPMVAGIVAMSLGLKKTLNYLGGAAGHTLHDRLHGIPLFALYGGVVLYLLALVWFRHYATRVVLWPRLATAAVLIALVPLAGQLPAMAALALLCAVLTVLIVWETVRYAQPRDAVRHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE75</accession>
    <name>A0A231HE75_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD-linked oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47159">
        <property type="protein sequence ID" value="OXR47159"/>
        <property type="gene ID" value="B7C42_00281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="93"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="525" mass="54167" checksum="563588536BFDBC08" modified="2017-10-25" version="1">MVWDAWGIASAHAPLSDRIRTLVAQVFGVSGEPVARRDEGDVPLRESGLTAAHRAGLSAVVGADQVSADPRDRLLHAGGKSTPDLLRRRAEAPQDAPDAVVFPADHDQVLAVLTYCTEQSIAVVPFGGGTSVVGGVDPARGRFDTVIALDLRRLDGLSDVDPVSGTATLGAGLTGPQAEKLLAAHGLSLGHFPQSFEYASIGGFAATRSSGQASAGYGRFDDMIMRLKVATPTGTVDLGRAPASAAGPDLRELFAGSEGTLGVITEVTLRVHPIPETTAYQAWSFPDFATGAAALRTVVQNGAAPTVLRLSDEAETGLNLARSGDIGGAPVSGCLAVTTFEGTEAHVAARSAEASALLAAAGGTALGEQPAREWEHGRFAAPYLRDALLDIGVLCETLETATSWSNVERLKAAVTTALTESLGAQGTPALVMCHISHTYPTGASLYFTVVAKQADDAAAQWARAKRAVGDAIAGHGGTITHHHAVGADHRPWMTAEIGDLGARILRAVKDAVDPAGILNPGKLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HED7</accession>
    <name>A0A231HED7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47310">
        <property type="protein sequence ID" value="OXR47310"/>
        <property type="gene ID" value="B7C42_00432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="3">
        <location>
            <begin position="87"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="27363" checksum="6AE3B30E3DC5895A" modified="2017-10-25" version="1">MPGSGEDPALRNRGVTEHWHTRGMPSALTHPAPTRPPAAPRRPRGSAVVRWVRRVIAGTVLIGVVLVGGTAFRVWQVARIDDYSRADAIVVLGAAQYDGTPSSVFEARLGQAYHLYTKGVAPLVITVGGKQVGDNYTEAASGKNYLKNRGVPADRVLAVETGSDTLQSIEAVASAMRARDLSSAVLVSDPWHSLRTRTMARDAGLDAWTAPTRTGPAVYTRESQFHGIARETGALLWYQLTHFSADFKYTAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEH1</accession>
    <name>A0A231HEH1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein Stp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">stp_2</name>
        <name evidence="8" type="ORF">B7C42_00354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777125.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47232">
        <property type="protein sequence ID" value="OXR47232"/>
        <property type="gene ID" value="B7C42_00354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="531" mass="53747" checksum="5207C0A1A831449B" modified="2017-10-25" version="1">MVATIRLSSGSGRWVLLATVLGSGMAMLDATVVNVALPRIGAEFGASMAGLQWTVNAYTLTLAGLILLGGSLGDRFGRRRIFVVGVVWFALASALCGAAQGIPMLIAARALQGVGGALLTPGSLAIIQASFAKSDRARAVGAWSGLGGVAGAIGPFLGGWLVGAAGWRWVFLLNIPLAAVVVLVAVRHVPETYGSGAADGSASARPAPESGRPAHEGFDVLGAFLAALCLAGITYALTMAPEHGSSRTAVVATAVIGVLAGVAFVVVERRRSARYEAPGHHGGPPPMLPVEIFASRQFSAINAVTFVMYGAMGVVFFLLVLTLQVVAGFSPMAAGTAMLPSTVLMLLFSARSGDLAQRIGPRIPITAGVLLAAAGMLLMMRIGPDASYVTDVLPAALVFGLGLTLAVAPLTATVLATADERHAGVASGVNNAVARAAGLLAVAAIPPLTGLTGAAYTDPAAFEQGFREAMLICAIVMAAAAALTVVTVRDDALRDASPEATPQCKINCAVAGPPLEPRHAEATSGPAGDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEI7</accession>
    <name>A0A231HEI7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome b6-f complex iron-sulfur subunit</fullName>
            <ecNumber evidence="5">1.10.9.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">petC_1</name>
        <name evidence="5" type="ORF">B7C42_00494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.9.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47371">
        <property type="protein sequence ID" value="OXR47371"/>
        <property type="gene ID" value="B7C42_00494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="24422" checksum="6BB178A629CEE909" modified="2017-10-25" version="1">MSSKDVERYVDDILAGRSPRGFRPDDDDAAQIRAAIALRSARTGAGSPDEEFIARLHHRLAEDLDEPAADPGARTRRPTRRTVLIGTSVAAAAAAGGVIDHTLLSGPGEPKVPAAQQTLVPSHGTWQPVLASTELADGATAPFELGAVNGFLRRRDGIVYALSGICTHQGCRLWLDAAAARLRCPCHSTSFGFEGEVLTHELPRTPAPLPRLQVRESNGSIEVFAPAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF35</accession>
    <name>A0A231HF35_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PhoH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_00409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47287">
        <property type="protein sequence ID" value="OXR47287"/>
        <property type="gene ID" value="B7C42_00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="106"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="37087" checksum="98319AF927F28250" modified="2017-10-25" version="1">MRSSIELAPESVFGFLGSADANLRELEGLLDADIHVRGNSVTLTGKAADVALAERVVEQLVALTAHNRVVTPEAVRHTVSMLTEGSSDSPAEVLSLDIIARRGKTIRPKTLNQKRYVDAIDEHTIVFGIGPAGTGKTYLAVAKAVQALQSKQVTRIILTRPAVEAGERLGFLPGTLNEKIDPYLRPLYDALHDMMDPEAIPKLMASGVIEVAPLAYMRGRSLNDSFIILDEAQNTTPEQMKMFLTRLGFGSKIVVTGDVTQVDLPGGTRSGLRVVSDILTDVDDIHFAELTSSDVVRHRLVSEIVDAYERYESDARPQVARHYPGGNRAQRRAADKAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF68</accession>
    <name>A0A231HF68_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoheptose isomerase</fullName>
            <ecNumber evidence="9">5.3.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sedoheptulose 7-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gmhA</name>
        <name evidence="11" type="ORF">B7C42_00458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042337.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47335">
        <property type="protein sequence ID" value="OXR47335"/>
        <property type="gene ID" value="B7C42_00458"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00041">
        <property type="reaction ID" value="UER00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001061">
        <property type="term" value="P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00067">
        <property type="entry name" value="GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="49"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="206" mass="21894" checksum="A164037709F6E781" modified="2017-10-25" version="1">MTGPRDEYRRHDVAGIGTELEEHFELLGTALRRNVRPSVAHIWDWGERLACVYRDGGRLFACGNGGSAAEAQHLTAELTGRFREERRPLSAVALHADTSSVTAIANDYGFDEMFARQLRAHGRPGDVLVAMSTSGSSGNVVAAAKAAADIGLTSWALTGPAPNSLASLCDDAVAVEAESTATVQEVHLVLVHALCTALDSALRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFC5</accession>
    <name>A0A231HFC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hca operon transcriptional activator HcaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hcaR_1</name>
        <name evidence="3" type="ORF">B7C42_00709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47584">
        <property type="protein sequence ID" value="OXR47584"/>
        <property type="gene ID" value="B7C42_00709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="26220" checksum="CA051A514B1BDE22" modified="2017-10-25" version="1">MTESAPTALRIGYVPGVTVAKWARVWAERFPDVPLDVIAVPQAQQHEALAQGRVDMCFVRLPIEREGLHAIPLYHEVAVAVVPKDHPIGLFDEVSLADLDGERMQDASDLDAVGGTVELVAAVGGAAVMPQSLARLHHRRDLIYRPLTDVDPTQIALSWPIEDAVELAEEFIGVVRGRTARSSRTTGERDRRGRQDSGTRAEGGAAQRARGRGESGAKPAARRGGAAKPGRAGKAGGPRKRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG20</accession>
    <name>A0A231HG20_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_2</name>
        <name evidence="1" type="ORF">B7C42_00949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779662.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47824">
        <property type="protein sequence ID" value="OXR47824"/>
        <property type="gene ID" value="B7C42_00949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="25999" checksum="1D458D732D50D835" modified="2017-10-25" version="1">MYLGLENGVALVTAASRGIGRATAERLAAEGMTVIAAARSAGGEPETVGSGSIVPFAHDLGDAAATAALVDTVVSAYGAVDVVVLNTPGPRIVPALEAAWDDWTAAHDTLLRPVVQLATAAGRVMRDKGAGAIILLSSTWVRQPAAGGVLSAAYRSAASAFVKNLASELAPAGVRVNQIMPGATGTDRMQGIVEMKSDRNGTTVEEEIARVVADIPAGRWAEASEIADAVAFLASARASFITGTSLSVDGGAVRAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSI5</accession>
    <name>A0A231GSI5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000282">
        <property type="protein sequence ID" value="OXR39580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39580">
        <property type="protein sequence ID" value="OXR39580"/>
        <property type="gene ID" value="B7C42_08352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="55" mass="5961" checksum="A8F0F7431481ADAC" modified="2017-10-25" version="1">MEANQNSNSPKDFTDTRLTPVMTVSSTADSIHWSRSIQLPRMAAPATASAPTRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSP9</accession>
    <name>A0A231GSP9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000104">
        <property type="protein sequence ID" value="OXR39646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39646">
        <property type="protein sequence ID" value="OXR39646"/>
        <property type="gene ID" value="B7C42_08284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="54"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="27289" checksum="3479FCE04F50BBD2" modified="2017-10-25" version="1">MVAQLREVDIDALCKIYEFDAEHVAAMKALAVQGNELSWWCEYDDLLPANFDFYVGLEASAHRLTTYEPELVPGLLQTPAYASALFHAGYPNDSADEHARRVQLRMRRQTRITRKHRPAELNVILREAVLRCMVGGPKIMAGQLRHLADLGTRPNVNVQILPFSAGIPMGDAVGPFVVLDFGAPGAERVAEPSVVYVEGFTGDLYLEKPSAVERYHQAYEDLRRSAVDAVASRAMLRQMAKEYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT18</accession>
    <name>A0A231GT18_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formyl-CoA:oxalate CoA-transferase</fullName>
            <ecNumber evidence="1">2.8.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frc</name>
        <name evidence="1" type="ORF">B7C42_08154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.16" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000068">
        <property type="protein sequence ID" value="OXR39769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39769">
        <property type="protein sequence ID" value="OXR39769"/>
        <property type="gene ID" value="B7C42_08154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033608">
        <property type="term" value="F:formyl-CoA transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="9126" checksum="BF07B1D1BF8D5376" modified="2017-10-25" version="1">MNPSNSQHRGVLRTAIHPAFGEYRQIPHPIIYDRKDTAVRSHAPFVGEHTMQVLREAGLSAAEITQLLSDGAAVQGRQKPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT30</accession>
    <name>A0A231GT30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000075">
        <property type="protein sequence ID" value="OXR39738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39738">
        <property type="protein sequence ID" value="OXR39738"/>
        <property type="gene ID" value="B7C42_08188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="125" mass="14502" checksum="EA1D961621D60DA0" modified="2017-10-25" version="1">MHRACLRPGEANASRIWNTYVKPLVDPFVGDSNEHRYCDEDEFHELIWDTWCQAGVDNDVTIEHESKLSEGSSAVRGSRIDFRFYYDDLYRVEVEVKPRAGGRRSRCKNSSCATPRPARSIRCWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT95</accession>
    <name>A0A231GT95_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000058">
        <property type="protein sequence ID" value="OXR39847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39847">
        <property type="protein sequence ID" value="OXR39847"/>
        <property type="gene ID" value="B7C42_08088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="478" mass="52759" checksum="090D072BC816F083" modified="2017-10-25" version="1">MTRVPDQQRYCVRCGSRLNSYNDESLCSPCTVGVRRELHEPPAVPPSFWQTDQMRDALATWHMGRVIFAYRNHPYHRQPLPQERVADWLGITQAQLSRLEKGPAPEHLSKLRRWAQRLAIPPELLWFKLPGAEVATLEDVKRQDFLRAALGVTVTGAAAPLLELLSTVEPTPVPSAVGLTEIEQIRQTAREFSTWDHTYGGGLVREAVGAQLRYAVNLLNARCPEKYRSELQSAVGFLGHTAAFMAFDAYAHADARSMFRLAWTCAEEAGNWHLRGKVLSSIARQAIWCGSADDGLTYIELAMVRSDRLTATERAMLHSARARALAKLHRVEEAVQAVGQADEEFSHASPQDDPPWMSYYDAAQHSGDTGHALFDLALEGQFVSEARSRLQSAVHGHTEAYVRSKAISGIKLASLTMATGDPSEAAQLGSAALLDAGHIRSRRAADDLRELSSLSEPHSTATEVEELRTRIGITVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTB9</accession>
    <name>A0A231GTB9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kshA_8</name>
        <name evidence="9" type="ORF">B7C42_08052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778604.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39877">
        <property type="protein sequence ID" value="OXR39877"/>
        <property type="gene ID" value="B7C42_08052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR39877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="380" mass="43037" checksum="7A1937022A02B76F" modified="2017-10-25" version="1">MTTVHDEVRRIEAEAAPKRFARGWHCLGLSKDFADGRPHSIQAFGTKLVVFRGEDGKLNILDAYCRHMGGDLSDGEIKGNEIACPFHDWRWGGDGRCKQIPYARRVPPLARTRTWTTLEQDGMLFVWNDPEGNPPPAEVTIPRIEGAGSDSWTDWHWYTTVVHTNCREIVDNVVDMAHFFYIHGSLPTYFKNVFEGHIATQYFKSGPRADLPGPEGQPALLGTTSVASYYGPSFMIDDLVYHYENGDYKTVLLNCHYPIDENSFVLQYGIIVEKSEGLPEDEAIATAVALGDWVKIGFEQDVAIWKRKARIDNPLLCEEDGPVYQLRRWYQQFYVDAAEVAPEMVDRFEFELDTTRPLEAWQREVQANLARGAESAGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTE6</accession>
    <name>A0A231GTE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39894">
        <property type="protein sequence ID" value="OXR39894"/>
        <property type="gene ID" value="B7C42_08040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="15083" checksum="1B636A32B52A2B3F" modified="2017-10-25" version="1">MSLAAEVAPYIATVLGTGFATSLVNGWMNRRNEARRVEADARRTDTEAEVTLSAALGAGYERLIAGIETEREELRRERQGLREELVTAHSDNRLLREEIAASRQEVAALRNELGAVKRDLQRVLAGKPPIGDWLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTJ7</accession>
    <name>A0A231GTJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent monooxygenase, oxygenase subunit HsaA</fullName>
            <ecNumber evidence="3">1.14.14.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hsaA_5</name>
        <name evidence="3" type="ORF">B7C42_08050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.12" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778607.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39875">
        <property type="protein sequence ID" value="OXR39875"/>
        <property type="gene ID" value="B7C42_08050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036383">
        <property type="term" value="F:3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="235"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="388" mass="42469" checksum="0E14DE5E1B18943D" modified="2017-10-25" version="1">MSNDVLSRVRALLPGIRARAEEADRQRRVPAESIAELADAGVFRLLQPKRYGGLEHNPAELYESVRAIAGACPSTGWVASVLGVHPWQISLFEERAQDDVWKAAPDALVSSSYAPTGELVEVEGGYRLSGRWSFSSGSDHCQWVLLGTLCFHGAGGPPEYLTALVPRSDYTVEDVWDVIGLSGTGSNDIVIDDAFVPAYRAYSSLEQDRLVGPGQAVNTSPIYTLPFGMVFSYAITNAIVGAAQGAYTAHVERMKERVRLSYGGQKVAEDPFAHVRVARAAGEIEAAELTLDHNVAEQMRYVEAGEKIPERIRLRARRDQVLGTERALRAIEILFENSGGHSIKRGNPIERHWRDAHAGTVHVINDVERALAMYGRGEFGVPIDAGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU24</accession>
    <name>A0A231GU24_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_07847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40092">
        <property type="protein sequence ID" value="OXR40092"/>
        <property type="gene ID" value="B7C42_07847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="212" mass="23184" checksum="978ECD560854E776" modified="2017-10-25" version="1">MPEQDEAGRKRRGRGRRPAAEVRAEALDAAGALLLDSGMGAFTIEAVAEKAGVSKTTLYKWWPSKGALALDGYFHAVESALTFPDTGDIEADLTAQLRSFVHVLTHTRAGRVIAELVGQAQTDPELSTALLERYSGPRRRLAVEAMRRAQQRGQLRTDIDPEIVVDQLWGACYHRLLLPNLPLGEHFATSLVTNVLYGTAAPSDGRKPVRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU59</accession>
    <name>A0A231GU59_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_38</name>
        <name evidence="1" type="ORF">B7C42_07745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40163">
        <property type="protein sequence ID" value="OXR40163"/>
        <property type="gene ID" value="B7C42_07745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="27439" checksum="F6ED1E32CE5BB970" modified="2017-10-25" version="1">MSEKSGSLSEMLDLTGEVAFVTGAGRGVGATIAQFLAAQGAAVAVNDFHLERAQTVADRITAEGGNAIAVGADITDYEQVDEAVRVISERLGWTSVLVNNAGNGGVKPAVPQPFWDSGPAQWAPFLEVNLYGVLACCRAVVPGMIEARHGRIITVVSDAGRVGEAGLEAYSAAKAGAAGLMRSLAHSLGRFGITANSVALGITRTPAMDAILADPDLVTRVLSRYPVRRVGEPADAAAMISFLASTAGSWITGQTYPVNGGFSVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUD0</accession>
    <name>A0A231GUD0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041936.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40192">
        <property type="protein sequence ID" value="OXR40192"/>
        <property type="gene ID" value="B7C42_07706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="20143" checksum="DAD22835417EEFB4" modified="2017-10-25" version="1">MRLARVFAVLVIVGVGAAAFRLSFATLRDLAKLAHIPASDAWLFPLIIDGTIVQATAGALVLAKSAERKFFTWVLVVGALVSVAGNSIHAVAAGKELPAWLCAIVAAIAPISLLVDTHGLAVLFRASQSNPVPAPAPAVAEAEEDAPTAVEEFEEPAAPEPSASVVPAAPVIPVAQPIPVSRPVQPPLLPVSVPIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUD4</accession>
    <name>A0A231GUD4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40237">
        <property type="protein sequence ID" value="OXR40237"/>
        <property type="gene ID" value="B7C42_07662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="19493" checksum="B4EADD2E65CB8F47" modified="2017-10-25" version="1">MTAVIEERTFVPAHEHEQEISSLLDFMVKHLMGQGRTLRYALVGASEADRIELPREVHEALVQVVAAMQAGKAVTIAPRSMTLTSQQAADLLGVSRPTVIKLIERGELPAERVGSRHRLKLDHVLAYQEARKIRQYDAIAATSVDIDPDEDPEVLRDRLKRARSEVAARRRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUE5</accession>
    <name>A0A231GUE5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TraG-D_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40250">
        <property type="protein sequence ID" value="OXR40250"/>
        <property type="gene ID" value="B7C42_07675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TraG-D_C" evidence="2">
        <location>
            <begin position="452"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="633" mass="67411" checksum="A1E35602E547DAA9" modified="2017-10-25" version="1">MDRSVKAPSMSGGEYHELAGIGAIAVGVPSLIELAGAAVWSAPMYGGPKQDVPFRNPVGLGWHLLATHDLAWTGEATAALGTLVGGGLAALAGTAIGVRWACRRCAAARADRRYRRGRPAHVALGKATVGRVDRQPIDTQARFMGRGAELDDLCWEAVQAKAIDLGVQLGEGQVPGVLIGRAVADRRELWASYEDLHLDIWGPRSGKTTSRVIPAIMDAPGAVVATSNKRDVVDATRGHRSTLGEVWVFDPQSVAEAEPSWYWNPCEWVRGNGKGAQARAAELAGHFADATEADGDAFFEPEGEDLLTALILAAALAEKPITQVFEWITKQDTTSAAVRILDDHGYGLVAGALAEQLNAPDKQKGGVFATAKKMAAILKYEEIRQWVCPAQRGERPRRSFDVAQFVTSKDTLYLLSEEGKASGGALVTAFASAVAAAGKAEGVRANGRMPVPMLIVLDEAANIVRWRELPKQYSHFGSRGIVVLTILQSWAQGVRCWGSEGMSALLSAANVLTLGAGLKDTGFLRDMSELVGAHHELVTSVSRGRRPDSGTESTSRTSEVTLTPSDISAMPKGRALVFVSGHRPTLVRTTPWMERGDADLIRDSIAAHAPDQSSTPAGPHLRAVPTNEEDNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUY3</accession>
    <name>A0A231GUY3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enoyl-CoA hydratase echA6</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">echA6_2</name>
        <name evidence="1" type="ORF">B7C42_07558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40392">
        <property type="protein sequence ID" value="OXR40392"/>
        <property type="gene ID" value="B7C42_07558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="24503" checksum="2365690BB7462C2A" modified="2017-10-25" version="1">MTLAIHRGRVWRVRLDRPQAANALSSELVEALHDALEEAAAARPEALVLEGNSRHFAAGFDLTGLSRESDASLAHRFLRIGSSLERLATAPYLTVAVVEGAAIGAGADLVAACDHRLAGPDARFAFPGARFGVVLGTARLRAITDPAIFLGGDPVTAAAAGRLVTGTPGDLSGILDAWARIDPATRPALLAETRPVHDPDAALAALTRSVIAPGLHDRLTIYRRRVLSARIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVE3</accession>
    <name>A0A231GVE3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">drrB_11</name>
        <name evidence="10" type="ORF">B7C42_07351</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40542">
        <property type="protein sequence ID" value="OXR40542"/>
        <property type="gene ID" value="B7C42_07351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="16"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="26818" checksum="74C248D28C8639D2" modified="2017-10-25" version="1">MSTITMPAPLSDASKMLGRNFTHITRSPVTIFNAALMPVVMMLIFVYVFGNAFDVGGHYIDYATPGLILLAISYGLSGTAVSVSSDMAKGIINRFKVMDVSRSAVLIGHVAATMLTNLVAIAAVIGVAFALGFRPPASATDWLAAIGIMVATSFAASWLTVALGMAAKTPESAGMSVVPLIMLPFVSSAIVPADKMGQGIRQFAQYQPFTPIIESLRGFLEGHPSGGYTAAALAWCAGFAVVGFLWSRVTFNKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVE5</accession>
    <name>A0A231GVE5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909778.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40600">
        <property type="protein sequence ID" value="OXR40600"/>
        <property type="gene ID" value="B7C42_07285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="60" mass="6219" checksum="1925DCBED9079079" modified="2017-10-25" version="1">MCFGAEIAYLLLWAATTRGAPPAVQMLRRLVAALCVLLIGGFITVLALGGGAGERYSHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVG1</accession>
    <name>A0A231GVG1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40578">
        <property type="protein sequence ID" value="OXR40578"/>
        <property type="gene ID" value="B7C42_07387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="17648" checksum="B7DE4C55AC7F9608" modified="2017-10-25" version="1">MRTILAAPAWRASRRAPLLWAAGPAIFWAFVLVGGLMWAVLDGSHRGWALALVAAAVVAAGFSVVVVPMWRYAVHRWEVTESAVYTRTGWFNQESRVAPITRVQTVDTHRGPLERMFGLATVTVTTASSAGAVRIAALDLEVAERTVNRLTDIAAIHREDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW50</accession>
    <name>A0A231GW50_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40826">
        <property type="protein sequence ID" value="OXR40826"/>
        <property type="gene ID" value="B7C42_07110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046282">
        <property type="entry name" value="DUF6319"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19844">
        <property type="entry name" value="DUF6319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="26463" checksum="1C3AAD8DEFC6049B" modified="2017-10-25" version="1">MSSPRTKPQPLSDTEIRQIAAELADGRPPMVWFTPAAVGVSEGRSGKVIALGDPADGDFLQVRPTGSKDVMSFSPTEVTLAKPARKDKRTTTSETTGATSPATRKDTAVSMSSSVTAPPAPPTPAPVPAAASKAPAPQPASDPKPAAKPAATPARAPREKPAAAARKSKAPEVTVTLAGTADGEWTVDVVHGKKRTIKGLSVPGASVAQAAKLLHPEVAEVVDSVLDAVRDSQRAKVEQLQAELEQARRLLDELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWA7</accession>
    <name>A0A231GWA7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_34</name>
        <name evidence="1" type="ORF">B7C42_06993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40858">
        <property type="protein sequence ID" value="OXR40858"/>
        <property type="gene ID" value="B7C42_06993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="27300" checksum="D25253C76BB4349A" modified="2017-10-25" version="1">MIRKLTPPQAVAEPTVGPGADLTGQVALITGGSSGLGRAIAMGLAVAGAAVVVAGRRREASERAAAEISTRTGTIAEGVSCDVTDEDSVHAVVRTILDSHGRLDVLVTSAGIQARGGLDTLDAGTLRDCLDVNVVGTFLACQAVVPTMRQAGYGRIVTLASALGLVGAAGRAGYAASKGAVVQLTRSLAAELAGTGICVNALAPGPFRTALNDNIDDDPYVREFLDHQVPMRRWADPEELVGAAVLLASPAASYLTGAVLPVDGGWTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWA8</accession>
    <name>A0A231GWA8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Copper transport protein YcnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ycnJ_4</name>
        <name evidence="6" type="ORF">B7C42_07021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40886">
        <property type="protein sequence ID" value="OXR40886"/>
        <property type="gene ID" value="B7C42_07021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012691981" evidence="4">
        <location>
            <begin position="29"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="5">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="531" mass="55302" checksum="3984603A50445C15" modified="2017-10-25" version="1">MSLDPRGALRCWFVLLVAIVAPVWAAGAASAHAVLVSTTPESGTHVDTAPGELRLQLDEPVTLIAGSAQLIDSGGQRFALSAARLDDGQRRVVLVPAEAVPDGAYLATARVVSADTHVVSLSTQFTVGAVTAQGRFAQHSPTGIEQYLNSPTRAVTYLGLILSAGLYAAALWVWPTVVRRRRFRVLYRVGIAIFVAGFVCRFLVLVAQQDGGLSAISVTGARTVLETPLGVAAVIAASASIIAFALVTGAARAVVGAGAVQAAAAVVAVTLDGHGGSVQGWPWSFAGTLLHVYGITVWLGGVVVVAFVLRGVRNRGRWHAVAVGHVVAAVAGGIVLAVLQVHPPAALVHTTYGLALVAKVVVALGVVSLGYLSLRWFRRTDTIVGRPRTLVLETALAVVVLAVTSVLATLAPAKDTYTTDLATTLDFGAAQVLHVGIDSIRHGPQRLTVDYAPANTSVTQSDSATVSVDLSSESANVARLPVSLGRPVTERGSLVWRSDQLIVPAPGKWKVTVRFDSGTGPKLASFHYQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWE0</accession>
    <name>A0A231GWE0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MscS family protein YkuT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ykuT</name>
        <name evidence="8" type="ORF">B7C42_07085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780106.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40801">
        <property type="protein sequence ID" value="OXR40801"/>
        <property type="gene ID" value="B7C42_07085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="31066" checksum="73EAB8746A1388BC" modified="2017-10-25" version="1">MTTTLAAGTGAEFTSWLRGSGLEIVLLIVGAMLFSRFATFVRDRITRRIDSGFQSSDSLVRTEAAKHRHALAQVITWVVLVIVYFLVSLEVLRRLGFQLSGLVAPAAVLGAALGFGAQRIVQDLLAGFFLITERQYGFGDVVRIAVTGQSEPAEGTVEDVTLRITTLRNPDGEVITVPNGQIVKVTNLSKDWARAAIDVPVPATADITKVNEILHEVGAKAFQDRRLKSLLLDEPTVMGLEDLTVDQMNIRMVARTLPGKQFDVGRELRVRVAAALRREGLSETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWS2</accession>
    <name>A0A231GWS2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ahcY</name>
        <name evidence="9" type="ORF">B7C42_06802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780325.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41032">
        <property type="protein sequence ID" value="OXR41032"/>
        <property type="gene ID" value="B7C42_06802"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="252"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="281"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="360"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="493" mass="53665" checksum="65B1CDED363DB6C3" modified="2017-10-25" version="1">MTTSELSAQTNLTPDVRNGIDYKVADLSLAEFGRKEIRLAEHEMPGLMALRREYAEVQPLKGARISGSLHMTVQTAVLIETLVELGAQVRWASCNIFSTQDHAAAAVVVGPHGTIDEPKGTPVFAWKGETLEEYWWAAEQMLTWPNEPANMILDDGGDATMLVLRGAQFEKAGVVPPEDESHSTEYKVFLNLLRASLAADAGKWTAIAESVQGVTEETTTGVLRLYQFAAAGELTFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESMAGQGARVQVTEIDPINALQALMDGFDVVTVEQAIADADIVITSTGNKDIIGLDHMKAMKDQAILGNIGHFDNEIDMAALENSGATKLNIKPQVDLWTFDSGKSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKPEQYDNEVYRLPKVLDEKVARIHVEALGGTLTKLTKDQAEYIGVDVEGPFKPEHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX20</accession>
    <name>A0A231GX20_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentalenene oxygenase</fullName>
            <ecNumber evidence="4">1.14.13.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ptlI</name>
        <name evidence="4" type="ORF">B7C42_06745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.133" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41149">
        <property type="protein sequence ID" value="OXR41149"/>
        <property type="gene ID" value="B7C42_06745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="29"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="868" mass="94297" checksum="D2333DD42583782D" modified="2017-10-25" version="1">MGYRTTGRVGNVPGVHIAMFMDYHPATLGGVQTAVAALRHGLERAGHRVTLFVAPLSGAAMPSDDGVVELAPLAGAVVNGFPMVLPTARNAALIDAAFAARGPVDLVHTHTTYGVAIAGMKAARRHRIPLVHTAQSRDDAFIEHTAPAPYLSALALRILHGRFVIHPTRMPRGAQSRAARHAWHTIVGQGQAADRVIAPTRHFADLLLDHGLTRPIRVVSNGVDDALFDDQRAPAARDIDAPLRLIWCGRLSAEKRLLESIEAVRRVPDCLLDVYGEGELSARAAAVIAEHGLSDRITLHGRVSQQQCLDAMAAADVLLFPSWGFDTQGMVLLEAIATGLPVLYCDPDLTESVPAGGGLRAGDASPAALAEAIGVLATDRDRLLAMRAEMTRHRDSVRQSGRIDAIVEVYRQAQADIEPAAQRPVPQRLSDVPTAPGALPLIGHSLRALRDAPGFVTSLAELGPIVRIRFGRKTGYVLTTPELVREVGLGDAELNRDDLREAIADVAGGSVNVLRGAEHKLRRRMIAPALRQSRLAEYTVTAAELADTWSAALPAGGRVDLMDEAHGLILDTVSSTLFTAEFSAAARHRIRDNVPWLLSQVILRTALPPQIRRLRVIANRRWERKARHLRAAIGAAITEYRRRDEDFNDVVSALIRHTDPETGARLSDDHIIDEAILMLAGGVGSMASLTGWLWHEVMRRPDIAERVRAELDDVVGVGPVRAEHIGELVYLKQVVSETLRFWGPWISAGNASGPVTVGGLTIPDGTAIMFSPYLVQHDPRHFPNPEAFDPDRWSPVRVAEIDKQANLSFGVGRRRCLGDHFALLEITLASAALLARWRPEPDPAYVVRASNRDFVLSPSAIPVTLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX73</accession>
    <name>A0A231GX73_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41178">
        <property type="protein sequence ID" value="OXR41178"/>
        <property type="gene ID" value="B7C42_06774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="28978" checksum="ECEA4980565B77D5" modified="2017-10-25" version="1">MLGRFILLSLIPAWVWIGLLAVAALFGLATVLVVATDSSGSAASADFRYQCDSALGPDEQSTTDTGTSIGTTETIRPSDIPTTNPFAELTIAPDDSEVSGWERDCLTAMQSAPYQLPALRTTNAGAAVDCASQIALAEVGQSMAAATLVKNVIYQASAVWTTGRCGVLGAAPGDPAASAGRPGAEPAPAAAGCGRSAQSPGTDVSSVVVLPDTIAAQGLCGQRVETDRVSAGDLVFWDYRSHMPTRVGIAVGPSAVVTADPISGGVLETGMPSGAGVRVKRVLGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX80</accession>
    <name>A0A231GX80_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ald1</name>
        <name evidence="3" type="ORF">B7C42_06881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.48" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41111">
        <property type="protein sequence ID" value="OXR41111"/>
        <property type="gene ID" value="B7C42_06881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050061">
        <property type="term" value="F:long-chain-aldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="85" mass="8987" checksum="560EA53147DA987E" modified="2017-10-25" version="1">MTVYAAPGQPNSLVTVDSRYGHYIGGQWVAPIKGNYSENISPVNGKPFTEVARGTEEDINAALDAAHAAAPAWGKTSTTERANIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXA3</accession>
    <name>A0A231GXA3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41236">
        <property type="protein sequence ID" value="OXR41236"/>
        <property type="gene ID" value="B7C42_06634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="16163" checksum="23F960A30D3E38E3" modified="2017-10-25" version="1">MTFFNNLDAVRAATGAELGVSAWIDVPQNRIDVFADATEDRQWIHTDSAAAAAGPFGTTIAHGYLTLSLVSALLADLLAVGDVAMAVNYGLNKVRFPAPVPSGSRVRGHGRLADVTDIPGGLQTTTIVSVECEGVGKPVCVAEVVTRFHDRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXH7</accession>
    <name>A0A231GXH7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41211">
        <property type="protein sequence ID" value="OXR41211"/>
        <property type="gene ID" value="B7C42_06609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="176" mass="19968" checksum="66176DE33C994A34" modified="2017-10-25" version="1">MLTVHDRPFRPEDRTQAGHWEGDLIVGKDQSSAIGTLVERQTRMVRLLHLSSRDSESLHTALTARMRDLPPALLRSITGDRGTEMAPHVTIARSLRAPIYFCDSHSPWQRGSNENANGLLRDYFPKGTNLNIHSPEHLLAVEDELNHRPRHILQDRCPAELFTALLASENQSVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXQ6</accession>
    <name>A0A231GXQ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-malyl-CoA/beta-methylmalyl-CoA lyase</fullName>
            <ecNumber evidence="6">4.1.3.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcl1</name>
        <name evidence="6" type="ORF">B7C42_06495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.24" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036504776.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41352">
        <property type="protein sequence ID" value="OXR41352"/>
        <property type="gene ID" value="B7C42_06495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043959">
        <property type="term" value="F:L-erythro-3-methylmalyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050083">
        <property type="term" value="F:malyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="33911" checksum="40897EAF4A727782" modified="2017-10-25" version="1">MSTRRSVLAVPGSNLRMIDKAKGLPADEIFLDLEDAVAPPAKAAARANIVAALNSPGWGKQIKVVRVNDWTTEWTYADVISVVEGAGRDLDAILLPKVLDGAQVRALDLLLTQLEKANGLEVGRIGIEPQIENAQGLRNIDEIATASPRVQTLVFGPADFMASINMRTLVVGEQPEGYEPGDAYHHILMTILLAARAHGLQAIDGPYLQIRDLDGFRRAASRTAALGFDGKWVLHPTQVEACNEIFSPRQADYDRAEEILDAYAYHTSTAGGARGAVMLGDEMIDEASAKMAQVVAEKGRAAAMTRTTSFVPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXW5</accession>
    <name>A0A231GXW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41457">
        <property type="protein sequence ID" value="OXR41457"/>
        <property type="gene ID" value="B7C42_06348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15321" checksum="A9EF6FA25836C2B3" modified="2017-10-25" version="1">MRETADRGAVAIVGADGPLGSVIDRVCEQQSVAVVGRVTRRGWVIDGPPSVVIDVGSAENLWDSAEFCQRWGSALLYCAANRDPDGFTRLRELSAAVPVGLVTTLARPQTRLELVAAQLLGVAGELASAAPGWYPMADRFREAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXX8</accession>
    <name>A0A231GXX8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiseptic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">qacA_12</name>
        <name evidence="7" type="ORF">B7C42_06524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780441.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41381">
        <property type="protein sequence ID" value="OXR41381"/>
        <property type="gene ID" value="B7C42_06524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="495" mass="52045" checksum="807AF68E5EE05735" modified="2017-10-25" version="1">MTSQRNPWLALTALVVGFFMILLDMTIVAVANPAIMQDLHTDINKVIWVTSAYLLTYAVPLLVTGRLGDRFGPKNVYLAGLAVFTLASLWCAVSANVEMLIAARAVQGLGAALMTPQTMAVITRTFPPDKRGAAMGLWGGVAGLATLVGPILGGVLVDWQGWNWIFYINVPIGVVAFALAVWLVPNLETHQHKFDFVGVVLSGVGMFLLVFGIQEGNTRDWDAWIWTMIIAGLVVLGLFVVNQARNKDEPLVPLSLFRDRNFSMSSVAIAAMGAAVTSLMVPAYFYLEAVREYTPTRAALVFAPMAIVTGLTAPFIGKISDRMPPRILPTLGFGVFALTVFGFAALMKPDSSIVLFLVVAGVAGLSNSCIWAPLASTATRNLPIHQAGAGAGVYNTTRQVGSVLGSAAISALVSARMSAQGLGSGQFGEGGGTGMGHIPEQIIDKFSTALGQAMILPGAILLIGVVASALFVGGSAKKQQEAEAGTEPEKAGIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY84</accession>
    <name>A0A231GY84_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor SigF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigF_5</name>
        <name evidence="9" type="ORF">B7C42_06453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41560">
        <property type="protein sequence ID" value="OXR41560"/>
        <property type="gene ID" value="B7C42_06453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="52"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="219"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="31394" checksum="1C5C0D07F8E35136" modified="2017-10-25" version="1">MSTDTTAASTRSATAGDDGGRNSYDGIEDSFRALAELEATDPRRARLREQIIADCMPLAAHIARRYEGRGQSREDLQQVANLALVLSVDRFDVSRGAPFLGFAVPTIMGEVRRYFRDSGWAVKVPRRMKELRARISQHSLVLSQQLGREPSSHELARALDVPVEDVVQATVAANSYLCDSLDETQSAESDSPTPLGARLAVDEPRYEFTEDAITVKPLIEALPEQERKILIQRFYESRTQSEIAALHGISQMQVSRILSRVLSGLREQALAEPARPRHLRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYV9</accession>
    <name>A0A231GYV9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator KipR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kipR_7</name>
        <name evidence="6" type="ORF">B7C42_06146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41804">
        <property type="protein sequence ID" value="OXR41804"/>
        <property type="gene ID" value="B7C42_06146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="62"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="26190" checksum="7C74575688DC007F" modified="2017-10-25" version="1">MLERATLVMDLFQAPDRHLTLGQIAVRTRLPRATVHRIVRQLIALEWLTHGTNGYALGRRVRTWNADTARLSRLRACAAPILHELLLATAAVVHLGALDGGEVLYLDKLGGRAATAVPTRVGTRVAAHRSTLGRVALAQLPPEDVDARVTDVEPGFDLAALHRRLHRIGSRATDYDDDEFGSGLSAVAVAVDATAAVGVVCDRPAALRRIAPRVRAAAAEIRGGLTPRSRQVSDHHRPRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ00</accession>
    <name>A0A231GZ00_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41837">
        <property type="protein sequence ID" value="OXR41837"/>
        <property type="gene ID" value="B7C42_06179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011309501" evidence="1">
        <location>
            <begin position="31"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="205" mass="19683" checksum="64234D8940822DAB" modified="2017-10-25" version="1">MRSISSLVRAGVLAPVAVATVFCMAAPANAAPVSVNWSCKGTIFGVGQTSSMTTSVTGTAPSSAASGSAVAITLTPGASSVPSSASGFTVNNISNLKMTFPTPANSTLVSATASGGTVAGTVATSGGNVVLTVPGPIAGGTSFTPPAVTINVTAGTPGTPITSKYAGTSYTSPGMTMTTNVALVGNVATSCYPNPSPTLTTTAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZG3</accession>
    <name>A0A231GZG3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41997">
        <property type="protein sequence ID" value="OXR41997"/>
        <property type="gene ID" value="B7C42_05981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021299">
        <property type="entry name" value="DUF2871"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11070">
        <property type="entry name" value="DUF2871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="15541" checksum="2D1BA8EA737E624A" modified="2017-10-25" version="1">MKQLYWAAVGYTALGLPSGLVYRELTKAHEFTGKTELAVVHTHLLALGTLFFLIVLVLEHQLALSNTRAYRWFFTVYNIAVLWTVSCMTIIGTRTVLGHGESTPLAELAGIGHVLLTIGFVLFFVTVHQAITASREEVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZT9</accession>
    <name>A0A231GZT9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42105">
        <property type="protein sequence ID" value="OXR42105"/>
        <property type="gene ID" value="B7C42_05704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="32" mass="3246" checksum="B10A3429646A8EEB" modified="2017-10-25" version="1">MTTVLATMWPIGAAAGIGFLCGCYLVALGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0I5</accession>
    <name>A0A231H0I5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42352">
        <property type="protein sequence ID" value="OXR42352"/>
        <property type="gene ID" value="B7C42_05551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="338"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="44111" checksum="86750E3D18E9A817" modified="2017-10-25" version="1">MPVAVNSAPSSLAARILDRLPQFAERVLASGLGTSASAAELPADHFVEVLPAIYGCAHAFLHAMAQQREFTRAEIAAFVQPVIERHAEDRLPLPLLMEAVHHSAQQVLREAVAVSGPAEVDQLIEFGSRTLELLMHINLITVEGYAAVEHSIYHPEREARRALCAALVGGQAAEEQAARADTALAERYSVLAVQVRTDPQPAAAANLVVRRRIRILQRVLERVAGPTALHTFDGETAVVLLPGVLGWPEGAGAELAGELAEQFGADVIVAETPGTRRESVPEAAHQAAEVAQLAHMSGRPTGVYRLDDLLLEYQLTRPGVARDRLAERIEPLHQAPHLMETLDAHLRHGSDRKAAAAEIHVHPNTFSYRLRRIGELTGADPSDPNGSRLLSAALVAHRLRPAPGRPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0N0</accession>
    <name>A0A231H0N0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42331">
        <property type="protein sequence ID" value="OXR42331"/>
        <property type="gene ID" value="B7C42_05530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="12557" checksum="65A39FF26D82FE54" modified="2017-10-25" version="1">MMSMLFAQTALLAQNTTTNPTGPEFGKASPLGLVIILVLLAGTVLLIRSMNKHIKRLPADFSREHPEPDQEADEGTEHGVAGEGDDAADGDAPRQSHDDAANGSGRGDSGPSTPPPASGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0T9</accession>
    <name>A0A231H0T9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">egtC</name>
        <name evidence="3" type="ORF">B7C42_05602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42401">
        <property type="protein sequence ID" value="OXR42401"/>
        <property type="gene ID" value="B7C42_05602"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="29704" checksum="267DE3158E6293D3" modified="2017-10-25" version="1">MCRHLGYLGPPAPVGELLTRGTHSLRTQSWAPNDMRHGGTVNADGFGVAWWTDEGAASRYRNSAPIWTDPAVEEVLPQLSSPAVLAAVRSATVGMPVERTACAPFTDGGWAFSHNGVIQNWRTVLPVVAKQFGSPDLLDAESATDSAALWVVLRAALDGIGALSSSFEGRSESDARLRAVAAAVTATVRAVLAPAPSARLNLLLGDGETLWATTVHHSLSVLVTDEVAVVSSEPYDDDPRWQAITDRQVVTVRPGLLVVEPLDAAPSTLSAGPDESERARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0X7</accession>
    <name>A0A231H0X7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778144.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42524">
        <property type="protein sequence ID" value="OXR42524"/>
        <property type="gene ID" value="B7C42_05300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="15026" checksum="36CC0DEF7B8CC41F" modified="2017-10-25" version="1">MPKYLLLKHYRGAPASVNDVPMDQWTPEEITAHVQYMEDFAARLQTSGEYVDHRALSPQGTFVRSDGEGRPPITDGPFAETKDLIAGWMLIDVETYERALELAGELSEAPGAGGKPIREWLELRPLLTAMPTVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H145</accession>
    <name>A0A231H145_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_05353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42576">
        <property type="protein sequence ID" value="OXR42576"/>
        <property type="gene ID" value="B7C42_05353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556653" description="VWFA domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="34"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="637" mass="65510" checksum="B0F091ABEAD12547" modified="2017-10-25" version="1">MSRLRKLLTLGAAAAAVVLTAVPAHAQQQPEYAPTMLVLDASGSMRAPDPGGGTKLDAAKAAVHSFVAAAPPRSRVGLTVYGTGTGSSDAEKTAGCADVRTLRGADILDRAAVNTAVDGIEASGYTPIGAALRAAGEALPKEGPRSIVLVSDGEDTCAPPDPCEVARELERQGARIVVHAIGFGVDGPARKQLTCIAQQTGGTYTDAADGTSLERVLPRVSQAALRTYTPIGAPISGAAAYRDAPIAAPGQYLDTIAQHETKYYALDVPQGAMAYFSATVAFPHMRQKQSGNDNSVLYLRVYGEDGKDCNVFGFEQVVNTSDGVALTVTKAWDGATKTDSGSDSAANACRGGGRYYFAPEWHGVADNMPQQMPMELLFGIEPAADDPGPPASTTPTAFTPPAGSTVAVTGGGSFNAATTLDGSGSYSDTLQRGESVFYRVPLGWGQGLAYRVNFSDSDKHGLDGLSRATTTLYSPIRTEIDHDFAGYNGESAAMPAGDPLATLPVRYSNRTAGAGKGTEQSLAGWYYIAVSVSASNVEGLGAPVPIRLDVTVGGAPEPGPHYESATAKGIFGEHETQSPDASSSANSGGRSPASAASESGDGVSSTVLVAVIAGVVLLGLLLGALVVIRSRRKKSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1J8</accession>
    <name>A0A231H1J8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_14</name>
        <name evidence="2" type="ORF">B7C42_05061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42724">
        <property type="protein sequence ID" value="OXR42724"/>
        <property type="gene ID" value="B7C42_05061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="30715" checksum="E0466343825FA87C" modified="2017-10-25" version="1">MAISTYMPKGLSHFVRFYRRRGLLLARVEGLGFVLAFIWQVLSSIPLTLRRYRDETLRIISDMTWGRGSVIVGGGTVPMMIVLGLVMGASVAVESFTMLNILGMGPVSGIVSAYATTRELAPIVAAIGFAAQAGCRMTAEIGSMRISEEIDAIEALGLRSVPFVVTTRVIAGAISIVPTFLIGLILSYLACRGLITLVHGQSAGVYDHYFFQFVSGFDVIAAVLKVAIFATVVILIHSYYGFFATGGPEGVGIASGRAVRASSVAIVAIDMVLTLMLWGFNASIDFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1M9</accession>
    <name>A0A231H1M9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ada_Zn_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42746">
        <property type="protein sequence ID" value="OXR42746"/>
        <property type="gene ID" value="B7C42_05083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ada_Zn_binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="16307" checksum="4B355CFE4853C2BA" modified="2017-10-25" version="1">MREECRAGEGGVAARDYVLLDSDAVPYRSPTAGTVGGHRRQRIYGRLDCPAALRALRRGNYAAYRVFFADEATAVAAGYRPCARCLPEAYRRWKSGRSDAALPPPDRRPGRTDVPVHQLQGGQQDQRESGGQIVLGQHAEDRQAAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H247</accession>
    <name>A0A231H247_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prcB1</name>
        <name evidence="3" type="synonym">prcB</name>
        <name evidence="4" type="ORF">B7C42_04810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042599.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42924">
        <property type="protein sequence ID" value="OXR42924"/>
        <property type="gene ID" value="B7C42_04810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5011322904" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023501610" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="43"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="28865" checksum="BCB9E959D3046A59" modified="2017-10-25" version="1">MGYALSSFSEYLRENAPELLPGNGFGRASGGNGSAGDLAPHGTTIVAVTYRGGVLIAGDRRATQGNLLASRDMEKVYITDTFSAAGIAGTAGVAVEMIRLFAVELEYYEKIEGVPLTFDGKANKLSKMVRDNLPAALQGLAVVPILVGYDLEATDPERAGRIVSYDVVGGRSEERFGYTATGSGSMFAKSSLKKTYSRDMDEDRALRIAVESLLDASDDDTATGGPDLQRGIFPTAIVINAEGALEVSDERLEQIARSIVDERVAEEGSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2E7</accession>
    <name>A0A231H2E7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778687.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43012">
        <property type="protein sequence ID" value="OXR43012"/>
        <property type="gene ID" value="B7C42_04898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="13730" checksum="1C4E2EA2D21502AC" modified="2017-10-25" version="1">MSHIENGRAPETASVAELVGTTTEQLSRLVREEAKLAVVEAQGKAKRLGAGAGMLGAAAVLGLAVLGALVAAAITALALVLPVWASALIVAAALAVAAGVLGLLGRTSIRKGSPPIPEQAAANVREDVAVIKERAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2M2</accession>
    <name>A0A231H2M2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43100">
        <property type="protein sequence ID" value="OXR43100"/>
        <property type="gene ID" value="B7C42_04986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="34" mass="3935" checksum="147BDC132989F254" modified="2017-10-25" version="1">MWMLFLLAVGLLVLTVALVRVPLRGEVRRRGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Q3</accession>
    <name>A0A231H2Q3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43129">
        <property type="protein sequence ID" value="OXR43129"/>
        <property type="gene ID" value="B7C42_04551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="121"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="393" mass="41094" checksum="4350B16AA8C621D3" modified="2017-10-25" version="1">MTSRKSNEKKSHTVRTGLIGILIVVALVVVAVGFDTISSWFSSSRTYSAYFGDTGGIVEGDKVFLAGVQVGKVKHIEIEGDKVLMKFDVDGPALGSDTEVAIKTLTVLGRKSLQINSRGAKKLSPDHPIPIDHTTTPYLLTDALGDLSTTVSDLDLGQVTDALGTLSRTLDQTAPNLGAALDGVGRLSNSVASRDKMVQDLFHNAESLTKVLGGRSEQINKLLLDSNTLFEALNQRRQAIQTLLTNLSSVTSNIAALIDENQQQLRPVLQQLNSVTDLLNRRKDDLAKAILPASQYITSLGESVASGPFFKAYIMNLLPGQYLQPFIDAAFKDAGLDPSALGGPRPAPAPAAAPGPAAAPTPAPAPAAGPAPAPALPGLPPLPGLPPLPGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H366</accession>
    <name>A0A231H366_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009539.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43311">
        <property type="protein sequence ID" value="OXR43311"/>
        <property type="gene ID" value="B7C42_04733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="9318" checksum="3A7A6E52D052904D" modified="2017-10-25" version="1">MVYPAYMPGHKVEEQMLHLRPLAESGRMMMFAFDPGGNLRMGLEDPLRTVGHTNTDMIKQAIALADEVGRPIATYQNALDVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3C1</accession>
    <name>A0A231H3C1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sulfoacetate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sauT_1</name>
        <name evidence="3" type="ORF">B7C42_04740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43318">
        <property type="protein sequence ID" value="OXR43318"/>
        <property type="gene ID" value="B7C42_04740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="415"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="514" mass="54728" checksum="790DEC88DBAABE8E" modified="2017-10-25" version="1">MTSIRGALGRLWEADDDAPMIQQGDTWFTWGEVRVLAETLDAELAAAGCNGGSRIGVVLDNRMESIAALIAILGKGRTVITLNPMQPVARLSADMAEAHPHAVLAPESLWNEPLFRSAAETGAMIGFAVDGARVVATTEAGAATPPEADGAIGDAVGVEMFTSGTTGPPKRIPLTWRQLEAALTAVHGHTGAAGPADRKLLTGRVALVTLPIVHIGGLWGVLQNLAEARPFVMLPRFTVEGWCAAVKEHQPKVAGLPPAAMRAVINADVPVEDLASLRAITAGTTFVNPDLADEFTAKYGIPVLIMYGATEFSGAIAGWTKPMHAQWWTKKRGSVGREMPGVKLRAVAEDGTVLPLGESGRLEVSSSQTGNGKHEWVRTSDLGHLDEDGFVYIDGRADDAIIRGGFKVHPETVADALRAHEAIADATVYGRDDERLGKVPVAVVELRDGAAEVAEDELKTFCRDRLTAYEIPVRIYTVAELPRSVSLKVDRRRLLEMISEMDESAAAPAVASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3C6</accession>
    <name>A0A231H3C6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase/lyase DddD</fullName>
            <ecNumber evidence="1">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dddD_1</name>
        <name evidence="1" type="ORF">B7C42_04718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43296">
        <property type="protein sequence ID" value="OXR43296"/>
        <property type="gene ID" value="B7C42_04718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="819" mass="87038" checksum="2C601E1452B90143" modified="2017-10-25" version="1">MTVDSTRHDTPAGPLDHLTVIDLSTTLPGAQATMFLADAGAEVIFVEPPSGSRLRALPGWPALGRGKKSITLDLHDDADAATLRGLLRTADVLVTTMRPAAATRLGVDPATVGALNPRLVSAAITGWGSTGPFKDLKGYEALVTAKLGIMYGKRQTTTRPGPSFVPSPFASWGAAQTAIHGILAALLEREDSGAGQHVEADLVRGIATMDTWQWFSELVVNRWPDAFVPVSAFDDEGNPNGHLIYPLLVTPTKDGHFIQFAQTEPRLFLALMKELDLTWMFTDPKWAGLPQLEDVALRIELWEIMLERASARTLAEWQQVFDTNPDLSAEVFRTPAEALHHPQLAHDGRVVTITDPDLGEVTQPSTLVHVNGAALAPPRLAPRLGADTDETVRRVAESSSVPTPSGAARADLPLAGITILELGSMFAGPYAATLLADLGARVLKVEPLGGDTIRGLVPFPEAGGAKVMQGKESIALDMHSPEGLAIVHRLAQQADVVLQTYRAGAAERAGVDAATLTALNPRLVYLCAPGYGIDGPYGGKPAYAPSIGAATGLGLTDVPDVVARADNLDEVKAAVIRLYAAAANLSVQADGVAALGAASAMLLGLLARRLGRPLGTLTTTMIATGTHALVDRNVDYPGRGEALRPDPDMYGYSALYRLYRAADGWIFLAAPLEHEWADLVAAMEPHLRLAEDPRFATAIARIDNDDALAEALARVFATRAKALWEKELGAADVGCVAVAEQVAEKTLQEDEFFEAGYGVLAVHPTFDVHRRLSPATTFSRSRTKADGGCLTGEHTDALLTEIGYDTAKIADLRARGIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3E9</accession>
    <name>A0A231H3E9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43384">
        <property type="protein sequence ID" value="OXR43384"/>
        <property type="gene ID" value="B7C42_04251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="28761" checksum="1B76CAAE6E38F362" modified="2017-10-25" version="1">MDDVTLFVGTSGWQYRDWRGVLYPPGVPQRLWLERYATAFATVESNNAFYRLPSREVFAAWRERTPDDFVVAVKASRFLTHVKRLREPAEPVQRLLEHAAGLGDRLGPILVQLPPTLRADANLLDDCLRQFPSTVRVAVEPRHESWWTPRIRAVLEERGAALCWADARSRPVTPLWRTTDWSYLRLHSGLARPQPRYGRRALTAWAHRLADTFGPADGYVYFNNDPGGAAVHDAVVFAGLATDAGLTVTRTDVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M3</accession>
    <name>A0A231H3M3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43435">
        <property type="protein sequence ID" value="OXR43435"/>
        <property type="gene ID" value="B7C42_04302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="89"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="32713" checksum="0A9B485B5C9491A2" modified="2017-10-25" version="1">MVGVGQGGTRRWVMAGVLAIVVAAIGFGSVEPAAPDGHAGPAVPGLSIQPAEAGVPMRIGYGREADTFGDLYLPAGGPLSGSSGRCPVVVLIHGGGWSQYRDLTQFSAQARQLAESGVAVWNVEYRRVNGAGGWPVTLTDVDDAVAALSTVVQQRAGGRLDLDNVHLAGHSAGGQLAAWVAGRRTDGEAASRGLRIRSVTLMAAVLDLDYAVAHGNDGFARKLLGGLPDEVPDRYRYASPIVNLPRGVHITAVHGDADRVVSVEQSRRYAEAARRAGDPTDLHILPGVGHAEFTDPGSAAWSVARVAILASVAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Q4</accession>
    <name>A0A231H3Q4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline transport system permease protein OpuBB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">opuBB_2</name>
        <name evidence="6" type="ORF">B7C42_04259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063010704.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43392">
        <property type="protein sequence ID" value="OXR43392"/>
        <property type="gene ID" value="B7C42_04259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="22343" checksum="B66F9A95F7449495" modified="2017-10-25" version="1">MNLWNYIRGRGDTLAFLTYQHASLAFQTVLVGTIVAVLIAMAVYRLPLLSQLSLTSSRVALTIPSLALLALLLVPFGLGVVPSFIMLAFFAALPVIGNAIVGLRSVPPSVVESARGIGFSRTRILLTVELPIAWPVILTGIRVSTQMIVGVAAIVAYVLGPGLGSLIFNGLSRLGGANALETAATGTILIVIVALVFDALLVLLGRLTIAEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Q8</accession>
    <name>A0A231H3Q8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">pdxT</name>
        <name evidence="7" type="ORF">B7C42_04342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43475">
        <property type="protein sequence ID" value="OXR43475"/>
        <property type="gene ID" value="B7C42_04342"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="23323" checksum="59DBDAB62ED41D47" modified="2017-10-25" version="1">MKPTIGVLALQGDVREHFHALAACDAEPVSVRRESELESVDALVLPGGESTAISKLLEVFGLLDPLRARLRAGMPAFGSCAGMILLASEVLDTRPDAQSLSGIDMTVRRNAFGRQVDSFETDLDFTGLDDPIRAVFIRAPWVERAGAGVEVLARVPHRPRPGTVVAEGPSVGDPQDAAGRIVAVRQGSVIATSFHPEVTGDLRVHRLFVDSVRAAVGAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3V7</accession>
    <name>A0A231H3V7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SERPIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43548">
        <property type="protein sequence ID" value="OXR43548"/>
        <property type="gene ID" value="B7C42_04416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="SSF56574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERPIN" evidence="1">
        <location>
            <begin position="262"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="380" mass="38952" checksum="6FC1B7BC55325CED" modified="2017-10-25" version="1">MQPSLAPDVAAANLLTGKWCAAAGSDDFVVSGCGIWPLLALLAATAGEPARGELTAAAGIPAASAHDAAITLLRRIEAAESVRAALGAWVRDDIALRDEWIRTLPPGTVAALRGPDGLDDWARRHTDGLIDRFPARIGAATACALATAVVVRTAWRQSFHADVLEPSSGPWQGHRGPALARYSTDLGDASVLLAGTPVSRVVVRGASDLDVHLLLGEDGVTAPAVLAAGLGALDGSVETHRPGLGTVAPGLEVRQVTAVSDTLRIQVPPFVVRSTHDLLREPELFGLTAATTAADNPFPGISPVALRVTAAAQDVCARFTADGFAAAAVTAVLMEPTGMPPAPAAALMIAVNVDRPFGFLGVHRPTGLVIVAGWIATPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3W1</accession>
    <name>A0A231H3W1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shikimate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aroE</name>
        <name evidence="9" type="ORF">B7C42_04402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43534">
        <property type="protein sequence ID" value="OXR43534"/>
        <property type="gene ID" value="B7C42_04402"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="7">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="6">
        <location>
            <begin position="125"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="8">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="28617" checksum="6E07B260223936E6" modified="2017-10-25" version="1">MADNGTRSGRKAAVLGSPIAHSRSPQLHLAAYRALGLDWTYERIECTGEQLPGLVDGLDSDWVGLSVTMPGKVAALNYAGERTERAVLVGSANTLVRTASGWRADCTDVDGVRGGLQGGGVESVRRSVVLGAGGTARPALLALSELGAETVTVVARDAERAEPTLALARELGLATEFSDFDADRVRAACARADAVVSSVPAAGAAVVADAVAAAPVVLDAIYDPWPTPLATAVRRAGNTVISGLQMLLNQAYGQVEQFTGRPAPRAAMAAALDLRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4J9</accession>
    <name>A0A231H4J9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43767">
        <property type="protein sequence ID" value="OXR43767"/>
        <property type="gene ID" value="B7C42_04002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="29610" checksum="69CDFDF265C5F89A" modified="2017-10-25" version="1">MRETRNARRCAKTGFALLPAASREVYRLAKPSYGPLNPLQRGISSDESRADWNRYDVEGQQTVYAASTEQGAYGELLAPLKPKLPRRASHYFDDVASDDELESLIKEEWQSSGYRPPRELNMLWLSEYRLYHLTLPTHGWFIDIEAASSLSAIARYAPIALVERGLREVTVAELRGGERWLTTAISTRIWQITLDDDSLAHGIAYGSRHGSEWDCWAIWLRRTGLAHTSNGLVTSADPGAEVLPPPINPALQAILTAYDLTVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4M7</accession>
    <name>A0A231H4M7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GDP-mannose-dependent alpha-mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mgtA</name>
        <name evidence="5" type="ORF">B7C42_04084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43849">
        <property type="protein sequence ID" value="OXR43849"/>
        <property type="gene ID" value="B7C42_04084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="187"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="366" mass="38916" checksum="BF0308914707F642" modified="2017-10-25" version="1">MNGVVNSVLQVLTHLDRNGHDALVIAPDTPRGQAAAPRSYGRFPVIRVPAVMVPRISSLPVGLPQPLLTSAIEDFDADVVHLASPFLLGAGGAAAALRLDLPAVAVYQTDVAGFAASYGLGAAQRAAWAWTRRIHNRAARTLAPSSAAMADLERHGIARVHRWARGVDAVRFTPGARDAGLHARWADGDRLVVGFVGRLAPEKHVERLAALADDPDIRLVVVGDGPERAQLQRLLPTAVFTGELGGAELAQAYASLDLMVHPGEHETFCQGVQEALACGTPVIGPDAGGPRDLIAHCRNGYLLPVDRFAELLPSAVAALRDPALRARFAGAARKSVLHRTWPAICTELMGHYHEVIGGREVLHRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5A2</accession>
    <name>A0A231H5A2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Epoxyqueuosine reductase</fullName>
            <ecNumber evidence="6">1.17.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">queG</name>
        <name evidence="6" type="ORF">B7C42_03590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44034">
        <property type="protein sequence ID" value="OXR44034"/>
        <property type="gene ID" value="B7C42_03590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="368" mass="40606" checksum="262A5EA9AC2E8553" modified="2017-10-25" version="1">MSSTDREPTEAGRYAEHPTVKNLAAQPRRAPDPVLTAARLREICLAAGADDVGFVSVDDPKVAEEREHARGILPSARTFVAFCIRMNRDNLRSPMRSLANAEFNHADDETNGVSRRITRALEEAGYRAVYPAPGYPMEVEQFPGRIWVLAHKVVAEAAGLGVMGIHRNVIHPKFGNFILLGTVVTDAVVDEPSTALDFTPCLECKLCVSACPVGAITNDGGFDFQACYTHNYREFMGGFTDWAENVADSADRDDYRERVTRGESFSMWQSLSFKPNYKAGYCMAVCPAGEDVIGAFIDDRKTHLDEVVRPLQNKSETVYVLPGSAAEEHVTRRFPNKTPKPVGNGFGDDVNDLLDQIGPRPRRRDTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5H0</accession>
    <name>A0A231H5H0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitomycin radical oxidase</fullName>
            <ecNumber evidence="3">1.5.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mcrA_2</name>
        <name evidence="3" type="ORF">B7C42_03804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777551.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44243">
        <property type="protein sequence ID" value="OXR44243"/>
        <property type="gene ID" value="B7C42_03804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="454" mass="48385" checksum="9ED0AC4395054209" modified="2017-10-25" version="1">MTNSTFPAELPTVTGPVFRPGADGYDAEVSGFQTAYTHRPDLVVGAVHAEDVRAAVEFAARHGLPVAVQATGHGLSVPAVGGVLISTRRMTDVRVDPEARTAWVAAGVQAEALIAAAVAHGLAPLNGSSPSVGVVGYHLGGGLGILARTFGYAADRVRVLELVTADGRLRRLTPGDELFGAALGSGGNFGVVTGMELELFPIAEVYGGQLTFDTPLVEPALEAWRQWTAEVPEEMTSAITMMTMPDVPVIPEPLRGRYLATVNIAFTGSAADGERLVRPLREVGARIADDLRTMPYRDTHGIYRDPNFPHAYTATNALLSDLTADAASAFLDVTGPEAPVAAVAGFRHLGGALRRPGPAGIAMDHREAEYNARVITMPNSDGPDLRGYHDLVAKTLAPWTIGHNLNFLYGAGEWADENQTRAGYAARTYDRLRALKSAYDPANLFRFNRNIRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H640</accession>
    <name>A0A231H640_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">27-O-demethylrifamycin SV methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.315</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.315" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777543.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44232">
        <property type="protein sequence ID" value="OXR44232"/>
        <property type="gene ID" value="B7C42_03793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23758" checksum="77D19D61B0CB129B" modified="2017-10-25" version="1">MGAWDWDHNAFYHRTLLRQLPQHCERILEVGCGAGALAAELARRADRVDAVDRSAEMIEAARRVVPDNVACAQADILGHPLPEAAYDAVVSLTTLHHMPLEQVLPRLAHTLRPGGVLAVIALPRADPLRELPAEVTAALAHRAFGLTFAALRATGRGTWYAHEPTHAAMPVVLDPPLTTREVARRARDILPGARVRRLVFWRYLLRWDKPGQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6L4</accession>
    <name>A0A231H6L4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug efflux protein YfmO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yfmO</name>
        <name evidence="8" type="ORF">B7C42_03277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44488">
        <property type="protein sequence ID" value="OXR44488"/>
        <property type="gene ID" value="B7C42_03277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="42993" checksum="73AE19DA4D8A1080" modified="2017-10-25" version="1">MSITLSSPTATEATTTPKTKQPKSVWAVAFASVIAFMGIGLVDPILKPIGEQLHASPSQVTLLFTSYMLVTGVAMLITGVVSSRFGAKKTLLAGLAIIVVFAALAGSSGTVGQIVGFRAGWGLGNALFIATALATIVGAASGGVARAIILYEAALGVGIAAGPLVGGFLGGFSWRAPFFGVAVLMAVAFVAIVVLLPEMPKPAQHTSITAPFKALRHRGLLMVSITALLYNYGFFTLLAYTPFPLNMGTYSIGFIFFGWGLLLALASVVFAPRLQRMFGTVPMIATALALFAADLAAMAIWADHKPVLIVGTVLAGLFLGVNNTLITEAVMISAPVERSTASAAYSFVRFVGGAAAPYLAGKLGEHQMALPFWVGAACTAVGVLVLLGGRSALSHVDDHDPAEHSPAEAEAITVGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6N0</accession>
    <name>A0A231H6N0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cysteine protease YraA</fullName>
            <ecNumber evidence="1">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yraA_2</name>
        <name evidence="1" type="ORF">B7C42_03320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44531">
        <property type="protein sequence ID" value="OXR44531"/>
        <property type="gene ID" value="B7C42_03320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032633">
        <property type="entry name" value="ThiJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17124">
        <property type="entry name" value="ThiJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="25415" checksum="1EE8B93895A64225" modified="2017-10-25" version="1">MSKPKILFIVSGATYWVLKDGTRYATGYWAEEFANPYKMLTDAGYEVVVATPCGTTPNVDMMSLRPAMAGGEQAALDLEAIIRDAEAMRRPLELSDVRLEDYVAVYLPGGHGPMADLAFDADAGRLLTAQLESGNPLFIVCHAPSAMLATRIHGVSPFQGYNVTGFSNEEEEAVGLASRATWLLETDLKEKVKVNYSRGPIWEPYMVEDRNLVTGQNPHSAAVLGGRMLEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6V6</accession>
    <name>A0A231H6V6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kshA_4</name>
        <name evidence="10" type="ORF">B7C42_03266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775861.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44477">
        <property type="protein sequence ID" value="OXR44477"/>
        <property type="gene ID" value="B7C42_03266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="46129" checksum="50C2CCF1728FE396" modified="2017-10-25" version="1">MAETAQRSGKVREIDVGSTPTRYARGWHCLGLAETFRDGKPHAVQAFGTKLVVWADSNDELKVLDAYCRHLGGDLSMGEIKGDSIACPFHDWRWGGNGRCTSIPYARRVPPLARTRAWTTLERNGQLYVWHDHEGNPPPDDVTIPYIEGPYTDADGNPLEERNNDWTPFTWNTMLIEGANCREIVDNVVDMAHFFYIHFAFPTYFKNVFEGHVATQFLETKGRPDIGMAAKYGGETLLKSEASYFGPSYMINPLTNIYGGYQIKVQLINCHYPVTQDSFVLQYGLSVEKPKGIDDETAEKLAKSMTDFFGDGFLQDVEIWKHKSKIDNPLLCEEDGPVYQLRRWYDQFYVDVADIDPKMVQRFEFEVDTTKANEHWEAEVAENLRRKKEEDAAQQDPAVKQEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Y5</accession>
    <name>A0A231H6Y5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777192.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44783">
        <property type="protein sequence ID" value="OXR44783"/>
        <property type="gene ID" value="B7C42_02737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="1">
        <location>
            <begin position="2"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="32352" checksum="D7638A1F4D22D974" modified="2017-10-25" version="1">MSGAAGPAVVAALGEDVDRLLAAEPKVRADEPDSVHQMRVATRRLRSVLRSYRKVFHRDEIDAIRTELRWLAGLLGIARDAEVRADRFAALLDEYPDVQRHLGRRLVSAERAAYTDAHRTVLRELDGERYALLRARVVGLRTDPPLRRKRARRDADRVFTAAVRADLRRLKAHVDAERDVEETDRVEALHDIRKAAKRLRYSAEAATDILDGPAEDLARRAKKVQGVLGDHRDAIEALATITARAEIVRGHGADTAPYDLLCAAEVEAARTALAQYPSLVEFLNYDYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7C4</accession>
    <name>A0A231H7C4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44834">
        <property type="protein sequence ID" value="OXR44834"/>
        <property type="gene ID" value="B7C42_02788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_7" evidence="1">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12304" checksum="337278B8EEC95145" modified="2017-10-25" version="1">MNPEILTQPGYTWTDVADAPSRELFPGIRLRHLWKGENGAHAHVLEMDPGTSWPRRDVHEPGPEEVYVLTGTFNDGARDYAAGTFIHAPAGSWHIPASETGCTLFLFYPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7L7</accession>
    <name>A0A231H7L7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase</fullName>
            <ecNumber evidence="4">1.14.99.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ncsB3_2</name>
        <name evidence="4" type="ORF">B7C42_02792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.49" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777139.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44838">
        <property type="protein sequence ID" value="OXR44838"/>
        <property type="gene ID" value="B7C42_02792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="45685" checksum="743031771D8C13FD" modified="2017-10-25" version="1">MTDTQPLVLDPSAADIQGELARIRARGPVAEVVLPGGVPAWSVTDAAVLRQLLTDPRVSKDAHQHWPRFVDGEIGPDWVMFPWVAARNMLTTYGEQHQRLRKLVAPAFTNKRTQDLRPRIEAFVTELLDELSAAPDAEIVDLRAGFATALPIRVIGELMGVPAGMDEQLRIHADGILDTSLDPAEVGAHFGALFVLMEELLRHKRENPGDDLTTVLMNAHDDADGSRLDEQELRDTLLLIITAGHETTANLLDHSIIGLLTHPGQRKAAIAEQTPWSEVIEEGLRWNAPLAHMPMRFAVEDIDIAGSSDFPGVRINRGDVIIASLAGAGRDRKVHGDNADVFDAGRRSKEHLAFGYGVHHCLGAPLARLEAAIALPALFERFPDMELAVDPAELRPIPSIVTNGHREIPVHRMAHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7N0</accession>
    <name>A0A231H7N0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44845">
        <property type="protein sequence ID" value="OXR44845"/>
        <property type="gene ID" value="B7C42_02799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013099209" evidence="1">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="21274" checksum="7B463BF69F516FD4" modified="2017-10-25" version="1">MNRRAVLSPFVTISICLLTMGVVGCGGSAGEAVGDDQAAGDMRSVGTASPAATSAALSNMAMPGVAMADARSYFATSGGIDGYYFTTPAGRWHCAIVVGGEPHMAGCQPATNTGAGIGVKGAPTVESHYSHKQVAPDTIMIERGSEPRFAVLGQAVFRQTPNEAKVLPYNTSLSADGFTCTARDSGVSCRDDASGKGFTFSTEGFAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7S4</accession>
    <name>A0A231H7S4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">vapC_1</name>
        <name evidence="6" type="synonym">vapC</name>
        <name evidence="8" type="ORF">B7C42_02850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44895">
        <property type="protein sequence ID" value="OXR44895"/>
        <property type="gene ID" value="B7C42_02850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="130" mass="13963" checksum="5D7F9A07E49E3EC5" modified="2017-10-25" version="1">MIVVDASVWVDLLRGVLPSGYADRIRIAGCVSPPHVDFEVGSALIRLARRGELEFDQARELIAAFSTHPVERIREPVDSVTAVGMIDNATYADAGYIALAQRLACPLMTLDDGMQKAARIHGVEVMGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H869</accession>
    <name>A0A231H869_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL</fullName>
            <ecNumber evidence="1">1.3.1.104</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabL</name>
        <name evidence="1" type="ORF">B7C42_02904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44947">
        <property type="protein sequence ID" value="OXR44947"/>
        <property type="gene ID" value="B7C42_02904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="26409" checksum="45277C84CAD91228" modified="2017-10-25" version="1">MDSQRIVLITGASRGIGAQTARILAGRGDHVVLNYREKRRRASDLADAIAADGGVATPVGADLSDPEAAAAMIEEIRTRFGRLDVLILNASGGLEHGAAPDYAMTINRDAQVRLVRLALPLLAPGARIVFVTSHQAHFHGRKPTPPDYEPIALSKRAGEDALRAMVGEFDSRGIGFTVVSGDMIEGTIIVRLLERRDPDAVAARTEHGALPTIDEFATAIADATTADTEPGHTVYVGGADYLTTAPDPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8K5</accession>
    <name>A0A231H8K5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribonucleotide transport ATP-binding protein mkl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mkl_2</name>
        <name evidence="5" type="ORF">B7C42_03097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45140">
        <property type="protein sequence ID" value="OXR45140"/>
        <property type="gene ID" value="B7C42_03097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="36300" checksum="260F61DD5BD2E69F" modified="2017-10-25" version="1">MGVEVRTEGVTKSFGSQRIWQDVTLTLPTGEVSALLGPSGTGKSVFLKSLIGLLRPERGSIYIDGTDITTCSNKELYEIRKLFGVLFQDGALFGSMNLFDNVAFPLREHTKKSESEIRQIVMEKLELTGLLGAEGKLPGEISGGMRKRAGLARALVLDPQIILVDEPDSGLDPVRTTYLSQLLIDINAQIDATILIVTHNINLARSVPDNIGMLFRRQLVMFGPREVLLTSEEPVVKQFLNGRMVGPIGMSEEKDEAQMAREQALADAGHYDNGTEEIEGIIPQMKATPGMPVRQAVERRRRRVLEIMHTLPHSAQQSVREGLELGMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8M3</accession>
    <name>A0A231H8M3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fused isobutyryl-CoA mutase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Isobutyryl-CoA mutase</fullName>
                <shortName evidence="6">ICM</shortName>
                <ecNumber evidence="6">5.4.99.13</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">P-loop GTPase</fullName>
                <ecNumber evidence="6">3.6.5.-</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">G-protein chaperone</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">icmF</name>
        <name evidence="8" type="ORF">B7C42_02334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-methylpropanoyl-CoA = butanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:13141"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="EC" id="5.4.99.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IcmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.13" evidence="6"/>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45209">
        <property type="protein sequence ID" value="OXR45209"/>
        <property type="gene ID" value="B7C42_02334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047727">
        <property type="term" value="F:isobutyryl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034784">
        <property type="term" value="F:pivalyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02050">
        <property type="entry name" value="IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033669">
        <property type="entry name" value="IcmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="5 6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="201"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="338"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="853"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="858"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="970"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1088"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119338" checksum="4519FB5F613ACB1E" modified="2017-10-25" version="1">MADLHVPVHPVRFVTSAALFDGHDAAINIMRRILQSQGAEVIHLGHNRAVHEVVDAVLTEDVQGVAVSSYQGGHVEYFEYLASALREAGAGHVQIFGGGGGVIVAEEIERLAAAGVRIFSPEDGQRLGLPGMINELVRACDVDLSAEPAAIEAVLAGERYALARTLTCLQADALPAAHLNELRAAATGRTVPVLGITGTGGSGKSSLTDELVRRLRTDQQDKLRVAILAVDPTRRRGGGALLGDRIRMNSLDSEHVYFRSLATRGAHELPTNIDAMILACKAAGFDLVILETPGIGQGDAAIIDHVDISMYVMTPEFGAASQLEKIDMLDFADVVAINKFERRGAEDALRDVSRQLVRNREAFGSAPEDMPVFGTSAATFNDDGVTALYQHLAGLLGARGLPLETGVLPRVDTRASTRFAQIIPPGRVRYLAEIAETVRDYHAETRRQVAAAQRVQRFEQVLAELPAGAADDSANTNAPAPKDISAARRTVTGLLARASEELSPESAALLRDWPATVESYRGEEQVVRVRDREIRTPLRRITLSDNSIPRVAVPRFTDHGELLRFLRSENLPGRFPFTGGVFAFKRDNEDPARMFAGEGDPFRTNRRFKVLSEHAEAKRLSTAFDSVTLYGHDPAPRPDIYGKVGTSGVSIATVDDMKALYDGFDLSAPSTSVSMTINGPAPTILAFFLNTAIDQALQRFREANGREPSGDEAADIRARTLATVRGTVQADILKEDQGQNTCIFSTEFSLRMMADIQEWFVRNGVRNFYSVSISGYHIAEAGANPISQLAFTLANGFTYVEAYLARGMAIDDFAPNLSFFFSNGMDPEYSVIGRVARRIWAITMRDKYGANDRSQKLKYHIQTSGRSLHAQEMNFNDIRTTLQALIAIYDNCNSLHTNAYDEAVTTPTEESVRRALAIQLIINKEWGLAMNENPLQGSFVIDELTDLVEEAVLAEFERISERGGVLGAMETGYQRGRIQDESMRYEHRKHDGTLPIIGVNTFRNPNGETHQVLELARGTEAEKQSQLRRTEEFVTAHREPAQAALARLEAAARGDDNVFDVLMDAARVCTLQQITDCFFTVGGQYRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8U9</accession>
    <name>A0A231H8U9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">groS_2</name>
        <name evidence="3" type="synonym">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">B7C42_02509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513506.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45384">
        <property type="protein sequence ID" value="OXR45384"/>
        <property type="gene ID" value="B7C42_02509"/>
    </dbReference>
    <dbReference type="GeneID" id="66719074"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="10860" checksum="051A5A7042116100" modified="2017-10-25" version="1">MASVNIKPLEDKILVQANEAETTTASGLVIPDTAKEKPQEGTVVAVGPGRWDEDGEKRIPLDVKEGDVVIYSKYGGTEIKYNGEEYLILSARDLLAVVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8W9</accession>
    <name>A0A231H8W9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776605.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45404">
        <property type="protein sequence ID" value="OXR45404"/>
        <property type="gene ID" value="B7C42_02529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="11227" checksum="658152FCE9AFD37E" modified="2017-10-25" version="1">MTYQPDRSSATDPAEQRRVDEKIAARMGISVEELHEIDRRVAEDIAARDAVPAEQRIVDDNPKFTKGFGPVTPENEIQPGEIREHYRNSEAASPPDEQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H941</accession>
    <name>A0A231H941_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513423.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45474">
        <property type="protein sequence ID" value="OXR45474"/>
        <property type="gene ID" value="B7C42_02599"/>
    </dbReference>
    <dbReference type="GeneID" id="66718984"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="10427" checksum="6ECC7AAD5313B9BF" modified="2017-10-25" version="1">MGELVAVPEAIRRYGDTAAAMATETLSAGTVNQAVAIAAAVPVFGLIGQDFLATYALAQANHLSSVVELATVHAGTAVTAHQSAATYATTDQDNADLLGGIGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H966</accession>
    <name>A0A231H966_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45398">
        <property type="protein sequence ID" value="OXR45398"/>
        <property type="gene ID" value="B7C42_02523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="11005" checksum="7A177EB63BDB4ACE" modified="2017-10-25" version="1">MSTFKADPAALRAIEPRYNDVSDRVITAVQNLKRIVEAEGRCWGDDEIGEKFAKGYVDPAGKAVTTGGNLGAILSSMAGNMRSAAETLQAQDQSNAGAIAQTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H979</accession>
    <name>A0A231H979_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45286">
        <property type="protein sequence ID" value="OXR45286"/>
        <property type="gene ID" value="B7C42_02411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011282197" evidence="2">
        <location>
            <begin position="26"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="380" mass="38365" checksum="262B3049D246D0AD" modified="2017-10-25" version="1">MATTSLPLATAAAVATILASGTASAAPADQPSVPTTPAQPGATNEAPAQGDNNGQGQNAPGTQENAPQNGTQQNGPQQNNNQPNGTQQNGPQRNGTPQPGVTTPNQPGVTTPNQPGVTTPQPGVTTPNQNTPKPDQNLASPTQPGVTTPRVAPLPVPGQSGQVQPAVVPDQPTPNGQADQLKPGQQSPDQTVGTPNKPQSQNGGNADTLRSQQGNSTPSQQAQWTSPSLQAAPAAPVVQMNGPHTEVGANVDGGGLLPGYVANTHHFSNLDGYVGTVGYSTPNGVGDAGVSVEFVEANKVKITSYTHATGFDDLKSENYVDTTEANAAKAAVEGWIKQQPGGAAALDAAAQIGRLPQGDFAPQTVNVAGATTQWGGTVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H995</accession>
    <name>A0A231H995_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45593">
        <property type="protein sequence ID" value="OXR45593"/>
        <property type="gene ID" value="B7C42_01885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="720"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="787" mass="84070" checksum="82107F2DBC33C274" modified="2017-10-25" version="1">MTAQVATGHATAGVDSASPAVATGDGNLPPELTSFVGRRSQVGEVGNLLAKSRLVTLTGIGGVGKSRLALRVAHTVKADFSDGVWLVELGDMRDPALLADVVATAVGLRTRAAGPVFDLLIRYLSARDLLLLLDNCEQVIDAVSTLTEALLKTCPRVRILATSREGLDVGGESVFAVPPLPIPDPALESTPRAAREDAVALFADRAAAVVPGFEIGADTRACVARICARLDGLPLAIELAAARLRTMSPEQILSRLDDRYGLLTRGRRGAPMRQQTLAWCIGWSYDLCTPHEQRLWRRLSVFAGGFELDAAEQVAGGDLTPPEILDSLSALVDKSILIREEVDSAVRFRMLETVQEYGRDRAEESGEHADSARRHHDWCLRLALRAEAEWIGPHQLQWVARLERDLPNLRKALEFAVSESCDDAVRMTAALFPFWVMRGRPGEGRRWAARALLGTDGATPAVDRARALFAAGSMAALQGDVADAGDKLAQLRRLAEGGTHPVIGALLAHGEGSLVLMTGAPEPDHAHDLVARAVAVYEASGALSLQLDALISLGLSYALLGDTSQATGYFERVLTITGSAGETMLRAWALWAAGYLAWRGGEPDRAGDLLAEGIRSARLMADPLISATCTETLAWVAAGQRRYRRAAVLTGAADSLFGRAGSSGFPFPALLVHHDDCAHVARDSLGDNAFQASLREGAAMTVDSAASFALGERTDTSASTREPATVLTKREREVTALVTRGLTNKQIAARLVISQRTAEGHVEHILTKLGFTSRAQIAAWASEHRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9G6</accession>
    <name>A0A231H9G6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ORF">B7C42_02623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513401.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45498">
        <property type="protein sequence ID" value="OXR45498"/>
        <property type="gene ID" value="B7C42_02623"/>
    </dbReference>
    <dbReference type="GeneID" id="66718961"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="19372" checksum="BE5FC30A5693CFAC" modified="2017-10-25" version="1">MSRIGKKPISVPAGVEVTIDGQQVSVKGPKGTLSHTVAEPITVTKAENGELEVGRPDDERRNRSLHGLSRTLINNMIVGVTQGYEKKMEIFGVGYRVQQKGSNLEFALGYSHPVPIEAPEGITFQVEAPTKFSVSGIDKQKVGQIAAVIHGLRKPDPYKGKGIRYAGEVVRRKVGKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9J6</accession>
    <name>A0A231H9J6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45406">
        <property type="protein sequence ID" value="OXR45406"/>
        <property type="gene ID" value="B7C42_02531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="25068" checksum="9E248F3A087D9529" modified="2017-10-25" version="1">MGCLWASATQNSAGFIRKMSGGDPLSDPSWTAIDTWADRLAAAYADRVPAQQAVQQWIGVAEHPEGGGIPAGASVRRAESLAALYELVNPGGAPPPNPLIQDGMYPDGTPPDRSQGWGPLVGAPLRRYATSTTSAVRFLPIVKAGRHIGYLWASVENDAADYLPLRSAGKTAHIAAGLWQLRLSQGYKQHVPPLQTLQDSRHHPEDRLSGMIQPNAVEDELPSLERLKALSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9J9</accession>
    <name>A0A231H9J9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Iron import ATP-binding/permease protein IrtA</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">irtA_2</name>
        <name evidence="11" type="ORF">B7C42_02653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45528">
        <property type="protein sequence ID" value="OXR45528"/>
        <property type="gene ID" value="B7C42_02653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="57"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="382"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="415"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR45528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="633" mass="68037" checksum="5111597E5FEEBAF2" modified="2017-10-25" version="1">MTVQTVDPTEPEAARQAPTATPDTPLEPDRVALKQQRRADGLARKQVLAPVNGALSLASLVVVVSSICAVVPFILIVEACRELLSAPIDEDRVWTLVIAAVVVLVLRGLLQAAALVWTHMVDAKFQLTLRQLLAAKLSRVPLGWFTDRSSGEVKRFLQDDVEALHYLVAHARLEFVGAVTVQLVALVYLFTVDWRLTLILLVPLVLYTRGLAAMMGKAHQERFAVFDANERAIEQSIIEFVDGIQVVRAFGRARKAHSTFQRAVDNTAESLLAWKTPMTKLQSAAEILLTPALLMLVVVVAGVGFADLGWTDPVDILPFLLLGIGLGSALLGIGFGGQALRAGGAAALRLHQLQQTPELEVRADGDDAADAADDAAATGLAVRFEQVSFGYRADRTVLREVDFELAPGSITALVGPSGSGKSTLARLLPRFYDVTAGRITIGGKDVREYSTTQLYRTVGFVLQDVRMIRGTIRDNIALARPDADADAVERAARAAQIHDRILELPRGYDSEVGVDAVLSGGEAQRLSIARTLLADTPVLVLDEATAFADPESEAAVQDALAVLVAGRTVLVIAHRLHTITGVDRILVLDNGELAETGDHATLSVAGGLYQRLWEQNQASVDVLGVSDSEGELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9L3</accession>
    <name>A0A231H9L3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45426">
        <property type="protein sequence ID" value="OXR45426"/>
        <property type="gene ID" value="B7C42_02551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023840">
        <property type="entry name" value="T7SS_Rv3446c"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03931">
        <property type="entry name" value="T7SS_Rv3446c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="483" mass="50267" checksum="4B76AAD8A79E30DC" modified="2017-10-25" version="1">MPREPAWKGELMSTVDLILTDSRLWARSESTHWDGAPSVVPASDGTSLVVGEPLQPPSPAVSVVRLAAADRIAFVPMLPTVADAFAAIFGAVLTNLRLPTACERLTVVSPSEWGTRRRAALEAGARRLVGEISVEPLALRVAGLSASTSQQQRIAVVELNSLTTTVTLTGRSGTETWIEACEYEPTIGSADLAEGRGVEAVVDVVDRLLGGRKPSYLVVVGAADPALLDAMRAELSRRYGFGVDLRAMSGVDLVRGGPAMPAAAEPAQFAPQTPWVGSLHEHAAATAPPPKRRTPLLIGAAVVAVVVAAVVAAVVLTRSGDESPTAQPTAARPSAVASPTAAPAPPAETFGRVGAVIPAGWHITNRSGARVDIYPNDGARERISLVQKDLAPGSGVEDVAATLETQIAKRPAGTVGPLQRNVIFGGRPGLSYEETPGDGTTVRWQVLVDSGLQVSVGCQYPTGDWQPIAAVCEKFVGDLRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9N9</accession>
    <name>A0A231H9N9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_E_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45733">
        <property type="protein sequence ID" value="OXR45733"/>
        <property type="gene ID" value="B7C42_02025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="31584" checksum="82E5BE76E2192B38" modified="2017-10-25" version="1">MDYRVDVCEVPPQALLRLPRAIRTDRPGADITAGMRELFATVARSGLTASGPTAITYTDTERSAVATSVDFRVPVEPAAELSLASGAEVLVTPGTTVARACHHGGYRDLGAAYRSLAEWVDRNAYRIIGPPTEVYLVGPDEVSDPRQLVTEVRLPVAPSPTIVTRVLADSGTALDRTRNALRSNGFTILAEVDLNTARYDGRTRRLAHHTILEVCRRNLLVAELADDDGADMIVPHPVVVRERCETVVVEAVDPAIWARALGNEELLTLAADSRRHLIAAIDDLAATATAHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9S2</accession>
    <name>A0A231H9S2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rplB</name>
        <name evidence="9" type="ORF">B7C42_02677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498168.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45552">
        <property type="protein sequence ID" value="OXR45552"/>
        <property type="gene ID" value="B7C42_02677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="8">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="30146" checksum="70C9CD42CB55AC8D" modified="2017-10-25" version="1">MAIRKYKPTTPGRRGSSVSDFAEITRSTPEKSLLRPLTKSGGRNAHGRITTRHRGGGHKRAYRLIDFRRLDKDGIPAKVAHIEYDPNRTANIALLHYADGEKRYIIAPKGIAQGTRIESGTGADIKPGNNLPLRSIPTGTTIHAVELRPGGGAKLARAAGMSIQLLGKEGAYAVLRMPSGEIRRVDVRCRATVGEVGNAEQSNINWGKAGRMRWKGRRPTVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRKPNRPSDKLIVRRRGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9W3</accession>
    <name>A0A231H9W3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45536">
        <property type="protein sequence ID" value="OXR45536"/>
        <property type="gene ID" value="B7C42_02661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="21702" checksum="8783BAEFEA314E1F" modified="2017-10-25" version="1">MPESAVPLLWSRKSELSEVLGFYRGLGFEVTYEQTRPYVYGAVTRGGYELHFTARPDGVDAELSCLILVDDVGAYHGEFTAALRARLGKVPAKGVPRITRFKPGQTRFTMVDPAGNHVLVIQRDEPRELEYGGSAELEGLARVLDNVRILRDFKNDDAAALRVLEVGLRRYGPTATPEDLERAQRERAELSGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA44</accession>
    <name>A0A231HA44_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative quinone oxidoreductase YhfP</fullName>
            <ecNumber evidence="2">1.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhfP_2</name>
        <name evidence="2" type="ORF">B7C42_01889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784092.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45597">
        <property type="protein sequence ID" value="OXR45597"/>
        <property type="gene ID" value="B7C42_01889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014188">
        <property type="entry name" value="Acrylyl-CoA_reductase_AcuI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF1">
        <property type="entry name" value="PTHR43677:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02823">
        <property type="entry name" value="oxido_YhdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="34174" checksum="6B4C89D1D8BC6FD4" modified="2017-10-25" version="1">MSQSFNAFVVNKSEAGFSAGVQQLTLDDLPAGNVTVRVQYSSVNYKDGLACLPESPVVTSYPMVPGIDIAGTVAESSDPRFAVGQEVIAIGRGLGTDHWGGYAEYARLSGDWLEPLPQGLSLKEAMALGTAGFTAALSIQRLEQNGLRPGTGRVLVTGATGGVGSTAVSMLAGLGYEVVASTGKTAEHGYLEELGASEILSREAVSAQVPHPLEAELWAGAVDPVGGDTLAYLLRTTRYGGSVANCGLTGGPAVSTTVLPFILRGVNLLGIDSVMCPEDVRAAVWLRLGTDLKPKNLLESISHEVDLNGIPAVAGQILTGAVKGRTIVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA60</accession>
    <name>A0A231HA60_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45738">
        <property type="protein sequence ID" value="OXR45738"/>
        <property type="gene ID" value="B7C42_02030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="24970" checksum="BD8D77C2A5CF49FD" modified="2017-10-25" version="1">MRTEHSAARRGVAAAVGVASFLGGLATGYRLFARRWCLSWGATEEEVRRRMPGDDLLLLPDLLSTRAITIAADPAAVWPWLVQFGPQRGGIYSYDWIDRLLGIDVHSTRSILPQFQDLAVGDAVMVNSDSTPARVAVLEPERALVFRTDDSNWVWAFGLYPCPEGTRLVSRNRIATPGASPVLRLFDTFFLEPGSLVMEQKMLRGIKERAEAHRVADPVPIGSRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC5</accession>
    <name>A0A231HAC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetyl-hydrolase LipR</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lipR_1</name>
        <name evidence="3" type="ORF">B7C42_02064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45772">
        <property type="protein sequence ID" value="OXR45772"/>
        <property type="gene ID" value="B7C42_02064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="37196" checksum="087C433081C7B5D1" modified="2017-10-25" version="1">MTMCDLEPVGPVNHAKPSLRSRMLIAGMRMTHADKTFADPQALRESIRKSQRPDRDRPPAELHTHYWVTRRNMRGRPVYTIRPLEGGTSRHVLYLHGGAYVHQIQHDHWKFLARLVDRTGCAVTVPLYPLAPAHHGDDTVAMVRAVHDEVFAHTASENKVFMGDSAGAALALVLARQLGATGAVTPKEVVMISPWLDVTMTDPMARALDPCDPYLGVAGLAEAGRLYAGDLDRRDPMISPLNAPAATPGRLSLFIGTRDILLADARRFRARCVREGVDLGYFEYPGMFHAWHLSEVPEARHALRQLVRIVQRPAPRSDTGESMYAPAGDVSKRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAJ5</accession>
    <name>A0A231HAJ5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778180.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45756">
        <property type="protein sequence ID" value="OXR45756"/>
        <property type="gene ID" value="B7C42_02048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016796">
        <property type="entry name" value="UCP021774"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021774">
        <property type="entry name" value="UCP021774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="14220" checksum="060AADD5796415CC" modified="2017-10-25" version="1">MNLAISTTLHTDRFDDAVERTRAALAEQGFGVLTEIDMAATLKAKLGEDMEDYLILGACNPPLAHRAVGVDRRIGLLLPCNVIVRRDPGDAGAVIVEAMDPEVMVQVTGDPGLQPIATEAAAKLRDAIDALTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAS3</accession>
    <name>A0A231HAS3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate-pyruvate aminotransferase AlaA</fullName>
            <ecNumber evidence="2">2.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alaA</name>
        <name evidence="2" type="ORF">B7C42_02228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45935">
        <property type="protein sequence ID" value="OXR45935"/>
        <property type="gene ID" value="B7C42_02228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="44437" checksum="227C5C19EF59CF71" modified="2017-10-25" version="1">MFMQVNQSSKLMGVSYEIRGPVAEQAARLEAEGHHVVKLNTGNPLPFGFEAPAEILQDIVRTLPVSSGYSSSKGLLPARRAVVQYYQTLGVADIDVEDVFLGNGVSELIMMALTALLESGDEVLVPAPDFPLWTAATTLNGGRAVHYICDEGADWYPDPADIAAKITDRTRALVLINPNNPTGAVYPPEVLRPILDIARRHNLVVFADEIYDKIYYDGLTHTSIAALAPDLLCLTFSGLSKSYRCAGLRSGWLVVSGPTGHAENYLEGLTMLAGLRLCANVPGQQAIQAALGGHQSIYDLTLPGGRLREQRDRAWEALTAIPGITCVKPKGALYAFPRIDPRVYPIHDDEQFVLDLLLQEKLHIVQGTGFNWPTPDHFRITTLPHADELESIIERIGRFLSTYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBJ2</accession>
    <name>A0A231HBJ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperone protein HscA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hscA_2</name>
        <name evidence="5" type="ORF">B7C42_01147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46182">
        <property type="protein sequence ID" value="OXR46182"/>
        <property type="gene ID" value="B7C42_01147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="454" mass="47035" checksum="F301C45A3507C08B" modified="2017-10-25" version="1">MGAGAIRVAIPHPGNSAERFVATAFDVQAMPVGEQYSMDDVAAETVGAVFGSAPEIAATALAYRNEQHARTLRGALARRQLTNYELVPEVAAAREFLRATGELQGYRTVALYDLGSSGLSVSVIDVESGKVSHSERTSDISGDYLDSLIREQQIASGRIEHPPTAQGLAALDGVCRQAKEQLSSTTAVAVPSEHGLVLLSQENFEALIMLAVESSARMTRDVMMRSEQAVQAVFVIGGCARIPLIARILERWMGMPVLVPADPETVIVRGAALLARPAQVAAPAPVPQAPGPGSADDTVQLAPVWLSEDALRRARKRNKARATNSLGGKVGAVGAGRRRELSVAGVAVGALVVVAALGIGLGWGQSVLRGDSQSNTSASSSVPAAPPRASAAPSVAPTTDATNASVAAPTPNWQAPTTTTTPPPPGPPTIVVPGLPPIVVPTIPPLLPPFPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBS4</accession>
    <name>A0A231HBS4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46269">
        <property type="protein sequence ID" value="OXR46269"/>
        <property type="gene ID" value="B7C42_01235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5931" evidence="4">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="41902" checksum="160B29DCB6B3D45C" modified="2017-10-25" version="1">MRTKAESAGAAPPADSTAPGPTAATAPLWRAAQVFRLVTMLYAVGQQFASVSSYQRQPLSWVLIGILVLWSVVSALWLSRWSVTGWERRAVVIGDLAVAAGLMAATRLVADYPWYHGHQTVPTTLWVANAVMSAAIEWGALGGVAAGLAISVASVVVREQWELDLWSDATAPVLVSVGLAIGLAAATARRAQRQLEQAMRLTAATAERERLAREVHDGVLQVLAYISRRGSEIGGTTAELADRAREQEVALRVLISEQGRNGSTLGAREDLRSLLSAFAAPSISVSAPGEPVTIGGWTAREIAAAVGAALSNTALHAGVEAKAYVLLEDIGDTVVVSVRDDGPGIAPGRLPAAVAEGRMGVSHSIVGRIEALGGTAELLDTTDGTEWEFRIPRDGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC62</accession>
    <name>A0A231HC62_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB_3</name>
        <name evidence="6" type="ORF">B7C42_01404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781816.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46438">
        <property type="protein sequence ID" value="OXR46438"/>
        <property type="gene ID" value="B7C42_01404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="34883" checksum="7124A38BB5041E4D" modified="2017-10-25" version="1">MSTPVRDLIIVGSGPAGYTAAVYAARAELEPLLFEGTQFGGALMTTTEVENFPGFRDGIMGPDLMEEMREQAKRFGADIRTEDVEAIDLSGPIKSVTVGGEVYQAYAIILAMGSAARYLGVPGEQELLGRGVSACATCDGFFFKGQDIVVVGGGDSAMEEATFLTKFASSVTIVHRREEFRASRIMLERAKANEKIRFRLNSEVVQVHGDTAVTSLTLRDTKTGETSELAATGLFVAIGHDPRSELVRGQVDLDAEGYVKVREPGTATSVDGVFAAGDLVDHTYRQAITAAGTGCRSAIDAERWLAEKGDITSNTLDNAGNPVEVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCT6</accession>
    <name>A0A231HCT6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.303</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ncsB1</name>
        <name evidence="5" type="ORF">B7C42_01718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.303" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46741">
        <property type="protein sequence ID" value="OXR46741"/>
        <property type="gene ID" value="B7C42_01718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="112"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="35138" checksum="7606AC08455B1F06" modified="2017-10-25" version="1">MSSPERPASILALADLATPMAVRVAATLRLVDHAGAVGATAEELAARTGTSAPALRRLLDHLVTVGVFDRQVSGRYRPTSLGDQMSADSPDAFELLLLDIGCAGGRAELAFVDLLSTITTGRPAYSRRYGRDFWADLQAEPALRASFDAQMNCRFRIYADQIAHRFDWSRFSGILDVGGGDGTLLTAILRAHPGVRGCVLDLAPTAAAATERFAAAGVDDRATAVAGSFFDPLPTGADAYLLSDILHDWDDERAAAVLGECARAAGSYGAVVVIEPIRGRGAGTAIDLFMLMCFGGRERTVPELAELGARCGLALQSSGPVADGRTALEFRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD38</accession>
    <name>A0A231HD38_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46893">
        <property type="protein sequence ID" value="OXR46893"/>
        <property type="gene ID" value="B7C42_00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="431" mass="44139" checksum="EFB08B2CAD112DBC" modified="2017-10-25" version="1">MVVRPVVTLGASIARDCVDAVALRDGSAKLTDRVLAHHVAELGTAAPAGLPGLIESLLDGLAAEVGEECEIAGAAVTYRDAAGRRAVVTGLASGPWYEASLVSAKSAHLALARAMTWASEFDHLLICELMPGYQGFSLISPHRDRVVAATATAAGFVSEDSVRLGIAAAWDQLDAAGVRPSAVVAIGSAADHPGVAALLSAGFNAPVIPCAVAAAGSAIGAALVVQPEAFVADAGDRARVSRNSVAVVAAASVLAGGLTIGGVHELTDHPRSDATTRLADARNAQPSRGPRHARPEPGLPAVDSIPELPVDGTADQPSTGPRHAAPDPSTADPASAGWGPDGSPWLGVRGSDPASEPKRLAKEAPQPDAPEPQSKSVIPAPTEPVGAPNGSLLFPGESAPPQLGTTEFNEWWDNHWRLTLRWMVAMMPQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD77</accession>
    <name>A0A231HD77_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46667">
        <property type="protein sequence ID" value="OXR46667"/>
        <property type="gene ID" value="B7C42_01642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="34560" checksum="DAF7D1283105457F" modified="2017-10-25" version="1">MANNAFPPGWPSLSGDVLSINRFLKDPLWVLRALRTIGDQMFISKRVLTGQFYTESGSIAYEQNESIYADGTPRAIPPGGEYPVTTTGTGPASLANVIKWGQDTEFTWESISRQKYDVVRRGLLKLVNSHIQQIDSVALSAVASAVTQTAAAIAPWDGSGTTPQILRDLMRAYATIIDLKQGYMPDVVLLEPIVFANTVSDPSLMNLLPREVPGVSSAPVNGGWESPYMRKIGGFTFITSPNLPTLGRVTLLDSSVFGGFADERLNDPGYVGSTDEGADGIQVKTFPEDKTDSIRVRARRITTPLVLEPAAAVAITGVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDT9</accession>
    <name>A0A231HDT9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lcfB_1</name>
        <name evidence="2" type="ORF">B7C42_00108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46992">
        <property type="protein sequence ID" value="OXR46992"/>
        <property type="gene ID" value="B7C42_00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="25803" checksum="4B54A393E2D83182" modified="2017-10-25" version="1">MKAWSGPGPECGPRAKGVVLTHGNLWWHNIGVILALDIASDDVSLVCAPMFHIGALNVTTLATWIKGGRLVIHESFDPAAVLDDLQAERVTTMFGVPMMCETVSALPGFADADLSALRLIITGGAPVPIGLLRRFRDRGVELAQGYGLTEAAPVAAFLTAEHAERKLGSAGRAVLLCDLRIVDEAGTPVGPGVTGEIEVHGPTVTPGYLDAPETTALAFDGEWLRTGDGGHLDAEGFLFIADGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE88</accession>
    <name>A0A231HE88_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_00382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47260">
        <property type="protein sequence ID" value="OXR47260"/>
        <property type="gene ID" value="B7C42_00382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="421" mass="43775" checksum="BCA22182BC672BE9" modified="2017-10-25" version="1">MTAPAAVDFHPARVATAPRVWWGVAAAIFAIAWGGNEFTPLLVMYKNDGLPVTTVNLLLFEYVLGIVPALLIGGPLSDRYGRRRLMRPAPLITAVGSTLLAFGSGVVPMLSIGRVLCGVGLGLAMAVGSSWLKELSQPPFGPASATGTGARRSAMSLTGGFAIGAGVAGVLAQWAPWPATLAYLINVALCLIAAVWVLRAPETVAPQPVRKPLRDDLRVPAAGHRRFRRIALPLALWLFTSAAAAYAILPTLAADRVAGTPIAFSALITVITLGCGFAIQSVARRIDLPGTARIAALSLALTTAGMAASVYAAATLHLWAVIATAAVLGFGFGIGMVAGLQEIERIARPDDLAGLTAVFYSVSYLGFGSPALLSLLHNALHIGYPVMFAAGAVIALGCLAVVLNNYRDPDPACAVERRISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF57</accession>
    <name>A0A231HF57_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DSBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47317">
        <property type="protein sequence ID" value="OXR47317"/>
        <property type="gene ID" value="B7C42_00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="26946" checksum="81C51BA1F5563A6B" modified="2017-10-25" version="1">MRVEIWAEVTCPWCGLGSHRLDRAVQQFRLEHGTRIEVLHRSFPLSSAFPADRTIDVRAALLRQHGVSGAQAEVSTRRIEALAEAEGLSPYRVLDNRVGNTDLAHEFLAHATTEGCNRAAWNAIFRAYFGQARPVFALDDLLDLGEELGLDRAETRRALTERRHRPQVQDELARARRLGAAGAPFILVDGKFGVAGAHTSDSLLDTLRRAWDESHPAAVDDPAEGPCAGPTAALYPPITTDRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG72</accession>
    <name>A0A231HG72_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bicarbonate transport system permease protein CmpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cmpB_1</name>
        <name evidence="7" type="ORF">B7C42_00974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779645.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47849">
        <property type="protein sequence ID" value="OXR47849"/>
        <property type="gene ID" value="B7C42_00974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="29727" checksum="4BCDB31DD12E2936" modified="2017-10-25" version="1">MTAIVQSPAAPAGNANSKRTQGKSLAAAGRVTRTALLWVASGVLGLAVWSFLAWWYGPTTIASPVEVWSAAVELAQRGVLWTSISASAQRILLGWSLGVVIGAPIGILMGRVDLVRQLLDPYIEFFRFIPPIAFVTLAVVWFGIGETSKVVLIFYTSVFIVTVSTIAATVSIAENKLQAATNLGANRLQLMKTVVLPSAVPGIVTGARLAMGNSFLTIVSAEIVAADRGIGSMIWQARNYGRIDWTFVGIIVLGIMGFAFDRVLRVLSAKFLSRYGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSQ0</accession>
    <name>A0A231GSQ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000324">
        <property type="protein sequence ID" value="OXR39575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39575">
        <property type="protein sequence ID" value="OXR39575"/>
        <property type="gene ID" value="B7C42_08357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="45" mass="4903" checksum="2A51AA31B9EAE18F" modified="2017-10-25" version="1">MEFLLILLVIPVLVAIVLIRRKKASGSAEDPPQIMGNEGSRKADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSQ9</accession>
    <name>A0A231GSQ9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000133">
        <property type="protein sequence ID" value="OXR39618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39618">
        <property type="protein sequence ID" value="OXR39618"/>
        <property type="gene ID" value="B7C42_08314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7168" checksum="2205E0D5AD5699FA" modified="2017-10-25" version="1">MSVDLSGAHWFKSTHSSAGSDCVEIAHLDGGYVGVRDSKNPAGGALVFTPSEWDAFLAGAREGEFDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSU2</accession>
    <name>A0A231GSU2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000086">
        <property type="protein sequence ID" value="OXR39687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39687">
        <property type="protein sequence ID" value="OXR39687"/>
        <property type="gene ID" value="B7C42_08245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="110" mass="12244" checksum="FE3F5790548AB6B1" modified="2017-10-25" version="1">MAQPRITGPLVKVLDKLLDHPRESFYGYDLTKSTGIKSGTLYPLLVRLEEAGWLESGWEESQVEGRPRRRFYKLTTDGLQGAYDVLRSLPAPKVSTRAAEVLRPNLGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT51</accession>
    <name>A0A231GT51_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03572</name>
        <name evidence="2" type="ORF">B7C42_08170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000071">
        <property type="protein sequence ID" value="OXR39758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39758">
        <property type="protein sequence ID" value="OXR39758"/>
        <property type="gene ID" value="B7C42_08170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44016">
        <property type="protein sequence ID" value="OXR44016"/>
        <property type="gene ID" value="B7C42_03572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="7237" checksum="2A4683A6542F1FED" modified="2017-10-25" version="1">MTQAQLATTVGVSRQTVISIEQGDYAPSVYLALRIARALGTTVEDIFWTEDLEGTWPKPLHSKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT86</accession>
    <name>A0A231GT86_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000064">
        <property type="protein sequence ID" value="OXR39792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39792">
        <property type="protein sequence ID" value="OXR39792"/>
        <property type="gene ID" value="B7C42_08132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="36789" checksum="C83FCD46C2EBAF44" modified="2017-10-25" version="1">MDHPLRTADDGAVDLHGGESDGDRLLPLERSFRRIGEGRLRKVLEPFFVRFGDQAGDSQRPPCAPQHGCDFPAEPVACGVIDRVPEFMDDIVVVGPPAGRVEPDRAVVQIVLERLSSVGHPGQVQRQPRAPGAPIEGLGVDPGIRQEIDAQFANIAHVRDQIRGMPVSGELVVQRLENLSHRIDGDAGMVESGDDEVGVAEIELLDRAGFGLCVSAQSADVCGLLRGVRRMSFGAPELGHRLRVQVEQHVFLCAREVRQPILEVGNLFPHRGDLGARDAVALPHPAAVDIPDEFRGEWARHGLLGIESGPPAGHLAVRADIPMRCAAPSPGDRVQQTEQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTA1</accession>
    <name>A0A231GTA1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">adk_2</name>
        <name evidence="1" type="ORF">B7C42_08087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000058">
        <property type="protein sequence ID" value="OXR39846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39846">
        <property type="protein sequence ID" value="OXR39846"/>
        <property type="gene ID" value="B7C42_08087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="31487" checksum="068D476D876782D1" modified="2017-10-25" version="1">MLIVGSPCHPRSPWSNDAITRFPARICALCIPRIRRGRGAFRPEPRPLGPDTPGPIERGLAMPLSLVVPIFGPPAAGKTTLTLHLGLSPGRTIFRLREHVPKEVLAATATDSARLGWIDEFTVADTLRSYFATLQADAAVHTVLLDNFPGSGSQVGHLLATVWPLIPRVHIEPIEVVTDVRTLKQRARSRKVCHQCERDPIRDPRLPATPASEDTWTCARCGGLLHPRRGDSPRLFKARLQRYHQAAEGIRDGFTSSGLTITQLDTTNTIDSAANLLAPLLISRSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTH0</accession>
    <name>A0A231GTH0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39927">
        <property type="protein sequence ID" value="OXR39927"/>
        <property type="gene ID" value="B7C42_07990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="526" mass="58553" checksum="98562DC35B83EFA0" modified="2017-10-25" version="1">MRWGSVIELLAEGDLVVEKLADLTTVETRDSLAQRFRRTLGFSADELSDGTGFTFPARLAVAWSRRPDELDARLRRQLPHLLEPEQELTPEVRTHLTRLLASTHVLPAHQAAIASRKITLAALAADPDNCAEVVAELVNEESAHYATHRQVQQEIAAFNNATEAEDRMVPSCDLYQRVIEGDIRRIARRVLGLLGERHDRNVMLKTLEDRLTARTTEPGCALLLSCINRRWRNAIAHSQFHWDTVNQAVSLDGELALPAEIAYAALRAFEIAAGFNAGVELALNEADKQNYSQPEPNDILAWDMEINRRLGANGIEPISMRRFQRTIRISVKPLSIDNLRDHLIGILQTRYRIPEIDTWEIVQSNRPDIVLKNKALDAAEGLVETGVDGHSYIHPHSAELVLYAEAALNCGQPAQQVAKGVLSLSSANILGEYEIFQGRSSFDRVSIPEAMVSTISRQIRGIRKTATLLPRPARQKLIDHANILHEQRRALHDGGGKALPQSVKFACKVLAKGPAMFPWLDSDSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTX3</accession>
    <name>A0A231GTX3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside triphosphatase NudI</fullName>
            <ecNumber evidence="5">3.6.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nudI_2</name>
        <name evidence="5" type="ORF">B7C42_07994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782406.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39931">
        <property type="protein sequence ID" value="OXR39931"/>
        <property type="gene ID" value="B7C42_07994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="17004" checksum="5F08FFAC4956D873" modified="2017-10-25" version="1">MGRTDYYNDPEAPDANSIKVAVSAVVQDSAGRILMIHRTDNDKYSIPGGGLEIGESVADAVVREVKEETGIDVEVTKLVGVFSNPRHVIAFDDGEVRQEFSICFLAAPRGGQLRTSAESKEVKWVAPADLSELDIHPSVLLRIRRGLSSSSEPYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUF5</accession>
    <name>A0A231GUF5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40246">
        <property type="protein sequence ID" value="OXR40246"/>
        <property type="gene ID" value="B7C42_07671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="12162" checksum="FFE2B81ACEDECE61" modified="2017-10-25" version="1">MIKSGTEIVDLLMIARLTEQAAIADIYSCDLFYDTRDGRPTGRALLDWWGAEVWDDPTPTLEGLDETLESLGYVRTSDWRERVTASGVVRYFADGQVHLADCPIGPPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUJ4</accession>
    <name>A0A231GUJ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40299">
        <property type="protein sequence ID" value="OXR40299"/>
        <property type="gene ID" value="B7C42_07637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="191" mass="21512" checksum="69E67B946356757C" modified="2017-10-25" version="1">MTESQLVEVADIASVVSRCLSDLEPVFEQIDWAEDEIARAQRRHPRRRNTLYHSFGLLMPTHERMRQEFVYRSHCRELLDRVAAGLSPVPGTAAEVALAVMAASQRAPLNTAAFGLYARMWIQAGFPHLESVTDSHEHYEAIAKSRIDDLEAETRTRLSVADRVLRFIECPGRHHGQPASDCEYARSSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV33</accession>
    <name>A0A231GV33_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase PknE</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pknE_3</name>
        <name evidence="3" type="ORF">B7C42_07431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042940.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40493">
        <property type="protein sequence ID" value="OXR40493"/>
        <property type="gene ID" value="B7C42_07431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="55"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="24506" checksum="BDD3CD69BDCB1510" modified="2017-10-25" version="1">MSNRTTYALGAVALVVVAVIVVLVVRWNSDHGLTVQEDGYGAAHDPAVQALLDSDGAIVLGKTAAAKTIDMFEDPMCPSCGALEHYYGQQIAKAIDQGKLAVRYRFVNFLDPKSSSKDYSTRAVAASECVADAGDGPVFSKFHMALFTTKQPSEDGGNLTNEQLAAIAKDSGASAEVQSCIAKGDRVDSARNHAQSSLAALKDAVGQVQTPTVLDGGKNVDVENSDWVTKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV89</accession>
    <name>A0A231GV89_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40516">
        <property type="protein sequence ID" value="OXR40516"/>
        <property type="gene ID" value="B7C42_07455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="58" mass="6517" checksum="26728A0AA9B335CC" modified="2017-10-25" version="1">MIPLLIGVLVAAPAVYFGITHWPQRIPPERTVTAIKRRIDSERENHPGRRRLGGSCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVA0</accession>
    <name>A0A231GVA0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40401">
        <property type="protein sequence ID" value="OXR40401"/>
        <property type="gene ID" value="B7C42_07567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="58" mass="6014" checksum="7F07D8D304D8E241" modified="2017-10-25" version="1">MIGVAPESLCGPALDVVVEGLARRDVGSVGEDALADRGSQIAALIGVARLEDHRMSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC7</accession>
    <name>A0A231GVC7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine monooxygenase RutA</fullName>
            <ecNumber evidence="2">1.14.99.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rutA_6</name>
        <name evidence="2" type="ORF">B7C42_07388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.46" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40579">
        <property type="protein sequence ID" value="OXR40579"/>
        <property type="gene ID" value="B7C42_07388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="31231" checksum="C4EB848B0D6356F9" modified="2017-10-25" version="1">MRFGLHGLGIGSGSRPEIIDATARQAERRGFGTLWCGEHVVMVDESSSTYPYSDDGRIAVPATADWLDPFSCLTYAAAVTSTIHLATGVVLLPEHNPVIMAKQAASLDRLSAGRFRLGIGIGWSEEEFDALGIPFAGRAARTADYVHAIRTLWRDDPATYASDHVSFRTIRVNPKPTQTHLPILVGGNSDRALRRVAAWGDGWYGFNLDTVATVRDRLHLLTRFCTDTGRDIADLYLAVALRTPTRADVAELSALGVTELVLVDTPPESPDECVDWVDGLADRWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVE6</accession>
    <name>A0A231GVE6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="4">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_07385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40576">
        <property type="protein sequence ID" value="OXR40576"/>
        <property type="gene ID" value="B7C42_07385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="8">
        <location>
            <begin position="162"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="9">
        <location>
            <begin position="508"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="651" mass="68069" checksum="A2A4379D9CA38328" modified="2017-10-25" version="1">MDPTAKQRAALGLICDTFTPGDGLSLPSATELGSVATVFDILSRNPRPAESKQLATLLDLWDSRVAGLLLGNRGRRFSSLTADERERTLLRLGDSRIAVKRTLFQALKQAALLSYNVTPGPTGSHPLWKAIDYPGPPGTLAAAPAPALSVLRPTEPTTLTCDVVIVGSGAGGGTAAAVLAEAGLDVIVLERGNYYDDRDFGTGELDALLNLYAPGPPATSEGQITLVAGTCLGGGTVVNWSTSLRTPDEVRAEWAGLGATQFAQDEYTTALDAVTGRLGVNDRHSPLSARDSVLERGATALGWHIDTLPRNVGDACDAGVECGRCPYGCRVGAKQSVTKTWLADAAAHGARFVVDANVRRILVNNGRAEGVSAVGSNGTPIEVRARAVVVAAGAVQTPALLKRSGLRNKNIGNYLRLHPAAAVFGVFDEPIRPWEGGMQARISRQHRDLDGNGYGVIYETGPIHPGMGVGFMNWRGAAAYRANLLELNKSVALGVITRDRDHGSVGVDKNGEPVVSYRLSAHDRGHLHTGITGAAQILEAAGARRIYSGQQAGPAYEPGRTGSHAEFAAACAAAGYEPGQCAMGALHIMGSARMGGSPDMSAVDPDGATWDVNNIVVADASCFPTASGVNPMVSIEAIAYMNAKRLAARLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW88</accession>
    <name>A0A231GW88_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">snaA_2</name>
        <name evidence="4" type="ORF">B7C42_07019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783154.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40884">
        <property type="protein sequence ID" value="OXR40884"/>
        <property type="gene ID" value="B7C42_07019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="449" mass="49227" checksum="D684DEB0DEB3B5DA" modified="2017-10-25" version="1">MSERQLFLAGYVLFPGNHYVGAWRHPYSERDFNDRTLFEDVGRTLERAKFDMAFIPETLAFNPNFARYGLSNAIKHEPTQLAAVIAGVTRHLGIGVTLSASYDAPYHLARTLSSLDQFSGGRVAWNIIMSKGEATQANFPFVEELERAELYDRGDEVVESIVALWDSWAPNALVADVETGMFVDTDKVTTPDYRGKYVQVRGPLTLPRSPQGKPVLIQAGDSPRGRRFGGRWAELVFAIENNEADLRAKREDLRRLAAEAGRDPDSIKLIAAVQPIVGETTEIARARQRFLGELIDTDAAVAFLSQFVRTDLTGLDPGLQFTDAVAQRSTDAAAGVRLLDNLTALAAGNGETLGSELTLGEIARHFGASEFTPQLVGTGVEVADQMAHLFEVEAVDGYVLSPTHFPGAFDDVARAVVPHLQRRGIFRTDYADTTLRGNLLGRRYSPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWI3</accession>
    <name>A0A231GWI3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40851">
        <property type="protein sequence ID" value="OXR40851"/>
        <property type="gene ID" value="B7C42_07135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="10823" checksum="C2B3D98AF6771991" modified="2017-10-25" version="1">MSGKMYFNFEQVNEHHTTLKGLTQAMQDNILHLRALQEALADLLGGSTANAYQEVAGNLNRLMSDHQQNLTNLNLSINAAAGHGGTVQTADQVSARSMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWP4</accession>
    <name>A0A231GWP4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40921">
        <property type="protein sequence ID" value="OXR40921"/>
        <property type="gene ID" value="B7C42_07056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="92" mass="10054" checksum="B0BB1EF05609CF3B" modified="2017-10-25" version="1">MPFPPEITQRLRSTPEQMAAAWVGGSPPKGEPVVVVPYDPCWPRMFDEQADAIRRALAGRMITIEHVGSTAVPGLAAKPIIDEIYGRAFDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWV7</accession>
    <name>A0A231GWV7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_21</name>
        <name evidence="3" type="ORF">B7C42_06842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41072">
        <property type="protein sequence ID" value="OXR41072"/>
        <property type="gene ID" value="B7C42_06842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="410"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="497" mass="53183" checksum="FF8306FD9CA13CC3" modified="2017-10-25" version="1">MDVTNLAINLKDAAGQFPDRAAVRLDDQVLTYAAFDDVSARVAGRLRDLGAQPGDRVAMMLPNVTAFPIVYYGILRAGLIAVPMNPLLKEREVRHHLADSGARILFAWHTAVPEATAGAARTQVRVLTVTDDSATEFASWPDSPEVTVRDDEDTAVLLYTSGTTGTPKGAQLTHANLRANAAVAARTLLTATPDDVIMGCLPLFHAFGQTCCLNVAVLSGATITLAPRFDPELVLKLIERDGVTIFEGVPTMYVAMLGAGPGIADTGTLRLCLSGGAALPVEILRGFEERFGVPVLEGYGLSETSPVASFNRVGAARPGSIGTPIEGVRMRVVDADGNDVAPGDAGEIAIRGHNVMSGYWDRPTATAEAIRDGWFHTGDMAKQDEDGYFYILDRKKDLIIRGGFNVYPREIEEVLYEHPAVLEAAVLGVPHSTHGEEVAAVVALAPGPEATADELRDYVKARVAAYKYPRQVWLVDALPKGPTGKILKREIVVPQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX53</accession>
    <name>A0A231GX53_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782447.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41187">
        <property type="protein sequence ID" value="OXR41187"/>
        <property type="gene ID" value="B7C42_06783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="13132" checksum="6BFDBE6B0A0571C8" modified="2017-10-25" version="1">MSDYDDYDEDDLAPPAPDWQNRVYEVFNPDHTVGVACDRDGEVVGLHLTDDARENGDTWLAAEILRLARLAHTKSRVGLRSEMEYNGTRPYTIDSFDLPTESSYRAMEIAEFGTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX87</accession>
    <name>A0A231GX87_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41216">
        <property type="protein sequence ID" value="OXR41216"/>
        <property type="gene ID" value="B7C42_06614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="9039" checksum="5AE90560C2A8C408" modified="2017-10-25" version="1">MNQMETELLEFAVAWAPYGGNDDEAFVRFGLSSVQFHARLLRLLHGPAAHVLTHATRAALHRQCSDRLRHVRYENDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXG6</accession>
    <name>A0A231GXG6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="6">DHNA-CoA synthase</shortName>
            <ecNumber evidence="6">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">menB_4</name>
        <name evidence="6" type="synonym">menB</name>
        <name evidence="7" type="ORF">B7C42_06708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="function">
        <text evidence="2">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41310">
        <property type="protein sequence ID" value="OXR41310"/>
        <property type="gene ID" value="B7C42_06708"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="76"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="280" mass="30598" checksum="9A2649556C52C283" modified="2017-10-25" version="1">MGDSTGEWSTVRRYEDVDYSRTADGVAKITICRPEVHNAFRPQTLVEISDALTHAREDPSIGVIVLTGEGDKAFCSGGDQRVRGDTGYLTDPENPGAVGRFHVTDLQVQIRRLPKPVVAMVAGYAVGGGHVLQIVCDLTIAADNARLGQVGPKVGSFDGGFGAGLLADMVGVRKAKEIWFLCRQYDAAQALEMGLVNTVVPLADLESETLAWCRRMMEMSPMALRLMKASFHAAEDGLAGIQQLAHDTNLLFYATEEAKEGREAFKAKRRPEFERFPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXY7</accession>
    <name>A0A231GXY7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlD</name>
        <name evidence="4" type="ORF">B7C42_06578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780340.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41435">
        <property type="protein sequence ID" value="OXR41435"/>
        <property type="gene ID" value="B7C42_06578"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="8"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="30098" checksum="1D31C313D18B2175" modified="2017-10-25" version="1">MSPDSQSRLVVTGAGGQLGRALRTEAPAALALGRADLDITDAEAVRAVVRPGDVVLNCAAYTAVDAAESEHDAAYAGNVTGPAVLAAACRVAGARLIHISTDYVFDGTASDPYEPDHPTGPASVYGRTKLAGEQAVLGEYPQATIVRTAWVYTGDRGDFVATMRRLEAERETISVVDDQIGSPTYAPDLARGLLELVARQPIPGVLHASNAGAVSRFGLARAVFAELGADPERVRPCGTADFPSPARRPAYSVLSNRAWAQAGLTPLREWRAALADALARLSDRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY69</accession>
    <name>A0A231GY69_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_06363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41471">
        <property type="protein sequence ID" value="OXR41471"/>
        <property type="gene ID" value="B7C42_06363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="48"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="17189" checksum="8EBDDA73003F0416" modified="2017-10-25" version="1">MNSGALATVGARNAVWDGIELPPMLHSQWYDRGRRFLGGDHAFAQLIRFALVGGASNIAYALLFVVMIGVGPLVANIAGSLVSTAIANELHRRLTFRAAGRVGWFTAQWEGGGLALLGVVISTAALAGLRFWAPGLGDLAQASAVLAVTGGVGGLRFLALRGFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYA8</accession>
    <name>A0A231GYA8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41604">
        <property type="protein sequence ID" value="OXR41604"/>
        <property type="gene ID" value="B7C42_06245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="61" mass="7146" checksum="BA2CC2FBA19B72BF" modified="2017-10-25" version="1">MSRGGVGRVADDRIGVAIVRHHLERDGEKLSYVLAQVYRVDNAKLVEYWEYPEPAFYHAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYD9</accession>
    <name>A0A231GYD9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aerobic cobaltochelatase subunit CobN</fullName>
            <ecNumber evidence="1">6.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobN</name>
        <name evidence="1" type="ORF">B7C42_06268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778322.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41627">
        <property type="protein sequence ID" value="OXR41627"/>
        <property type="gene ID" value="B7C42_06268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1207" mass="131160" checksum="AC2C391FEF8657B9" modified="2017-10-25" version="1">MILLLSTSDTDLLSARASGADYRLANPARLLVEDLPGLLAGADLIVVRILGGRRAWEDGLDALRASGIPLVALGGEMAPDAELMECSTVPGGVAADAHNYLAAGGPGNLRQLHNFLSDTVLLTGHGFEPPVQLPSWGELDRTPEALSGNDSRLAAAPTVAVLYYRAQHLAGNTAYVEALCRALEQAGARPLPLYCASLRNAEPDLLETLRRADALVVTVLAAGGTKPATAAAGGDDEAWDIGALADLDVPILQGLCLTSGRDQWADNDDGLSPLDVATQVAVPEFDGRIITVPFSFKEFDADGLSTYVPDPERAARVAGIAVRHARLRHLPVAQRRIALMLSAYPTKHARIGNAVGLDTPASAIRLLTEMRTAGYDLGAAGEVPGLEERDGDALIHALIAAGGQDQDWLSAEQLEGNPIRIGARQYSAWFATLPEELRTAVVEAWGPPPGELFVDRSADPDGEIVIAALRFGNIVLLVQPPRGFGENPVAIYHDPDLPPSHHYLAVYRWLSAAADEGGFGADAMVHLGKHGNLEWLPGKTLGMSAACGTDAALGDLPLIYPFLVNDPGEGTQAKRRAHATLVDHLIPPMARAETYGDIARLEQLLDEHANISALDPAKLPAIRQQIWTLMRAAKMDHDLGLEERPDEDTFDDMLLHVDGWLCEIKDVQIRDGLHILGQAPAGEGELDLVLAMLRARQLWGGEVAVPGLREALGLDESGEESRERVDVVEQRARQLLAALQAAEWSPDAVGELVARYEPDAPDTLAAVLRFAATEVVPRLRQTGVEIERILHALNGGFIPAGPSGSPLRGLINVLPTGRNFYSVDPKAVPSRLAWETGQAMADSLLERYRADHGDYPRSVGLSVWGTSAMRTAGDDIAEVFALLGVRPVWDEASRRVTRLEVIDLAELGRPRIDVTVRISGFFRDAFPHVLALLDDAVRLVADLDEPAESNYVRAHTDSDLAEHGDRRRATTRIFGSKPGTYGAGLLQLIDSKSWRTDDDLAQVYTTWGGYAYGRDLDGAPAADDMRAAYRRIAVAAKNTDTREHDIADSDDYFQYHGGMVAAVRALTGKNPEAYIGDSTRPDAVRTRTLSEETTRVFRSRVVNPRWLEAMRRHGYKGAFEMAATVDYLFGYDATTNVVADWMYEKLSESYVFDDVNRKFMTESNPWALHGIAERLLEAAERKLWEAPQPETLDRLRQIYLETEGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYG2</accession>
    <name>A0A231GYG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type dhaKLM operon transcriptional activator DhaS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dhaS</name>
        <name evidence="6" type="ORF">B7C42_06277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41636">
        <property type="protein sequence ID" value="OXR41636"/>
        <property type="gene ID" value="B7C42_06277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="243" mass="26146" checksum="B56B0185C247C0CD" modified="2017-10-25" version="1">MWHGLKRARNAQPAAGCGTDGVLSARVPPSALRDRKRERTRRSLLKAAADLFESRGYEATTVADIAATAEVGTRTFFNYFESKEELLFPEPDERVTAAVAAIASRRSDERPVEVLLRALRAAGDNPGDHLGDDLAARIAVLRAQVSRTVPAVSGRAAHAQLAAQQEIARRLRDAFPDELDEVGAAALVGAVVGAVSGALTVLFSGRHAIEDGERLHRTIRETTSRVLAPWLSAGRHLTAEARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYH7</accession>
    <name>A0A231GYH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloprotease TldD</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tldD</name>
        <name evidence="4" type="ORF">B7C42_06276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41635">
        <property type="protein sequence ID" value="OXR41635"/>
        <property type="gene ID" value="B7C42_06276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="507" mass="54830" checksum="BF6E992C15634E2B" modified="2017-10-25" version="1">MSIASATVDEQFRALPLAALTDAALTAARAAGAEHADLRVHRLVTQSIRLRDGRVESVDNAVDLGFAVRVIVDGTWGFASHCELTPATAMAVAQRAVTVAATVRALNRERVELAGEPVYRDATWVSPYDVDPFTVPTPEKVALLQDYSQRLSSAAGIDHVTASVLQVKEQTYYADTAGSTITQQRVRLHPQLEAITVDAATGGFETMRTLAAPAGRGWEYVTGADGVWDWDDELARMPQWLAEKVAAPSVTPGPTDLVIDPTNLWLTIHESIGHATEYDRAIGYESAYAGTSFATPDKLGTLRYGTPIMHVTGDRTQEHGLATVGYDDEGVAGQRWDLVRDGTLVGYQLDRVFAPRLGVPRSNGCSYADSAHHVPIQRMANVSLQPDPQTDTSTAELISRVEDGIYIVGDRSWSIDMQRYNFQFTGQRFFRIRNGEPAGQVRDVAYQATTTDFWGAMEAVGGPSTWVLGGAFNCGKAQPGQVAAVSHGCPSVLVRGVNILNTRQEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYI5</accession>
    <name>A0A231GYI5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsbV</name>
        <name evidence="4" type="ORF">B7C42_06307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41666">
        <property type="protein sequence ID" value="OXR41666"/>
        <property type="gene ID" value="B7C42_06307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="119" mass="12364" checksum="3D1A66A33FEF3F04" modified="2017-10-25" version="1">MGYEGHSGCTADVIAVGGFVVVAAAGEVDSHTAPRLDAAVQQAVTRQPEQLIVDLSAVEFFDSSGMNVLVRALRQAGRVLVVAARPVRRVVEVTGLSTVFTLFDDIDAAVADAATHTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ8</accession>
    <name>A0A231GYJ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41655">
        <property type="protein sequence ID" value="OXR41655"/>
        <property type="gene ID" value="B7C42_06296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="20409" checksum="943856BEF1B42D51" modified="2017-10-25" version="1">MFSLPHAGRSAFASGDRSPARPPRTTPGPTRRRRSAALLITATASIPLLLAGCSSGGTSTAADANSVTVSDQWIKAADAGMSAAFANITNTSDHEIRVVDATSPASARMEIHEVVESNGASMMRPKAGGLVIPAHGSAKLTPGGDHLMFIDLKAPLRTGAQTPVTVKFADGTSTTFTAQVRDFAGNQENYSPAPAAHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYU9</accession>
    <name>A0A231GYU9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41770">
        <property type="protein sequence ID" value="OXR41770"/>
        <property type="gene ID" value="B7C42_06112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="161"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="24513" checksum="C32E34E3CAD7DEF4" modified="2017-10-25" version="1">MEIAGQRDKGRWRAELLAARAAVPPETRAAEAEALSLSVSRVLDIVRPPTDGPHTGHRRPAGGSGPKAPGSRWVAGYIPVAGEPGSVAMLDALRVAGARVMVPVTGPPGPLGWAEYTGIEGLRRARYGLLEPDGPPLGVAAIEWPEVIVIPALAVDRRGVRLGRGAGYYDRTLPAARPDARLVAVVRDTELLDALPEEPHDRRMGWALLPEAGLCRLDAGDREIGGRYSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYX5</accession>
    <name>A0A231GYX5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780754.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41809">
        <property type="protein sequence ID" value="OXR41809"/>
        <property type="gene ID" value="B7C42_06151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011242094" evidence="1">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="14359" checksum="F8931DDC422C6191" modified="2017-10-25" version="1">MNVRRAAAGAALAAATLSAVPAAASADNPEDPANGIIPAGAYHITQHPDNMIGSPVHNCDLQAFADSTTVTLVCGNSSRTGRQNAAGPDETYVTFEGVPVGLDLREIDARQGYWEGTLNAAGTSIDVPYPIAGITLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ64</accession>
    <name>A0A231GZ64_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenoxybenzoate dioxygenase subunit beta</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pobB_3</name>
        <name evidence="7" type="ORF">B7C42_05893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41909">
        <property type="protein sequence ID" value="OXR41909"/>
        <property type="gene ID" value="B7C42_05893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="232"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="317" mass="33538" checksum="7A41DBDCE9E51210" modified="2017-10-25" version="1">MREDRVPRRMRVIGKEVAAVGVVAVTLADPDGGPVPAWEPGAHIDLVLGDMTRQYSLCGDPSDRESLTVAVLLEPEGRGGSAYVHDKLEVGDVITIAGPRNAFGLSEAASYLFIAGGIGITPLLPMLRSVDARGVPWRLLYGGRTRTSMAFADDLAAAHPDRVDVRPQDECGLLDLDTALDGLGLGGAVYCCGPEPLLRAVETACGARDHLTLHVERFAPKAADPNAASDSFEVELARTGAVVTVGADESVLAALERSGVDAEFSCREGTCGTCEVAVLRGRPDHRDSVLTEDEQAADDAMMICVSRSHTPRLVIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZD7</accession>
    <name>A0A231GZD7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_05919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41935">
        <property type="protein sequence ID" value="OXR41935"/>
        <property type="gene ID" value="B7C42_05919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="21248" checksum="E081A88FAD21672C" modified="2017-10-25" version="1">MDSSGLPLLNDASAPTERADAARNRAKVLAAAAALFAGRDPRTVTMDDIAKAAGVGRGTLYRRYPDVGSIAVALLDEHERALQERLLRGEPPLGPGAPPGERLAAFYAAMVELLDTHAHLVLGAETGGARFRTGAYQFWAMHVRALLTEAGVAEPDSLVDALLAPLAAEVYRHQRERGLGSEQIAAGLAKLAHGVLEVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZH8</accession>
    <name>A0A231GZH8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41975">
        <property type="protein sequence ID" value="OXR41975"/>
        <property type="gene ID" value="B7C42_05959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="DUF4242"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="DUF4242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="173" mass="18421" checksum="8FD79EFA643A3D85" modified="2017-10-25" version="1">MSLYLYELVPTGEPGRTIGEFGAHADKAGGELIEAQVTAGAGRIFAIAEFAGCAAPALAADQVFAAAIDGPHQVRLVGADLATVKAARPAAGYLVEWDIPAEIDMETYLARKKANAPKYADVPEVSFLRTYVREDTAKCLCFYDAPDEAAVRRARAAVSTPVDRLHTLADPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZP0</accession>
    <name>A0A231GZP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maleylacetate reductase</fullName>
            <ecNumber evidence="4">1.3.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfdF</name>
        <name evidence="4" type="ORF">B7C42_05678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.32" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782826.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42079">
        <property type="protein sequence ID" value="OXR42079"/>
        <property type="gene ID" value="B7C42_05678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="10"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="356" mass="36716" checksum="0CE1BCF9820B12DB" modified="2017-10-25" version="1">MTMFTYDALPGRVVFGAGAARTGLLDEVDRLGAQAILLIASSSEYELAARLCERFADRLSATFSGVRPHVPVEVAERAREAAAGSDLVLSVGGGSTTGTAKAVALSTGLPIVAVPTTYAGSEVTPVWGMTDQGRKTTGTDRRVLPRTVVYDPELTLSLPAELSAASGLNAMAHCVEAFWAPRRNPVSSAVAEDGIRHLSRGLETVTATPDDLTARTELLLGAYLAGSAFAVAGSGLHHKICHVLGGAFDLPHAQTHAIVLPYVLAYNAPNASVATDRIGAALRQPDPIAALRQLSEKLGVPTGLRDLGVSEADLDAVVDDILAIAPGDNPTPVTAAGVRAILHAAWAGSDPIGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0G5</accession>
    <name>A0A231H0G5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42327">
        <property type="protein sequence ID" value="OXR42327"/>
        <property type="gene ID" value="B7C42_05526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="213" mass="22881" checksum="AF4439D4C78FEC35" modified="2017-10-25" version="1">MKGGTSIAVGVGIGYLLGRTRKMRFALGVAGAMMAKRSSDIPGELLERGTSLLKSSADLTQLTDTVRDELLGAARSAAVTAASNQLDSLNTRLQHGSSLLTGDLLSGNDRDRASDAEVEDAEFEDEDEAVRDAGEASPDDEPEDVDSGEEEEDRKPPAPRARKPAAKRARKTTSGTTARKSTERKSTERKPVSVSRRRSGSDSDEPPVRRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0H3</accession>
    <name>A0A231H0H3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42349">
        <property type="protein sequence ID" value="OXR42349"/>
        <property type="gene ID" value="B7C42_05548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="10079" checksum="41C39EC526DC2A39" modified="2017-10-25" version="1">MSMVLAVHDMYTTVLAQVGNPTPETPPAADKLLKLVRYFTWFVLLSGVTAITYGGGRFAWEKWSGGGLESPKMVAGAMIGGGVATSAGTIMNAVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0M4</accession>
    <name>A0A231H0M4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_20</name>
        <name evidence="5" type="ORF">B7C42_05631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42430">
        <property type="protein sequence ID" value="OXR42430"/>
        <property type="gene ID" value="B7C42_05631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="23627" checksum="790F7BEA6ABF07E9" modified="2017-10-25" version="1">MDADFAERHRSVRAHALGTPRGRLIGAMVECVGARGFSTVTLTDIVGRAHVSRSTFYEHFGNKEHCFIEAVHTGVEIIRTRIAEELAHLPAEVDPRQRLATMISTFCSVVAAEPDFARLILVESLLVGDATAEFRDQAVDHFATLYRNFHDQARAVDPGIPALPDEVIALIPDAIGERTRRVLVREGAHRVPDMAPTFIEFANTVLGLAPVVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1A4</accession>
    <name>A0A231H1A4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trehalose monomycolate exporter MmpL3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mmpL3_5</name>
        <name evidence="8" type="ORF">B7C42_05401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42623">
        <property type="protein sequence ID" value="OXR42623"/>
        <property type="gene ID" value="B7C42_05401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="50"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="488"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="697" mass="73944" checksum="7390BF89F775AF8D" modified="2017-10-25" version="1">MLEGFLLRWGRFVHRHRYPVFAVFVLIVAVSGFYGRDLGSRLTQGGWFDEHSESVVASKLADQTFGRDTDADVIVLYTAPPGHTVDDPPIRAAIGSALKDLHGRYPDRIKKIDSYFDGSMMGQFADASRTHAFASIGLHGSDTATVDNYLAIQKDLGAGGSGRGPGGTTVQLAGLQPVVEGINIGMQDDIHRAELIALPVVAVLLYFVFGGVVGALLPVLIGGMTILGSQGMMRLLTDHIDVNVFASAVVTLVSLGLAIDYGLFAVTRFREELAAGRSVEEATARTVATAGRTVLFSAAIIAVSLAALFIYPNGVLRSVPYGGISSVLLAALLSVTALPAALSIVGRRIDLWGWHRFAGIRSAQEIDNGFFSKLALFAMRHPARVIVPVVAGLLFLLIPFRHIEFGGLSERYLAADNPARVAQEKFDTLFPEFRTEPVKLVVVGADPQQLSDIRFQANFAPGLTGPFEAAAPTTNGINVLSTGLVHKSDADAAIAALRAIPHPPDVQVMVAGVPALERDAIHGLIDGLPLLATILATAALVLMYIAFRSIVLALKAVLMSALSLGAALGILTWIFVEGHGAGLLGFTPGPLMFAVLVLIVTVLFGLSTDYEVFLQSRMAEARAEGAPPAEAIRYGIAHTGGVITSAAAILIVVTGAFGFSDLVLMKYIAYGMIAALILDATVIRMLLTPAVLKLVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1N2</accession>
    <name>A0A231H1N2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] synthase 1</fullName>
            <ecNumber evidence="5">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kasA_3</name>
        <name evidence="5" type="ORF">B7C42_05088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776870.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42751">
        <property type="protein sequence ID" value="OXR42751"/>
        <property type="gene ID" value="B7C42_05088"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="12"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="414" mass="43021" checksum="4EB5F9244F7039BA" modified="2017-10-25" version="1">MTVSSRMRYRDVVVTSLAATTSIAGDVDSTWKGLLNGESGIDVLDDGFIDQFELPVRIGGHLKVVPSTVLSREETRRLSYVEQMALVLGREVWRNAGAPEVDPERLGVSIGTGLGGAEALIDVKDKMANGGYRRVSPLAVQMIMPNGAAAVVGLELGAKAGIATPVSACSSGSEAIANAWKMIVMGDADVVVTGGVEGSIQAVPIAAFTMMRAMSTRNDDPKRASRPFDTDRDGFVFGEAGAMMVLESEEHARARGATVHARLLGAGLTSDGFHLVAPDPDGKGAARAIARALQTAGLSKTDVTHVNAHATATPIGDTAEARAIAAAVGSHASVYAPKSALGHSIGAVGALESVLTVLSIRDGLVPPTLNLDNQDPDVDLDIVKGQARPGRIDYAVNNSFGFGGHNVSLTFGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Y4</accession>
    <name>A0A231H1Y4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adhT_2</name>
        <name evidence="4" type="ORF">B7C42_05180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42842">
        <property type="protein sequence ID" value="OXR42842"/>
        <property type="gene ID" value="B7C42_05180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="35439" checksum="1A4A70E169046377" modified="2017-10-25" version="1">MRALQLTGPGTLELREVPIPEIGPTDLLLKVGAAGICHSDSFVLGLPFPLREDPLTMGHEIAGTIEAVGTEVDGRRAGERGLVYLCWSCGVCRECVSGNENVCLAAGRTAMPPCPGLGPDGGMAEYVRIPANSFVPIGELEFATAAPLADAALTPYHAIRGAADRLRPGATAVAIGIGGLGHVAVQILKATTACRIIAVDISAEKLELATACGADLTLPADEKTAARILDLTDGRGAEAVFDFVGNDATAKLAVESVAPNGAYRMVGLDGGIPGIDAGPAGGPGLPWGASVRKSYGGTRSDLYASVALAQRGAIGVSVERFDLAEGPAAFERLDRGLIRGRAVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H248</accession>
    <name>A0A231H248_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PrcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prcA2</name>
        <name evidence="2" type="synonym">prcA</name>
        <name evidence="5" type="ORF">B7C42_04809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778356.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42923">
        <property type="protein sequence ID" value="OXR42923"/>
        <property type="gene ID" value="B7C42_04809"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_B">
        <property type="entry name" value="Proteasome_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="28453" checksum="CE8FD2AE0E1ED4CB" modified="2017-10-25" version="1">MTLPYYASAEQIMRDKTELARKGIARGRSVVVLVYDKGVLFVAENPSATLHKVSELYDRIGFAAVGKYNEFESLRRGGILQADLRGYQYDRRDVTGRALANMYASTLGTIFTDQLKPYEVEICIGEVGYPEQESNSVLYRINFDGSIVDERDFVVMGGNTDPISTALKDTFQPGLELRAAIRTAVDALQKGSPDNSDKDKRGIAVSSLEVATLEQARPRRAFRRIPHASLETLLSADGAANAGEENAEPETPSAGDPSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H271</accession>
    <name>A0A231H271_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mycofactocin biosynthesis transcriptional regulator MftR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mftR_4</name>
        <name evidence="5" type="ORF">B7C42_04818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778368.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42932">
        <property type="protein sequence ID" value="OXR42932"/>
        <property type="gene ID" value="B7C42_04818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="22033" checksum="990942EED8F415BA" modified="2017-10-25" version="1">MTTEPPPGLRERKKLDTRRALSDAALELMFERGLDHVLREDIAARAGVSVRTFTNYFANKYEALAYRQIDRIRRGIDLLRARPAGEPLWTAITEAMLEPLRVDGLDADPPPRDRLAEVRKLVASPEAQAALTRTSSDALTEAVAERTGTDPGTLYPRLVAEAVLGALVAAIEVYPRCAPPASITALTRQALELVAAGLPEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2N9</accession>
    <name>A0A231H2N9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione-regulated potassium-efflux system ancillary protein KefF</fullName>
            <ecNumber evidence="2">1.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kefF_1</name>
        <name evidence="2" type="ORF">B7C42_04964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43078">
        <property type="protein sequence ID" value="OXR43078"/>
        <property type="gene ID" value="B7C42_04964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="27549" checksum="63743EFFCBD6EBDF" modified="2017-10-25" version="1">MRILIVYAHPEPDSLTGALKDVAVHHLRESGHDVVVSDLYAMGWKAQADAADFGETGAGTFMQASGEAYSNGTLTADITAEQDKLRWAEVVLMHFPLWWYSMPAILKGWVDRVFTNGFAYGSGSTALPRYGAGALSGRRAMLVVSIGGREPAYSERGINGHIDDLLFPIHHGILYYPGMDVLPPFLVHGTIRVDSDRFADIAADLRERLSRIDTIEPIPYRTQAGGDYDRSLRLRDGLGHHTTGFGLHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Q8</accession>
    <name>A0A231H2Q8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43135">
        <property type="protein sequence ID" value="OXR43135"/>
        <property type="gene ID" value="B7C42_04557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23140" checksum="1B534F0BB90C9BFB" modified="2017-10-25" version="1">MSTVDISTGEAPEITEPDDELPPDTRRRPKAFARVATRVAIALLAVVVVAGCAVGGWSMIRHHTSVRDAARDAQLLDFSKDAVAQLVSTDSADPRGYVDRVLANSTGQWHDEFDARKRSVIDTMQASGGVTRGHGVAAGIERRNDDGSVSVLVVVTSQTSVPLPQPGPGQGGPAAPAPGSPTSPGPPSGVRVDTAPKQYQVRVDVTRVGGKFKLSKVGFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Y4</accession>
    <name>A0A231H2Y4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009730.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43187">
        <property type="protein sequence ID" value="OXR43187"/>
        <property type="gene ID" value="B7C42_04609"/>
    </dbReference>
    <dbReference type="GeneID" id="66723507"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="11846" checksum="8013C8859272ED29" modified="2017-10-25" version="1">MTETTAIERYFAAWNAGDADAIMATLDTDVVLEDVPSGHVARGPREARAFVAGALEKAPGASYDVVSSHISGDAFVVEWIMQPIGLRGASVGSLRGGRIGTNRDYWNAGPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H329</accession>
    <name>A0A231H329_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator TfdS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tfdS</name>
        <name evidence="3" type="ORF">B7C42_04692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43270">
        <property type="protein sequence ID" value="OXR43270"/>
        <property type="gene ID" value="B7C42_04692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="33813" checksum="1A19DBCED6E2C430" modified="2017-10-25" version="1">MAQSVSIDFTRLKYFVAVAEELHFKRAADRLHITPPPLSKQIKLLERELGGELFARSYHDVRLTPLGAALVEPAHRILDMVTELRATASKIAGSAGPLRVGATAFAPSDFLYAFEDAVNQLTAAPTQFSIPGSAAEVAAHLVAGHLDLGLIHLPCPESRVDFRVISRYRSGIAVRNDDPLAARAVITIDDLRDREVAVDIARANPLAMATLTRRLNSSGVARVVEAAGSRASEVELAAQVRSRRLVLLIAYAPDSILGRVFSPPQFKLIPIDDQRWKPGQLALAWSRDRPEQHPALRAAIDELTETFDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3C3</accession>
    <name>A0A231H3C3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43370">
        <property type="protein sequence ID" value="OXR43370"/>
        <property type="gene ID" value="B7C42_04237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="21219" checksum="27E808C874352FCD" modified="2017-10-25" version="1">MSPRAGLSRERIARAAAELADEVGFAHVTLSAVARRFGVKDPSLYTHVRNLRDLQVQVGLLAGAQMNERIGAAVAGRSGRDALFAFADAYRSYALDHPGRYAATQIRLDPDEVAGEPALLRGIELTAALLRGYGLSEPAFTDAGRLLRSTVHGFATLEAAGGFAHSRPAEASWHHILDALHRTLTQWPTPTEEKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3D8</accession>
    <name>A0A231H3D8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclohex-1-ene-1-carbonyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_04760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.10" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43337">
        <property type="protein sequence ID" value="OXR43337"/>
        <property type="gene ID" value="B7C42_04760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="410"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="627"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="765" mass="80582" checksum="02914FE45E313204" modified="2017-10-25" version="1">MEGSTGAAKVPAATGDWRARLTALLDDYVRRPRPETSRERAAAARAWQSEMVDAGVAAPGWPKSVGGLELGLEDQLDYYRMTSSAGVPKHPNPIAFIVAPTLIVYGSDAQKKRFLEPLLRADETWCQGFSEPGAGSDLASLSTKAVRHGDTYRVTGQKIWTTQATEADWMFTLVRTGPAGRGTDGISYLLIPMNSPGIDVRPLRDASGGYHFAEVFFDDVVVPAENLVGEEGEGWSVMRTSLGHERATAFLADEFRYRGLVDKVFSLAISQGYADDALIRQELAFVETGVRAIAANSARALDAVLRQADPGGVASVNRLVKSEFEQQLHRLALRLTGSGAALGGRSPGAVAGGSWTYGYFMTRASTIGAGTAEIQRNAIAEQVLGLPSHRGEGTRPAAVVPGRPLSPPDEDEAALREVLGKALAAHTGTDQLLTWATKTADYDIGLWDELIRFGLPGLALPEALGGGGASLRLLAAAVEEAGYAVAPVPLVPTLIALEVLRQVGATDAVRAICDGATAAFVVPVDDHGWAVEGGLPVLDGARLSGSVERVSGAPVADRLVLLARDSGTGELVLGTVKPIEVEIEPQESVDVTGTIGLVVLDGVEPEVIARGADVTRILDAARPVAQLVLAADSVGVANRALALAVDWAGQREQFGHLIGSYQAISHRCADMLVRAEGARAQVLSAADVESNDAETRLSVDVATAAALDAAVWTAENCIQIHGGIGFTWEHPAHLLLRRATANQVALGRPENLRDRAAGAVLARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4H9</accession>
    <name>A0A231H4H9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase PknE</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pknE_2</name>
        <name evidence="4" type="ORF">B7C42_03965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781232.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43730">
        <property type="protein sequence ID" value="OXR43730"/>
        <property type="gene ID" value="B7C42_03965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="82"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="27370" checksum="2EB8386619662215" modified="2017-10-25" version="1">MVNSEVSKNPRGKNSLTAVRGGDRTRTILIQVGVAAVLIALIAAIGISIAVKQSNKNDTGPVPSVAAQPAAPDAVTGSITDKGEIKIGKPGAKVDIRVVADLQCPACKMFESANAKAIEDAVNAGTASVRYNIIAFLDQSSGGTRYSSRAANAAYCVAGSDPTKFLPWLSTMYEQQPPEGGTGLPDEKLVQIAQAAGYTDPAVAECITSDKYDKYVQKTTKDVLNSGIKSTPTVYVDGKQITSSQQLMQPDGLRPVIEAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H554</accession>
    <name>A0A231H554_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase StkP</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">stkP</name>
        <name evidence="4" type="ORF">B7C42_03557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44001">
        <property type="protein sequence ID" value="OXR44001"/>
        <property type="gene ID" value="B7C42_03557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NERD" evidence="3">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="193"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="511"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1490" mass="165027" checksum="8AEEE4F837442BB5" modified="2017-10-25" version="1">MESRWTAVTESSFEHERRGLEAIRTQLPDVDPWLAWSNFTFTASTGHIREVDLLVVAPNGVHLIELKDWSGRLHSRNGDWVQELQRGGTRYHRSPLHLANQKSKELAGLLASHGVRVFVGNAVCLTNPNLRFELPEGDRANTHTVRELIDRLERPVRDARHRIDVQRSKSIKHALEQIGIRRSDAEFTVGPYRLERKPFDAGATWQDYLGTHTELREPARVRIYLRERGADEAQRRSVDDAARREASVLRRFTHPGVVRLELFDPSGHSAGPALIFRYHPETLHLDEYLLRFGHLLDLSDRIELVRQLAETLRSAHGARLFHRALAARSIHVLPRPGSGDAQRWSNPRLQISDWQTATQRSQGTGATMTRHAPTALSAQHLGSSADVYLAPELQAVAPDPIAMDVYGLGMLTYLLVTGKPPAGSQAELLAQFEAGKDLRPSALVDNLAPDIDLLVATATAYQPSKRLSSMDEFLDLLEDVEDALTTPDEPDAEPDKDPLEAVPGDVLAGRWLVRRRLGTGSTSRALLVRDLQTEDKQRGTKAYVVLKIALAPERTEVLEREAAVLRGIRRHSGVINLVDPGMIMLAGRTALVLEYVGDEQGLDNNTDGRTEETVARELRDNGRLQLGRLETYSDYLFGAVDFLEGEGVWHRDIKPDNIAIRVRPNRTRELVLIDFSLAGYPAKHADAGTDGYLDPFIGTLLRSSYDAHAERYALAVTLHEMASGELPRWGDGSVLPRQLDAKEFPYPQVAAEAFDAAVREDLVAFFRKALHRDVAQRFPELKPMRDAWRKIFLDMSRSVPSRPLSDHPVVDDVDDTTPEQQRLLIAEQATRDTHLSQAGLTAASEQFLYGLGVTTVGELLDYGRTRLINAPGLGVRARREIQERVKEWAKRLGKQEPAPLTPEARKEAKAEISAARAESTAGLMRTLSLDTLAARFVPELNKDESNSDKVNAVARLLRIPGSGDLPELDMWPTQTAVAQSLDLDVGPVGRLLRAQRQLWKKDPAVQNLRTQVLELLEGFGRVAAATEVADALVTRLGTRLLDRNDRRALGLAAVRVITEVEQFVPDEAAILVAQKREKGLDPVVVLALEVGDDTDPDTPGARALTNYALKLGEAADVLARHESVPTAAVVLERLVTVERPPGRSTIDERRLVQLAAASSRTAAVTPRLEIYPRDLPLERAIRLTQAGLYVPSDLPREKQAGLRAETVFERILARFPELVIAGSDRKLPTPELTKALCDAGFDLVVATNADTREPRYIPKHLDRASSYTAHTPRWSTATTSQFADTYSDDPDLAKAARAEELLAGAAIREGFRVLTCPTAPPHSTPDAIRELRDRFGANPISVTALFLANMHDLVPPGRKPTWSTILRADIAESGSKAALKFSEYARTAWGRVEKELGASIRTDGPLLLHDTLLFARYDAMGVLARLAERSRRGAGTLWLLCPQADPSRPPHLGPTAVPYQSALNEWIPLPQSWTSNKHRAPATTESGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5F1</accession>
    <name>A0A231H5F1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase</fullName>
            <ecNumber evidence="4">1.1.98.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dprE1_3</name>
        <name evidence="3" type="synonym">dprE1_4</name>
        <name evidence="4" type="ORF">B7C42_03626</name>
        <name evidence="3" type="ORF">B7C42_07983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000050">
        <property type="protein sequence ID" value="OXR39949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777258.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39949">
        <property type="protein sequence ID" value="OXR39949"/>
        <property type="gene ID" value="B7C42_07983"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44070">
        <property type="protein sequence ID" value="OXR44070"/>
        <property type="gene ID" value="B7C42_03626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016899">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="427" mass="46401" checksum="046EF4BFD9EC4949" modified="2017-10-25" version="1">MSTTLAALPEEYLPRDTADVVRTVRDSRPQPLTVRGGDHSSEQLDDEPAPPDRRIVMSLRRMNRVQAVDADARLVRVQAGARLSDIDRTLAAHGLGLPIVGDHREITAGGFAAVGGLSAASHRYGMFSDNVVALEYVDPEGRFGTCGRTHHADRFRRILGGAGRTGIITALTLQAIEVDKDHTWLTSDAHRFLDFDTFVEHSHAEITRPGDALLQVGRWVDTAPLRVSRPVGTGNIQLGTVRFGQWSSLHPTTATPSLRARRELGARARKSLGAIASAAGGRAGMPVRNAAAGALMFAPKVLTLRDAEYLADTVISSSERGPAYRVAVFAPMSSYSTVFHRLHDLFADHRERSGAITVISAMTYGVRSPDLHESAGEDHGFITFTCRLRPTGTYSGRSGAPELVRDITSGIDDICRSERARRYHTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5T7</accession>
    <name>A0A231H5T7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">trpB_2</name>
        <name evidence="11" type="synonym">trpB</name>
        <name evidence="14" type="ORF">B7C42_03781</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777534.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44221">
        <property type="protein sequence ID" value="OXR44221"/>
        <property type="gene ID" value="B7C42_03781"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="72"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR44221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="424" mass="45221" checksum="14EE2945443E8C9F" modified="2017-10-25" version="1">MTGVHEQLPQASEGVTHRSHEPDIGGHFGVYGGRHVPEALMAVIEEVSAEYDKSRLDPDFLAELDRLQRDYAGRPSPVFECKRLSEHAGGARILLKREDLNHTGSHKINNVLGQALLAQRMGKTRVIAETGAGQHGVATATACALLGLECVIYMGAVDTARQALNVARMRLLGAEVVSVTTGSQTLKDAINEALRDWVTNASETYYCFGTAAGPHPFPLMVRDFQRIVGLEARVQVQTQTGRLPDAVVACVGGGSNAIGIFHPFLDDEGVRLVGYEAAGDGVETGRHAATFAGGRPGAFQGAYSYLLQDEDGQTIESHSISAGLDYPGVGPEHAYLKDIGRAEYRPITDVEAMDALLLLSRTEGIIPAIESAHAVAGALQLGRELGSGAIILVNLSGRGDKDMDTAARWFGLFDDAAAPEENRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5V9</accession>
    <name>A0A231H5V9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777276.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44086">
        <property type="protein sequence ID" value="OXR44086"/>
        <property type="gene ID" value="B7C42_03642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="15993" checksum="BEA9A688C303C2A0" modified="2017-10-25" version="1">MTDFADLDALAAAVGTELGVSDWLQVDQERINTFADATGDHQWIHVDAEKAAQGPYGHTIAHGFLTLSLLVPLTNQATTVGGITMGINYGLNKVRFITPVPSGGRIRARVHLDSVSEIPGGIQAVRTVTIELEGADKPACVAESIVRYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H622</accession>
    <name>A0A231H622_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44329">
        <property type="protein sequence ID" value="OXR44329"/>
        <property type="gene ID" value="B7C42_03890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="666"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="740" mass="80628" checksum="18BA98EF87ECAA5F" modified="2017-10-25" version="1">MRHEHPLSPPGSAAPSGPAFVGRGDDVDTLRRLLGEQSARLLTLIGRAGVGKSRLAREVLWYSEFRDRLIGFLDAAPGTVTVEPRQVASAFSELAAVIGAEARIVLLDNCDPVARELAPHVGQLLDRCPQVRIVVTSREALRLPQEYVVLVRPLAVDTGLLNYDPGSSPASRLLLASIDSHYRRMHSLADRLVLDEIVRELDGVPLALELAAAEIARVGPARALRRIKAGVDLQSPALGSAPTRHRTMHDAVEWTIGDLDAHVVDLLLRLSLFETPFDIELAYRVSVLDRGRTTAALDVLFERGLIHRVESGTDIGSCRVGATVRSYCRRVDAADPARAARLRTEFAERVLVAGPRTNRRAAPDSLLTTINQLIAVGQAERAIETIALLDPVWSQHGRVRELETVLSGLLAPRTEPLAGVSAALCRELLGLWALRTDRLHRAMRMLTAAGQAYREAGDEFRAARTGVPLAAALCALGDVESAQHCLALSSRFAGRLSERFADWMWITEALAGLPARAEGWDEVAARIRRCAGSIRLSALNALARSQIGGPTPDRSLAVYREVLADEGIADHVVSAVIAIEGCARVYDRAGAAHHEHSARLWLAARRLRARHSIPQLDPEDVPGSVHRLRTMLGPERFREIAAQVNHWTVADAAACSLSAPATLEPADSRLDVLTARQREIAELVATGLTNRMIAKRLNLSEWTVVNHIRQIMQKLDCRSRLHVALVVQGDEHAVAADSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H656</accession>
    <name>A0A231H656_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44287">
        <property type="protein sequence ID" value="OXR44287"/>
        <property type="gene ID" value="B7C42_03848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="354" mass="39494" checksum="C432C3E31F9D5B03" modified="2017-10-25" version="1">MVLPGYRVHASTLETSRIRNGPAPECFSRIPDIHYGDRTSNATTGWLPETGSIVREAKDISVTGSTLARRALGRELRRLREAKGLKQAAAARAAETSPQSIGRIEEGLSTRTTGLQVNALCDFYEASDEDRRTLLGLVSEVRASRERGGGWWRAYADELATDFDHYFALEEAAQRFTAWKLSVIPGMLQTAAYRRALAWAEAPDAPTEQIEMRVQIVTHRQTRLSDDTFTVDVLLHEAAVRDQVGGPAVAAEQLHHLAEMSERPNVSVRVVPFDARRHLGSMVGSFILLEFPDLPLSKLTEPPIIYVEEYAGDLYLERPEEISRYRHALEEIGRVALDQDTSRDLILAVAKEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6M4</accession>
    <name>A0A231H6M4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor KstR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kstR2_4</name>
        <name evidence="6" type="ORF">B7C42_03287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041860.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44498">
        <property type="protein sequence ID" value="OXR44498"/>
        <property type="gene ID" value="B7C42_03287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="25818" checksum="5D442F897F8897E4" modified="2017-10-25" version="1">MDQANAWLYYGRVTASEASKSARRNELLGLAAGLFAERGLRATTVRDIADAAGILSGSLYHHFDSKEAMVDEILRGFLDDLFGRYREIVASNLSPRATLEALVIASCESFDRWHSAVAIYQAEAKRLSDTPRFDYIAEYNREFRELWRNVLTEGVRDGSFRPELDVELAFRFLRDTVWVAVRWYQPGGRITADTLAKQYLTIVLDGLTNPENRSGAVHSGAQSGAESGTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6R4</accession>
    <name>A0A231H6R4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl aminopeptidase BI</fullName>
            <ecNumber evidence="3">3.4.14.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dapb1</name>
        <name evidence="3" type="ORF">B7C42_03361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44571">
        <property type="protein sequence ID" value="OXR44571"/>
        <property type="gene ID" value="B7C42_03361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="504"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="725" mass="80377" checksum="2FF7D858BDA7458C" modified="2017-10-25" version="1">MALDSGTGTIQNAGDDAAAVTPPVAKKVPAERTHHGDTFVDFYEWLRDKDDPEVIAHLEAENAYTDAQTAHLAPLRARIFDEIKSRTQETDMSVPARLGDYWYYSRSFEGKQYGVHCRCPIADRDDWTPPQLEVDIEIPGEETLLDSNVLAEGHDFFALGAYSISHDGTLLAYSTDTVGDERYVLRFKDLRSGELLGDEIPGTAPGATWSLDGTHVFYQTVDESWRPDTVWRHRLGTAKTDDVPVFHEPDERYWVSIGATRSEKYLMIWVGSKITTEGWILESDDPEGEFRVLLPRREGVEYSAEHAVIGGQDRLLILHNDVVDGVKAENFVLTEAPVDDPAAMTMLIGHRDDVRLEDVDCFRDHLVLSYRREALPRVAVWPLTSEGYGELRELEFGLELFSAGVGSNPEWAQPTLRLGVTSFITPMQVFDYVPATGELMLRKQQQVLGGYDPDDYVQHRDWATAADGTRIPISVVRRRDSEGSGPKPLLLYGYGSYEASIDPGFSVSRLSLLDRGMVFAVAHVRGGGEMGRLWYENGKTLTKKNTFTDFVSCARHLVDTAVTTPQVLVADGGSAGGLLMGAVANLAPELFAGILANVPFVDPLTSILDPSLPLTVIEWDEWGNPLEDPQVYAYMKSYSPYENVAAVDYPAILAITSINDTRVLYVEPAKWVAALRATKTGDAQLLLKTEMSAGHGGVSGRYEKWKEVAFEYAWVLDRVGLGEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H725</accession>
    <name>A0A231H725_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloalkane dehalogenase</fullName>
            <ecNumber evidence="2">3.8.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaA_1</name>
        <name evidence="2" type="ORF">B7C42_03382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776025.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44592">
        <property type="protein sequence ID" value="OXR44592"/>
        <property type="gene ID" value="B7C42_03382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018786">
        <property type="term" value="F:haloalkane dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="31873" checksum="26A33EBC2020A90E" modified="2017-10-25" version="1">MGISTSLGPISHVTVPGGRIRYHDTGSGSPVVFVHGLLVNADLWRKVVPDVAAAGHRCLTPDWPFGSHSEPMPAADLSPTGAADLIAAFLRELDLTDVTLVANDTGGAITQIMLSRDRSRVGRVVFTNCDAYEKFFPQPFTPLPRLSRVPGLLTAILQSLRFRPAQRLPLAYGLVTKQPLPHEIADSYLLPSRNSAAIRADLRRFLRDIHKRHTLAAARTFGEWDLPVLLAWAPEDKVFRLDFAQRLAHDLPDATLRTIEDSLTFISEDQPELLSRLIVEFTRLHATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H776</accession>
    <name>A0A231H776_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776311.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44695">
        <property type="protein sequence ID" value="OXR44695"/>
        <property type="gene ID" value="B7C42_03489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="94" mass="9517" checksum="FAFDCB0B8C144FF7" modified="2017-10-25" version="1">MSLMDTLKGLVGKGRDAASQNADKVHGAVDKAGGFVNEKTGGKYSGHIDKGTEAIKKNITQQGGNTPPPAPEPPAAPPQTPPATPPQAPQPPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7A1</accession>
    <name>A0A231H7A1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative citrate synthase 2</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">citA_1</name>
        <name evidence="2" type="ORF">B7C42_03466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776197.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44672">
        <property type="protein sequence ID" value="OXR44672"/>
        <property type="gene ID" value="B7C42_03466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="380" mass="40833" checksum="43AFD1EBF0E77C7E" modified="2017-10-25" version="1">MTTSAAAPTGPAVPPDFVSGLEGVVAFTTDIAEPDKDGGALRYRGVDIEDLVGNHVTFGDVWALLVDGRFGQGLPPAEPFPLPVHTGDVRVDVQAGLAMLAPIWGYQPLLDIDDATARENLARASVMALSYVAQSARGIYQPAVPQKDIDEASTITERFMRRWKGDPDPRHVEAIDAYWVSAAEHGMNASTFTARVIASTGADVAASLSGAIGAMSGPLHGGAPARVLPMIEEVEKTGDARGLVKGILDRKEKLMGFGHRVYRAEDPRARVLRATAKRLDAPRYEVAAALEQAALAELRERRPDRAIETNVEFWAAVILDFAEVPAHMMPAMFTCGRTAGWCAHILEQKQLGKLVRPAAIYTGPAPRTAESVPGWDTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7D1</accession>
    <name>A0A231H7D1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <ecNumber evidence="4">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">accD3</name>
        <name evidence="4" type="ORF">B7C42_03484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776238.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44690">
        <property type="protein sequence ID" value="OXR44690"/>
        <property type="gene ID" value="B7C42_03484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="245"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="506" mass="53392" checksum="1F57793D490D0E23" modified="2017-10-25" version="1">MKISAREFFDGVLDPGSYRSWDREPIEIATAPAYHAELTAAAERSGTDESVLTGEGRLRGRRVAVIACEFGFLAGSIGVAAAERIVTAVERATALGLPLLASPTSGGTRMQEGTVAFVQMVKIAGAVAAHKSAGHPYLVYLRDPTMGGVFASWGSLGHMTFAEPGALIGFLGPRVYEALYDRPFPEGVQTAENLYRNGVIDGVVPVRFFRRIAHRVLNVAVPVAGQANSLSIASTAQGVGRVGSPGAEGVETPAWESVLISRDPRRPGIRELLRQASDRVPLSGTGQGESDRAVVHALARLRGEPCVIFGHDRAGRTGENTMGPAALREARRSMHLAAELHIPLVLVIDTAGAALSREAEERGLAPEIARCLADLVTLDTPTVSVLLGQGTGGGALALLPADRVLAATHGWLAPLPPEGASAIVFRDTAHAAELAAAQRVRAADLLADGVVDRIVAEHPDAAREPIDFSRRMVAAIAEELAALRARPTAALRASRRNRYRRLGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7G4</accession>
    <name>A0A231H7G4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776314.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44697">
        <property type="protein sequence ID" value="OXR44697"/>
        <property type="gene ID" value="B7C42_03491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011266095" evidence="1">
        <location>
            <begin position="27"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="21953" checksum="D87AC7B06D39C02A" modified="2017-10-25" version="1">MFLRKFAAVALPAVVAVALGAGTVHADTGAPTVRYETHLTGNTVETTLDGGFFRVDAEGRTVDVTDADGRTLVTLPLSFRQDGLEYPMPHQVRNDSRVLDLTVVKDAAAARPAPVTPVASPRENQNAMNAFATQFGLATAIGSFVGTAAGAVIGGVLGAAVAAPTGPGIIAGFITGATVGAIIGTIVVGGPALIIAGVDLVSTLAAPAGTTKWNDTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H821</accession>
    <name>A0A231H821_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44940">
        <property type="protein sequence ID" value="OXR44940"/>
        <property type="gene ID" value="B7C42_02897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="12721" checksum="B9D240B4993D8D45" modified="2017-10-25" version="1">MLSRVRRIDPVRTRRAADALRLPEAVFKTCPWQPRDVVETGLRQWLRCCGVPMATQLGRTVVAWSIVADPGEKCVLWDLDAVVGVENPWGVPPERVAEVETALGEIAGGAPHRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H827</accession>
    <name>A0A231H827_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thump_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45031">
        <property type="protein sequence ID" value="OXR45031"/>
        <property type="gene ID" value="B7C42_02988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="339"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="415" mass="45525" checksum="1235ECA19E99B44B" modified="2017-10-25" version="1">MGYSFTSRDVDYLDSAPGRDALSAVGERALTPATMLRDLDTLRRDYGDRTAALVETVQLRRRAAAKLDDAARWLFTDDALQQATPSRVARHRARRLAGRAVHDVTCSVGAELAALRRECPAVLGSDLDRVRLAMAAHNLADAPNVALLQADALRPCSTGTVVIADPARRAGGRRTHDPDRLQPPLPQLLAVHRDRDLVVKCAPGLDFDRFALRRPDAQPLPARADRTAADGYAGLSWDGEVEVVSLDGAVREACLWSRGLTESGVTRRATVLHSDGSSWSLTDAEPDDLPEREPGTWLVDPDGAVVRAGLVRHYAARYGLWQLDPRIAYLTGDTVPPGVRGFRILDRLEFREKALRAELHRRDCGPLEILIRGVDVDPDALRRRIKPRGSTPHTVVITRIGRTATAFVCETPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H878</accession>
    <name>A0A231H878_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fadA_7</name>
        <name evidence="7" type="ORF">B7C42_03101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45144">
        <property type="protein sequence ID" value="OXR45144"/>
        <property type="gene ID" value="B7C42_03101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="282"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="42031" checksum="1ECD1D92A0C45045" modified="2017-10-25" version="1">MSTEAFIYEAIRTPRGRGKVGGSLYGTKPISLVVGLIGELRRRHPGLDPAVIDDIVLGVVSPLGDQGAVIARTAALSAGLPHTVAGVQLNRFCGSGLEAVNTAAQKVRAGFDRLVVAGGVESMSRVPMGSDGGAWALDPATNLATYFVPQGVGADLIATIEGFDREDVDRYAVRSQQLAAQAWAGGYFAKSVVPVVDQNGIIILDHDEHMRPGSTVESLAKLPASFATVGAVGGFDAVALQKYHSVEQIEHVHTAANSSGIVDGAALVLVGNEQVGKDLGLTPRARVVATATSGADPTIMLTGPTPATHKLLDHVGLTPEDIDLFEINEAFAAVVLKYQKDLKIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRDARRAVITLCIGGGMGVATLIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8G0</accession>
    <name>A0A231H8G0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042896.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45016">
        <property type="protein sequence ID" value="OXR45016"/>
        <property type="gene ID" value="B7C42_02973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="15281" checksum="6829ED392A838B3A" modified="2017-10-25" version="1">MGNEHVRASDADRETIVERLRSAMNEGRLNLAEFDDRVQQVYAARTYGELSPILSDLPAVRERPDAARPGRVPPWVLIMWTPWVFVNILCVVIWLATGAGYFWPFWVEVPWGLALCIPTVIGITVGRNRAPRPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8M2</accession>
    <name>A0A231H8M2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45132">
        <property type="protein sequence ID" value="OXR45132"/>
        <property type="gene ID" value="B7C42_03089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="59" mass="6470" checksum="2B050852244DABB3" modified="2017-10-25" version="1">MYVNQYSELPRGGSGRWTRTARGSRPLTVETEASTMNPYVLIQNLLNQLDLGSAGISAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H982</accession>
    <name>A0A231H982_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45409">
        <property type="protein sequence ID" value="OXR45409"/>
        <property type="gene ID" value="B7C42_02534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="546" mass="56816" checksum="53B098CE402004B8" modified="2017-10-25" version="1">MTLNVSTDASVDKILDEGCTGLMFFQEYLPRYAQVNKLLGLGRAEMPSYESLCAKYDTERGMDLAALDGVAQDLSRVVGEANTELELQKTQLGALPSIWQGTAGDEAHALLDQQVRRAQTDYDQVKSASLGLAFASGSLRNAVMGKAEAVKKYWKEDGPDFDGSAGRQKIDWMIMVAAEYKNPGAYGPMVSMQIAKQYGPTATDWLRTVFVRGVEDIVQSFDALCTRTKGTIEQLYGGISDALDRLDVSAYPMPAGTPPPSNPGPSPGNPGPAPANPGPAPANSVPSNQSTPGNTVPSSVSPTVTSGLDGLAQISQIASQLSPVVSTLGQSLTQGATALSTAIQQGFDGALQQVQSLLQPHDAKGAADGKPNAEFDIAGRHLKFEMGPNGELEVVMSDSSGDEKTYSMKLDEHGNPVINTEDTKPGAEGDTGKPGGDGQPSGEGQQSGDGRKPDDTQQKQDSGVGKPGSDDQAPPPPKPTEQQPPAGGGQSSENGGSQVNPTTPPTTPPPPRRDSETDHKPPAGPPQAPPPDPSGSGAELAEAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9F0</accession>
    <name>A0A231H9F0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45485">
        <property type="protein sequence ID" value="OXR45485"/>
        <property type="gene ID" value="B7C42_02610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="989" mass="97400" checksum="D1231F2B21097B29" modified="2017-10-25" version="1">MTLPNADTTEWTQILGAANSGVLQFDTKDIKAATDAAAQLIANLEALAQSVHDTRAHEVGAFSILQSSRDLAGVYSNHGAALYNSLMTHANVVRDQFDTFVAAGKTFAAHENSSTFNFDTIAKPKDVKSNVTPPKLSSNGGSLVADLSQDLVDDSWSMPSFPEAIQGYGGKTDSVTINIENPDSLDWDQMIQLGQTIHAQPPMDLSGFWDSMSKLISSNMATYADQIAKLQASWTGAASAAAVTAVRNYKDSTQDLIDAIKVTGASLRYTSDWLEATRKSMPTPGQPEKTGCKHHHTDEYRANYKKYYADPMKSTISTIPTIAIPGQAGGGSTSGSGSGSGSGSGSGSGSGSGSGSGSGYGSGSGYGSGSGYGSGSGYGSGSGYGSGSGYGSGSGYDSGSGYGSGSGYGSGSGYGSGSGYGSGSGYGSGSGYGSGSGSAATSQQLQAAYEQGYEAGYQEGSHSSGSGSGSGYGGGYDSGSGYDSGSGYGSGQGYGSSQDYGSGQGDGSGQGYGSGEGYGGGADYGSGSDYTGSGYGGGTGGGYGGGSGASSGSGRTSKSSQIPSNYDSMPGSGESNQQLPNLSDLLNSAGLGDTGGSSGGSSGPSSTPYSGPSGSGTGSSTGTGSTSGTGSSAIPSNLGKTQQSGAGAAKNGQQQLPSLDDLLSGLAGEQNTEAGTGTTGDRLGQTVPSFGDSATTGSSNPLQSLLGGTGTTNPLESLLGGTAGSSNPLESLLSGGEQALNQLGQTAHDSLTGLGQLLSGIPGFDQLLASNPELSHLLAGIPGLDQLVSGSTGLDQLLSGNPDLSHLLSGIPGLDQLLSGTGATDPLHSLAERLRDLSHTPGMEGLSDIAAQLDPGGGGDSAGGGGESAGGGGADAGGGAGGGVGDGTGPDDVTPPRQLDQPRQPDKFPRASLPADVSSYGGGHHDSYDQQAGQPGQPGQPGMAGTPASSAGNSGPQGQHRRPKYLTSTDWLDDAMGDTPFRVKPVIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9L5</accession>
    <name>A0A231H9L5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">adk_1</name>
        <name evidence="6" type="synonym">adk</name>
        <name evidence="9" type="ORF">B7C42_02617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776504.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45492">
        <property type="protein sequence ID" value="OXR45492"/>
        <property type="gene ID" value="B7C42_02617"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="20247" checksum="B9CB197FF8D7AEAA" modified="2017-10-25" version="1">MRLVLLGPPGAGKGTQAELLSDKLGVPHISTGNLFRANISQQTPLGREAQKYLDAGNLVPSDVTNRMVESRIAEPDAVNGFVLDGYPRTVDQAEALEKMLKESGHALDAVLSFEVPEETLVERLVERGRTSGRTDDNETIIRNRMNVYREETEPLLEHYDGLVVAVDGVGEIAEVNTRALRALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Z5</accession>
    <name>A0A231H9Z5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-arabinose transport system permease protein AraQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araQ_2</name>
        <name evidence="6" type="ORF">B7C42_01953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043767.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45661">
        <property type="protein sequence ID" value="OXR45661"/>
        <property type="gene ID" value="B7C42_01953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="60"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="29852" checksum="89081A589388F560" modified="2017-10-25" version="1">MLLYLALVVMAWCALFPLLWALSSSLKKQGNISDTSIVPAHLAWSNYRDIFDLMPFGRIFFNTVLYAGCVTAGQVFFCSLAGYAFARLPFKGRDVLFVAYLATLMVPTTVTVIPQFILMRTFGWVDSPLAMIVPGLFGSAFGTYLMRQFFITLPVELEEAAILDGCSVWQTYWRVLLPHARPAVMVLAVLTWVTVWNDFLWPLVMIQRDEISTLTLGLVRLQGQYETNWPILMATSILMVAPMLVIYAFAQKSFVRGIAMSGMGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA16</accession>
    <name>A0A231HA16_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acd</name>
        <name evidence="9" type="ORF">B7C42_01982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.32" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45690">
        <property type="protein sequence ID" value="OXR45690"/>
        <property type="gene ID" value="B7C42_01982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="226"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="362" mass="39761" checksum="481005132F933AD9" modified="2017-10-25" version="1">MDFRDSPAEAEFRDRLRRWLSEVAGDFPTSGDEYWVRQGEWHRALYEAGFFGSSWPKEFGGHDLPPVYDVIVDEELARAGAPPRPSLGYLIQGLGHHGSKELQQRFLPGMIDGTERWCQGFSEPGAGSDLAALTTTATLDGDYYVIHGHKIWTSYSDIADWCLLLARTDPQAPRHRGISAFIVSMKQPGVQQRPLRMISGITTEFGQVGFDGATVPADRMVGAPGEGWKLAMTVVGHEREPSTLGYSARYAKTVRVLADRVDGPMPDELTWAAVQSEMLRLHVRRRLSEQLDGVSHGPDGSLDKLLMTWVDQAVGHAALSVAGTDDADMFGTYLYSRAQSVMGGTSQIQKNIIAARILGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA38</accession>
    <name>A0A231HA38_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45682">
        <property type="protein sequence ID" value="OXR45682"/>
        <property type="gene ID" value="B7C42_01974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1410"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1449"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1476"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1510"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1546"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="4">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="857"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="891"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="941"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1574" mass="168306" checksum="2098B55483BA74FD" modified="2017-10-25" version="1">MGRVFISHAGAETAQALAIKTWLIAQRPELEGEIFLDRERMGGIPVGTRWKDALARANARCEAVICVVSQRWLSLRECVVEYRTAETLGKRILPVRLEPIPHGEDMTREWQACNLFGDPATAITVEGFAEPVLLNTDGLHRLLIGLREASIGAETFAWPPDNDPGRSPYRGWNPFDDVDAAVYFGRDTQILQGLNRLRGMRAAGTVALFAILGPSGSGKSSFLRAGLLPRLAREDRRFLVLELVRPERDPLTGPRGIAASIHASRVRFGLPTPPLGTIKAAVRDDPAAVSRLLTELQQQAMRRDLTDPAPPTLVLPIDQAEELLLPDVDGGRTLALVARLLTAQTQLIVAMTVRTDRYHLLQTAPQLNATDIVEFGLAPMAHARFGEVITGPATRATRAGTRLELAPDLVDYLLADSAEGSDTLPLLALTLARLHEDYAGTGLLTSADYRSLGGLRQVVQSEIDSVLSADPKRRREQLDILRTAFIPHLAGISADADQPVRRIARWDELPEAARPLIDELVDRRLLVKDDGGGETTVEVALESLLRQWGELAGWLSGQADELRTADSLERANAEWIRQGRNDAWLLTGPRLAEAEQLAQTPGFRERTAPAREFLAAARRRENARLEDEIARREAELRIVQQRADALRARARMLVALVVVALFGAGLAGIGVYRATAESKRAARAADDSLAARLVTQAEQQLTTRALPGGDRRALWQILAANRLSPGTAASALVAAQYQARSITKIFGDAVPGARLAMSPDSRWVATSELLGSITLWDNASGTLRTVPDIAPAPGSTEQPCRVPSPPVPRVCAGLPGAVAVGADGRWVVAATHTDQLIVWDTVTGAARKIGMPGKSEVTSLALSPDGRWAATGALDGPLRLWDTTTGTVRSASGHLSTVGEVAISADGRRVAANTDLGVVRVWNTDSDALVDMPDSTGHDTTAVALSPDGRWVGSGRVDGSARIWDTVTGDIVRTSDTGSHAVRAVSVTPDGRRLATGDTVGAVALWDTGSGAVSHMAQTGRDAIDVVTIGPDGRWVDSDAAGVLRHWDTTDGGAQTISVADAFGLRVIDPDGRWVAVSGRDDVIRLWDADSRSVRELRTATGRPPRAVAISRSARVMVTGEADGAVLLRDTVTGDIRPMPDSGHTTVTSVAISPDGRWVATGDGAGAVRIWDTTANSVRAAPAADTPAEIHPAAISPDGRWVILFDRATGDLRYWNTVTGHIGTGSTRLQGFSPAIATDGHLVIAGDDTGTLYVFDLTSGDVHRTTMGTHLVTAVALSPDNRWVAAGDAGGAVHVWNTDGGQPTTVPATQLPGAIQGLAFDAANRAIRIVTDRSEVTAIPAPQADSRAICAKMTTDMGDLLWRDMVANQVAPMKLCDGLQPSPFTIPDSILHGPAPRPETTSAGPTTNPVSAIVAAALLLLAVPVSRYARRRGWLPHRPAELRVRTAPVVVGAYAIVLILSSGFCVAYGVTTHHLAWLIPAVFFLLPAWWAWIAVRAIHRSEPESISNAMTGLVMSLGPFVIVELIHVVMQFFPQTQDVRLTFADLYLTAVVAAAVPVLLRLAAVARRADAGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAM0</accession>
    <name>A0A231HAM0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetolactate synthase</fullName>
            <ecNumber evidence="5">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">xsc</name>
        <name evidence="12" type="ORF">B7C42_02078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45786">
        <property type="protein sequence ID" value="OXR45786"/>
        <property type="gene ID" value="B7C42_02078"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050487">
        <property type="term" value="F:sulfoacetaldehyde acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="192"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="391"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR45786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="566" mass="61305" checksum="44783B9BD4F3E883" modified="2017-10-25" version="1">MKVYERILELFEAEGIDTIFGIPDPNFVHLFHRAEERGWKVVAPHHEESAGMMAEGVSRMTGKAAVCIGTLGPGIANLSGAIMCAKVENSPIIFLGGQRARITEQRVRRGRIQFVQQAGLVENSVKYSASIEYADQTDEIIREGLRKALSGTPGPVYIEYPSHVIEQELDLPPALPPQRYRLVGQTAGADRIAEAVEHIRAARQPILLIGHGVHTARAAESVRQLADLMAAPVIQTSGGTSYIPGLEDRTFPYGFSPSAVEAVVQSDLCLAIGTELGEPVHYGRGRHWLAGEAERKWILVEQDPAAIGVNRPIDVPLVGDLRAVVPQLVEALRDTPRTPSPELAGWIERDAARLADLAESAPSGMSPVHPARLIVEATKAFPADGIMARDGGATTIFGWTYSQAKPHDVMWNQNFGHLGTGLPYAIGASVADGGTRPVMLITGDSSFQFQIAELETAARLNLPLVCVVGVDYAWGLEVGVYKRTFGQGSLETGVHWSTGVRLDKVAEGFGCHGEYVERDEDIAPAIKRAYASGKPGVVHVAVDPKANSEEMPSYDEFRTWYAEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAT2</accession>
    <name>A0A231HAT2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781350.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46054">
        <property type="protein sequence ID" value="OXR46054"/>
        <property type="gene ID" value="B7C42_01017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="212" mass="23422" checksum="522F674D4ACB9F9B" modified="2017-10-25" version="1">MVFPIAFGWIQALLAVLFVVAIAMLVTAVLRARKAGWRRHIGRGASGLVVLLVAVVLLWAVTLLQTYLGLTGEVKAAHVVVKSVAGSDHTLDVELTLYGDGHHDETHQTYRIEGDLWVLQADIVELEPWVNALGFHSGYKVTRLYGQRLDGTAVSQHQTMLNGGDGDFFTDMRDHSWYTEPFIRSAYGNAVIAMPGSYDVYISHDAIKTRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBF0</accession>
    <name>A0A231HBF0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46165">
        <property type="protein sequence ID" value="OXR46165"/>
        <property type="gene ID" value="B7C42_01130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="463" mass="50497" checksum="039030EF52393192" modified="2017-10-25" version="1">MVRQWSGKEARALRDAKRMSIREFAAHLGVHERLVSKWEAGGARVHPRPVNQAALDTSLARSDEVVRARFAAMIDQPVIDRPGPEFEVRQGHSAHSKYSSDAELLALVDAGAMRGDALAEISERDLIMAAAHEASEHAGRAEASNVGASALEQLDADATRIAREYVHVPPVPMMVEMLRVRRRVYRLLEGHQKPADTSHLYLLAGTLSGLLANASTDLGHLDAAGEQARAAWAYAELCGHNGLRAWTRGMQALIEYWSERPRRAVALAQNGQQYADSVTAKVRLHNIEARIWSKLGSAADAERCIRAAEAARTGTGTDELHDETGGVFGFPEAKSHYYAGATYIHLGQAEPALAETLRTIELYSGGPREQRSYGAEALARVDNAAAQLINGSLDGAGDALSPVLELSEDRRIAQLEERLTGLRRRIATPRFRDAVEARRLDERIEEFCGTTVATGMLPANPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBM0</accession>
    <name>A0A231HBM0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate cyclase 2</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cyaB_1</name>
        <name evidence="5" type="ORF">B7C42_01237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781621.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46271">
        <property type="protein sequence ID" value="OXR46271"/>
        <property type="gene ID" value="B7C42_01237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="316"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="491" mass="52759" checksum="A29704851798EBB8" modified="2017-10-25" version="1">MRTRWPLYLASMLAANAFGAVLVYAFIQYGLPAPEGTPNGLRRAGLLLPALVFSIGGFLSVTASALMLRPVMRWQMRGGPPSRQEQMAALHAPLRQSILHLLLWLVGGAVLAARIIVETPELAGAVIVTECMAATIVFGFTYMLGERILRPVAAHALTTGTFDHTLTPGVGTRMAMTWGMGTFAPTIAIVLLCVTQITSQVHFSAQSLAISILLLCGVVIMQALALSMLTGSSISDPVRQLSRAINRVQAGARDVQVEVFDGSEIGLLQVGFNRMMEEAAQRRELQELFGQHVGEEVARRALEYGTELGGETRFVAVLFVDMVGSTATAAERPPTEVVSLLNEFFRVVVDVVDRHNGLINKFVGDAALAIFGAPLDRPDAPTAALAAARDLREALREVQGLDIGIGVSAGLAVAGNIGAANRFEYTVIGDPVNEASRLTELAKEHPGRVLASGSALYFADDDEQKQWISGDEVQLRGRRRKTRLAWPKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBV9</accession>
    <name>A0A231HBV9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="3">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">dcd</name>
        <name evidence="6" type="ORF">B7C42_01152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783301.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46187">
        <property type="protein sequence ID" value="OXR46187"/>
        <property type="gene ID" value="B7C42_01152"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="21712" checksum="EE68A143FD7B5A9A" modified="2017-10-25" version="1">MLLSDRDIRAELAAGRLGLEPFDEKLVQPSSIDVRLDRMFRVFNNTRYTHIDPAQRQDELTTLVEPGQGEPFVLHPGEFVLGSTLEVCTLPDDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCLFRLSSPSEHPYGSAAAGSKYQGQRGPTPSRAYMNFPLPQDSIPQPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC87</accession>
    <name>A0A231HC87_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043466.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46429">
        <property type="protein sequence ID" value="OXR46429"/>
        <property type="gene ID" value="B7C42_01395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="455" mass="46037" checksum="7E36985803CAD39E" modified="2017-10-25" version="1">MRPDAARRAAVAAAVRRPGMPRLALIRFSGQFGDGMFQAALSGAILFNPERATDPLAIAGGFAVLLLPYSVIGPYAGAMLDRWDRRMVLLIANVLRAVLIVVTAVGLWAGIRDTPLLLLALAVVGISRFVLAGISASLPRVLEQRWLVPMNSVLATVASGCAGAGAAAAVAIIGAVGAGDVAGAVAVAASACGSVISAVAAIGFARHQLGPEHRIGASGRGATAESVRAVLTGLRTGARAVAESRDCTTAMIGVGTHRIVFGANTLLMVLVLRRPDESGMSASSGLVGFGVAITAVAAGMLAAAVLTPLLIPRLGRPRTVVAGLSAALLVQATLVPPITVATGAAEHRAHQLLLVGAFLLGMAGQMVKLTGDATLQIDVDDARRGQVFALQDTIFNITFVAAVAVTALVIPADGRSLGVVAAGAGLYALGIAAIAVNSRRRTPRGSSGRSETHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCA0</accession>
    <name>A0A231HCA0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase component 2</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trpG</name>
        <name evidence="2" type="ORF">B7C42_01444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781838.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46475">
        <property type="protein sequence ID" value="OXR46475"/>
        <property type="gene ID" value="B7C42_01444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="212" mass="22615" checksum="F3C3DE91C0304B8B" modified="2017-10-25" version="1">MRVLVVDNYDSFVFNLVQYLGQLGAEATVWRNDDSRLQDTDAVAADFDGLLISPGPGTPDRAGASIELVRACARTRTPLLGVCLGHQAIGAAFGATVTRAPELLHGKTSSVFHIGAGVLAGLPDPFTATRYHSLTVLEDTLPGDIEVIGRTESGIVMAVRHRDLPIHGVQFHPESVLTQGGHRMLANWLEVCGERPAEGLVETLESEVAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCM9</accession>
    <name>A0A231HCM9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46650">
        <property type="protein sequence ID" value="OXR46650"/>
        <property type="gene ID" value="B7C42_01624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="9094" checksum="05D4FDC510A48F21" modified="2017-10-25" version="1">MNQRNQAAIPATPAASDIRADLLRRLDFLRDRLTPPQRMNMIAKLLVQFRDTIYPWMHILRRADGSLVVTINQPPADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCQ8</accession>
    <name>A0A231HCQ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">pH-sensitive adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781833.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46467">
        <property type="protein sequence ID" value="OXR46467"/>
        <property type="gene ID" value="B7C42_01436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="36012" checksum="357F6F7702911E66" modified="2017-10-25" version="1">MASPELSKLVQSVVEPYLLEGPRRYNRVEVAELSGVPSDLSRRLWVSLGFPAHDDDAAVEFTDGDVNAVRNFRSLDALAGADVRRQQAAARTLGQSMARLAEWQVDLVAEEIADRIRSITAGDPGVDQDKVAREATAEVVSALQQLQAYAWRRHLAAALTRSLAGDGTGETLRELAVGFADMVGYTRLTRHLEADELDDLLESFESVTTGAITANGGWTIKNVGDEVMFAAESAVAAGRIALAIQEATTSAGTTPELRVGLAYGQVLQRFGDLYGSVVNTAARLTGVARPGTVLVDDGAATQLADEPEFSLRNLRSVRVRGINRLGSHVLRRNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD47</accession>
    <name>A0A231HD47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46688">
        <property type="protein sequence ID" value="OXR46688"/>
        <property type="gene ID" value="B7C42_01663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="20504" checksum="D7946496D20442F7" modified="2017-10-25" version="1">MSDDILRWHAAATVVKFEPATVLDMIRHVGREPLGHEIEDLVQRGVFEPDDIHHEDGNLLTTAGLNRLTSLFEGAGGAVFNNAQAIIGVGSSTTAAAVGDTALGGNGSASTAYYQGVDTGYPTQSGGVINANATFGTSNGNFTAGWQEWCLAIATGTITPGATLASVGTSPIMFNHKVANLGVKANGAIWTLQATCTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD81</accession>
    <name>A0A231HD81_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46819">
        <property type="protein sequence ID" value="OXR46819"/>
        <property type="gene ID" value="B7C42_01797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16083" checksum="15C307A0D0A1709F" modified="2017-10-25" version="1">MYLAAKAHDGPMKSIEIELHTGDREVVHDLTPQCATFLREAGGGDGLLHVFVPHATAGVALIELGAGSDDDLLRALRDLLPADDRWRHAHGSRGHGRSHVMPALIAPYATVPVLGGELTLGTWQSIAFVDLNVDNPIRRVRLSFLRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD94</accession>
    <name>A0A231HD94_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46874">
        <property type="protein sequence ID" value="OXR46874"/>
        <property type="gene ID" value="B7C42_01853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="345" mass="36244" checksum="773C51FD607D54DF" modified="2017-10-25" version="1">MGVPTAVPVSQEPGLKLGWPDRADKARLHYVSGKGGTGKSTVAGALALALAAGGRRVLLVEVEGRQSIAQLFDLPPLPPTETKIATADGGGEVMALALDIEHAFLEYLDMFYNLGFAGRAMRRMGAIEFVTTIAPGLRDVILTGKIKECAVRTHKSGKRVYDEIVVDAPPTGRIAGFLDVTKAMAEVAKGGPIAGQAEGVAALLHSEQTVVHLVTLLEALPVQETADAIAELTESDFRIGTVIVNRATEGFLPAPVRARVASGDLDLDAVRAGLAEAGITVDDNDFQGLIQEAVEHSATLQAQDDSSAELAKVDISRLYLPALPDGMDLGGLYELAEHLSAQGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDX7</accession>
    <name>A0A231HDX7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tcmN</name>
        <name evidence="6" type="ORF">B7C42_00305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47183">
        <property type="protein sequence ID" value="OXR47183"/>
        <property type="gene ID" value="B7C42_00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="138"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="39490" checksum="0503EF64E6326100" modified="2017-10-25" version="1">MVFGLPKLPPLPLVRAVETVRYGLGEAYRRLAPAPLSLMELLAAGWLAQAIHAAAALGIADELARGPLAGAELARRVGANEDALRRLLRLLISHGIFAQRRDGRYALTPPARALCRDSPESLRDAALFFGSAMHRAHWTHVVDAVRTGNPVGPQVDGAPFFEYIRTDRQFGDLFDRAMTSIGSLTTESLFAAYDFGQFSTIVDVGGGHGAMLTEILTRAPETRGVLFDLPDVVAGGAERFAAAGFDGRAEVTPGSFFESVPAGAEAYLLKHVVHDWPDARAEQILRTVRAAMTSDARLIIVEIVLPQDNRPHPGKYTDLEMLINSGGRERTAGDYRDLLARCGFELTRITETVSPESVIEARPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEC2</accession>
    <name>A0A231HEC2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47085">
        <property type="protein sequence ID" value="OXR47085"/>
        <property type="gene ID" value="B7C42_00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="30263" checksum="ACB650EFEFD311C7" modified="2017-10-25" version="1">MVDVWLLLILLVVVLIACVAMMVAGRSNQRTRDTNQLADAKADARRLIERLGGQVYNLTGTDQASKQALADAGERLNAAGSQIDQATTVTQARLAKETAIEGLYYVRAARTAMNLDPGPPVPELDGRRSAGRVTEDRTVDFDGRSIEASPTPSPQTPNYYPGGRVAGRPVPAGWYSEPWWKTALVAGAWGVGSVLLFDALFGGMHGVGYGAAGFENGYGAGYDAGFDAGHDAGQDTGQGFDGGDQGGYDGGGYDQGGGYDGGGFDGGGFDGGGFFDGGGGGFDGGDFGGFDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEE3</accession>
    <name>A0A231HEE3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligo-1,6-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">malL</name>
        <name evidence="4" type="ORF">B7C42_00187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47067">
        <property type="protein sequence ID" value="OXR47067"/>
        <property type="gene ID" value="B7C42_00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="23"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="546" mass="59481" checksum="A48271C903C4C993" modified="2017-10-25" version="1">MGDAAGHTEESAPPWWRSAVFYQIYPRSFADASGDGVGDLAGVRDRLGYLELLGVDALWICPVMRSPMADGGYDVSDPRDIDPLFGDLATMDELIAAAHERGIRVTMDLVPNHTSDRHPWFAAAVAAAPGSAERARYLFRDGRGLDGSQPPNNWPSIFGGPAWTRITEPDGTPGQWYLHLFAPEQPDLNWDNAEVVADFEQTMRFWLDRGVDGFRIDVAHGMAKPPGLPDMDPIVVAAVGPSATQPSDADAKLLVHDDSDPRFNNPGVHDIHRRLRKVVDEYPDAVSIGEVWVDDNIRFGEYVRPDELHLAFNFRLAETPFDAAKIRAAVENSLESVARVGAVPTWTLSNHDIEREVTRYGGGASGIARAQAMIMLELALPGAAFVYNGAELGLPNVDDLPEEVLQDPVWERSGHTERGRDGCRVPIPWEGTNPPFGFTDGPDSWLPIPAGWADRTVAAQRESPDSTLSLYRAALEVRRTRAEFDGDTVDWLDAPENCLAFRRPGGLLCVLNASAAPIALPPGTVLLASAPLRGALLAPESAAWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HET5</accession>
    <name>A0A231HET5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_pol3_delta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777094.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47245">
        <property type="protein sequence ID" value="OXR47245"/>
        <property type="gene ID" value="B7C42_00367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="33321" checksum="B96408F5C872B8A7" modified="2017-10-25" version="1">MTDHLAALHLVLGEEELLIERAVASIVAQARAATNDPDAMPVDRLRAGDASSAELAELLSPSLFAEDRVIVLEAAAEAGKDAVALITAAAGDLPEGVVLVVLHSGGGRAKALAPALQKQGAEVHTCAKISKANERNEFVRNEFRTAGVRVSGDVVQAVVEAIGSDLRELAAACSQLAADTGGKVDVDAVRRYYSGRAEVTGFEVADLAVAGDRPAAMEALRWATDRGVPAVLLADALADSVHTIARVGSAGRGDPFALASQLGMPPWKVKKAQTQARGWTAATIGSALQVVAALNADVKGGAADTDYALEHALAGILDLHAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEU0</accession>
    <name>A0A231HEU0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-ketosteroid-9-alpha-hydroxylase reductase subunit</fullName>
            <ecNumber evidence="8">1.17.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hmp_1</name>
        <name evidence="8" type="ORF">B7C42_00348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47226">
        <property type="protein sequence ID" value="OXR47226"/>
        <property type="gene ID" value="B7C42_00348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="284"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="372" mass="39886" checksum="88FBE61D5A6ECCE8" modified="2017-10-25" version="1">MWWCCMDTAIELDVREPGDAPEDTGPRDSAADPVVVEIVRVVRETADAVSLELAPRPEHAQRFGYRPGQFLTLRIPSDRTGSVSRCYSLSSAPHEDGPLKVTVKRTAQGYASNWLCDNAVAGESLQVLPPAGLFTPASLDTDLLLFAGGSGITPVLSILKAALAQGSGHCTLVYANRDESSVIFAAELAELAAAHPDRLQVLHWLESVQGLPSVAQLSALARHWADRETFVCGPGLFMDAVGAAMAAHGADRRRVHMEKFVSLTGNPFEAATPVVDPADPADSAHVEVELDGENHRMAWPRRQVLLDTLLAAGLEAPYSCREGACSACVCRVVSGEVSMRRNEVLEEEDVAEGYVLACQAVPVTDDVSISYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF93</accession>
    <name>A0A231HF93_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-damage-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dinF</name>
        <name evidence="6" type="ORF">B7C42_00766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47641">
        <property type="protein sequence ID" value="OXR47641"/>
        <property type="gene ID" value="B7C42_00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="457" mass="47615" checksum="80F6AD4673F20227" modified="2017-10-25" version="1">MVEIHPEDGVTAVAGAARHDAGPRRILGIAIPTLGVLVAEPIYLLFDMAVVGRLGAPALAGLAVGGLILGQVSTQLTFLSYGTTARSARRHGAGDERGAVAEGVQASWLAVAAGLAIVVVLQVFARPVVDVIAGGADVADEALRWLRIALSGVPLILLTMAGNGWLRGVQQTRRPLVYVIAGLVVSALLCPLLVHGLLGAPRMELAGSAVANVAGQVVSAGLFVAALVRRRVPLRPHPRVMRAQLVLGRDLIVRSLAFQACFVSAGAVAARFGAASVAAHQLVLQLWNFLALTLDSLAIAAQTLTGAALGSGDASGARVLARRITVWSTLFAVVLAVIFAAGYAVVPQVFTDDPAVLDRVHVIWWFFVPLIPVAGVVFALDGVLLGAGDASYLRTTTMAAALLGFLPAIWLSLSFDWGIAGIWSGLSAFILLRLIAVSWRALSGRWARVGSEIPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFB8</accession>
    <name>A0A231HFB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47387">
        <property type="protein sequence ID" value="OXR47387"/>
        <property type="gene ID" value="B7C42_00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012579120" evidence="1">
        <location>
            <begin position="40"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31439" checksum="5F3D1DF02EEC4528" modified="2017-10-25" version="1">MHAPLRPSTKRAMAFRVCRCAAALLGASLLLSPAACSNAGDTPAATTTTRASTSSAPVTMFALPGSLAADFTALRPSLDGRAGMAIMAVGGQRTAQMGDWTTGPSWSTMKVPLTLAVLRTNGNTSTYQMSAAITESDNSAADGLWQALGAPDAAAKAVQSVLREGGDTTTTVPATRARAEYSAFGQADWSLADQVRWASRLPCLPDADTVTTLMGKVVWGQQWGLGHLDNTRFKGGWGPDPSGNYLVRQFGLLTTPNGDVAISLAAQATSGTFDDGTQILNKMAGLITKHLDDLPAGHCAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFR3</accession>
    <name>A0A231HFR3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kshA_2</name>
        <name evidence="9" type="ORF">B7C42_00936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47811">
        <property type="protein sequence ID" value="OXR47811"/>
        <property type="gene ID" value="B7C42_00936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="378" mass="42843" checksum="A04E1F3D1AA0EBE7" modified="2017-10-25" version="1">MTTTHDEVRRIEAGTVPTRFARGWHCLGLIRDFADGRPHSVQAFGTKLVVFRGEDGRVNVLDAFCRHMGGDLSDGEVKGNEIACPFHDWRWGGNGRCKQIPYARRVPPLARTRAWTTLEQDGMLFVWNDPEGNPPPEGVTIPRIAGAGDPNWTDWHWYTTVVDTNCREIIDNVVDMAHFFYIHGSLPTFFKNVFEGPVATQYFESGARDDLPGPVGQPQLLGTSSVASYYGPSFMIDDLVYHYEHGDYKTVLLNCHYPIDENSFVLQYGIIVEKSDTLPEDQAMATAVALGDWVKLGFEQDVAIWKSKARIDNPLLCEEDGPVYQLRRWYQQFYVDVADIAPEMVDRFEFELDTTRPLAAWQEEVRENVARKAAEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG22</accession>
    <name>A0A231HG22_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">dapB</name>
        <name evidence="12" type="ORF">B7C42_00792</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47667">
        <property type="protein sequence ID" value="OXR47667"/>
        <property type="gene ID" value="B7C42_00792"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="113"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="26304" checksum="C88023D6B93C9EFF" modified="2017-10-25" version="1">MATNRIRVGVLGAQGKVGQAICAAVEAADDLELVAGVDKDDALEVFTEAGAQVVVDFTHPDVVMPNLKWLVEHGIHAVVGTTGFDESRLGQVRSWLTGNPEVGVLIAPNFAIGAVLSMRFAEQAARWFDSVEVIELHHPNKADAPSGTAYRTAGIIAEARKQAGVGPSPDATTTELDGARGASVDGVRVHSVRLAGLVAHQEVLFGTQGETLTIRHDSIDRTSFAPGVLLGARQIGARPGLTVGLDPLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG67</accession>
    <name>A0A231HG67_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47716">
        <property type="protein sequence ID" value="OXR47716"/>
        <property type="gene ID" value="B7C42_00841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7299" checksum="9FDA4A5B32617BF6" modified="2017-10-25" version="1">MLLDAGSPGTRLVLSEGRVRLATDSGEDGLELIRRPELADRIGNHPDQHELAEQAELLNTLIRLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG70</accession>
    <name>A0A231HG70_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042843.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47828">
        <property type="protein sequence ID" value="OXR47828"/>
        <property type="gene ID" value="B7C42_00953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="9162" checksum="1C2B798804E713FF" modified="2017-10-25" version="1">MSEPDARDLPTGVVRAGEWSGVGNEFTGVRFRKVWTRNGERLEIHVPRTGAHILLDAMALEVVAGQAPEFFTRLIAEGLGSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG76</accession>
    <name>A0A231HG76_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47726">
        <property type="protein sequence ID" value="OXR47726"/>
        <property type="gene ID" value="B7C42_00851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="118" mass="12825" checksum="45D5679EA90D848F" modified="2017-10-25" version="1">MDVKSAVRGFNSVVLTLTEAPVLGPLMRKGFVEISYVGRKSGKTFSTPVNYRRSGDSIVIGVAMPDRKSWWRNFTGEGGPITLHLDGGDRHGRAVATRDDKGRVRVRVHLDDAAAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGB6</accession>
    <name>A0A231HGB6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518403.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47766">
        <property type="protein sequence ID" value="OXR47766"/>
        <property type="gene ID" value="B7C42_00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="6800" checksum="8D27BAC062D76241" modified="2017-10-25" version="1">MADQNNPGQFGNRSDTEEQARRGGQASTGSFGQRNAADPHEAGRKGAQAQPTAAKQAGGQHSHGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSL3</accession>
    <name>A0A231GSL3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000142">
        <property type="protein sequence ID" value="OXR39613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39613">
        <property type="protein sequence ID" value="OXR39613"/>
        <property type="gene ID" value="B7C42_08319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="89" mass="9133" checksum="F53D7362C18EDB51" modified="2017-10-25" version="1">MPGSGAMAAPGLAGVMPGSGEIMMAPVSVCHQVSTMGAVPAPMTSRYQRQASGLIGSPTEPSTRSEDRSWASGMSRPHFMKVRISVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT17</accession>
    <name>A0A231GT17_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_08160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000069">
        <property type="protein sequence ID" value="OXR39766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39766">
        <property type="protein sequence ID" value="OXR39766"/>
        <property type="gene ID" value="B7C42_08160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TIR" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="688"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1222"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1376" mass="148048" checksum="4C60BBBF57ED0DF2" modified="2017-10-25" version="1">MARVFISHAGVDRSWALEVREWLTSGGHEVFLDLDPVEGLAVGEEWERRLYERLRWADAVVCVVTPAYLRSVWCAAEIGIARATGSRLLPIRFVAGVTHPLLKSIQQADAAADPAVAREKLARSLRTIDVGGGLGWPDGRSPYPGLAPFDTDMHRVFFGRATEAAELTELLRQAATRSARSIVLVIGPSGAGKSSLVRAGIIPLIADEPYWLPLEPVIPGTDPVGALARALVVAGRGAGMDWLVESMRERLATDGLRDVAADILIATDSPPQRKLLLVIDQFEEVLGPAVAAQRTRFAELLAPAIGGPVQVLATVRTEFLDQIMVDPALAALGTRTFPVRPLRVADLREVIEGPARVAGLRIDEGLVEELLADTDSGEALPLLAFALAQLADGVQRNGVLSRRRYRETGGVRGALVRQAELALDEACAATGLSDDEVVATLLRLVTVDEQGVPTRERVPRAELSETAVAVVDAFVAHRLVTTDTAGSRIVVSVSHEAFLRNWSRLAAAVGKETTALRARRAVELAAAEWDADRRSANRLWERGRLAAAMHDTGARLRRLSRPRWRVWPPRLRALVTERIEISSRATEFLELSYRRDRLRRGRATALLSILLVAALVGAGVAVVKQRAAVEQQHTAVARQLMAQADKLIGVDPRTALRLGLAANSIHPSDETRHWLVNGLSTTRYTGTLDGPVKRVMRAVFAPNGRLLAAQHEDGTIVLWDLADPAGPHRVGEPLRGVSTLATPIFSPDSRTLLSGAGIDTDDRASGNGVAPVGHNIDWSSLHGVLAWDLADPQHPRVSGTVLPNIGEKTTLIFGPDTSIGVTAGTGQPTQLWDFSDRSQPRPIETLLPVDAEKAVAFSADGRTLAVGTTQDVTLWDVSDHRQPRRIGQYSVQVRGVLEELAFSPDGRTLAADLFYAGILLWDITDPQQPRRLGKPILDSDWGSDEIAFAKEGHVLATAPAVRNQVYLYDLTDPASPVRIAGPLIGQPAAVTTLTFSTGGRFATGTDDGRTTLWTTDIRAQPQMPGPPLAGSMDKIAGPCGVATDGSVVAIAGTNGNVDLWDIAGGGDPVETATWNTEHVDFMNDIRISCLALSPDGKTLATGSPDRTVSLWDIRNRRHPRRWGPPLTGMDGIVRAIAFAPTGDRLAIGSDQNSLEWDIYDPAAPKRLGRGLYGQQVQTLAFTTGGRLFAFAHQREQITIWNMTDSNRPARVGTLSAGAEARVAYSAAADLLVTAAEDSTGQLWDVRDPSHPRAIGDPLRPGIDTFTAVFDAKGGMLAALGLDGRIVVWDITDPSHVTRIGEPVGGLEDAVSAAQFTGDGGRLVAGYVRGAAIVWDLTAMNELRGRPAEFGCATVGSGLDRSEWNRYIQQIPYRSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT42</accession>
    <name>A0A231GT42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000065">
        <property type="protein sequence ID" value="OXR39786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782119.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39786">
        <property type="protein sequence ID" value="OXR39786"/>
        <property type="gene ID" value="B7C42_08138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="22470" checksum="F385BD488BAA8905" modified="2017-10-25" version="1">MPKVCTSRNLSITSGVLGIAKWSAPRLVAQQTATSIGDGTISSAGLTSQPGRLMIDTSVSWTSDSPLASVMRLQVIRKYRTLIASNPNAVQIWDSWNVGIDRSAVTPDSYNLVNSLTTLSWDMGTDQASQPFYARIHQHYPASASEEWYDLPAGSSIQIKYRAYCWTPPPWSNNASANNPLHEAWARGVTLRLWAFPTLDEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTC1</accession>
    <name>A0A231GTC1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778609.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39873">
        <property type="protein sequence ID" value="OXR39873"/>
        <property type="gene ID" value="B7C42_08048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="19408" checksum="812CB784DDBDC85F" modified="2017-10-25" version="1">MSNTWSREELESAFQTWHATVTRAASGTGSWREFVDLFTPDAEYHEQMVGVLKGPDAIWAWAEPTLAQFPGSAMTSFPEYWHLIDDVNGVIVVKLNNLMRDPGDGSQMGADNISILTYAGNGKFSKEEDIYDPAEFVRLVPEWCRRAMELGTLSEAELAWCKQALPAAESDSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTS8</accession>
    <name>A0A231GTS8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypco2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39955">
        <property type="protein sequence ID" value="OXR39955"/>
        <property type="gene ID" value="B7C42_07962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045608">
        <property type="entry name" value="Trypco2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19631">
        <property type="entry name" value="Trypco2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="120" mass="12893" checksum="1B15EBB6F3548A6A" modified="2017-10-25" version="1">MSENSGEELAGRVSLSAAVDALRAELARAWEGAQSETVRFKPTAVELTLQVAVTSAGKAHGGIKWWLVDAGAEASRQSVATQTVKMTLEPVVFTEKGEPVTEVYIDSVRDRSPLHSTDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTU1</accession>
    <name>A0A231GTU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40047">
        <property type="protein sequence ID" value="OXR40047"/>
        <property type="gene ID" value="B7C42_07892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="492" mass="53533" checksum="929371AEBB0E1CC9" modified="2017-10-25" version="1">MTGPRMYGRWEKPRSAGFFGMTWGVSMLALALLITVMATFMITRSIPATLIVLACAAIGFTPLVITVDGRTGWETAVLRVQFAAAKARGELLYRSGRFSRIPGVARLPGVLADSRLAEWETPGGKRFAIVHIRRTDHCTVVLRVLPRGKELVDQAQIDAWVGEYGHFLASQSRGGEVVAVTSVLENLAETHLKQRREVARLVRPQAPQFARAVMREAAADIGGVGVRIEARIAITFRAIGTSRKTRQDLPEQAREIGQRLQGVLSQLARAGLPATPLQAWEVLGLVRSRYDLAAQRDIEAAGPAITDTQSWDSVGPIAHEDRWDHLVHDGARSITWEMDAPPRGAVLETGLEELLRPRADVPRKRVAIVYRLHSAAEATDIVDSDFRDALAAEQTERGIASAAASIRVDNTRAARQEQARGAGLTRFGVLVTVTDVLDADLPGIEASVRTMTAASRLRVRRCYGSQAAAFAASLGIGLILPEHTSISKRFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU37</accession>
    <name>A0A231GU37_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778630.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40134">
        <property type="protein sequence ID" value="OXR40134"/>
        <property type="gene ID" value="B7C42_07798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011277264" description="Peripla_BP_6 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="58"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="414" mass="41565" checksum="9DA4A04385FD6064" modified="2017-10-25" version="1">MKLGGLARHRRTLAGISVLALVGALGASACSSDDTSSNSAIAGASTTSLPDNPASGTPVKIGFVSTEGGAVVSIPEMRQGAEAAVQYVNKNAGGLAGHPIDLVVCKQQEEPTSATKCANELVEQKVAAVLSPGTSQGAAIVPIVAGAGIPYVTLNGVSQVELTSPESSSLSAGLPGSITAMAQAAKKQNMKTFTIFASDGGGIGAMINAMGAPIFQGAGVDLKVVPIALGVPDPTPLVTSGLSAKPDGVSVIADAGTCTSVYKAIQTADPNVQKVYIPTCLDPSVTNIIGMDTVKGSIGITATDYLSDRPDSVLYRSVLQQYAKDLNVTGAASSGYQLVMALVGATKNLQGQADAASIKQALKAAQNVEMPAGGGITFTCNGTAVPQMPSICSHQMLIGTINDKGVPVDLQVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUH5</accession>
    <name>A0A231GUH5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40279">
        <property type="protein sequence ID" value="OXR40279"/>
        <property type="gene ID" value="B7C42_07617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="480" mass="53785" checksum="FD6B3EC0C95CCC84" modified="2017-10-25" version="1">MTETSTFLDTITHLDYSITSDRRAARRTFTTALTHATPAERDVLDAMVETFTLYPFRTALLRLEAAFRYDEPKRDLLARLLPDSDPGLYVREREERIAILEQRARANGSSVEEEAFRDYAPLTAAETAPTSIRLWRNPPARVYLAPSRATDKSRMTPAQITARVRARGKRRPAPIEPDVVTGYIAEDLHRDTMGREIARTRATEQRFRDLGLLAEPASSSSLRVQGTQPRSDEDVQARWDLEFVHHVAEQHTHDAAAAEHSRRVSHDNALAYADTRTGVRGDLRPQLPFHGDSVDYTREAMTPISGWRCVACFIERSTRDQHPIHSGNGRRRSDDGLCDSCRSDDRTPRLPELPTGFTATDLARTYCQFLTTTYPGAAPALLAETRRRAPRWLTTIIDEHLPQPEHIQPAADSQAPAEPGAAQESSASRRRRGPVTGAGQRQARCEGCTRIRAIHDDGFCTECRVWLGLVTPPARHTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUM0</accession>
    <name>A0A231GUM0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40171">
        <property type="protein sequence ID" value="OXR40171"/>
        <property type="gene ID" value="B7C42_07753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="240"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="339" mass="37302" checksum="792B781B74A9E726" modified="2017-10-25" version="1">MNTRLDLPIIPPAVLSGVVEIGQREKCDVGSWFAGTGLSATQVFTDSSTKVSFRQAADVLRRAVRALPGRPLGMQVGGRDMLLSMGMLGVALRSCATLSEAIAVGIELHQVSGSLMDLELERFDNSVAIRLRERSPEPELIAFLCEEVLCSTTVLARSVIGPDWSPGRVELTYPPPPYAHQYESFLRCPVEFSATANRIVLPATALGLPLPTHDKPTQAVAIEACRRLLDLGRSGPTITVTVETLLEQNLRQPPTMTDVADRLHVTERTLRRQLADAGESFSAVRDRVRERRATYLLRESGLPVTTVAREVGYSDTREFRRAYIRWTGHSPSAARSRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUQ2</accession>
    <name>A0A231GUQ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40354">
        <property type="protein sequence ID" value="OXR40354"/>
        <property type="gene ID" value="B7C42_07520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="131"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="433" mass="44154" checksum="722950FAF290BBB8" modified="2017-10-25" version="1">MSIAFESDGRVVPNWQLLLRGLAVVVVLAVVAGLMIARSRGAFRETIEVTAELTNVGDGLPATSDVKYRGLLVGRVAGVGPPADRGPNHVRIDVFPDRVRGIPSTVTARVVPSNVFAVPALELVDNGPGAPLAAGAHIAEDRSLDTVRLQTSLTALSRIAAAAGRSGGDSTIGILTTVERAVSGRASEAVQAGAQLVRISQALNDAMAPDGTGSTLDTLSQALDGLRSSSPDLLAAVHDAVVPLRTVAQQRTQLSNLLSGGLTTSATVATALENNTATITGITGKLSDPLSVIAAGSAHFAQMTTSLSRLSGPFSGMWDPQTQTATAKIILELTPHRQYTRADCPRYGDLAGPSCTTGPPGGPTIIGPNAAPASSPTLIGGNVGESGSRQEQERIASILGGLPNAAADILFGPLLRGNNAEVRPAPDAAGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUQ5</accession>
    <name>A0A231GUQ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40360">
        <property type="protein sequence ID" value="OXR40360"/>
        <property type="gene ID" value="B7C42_07526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="137"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="43885" checksum="56E3BFA28AF1BB1C" modified="2017-10-25" version="1">MSAALEPPARAVVFTARQMSRHRILTSCVSLLVVLVLAVGYLLLGSLQVDPMRSNYRVRIALAQSGGLLPGQDVTLRGVRIGRVRSVDADSSGVVAVAAIDSRTRIPVHTHVRVASLSAAGEQYLDFRPESDAGPYLSDDAVIDQRDTSTPTTLAELLDSLNGTLTQVDPAKIEAIVRELGMSSAGPGKLAAVVDGGMFMLSTLDSILPQTVSLLHNSKAVLTAVGETAPGLQSTAQNLSTTMAGVSAMTGGYQDLLGNTPGALTAVDSLIADNSSTMVQLLGNLTTTAQMAYVHTPALQEFFFPQQRTGSTLDAIGTGLHDGAAWALVSAYPKYSCDYDLPRLPGSVPNYPEPYLNARCTDPDPAVLPRGAANAPRPPGDNTSAAPPGADPRQRADPTPRGLLTYDGGPASRGNIPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVB4</accession>
    <name>A0A231GVB4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40528">
        <property type="protein sequence ID" value="OXR40528"/>
        <property type="gene ID" value="B7C42_07337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="10"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23959" checksum="E0CEA76733D7F107" modified="2017-10-25" version="1">MSQLVRVQNFNLSSDGYGAGEGQSLERPFGHADPSALFAWCGPTAHWPTRTEPGGTYGLDDYFTRDYRNNIGAEIMGRNKFGPQRGPWENYDWQGWWGDEPPFRTPVFVLTHYPRPSITLGDTTFHFLDASPKEALKKAFDAADGADVRIGGGVSVIRDFLEAGLIDQMHIAVAPVELGGGERLWTSPDELTDRFHLERVPSPSGVTHHLFWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVK7</accession>
    <name>A0A231GVK7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40644">
        <property type="protein sequence ID" value="OXR40644"/>
        <property type="gene ID" value="B7C42_07329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="45"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="16452" checksum="5A00C58B27A944B9" modified="2017-10-25" version="1">MARCTVERLMRELGLRGAVRGRVKRTTWPDPAAPQPADLVQRHFAPSAPNRLWVADMTYVSTWSGWVYVAFVIDAYARRIIGWRTATSMTTSLVLDAIEHAIWTRERAGWDVKDVVHHTDRGSQYTSIAFSERLAEAGIQPSVGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVT6</accession>
    <name>A0A231GVT6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_07240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40682">
        <property type="protein sequence ID" value="OXR40682"/>
        <property type="gene ID" value="B7C42_07240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="14682" checksum="74F4D2FF43FC4A5B" modified="2017-10-25" version="1">MAPLVVLVVVTALARLAGAIDLADWLDSWPHALRVGLAAMFLLTASAHFQQPRRDALIAMVPPGLPSATGLVTLTGVLEAAGAVGLLIPPVAPVAAAGLIVLLIAMFPANVRAARADLGIKTMPLPLRTAVQVVFIAAAVVAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVZ0</accession>
    <name>A0A231GVZ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator CdhR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdhR_10</name>
        <name evidence="2" type="ORF">B7C42_07073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40790">
        <property type="protein sequence ID" value="OXR40790"/>
        <property type="gene ID" value="B7C42_07073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="35019" checksum="06935C14759AEF4C" modified="2017-10-25" version="1">MSAYRVGVLAYPGCFASEVFGIPDLLTMAAHVAGPDRAGYEVTVVSPRRRVVASGGVALTVSPLREVDILVVPGFELVPGVDPDARLPPLTAEIAAIRDHAAAGGAVVSICVGAFLLARAGLLTGRQATTTWLFADELAQQCPQADIRSDRLVVTDRGVTTTAAFSAMYDFALDLIARHSGPRVARTTARIALVDDARSSQTPYVDARLLPQPGNMFSRRVMRHLDRNLSIRYDLTALANTFHVSTRTLLRRFADETGHSPLDYLQSARVRRARHLLETTDRTVADICGAVGYRDAGTFAALFAAHTGRRPGDYRTTFRRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW00</accession>
    <name>A0A231GW00_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrD_2</name>
        <name evidence="6" type="ORF">B7C42_07169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40745">
        <property type="protein sequence ID" value="OXR40745"/>
        <property type="gene ID" value="B7C42_07169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="5">
        <location>
            <begin position="395"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="483" mass="52729" checksum="05646BC78F071173" modified="2017-10-25" version="1">MDIAPAGVSPDDRQPWVALNRKRAELRETLSTVDSPAVSIAVVFDSAADTRGAPRAPGRIVLSPSDIAGRDWPDRLPKAPLSDDAFATITDLLAPSVVFGKAARMGAVDPEARGRAAHRLILDAAQSAIATAPIADVSVVAGPPGSGKTLLLAARARELRRTHPSWQIAILVYNRGLVPYLRQLVDDPHVTVSTLGKFAHQLGFRLSLSDSEEAAHDLRKARARGIPRAVDALLVDELQDFDPAWLAFALDTVRPNRGGALLVGDRNQGLYREHNLEETLRGRDVARLELTKPYRSTRQVLRVASVITGQEVVGIDTALDGQPVDLIWADSAEAQVACVAWEIAQMLAGETRRPRDIAVLMSQWRGLRRLREALSEAEIPFEVFDKRQVDAFDLATPTVKVITVHSGKGYEFPVVFLVGLETLPAGSDGPTRLRERVGFVGATRAQDQLLITYTDSTVHVDRLAALDGDIERWTWPDDYAECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW36</accession>
    <name>A0A231GW36_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776991.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40843">
        <property type="protein sequence ID" value="OXR40843"/>
        <property type="gene ID" value="B7C42_07127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="229" mass="23111" checksum="13340B4EFD1D027F" modified="2017-10-25" version="1">MPLGPEARVDSGAAGHPLLADAAHTALEAGRLIARTAGAAEKVGAEVAKAGEGATKAAAEAEKGAAAIALPEVSWKVAIAAIAALLVVAVVVIRSCAVNAPPMIGQLTPVEALPDLVRAASSCRHVDSGPAVDNCVIAADHPLLSGGITDGRQLTFTVRADPPQNLTAVVNGWRVAGGTVIADGTVFVAIGPSATVWYADTRTGLRIETATFANRAGAQTFLFRSGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW51</accession>
    <name>A0A231GW51_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780102.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40795">
        <property type="protein sequence ID" value="OXR40795"/>
        <property type="gene ID" value="B7C42_07079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="78" mass="8412" checksum="57E6DE2F081EDB29" modified="2017-10-25" version="1">MSHDHHDDRSDQSSDSGPGGDPPDAAKPGPRRTRADSVEAGWLRPHASPLGRPRLTTVVLLLAWIALLILYLQVRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW63</accession>
    <name>A0A231GW63_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40870">
        <property type="protein sequence ID" value="OXR40870"/>
        <property type="gene ID" value="B7C42_07005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21883" checksum="269F401BD1A1BE20" modified="2017-10-25" version="1">MTAFDELTTLLPPPPARPPVAWDATEAELGVELPAEYKRLYHAYGDVLWCNAFRLLGPAPDEWDDLAARTHRARGDLLPPEQLLPQWQPAVPAGVSIEPAQLIQWGAHEGGDYLLWYPGPDPAVWTIILTNVHQSAWLFTTMPVTDFLLAWTTGTLDLGGNDYFDVAHYLDGEPPYYEIDNPAGDLAGGEPIRVQATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW77</accession>
    <name>A0A231GW77_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator HmrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hmrR_2</name>
        <name evidence="2" type="ORF">B7C42_07109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780138.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40825">
        <property type="protein sequence ID" value="OXR40825"/>
        <property type="gene ID" value="B7C42_07109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="125" mass="13925" checksum="B315CA9AB6BD17F0" modified="2017-10-25" version="1">MLIGELAERAGTSTRMLRYYEQQGLVRSRRSANGYRVYDEHEVDVVRKIRDLLELGFDLADTQPFVTCLRGGNGSGDECPESVESLRRKLAEIDDAIARLGAARRHLTDRIDAVAGPPPKCAFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW86</accession>
    <name>A0A231GW86_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aliphatic sulfonates transport permease protein SsuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ssuC_5</name>
        <name evidence="7" type="ORF">B7C42_07024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40889">
        <property type="protein sequence ID" value="OXR40889"/>
        <property type="gene ID" value="B7C42_07024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="284" mass="30772" checksum="1FB9B541FB0A7889" modified="2017-10-25" version="1">MATTISEPLRDSEAPTDRDLVPPKAPNPWLAKFDRLLYGVIGLGLFLLLWWWVVASGQVSDQYLSTPQDTFRAFVDGLSDGTLGSQIWPSVQRAVIGFVIALVLGVALGILVGSFRIFQKLAEPVLLFFRNLSLLALLPVFVLFFGIGEESKIAIVVWACFWPIFVNAVSAVSGVERLLLNAARTLGAGRFYIFTQVVLPAAFPAIFPGIRLAAANAFTALVAAELVGGAQGIGIYINTASLRYQTPQMYAGIFALGLVGIIVNAILTVVEWRVTSWQRGLTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWA3</accession>
    <name>A0A231GWA3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_13</name>
        <name evidence="4" type="ORF">B7C42_07045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40910">
        <property type="protein sequence ID" value="OXR40910"/>
        <property type="gene ID" value="B7C42_07045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="447" mass="48775" checksum="CD166B726599ACB1" modified="2017-10-25" version="1">MTRELHFFVNVGSSGYHPAAWREDDLPADAFIRLSHYRRTAEIAERGALDGLLFPDIPVQQPSIARAPAATLDPILLTSALAVSTERIGLIPTATTTLNRPYNLARRILSLDRISGGRAGWNVVTTFAPDAARNFGLHDLPEREERYRRAAEYVDLTLRLWDSWEDDAVIGDQAAGRFADPARVHAVDHDGEFYRVAGPLNVPRSPQGRPVLVQAGASGPGRSFAAAWAEAIYTTHLSLAGAQEFATEIRSAATASGRDPDAVRILPGLIPVLGSTEREAQAAFDRLQQRLHPDSDPVRSLAAWLGHPDEVLDLDAPLPPRLLTLPEGRIGPQGFFYSLTRYAAETGYTVRRLLTEFLGGHRVVAGTPDAVADHIEHWFRTGAVDGFTIIPAVLPASLADFVDQVVPLLRARGLFRREYTGTTLRHHLGLAEPSNSFAPALAAADRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWS5</accession>
    <name>A0A231GWS5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_28</name>
        <name evidence="5" type="ORF">B7C42_06850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41080">
        <property type="protein sequence ID" value="OXR41080"/>
        <property type="gene ID" value="B7C42_06850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="21582" checksum="925094BF0C3A9239" modified="2017-10-25" version="1">MNPLPHVSTEDRSIQFIDAAVRVIAERGVASATTRRIAEAADAPLASLHYCFRDKDGLFLAVFEHLAAEITKQFTAIEPAELEATAQEVIRRSVRWLMDHPDYALAEVDLYMWMTRHRPALAKEAYNVFLRAVADVLQRAAGPSARAEAVDNLASVLMGATDGLVLQWASDRDRARADAYADVICAGIPAMCSGIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX15</accession>
    <name>A0A231GX15_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase</fullName>
            <ecNumber evidence="4">1.14.99.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ncsB3_5</name>
        <name evidence="4" type="ORF">B7C42_06742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.49" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41146">
        <property type="protein sequence ID" value="OXR41146"/>
        <property type="gene ID" value="B7C42_06742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="44653" checksum="832837BF398D7FD5" modified="2017-10-25" version="1">MKQEPLVLDLTGADIQAENERIRERGPVALVELPGGVPAWSVTDAVVLKNLLSDPRVSKDPRQHWSAYINGDINESWPLQPWVAAQNMFTAYGTEHRRLRKLVAPAFTHRRTTAMRPRIEAIVADLLERLSATAPGEVVDLRPNYAYPVPIRVISELLGVPDHLDAAIHACVDGFFDTSFTPEQAQANFIEMGRLIGELVSFRRENPGDDITSVLIATRNEDGAQLSETELVDTLMLVINAGHETTLNLIDQAIVALLSHPDQRADVIEGRVPWAELVEETLRYQAPVAHLPLRYAVEDIEVGEIRIPKGEAILASYGAACRDPKVHGETAAEFDVHRANKEHLAFGHGAHHCLGAPLARMEASIALPALFDRFPDLRLAVDPSELNPLGSFISNGHISVPVYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX79</accession>
    <name>A0A231GX79_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821253.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41175">
        <property type="protein sequence ID" value="OXR41175"/>
        <property type="gene ID" value="B7C42_06771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="18807" checksum="9F441826BC7FCA43" modified="2017-10-25" version="1">MATELIKVYTPIKRVPIMIGKAQNGQKLPFGPYTLPQIISGVVVILIASVLAMALPINPAVTFLIGVALTVAVVFGIGLIPYTGVRLTSRVMWVGRLILIRKPVSASGIPVTPDSARHTMYVEESIVVILPDRRADAAEPPPPRTRVLPGNVLDRWSRTLAKVSDNDSVPAGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXU1</accession>
    <name>A0A231GXU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hddC</name>
        <name evidence="2" type="ORF">B7C42_06580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.71" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_062995279.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41437">
        <property type="protein sequence ID" value="OXR41437"/>
        <property type="gene ID" value="B7C42_06580"/>
    </dbReference>
    <dbReference type="GeneID" id="66721222"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="357" mass="37205" checksum="1E50186F8EAD2C14" modified="2017-10-25" version="1">MDTATDAVILVGGQGTRLRPLTLSAPKPMLPVAGLPFLHHLLARIADAGITHVVLGTSFKAEVFEEHFGDGAELGLDLEYVTETEPLGTGGGIRNVLPKLRADNVMVFNGDVLGGADLGAVLDTHASTRADVTLHLVRVGDPRAFGCVPTDETGRVTAFLEKTQDPPTDQINAGCYVFRREYIEKIPSGRPVSVEREVFPSLLAEGAHIQGHVDASYWRDMGTPEDFVRGSADLVRGIAPSPALPGQRGESLVHPGAGVAPGALLIGGTVVGRGAEVGAGARLDGAVLFDGARVEAGATVERSIIGFGARIGPRALVRDAVIGDGASVGARCELLRGARIWPGVDLPDGGIRFSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXX7</accession>
    <name>A0A231GXX7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780390.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41425">
        <property type="protein sequence ID" value="OXR41425"/>
        <property type="gene ID" value="B7C42_06568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="85"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="39274" checksum="985DF1BFE16D7F02" modified="2017-10-25" version="1">MTTTQNPPADLLRPHAEQAYADELRALAAVDDRPRPPSWRLSPWAVVTYLLGDTLSDGTVITPKYVGPRRLMEVAVATLATDRALLLLGVPGTAKTWVSEHLSAAVSGASTLLVQGTSGTAEEAIRYGWNYARLLAEGPSDGALVPSPVMTAMRTGAIARVEELTRIPSDVQDALITVLSEKTLPVPELGIEVQAAKGFNVIATANDRDRGVNELSSALRRRFNTVVLPLPAGEDDEVAIVTRRVEQLGAALQLPPIPAAAEEVRRVVRVFRELRSGITEDGRTKLKSPSGTLSTAEAISVLTNGIALAAHFGDGVLRASDVAGAVLGAVIKDPVADAVVWTEYLEAVVRERPEWSDFYRACREVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY31</accession>
    <name>A0A231GY31_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41498">
        <property type="protein sequence ID" value="OXR41498"/>
        <property type="gene ID" value="B7C42_06390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="22199" checksum="54049C29DA5B61B3" modified="2017-10-25" version="1">MSTAVDEQDTPAAPETDKDENNSATTASVPSGERRAALTIAVRLSTVLTTAVIVALLVVSIVFGCLYFSARSTLSDRDTAAAADRHAADIASKYAVGASTIDYHDVKSWIERLKAGTTTQLAAKFDATAPQLEQILLPLQWTSKATPLSAAVTSESDGIYKVDAYLDVTSTSAQTPDGGRTTVTYSLTIDRNADWKITDVGGLQNALPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYL1</accession>
    <name>A0A231GYL1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma F factor</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIAB</name>
        <name evidence="3" type="ORF">B7C42_06306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41665">
        <property type="protein sequence ID" value="OXR41665"/>
        <property type="gene ID" value="B7C42_06306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="170" mass="18714" checksum="358A4EF84D6D4E83" modified="2017-10-25" version="1">MRHPENPRHPDSRAQKAATTSGQRSLEDLHIEFRARSEELQRVRTLLRAWLAGTNLGPDRAYDLLLAVNEACTNAVEHGHRGDGRTVVLHATATHSIRITVSDSGTWRTPRADEEVDRGRGLPMMNALMPGTRVVSGADGTTVEFVASPTTEERSPDTGQRSRRSSAEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYT0</accession>
    <name>A0A231GYT0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intracellular chorismate mutase</fullName>
            <ecNumber evidence="3">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505489.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41735">
        <property type="protein sequence ID" value="OXR41735"/>
        <property type="gene ID" value="B7C42_06077"/>
    </dbReference>
    <dbReference type="GeneID" id="66723136"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010958">
        <property type="entry name" value="Chorismate_mutase_highGC-bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01808">
        <property type="entry name" value="CM_M_hiGC-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="102" mass="11331" checksum="F37D7F30466B95FD" modified="2017-10-25" version="1">MSTSTEPIDQPATGSDATLPSSEAEIEKLRKEIDRLDAEILAAIKRRTEVSRIIGRTRMANGGPRLVHSREMKVLERFSELGQEGHTLAMLLLRLGRGRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ60</accession>
    <name>A0A231GZ60_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tauD_3</name>
        <name evidence="5" type="ORF">B7C42_06153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.17" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41811">
        <property type="protein sequence ID" value="OXR41811"/>
        <property type="gene ID" value="B7C42_06153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000908">
        <property type="term" value="F:taurine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="33734" checksum="D0A883398BDF8E3E" modified="2017-10-25" version="1">MTSIAPVRLSARSAPFGVRPLTCTIGAELFDLDLAEVARDDTLFAALKDLLLEHKVLFFRNQNISRAEHVALAQRFGPLEDHPVLGSDPEHPGLVRIYKDLDSAPEHYENAFHCDATWRAAPPMGCVLRCVETPAVGGDTIWVNMAEAYRRLPESVRSRIAGLRARHSIEASFGAMRPDAERLRLHEQFPDAEHPVVRTHPETGEKVLFVNAFTTHFVNYHTPENVRFGIDYAPGASELLNYLVRQASVPEYQVRWRWTENSFAIWDNRCTQHYAVQDYFPDVRKMERAGIIGDKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ89</accession>
    <name>A0A231GZ89_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_25</name>
        <name evidence="1" type="ORF">B7C42_05892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41908">
        <property type="protein sequence ID" value="OXR41908"/>
        <property type="gene ID" value="B7C42_05892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="27209" checksum="C959239151927917" modified="2017-10-25" version="1">MDTADHCGGSVLDLFRLTDRVAVVTGAGTGLGAGFARALAEAGADVVVAARRRDKLENVADSVTALGRRCLVVPTDVTDPDQCDDLARAAIDTFGRVDILVNNAGVTHAAPATREDPDDYRKVLEVNLFGAYWAARSCARVMRPGSSIVNVSSMLGLVKSVLPQAAYASSKAGLIGLTRDLSHQWSGRKGIRVNAIAPGFVDTDMIGEMADSTLSEFLRNCSLGRTATQREIDAAVVFLAGPASGYITGSTLAVDGGTSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZG2</accession>
    <name>A0A231GZG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42004">
        <property type="protein sequence ID" value="OXR42004"/>
        <property type="gene ID" value="B7C42_05988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="24013" checksum="6A4C6D9BB1C5D6F1" modified="2017-10-25" version="1">MSKFPMLEHRDTQPDTDGVRRNDKRPRAIGLIRPGVSGADASRHALAIERHAERLGYHYVYTVRPPEDRPDPVGYGLAIALGVDAAAVVVYDLTTVDHSPARVCDWCDLETVCPPETWARSPIAPEHAGPPHPLTEAIARRIMQQHKGCRAHRCPRKAAAFGFLVQAGKIVPPVHTLRERAAARGIRVDPIGSELPVTTGADLGTLLSVLDGLVADMRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZK4</accession>
    <name>A0A231GZK4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator SlyA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">slyA_5</name>
        <name evidence="2" type="ORF">B7C42_06031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782289.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42047">
        <property type="protein sequence ID" value="OXR42047"/>
        <property type="gene ID" value="B7C42_06031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15383" checksum="ABC9018494C329A3" modified="2017-10-25" version="1">MSDDPLAPSPDEVWRVLTDVVKDTRDTWKRAVVDRTGMPFSRFRVLRRLAPGPLPLKELARVATMDAPATTVVVNDLEARGLVSRDTAADDRRRKLVTITDAGREVLAQAMATPDPPPPALTALSPEQLRTLHDLLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZZ4</accession>
    <name>A0A231GZZ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe/S biogenesis protein NfuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nfuA</name>
        <name evidence="5" type="ORF">B7C42_05769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42170">
        <property type="protein sequence ID" value="OXR42170"/>
        <property type="gene ID" value="B7C42_05769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="25944" checksum="B4C0688F1F17956F" modified="2017-10-25" version="1">MVDLYGAGLRRILAVLDEATVQRLLADDLVASLLLVHGLHPHDVATRVAGALDSVRPYLGSHGGDVRLLEVTAEAVVRLELTGSCRSCPSSSVTLELAVEDAVRAAAPEITAIEVIAAEAAADSAVFAPETLFAHVRSGGNWIGAPELADLAAGEVGGFALGGLTVLACRVGDEIYVYRDHCPNCDRTLAGAVLHRGIDGDPVLRCPGCRAHFDVVHHGARLDGGGHLEPLPVLVRDGELSVAIPVEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H029</accession>
    <name>A0A231H029_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782817.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42091">
        <property type="protein sequence ID" value="OXR42091"/>
        <property type="gene ID" value="B7C42_05690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011223124" evidence="2">
        <location>
            <begin position="30"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="23426" checksum="24E4EC0274A09879" modified="2017-10-25" version="1">MRKTIVTSALLAAAISVSCATASADAGHAATPIGYTATLTPNTAVIETDSAGTISTDHGVLTIRPKEGGPVLAGAELSFRVDDFVFPIAADIHGNRAVLTPQFDVRHAVYRPVALPFENQAPWKNEYDREQAAWSRLSSTILTGATIGTLVGGLGGAAVGCVLGGIAGATVAAAAIIGLFGGFLPAAAIGCLGGIVAIGALGTAAGQLFVTAPIAIMAAVQYFTTVNQPAPSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0A6</accession>
    <name>A0A231H0A6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42277">
        <property type="protein sequence ID" value="OXR42277"/>
        <property type="gene ID" value="B7C42_05476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="295" mass="31614" checksum="1FC44F80249757BB" modified="2017-10-25" version="1">MLYVAATQRERSDVPASHLSIVPSVPGIPAGAAVLIAVACTFIGFFIDSGNSGKELTHVFAAFYIIGCVIAACVVRYRGLFTTMVTPPLLLFIAVPLAYQQLIGHSSTSVKDILLNLAIPLVNRFPTMALATVLVLGVGAVRVWLYRNADSTARPTRERGGDSWNPRSAAGRARRARSEAAGGETLRRSSRGQKRGAEATKSAKAPKRGDSAARGSGAAKRAAEPEPARAARRTGGKVAERPPRVAAAASYPRTGERTRTAERTRVAEPQPRRGRPQPPSDVPPHPRPNVRYRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0E2</accession>
    <name>A0A231H0E2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42354">
        <property type="protein sequence ID" value="OXR42354"/>
        <property type="gene ID" value="B7C42_05553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22178" checksum="9AA55C9716F27CBB" modified="2017-10-25" version="1">MATTAQLRAALAVLHADTDEAAEQARISEMSGTDSAGVEHALLAGLLYRMMGDDLRHSLTGAPDLTALEERARAAGPGTVTDATDDREHREEQCAQAHFEAYWLAHRIAGLHFTTVPSAPALQAAAHTAEATRTLLRIHRDLLHAPDAGHPAWEVVIDQLDRARELAQAAYAGTRPSDPQPSDAWPSDAGAGVPETGRERSTECRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0F6</accession>
    <name>A0A231H0F6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rd</name>
        <name evidence="10" type="ORF">B7C42_05850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="7 8">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the rubredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779734.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42251">
        <property type="protein sequence ID" value="OXR42251"/>
        <property type="gene ID" value="B7C42_05850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="9">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="60" mass="6469" checksum="AF4DE9EE1C486B83" modified="2017-10-25" version="1">MTTATTTQLWICTRCGMIYDPAEGDPDGGIAPGTAFADIPDDWVCPVCGARKVDFIPYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0R0</accession>
    <name>A0A231H0R0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pmt</name>
        <name evidence="16" type="ORF">B7C42_05633</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043139.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42432">
        <property type="protein sequence ID" value="OXR42432"/>
        <property type="gene ID" value="B7C42_05633"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="14">
        <location>
            <begin position="43"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="15">
        <location>
            <begin position="349"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR42432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="553" mass="60587" checksum="3ABD78FB269762D8" modified="2017-10-25" version="1">MTQLTDTRPAIGAGPALSSPAPLRPAPDFGPTDRARGWLVTLFLTVVAAVTRFTMLNYPTDAGTPVFDEKHYAPQAWQMLTGGGVEDNPAYGLVVHPPVGKQMIALGEALFGYTSWGWRFTAAIFGSLLVLLVIRITRRMTRSTLIGAIAGVLLIADGVTFVSSRIGMLDIFQAVFVVGAFGCLIVDRDEVRARLARADAEGRIAPAARATGPEAAARVTTEGTGSAALAFSAFGPRLGVRWWRFGAGLLLGLSCGTKWSGLYFILFFGLMTVCFDVAARKAYGVPRPWAGTAVRDIGPALYALVAIPLLVYLASYWGWFASEDGYDRYSVGNAVGTGGTWSWIPDALRSLWHNQAESLKFHQSLTNSAGNHHPWESKPWSWPMGLRPMLYYYADNGVTGCGQAVCVKAVMLIGTPAMWWLSLPMLAWALWRTATRRDWRYAAMLVGYGAGLLPWFADLDRQMYYFYAVPMAPFLAMGLALTLGDILGPAPLVRARSGRWFALAGERRSLGLLLVCLYLGLVIANFIWLWPILTALPITPSNWHDHLWLPSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H178</accession>
    <name>A0A231H178_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">META domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42592">
        <property type="protein sequence ID" value="OXR42592"/>
        <property type="gene ID" value="B7C42_05369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601728" description="META domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="14599" checksum="6BDE793BD6FA1AC4" modified="2017-10-25" version="1">MSANILRIAPLLAVLVAGVACSSGNDSAPTDSTPATPVGHTYISTDVQGPRIPGDGPLRLTFTAGRLSATAGCNTLMGSADLAGNTLHTGPLAATRMACVGDRAGADEWATSLLQASPTWSLDGATLTLKTADRTVTLHESEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1G2</accession>
    <name>A0A231H1G2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgP</name>
        <name evidence="12" type="ORF">B7C42_05025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42689">
        <property type="protein sequence ID" value="OXR42689"/>
        <property type="gene ID" value="B7C42_05025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR42689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="894" mass="97954" checksum="340FB69A6BD21A39" modified="2017-10-25" version="1">MLPCRVYPVKALRRFTVRAHLPQRLAALGELAANLRWSWHGPTQDVFAQLDPELWVRVGRDPVRMLGEVDADRLDEWAADPGYQAAVDAAEADLRDYLTRPRWFGEHIAAEPESPAPRGIAYFSMEFGVTEVLPNYSGGLGILAGDHLKAASDLGLPLIGVGLLYRSGYFRQSLTADGWQAERYPDLDPQGLPLRLLAEEGAPVLVHVPMPEGRVLRARVWIAQVGRIPLLLLDSDIGDNDPELRAVTDRLYGGDQDHRIKQEILAGIGGVRAVRAYTRARGLPDPDVWHMNEGHAGFLGIERIREYMAGGMDFDSALAAVRAATVFTTHTPVPAGIDRFAAGLVRRYFGGAHGERESPLLPGISVDRILALGREADPSVFNMAHLGLRLAQRANGVSRLHGEVSRDMFAPLWPGFDAAEVPIGSVTNGVHAPTWAAREWIGIAARATGPEEAASVTTEGPGSAAVDTAHDPVGPELVAEGRGWEQLRAVDVRELWETRATLRAVLVAEVRRRLRESWLERGAAPAELGWVDEVFDPGVLTVGFARRVPTYKRLTLMLRDPDRLRALLLDPERPLQLVVAGKSHPADDGGKALIQQVVRFADDPAVRHRIVFLPDYDMSMARYLYWGCDVWLNNPLRPLEACGTSGMKAALNGGLNLSIRDGWWDEMYDGDNGWAIPTADGVRDEHRRDDLEAAALYEMLQRSVLPRFYERDESGLPVRWMEMVRHTLRTLGPKVLASRMVRDYTTGYYLPAAGSYAAVAAGDFAGARALAEYRRRLESVWSQVKVLQVDSSGLPDIPVIGAELSLRARIDLAGLSTGDVVVQAVLGRVGSDDELTDTEVVDMDHLSTDAGTEQYAVTTPVPHSGAVGYTVRVLPRHPLLSGPAELGLVAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Q3</accession>
    <name>A0A231H1Q3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 16U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yceD</name>
        <name evidence="2" type="ORF">B7C42_05109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42771">
        <property type="protein sequence ID" value="OXR42771"/>
        <property type="gene ID" value="B7C42_05109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="20583" checksum="0CCACFAF94561696" modified="2017-10-25" version="1">MRTDVAPLGGEVRLMSGDQPRGAAGPVEFATVGLGWDPAHGRRWFGARRTAIDLNAAAVLLAGDNPVEVVYHQQLISADGAVRLLGDSVNGEDEGDDEIITVDLTRVRPEITAVAVVVTCYSGQTFADIDNARCRVTGADGTVLADRELGAGGDTGMVVGVFRRERDGWEFREIAAGITAAHPVEALPHLAGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Y6</accession>
    <name>A0A231H1Y6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase LipV</fullName>
            <ecNumber evidence="2">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lipV</name>
        <name evidence="2" type="ORF">B7C42_05202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42864">
        <property type="protein sequence ID" value="OXR42864"/>
        <property type="gene ID" value="B7C42_05202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="27087" checksum="E254EA60064645E8" modified="2017-10-25" version="1">MSDAPIHRFGPADGPLVLALHGLTGHGRRWSALAEGQLPEVRVVAPDLRGHGRASSLPPWTFEQIVDDLVPLLTEPAVVVAHSFGAAVAVHLSRHRPDLVRALVLLDPAIGLDPVLLHDIAEAGLARPDYADIAEARHDKLETAWADVDPELLDAELAEHLVDTPEGRVTWRMSLPAVTSYWSQLARELVLPPPHIPTVLVRAGKSPFVTPATVEAFATLPDFTLHEFDCDHMVAQARPAETAAVVRSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H256</accession>
    <name>A0A231H256_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778365.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42928">
        <property type="protein sequence ID" value="OXR42928"/>
        <property type="gene ID" value="B7C42_04814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="33742" checksum="6D6C2A90EB0429EC" modified="2017-10-25" version="1">MGNDATLLPRDTFAQRLLLGSVRKSYDPVVDLDWDAPLDPDKFFLPPEVVSLYGTDLWDAMSPEQRRELSRQELANILSVGIWFENILNRLLLRELMNGDPTSHRSHYTLTEMGDECRHMTMFGKLIDRIDARPYWPKTPARLAISSLQLLLHGPMVWVGALVGEEIFDALQRRTIDDPQLQPVVARTFRVHVTEEARHIGFARDALARRVPAMSRAERAYVRMCVAVAAPLFVRLITNRHMYIRAGLDGRAAVRAALANPHAHRMLAAGGADLGAFLDENGLLGPIGKRLWRRRGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2F4</accession>
    <name>A0A231H2F4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43030">
        <property type="protein sequence ID" value="OXR43030"/>
        <property type="gene ID" value="B7C42_04916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7770" checksum="D2A1000E680CDB5F" modified="2017-10-25" version="1">MSATVVPLVPRSGFTVRRSGETWELINSRHYGRGVVLHSWARDGHSEAFEHCYRLNGRSIEELLAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2J8</accession>
    <name>A0A231H2J8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43080">
        <property type="protein sequence ID" value="OXR43080"/>
        <property type="gene ID" value="B7C42_04966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="22222" checksum="193670226FD181AB" modified="2017-10-25" version="1">MVTPMLSRHAERPLTPDNWIHAQVLVLNASYEALTDIGADRAVVLVISGTAETVAERQPHFPIRSKHLEIALPQTIRLLRYVYLEHSVLVHDESRATLAGVLRRDDHRCGYCAGWARTVDHIRPRSRGGPNTWNNLIAACGPCNTRKADRTPDEAGMRLLWEPKAPTDMQRRQRRIWKDLIAGGAQRTATGAQRTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2P9</accession>
    <name>A0A231H2P9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43125">
        <property type="protein sequence ID" value="OXR43125"/>
        <property type="gene ID" value="B7C42_05011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="128" mass="13542" checksum="1ADCE901824A9ED5" modified="2017-10-25" version="1">MAGATSTPADMAVLAVFLRAAAARHCVLGLVGTARVDAAERLWALATRRLPDPDRAHVAAQLAFSANRRGDVVLASIALEAALNSNPQHRFAQSLNTALELGTSPLRLQAVVNYAYDIAAALGLYLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2X0</accession>
    <name>A0A231H2X0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadA_9</name>
        <name evidence="6" type="ORF">B7C42_04570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43148">
        <property type="protein sequence ID" value="OXR43148"/>
        <property type="gene ID" value="B7C42_04570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="280"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="41882" checksum="CBFA82E5EEE05968" modified="2017-10-25" version="1">MPNQAIVYEAIRTPRGKGKNGSLHSIKPIDLVVGLIDELRARFPDLDPAHIDDLVLGVVTPVSDQGGNIAKAAALTAGLPETVAGLQINRFCASGLEATNLAAQKVGSGFESLVLAGGVESMSRVPIGTDGGPLFNDPATAYDLHFVPQGIGADLIATIEGFSRADVDAYAVRSQQRAENAWSGGYFTKSVVPVKDFNGVTVLDHDEHRRPGTTVESLAALKPSFAALGAAGFDAVALQKYSSVERINHVHHGGNSSGIVDGAALVLIGNEEAGKQFGLTPRARIVATAVSGADPTIMLTGPRPATEKVLAKAGLSLDDIDLFELNEAFASVVLKFQKDLHIPDEKLNVNGGAIAMGHPLGATGAMLVGTVIDELERRGERRALVTLCVGGGIGIATIIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H309</accession>
    <name>A0A231H309_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43234">
        <property type="protein sequence ID" value="OXR43234"/>
        <property type="gene ID" value="B7C42_04656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8463" checksum="2D13EDD8F521BD8E" modified="2017-10-25" version="1">MAVLANEFAAARISLDTSGNGPRLLVEDLDSGARIFLSPLELACFCLATSEDRDNWLRVGTYRDERSPHRAPVGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H332</accession>
    <name>A0A231H332_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43206">
        <property type="protein sequence ID" value="OXR43206"/>
        <property type="gene ID" value="B7C42_04628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18710" checksum="F5D938973493F3DA" modified="2017-10-25" version="1">MTQLGSEIDTAFRHFYSTGPIHGDWASWADSFTADAKYHDPHRGAAVGPEAIRELVESSLVGSIPVYSPLVWYAADGDRVAFRSVHRADRPDGGRIAAEFTSTTILTYAGDGRWSGMDCWWLLPERKKFVREYLGAREQPGPVPEPAAPRDWGPWIDWARPVPDARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3H2</accession>
    <name>A0A231H3H2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">bicA</name>
        <name evidence="14" type="ORF">B7C42_04320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43453">
        <property type="protein sequence ID" value="OXR43453"/>
        <property type="gene ID" value="B7C42_04320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="13">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR43453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="736" mass="76813" checksum="E8E5BBDFB20CF3A9" modified="2017-10-25" version="1">MSTDTDSVRRTSPRGLSVVLRHDLPASVVVFLVALPLSIGVAVAMGAPVAAGLIAAVVGGLVAGLCGGSVLQVSGPTASLTVVVAESIHQFGWATTCFITVCAGALQVVFGLSRIARGALAIAPVVVHAMLAGIGVVIALQQLHVLLGGQTLSSSWASIVQLPHQLTVMHAGDALVGGVVIAIMLGWRYLPGRIRAVPAPLAAVVAATALAMVVPTSVERITLHGSLFDAMSLPQLPHGHWSAVVLTAFTIALIASVETLLSAVAVDRLRPEYRTDLDRELLGQGVANMTSGMLGGLPIAAVIVRSITNAKAGARTKASTMLSGVWVLVFSVALVEVVRQIPKAALAGLLIVIGIGLVKLAHIRLARRAGDLIVYAATVLVVIFGNLLLGMLIGLVLSFALLMWRVVQVVIVAAPVGDTGRWLVTVDGSATFLALPRLTAQLARIPAGVPVTVEMTVDFIDHAASDTLHEWAQRHESLGGAVQFVELGAVRIADLTAGPPARGHARRMLDDVLAPWRPTTRTDRIAAGIAAYHRGHAHMMRPHLDELRHTQDPESLFVTCADSRIVPNVITNSGPGDLFTVRNIGNLIPADGRDTSVEAALIYALNKLDVRSIVVCGHSGCGAMDALHHGLHTGSGLDDWLAHGRPALERFRAGHPVAVAAAAAGYGEVDQLGMVNVAVQIETLAAHPVVRRGIEARGVVLSGLFFDIATARVLAITPDGIADIDDLRHPVPVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3J0</accession>
    <name>A0A231H3J0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43352">
        <property type="protein sequence ID" value="OXR43352"/>
        <property type="gene ID" value="B7C42_04775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="30678" checksum="1B044FD41CD629FA" modified="2017-10-25" version="1">MTTTPDSPDARQPPDVPRLAGGVPVGIPALGPWLRVMREHRDLTRELAGQYTHVSATYLKSVEVGSATPRRDTLDKIITGYELSPAQRRHTIDLWEPAAVLAPLDELRERIATPARRGELATWDARAIACGFCDPLWNVVAANQQFQSLFPALDQAENNLAIWRFSSADESCRQGAEEDAQFFVATLRAALGRFRDAPEGARLLRQLAGSARFAGLWRSGVEVAYDIGPSPRRWGDREELVTVQVTELVEEPGVRLFLAYRTRAAGHQGADDVGAQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3S6</accession>
    <name>A0A231H3S6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_A24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43539">
        <property type="protein sequence ID" value="OXR43539"/>
        <property type="gene ID" value="B7C42_04407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="15932" checksum="67073123051827E5" modified="2017-10-25" version="1">MAAMTTAAYLALIVWCVALSVIDIRTGRLPDVLTLPGAAIVPVLAASTGRATAAIAGALLLAVPYLLTHLIDPAACGAGDVKLALGTGAAAACGGPSCWVWAAIGAPLLTASAGVGVLVATAVAARAATGDPDRRRGLFGASITVPHGPAMCLATVAALWPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3U8</accession>
    <name>A0A231H3U8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppiB_1</name>
        <name evidence="5" type="ORF">B7C42_04378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43511">
        <property type="protein sequence ID" value="OXR43511"/>
        <property type="gene ID" value="B7C42_04378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="30172" checksum="25507148A66FEF21" modified="2017-10-25" version="1">MPTNEQRRAAAKRKLERRLERQAQRARKRKQLAIAGSALGVVVVVAAGVGIYYLTRGDDTPNAAAKTPDASLSSTPQAAAPPEAKPKTATVSCAYTDGGQAAKPVHKPEQTEVSTTGSPKVAIDTNRGPIGISLNAGESPCTVNSFVSLVQQKFYDGTPCHRLTTGEGLKVLQCGDPSGQGNGGPGYAFPNEYPTDQFAPGDPNAQRVPVQYKRGVVAMANSGPDTNGSQFFLVYGDSQLPPQYTIFGTVDEAGLKTLDAIAKDGVEDPSTGDGAPKQPVTVKTMQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3W5</accession>
    <name>A0A231H3W5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779192.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43550">
        <property type="protein sequence ID" value="OXR43550"/>
        <property type="gene ID" value="B7C42_04418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="27318" checksum="F14DB80A2A2E9707" modified="2017-10-25" version="1">MESIGAGILAAMPLHTLSDVHGEEGLRQRLLLESQRKLADPERVDAALEFVADLHRDDNYGREPYLNHLLRVAIRIVSHYEVHDTDLVLAGLLHDAVEDHADDLVALRDEHDPGADSAAAALAVLTRRFGERVSNLVAAVTNPAHDSDEDRHIRYRDHVAASLDRDPWARVVKISDFTDNGVGILYADEQAVMSKLATKYRPLTAVYRELITRPDTPLAPHVKQHILEQLDTADARFDVILAAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3W8</accession>
    <name>A0A231H3W8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">alaS</name>
        <name evidence="12" type="ORF">B7C42_04399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779210.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43531">
        <property type="protein sequence ID" value="OXR43531"/>
        <property type="gene ID" value="B7C42_04399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="11">
        <location>
            <begin position="1"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR43531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="888" mass="95528" checksum="3DAE929E76AEE0A5" modified="2017-10-25" version="1">MQTHEIRRRFLDHFVRAGHTEVPSASLILPDPNLLFVNAGMVQFKPYFLGQEAPPFARATSVQKCVRTGDIEEVGVTTRHNTFFQMAGNFSFGDYFKEGAITFAWELISKSQEEGGFGFDPERIWVTAYESDPEAAEIWHRVAGIPKERIQFRDGKDNYWDMGVPGPGGPCSEIYYDRGPEYGAEGGPVADEDRYLEIWNLVFMQDIRGEQSPKLGYPPVGSLPKKNIDTGMGIERVAMLLQGVDNVYETDLLRPIISKAEELTGKSYGVEHADDVRFRVIADHARTSAMLIADGVNPGNDGRGYVLRRLLRRIVRSARLLGAEKPVIGEFMKVVSDLMSPSYPELATDFTRIETVAVGEETAFLKTLSTGSKLFDDAVAEVKATGGRTLAGSEAFTLHDTYGFPIDLTLEMAAEAGLEVDESGFRTLMAEQRQRAKDDAQARKHAHADLSIYKELVDRGATEFTGFDELATEARVLALIADGVRVPTATAGQDVEVILDRSPLYAESGGQIADRGSLTASGTELRVNDVQKIAKKLWVHKTTVERGQITEGDAVLAQVDPAWRRGATQGHSGTHMVHAALRQVLGPNAVQAGSLNKPGYLRFDFNWQGQLSESQKADIEAVSNDAVGSDFPVNTFVTDLPKAKAMGALALFGENYGSEVRVVEIGGPFSMELCGGTHVEHSSQIGPITLLGESSVGSGVRRVEAFVGLDSYKYLAKERALLAGVAASLKVPSEDVPARVEQLVERLKVAEKELERTKAAAVLSQAGTYVEQAQRVGKVLLVAAAAPKGVGAGDLRTLATDIRGRFGSEPAVVVLLGNADGKVPFVVAVNKPAQELGVKAGDLVGSFGPSIAGRGGGKPEMAQGAGSDPSGIEAGLAGVRARVAEIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4K4</accession>
    <name>A0A231H4K4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylglucosamine repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagC_3</name>
        <name evidence="1" type="ORF">B7C42_03995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781200.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43760">
        <property type="protein sequence ID" value="OXR43760"/>
        <property type="gene ID" value="B7C42_03995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="31923" checksum="D36C7E3FF0B0907A" modified="2017-10-25" version="1">MAVLAVDIGATKFAAAVAISPIGAVPGDESTAARPAALRHIHQVGVPPRDVWETCRELLRRVVGAASADEACGGADFEVTVVGIAAAGPVDVRTGSTAPLNIPEWRDGFPIVAAVRELFPAADIRFVIDGAALALAEYRVGGLRGVRSGLAMTVSSGIGGGIISDGRVVSGRTGNAGHVGHIVVPGWDVPCACGGAGCVEAVASGMSSVRWAREQGWPGTTGLDLARAAEAGDPIALAALSRAGTALGQAISSAAATLDIDRVVIGGGFAESGGPLWEPLRAAVARHARLGFIRELEILKSPITDGATLVGAAALASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Q7</accession>
    <name>A0A231H4Q7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43879">
        <property type="protein sequence ID" value="OXR43879"/>
        <property type="gene ID" value="B7C42_04118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22524" checksum="824B7DE563D30C10" modified="2017-10-25" version="1">MPGRKYQGLMPDERREQRRAAILDAALEVFGTGGYAGSSVKQICRAARLTERYFYESFTDRESCLAALYSEVVTRVRAATVAAMTSAGDDIDAQTRAGLQTFIGYLTEDRRLARVALIEAVGVSPAMEERRHEVLREFAEIVTAAWAATRAEPLSPQQHSAAVALVGGVNHLLVDWLMGGSPQSPAALTDVCSTLFIAARRTFEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H552</accession>
    <name>A0A231H552_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44029">
        <property type="protein sequence ID" value="OXR44029"/>
        <property type="gene ID" value="B7C42_03585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="15894" checksum="8C8826BDB5F94482" modified="2017-10-25" version="1">MNQPLVALLRGISASIVDELVTNVHAAGYPDITAAHHPVFYNIDWEGTRLTTLAARAGITHQSMGELVADLVDLGYLARQPDPSDRRARLIVLTEKGERAVRAARAAVSDIDRAWYARLEAAGIQGDLRTALGAALRQARGDLQISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H553</accession>
    <name>A0A231H553_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">B7C42_04091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43856">
        <property type="protein sequence ID" value="OXR43856"/>
        <property type="gene ID" value="B7C42_04091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="70"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR43856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="31413" checksum="2E0B044D6760A23B" modified="2017-10-25" version="1">MHGYANGLKTFGLMVGLSALIVFAGAMFRNPTILIIAILLAVGMNAYAYFSSDKLALRAMHAQPVSELEAPVMYKIVRELATTARQPMPRLYISPTNAPNAFATGRNPRHAAVCCTSGILQILDERELRAVLGHELSHVYNRDILISSVAGALAAVISGLANLAFFASMFGGGGSSRDGEGPNILGVLLVSLLGPIAATLIKLAVSRSREYQADQDGAELTGDPLALASALRKLERGTQAAPLPPEPQLTAQSHLMIANPFRAGDKMARWFSTHPPMGERIQRLEHMAGGPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H673</accession>
    <name>A0A231H673_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782875.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44351">
        <property type="protein sequence ID" value="OXR44351"/>
        <property type="gene ID" value="B7C42_03912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14345" checksum="1BDA015E446325A1" modified="2017-10-25" version="1">MTAITASAPSVTTTRPGRIRNRVLWTLQIVLGLFFVIASGLPKVVGQSDAVRIFHDIGWGDWFRYFTGLVEISGGIGLLVPRLSWLAAAGLSITMVCAAATQAFVMDAPAGAIFPLVLMAVFAWIAYERRPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H696</accession>
    <name>A0A231H696_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative non-heme bromoperoxidase BpoC</fullName>
            <ecNumber evidence="2">1.11.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bpoC_1</name>
        <name evidence="2" type="ORF">B7C42_03223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.18" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44434">
        <property type="protein sequence ID" value="OXR44434"/>
        <property type="gene ID" value="B7C42_03223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019806">
        <property type="term" value="F:bromide peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="28169" checksum="BE8B4705C909E87A" modified="2017-10-25" version="1">MARHVSSVPMLYDEGGTGVPILLLHGLMGSARTWAGQVPWLRAFGHVHSFDAAGHGRPAPPELTTEAFVADLAAATAAISEPMVVIGHSMGGLHGWMFAATHPERVRALVIEDMAPDFRGRTARHWAEMIEAWPQPFPDADAVLDYFGPVAGRYFLESFTRAPDGYRLHGSVATFRDISEEWGTRDFWSEWAAVRAPTLLIEGEYTITPPGQMREMAAARPSVRHVVVGAAGHLVHDDQPDVYRAEVERFLHENLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6B4</accession>
    <name>A0A231H6B4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44388">
        <property type="protein sequence ID" value="OXR44388"/>
        <property type="gene ID" value="B7C42_03177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041586">
        <property type="entry name" value="PsrA_TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17939">
        <property type="entry name" value="TetR_C_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C_30" evidence="4">
        <location>
            <begin position="91"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="23229" checksum="E461B2B4DCD14AF3" modified="2017-10-25" version="1">MLRVEAVSARERLMMAGERLIAERGYLVPLRDIAAAAGQRNNSAIPYHFGSRDGLVEAVVQQRLATLEVRRLELLAQRPAAAADDVHTLLDALVIPMFELGASDENSYYARFLEQIRTHPAVSDAANLDSAERTSVRVIVSGLDRALSDLPPRLRHRRLRSLTTVLFALLADHERAVEAGRIAADDREAWDQVIDMLAGTLTAPVTTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6E4</accession>
    <name>A0A231H6E4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44360">
        <property type="protein sequence ID" value="OXR44360"/>
        <property type="gene ID" value="B7C42_03148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="26985" checksum="0C1029669A8888EB" modified="2017-10-25" version="1">MTVSLLCGAGALLLLPTPTRRHRLRALYGLPKGNRNIPSRWIIRGVTATAVVAAVVFGPGVAGAAAVLATTLTVRAKNRREERRHDGECRKLLEGLEVVIGELRTGAHPSAAAAVAAEEIGGAAGAAFAVSAARARLGGSAADGLRGRRCAVTTELDRVANAWEVAERHGLALAELLSAARDDLAGRMRFSDRTTAALAGARASAAVLAGLPLLGIALGQLMGAHPLQVLMSRGVGTIVFPLGAGLIGVGLLWADAITRRVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6I6</accession>
    <name>A0A231H6I6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator GltC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gltC_3</name>
        <name evidence="3" type="ORF">B7C42_03323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44534">
        <property type="protein sequence ID" value="OXR44534"/>
        <property type="gene ID" value="B7C42_03323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="32032" checksum="F7CADABDA2AF5E9C" modified="2017-10-25" version="1">MQYFLTVAEELHFGRAAERLHIVQSAVSQQITRLERELGVALFERTTRTVRLTEGGRRLLPHAEQVLAAVTQARAAIDDLRVERTGTIRLGTSTGLGTRLENILVAFAHRAPHAHLELVDADTEIRMKRVRSGELDAAIVRGPRDEPGLELLPLWSDRLVAAIPARHDLAVLREIDLARLARLPLRLVGRTRNPTLYDLVVDSCREAGFAPAFGPEFTTEQDTLAAIGFGAPSWTVYYATQAANLSFPGVVWRPLRNPEPRMPSYLAVPPDPPRAELRALIEACHAVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6J0</accession>
    <name>A0A231H6J0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497539.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44465">
        <property type="protein sequence ID" value="OXR44465"/>
        <property type="gene ID" value="B7C42_03254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="42"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="236"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="35376" checksum="62C7580EC3BCAF4C" modified="2017-10-25" version="1">MTTPLDVTIKRTDAVLREIARAVVGKREELQLIMIAVLSGGHVLIEDLPGLGKTLIARSFATALGLDFTRVQFTPDLLPADLIGSTIYDMASGRFNFRRGPVFTNMLLADEINRTPPKTQAALLEAMAEGQVSIDGETFPLPQPFIVLATDNPIEYEGTYPLPEAQLDRFAMQLRLGYLSEKDETQMIRRRLERGAVTPQVGQVVDAQGLVEMRQAVEFVTVHPDVVTYVVALAAATRGHPQVEVGASPRAELDLVQMARARALLLGRDYVIPEDVKALAVPAMAHRITLRPEMWVRRIRGEDVISELLRRLPVPRATVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6L2</accession>
    <name>A0A231H6L2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin OsmC</fullName>
            <ecNumber evidence="1">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">osmC</name>
        <name evidence="1" type="ORF">B7C42_03221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775731.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44432">
        <property type="protein sequence ID" value="OXR44432"/>
        <property type="gene ID" value="B7C42_03221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019904">
        <property type="entry name" value="Peroxiredoxin_OsmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03562">
        <property type="entry name" value="osmo_induc_OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="14671" checksum="4571F0E131EED516" modified="2017-10-25" version="1">MPTRSARTAWTGGLQDGSGQVDLASSGVGKFDVSFPKRTADTAEGTTSPEELIAAAHSSCYAMALSGQIGAAGGTIESLDVNADVTLGPDPAGGFRISKIALTVRGRVSGIDASGFEQAAQTAKAGCPVSKALAGVETIELDAALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Y1</accession>
    <name>A0A231H6Y1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44552">
        <property type="protein sequence ID" value="OXR44552"/>
        <property type="gene ID" value="B7C42_03341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850532" evidence="1">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="17531" checksum="5E220D425BCD123D" modified="2017-10-25" version="1">MSGKLRPVLFISAAVLFVAAVAMASVTGYKYWSDKQIEQARTDSVPAARHAVESVFTYDFKTVDAELPKSADNLTPSFRKDYLKLIQQAIAPGAKEKQLTVQANATAAGVVSAERSHAVVLLYLNQVTTSKDSPQGTVTPSRVRVALDKDDGHWLVDAITPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7J5</accession>
    <name>A0A231H7J5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transport complex subunit RsxB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsxB</name>
        <name evidence="6" type="ORF">B7C42_02805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783400.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44851">
        <property type="protein sequence ID" value="OXR44851"/>
        <property type="gene ID" value="B7C42_02805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="112" mass="11997" checksum="BDB94BE425BBD851" modified="2017-10-25" version="1">MIELVHAPACIACDKCVDVCPTNVFDRGRDGIPVIARQSDCQTCFMCEAYCPTDALYVDPQSTPLPPHQAVPREHIGAYRREIGWGKGRRPGSLTAVGPELPPGPAPKPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7V8</accession>
    <name>A0A231H7V8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44925">
        <property type="protein sequence ID" value="OXR44925"/>
        <property type="gene ID" value="B7C42_02881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="80" mass="8595" checksum="E1F7D8279D124ACD" modified="2017-10-25" version="1">MRRDLSAVADLGSAVDLTDTTGFTVDDMDDDDPVLLTATDGFVVDTWREGYPYPPAKQEPDIVTPADPLIVGRARDVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H887</accession>
    <name>A0A231H887_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45154">
        <property type="protein sequence ID" value="OXR45154"/>
        <property type="gene ID" value="B7C42_03111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895519" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="35083" checksum="FEDD3C0AEA3D06B1" modified="2017-10-25" version="1">MNTGVVMKMVAVALSVGVVATGTSCAVHPDSIPLPGNGVSNAYDLTFEFSSAMNLPGRANVMMDGLRVGEVRAINLSGRAVDVAARIEGDTKVPANVTAVIRQNTLLGDTYIDLERNSDQLDAEFLTAGSIVPLSRTSSPPQVEDVMAVLANFVTGGSIQKIQDAISRINRVMPAPPDVAALSRTVSVDLQDLSRNTDVVDRMLGGLNETAVSVADQGADLSVLFGDSGAIYWRRLSNNVLKYIGILLPSIGSIFEGGFWLVPLLDSMASASGSVRATLEDVPADAETAANFLNRTLVPFLKKPSLDVTSVQTQQGDDLTGGIANLLRILGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8G7</accession>
    <name>A0A231H8G7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45135">
        <property type="protein sequence ID" value="OXR45135"/>
        <property type="gene ID" value="B7C42_03092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="17776" checksum="DCBE12E3403D824D" modified="2017-10-25" version="1">MSASTTRGRLPLRPPVHAARPEAIRTLRLDDIDLGNRRLTIGSVTRPLDELTHRLLTDWLGYRHKRWPNTANPHLIINKQTASNSRAISDNALTAPFRRHAATLEALRIDRQLDEALTHGPDPLHLAVVFGLDETTAIRYCAAARQILQTPAEEHDPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9B7</accession>
    <name>A0A231H9B7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ESX-3 secretion system protein EccB3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">eccB3_1</name>
        <name evidence="12" type="ORF">B7C42_02564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776565.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45439">
        <property type="protein sequence ID" value="OXR45439"/>
        <property type="gene ID" value="B7C42_02564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR45439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="502" mass="53129" checksum="5EB84E3014D6F07B" modified="2017-10-25" version="1">MPSKPTTRWQVSGYRFLVRRMEHALVRRDVRMLHDPMRSQSRAYAAGLVLGVVALAGCGVLALLRPQGSIGDNKILLGKDSGAVYAVIDGVVHPSLNLASARLAVGEPAKAVSIKESELAKKPRGALIGIPGAPSSLNFDSSGKGRAWSICDELKNDGSRDLTTTVLAGDPSLGSKAGKLDSGKALLVQGRDAAYLIYDNQRARVDMNDPKVTEALRIRGMTPRPISAGLLNAVPEVLPITPPKIVDPGGTPAYSLNNHRIGDVVHVDTKDQYYVVLHDGLQPISPLTADIIRNSNPTASENPEISQYDSTQAPPSNALPVQQYPTTAPAIVDAKDQPIECMSWKPLSGAADKADGSKRAELAVLTGHSLPIPDSAQTTPLAQADGSGPNVDAFYSTPGSGFFVQTTGIEADSQRRDSMFFIADTGVRYGIKDAAAQKALGMDADKAKPELAPYQIVGLLAAGPTLGRQEAMVAHDGVAPDPNPAKQLVRSKQDQSAQQPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9D8</accession>
    <name>A0A231H9D8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-fucose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fucI</name>
        <name evidence="6" type="ORF">B7C42_01925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.25" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45633">
        <property type="protein sequence ID" value="OXR45633"/>
        <property type="gene ID" value="B7C42_01925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_N1" evidence="4">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="5">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="5">
        <location>
            <begin position="253"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_C" evidence="3">
        <location>
            <begin position="331"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="470" mass="51727" checksum="F8B1B01B5FD4F68A" modified="2017-10-25" version="1">MARIGVISISDGRDYVHDGIAEFIRTNEDRLVAELTSAGHEVVRGSAPVSTNTLAVSVAREVASAGVDLTVLHYAVWAFPHFTMLVQGATPGALLLLSNIDPVQPGMVGMLAAGGALDQIGRTHTRLWGDPADPDLIAKIGVQACAASAVSSLRGSTFGRFGGRPMGMNTAVANTDQWQRIFGIDVEEIDQWEIVRRAELADAAEVSKARVWLEETTAGVHYDGDKLTPELLERQIRSYLAVRELIDEWNIDFSGIKGQPELTQYFATMDITEAFLNDPYDWNGPKPTHVCATEADMDGALTMQLFKQISKTPVLFADVRHYHADRDIWDLCNSGQHATWFAARSDDPAENLSRVHLYPEVFFFPAGGASVHHLAAPGQMTFGRLTRNDGNYRMQLMLGDFETYDDATNDELMSQSTREWPHAFARLDARAEDFLSRFGANHIHAVPGDHRATVRAACDLLGVTVDEFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9E7</accession>
    <name>A0A231H9E7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lgrD_2</name>
        <name evidence="11" type="ORF">B7C42_02699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45574">
        <property type="protein sequence ID" value="OXR45574"/>
        <property type="gene ID" value="B7C42_02699"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="88"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2238"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3764"/>
            <end position="3839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1187"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2273"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="3799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR45574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="4111" mass="440326" checksum="96CF17D80CDBF6B0" modified="2017-10-25" version="1">[encoded data, 4111 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9I6</accession>
    <name>A0A231H9I6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">linC_3</name>
        <name evidence="1" type="ORF">B7C42_01906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783988.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45614">
        <property type="protein sequence ID" value="OXR45614"/>
        <property type="gene ID" value="B7C42_01906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="26905" checksum="1619E6FD46FEC9B4" modified="2017-10-25" version="1">MTSLFDLTGHVALITGGNSGIGLGMAHGLAQCGADVCIWGTNAERNEAAAEELSKHGTRVRGVRCDVGDEDAVTASFAETLDHFGRIDSCFANAGTHAPDIRFVDTTLADFRSVTRVNLEGAFLTLRTAAKHMVERGGGGVLVGTSSVSSLHGTPRGQAYAASKAGLSAIIRGCAIELARYGINAHSLVVGWTETPLISREMNDPAFEHNVMKRMPHRRWGEPGDFARLAVYLAGGVGGFQTGDEIVIDGGYSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Q2</accession>
    <name>A0A231H9Q2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl-CoA hydratase echA12</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45561">
        <property type="protein sequence ID" value="OXR45561"/>
        <property type="gene ID" value="B7C42_02686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="27245" checksum="050AC27B06D49659" modified="2017-10-25" version="1">MSDHDHTPGLTIVRDDRVLRVTIDNPGRKNALSYDAMIALGDTLGNVTADPSIRVVVLTGAGGDFCTGADLAAAAAEKERGITPEMTMDGANRMIRSIIDAPVPVIARVRGAAAGIGVALALSADFTYASEEAYLLQAFINIGLMPDGGAAALVAAASGRALAAELALLGERLPVTEAYRRGLLAGVLPVDELDAKVEAVAAKLARGPRRALELTKRTLNRAALASLDEALAAEKAGQAELLRGPDFAEGAAAMLGKRTAVFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9U3</accession>
    <name>A0A231H9U3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-methylmercaptopropionyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="10">1.3.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dmdC_3</name>
        <name evidence="10" type="ORF">B7C42_01920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.-" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45628">
        <property type="protein sequence ID" value="OXR45628"/>
        <property type="gene ID" value="B7C42_01920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="287"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="474"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="605" mass="64532" checksum="D1FE373D09A2632F" modified="2017-10-25" version="1">MGHYRSNIRDLEFNLFEVLGLDRVLDSGAFGDLDADTVRAMLAEAARLAEGPVAESFADADRTPPTFDAAAHAVSLPASFVQSTLAWRDAGWHKVGLKPEVGGTPAPAAVKWAIWELLLGAQPAAFVYTSGPQNAAILHDLGNLTQRRWAELAAEREWSGTMALTEADAGSDVGAARTTAIPQADGSWHLEGVKRFITGGDSDISDNILHLVLARPQGAAAGTKGLSLFVVPKFHFDSGTGELGARNGVFVTGLEAKMGLKASATCELTFGGHGIPAVGWLVGDSHTGIAQMFKVIEYARMMVGTKAIATLSSGYLNALAYATTRVQGSDLTRMTDKDAPRVPITHHPDVRRSLLLQKAYTEGLRALYLYAAAHQDPESAAAVSGADAESALHLNHLLLPVVKGVGSERAYQCLTESLQTLGGSGFLQDYPIEQYVRDTKIDSIYEGTTAIQAQDFIFRKILRDEGVAFDHVTGQIAKFLADGPGRLDLERSLLATALADVEDMVETLTGYAAAAQREPAAVYRIGLVSVRFLLAVGDLLVGWLLLRQAEVALAAIDATGSTPFYEGKVAAASFFAKNVLPGLGEVRTIVRDVDPDVMTLDESIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAA4</accession>
    <name>A0A231HAA4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45883">
        <property type="protein sequence ID" value="OXR45883"/>
        <property type="gene ID" value="B7C42_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="454" mass="50103" checksum="4652E6E3E2CEEBC0" modified="2017-10-25" version="1">MSSDSRAGEIRGGAEADTRTGAVTMADERLGVNDAVAAVLTRWIGSMPALYLVLIGFSTWMALATWGPLRPVDPYPFPFLLFVDNVAQLILCLVILVGQRVLSAAADRRSVQTYENTEAIFAQVADLQAHLDHHDRALSRGLSLLESTPHPWIERHRVQPPPQAADQAVSTNDRIAVWLTERLGSVWGFYLALGSQILWVVLAQAGIQRVDPYPFAFMAFLSTLAQLVFMIVIMVGQDVLGRTGDRRSEQTFLDAQAVLHECRRMKARLTAQDRVIDSLTGYVTDRVSEQLGRALHETSERVDHQARAHTVMTTGEAPADAAALRHWNELSDQARRTYRLQARGIGEDLAAIGCFMVPAFDPAFAVTFDDDEIGLLARLDYERRITDRRALLGGSAHPDPDDAEPLPWAELPQSARIRYLQAARRIPVMVSGAGFQVLRSTPARVRGGAHADLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAR3</accession>
    <name>A0A231HAR3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG1</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG1_1</name>
        <name evidence="1" type="ORF">B7C42_02218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778818.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45925">
        <property type="protein sequence ID" value="OXR45925"/>
        <property type="gene ID" value="B7C42_02218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="25008" checksum="C5305C85E39BB581" modified="2017-10-25" version="1">MSNFTSRSVLVTGGNRGIGLAVAQRLAADGHKVAVTHRGSGAPEGLLGVKCDVTDADSIDAAFSEIEAKQGPVEVLVANAGIVDNTLLMRMSEEQFTRVIDANLTGAWRCAKRANRAMLRARFGRIIFLGSVVGQMGGPGQVNYAAAKAGLVGMARAITREIGSRNITANVVAPGFIDTDMTREEMTEDMREMALKVIPAGRIGQTEEVAAAISFLASDDASYITGAILPVDGGMGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAS1</accession>
    <name>A0A231HAS1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45970">
        <property type="protein sequence ID" value="OXR45970"/>
        <property type="gene ID" value="B7C42_02263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021218">
        <property type="entry name" value="DUF2784"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10861">
        <property type="entry name" value="DUF2784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="14253" checksum="6C5EA577B1EE53FA" modified="2017-10-25" version="1">MYRLLADATAGVHFLFIAYLVVGGFVAWRWRWTIWTHIAAVAWGFSTVLVGVDCPLTYLETWARERGGEAGLPSTGFIAHYITGVLYPSSALDLVRVLVVALVMVSWIGFVRLGRRRRYRSPHAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBG1</accession>
    <name>A0A231HBG1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781580.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46283">
        <property type="protein sequence ID" value="OXR46283"/>
        <property type="gene ID" value="B7C42_01249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="12521" checksum="E6282177F9577162" modified="2017-10-25" version="1">MTQAAQQNTEIRDNPQFDRFELWVDGQHAGVAAYQDTASERAFVHTEIYPQYEGLGYGRLLVQGALDRTVEQGFGILPLCPMVHHFVESRPRYLAMVPQWARERFGLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBQ7</accession>
    <name>A0A231HBQ7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">clpB_2</name>
        <name evidence="12" type="synonym">clpB</name>
        <name evidence="14" type="ORF">B7C42_01102</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781453.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46137">
        <property type="protein sequence ID" value="OXR46137"/>
        <property type="gene ID" value="B7C42_01102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="413"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR46137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="855" mass="93248" checksum="800F8735C246E46A" modified="2017-10-25" version="1">MDSFNPTTKTQAALTAALQAASAAGNPEIRPAHLLVALLDQTDGIAAPLLKAVAVDPATVRREAQDIVDRLPRATGATTQPQLGREALAALTAGQRLATELGDEYVSTEHVVVGLAEGDSDVSQLLLKYGATADALREAFTAVRGNTRVTSADPEGTYQALEKYSTDLTAAAREGKLDPVIGRDTEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRGKTLVSLDLGAMVAGAKYRGEFEERLKAVLEEIKSSAGQIITFIDELHTIVGAGATGESAMDAGNMIKPMLARGELRLVGATTLDEYRQHIEKDAALERRFQQVLVGEPSVEDTIGILRGLKERYEVHHGVRITDSALVAAATLSDRYITSRFLPDKAIDLVDESASRLRMEIDSRPVEIDEVERAVRRLEIEEVALAKETDEASKQRLDKLRQELADDREKLNQLMARWQNEKQAIDSVRTIKEQLEALRGESERAERDGDLGKAAELRYGRIPQLEKQLAEAEKNAGKAGSGSLEDEVMLKEEVGPDDIAEVVSSWTGIPVGRMLEGETQKLLRMEEELGHRVVGQAEAVTAVSDAVRRARAGVADPNRPTGSFMFVGPTGVGKTELAKALADFLFDDERAMTRIDMSEYSEKHSVARLVGAPPGYVGYDQGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTILILTSNLGAGGDKDFVMNAVRSAFKPEFLNRLDDVVMFSALDEEQLENIVDIQLAQLQKRLSQRRLKLDVSDSARFWLAVRGYDPVYGARPLRRLIQQAIGDSLAKELLAGEVTDGDLVKVNVAPDGDGLIVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC99</accession>
    <name>A0A231HC99_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase 1</fullName>
            <ecNumber evidence="2">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qorA_2</name>
        <name evidence="2" type="ORF">B7C42_01352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46386">
        <property type="protein sequence ID" value="OXR46386"/>
        <property type="gene ID" value="B7C42_01352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="16"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="31026" checksum="AE060BA0EC361502" modified="2017-10-25" version="1">MSSNHSMRAIQYERVGGPEVLTQVEVPIPDPTGDRVRVAIRAAGVNPADWKMRAGLMPGPPGFPRRAGFEIAGVVDAAGPEARFRPGDEVLGWAQGGGYAEYALGTQLVAKPAELSFAEAAAIPVAANTAGTGLDELAVKSGETLLVNGASGAVGAFVVQLARARGATVVGTASAANQEVVRTLGAIPTTYGAGVAERVRELAPHGIDAVYDCAGHGFLDAAIELRGGTDRIITIADGAAADKGVTFFARTGGPALDIVARVAQSVAAGEFRLPGAARTYPLSEAAAAQRDSETGHGLGKIVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCD6</accession>
    <name>A0A231HCD6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bpa</name>
        <name evidence="6" type="ORF">B7C42_01584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46613">
        <property type="protein sequence ID" value="OXR46613"/>
        <property type="gene ID" value="B7C42_01584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="21264" checksum="C24EE3EB5CBC96F5" modified="2017-10-25" version="1">MDAMTQSDGAPDSIVVIGPEGRPLVIPAGAQGEAPFAGQVVGEGDTDAEGAQTAGGEESLADMVEQPAKVMRIGTMIKQLLEEVRAAPLDEASRNRLKEIHKTSVHELEQGLSPELRDELERLALPFGEDSVPSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMRHALPPGAHMPREGGQGGSVTGGGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCV0</accession>
    <name>A0A231HCV0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46740">
        <property type="protein sequence ID" value="OXR46740"/>
        <property type="gene ID" value="B7C42_01717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12521" checksum="949A888539AB644B" modified="2017-10-25" version="1">MIEHMFEHWPEKGEFALHRVVVPPMPVLVDVAAAIPTYPRMAIPEAVAGPVRAGGLEITGRIPGRLHAWARAADGTWLGLVEFELRTGNGRSRLPVTQWCPAHALIMRGGCGPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCX9</accession>
    <name>A0A231HCX9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylylsulfate reductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aprB</name>
        <name evidence="5" type="ORF">B7C42_01759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030516520.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46781">
        <property type="protein sequence ID" value="OXR46781"/>
        <property type="gene ID" value="B7C42_01759"/>
    </dbReference>
    <dbReference type="GeneID" id="66718394"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8106" checksum="65B0771C5E825DF8" modified="2017-10-25" version="1">MASVNQRADVPVTIDESLCIEGCTLCVEICPLDSLAINPDNGKAFMHVDECWYCGPCAARCPTGAVTVNMPYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDE2</accession>
    <name>A0A231HDE2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46941">
        <property type="protein sequence ID" value="OXR46941"/>
        <property type="gene ID" value="B7C42_00057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393877" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="35564" checksum="BD3821F65B76429D" modified="2017-10-25" version="1">MKLSTRLKAGMGAAALCCSVVVTSTACSLGPNDLPSVTGGIGKSYDLTVRFASVMNLPAGADVMMDGLRVGVVHSVDVSPGRDVSVAVEIKAGTRVPADAHAIIRQDTLLGDTYLALDRDPNMPITTVLQPDGVIPVSRTTSPPQLEDTMAVLAYFVNGGSIQKVEDAMTRINRVMPNLPDVQNMASVVAADFHDLSRNTEQIDRMLNGVNATATAIGANNHTLAEIFSQHGVRFWYLAAKDIVGYIAQILPAIGSIFKGGLWMVPMLDSLANAGGQIRDIYDVTSSDKLTNFLQNTVAPFVKDPSVNIRSVQSAKGDQVIGDVENVLRMLGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI9</accession>
    <name>A0A231HDI9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46964">
        <property type="protein sequence ID" value="OXR46964"/>
        <property type="gene ID" value="B7C42_00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="16856" checksum="539048F93569B5BE" modified="2017-10-25" version="1">MPVMDNVEIVRRFTDGLRVGDVGACLELLDDASVFSETPSLPFGGDYIGPRGFRRMLRAVSRDFSVDLKPPEIAGGDDFVAVAVHGTFTSRATGRSMPVDAVDIYRIRGDKIIRVDVYYKDPHALSELCRRHESAADEGQANSHTSNDRGELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDY2</accession>
    <name>A0A231HDY2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47032">
        <property type="protein sequence ID" value="OXR47032"/>
        <property type="gene ID" value="B7C42_00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12506" checksum="6B8AE31CD9B13DCF" modified="2017-10-25" version="1">MRTGSRVCGAAFDPELFVRATVESVGPCPARADYIEICFSTTEGRWKWCFPEPDPSDCPVEPTTDLAFTLDNYGAQAHPIVDGRIQPAILSAAALPMVLAGTPVHISRRLVVMCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE54</accession>
    <name>A0A231HE54_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47056">
        <property type="protein sequence ID" value="OXR47056"/>
        <property type="gene ID" value="B7C42_00175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="234"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="608" mass="66463" checksum="A4C1AC1F9AB1E5EA" modified="2017-10-25" version="1">MHDPDPPFRPIHRNDGYLPLEDYGLIGDGTTAALVGVDGSIPWLCLPRFDAQPLFCGLLDRARGGHFTVAPIDPLEGRQRYQPDTGVLETGLRSATGVLRVTDAMVVRPGSDLGDDAPADRSELVRSAIVVSGHVRVSVEIAPQGGAQLRPVLSGLEIRVASQPNLRLHLRADRPLDGVHTTVDLAQGERLELVLSWGRFHRHHRFDAEAMLRHTADAWRSWMRTCTYDGPEQALVRRSAITLKLCDHWVSGSVVAAPTSSLPAPIGGVRNWDYRYVWIRDASYAVYALRRIGFRNEADAFLGWVLDAFERSGEPRIMYDIDGDPVPDELVDTGLEGYRASGPVRWGNGATDQRQHDVYGEILDCADQWLRTGGELQPVLWSNLSDLAEAAGRSWQEPDQGIWEVRSAGRVFTYSAALCQVALHRAASIGERFDLPGPVGTWRSTANEIREAILKNSWDERAQTLSAHLDGGGELDASLLALPLRRVVPADHPRMTATTAAVADRLGAGDGLLYRYLHEESPDGLPGNEGAFLLCSFWLVDNLTAQGRLEDAERLYTSLCARASTVGLLAEQIDPTTGAFMGNFPQAFSHIGIISSGVKLARAKAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEA5</accession>
    <name>A0A231HEA5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777827.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47280">
        <property type="protein sequence ID" value="OXR47280"/>
        <property type="gene ID" value="B7C42_00402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="28377" checksum="87D2A725419B5B71" modified="2017-10-25" version="1">MAEWSWDPDDFAVLWYSDANDRIPVPLRYTSKLATNDEVTAHRAAVRARYGTDEFEQIHLALHTLTTSELRIEIHGESAVLGKGRPREYRVIGARTPYHAVMLTQTADGDVDGPIRCRLFPTDQLAGRLAAIVPGFPPGSGKPDTFHIDDLRAPDDGYTRNATRDRFHRLTARPLDGTGMAGLLAGYLHSRPDPWNILGWFDVTGDGRYLREQSREHIAIRPAASRDLAAHFETWIDRAVRRLREEQPATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEL1</accession>
    <name>A0A231HEL1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menI_1</name>
        <name evidence="3" type="ORF">B7C42_00442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.28" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777807.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47319">
        <property type="protein sequence ID" value="OXR47319"/>
        <property type="gene ID" value="B7C42_00442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="PTHR21660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="16900" checksum="1C86A698FE63EF9E" modified="2017-10-25" version="1">MDEAAHEQASPAVRARIRDSFERQGLMRHLGARLAHIGPGRVHIELPHRPEVTQQHGYVHAGATSAIADSAGGYAAYTLFPDDSSVLTVEYKINLLAPAEGDHLEAVGVVLKSGRTLTVCRLEVFGVRDDRRTLIATGQQTLICLSGTSDQPIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF46</accession>
    <name>A0A231HF46_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503530.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47601">
        <property type="protein sequence ID" value="OXR47601"/>
        <property type="gene ID" value="B7C42_00726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="31967" checksum="68FE8DBEFD35A9DB" modified="2017-10-25" version="1">MAGKRTVLTVQLRRLAALLSEMREQAGISKEVVSARTGINVTTLYRIETAQARPQRRTLTAMLDLYGIGEPQRSDAVQLLMEAQKPGMSRPFEAAVSEVYAAYINFETEALSARLFQTSFIPGLLQTERYAWAVLDTAMPKVETSVIEQRLRARVERSKVLTRDGNPLELWVVLDEAAIRRVVGGPEVMREQLLRLTEDTDKRNVILQVLPFGAGAHPAMVGSFVVLDFPDPADPELVYVEGIAGDDIVEGHNEIRRFGVMFDQLRAMALSPRDSAEMINEIADGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF59</accession>
    <name>A0A231HF59_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum-pterin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mopII_2</name>
        <name evidence="4" type="ORF">B7C42_00479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779954.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47356">
        <property type="protein sequence ID" value="OXR47356"/>
        <property type="gene ID" value="B7C42_00479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7231" checksum="DEBA3A0090A0A1C7" modified="2017-10-25" version="1">MRLSTRNQLDGTVVSVTRGEAMAVVRVRLTGGDEITSSITRDAVDDLGLAAGSTVKVLIKSTEVTLGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFB6</accession>
    <name>A0A231HFB6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ispH1_1</name>
        <name evidence="5" type="synonym">ispH</name>
        <name evidence="6" type="ORF">B7C42_00699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47574">
        <property type="protein sequence ID" value="OXR47574"/>
        <property type="gene ID" value="B7C42_00699"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="391"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="475" mass="50152" checksum="CC1DADDD713A5297" modified="2017-10-25" version="1">MLRGAATAPVVHTGRGPRRRYDAAASGPVAVAGVAGALTTELRPGDLVVAGEIRRNGTELPSPAAVLLHGELLRLGLPARLGPVYSAEHVVTGRARAALAESGALAVDTETAFLAADAPDGQAVALRAIVDTPDAPLLSPGTLWRGVRALRSLRAAAPALDRWSAATGEREILLAGPRSFCAGVERAIEIVEQALDRFGAPVYVRRQIVHNSHVVHELARRGAVFVEELDHVPEGAVVVLAAHGVAPEVRRQAERRRLRVVDGTCPLVSKVHAEVRAFAAADKTVFLIGHAEHEEVVGTRGEAPENVVVVADPEEATRVSPPDPDRVAYVTQTTLAVAEAEATAAVLRQRFPALSGPRKDDICYATTNRQQAVRAVARESDLVLVLGSRNSSNSLRLAEVAAAEGVAAYLVEDAGEIELNWLAGTRRIGVTAGASAPPHLVDDLVEALSGLGALRVRHTTVTEESIRFNLPREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFH4</accession>
    <name>A0A231HFH4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glutamine ABC transporter permease protein GlnM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnM</name>
        <name evidence="8" type="ORF">B7C42_00825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47700">
        <property type="protein sequence ID" value="OXR47700"/>
        <property type="gene ID" value="B7C42_00825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="16"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="24447" checksum="AE00BD824C54115A" modified="2017-10-25" version="1">MFDLISRYDNQLWDAFWVTIKLTVFSAIGALIIGTLVAAMRVSPIPVARWIGTAYVTIFRNTPLTLILVFCSLGLYTTLGIKLASESSGLDFLPTNNFRFAVLGLSVYTASFVCESLRAGINTVPLGQSEAGRSLGLTFGQNLRHVVLPQAFRSVIAPLGSVLIALTKNSTIASAIGVAEAAALMASMNETEADILAIGAIFALGFVILTLPTGLLFGWLAKRFEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFQ2</accession>
    <name>A0A231HFQ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fldA_1</name>
        <name evidence="2" type="ORF">B7C42_00794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513190.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47669">
        <property type="protein sequence ID" value="OXR47669"/>
        <property type="gene ID" value="B7C42_00794"/>
    </dbReference>
    <dbReference type="GeneID" id="66720519"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="15881" checksum="8E69A47DD69BBD41" modified="2017-10-25" version="1">MPTLLIIHHTPSPFLQDMFEAVVAGATDPEIEGVEVVRRAALAVTASDVLAADGYVLGTPANLGYMSGALKHAFDTFYYPCLDSTRGRPFGVYIHGNQGTEGAERSITTVTTGMGWQQAAAPVIVTGQPGKDDREKCWELGATIAAQLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG27</accession>
    <name>A0A231HG27_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminoacrylate hydrolase RutD</fullName>
            <ecNumber evidence="3">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rutD_1</name>
        <name evidence="3" type="ORF">B7C42_00903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043618.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47778">
        <property type="protein sequence ID" value="OXR47778"/>
        <property type="gene ID" value="B7C42_00903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="308" mass="33505" checksum="11DD2634C9107CD4" modified="2017-10-25" version="1">MIGSTQGTRVAPHSQGTASTAPTRDGRRLYYMHRPGRDDNRSALVVFESGLACTRSYWAAVQREFDDYAATVVYDRSGLGRSAPDNAPRGLRRLADDLVDLLDHLTERFAAPRFVLVGHSWGGPIVRVATADRHDRIAGTVLVDPTDEFCDDLFTAASRRAARTGQRLSAALARIGALRLAYRDTLTALPADARADFRAEGFTAAAMRTRAAELACHTVDLEQLRDAGPDRRDIAVTIVSADSASAGISARSRAAINAAHRRRAARPHGRHVIAEHCGHMVPTQRPGLIAAEIVRIIDEYGPERRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTH1</accession>
    <name>A0A231GTH1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782338.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39920">
        <property type="protein sequence ID" value="OXR39920"/>
        <property type="gene ID" value="B7C42_08025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="118" mass="12759" checksum="DE36FDC82BE83292" modified="2017-10-25" version="1">MTATITTPAALIAAALGIDADDRVRIEVTRDGWDNAMCEETGAPGAVEVEWVTVDGDRTDRTFAGDIAGDHINALLLSDQVDQYETITVKVCRAYLRFVHPQLADTADRVDMPARIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU16</accession>
    <name>A0A231GU16_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39981">
        <property type="protein sequence ID" value="OXR39981"/>
        <property type="gene ID" value="B7C42_07932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="13724" checksum="2629467FFEDD0C2A" modified="2017-10-25" version="1">MNDLGPHITPMWFVWDGGCLWISSQIRTQRWIDITRRARVAVMVDAGTELTDLRGAEFIGDAEVVGEVPRAGTSDPDLVVPEKLFAEKYFGSGTMDHDGKHAWLRIRPSAVRSWDLRKTATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUE1</accession>
    <name>A0A231GUE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_40</name>
        <name evidence="1" type="ORF">B7C42_07846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40091">
        <property type="protein sequence ID" value="OXR40091"/>
        <property type="gene ID" value="B7C42_07846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="24935" checksum="E89E1AE188291209" modified="2017-10-25" version="1">MAEHTRVALVTGASGGIGRAVARRLAADGMAVGVHYAGNETAADELVAELEERGGRALAVGGDVADEHAMGAAFDAVEAALGGIDVVVNTAGIMTLGPIADFDLEALDRMHRINIRGTFVVAQQAARRVRSGGAVITFSTSVTRLAPPGYAAYAASKGAVEAMTLILARELRGRDITVNAVAPGPTATPLFLDGKDQAAVDRLAAQSPLERLGTPDDIAEAVAFLAGPGRWINGQVIFANGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUJ0</accession>
    <name>A0A231GUJ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40287">
        <property type="protein sequence ID" value="OXR40287"/>
        <property type="gene ID" value="B7C42_07625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="563" mass="61023" checksum="C01040BB756A5539" modified="2017-10-25" version="1">MSPTTLTVVPDIEPADASPAPLGDATGAESATSAESAENERDPHRAGGAALEVPPNATAAYMDPRELVIAENVRTGFDVAEHPKQADSIREFGVGAPVLAEREPDGSVHVLDGQVRVLIAQAVGLTRVPVWITDAPVDVDVKQRRIDRTMAQINLNERRIPLTQADYAAGVALMLDLGASPTRVARGLQQTKRAEVRKLAAVGRSATGRELADAGQYSLDQLAVIAEYDNLGDTDAVEKLTTTSRYNFSYTAKAIAADRDETRRRLHASLPYAAYGFGILTDEPGPDDAYLPATELTRADGEPVTDDDVYADPARWVVWVDVEENAELVDTATGALVDPDTVDWDTQHDPGTEPGEGLRRADGLAWRDRWIPAYYLPADQLDTTGLQRPVHQAADPQEALAAAERAAAAREEARLARRRVRELNKRGVAAAERREEFLSKYLARSKPPVQAAHFVAEYLARNLAPGALQLVTKLLGVGWSTEELVKVIGAASTNRAWVLALGMVLANREVGLDKSLWRTRSEPTARYLHLLADIASPDDDFALVDVEQAAAGDIDFHDIPIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUL6</accession>
    <name>A0A231GUL6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40245">
        <property type="protein sequence ID" value="OXR40245"/>
        <property type="gene ID" value="B7C42_07670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="12776" checksum="AD8EB90526B3FF7E" modified="2017-10-25" version="1">MTSIWPQRYRCHNPYCGERSHYSMVCPNPYRSRVPTTEGDYRSYLRWKRMWLEGDFDLNRTPSYMRERAEKRAETARQRPGPGYGWLLVVMPAALLLAVVMGALILYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUV6</accession>
    <name>A0A231GUV6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778573.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40410">
        <property type="protein sequence ID" value="OXR40410"/>
        <property type="gene ID" value="B7C42_07468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="28462" checksum="127C28BC2134499A" modified="2017-10-25" version="1">MDTEKYGPWAVIAGGSEGVGAEFAAQLAEQGLNLVLLARKEAPLEATAEKCRAYGVTVRTLSVDLLSADAFERIRQVTDDLVVGLFIYNAGANTYGHEFVTGDLDRFQAVIDLNITAQLKLVQHFGALMRERRRGGILLAGSLSGFLGSAQISIYSAVKAFCRIFAEGLWLEMQDYNVDVLELVLGLTRTPAMARAGLRMDAPGLLISEPRDVAAQGLANLANGPVMVVKEWEAAAEKNSGPNRAELLMESRESAKKLLPPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUZ6</accession>
    <name>A0A231GUZ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative multidrug resistance protein EmrY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">emrY_3</name>
        <name evidence="7" type="ORF">B7C42_07511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778543.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40453">
        <property type="protein sequence ID" value="OXR40453"/>
        <property type="gene ID" value="B7C42_07511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="537" mass="56522" checksum="EB4069BCB9D2C283" modified="2017-10-25" version="1">MTTTSTEAGSEVPDETGRLDGASRLRIFSVLAIIVLFTEVAPIQYTMIAAALQKIAPSFPGVGANITWAMIVFGLIGAAASPLIGKMSDVWGKKRMFVICGLLFIVGCLLSAIATNWTVFLVGRCLQSSAIATAVVAYGLIRDLMPRKYVTVGLGITSTGFGFSAALAPILAGWLVDNYSWRAMFWFLFGFAVVMLPLVLLFVPESKLRVRESIDFVGAGLISIGGALVLIYIDKGQDWGWAKPTTLAWLIVGLLSLALFVAVEFRVATPIMDMRLLFHPRVSLVLLAAVLASCMIGVQGYAVAYMVQTPDQSVIKSGVVDATLAQVTKLTGHELPPEMVSVGFDPGYSYGSGFTLLEFALKISLSFGVLAMVFGLVGGVLARKFGARLPLLVAATIFTTGAVVQAVAPHTWQLFAVVSAVLGIAQGCYYAAAPNLITEAVPQEQQGISVGMLGIMQSMGVAVGVAVVTAFVNAHPVRAVVSVAGQPPQTSVIPGVYADRGYELGFWFAAIAVGAALVIALVMRHGRTPATGGAAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV74</accession>
    <name>A0A231GV74_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778737.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40530">
        <property type="protein sequence ID" value="OXR40530"/>
        <property type="gene ID" value="B7C42_07339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12531" checksum="B40BE1E8D4EDC09A" modified="2017-10-25" version="1">MNMKPLSESLMDLAVRVKQFEDSSAGARDKSRAALQAQREKLTTTLEHEGHEFEKTAGELRDAAQSWWSDTQEAIERQISVMRADFEKWQASIRAQRGGRPAELTEPANKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVA5</accession>
    <name>A0A231GVA5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40544">
        <property type="protein sequence ID" value="OXR40544"/>
        <property type="gene ID" value="B7C42_07353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="22266" checksum="A62129AE06C9D090" modified="2017-10-25" version="1">MPAFQTPEPIAVAVEVLSGTVTVTASDRTDTVVAVRPADAAKKGDVRAAEQTRVEFVDGTLTVTTPKDWRTYSPFGGNPTIEVAIEVPAGSRFQGTAGVGRILGAGELGECVLEVSAGDIVVERPLGSVTAKTAQGNIRIAEATRGVLRLETSTGELEVGIRPGSAARLETSVARGAVHNQLVPVDGAQDDEHTVRVYARNAFGNVIIRHASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVH0</accession>
    <name>A0A231GVH0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780094.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40471">
        <property type="protein sequence ID" value="OXR40471"/>
        <property type="gene ID" value="B7C42_07409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="30872" checksum="A70A9C3B13B6211F" modified="2017-10-25" version="1">MARSEFGEFLIARRAQLQPEDVGLPVGRRRRTPGLRREEVAALAGVSVDYLARLEQGRDTNPSMAVLGALAEALRLNEVERHHFGNLAVGMEHARECPSSGQAREQVTDTVQAVLDAMHPTPAFVVGRWLDILAWNPAWRDFAEPLGLLDEAAEHNLATYFFAHPQAPQRWRDWPVAAEMMVSTLRSARTHWPDDPGLDALIQGLHRFPEFSCRWREHRVTEFRSGALHIDHPQRGEVEVEIQTLSPAIDQSVQVWLVDRRAARTPALRLVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVH1</accession>
    <name>A0A231GVH1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909789.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40614">
        <property type="protein sequence ID" value="OXR40614"/>
        <property type="gene ID" value="B7C42_07299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="33733" checksum="D2DB8EF977D7CA68" modified="2017-10-25" version="1">MKPSSVISLAAIASVLVFGIGYLAIGVLRIEWFSTRTHVTMALPEAGSLKSGSPVLLRGVKVGRIVAIEKAVRGVEVKLDLDSAYRIPASGTATVEDLSALGEPYIEFAPKSSDGPYLRDGQRLESAQVVLPRSIPDVAQTVTDLLKQLNPQAISDIVRTLDQALTGTQAVMPKLAASTTLLSETILSRSPAIRQILVNLQTMGSDMDWAGPSMTAAGPLWEEAGTWGALIADSIARLARIGNMPEDYMQGNGVVPFLGKVGDYLDRIGPELRQLAPTIQPLAESAKSSMPQIDLSDLIARALSATGEDAIQVHIGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVQ6</accession>
    <name>A0A231GVQ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40652">
        <property type="protein sequence ID" value="OXR40652"/>
        <property type="gene ID" value="B7C42_07209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="27843" checksum="5C32472E02028C33" modified="2017-10-25" version="1">MVRQVNALQAEKVPQIDDALIKCSNLFDLLKDDSGNVVFDGGRNIDELSVLFMTVPGLDKDAARSQVAATLRMVMQRAGRKRKDQRRSVTLYLDEASALTTKQGSLGLEEIAERGRSQGVAMVFAGQSPESLAADKWSLDRLLKACAGGVLIGYGENFGELCKHFGSRRVMLPSRHLIKGQRHGDEGQVSVGEKWLVDPDRVRQFETGDFVFAKKGRAFYGRIVPLDTKRLTPLPGTAAAKKTATQPGIGGAATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVT4</accession>
    <name>A0A231GVT4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative type I restriction enzymeP M protein</fullName>
            <ecNumber evidence="5">2.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234858">
        <property type="entry name" value="M.Nce30759ORF7163P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40739">
        <property type="protein sequence ID" value="OXR40739"/>
        <property type="gene ID" value="B7C42_07163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="147"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="681" mass="72784" checksum="C9B5011F944BE257" modified="2017-10-25" version="1">MYTEGRGMPKSASPVTASEISRLAGVTRATVSNWRRRHTDFPSPIGGTESRPVFDLHQVQEWLSAHGVEAPQSPLIELRTYLRSQAEPSDIAQLMESLQWTGERWESRPSASPGGPVLKVLQRAADIEGSRAALDVLAERGLEDVAATGVYQTPGPLAALMAELAEPPVPQQLHSALDPACGSGSLLLAAARGGATQLYGQDTLPVQVQRTRLNLESATLEPTVRVGDTMSDDAFPGLEVDAVLCNPPYSDREWGADELALDPRWQYGVPPRGESELAWVQHALAHLKPGGRAVLLLPPAVASRPSGRRIRAALLRSGALRAVIGFAPGIAQPWHVGLQLWVLRRPENVEPAPDTMLFIDASAASGGSGDGTDWEALRRAVLDSWRAFDGGSSDAATMPGVATAVRVMEVLDESVDVTPARYVRSSFDPALLSTEVEAAIRDLAGHVATLAAMIDDFGAWRQSDGKPWRTATVADLAGGGALQWFRASPPRPKNEDPADDHRRVLTAMDVVSGHSPSGTFATSEPAEAVIVTVGDVLIPAVRSDASGARSARVAGPEDAEAVLGPHVYLLRPNAQRLDSWFVAGFINSAENASTTRTSTIRFDPSRLRIPLLPLHEQRRYGAAFQRLYEIRSSARRLGDASEHAIGLVASGLTAGALEPASNTTRPDNVETTKQKIPGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVX8</accession>
    <name>A0A231GVX8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40779">
        <property type="protein sequence ID" value="OXR40779"/>
        <property type="gene ID" value="B7C42_07203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="40797" checksum="61162ABBF7D51FD9" modified="2017-10-25" version="1">MDSDGRQDRRGLKLLTERAGEPFGFVASAFEPIRLTQARRWAELSVGELAAAAGLSAAVVEQYEIGAVQPDSDVPADLARALNVPVDYFATGRPMCRIDAADLHFDDPGSATASDRAKAVAFAEYLWELAYALACRMRFPELDLPALDEGTEPADAARLLRDHWGIAPGPLAHLGATLESRGIVMAFAPATSAAMARVGTYAAHTWGRALIVVAARHTQCVYGYRFACARALGHLLLHPCPLPGDRTQAEEADRFATELLVPADDMDQLFPSPIHFPSPAALARQWGVPIEVIRRIGRERGPRMHILEPTRTWDHDREPVAGYPGEAPGLLAEAVARARSAGFGRAELTDELRWTSWLLAEVLGEAQVGPHLSVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW83</accession>
    <name>A0A231GW83_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bicarbonate transport ATP-binding protein CmpD</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cmpD_3</name>
        <name evidence="6" type="ORF">B7C42_07025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782139.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40890">
        <property type="protein sequence ID" value="OXR40890"/>
        <property type="gene ID" value="B7C42_07025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="31484" checksum="781DCD92BE6F73F8" modified="2017-10-25" version="1">MSQQVLVEQVEKDPPRPAPTAWKIEAKSVGKLYPRTDRRAKEATTVLDGFDLRIGSGEFVSLLGPSGCGKSTFLNILAGLETYNGGAVFVDGKRVEGVNKNVGVVFQGYALFPWLSAQKNVEVGLKVRGVAKAERRERAAQVLRTVGLESAAHRLPHQLSGGMRQRVAIARVLAYEPEVLVFDEPFAALDAQTREFLQSELLRIWESGATKKTVLFVTHSIDEAIFLSDRIAVMTRAPGRVKAVLDVELPRPRDAAVRSSEDFVHIRSRVARILEEEVRIGNDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF3</accession>
    <name>A0A231GWF3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40960">
        <property type="protein sequence ID" value="OXR40960"/>
        <property type="gene ID" value="B7C42_06926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="28195" checksum="20F7E6CFE71BE191" modified="2017-10-25" version="1">MPIPHNDEGADPAAVAGFRANPVAGRGRHRLREPDGESPARHPAAGDDGHAYTGEDREEEIQQTLLEQLGGISGLIYSTLPVVVFVPANTLWGLTAAIWTALATAAGVLVWRLIRRSPIQPAISGFIGVAVCAFIAHRTGAAKGYFLFGIWASLVYAGVFLVSLVVRWPLAGVIWGVLNGHGHSWRSDRRAMRLYDLATVVWVVVFGARYLVQNHFYDTDSTGWLAAARIAMGWPLTAVALLVTVWAVRRAGHMPVSSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWJ0</accession>
    <name>A0A231GWJ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40935">
        <property type="protein sequence ID" value="OXR40935"/>
        <property type="gene ID" value="B7C42_06901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036275">
        <property type="entry name" value="YdgH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159871">
        <property type="entry name" value="SSF159871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="9440" checksum="F2A5C21323BEB9CD" modified="2017-10-25" version="1">MVRARAEELDAAPTEGFERVGAVEMTLSRFGAGDIHGSIDEIAYAAADLGGEYFYVTDSLGAQVTAVVYRRRRRRRKWFRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWP1</accession>
    <name>A0A231GWP1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41050">
        <property type="protein sequence ID" value="OXR41050"/>
        <property type="gene ID" value="B7C42_06820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="308" mass="31335" checksum="7AD7DA5FE675A34C" modified="2017-10-25" version="1">MRAVVVRRVGGPDALEVVRAPVPEPGPRQVRIRVEAAAVNPVDIATRSGALIAAGLMAPRDTIGIGWDVAGTVDSIGPGVTTFVVGQRVIGLRDLLDRSLGAYAEYLVLDTDAVAPAPPDVDATEAATLPLNALTARQALALLDLRAGETLLVTGAAGAVGGFAVELGVRSGLRVVAQVAEEDAAFVRGLGAEWTVPRSCADLAEAIRALVPGGVDGALDGAGLGVRATAAVRNGGAYAGVAGGRAPVPLRGMRIHQEWIRADGTALAELAALGLTLRVADVLPLERAAEAHERLSAGGLRGRLVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWP2</accession>
    <name>A0A231GWP2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metallo-hydrolase</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41002">
        <property type="protein sequence ID" value="OXR41002"/>
        <property type="gene ID" value="B7C42_06968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="6"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="27824" checksum="2F6B5FC871159D0C" modified="2017-10-25" version="1">MAMGMVDHCLLIETRTGLVLVDTGFGLDCVRDPGRFVGPGRFLLGIRPAEHHTAIRQIQALGYDPADVRDIILTHLDLDHAAGLADFPEATIHVHGPEFRAATAGRTLSERLRYRAAQWSHGPRWMVNELDGTDEWFGFRAVRDLPGLPPEILVVPLPGHTRGHVGVAVDTGSGWLLHAGDAFYVASEIDPAGPKTPLFWWSFELGSIVRGAYLENRRRLVELGRAHGNAITIVNSHDAELFARVTGNSVRPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWZ4</accession>
    <name>A0A231GWZ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">General stress protein 18</fullName>
            <ecNumber evidence="1">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfkM</name>
        <name evidence="1" type="ORF">B7C42_06868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41098">
        <property type="protein sequence ID" value="OXR41098"/>
        <property type="gene ID" value="B7C42_06868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="14112" checksum="A78CC075B4523297" modified="2017-10-25" version="1">MANALQGKHIARPAADGIERVELDRLRDAVSDAAVDVYDALPLRGGTANPDKLRIAEAAVSFVREFVGSRKSIGAGETLTPCPSLRADLRNAGADVVEEIVIYDSLIPRRSPDDLSAVCQAVVEQLAKTGTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX75</accession>
    <name>A0A231GX75_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crt_14</name>
        <name evidence="1" type="ORF">B7C42_06622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41224">
        <property type="protein sequence ID" value="OXR41224"/>
        <property type="gene ID" value="B7C42_06622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="26982" checksum="2DB11CFB92CC3753" modified="2017-10-25" version="1">MTTPDLVDRFIDGVYRLTLNRPRRLNALSDDMLDALHDRITAVPADAIAIVIHGEGRAFCSGHDLKDAADAGPLDTVSARAVAERMQRVATAMRDCRVPIITQVHGYAIGGGAEIALSGDIVIAAQDTRFQFTEASVGRVVTNGFTNLLPRTVGPVRAKQLFLLGRPMSAEEALHWGLLTEVHPLDALDEAVEQIIGELREKSSWALGAAKSLVNRGLQASFESSLEFEIGAAIEAELGPDAAKGASEFADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXC9</accession>
    <name>A0A231GXC9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41232">
        <property type="protein sequence ID" value="OXR41232"/>
        <property type="gene ID" value="B7C42_06630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8459" checksum="1A3D5333CC81F7E5" modified="2017-10-25" version="1">MGAGGSAEPAAEGDVHLRIWLGGTAFGYRATVAAAYQLIRDWQRRRWCAIEFIAHTVEEHLPKRRLPNERLFLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXD2</accession>
    <name>A0A231GXD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate 5-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gno_2</name>
        <name evidence="1" type="ORF">B7C42_06623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.69" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41225">
        <property type="protein sequence ID" value="OXR41225"/>
        <property type="gene ID" value="B7C42_06623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008874">
        <property type="term" value="F:gluconate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28037" checksum="85B786A3AB09580B" modified="2017-10-25" version="1">MPVSEALTASEVGRGIFDLTNRRILITGASKGLGRALAVGLAGFGATVACVARSEEGLAETAALIKEAGGAPAVVRAVDLRDPRNVEETVEAVAAELGGLDVLVNNAADDHDSAIEDTDLETWQRVNDLNARSVWLLSKVAGRHLQAAGGHGKIINIASVLGTVGVRDNTAYVMSKHAVVGLTKALAIEWARKGVQVNALCPGFVVTEMTAHMHADEAGNRWVVRQTPMGRWGQTSDFVGSAVFLSSRASDFMTGQALYVDGGYTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXF3</accession>
    <name>A0A231GXF3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fadK_6</name>
        <name evidence="4" type="ORF">B7C42_06695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41297">
        <property type="protein sequence ID" value="OXR41297"/>
        <property type="gene ID" value="B7C42_06695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="463"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="563" mass="61034" checksum="F7036054A660ECE2" modified="2017-10-25" version="1">MTSERNLGRYTQAQIEEFYATGQWADINFTELLRSRAEANPDKVFVTDGTYALTFAELYDTSQRLALGLHRQGVRTGDRVAVQLPNWAAFVLVAAALARIGAVMVPIMPIYRKDEVSHVVSDASIRMAIAPAQFKGFDYLSMFEEIRKDSDTLESIVAVRAPEDARDGLAERGIMVLEDLIAADESASVDAALDLRVHPDDPFVIVYTSGTTSRPKGCLHTFNTYASGARALVVAFGHTEADVQFGPSPITHTTGLVTSVLIPLVAGASSHLMAEWNPERGLAEIEKFGCTAAVTATTFLQTLVAAAEEHPEFDLSSLRVWVCAGSPIPAAVVENAKAKLPSTNVLSLYGRSENLSTTTCRINGDPRRAITSDGTALPGSEVRIVGPDGNELPRGAEGDIAYRGPEHMIEYLNRPEETAELFTPDGFSRSGDLGVMDEQGYVRVTGRTKDIVIRGGMNISVREVEDKLADHPDLLALAVVGMPDERLGEKVCCYVVTKEGHTPPTVEQLRTYLTDRGVAIQKTPERVIAVDELPMTATGKIQKHLLRMRVAAELSQPTAAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXW7</accession>
    <name>A0A231GXW7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-CoA--L-malate CoA-transferase beta subunit</fullName>
            <ecNumber evidence="1">2.8.3.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smtB_7</name>
        <name evidence="1" type="ORF">B7C42_06558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.22" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41415">
        <property type="protein sequence ID" value="OXR41415"/>
        <property type="gene ID" value="B7C42_06558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="43858" checksum="ED6FF448D7635D3A" modified="2017-10-25" version="1">MEIRPLAGVRVLELGNYIAAPTAGRILGDFGAEVIKVERPKTGDELRNWRLYGGDTSMLYRTVNRNKKSITLDLRTDAGRAIVLDLIRHCDVLLENFRPGMLEKWGLGPGVLDEANPDLVITRISAYGQTGPLSQRPGFAAVAEAIGGLRELVGDPDRPPVRVGVSIGDSIAGIYAAFGTVLALFQRKGAEERIPLPQRIIDVALNESILSVMESLVPDYEAYGINRQRVGGRMEGIAPSNAYPCADGTSIIIGGNGDAIFRRYMQVIERPDLAEDPELQDNAGRWRHRDRLDAAIGEWSVRHTRDEALAILERAGIPCGPIYTAADIVADEQYRARNMIQHFPVDVGAAEPKQVAFTGIVPVIGERSLPIRTVGPDLGEHTREVLSELLGMSDADIDGLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXX4</accession>
    <name>A0A231GXX4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41450">
        <property type="protein sequence ID" value="OXR41450"/>
        <property type="gene ID" value="B7C42_06593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18646" checksum="C781D93CAB19C491" modified="2017-10-25" version="1">MSAESLRASATELLENWKPATHPEQSVREAMLAFLGSAPRGCLREHAPGHITASAVVFSHDEREVLLTLHPRVGRWIQLGGHCEPGDETVVDAALREATEESGIAGLQVEPGLYGAQAHPITCSLGVPTRHLDLLFKIRAPRGAVPVRSAESTDLRWWPVDALPADSDVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY36</accession>
    <name>A0A231GY36_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Steroid Delta-isomerase</fullName>
            <ecNumber evidence="2">5.3.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ksi_2</name>
        <name evidence="2" type="ORF">B7C42_06426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41534">
        <property type="protein sequence ID" value="OXR41534"/>
        <property type="gene ID" value="B7C42_06426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12271" checksum="DB7A5FF5DDCC0E97" modified="2017-10-25" version="1">MHRYLEAVGSGSAADVAACYSEDATVEDPFGSPPHAGRAAIEKFYGALDSAHMRTELLDLRIAGGAAAFRFRVVTETGSRTTTIEPIDVMTFDEDARITGMRAFWSPEDVRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYA5</accession>
    <name>A0A231GYA5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41597">
        <property type="protein sequence ID" value="OXR41597"/>
        <property type="gene ID" value="B7C42_06238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7144" checksum="F03B3EE15BC18C2B" modified="2017-10-25" version="1">MPTPDFAAAATEAERALDVLGADGVVLLANARGIYLGADGQDELFRVLDERAAVAFVRPAAPCDDAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYG3</accession>
    <name>A0A231GYG3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase DesK</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">desK_4</name>
        <name evidence="3" type="ORF">B7C42_06279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41638">
        <property type="protein sequence ID" value="OXR41638"/>
        <property type="gene ID" value="B7C42_06279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="289"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="43671" checksum="FBB2C2D75090FB1E" modified="2017-10-25" version="1">MRRFSLWLRGKPMVADSILAAALVLFDLLTLGGKDHTIVYLILGLLVPVPVIWRRSYPRASAVALLVLSITTSAVSVVLHEDLQPPALLAVGVALYTLVAYVGRREGLLYLAGLAVDGAFSLAVVDQSVPIVIGFLIMFYALCWTLAEFLGARHAYDAEVAARLAVADYDRERSAHDAVSTERTRIARELHDVVAHAVSVIIVQADGAKYALRRDPEIAEQALATIAATGREALRELRRTVELLRTEHAPEQLPQHGTAGLAKVVEMMRNAGLAVELELTGELDDVAPEVSLGMHRIVQESLTNTFRHAGPDPQAWVRVRRRDADVLVEVLDRGDAPSATGSTVAAKAPAVDDTAVRNGIAGSGLGLVGMRERIAVLGGTLEVGRRPEGGWRVCATIPLQRELPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ3</accession>
    <name>A0A231GYJ3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">lnt</name>
        <name evidence="10" type="ORF">B7C42_06283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41642">
        <property type="protein sequence ID" value="OXR41642"/>
        <property type="gene ID" value="B7C42_06283"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="220"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="530" mass="56774" checksum="5A1656FE9955690B" modified="2017-10-25" version="1">MLGVTWRVWGRIGAAVVAGLLVFASFPPRTCWYLAPIGIAILTLVVRDATRLRGGFGYGLLAGLAFFLPLLPWTGIYVGPVPWLALSAACALYVGLFGLLSRLVCDLPGWPVWVALMWTLTEWGRSSFPFGGFPWGRLAFGQADGWYLPLAWLGGAPVVSFAVALTGTVLAALLLRLRPRVTARRAVVIITLATVVAIIPITGVILRTALPAPDDGDRSITVAAIQGSVPRLGLDFNAQRRAVLDNHIRRTEELARAVAAGTAAAPDVVIWPENSSDIDPLRNSDAYDEITAASRDIRAPILVGAVLVNDDRTTTNSVIVWDADGPGERHDKKIIQPFGEYLPYRGFFRHFSDYADRAGYFVPGHGDGVVHARPASGGPMVAIGVATCYEVAFDRAFEDSLRAGAQLLTVPTNNATFGDSDMTYQQLAMSRVRAVEHGRALVVAATTGVSAIVTADGVVRQQTTKFVPAALEATLPLRSDTTPATAMGPLPERMLCILAAAVALVAAIRRRTMRSAHRTDEDVTGDPAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYN1</accession>
    <name>A0A231GYN1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41716">
        <property type="protein sequence ID" value="OXR41716"/>
        <property type="gene ID" value="B7C42_06058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="18101" checksum="4F6ADE707EED4EDB" modified="2017-10-25" version="1">MMDSDDFGCGILLLGGQRGLEAVGFDVHDHHVDRVGQGSHVLGVQILHPFVAEVDLHTRNPELGIDLSRQHGHFMPGRHQSLTEGQVQRAHPGPAPPPQLAAHQNSLSGEVEPDPMPDLALRQGLGRVEVDAAVHIGQSATQLLDGQSGIGVGGSASGVIQLGDQAVSAIGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYV6</accession>
    <name>A0A231GYV6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06053</name>
        <name evidence="2" type="ORF">B7C42_08151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000067">
        <property type="protein sequence ID" value="OXR39776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39776">
        <property type="protein sequence ID" value="OXR39776"/>
        <property type="gene ID" value="B7C42_08151"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41711">
        <property type="protein sequence ID" value="OXR41711"/>
        <property type="gene ID" value="B7C42_06053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18172" checksum="17EE37BB8DEF3600" modified="2017-10-25" version="1">MQFPHRRTQTVGHPVHDLGAVGVADGQDHAAVTVVRRGVVREQLYRRPTGEARGLGLDVAQLPARVEQIAQFLEFGPGEYRIGNPRLQIGTGAAQQGASARDTHRTLGDGMRGDLGPPLQEPPDVAGDRKPIRLVPHRERNTVGVADRVRVDPQQRVLPVGESELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZA6</accession>
    <name>A0A231GZA6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41851">
        <property type="protein sequence ID" value="OXR41851"/>
        <property type="gene ID" value="B7C42_06193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="9529" checksum="62531FB48940A20D" modified="2017-10-25" version="1">MVTLGVETDVLGLGLDEITEAERAEVLAAHPRPDFKNKILRAFRNGMADRPDTTFGTMNDDVLAHFDPAFVRQDFVDIIRNSAGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZE6</accession>
    <name>A0A231GZE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinone biosynthesis O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.222</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubiG_3</name>
        <name evidence="3" type="ORF">B7C42_05954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.222" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778988.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41970">
        <property type="protein sequence ID" value="OXR41970"/>
        <property type="gene ID" value="B7C42_05954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="25032" checksum="6CAD2F1C2761648D" modified="2017-10-25" version="1">MTTPGDFTFENAYQGESGPFSGAKPPWSIGEPQPELKALAEQGKFHGDVLDVGCGEAAISLYLAERGFTTVGLDSAPTAIELARAEAERRGLTTAGYEVADITSFTGYDGRFGTIVDSTLFHSIPADQRDAYQRAIVRAAAPGASYFVLVFDRKALPNPPEGFGPSPVTEDELRDVVAKYWVIDDIRPARIHGNDLPRDERSPVRFDNIRDEPGGRVSVPAWLLQAHLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZF9</accession>
    <name>A0A231GZF9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase type 2</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cphA</name>
        <name evidence="2" type="ORF">B7C42_05939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41955">
        <property type="protein sequence ID" value="OXR41955"/>
        <property type="gene ID" value="B7C42_05939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="32640" checksum="1085205A88E2CBFC" modified="2017-10-25" version="1">MTATGTPRLAEPVVQEVADGVFAYTHGHGGWCVSNAGVVAGPDGALVIDTLATEDRTRGLIEHVDRVAGGPARTVVNTHHHGDHNFGNHLFGPAAVLIGHDRIRAEMIETGLALTQLWPQVRWGDVRVTPPTVTFSDRLTLHVGDRRVELIHLGPAAHTTNDVVAWLPAEKVLFAGDLVMSGAAPFCLFGSVAGTLAAIRTLAGLGAETVVAGHGPVTGPEIFDHTIRYLEWIDRLALDGRALGLTPLGIALEADPGEFADLVDAERVVGNLHRAYAEADGAAPGAPLDVLAIFDEMVGYNDGRVPTCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H021</accession>
    <name>A0A231H021_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetone monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pamO_1</name>
        <name evidence="2" type="ORF">B7C42_05815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.92" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42216">
        <property type="protein sequence ID" value="OXR42216"/>
        <property type="gene ID" value="B7C42_05815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033776">
        <property type="term" value="F:phenylacetone monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="580" mass="63677" checksum="CF978B892B39550A" modified="2017-10-25" version="1">MSAGQRDDICPGAVPFPSVEGGEQVSGERYPTVTPETTSSTGNIRTGVDVVIVGAGIAGLYAIHRLRGQGLRVQAFEAGDGVGGVWYWNRYPGARCDVESVDYSYSFDDALQQEWNWSEKYATQPEILSYLEHVADRYDLRRDIEFRTRVTDIVLDETTLRWRVRVDSGAEVTARFVVLATGPLSNANTPAIDGLATFAGRLLHTSGWPADGVDLTGQRVGVIGTGSSGIQAIPHLAEQAERLYVFQRTPNYSVPAGNTPLDEETRRRQKAGYPERRRLSMASGGGSPHRPHPENTLEVSEQERHDAYEERWQLGGVLFSKTFPDQMVTAEANEPARRFWEQKVRAVIHDPRVADLLIPRDHPIGAKRICTDTNYYETYNRDNVELVDLRTTPIQRIDAAGVHTTDAHYPLDTLVLATGFDAMTGSVAKMNIVGRGGETLNEAWREGPKTYLGLGISGFPNLFNLTGPGSPSVLANMVLHSELHVDWVGDAIDFLDRRGAAALEARPDAVSAWVAECAERASKTLMPQANSWYLGANVPGKPRVFMPFVGGFGVYGEIIAEVAAADYKGFDVLDVPSERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H027</accession>
    <name>A0A231H027_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase YghA</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yghA</name>
        <name evidence="1" type="ORF">B7C42_05809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42210">
        <property type="protein sequence ID" value="OXR42210"/>
        <property type="gene ID" value="B7C42_05809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="25357" checksum="29F556401BC1A700" modified="2017-10-25" version="1">MTGPRRTMVVGASRGLGRGIAVAFARAGAAVVAVARTESALRELAAETPGIDIEVADAADPTVPGALLDRHRPDVLIIVAGAPPLMRPLHQHTWETFSANWNTDVRIAFHWLREALLTPLPPGARVIVISSGAAVQGSPLSGGYAGAKATQRFITGYAQDEARRAGTDITFTTVLPRITPATSLGLPAVRAYAARAGRSVQEYIEQMGQPLTPEIAGAALLELASAGEPATSCQLTADGLTALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H054</accession>
    <name>A0A231H054_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42235">
        <property type="protein sequence ID" value="OXR42235"/>
        <property type="gene ID" value="B7C42_05834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012195444" evidence="1">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="12685" checksum="DF34A3F0AF78FE70" modified="2017-10-25" version="1">MPNFTVRRVLTAAAISAAGLAAPAPSAVAQPSIYHPVITPCSQQFRTPLEPPRPGTEVYWSPFGTAGIVCYDDGTGLEHYYQRDPAGRWHDINELLPGQHFYVIFTSTVPDQATWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H066</accession>
    <name>A0A231H066_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor NicR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nicR_1</name>
        <name evidence="2" type="ORF">B7C42_05462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42263">
        <property type="protein sequence ID" value="OXR42263"/>
        <property type="gene ID" value="B7C42_05462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="16267" checksum="FA82B23AF5E688C3" modified="2017-10-25" version="1">MDDTPARLRGKPSWLVSKTAALAQRHIGEAMSAAGGRGYHFAILAALDEFGPASQVAIGRRCRIDRSDMHAMLTELESQKYVARQPDPDDRRRNLITLTAAGERRLHELDAALTAAQDEIFGGLTRPERDRLIRLLTRVLDRHGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H069</accession>
    <name>A0A231H069_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42257">
        <property type="protein sequence ID" value="OXR42257"/>
        <property type="gene ID" value="B7C42_05456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="164" mass="18536" checksum="8E363187A83A53FC" modified="2017-10-25" version="1">MAHIWVVVCLPPDAIDDVQTALTRALAPFEMYEQPAERSMWDTWRIRGGGEGAGFYVRPGYEDDPRLIHDTPNYRGEVLPTNRGECAGGPKALLDLTRKTLAWCDVLTLDGWWVEDSGVCWHKDEDENTSYEDEPDCPVPPRGNQNYLATLPEDTVLVRVYCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H096</accession>
    <name>A0A231H096_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42268">
        <property type="protein sequence ID" value="OXR42268"/>
        <property type="gene ID" value="B7C42_05467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="361" mass="38934" checksum="009E35EF0A45995A" modified="2017-10-25" version="1">MSFGPDAGAIRSFGSGLRLYRRVRNARSVLSAIIVLLAAASAIGCSRPMQGPDQAERDSWSRVIESAIQALPGVADASHTFQYHRYGDYSSGLDVRLKDDATAPQAEAVVRVMATQQLPPQYRGDSTVLKMVRMTDSYFASWRFGGDTTRKAEAANTWARVSASRPGAEIHWSDGGTFAANVEGPAEKVVVAASSGTELSSATAAMRKIAGEFPELAARDWTVASGYHDLSIVGSSLGPDSSTSRRTRFPSDSELELWEWLVTDQPFPYFADIRVYDPPGMGGRTLGVAILPPAGEVFSAEQAAQLAGQHLPRLARSGAVVEYTLRGHQRFGFEVLVGGCPDPGRKVSAEAEPFVRLYERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0H0</accession>
    <name>A0A231H0H0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42384">
        <property type="protein sequence ID" value="OXR42384"/>
        <property type="gene ID" value="B7C42_05584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT_2" evidence="2">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="25514" checksum="FA8ABF0EFC31171F" modified="2017-10-25" version="1">MRSTIPGFRPLAFAAVAAVALLSGCAGTDNLPPIPDGFPPGAGSPVPLIDLDAPGRSAEQLRGWAEGQSDALGIPTVALEAYGYAAEVMDRSRPDCGIGWTTIAGIARVESKHGRHGGSDLDADGEVRPPIRGIPLDGSPGVAKILDDEATARAGAPVYVRAEGPFQFLPETWQHWGVDANGDGRADPDSIDDASLTAARYLCASGGDLRTAQGWQKAVLTYNQSTTYMATVRTKAAAYSVGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0T1</accession>
    <name>A0A231H0T1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kynurenine formamidase</fullName>
            <ecNumber evidence="2">3.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kynB_2</name>
        <name evidence="2" type="ORF">B7C42_05260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778087.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42484">
        <property type="protein sequence ID" value="OXR42484"/>
        <property type="gene ID" value="B7C42_05260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011278876" evidence="1">
        <location>
            <begin position="45"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="28108" checksum="4159628BDF3122EB" modified="2017-10-25" version="1">MCAPRIVRIAHDSADFPAAPSRRALSGAAGLAALAAATAPVARAGTGTVVDLTHPVGPNTPMWPGNPPFAMVPVGWHALGGFDQNAIALWEHTGTHVDAPLRRASGGAAPGAFSVRDLVAPLIVIDISAKASFDVDATVTIDDIDAFERIYGRIPPRAFVAMYSGWERRLAHPAAFVNLDAEGTPHAPGFCAEAAEYLVRRRDIAGAGVDTLSLDHAADPDYGAHTAFLGGGRYGVEMVANLGSVPPTGATVVVGTPEHIGGTGGPCRMLALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0X9</accession>
    <name>A0A231H0X9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stage V sporulation protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">spoVK</name>
        <name evidence="5" type="ORF">B7C42_05285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42509">
        <property type="protein sequence ID" value="OXR42509"/>
        <property type="gene ID" value="B7C42_05285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000470">
        <property type="entry name" value="CbxX/CfqX_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00820">
        <property type="entry name" value="CBXXCFQX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="104"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="37866" checksum="1F690C8FCB227C1C" modified="2017-10-25" version="1">MSGGTQGSGSGFRMYRPGAGGSAGSDANHPETQVDSDPSEITLPDDATVDLSTDLAGKNVEDTLARLDAELIGLATVKKRVREIAALLLIDRARQRFGLQADRPTMHMSFSGGPGTGKTTVALRMAEMLHALGYIRKPKVHTVTRDDLVGQFIGHTAPKTKEALAKAAGGVLFIDEAYYLFRPENERDYGQEVIEILLQEMETERSSLVVIFAGYPDRMETFFSANPGLSSRVAHHIEFPDYTREELLAIAEVMVAQQNFRFGDAAAVAFDEYLAVRMARPRFANARSVRNAVDRCRLRQANRLVQEHRPLGKADLVMLTTEDIYGSSVFGDRAGATEEAPACPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1D7</accession>
    <name>A0A231H1D7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol oxidase</fullName>
            <ecNumber evidence="3">1.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">choD_4</name>
        <name evidence="3" type="ORF">B7C42_05453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42675">
        <property type="protein sequence ID" value="OXR42675"/>
        <property type="gene ID" value="B7C42_05453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="462"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="577" mass="62758" checksum="57BA2DC6B730996D" modified="2017-10-25" version="1">MEAARPFDVDVVIVGSGFGGSVTALRLVEKGYSVAVLEAGRRYEDADFATTSWDLRRYLWAPALGCYGIQRIHRLRDCFILAGAGVGGGSLNYANTLYKPGRAFFEDRQWAEITDWDAELTPHYDQARRMLGVVANPHTTPADEIIRSVAEDMGVADTYVPTPVGVYFGEPGVVSPDPYFGGAGPERTGCIECGECMTGCRHGAKNTLVKNYLGLAERAGAQIHSMTTVTALRPQDDGSWRVETRRTDRRIRRGTRHFSARYVVLAAGTWGTQRLLFRMRDTGVLPALSPQLGVLTRTNSEAILGAGRTRVDTGLDLTAGVAITSSFHPTADTHIEPVRYGKGSNTMGLLQTYLVDGGEAVPRWVRVLAIAATHPLRTVRLLRTRRWSERTLILLVMQSLDNSITTFTRRGLFGRRYTSRQGYGEPNPSWIPAGHEVTRRVADTLGATAGSTWPDIFGVPMTAHFIGGCVIGGDREHGVIDPYHRVHGYPTLSIVDGSAISANLGVNPSLTIAAQAERAASMWPNEGERDPRPPMDLPYRRVDPIAPVAPVVPASSPAALRLPIVEVRHTAAGGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1D8</accession>
    <name>A0A231H1D8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-responsive regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lrp_2</name>
        <name evidence="5" type="ORF">B7C42_05420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42642">
        <property type="protein sequence ID" value="OXR42642"/>
        <property type="gene ID" value="B7C42_05420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17950" checksum="86AF5989CB14360C" modified="2017-10-25" version="1">MLTRVLDELDTALLTLVQQDARLTNKELAARLHVAQSTCLERIRRLTKRGILRGEHADVDLKQIGRGTQAMVAVQLRPPDRAVIESFQGFVANLPEVLSYFVMAGGDDFLLHVAVADNDQLSAFILDRLTQRREIVHVRTSVIFSHVRRTVVLPLEGAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1R7</accession>
    <name>A0A231H1R7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42793">
        <property type="protein sequence ID" value="OXR42793"/>
        <property type="gene ID" value="B7C42_05131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="19926" checksum="7660BE30F8E69C19" modified="2017-10-25" version="1">MSTASESDTGDSTGEAAGTLSRPRAALSWLRGHRAGVGAGALGALAVASVAAATGLYFTQYRPDQQTDEAAQHAATAAATDGSVAILSYAPDTLDHDLTTAKSFLTGDFLTYYGQFTQQVVAPAAKQKSVKTSAAVVRSAVEQIRPDSAVVLVFINQTTTTSDKPDPSMTSSSVKVSLSHVGGKWLISSFDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1S3</accession>
    <name>A0A231H1S3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_05129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42791">
        <property type="protein sequence ID" value="OXR42791"/>
        <property type="gene ID" value="B7C42_05129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012240631" evidence="2">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="122"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="373" mass="39094" checksum="3C2D750F933B074E" modified="2017-10-25" version="1">MIARLLVLCACALVTVTGCGWRGVDSLPLPGAPGRGSDAATYHVEMANVGTLVSNSPVMIDDVVVGSVGSITVHGWHAVVDVSVKPDVVVPANVAATIGQTSLLGSTHLALNPPAGQAPSGRLQPGATVPLNRTSTYPSTEQTLASLSVVLNGGGMGQINDIIHNLDAAFSGREGAIHDLIARLDAFMTVLDQQRDNLLATVTGLNRMAETFARQRDTVSDTLRRVGPALEVLLTERPTITTALDKLRTFSDTATGVISQVQADLLSNLHNLEPTLRELADVGSKIDGAVSFLTVFPYGQYGIDHGIRGDYVNLFATIDLTVPRLRRELLLGTPLGDPNAVLQAMVGDPGYGRQTNDPLGAPVNPPDPNGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H283</accession>
    <name>A0A231H283_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42954">
        <property type="protein sequence ID" value="OXR42954"/>
        <property type="gene ID" value="B7C42_04840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="12013" checksum="403758548E9084BF" modified="2017-10-25" version="1">MTSAAPAWTCSICFPATPVTLPWKCAESLPVTANPLIVRENGRLWQGERFHKQVRVKHFRTAGIAMRRFVDGMYALRHFCASVQLVNLVGVRELLSTWGIGMRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2C1</accession>
    <name>A0A231H2C1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42995">
        <property type="protein sequence ID" value="OXR42995"/>
        <property type="gene ID" value="B7C42_04881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="21187" checksum="4F0C75DA190D2828" modified="2017-10-25" version="1">MAESQDARRKLVAGAADMIRRRGLNATSVRELAKYAHAPLGSTYHYFPGGKTQLATEAVTFAGDLTAMLLVRELDNGPVEGLRAFLRTWRKILVDNDFRAGCPVLAVSVEDLADAEESPREAAAATFARWTELLSASLRDYGAGDADAERIATLIVAAVEGSVAMCRAERSTRALDHIGVELETIIEAAIAEPRSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2S7</accession>
    <name>A0A231H2S7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43163">
        <property type="protein sequence ID" value="OXR43163"/>
        <property type="gene ID" value="B7C42_04585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="164"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="32263" checksum="C6E95EE63461FF36" modified="2017-10-25" version="1">MNPPPEHAHAVMHCNLNTVDQARAEAYYTTLFEIAPRMRSTGKGVDATCMGMPSRTDSETVFLYDRRGPRAAPALELVEWQTPATVAPTPPPGAPGLTAIGYRVPSLSRIRGHLAESGHDPVEVAGGSMVRGAHRPAVRLRDPDGVVVELVEIEHAPSDPQSALISHERLSCADLSASLRWYSRIGFAARARGEGWISLVLPPDPTFSLELDQAPAGGATPQRTANTQGLYRIALAVDDVRAAYAALAASGHPGLQQPSFIPMPDVPTGGFTVLFLADPDGVVVELVERPRTEVRRPAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Z5</accession>
    <name>A0A231H2Z5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_18</name>
        <name evidence="9" type="ORF">B7C42_04652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43230">
        <property type="protein sequence ID" value="OXR43230"/>
        <property type="gene ID" value="B7C42_04652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="43254" checksum="621964118DA15D26" modified="2017-10-25" version="1">MDLDFTKEQLEFREEVRTWLREHKPTEPRPRDHAGIREFDLAWQRTQWDGGWAGIAWPREYGGGGLTLLQQLIWYEEYAAAGLPGIDANFVGLSHAGPTLITRAAQEHKQFHLPKILRGEVVWCQGFSEPDAGSDLAALRTRAVLDGDEFVVNGQKIWTSFAACADYQELLVRTDASGSKHQGITWLICDMHSPGVEIRAIETIEGGADFCEVFYDNVRIPVSNVVGEVGDGWSVAMSTLSFERGTAFTANQVRLAKVVEDLIEFARDHVGPDGKRPAILDDEIARRLATARASVTSLRAMTYAGICRAMQTETPGPKGSMLKLFYGDLAKQVGALAMDIVGPDALRRTSRWDRHGWVGNYFYSFSQAIGGGTSEIQRNIIGERVLGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3E4</accession>
    <name>A0A231H3E4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="2">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabH_5</name>
        <name evidence="2" type="ORF">B7C42_04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43347">
        <property type="protein sequence ID" value="OXR43347"/>
        <property type="gene ID" value="B7C42_04770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="1">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="32150" checksum="ED0917C5E1F1AA6C" modified="2017-10-25" version="1">MRVFMTGIAHTTGDPRPITGIEPIAAEPGLLDALHEVGLSTYRHARDSPINMAATCIAETLDQGRTPASGIDILMLASSTIGFGQIENTELLQLSERFGLAHATPIGVSAAECANFGTALHLARTLVTTGEARTVLLVTTDACTTPEQRLLRQVNSVVSDGAASCLVTTEPARIEILATATATNQLIRAATNPDTIAALNRRTLIGLADEVLLRANIDRAQVRQVITNNINTEALRFMTLSAGLDHNLCYVDNVADFAHVHSADNLINLQSYLEDGTAPDQIVLTISHAFGTWALAPLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3X8</accession>
    <name>A0A231H3X8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ORF">B7C42_04409</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502667.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43541">
        <property type="protein sequence ID" value="OXR43541"/>
        <property type="gene ID" value="B7C42_04409"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="187" mass="20342" checksum="9321899061E1A25E" modified="2017-10-25" version="1">MADTSDFKNGLVLKIDGQLQQIIEFQHVKPGKGPAFVRTKLKNVLSGKVVDKTFNAGVKVETATVDRRDMTYLYHDGSDYIFMDGETFDQIGIDERTIGKGAGFLLENMTVQVATHEGAPLYVELPVTVELEVTHTEPGLQGDRSSAGTKPATLETGAEVQVPLFINVGDKLKIDSRDGGYLGRVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4A0</accession>
    <name>A0A231H4A0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YybR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yybR_1</name>
        <name evidence="2" type="ORF">B7C42_03929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43694">
        <property type="protein sequence ID" value="OXR43694"/>
        <property type="gene ID" value="B7C42_03929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="15412" checksum="71D634ACA11BDE29" modified="2017-10-25" version="1">MGSIEAMTSRQLRSADDADPTLEADVFARNCRSRPVLQNVASRWGALALVALREGPYRFSALRRRVDGISERMLSQTLQALERDGMIHREVQQTIPPRVEYTLTGLGAQVADQLYGLIAILEDNIDVISAAQDTYHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4E4</accession>
    <name>A0A231H4E4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trehalose transport system permease protein SugA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sugA_2</name>
        <name evidence="6" type="ORF">B7C42_03942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43707">
        <property type="protein sequence ID" value="OXR43707"/>
        <property type="gene ID" value="B7C42_03942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="31660" checksum="534922001E398103" modified="2017-10-25" version="1">MSSPRGRTGSAIRALPWIGPVIILIAAVVAFPAGYMIWTSTRDLSPYGRDRGFAGTANFRRLFGIEELGSVLAHTVVWVVAVVLITLVLSAALAQFLALDFPGRTLIRLAILVPWAASVVMTTSIFAYLLDPEVGLANRLLVDIGVLDRGFGFTKEPGPAFAVAIAVAVFVSIPFTTYTILAGLHSIPAEVGEAGRVDGASAWQRYRYLTLPQLRPAIAVATVVNIINVFNSLPILQVLTGSIAGFSADTTTTLTYKLIRQNQQLATAAALSVLNFALIAVIIAVYVKLVRPGAQAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H540</accession>
    <name>A0A231H540_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Linocin-M18</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lin</name>
        <name evidence="4" type="ORF">B7C42_04213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505546.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43974">
        <property type="protein sequence ID" value="OXR43974"/>
        <property type="gene ID" value="B7C42_04213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="28788" checksum="9C20D4C39A4D43AA" modified="2017-10-25" version="1">MNNLHRELAPITSEAWSAIEEEATRTFRRHIAGRRVVDLSGPHGTDYSAVGLGRTTVIDAPDQGVQARQRLVAPLVELRVPFTLSREELDNVERGAEDADLDPVKDAARKIAFAEDRAVFEGYPAAGITGIRAAVSNTPVTAPSDPRLIPEAIAQALSKLRLAGVDGPYSVLLSADLYTAVSETSDHGHPIRTHIERLIPEGEIIWAPAIDGAFVLTTRGGDFDLQLGQDLSIGYLSHDAESVQLYFQESLTFLVYTAEAAVPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H545</accession>
    <name>A0A231H545_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase DesK</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">desK_3</name>
        <name evidence="3" type="ORF">B7C42_04151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43912">
        <property type="protein sequence ID" value="OXR43912"/>
        <property type="gene ID" value="B7C42_04151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="191"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="386" mass="41665" checksum="F5C4800C94B7B45E" modified="2017-10-25" version="1">MREGLREFGRRLVGNDPDASPLMRVIGATLLAANLVFDHRDPVPAWLWAVLVAAYAGWLVFAVVESRYPRVATLALTWCALLSAAVVGPAPDISAFIMLCAAASVLAQQFRTGTRIILLGFAAEVAVLIAGCAVAGKDIGDTLTYVGVLVILLLLGLYRRLHRLRVRQTRLLLEQTRRAQDEHARAAALDERARIARELHDVLAHSLGALSMQLEVAELLLAERSDIPGALAHVRRSHRLARDGLIEARGAVAALRGDVPPLPDAVRELVESYRRDHRMTVELRCDGPARPVDSGAAVSLVRTLREALTNAAKHAPGRPVRVALVFTAGDVRLSVRNTLAERRTRDPLPGGYGLTGMRERIALAGGALSSGVADGEWVVTAEVPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H548</accession>
    <name>A0A231H548_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein LiaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">liaR_5</name>
        <name evidence="5" type="ORF">B7C42_04196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780959.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43957">
        <property type="protein sequence ID" value="OXR43957"/>
        <property type="gene ID" value="B7C42_04196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="205" mass="21682" checksum="4A9C346684F20EBA" modified="2017-10-25" version="1">MIRLLLADDHAIVRAGLRALLDSGEDITVVGEAATAEEAVAFCTTTHVDLVLMDLRFGPGKSGVDATLALRALPDPPNVLVVTNYDTDADILGAIEAGACGYILKDTPPPELLAAVRGAAAGESVLSPSVASKLMTRVRKPDTTLSAREIEVLRLVADGHSNRDIGKHLFLSETTVKSHLVHIYSKLGVRSRTSAVARARERGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H593</accession>
    <name>A0A231H593_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hexaprenyl-diphosphate synthase large subunit ((2E,6E)-farnesyl-diphosphate specific)</fullName>
            <ecNumber evidence="5">2.5.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hexs-b</name>
        <name evidence="5" type="ORF">B7C42_03670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.83" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44113">
        <property type="protein sequence ID" value="OXR44113"/>
        <property type="gene ID" value="B7C42_03670"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036423">
        <property type="term" value="F:hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="431" mass="45647" checksum="3571820A0FC9E027" modified="2017-10-25" version="1">MVRHAPRREPVRDGRPEESAGPPQPSPVQTQRLAGHILGTPDTPRRARYRLADTTNYLEVALSVGPASPARPAPNDSAALVRAVEQALTGFFAGRRELVVELGPVVISATAALEDFVLRGGKRTRPSFAWTGWLGAGGDPTGDQAESVLTACAALELVQACALIHDDIIDSSRTRRGFPTVHVDFEHRHRDRGWGGDSAHFGVSVAILIGDLALTWADDMVAAAGLDAAARARFAPVWAAMRTEVMGGQLLDVHGEAGADDSVAAALRINRYKTAAYTVERPLHLGAALAGAEPELIAAYREFGTDIGIAFQLRDDLLGVFGDPAVTGKPSGDDLREGKRTVLVAEALRRADATDPAAARLLRSSLGTDLAPEQVTELRDLITGLGAVDDVERRITELTDRGLGALAASSVTPEAGDRLRAMALAATRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5B9</accession>
    <name>A0A231H5B9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prpC1</name>
        <name evidence="5" type="ORF">B7C42_03583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44027">
        <property type="protein sequence ID" value="OXR44027"/>
        <property type="gene ID" value="B7C42_03583"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_17" evidence="4">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="42484" checksum="E478A213C60F2E0F" modified="2017-10-25" version="1">MEWMDTAEATERLGVKPATLYAYVSRGVLKRRYDPVRRRSLFDPAEIEELARRGKPRRKPAPTEIDIVSRITTLGTDRPYFRGRDAVELAASHSFEAVAEWLWDGDLVDSGPWESSEKAVATARATQAGLPGGLLPIDRLQLIVTTLSVGDPLRFHRDRATVVTIARTVIAGMIEALPQLSVPVGRSAAAMLWSRLSASAPADDDELRILCAAMVLLADHELASSTFAARIAASAHADPYAVIGCGLGVLGGPMHGGASLAVERMLADITDPRSVPKALDERLRRGERIPGAGHAVYRSGDARGTYLVDAIRALAPEHPARLVAEAISAELRHRRLPAINSDFGLGVLAAVFGMVPGAGEIIFAVARTAGWLAHAMEEYESGTLIRPRAVPRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5C0</accession>
    <name>A0A231H5C0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F420_oxidored domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44045">
        <property type="protein sequence ID" value="OXR44045"/>
        <property type="gene ID" value="B7C42_03601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="24958" checksum="6660D033E62F98C1" modified="2017-10-25" version="1">MRIRITILGTGTLAEALGRRWAHAGHEITVSGRSVEKAQQLAQRLGAGARAVPLAEIAAVPADGHFAPDAEAATDTATAAGDTGAAGTADAVLLAVAYTGVEEILRAVGAPGGALSGLTVIDATNAIDHGVGVLRVPPGTSHAQRVGELAPGARVVKAFHLFPSEQWAAAESADTGTTHLPPSVTICGDDPAALRTTEQLVRDVGAVPVVLGGLDRARQLEEAAGFVISLAFSGVDPSRAVPAMPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5J6</accession>
    <name>A0A231H5J6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Cytochrome bc1 complex cytochrome c subunit</fullName>
            <ecNumber evidence="3 11">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">qcrC</name>
        <name evidence="16" type="ORF">B7C42_03646</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Binds 2 heme groups covalently per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 11"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44090">
        <property type="protein sequence ID" value="OXR44090"/>
        <property type="gene ID" value="B7C42_03646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009152">
        <property type="entry name" value="bc1_cytC-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000007">
        <property type="entry name" value="Ubiq_cycred_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="15">
        <location>
            <begin position="71"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="15">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="12">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="12">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR44090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="30350" checksum="955DFC0AEB88EA33" modified="2017-10-25" version="1">MSSSPPSAPDPTSGIGSAENNQAIKTRKQRRMRRKLAGGLVLLMGLVGAGFAASALTPHAQVATANEDQSALIREGKQIYETSCITCHGANLQGVQDRGPSLIGVGEAAVYFQVSTGRMPAAGNGAQIQRKPPKFDARQTDALGAYVAANGGGPTVVRDPNGEIAQDSLIKGADLGRGGELFRLNCASCHNFTGKGGALSSGKFAPPLEPANAQQIYTAMLTGPQNMPKFSDRQLSPEEKRDIVAYVKDRTETTPEAGYGLGGFGPATEAIAIWVAGIIVLVGAAMWIGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5L6</accession>
    <name>A0A231H5L6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">lspA</name>
        <name evidence="10" type="ORF">B7C42_03710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44151">
        <property type="protein sequence ID" value="OXR44151"/>
        <property type="gene ID" value="B7C42_03710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="25372" checksum="255CE34DB63852D1" modified="2017-10-25" version="1">MNTDRPREQHLDDPDEPPRESAADRGADRDDESGARDDGAGSDPAAGGSDAATPGEVGTNGTAPAGSAAGPSGAPAAFPRRLPWLLLIAAVVLAVDLGTKALVVAKMTPGEPISIIGDVVRLTLIRNSGAAFSMATGMTWLLTLIAVAVVIGVIRIGRTLRSLSWAIGLGLVLGGALGNLVDRLFRSPGPLQGHVIDFIAVTKWWPVFNVADSSIVCGAILLVVLTVFGFEPDGTRAGHEDDGKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Y4</accession>
    <name>A0A231H5Y4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplT</name>
        <name evidence="8" type="ORF">B7C42_03832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025348785.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44271">
        <property type="protein sequence ID" value="OXR44271"/>
        <property type="gene ID" value="B7C42_03832"/>
    </dbReference>
    <dbReference type="GeneID" id="66721504"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="14125" checksum="2FBA0CCFBE7A0FC5" modified="2017-10-25" version="1">MARVKRAVNAQKKRRSVLEASKGYRGQRSRLYRKAKEQQLHSLTYAYRDRRARKGDFRKLWIARINAAARLNDITYNRFIQGLKAAGVEVDRKILAELAVSDAEAFAGLVAVAKAALPEDVNAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H637</accession>
    <name>A0A231H637_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azoB_6</name>
        <name evidence="2" type="ORF">B7C42_03866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777665.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44305">
        <property type="protein sequence ID" value="OXR44305"/>
        <property type="gene ID" value="B7C42_03866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="30689" checksum="88A89BA7512E06AE" modified="2017-10-25" version="1">MIVVTTPTGSIGHQVLDLVADSDQPIRVIARDPARLAPHIRERVDVVRGSTTDRDVIAAAVKGADTVFWLVPPNPSAPSVPGHVLEFVTPLCEALDSVGRVVAVSSLGRTGGRKAGQISAIFAMDALIESSGVHYRSLCPPGFMDNLLRQVDPIRNLGTFFGTISGDFRAPTCATRDIAAVAARLLLDESWTGQDSVEIRGPEELSHNEMARIMSEVLGRSIGYQQVPAADYAASLTAHGMSAAWAQGLVDMSAAVENGLYDTPRTPESYSPTGFRQWCAEVLAPAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H642</accession>
    <name>A0A231H642_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44364">
        <property type="protein sequence ID" value="OXR44364"/>
        <property type="gene ID" value="B7C42_03152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="13687" checksum="FBEFE16269EBA02E" modified="2017-10-25" version="1">MTAGGLVRTAMAPAACRCRGCDGGATVTACLALTALLVVTVVIVQFAAVVCARHLAQSAADSAALAAAGALDSGAEAACEQADSVVRRMRMRLRTCSIRDWDVTVTVDGSVTVALLGKRSVAAVARAGPVSAVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6E8</accession>
    <name>A0A231H6E8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-[acyl-carrier-protein] dehydrogenase MbtN</fullName>
            <ecNumber evidence="7">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mbtN</name>
        <name evidence="7" type="ORF">B7C42_03898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782868.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44337">
        <property type="protein sequence ID" value="OXR44337"/>
        <property type="gene ID" value="B7C42_03898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="234"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="41605" checksum="C5ED37420F072AEA" modified="2017-10-25" version="1">MTLETALPTAGDLGRIVQDALDSVQADPALVRFPRQLLESLGKAGVLRSRWSADAAPGTDAGDVVFGVRLGAELSSRAPAGVAIGVSLHTETVLSLLHRFGHSDYLVALREQALDGTAVGCIAASEPTGGSDLSAVTCLATPTEHGWSVTGRKKFVSLGAVADFAVVLCRIAAADGRPTDRHATIVVPMTAARILREHDKLGTHALDTVAVEFDGAEVDRQATLGRAGLGVLNLNYGLSFERLAIAAQVAGGCATAISLAVEHAGRRTQFGKRLREHQYIAFRLAELSAEVEVLSGAVDTIARDLMAGPLDRALISRIAAVKLCAARAGERLISEAMQVFGGPGYLPRETPFGQFWNDIRVARIGAGTDEMMLAIITDSLHGNPDLYDRLVSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6U5</accession>
    <name>A0A231H6U5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator RcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rcdA_1</name>
        <name evidence="6" type="ORF">B7C42_03355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44565">
        <property type="protein sequence ID" value="OXR44565"/>
        <property type="gene ID" value="B7C42_03355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="25757" checksum="3C4EA65A83CDAD04" modified="2017-10-25" version="1">MITATTPKGERRRQALVAAAAELLLEGGFDAVRHRSVATRADLPLASTTYYFESLEDLIARAVEFSGNAELESMRRRIGEVTHRKRGAEATVDLVVDLMVGTDGPDEFARGRLIARYERSVASARHPELREVQLRLRAQLEDLLADVLRRSDRMVRTDQLRRLVAVVDGAVVAALAESDPQPRRTARGALLELIDVIAPPVPQPLMAPQTVPSAAAQHLPAAMPQQPSRHRTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H708</accession>
    <name>A0A231H708_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase YngG</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yngG_2</name>
        <name evidence="4" type="ORF">B7C42_03295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44506">
        <property type="protein sequence ID" value="OXR44506"/>
        <property type="gene ID" value="B7C42_03295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31311" checksum="D1C785ED747C9029" modified="2017-10-25" version="1">MTAVDIREVGPRDGLQIEEPIPTEAKLAFIDALVATGVRRIEATSFVSPRAIPALADAEAVAAQLHRWPGVEFSALVAGLGGVGRALAAGVHRLEYVVSASDGHSRANVGRDSAESVALIEPIAEQVHAAGGRLEVIVAIAFDCPFDDRTPPERVAEIAARAVASGADSLAVADTVGTASPVRTADVIDRVRAAAPDTELGIHLHNTRGQGLANAWTAYEHGVRRFDSAAGGLGGCPFAPGASGNIATEELVYLFSDGGIETGIDIDRALDAARLISHLLGKPVDSNLLAAGGRLRPRNAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H762</accession>
    <name>A0A231H762_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_03493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44699">
        <property type="protein sequence ID" value="OXR44699"/>
        <property type="gene ID" value="B7C42_03493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="236"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="462"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="270"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="499"/>
            <end position="506"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="759" mass="78625" checksum="563AAD1C0C7253F8" modified="2017-10-25" version="1">MTAPPSAGAEPRIAHGPLRPVELATAAVLGGVTVGLVTIGSVVPYAAALNLVAAVPMGLLAQRYRLRAILGATVAATLVSFVAAGLVPAATVVSAATIGGIIGTVKRRHRGLITVLCLSSLAGFIWAAFSVGMLFLFAASRRLVFDNVRNIAQGIDHMLSRQPQLESLGNGVVSVTDGVLAWWWLYIGGGVFLGVVFTAVFSWFVLGSVLDRLEWLPGRDRLDAPADTRAVAPVPVRLRGVSFRYPGARADALTDIDLSVEIGEFVAVVGHNGSGKSTLTRLLAGLPPTGGTVERPGSAGLGVIGGTALVLQRPESQTLGVLVADDVVWGLPAEAARAVDVEALLCEVGLSGLGGAETTTLSGGQQQRLAVAAALARDPALLVADEATSMIDPDGRRELVALLAGLPARHRMAVVLVTHHEADAAAADRVIHLSGGRQVEHLPAWPRPVRNPRRCPIGEPLLELRDVRHTYNRGTPWAATALRGVNLTVHRGETLLVVGGNGSGKSTLAWIMAGLVVPTTGSCRLCDYTGSRPVHKRIGAVELAFQHSRLQLQRQTVGAEIEDWGGHGTGSGAVGRALDAVGLDRAMASRSIEELSGGQAKRVVLAAIVASRPQVVVLDEPLAGLDPQGRAEVVELLARLRDSGLTLIVISHDVADMESVCDRTVHLQSGLILESLPAVAAAADSPADTAGAPAASPGPAEPVVGPPADGDGRGEAGITGTRSEPVQAGTDGARPEPDRARGRKRHSRGRHGDALGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7B8</accession>
    <name>A0A231H7B8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor-type histidine kinase PrrB</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prrB</name>
        <name evidence="5" type="ORF">B7C42_03476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44682">
        <property type="protein sequence ID" value="OXR44682"/>
        <property type="gene ID" value="B7C42_03476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="241"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="460" mass="49169" checksum="A72FA573A736DD97" modified="2017-10-25" version="1">MTAPGRRRFGLRHSYSLRTRVAGAAALGAIIITAVLSWVSVVALGRNNLAQADQELNIASRIVLMQPLIAVGVLSLVTPNKDMAVTVRDHGEIIASTSVRLPAEDPGSHTVTLDGTPFRVLTTTENQPEGRTVSIAIPLTNAYHTMSEQRRWVLFAAGLAVAAAAGLGWVFGGGAVRPIRDLTRQVSARSGTSTAEVRVDGSGVWEAEKLSEAVNSLLERVQFAQAETAAALETARDFAAVSAHELRTPLTAMRTDLEVLRTLDLDEQQRAEILDDLQRSQGRVEATLAALERLAAGELTDERDHVETDVGDLVDHAAHDAMRHFGDLTVRIETDPELITRGLPTGLRLAVDNALTNSARHGGATQALVSAHRRPDGWIVISVDDNGAGIPAEERRTVFDRFIRGANATKGGSGLGLALVAQQAQLHGGRAYFDDGNMGGVRLVLELPDRPMSAPPPPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7H0</accession>
    <name>A0A231H7H0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783354.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44874">
        <property type="protein sequence ID" value="OXR44874"/>
        <property type="gene ID" value="B7C42_02828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011301474" evidence="1">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="15119" checksum="310521643C962A2E" modified="2017-10-25" version="1">MSRSSARRALFALVSGGGIALTSAALLATPAQADSTSCPAPGATSVADTGADAACSATSTGGSAAAAYGINGTASANAGPTSLSLAIAQGGGTARSASGPWSGPAAIAVGSGATADLSGVRPGLAIGIAGPGATVTVSGVGTPVCTGGPGFAGDFQTFQGCLSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8B8</accession>
    <name>A0A231H8B8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">27-O-demethylrifamycin SV methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.315</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.315" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779972.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45032">
        <property type="protein sequence ID" value="OXR45032"/>
        <property type="gene ID" value="B7C42_02989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="325" mass="36144" checksum="49293E880C15D8E7" modified="2017-10-25" version="1">MTARLDDPAPNPHATEAEVQAALTDNKLAQVLYHDWEAETYDDKWSISYDERCIEYARGRFDAVAPNAPLPYERALELGCGTGFFLLNLMQAGVAKTGSVTDLSPGMVKVATRNAQNLGLDVDGRVADAETIPYEDNTFDLVVGHAVLHHIPDVEQALRECLRVLKPGGRFVFAGEPTTIGNFYARKLGQITWKVTTEVTKLPFLSDWRRPQAELDESSRAAALEAVVDLHTFDPSELEQIARSAGAVQVHAETEEFAAALWGWPVRTFEAAVPEEKLTWRYRMAQYKAWLGLSKLDEKVLRHVVPRQFFYNAMITGVKPGAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8K0</accession>
    <name>A0A231H8K0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene desaturase (Neurosporene-forming)</fullName>
            <ecNumber evidence="2">1.3.99.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crtI_1</name>
        <name evidence="2" type="ORF">B7C42_03126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.28" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45168">
        <property type="protein sequence ID" value="OXR45168"/>
        <property type="gene ID" value="B7C42_03126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="220"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="515" mass="53649" checksum="300FC3F7078991A8" modified="2017-10-25" version="1">MPDVIVIGGGHNGLTAASYMARAGHSVTLFEATGSIGGMTATRALVPEAPNHLISPCAIDAVYWRASTVERDLELGRYGLRIIDHDPAWAWLGPNGESLLLARDVARTIAEIERFSTEDARTYREFAQTTAKMLALQDGFGAGSPNRPDRETLLAAVRGLANGKVRHLLGAALTTSAADLIESTFVSEQVRGAFAAMASILGSITVDSSGIGLLATAPLHRDGVARPVGGMQAIADSLSECLRAHGGTVQLSSPVDQILVSGGRARGVRLANGEEVIARMVIAAVPPQVTARLLAGSAVPGVEALGHAPSNSAGIGCLVIGMALRGTLNLGDHQRNRHDGVDLRKPTLFYGTLEHVLAGESQARVAQPVTDPPWTATILSATDPTQAPDGQDNLYLYAPTPVRPEGGWGATRASAEKELVGAVEKAVTGISELEIGRWVETPEDLEHRLGAANGCIYHVDQVVTRLGPLRPARGWGKHATDVPGLVLSGAGTHPGGGVSGIPGQLAARAALRSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Q1</accession>
    <name>A0A231H8Q1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor Bm3R1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bm3R1_2</name>
        <name evidence="6" type="ORF">B7C42_03034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45077">
        <property type="protein sequence ID" value="OXR45077"/>
        <property type="gene ID" value="B7C42_03034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22632" checksum="BD48477F195CD167" modified="2017-10-25" version="1">MTSASPGLRETKKQQTRQEISDTATGLFIERGFEATTIAEIAEAARVAKKTVTNYFPRKEDLALDHHEQFVGALAAAVTARAANESALDALRRLFRTGTQDHAADLGFSGPEFSRMLADSPTLTARVRELHELREQALAEVLPGDDLLRRAAAAQFAAACRLLFQRIQQLQLSGASRHHVAATVTAEAERIFDLLEPAFGEYGRASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9A7</accession>
    <name>A0A231H9A7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent curcumin reductase</fullName>
            <ecNumber evidence="3">1.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">curA_2</name>
        <name evidence="3" type="ORF">B7C42_01895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783983.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45603">
        <property type="protein sequence ID" value="OXR45603"/>
        <property type="gene ID" value="B7C42_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="16"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="36970" checksum="2AA34C9011A3987C" modified="2017-10-25" version="1">MGHKTTQIRLTSRPVGEPRDSDFEVGTAELSELIDGQVLLRTIYLSLDPYMRGRMSAAESYAEPVELGAVMIGGTVCEVLESRSPNRAPGDLVLAFTGWQTHAVVPARQTRRLDPAEAPISTALGVLGMPGLTAYAGLLDIGKPEPGQTVAVAAASGPVGSAVGQIAKLKGARAIGIAGGPVKCRALIEEFGFDAAIDHRSPTFRADLEAATPDGIDVYFENVGGPVTEAVVGRLNPFARIPVCGVVSGYNRTETSAGTDRLDLSAVLWQILTRSLSVRGFIVEEFVPTRQADFLRDMAGWVAQGSVRYREDIVDGLERAPEAFRGLLAGRNFGKLLVRVGEDPTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9J5</accession>
    <name>A0A231H9J5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776526.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45472">
        <property type="protein sequence ID" value="OXR45472"/>
        <property type="gene ID" value="B7C42_02597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="98" mass="9913" checksum="95346372ECE2A79D" modified="2017-10-25" version="1">MEFDPVVAARTAADLDALADRLEAGLQADAPALSVAAPGVDEVSRRAATTLTEVGASFGSSGNLGVQELRKLAATLRAQSRGLSRMDSDNAADLGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9K3</accession>
    <name>A0A231H9K3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">drrC_2</name>
        <name evidence="10" type="ORF">B7C42_02636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45511">
        <property type="protein sequence ID" value="OXR45511"/>
        <property type="gene ID" value="B7C42_02636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="28641" checksum="BACD20D85B21C4F4" modified="2017-10-25" version="1">MSEMVMGDSPVLGTRIGDLGSQTLVETGRLLRRWSRQPEVITSTLVLPILLLLMYDLVLDKSLGATGGADPIYGFVPMIAVAGAMYGAMGTGMSLYAERESGLLRRFWVLPMHRWAGLSGRLVAECARAFAATIVVVAVGMALGLRFQQGWGGAIGVLLVPVIVIAGFTPLVVAVGVSSAGDKVVQLFAIVVLVGMFFNSGFVPVQNYPGWLQPIVRAQPMSCAIEAMRNFTLGGPLLVPMLQTVAWSAGLIVVFGAMAIRGYRRAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9W8</accession>
    <name>A0A231H9W8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036510003.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45658">
        <property type="protein sequence ID" value="OXR45658"/>
        <property type="gene ID" value="B7C42_01950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="59" mass="6660" checksum="86A65E29393ACCF2" modified="2017-10-25" version="1">MFTNIIQPLQQLAEQNRDVIGYVVINTGNAILGVVRWGFDAATPWLQQFFSEYPPGGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9X5</accession>
    <name>A0A231H9X5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45655">
        <property type="protein sequence ID" value="OXR45655"/>
        <property type="gene ID" value="B7C42_01947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="217" mass="24195" checksum="D897A13789CD44B7" modified="2017-10-25" version="1">MPREAPSSIGLDEAVELTRTGDLWLFRGHSGADRAIRGLTNSPVNHVGMAVVVDDLPALIWHAELGRALPDVWSGNHHRGAQLHDLQAAVLRWTNDYGQQAWLRQLDRPVTREMEDAALRTVARLDGMPFPSTSALAGRWFRGRIPLPKRSKPREAEAGLENAYCAEIVAMTYQAMGLLPEKRPNWYDPGRFWSGDNLHLSADYHLGGEIAVDVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA76</accession>
    <name>A0A231HA76_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator CysL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysL_1</name>
        <name evidence="3" type="ORF">B7C42_02145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45853">
        <property type="protein sequence ID" value="OXR45853"/>
        <property type="gene ID" value="B7C42_02145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="32237" checksum="F7B2E348A7CC0F34" modified="2017-10-25" version="1">MSLRQFEYALAVAEEGSVTAAAERLHVAQPSMSQQIRTLERELGVTLFDRTPTGLVPTVVGRAFLRDAELAVTAARRARATARAGADDLVGELVVAAQMGLGTRQLPNALGVLRRRFPRVAVTVFEEPNPADLERMARRGVLDLALMAGPCGEGRYIGHHLGDEGFLVVLAEGHPLLAADRIELRDLEREPWVRFDQDGALDSLLRNVLRDNDIAPVTVARVSQTATAVRWAAQGLGVTLVPASAVPHDHCHLARPVSPGVYQPVVAAVRPGAGPAETALLELLRRENWCRTAHPAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA81</accession>
    <name>A0A231HA81_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadK_1</name>
        <name evidence="3" type="ORF">B7C42_02156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782426.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45864">
        <property type="protein sequence ID" value="OXR45864"/>
        <property type="gene ID" value="B7C42_02156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="51"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="420"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="517" mass="56137" checksum="191577C38F5BE2E1" modified="2017-10-25" version="1">MRKIPQQLVDRYEARGWWTRESLGEMLARGLAGAPEVPFRVHSQLRPWSGTVREVEHIARRLAAGLRRRGVGPGDVVAFQLPNWMEAAATFWAASFLGATLVPIVHFYGRKELGYILDAVRPKVFVTAERFGALEFQPDLCARVPIVGVVGRDFDTLLDDEPMPGIVTVSPDSPALIAFTSGTTRDPKGVVHSHRTLGFETRQLSAHYPPDLGAQLTAAPVGHFIGMVNALLIPVLDGTEINLVDVWDPGRILALMSEFGATVAGGVPYYLTSLLDHPSFTDAHLRQMKYAGLGGSSVPAAVTTRLTDLGIIAYRAYGSTEHPSITGSDCTDPQDKRLYTDGCPLPGVEIRLSDAGEIYSRGPDLCLGYTDAELTATAFDDEGWYRTGDVGHLDEDGYLTITDRTTDLIIRGGENISAVEVEDVLHRMPAVAEAVVVAAPDARLIEHAAAVVRLRPGSTTPTLADVQAHLAESGLAKQKWPEELHIVDDFPRTPSGKVQKYRVRAAVAGRDVATRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAF9</accession>
    <name>A0A231HAF9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45815">
        <property type="protein sequence ID" value="OXR45815"/>
        <property type="gene ID" value="B7C42_02107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="20466" checksum="512339225C45188A" modified="2017-10-25" version="1">MSRWEPNARGRLSAAALELYTERGFDETTVAEIAERAGLTERTFFRHFADKREVLFGGQDLLSSAIADAVAAASADADPMATAIAAIQAAGGRIPDLPVWQRQRRAVIAANPGLQERELRKMAVLGGELVDALRAAGASEAVATLCARLAVTVFGIAFDRWLDGSSTRELSHVIAEVYAELRDAVGAGGAVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAK9</accession>
    <name>A0A231HAK9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45869">
        <property type="protein sequence ID" value="OXR45869"/>
        <property type="gene ID" value="B7C42_02161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="17227" checksum="98DAF63B8ED6FF5E" modified="2017-10-25" version="1">MAVPTIGGMRTAVIRVDVDPAGELPPAEFGKKISALISSAAKSGISVTAPDIDRLPARRREIQVLIDGDDTAALLEHAVGMCADIFGSAVRPGAVTFVSRGTDDDAHGVLAGFGITGEIDRSCDAAGFDTLTVRLARTDLERIPESRIQTALEAATNSEVVIVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAL3</accession>
    <name>A0A231HAL3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45852">
        <property type="protein sequence ID" value="OXR45852"/>
        <property type="gene ID" value="B7C42_02144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="20876" checksum="282AA1ADE08BB0F5" modified="2017-10-25" version="1">MPERRRADARRNYALVLAVAEKEVAAHGAGASLEQIARVAGVGSATVRRHFPTRRALLEAVSRTRIDALCARAHELAAAEDSRGALLEWLRDVVAYCVGARGLAVALSYDSAGADPVHDNSCGAALEEAGEPLLRRAAREGVVATTFTVADLITLIVGIALATEHGADPGAQADRLFGLVVAGLSPQQAPADARVQAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAN8</accession>
    <name>A0A231HAN8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_12</name>
        <name evidence="1" type="ORF">B7C42_02174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778156.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45882">
        <property type="protein sequence ID" value="OXR45882"/>
        <property type="gene ID" value="B7C42_02174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="26056" checksum="BEFFD7F7081C7B2D" modified="2017-10-25" version="1">MSEDLLGKGALVSGASRGIGYAVAAELLRRGANVLITARKPEPLAEAADRLRALGHPGTVVALAGNSGDEAARAEQVDTAVAEFGSLDILINNTGINPVYGSLMEADLGAVRKIFDVNVVAALGYVQQAYRAWMGEHGGAVVNLASVAGIRSTGVIAAYGASKAALIRLTEELAWQLGPSIRVNAVAPGVVKTKFADALVTDNEEAVAATYPLRRLGTPEDVAALVGFLVSDQAAWITGEVVRVDGGLLATGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAP4</accession>
    <name>A0A231HAP4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45806">
        <property type="protein sequence ID" value="OXR45806"/>
        <property type="gene ID" value="B7C42_02098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="17093" checksum="5786EA25E92EE5C8" modified="2017-10-25" version="1">MVAPTVTEVVRCAGGWLFDRGMAGWEVTVIVGDPTHARALEILGAVVLDMEDSLSSPVHGPHPHAVALAGELFETDHRIRCGVLDTLDRGLSEVTLLGEFCPSELDCRVDTVQHRLSVAARAFKRQALAAAGIPATAVAPLETFRSGAPVWAPPVDLVPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ9</accession>
    <name>A0A231HAQ9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45826">
        <property type="protein sequence ID" value="OXR45826"/>
        <property type="gene ID" value="B7C42_02118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="19653" checksum="C7F144BF6C701B16" modified="2017-10-25" version="1">MTEQRRVNRGPGAAAANRAALIAAAREVFAESGFEAPLNLIARRAGVGQGSLYRHFADRESLALAVFEDNVVGLEAYAAQSDTGLDQLLERIVDQVVTSIAFVELIDPSLTDGRLVRMSSRVAALLGDHLDTARACGRVRADLTCQDLMLALAMLAALLARAGAQERRGLAARGWSLIQQGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB05</accession>
    <name>A0A231HB05_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46113">
        <property type="protein sequence ID" value="OXR46113"/>
        <property type="gene ID" value="B7C42_01078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22212" checksum="CA6ADB797212DF82" modified="2017-10-25" version="1">MPIALASLPTTQTTAIPEPAELDELLPVLAADNQPRLIVLGEDAGLAAVLTHLLRTERLAVEIGYVPVDRTYGSRAYQTGTGSHAAKRALEGRAEPTPLIRDETGTVLVGRATITGRDGGKLEGEAYVDEVRLFTGKVAALHVSPTLEMPGVRATVQRGWGKKRWVAGRAVQLGSPGAAVTRDGIAADRTVPRSSFYRHHEPWLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCW1</accession>
    <name>A0A231HCW1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsgA_1</name>
        <name evidence="3" type="synonym">rsgA</name>
        <name evidence="6" type="ORF">B7C42_01579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46608">
        <property type="protein sequence ID" value="OXR46608"/>
        <property type="gene ID" value="B7C42_01579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="103"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="111"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="198"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="38547" checksum="C510F6E2C606DD8F" modified="2017-10-25" version="1">MVDYDRLLPYGWTADLSAAYAGLLDTGWVPARVIRMDRSECDVATPDGLARASCPRADTNINGLCTGDWVAVAPADTSAGPAFTVRKLLPRRTILQRATVSGRSDAQVLATNVDTVAICVAADGEIDLGRIERMLALVWESGAQPVVVLTKCDLAPDVSLPDVRAAAPGAAVVPVSATTGAGMDVLRAVAAGTVALIGSSGAGKSTLANALLGEEVFATDRVRASDKRGRHTTVHRELRPIPGGGTLIDTPGLRAIGLWAAEQGLARTFTDIESLAAQCRFSDCEHRTEPGCAILAALGTGELPQRRLDSYRKLQRENERLAARSDARLRAERERVWRDITKSHRRMQKERDSRRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI5</accession>
    <name>A0A231HDI5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46825">
        <property type="protein sequence ID" value="OXR46825"/>
        <property type="gene ID" value="B7C42_01803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012917927" evidence="1">
        <location>
            <begin position="30"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="448" mass="48204" checksum="112DB59E78FD7FD5" modified="2017-10-25" version="1">MGRLRGWVIGVLVVVLIGGACATAVPARAEDPPTCAVSSGREFERATPESAGLDSARLASALRFADERNRLNVKVFRHNCLIGSGAHNDATDTTPWNIWSVTKSVVSLIAGIAWDQGKLDIDAPIDRYLPPGLGDAAHRAITVEDLLTERSGLRVGVINEGVSGVVPIDPNSAVQALGVPLDNPPGTRFSYSQRNVDLLSYVTELAVGEPLQQFAQRELFSPLGIQRGDYYWARDRSGHTYGYAHLMIPPDDLAKIALLVAGDGDWNGVRVVSADYLRRAQQTGPGRECYGYLFWARPGCIEIPSFLPPDVFAMSGLGLQDVFFIPSLDLTVVWTGVFGNRSTGGPTGIVQNLTELTWEFFRRLLGAFEQPPIADPGPYVEPPVTLDPRAFFDPDITLAVFGIGPDAYPGCTVLSCLQTPLAPPFSDAPPGCALLVCLGPDPRTPGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDR9</accession>
    <name>A0A231HDR9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46926">
        <property type="protein sequence ID" value="OXR46926"/>
        <property type="gene ID" value="B7C42_00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="20926" checksum="C3BC17C3E5C8D5A3" modified="2017-10-25" version="1">MFKLAKASAIKARTQTINQLKAVLISADPALREELTGLSNPVLFRRCAELPPTEPNDVTGTAIYTLRLLARRIRELTGEIRDLEQRITDAVAQHTPALLERPGVGLDSAAVLLITAGDNPDRLRSEGAFASLCGVSPVQASSGKTHRRRLNRDGDRQANAALYRITLSTDASLKAKLAARPSAASNAISHGRSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE17</accession>
    <name>A0A231HE17_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778118.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47018">
        <property type="protein sequence ID" value="OXR47018"/>
        <property type="gene ID" value="B7C42_00136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025350">
        <property type="entry name" value="DUF4254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14063">
        <property type="entry name" value="DUF4254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="180" mass="19544" checksum="4CC562DE3B448847" modified="2017-10-25" version="1">MATAYAGDNDATGALPSVSALLRAFRSTTPPPGDHPVLEAARELVRCHELRRHAYREAQAPKASSARVAGASRLVGHIDRDRTRLIECIDVWVADNIAHREGASLHTETLGAVIDRMAGKWVAAHHALGLPASNHPADELAASTPDGEAHLHWVRLAELADGYKDLITDIAEHRRRLPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEA9</accession>
    <name>A0A231HEA9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hprA_1</name>
        <name evidence="2" type="ORF">B7C42_00311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.29" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47189">
        <property type="protein sequence ID" value="OXR47189"/>
        <property type="gene ID" value="B7C42_00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:glycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="98"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="309" mass="32922" checksum="EE9D255463A76EE6" modified="2017-10-25" version="1">MTGAARIALAPLTSDFLEQAITGAGARLSELSDARALVWDGGPNGFPDLPESIEWVQLYSAGVEEFFDAGIFERHPNVVFTSAAGAFAKSVAEATMALLLAGVRYLPEHIRAHSWRQTEFFPHIGTLRGATVAVVGAGGIGREVIAMLEPFGARVIAVNRSGRPVDAPNVVETIPAERISEVWARTDHVVVAAPATDGTRHLIGKDELTQLKPHSWVINVARGSLIDTEALVAALREGAVGGAGLDVTDPEPLPDGHPLWDLPNVIITPHDSNPPQLRTAAFAEHVAANVTRFVQGRELIARIDPEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF70</accession>
    <name>A0A231HF70_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">drrC_1</name>
        <name evidence="10" type="ORF">B7C42_00725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47600">
        <property type="protein sequence ID" value="OXR47600"/>
        <property type="gene ID" value="B7C42_00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29024" checksum="3C39420E04835FA7" modified="2017-10-25" version="1">MTGAGTAVRELATVQVDTERWRYLLPQTLVQTGRLLRRWRRDPLTTAQILVFPALLLIMLNTVLGRQISSFSGVDALYGSVPMVTVVSVMSGSLAGAVTLGRERDAGLLGRFWALPVHRASGLLSRLLAEIARIVLCTVVLFAVGMALGFRFHRPAAAVAVLGVPLLYGIGFATMVTAVAVYSAKTFVVEAISLGSSLLMFFSTGFVPLPAYPGWAQPIVAHQPLSTAIDSMSALALGESARGPLWATVGWSVGAMVLFAVPAAVGFRRASRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF99</accession>
    <name>A0A231HF99_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47396">
        <property type="protein sequence ID" value="OXR47396"/>
        <property type="gene ID" value="B7C42_00519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012533931" description="GSDH domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="82"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="37285" checksum="744B0D5EF8D2F771" modified="2017-10-25" version="1">MSVVVVGRVASILAVTAGLVVGCARFDDSASKPFTPAPTIEPEGQGPTSEPKTPPPTGQRPTGPCIDPDPAVVVSCLDTTGGLTVLPDGQQALVTERTTGRVLKVTAVDPSQAPPQPLEVTRVDVDAAGDGGLSDVALSPSYGEDGLVYAYITTASDNRVVRIGAGGDPKPILTGIPKGANGNHGSLAFVSPTKLAVLTGDAGNPGAANDPGSLAGKLLEIDNPAPGNANPKVVASGIGTAGGVCPDHKDTIWFTDRTATEDRLQRLGPDGAVATAWTWPDKPGAGGCAAAVDGVAVSMSGAKALAFADADPTTHAVTTAPTMVAQDKYGSLGGAALGADGNVWVGTVNKPAAAGPLDDRIVRIPPPKGGAGGGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFD7</accession>
    <name>A0A231HFD7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47407">
        <property type="protein sequence ID" value="OXR47407"/>
        <property type="gene ID" value="B7C42_00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="342" mass="36355" checksum="83E7C534E399E69A" modified="2017-10-25" version="1">MTSEAIFLHRDDDIVTVSPAGAPTVHDTTPGLDTLVLEVIGGHLSWSLLSGHTLPAAVLHDPDAAQEWLWAVYGEPVALAVADGRSGELVATPARDELSDAARQLGYAQWAAHWWPASTIDGIPALDPDLLARDIAALTESCDLCVDGADALPWPVPPSEAVAPRRQDYALAAGPTDAGRTGLVLATGTSGWDWRRCPPGVVDASEFAVSWRLTRESGNTSVEVRVAAAPHLDAGMPGHLWPHARVVTDSAPTELALQLSGDTWVGGARVDAENVVRVDIYVPGVGPTPDETSVSASASENLYGPRQRQRIREFVIDRLRSPQPSMPLLEAERTAAASDTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG77</accession>
    <name>A0A231HG77_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47727">
        <property type="protein sequence ID" value="OXR47727"/>
        <property type="gene ID" value="B7C42_00852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="17218" checksum="65FA266DC315B18A" modified="2017-10-25" version="1">MTRPPTFTVGEFRKASASSPHQNCVRVARKHGWTAVWDDKRATAATTAGTAVIGTEILLLRDEQFDSYQAGIRAGRTERLPITQFRRPDGRYVLRAETGRPTADVELIFDRAELDAFHHGVRTHEFDLHRFTAPALDDTECDTRATGLTARIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG88</accession>
    <name>A0A231HG88_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpA_1</name>
        <name evidence="2" type="ORF">B7C42_00862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47737">
        <property type="protein sequence ID" value="OXR47737"/>
        <property type="gene ID" value="B7C42_00862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012691983" evidence="1">
        <location>
            <begin position="26"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="35988" checksum="00629D28CE51EFC8" modified="2017-10-25" version="1">MITRAALGAALAVAAGAMAAAPVCADPAAPPPAAPPAIDPAVTRTELVRTETRGPGWDRLYVASAAMHRVVPIDVLRGGGSEPRPTLYLLDGVEGAATSGWLTDGEAARFFAGKPVDVVLPGDGVGSMYADWDHYDQNLGLNRWETFLVDELPPIVEKFLHSDGRRAIAGVSMGAQAAMMLAQRHPGFYRAVAGISGCYSTADEVGQAVTRITVASRGGNPENLWGPPNSPEWVAHDSYLGADTLRGTPIYLSAATGLPSPPDLTAIATAHDVAGALRSAGGGVALEAGARTCTERFAARLAQLNIPATVRYIPAGTHSWPDFTAALPSAWDALAAGLGIARTWGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU95</accession>
    <name>A0A231GU95_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase 2</fullName>
            <ecNumber evidence="3">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778472.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40115">
        <property type="protein sequence ID" value="OXR40115"/>
        <property type="gene ID" value="B7C42_07823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011287138" evidence="1">
        <location>
            <begin position="30"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="39"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="30370" checksum="59082A582557B189" modified="2017-10-25" version="1">MSHRRPLGLLAAFSMLGLSAAVAPATADAATPHWGTYVALGDSYAAGPGLPEMEFAPCERSRHNYAHNLAEALHVDRLIDATCGGAVTDDFSRSQKPGAPPQFEAITPDTELVTVTIGGNDAGFSEVLGTCGALSLAPIVADPCHAYYTQTGTDALTDRLETDVAPKVRAVFDGIRARAPHATIVATGYPRLTPTAGSCFPALPFAPGDYAWINQVQDRLNAAIAEQARAAGIEYADLLDASAGHDACRDAQVRWVEPTLNSSSAPAHPNHAGMSAIAQVVANRIAQGFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUS4</accession>
    <name>A0A231GUS4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40318">
        <property type="protein sequence ID" value="OXR40318"/>
        <property type="gene ID" value="B7C42_07579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012489071" evidence="3">
        <location>
            <begin position="31"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="414" mass="41139" checksum="DF4612DD2D5D91FC" modified="2017-10-25" version="1">MRTVQTRTRIAALLAPVAATVLAVPGPAGAAPDPAGPGCPVLWVLGVQGTGQSSPDASRTDDTGMLGALLGPVTAAAGTSVQHTYIPYAAGFGGVVGAGGGEEPYADSVTDVITDLGVEAQRIVDQCPDTELALVGFSQGAQAVSQVARAIGAGNGPVAPDKVAAVALYANPERRAGGPVLAGRPGQSTPDPAPGTSGAAVSTVHLAAPSASGGGIADDGAEYGSLTGRVLDVCADGDLACSAPQHAAALRFGALLAAQADLSNPIAATDSLQAAMSQALGSAWTTVVLDDVVVDADTVDYRPQKSLSQRLIDAADPRVPAPGRDRVRAAADRWNQVTATVVSHPGELARLAGQLAGAVGQVAADNGDLANPEVWVRILGTAPIHEGYAVAGQLASGIAWLVAVAHDLADKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV15</accession>
    <name>A0A231GV15_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional activator RamA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ramA</name>
        <name evidence="5" type="ORF">B7C42_07407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780078.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40469">
        <property type="protein sequence ID" value="OXR40469"/>
        <property type="gene ID" value="B7C42_07407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="225"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="31001" checksum="BC000691699A4358" modified="2017-10-25" version="1">MAAADLLRPRDADALRAELRQVSALSGMPVVFGGEVCDGALILSEFFGTRTAAMRGLVVSPTSGVGGAAVASRRPTSVADYRAAATITHHYDAPVSMEGLRAVVGVPVVVDGSSRAVLYVASREPGPIGDRIAELVLRSSRRLAVELAVRDEVDRRLRLQAAARGNSEITTAPAPDTVVAEQLRDLHAEVRGIAQTLTDAEARKRLRAVSDTLVRLMGGSDDPVAADAAPGLSPRELDVLSYVALGCTNSEAAQRLSLRPETVKSYLRSAMTKLGAHTRHEAVVRARRCGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV45</accession>
    <name>A0A231GV45_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40351">
        <property type="protein sequence ID" value="OXR40351"/>
        <property type="gene ID" value="B7C42_07612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="3">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="416" mass="45401" checksum="B39838B7B3391A9B" modified="2017-10-25" version="1">MLPAGTAPSSVTVIMEPTRNAWVPLAAWFRRQGATVILVPPEQSADLRDYYCKHTKSDRLDSKVLARIPLLHPEGMHPATGLGPGDTMRRAVKLRSNLVKRRTGILARLDALLELLGPGWHAALGADLANKTPLRFLAHYADPHIVIRLGRARLTRFLARHSRGSWREEKADQLLAAARETLDLWSDELDFPELADDIAIEARLALQLTEEIKELETRIAALLDKADPDGIVSSTPGVGPILAAQILGRLGDPNRFDSLAAIRSFSGLVPKLESSGLSGRHGGPTKSGDACLREALFMAAEQARRSDPSLAAKYHRLMTDSGKHHNSAVCHLSTTLLTRIAACWRRGEHYVIRDVDGSPLTSEQGRRIVADRYTVPADIRAARRTTGARTGRRHQESHSAPPIGPSTTKATSLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVA2</accession>
    <name>A0A231GVA2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40567">
        <property type="protein sequence ID" value="OXR40567"/>
        <property type="gene ID" value="B7C42_07376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="58" mass="6364" checksum="3F455E1E89E65745" modified="2017-10-25" version="1">MGKVKAKEVAHLTPKKKCCRKKKRCLKCPVVVSKMKKCQAAGVKGKDLKKALKLARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVL5</accession>
    <name>A0A231GVL5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782256.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40654">
        <property type="protein sequence ID" value="OXR40654"/>
        <property type="gene ID" value="B7C42_07211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="170" mass="18712" checksum="518F33DF18E697B2" modified="2017-10-25" version="1">MSGNITGRSEPTVSITDIEYSLDEMATLFCSHAAQFACEEHAGDLGLVDTNDAQHHWRDGLIRGMWYQLAQAFICSPLPWESTGARLLEIDATVPEQYRMLHIDPGAGHEYGFTADNLARYRASLAFTTASQIVGHTAEQALVDWQFSKQLLGLAPDEPYPDDPRSLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVP6</accession>
    <name>A0A231GVP6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Tyrosine recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">xerD_2</name>
        <name evidence="11" type="synonym">xerD</name>
        <name evidence="15" type="ORF">B7C42_07258</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40700">
        <property type="protein sequence ID" value="OXR40700"/>
        <property type="gene ID" value="B7C42_07258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01807">
        <property type="entry name" value="Recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="13">
        <location>
            <begin position="112"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR40700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="32989" checksum="E4D397E50AE8ACD0" modified="2017-10-25" version="1">MVERQIQAYLDHLTVERGAASNTLSAYRRDLQRYREFLRQRDIGDLDRVTENQIADFVVSLRAGGEGYPALAASSAARALVAVRGLHRFAAAEGLTTGDVAHGVKPPAPARRLPKALPYEDISRLLEAAGGGDDAGSGGGPRGLRDRAMLELLYSTGARISEVVGLDVDDIDTTGRAVVLHGKGGKQRMVPIGRPALAAVDAYLVRGRPALGARGKGTPALFLNARGGRLSRQSAWQVLQDAADRAGIGAAVSPHTLRHSFATHLLDGGADVRVVQELLGHASVTTTQIYTLVTVNTLHEVWATAHPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVZ4</accession>
    <name>A0A231GVZ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40742">
        <property type="protein sequence ID" value="OXR40742"/>
        <property type="gene ID" value="B7C42_07166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="24801" checksum="10AAA14AB40B2EA1" modified="2017-10-25" version="1">MVGLPALIERNPTYTTRSIRTSTDHSEYTLKTFRTSAAIALLTVAATTTTCGIAGADPTPSAIVAPAGHQGFEQGVGYDISSSGTSVTVALTGGSFRIGEDAVTVADSNGATVASLPLRLSAGDRGLVLTPRTDSAATTLVADISAQDVGYWRKTSPRQRSIEAGMGIGALVGGLTGTFIGIVVGIATEGLLLPITLPVGLLGGVLGGMAVGGAAGAAIPNSDVPDQWEYQQECHGSGEYQYCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW95</accession>
    <name>A0A231GW95_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ESX-1 secretion system protein EccD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eccD1</name>
        <name evidence="3" type="ORF">B7C42_07132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40848">
        <property type="protein sequence ID" value="OXR40848"/>
        <property type="gene ID" value="B7C42_07132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="508" mass="52839" checksum="275B32B5B59CC0E2" modified="2017-10-25" version="1">MTAAYATAPAAAAPTAEVARARIAIMVATYQVDVVVPTKFTIETFIDDLLGVLSRAIDDENMDFTPPSGQWSLARPGELPIPRWRSLADHDVVDGTVLMLTAVESAEMFTPVVEDITDALAMINEREFAEFDRGTIAIVGVSALGVGAVAAAGMLAWSWTETGSLWWCGLPALLLGVAYWVAALVVRGRRLAPGISLGLALSAVPLLSAGGAMLVPPAYGEPGAFAAANIAAGAVVAAVSAATMMRVTRFGIATLMSVTVLGVVITAAAIPATYLDIALRQVTAGLVFAGLIVLTAAPRLAVVIARIRPPDLPDPGSEVAPSTLTDIFDAEAAREADPELEEQDERDRRRAHSGIEARARLAVTSLRGLMAAVAVLLSVSTVVTAAASPGGIREIVLAVAVAGILVLRARWFPDRVQALALVSAAAITLTGLGFVLVGAYHTPGARLVVVLVAVAAAVAACVAALRLPGTRLSPVTRRVIDLIEYALIVIVPVIAFWIMGIYTAMREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWC7</accession>
    <name>A0A231GWC7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cystathionine beta-synthase</fullName>
            <ecNumber evidence="5">4.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbs_2</name>
        <name evidence="5" type="ORF">B7C42_07013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40878">
        <property type="protein sequence ID" value="OXR40878"/>
        <property type="gene ID" value="B7C42_07013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="4">
        <location>
            <begin position="15"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="38659" checksum="F613E2F3D8726C05" modified="2017-10-25" version="1">MTVADRQLGVFDSVADAIGNTPLIRLNRVTEGITATVYLKLEYLNPFGSVKDRAARAMIDAAEAAGELRPGGTVVESTSGNTGIALAAIAASRGYRTIVVVPDKSSAEKLALLRAYGVEVHVTAGGLPRQHPDFLKNVALRLAADIPGAWYSGQYDNPANPAAHRETTGPEVWSQTGGRITHFVTGIGTGGTITGTGEYLKSVSRGQVRVIGADPESSIYSGGDGHAWYVESIGHYLHPRTDTDEWPQSYHPEVVDRIERIPDAEAFEVLRRLAGEEGLLVGGSTGTAVAAALRVARAGSRRRGGGHRAGLGAQLPVQILRPTVAGTLGFRCRAHRTWPSCRRPGCGRGGRGRSGGRSVGCDRGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWL6</accession>
    <name>A0A231GWL6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042806.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41014">
        <property type="protein sequence ID" value="OXR41014"/>
        <property type="gene ID" value="B7C42_06980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="111"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17091" checksum="4099A491D1E378D3" modified="2017-10-25" version="1">MRTAVDEFSTIGIRAGSSGDAPVHTVRPVRRHRRADLRRPRGLQRPHVVAGYDRVPVAAPARGPHPLQRVEQARIGLATLAATALLTAAAVCGLVGVAQLRDAGGPASTQTVQVQPGESLSDLAQRVAPKDAVRDTVARIVELNGLRGTEVAAGRTLVVPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWT0</accession>
    <name>A0A231GWT0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-methylmercaptopropionyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="10">1.3.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dmdC_5</name>
        <name evidence="10" type="ORF">B7C42_06844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.-" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41074">
        <property type="protein sequence ID" value="OXR41074"/>
        <property type="gene ID" value="B7C42_06844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="288"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="474"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="608" mass="65731" checksum="7ED1158135AEABF5" modified="2017-10-25" version="1">MGHYKSNVRDLEFNLFEVYGLGEVLDSGAFGDLDGDTARTMVAEAARLAEGPVAESYAETDRHPPVFDSDSHSVRIPEPFKRSVRAWQDAQWWRVAKSEAIGGVPAPSMLGWAINELVLGAQPAAYMYLSGPMMANVLAGIGTEQQRRWAARAVEREWGATMVLTEPDAGSDVGAGRTTATEQHDGSWHLEGVKRFITSADSDDLFDNIMHLVLARPAGAGPGTKGLSLFIVPKFHFDHDTCEPGERNGVFVTNVEHKMGLKASATCELTFGGHGIPAVGYLVGGVHNGIAQMFEVIEEARMMVGTKAIATLSTGYLNALDYAKTRVQGSDPARAADKAAPKITIIGHPDVRRSLMMQKAYAEGLRSIYLYTAGHQDPVVARHISGADDDLAARINDLLLPIVKGVGSERAYQYLTESLQTFGGSGYLQDYPIEQYIRDAKIDSVYEGTTAIQAQDFFFRKIARDNGIALAHVLGQVRATAESDADRGRLKNEKVLLSRALENVQEIIGRLTTHLLEAAVEPREVYKIGLNAVRLLLAVGDLLVAWRLIVAAETALTAIEAGQNTAFYAGKVAVASFFANSALPHITAELAVVSGTDTTVMDLEEAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXE8</accession>
    <name>A0A231GXE8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3-dihydroxyphenylpropionate/2, 3-dihydroxicinnamic acid 1,2-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhpB_3</name>
        <name evidence="2" type="ORF">B7C42_06650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.16" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41252">
        <property type="protein sequence ID" value="OXR41252"/>
        <property type="gene ID" value="B7C42_06650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047070">
        <property type="term" value="F:3-carboxyethylcatechol 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="233"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="354" mass="39548" checksum="D5F4C272A1460095" modified="2017-10-25" version="1">MAEVIGVGLTHYPLLAGTDEHMADLLKSALKDPDIPEEVKDRASWSELARREWGEDGGTAAAAGHRRHLLADLERCRAAIDDFDPDVLIVWGDDQYENFREEVIPSFCVLAYPDTVVHPFGVLDMLRVPNVWGLPSDTSFVMRGAPELAKAAASAVLSSGVDVAYSYQPRTGIHFPHAFGNTQLFLDYDKVGAQFPYPIVPMAVNCYGEHVIARKGGIARFADINLGENLDPPGPTPARCFEFGRAVGRFARQSDQRIALVASSSWSHAFLHDKGWHLRPDTESDQELYRGMRAGDYDLWNARTSRQIIESGQHEMLNWYCLLGAVRELDMRLDWSDLVVTEIFNSNKAFAVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXL1</accession>
    <name>A0A231GXL1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase FadD15</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41373">
        <property type="protein sequence ID" value="OXR41373"/>
        <property type="gene ID" value="B7C42_06516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="596" mass="63877" checksum="7F2FE9129C267E94" modified="2017-10-25" version="1">MREFEVPATYTIPEDANMSDGAFRHAERTPGLVVFNRPDGTGGWTDVTAAEFAKHVTAVAKGLIASGIELGDRVAILASTRYEWVVLDFAIWAAGGCTVAIFDSSSAEQARWILSDSGTKLIVVENARHRATIAEIEDGLPELGEPLVIDDGAIDTLVARGKDLGDEAVHERRKQVKAASPASLIYTSGTTGRPKGVMLSHANLYAESAADRAAMPQFLKPGHRSLLFLPLAHVFARAVALAAFDAGVTVAHTADWSTLVEQFGEYKPDFILSVPRVFEKVFNGAKQKAHDGGKGKIFDLAADTAVEYSQALDNGGPGLVLKVKHTVFDKLVYGKLREAMGGRCKSAVSGGGPLGARLSHFFRGIGVTIYEGYGLTESTAAVSVNTPEHLKVGSVGRPLGGHAAKVAEDGELLLRGPVVFAGYWNNPDATEDAFDDGWFKTGDLGAIDEQGFITITGRKKEIIVTAGGKNVSPAMLEDSLRSHPLISQVMVVGDGKPFVGALITLDPEALPGWKTRNNVPEDTPIEKLIELPELTAEIDKAVKDTNKLVSHAEAIKKTRILPVDWTEESGELTPKMSLKRNVVMKNYATEVEAIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXN1</accession>
    <name>A0A231GXN1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma-E factor RseA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rseA</name>
        <name evidence="1" type="ORF">B7C42_06475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780499.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41332">
        <property type="protein sequence ID" value="OXR41332"/>
        <property type="gene ID" value="B7C42_06475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="14423" checksum="EE0694B315BD9667" modified="2017-10-25" version="1">MTGEGRFAPTEHLANEAVVAYVDGELRMNAYLRAAEHLSRCPECAAEVEAQQQARVALRRAAQMQISAPTDLQDTLSRIPLADLTSSSTEEMTRGASFLGLRADSFRFASSSNREIGFESRRWTGWWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXS2</accession>
    <name>A0A231GXS2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="2">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acsA_7</name>
        <name evidence="2" type="ORF">B7C42_06719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41321">
        <property type="protein sequence ID" value="OXR41321"/>
        <property type="gene ID" value="B7C42_06719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding_C" evidence="1">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13336" checksum="A1554BDB5BB37E2F" modified="2017-10-25" version="1">MNVSGHRISTAEVESALVGHHSVAEAAVVGASDTTTGQGIVAFVILTGGSNNSGQQLVDELKAEVSREISPIARPREIHIVPELPKTRSGKIMRRLLRDVAEGRELGDTSTLVDPNVFEAIRASNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXV8</accession>
    <name>A0A231GXV8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780460.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41361">
        <property type="protein sequence ID" value="OXR41361"/>
        <property type="gene ID" value="B7C42_06504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032407">
        <property type="entry name" value="MHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038378">
        <property type="entry name" value="MHB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16525">
        <property type="entry name" value="MHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04529">
        <property type="entry name" value="MTB_hemophore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011317301" description="MHB domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="MHB" evidence="2">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="11575" checksum="A9A8632721B101D2" modified="2017-10-25" version="1">MKRTVAALLAGTAGIAALAVAVPGVASADAPQCSPQARAQVQAQTAPQVAAFLASHPDLAAELAKVKGLPKEQRKAELQAYRQGHQQELKDFRGVRQPVIDYHKSCHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXX1</accession>
    <name>A0A231GXX1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Limonene 1,2-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">limB_4</name>
        <name evidence="2" type="ORF">B7C42_06366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.107" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41474">
        <property type="protein sequence ID" value="OXR41474"/>
        <property type="gene ID" value="B7C42_06366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106319">
        <property type="term" value="F:(R)-limonene 1,2-monooxygenase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106320">
        <property type="term" value="F:(R)-limonene 1,2-monooxygenase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052601">
        <property type="term" value="F:(S)-limonene 1,2-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="37537" checksum="41672647FF289E1B" modified="2017-10-25" version="1">MSSPRIASLAFLTPGNYLDDDPYTGLEDTLQLFEYGERLGFDGAWIRQRHLEHGVGSAAVFLAAAAQRTSRVELGAAVIPIGYESPFRLAEDLSLADVLSKGRLQPGFSAGTPPHADLIGDLVFDGDWRSFDLSYGRVARLIDNLRGHYLGDADTVIHSPGNTQRPRLQPHSPGLADRVWYGGGSTRSVRWAAENGLNLLSGNIVFGDRSDDFVTAQLGLIDDYRERIDPSRPARVAIGRVIVPFDSADRATRERYRAYAAGRHERTLGPQGERRVLFAPDVVGTAEQILEQLRADPVLAQTGELRLELPYEFHRADYEQILHDTVELIAPELGWKPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXY6</accession>
    <name>A0A231GXY6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gph_3</name>
        <name evidence="1" type="ORF">B7C42_06376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41484">
        <property type="protein sequence ID" value="OXR41484"/>
        <property type="gene ID" value="B7C42_06376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="23995" checksum="9B3570E648D46024" modified="2017-10-25" version="1">MPEPAAVLFDIDGTLVDSNYLHAVTWHRAFREVDAEVPTWRIHRSIGMDGDELLRTLAPDLDSETADTASDLHSRYYLERAGELTLLPGAREILRHLHEAGLRVVLATSAPPDELARLRDLLDSESVLYAVTGAEDVETAKPDPTIVQVALDRAGVTAQRAVFVGDTVWDMRACTKLGVAAIGVLSGGISRGELAADGAAFVCDDVAHLLRDLHRSPLASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYC4</accession>
    <name>A0A231GYC4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41633">
        <property type="protein sequence ID" value="OXR41633"/>
        <property type="gene ID" value="B7C42_06274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="18236" checksum="26F113972080896F" modified="2017-10-25" version="1">MSTPSTPPSTGTAAGESAGRGRLRMQSAVDAAMRALLRSPLHRLLSAKLMIVTVVGRKTGRVYANPVGYAESDGALLVGTAAGWRRNLRPGEPVRITWRGRERLADWDVISGEDEIAEPYRIILTQNPTHGRFAGIGLDADGNVNREQLRAALARGTVVVRLRPRSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYF8</accession>
    <name>A0A231GYF8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor CarH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carH_2</name>
        <name evidence="2" type="ORF">B7C42_06304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41663">
        <property type="protein sequence ID" value="OXR41663"/>
        <property type="gene ID" value="B7C42_06304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="100"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="37782" checksum="DCC2BD0DEEA14158" modified="2017-10-25" version="1">MSEPYRRNSRDASAYRDELWTAVTGRDERAAIGIVLAALDSGLEPEAVLLDVIAAVQRRVGAEWAANTLSVADEHTATAINDRAVTALALHATGARSGSAGRVTVACVDGEWHALPARLVAEVLRLRGWHVDFLGAQVPTRHLIAHLHNTGPDAVLLSSSLPTRLPSAHGTITACQAAGVPVLVGGAAFGPGGRHAKSLGADAWAPDAATAAELLARGLRREQRPHRTLPHLTDQEFTMIARSTPQLLTTTMAELEHRFPGMREYSEYQLERTAEDIAQILEFLATALYLDDDELFITFVTWTAGVLSARAVPAQSLLPVLDLLGGQLQDFPRARRILTAATDALTDTARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYL9</accession>
    <name>A0A231GYL9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41707">
        <property type="protein sequence ID" value="OXR41707"/>
        <property type="gene ID" value="B7C42_06049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12223" checksum="8B6A05AD3410193A" modified="2017-10-25" version="1">MPEAAESSPKSNHGCNAPARLFPIVRERLVTKALYWLNPCCNRLSVPRIARFTRYAAGAYSVSAAVFTRLAPIRSGTMYGGWNPDMAAAAAEAPNMTRLAPRIILVGSMVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYM0</accession>
    <name>A0A231GYM0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobIJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobIJ</name>
        <name evidence="10" type="ORF">B7C42_06262</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41621">
        <property type="protein sequence ID" value="OXR41621"/>
        <property type="gene ID" value="B7C42_06262"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="9">
        <location>
            <begin position="294"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="550" mass="58077" checksum="806D772F164AFA37" modified="2017-10-25" version="1">MSAQGAEEAARVTERPSSFLDGHSMSAPGKLWGVGLGPGDPELVTVKAARIIESADVIAFHSARHGRSISRSIAAPYMRPGQLEEHLVYPVTTETTDHPGGYQGAIDEFYERAAELLAGHLAAGRTVALLAAGDPLFYSSYMHMHRRLADRFPAEIIPGITSVSAASAALGTPLVEGEQVLTVLPGTMPPDQLAERLTDADAAAIMKLGRTYPGVRQALSKAGRLDDAYYVERASTGRQRILRAADVSDAEVPYFAITVVPGPTPTTEIPFTTAEPAAAQDVSSTSPAPEVGEVVVVGLGPGSAQWTTPEVTRALAAATDIVGYTTYVNRVPVRPGQRRHLSDNRVESERAAMALDLAKSGARVVVVSSGDPGVFAMAAAVVEESADPQWRDVPVRVLPGVTAASAVAARIGAPLGHDFAMISLSDRLKPWETVAQRISAVAAADMAIAIYNPASTQRRWQVGTLRELVLEHRGPDTPVVLGRDVGGPSESVRVTTLADLNPDEVDMRTLLIIGASTTATVETPHGTRVFTSRRYGQAAKDDAATVAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYS5</accession>
    <name>A0A231GYS5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpsN</name>
        <name evidence="5" type="ORF">B7C42_06090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780833.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41748">
        <property type="protein sequence ID" value="OXR41748"/>
        <property type="gene ID" value="B7C42_06090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="11611" checksum="EBE4A316D8364560" modified="2017-10-25" version="1">MAKKSKIARNEQRRAVVARYAERRAELKELIRDPATADDRRAAAQLALQRLPRDASPVRLRNRDATDGRPRGHLRKFGLSRVRVRELAHRGELPGVHKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ68</accession>
    <name>A0A231GZ68_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41897">
        <property type="protein sequence ID" value="OXR41897"/>
        <property type="gene ID" value="B7C42_05881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="37101" checksum="CC7C0AA79BC1E2F0" modified="2017-10-25" version="1">MAGYWGAQPPRRMEQTIAEAEALGVDSFWTAESYGSDALTPLAWWGAKTNRIALGTSVCQISARTPTALAMAAQTIDHLSGGRLILGIGASGPQVVEGWYGRPYPRPLERTREYVAIMRAVWERTEPVTFAGKHYQLPYPGGTGLGKPLKSIVHPLRRDIPVYLGAEGPKNVALAAEIADGWTPLWFSPKSDEFYRTALSEGFARDGARRTAEDFEIANVCWLSEDDDVDRAAARLKPVVALYAGGMGAQGANFHNDVFARMGWGEVCAEIQRLYLGGRADLATQAVPTAMVEDVALVGPVDKICEDIVNRWKPTCLTTVILGGWPKPESRERILEAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZE1</accession>
    <name>A0A231GZE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicarbonate transport ATP-binding protein CmpC</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmpC</name>
        <name evidence="5" type="ORF">B7C42_05952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778990.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41968">
        <property type="protein sequence ID" value="OXR41968"/>
        <property type="gene ID" value="B7C42_05952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="27228" checksum="E8F87D0BA15C68CA" modified="2017-10-25" version="1">MAIAAHDLVVRFPNAERPTLRGIDLTVPDGSFTVLVGASGSGKSTLLHCLAGLLPPTSGTVTDAGERVTGPDPRRGVAFQRDVLFPWMSVAANIEFALRAHGVATRERRDRIAELLDLVGLPADVGGLRPSHLSGGMRQRVGIARMLAGEPGIMLMDEPFAALDALTRLNMQDLLIDVWTRLQRTVVFVTHDVDEAIRLADTIGVLRDGRIVDLISNPLPRPRPADTLADQPGYSGLRRSLHHELGIVRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZK6</accession>
    <name>A0A231GZK6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-3-phosphoglycerate synthase</fullName>
            <ecNumber evidence="2">2.4.1.266</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gpgS_1</name>
        <name evidence="2" type="ORF">B7C42_06022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.266" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42038">
        <property type="protein sequence ID" value="OXR42038"/>
        <property type="gene ID" value="B7C42_06022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="325" mass="34141" checksum="1F93BB1E85276FA9" modified="2017-10-25" version="1">MTYAAPAESTCPADDVGTTDLIRAKGDRTVSVVIPALNERDTIAGVIDSIRDLVGGLVDELVVVDSGSTDDTIARARAAGASAVFTREQALPGVPVRAGKGEVLWRSLAVTTGDIVVFIDSDLHDPDPGFVPALVAPLLRDPRIQLVKGFYRRPLGDDPHGDTDGGGRVTQLVARPLLTALAPELADVRQPLGGEYAATRALLTEIPFAPGYGVEIGILLDTLHRYGRAAIGEVDLGVRIHRNRPTHELAVMSRQIIATLLARLDIADSGVGLTQFRPGATGWRRVTTPVSAAERPALASLITTNPAAGSAAGRVRGPANARSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZT4</accession>
    <name>A0A231GZT4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor FabR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fabR_2</name>
        <name evidence="5" type="ORF">B7C42_05722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42123">
        <property type="protein sequence ID" value="OXR42123"/>
        <property type="gene ID" value="B7C42_05722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="23685" checksum="7D4F6095088ABDB5" modified="2017-10-25" version="1">MRGAERCEDDRVSTAPKLWRGQTLQDRSGERRELLLDCAFDLLGTAGAGAVTMRAVTRQANLSPRYFYESFAGREALILAVYDRAEAALRERLSVIAAGTDPHAAIRSALQTCADFFDEDPRRARVLLREPLADDDLRAHITRRTPAVIRALAPLLGDSAGDLFTSSDATLATTGTALAGALTSVYLEWTDGHLTIERDRLVDTCTGIVAALLGLALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZZ8</accession>
    <name>A0A231GZZ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase-2 operon protein HybG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hybG_2</name>
        <name evidence="3" type="ORF">B7C42_05777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42178">
        <property type="protein sequence ID" value="OXR42178"/>
        <property type="gene ID" value="B7C42_05777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11831" checksum="FF19128E13BF3766" modified="2017-10-25" version="1">MCLAVPGKVLDLYERDGTLMSVVDFGGVHKDVCLQYIPDAAIGDYVVVHVGFAIQRLDEESALATLAEFEHLGVLNEEFGDGFAIAARQSGLPDPTSGAPSEPAPDDEVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0D4</accession>
    <name>A0A231H0D4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine gamma-synthase</fullName>
            <ecNumber evidence="5">2.5.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metB</name>
        <name evidence="5" type="ORF">B7C42_05534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42335">
        <property type="protein sequence ID" value="OXR42335"/>
        <property type="gene ID" value="B7C42_05534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102028">
        <property type="term" value="F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="382" mass="40104" checksum="45F50507DB232EEE" modified="2017-10-25" version="1">MTDDQLGFSTRAVHAGFDPDPQTGAVNVPIYASSTFAQDGVGGLRGGYEYARTGNPTRAALEANLAALESGSYGRAFSSGMAATDCALRATLRPGDHLVIPDDAYGGTFRLIDKVFSQWGIEYSVAPVSDPDAVRDALRPNTKLVWIETPTNPLLNVGDIAALADVAHGGGAKLVVDNTFASPYLQQPLLLGADIVLHSTTKYLGGHSDVVGGALVTDDAELDAAFAFLQNGAGAVPGPTDAFLTLRGIKTLALRMDRHCDNAETLAAYLADHPAISHVIYPGLPEHPGNLVAQKQMRRFGGMISVRLHGGKQAAHDFCARTKIFTLAESLGGVESLIEHPGAMTHASTEGSELEVPADLVRLSVGIEDIGDLLADVERALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0U9</accession>
    <name>A0A231H0U9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 3</fullName>
            <shortName evidence="5">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">prfC</name>
        <name evidence="7" type="ORF">B7C42_05612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42411">
        <property type="protein sequence ID" value="OXR42411"/>
        <property type="gene ID" value="B7C42_05612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="539" mass="58616" checksum="8C51CB841CB59F0D" modified="2017-10-25" version="1">MNSPSASTTTSGRVAQEAERRRTFAVISHPDAGKSTLTEALALHAKMISEAGAIHGKSGRKSTVSDWMEMEKARGISVSSTALQFEYGECVINLVDTPGHSDFSEDTYRVLTAVDAAVMLIDAAKGLEPQTLKLFQVCRHRGIPVITVINKWDRPGRAPLELLDEISERIGLTPTPLFLPVGIAGDFRGLLRRGPEGAATEYIHFTRTAGGATIAPEESYTPDQAAAREGEPWETAAEESELLSATGQDHDQELFLAGQTSPVIYASAMLNFGVRQLLDTLVALAPPPGPRADVDGAPREPADPFSAVVFKVQAGMDAAHRDRLAFMRIVSGEFERGMVVTHAQTGRPFATKYALTVFGRERATVDTAYPGDVVGLVNATALAPGHTLFVDKKVEFPPIPSFAPEHFATLRARSAGKYKQFRKAIDQLDSEGVVQVLRNDLRGDASPVLAAVGPMQFEVVTARMQAEFNVETQLDFLPYQLARRTDAASSPELDRQRGVEVFTRSDGVILALFSDKWRLQYIEKEMPELTLEPLVATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Y7</accession>
    <name>A0A231H0Y7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional activator mta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mta</name>
        <name evidence="2" type="ORF">B7C42_05306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42530">
        <property type="protein sequence ID" value="OXR42530"/>
        <property type="gene ID" value="B7C42_05306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="36298" checksum="1464B05EE3E479FD" modified="2017-10-25" version="1">MLIGEVARYSGVSARMLRHYDSLGLVRPTGRTNGGYREYSVQDIRRIFHVEGLRSLGLSLTQIGRALDDPGFTPSALVGDLVRATEERLSRDRELLERLRAVEAAEPSGWQDALRIVELLRGLGSSNAARRQQAVLAPSEEMPAELLAEAVLAESDPYVAGALRWALARAGADGVLNVASGLDSADVEVRRRAASALAEIAGQESSAVLLDALTDPDATVRRISALALGARGDTRAVPELVATVIEGPNDVEAAELLGSLARDTQWADRILGALAGELAAHPPGSPVRLRLTQALAELPGSLALNTLRPLVHDVDRAVALLAAALVRTLEHGPPADPESTESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H109</accession>
    <name>A0A231H109_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] synthase 1</fullName>
            <ecNumber evidence="5">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kasA_4</name>
        <name evidence="5" type="ORF">B7C42_05319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42543">
        <property type="protein sequence ID" value="OXR42543"/>
        <property type="gene ID" value="B7C42_05319"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="8"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="41152" checksum="00AFF847BFEF64AC" modified="2017-10-25" version="1">MAATTCLGPDLDSTWSALLAGKSGIGPLTDEFVTRYDLPVRIGGRLTEHPGAHLNRIEQRRHSYVQQLALVLGRHVWSQAGTPEIDAERLAVAIGTGLGGGDAFLTAVDAMREGGYRKVPPLTVPMVMPNGPAARVGLEFGAKAGVYAPTSACSSGAEAIAHAWRLIRTGEADVVIAGGVEGYIEAIPIASFAMMRAMSTRNDEPGLASRPFDRDRDGFVFGEAGALLVLESEEFARARGAAVHGRILGAGITSDGYRITGTDPDGAGAARAMRKAIAAADLTAADIDHIDAHATSTPIGDASEANAIAAVAKHASVYAPKSALGHSIGAVGALEAILTLCTLRDQTVPPTLNFDNPDPGVDLDIVHGIARPQRISQALSNSFGFGGHNVTLAFGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1J5</accession>
    <name>A0A231H1J5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42725">
        <property type="protein sequence ID" value="OXR42725"/>
        <property type="gene ID" value="B7C42_05062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="331" mass="34098" checksum="54495321366B42BF" modified="2017-10-25" version="1">MDKRRSLLVGGVAIAVVAAVAIASLAYRGLRSDDSLRIALHTEQIGDGVLAGTPVRVDGVQVGEVAAIVPADGGTQRISLRLDRSQLHGIDDSLRVDYAPVNLFGISEIELRPGAGGAPLRGGSTIELTGQHADAVYDATMGGLLRGLSQTGNALLTPQMATVIAQVSNDVRGFTPLAQALISVAQTITDNQKMPSSELVGRLGPAFDGGGRFAGATIQVLDLLRNIPRLQDHRGSYDAGTSALTGSVLPALAGLGARAGSELSGTTDTLAPMLAVPARLVPHPQQSGADLAELVRRLRAGLHDTPDGPVLDTEIDVRGVPVLAPLLGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H216</accession>
    <name>A0A231H216_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42890">
        <property type="protein sequence ID" value="OXR42890"/>
        <property type="gene ID" value="B7C42_05229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8128" checksum="97F5CC362A5F9185" modified="2017-10-25" version="1">MEGIKLDFAGTPWETLPLLLPIPRAAILLGISRSAAYRLAESHELPVKRMGGRVYVVTARLPALLEDESSEQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2G7</accession>
    <name>A0A231H2G7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiseptic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">qacA_8</name>
        <name evidence="7" type="ORF">B7C42_04929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43043">
        <property type="protein sequence ID" value="OXR43043"/>
        <property type="gene ID" value="B7C42_04929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="508" mass="51875" checksum="BA7F2C16DAFEE668" modified="2017-10-25" version="1">MVGIETSAAGYTAPSATPRRAWLGLAVLILPVLLVSMDMSVLYLAMPTLTEHLDPSAEQQLWILDIYGFMIAGLLITMGNLGDRIGRRNILLAGATVFGIASLLAAFAPSAGVLIAARALMGVGGATLLPSSLALISSLFPEARARGTAIGIWTAFFAGGSAVGPVIGGLLLHKFWWGSIFLINTPVLLVLLALGPLLLPEHRSAGRGPLDPVSVIMSIGGILPLVYAVKRAAAEGVDVVSVVLGLAGVAVLVAFVRRQRTLAEPLLDLSLFRRGLFRVAIGSSTVGMMSLAGMSYLTSMYLQSVAGRDVLGAALLGIPAAIAVFVCSMGGARVARRLGTRGSFVLALSAAAVGNLLLLGIGVDGGIGWYIAGSTIAGLGYGIVFTLVSEVAVSSVPAERAGSAVGISETSFELGNALGLSLLGSLAALVFRSGGDFADTLGETLVRHRGDAAVIHAAQSSFVTGMHTALVVGAALLIMMAVTAAATSGRRRRRAIAVDTASAAVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2K2</accession>
    <name>A0A231H2K2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator WhiB7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">whiB7_1</name>
        <name evidence="2" type="ORF">B7C42_04967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500951.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43081">
        <property type="protein sequence ID" value="OXR43081"/>
        <property type="gene ID" value="B7C42_04967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="9448" checksum="E42C8EDA6726F678" modified="2017-10-25" version="1">MTTTTPALTLVDLLPVSDTQSWEQAACKGDPNHDAWFPYPSQDFDYARGICAGCPIRRQCAEFAATTGQSGVWGGHEFDRGKLIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2N0</accession>
    <name>A0A231H2N0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_22</name>
        <name evidence="9" type="ORF">B7C42_04996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43110">
        <property type="protein sequence ID" value="OXR43110"/>
        <property type="gene ID" value="B7C42_04996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="41982" checksum="578C34098FB3324D" modified="2017-10-25" version="1">MPVHRSPWMDEDLDALTDLARRFFEKECAPNEDRWGRQHHVDREIWNRAGELGLLCISIPEEYGGGGGTFAHEAVIAIEQTRAMAPSLGNPVHSTIVAHYINAYGTEEQKQAWLPKMASGEIVAAIAMTEPGTGSDLQGIRTRAVADGDHYVIDGAKTFISNGLLADLVIVAAKTSEGKGAESVSLIAVETDREGFRRGRNLEKVGQHGQDTCELFFDSVRVPKTNLLGATEGTGFIQLMQQLPQERLILAVAAAAAIEKTVEMTVAYTKERQAFGKPIFNFQNTQFTLAECDTIASVAWAFLDDCVAKHLRAELDIPTAAKAKWWLTEQQCRVADECLQLFGGYGYMAEYPISRVFTDARIQKIYGGTNEIMKLIIGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2T8</accession>
    <name>A0A231H2T8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43154">
        <property type="protein sequence ID" value="OXR43154"/>
        <property type="gene ID" value="B7C42_04576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="93" mass="10247" checksum="6BFB0AAF00177B57" modified="2017-10-25" version="1">MGSNATGSGTAFCLRLLPESVEALRESGGTSLTELSGERVQAAMNEYAVTLPWNADFFGALERMVERWVRYFFDHPVERALTAASTLENGWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H307</accession>
    <name>A0A231H307_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(3S)-malyl-CoA thioesterase</fullName>
            <ecNumber evidence="6">3.1.2.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcl2</name>
        <name evidence="6" type="ORF">B7C42_04675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.30" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43253">
        <property type="protein sequence ID" value="OXR43253"/>
        <property type="gene ID" value="B7C42_04675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="11"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="30082" checksum="EBCCCDE532B83C8D" modified="2017-10-25" version="1">MPSEQNPVRRRAVLVVPGAAEHRIVKALHAGADEVVIDLEDAVAVDAKESARGLVANLLRGIERDPARSVAVRVNGFTTAWAADDLRALAATSTVDSIVIPKVEDSATLERAHALLDGHPASLQALIETPRGVLAADDICRTSAPLAAVVIGYADLGAALGRGADLPPGRWAAIQDRILLAARANDVAAIDGPHLAVADDDDFRSRVRWAHEAGFDGKWVLHPAQIAAATAQFTPDQDAVEHARAVLAALDEATRGGAGVARLGDRMLDEAVAIAARRVLTRIGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H346</accession>
    <name>A0A231H346_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase FadD13</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43291">
        <property type="protein sequence ID" value="OXR43291"/>
        <property type="gene ID" value="B7C42_04713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="406"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="498" mass="52984" checksum="2CF6A6E118B507F4" modified="2017-10-25" version="1">MNLTMLLDMAIDGFSDRVVIGRREGGITAARLGEMSAAGAAAIRESGADSVVYLAVNGPAFPVAMFAAARAGVPLVPVNYRLGAEQLESLLANHPRAIGIADEAQVPILERAGLTVLTPAQWLARASEPVAAVPDAEETEAPAVVIYTSGTTSAPKGVLLRHENLTSYVFGSVEFASAEPTDAALISVPPYHIAAVANAITSLYSGRRTLVLERFTPAQWLQLAREEDISNALVVPTMLARIVDADGDKALPSLRSLAYGGAPMPTSVIEKALRMWPEVGFVNAYGLTETSSTVAVLGPEDHRAALASSEPAVRARLGSVGRVVPGVDLEIRDANDAAVGPGVTGTICVRGEQVSAEYAGIGRAVDDRGFFNTRDQGFVDEDGYLYIGGRMDDTIIRGAENIAPAEIEDVILRHPAVLDTAVVGVPDEEWGQRIEAAVVVRPGMVLDPEELRAHVRNVLRGSKTPERIVYWDELPRTETGKLVRRHVLDRIVADDVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H386</accession>
    <name>A0A231H386_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009503.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43331">
        <property type="protein sequence ID" value="OXR43331"/>
        <property type="gene ID" value="B7C42_04754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="34939" checksum="14AF347F90F863D6" modified="2017-10-25" version="1">MLTTRFTEEFGVEHPIVQGGMMWVGRAELAAAVSEAGGLGIITGLTQPTPEDLAKEIARTREMTDKPFGVNLTLTLSINPPPYEEYRHAIIDSGVKIVETAGSNPQVHVEHFKQHGIKVIHKCTSVRHALKAQSLGVDALSIDGFECAGHPGEDDVPGLVLIPAAADKLSVPILASGGFADGRGLAAALALGADGINMGTRFMCTVESPIHQRVKEQIVAATELDTQLIFRQLRNTMRAAKNSVSEEVVEILGKGGRFKDVQELVAGTRGRKVYENGDPEAGIWTVGMVQGLINDIPTAGELVTRIAAEAESVLRRNTALISDPVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H392</accession>
    <name>A0A231H392_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kshA_5</name>
        <name evidence="9" type="ORF">B7C42_04688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43266">
        <property type="protein sequence ID" value="OXR43266"/>
        <property type="gene ID" value="B7C42_04688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="37602" checksum="FBD138DBD05103E2" modified="2017-10-25" version="1">MTELPSARPTGWFQVAWSADLGDGEVKALHYFGTELVAFRGNDCHVRVLDAHCRHLGAHLGHGGCVVGDDIQCPFHGWRWNGEGRNTHIPYHDKPNRVRRVRAWPVTERNESIYIWHDSEGRPPSWEVPDAFPALGDHIARVDYFPLTEQARSRHAGVHVHPQVIAENAVDPWHFRFVHHTPHAPVVLRETVQGARWQSKVGFGRRWSDGVDRAEDTSNTIEILWSGIGLSFNGEVTADGIRVIAICPTPVDDTTTDIFATYWIDKDNGRYDERLAQAKLALPDDIAIWEHQKYMDPPGLAPSEAAGFRRLRTWATRFYPETAPADPNSAAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3A7</accession>
    <name>A0A231H3A7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43351">
        <property type="protein sequence ID" value="OXR43351"/>
        <property type="gene ID" value="B7C42_04774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="11723" checksum="BE5BC722B62053CD" modified="2017-10-25" version="1">MAAPHEPTYPVSVGAGALHKSEAWYLRQLKAGALPGHRAGRTWFLTAADIAAAIEHTATAAAYLAVGAAAPAPPAATPRPPVTVCVTGGVARREDRQASACSLPGHVHALTRANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3T7</accession>
    <name>A0A231H3T7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43505">
        <property type="protein sequence ID" value="OXR43505"/>
        <property type="gene ID" value="B7C42_04372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="11348" checksum="5DFC859E0E7925A2" modified="2017-10-25" version="1">MPHRSYRRVSPQVRKAAVEQVVALTDKLRSESEACRVVAEQIGVHTNSVRNWVRAAEGPSLERMDAVALRRKVALLQQQLAAAAEMNRTLVETLNETRRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3U3</accession>
    <name>A0A231H3U3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779183.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43559">
        <property type="protein sequence ID" value="OXR43559"/>
        <property type="gene ID" value="B7C42_04427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="128" mass="12690" checksum="F8143EA32B3EDD99" modified="2017-10-25" version="1">MGAIGFGAGVRPPGAGRATTRRIRGFGAAEAAPPGGGDIRRMRNVGGYSTVGFRAIPPIGRKPAPDEADAEADALTDAVLARADEVLAQADELLAYGGEDAYAESGTAGAQTPTAHAGDELAGAGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3W6</accession>
    <name>A0A231H3W6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="15">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">carB</name>
        <name evidence="19" type="ORF">B7C42_04426</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="15"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779184.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43558">
        <property type="protein sequence ID" value="OXR43558"/>
        <property type="gene ID" value="B7C42_04426"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="685"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="958"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="15">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="15">
        <location>
            <begin position="958"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="835"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXR43558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1108" mass="118883" checksum="81BC965AAA01EE83" modified="2017-10-25" version="1">MPRRTDLNHILVIGSGPIVIGQACEFDYSGTQACRVLRSEGLRVSLVNSNPATIMTDPEFADSTYVEPITAEFVEKVIAKERPDAILATLGGQTALNTAVALHENGVLEKYNVELIGADFEAIQRGEDRQKFKDIVAKVGGESARSKVCYTMDEVRETVAELGFPVVVRPSFTMGGLGSGMAYDDEDLDRIAGGGLAASPTANVLIEESILGWKEYELELMRDGRDNVVIVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQKMRDLGIAILREVGVDTGGCNIQFAVDPRDGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEIVNDITKETPACFEPTLDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFSEALGKVLRSLETKAAGFWTQPDGRWTDVAEILDDLRVPTEGRLYQVERALRLGASIEDVAQASGIDPWFVAEIAGLVDLRAEIAQAPVLDEPLLRYAKHNGLSDRQIAVLRPELAGENGVRELRHRLGIRPVYKTVDTCAAEFEAKTPYHYSSYELDPAAESEVAPQPERDKVIILGSGPNRIGQGIEFDYSCVHAAQTLSQAGYETVMVNCNPETVSTDYDTADRLYFEPLTFEDVLEVYHSESESGRVAGVIVQLGGQTPLGLAQRLTDAGVPVVGTSAAAIDLAEDRGEFGDVLVAAGLPAPKYGTATTFEQAKQIAAQIGYPVLVRPSYVLGGRGMEIVYDENSLEGYISRATELSPEHPVLVDRFLEDAIEIDVDALCDGEEVYLGGVMEHIEEAGIHSGDSACALPPITLGRSDIEAVRRSTAALAKGIGVKGLLNVQYALKDDVLYVLEANPRASRTVPFVSKATGVQLAKAAARVMLGTTIAELRKEGILPAEGDGGHAPMDAPVAVKEAVLPFHRFRRPDGTGIDSLLSPEMKSTGEVMGIDADFGTAFAKSQSAAYGSLPVAGTVFVSIANRDKRAMVFPVKRLHDLGFRILATEGTAEMLRRNGIPCERVRKQSDPVPAPGNGEPIEPSIVDQIKDGEIDIVFNTPYGNSGPRVDGYEIRTAAVGANIPCITTVQGAAAAVQGIEATINGGIGVRSLQELHAVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Z9</accession>
    <name>A0A231H3Z9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell cycle protein GpsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpsB</name>
        <name evidence="1" type="ORF">B7C42_04349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43482">
        <property type="protein sequence ID" value="OXR43482"/>
        <property type="gene ID" value="B7C42_04349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="176" mass="18959" checksum="034AAA1D751E591F" modified="2017-10-25" version="1">MRVTPEYVRGIRFGRAPIGHRGYDPAEVDAFCAALADAFAGRAALSAAAIRGHEFGLAAPGRRDYDRDEVDAFLDRACVELEFARYGPARPQVAWPPSPEYVSRLRFSAPPLGRSGYVADEVDAFRERVAALLAQTITGWDAAAIRPEFGTAATGVRAYHSGEVDAFVDAVTALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H433</accession>
    <name>A0A231H433_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tkt</name>
        <name evidence="11" type="ORF">B7C42_04492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43624">
        <property type="protein sequence ID" value="OXR43624"/>
        <property type="gene ID" value="B7C42_04492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="714" mass="76873" checksum="1BCA6D62E946D2A1" modified="2017-10-25" version="1">MSVTDDIRALTQPAHPADWTELDTRAVDTVRVLAADAVQAAGNGHPGTAMSLAPLAYTLYQRVLRYDPSDPDWTGRDRFILSCGHSSLTQYIQLYLSGLGLELDDLKHLRKWGSLTPGHPEFRHTRGVEITTGPLGQGLASAVGMAMAARRERGLYDPSAATGASPFDHFVYVIASDGDIEEGVTSEASSLAGTQQLGNLIVFYDDNRISIEDDTSIALTEDTAERYRAYGWHVQVVEGGENVTGILAAIEAAKAVTDKPSFILLRTIIGYPAPNKMNTGAAHGAALGADEVAATKEILGFDPGQSFVVDDEVIAHTRGNAADRAKAARAVWQEQFDAWAQNNPENKALFDRLRERRLPKGWTEGLPSFEPDAKGMATRKASGKVLAALAPVLPELWGGSADLAESNNTTMPGVPSFGPASISTGMWKAEPYGRTLHFGVREHAMGSILNGIALHGPTRPYGGTFLVFSDYMRPAVRLAALMRVPAIYVWTHDSIGLGEDGPTHQPIEHLAALRAIPGLNVVRPGDANETVYAWRTILELESAEQHSHFVPADHPHTDGPSALALTRQDVPTLEGTSYEGVSRGGYILAESSTGTPQVILIATGSELQLAVAARTTLEEQGIGTRVVSMPCVEWFDAQEQSYRDEVLPPQITARVTVEAGIAMPWHRFTGSDGENVSIEHFGASADFKTLFREFGITAEAVVDAAKRSLDKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4C6</accession>
    <name>A0A231H4C6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vegetative protein 296</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">B7C42_04510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502483.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43642">
        <property type="protein sequence ID" value="OXR43642"/>
        <property type="gene ID" value="B7C42_04510"/>
    </dbReference>
    <dbReference type="GeneID" id="66722943"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="27918" checksum="F585F55E18B261E8" modified="2017-10-25" version="1">MTTLEIKDLHAEVANPDENGEPIKILKGVNLTVKSGETHAIMGPNGSGKSTLSYAIAGHPKYTVTQGSITLDGEDVLAMSVDERARAGLFLAMQYPVEVPGVSMSNFLRTAATAVRGEAPKLRHWVKEVKESMGELEIDAAFADRSVNEGFSGGEKKRHEILQLGLLKPKIAILDETDSGLDVDALRIVSEGVNRYKERENGGVLLITHYTRILRYIQPQFVHVFVGGRIVAEGGSELADELDANGYVRFTQTATAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4D1</accession>
    <name>A0A231H4D1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiseptic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">qacA_6</name>
        <name evidence="7" type="ORF">B7C42_03923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43688">
        <property type="protein sequence ID" value="OXR43688"/>
        <property type="gene ID" value="B7C42_03923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="546" mass="55639" checksum="F88F0407A50DB295" modified="2017-10-25" version="1">MTTRAGAASGSTLVLAVLGSGQFLMTLDSSVMNVSMATVAHDVGTTITGIQTAITLYTLVMASLMVTGGKVGTILGRRRAFGVGLVVYGAGSLVTGLAPNLGVLLLGWSLLEGIGAALIMPAIVSLVAANFGRERRAAAYGLVAAAGAMAVAVGPLLGGAVTTFASWRYVFFGEVVVVVAILLVLRRVADVPAQRVHLDLLGSVLSVAGLGAVVFGVLRSSEWGWVRPRPGGTEIAGLSPVIWLILAGLLVLYAFLRWQHRLVRSGREPLVDPRLFASRRLGGGLAMFFAQFAIQAGVFFSVPLFLSVVLELSALETGVRILPLSVALVAAAAGIPKFVPRADPRRVVRIGLGSMIIGILLLAGGMDPGANAGVVAVPMLFMGLGLGALASQLGAITVSAVPDSQSAEVGGLQNTATNLGASLGTALIGSILIATLTSSVIGGIENNPAVPPSVAQRATTELADGVPFVSNTQLRQSLDAAGVDTSTADAVVAVNSDARLLALQVAFAVTAMLAVIALFFTGRLPRRAVGSDPDAGTVADERTGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4E3</accession>
    <name>A0A231H4E3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43690">
        <property type="protein sequence ID" value="OXR43690"/>
        <property type="gene ID" value="B7C42_03925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="7705" checksum="17A20ADE5241C6CE" modified="2017-10-25" version="1">MRTPTAVGPADTVDRLIAEFGARLPRRAVEIAVASALRDLRGSPVPALPELVERLARQRLTDSATSPTTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4R7</accession>
    <name>A0A231H4R7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43889">
        <property type="protein sequence ID" value="OXR43889"/>
        <property type="gene ID" value="B7C42_04128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="20144" checksum="C04FC987FDCB28B6" modified="2017-10-25" version="1">MRITGSRWRSFEYTPVDAGPCAVELPTAAVGVPRRFFDCLLVRIVVEPGDCPISGDAVRTVRRLCADSDASFVVLAGSPFCVARDSRLTLGSDQADVLSHLADTLDVLAEFTDRLEEHGERAHAIPFGWNVACRMEMPAQPWTSTVTLRAPAPPSRFDGFAPPPRARPHCPHALVSAHSRTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4X8</accession>
    <name>A0A231H4X8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43905">
        <property type="protein sequence ID" value="OXR43905"/>
        <property type="gene ID" value="B7C42_04144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="302"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="40454" checksum="6836C09495F0E1F0" modified="2017-10-25" version="1">MSGAALTIPDVEKWDPDKLGTAATAVGKLSGDLDQAVVAAVNSTQKLGQDQKWGGGAAQAADGRMQVEKSRASTVSQAVLGLQTALNQQVENLKNAKLAVLQMRDQATFVPAPSVMPAFEVNPDGTVNPQKRLDWLDQHRDKLNDIEYTAKTTEIKTDAAAHEWAIVNALKNAQTVADSAITALNGAKAPVDAAFAGLGDPVTGAGAAPPAAPAPTAPAAAAPPAAPAATPVASHSGSPASSSLMGNSHHGGGTSSYSGGSYGGSSNGPTSGPPPTAHPSGDVQQWIAQAKQVLIEMGYPPESIDENAIALIIEHESGGDPNAINNWDSNAAAGHPSKGLMQCIDSTFNAHAAPGHTDIWNPVDNIVAATRYSIDRYGSLDNVPGVSAVSGGGGYVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4X9</accession>
    <name>A0A231H4X9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781090.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43887">
        <property type="protein sequence ID" value="OXR43887"/>
        <property type="gene ID" value="B7C42_04126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18228" checksum="AB996E0F6AAD53A1" modified="2017-10-25" version="1">MTDTVTHDPTMAAIGAAVERGRDGETDSARTRLVELWEEIGPAGDPLHRCTLAHHLADLHTDPARALVWDVRALDAADALTEARVQSHHASLHIAGFYPSLHLNIADNYRLLGSFAAAAEHIAVARRHIGALADDGYGRLIRRAIEEVAAAIEHRSTRRRDSAPGTSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H539</accession>
    <name>A0A231H539_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781145.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43836">
        <property type="protein sequence ID" value="OXR43836"/>
        <property type="gene ID" value="B7C42_04071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="129"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="23881" checksum="A0F99F46489FA310" modified="2017-10-25" version="1">MSERAEPAIDTSAVDADRYEKHGGFPKVEEAELGANYAPFLEAMRTLQDLTVSVDCPDEVFGQALAQANALAELLEPYRAPELQGPSGRVPSLPGRGSLLLPPWVMTEAGPTGVRMRGEFRRYHLGGNNAVHGGVLPLLFDDLFGSLVHYAGRPISRTAFLHVNYRKVTPLETPLTVEGTVDRVDGRKTFVSARLRDESETLLADCEGLMVQLLPWQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H547</accession>
    <name>A0A231H547_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR43991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783861.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43991">
        <property type="protein sequence ID" value="OXR43991"/>
        <property type="gene ID" value="B7C42_03547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10644" checksum="6814F75C3C2454F0" modified="2017-10-25" version="1">MKVFLDDSEDINPDSPTGAFTTATMTTKVNKIASHYGVPPQAVRDAIHKIKAQGAWRGNGGSRNPDIVVDLDDGEVYVKMPDGSPSEDSIGNILDELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H557</accession>
    <name>A0A231H557_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein Stp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">stp_8</name>
        <name evidence="7" type="ORF">B7C42_04161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43922">
        <property type="protein sequence ID" value="OXR43922"/>
        <property type="gene ID" value="B7C42_04161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="477" mass="48389" checksum="13F1EF2960EE44F1" modified="2017-10-25" version="1">MYRKYSPPLALAAITMAQLMIALDMAVVNVALPAVRRELGFAPIDLSWVVHVYALTFGGFLLLGGRAGDLFGRRRLFTLGLCGFALASLAGGLAQHPWQLIAARAVQGVAAAAVAPATLAMLTVLFPHGPARVRAFGLWSAANGAGGALGVLLGGVLTEYAGWRWVMLVNLPIAALVLGLGLFGIPADRRDGMRPPLDIAGALTATGGAGLLVLAVVRTDRYGWFSTATVGTVVAALLLLAAFVWFERRASVSLIRLSLLRNRWVAGADLFVALAAAGQFAAFYFVSLYMQQSLGMSAAATGLAFVPFSAGVVAGTVVATRLGHRRSPRTLLISGSLLAAAGLGWFALLDADGDFATAVLGPSLVTSIGFGLCLAPLAAAATTGVAPAEAGMASGLMNSARQIGGAIGLAALASVAAQRTGSAQTPEAVTAGYATGLAIGAVLLLGAGVVAAVVMPRRTAARSTSTPLPAPAPVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H574</accession>
    <name>A0A231H574_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44021">
        <property type="protein sequence ID" value="OXR44021"/>
        <property type="gene ID" value="B7C42_03577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11172" checksum="CD375B0E101D8DCE" modified="2017-10-25" version="1">MFSVYGRMTALPGRRDELIAVLLAGFRAGGDDSGLLHYSINTAFDDPDTIWLTQLWRDKEAHDVTTRSEPVAAVSRQVPPLLAQQPEGGYGHAVHVGGRIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5A1</accession>
    <name>A0A231H5A1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PglZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR43988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783853.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43988">
        <property type="protein sequence ID" value="OXR43988"/>
        <property type="gene ID" value="B7C42_03544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PglZ" evidence="1">
        <location>
            <begin position="511"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="939" mass="102248" checksum="7DFD2614B37096EF" modified="2017-10-25" version="1">MTATVAGAMRLSRTTVAQYLAANHKLTEILTAPQGNITILLRGEPVWDGDPVLALSDGRAVRVEAAPSPLAVHEQILAHARDINPEPRVLVVITDVEEHDLDPAILARVHRAHIYVVDQWDIVRETFGTKEIDPMLRRITWVCEALLDASGARRWPAALAGDVLSRTPTLAALAARRLDLGDVGDRIDARSLLIWSQRPGHPQLLLDLRGPERDGLIEFLSETDQSGPTGRILTTLAVNGHGDEAVAYGLLCAALWRHAAPNNPVYQARGRVERWLGEGFPIKGEALDSVLSSFGAVCEDYISDLLTRARTETDPGDEADEHARQARKITDTVLSRADAIARQFGALEAASSSPILAVGLEARITAAGNALGRGRLESIDRAVTDLRNHKLAPDHHVRIQRIRMAQRLTRWLATAPDPTIDTVAAAIDRQMRDTAWADRALDALEAGGDDDPAVRIAYQDIATKVRAVRREFDREFATVLAQWTASGSAPGSMLTVETFLHRVVRPLAATRRVMLIVIDGMSSAIATELAGELRKSFAEYDPLPGDKHVRRRSMVAALPSLTAVSRTSLFAGTLMKGDQKDEARLFPAHRFWGAKQAEVFHKHDLRSAAGDRFGSDLLNALANPDKHIAVVLNTIDDRLAKELKLDDAAWQTREVGDLRALVASAAARDMAVLITSDHGHVIDRHGRACDGAGVASARHRVPTSAHDRLDDSEIALRGPRVVWPEPGASIVALWDADSRYTAQKAGYHGGASLAEMTIPVLAFLPFESDPGDWQELGSGQQPKWWIDDAEETLDVPEQKAVTERAKRASTKARELASDQITLDLVVPEADRPAQQALGSADALIKDLLNSDTFAAQLETLARKPAAGKLEKAIRALLDGPQTTTALAQRIGELPSRARSFAAVLTQLLNVDGQQVLETHSDGRTLRLHVGLLHEQFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5F3</accession>
    <name>A0A231H5F3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murD_2</name>
        <name evidence="9" type="synonym">murD</name>
        <name evidence="11" type="ORF">B7C42_03687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44129">
        <property type="protein sequence ID" value="OXR44129"/>
        <property type="gene ID" value="B7C42_03687"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="133"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="135"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR44129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="501" mass="52003" checksum="8FE7A74AFD66192E" modified="2017-10-25" version="1">MVEHTPRALRSPGPMLEFLRGRDVLVAGWGVSGRSLIEPLRDIGARPVVTDAGEKAMAEAAELGLDTATGAALLEPGALERFALVITSPGWRPGSPVLVSAVTEGIPVWGDVEFAWWVDQARLYGPVRKWLVITGTNGKTTTTQMTHAILRAAGLPSVACGNIGLPILDALRRTPGPQILAVELSSFQLHWAPSVRPEAGVVLNVAEDHLDWHGGLDAYAAAKARALTGRVGVVGLDDAVAAALARKSKARRTVGFRIGVPADGELGVVDGKLLDRAFTKAAILAEVGDISPPGPAGVADALAAAALTRAIDVAPQFVKEGLAEHKVGPHRAAFVRELAGVGFVDDSKATNPHAARSSILAHPQVVWIAGGQLKGAHIDDLVEEVAERLVAAVVFGQDAPIIAAAMARHAPDVPVVELGSGDDAQMSGEPSTASLVAEIDGADAVMARAVRIAAGYAGRGDTVLLAPAAASLDMFADYTHRGRSFVAAVQALDERDIGSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5R4</accession>
    <name>A0A231H5R4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44229">
        <property type="protein sequence ID" value="OXR44229"/>
        <property type="gene ID" value="B7C42_03789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="DUF4188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="227" mass="25986" checksum="702EA067AA6468CA" modified="2017-10-25" version="1">MRVNRLTADLSGYPDLVVIYLGMRVRTPRGVLRLLGLGPKLYRSHHDRPDGLLRHEDIIWSLFPPHWGARQYWRDLDSLERWTRSQPHRDWWQRFLRDSGGTGFWHEAYFLRGGIDTMYDDMTTPTGLGAFAPTRTMRGPLFSARGRARDNAARAGADNAHLGAEPTVAPVVEEASYYSKRFRRRRFRGGPAGVAPRPRASGQLRAAGQRQFGKRSNATRYRQLNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5U3</accession>
    <name>A0A231H5U3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44177">
        <property type="protein sequence ID" value="OXR44177"/>
        <property type="gene ID" value="B7C42_03737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="85"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="379" mass="41814" checksum="AE22BCDF2A8DBE6D" modified="2017-10-25" version="1">MRDRHPSTVADYDDARRRARLTETRVGHRWRSLGRTRRVLLRAALVPIVVLVVFAQYWHYDVSPEQARLARTDPAVLPISGPAAASERDTAVFDLVGLGSLDASDTARALPSLRQLGSVWAVRYDNTGIDTKVISDLIIRVTEAARIHKVVLVGHSMGGVIALEIAKHIHTHSTRTLSGVILDCTPVDLAAVRPESRDQGEDLLRWFGWFPGTRESRGLRLLAETYSRRDQFIDYGSDPPGIRMASLGRTVADVLRQKIFNTDAASNGLIEDQFKAIVASGAIDDLHALAKPASGKARPAVVFIRPHDPYRDSVVDDEYTHRTLIDTVGGVDGTLLVVLTRSTGHADPRQHPREYNTVIAQQIVPFIGLVHSEQTMGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H652</accession>
    <name>A0A231H652_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitric oxide dioxygenase</fullName>
            <ecNumber evidence="5">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hmp_4</name>
        <name evidence="15" type="ORF">B7C42_03876</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the globin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44315">
        <property type="protein sequence ID" value="OXR44315"/>
        <property type="gene ID" value="B7C42_03876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="13">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="166"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR44315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="411" mass="44018" checksum="3F3CCFDD53DA4BEE" modified="2017-10-25" version="1">MTTASTSALDTIAELEPHHAEIVRATLPVIGARIDDITAEFYRRLFAAHPDLLRNMFNRGNQAQGEQQRALAASIATFATHLVDPNLPHPRQLLARIGHKHASLGVVPDQYPVVHEHLFAAIVHVLGEAVTAEVAAAWDRVYWLMADTLMGFENELYSGAGVEPGAVFREVRVVQRIEDPAGTVTFVVESADAAAPLPAFVPGQYVSVGADLPDGARQLRQYSLVNAPGAGRLAFAVRRVTAVGDRPEGEVSSWLHTDVEVGDRLQITLPFGDLTIDTAARTPLVLISAGIGVTPMVGILEYLAATGSRRRVLALHADRAESTHPLRGTQADLVAGLPEAELHVWYEQPGAGAHAGLLSLTGIELPAGAEIYLCGGTGFLQAARAQLKAAGVADERVHFELFAPNDWLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6M9</accession>
    <name>A0A231H6M9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dapE_2</name>
        <name evidence="2" type="ORF">B7C42_03364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44574">
        <property type="protein sequence ID" value="OXR44574"/>
        <property type="gene ID" value="B7C42_03364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="206"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="456" mass="47965" checksum="8A4D9CF4A816D194" modified="2017-10-25" version="1">MTDESRTAALRAQVRALMPQAKADLAQLVSYRSVADARQFPPEECHRAARWVADAFAGLGPADVGLHETPDGSEAVVARYPAPPGAPTVLLYSHYDVQPPVDEAAWETPVWELTERDGRWYGRGAADCKGNIVVHLTALRALRNTLGDKGYPVGITVVCEGSEEQGTGGLEEFVPGHADLLRADALLIGDCGNFAAGVPTFTQTLRGNVNVLVTVETLSGPLHSGMYGGAAPDAVAALIRVLATLRDEHGNTTVDGLAADQVWAGAQYPVEQFRVDAGILEGVQVLGSGSISDMLWARPALTVLGIDVPPVVGSAAAVQPSARARLNLRIPPGVDPAPALKALTAHLESHTPWGARVRIETEGTGAPFRSGTGGPARLAMEDAFAAAYGRTATTQGQGGSIPLCNVFAETYPDAEIMLLGVEEPKCLIHAPNESVDPSEIEHVALAEALFLSSYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6W8</accession>
    <name>A0A231H6W8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome bd-I ubiquinol oxidase subunit 1</fullName>
            <ecNumber evidence="13">1.10.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cydA</name>
        <name evidence="13" type="ORF">B7C42_03389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.14" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776030.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44599">
        <property type="protein sequence ID" value="OXR44599"/>
        <property type="gene ID" value="B7C42_03389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR44599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="53148" checksum="1C91F47FAD0F66D1" modified="2017-10-25" version="1">MDVVDVSRWQFGITTVYHFIFVPLTIGLAPLVAGMQTAWVITGKDHWYRLTKFFGKLFMINFALGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLAMEGLAAFFLESTFLGLWIFGWSRLPKLVHLATIWLVAIGVNASAYFIIAANSFMQHPVGARYNPESGRAELESIGALLTNNTALAAFPHVVAGAFLTAGTFVAGIGGWWMVRNARSGHPELLEEARGMWRPAARAGMWVIVIAGIALVFTGDIQGKLMFKQQPMKMASAESLCHTETDPSFSILTVGTHNNCDSITRVLEVPGVLPYLAEGRFSGVTLQGVKDLQASYNEKFGPGDYRPNLFVTYWTFRAMIGWAAGSAVIALLGFWMTRRGRIPDQPWFKWVSLICIPTPFLANSAGWVFTEMGRQPWVVAPNPTGNPAIRMTVQQAVSGHTAGTVLTSLIVFTLLYGALAVVWFFLMRRYVIEGPEQPPAETETPAVEKLSFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H744</accession>
    <name>A0A231H744_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44744">
        <property type="protein sequence ID" value="OXR44744"/>
        <property type="gene ID" value="B7C42_03539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1113" mass="122152" checksum="C861B590A064E8CF" modified="2017-10-25" version="1">MQNQFPLPRGENIDVADDRGRIGRDSAHDAQEAIGEVLHRRLVEQIGRIAERCRDTLWHTVFVDALGHGELQVEFGRIDRQIDARHREAGQFQFGAGQVLEGQHDLEQRMPAGRTRRVENLHQPLERHIGVAERGDVGAAHVREHLFETACRIDLGPQHQGVDEHADQLVERLVAAARDRGADRDVARAGQAGQQDRQRGVHDHEERGLMFVGEAVQCRVHRRVDLEVVGAAAVGRDRRARTVGREVQLLGQRGEFAAPEGDLRGEHRLGIVLAAQRFPLPQRVIGVLDRERRPFGVAAARPVEVGGHQIAGERAHRETVAGDVVDHAHQHVLGLAQPQHPQAHRRRGRHVEAAGDGLGDQGGHLVLGRLDQRDPRYRTGIRERQHLLVALAVEFGIDGAQHLVAFHQIPHRGPQRVHVEASAQPHRDRNVVDGPGGIEAVEEPHPLLCVGQRDAFGPGHRPQPLPGSGSGVAFHLFGERGHGRGLEQQLHRYAGAQRRADPGRRLGGQQRVAAEFEEVVVGADPAGVVPVAGDEQGCEDLGDDLLHRGGGSAEFAGREGRFRQPGAVEFAHRGQRNLVQRHDRRRNHVRGQRFRQEIVQARDIERGPGTRQHIRHQRRRARGQRAADGGGEVDIRMGGQRVVDLAELDAETADLDLEVGAAQIFDGAVGFVAAHQVAGAIQPSAGPAGLRAERTGDEPLGGQPRPIQIALRQRRAGQIELPDHACRHGTKPRIEDVGPDAGDRGTDRDRLVGSHFCGGGGEDRRLGRAVTVVEAAAVARPAPDQLGTELVTRDHHDLEVGQIGRVHRLQGARRDQHVRNAFAPQQIRQLETTEHVRRGDDQGRPRREGQQQFKHRDVEVGRADVEYPGALGHAVVLALGRDQSAETRVRHHDALGAAGGTGRVDHVGRMRLGERAHAVGVGDRMRRMRGDPLGDNRIVEFEPVHATAERTAIRAGGQAEDGAGIGDDMRDAVGRIGRIDRHVGGTRLGDRPHREHRFDRARDADGHHVARADTARDEFPGQARGRLVQLSIGQLPRIGRLTGRIEPDRYRVRGGFHRSGQQLTEKRAARPAATTSTSGTAGSIHSSVFTSRVQQVRTVQHPLARSEQSYKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7H2</accession>
    <name>A0A231H7H2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytochrome P450 123</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44973">
        <property type="protein sequence ID" value="OXR44973"/>
        <property type="gene ID" value="B7C42_02930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="401" mass="44791" checksum="A21397DB4DD4B678" modified="2017-10-25" version="1">MTVASAQPVVFDPYDYRFHEDPYPVYRRLRTEAPLYYNPDLDFWALSRHADVTAAFRDAARLSSANGVSLDPAAWGPHAHKTMSFLAMDDPRHLRMRQLVNKGFTPRRIAGMGDRIRELTLQHLEPALERGSFDWIEDFAGKLPMDVISDMMGVPEPDRAEIRRMADLVVHREEGVLDVPEAAIEASLNLVVYYSDMVAQRRRSRTEDLTSALLDAEIDGDKLTDDEIIGFMFLMVVAGNETTTKLLGNALYWAGRNPEQFAKVVADGDLVPDWVEETLRYDNSSQMVARSSVVDVPFEHGVIPAGSKVVLLIGSANRDDAVFTDGDRYDIERTDKSALASFGGGVHFCLGAHLARLETVVALREFASRVREYSVDESAVERVHSTNVRGFAKLPVTVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7M3</accession>
    <name>A0A231H7M3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44881">
        <property type="protein sequence ID" value="OXR44881"/>
        <property type="gene ID" value="B7C42_02836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="37539" checksum="AF7D1DAAB4FA9596" modified="2017-10-25" version="1">MRVIQWTTGKVGKLSLRGILDDPRLELAGVYAYSDDKVGVDAGRLCGRPDTGVLATADIDALLALDADTVIYTPFMADLDHATRLLASGLDVISTNLFLNVGGIQGETERKLAAACERGNSSLHITGINPGWVNAVTTALTAVCRDIRSISIFESADVSVYESAETWQALGISRPEATPELIEIAKLWMSTFRDSVRRMGVALGYEFDDMDFSIEYATAAETVDLGWIRIEKDTIAAVRGGWAGTVGEKSLVRSNVAWYLTEKLNESWEFDDDHYHIVIEGEPEVRTRIRFVPPDSWGNHEWDTMTAMPAVNAVFDVARAPAGISTLKEVGLPCAPADLWLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Z2</accession>
    <name>A0A231H8Z2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45424">
        <property type="protein sequence ID" value="OXR45424"/>
        <property type="gene ID" value="B7C42_02549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="334"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="46269" checksum="8306AD6673186604" modified="2017-10-25" version="1">MDRQVEVVAGNHVVVRVAGAVVVVAHRGRGRVHPDAPAMRAAEALAQLVSEASEHAPQGPGRIIAREATRWLIQEAEQVDGSPVDLGILSRSDTGGVAIFLHGAVTVVLAGARGVEYYRGVDAAFTVDRFTEPPARAAALFIDDERGRIPELPERGIGSLVEGVAAAAGAVVWFDGERTRARDRAARPAPGAHHRAEDAPTSQLDAQRPEPHVPPPPTRPDRSPEVDARQGTSRPEPAEDPRLAETRLRGTNPAPGPDPELERRMEATARATSLTVRVMGFKCARAHPSDPRSAFCTVCGMPVDQTQQPAEVVRPPLGMLVLDDGMTYLLAADAVIGRDPENSEAAQRGLVPVKIEDSSGGMSRAHAEIRLMNWDITVVDRGSTNGTRARPAGYRDWIRLPPNQPMVLAQGSEIQLGNRVLRLEPAAPPPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9P1</accession>
    <name>A0A231H9P1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rplV</name>
        <name evidence="12" type="ORF">B7C42_02675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025347178.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45550">
        <property type="protein sequence ID" value="OXR45550"/>
        <property type="gene ID" value="B7C42_02675"/>
    </dbReference>
    <dbReference type="GeneID" id="66718916"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR45550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="14665" checksum="D8B1371567AB4204" modified="2017-10-25" version="1">MSEQDTTLQNPTARATAKHVRVTPMKARRVVDLVRGKRVEDALNILRFAPQAASEPVAKVVASAAANAENNFGLNPDTLVISTAYVDEGATMKRFQPRAQGRAFRIRKRTSHITIEVESVASAAPARSRRKGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC3</accession>
    <name>A0A231HAC3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase PknD</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pknD_2</name>
        <name evidence="2" type="ORF">B7C42_02083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45791">
        <property type="protein sequence ID" value="OXR45791"/>
        <property type="gene ID" value="B7C42_02083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="34"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="531" mass="54636" checksum="48377EE345FD53CA" modified="2017-10-25" version="1">MTTPARYLTSTAASVADGWTLDRITAPSRLFGANGIRTGADGRIYVAQVAGSQISALDPNSGDLETISAMGSDIVAPDDIAFAPDGELYITEYYDGRVSIRDGKGETRVLRDDLPGANGITFHQGRLFVDECRPGGRLMELDPAGGAPRILLDGLPMPNALEVGPDGKLYYPLLGSNEIWRIDPDGGEPERVAADLGGPDAVKFDAAGRIVSTQVATGEVVRIDPRNGERTVLATVGPGLDNLTFVGERLFVSSFTGKITEILAGGATRTALADGLTWPLDLTVGPDGTLYIADGTFLLAVPPGGELRTAGMLFSPGYPGYIRGLTATGDGDLIVTGNGSVSRYRPAASESEVIVDGLDQLYGVAVAPDGTVAVADRGTGMVHAVRGGRTELLASGLHDPMGVAFTAGGTCLVAEAGAGRVVAIDGSTADTVTDGLGCPHGLAIHDGLVYVVDVEAKELIGLDPKTEARQVIARNLPVGAPPGVTPKPLKGLLPFSGPQGPFSGIAAGPDGTLYLSGDAEGSVLAIRRDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAE3</accession>
    <name>A0A231HAE3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msuD_2</name>
        <name evidence="2" type="ORF">B7C42_02110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45818">
        <property type="protein sequence ID" value="OXR45818"/>
        <property type="gene ID" value="B7C42_02110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="32457" checksum="AA91610029565D5B" modified="2017-10-25" version="1">MSLRFIFHYPETGGPDGDVLDAGPLREVAITAERCGFDGLSLSEHPIPGARWLNNGGHQTLDSLVALGYVAAATERLRLLTYLAVAPYRNPLLLAKAAATVDKLSGGRLVLGLGAGYQKSEFHALGVDFEERNALFDEALEVLPLHWRGEPFSYRGRHFDARNVIARPRPVQDPIPIWIGGNSAASRRRAANRAQGWMPMSGGAALSTTARTPALGSHTELAAQIAEVRTRAESAGRSGDLDVLYSYHDSDLLDPAAADRHLESFAGLEKAGVTWIVVSSRTADHAATTDFLDAFGATYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAG5</accession>
    <name>A0A231HAG5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_3</name>
        <name evidence="4" type="ORF">B7C42_02247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45954">
        <property type="protein sequence ID" value="OXR45954"/>
        <property type="gene ID" value="B7C42_02247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="447" mass="49238" checksum="C3803A93278288FE" modified="2017-10-25" version="1">MSPSPKTFHLNAFLMGVGHHEAAWRHPRTEERRVLDVKHFQELGRIAERGKLDSVFFADGLAVGPRIQRNTLAVFEPVTLLSAIAAATEHIGLIATASTTYNEPFNLARKFASLDHISGGRAGWNIVTSGSVDEAYNFGYDAIPEHARRYERATEFVDVALQLWDSWESSAVVLDPEAGVFADPDKVHTIDYDSDRFRVRGPLNSPRGPQGRPLLVQAGSSESGKEFAARYAEAVFTAQRTLEEGQRFYRDLKSRLPKYGRGADELKVLPGLVPYIADTPAEALALEQEFTDLISPDYALRQLSTQLGIDLTDHPLDAPLPPLPVESEIEGNKSRFTLVKELATQEQLTVRQLIGKLGGGRGHRSFAGTPEQIADELQTWFEADAADGFNIMPPYLPGGLTDFVDRVVPILQERGLFRTEYTADTLRGHYGLAPVESRFAAGAAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ3</accession>
    <name>A0A231HAQ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45950">
        <property type="protein sequence ID" value="OXR45950"/>
        <property type="gene ID" value="B7C42_02243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012985929" evidence="1">
        <location>
            <begin position="22"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="431" mass="46113" checksum="CE5586D2713CE8D5" modified="2017-10-25" version="1">MATRRAVLRAAALAPVLTACAPGVLFGHPASVRIAVPWSGSELVAFRRVLDDAGLGATVAVLPLGDDIDTALQARGRSAPDLVMLPEVGRIGELAGGVLRALPPTLWHDAAGPRYPDRWRSLLWKDGALYGIPFKAADKSLVWYDRYAFGGDRSRDDPRDWTVSQWPQRIAEATARRPLALGGADGWVLADLFGNILYGESAWDYEDLAAAGEPDRPREWDRDAVRATLYRLGTMWAPRGTFPGGIAATLTRQFPESVREVFERRTAAMVVAPDFAEPIVRSCLRRAGRPADAVGVMPFPAVAPGGRRPAIGGGDVIVATAAGAHDAVPVLGALTAPGAVSAWIGDYGGFLAPSPRTVPDHAPMLDPVAGQLHSWSAFDFADLIGAAGRRDGLWRVLTDLLITVGDGHAERLDAAVDHAVRALDEFERRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ6</accession>
    <name>A0A231HAQ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 monooxygenase PikC</fullName>
            <ecNumber evidence="4">1.14.13.185</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pikC_1</name>
        <name evidence="4" type="ORF">B7C42_02194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.185" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45902">
        <property type="protein sequence ID" value="OXR45902"/>
        <property type="gene ID" value="B7C42_02194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="422" mass="45682" checksum="588C7C6609923A5D" modified="2017-10-25" version="1">MTTPHSLESPSNRCPVAHSSPIAADGPRVPLYTEEFAADPRGGYERMRAHHRSFAPVELAPGVPATLVIGYQAALRILNDPEHFPADPRAWQRTVPADSPILPMLGWRPNALRSTGAEHARFRAANVAAIDGVDLHTLHTVVERVAIPLINSFSVDGRADLLTQYIRPLAFTSLNTMLGIEPDIAERVAAGLAPIFDVTGDAAAGNRMLAAALQEHTDRKRAHPGDDITSRLIAHESALDDEEVINQLVSLYGAGIEPQLHLVANALLLMMTDERFSGNLLGGTLTTRDALDWVLFNNPPLANYCASYPRQPMLIDDVWLPANQPVLIGIAACNNDPQVREGDRNGNRSHLSLGAGPHACPARRIAYLIAQDTVDQLLDALPDIELAVPVAELRWRPGPFNHALAALPVTFPPSPPLQSPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB01</accession>
    <name>A0A231HB01_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_00994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030516569.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46031">
        <property type="protein sequence ID" value="OXR46031"/>
        <property type="gene ID" value="B7C42_00994"/>
    </dbReference>
    <dbReference type="GeneID" id="66717546"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="90" mass="9339" checksum="D79F3EDD4AE82A8F" modified="2017-10-25" version="1">MLGLGIIGWIIIGGLAGWIASKIMGTDAQQGILLNIVVGVIGGLIGGFILRLFGVDVHSGGFFFSFLTCLGGAVILLWLVRLATGRKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB07</accession>
    <name>A0A231HB07_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative zinc metalloprotease Rip2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rip2</name>
        <name evidence="15" type="ORF">B7C42_01079</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043363.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46114">
        <property type="protein sequence ID" value="OXR46114"/>
        <property type="gene ID" value="B7C42_01079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR46114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="28399" checksum="5ED390654A76A023" modified="2017-10-25" version="1">MRNHGGAREYRRGISPSPIFLLIVVITALGGALAWDADPLSTRAKAGVFVLVVAGWILSVCLHEFGHAYTAYRAGDREVQMRGYLTLNPVKYSHPLLSIALPIFFIALGGFALPGGAVYLNTQNFSARTQRAISAAGPAVNALCAVVLLVIVRFAGSTHDHAAFWFGLSFLAFLQITATILNLLPIPGTDGYAIVEPSLSYQTRRSLDQVKPFGLLLLLAILWVPELNRVFFDAVYWVFELSGVPSDWAAIGSYLTRFWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB11</accession>
    <name>A0A231HB11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030516558.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46019">
        <property type="protein sequence ID" value="OXR46019"/>
        <property type="gene ID" value="B7C42_00982"/>
    </dbReference>
    <dbReference type="GeneID" id="66717535"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="10622" checksum="C163830926BAF23F" modified="2017-10-25" version="1">MADGSDSDLIAGELRADLLRALSYVETEDGPDGSYIVNGDLPPEVAPPFIRAIMRIEAELLLHDAEQVTVERGEPRSPEERRTDAFVALALRVTDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBC8</accession>
    <name>A0A231HBC8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Porin PorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">porA</name>
        <name evidence="3" type="ORF">B7C42_01210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46244">
        <property type="protein sequence ID" value="OXR46244"/>
        <property type="gene ID" value="B7C42_01210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="379" mass="41085" checksum="2A395CB23EEF9ED0" modified="2017-10-25" version="1">MALSAGTKRTVACLLVGLGALLIVAAILIPTYGVSQLAKTPLDLEITTIASSKPDATSEVLDAKSLTSGEGPVQIDKNVGLISQRFLTVEDPSGKTNMTIQAGQTLRRKDKTGDTGLLSAIIDRVTIDRKTGQPIDDDPNGSIATTVDSKGNSVPDPVQHTGLQYRFPIGTEKTTYPYFDINARESFDMKFVEETEINDLKVYHFRQQVPATDLSKVTSAPTNRLTFPAAKWGVQGEGDVTMNRFYTNTRDVWVEPKTGTIVNGTEQLHQYYARSADKPEVTAINTTLTFDPDTVRSQADEARKYMDQISLYSRTLPIILGVLGAISLIAGLILGLRGGEGSSKPGRLVKKPQSTPPSEKPGQQFSEAPTQQIDISKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBI8</accession>
    <name>A0A231HBI8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46231">
        <property type="protein sequence ID" value="OXR46231"/>
        <property type="gene ID" value="B7C42_01197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="525" mass="55092" checksum="D667BEB172640EEB" modified="2017-10-25" version="1">MAGLPMRPGFYGAELFGLLTPCAHSAAKYGLDAADWRTHMCGLCLGLRDGHGQLARTATNTDAIVLNVLTEAQAGAAARTAAGPCALRGMQRASVAAAGSPGVRLATTASLLLGAAKIRDHADDGDTGPLARRPMRKVADRWFASARANAADIDLDIEPLIAAIGRQTELEQSVRTRSRTADFTPLELLATLTEPAQTCAAELFAHSAVLAGRPENVTALREVGWHFGRIAHVADAIEDLDDDRRRNRFNPLLATGASAEQAHGLLRESDAEIRRALHQAKLAHVPAVRWLLLDPLRGVVRKLGRTAAAACGGVTSACGCGKGGGAALSHDTDTSATARLLGYPVAAVHIRPRAVAPATAGPSTEARIGKAITAQHPFQPGPYPSAPGPYQPNPAGPQVNPAAYPDQGPYPASPVQPYDIPPPFGDRPPSDPYPPADEPPHEPPRRPTFWQGVGIICGVYCTGYACCAGHRRPCSGEHRDAWLQRCDCDCDCCDCGDCEGCGDCCSCCNGCGDCDCDCCGCDCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBM8</accession>
    <name>A0A231HBM8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781542.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46245">
        <property type="protein sequence ID" value="OXR46245"/>
        <property type="gene ID" value="B7C42_01211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="16032" checksum="D110E3237212569D" modified="2017-10-25" version="1">MSTTTDTTAIRALIERSRDAWNRGDGAAYGACFTADATDVTYLGSVYHGGTEIGGAHQALFDSFLKGTRLTVDIVEIRRYGSDTAVVVTRGESSKGRPKKLGKLATYTVVREADGEWRIAAVQKTQRKTLMEALTFRMQPATRPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCE1</accession>
    <name>A0A231HCE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid metabolism regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fadR_2</name>
        <name evidence="5" type="ORF">B7C42_01485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46515">
        <property type="protein sequence ID" value="OXR46515"/>
        <property type="gene ID" value="B7C42_01485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="227" mass="25002" checksum="E4CABDA2773D0AE1" modified="2017-10-25" version="1">MTASAPADRRLPRGRHGIPRETVVRDQRDRILAAMAEAMAAHGYVGTSVAAVIKRAGVSRETFYEQFRSKEDCFEAAYERAVEQLIARIQDTLRPRTDAPAERPIGALLDAYLDGLAAEPAYARLFLVEVYAAGPKAIARRAELQESFVSLVADILDARTDQQRFACRTMVAALSAMVTTHVAADDPDGLRELREPMLELVRRSGDLFGGVPAAPGRADPREHFDPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCN4</accession>
    <name>A0A231HCN4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase</fullName>
            <ecNumber evidence="4">1.1.98.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dprE1_1</name>
        <name evidence="4" type="ORF">B7C42_01560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46589">
        <property type="protein sequence ID" value="OXR46589"/>
        <property type="gene ID" value="B7C42_01560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="496" mass="53859" checksum="5FC920686BA3C8BF" modified="2017-10-25" version="1">MSTKAQTSTAAGPANSAGDGEASQASSNGSADSFSLPTRTRRLTGWGRTAPSTSEVLSTGDPELIAKAVAMVAEDNESKPAYLRRGVIARGLGRSYGDHAQNGGGLVIDMSALNNIHRIDRDTHLVDVDAGVSLDQLMKAALPFGLWVPVLPGTRQVTVGGAIASDIHGKNHHSAGSFGNHVRSIDLLTADGKIQHIGPKKNAKLFWATVGGNGLTGIILRATIEMTPTETAYFIADGIKTATLDETIAVHKDGSEENYTYSSTWFDVISAPPKLGRANVSRGRLAKLDELPKKLRGNPLKFDAPNLLTVPNVFPSFAANKLTLGMVGEAYYALGGNYTGKIMNLTQFYHMLDVVSEWNRAYGSAGFIQYQFVLPPEALDEFTKIIVDIQRSGHYSALNVLKFFGPGNQAPLSFPMEGWNICVDFPVRPGLNELVTELDRRVLEFGGRLYTAKDSRTTAETFHKMYPKIDEWIKVRRSVDPTGVFMSDMARRLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCQ5</accession>
    <name>A0A231HCQ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46680">
        <property type="protein sequence ID" value="OXR46680"/>
        <property type="gene ID" value="B7C42_01655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="368" mass="34714" checksum="E81E9018CE82B2F4" modified="2017-10-25" version="1">MALTPQFLGGVGTAMKDLLIANVASAVASVDINIFGIHLQPFAFLQQWADDLVNQANQAIADASAAQIAADTANSGVSTVASGVTANITGSSSSSNPADVGNSIGILNNTVQSSSQPPQTVIVTTTQDVPIPTGCRTVVMNVFGPSGGGARGGNSGGSGLAGGPSGIGGWQKDISMQASVMTSTLHCVIGTKGLGATSDTTAGADGNGSSYVASADGSVKYCEATAGKGGKPMTTASSSPDWSSLTGAAGSGNGVQTVPGKSGGHGGIRNLFNATDGANGLNVSGGTAGASAGSAGGNGSDDTSTLTPGNGGSGGGGAPGGATGNAGKGGNGGHPGGAAGGGGAFYAVGSNGNGGDGADGEIWLKFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCS9</accession>
    <name>A0A231HCS9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">tgt</name>
        <name evidence="7" type="ORF">B7C42_01708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46731">
        <property type="protein sequence ID" value="OXR46731"/>
        <property type="gene ID" value="B7C42_01708"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="6">
        <location>
            <begin position="36"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="430" mass="47190" checksum="4F13F346ED920548" modified="2017-10-25" version="1">MSDPAQFSFTVGTSLPGRHGGGPPVGHGGGPPVRHGRTGVISTPHGQIATPAFIPVGTKATVKAVLPEAMAEIGAQALLANAYHLYLQPGSDIVDEAGGLGRFMNWPGPTFTDSGGFQVMSLGVGFKKVLAMEAVGVQSDEVIAKGKERLAVVDDDGVTFRSHLDGSSHRFTPEVSMGIQHRLGADIMFAFDELTTLFNTRGYQEKSLRRTHEWAQRCIDEHERLTAERAHRPYQALFAVIQGAQYEDLRRKACRDLDAMRGSGGTGFDGYGIGGALEKANLGTIVGWCCDELPPEKPRHLLGISEPEDFFVAIENGADTFDCVNPSRVARNAAIYVAAGRFNINTSRFRRDFTPIDDTCDCYTCAHYTRAYIHHLFKAKEMLAATLCTIHNERFTIRLVDDIRASIEGGYYDDFKAEFLGRWQGRIRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD44</accession>
    <name>A0A231HD44_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumarate reductase flavoprotein subunit</fullName>
            <ecNumber evidence="5">1.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ifcA_2</name>
        <name evidence="5" type="ORF">B7C42_01829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775610.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46851">
        <property type="protein sequence ID" value="OXR46851"/>
        <property type="gene ID" value="B7C42_01829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="494" mass="52565" checksum="3B29662E95021F74" modified="2017-10-25" version="1">MSDTLGVRPQPAADITDWDYEADVVIAGYGIAGVAAAIEAARAGADVLVLERTGGWGGAASLSGGFIYLGGGTPLQKALGFDDTPENMEKFMLAALGPGVDEAKIHDYCQGSVEHFNWLVAQGVPFKEEFWGEPGWEPPHDEGLMYSGGENAAPFKDIATPAPRGHLPQMQNKRIGEQGGGYMLMKPLTDTAESLGVRAEYDIRIQRLVVADDNRVVGVVAKRYGKEITVRARRGVVLATGSFAYEQRMIEGYAPRLIGRPAAAIEEHDGIGIRVAQALGAELAHMDATEVAFFGDPQMMVRGILVNGRGQRYIAEDTYPGRIGQATLIQQDNQAYLIIDEAALEEALKTETSSPFFRQPPTWAAETIEELESDMGLPAGSLQATVEVYNRHAESGADPLLGKKPEWVKPIGTPVAGFDMRNFTAGFTLGGLRTDLDSRVIHVTGEPIPGLYAAGRCTSGVCAGGYASGTSLGDGSFYGRRAGRAAANDGPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDA3</accession>
    <name>A0A231HDA3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menG_1</name>
        <name evidence="3" type="ORF">B7C42_01723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46745">
        <property type="protein sequence ID" value="OXR46745"/>
        <property type="gene ID" value="B7C42_01723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="75"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="30435" checksum="B8B93FCBE7D826B0" modified="2017-10-25" version="1">MPDTSATPTVEDMAPTHSSSADNSSPSGLRPDRFDRAGRDQLIDVHDLQAALPGIRGLRRWAHDALAVAPGESAVDIGSGTGSEVLVFADAVGPTGDAVGVEPDPNLLAGAEHRAAQHDSPARFVPGDAYGLPFGGETFDVALCERVFQHLTAPERAAREIARVLKPGGRVVVMDSDWGTAIVHPGDRRVVREVIETLITNTTNPFSGRRLPGLLTRAGLVVDDIGSHALVQDASAGAGALVARIAGMAEARGAITAAQRRELLAELEAGARTGDIHLSVTMFAVLAHKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDN2</accession>
    <name>A0A231HDN2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776961.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47040">
        <property type="protein sequence ID" value="OXR47040"/>
        <property type="gene ID" value="B7C42_00159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="7"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="391" mass="43356" checksum="9FB47CF9ED0AFADB" modified="2017-10-25" version="1">MEYGLIDADGHYYEPDDCFSRHIESRFADRTIRVERGTDGLGRIFLRGQRTFMSVMPGDYASAPGALQGLFVGGVADGFTHREVVTSRDHPEFADRSARLAVLDRQGVEATIMLPTLGVAVEYDLRDDVELTYASLRAFNRWLEEDWGYGADGRLFGVPMLSLLDIDQGVRELHRVLDAGARMVHLCPGPIAGRSPADPLFDPFWATVSDAGIPVAFHVSNSGYQHFYGTHWSENPDNPSHQQSPLQWALCNTERPVVDTLIALTLHNLFGRHPGVKIVSIENGSNWLRPLFKTIDKAAALGRRGPMIGGKLPPRPSEALAEHLWVCPFPEDDVHDLIDAIGADHVLFGSDFPHPEGLREPRDYLPRLESCDPTVRHQVLRGNTAGLLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDQ0</accession>
    <name>A0A231HDQ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadA_1</name>
        <name evidence="6" type="ORF">B7C42_00068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46952">
        <property type="protein sequence ID" value="OXR46952"/>
        <property type="gene ID" value="B7C42_00068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="259"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="39594" checksum="2CEB1C21F8435EAA" modified="2017-10-25" version="1">MPDAVVIDAVRTPVGRRNGGLAHVHPADLSAVTLRALTERIGLDPAFVSDVVWGCVGQVGEQTGDIARTALLSAGWPEHVPGVTIDRQCGSSQQAIHFAAAGVIAGQYDFAVAGGVESMSRITMGLAFTLGGDPYAGQGWQNRYGRTAHQGIGAETVARTWDLSRTQLDEYSLRSHARAAAAQDSGAFDAQIVAVETPDGAIERDEGIRRGGTLESLAKLTPAFINNGVIHAGNSSQISDGAAALLITSSDLARKHGLRPMARIHTAVVTGSDPMIMLTGPIPATQKALKSSGLALRDIGAFEINEAFAPVPLAWATDLAADHAVLNPLGGAIALGHPAGGSGARLATTLLHHMRDNDIRYGLQSMCEGGGQANATIFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDT4</accession>
    <name>A0A231HDT4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46928">
        <property type="protein sequence ID" value="OXR46928"/>
        <property type="gene ID" value="B7C42_00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="3">
        <location>
            <begin position="209"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="36124" checksum="CCAB30EF6ACD8A2B" modified="2017-10-25" version="1">MSKQVAADLGVTAVTVGKWRQRFVESRLDGLNDSPRPGRSKAGLMLTEEERSTLQRWARRPKTAQAIAFRARIVLACAEGVTNKQVAAALGTREQTVARWRGRFVRNRLQGLVDEPRPGAPRTISDDDVEQVIVKTLEHVPAGGDTHWSTRGMAKATGLSQSAVWRIWRAFGLKPHLVVTWKLSTDPQFIDKVRDVVGLYLDPPAAALVLCVDEKTQMQALDRSAPMLPMMPGVPARRTHDYVRHGTTSLFAALDVATGKVIGQHHRRHRHQEFLRFLKTIDADTPAELDLHLICDNYGTHKNTRHQQMAGSPPAIPPAFHPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEF3</accession>
    <name>A0A231HEF3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47077">
        <property type="protein sequence ID" value="OXR47077"/>
        <property type="gene ID" value="B7C42_00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14095" checksum="2719189235F7C0AD" modified="2017-10-25" version="1">MKYMLLKTYRPAAHCDTPISEWPPEDIAAHIEFQRALGAALRESGELVDAQGLAFPDQARIVSADGRSAPVVTDGPFPETKEFLAGYWIVDVDSADRAVEIAAQASAAPGPGGAPIGEYIEVRAVMDAPATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HES3</accession>
    <name>A0A231HES3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47235">
        <property type="protein sequence ID" value="OXR47235"/>
        <property type="gene ID" value="B7C42_00357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011195">
        <property type="entry name" value="UCP010256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010256">
        <property type="entry name" value="CoxE_vWa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353204" evidence="2">
        <location>
            <begin position="27"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="496" mass="54704" checksum="5B7247F962704D67" modified="2017-10-25" version="1">MSGKRTTPRALVSAALRGGSASAAQGAPPPGQTAPHGLSGHVVGFVEALRARGIPVGPSETVDAGRVLTVVDLMDREMLREGLACALLRRPTQRATFDGLFELWFPAALGERAGADDIELPRRDDGEIDLFELRGMLAEMLAAEPTGDQTRQLQNLAAQMVEQMGQYQSANGPSFSAYQTLKDVQPEVLISKILAGLAAGQNNSEFDTEVARRAARERVKAFRGTVEAETRRRVAERLGRERVATYGVQRQAEDADFLRISENELAELRRGSQRLARVLASRLAARRRRSRRGEIDLRKTLRKSMSTGGVPITLQTRKPRPGRPDLVLLCDISGSVAGFSSFTMLLVDSLREQFSRVRIFAFVDQVDEVTHIFDQVTPLDQVTRRIFTETEVVGFEGHSDYGAALRGFAQDWPDVVTSRTSLLILGDARTNYRDPALNTLHELVQVAKHAHWLNPEAEKMWGTGDSAANRYAEVVEMHECRSARQLTGVVSRLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEX3</accession>
    <name>A0A231HEX3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glnD</name>
        <name evidence="10" type="ORF">B7C42_00638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47513">
        <property type="protein sequence ID" value="OXR47513"/>
        <property type="gene ID" value="B7C42_00638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="434"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="620"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="728"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="812" mass="87195" checksum="484343F37ED2FA08" modified="2017-10-25" version="1">MSADELSQGAKDLVAARDQLLDGGDPRRPRLSAEALRQALVDLHELWLTTKGAELGITADSGLAVVAVGGLGRREMLPYSDLDLMLLHDDVDPARVAEVADRLWYPLWDAHIKLDHSVRTVPQALRVAADDLTAVLGMLDARHIVGDAELSNLLIGGVRREWRTGIRSRFGELVEQTQARWKRNGEIAHRAEPDLKSGRGGLRDIQLLDALAIAQLTDAMPGLGPDVPGGGLEAAHRRLLDVRTELHRVAGRSRDQLRAQDADEIGAALRIGDRFDLARTLSDAARTVVYSVDVGLRTAGNALPRRGLARLRRLPVRRPLDEGVVEHAGEVVLARDARPQRDPGLILRVAAASARTGLPMSATTLSRLSEDAPELREPWPREALNDLLVLLGAGRNTIDAVEALDRTGLWGRLFPEWGAVRDLPPRDAVHTWTVDRHLVETVAYASALSTRVARPDLLLLGALLHDIGKGRTEDHSVVGAELADRIGHRLGLWPDDVRSLATIVRHHLLLPETATRRDLADPATADRVVDALDGDRQLLDLLHTLAEADSLATGPGVWGEWKASLIGELVRRGHAAMAGEPAPQRVSPTPTVVDAAVLAKAAAGGVHVELTPGDGRYIHVVTVVAPDTPGLLSEAAGVLALHSLRVLSATLAASGDTAIDTFVVTPTFGNPPDAGLLRQELIRAINGDLKLASVLADKEREAAVRTSRYAQAQPRVIWIEADRPGEVVLELRAEDRIGLLSRLAAALAAHGADVRWAKADTMGSVVVDSFGLGLGEGDTPQRRRAIEAALLGVVPHPEPKKPSETDTATDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF04</accession>
    <name>A0A231HF04_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cdsA</name>
        <name evidence="10" type="ORF">B7C42_00668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47543">
        <property type="protein sequence ID" value="OXR47543"/>
        <property type="gene ID" value="B7C42_00668"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="32374" checksum="45947102336F9AB6" modified="2017-10-25" version="1">MSDGTIVAEEAAAGETMPASDPAGATPAPDTPSAQPSGKPSRAGRNLPAALAVGVGLGASLIAILLFVPKVLIGVIAVAMAIATWEVAKRLREADVLVPRVPLIVGGQAMIWLAWPYGTQGVAGAFAATALVCMVWRLFDHGLAATPRNFLRDTAITVFVVSWIPLLASFAVLMLQQDDGNLRVLTFMILVVCSDVGGYVAGVLFGRHPMVPAISPKKSWEGFAGSLVFCIIGGLLTVTLLLQANSMIGVLLGVAVVLVATCGDLIESQIKRELGIKDMGTLLPGHGGIMDRLDSMLPSAFVSWLVLTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFF5</accession>
    <name>A0A231HFF5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47548">
        <property type="protein sequence ID" value="OXR47548"/>
        <property type="gene ID" value="B7C42_00673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="479" mass="52947" checksum="D5833D06D562FC38" modified="2017-10-25" version="1">MLLLRDARTRAKNEALLDEHTRLVRSVLDGTADLDGVHAAKLLRTVRAAAGSPMYEGRLPADLLTEIDAGTTISDERVLTEILPSLPLLGKRELGRFGAEAFTRPLNEFLHYYESSGTTGDPAAAPKALDDLLVNTVNIGEMWARLLQPKDIALILINAPFAPAAYQFEKALEYLEVMSLRPWVDNITGDYTRVLRLVDQLGANVFVGPPSRLLEMVQFAHRNDLPAPRFDRLLLMAEQTGPSFRRHLERLTGAQSYVSSYGSSETGTPAVTCEQGQLHLQPQSFLLELADDNGIRRIGNSSDRGELVLTTLDLPARPLLRYRTGDLVEIDATPCPCGVRTPVLLTQGRSQDLLVLDRNGIRQNDLEAAVWEQPLPAATVFNYMVVVRGRQVVFLVTYDGDPAGPWTDVLTGRLRELFGREEVTVRPVPVLPPLASLGQYLGWKLSRVLDLDDEKNWDRLPAPIDAVVRQTIAELAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFI2</accession>
    <name>A0A231HFI2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47435">
        <property type="protein sequence ID" value="OXR47435"/>
        <property type="gene ID" value="B7C42_00558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="49" mass="5280" checksum="8482C868AE27A199" modified="2017-10-25" version="1">MDGGTTFHFVDDTSENVLDQAFSAAGGKDIRLGGYSFHESERLTGQRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFK1</accession>
    <name>A0A231HFK1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 8-oxo-dGTP diphosphatase 1</fullName>
            <ecNumber evidence="6">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mutT1</name>
        <name evidence="6" type="ORF">B7C42_00580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47455">
        <property type="protein sequence ID" value="OXR47455"/>
        <property type="gene ID" value="B7C42_00580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="38092" checksum="F0A5DF676C9027E2" modified="2017-10-25" version="1">MKSSATRDFDRSPDDGDTALDRPGDTGGSMSDGKVDAGESSSGDTISDPRVTANIIAAGAVVWRRPRDGGPVEVALVHRPKYDDWSLPKGKLDPGETPMVAAVREVAEETGLNCRLGRYLGRVTYPVPGHRKLKRVDYWAATPVDGEFVTNSEVDQLRWHRVDRVMDQLSYPMDRRIIRNFLRLPPDTATLVLVRHAKAGRRDRFTGPDDERPLEKAGRAQVQVLTPNLLAFGPGAVYSAPPLRCVQTVAPVADALGLDIAREPLLSESGYAAAPQAGVDRLRELVSPDIVPLVCSQGKVIPDLLQRWADDDGLTLPPARNRKGSVWVLSVADGRLVAADHLDRSLRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFK5</accession>
    <name>A0A231HFK5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042828.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47619">
        <property type="protein sequence ID" value="OXR47619"/>
        <property type="gene ID" value="B7C42_00744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="41630" checksum="7F029AF8A2A16FAC" modified="2017-10-25" version="1">MAGIDGHPAHQAPVPLDEYPVHQTPLSLARAATTDRNFYDRSYFNAHDRSGGTMLVTGFGVYPNLGVIDAYAAVRRGDIQRTVRFSDALPPRDLNMSVGGYRIEVIEPLRRVRVICEHDDLSFDLTWDGSFPAVQEQPHLIHTGSRPIIDASRFAQVGSWSGTLHVDGDDIAVDPEIWMGTRDRSWGIRPVGETEPPGRDASEPAAGFWWLYVPLRFDDFAIVVIVQENPDGFRTLNDAVRVWPDGRVEQLGWPRIHLEYRSGTRIPVSARLDMTAGDGSPLTVEVRAHTCIPLHIGCGYGGDPDWLHGQWKGRDWSSSSRYDLTDPAVAGRIPWGVIDHVGQARCGDAEGWGLFEHGSLGRHDPTGFADWTSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG34</accession>
    <name>A0A231HG34_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-nitroanthranilic acid aminohydrolase</fullName>
            <ecNumber evidence="2">3.5.99.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">naaA</name>
        <name evidence="2" type="ORF">B7C42_00969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.8" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779650.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47844">
        <property type="protein sequence ID" value="OXR47844"/>
        <property type="gene ID" value="B7C42_00969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="221"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="447" mass="48172" checksum="5E271CCF40517162" modified="2017-10-25" version="1">MTIAEADALAGLDAQRRRWVEAACARVNRKRLCELLSGLIDIPSPTGDEAPLARHITATLAAADIESHTMYLDDRQANAWGRLRGDGTGPDLLLYAPIDTVTTGSPDEDLPWAGESLRADMVAHATTVDDYVVGLGASNPKGHTACILAAAEAIRSAGVPLTGDLLVGFGAGGMPTNARPGVGNSRRNTGQGVGCSFLLEQGVWADFALIAKPGWTVSWEEVGLAWFEITVHGSHTYVGSRHRLPYRNPVALAGEVANLLEEWFPHYSQAHDDGLVRPQGMVANIRGGWERTASFTPACVRMMADLRLSPRTTPTAAKREIVQAVRRIAADLQIRVDVEQILAIPGEASDPRMWLSRKAVEAWEAAEAAPHREFRDASGATDANILRGRGIPTVRVGMPKVADAPFDVDFAMGMNTVDLREAEKLTRYLVRVALDTVTHSLEEVGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSM9</accession>
    <name>A0A231GSM9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000232">
        <property type="protein sequence ID" value="OXR39588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39588">
        <property type="protein sequence ID" value="OXR39588"/>
        <property type="gene ID" value="B7C42_08344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="61" mass="6542" checksum="4A83803AB4F0D2AC" modified="2017-10-25" version="1">MAVSRTSTSLTIESTRDRPVRTSTSVTSASHWADNRGDSSGTGRISAGLPSMRATRRSMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSN5</accession>
    <name>A0A231GSN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000118">
        <property type="protein sequence ID" value="OXR39633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39633">
        <property type="protein sequence ID" value="OXR39633"/>
        <property type="gene ID" value="B7C42_08299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="73" mass="7093" checksum="4700AB41AD5AD5AC" modified="2017-10-25" version="1">MPGDGDVLAPGGMGFAAFGVLVASPDACAVAADVPATVVVVAGVVVSDPQPDNAAVAASATIEIDRGRTARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSY3</accession>
    <name>A0A231GSY3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000077">
        <property type="protein sequence ID" value="OXR39730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39730">
        <property type="protein sequence ID" value="OXR39730"/>
        <property type="gene ID" value="B7C42_08200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="90" mass="10304" checksum="472896C8DC8F7BC4" modified="2017-10-25" version="1">MSPERRELLSSDLDRGFRIATQVSEAADLIKTYADTADDLELAEFAHQFATELRTECMLRDRAQLLATDKPRMSWAEFSARHRVGTSTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTC6</accession>
    <name>A0A231GTC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39870">
        <property type="protein sequence ID" value="OXR39870"/>
        <property type="gene ID" value="B7C42_08045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8784" checksum="97E061A67735F4BF" modified="2017-10-25" version="1">MDVDQRAQDEYNERVDEALDETVWVHPGAQVNGYYRNSAGRAVVPCPWRLVDYWTMLRTPHPEDLTFLPHRKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTI3</accession>
    <name>A0A231GTI3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39926">
        <property type="protein sequence ID" value="OXR39926"/>
        <property type="gene ID" value="B7C42_07989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="30688" checksum="839C3D4993A17977" modified="2017-10-25" version="1">MRSAHVVSRTRRPVLLDLFCKEGGASMGYHLAGFDVVGVDMEPQPRYPFEFHQADALEFLEQHARDFDAFAGSPPCQLYSNTQRLRGREHPDLVGPLRESFQRLTGGRPWVIENVPGAPLHAPILLCGAMFDQLRVYRHRLFESNIALPVPEHPAHRVKVTRMGRPPAADEFMHVVGNFSGVAQAKTAMGIDWMTRDGLREAIPPAYTEFIGHRLLAALDKRQACNETRCHAPGCRTLIVQPSTGRPRRFCCGACRVRAHRAPKLLPMSAAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTM0</accession>
    <name>A0A231GTM0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782318.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39895">
        <property type="protein sequence ID" value="OXR39895"/>
        <property type="gene ID" value="B7C42_08041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="13631" checksum="AAFE6FE5EADC11FB" modified="2017-10-25" version="1">MTDKPTVAEVAAGLALEKIRDQIEPRITAAVTETREAAQRQITEWLQSGAPAAVSGAVDGKADARDRAQRTAIQGAISTVVVAILLAVAGVIGGAGFDFTDAGDWKAVGGAAIGAVVTVVTAYLHRLVKPPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTP3</accession>
    <name>A0A231GTP3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000057">
        <property type="protein sequence ID" value="OXR39851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782469.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39851">
        <property type="protein sequence ID" value="OXR39851"/>
        <property type="gene ID" value="B7C42_08075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="620" mass="65898" checksum="A7E8B6820527EEF6" modified="2017-10-25" version="1">MTADTGAQAPFDEALPSPLRSLRALRADARDAVVALGAQTGAQATTYVASAVDDAITELASSSPVPHAIVIAGSAGGGKSGCAERQRQAAPNLFSDIVEDATHSDRPSEDQADTLARRLAPLADCAGARPERPVLIAANTGMIVQLAAAWTEPRRGHAFDGLIRRLFLALGLPGAPDDPRDALPLDVRVLNLDDRPTSGEGGLLRGMLPMLRPAATGTAFPDERCATCAAIAYCPARANAELLATVGVDVVDRLASRAAVERARQDTPRALWDFLSRMALPDSHYASDEDPCAASARAYRDSDAGWVVSGLVPLTMFRAGGDVGRRVARLDPARQPRRETYDAFAGAGLMPEDDAEPLRRLADHARSAGCDEAAIATAASALAQGVADGADEREWRDAAAHIKLGVAVLLGELVPDDDPAERPFLQALALYERWQRLEADGADTSAVLEEMEDPFDLLVTQLANGLARMFGETHDDRTFLPVRNYDPREASRAFVEFQLHVSTAQPELDRATAANHEGTRLIGYRPMAVSLQLEAGISVNVDLPTYRLLDATRKGLAGGSGDAERTFALRRASEAIARATAESEGVAMLVTDPGTSRRYLVTTQAGLGGRLNLRARAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU07</accession>
    <name>A0A231GU07_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome b6-f complex iron-sulfur subunit</fullName>
            <ecNumber evidence="5">1.10.9.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">petC_2</name>
        <name evidence="5" type="ORF">B7C42_07837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.9.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40082">
        <property type="protein sequence ID" value="OXR40082"/>
        <property type="gene ID" value="B7C42_07837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="420"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="488" mass="52281" checksum="1D75905F69F58DA0" modified="2017-10-25" version="1">MTSLWLDRAPISVPVTPEPDGEYDCVVVGAGLTGLVTALLFARAGRTVAVLEGRTIGAVTTGNTTGKLSLLQGTHLSAITAKHSASTVRHYVDANLEGQQWLLRFCAENDIATQHADAITYAGTEDGTDLVRKEFRACEQAGLDVAWAEETALPFHTHGAVRLAQQAQFDPMDVLEGLTLQACRHGATIFEHTRVHAVHGDTVSTDRGDIRAGTVVLATGTPILDRGGYFARLEPHRSYAAAFRVPGEFPHDMYLSADQPTRSLRYAPHAGEDLLLVGGSGHVVGRTRSAMAHVADMYNWTRTHFPDAELTHRWSAQDYSAIDQLPYVGPLLPGSDHILVATGYAKWGMTNAVAAGLALAGTALGGHQPWAQAYRTWRGSEVTGLAKAASLNIQVARHLTTGWLSAAFGGGGTPAEGEGRVERRGIRPVGVCAVDGTTSAVSPICPHLYGILNWNDAERSWDCPLHGSRFTHDGKLLEGPATRDLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU49</accession>
    <name>A0A231GU49_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
            <ecNumber evidence="2">5.3.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylA</name>
        <name evidence="2" type="ORF">B7C42_07820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778474.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40112">
        <property type="protein sequence ID" value="OXR40112"/>
        <property type="gene ID" value="B7C42_07820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013457">
        <property type="entry name" value="Rhamnose_iso-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02635">
        <property type="entry name" value="RhaI_grampos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="66"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="387" mass="42342" checksum="61B79C9E9522F94D" modified="2017-10-25" version="1">MAVTSDAVRAALRELRIELPSWAFGNSGTRFKVFAQAGVPRDPFEKIADAAQVHRYTGAAPEVSLHIPWDATDDYRQLGAFAVDHGVSIGVINSNTFQDDDYRLGSVCHPDPRVRRKAIDHLLACVDVMDATGSRDLKLWFADGLNYPGQDDLRARQDRLAEALSEVYDRLGPEQRMLLEYKLFEPAFYATDVPDWGTALLHCLRLGERAAVVVDTGHHAPHTNIEFIVALLLREGRLGAFDLNSRFYADDDLMAGAADPFQLFRIMNEIVAAGAIGGEVRFMLDQCHNIEPKIAAVIRSVMNVQEATAKALLVDRAALHTAQQEGDVLGARAVLMDAYDTDVRPLLAESRTEMGLDPDPIAAFARSGYAESVIAQRVGGAAAGWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUA3</accession>
    <name>A0A231GUA3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821216.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40199">
        <property type="protein sequence ID" value="OXR40199"/>
        <property type="gene ID" value="B7C42_07713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="567" mass="63950" checksum="7F3420CE1B23DD02" modified="2017-10-25" version="1">MTDQQTATDPASLGPVRETAADRRAMPNLYDIAQAAADKHGECRRPIPMYSFDPDTGESKYVGAPCKSTLESVCPSCAARARALRMQQAHEGWHIETEPVDDKRDPTERQLELVEARASLMDLYQDAKARDDHDEMAGIREVVADLDAELRETGVRGRLPALDPAPKSERKRSTRRRQDVPDLPRKKVDKSTIGRQYAGKYRPSIFLTLTCDSYGRMNGDGAVNSKGEPCGDGSPVDPDTYDYRRAARDIVFWPALFDRFVQNYRRATGRDIQYFATVEPQRRGAPHIHMAIRGTDPRELIRQIVAATYHQVWWPHFDPENEQYTDGHMPVWDYSAGRFVDPDTAEPLPLWDEAMDMLDLVDELEPAHVVKFGRQVDVQGVLGGTEEASRHVGYLTKYLTKSIAEVIEPQTDRAAQHYERLHAELQKVPCSPNCPIWLRYGIAPKGASDKTQPGRCKGKAHRRETLGLRGRRVLVSRRWTGKTLPDHKADRAEFVRQILASVGIQRPDPSRLIVKPVEPGDKNVPPREHLIMASIAQRIKWRAQYETARLAASPPGEQQHSAIQNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUN9</accession>
    <name>A0A231GUN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40343">
        <property type="protein sequence ID" value="OXR40343"/>
        <property type="gene ID" value="B7C42_07604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="45" mass="4808" checksum="E3700AE02DBF549B" modified="2017-10-25" version="1">MMIGTTEEITDFLAAVEKLRDDEGAVRTTAHTSSIIAAGWPSSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUT2</accession>
    <name>A0A231GUT2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40241">
        <property type="protein sequence ID" value="OXR40241"/>
        <property type="gene ID" value="B7C42_07666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="7056" checksum="756440B342EDF4BE" modified="2017-10-25" version="1">MAKAYRSARTGRYVSKATAARHPRTTVTESGSNRSNGVHHRSAISGRYVTGATAARHPSTTVTERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV37</accession>
    <name>A0A231GV37_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-carnitine dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lcdH</name>
        <name evidence="1" type="ORF">B7C42_07473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.108" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042669.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40415">
        <property type="protein sequence ID" value="OXR40415"/>
        <property type="gene ID" value="B7C42_07473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047728">
        <property type="term" value="F:carnitine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19948" checksum="CA6764E4569BF05B" modified="2017-10-25" version="1">MISPDALPLGQVPQGPVTSYRCRVEDSWIDFNDHMNAMYYGIVVYQGQERFSTLIGMGADYTERTGLGKVVVQSTLGFEHEMRRGDDLEVRSWLLGVDDKRLHVLHEVFSITDGRRAAVSEQLDLHFDLASRRTCPMPPEQREYLNRFSHTQISGGLPAGIGRRVCGPSARDAAPGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV55</accession>
    <name>A0A231GV55_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgm</name>
        <name evidence="13" type="ORF">B7C42_07424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40486">
        <property type="protein sequence ID" value="OXR40486"/>
        <property type="gene ID" value="B7C42_07424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="40"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="209"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="320"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="488"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR40486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="551" mass="59128" checksum="DB147F017231409A" modified="2017-10-25" version="1">MAHDRAGRPARASDLEDLPHLVTAYYSRIPDPAEPAQQVVFGTSGHRGSSLDCAFNEAHILAITQAIVEYRATRGITGPVYLARDTHALSEPAWTTALEVLAANDVTAVIDSRGRYTPTPALSHAVLRHNRGGTRHQADGIVVTPSHNPPRDGGFKYNPPHGGPADTVATDAIAERANELLRGGLAGIKRTTLQHALATGVQRYDYLDQYIADLPAVLNLDAVRGAGIRLGADPMGGASVDYWEEIGQRYDLELEVVNPFVDPTWRFMTLDSDGKIRMDPSSRYAMASLVAIRDDYDISTGNDADADRHGIVTPDAGLMNPNHFLAVAIEYLVANRMGWDALTKIGKTAVTSSMIDRVVGVLGRQTHEVPVGFKWFVPGLFSGSLAFGGEESAGASFLRHDGTVWTTDKDGILLALLAAEITAVTGQSPSARYAELEKRYGTPAYARIDAVANAEQKRRLAALTPDDITTTEIAGESVLSVQTRARGNGAALGGVKVTTENAWFAARPSGTEDKYKIYAESFEGPEHLARVQAAAEEVVGRALGIEEPAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV97</accession>
    <name>A0A231GV97_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40475">
        <property type="protein sequence ID" value="OXR40475"/>
        <property type="gene ID" value="B7C42_07413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="10993" checksum="4D4D3E00909AF073" modified="2017-10-25" version="1">MTAAVSEDELAGDIVAAIESVPGLRPAVPAGVDLADWVPRLGPRSAVDVSAEVVEIRVIASALPLPPLLDKLAAAVGELQAATRWAGARLRIVVTDLDAEAFDTAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVF5</accession>
    <name>A0A231GVF5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909785.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40610">
        <property type="protein sequence ID" value="OXR40610"/>
        <property type="gene ID" value="B7C42_07295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="120"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="35799" checksum="2B37D94525400188" modified="2017-10-25" version="1">MSNARRLIYASLKLAVSAIVIIVLLVVIVQAVQRPVQGGTTEYSAAFTDVNGLKSGDDVRMDGVRVGKVDAIRLDKGRAVVKMHLQNGHHLYESTVLAIRYQSLIGQRYVDVQQSSGLADKLASGSVIDVSKTIPSFDITSLFNGLEPVLGELSPGAINKFAENMISVIEGNGSGVGSVLDSVQTLSSYAVDRQALITTLVANLKQISDHIGGHSAQLIRLVSELSTVVNTLRSKVDGIVEFALMAPDVIAPLNSLLASFGLTTGSNPDADSLLRTVLPDPEQAVDVLRKLPTLIQTLDAWVPPNGPTVNLNCSNGKVAAPSPFQILVGGQRISICKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVL7</accession>
    <name>A0A231GVL7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043580.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40669">
        <property type="protein sequence ID" value="OXR40669"/>
        <property type="gene ID" value="B7C42_07227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="15021" checksum="835D627BAA2A07CB" modified="2017-10-25" version="1">MTATQHGTPNGRSDTRHAVAAGTSLAAAALLAVTGVVSILQGVSAIAKDDVYVSGPDYIYKFDISGWGWIHLILGVLMVAAAAGLFTRSTWGQMLAIALLGLSIIANFLWLPHYPWWSILVIALDIVVIWAIATWDPHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVN1</accession>
    <name>A0A231GVN1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40615">
        <property type="protein sequence ID" value="OXR40615"/>
        <property type="gene ID" value="B7C42_07300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="211" mass="22469" checksum="5EE945AF5CD43658" modified="2017-10-25" version="1">MLTETVAETDEREKESPAKSRNTGKVKAAERREGASRGVTFSIGMRSILVGGVIAVLIVALSATIPLWLTARGELHDRDVAAAAQKHAERVASDYAIGASNIDYHNFDNWVHSLKSNTSPALSNKFDATAPQLKDIIVPLNWTSKATAISSALKSENAGVYVVNVFLNVTSTSAQTPEGAQTTVTYTVTVDKNSDWKITDVGGVDAALPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVP5</accession>
    <name>A0A231GVP5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782249.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40658">
        <property type="protein sequence ID" value="OXR40658"/>
        <property type="gene ID" value="B7C42_07215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="14090" checksum="59FB5418AE4C1273" modified="2017-10-25" version="1">MQREHEEAMRAEFAEKVALERTMFNAGVTDAEFDRMSRRSNDIDNRWASGPHAEHWAFLGDAHHDWQHNPETMERFRADIAHNLATDGHVGLSDVQVRSLEQARTLTQQQSQQAERPVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVQ1</accession>
    <name>A0A231GVQ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation initiation inhibitor protein Soj</fullName>
            <ecNumber evidence="3">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">soj_3</name>
        <name evidence="3" type="ORF">B7C42_07257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40699">
        <property type="protein sequence ID" value="OXR40699"/>
        <property type="gene ID" value="B7C42_07257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="71"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="34597" checksum="F1181A51458FAA3B" modified="2017-10-25" version="1">MTTAGPAEPPNSAAAEPLSNIRTGLRIEQAARRLWEANDIVADGTELGPTGRPLRDIPEPPPSSRNGDALIVAMCNQKGGVGKTTSTINLGAALAEYGRRVLLVDLDPQGALSAGLGVAHHDLDLTVHNLLVGGRASVDDVLLNTKVDGMDLLPSNIDLSAAEIQLVNEVGREQTLGRALAPLRDRYDYILIDCQPSLGLLTVNALACADGVIIPMECEYFSLRGLALLTDTVEKVRDRLNPRLALSGIVVTMFDARLLHSRQVMARVVEVFGDLVYDTVINRTVRFPDASVAGEPITTWAPKSGGAEAYRAMAREVIHRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW06</accession>
    <name>A0A231GW06_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-dependent NADPH-azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azo1_2</name>
        <name evidence="2" type="ORF">B7C42_07088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40804">
        <property type="protein sequence ID" value="OXR40804"/>
        <property type="gene ID" value="B7C42_07088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="21251" checksum="BFE2B4A2902BB508" modified="2017-10-25" version="1">MSSSTLRLAVVIASVREGRFGPVVGEWFAEQARRHDGFEVDLIDLADADLPVALPAVSPRIEPNPQRPAGMLDLTARLDAADAMVVVTPDINNSYPASIKTAIDWHYTQWDRKAIGFVGYSGASGGLNAIAHLRQVFAELNAHTIRDYVSFPRYYQQFDAEGRWTAPSESEAAAAGMLDQLHWWASALAAARVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW09</accession>
    <name>A0A231GW09_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator KmtR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kmtR_2</name>
        <name evidence="2" type="ORF">B7C42_07229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40671">
        <property type="protein sequence ID" value="OXR40671"/>
        <property type="gene ID" value="B7C42_07229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13908" checksum="92F1C4C7C0B2D477" modified="2017-10-25" version="1">MNQPMTGEETPAVDALPPSLVHLVAPDPARLEAATSVFRMLADPTRLHILWVLADGEADVTALTEACGGSRTAVSQHLAKLRFTGMVETRREGRRIIYRIRDGHLARLAREGLNLADHIVTGELPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD9</accession>
    <name>A0A231GWD9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nickel-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nikA_3</name>
        <name evidence="4" type="ORF">B7C42_07051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40916">
        <property type="protein sequence ID" value="OXR40916"/>
        <property type="gene ID" value="B7C42_07051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257564" evidence="2">
        <location>
            <begin position="27"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="90"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="551" mass="60240" checksum="A7726945DE9A308D" modified="2017-10-25" version="1">MSHRRIHRRPVALALALLTAVVVAGCATPARQVAVSDDNATPVPGGTLRFGVLDAPANLDPHSGSSYPESLITSNITDKLVYQNPKTGALEPWLATSWQYNDTLTQFTFHLRDDVTFSDGTKFTADSVKENFDLLGRGDQRLGIVPVTAYWVGYQGTEVVDPTTVRVSFDRPSAGFLQALSLYFSGIVAHSTLVLPKEQRSQAQNVVGTGPFTLAQHVYQQKTVLKKRPGYHWAPASRKHNGDAYLDAVEIDVIPEAGVRTGALRSGTVDAILDVNNTDEAPLQAQGYRIVPQLIPGRDISLDFKTDRFPTDDKAVRQAVQLGWSRDALVKTVLTPSYKVSSSVVSERVPGYVDFSADLREDQGKAEQILEADGWHKGADGIRVKDGRRLQLDLLGIDNLVNNKPAYQLIQQDLRKIGIDLQLNVLPIPDYTAASTQQGRWNIQVANQSRADISVLEQVYSPQYGNMAKLAPGSPEANEAVAKLSALSKTLDTAQRAKAAAEAQRYLLDEQVLTVPVYNPAQVTAAGAKVHNVGYEAQSRNVFYDTWIEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWP0</accession>
    <name>A0A231GWP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic di-GMP phosphodiesterase Gmr</fullName>
            <ecNumber evidence="4">3.1.4.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmr_2</name>
        <name evidence="4" type="ORF">B7C42_06985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.52" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41019">
        <property type="protein sequence ID" value="OXR41019"/>
        <property type="gene ID" value="B7C42_06985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="134"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="209"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="292"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="434" mass="46310" checksum="DD9A6C292EBD7084" modified="2017-10-25" version="1">MCMTGDTGIGELARRWRIAIADTGFVPMSMRELEQLLAGLLEQLVAIVGAEPFDAAAAATIGAALVRANLTDPQVMPRSARALTPLATSVFPPGDRVLAVLGEMARGYTEELLATRARHQEMLHSAMADARNAAEARFRVVFDNAAIAIGIGDAEGRVVDVNPAMATMLGVSREYLLERGVTDLIHPDDRVELRRRVLGELLHAGSGTVRMELRYPRPEGVDGWAAWAITLVPATGGRAAYLLVVGEDTTQRRELQAELHRQARLDPLTGLPNRRQLVEALSAIIADAGAEDCIGLCFIDLDGFKSVNDTYGHGVGDRLLAAVAERLSAAVPALMLARVGGDEFVGLVRPTCDTEHIAAVAQRLLDALAEPIPVDNHDLMISACIGAIVTPVIGTDAERLLDAADAGLYRAKASGRNRWVLHAADVAARVRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWV3</accession>
    <name>A0A231GWV3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41097">
        <property type="protein sequence ID" value="OXR41097"/>
        <property type="gene ID" value="B7C42_06867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="13867" checksum="916A4E2B4A08D553" modified="2017-10-25" version="1">MTINQTSVSLDDAQRVIAAGQAKAAEIESPSNIAVVDAGGNLVAHVRMDGAWIASIDISINKAFTARALDISTEDLAADAGPGEQFYGIHTSNGGRIMIFAGGVPLRRNGQVIGAVGVSGGTGEQDKAVAEAASTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWZ6</accession>
    <name>A0A231GWZ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Erythronolide synthase, modules 1 and 2</fullName>
            <ecNumber evidence="7">2.3.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eryA_3</name>
        <name evidence="7" type="ORF">B7C42_06724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.94" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41129">
        <property type="protein sequence ID" value="OXR41129"/>
        <property type="gene ID" value="B7C42_06724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047879">
        <property type="term" value="F:erythronolide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3084"/>
            <end position="3159"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1427"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="3119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="3241" mass="338366" checksum="3EEC9DEBA3A94977" modified="2017-10-25" version="1">MADDIKHLDYLKRLTVELRHTRQRLREMEDRKSEPIAVVGAGCRFPGGVRSPEDLWRLVSDGVDAIGAFPDDRGWDVDGLYDPDPEARGKSYTRSGGFLYDAAEFDAAFFGIGPREALAMDPQQRILLETSWEALERAGIDPSTVRGSDTGVFAGAANGEYADLLHDGPVDLRGYLLTGTTGSVVSGRVAYALGLEGPAVSVDTACSSSLVAVHLAVRALRSGECAMALAGGVTVMGSPGMFVEFSRQRGLAPDGRCKSFAAAADGTGWSEGAGMLVLERLSDARRRGHRVWAVIRGTAINQDGASNGLTVPNGPAQQRVIRAALADARLSPGDVDVVEAHGTGTVLGDPIEAQALLSTYGQGREPDRPLWLGSLKSNIGHAVAAAGVGGVLKTIMAMRHGAMPPTLHVDEPTPRVDWSAGAVELLTERRDWPAEPDRPRRAAVSSFGISGTNAHVILEQAPTDEPAEAADAGPESIVAQTFPWVLSAKSEASLRAQAERLREFLIADPALSVADVAYSLVSTRAVFDHRAVILGDDHASMLDRLAAVAAGEPGSGIATGVAAPARVAVMFAGQGSQRTAMGQQLYQRFPAFAEAFDRICAQLDPLLGCSLREAIDSGADLDRTWLTQPALFAVEVALYRLLETWGVTPEVVFGHSIGEIAAAHVAGVLNLSDACALVAARGRLMQELPSGGAMLAVQAGAAEVAELLDGLDGVDVAAVNGPAAVVISGHAERVDELAELLRARGRRVKRLRVGHAFHSALMEPMLERFAQVVETLRFDPPRIPVISTVTGAVADPELWCSPRYWVDQVRLPVRFADAAAAAWAQGVDTFLEVGPDAVLSAAAADCLPDDAATVPALRADRDEPADLLAAAARLFVRGVPVRWNAVFAGRNPRQVELPTYAFDRRHFWLETSSGPADVGAAAPAGNRDRSPETLLRIEWVAAARSTRIVDPERIAVVGWNAANVRSYPDAAALIADLDAAADSAVPDIVLWKCPTFEGPPPLAARRVVAELLETVHLWLRDARLTGSRLVVVTDRAVSVDASEAVNLAQAPVWGVVRAAQAEHPGRFQLLDVDHDVWEQSARTLAKYAFSTGEEPEVALRGEAPSVPRLRPHDAASAIPALGSGTVLVTGGTGGLGALLARHLVVNHGVTHLLLASRRGSVAPGAERLRDELVDLGAQVRIASCDVSDRDALSGLIGGISDEHPLIGVVHAAGAADNGVVETITAERLDPVFAPKVDAAWHLHELTRDRSLSLFVLVSSAGGLVLAAGQANYAAANVFLDALAVHRRAAGLPATAIDFGLWEATGLGALLSDGDVARIRRQGLPPLTAAEGLALFDLAIATESAQVVAARIDTAALRDRGDERPALLRDIAPATAGDRVPARTSGGVPADESAALDLVRSVTAEVLGHTSADEVDPRRTFQQLGVDSLGGVEVRKKLGAAVGLHLPATLVFDYPTPQVVARFLAAELSGGVGVDESVADRPRTGDDPIAIVAMSCRYPGGVSSPEDLWRLVADGVDTNGDLPVDRGWDIESLYDPEPGTPGKTYARTGGFLYTAADFDAEFFGISPNEARAMDPQQRLLLETSWEALERSGVDMASLRGSSTGVFAGMSFHDYPGSANSGSIASGRVSYAFGFEGPAVTVDTACSSSLVAMHLAAGSLRSGECDLALAGGVTVMATPETFVEFSRQRGLSPDGRCRSFADAADGVGWAEGVGVLVLERLSDARRNGHEVLAVIAGSAVNQDGASNGLTAPNGPSQRRVIRQALANAGLSPADVDAVEAHGTGTTLGDPIEAQALLATYGQGRDPGSPLWLGSLKSNIGHAQAAAGVGGVIKMVMAMRHGVLPRTLHVDRPSTKVDWAQGNIELLTESVSWPEVDRPRRAGVSSFGISGTNAHVILEQAPDTGSRPATTVPADAVLPWVVSARTGVALADQARRLASHLAARDHDPADIGFSLATRAVFDHRAVVISAERDALRAGIRALGRGEPAPGVVSGRATPGTTGMVFSGQGAQWAGMADGLRSAYPLFAEHFDATVGELEQSLGQQVSLSDALADDDLADYTVFAQAGLFAFEVALYRLLESWGVRADVVAGHSIGEVAAAHVAGVLSLEDACVLVAARGRLMQALPVGGAMVAVGASEGDVLPLLGAGVSIAAVNGPSSVVLSGAEAAVTAVLEASAERGWRTKRLRVSHAFHSSLMEPMLSEFASAIAGLTFARPAFPLVSTVTGRQVGDEMCDPAYWVGQVRDAVRFADAVSAMAEMGVSRFAEIGPDAVLYPMVDQTLDGRAAPHAPAVVALAHRGRADATTVIAGVAGLFVTGAEVNWAGLYAGTGSRRIDLPTYAFQHQRYWVNAAPPAADGGARALGFVDTGHPLLSAMVSQPDSGAVTLSGRLSVRTQPWLADHRVMDTVLFPGTGFVELARHAGEQVGCPALDELVLRAPLALPEIGGVAIRVAVGEPDETGHRAVRVFSCPDGEVDSVPSWTLHAEGVVAQAGTAPDFDLISWPPAGATAVDIDGVYDALDALGYRYGPAFRALTAVWRGDGGIYAEVAVPESVHADATGFGLHPALLDAALHAVRSASEMPTTEIALPFEWSGVTVYAGGADSLRVRLTPEGDHGVALDLADSTGIPVATIRHLASRPIDPARLTAGAATGRNALFEVGWTPVALPEVEATTARWAELGDDVPGLVVWDCPTGDEPGAVRAATHDALHVLQAWTTDSRFADSVLVVRTDGAVSVAGEAITNLAGAAVGGLVRSTQTEHPGRIVLLDTDSGVPDGVQAAGEPQIAVRAGQAYAGRLTRVTPAAAVPDDSFTADDTVLITGASGYLGGLIARHLVTARGVRRLLLLSRRGESAPGATTLRTELENLGARVDFAACDAADREALAAALSAVPAGHPVTGVFHLAGVLDDGAIGSLTPGRLDAVLRPKVDAALQLHDLTRDLPLKAFVLFGSVAATFGNAGQGNYAAANACLDALAAQRRASGRCGQSLAWGLWEAEGGMAAELDAAARQRIARSGVLPLAAEHGLALFDAAMRIDAATLVLARVDLDALRGAGTVPPLLADLVPQRRTAASGAAAALRARVAGTPDHERPAVLVEIVRGQVAAILGHDHAHAVDVDKAFNELGFDSVTAVEFRNVLKTVTGLPLPATLVFDYPTPQALAGHLVDMLTENDPSEPDTVPENEIRQALRTIPLSRLRTAGLLDTLLELAREGDTPRAATDDTGRGVADESIDELDIDDLIDLAYNGSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX00</accession>
    <name>A0A231GX00_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azoB_10</name>
        <name evidence="2" type="ORF">B7C42_06740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41144">
        <property type="protein sequence ID" value="OXR41144"/>
        <property type="gene ID" value="B7C42_06740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="29953" checksum="ACB1B8F5183F9542" modified="2017-10-25" version="1">MILVTGATGHIGRELVAELDRTGVAMRLFVRDPARAADLPSAAERVVGDLTDPAALRAACEGIDSLFLLVPGLAVEPARHAVVAARHAGIRHVVLVSSYNVLGDPMPAMGRWHHEREQIVGGSGMSATILRPGGFMTNALEWAPDIRAGRPVFDPTGPGRYSPIDPADIAAVAAIALTQPGHDTTYCLTGEQTFTIAEQVAVLADAIGRPIAVETATTAEEAVRSRYPQGAPPALAEAILEGFTLMRADTVGLRTDTVRRLLGRAPRTFADWCGRNRDRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX44</accession>
    <name>A0A231GX44_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain type dehydrogenase/reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41203">
        <property type="protein sequence ID" value="OXR41203"/>
        <property type="gene ID" value="B7C42_06601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="29525" checksum="77580434F78B025C" modified="2017-10-25" version="1">MGALEGRVAVITGAGRGIGREHALLFAREGAAVVVNDLGGSNSGDGTDAGPAQDVANEIVAAGGRAVANTDNIATWAGAEALVAQAIAEFGGLDIVVNNAGILRDGFIPGLSESDWDAVVAVHLKGHFAVIHHASAYWKAESKAGRQPNAAIINTASASGVTMPNAGQANYGAAKAAIAALTLVAADELQRYGVRANAIAPIARTRLTLATPGMGALMAAEAEDAAAEGGFDAFSPANISPLVAYLAAEKCPITGKVFAVQGGAISELAGWHDVKTIETDAAWTIDDIAARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX68</accession>
    <name>A0A231GX68_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41165">
        <property type="protein sequence ID" value="OXR41165"/>
        <property type="gene ID" value="B7C42_06761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="35"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="33050" checksum="7707389C2FD5039B" modified="2017-10-25" version="1">MTTYRQVDFASGGTTCDAWFFEGAAESPFDGPEGRPVVVMAHGFGGTKDSGLEPFAQRLAAAGLAVFAFDYRGFGASAGEPRQRVSMAAQAEDYRAALSAAARQPGVDPNRLVAWGISLSGGHALTVSADRSDICAVVALVPLVNGLAAGRVAFAQVGAAAIAKSTVSSVRSALAGRFGGNRVMMPLVGRPGEHAALTADGYYESYTALAGPTWRNEVDAAIGLELGNYRADRRAARITAPVLMQIADFDRAAPAHAAAKAAFAARAEVRHYPCDHFDIFAGNDWFEPAVDHQVHFLTRHLAAQRATTQEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXP9</accession>
    <name>A0A231GXP9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41397">
        <property type="protein sequence ID" value="OXR41397"/>
        <property type="gene ID" value="B7C42_06540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="20484" checksum="BC8FE2EE8F4F59B5" modified="2017-10-25" version="1">MQRPVALVAFLPGTGQHSGHYHRLGRGLGARGVEVWCLDTAGQGLSEGDPEAPGTLPELAGDAAALVRVLRAERPDPPLFLAGHSLGAATCLASMSLPEMSGCAGMVLTGTPKRAVESPAALPPGLPILALHGVDDRRAPIDAARAWSARHPSVGLHEYTDAGHDLLHEPVHAAVTADIAEWIREVADRRHGAAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXY9</accession>
    <name>A0A231GXY9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EPPG:FO PEP transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cofD</name>
        <name evidence="3" type="synonym">fbiA</name>
        <name evidence="4" type="ORF">B7C42_06591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="2.7.8.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CofD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41448">
        <property type="protein sequence ID" value="OXR41448"/>
        <property type="gene ID" value="B7C42_06591"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>7,8-didemethyl-8-hydroxy-5-deazariboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="382" mass="41113" checksum="54551E88AD958E7D" modified="2017-10-25" version="1">MVKLPTQFRYYPRPPSARFGNLEVANDQQIRTRTPASGHRIGCADVTGEQADIAAEIERIDRKPRIAVLVGGVGGARFLQGVRELLPEADVTALVNVGDDVWMHGLRICPDLDTCMYTLGGGIDTERGWGRVGETWHAKEELAKYHAQPDWFGLGDRDIATHLVRSEMLRAGYPLSAVTEALCNRWQPGVKLLPATDDRCETHVVITDPDSPGERRAIHFQEWWVRYRANVETHGFVTIGADQAKPAPGVTEIIEGADVVLLAPSNPVVSIGAILAVPGIRGALRTTSAKVVGLSPVIGGKPLRGMADECLEVIGVETSAEAIGRHFGARSDTGILDGWLIHSTDEADVPGVQVRSVPLLMTDPAATAAMVREALDIAGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY01</accession>
    <name>A0A231GY01_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41411">
        <property type="protein sequence ID" value="OXR41411"/>
        <property type="gene ID" value="B7C42_06554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15576" checksum="657BA18BED674FA2" modified="2017-10-25" version="1">MTQRPTLDDPVARTTAQRVVADFAAELQRAGETGDADLYDHSFAADVLWGSPFGATVVGYDQLNPIHHRLMAGQVAPPSTFEVVAATTPAPGVVVAQIRRRAADPAGFSETAMYVLVERDGRWWLAAAQNTPFEPEKSALRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY03</accession>
    <name>A0A231GY03_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41497">
        <property type="protein sequence ID" value="OXR41497"/>
        <property type="gene ID" value="B7C42_06389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="33900" checksum="0179C81356F5887C" modified="2017-10-25" version="1">MRIRSIVSLTAIAAVLVFGIVYMTVGVLHLDPRTSFLTADLRLPESGGLGPNSPVLFDGVAVGKAETVRKQASGVLVRLRIDDKYHIPATSDIHIEQLSALGEPYIEFASTSPGGPYLRDGQTISTERVHLPMTITALSTRAVALLEQIHPETVARLVDTFDTALTGTDQAMRTLQHSSDLLAATLLSRTDAIRQLFADMQAVGGNMDWLGPSLETAGPQLGRFGTMLIKIVEGGSVLSNKQPVDNYYTGDGLVPFLGQLNELLNKIGPAVAPLGPAVQPVLTEAAHSSPRIDVSALISQALQGVDPDGTLHFRIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY87</accession>
    <name>A0A231GY87_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780889.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41556">
        <property type="protein sequence ID" value="OXR41556"/>
        <property type="gene ID" value="B7C42_06449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011304649" evidence="1">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11159" checksum="7E55625449E5EA48" modified="2017-10-25" version="1">MPTIASTNGRFFVITDCVPQVRAAATAAAAGGTLAALTTATAAEITFPEGAFTDVAACATPQDGPTAWFATFNGGVPDGCVYAIDLTTGKVCTDNANRAAAWTRFVLAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ2</accession>
    <name>A0A231GYJ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783608.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41591">
        <property type="protein sequence ID" value="OXR41591"/>
        <property type="gene ID" value="B7C42_06232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21658" checksum="A576D57887AC168E" modified="2017-10-25" version="1">MGKGQNRAPRADATRNRDQLLAVATRVFASADSESSMRAIAREAGVGIATLYRHFPTRESLVDAVYRDQVIRLTAGARELLGRLAPAAALRRWMDLFGEWIATKNGMLDTLLTMIESGEIAHARTRTELLTAITEILDAGRAAGDIRTDVTAEDLAAHLIGIFTVAPRPEHEAKAARMLDILMDGLRPPTYGRPQVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYQ7</accession>
    <name>A0A231GYQ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41715">
        <property type="protein sequence ID" value="OXR41715"/>
        <property type="gene ID" value="B7C42_06057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="424" mass="47186" checksum="673A665BBA9471BA" modified="2017-10-25" version="1">MQGWYRVRVRGHRPVRQQALNCCRQSAQTLDGHGGLVEHLRQGGGNRFRGGHRTGGALNQVETGSLYQYDSCGNRSSGQGAHIGVDHGCQTGGTVGRPRDTHFVDDQLPQIVERRLVRRGEGVVGAREVLVELLRSDVRAAANVVDRRRGESPLGDRRHRGTQDAGPRIVLLRSSCPRREHPLVRIRRGEADRQGLPGRRQFDSLATDDRIAHGGIGFHHVGHGEYAQVVFFLPARHDTPLHHRHSRPRRPDLGTSVRIGIHCGVHEHPGAVLTCQGPHEVLQSAGRRPRAGHIADDDQELGHPVVDRHRCTLVLLHQVESFRSGAMAGQCGEVSARPARRRHHDRHTLFDRLGCDAAESLCARRHHDHGSRANVRSDLSAIPRVRQHLDRIRGTDDLRQFGVGRPDVVFETPDHQPDIMAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ28</accession>
    <name>A0A231GZ28_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxalate decarboxylase OxdC</fullName>
            <ecNumber evidence="3">4.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oxdC</name>
        <name evidence="3" type="ORF">B7C42_06211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41869">
        <property type="protein sequence ID" value="OXR41869"/>
        <property type="gene ID" value="B7C42_06211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046564">
        <property type="term" value="F:oxalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012149935" evidence="1">
        <location>
            <begin position="42"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="2">
        <location>
            <begin position="62"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="24310" checksum="C34CE73669C441A7" modified="2017-10-25" version="1">MSSDDPQESPTVNRRAALGTGAAALGGAALGAGLTTAAACAQTTPTALPSASDLDANLNTSPHLFHLTAADISRYNGGTLQGAHEQNFPVLAGQNGAAYFVRLDPGGIREPHWHPTAWELNYHISGTAKWTLLGTHPDGSYHTDVFEAHAGDLVFAPQGFFHYFENARTDAPLELLIVFNTSAPEMSDDIGLLGALNSIPREVTATVLGVPLSALADIPTDIKPIVITKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZR7</accession>
    <name>A0A231GZR7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH oxidase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42127">
        <property type="protein sequence ID" value="OXR42127"/>
        <property type="gene ID" value="B7C42_05726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="430" mass="45914" checksum="8C556432A3126C0F" modified="2017-10-25" version="1">MPSASTRDTLFSPVELRSGQILRNRIAKAAMEEGLAGKAQLPDRRLIALYRRWGAGGAGLLITGNVMVHAEALTGPGGIVLDADSPLEPFAAWARAGKAAGAAMWMQISHPGRQVQANMPGVVWGPSEIAVDVGRHSKRFGRPVAMTAEQIHETVTRFATTAERAERAGFDGVEIHAAHGYLLSQFLSPLVNDRSDEWGGSLANRARILLDIVRAVRSVVSPEFAVAVKLNSADFQRGGFDADDAHTVIGMLAGLGVDLVEVSGGSYESPAMSGRPTDGRTAAREAYFLELAAELAETSPIPLMLTGGITRIDTAERVLAKNVAVVGLGTALAVTPDLPDRWRDGLGAAGALKPVTWSDKPLAALAQMAQVRYQMRRMAAGKDPALGIRPALALLADQREKSRALRRYSRWLASTRRERAASPASRVTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H001</accession>
    <name>A0A231H001_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypE</name>
        <name evidence="4" type="ORF">B7C42_05779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42180">
        <property type="protein sequence ID" value="OXR42180"/>
        <property type="gene ID" value="B7C42_05779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="64"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="187"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="361" mass="36448" checksum="CDC7674A54F2B208" modified="2017-10-25" version="1">MLDHAETSTPPPVFDAESWVCPLPLRDSPTIVMAHGGGGAMSGELIEHLFLPAFGAAADAALGDAAVVEVGGTRLAFSTDSFVVKPLVFPGGTIGELAVNGTVNDLAMAGAQPLVLSTAFILEEGTDLAEIARVAEAMGEAAGTAGVKLVTGDTKVVDAGHGDGIFVNTAGIGLVPAGVDIRPERARPGDVVLVSGDIGVHGVAVMSCREGLEFGTTVRSDTAALNGLVAAVLATGADVHTLRDPTRGGVAATLNEIAKAANTGVRLDERALPIPDAVRDACGLLGLDPLYVANEGKAIAFVAAQDADRALDAMRAHPLGARACAIGVCVDEHPGMVVARTALGGTRVVDLPAGEQLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H067</accession>
    <name>A0A231H067_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42256">
        <property type="protein sequence ID" value="OXR42256"/>
        <property type="gene ID" value="B7C42_05455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="20351" checksum="1066800785529455" modified="2017-10-25" version="1">MSATATAQVIHGLTGLAAEDILFERCWPLIAQVLLRQGFSWSALNDLAAMDFRDDSVIETKLGKLHGQIDRHLGGAPRLDPWDVVAGTYGRAWRMDLIGPISAMWRIDNLWWRIRKLDRKDRGGLLVIWAGMGVKEQDDGTSPLQAIDDLAVDVLSEADLLLPPGAVDYELCKAVREALDANGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0V9</accession>
    <name>A0A231H0V9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">accC_1</name>
        <name evidence="12" type="ORF">B7C42_05248</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42472">
        <property type="protein sequence ID" value="OXR42472"/>
        <property type="gene ID" value="B7C42_05248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="118"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="10">
        <location>
            <begin position="559"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="820"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR42472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1057" mass="111301" checksum="6F81573FF8DB4570" modified="2017-10-25" version="1">MQVVVANRGEVAVRVLRTARERGYGTRALSTADEPDAMPVRLADEAVRLPGSGAAAYLDIDAVVAAAGSAVPGALVHPGYGFLSESAVFASACAAAGLVFVGPAPEVLRIFGDKVAARRAAEQAGVAVLPATSGAAGPEQIEALLAAHPEGVMIKATAGGGGRGMRVVRRREELAQAYAHCRAEARAGFGDDAVYAEALVEHARHIEVQIVADGSRAVAVGDRDCSVQRRRQKLIEIAPAPSLAPDLRERLHTEAIRLAETVGCRGVITVEFLVRDDTAWFLEVNPRLQVEHTVTEEVTGLDLVAAQFDLAQGRGLDDLELPATTRGYAVQVRVNAEILSATGDVLPSTGVLTRFTPPTGSGVRVDTAAYSGMRQGAGFDSLLAKIIARGPTCPAALRRAADALAETTIDGVDTTVALQRAVLDALPGDTTVDTLWFERHSAELAARAEESAPPPSPPVEAAPTAVDRYDGDEQVLRSPLGGTVISVVEPGTVVAAGAEVAVVEAMKMHHVVRAGQPLRVVRVLAEPATVVDPHAALLVWDDADHDGEDADVTAVDLDAERDDLAQVRARHRAGLDETRPEAVAKRHRLGRRTARENIADLVDDDSFVEYGALAVAAQRSRRSIEDLIAKTPADGLVAGVATVNATRFGHDRARAVVMSYDYTVLAGTQGMRNHAKTDRMLELAREQRLPVVFFTEGGGGRPGDTDHAGISGLDVTTFRAMAALSGTVPLIGIVSGRCFAGNAALLGMCDVVIATPDANIGMGGPAMIEGGGLGVYAPEEIGPVRVQRRNGVVHIVAADEAEAVAIARDYLGYFQGDVDTWEEPDPRLARHVVPEDRLRAYDIRAAVAAIADTGSVLELRRDWGVGVVTALIRVQGRPFGLIANDCHHLGGAIDAPAADKLSAFLRLCDAHGLPIVSLCDTPGFMVGPEAETHATVTKFSRLFIDAAAMSVPWGTIILRKGYGLGAQAMAAGSFRAPRFVVAWPTGEIGGMGLEGAVRLGFAKELAAIEDPAQRSAAFDNLVRAAYESGKALTAATVLELDDVIDPAHTRRWIGTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Y8</accession>
    <name>A0A231H0Y8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42535">
        <property type="protein sequence ID" value="OXR42535"/>
        <property type="gene ID" value="B7C42_05311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="348" mass="35467" checksum="6D0936E0E47E3E20" modified="2017-10-25" version="1">MRTCRLRIRPALRRFAAEVDHVPAARVFAGLAIPGALLVAAGRWDLLVYAVFGSFTGMYGFAESARQRAAHQVQAAALLITGVGAGLACAHAHAPQWVLVPAVATFAAVVSPITDRAGLRPEGPFFALFAFGAVATVAGTHTDPLVALSICVATAALCVAVGYLDAVRRPGVAAVPVVRTGIDAFRHAARYAVAISVAGGIGLLLGFGHANWAMAGAAVPLAADSARGGVRRGAHRVVGTFAGLAITAPLLLPHLPPALPAVAIIALLYPTELFIARHYALALGFFTPLIMSMTELAAPGDPAALLRDRAVDTLVGVGVGVAVVVLLRNPAPRSAAGLASPAPAAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H153</accession>
    <name>A0A231H153_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42594">
        <property type="protein sequence ID" value="OXR42594"/>
        <property type="gene ID" value="B7C42_05371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="36031" checksum="CF161C1B2803A2AF" modified="2017-10-25" version="1">MTAARTARHQRISAFLASRSDTELAELVGAGRVISVGVGGGAALVDVDSVPVFTKRIPLTDRELADPGSTANLFDLPMYCQYGIGGPSFNAWRELAANVIVTDAVLAGETQSFPILYHWRVLPGRSPVAAEHADIDTVVTAQGGSPAVRARLEALAAAPCSLVLFCEYIHHPIAAWLRADPAGKAATVERQLSEIVMLLRDRELLHMDGHFGNMRTDTERIYLTDFGLGTSPKFDLSPAERDFAEQHTTHDAAYAAMRLVNWLVTDVCGVPTPPTGGPAARNEYVLRCAAGLIPDDVPPPVAAILAPHAPDAAKMNAFYWRLFDGDLHTKYPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H157</accession>
    <name>A0A231H157_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42589">
        <property type="protein sequence ID" value="OXR42589"/>
        <property type="gene ID" value="B7C42_05366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="22042" checksum="3DE372AA96BC6C48" modified="2017-10-25" version="1">MVRSVFHVGQDDPMAAPLLAELAIEYSSRYGGSVGEVHADLVNYPAADFAAPHGDLLVVVEDGEPVAGGAFRRYDEQTAELKRIWTAREHRRRGLATFVLAELEAEALRRGYRRIFLTTGPRQPEAVALYLSAGYTPLERTPSVQPGLLAHPFEKYPTRVAKVQRRNRFGRERDGVYTPVRSGFRYPPVRGEAGAVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H165</accession>
    <name>A0A231H165_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadK_5</name>
        <name evidence="3" type="ORF">B7C42_05376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42599">
        <property type="protein sequence ID" value="OXR42599"/>
        <property type="gene ID" value="B7C42_05376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="448"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="541" mass="58161" checksum="314304E5D32AEC4D" modified="2017-10-25" version="1">MGNRAADSIVPGSFATAPEPYADHSIGDIVQIWAQQIPHRTAFVTAAGSTSWREYDRWADTIRDGVRATPGGPRSRVALLLPDTAAVHAALCGCSRAGRIAAAVGARSGVREIAHVMRRTDASTLITVPEIRGRTWQTLVRELEAEGVTPGHVLVVDEQSRTLAHHRIGARQAHENAAAGASFTPSDVSVLNSTSGTTGTPKIVAHTERRWTAFARAAMLGARIGPRDVICSVVPAPYGFGLWSAHFLPALLGIPVVVTARFDAEETAMLIERERVTILCCVSTQFKMLLRSGALERHDLSSLRVLYTGGEPVPYRDARAFEERTGAKVLQFYGSNESGAVSGTTLDDDTDTRLRTSGRTLPMMNVRVLDEAGADVDGEVRRGRPAVRGPLVSAGYWDDPAADAELYTPDGWTLLGDIVEIDETERVRVVGRTSDFVIRGGKNISITEIEELVREHESVTDVAVVGVPDDVYGERVCAVVVLADGATLDAAGLSGRLESRGVTKEYTPEYVVVVDRLRLGPGGKTDRGAAREAAMRTLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1M2</accession>
    <name>A0A231H1M2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator VirS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">virS_2</name>
        <name evidence="5" type="ORF">B7C42_05078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42741">
        <property type="protein sequence ID" value="OXR42741"/>
        <property type="gene ID" value="B7C42_05078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="254"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="355" mass="38551" checksum="ED0083524CE4183D" modified="2017-10-25" version="1">MLVRSPAFLTLRDKYLILDDMSVIRSAGLRGFRATVAELGGNAEEYATAAGYPIAALDADDLLVSDEAMALVLEIAADRLRCPDLGLRIAARQDLGMLGPLALAIRSSPTLADALECTSRYLFVHARSLSLTIEPDPYGDRGVTALRYGVEPGFPQPVQGTDLGLGFLHRTLIRLVEGPYGLRSVELPYRPPGSRATYENFFGVPVRFERPAAMLRLPSNLTTRAIAGGDANLRRLAVAFLAEQAGDTGASTVPGVRAAVQQLLGTTAPQIDSVARLLTIHPRTLQRRLAAERTTFAAIVDDVRRSEARRYLTTTDLPMSQIASLLGLAEQATLTRCARRWWDSTPTAIRRTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H231</accession>
    <name>A0A231H231_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42899">
        <property type="protein sequence ID" value="OXR42899"/>
        <property type="gene ID" value="B7C42_04785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="159"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="31037" checksum="972CB7D3F0A7436C" modified="2017-10-25" version="1">MLHGWPGGVLSVSTALLRDTGRVSAIVDVVHALVDEVRTESSSREIAVGASALGTAALLASALAGRVGDSSVSGVRIGWSALRALVVSALFVVVAVQVAESGWITGADTATLRWFVEQRNGTATAWARAITEIGSPIGVAASAVVVSGMLAWRRRSAAPAVFVLGTVGFAAGVGTLTKLVVARSRPPAVLHLMAESDFSFPSGHITATTALVAAVLVVSMSTRPGFVRTAAATVSAVVIVAVVAATRLYLGVHWLTDVVGGAMLGTAVTLASATVLLWISRSAGDGRWRSGSGPAVVASVPAGNRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H235</accession>
    <name>A0A231H235_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-6Y C(5,15)-methyltransferase [decarboxylating]</fullName>
            <ecNumber evidence="8">2.1.1.132</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cobL</name>
        <name evidence="8" type="ORF">B7C42_04796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.132" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42910">
        <property type="protein sequence ID" value="OXR42910"/>
        <property type="gene ID" value="B7C42_04796"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046025">
        <property type="term" value="F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="425" mass="44997" checksum="556128443EC92A29" modified="2017-10-25" version="1">MTDEQSSLATEYSQDTPNNDRVIAVVGIGADGWPGLSPRVRAEIASAEVLFGSRRQLDLVPADASTANRRAWPTPLLPALPELLSAHRDSRICVLASGDPMFYGIGVTLAKLLGPQAIRVYPQPSSATLACARLGWPSAHTPVVSVVGRPLETVLPELGDGRRLLVLSADEQSPAQVAELLRRNGFGESRLTVLEQLGGPGERIVAATAAQWSRPPGDPLNIVAVEAVRDPAAPRFTRLPGLPDASYGGDGQLTKAEIRTLSVAALAPAPGELLWDVGGGSGTIAIEWCRTHSDCRAITFERSATRREQIADNAAALGVPVIIVRGEAPADLPAAGDPAPDAIFLGGGLTQDGLFEACWDRLRPGGRLVANAVTAESEALLLRWAAEHGGELRKFQVYRGEPLGGFTAWRPHLPVAQWIAVKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2C3</accession>
    <name>A0A231H2C3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42977">
        <property type="protein sequence ID" value="OXR42977"/>
        <property type="gene ID" value="B7C42_04863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="7355" checksum="99F1C05039B416FC" modified="2017-10-25" version="1">MSVDLSGATWFKSSRSTATRECVEVAFLEGGAVGVRDSKNPGGPTLVFTPAEWDAFTGTMLNGGFSQPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2X1</accession>
    <name>A0A231H2X1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetracycline repressor protein class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tetR_11</name>
        <name evidence="6" type="ORF">B7C42_04608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43186">
        <property type="protein sequence ID" value="OXR43186"/>
        <property type="gene ID" value="B7C42_04608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="22798" checksum="82F11D1FE2A19774" modified="2017-10-25" version="1">MARQRGGTQPVPLSAQDILEAALRIVQRCGLDRLTVRAVADELGVTPPAVHYHLRGGEDLDARVIEAVASRIEIAVDPEAHWVDQYAGLVSSMDRAFLRYPGTGTRVLTAARESPAAERLTGAALSILRTAGLGEADAVDLFTATYLMFAGWLATRGLRETGGTHPALIAAGVTAPDLADGTALDRALRRLLENAAAARSGTGNERDNPRDGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H341</accession>
    <name>A0A231H341_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent hydroxymycolic acid dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd2_6</name>
        <name evidence="2" type="ORF">B7C42_04638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43216">
        <property type="protein sequence ID" value="OXR43216"/>
        <property type="gene ID" value="B7C42_04638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022378">
        <property type="entry name" value="F420_OxRdatse_MSMEG2249_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03857">
        <property type="entry name" value="F420_MSMEG_2249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="350" mass="36502" checksum="0C789C45E2D178EA" modified="2017-10-25" version="1">MGMSEQKSSAAERAGRLGAYVVPGRVTDPRPALTQAAEAERLGLGTVWLSERWGAKDFGVLFGAISQVTSDIDIAAGVTHLNSRHPALLASMAMTAQALSDGRLVLGVGRSVAAMWQSVGLPVPTNRSLTDSADIFRRLCRGEKVRYQGPAGNFPALRLTDVPDQPVPPLLLAAIGPRGLELAGRHFDGVILHPFLTPEAVARSAQLVRAAAAAAGRPADAVRICATVVTASGLAPAEEAAIVAGRAVSYYQIPGFGEQLARVNDWDPDQLAVLRAHPQLAGIRGSADSVRTAAQLVEAAAALPARWLNEASAVGTAAQCHAVFDRYLDAGADELILHGSTPDRLASVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3K2</accession>
    <name>A0A231H3K2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43430">
        <property type="protein sequence ID" value="OXR43430"/>
        <property type="gene ID" value="B7C42_04297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="211"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="31371" checksum="58DEE8B5CDBA9404" modified="2017-10-25" version="1">MNTAADGGYAPAMTASIEQLLHTLTKVVNALLAHEIDFAVGGGCAVYARGGPASDHDVDIYVKPADAFRARDILTASGLHAVDPPEDWLTKVYDGNTLVDLIFRPNYRNVDDDLLGRATWMRIGPAAAPVLSGTDLMVDKLMVLDPHRLDFTRLLAIARDLREQVDWRRARDETAVSPYARAFLALIEDLGIGGEVMAQDSGDEVLPQYLVANLRRAFAEDPRTAELGVQVTIRGTVVVLCGEVGSEQQRSDLEDIVREHAPKLRIHNDIRVTSTQSPIVDHERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4C1</accession>
    <name>A0A231H4C1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502645.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43556">
        <property type="protein sequence ID" value="OXR43556"/>
        <property type="gene ID" value="B7C42_04424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="18747" checksum="8F3A3B63610A94AB" modified="2017-10-25" version="1">MERTLWVIGLAVLFVLFLWLMYRSWLVRARKQASSVGELPTVPADLGAQVLEPTTGLYTGTTLAPSWQNRIVVGDLGFRATAELTRFERGILLERDGAEVIWIPQESITAVRTERGHAGKVMTDNGVLVIRWKLPTGTEVDTGFRGDDKTVYPAWTAISATGQTGAATGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4F5</accession>
    <name>A0A231H4F5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43672">
        <property type="protein sequence ID" value="OXR43672"/>
        <property type="gene ID" value="B7C42_04540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="40" mass="4366" checksum="7A71C7E7EBC7C25A" modified="2017-10-25" version="1">MRIATRFPGERTPATGGADRIAHIRGVVVKIGSAWRARHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4K6</accession>
    <name>A0A231H4K6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GMC-type oxidoreductase</fullName>
            <ecNumber evidence="4">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43722">
        <property type="protein sequence ID" value="OXR43722"/>
        <property type="gene ID" value="B7C42_03957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="543" mass="59643" checksum="FE7706B442CB2250" modified="2017-10-25" version="1">MPDRESFDYIIIGAGSAGCVLAQRLTEDPQVSVLLLEAGPEDRADEIKIPAAWGKLIRTQWDWRYETTPQKHLGGQRAYWPRMKALGGCSSMNAMIFIRGNRADYDGWRRDFGAVGWSYEDVLPYFVRSETNTGLRSPYHGTDGPLHVENRRFTHELTDAWIAAAAAAGLPRTDDFNGATQEGVGRYQVTHRNGRRWSTADGYLRPALDRPNLTVRTEAHATALVLDGARAVGVTYRRHGSEHTVRAEAEVLLSGGAINSPQLLMLSGIGPAAHLRELGIEVVVDLPGVGENLHDHPVTPILWRTRGVSDLADFETPFRLAQWQALGRGPLTSNVGEGGGFVRTREGLEGPDIQYHVAPTAFYDNGFHENIAPMFTAGPTLVDVHSRGRLRLRSADPLWKPEIDPAYFSDPRDADALLAGCRQLLEIARQQPLAAHLDRSYLPEDADRIDEDGWRAHIARWTQTLFHPVGTCAMGTGETAVVDPELRVHGVSGLRVIDASVMPRIVRGNTNAPTVMIGEKAADLIRGRTPSSSTGTATKEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Q1</accession>
    <name>A0A231H4Q1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43841">
        <property type="protein sequence ID" value="OXR43841"/>
        <property type="gene ID" value="B7C42_04076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="20584" checksum="9E6EDBFDBC0495AB" modified="2017-10-25" version="1">MATPHFDLESATDAMTEIVSGIGADDLSAATPSPGVSVRDLLFHTLGFTEGFRQGATKEGVGRSAPPRQAPDADLPEGWGELITTQLKALTEAWRDPAAWEGDTEVGGVTAPAPAMAGFALNEVVMHSWDLACATGRRFEPADKDVAVLLEQFRETPREGVPGLFGPVIEVPADASDWERLLGLTGRDPYRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4U6</accession>
    <name>A0A231H4U6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43884">
        <property type="protein sequence ID" value="OXR43884"/>
        <property type="gene ID" value="B7C42_04123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="25526" checksum="A8AE3563F7CE585F" modified="2017-10-25" version="1">MFDPLADIDRALADRAGWTWFDDHLLYTCGVLDLLRREELAHMPVKSTRIRIDPGEVCIAEGPATWSFWRSPGNGSWTRNNIYVAGSASFVAAAQLGNALVNQARRQRAEAASQPRWIAERPGSVMISDRRIHLTNPDYSFRIRWASLETIDLTAADHVVARYVDRNHTFHQWQVRTPWAVLVFVVAAHLHFPNHPLLLSGNWLPAGFEDKCHLAGKTCPPVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5J9</accession>
    <name>A0A231H5J9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44052">
        <property type="protein sequence ID" value="OXR44052"/>
        <property type="gene ID" value="B7C42_03608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="22427" checksum="508C8DEC808A58DC" modified="2017-10-25" version="1">MGDLLVLLLPEVIGLIVTPGAVAGCVLLLQSRRPIANASAFGAAFLLVYAQIAVAALLGGAGDPQSTSKQTSHWAGLVVGVLFLVAGAVIAVRKPKTAPGGGPRWMTQLENTGPRGAFIAGLALAVVNPNLFIMLSGMSLIASSATSVAASAVGTIVLLVAAVLDFLVPIGIYLLLGERARTGLDAAKVWMIRHTRLLSIGVLLVFGALFTIRGIVNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5M6</accession>
    <name>A0A231H5M6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase EstD</fullName>
            <ecNumber evidence="3">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">estD</name>
        <name evidence="3" type="ORF">B7C42_03720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44161">
        <property type="protein sequence ID" value="OXR44161"/>
        <property type="gene ID" value="B7C42_03720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624276" evidence="1">
        <location>
            <begin position="23"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="193"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="458" mass="48717" checksum="A7B870D34371574C" modified="2017-10-25" version="1">MVATLLAVALVAACSSSDTVTATPRPAPVTGEWNGVLPLPNQQLPVGVTFTEDGGSVTVPAQGIFDLPLEQVDIAPDAIAFTIPGLPGDPHFNGRYDRRADVVTGTFTQSGHDLALTLHRGKVPAPLRPQEPRPPWPYLSEDVGYRSSDGTHIAGTLTRPRGPGPYPAVVLVSGSGPQDRNEEIAGHKPFLLLADTLTRAGYAVLRTDDRGVGGTGGQLDTSSYTDLTDDIMAGLGYLRSRPDIDGNHIGLLGHSEGGYLAPLAATRPDSRLAFVIMMAGPAVSGSEVLLAQNQLLLRGEHADADAIRKQVGYITTLTTLIRTGDDEQVRRFATEHNDSLPPEQRQSQSALDQLTTPYFQALVDYDPAPALQALRIPVLAFYGTKDVQVPAAQSAPAARANLAGNPNADVHVFDGLNHLMQPADTGSPKEYPTIETTIAPEVLNYITTWLGKYVTPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Q2</accession>
    <name>A0A231H5Q2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_6</name>
        <name evidence="4" type="ORF">B7C42_03751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777490.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44191">
        <property type="protein sequence ID" value="OXR44191"/>
        <property type="gene ID" value="B7C42_03751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="414" mass="45861" checksum="9F619E3C2EB22789" modified="2017-10-25" version="1">MSRYLHFTVNLIPGPLQASDGSHPFIDIDDFVRSAQLAEQVRLDSVFFADSQGIGPDGRSFAYLDPLVTLPALARETERIGLVATVSTTYTTPYALARAILSLDHISHGRAGWNIITTMEPTVARNFGLTQPPPRAERYRRAQEFAEVVEKLWVSWDDDVTATWDLRKLRRAPIDHHGEFFSVAGPLQLPRSRQGKPVIFQAGGSDDGIDTAARFADAVFSVGVDEDASRTYRERLNKEARSRRGDSAGVLVLPGIFLTVGSTDAEVQRLLHEAEQALEESETVHRFLSRFDLDPEAVNLDGPVPPEVAVTDSTRSIGFAQGGVDLARRHPDLTLRRFIVLGGGGHRRIFGTPESITDELIGWAERGAADGFTVFVESLPQFAEHIVPRLWERGVHRREYTGTTLRDHFGQTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5R5</accession>
    <name>A0A231H5R5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxC_2</name>
        <name evidence="7" type="ORF">B7C42_03795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514619.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44234">
        <property type="protein sequence ID" value="OXR44234"/>
        <property type="gene ID" value="B7C42_03795"/>
    </dbReference>
    <dbReference type="GeneID" id="66721541"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="13070" checksum="C68522B6AA046C5E" modified="2017-10-25" version="1">MATQTLTAQNFDEIVTGNDVVLVDFWADWCGPCKAFAPTFEASSEQHPDVVHGKVDTEAEQSLAAAANIRSIPTIMAFREGVLVFAQPGALPPAALEDLVSQVKALDMEEVRKQLAEQQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5T0</accession>
    <name>A0A231H5T0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hemin transport system permease protein HmuU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hmuU_1</name>
        <name evidence="9" type="ORF">B7C42_03740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44180">
        <property type="protein sequence ID" value="OXR44180"/>
        <property type="gene ID" value="B7C42_03740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012963454" evidence="8">
        <location>
            <begin position="29"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="34294" checksum="C9BAAC5215DB4202" modified="2017-10-25" version="1">MNRVRTTIVVPVTLTSLLVAMVVATACGAEPLPIRAVLEVLGGHLGGSGAVDSAFDTIVWQLRVPRTILAAVVGAGLALAGAAMQTLVRNPLADPYLLGVSSGAGVGAAAVITSGLFAGAGIWALSGGALAGALIAAATVFAIAMAQGGLTPLRLVLTGTVLGSAFSALSSYLIFRSADPKAAQSVLFWLLGSLAGADWTRIAVPATVVGFAGAALFAVHGWLDALSVGADTAASVGVPVRAVRYGLFTGLAILVGVLVAVSGGIGFVGLVVPHAARMLVGSTHRRLLPVAALCGALFLVVADAAARVLVRPTEIPVGVLTGLIGAPVFLLLMGRRRYRFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5X0</accession>
    <name>A0A231H5X0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thpR</name>
        <name evidence="1" type="ORF">B7C42_03796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777545.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44235">
        <property type="protein sequence ID" value="OXR44235"/>
        <property type="gene ID" value="B7C42_03796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="173" mass="19173" checksum="1847029E41914962" modified="2017-10-25" version="1">MVQSVELVLDEAAEAEIRRQWRMLAEAGMHSPTPPHRPHISAAVAREIWPRLDRTLAALPFEPLPIRLGGLLIFGARHPILVRLVVPTEDLLTMQRRIAAVVDACPGVPANMCPDAWTPHVTLARRVRPEHWPAAIDAVAAERDFAATVVGIRRWDGDRRIEWPIAPGGGDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7W6</accession>
    <name>A0A231H7W6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44935">
        <property type="protein sequence ID" value="OXR44935"/>
        <property type="gene ID" value="B7C42_02892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="23606" checksum="F90180C36A3EF8C8" modified="2017-10-25" version="1">MKLDVASSEAVLSTVVTDVEVTGRRANKRGIQSREAMLEAAITSLATGDPAAVSGNRIARDIGATWGVVKYQFGDIDGLWAAVLRYTADKRGDLPAGIATEGTLAERVSALINTMAIGLRRPESLAIETLRAALPRDHAELERDYPLTAAELASWKPNWDKACERAFADLGVDPVKIRRVAALIPAAMRGITSERTLGTYGNLDDAIQGLIDGMVAYLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8C7</accession>
    <name>A0A231H8C7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator MgrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mgrA</name>
        <name evidence="2" type="ORF">B7C42_03017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778761.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45060">
        <property type="protein sequence ID" value="OXR45060"/>
        <property type="gene ID" value="B7C42_03017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16931" checksum="1E5C4B8C54A33596" modified="2017-10-25" version="1">MTDDDFQTAFWSTKHALAVAAAAAYARHGVYEGQQFILRQLWQEDGLTPGQVAKRLGLATPTVTRATTRMEAAGLIRREPHPTDRRLVRLHLTARGRDLEHEIEAESARLTERALTSFSSAERAALFRALRRIEANLTESAPAEANPRGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8D8</accession>
    <name>A0A231H8D8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F420H(2)-dependent quinone reductase</fullName>
            <ecNumber evidence="3">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44996">
        <property type="protein sequence ID" value="OXR44996"/>
        <property type="gene ID" value="B7C42_02953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18682" checksum="0A70A76CF2712270" modified="2017-10-25" version="1">MSDRARRSRIGNPLSALGRAIARIPWVMRTGPVVVVLERVIRRLTGGRHGVLDLAGLPSMELTVRGRKSGLPRTVSLLYVPDGPERYLLIGSNWGRPEHPSWSANLAAASDAEIHSGGRRIKVRVRHLSGAEREDAWARAVAYWPGYTMEQRLAGERRFRLFELTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8F7</accession>
    <name>A0A231H8F7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3 beta-hydroxysteroid dehydrogenase/Delta 5--&gt;4-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45072">
        <property type="protein sequence ID" value="OXR45072"/>
        <property type="gene ID" value="B7C42_03029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="37031" checksum="02EE2752BAA15167" modified="2017-10-25" version="1">MKALVTGASGFLGGALARRLVREGGHEVTVLARRTSNLGDLPGLDGVRVAFGDLTDTPSLESACAGVDVVFHSAARVDERGTRAQFRAENLRATEVLLRAARAAGATRFVFISSPSALMDRDGGDQIDIDESVPYPRHYLNLYSETKAAAERAVLAADTAGFTTCALRPRAIWGAGDRSGPIVRLLGRTAQGRLPDLSFGRSVQASLCHVDNIVHACLGAATSDRVGGRAYFVADAEKTDVWAFLAEVAGGLGYPAPSRRPDPRVLAAAVSVIDTVWRVPAIARRWSPPLSRYVVALLTRTATYDTGAAARDFGYAPIIDREQGLARFLSWLESEGGIEQLTRELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8M6</accession>
    <name>A0A231H8M6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45205">
        <property type="protein sequence ID" value="OXR45205"/>
        <property type="gene ID" value="B7C42_02330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012917944" evidence="2">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="29919" checksum="DDAD89477A66668C" modified="2017-10-25" version="1">MSTRTTRLGLVAGIRVVAALVVVGSAVAVTALTVHQNDQVTSVVVHQEAASARAAASSDAPAAPAPAAKPPAPGAPAGPGPAAAPAAAVPLGGATAPAPGVGPANSGAPNRSTPLGPSASGPNAAAPGANGSVPLAGNPFAAPAVNTQPRCPLGWPAPGPDQQGGLASLIGLAPLAGPFSSEAFALGSVYQPLLQLAGPVLSQIAPVIAHYQPVIDPFITQVQGAEAVVLQAILPYYGPYRDQLIAAEGDLARQLAPVLDQAYNSELASCFVAWQGQIIDQAKGGPIHVASLAHPGTVVELGPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8S1</accession>
    <name>A0A231H8S1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776748.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45265">
        <property type="protein sequence ID" value="OXR45265"/>
        <property type="gene ID" value="B7C42_02390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="151" mass="16741" checksum="B4C6ED5920F785F8" modified="2017-10-25" version="1">MADSPDVRIGTAEREQAMQRLSEHFAAGRLSVAEFDERSGLIAAAVTRGDLAPVFSDLPAAVPEPPEPPEPAAAQPGGRREFAGPMMGLVVILALVLFFTTHTWLWFLLIPAAGIITGGLQQRGHDRRLLGGDDHRALDRRRRRRDRRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8S7</accession>
    <name>A0A231H8S7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_02383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45258">
        <property type="protein sequence ID" value="OXR45258"/>
        <property type="gene ID" value="B7C42_02383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="181" mass="20755" checksum="35A90262CCE3A2C3" modified="2017-10-25" version="1">MPFVDDVVNILPKTLRDLAIRHHELIKFAIVGATTFVIDSGIFYILKLTVLESKPITAKIISGVIAVIASYILNREWSFKGRGGREKHHEALLFFMVSAIGVLLSNLPLWVSRYFFHLHVPDVSLTVENIADFVSAFIIGNILQMVFRFWAMKRWVFPNEIDALVEEFEELYEEEKPLGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8T6</accession>
    <name>A0A231H8T6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776744.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45269">
        <property type="protein sequence ID" value="OXR45269"/>
        <property type="gene ID" value="B7C42_02394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="28878" checksum="3D80E928501EF179" modified="2017-10-25" version="1">MSDSWPRRRLLAILRGASEPLDAQELARITGQHVTTVRFHLDVLTRESLVRQFQQPPRGRGRPRIGYTAVQRSVGYQDLAQVLADQLGSDPRRRSELAVTAGRAWGAKVEQLEQPIASLDDARDIAVTVSSELGFAPERDPASETGDQLNIRLTACPLRELARTHSEVVCGVHQGLMREVLDRNGGRDAVNVRLHPFVGPELCVIHLEALASTLPDPAHIPDQAGAAPRLPTPSANRVGPQLRTDPQLRNTDAHVAQEATQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H927</accession>
    <name>A0A231H927_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein HscA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hscA_3</name>
        <name evidence="4" type="ORF">B7C42_02322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45197">
        <property type="protein sequence ID" value="OXR45197"/>
        <property type="gene ID" value="B7C42_02322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="37621" checksum="A51BCF488C76988F" modified="2017-10-25" version="1">MDAMVLVLGVSAGAGGARAMLTHSDQPHLPPIDRCVVARRAGAGVEEPVFQAIDAMRASAADRDEFVTGIAVTSRCALHAEAIRAAAGRSRLTIIDEPPAQLRYLRFSGQLPDEGAVLLYDLGSSGLTLTEADCHTQAILAAKRSTLLGGDGHDALLRWHLAHGGVEIDNVAGRVYKEQLSSTRVVTVGDPRSGTRIVVTRSDFRDLVAAGIHHSVSYVRQLIDDTGVAPRAVALLGGCTRSPGIRESLEQLLDLPVIYDPEPDFVSARGAVLMATEQPAARRVRGIRFAPPQCGSAAPTPRPAVSRRKVVAALAVTAALGATVTGLLVTGHDSARPAHDGTPARPVEVAGSSAEPVPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9H8</accession>
    <name>A0A231H9H8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkane 1-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.15.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alkB_1</name>
        <name evidence="10" type="ORF">B7C42_02633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.3" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45508">
        <property type="protein sequence ID" value="OXR45508"/>
        <property type="gene ID" value="B7C42_02633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018685">
        <property type="term" value="F:alkane 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052869">
        <property type="term" value="F:arachidonic acid omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03512">
        <property type="entry name" value="Alkane-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033885">
        <property type="entry name" value="AlkB/XylM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38674">
        <property type="entry name" value="PTHR38674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="117"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="384" mass="43461" checksum="3B5088FD39207324" modified="2017-10-25" version="1">MAIFEQSRARDPKRYLWMLGLIAPACALLPGPLVVLTGSPVFWWIGPIIVFVAIPLLDWTIGNDGSNPHDEDYEALSNDRYYRWCTYLFLPMQFFGLFIAGFLWADTALSFVDKLGLTVTLGVVSGIGINAAHELGHRSEHLERWLSKIALAQSAYGHFFVEHNRGHHARVATPEDPASARFGESLWVFLPRSMFGGLRSAFRLERDRLARRGKRWFSYENHLLQAWSMSVVLFGAMILYFGPRVIPWLALQALIGALLLETVNYVEHYGLLRARRADGTFGRCSPRDSWNSDSLVTNIFLFHLQRHSDHHANPGRRYQTLRSVDHAPQLPMGYAGMVLLAAVPPLWRAVIDPRVLAHYGGDRSLVNVKPPRKRPVEGVGDRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9H9</accession>
    <name>A0A231H9H9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbB</name>
        <name evidence="2" type="ORF">B7C42_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782484.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45673">
        <property type="protein sequence ID" value="OXR45673"/>
        <property type="gene ID" value="B7C42_01965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="34203" checksum="D152D57B90B1B2B6" modified="2017-10-25" version="1">MRIGVTGGSGFIGAHVIRRLAESGHTVYALDTVAPSTPDPRARFRRLDVLDPAAVLDASSDLEVIFHLAGMSNVDVAQHDPLRTVRLNVDGTAHVLEAVRVHGLRRMVFASTVWVYGAAYDTSGGTEPLTEAAPMALAKAGHIYTSTKIAAEMLIHSYAETYEVPFTILRYGVPYGPGMRDELVLARFVRKALAGEPLTIAGDGKQFRNYVFVEDLADAHALVLDDAAENQVIALEGNERVSVLDMAEAVQARFPGTTIEHVPARPGDFRGIDVSNALARTLVGWRPTTTFQDGVRRYVEWYLAEHPDSAAAPGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9K0</accession>
    <name>A0A231H9K0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45535">
        <property type="protein sequence ID" value="OXR45535"/>
        <property type="gene ID" value="B7C42_02660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012420939" evidence="1">
        <location>
            <begin position="32"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="16002" checksum="7820B64766EDB800" modified="2017-10-25" version="1">MIKIKSRAVAAFSLAAVVFAGGVASVTPAVAAPIAAPAHAAAPGVGELQSKLQLVLDPNGSRSARANELEAGEAGLSLVDQVGGVMASVPGFQWQAVAPVNVQGDTLTHNLQINVPGFDAMYIELKWKDIDGTWKLTRESECTIAYYANLPCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9P2</accession>
    <name>A0A231H9P2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsS</name>
        <name evidence="7" type="ORF">B7C42_02676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513362.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45551">
        <property type="protein sequence ID" value="OXR45551"/>
        <property type="gene ID" value="B7C42_02676"/>
    </dbReference>
    <dbReference type="GeneID" id="66718915"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="93" mass="10834" checksum="BBFF763740070923" modified="2017-10-25" version="1">MPRSLKKGPFVDEHLLKKVDVQNEKGTKQVIKTWSRRSTIIPDFIGHTFSVHDGRKHVPVFVSENMVGHKLGEFAPTRTFRSHVKEDRKSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Y3</accession>
    <name>A0A231H9Y3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-phosphogluconolactonase</fullName>
            <ecNumber evidence="1">3.1.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgl_1</name>
        <name evidence="1" type="ORF">B7C42_01942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45650">
        <property type="protein sequence ID" value="OXR45650"/>
        <property type="gene ID" value="B7C42_01942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="21168" checksum="9927360AC51BFC82" modified="2017-10-25" version="1">MPLPHAPVDITFAPNGRDGFVTVGAVNASILPIRIDSKGVPSPNGPAVPVGGAVDGLGSAEISPDGHNLYVASVTGRQLVVFDIHDDATLSEVKQRVAGGINTIYPVITPDGRHVFFSNEISGTVQAFNRADDGTSSEVAGSPYQAGLLPHIASTTPDGRFLYVPNMGSSFISSYEIRPDGTLRPLPNVDFAPEPGVKPNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAA8</accession>
    <name>A0A231HAA8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor SdpR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdpR_1</name>
        <name evidence="2" type="ORF">B7C42_01959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45667">
        <property type="protein sequence ID" value="OXR45667"/>
        <property type="gene ID" value="B7C42_01959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11839" checksum="51993EE780A49FCF" modified="2017-10-25" version="1">MVFHALSDSTRRSMLRTLARRQCSVGQLAAPFDISLAAASKHIKVLERAGLVRRNVRGRTHLCRLDPRPLRECAEWVNFYERFWGESLDALEAALLQEDSRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAZ2</accession>
    <name>A0A231HAZ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Long-chain acyl-CoA thioesterase FadM</fullName>
            <ecNumber evidence="1">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fadM</name>
        <name evidence="1" type="ORF">B7C42_02208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778837.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45916">
        <property type="protein sequence ID" value="OXR45916"/>
        <property type="gene ID" value="B7C42_02208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="15472" checksum="F6F5768FD18D81AD" modified="2017-10-25" version="1">MTFSVPVTVRGYELDVNGHLNQAVYHQYAEHARWEVLRAAGLVPDKMRLSGLGPVVLESTVKYRRELHLGDEITVTCECRWGEGKAFWMDQQIRKLDGTVSAEFSVVLGLMDLDARKLVSNPSQRFLELAESPGVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB64</accession>
    <name>A0A231HB64_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress response protein SCP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yceC</name>
        <name evidence="2" type="ORF">B7C42_02289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45996">
        <property type="protein sequence ID" value="OXR45996"/>
        <property type="gene ID" value="B7C42_02289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="177"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="362" mass="38474" checksum="3E76D238AE3EB31F" modified="2017-10-25" version="1">MAAQLTKGQVDRLTHDEVVVSVRHSEPVDVSALLLNSAGRVRDETDLIFYNQPAAHGVRLASGRPELSIGLRSLPPEIEHVRIVASLEDQQDRFGDHAPPQLIVADPSGNAVYEYTVDGLGEEPAVIVADLDRVGSTWQVRPLGHGFPAGFAALVTAHGVAVGGGADELPYRGPAVLAPGQEVALNQIRKGELSMVKMGVGWDPMKVHGPRGLRALEIDLDASALLFVGQTLVDVAFYQQLSSRDGAVRHSGDNLTGDGKGDDEVITVDLARLPAQVTSVVFVVTSYAGHTFERIRNGYWRMIDGSTTAELARGNLRGGGPHTGMVVAKVYRDGGLWRVASIGAPIQAGHPVEAVPLVVPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA9</accession>
    <name>A0A231HBA9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative FAD-containing monooxygenase MymA</fullName>
            <ecNumber evidence="5">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mymA</name>
        <name evidence="5" type="ORF">B7C42_02300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR46007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46007">
        <property type="protein sequence ID" value="OXR46007"/>
        <property type="gene ID" value="B7C42_02300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="499" mass="54643" checksum="FC6E60BE7EEA621D" modified="2017-10-25" version="1">MTRHVDVLIIGAGLSGIGMACHLSRENTGRSYAILERRSAIGGTWDLFRYPGIRSDSDMLTFGYGFRPWIGTKVLADGPHIRQYIADTAEEYGVTRHIRFGRKVVKSSWSSAEQLWTTEALDEQTGDTETYTSNFLVGCTGYYDYDKGFRPQFPGEENFGGQIVHPQHWPEDLDYRGKRVVVIGSGATAITLVPAMSEDAAHVTMLQRSPTYIAPLPAEDPVAVGMKKAKLPAALAYKTGRARNIALQRASFALSRSNPALSRKLLLQAVRVAVGPNVDMRHFSPSYNPWDQRLCIVPNGDLFKVLRSGRASIVTDRIATFTETGIRLESGEELPADIIISATGLNVQMLGGAAIDVDGTSIATRDLVAYKGALMSGLPNAMMIIGYTNASWTLKADLAAEYFCRLLNHMKAEGYSTFVAEAEDADRAPESMMGGALTSGYIARGDAVMPRQGRRGPWKVINNYYRDRALLRKADLEDGILRFGTRSAAARPVAESRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBH8</accession>
    <name>A0A231HBH8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781511.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46221">
        <property type="protein sequence ID" value="OXR46221"/>
        <property type="gene ID" value="B7C42_01187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="312" mass="34984" checksum="635D8B57C1520191" modified="2017-10-25" version="1">MAVSLESWNDGETTSAIVDFVARVTDRDGSGYVEPSARIAVFDNDGTLWCEKPMPIQLDFTIRRLAEMAEQEPELRTRQPWRAAYEQDLQWLGAAMVKHYHGDDDDLKLLMGAVTRAFGEITVEDYDARVAAFFADAAHPTLGRPYHGCGFAPMVELLWYLRDNGFTTYIASGGDRDFMRPVAGDLYGVPPERVIGSALGLTYREQEGRSDLLYKSAMDFFDDGPEKPIRIWSRIGRRPILSVGNSNGDLPMLSFSELAGAPSLRMLILHDDAEREFDYVAGAEDALAHARRNDWTVVSMKNDWAQIFTPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBS7</accession>
    <name>A0A231HBS7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-lytic protease</fullName>
            <ecNumber evidence="2">3.4.21.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alpha-LP_1</name>
        <name evidence="2" type="ORF">B7C42_01122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.12" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46157">
        <property type="protein sequence ID" value="OXR46157"/>
        <property type="gene ID" value="B7C42_01122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011224687" evidence="1">
        <location>
            <begin position="46"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="463" mass="47130" checksum="B7CC65AB212BC095" modified="2017-10-25" version="1">MRKLAARRATIGRASVARASMKTAAVALASTLLLGPWIATSPALADPAPAQSAADQLPPELVQAIGRDLKMSPAEYLDRAARAQQLRDYARDFRSSHPQAFAGAWLGADGKPVMAVTSLDAARIANSAGYQTRLAPISADNLESSLDQLVQWIGGLPRELSAGINSVAIDFLNSQLVLSVANTPAGHLLNLPTLIANVKVVLSPDGGGPVERRPMAGDTYISAPTSLDDSALKSVDVCSFGFNSIDAAGNALNISAGHCDPNVGKGDSEAGVYLPNLRNLKASPQFGTFVKAQLGGSTGLDYSVIKLNERAITAGMDQPSVRGANGTTLTLTGVAEPITGAPICKSGQSSTFTCGFVVADRVETALFTAAGESKTVRGFASSACTLGGDSGGAIVSGTLALGITSGSNAADAPDCKAANMDLAQYGGTATLGIPIRQILSDIDANSGGGLGAGITVRTRPIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBW5</accession>
    <name>A0A231HBW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mutator protein MutT4</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mutT4_2</name>
        <name evidence="5" type="ORF">B7C42_01399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514061.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46433">
        <property type="protein sequence ID" value="OXR46433"/>
        <property type="gene ID" value="B7C42_01399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="151" mass="16797" checksum="E6AC42461CD989FA" modified="2017-10-25" version="1">MRTVRETSAGGLVVDGLDGPAEQRCAALIGRTDRRGRLLWSLPKGHIEEGETAEQTAVREVAEETGINGRVVAELGSIDYWFVTEGRRVHKTVHHYLMRSLGGELSDADVEVTKVAWVPLSELDSRLAYADERRLAEVANRLIDRMESGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCM5</accession>
    <name>A0A231HCM5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative propionyl-CoA carboxylase beta chain 5</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">accD5_2</name>
        <name evidence="4" type="ORF">B7C42_01553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_062994838.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46582">
        <property type="protein sequence ID" value="OXR46582"/>
        <property type="gene ID" value="B7C42_01553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="257"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="514" mass="55612" checksum="71E211758CE7303B" modified="2017-10-25" version="1">MSTTAERLADLRKKLELAQEPAGEAGIAKRAKKGIPSPRERINMLLDPGTFVEIGALVRNPADKNSLYSDGVVTGHGLVEGRPVAVFSHDQTVYGGTVGEMFGQKVASLMRFAAKMGCPLVGINDSGGARVQEAVTSLRWYGEMAIAMEALSGAVPMVSLILGNCAAGAVYQPICTDVVIATESAHMFVTGPQITREATGEDVTADELGGAYRQADWGNIHHVAKDEKAAFEWAREYLSFLPSSCQEEPPIVNPGLEPEITETDLELNTFVPDSDNASYDMHEVLLRIFDDGGFHEVGSDMARNIITGFARVDGRSVGVVANQPMYLAGALDAKASDKASHFVRMCDAFEIPLVLVVDTPGFMPGLEQERAGVIKRGGRFLFSFVEASVPKVTVVVRKAYGGGWAVMGSKALGADVYFAWPTARIAVMGAEQAVGLVGRRQLEAAPEDQREAIRKQMIDFYNATAATPWPAAERGYIDAVIEPSATRLEIRKALTLLRDKRLQRNPRKHHLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCP4</accession>
    <name>A0A231HCP4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46681">
        <property type="protein sequence ID" value="OXR46681"/>
        <property type="gene ID" value="B7C42_01656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8920" checksum="D3044148CBC56AD2" modified="2017-10-25" version="1">MHLPDWHCPTCAAFSILGGEVDEATYELNQRRITAHTSLHTAQLAEHDGDHEALRLRLQNPHHVAAVQSLQTTDERTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCU5</accession>
    <name>A0A231HCU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rmlC</name>
        <name evidence="5" type="ORF">B7C42_01569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775206.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46598">
        <property type="protein sequence ID" value="OXR46598"/>
        <property type="gene ID" value="B7C42_01569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="20458" checksum="BEE27B2D98D76BFA" modified="2017-10-25" version="1">MRIRELAVPGAWEFTPVLRGDERGVFAETFKASEFEKATGRPLDLLQMNTSTSAAGVLRGIHYTENPPGQAKYVTCMRGAFLDVVVDLRRDSPTFGRWDSVVIDDVTRRSVFVSEGLGHALLSLADDSTVTYLCSLEYSPEFDRDLDAFDPDLGIDWPTAGSDGSPLTFIRSPKDAAAPRLRELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD04</accession>
    <name>A0A231HD04_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46800">
        <property type="protein sequence ID" value="OXR46800"/>
        <property type="gene ID" value="B7C42_01778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014488">
        <property type="entry name" value="UCP017371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017371">
        <property type="entry name" value="UCP017371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15431" checksum="B567D808BF9B0CA8" modified="2017-10-25" version="1">MGQVSASSSTVVAAEPQRALEAIADYQDVRPRILSSHYHDYKVLEGGKGAGTVAEWTLQATQKRSRNVHAVVSVSDSMVTERDSNSTLVTTWTVTPSGEGSQVTVRTSWKGAGGVPGFFEGIFAPLGLKKIQAEVLENLKRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD87</accession>
    <name>A0A231HD87_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46677">
        <property type="protein sequence ID" value="OXR46677"/>
        <property type="gene ID" value="B7C42_01652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="308" mass="33588" checksum="EC11B2E62FC72647" modified="2017-10-25" version="1">MTLITPSNPPTQLALQRLLSGLDSVITWVDINGNTEPLSGGLAPTEMGGYGEGLQLVDIKGLGAPFKHIDQQGAHQDGATWLDAPYDPIEIDMTLVAFGRDQIARRRVFRRWMDGWDAKRTGRLWWFTAELGHWWIDLRLLQEMRDTLAAGDARSVKFAWAARGDFPFWSSYDSISTKLVASNATTLADPAGNAAPNFMQVSNRGDQDSWTIILCHGPGTFTIGDNGGPRRITLPLNAGELARIETLPNRRTVVEVNTGANIYPRLVGRFSTPIAAGATVRIPITVTGAQAGVTSAVASLTPLRKWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDR4</accession>
    <name>A0A231HDR4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46847">
        <property type="protein sequence ID" value="OXR46847"/>
        <property type="gene ID" value="B7C42_01825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="357" mass="38962" checksum="3874FAE07B7C2C1D" modified="2017-10-25" version="1">MRAAELPSIPGVLTARQCLATAESIAGQQHSDGAIPWFRGGHTDPWDHVESAMALTVAGLHDAARAAYAWSADTQRADGSWPSQFRGDVVETADTDTNFCAYIATGVWHYYRCTGDRRFVDTMWPTVRAAIDYVISMQQGRNGEIYWLQTEQGILPEALLTGCSSMFHSIGCGLAIAELLGLAQPEWEVAALRLGHALRHHPESFAEKDRYSMDWYYPVLGGALRGEAGHARIASRWSEFVVGEIGIRCVSDRPWVTGAETCELALALDTLGDSDRALRLLASIQHLREDDGSYWTGLVFADGKRWPEERTTWTGAAVVLAADALTRTTGGNGIFRELAPSADIATGLTCDCVRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDU7</accession>
    <name>A0A231HDU7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47064">
        <property type="protein sequence ID" value="OXR47064"/>
        <property type="gene ID" value="B7C42_00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="33488" checksum="0EC4BCD11F58925F" modified="2017-10-25" version="1">MSDLHVATGAGPVGTTIAEQLAATGATVRILTRSGSGPDHPLIERRAVDVNDRHQLAAAVDGATAIYHCIHASQYSARTWRAELPGAEQTILDVAGRTGAVVVFPESLYSYGPVDRPMTENMTRTADFGKPAIRVHLLRAREASPTPTVSVAASDFIGPHVRTSHAGDRMVPNILAGKTVQIFGKADLPHSFTYMPDLAAAMIRAAADSTLWNTFLHAPTAPAVTMRELVAALAEAARMPMPKVVALPGWTLRTAGVVSSMMRELAEMNYQFERPFRLDSTHSERLLGLAPTPLPEVAAGTVAWWKTAVAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEE9</accession>
    <name>A0A231HEE9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fdhD</name>
        <name evidence="4" type="ORF">B7C42_00268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47146">
        <property type="protein sequence ID" value="OXR47146"/>
        <property type="gene ID" value="B7C42_00268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="29548" checksum="8C9450C37B263BF1" modified="2017-10-25" version="1">MSRVTARRPTRRITPAGIVSRPDTLAVEEPLELRVDGTALTVTMRTPGSDIDLLHGFLFSENIIESADDIVSARYCAGTDDEGRNTYNVLDIQLRRAVPVQPRGFVTNSSCGLCGTTALDQVRTRSRFRLPTGSPRVDPAVLATLPDELRSRQTVFDATGGLHAAGLFTPDGTALVVREDIGRHNAVDKVIGWALREGRVPAHDTLLIVSGRASFELVQKAVMAGIPMLGAVSAPSSLAVDLAADNGLTLAGFLRGDTMNIYSGADRLETTPAAATGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF06</accession>
    <name>A0A231HF06_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47315">
        <property type="protein sequence ID" value="OXR47315"/>
        <property type="gene ID" value="B7C42_00438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="177" mass="18228" checksum="AB3E71473F1B7C8C" modified="2017-10-25" version="1">MSFMIGGICGLALTLVFSFTVILQLVHRALDSLSPAAVAVIMVVGAVLVIGMSVRGFLRPPMSLPVHRDLHPVAAIALGLIIWTAQSLTSAPFYGAIAVMADETMASRLGLSTVFVVIAVAPVVALVFALLLCPTEAGHRMLAHLQAALPMTSRVVAALLIVAAVVAAAIGLTIILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF69</accession>
    <name>A0A231HF69_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpD</name>
        <name evidence="11" type="ORF">B7C42_00614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47489">
        <property type="protein sequence ID" value="OXR47489"/>
        <property type="gene ID" value="B7C42_00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="108"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="610"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR47489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="840" mass="89932" checksum="065A4F092B8F4BF4" modified="2017-10-25" version="1">MKRGQLRIYLGAAPGVGKTYAMLGEAHRRIGRDRDVVAAVVETHGRSKTAELLAGIERIPPAMRTYRGTTMPELDVDAVLRRAPAVALVDELAHTNVPGSKNEKRWQDVHELLDAGIDVISTVNVQHLDSLNDVVEQITGVVQRETVPDWVVRGADQVELVDITPEALRRRLSHGNVYTADKVDAALRNYFRPGNLTALRELALLWLADQVDAALAKYRADHKITATWEARERVVVAVTGGPESETIVRRASRIATKSSAELVVVHVVRGDGLAGVSAQRLHRLRELAAGLGSSLHTVTGENVPNALLDFARQVNATQLVVGTSRRSRWARILDQGIGATVVQRSGSIDVHMVTHEEAQRGLRWSALLRRQRPTVSWLAALIVPTLITLVCYLWLDSRLDLAGESAMYFIGVIAVALLGGVAPAALSAVLGGLLLNWFFTTPRHSLTIAEPNNFLTIVVMAGVAVAVAALVDISANRTREARTASREAELLTLFAGAILHGADLPDLLERAREIYRQRAVSFVGDAEVIACVGHDPARTPAAADTAIGAGDEEHWLLLSGRALTPGDRRVLAAVAGQAAALVRQRELADQAQAAAGVMATDRLRRALLSAVSHDLRTPLAAAKAAVSSLRSEDVQFSPADTAELLETIEESTDQLTALVGNLLDSSRLAAGAVEPNLKQVYLEEVVNRAVVGVGMGTRGVRQAAMDRVKVEVGDVSVYADSGLLERVLANLIDNALRYSAPAATTVPDTPVRVGAERDGDRVSITVVDYGPGVPTGLEDQMFEPFQRLGDRDNSTGVGLGLSVVRGFVEAMGGTVHAEPTPGGGLTMVIELPARDTQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFC2</accession>
    <name>A0A231HFC2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47426">
        <property type="protein sequence ID" value="OXR47426"/>
        <property type="gene ID" value="B7C42_00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14290" checksum="57B91F764C0DF9B6" modified="2017-10-25" version="1">MTLPTAYVASAELPKGPPRALGYIDRTLPGWPANEQRVLAHAVKLGYSLVRVVFRAAGDIDDPIMRLLDRIGGYNVAAVVVPSVEHLGERLRIVCAACDVEVVEPEVTYARARPTISSEPASASRASRVEPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFL7</accession>
    <name>A0A231HFL7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddn_3</name>
        <name evidence="3" type="ORF">B7C42_00896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47771">
        <property type="protein sequence ID" value="OXR47771"/>
        <property type="gene ID" value="B7C42_00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15659" checksum="900A6C84678C91EE" modified="2017-10-25" version="1">MSDWNTAIIEEFRANEGRVGGDFEGAPMVLVHHRGRKSGRELVTPMMYLADDENPDSIYVFASKAGAPTNPDWYYNLTTAGTAEIERGTDRYPAAVTEVTGERRDRIFAEQARRYPGFAGYARKTEGIRTIPVLELRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFQ3</accession>
    <name>A0A231HFQ3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_00839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47714">
        <property type="protein sequence ID" value="OXR47714"/>
        <property type="gene ID" value="B7C42_00839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03914">
        <property type="entry name" value="UDG_fam_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="41"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="203" mass="21744" checksum="C70F135DBB373F25" modified="2017-10-25" version="1">MVKAPGAAEFVPDTTDLARLREAACGCHGCDLYKHANRTVFGEGPPHAPMVMIGEQPGDREDLAGHPFVGPAGALLNRALADAGIDRDAVYLTNAVKHFKFTERGKRRIHQKPGRTEIVACTPWLTAELDAIRPQLVVCLGAVAAQAVFGPDFRITRDRGRLIAHDDLRALATIHPAAALRAPDRAEAYDGLVADLTEAATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFS0</accession>
    <name>A0A231HFS0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiseptic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">qacA_1</name>
        <name evidence="7" type="ORF">B7C42_00847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042809.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47722">
        <property type="protein sequence ID" value="OXR47722"/>
        <property type="gene ID" value="B7C42_00847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="507" mass="52254" checksum="E9EBF965EF8A2CBC" modified="2017-10-25" version="1">MIDRNRTATPVRGRWGMLAVLCASLLLVAMDATVLNVALPSLIEDLQPGAVAQLWIVDIYGLVLGGLLITFGAIGDRIGRKRLFLTGFALFGVASMVAATAQVTGQLIGGRVLLAVGGAMVMPSTLSLIRNIFDDPHERTRAIAIWAAIAGVGAAVGPIVGGVLVEHFGWAAAFWINVPVVVLTLAAGIGLLPEYRAPSTTAFDWPSVPLSVLGIVGFVWGVKHLARGEDIVVNVCVLLAGLAMLFWFARRQLWLIDPLLDIRLFRRPVFLAAALATLMAMIAIGAALFLISLWLQYIHGYSPAEAGIRTAPAAAATLIGSLATPALLRRTGVRGVMVTSLLILAAGFAVLAISPEPTSYAVVALVLVCLGIGDGIAVTAAAAVLVSSVPAERAGQGGAVEETSYELGNGLGVALLGSVHGALFTHYMSDVPLAGAQGETARESAGGAIAVAGDIGGELGARVHEMASAAFDSALTITSYAAAGVVATVAVLTAILIPRHTSVTPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFZ7</accession>
    <name>A0A231HFZ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47605">
        <property type="protein sequence ID" value="OXR47605"/>
        <property type="gene ID" value="B7C42_00730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15920" checksum="E87E148790E27376" modified="2017-10-25" version="1">MTTSIASALPAAPQLLCAFQGRRFQDRELLRSARALAELHTRRAQITDPILIAEIDCRRGELIDDINEWVERELPGYRTGVALRTDVLGPMVDRMAGSWVAANRAIDRDGARSDTTHKHWYHLAELVDGYTDLVSGVTAPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG47</accession>
    <name>A0A231HG47_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">recX</name>
        <name evidence="6" type="ORF">B7C42_00821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47696">
        <property type="protein sequence ID" value="OXR47696"/>
        <property type="gene ID" value="B7C42_00821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="597" mass="64084" checksum="BE0A290B10A41D03" modified="2017-10-25" version="1">MPHREAPGSTPLPDPGASRLDAVERLRRQLEEIESRSRRNGDPDDESWSKPVRRQGSSPRRRRSKPGAGDPPTGVWRSDDGPVPQHDSVDDTGTSAPADRPEFEPELPPRIEPEIRSGSISGRPEDGSAARDSQAHNRIRALQAEVDALQRGWGERADGDRRAGSTRRAEGQPKGGDHGSFGPDDSAGAYPRSDDGADDGGSRRRSRRDGGARGERRGSRRSDADGGKRSDAAQSAAPKAGTEAQAKDICLRLLTDRARSRAELVDKLAAKGFAPEVAERALNRLAEVGLIDDAAFAEQWVHSRHTFSGKGKKVLAQELRRKGVSDADAGPALAAITSADETARAAELVRRKLAALPPDLPADKMTNRLVSMLARRGYNQSMAYAVVKDELAAVATESRGPDGSQHTDHVAVDESADGSQPLVVEHHSPKGRREESSGSTATGSASRQSAPASAEHAAQLVRKRLASLSRDIPQDKAMARLVGMLARRGYPQSMAYAVVKEEIAAAAQPFAAQPNRTEKAVVAEDSTAAETAAADSDNDEAERAAELVRRKLRTMPRNLSEDKVVNRLVGMLARQGFRQSTAYAAVRAELAHGYPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSF2</accession>
    <name>A0A231GSF2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000535">
        <property type="protein sequence ID" value="OXR39557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39557">
        <property type="protein sequence ID" value="OXR39557"/>
        <property type="gene ID" value="B7C42_08375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="46" mass="4600" checksum="16904CED74F6A32F" modified="2017-10-25" version="1">MVAPVAPAPGVPAVGNTMLVPVALVAPVPELAVNPLERVSRPFTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT38</accession>
    <name>A0A231GT38_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000081">
        <property type="protein sequence ID" value="OXR39715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780512.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000081.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39715">
        <property type="protein sequence ID" value="OXR39715"/>
        <property type="gene ID" value="B7C42_08217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011301472" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="14861" checksum="BC4A3EC85F7883E4" modified="2017-10-25" version="1">MRIGAITIISAAVAMAGTVIAASPVHAAAKSCNLGFMPAKPTVGVGSIIGNAWAACDVPPERHELRLALQLRTRDGWQGQALISDPGIPSPRLTYSVKTKCLPGMWRVQAQAVGTLQGHPFDFVDSSIERIVTAEECARGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT60</accession>
    <name>A0A231GT60_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000076">
        <property type="protein sequence ID" value="OXR39735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782043.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000076.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39735">
        <property type="protein sequence ID" value="OXR39735"/>
        <property type="gene ID" value="B7C42_08196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="11341" checksum="CC1F1C69E81D460C" modified="2017-10-25" version="1">MGFPITIPAPTTILSRTAPIEELASYDKRDETLIIELGEIDQAGVTYTRSALVKTITAKFDRAADPQRTIVVEFAHPDLEPRTFPLGEQVTVHYLTYEHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT85</accession>
    <name>A0A231GT85_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000059">
        <property type="protein sequence ID" value="OXR39837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39837">
        <property type="protein sequence ID" value="OXR39837"/>
        <property type="gene ID" value="B7C42_08099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02118">
        <property type="entry name" value="TIGR02118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11298" checksum="19E91DEA618E212D" modified="2017-10-25" version="1">MHKLVVLYPEPADPDHFRDYYVNNHLPLVTKWPGLLGWRYSFDVAATNGEAPYFAVFEADFADAAALAAMRASEYGRRAAADVANYATGGVVVIDYPVQEGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTN7</accession>
    <name>A0A231GTN7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39979">
        <property type="protein sequence ID" value="OXR39979"/>
        <property type="gene ID" value="B7C42_07958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="595" mass="63984" checksum="91FF6A8AD684D687" modified="2017-10-25" version="1">MNRTTPRRPVRIGNASGFYGDRFAAFRAMVEGGPVDVVTGDYLAELTMLILWKAKQKDPETGYAKTFLAQFEQVATTCAERGIKVVVNAGGLSPASLAERIRSVVREAGLELSVAHIEGDDVIERLPRLQAEGHPLRHLDKGITLEESGAQPISANVYLGGWGIAAALAGGADVVITPRVTDAALVLGVGAWWHDWKRTDFDALAGAVAAGHIIECGPQATGGNYSQIGEIADRRYPGSPIAELAHDGTFVITKHDGTGGLVSPGTVTAQLLYEVDSPVYLNPDVVAHFDTLRLRQDGTDRVRVSGATGSPPPSTLKVAMNFIGGYRNTMTLVLTGLDIEEKARWATEQLFEILGGRERFDDVDVQLLRYDRAEPTRLSEATAHLRVTVKDRERAKVDRAFSNAVLELAVGGYAGFHTTTPPTSASEFGVYWPTVIPASEIEQIVVHADGSRETIAHTAQTDDRYCGVIPSGDSGSGTADFGPASRRPLGSVVAARSGDKGGKANVGVWTDTDERWDWLRSHLTVEKFVELVPDAAGFEVRRYEFANLRALNFVVVGFLGDGVASCTRTDPQAKGLGEFLRATYTDIPDKLAGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTW8</accession>
    <name>A0A231GTW8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782759.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40059">
        <property type="protein sequence ID" value="OXR40059"/>
        <property type="gene ID" value="B7C42_07863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="45127" checksum="33D662EB031D6341" modified="2017-10-25" version="1">MHAENSLAIGQRIKIHRERAGMSRPVLAGLLGRSGGWLKAVETGRLQTPRLPMLLRIAQALDIEDLAELTGDDHAVPVVVFAGERHAALTQVQSALTDFRITPRDRQPSTQHLAERLRQAWHIRHSSPDHRTQLGALLPGLIRDAQGAARTASGPERRAARKLLAGVYQLADFYVAYQPAPELVWMVADRALEQGYEADDPYVIACSAWGMVQALRDSGRWEEAIDLSRDSIDRLAPYLERDATADDWRGIVGALEAEIAYVYARRGRYGNAWAAWERADEFARRLGPAYRHVQTSFSMPVMSAHAVTLGVELRRSGEALRSASGFDPDDIVSVPRRSRHFIEVARAHTQQGESTAALALLAKSERTAPETIKYNGYARDMVLGLLKSPPAGMRDEVRELGQRVGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTY3</accession>
    <name>A0A231GTY3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative alkyl/aryl-sulfatase YjcS</fullName>
            <ecNumber evidence="7">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yjcS</name>
        <name evidence="7" type="ORF">B7C42_07838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40083">
        <property type="protein sequence ID" value="OXR40083"/>
        <property type="gene ID" value="B7C42_07838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:alkyl sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="6">
        <location>
            <begin position="102"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="631" mass="68339" checksum="40451BD1CCDA99BD" modified="2017-10-25" version="1">MTGQGDVSGSVRTQNEEATRALPFGDDQDFADARRGFIAALEPGVVENAAGDVVWDSDGYAFLDAECPPTVHPSLWRQSKLCAIQGLFEVTEGIYQIRGLDLSNMTVVEGDTGVIVIDPLISRETAAAGLALYRTHRGDRPVTGVIYSHSHIDHFGGVKGVTTPEDVAAGRCPILAPAGFVEHAVEENVYAGTAMGRRAAYMYGAALGRGPKGAVGAGLGPTTSTGTPTLITPTTDITHTGQTEIVDGVRIEFQMTPGTEAPSEMNFYFPDRRALCMAENATHTLHNLLTLRGALVRDPHVWSKYLTESINRYAAQADVLFASHHWPTWGTENLTEFLALQRDLYGYLHDQTLRALNKGAVGIEIAESIELPPALAAAWHTHGYYGSVSHNVKAIYQRYMGWFEGNPATLWEHPPTESAKRHVDFMGGAEQVLKKARDSFAAGDLRWVAQVLNYVIFADPGNREARALQADTFEQLGYGSENGTWRNFFLMGAYELRNGSVGTPTATDAPDIAAALTVEQLFDAIALRIDGPKAWSADITIDWTMSDLDLVHRTQLRNGVLVHYDVSADMPAPDVTFTLSDADLHAALLGAKDMQQLIADGAVTVDGDVSKLIELVGYLDAPDPDFAIVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUR2</accession>
    <name>A0A231GUR2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40364">
        <property type="protein sequence ID" value="OXR40364"/>
        <property type="gene ID" value="B7C42_07530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="28037" checksum="EE29DA0C22AD35E3" modified="2017-10-25" version="1">MTTTSGRPVDVDAGIRARRSGLDVWITFWTFAVFYAVLSIGVVFFGRATPPPRPDVTDLQVQEWFDKHQLGIQIGFCALLVLAGGAAVSNGIIGYFMKRMSSGPVLAYAYIAGMGVGAVPGFQLLLVCWLTATFRPGRDPAIQHTLYDLGMLSYNGSLGCFTAAYTVLAIAILYDRNRVFPKWFAYISVWQVVTEVLATQMWVFHSGAFAWNGMITFYVAIIVFALWVGCLLPILHNATRAEGSNARPLYTGKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUV4</accession>
    <name>A0A231GUV4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40409">
        <property type="protein sequence ID" value="OXR40409"/>
        <property type="gene ID" value="B7C42_07467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11574" checksum="58092A3D9E701268" modified="2017-10-25" version="1">MVGVVAAIGTGIAAALGPVMIIEAVRPHEQALANGMQGMMQGIVTTVVTQVLFVVMARGGVVMQGTQFYRESGFVHAYYVVVGLAVVSLLAVALIPRIRHLDEAEVGQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUV9</accession>
    <name>A0A231GUV9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40335">
        <property type="protein sequence ID" value="OXR40335"/>
        <property type="gene ID" value="B7C42_07596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8168" checksum="4E7C6388ECAE90AE" modified="2017-10-25" version="1">MSYRGPDYPDLGQAEELWPRLSALWNAVREELRLTNPEETSQEPPAPGHAGPVEARPGEGISNTTIRRPTGGSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUY9</accession>
    <name>A0A231GUY9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-dehydroadipyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">paaF_6</name>
        <name evidence="1" type="ORF">B7C42_07498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40440">
        <property type="protein sequence ID" value="OXR40440"/>
        <property type="gene ID" value="B7C42_07498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="35742" checksum="A3A9409FB1807169" modified="2017-10-25" version="1">MLKEISNAPRGTFDPYQPALLDERGTIAEPVVIVELDSLPDRFSLPNERVSIGVATGPMSPAARMVAPSLDITIVPSGLDDQVWTVGAEDPAKTAEALAVAVRANPTAAVVLAQVLRMTGLGVADGLNVESYAYSTLLGGDEFAAWLTRRGHRPAPPSATVDPVLVQRERNELRVTLNRPERRNAFGREVRDALVNALRLVAVDESIDHVVLDGAGPSFCAGGDLDEFGTTPSPVLAHFVRTAAGAGRLLHSISARLEARLHGQCVGAGIELPAFAGRVVAAPGTGFRLPEVAMGLIPGAGGTVSIPRRIGRWRTLKLALSGESIAAETALAWGLIDAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV79</accession>
    <name>A0A231GV79_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_07445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40506">
        <property type="protein sequence ID" value="OXR40506"/>
        <property type="gene ID" value="B7C42_07445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="47390" checksum="2F0422725B0B0215" modified="2017-10-25" version="1">MSDVTTAEVADTAAVAKRKDAKTGVDVELVGKLVAQARENGLELSGEGGLLQQLTKMVVESALDGEITDHLGYEHSSPAGRGTGNSRNGTRSKTVVTDIGPVEIDVPRDRDGSFEPQIVRKRQRRLNGVENMVLSLSAKGLTHGEISAHLREVYGAEVSKQTISTITDKVLEGMAEWQNRPLDAVYPVIFLDAIHVKIRDGKVANRPIYVALAVTCDGTRDILGLWAGDGGEGAKFWFQILTELKNRGIGDVCMLVCDGLKGLPDAIGEVWPAAVVQTCVVHLLRASFRYAARQHWDSIAKALKPVYTAPTESAALERFYEFAETWGGKYPAIVKLWENAWSEFVPFLAFDPEIRRVVCSTNAIESVNARIRRAVRARGHFPNDQAALKCVYMAIMSLDPTGAGQKRWVTRWKAALNAFDITFEGRLSTGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV99</accession>
    <name>A0A231GV99_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778716.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40549">
        <property type="protein sequence ID" value="OXR40549"/>
        <property type="gene ID" value="B7C42_07358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="24910" checksum="D03EE29AA0555F32" modified="2017-10-25" version="1">MRITIFGANGPTGRRLTAQALAAGHQVAAVTRQPGEFPLRHDRLEVIGADVLDPGAVDTAVKGRDAVLSALGVPPSKEPITTYSDGVSNIVTAMRRHGVGRIVVVSSAGVDPRPYSEGGFLFNRLLVPYVTRVAGKTLYDDMRRMEALLRDSDRDWTVVRPSGLYDRPDVTDYTMVEGHADGIFTARSDLAASMLAAVTEGRFVRAAAGVITTDSGNPTLLRWIRQQASAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVN9</accession>
    <name>A0A231GVN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">drrA_13</name>
        <name evidence="6" type="ORF">B7C42_07350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40541">
        <property type="protein sequence ID" value="OXR40541"/>
        <property type="gene ID" value="B7C42_07350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="33517" checksum="6C361E41F488BB26" modified="2017-10-25" version="1">MNSTAIAAAGLRKAYGDKTILDGIDLTIEAGTIFSLLGPNGAGKTTTVNVLTTLAKADGGTARIAGHDLATEGKAVRAAIGVTGQFAAVDDLLTGEENLRLMAGLHRLRGDAGKRVVADLLERFDLVESAGKRAATYSGGMRRKLDLAMTLVTKPQIVFLDEPTTGLDPRSRRTMWDIVRELTSEGVTIFLTTQYLEEADQLADRIAVLDQGRIVAEGTPDDLKRLVPGSHIQLRFTQPEELDAAARSLPGATRDDSALTLRVPGNGGTKSLRHLLDRLAESSVEAEEVTVHTPDLDDVFLSLTGHATTEVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVU3</accession>
    <name>A0A231GVU3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scpA_2</name>
        <name evidence="2" type="ORF">B7C42_07256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042319.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40698">
        <property type="protein sequence ID" value="OXR40698"/>
        <property type="gene ID" value="B7C42_07256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="32060" checksum="6CA125DFCE94F35B" modified="2017-10-25" version="1">MSEAGPPAAEVVPEDKPDGFHLRLSNFQGPFDLLLQLISQRRLDVTEVALHKVTDEFIAYTKELTASLERDPTLRADRILDQTTEFLVVAATLLDLKAARLLPSGEVTDADDLELLEARDLLFARLLQYRAFKQVAELLGELEAAALRRYPRAVSLEERFLDLLPEVSLGVDAAGFADIAAAAFRPRPRPTVGLDHLHAHSISVAEQAALVLEMLKKRGVGEWSTFHDLCADCEMPIQIVARFLALLELYRGKTIEFDQPDPLGPLAVRWIGDDAEGAPAEPVTIDEDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW12</accession>
    <name>A0A231GW12_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40809">
        <property type="protein sequence ID" value="OXR40809"/>
        <property type="gene ID" value="B7C42_07093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1645"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1723"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1855"/>
            <end position="1875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1875" mass="187452" checksum="3B2E1C517B1E70E7" modified="2017-10-25" version="1">MTLRLPPELPDWAVKGVAGESFPKFDEDIGYATSECISDCMERWKNLGPRLDRLAAMESLALTGMTESEKGDVRNRPMLADISNTHDYGQSLAAFTSSASGNYQYTKWRIIWTLVAMVAMVATDIFVGGPLKAAADRARSEAIIVAARNRLLAWVERIGAESAAKRALIPMARVARLSAPFMKIAGIGAVFGGGVDLAAQMSQKYIDHRRDEIDFGSVGKQALLGGVTGLAGAAFGLYAAPRAGRLFQRFAGGAGATASRVVPTLVVGVGGGLVGSVVGVGANALISGGKLSGQDLLDAAVAGFGGGFVGSVIPAGRAIKGGALAPRLSEPPPTSAPRTAGAGSAGRPVNSPSPVALGELHPLDSAIAPPSGRRGDQFGLVAAADPHNPSNPNAFNAGGPRGKPEGSPGEPPSEGSGVGERNAGNPPGTTARGPEAGAPSGNQVGPLPEHGGQPPPKAEAPPATPPPRGPAETPPSGGSPAPSRGSGTAAGPRTGEQPPSAPVSAHGETGTGSAPVRPEGGQLPVDPRGGPAPSEPVAGPGSGRADEGSPWGESEPSPWGEREPSPWGEREPSPWGESDGPSRTGAAEPPQGTSFSPKEADTPQVTPPAVPSEAPSSGGAPPMQEGPGNRAGESPAVPPPGEAIAGDSAESGPVPKAPEGSSGPGTDRGPYNEDGYNSRGYDEQGYDRNGYDENGYDKWGCKEDGYDDHGFNRLGYDADGYGRDGYNDRGYNRAGYDRDGTLHPERAVALGEAGSDPSSSQVNRTGVDNRSNDPNAGSGRRDPAGPDGNKPNSGAGAEGSAPRAKAGADGGVPLLQDVWNGRAGVASADDVGRLVAGYDFPEGVPQNRVQIAINDALRVTRQSGGDFGDFVKNVDTRLKAYKISLEESPGAPQRPTGEQTPGGPGGVPVPGDPATGSPGSGEAAPPTGVAKAAEPGEGSSTGQRASGNDRNGSDGYDSAGYDRDGFDRDGYDRGGYDRRGYDKEGYQRNGYNEEGYDRYGNKRYDPDSRYDSAGYDEAGYDRSGYNEAGYNRSGYDRDGYKRDGYDDAGYDRNGYNRSGYDRDGFDRNGYDSEGYDRDGYHADEYLGGRRPAGDRGDEGRGGGSDGGPSTPTPPGPRNADEPPLPRDPDGTPRSTPPPLGRPPENPAARPDGDGEGAGGSGTPAKGDDSSGGADTGGSAKGEGEAGKSGGYDKDGYDRDGYDKDGFDRDGYSREGYNKDGYNRAGYDKDGYSRGGYDKDGYDRSGAHRDGYDENGYDPNGYDRAGFDRGGYSRDGYDKNGYNRGGFDKDGYDRGGYDKDGYNRAGAHRDGYDAQGYDPNGFDKDGYNRAGFNREGYDKNGYNAAGRHKDDVDGSKDSGDGSGKKDSGDENSANKSEGTDDKAAGDKNKDDKSDKDKKKSDDDDDDGDKKKMGKGKKFLLAAAAVGAVGYFASNHWSPWGHQGDDGGSGDGSGEGSGSGSGSGSGSPAPITPTVPSTATEPTPLTPTAPSGYAYTPTSPSALTPTQLGPSSSGSAPNDGAWSNDPTSLDPTTPGSQPTTPGSLPGDGSSSDGSGSLGQDPSQLSPASLGSGSSGILGGGGMGGDPMGGMGNLLGAAVAAMTMMSMGSGMGADDSGQDPYYDDGAIAQAPPPAPAPAPAADTGEGSGSGEGSGSGSGEGSGSGSGEGSGSGSGDGSGSGSGSGSGDGSGSGSGEGSGSGDGSGSGSGHGSGSGSGHGHGHGSGSGSGDASGSGSGDGSASGSGNASGSGSGDGSASGSGNASGSGSGDGSASGSGDASASGSGDASGSGSGTTSASGQGSGTTSAHSSGSGETANSGADAANSSADSNPVGEPTAVPANYRPGDRWQFGISPPGSHPWQRLATTGPANSANPPPTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW16</accession>
    <name>A0A231GW16_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40681">
        <property type="protein sequence ID" value="OXR40681"/>
        <property type="gene ID" value="B7C42_07239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="834"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="903" mass="95659" checksum="80B8D2DC013FC9D7" modified="2017-10-25" version="1">MSLVGRESELKYLDEAIAGIEERGGVVVIAGEAGIGKTALLQAVTTMATLAGVRTVTVTATEAEQQLPYAGLHQIVFPLRSGLDALPPTHAAALNAALGFVDAAAPNEYLIGSALLTLLSDRAAEQPLLLVVEDVHWLDAATSRVLAFLARRLESEPILLIASTRDADTALTPAGHATLALSRLAEEEARQLLDTVAPGLDNQRRERVLAAAAGNPLALKELPSAADRPDAPLPLTERLERAFGLRADQLPETTRTALLLAALDELSVPETLAAAALLTDGPIEDAELTPAVAAGLIEIDSGAVRFRHPLMRSAIPAAAQPAARRAAHHALASTLRDQPDRAARHHAAAVVGPDDTAAAELEAAAERALRRGGVAAAITTLEHAAHLTETPAVRVGRLLRAAELAVESGGRETVDRLLREAGRQELDPRGRALATWLVSGFDDGVGEDPARTTELATLAETVAAEGDRELALRILWGTAMRCFWSEPGPDARRALLAVADGMGLPAGDPRLVAITAYVAPVERGATVFDQLRALAGRTGADPEVDRYLGSAALQIGAFVLAGRFSATAITGLREQGRLGLLTRALAVRAWSCARTGDLAGGAAAAAEAERLGPETGQHFMYGLAVAVAAEIAALRGDFDEAAHRADEAERIGAAAGARPVLATVQRARALVALGQGRYDDALADLRRILDPADPAYQLALRAYIVGDLVEAAVRAGRVEEAAEIVREFEEHAPRTPSPALHVGLRYARALLASADAAEELFTAALDADPDGWPLERARVELAFGEWLRRQRRIVESRAHLRAARDTFDALGARPWGERARRELRGAGETSPRRDPDARDSLTPHELGIAQLAAEGLTNREIGQRLYLSHRTVSTHLHRIFPKLGVTSRAELADALRTSADPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWZ7</accession>
    <name>A0A231GWZ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41126">
        <property type="protein sequence ID" value="OXR41126"/>
        <property type="gene ID" value="B7C42_06721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="27930" checksum="0076FF264E8B568B" modified="2017-10-25" version="1">MRRARGRVTRCRKGCRIGCIAVDTTGGAGEPPDPISGSVGASMRRLMFVVWWSAIFHCVPNLLVTVGDLASNLASRRCGISRTLCDRGDSADGCNPVDLHGSGRRAREDTARIVPGWLITQRSQVQILSPLLVKRSRNQGSGTFFVSHRGLCVFSPWPLCVLAATGRGPAAAHRGFAAHERRARRVRSGRQCGCCGSGEANSQAVRGFRPRYRPRGSGARHSVPTAGKAWSGQILFSNYESCAVVRTPKGILVIDHGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX12</accession>
    <name>A0A231GX12_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">clpB_3</name>
        <name evidence="12" type="synonym">clpB</name>
        <name evidence="14" type="ORF">B7C42_06875</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41105">
        <property type="protein sequence ID" value="OXR41105"/>
        <property type="gene ID" value="B7C42_06875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="404"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR41105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="876" mass="96909" checksum="EE7862F856A0A9C3" modified="2017-10-25" version="1">MDTGSLTERSREALQEAQNIATRMGHTEVDGEHLLLALVDQPEGLVPRLLEQTGADVDTLRSDLQGELSRRPKVSGPGATPGQVMITQRLAKLLDAAEREAKRLKDSYVSVEHLVMALSEEGSASAAGRVLARHGVTREAFLTALTTVRGNQRVTSATPEGAYEALEKYGRDLVSEGRAGKLDPVIGRDAEIRRVTQILSRKTKNNPVLIGDPGVGKTAIVEGLAQRIVRGDVPEGLRDKTIFSLDMGSLVAGAKYRGEFEERLQAVLSEVKAAEGRILLFVDELHTVVGAGSGGEGSLDAGNMLKPMLARGELHMIGATTLEEYRKHIESDAALERRFQTVLVDEPSIEDAISILRGLRERLEVFHGVKIQDGALVAAVTLSHRYITDRYLPDKAIDLVDEACARLRTEIDSMPAELDELTRKVTRLEIEEAALSKETDAASKARLEELRKELADLRAEADARHAQWEAERQAIRRVQELRGELERLRHEAEEAERNYDLNRAAELRYGEITELERRLTAAEEQLSARQGRNPLLREVVTEDEIAEIVAAWTGIPVARLQEGEREKLLKLDEILHERVVGQEEAVQLVADAVIRARSGIRDPRRPIGSFIFLGPTGVGKTELAKTLASALFDSEDNMVRLDMSEYQERHTVSRLIGAPPGYVGYDEGGQLTEAVRRKPYSVVLFDEIEKAHADVFNTLLQVLDDGRITDSQGRQVDFRNTVIIMTSNIGSQYLLGGVTADGEITPDARERVLAELRGHFRPEFLNRVDDIVLFTPLTLPQIEHIVELQLTDLRNRLSERQIHLDITPEARRLIAEHGFDPVYGARPLRRYIAHEVETRIGRALLRGEIEAGGTIRVTVAGGELAVAYAEPAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX17</accession>
    <name>A0A231GX17_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41122">
        <property type="protein sequence ID" value="OXR41122"/>
        <property type="gene ID" value="B7C42_06892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_12" evidence="1">
        <location>
            <begin position="305"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="443" mass="47656" checksum="BFE30371BD345BD8" modified="2017-10-25" version="1">MTTDHTNAAIAADAATNAILADMDSNHRSIVVDSPPGAGKSTLVVRAAGHLVEHDERPIVVAQTNNQVDDMVARLSAEHPNLTIGRLSGSTYTPTPAVSAAATVGQKLSDLAGCQIIVGTSKKWATVPDGRFGWAILDESYQMRSDTLLQIVERFDRGLFVGDPGQLDPFTMVDTERWIGLPHDPTLNGVTVMLDHNPSTPVHRLPVSWRLPATAAPTVAEAFYPFAPPFASGTGPGARTIECRTTGFGNTDLDETLATAFSTGWALHELPRRHVPRTDGETIQAAADLAARILNRGAVASCERHRDGRDLTAADIAIGVAHRDQADLVRIALSRTGHPHARRVAVNTANRLQGQEFEVMIVVHPLSGRRDATSFHLEAGRLCVLASRHRHACIVVAREGIPDLLDSHPSTEPVHLGVAAKFPDGWEANQVIMAKLAEHRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXF8</accession>
    <name>A0A231GXF8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-hydroxyisocaproyl-CoA dehydratase activator</fullName>
            <ecNumber evidence="5">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hadI</name>
        <name evidence="5" type="ORF">B7C42_06643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41245">
        <property type="protein sequence ID" value="OXR41245"/>
        <property type="gene ID" value="B7C42_06643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="4">
        <location>
            <begin position="10"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="32208" checksum="50406E0DAC079D7E" modified="2017-10-25" version="1">MTTGNWFVMGVDLGSTTAKAVVVDSTGALCGADVVQMGAVSPAAVACAIDGALGAAGVRSDAIRRTISTGYGRKLVPGADRSFTEITCHARGAAALRQGVRLVIDIGGQDSKAIIVDDEGLVDRFAMNDRCASGTGRFFDVLARALEVDVGEVGELALSGSDDLEVSSMCATFAETEVISLLAQGRAKADIAASVHKAVAARTLGLVAQVGKATPAVMTGGVAKNAAALHYVSRALGGPVELLDQPQIAGAYGAGLLARDEYLGAAASPADRDGAAERQVAAAISAVTPHCQECDGQLDHAPHRGPTTLELRRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXQ2</accession>
    <name>A0A231GXQ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41413">
        <property type="protein sequence ID" value="OXR41413"/>
        <property type="gene ID" value="B7C42_06556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C_1" evidence="4">
        <location>
            <begin position="96"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="27081" checksum="FED9F0C465D2CE12" modified="2017-10-25" version="1">MTEEVPGPLIWSLPEPPGRPTTNLSRAGILRAGMAIADAEGARALTMRRVAQAVGASTPMSLYRYVGSKDGLVDLMIDAVYGEVPLSAGPDSASTAQWRDALEHLALNTWDVIRRHLWFGELVHTRPPLGPNALRYFDFRFAMLEPLGLSADDLSLLTGAVDGHLFGAALQAAEEQRMRTRVGLATDDQLARAAKPLVEPLLEEGRYPAFTRWFHSRTGSGPADPVVWTLRCLLDGITARMGLDEPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY12</accession>
    <name>A0A231GY12_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease YtrF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ytrF_2</name>
        <name evidence="9" type="ORF">B7C42_06564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41421">
        <property type="protein sequence ID" value="OXR41421"/>
        <property type="gene ID" value="B7C42_06564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="292"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="486"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="740"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="839" mass="86652" checksum="491C3D0B085AAD38" modified="2017-10-25" version="1">MAGSPMRKVALRNLAAHKVRLALTLLSVVLGTAFVAGSFVFTDTLQRTFDGIFADQAKGVDVRVEPKHTQSLGVPNDLVAKVAATDGVRAVAPAVQGPVVLLKDGHAVQTGGAPSWGRSYLPPDKAIADPEHFVDGVAPVTPGQIAINSGGADRAGLHVGDKAKVLIPSRGTIDMTVSGIYTVSSDTGGFIGLLLDDAQARELFTDGAHVAYVDVAAVPGVSPDTLRDRIAKVAPDYKVMDGDQVRADLKAQVGNALKFVNYFLLAFGAIALLVGTFIIYNTFSMIVAQRLRELALLRAVGAGRRQVGLSVVAEAFVIGLIGSLLGLAGGIGLAFGLSALLNAFDLGLPTGTMQVLPRTVLAAIGIGLVVTVASAYAPARRAAKIPPVEAMREEFASVGESLRVRTVIGAVLAVIGVVLVALGARNTGGNAAATVGIGAAALIFAVLFASPALSRPVVGALGLLVRPFGAIGAMARNNAVRNPRRTAATAFALTLGLMLVSAIGMLGASAKASVGELVDKGVNADYVLAGPQMIGVPLGAAEAARSVPDVSDVVAFRGVALRVGDDQVTGTSPDAPMGQVLHYDIRQGTDNLTGESLLVSETEAGDRHWHAGDRVEVTSVDNKKFSVTVAGIYADSQLLGPLVVAPDLYNQVMPVAFRTDLIVLVKAAPGADVAAMRGNLEKATASYVVVQVQDREEFKGAQGKQINTMLAILYGLLALAVVIAILGIVNTLALSVVERRREIGMLRAVGMQRPQVRRTIYLESMLIAIFGAVVGVVLGLGLGVGFLRTLSDLGLSTITVPWGQIVGMLIGSAVVGVLAALWPGVRAARTPPLAAIADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY48</accession>
    <name>A0A231GY48_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41492">
        <property type="protein sequence ID" value="OXR41492"/>
        <property type="gene ID" value="B7C42_06384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="36954" checksum="21AE6DF6C290CA25" modified="2017-10-25" version="1">MPPYALPGTEVGPRRARILGIGAVALAAVIIVGWRLLPDSRPADELRVDLVTAQVGEGVGPGTDVRLDGVRVGSVTAVAMAGAGRQRVELALRRSQLFGLTDALTVDYAPGNLFGITALQLNPITGGTRLRDGSTVDLSDRDADRVRDATLAALLESTGRLTDDVLTPKLTEVLRTTSHDIGAFTPLLQAIGTTARSYTETRQLPASLVFAQFGSALHGVPALLAGAAELLHADLTNQQLATKENVDRFSEMFNRVQNEMLPVATDTLYTAQRNTGGLLPIAVTMLDQIAGSVSDPQRSEGELRELLDRLGAGFHDSPAGPVLNAHVDLTTVPGLAVPLAALLSHQPGAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY77</accession>
    <name>A0A231GY77_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41522">
        <property type="protein sequence ID" value="OXR41522"/>
        <property type="gene ID" value="B7C42_06414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="20624" checksum="2AC04D17676A5AF0" modified="2017-10-25" version="1">MRPDILNHGYRPGTKLLFRAVRLFSGQPLPDAAKLVFYRPDFYGARAKAFTHAAMRGPSEWSVADRELMAAYVSKVNASAFCIGAHSATAGQAYADDAKVRAVLDDPESAPIGAGLRETLLLLGAVTRDGEISADDVRKVLSAGVSPQQVEDALAVCAAFNTTNRLADAFGFDVLSPEGFGAGAKYLLKRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY80</accession>
    <name>A0A231GY80_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent glucose-6-phosphate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd1_4</name>
        <name evidence="2" type="ORF">B7C42_06427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780938.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41535">
        <property type="protein sequence ID" value="OXR41535"/>
        <property type="gene ID" value="B7C42_06427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052749">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase (coenzyme F420) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="36345" checksum="E1CE19CA3822C681" modified="2017-10-25" version="1">MRFGIFIPQGWRLDLVGIEPGAQWGVMRDLAQRADAGQDWESLWVYDHFHTVPVPTEEATHEAWTLMSAFAATTTRIRLGQMCTAISYRNPAYLAKVAATVDLVSGGRVEMGIGGGWYEHEWRAYGYGFPSAGERLGRLDEGVQIFRQAWTTGTATLDGKYYQVDGARVYPLPLQDGGIPIWVAGGGEKVTLRIAAQYAQYTNFAGDPETFTRKSELLRDHCAAVGTDFDAITRSSNFNTVIGATEAEVRERLAALTSRLTPALGADAAQDWVTKLYADSPAVGTPEQIVENLSRVRDLGLSYAIHNFPESAYDLSGVELFEREVIPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYN9</accession>
    <name>A0A231GYN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41692">
        <property type="protein sequence ID" value="OXR41692"/>
        <property type="gene ID" value="B7C42_06333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="15614" checksum="8F2B7EDE560960F6" modified="2017-10-25" version="1">MSGKPAPTAAAVASDLRVAVSRLLRQLRAQAEGSDLTKSQSSVLIRLEQGGPATATQLAHAAGMRPQSMAKIVRALEEAGLIAGTPDPADGRKTVLDLTEAARDEFRTGRRAKEDWLTRVIEAEFTDAEIRQLADAVGLLDRIGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZD5</accession>
    <name>A0A231GZD5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase YtpA</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytpA_3</name>
        <name evidence="2" type="ORF">B7C42_05970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41986">
        <property type="protein sequence ID" value="OXR41986"/>
        <property type="gene ID" value="B7C42_05970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="30"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29189" checksum="C7D10489FB4EE8D5" modified="2017-10-25" version="1">MSDISTADFSAADFPGATGSVHYRRWIPPRPRAVLAFFHGLGEHVGSYHPFAAALNSAGIAVWANDHAGHGRSDGERVLISSVDTLIDDAETLVGLARAAHPDVPLIVAGHSLGALVSALLVAERDVPAAALVLAGSSLLVEGESWVLRVLADGVDPWELRRDPSEMTRDTAYAQQIREDPLTWQGGLRLETLGALGAVAPRIPAALDTLTQPVLFVHGAEDDMAPVAGVHRAVAQLPDARAAVFPEDRHNILNEIDRDQVYRVVVDFIAEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZQ4</accession>
    <name>A0A231GZQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome p450 CYP199A2</fullName>
            <ecNumber evidence="4">1.14.99.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.15" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42107">
        <property type="protein sequence ID" value="OXR42107"/>
        <property type="gene ID" value="B7C42_05706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018690">
        <property type="term" value="F:4-methoxybenzoate monooxygenase (O-demethylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="400" mass="44453" checksum="1D90C992D1E42EDC" modified="2017-10-25" version="1">MRKHARIPTYEPNLYSPRAVRDTYPHYARLRELGPVVWLARQKAYALPRYAECKQALLDDTTFISGAGVALNPLTNRLSRGTTLNSDGDDHARRRALLSPHLTPRALRAMRESVDEQADAVVAAAADQGHVDGVELATALPMSVVPDLIGWPHEGREHLLRWAGATFDALGPFNWRTARSTPSGVEMMRFARRVARERSILPGGAGRDVLEAADEGTLPRAQCPALLIDYLAPSLDTTISAISSALYLLATHPEQWRLLKSDPSLIPNTVNEVVRYHSPIRAFSRKTVRDVEIAGASIDKGARVVVIYGSANRDPLEWEAPDTFDIRRDAARQLGFGRGTHGCAGQGLARLETQAILRALTERIDHIEVAGRPEWAMNNIIHRYARLPLRLIPAREREHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZR8</accession>
    <name>A0A231GZR8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42011">
        <property type="protein sequence ID" value="OXR42011"/>
        <property type="gene ID" value="B7C42_05995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="28966" checksum="FD70D0822FA00754" modified="2017-10-25" version="1">MAIDDPAQIRTDIPHSARIWNFWMGGKDNYEVDRAVGEASLQIDPDIATMAVQSRQFLIRAVRHLAGETGIRQFLDIGTGLPTMQNTHEVAQSVAPDAKVVYVDHDPLVLAHARALLTSTTPEGVTTYVNADFHEPEKIIAEAEAILDLQQPVAVMFMGVLGHARSYEDMLRIVRTVLAAVPSGSYLVLWDGTDDSQPYVDLCAEYAKTGGTPYYPRTRAEIAAAFDGLEFVEPGFTCITQWQADSSEVGRTAEIAAYGGVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZV5</accession>
    <name>A0A231GZV5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Enterobactin exporter EntS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">entS_2</name>
        <name evidence="8" type="ORF">B7C42_05738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42139">
        <property type="protein sequence ID" value="OXR42139"/>
        <property type="gene ID" value="B7C42_05738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="34"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="456" mass="48301" checksum="78AABAEE2CCE73AE" modified="2017-10-25" version="1">MTAIRTDDYPTTTAPDTLPPDLPAPAPPERTGGMFASLTVPNYRYYFAGQVVSNTGTWMQRIAQDWLVLGLTGSSFAVGITTAMQFLPMLLFGLYGGVIADRVPKRRLLVLTQATMGVLAAVLAVLTLTGTVEVWHVYLLAFLLGMVTVVDNPTRQSFVPEIVGRQRLRNAVSLNSANFQAARLVGPAVAGALIAAVGSGWAFAINACSFAAVIAGLLAMRPSELTPVPRLPRRKGQLRDGLRYVRAHPQLLWPIVMVGFIGTFGYNFPTVLSGFAYHVFDVDAGKYGLLNTALAVGSLAGALLASRRGRVRMRMLVATAVGFGALEAVTAFAPDYWLFTVLLAVVGLLGLTFNTSGNSMVQLETDPAMRGRVMSLYMMVFTGGTPIGGPIVGWLTEEFGPRLGLFACGAVSAASAALIGLVLARAAGLRLRISGRRVALVPRDGSPAAVSTARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H071</accession>
    <name>A0A231H071_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779733.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42249">
        <property type="protein sequence ID" value="OXR42249"/>
        <property type="gene ID" value="B7C42_05848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="328"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="43563" checksum="ADCDB2E4982202C8" modified="2017-10-25" version="1">MAESPLHDPPVRELGEVAAYLPRLTAVISDRLIAMQPERDRRSNRAIVAATAIALDYTSAVIDGRGCVESLGALEQSAVRWARQGVELPTITHCLHKGMRMVIDELSTAFDAQTNARVFFVLFSALKTLGVTVSRAYMGELTRGPHNPEGAEYSIASAVLAGRDMRVAARDAGIALADTYWVFAIAFGEPLGSRARIRTWWGSARHELVRQRRLRGGGDPLAVVGRDLATVLVPTSQLAEADTAGVAELLSQTLGRPIHAVVEGADRRALRRTANTGHELVRLARRTGYPGGLYRFGDLAVERLLARPCVERDRLAAMIAPLIDCPYLLDTLRAHLATGLSRPRTIESLHIHLNTLDYRLRRIERLTGLDPRDPAQQFRLRAALIAYDSARPDRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0P2</accession>
    <name>A0A231H0P2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper chaperone CopZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">copZ</name>
        <name evidence="4" type="ORF">B7C42_05620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515214.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42419">
        <property type="protein sequence ID" value="OXR42419"/>
        <property type="gene ID" value="B7C42_05620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="6862" checksum="C8A216A0A6632748" modified="2017-10-25" version="1">MATSTYTVTGMTCGHCVASVQKEIGKIDGVTSVDVDLASGRVQVESAAPLTDAEVVAAVDEAGYQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0T4</accession>
    <name>A0A231H0T4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent hydroxymycolic acid dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd2_7</name>
        <name evidence="2" type="ORF">B7C42_05618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42417">
        <property type="protein sequence ID" value="OXR42417"/>
        <property type="gene ID" value="B7C42_05618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="33046" checksum="D772357218A7C0A0" modified="2017-10-25" version="1">MTDSSSHDRAPRNSGLPDAMRAAHGVKVGIGLPIADPQSLVEWAERAESGPFATLGLLDRLVYDNPEPLVTLALLAGATQRIRLQTEVLIAPLRETALLAKQTATLDRLSGGRFTLGLGVGGRADDHEASGTELRTRGKRLDEQVAAMRRLWSGEPYSESCGAIGPRPHTPGGPELLFGGFQTAALERVARWGGGFLAAAAPSWAPGLFDTVHRFWREYDRPGEPRIVAQVNAALGSDAVIDEARSAMAAYYEFSGRAEFMVEGMLTTPDQIRTVTKQFADLGADEVIFYCYGRDPGQVDRLADALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0W4</accession>
    <name>A0A231H0W4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator TtgW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ttgW_2</name>
        <name evidence="5" type="ORF">B7C42_05262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778089.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42486">
        <property type="protein sequence ID" value="OXR42486"/>
        <property type="gene ID" value="B7C42_05262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20482" checksum="5A351FC65134C79E" modified="2017-10-25" version="1">MNDTPSTRRKPRADARRNRQSLLAAADTVFAEGGVDAPLEQVARRAGVGIGTLYGHFATRRALVAALLSERNETLFDRGENLCERQQDSAGNLAAWVALVVEHAATYQGLAALLAEGAHDDDHELHADCARMDRITERLTERARDAGALRAEVTAADIATLINAAAWTREQAGADRAQRLIAVARTGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1H8</accession>
    <name>A0A231H1H8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">clpS</name>
        <name evidence="3" type="ORF">B7C42_05032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42696">
        <property type="protein sequence ID" value="OXR42696"/>
        <property type="gene ID" value="B7C42_05032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15887" checksum="5EFBD65E5B522702" modified="2017-10-25" version="1">MRDAVRIAAGPVGANQAAARATGPQDTAWRGRSWAGRDTRVGVVAGRLSAAQATPETVEVTEILEAEDRPWVTVVWDDPVNLMHYVTYIFQKLFGYSKAKATELMLQVHNEGKAVVSSGSRDRMEHDVQRLHAAGLWATMQRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1I5</accession>
    <name>A0A231H1I5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42713">
        <property type="protein sequence ID" value="OXR42713"/>
        <property type="gene ID" value="B7C42_05050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="16435" checksum="ECB4C824CD0E0545" modified="2017-10-25" version="1">MSYEPTDIELKNLLDHWIGQWNEPDADRRRELIREVWAEDGYQILVNPPEGIRDTARQYGVPAPAVEVRGYDAMFARVTRAYEMFVADGEHFFEAEGEPVRHAGAAVALTWVMRSRADGTVAGSGLEVLTFDPDGRVRTDHEFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1J0</accession>
    <name>A0A231H1J0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">O-phosphoserine sulfhydrylase</fullName>
            <ecNumber evidence="9">2.5.1.113</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysM_1</name>
        <name evidence="9" type="ORF">B7C42_05037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.113" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42701">
        <property type="protein sequence ID" value="OXR42701"/>
        <property type="gene ID" value="B7C42_05037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="11"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="34693" checksum="8B4E21B99B44002A" modified="2017-10-25" version="1">MARYESLIETLGNTPLVGLKTLSPRWDGDDHVRLWAKLEDRNPTGSIKDRPALRMIEQAEADGTLRPGCTILEPTSGNTGISLAMAAKLKGYRLICVMPENTSVERRQLLTMFGAEIIDSPAAGGSNQAVAKAKQIAAEHPDWVMLYQYGNPANADAHYRGTGPEILADLPEITHFVAGLGTTGTLMGTGRYLRENVAEIDIVAAEPRYGELVYGLRNIDEGFIPELYDESVLTSRFSVGPYDAVRRTRELVLEEGIFAGISTGAILHAALGVGNKALRAGERADIAFVVADGGWKYLSTGAYDGTLEEAEERLEGQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Y8</accession>
    <name>A0A231H1Y8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Respiratory nitrate reductase 2 beta chain</fullName>
            <ecNumber evidence="3">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">narY_1</name>
        <name evidence="3" type="ORF">B7C42_05194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42856">
        <property type="protein sequence ID" value="OXR42856"/>
        <property type="gene ID" value="B7C42_05194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="567" mass="62255" checksum="E7DBA2CCDBCBBC10" modified="2017-10-25" version="1">MRVMAQLAMVMNLDKCIGCHTCSVTCKQAWTNRGGTEYVWFNNVETRPGQGYPRQYQDQEKWKGGWTLNRRGRLTLKSGSRMKRLLNIFANPDLPTVSDYYDPWSYDYDTLLSAPAVDTTPVARPKSLITGEDTKVTWGANWDDDLGSGPEQVGRDPLLARLSDQVKLEFEQTFMFYLPRICEHCLNPSCGASCPSGAIYKRAEDGIVLVDQDKCRGWRQCITGCPYKKIYFNHKTGKAEKCTFCYPRVEVGIPTVCSETCVGRLRYIGVMLYDADAVLEAASVTDPEQLYPSQLAVFLNPHDPRVITEAERAGISPEWIAAAQDSPVYKLIVDYKIALPLHPEYRTMPMVWYVPPLSPVVDVLAETGHDGEDAGNLFGAIDSLRIPVEYLAELFTAGDIGPVRAALQRLAGMRSFMRSINLGQEPDLTIPGAVGLEPEEIEAMYRLLAIAKYEHRYVIPSGATSRAHELDSLATGCSLDGDGGPGMTAFDVTSEKFALVDANSAAPEQKSSRINLLNWDGGSTEGLVPERDGTGAANGHSETNGHAGGPAHDVADDTLPEPTGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2S5</accession>
    <name>A0A231H2S5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43149">
        <property type="protein sequence ID" value="OXR43149"/>
        <property type="gene ID" value="B7C42_04571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019919">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03617">
        <property type="entry name" value="F420_MSMEG_2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="40341" checksum="CBD50588125FC029" modified="2017-10-25" version="1">MLVDGNIGGSIDGTGGGDLNAVGEQVDFADRLGYDGVWSTEVARDPFLPLLAAAQRSPRLQLGTAVAVAFARNPMTTATVANDLHAFSSGRFMLGLGSQIQAHIERRFSMPWSAPADRMREFISAVRAIWHSWEADERLDFRGEFYRHTLMTPMFRPERNPWGTPPILLAAVGPKMTRVAAEVADGIVLHGFTTERYLREVTIPLLEAGLRASGRDHARFTTSYPGLVVTGADERDFDRALDAVRRQIAFYGATPSYRPVLELHGWGELGTELHRLSKSGDWQTMTHLVDDTVLETFAVVGEPDTIGAQIHRRFAGIIDRFTLYTPYPMADAVRYTIIDDLHESVTACPRSEAGAQPTADSYSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3E5</accession>
    <name>A0A231H3E5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YgaV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygaV</name>
        <name evidence="2" type="ORF">B7C42_04236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43369">
        <property type="protein sequence ID" value="OXR43369"/>
        <property type="gene ID" value="B7C42_04236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="119" mass="12146" checksum="63BB11805CFDCA37" modified="2017-10-25" version="1">MPKALPVIDMSAPVCCAPVAAGPVDDVAALEVALRLKALADPARVKLMSLLLASPDSGENGGDLAAAVGLTESTVSHHLGQLRKAGLVESGRVGMTVVHRAKRDALAALCVVLDPNCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3G3</accession>
    <name>A0A231H3G3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenical resistance operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsR</name>
        <name evidence="2" type="ORF">B7C42_04234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43367">
        <property type="protein sequence ID" value="OXR43367"/>
        <property type="gene ID" value="B7C42_04234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="13059" checksum="18F4B30CC1F57D80" modified="2017-10-25" version="1">MSNQELPSAAMAGCVTTPRVRPVVGAEAAHDLAAMFKALGDPVRLRVLSAIAARAGGEACVCDISDGLDVTQPTISHHLKVLREAGLVTGERRASWVYYRVIREALQRLSDLLADQAGLGVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3I1</accession>
    <name>A0A231H3I1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779326.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43429">
        <property type="protein sequence ID" value="OXR43429"/>
        <property type="gene ID" value="B7C42_04296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="18163" checksum="8E16C3BC2D782C62" modified="2017-10-25" version="1">MNDLDAMLAEIHRSDTHLGKLLIRTADRHRTDHEVHHVCRDLLVWTDEHRRKLARTGERRGLRLDASPLSAAGPVESARRTLGTLVGRRHAPALLLLRDLRTLHSHAAVVSVNWEILAQAAQAARDSELLDLATDCHPETLRQMRWANAKIKETAPQAVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3I2</accession>
    <name>A0A231H3I2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribitol 2-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbtD</name>
        <name evidence="1" type="ORF">B7C42_04274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.56" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43407">
        <property type="protein sequence ID" value="OXR43407"/>
        <property type="gene ID" value="B7C42_04274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050255">
        <property type="term" value="F:ribitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="27312" checksum="1021001CA6C17ABB" modified="2017-10-25" version="1">MTDTPPLALVTGASSGIGFELARQFAERGYDVVIAAEDAAIDVAAESLRRSGARVRPLRIDLHSANGPEQLYATATEDGRALDAVAFNAGIGRGGDFLSTDLDDELAVIDLNVRSTVRLAKPVVADMAARGSGRLLFTSSIAAMIPGPEQAVYHASKSFVQSFAEALRQELRDKGITVTALMPGPTDTDFFRRAKMLDTRIGRGPKDDPAEVARQGVDALLAGEQKVVATSLPTKVMGLVGRIVPDALKAKAGQIISGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3L3</accession>
    <name>A0A231H3L3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetyltransferase OatA</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">oatA_1</name>
        <name evidence="4" type="ORF">B7C42_04301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43434">
        <property type="protein sequence ID" value="OXR43434"/>
        <property type="gene ID" value="B7C42_04301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="38"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="484"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="710" mass="76261" checksum="FD487673A0B2B25E" modified="2017-10-25" version="1">MVTGGIARARIAAPPRPAPVRSASGRAETASRRTAYRGDLDGLRGVAIVLVVVFHIWFGRVSGGVDVFLVLSGFFFTGLLVRRAERGAVGIAFTVRRTGRRLLPAMVVVLAAVVAATISTRPYTQWSDLAGQTLASLFYYQNWRLATSWSDYLAADPSVSPLQHLWSMAVQGQFYLLALVVVAAVAAVLHRIDRIALLRPVLAGLIAPAAVVSLLYATHGAATHQGWNYYDSGARLWELLAGAALALAGPALLLPRMLRAVTALAGLAGVLFCGWLIVDGANRYPGPAALVPVLAAVAVIVSGNNVAAADMPWPNRILSSRPAQWLGEIAYPLYLWHWPILIFYLAESGRPHAGLRDGALVVAASLLLAWATHLLVEQPLRLGARSALLSSSPLYRRGAGTLVCAVAVAVVAATGAWQFGVVRMHPAQPTRPLDRVLYPGAEALAAGAPTPQAPMRPTVLQAPGELPPPTLDGCIADWDTREVVTCTYGDTSATRTLAVVGSSHAEHWVPALEELAAQHSFRIQVYLKMGCPLTLADDATYKGEPIPDCRDWSRAVLDRLAVDRPDWVFTTGSRPRTGTGDETPPEYVDVWSALAERGLDTVTIRDSPWLRHNEIRYAAADCLAGGGDPVSCGMRRSDALDPVDPQLEPASRYPNIFPIDLSDAFCDASVCPVVAGNILIYHDEHHLTSSYSRSLSGPLGRELGPLLHWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3R7</accession>
    <name>A0A231H3R7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502785.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43517">
        <property type="protein sequence ID" value="OXR43517"/>
        <property type="gene ID" value="B7C42_04385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="10438" checksum="3B3D528D151EE0D3" modified="2017-10-25" version="1">MSDLTADQSAISAFGATHQSIGTEIAGAADMDTATHVAAMTPVFGLIGADYLAMFAAAQVLHCSDVNDLSAKCNHLGQSAFGTVAILGDNDAAAAGALGAIGNAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3S2</accession>
    <name>A0A231H3S2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crt_8</name>
        <name evidence="2" type="ORF">B7C42_04253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43386">
        <property type="protein sequence ID" value="OXR43386"/>
        <property type="gene ID" value="B7C42_04253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="30727" checksum="18E2E0A66EFD8F42" modified="2017-10-25" version="1">MLSDMADIRWEISDSIATVTLDRPQQLNAFTTAMGAELIAAFDEFDRDDRVRAIIVTGAGRAFCAGADLSAGAETFAAEATDTFRDGGGEVALRMFESQKPIIAAINGPAVGVGITMTLAADFRLAADSARIGFVFNRRGIVPESCSSWFLPRLVPLQTALDWVYSGRLVEADEALDAGLFYALHPVGDLLDQARALARRLTEHSAPVSVALSRQMLWRGLGADHPMISHRVESRGINQRGASADAREGVSAFLEKRPAHFPDSVERDLPDVFAGDLATPPFRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Y0</accession>
    <name>A0A231H3Y0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative epoxidase LasC</fullName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43446">
        <property type="protein sequence ID" value="OXR43446"/>
        <property type="gene ID" value="B7C42_04313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="476" mass="50780" checksum="ADDCD45C7DDA207F" modified="2017-10-25" version="1">MARIGEHAVVVGAGMGGLLAARVLGDHYDRVTVVERDALPEGPEARRGVPQGRHVHGLLPRGKDLLEEFFPGFEAQLRAAGAIDCDVLGEVNFQMAGRTLAQVSTGYRGLQASRPHVEHHVRQRILSIPNVTLRDRSQVSGVITNPFATRVTGVTVHDAGGREDLSADLVVAATGRGGVVPAWLSALGYPRPREEGTTIDIVYRSAFIELEPGALGTDKSLTIGVRELPPRALALFAVEGRNRYVLTLIGHAGEQPPADPDGFLDVAAALAPPDVRAALRRGELLTDIATFRYKANLRRRYERLDRFPSGLLAVGDGLCSFSPVYGQGMTIAAIQMRVLQRCLAAGGERDLARRFYTAVTPEIDIAWQLTVIADSAMPHVGPHPDPVIRVAVAALDPVLAAAERDPVVAATLYRVMGLTQRPSALLRPELVARIGLGAARAAGEAALAEAERRAARIGGLVAALGPARCLAAVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Q8</accession>
    <name>A0A231H4Q8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781168.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43808">
        <property type="protein sequence ID" value="OXR43808"/>
        <property type="gene ID" value="B7C42_04043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="78" mass="8510" checksum="1B54364C4D6BE41F" modified="2017-10-25" version="1">MERVRGAGVNPTERAVLRTLAPGGLLTTAQLQRATAHTTRSIRNALARLQARGLIVPSRDRSRWQLSPRGRAVAATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4R9</accession>
    <name>A0A231H4R9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional NMN adenylyltransferase/Nudix hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43943">
        <property type="protein sequence ID" value="OXR43943"/>
        <property type="gene ID" value="B7C42_04182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="26155" checksum="0F252E55A0A74898" modified="2017-10-25" version="1">MPVMGSGFRLNAAVAVDLVVLTLGARHTANDTLCALLVQRLYAPYRGRWALPGGFVRPEESLSAAAVRELREETGIRGDRMHLEQLATYGEPGRDPRGRVISTAYLALAPNLPAPQAGSQATAAGIWSVEQLLAERGRIAFDHRRILTDGVERARAKLEYTPLATAFCAREFTVAELRRVYEVMWGTDIDPRNFHRKVTTTPGFVLATGATTTRDGGRPAKLYRAGPAQVLHPPMLRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4U2</accession>
    <name>A0A231H4U2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4873 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43736">
        <property type="protein sequence ID" value="OXR43736"/>
        <property type="gene ID" value="B7C42_03971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032371">
        <property type="entry name" value="DUF4873"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16170">
        <property type="entry name" value="DUF4873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4873" evidence="1">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="12000" checksum="94747F229ABFEC9E" modified="2017-10-25" version="1">MRQPEADYQGPAVVVLGDREFAVRVRLRGHRQPIDGIYRWYGRLDPDAALDAAAGNRKQRVEVRTTAGTAAAILGDRDFWGRLRLLGHGAPPYRISTVDDLDARMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H518</accession>
    <name>A0A231H518_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43908">
        <property type="protein sequence ID" value="OXR43908"/>
        <property type="gene ID" value="B7C42_04147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="372" mass="41643" checksum="08E6E24FD2B407DE" modified="2017-10-25" version="1">MKLSDRILNRTLLARQHLLRRSPVPVPQLCEHLVGLQAQDVTPPYVGLWSRISDFDPAAVSAGLEDRSLVRITLMRATIHLVTAADALRIAPHIQPELEKIPFRKGFFYGAMVGLDPEEVRARGEKVLGAQPMSSAELRARAVEEYPDREPTAVTQTWLYQLPVLQTPPRGLWRNNSRPVWSRIEPWLDAPLDDAYPVQELVVRYLRAFGPATTMDVQTWSRLLGIKEILAALGDRVRTYTDERGRVLYDAADAELADPDLPAPVRLLGWYDNVLLSHRDRSRIIPGNAPLPLHHMATQVCPVLVDGFHAGVYKIFADKSVARLRIAPSREWSAREAAEVEAEARALLDFLEPNAQPEVEILAPGANLKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H520</accession>
    <name>A0A231H520_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tycC_3</name>
        <name evidence="10" type="ORF">B7C42_04200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43961">
        <property type="protein sequence ID" value="OXR43961"/>
        <property type="gene ID" value="B7C42_04200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2117"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3181"/>
            <end position="3260"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4266"/>
            <end position="4341"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="5363"/>
            <end position="5438"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="6423"/>
            <end position="6497"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="7964"/>
            <end position="8039"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="9047"/>
            <end position="9123"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="10132"/>
            <end position="10207"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="11217"/>
            <end position="11294"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="12288"/>
            <end position="12363"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="13353"/>
            <end position="13427"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1067"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2152"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="3220"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="4301"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="5398"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="6458"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="7999"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="9083"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="10167"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="11254"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="12323"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="13388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="14660" mass="1575591" checksum="80B2E2597DFECF60" modified="2017-10-25" version="1">[encoded data, 14660 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H530</accession>
    <name>A0A231H530_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43940">
        <property type="protein sequence ID" value="OXR43940"/>
        <property type="gene ID" value="B7C42_04179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="14247" checksum="9F8116892D26CBF2" modified="2017-10-25" version="1">MTAPPARIFDALGDPVRRHILELLAAGEHSAGALVESIRAATPISQPAVSQHLKTLRDTGLVTVRADGTRRYYRLDPDGVEVARTWLTALLDPLHHLANPLDALATEIARGKRTRDSESRVRGAGGEKRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5J0</accession>
    <name>A0A231H5J0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F420H(2)-dependent quinone reductase</fullName>
            <ecNumber evidence="3">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44164">
        <property type="protein sequence ID" value="OXR44164"/>
        <property type="gene ID" value="B7C42_03723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16642" checksum="C983EAB85FCB4E16" modified="2017-10-25" version="1">MPGMPLTGEYAPSPSDWSREQAEKYEASNGTQANTLLDRGIPIILVTSVGAKTGKLRKTPLMRVEHNGEYAAVASLGGAPKHPVWYYNLKANPTVELRDGDVVKDYTAREVTGEEKAVWWERAVAAYPDYADYQKKTTREIPVFVLTPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H685</accession>
    <name>A0A231H685_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777529.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44216">
        <property type="protein sequence ID" value="OXR44216"/>
        <property type="gene ID" value="B7C42_03776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="20759" checksum="291E47EFFCEAE22F" modified="2017-10-25" version="1">MTSTSSLTNSGTKPRATVWRNRALGLLAVIIVLVVAYFVLSAFIPRWWAQRIAGMSGHGSFAQGIWSGLAVGFLCTLIPLLLLLGAVRVWRTRAGKFAAGAAAVLALIVALPNLMTLTIVLGGNSAAHAGERVLDVDAPGFRGASLVGAIVAAAIFVILLVLLLRKQWRARSARRAEAGVVTAPDTANATRPPGDIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6A9</accession>
    <name>A0A231H6A9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775675.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44385">
        <property type="protein sequence ID" value="OXR44385"/>
        <property type="gene ID" value="B7C42_03174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021214">
        <property type="entry name" value="DUF2568"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10823">
        <property type="entry name" value="DUF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="114" mass="11769" checksum="7334CE6E9FBC7CE7" modified="2017-10-25" version="1">MQELWKWANLTVAFAVELGALVVLGLWGWRAGDSTVVKVVLALGIPLAAAVAWGMFAAPKASFDIPLLAVITKVVVFGGAAAALWGLGHRVAAVVFAGLVIANLLAIKVGHLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6B3</accession>
    <name>A0A231H6B3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folK</name>
        <name evidence="9" type="ORF">B7C42_03200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44411">
        <property type="protein sequence ID" value="OXR44411"/>
        <property type="gene ID" value="B7C42_03200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19540" checksum="B5557631ECBE794B" modified="2017-10-25" version="1">MSRAVLSIGSNLGDRLAHLRSVVEALTPQLVAVSPVYTTAPWGGVPQEDYLNAVVVVEDSELGPHDWLERGQRLEQRSGRVREIRWGARTLDVDVIWCAERGAAGLRPVTSADPELTLPHPQAHNRAFVLVPWAEVEPDATLEVDGRTCRIRDLLAELDPGEIDGVRLTDLSLSAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6G1</accession>
    <name>A0A231H6G1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44461">
        <property type="protein sequence ID" value="OXR44461"/>
        <property type="gene ID" value="B7C42_03250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="23667" checksum="B4B95FE516B52838" modified="2017-10-25" version="1">MTMSTPRPVEQPSATHLGTNVRHPADDARAADRRGLIVGTAIDLIAREGLRALTHRALDTAAGLPPGSTSYYFRTKRALIEAIVDVITERSRTDFRSAGLPATDPDDIATAVAAWLDDLLARRRNHLIARHMLITDLLGDDELHSRLVASLFSHRHARELFRSLGAADPDTAAADYIAVIEGLVFDRFAGARRESAAGNSESAAQLARPLRAVLHAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6M0</accession>
    <name>A0A231H6M0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ftsH_2</name>
        <name evidence="5" type="synonym">ftsH</name>
        <name evidence="9" type="ORF">B7C42_03196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44407">
        <property type="protein sequence ID" value="OXR44407"/>
        <property type="gene ID" value="B7C42_03196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="200"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="796" mass="86073" checksum="086EC4F5BF2F138D" modified="2017-10-25" version="1">MNRKTVFRNLAIVAGILLVIYLVSYFSNDTRGWKNVDTSVALTQLADKQNVKQVQIDDKEQQLRITLKQGNDATGGQTQIMAKYPGGSEVSAQILRDVQQSGAPFNTAVKQDSWFTQVLLFVLPMVILLGLFVFVMARMQGGGRGGMMGFGKSKAKQLSKDMPKTTFADVAGADEAVEELYEIKDFLQNPARYQALGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFDQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGDRTGVIIIAATNRPDILDPALLRPGRFDRQIPVGNPDLAGRRAILRVHSQGKPIAPDADLDGLAKRTVGMSGADLANVINEAALLTAREHGNVITGPALEESVDRVIGGPRRKSRIISEHEKKITAYHEGGHTLAAWAMPDIEPVYKVTILARGRTGGHAMTVPEDDKGLMTRSEMIARLVMAMGGRAAEELVFHEPTTGASSDIDQATKIARAMVTEYGMSARLGAVRYGQEQGDPFLGRTMGTGSDYSHEVAREIDEEVRNLIEAAHTEAWAILNEYRDELDALATALLERETLHRKDLEQVLATVDKRPRITAFNDFGERVPSDRPPVKTPRELAAERGEPWPEEAETRKPSQPAPQPVPANGYPQEGHRNPAPAPTPGYGYPAPQPGNYPRPANGPGYPPRQGTHGSRPDYGAPAGWSAPGWPPQEDPSAGGSPQQPEYGGGYGGGSQGYGEPQRYGGGHRRPEWSGDQEGSTQNGTQDHGDWDGPNSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6U3</accession>
    <name>A0A231H6U3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding/permease protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cydD</name>
        <name evidence="11" type="ORF">B7C42_03391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44601">
        <property type="protein sequence ID" value="OXR44601"/>
        <property type="gene ID" value="B7C42_03391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="385"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="417"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR44601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="746" mass="77949" checksum="86B04A1E70722349" modified="2017-10-25" version="1">MARPVDPRLWRHARSARRYLIISVGLSLVITAGIVVAALMLARVAAGVITDPGRRTVGAWTAELAILAAAIAVRTLATWWQSRLAHRAGAQVVAELENSVLAAGAALPPRDLESQRTELAVVVGDGLGGLRAYLTGYLPALLLAVLVPPIVLAVIAVHDLTAAIIILVTLPLIPIFMILIGLMTQGRAADALAATTRLSEQMLDLFAGMPTLRALGRETAAAEGDSPTMRHRVRDLGEALHKRTMATLRMAFLSSMVLEMLATLCVALVAVSIGMRLVFGHMGLYAGLLGLILAPEVYLPLRAVGERFHAAQDGMAAAERAFAVLDPDRPEPRNLSAAVPGTRDVPVAAPTRTGTSRADDRSARRSGGPPALRVPGWRGPGTGDVELRDVWVCARGGYAPAGLSGVLRPAAVTALIGPNGSGKSTALQAVLGLMSPERGAVLVGGRPVGELDPDEWWSHIAWLPQRPVLLPGTLRENLELFGARAGAAGRGDGGDEAARRAEAVDKACAATGFDAVLAELPDGWDTVVGPGGLGLSLGQRQRLALVRVLAADRPILLFDEPTAHLDERSEATVLAALTERARAGATVVVVAHRPSVLAIADHIIEVHARTESNPAEHPAAQRESAGLGLRRAQPPIDGAGGSRAYDDVEEGLTHRAVGWTRRTGDGFPVDSELPGGEDRHSETPGTEGQDSACPGPGTSRTDGVPEHVAPAAADRVGEVRRGDAHASGTPVAPIGSAPTRTGEWMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6X0</accession>
    <name>A0A231H6X0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain type dehydrogenase/reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497707.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44542">
        <property type="protein sequence ID" value="OXR44542"/>
        <property type="gene ID" value="B7C42_03331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="31176" checksum="0055C8E78ABD5BD0" modified="2017-10-25" version="1">MSESSNQPGTDLSGKVAIVTGAGAGLGRAEALALAGAGASVVVNDLAESDAVAATLADIRALGAKAEFVGGSVAERATADALIRTADETFGGVDIVVNNAGIVRDRMLFNLSDEDWDAVLAVHLRGHFLLSRNAAAYWRGKSKESGAPIYGRLINTSSEAGLLGPEGQPNYAAAKAGITALTLSASRGLSRYGVRANAICPRARTAMTESVFSAAPEGDVDPLAPEHVARLVAYLASPGADAINGQVFVVYGPMVALMAAPEVEARFDAAGAEWSADALADTLGTYFAERPAGRTFSASSLHDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H754</accession>
    <name>A0A231H754_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776263.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44711">
        <property type="protein sequence ID" value="OXR44711"/>
        <property type="gene ID" value="B7C42_03505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="18276" checksum="777E59F865A0543E" modified="2017-10-25" version="1">MSSEADRAAAHQRRRLTVDVKNALRDLNIQLALLNRRFGGRVELRDVDWTCLDLINRQGPISPTALARRTGLHPATLTGVLDRLQKGGWIVRERDPEASDRRAVTLRAVRERNAELFHVFSGMNRRMDELLERYSEPELEVIADFLRQTGTAGSDSASELGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H782</accession>
    <name>A0A231H782_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicyloyl-CoA 5-hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.209</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdgC_1</name>
        <name evidence="2" type="ORF">B7C42_03513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.209" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44719">
        <property type="protein sequence ID" value="OXR44719"/>
        <property type="gene ID" value="B7C42_03513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="128"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="401" mass="45254" checksum="C24A95C2CB93D8C7" modified="2017-10-25" version="1">MRIVCIGGGPAGLYFAISMKRRDPAHAITVIDRDPPGSTYGWGVVYWDDLLDILYRNDPDSAQAVRAGSVLWREQAIHVGDERTAYFPGYGFSMGRAALLDVLSRRAVELGVDVRYGREVHDLSGFDDADLILASDGANSRVRQLDDHRFGTSVTLGENRYIWLGTDKVFTRFTFAFEHTPAGWIWFHAYPSIAGRISTCIVECQPQTWHGLGFDSPDTAANMSVLESIFTRVLDGHSLISKSRGENARWSCFPEVANKSWYHDNVVLLGDAAHTTHFTIGSGTRLAIIDAIVLAQSLYEHGEIADALEDYDAQRRAAMRPIQAAARTSMTWFERADRYLDRDAVQFAYAMAVRHGLQMPWRYQMHLLMQIPAARRSRRVVDSGRRWWRAARRGELAMGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7C8</accession>
    <name>A0A231H7C8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44759">
        <property type="protein sequence ID" value="OXR44759"/>
        <property type="gene ID" value="B7C42_02713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="43564" checksum="8B99BA56AACA62A4" modified="2017-10-25" version="1">MSESFERIPVILHSEEQPAVRETYGFTGGHGIVLEGQLLRPPGDRRSGATVFLFQHPTSTLNLLPMPTALAARGHHVLCGASRYPKNDAALVMEKVVLDLGAWVRWAREVAGYDRVVLVGWSGGGSLSLLYQAEAWDPSITHTPAGDPVDVVGAGLSPADGVVFIAAHLSRAETLTEWLDPSVIDETDPHRRDATWDIYADDAPHRPPYDPEYVAGFREAQRARNRRISDWALTRLADLRAAGGPEQEQPFLVHRTMCDVRWLDPAVDPNDRRPNWCYLGDPRTANVGPVGLARYTTLRSWLSQWSLDHSVAGGARNAARITKGPVLQIENSADDAVPATHNPIVRDALATPDRTYRVIPGATHYYVGQPGHLRTCLEYVEQWAAEHELIAARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7N8</accession>
    <name>A0A231H7N8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44802">
        <property type="protein sequence ID" value="OXR44802"/>
        <property type="gene ID" value="B7C42_02756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="15272" checksum="EE19A8B4CF6005EB" modified="2017-10-25" version="1">MNAIQQAYDAVQRSWTGQQWDAWAATCARDYEFDTGTGLRLDLAGTLDWSRAWFTAFPDYAEDIRALHPAPNSAVAELVGRATAVNDFVVAGVTVLPATGRRFEIAYAKVLVFDADAKVVRDRQYLDTAALLRQFGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H852</accession>
    <name>A0A231H852_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784187.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44927">
        <property type="protein sequence ID" value="OXR44927"/>
        <property type="gene ID" value="B7C42_02883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10174" checksum="D243AB3DC781DECB" modified="2017-10-25" version="1">METIKLVLESVWKILLVGIVLGAGLPALFAVGVRGLAVANGHESADETVHRPNPFGAAVAVVVFAVVVAAIAVGITIIVASGFGKAVSFEHIYPTLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H870</accession>
    <name>A0A231H870_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein NrdI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nrdI</name>
        <name evidence="5" type="ORF">B7C42_03006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Probably involved in ribonucleotide reductase function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NrdI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042917.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45049">
        <property type="protein sequence ID" value="OXR45049"/>
        <property type="gene ID" value="B7C42_03006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00128">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020852">
        <property type="entry name" value="RNR_Ib_NrdI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004465">
        <property type="entry name" value="RNR_NrdI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37297">
        <property type="entry name" value="PTHR37297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07972">
        <property type="entry name" value="Flavodoxin_NdrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005087">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00333">
        <property type="entry name" value="nrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18558" checksum="521534FAB4594BFE" modified="2017-10-25" version="1">MAGLSGEGTQSTPALVYFSSASENTHRFVERLGLPAVRIPLRTADSLRVDTPYVLICPTYGGGRHVFDAQRGEGAAGRSDKEFVPRQVAKFLNDPHNRALLRGVIAAGNTNFGDTYCYAGEVISRKCGVPYLYRFELMGTAEDVERVREGLGLFWQRQQHRPERRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H876</accession>
    <name>A0A231H876_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lutA_2</name>
        <name evidence="2" type="ORF">B7C42_02949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44992">
        <property type="protein sequence ID" value="OXR44992"/>
        <property type="gene ID" value="B7C42_02949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="27526" checksum="42441C5584F9AE51" modified="2017-10-25" version="1">MSARTALFITCVNDVMYPGTGRAAVALLRRLGVEVDFPMAQSCCGQMHANTGYRADTAKMAWHFVSVFGDYDRIVVPSASCGAAPGEFYRVVAEQVGDAALAREAEALVPRIRELTEFLTDDLGVVDVGAYFPHRVTYHPTCHSLRVQRIGDRPYRLLRAVAGLDLVDLPAADECCGFGGTFSVKNAAASGAMNADKAAHVRETGASVVTAVDNSCLMNIGGRLAADATAVRDLHLVEILARTTADGPMPGLPVVAGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8A2</accession>
    <name>A0A231H8A2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein assembly factor BamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bamB</name>
        <name evidence="2" type="ORF">B7C42_02987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45030">
        <property type="protein sequence ID" value="OXR45030"/>
        <property type="gene ID" value="B7C42_02987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="469" mass="48863" checksum="2293F044B159389A" modified="2017-10-25" version="1">MRSGSRRPERSEHDRGGHHPTILRHSVIRGGAPRRVIAAVGTLGLLMLTGCGSSTVDDIKVGSGKGWQSAFHDARNSGASSVTGARHLSLSWSRPIGGPLANATTIGPDGQLFVTSRATTDCVGKPGTTGMIFSFQMPTGRKRFCNALGPDAVAAASAVDGASNVYVGDDGAVFSFNPLGQPRWRTPVAGVPVSVQFTHDGTVLSVSQSGQVDVLDRQTGDREVSTYQVLGDPDFLAHPNVTRPPDGQGIDDCAVGGPQCAVANVSALDPNSGRFYLTAWRTGAPTASLVALHYADKKVTQDWSVDILTDGSATSPALSADGKTLYVGDNSGRLLAVDTADGHTKWTQPLGFAPRGGISLLDGLLIPAGDDGHLMALRDNGDRVEIAWERKDLTLRGRPVQTAGDTGYVVVPMGEALHLLTFDTKSGKTIASAPLPGAQGTTVSTAIGPDGQVVVGTRIGELFAFTPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8S5</accession>
    <name>A0A231H8S5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">arlS</name>
        <name evidence="11" type="ORF">B7C42_02384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45259">
        <property type="protein sequence ID" value="OXR45259"/>
        <property type="gene ID" value="B7C42_02384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012940678" description="Histidine kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="217"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="436" mass="46382" checksum="E5C9DDBC70698882" modified="2017-10-25" version="1">MRRRILLSMLAALILTTVVLGIPLAFTAWQWVADITRSDLRARLDRMSVEIVGQERDDGLVHGVLDLRSVRPLIPAGGRLTIIYPTPEDAALRVDAGAPEVENPVVESLSMGTSGSLRLEVPAAPMHSMQRQAVGAVALVALASLAAGAAVAVVTARRVADPLRDVAARAARLAKGDFRPDPRRHGITELDRVSDVLDSATVEIAGRLQREHALVADVSHQLRSRLTAVRLRLDELSAHPDPAVVQESEEAMAQVDRLTEAIDELVRDSRDQDAADHEPVPVVAELRGVVAEWRHPFAEAGRKLVLSGDPGLRAPVTGSRLREAVAVLVDNALVHGGGDCSVSVRTVYGGPDREPLVAVEVADEGEGVSDELAPHIFDRGFSGAGSTGVGLALARALIEADGGRLELQRRRPALFAVFLGKPTAGRSGNGVIGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8T1</accession>
    <name>A0A231H8T1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system</fullName>
            <ecNumber evidence="2">2.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acoC_1</name>
        <name evidence="2" type="ORF">B7C42_03093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45136">
        <property type="protein sequence ID" value="OXR45136"/>
        <property type="gene ID" value="B7C42_03093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="29044" checksum="454A861F0E1AFAE7" modified="2017-10-25" version="1">MNTSVRIAHRMSAAGIAYTRMGRGEPLLLIHGIGSSRHTWRTVMIDVAREREVIAVDLPGFGLSRPGSSTVSSCADALAGLIKELELTAPHVVGHSFGGAIALELGRRGVARTVVAFAPIGFWGAPGVVWAQMALRATYTMSRSLRWALPLLAKTRIGRTAAAGLFYGRPDAIPPSQIIEDAEIFSGATAFSDVCEGFGDYVFTVPDKLCDIPVTIVWGTRDRLLPAGSQARRARSALPNAQHVCLDGVGHAAVSEDATSSRLLVSDRWDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H903</accession>
    <name>A0A231H903_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45345">
        <property type="protein sequence ID" value="OXR45345"/>
        <property type="gene ID" value="B7C42_02470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="14285" checksum="9CC4925A149AA4AB" modified="2017-10-25" version="1">MRELHPDVRVAMAMGRELKHRIAEMRERADGIVARRPSPSGMVIPEVNVYGQLTDLYLAPGTCDRFGNEELVAEIVAAIRESTVNARRQYGIAMNEDHHHVPLAEKARQWRAEMDAPKPSTTGNPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H977</accession>
    <name>A0A231H977_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776602.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45408">
        <property type="protein sequence ID" value="OXR45408"/>
        <property type="gene ID" value="B7C42_02533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="12598" checksum="FB0462C5D21CAC79" modified="2017-10-25" version="1">MDLARHLEEVMYEHNRWLRNHNEDFEEAQRRLAANGAHLAAEIDRGIVEAERLAAAEAEERERQEEEAREQREAIARAAAARKANQAVAPIDDEDEDDAYYRRKSWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9R8</accession>
    <name>A0A231H9R8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783953.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45581">
        <property type="protein sequence ID" value="OXR45581"/>
        <property type="gene ID" value="B7C42_01873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="78" mass="8751" checksum="EA34D2BD21966A7E" modified="2017-10-25" version="1">MIELAMEQMEDIPLSHEKAELEKDIDAMMATASPNRRWEFPSDGLVADGVEAVREHYRRALSGALSRGMANDGKYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA89</accession>
    <name>A0A231HA89_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042510.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45749">
        <property type="protein sequence ID" value="OXR45749"/>
        <property type="gene ID" value="B7C42_02041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="16453" checksum="AD078DFBF8E897DF" modified="2017-10-25" version="1">MTYHDDPFAPALNTAHTWLRTVADRLATEDRTFALRALRAWLHTVRDRLDVPVAAHFSAQLPELLRGIFYEGWVPAHVPVHHDVASFVDAFAHEAGVSADEAVALIGAVTIALSDVFSPGHLDHVLAVVPEPLRAVLLGSELNGTAATVPGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC9</accession>
    <name>A0A231HAC9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-ketosteroid-9-alpha-hydroxylase reductase subunit</fullName>
            <ecNumber evidence="8">1.17.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hmp_3</name>
        <name evidence="8" type="ORF">B7C42_01979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45687">
        <property type="protein sequence ID" value="OXR45687"/>
        <property type="gene ID" value="B7C42_01979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="260"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="348" mass="37089" checksum="5669C515F240E6F2" modified="2017-10-25" version="1">MASPPMFRPATVTRIVKECADARTFVLAPHDGPLTYRAGQFCTFRVRVNGTELYRSYSMSSAPETDAELMTTVKRVPGGKVSNWLLDNVSEGDEIDMGRPAGRFCLRDTEVPLLGFSGGSGITPVLSLAKSALATTARQVRLLCADRDADSVIFGTTLLELAERYRGRLQVVRHLDNAAGLLHPAAVREFVGADGHADSYVCGPEKFMEMVEGALPGPGMIFSERFGAPVPELADSAIAPVPVTSPETATPATESGTAGGTVTIFLNRKKATVPRHAGETLLESARRAGLTPPFSCESGNCATCMARLSEGSATMRVNDALADDEVEDGYVLTCQAVPDTESVTVHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAF3</accession>
    <name>A0A231HAF3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator TtgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ttgR_1</name>
        <name evidence="6" type="ORF">B7C42_02097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45805">
        <property type="protein sequence ID" value="OXR45805"/>
        <property type="gene ID" value="B7C42_02097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="23277" checksum="EBCDA661CD6948AE" modified="2017-10-25" version="1">MSGQRRPANVRAYDTLLAKGEERKLRILAVAQRMLARNGWRSTTLAQIAREAGVTPAGLLHHFESKDQLLHAVLEARDTDDEMHADLEGELPEQISGVADRFHRAPDLIGMYAVLLIENLEPDAPLHDRLLDRYRAATDQVAESIRRGQRCGRYSADVDPAVKAVEIVAFLNGMETSWLLDPSIPLTTVFQEYARSLERELTRSDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAS9</accession>
    <name>A0A231HAS9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator YiaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yiaJ_1</name>
        <name evidence="5" type="ORF">B7C42_02251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778017.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45958">
        <property type="protein sequence ID" value="OXR45958"/>
        <property type="gene ID" value="B7C42_02251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="27489" checksum="78C095A0D4D48F1E" modified="2017-10-25" version="1">MAATDEPRSGARAVDRAIAVLNCFDGDDPELSVSELAQQTGLPVSTTHRLLQALVRGRLLEQDHANDRYRIGHGLASLARPALTRLGLDSAAPHLYALAANIRISVSLSVPDSRDALTVFQARPPVSFCPNQIPRPRRPLRSSAAGHALLAFSPGDRLIETYAGRHESDPPASADLDRVRRAGFAVEVIDSDDPIRSIAVPIVGRGRQVRGALCVQARSARLDADLMRSILPPMRHVANRIGPLLHAEPDAADTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAX7</accession>
    <name>A0A231HAX7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-chlorobenzoyl coenzyme A dehalogenase-1</fullName>
            <ecNumber evidence="3">3.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fcbB1_2</name>
        <name evidence="3" type="ORF">B7C42_02301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR46008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46008">
        <property type="protein sequence ID" value="OXR46008"/>
        <property type="gene ID" value="B7C42_02301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018787">
        <property type="term" value="F:4-chlorobenzoyl-CoA dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009188">
        <property type="entry name" value="NiFe-hyd_mat_HypX/HoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006787">
        <property type="entry name" value="Hydrgn_mat_HoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="55"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="2">
        <location>
            <begin position="191"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="581" mass="63665" checksum="787C52C53E9DFAB4" modified="2017-10-25" version="1">MLRSGHGPTKHPDGGQLVRILLVASAFNSLTQRVHAELRERDHEVGVELALGDDLLRARVARFRPDLILAPMLTTAIPEDVWTEHPVFIVHPGPMGDRGPSSLDWAITEGATRWGVTVLQAVAEMDAGPIWASVGFDVAPCGKSELYRNEVSDAAVEAVLTAVRRFASGDYVPEPLDYDRPDVTGRLRPFLTQQVRRIDWATADTATVIRTLRAADSQPGVLDELFGREYFVHGGHHEDRLRGEPGAVIATRDGAICRATVDGAVWLPQLRPRRVPGGPVTFKMPATDALGADLPAGVPEVPVSPAEAAVRDTWSELRYHEDAGVGYLEFAYPGGAMDTRQCRRLLAAYREACDRPVDVLVLGPRRDFFSNGIHLNVIEAADDPAEESWRNINAIDDVVEAILTTTDKLVIAALAGNAAAGGVMLALAADHVWCRESVVLNPHYRLMGLHGSEYWTYTLPQRVGPEVAAQLTSRTLPVGARAAARVGLVDKVFDGSTERFRAQVRREAEILAAAPELQNLLLAKKQRRAADEAVRPLAQYRAEELAHMHRNFFGDGESYHRLRRDFVANTKPPATPPYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBD2</accession>
    <name>A0A231HBD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46253">
        <property type="protein sequence ID" value="OXR46253"/>
        <property type="gene ID" value="B7C42_01219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="782" mass="82466" checksum="BE820A516B9B4C3C" modified="2017-10-25" version="1">MPTPTKTQVMSWTPGMLSVVAADAGKLRDAIDTQADTMNRTIHGLDWSGAAFQAAGDRADREKTQQRAVATAYDDLSTALQGAENDAGWLIGEIHRVVHNLPHGWSVADDFNITYHDSADKDAVDSTYATLTSLAAQLGQSMDKWAPKIAEAVNAISATAPVSAEKHVVNPADQFTAQQAQADVKAVRDGTADAATLTRLKAATDLAADQKDDLANGRNINLPQFEYLQGLSQAMNGMSGEDIANLGNKLPGTGRDTVQAAIANDLRLVSDPQVHSVGLDGRPGDSVGGMNKLPESIRHDLTSKPGDLATFNGLNALGTLMSKGDTTIQGSDINRAMVKQGAELAAFTDGHAALKDGPLPKVADNFLNDAAGDHAAVHDAIIANPNSSDSDARAAADRMNVTCGNGGKYYGSQHVIDVLQHPWSPSQHGAENMFKWIGQDASLPKGSFANNEAGQTAFGLASILGDSNNQSILNSPDNPIGSKNPALTRTLANSMSPYLGNFVDVHDYPGMNILNSAPVDSSGHLLKSPFRDSADLSKMFAVLDSDPQAARTINSAGMQWHDALEYAAGANTDHAPSLQANAGNLQQAMNAGLTTDINAHAAERSFQASQQYADRGVFADGVTSVVQTAASIGGGPVAGPVVGGIAASVDSYIKADIIPNPADPAHPLPDDKVSTELGSIRDAINSDPIRDEYLQTQGYVQEHPEAASYFDQKDGGNLVADWHNVTAGNGLNEWRDDYSRFEHDTNRHLPNDAFPAPPEDRNGPIAESDVAPRGELRPPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBE4</accession>
    <name>A0A231HBE4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="3">2.3.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fabH_2</name>
        <name evidence="12" type="ORF">B7C42_01097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781437.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46132">
        <property type="protein sequence ID" value="OXR46132"/>
        <property type="gene ID" value="B7C42_01097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="11">
        <location>
            <begin position="116"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="10">
        <location>
            <begin position="253"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR46132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="37071" checksum="E825972A6A2C1F46" modified="2017-10-25" version="1">MVSIAVNEGRKNVAMLGIGAYRPERIVSNADVCEVLDSTPEWIFERTGIRNRRWISGDETLRSMSAAAGERAITNSGIDRTKISALILATSSWLKLTPHGAPSVAFDLGMNGIPAFDLTSGCGGFGYALGVAADLIRAGSAEYVLVIGAETMTVGLDPTDRGTAMIFGDGAGAVVVGPSDVNGISPTVWGSDGESAEAISQDVNFFDYMDRAERLQGTDPEVEPVGRMALRMEGPRVFRWAAVTLPRALSTALEVSGVAKEDIEVFVPHQANARINELMKKNLGLADDIPMANDIENTGNTSAASIPLAMEEMLVTGKAKGGQLALLLGFGAGLSYAGQVVTLPPKPIEPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBE8</accession>
    <name>A0A231HBE8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent curcumin reductase</fullName>
            <ecNumber evidence="2">1.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">curA_1</name>
        <name evidence="2" type="ORF">B7C42_01143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46178">
        <property type="protein sequence ID" value="OXR46178"/>
        <property type="gene ID" value="B7C42_01143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="40"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="363" mass="38810" checksum="117937F4731E0FA3" modified="2017-10-25" version="1">MSCAVAWAEKGSSGRRRAIYYRPVADAVNRQWVLRRRPLGALRDEDFELRDVPVPVPGRGEALIRVHWLGIDPTQRGWLNESDNYIDAVPIGAVMRGSGVGQVVRSNDPDFPVGSWVAGMVGWQDYVVRSAGGLFGLNLVPDGVPPTSMLSLFGPPGLTAYFGMTDIGRPEPGQTVLVSAAAGITGSIAGQIAKALGCKVIGIAGGPEKCSWVIEHAGLDAAVDYKHEDIDARLTHLAPNGVDVFFDGVGGRILEYGLAHLAPRARVVLAGAISSGYQGADPPLGPRNYMRLALDRARMEGFIFLDYLDRFPEAFTALHGWQAQGAITIAETVSRGLESAPSALRAVFEGRNLGKQLVEVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBW4</accession>
    <name>A0A231HBW4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="3">5.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ino1</name>
        <name evidence="3" type="ORF">B7C42_01291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781616.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46325">
        <property type="protein sequence ID" value="OXR46325"/>
        <property type="gene ID" value="B7C42_01291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017815">
        <property type="entry name" value="Myo-inos-1-P_Synthase_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03450">
        <property type="entry name" value="mycothiol_INO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="197"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="363" mass="39324" checksum="0534B9D1AC23EFD6" modified="2017-10-25" version="1">MSDVNPAAEIRVAIVGVGNCASSLVQGVQYYKDADENSTVPGLMHVKFGQYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKISDVPPTGVTVQRGPTLDGIGKYYAQTIELSEAEPVDVVQALKDAEVDVLVSYLPVGSEDADKFYAQCAIDANVAFVNALPVFIASDPAWAQKFVDAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVQLDRTMQLNVGGNMDFKNMLERERLESKKISKTQAVTSNLKKELGANDVHIGPSDHVGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGIIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPKQLADDVARTQLEAFIIGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBZ7</accession>
    <name>A0A231HBZ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator MalT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">malT_2</name>
        <name evidence="3" type="ORF">B7C42_01432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46463">
        <property type="protein sequence ID" value="OXR46463"/>
        <property type="gene ID" value="B7C42_01432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="786"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="853" mass="91077" checksum="BF426726732D8C37" modified="2017-10-25" version="1">MPELSFVPLSLPAAHARIDEAAATGAGQAVLICAPAGTGKTVLAADWVTRLTTRHSDCRVGWLTFTGRRGESADLWRAIAGVLDLPAGSPDRDPTGPLAEPATLVDRLTERAEPTVLVLDDAHLLTDPLALAGLEYVVENAPPTLTTIVTGRFDPPLRWHGLELSGRLTRLTARELALDNERTAALLGQHDLHLSAADIAGIQRLTCGWAALVRIAAIYLAANPQDRPTALAALARAPHAISDFLVGELLGALPDDALHFLLATAVPEEFSVALATELVGESAPATLEYLLRNNMPITCVARHGELWHSYHPMLRAYLLAEAARTLANRLPRLHRSCSAWFVDARMPSAALHHVLAVPGHPQLSRFIREHGPRLVFGGDGPSFFARLDDVGELADDQFVQLLRIAEAVSRGDVAACTAYLDRLGAEPCSASALVPASWLLALRTAVVADVAVLTGAEPAAPEPATPTPTGHAELDCYIVLQMANAHLHRGDVARAEPGLWQALALAEHAGLRRFVVPAATRLALCGGIGGHLTVMCKRAEHAVELAEKYGLHTHSAMTHAQAMIAYAHYLQGDPIEARGQLPPATTSGLSPAPTADRQALALLRLIEFDSATDRFLAADTLRMQLLDMLAEPAPPRCAGNLVLHTVSALLRIQSRVGAQTLVERAIAVLGHTPEVVLAQACLSEYAQTSSTTLELLQPLLRRTDGLPALTAVTGWLLYAAASDHLDRPVKAYEALAQALHHAADDRIVRPFLEVPGIVALLDGSVGRFGHHDRLVDLIRVHPSARGTAHNPGLTETEMSVLRQLPSGMTTLNIAEGMGVSINTVKTHLRGIYHKLGSGSRAEAIARARELGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCE8</accession>
    <name>A0A231HCE8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YcsE</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycsE</name>
        <name evidence="1" type="ORF">B7C42_01531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46560">
        <property type="protein sequence ID" value="OXR46560"/>
        <property type="gene ID" value="B7C42_01531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="275" mass="29154" checksum="CF65F47465E4279A" modified="2017-10-25" version="1">MTRLPKPKMVATDVDGTLLDEWERVTPRTRTAVAALIADGVPFVLATGRPPRWIDPVIEGLGFPPLCVCGNGAVIYDSAADRILHTSTLDVESLAWIADLAERVLPGCGLAAERVGSSAHDAATPQFVSSPEYEHAWLNPDDTQVSRQEVISAPAIKMLIRLRGTPSAQMQSALEPHLAGRADITYSTNNGLIELSAPGITKAAGLSVVAERLGVDPAAILAFGDMPNDVPMLRMAGHGVAMGNAHPEAQAAADEITASNAEDGVARVLERWWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCF4</accession>
    <name>A0A231HCF4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46633">
        <property type="protein sequence ID" value="OXR46633"/>
        <property type="gene ID" value="B7C42_01607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="25915" checksum="D9D9E11E02D593AC" modified="2017-10-25" version="1">MSAPIVFLDIETTGLHHDRRPWEIGMIRREPDGGQRELTLYISDVDLAHAELIGLNIGRFYERYPMYWTEVGGAFTMDTGIDDDTIVDPDYADQRLKFDEALHPEKRAAVIVERWTRGAHIVGSVPNFDTETLAAMLRRHGLCPSWHYHLIDVEVLAIGHLGAVRRLNPYPIEAADVAAAEFDLTALPWKSDDLSRAVGVEPPGPDERHTAMGDARWAMRMYDRINGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD00</accession>
    <name>A0A231HD00_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041746.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46577">
        <property type="protein sequence ID" value="OXR46577"/>
        <property type="gene ID" value="B7C42_01548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="3">
        <location>
            <begin position="102"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="182" mass="18562" checksum="5A22C3B426845BBE" modified="2017-10-25" version="1">MLRTRPVGERYIAGGKVAGIVVALAATGLLAACGGNDSTASSTPTLKPSHTTATVPAAQSAPNSAPAAPEPSPEQAPATSTANERPEPAQPTSAESAPLSAKDQAYLDELKKRGVNPSSPDIAITAANYVCQSKASGASDQEVKTFVNAMAGTDPSFDPQKMSVEQAGQIYIDVATQSYCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD31</accession>
    <name>A0A231HD31_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Very short patch repair protein</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vsr_2</name>
        <name evidence="7" type="ORF">B7C42_01688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234854">
        <property type="entry name" value="V.Nce30759ORF1689P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46712">
        <property type="protein sequence ID" value="OXR46712"/>
        <property type="gene ID" value="B7C42_01688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="15726" checksum="8E637DC93A1B71BE" modified="2017-10-25" version="1">MSFGRPVTDAVTSARMARQRRTGTAPETALRTELHRRGLRYFVDRAPLPGLRRRADLVFPRRKVAVYVDGCFWHRCPEHATYPKNNAEWWAEKLAGNVARDRDTDARLTAAGWLVVRVWEHENSVAAADRVQSALSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDL9</accession>
    <name>A0A231HDL9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-succinoylsemialdehyde-pyridine dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ald_1</name>
        <name evidence="6" type="ORF">B7C42_00085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.83" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46969">
        <property type="protein sequence ID" value="OXR46969"/>
        <property type="gene ID" value="B7C42_00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="15"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="479" mass="51540" checksum="00B6621C8FFFD5FD" modified="2017-10-25" version="1">MTDHDREEIFIDGTWRRSEGGLLDVHSAITGEVIGRIVDGTANDVHQAVAAARAAFPAWSQTPLEVRLDLLSQLAKKLDERATELTRLISTEVGTPLRVSTAVQVGLPRQVLRSYGDLMDTFVLEEQIGDSLVLREPIGVVAAITAWNYPLQQVLGKVGAALVTGCTVVLKPSQIAPLSAFVVADMIDEIGFPPGVFNLVSGTGRVVGEELVAHPDVDMVTFTGSTGAGRRIGEVAARTVKRVALELGGKSANVILDDADLERAVKVGVANCFTNTGQTCTALTRMLVPRTRLAEVEELVRARLGKYTLGDPLDPETSMGPLASAAQRDNVRRYVRIGIEEGARLIYGGTDELPEGVPPGYFVTPAAFSDVRRDMRIAREEIFGPVLAILPYDSEDEAVDIANFSEYGLAGAVWSQDGDRAMRVARRLRTGAVDINGSFFNMLAPFGGYKQSGNGRELGHHGLAEFYELKSVQQAPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE11</accession>
    <name>A0A231HE11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent stearoyl-CoA 9-desaturase</fullName>
            <ecNumber evidence="2">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">desA3_1</name>
        <name evidence="2" type="ORF">B7C42_00134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47016">
        <property type="protein sequence ID" value="OXR47016"/>
        <property type="gene ID" value="B7C42_00134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="384" mass="43468" checksum="AA55536D1B863771" modified="2017-10-25" version="1">MTILTETENGPLVLSPEQVAEIGRELDALRDRITADLGERDREYIYSIIKAQRGFEIAGRGLMYLGFLPPFWLAGVAALSLSKILDNMEIGHNVMHGQWDWMREPGLNSRVFEWDTVCPADQWKHSHNYMHHTYTNIHGRDRDIGYGVLRIDEGQQWNPYYLGNPVYALALMLLFEWGVMLHDLEADNIVKGKRKWSDIKRLAKGQIRKAGRQVLKDYIVFPLLSGPLFVSTLAGNVTANLVRNVWAYSIIFCGHFPSGVQTFTEEETENETRGEWYVRQMLGSANITGSKLFHILSGNLSHQIEHHLFPDLPANRYPEIAPEVRALCEKYGLPYNTGRLSKQVGSVWLKICKLALPPAIVGKGSQPGVIVMRERQAEPSEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEP0</accession>
    <name>A0A231HEP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase NlhH</fullName>
            <ecNumber evidence="3">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nlhH_1</name>
        <name evidence="3" type="ORF">B7C42_00317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47195">
        <property type="protein sequence ID" value="OXR47195"/>
        <property type="gene ID" value="B7C42_00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="81"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="33955" checksum="30A62C55D52C9B1B" modified="2017-10-25" version="1">MSMTRRTRAVVEAATAAFPKLGTEVLDAAEARRQLAARPPAPIEPIPVAAVRNSTVSSSHGAGIPVRIYTPHGGTEPLPVVMFCHGGGFVICSLDSHDQFCRAMANETGALVVSVDYRQAPEHRFPAAAQDAYAVLRWIGAAVAQHGGDPARIAVAGDSAGGNLAAVTALMARDLGGPGVAAQLLMYPMLDPARASASYRDNARGYFVTDDHLRWYWEQYLGDADGTDPYAAPLLADPAGLPPAHIATAEYDPLRDEGEAYGAHLAAAGVPVEVHRYEGMFHGFMTMGDVLPETGVANARAFAALRRAFAGPARPIFGCADGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEV1</accession>
    <name>A0A231HEV1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47338">
        <property type="protein sequence ID" value="OXR47338"/>
        <property type="gene ID" value="B7C42_00461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015286">
        <property type="entry name" value="Porin_fam_mycobact-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09203">
        <property type="entry name" value="MspA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012805200" evidence="2">
        <location>
            <begin position="33"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="317" mass="31254" checksum="ADD8323F6E47D1E8" modified="2017-10-25" version="1">MRRPLIAAATGIAAVTAVASILWTGGSETSHAQPPGTDVTGSGVHLSASVDNIGVNQPGDRTPNYLMTFSHAAQMSGNFSVNIEGDPITSGQAVAGFLLGCGISVAGGFDVGISPDQGLQLSISPTFTPPSLTTAAAPIATTGSATPTTSGAGASPTTARTTTTPTRAVRTSVVSTTSTTPTTTTTPTTTVTPPTTVVPTTDTPTITTPSLPTTSGSAGLPGVSPPGFDLGPSVGGSLGLSENLDANIGPGQVTTATTATATLDNTTAFPYHIAFNNAALNVSQCASPVAAVPFVSATVSTPTGLVQTTAYGDQFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF87</accession>
    <name>A0A231HF87_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pfkA</name>
        <name evidence="12" type="ORF">B7C42_00509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47386">
        <property type="protein sequence ID" value="OXR47386"/>
        <property type="gene ID" value="B7C42_00509"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="259"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="59"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="35607" checksum="FB57C80EE031B193" modified="2017-10-25" version="1">MNAVIRAVVRTANGRYGDAIVGFQDGWRGLLEDRKIHIHNDDRTDRLLTKGGTMLGTARTNPDVLLEGLGRIKRTLDDNGIDALIPIGGEGTLTAAHWLSDEGVPVVGVPKTIDNDIDCTDTTFGHDTAVSIATDAIDRLHTTAESHQRVMLVEVMGRHAGWIAMNSGIASGAHLTLVPEVPFDVDEVCTMIKRRFQRGDSHFICVVAEGAKPAEGSFHLREGGVDEYGHERFTGVAHQLGVEIERRIGKEVRTTVLGHVQRGGKPTAYDRVLATRFGLHAAEAVHDGRFGQMVALHGTEIGLVSLAEATKQLKLVPNDRHGEAAAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFE6</accession>
    <name>A0A231HFE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative quercetin 2,3-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.24" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47602">
        <property type="protein sequence ID" value="OXR47602"/>
        <property type="gene ID" value="B7C42_00727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008127">
        <property type="term" value="F:quercetin 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="27070" checksum="8606FA501B31E919" modified="2017-10-25" version="1">MATTAVEAVRIVRAGQRYGWRNEWLDSRQSFPATGNFDLAANAHGMLLVHNEDVVEAGAGFDTHQHLNTEIVTWVLEGTVVHQDSAGHSGLIRPGLAQRMSAGTGILHSERNGAVYGERANLHVVQMWIPPDEAGRPPSYQESDVEAGLSHNELVTVASGMPRHRGETAITLGNRYAAFHVARLDPGRSVLVPEAPFGHIFLARGSVVFDGTADGQTTLSAGDAVRTTATGGQRITAVAPSEVLIWEMHASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFH1</accession>
    <name>A0A231HFH1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell wall synthesis protein Wag31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503753.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47476">
        <property type="protein sequence ID" value="OXR47476"/>
        <property type="gene ID" value="B7C42_00601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="27180" checksum="584229D43DCFD505" modified="2017-10-25" version="1">MYRVFEALDELVAIVEEARGIPPTRNCIVPRGEVLELLDDVREALPGELDDAQDVLDHRDKIVSDARNSAEATVTGANDQAEQTVAGAREEADRLLADAKAHADRMVAEARAHADHLVATAQAEADRIVTDGKAEYEALTGRARTESERMIAAGQASYDRSVAEGQAEQERLVSQTEVVRAAHGESARLIDAAQTEADRLREECDQYVDSQLADFEETLHSTLRTVGRGRQQLRSGTGIPDYAADFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFS9</accession>
    <name>A0A231HFS9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="4">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47576">
        <property type="protein sequence ID" value="OXR47576"/>
        <property type="gene ID" value="B7C42_00701"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="35640" checksum="272A6B9A3BBB1E67" modified="2017-10-25" version="1">MTVTTLSTVDADGHAVRSALSDAVGRLDDAIRPVVAYHLGFCDEHGRPVVADGGKSVRSRLTMLAAHAAAGDGLCGIPGAVAVELVHNFSLVHDDLMDRDATRRHRPTVWAVWGDPVAVLAGDAMLSLSHEVLLDSGSPHAMAAARLVGKATRDLIIGQAADVDFEHRNDVGLAECIRMAMGKTAALLSASAAVGGVLAGAPPATVAALQAYGDNIGLAFQLVDDLLGIWGDPAVTGKPVFSDLRSRKKSLPVTWCLESGRPAGQALAQWLAQSGEPSEHDLRAAADMVETAGGRRWARAEARRRVRTAQQALTAVTLTPEYRRELCDLADFIVERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFW8</accession>
    <name>A0A231HFW8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47597">
        <property type="protein sequence ID" value="OXR47597"/>
        <property type="gene ID" value="B7C42_00722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="4913" checksum="D6199C1D957753E5" modified="2017-10-25" version="1">MKRSTLTLITAGMILAGTGAVEILGDGSAGASPPTEHATSATVGGTEVQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG87</accession>
    <name>A0A231HG87_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-[acyl-carrier-protein] desaturase DesA1</fullName>
            <ecNumber evidence="9">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">desA1_1</name>
        <name evidence="9" type="ORF">B7C42_00861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47736">
        <property type="protein sequence ID" value="OXR47736"/>
        <property type="gene ID" value="B7C42_00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="317" mass="35442" checksum="73F85ACBF603DCA1" modified="2017-10-25" version="1">MKVADRDLLRELEPVAERCLADHLRKSRAWHPHDYVPWGEGRNFAALGGNDWAPEQSALPEMARVALVTTLLAEDDLPSCHRVITETCGGDGVWGRWVGCWTAEENRHALVIRDYLVVTRAVDPVALERARMTRLTSGVAAPGAPRLLRGLACVTLLELATRISHRNTGIACGEPIADRMLSRIATDENLHMIFYRNISRAALELAPDAMMRAITEAVTGFRMPGSGRPGFRRHALLLAAHGIYDPAQHLERVVRPVLRNWHVFERTDLTAPGERARDELAVHLATLEKAADRFRERRERVRAREAAFADASAVVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTB2</accession>
    <name>A0A231GTB2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39822">
        <property type="protein sequence ID" value="OXR39822"/>
        <property type="gene ID" value="B7C42_08110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="29935" checksum="2B737511056A6AEE" modified="2017-10-25" version="1">MRYTAPSYTPTRMETVGRKRGRAQLAAAGVPGFMPVERVQTHIAGLLELRLPIASIARDAGVTKKTVLNIHHGAYETVRTRIAVPILRVDFHPNERQGNVLAVGAVRRLRALHALGWTWGRIAARTPGVSQTTISQLARSGTDTVLIAWDTWHAIHTAWEELSGTPATEGRFELARQHARKELWAPPLDWEDLDIDDPRVTVTPSGAASGIGLRERADDRRREVARLTGIGLSAEEIAVRLGITKRHVVRYRQETNTRLCVSSFENESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTI5</accession>
    <name>A0A231GTI5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39934">
        <property type="protein sequence ID" value="OXR39934"/>
        <property type="gene ID" value="B7C42_07997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="56" mass="6275" checksum="B2F328B9BABA8892" modified="2017-10-25" version="1">MSRAPLLLVVAMVGLYALVTSPDLVIGIVIAAAVFVFGLRWLVSTMFRRPRGMWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU34</accession>
    <name>A0A231GU34_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase FadD17</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40088">
        <property type="protein sequence ID" value="OXR40088"/>
        <property type="gene ID" value="B7C42_07843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="430"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="558" mass="60891" checksum="856E3AE23F08233F" modified="2017-10-25" version="1">MTEPSPATADVRRADVATLLLDRLGDERLGLRTRDRDWTWDAVVRESAARAELAHSLRRDGPFHIGVLLDNVPDFVFWLGAAALAGATVAGLNPTRGDAQLAADIRYVDCQLIVTDAAGMARLRELDLDLPDDRCLLVDDPGYAALVDSHRVEPAAAGGPDALMLLLFTSGTTGTSKAVKCSQRRLAMVAYAARDKYGHVRDDVDYCCMPLFHGNAIMALWAPALTVGATVCLTPKFSASQFLPDIRYFGATFFTYVGKALGYLLATPETPRDGDNDLVRGFGTEASVADQAEFRRRFGAELFEGYGSSEGATLAALDPNAPPAALGRPAHAGVAVVNPDTLRECVRAELDEFGRVRNPDEAIGEMIDKAGALAFEGYYKNDAADAERIRNGWYWTGDLGYIDTDGFLYFAGRKGDWIRVDGENTSALMIEQVLRRHPAVIAAAAFGVPDPRSGDQVMAAVEVADPESFDVREFAEFLTAQKDLGTKGTPRLLRVSANLPVTGSNKVLKRQLQEQAWRTDEAVYRWIGRGKPEYEPMTAADKKAWEAEFATYGRERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU67</accession>
    <name>A0A231GU67_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40085">
        <property type="protein sequence ID" value="OXR40085"/>
        <property type="gene ID" value="B7C42_07840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="22114" checksum="E7C7092A454F5002" modified="2017-10-25" version="1">MGAVLGDLLPLAVGVAISPIPIVAAILIILSANAARAGTGFAIGWVLGIVVVTTIFVVLSGTLSDSQDKQSSTVTAWIKIVLGIVLLGLAAMQWRSRSDTGVPGWMRAIDTLSAVGAVGLGALLSAVNPKNLLLCVSAGVAIGTSGIGGGQAVIAVLVFTVIAAASVLVVVIGYLVAAERLREPLDRARRWLQANNHVVMAIVLLVMGAVVLGKGIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUE2</accession>
    <name>A0A231GUE2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40243">
        <property type="protein sequence ID" value="OXR40243"/>
        <property type="gene ID" value="B7C42_07668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="29253" checksum="880FBF0CF498FF23" modified="2017-10-25" version="1">MNRAARPDGPAADDARIQLDVCVPDLWLADDEFDAEAENLRRLEGDEQVLLTLQLGQFSDHDWNPVAQELARYGIAVLTSWIRSRLIFARVKHRTGYQLTMLDGWPDYDTAVDLAHDTVTDALNYFRDKVLKAGKWRAERGASLRTYFIGQCLFQFANHYRSAHTLEIQRRQRELLTDDDTLFGGVQHDVENTIVSRDVLRSARAQMTTVIAQSAVYMQAQGYSIKEIATRFNKSEKQIENMLLYQRKRIRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUG2</accession>
    <name>A0A231GUG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40257">
        <property type="protein sequence ID" value="OXR40257"/>
        <property type="gene ID" value="B7C42_07682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="60" mass="6732" checksum="E34C879AE5600746" modified="2017-10-25" version="1">MSAVRGKPQLVEIDEDLLKAVKAEANRRGMTYRAFFEAALARELKASRKVKTPEQLQLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUV2</accession>
    <name>A0A231GUV2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ssuD_7</name>
        <name evidence="2" type="ORF">B7C42_07552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40386">
        <property type="protein sequence ID" value="OXR40386"/>
        <property type="gene ID" value="B7C42_07552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="42993" checksum="EC60A2054834DE28" modified="2017-10-25" version="1">MTVETSAEPVPATAAPTVEFISLTHTNPSTELEPIPTRGIDLPFVKRYVRTLEDAGFDATLLPYGSSSADSFVLASAVGQLSDTLKPIVAVRPNTVFPTVAAQQLATLDQLTEGRAVLHLISGGNDAEQARQGDYLPKDQRYARTGEFIDVLRRAWTEKESFSYAGEHYRFDDFGPGFPPYGDSIPISFGGQSDAAFAIGAAKADIFAFWGEPLADVKGQIERVHSIAAAAGRTDRPRIWVTFRPIIDRTDDLAWAKARDYVERIARNLDNSPPRKRFTGTPQNVGSQRALEFAQRQEIYDRALWTRTTAVTNAAGASSALVGSPETVAAAILDYIDLGASLVSIRGYDTLNDVIDYGRYVLPLVRQELAHRKATGRRGTLQSEHLGALAAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUY1</accession>
    <name>A0A231GUY1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumarate reductase flavoprotein subunit</fullName>
            <ecNumber evidence="5">1.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ifcA_4</name>
        <name evidence="5" type="ORF">B7C42_07474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778569.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40416">
        <property type="protein sequence ID" value="OXR40416"/>
        <property type="gene ID" value="B7C42_07474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="23"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="490" mass="51636" checksum="5441E34AEAD3F2CF" modified="2017-10-25" version="1">MSDVGSVRPEHAAAIAEWDYEADVVVVGYGVAGASAAIEAARAGADVLVLERTGGWGGAAALSGGFIYLGGGTALQKALGFEDTPENMEKYMTAALGPGVDEAKIHDYCQGSVEHFDWLVAQGVPFKEEFWGEPGWEPPADQGLMYSGGENAAPYNTIATPAPRGHLPQMADKHTGEKGGGYMLMKPLTDMAESLGVRAEYDLRLQRLIVDEAGGVVGVVAKRYGKLVHVRARKGVVLATGSFAYNQDMIEAYTPLLINRPAAAIEEHDGIGIRVAQALGAQLAHMDAIEVAIFADPQVMVRGILVNGRGQRYIPEDSYPSHIGQATLIRQSNEAFLIIDESALEEAQNTVSSAAAMRSQPPTWVADSVEELESDIGFPAGVLQATVEVYNRHAKDGADPLLGKKPEWVKPIGTPLAAYDLRNRTGGFTLGGLKTDLDSRVLHVSGDPIPGLFAAGRCTSGICAGGYASGASLGDGSFFGRRAGRAAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV19</accession>
    <name>A0A231GV19_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-CoA:(R)-benzylsuccinate CoA-transferase subunit BbsF</fullName>
            <ecNumber evidence="1">2.8.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bbsF_3</name>
        <name evidence="1" type="ORF">B7C42_07504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.15" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042662.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40446">
        <property type="protein sequence ID" value="OXR40446"/>
        <property type="gene ID" value="B7C42_07504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033877">
        <property type="term" value="F:succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="423" mass="46303" checksum="B85E9BE6B3B86431" modified="2017-10-25" version="1">MTDAKDVAVQPILSSVRVVDFSMGWAGPVLTQMLADHGAEVVKIESCTHTDWWRTSRALFTEGPEDLDHPWEQSPLFNAVNENKLGVTLDLNQAKGVAVASALIARADIVVENFTPRVMSNLGLDYGTLSADHPELIMVSMPAFGATGPWADFKATAFITESLAGVSSRCGYEDADPMLVSTSFADPNAGIVGALSVLMALRHRRLTGEGQHVEVAQTEALTPHLGGELLDVVMNGAVPARYGNRRPESALCGVYPVRGDDRWIAIDVRDDVQWNALADELGVIDFQRWRTPEARFADRFSIDEVIRNWTVDWDGYELERRLQSIGVPAGRVQNAADLLVDRHLGAVDFYHVMERKYVGAMPYPGPAVRLSRTPAIRKMPAPLLGEHNHFVLGNLLGMSDGAIAELEQEGVIGTEPRFARPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVJ7</accession>
    <name>A0A231GVJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40643">
        <property type="protein sequence ID" value="OXR40643"/>
        <property type="gene ID" value="B7C42_07328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Nterm_IS4" evidence="4">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="3">
        <location>
            <begin position="162"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="552" mass="61500" checksum="5A315EA943B58C25" modified="2017-10-25" version="1">MPSQSVTTTLTRTITVAGGIFAPGHLGELTQYLPFELIDDVLTRTRTVQRRTRLLPSRVGVYFVLALAVFPTLGYERVWDKLIAGLGSLLPRRPSEKGLRDLRRRLGAAPLRALFEVVAGPLAQPATPGVCYRHWRTVAFDGCGSLQAPDQDRIRMRLGKFTRYRGGTEGYPHLRVVTLCETGTRGLLGAVFGSIKRSETDYAATLVPLLNDTMLLLADRNFGGDDILTRVAASGAQLVVRLSSRRRPAVWATLPDGSVLTRINGYRFRIVDIQITATCADGSRTGDRYRIITTLLNHRTDPAIQIARLYHERWEIESAFFALRHTMFRGRVLRSTDPVGLEQEMWAALTIYQTLRRAMCDAVETAPGTDPDRASFTVAMTAAINQIVTATNITSNDSPENAIARAVLEKLLPARRPRISARKVKCPMSRYGTALTGNRPTKSQAVIRLELCALTDPQQTEAAEHPASTADPGHRQQVLQLLRTDPDRDWTPSEITQELKHVRYRSLCSQIGRWTDQGFLDRIGRGRYRLNRQWLAPEPPQPDGDSTTDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVP0</accession>
    <name>A0A231GVP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpB</name>
        <name evidence="5" type="ORF">B7C42_07255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40697">
        <property type="protein sequence ID" value="OXR40697"/>
        <property type="gene ID" value="B7C42_07255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="29602" checksum="E825B5780CCF80B3" modified="2017-10-25" version="1">MMSHGEQPDDRVEAEARGTAGTPEQARAEAAVAPADDAESGTVAENADVVPDERAPAAGNDADDEEAVRPLDDQELRSALEAMLLVVDAPAPVELLAAAVDDAPGRVERVLREMSAEWTARGSGIDLRYVGDGWRLYTRTEYAPYVERMLLDGARSKLTRAALETLAVIAYRQPVTRARVSAVRGVNVDGVIRTLVARGLIAEAGADVDTNGTLYVTTELFLERIGLASLAELPSLAPLLPGVDLIDEINESLETDPRYTRLKKPAESDIDLGTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVS8</accession>
    <name>A0A231GVS8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylase_S domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234857">
        <property type="entry name" value="S.Nce30759ORF7162P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40737">
        <property type="protein sequence ID" value="OXR40737"/>
        <property type="gene ID" value="B7C42_07161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="61"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="45605" checksum="E15E602979C9E4A1" modified="2017-10-25" version="1">MTGVQNKPLWSVASETRRQVEPSLLGESVVHYSIPSVDAYGIGQVECTVDIHSAKLLLRGGEVLISKLNPRKSRVVIVRRDDLPVVSSTEFIGLQAGPHLEDRFLAYFLQSEAVRQNLDARVQSVTRSHQRVAPEDVLHLHIDLPGLGEQRRIADFLDAETSRIDRLVALQSAVASKLRDREVVQRDAAIDRLIESEGVAPLRRFVWSVDQGSSPQCDSTPAAEGEWGVLKVSCLRPGIFNPGENKRLPDDVEPNRRSEVRAGDLLITRANTPQLVGSTAVVDSVRSRLLLPDKIFRVRLTARMSPQYVAEVAAGTRVRALCAASSNGASQSMANIRFEEVKAWPIPVVDLQEQERFVREMSRGRELLSSLHDAVDRQLRLLNERRQALITAAITGQFDVTTASGRNLTQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVT1</accession>
    <name>A0A231GVT1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40714">
        <property type="protein sequence ID" value="OXR40714"/>
        <property type="gene ID" value="B7C42_07138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="117" mass="12937" checksum="A7BAC58B85EDB4D6" modified="2017-10-25" version="1">MPSVLVLPPPIPQPDTRIPDDPTHDLGRPPKPKDLTMRHIMHNERELSERDGHERRDHQRPPRVADQNERHPAGHERNTDEAEPDDVVAGTAVHQARVGDTTQQSGVIAVGSGAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVY3</accession>
    <name>A0A231GVY3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40783">
        <property type="protein sequence ID" value="OXR40783"/>
        <property type="gene ID" value="B7C42_07207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="34441" checksum="BEA773A428B28405" modified="2017-10-25" version="1">MTTGRDRLRELLDSVLDENNTTLNAMAQGAFVSPYHFSRQFSRGTGESPVAMRRRVLLERAAWQLSGGAAVTDVAFAAGYDSVEGFSRAYSRAYGHPPSVTPAAARTRWLPAVNGIHFHPPMSLWVEGEPKGRHDMDPTSLLLHHDVEDTRELLDMAKGLDEHRYRRQRSSAAVLAWDGPDASIATVLAHLVWTKQVWLAAIAGTDQPDRGSDDLRELTRRFEETVPRWLDTVRDIDRRGGWDDTLIDALCEPPESFVLGSVIAHVLTYSAYRRLLVRQWIDSEFPDRTTEHDNGDPIMWLRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVZ7</accession>
    <name>A0A231GVZ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780101.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40794">
        <property type="protein sequence ID" value="OXR40794"/>
        <property type="gene ID" value="B7C42_07078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="13903" checksum="FFC76370BDFE215C" modified="2017-10-25" version="1">MSTASDRVLDDPTDAQLHDLLAELDYREPQLVVERPGSPAAQHYLRVEMDRRIDPDDGRGYIVEYGGGGPGMQFRASVRDTARWGTPHSPAFELVAKTVQDWAFQRYGWHEAMMWERVGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW26</accession>
    <name>A0A231GW26_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane transport protein YdhP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ydhP_3</name>
        <name evidence="7" type="ORF">B7C42_07249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40691">
        <property type="protein sequence ID" value="OXR40691"/>
        <property type="gene ID" value="B7C42_07249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="387" mass="39052" checksum="C8B831CF0D4BB728" modified="2017-10-25" version="1">MLRLGILIFCVFSVTTGEFVVAGILPEVAADLGVTVGAAGLLVTAYAVGMIVGGPLLTAVTAGIDRKRLMVALLTVAVAGNAVSALAPDFRLLLAARLLTALVTSTFFAQAVVIAVRSAAPERAGTMVARLAFGMNLAMILGAPIGTRIGGQWGWRATFATIAVACLIGLVSIARAFTSAPAAERTSAVAELRVLRRGPVLVALAITAVGNVGALMVFSYLAPLLTNLGGHPAGRLPLLLLAYGVGATIGNLVGGTLYDRNPRFAQPALLGLLAVTFVAAWFVATVTAFTVVAVVAIGLLGFAVIPGMQARVLRTAAAAPTLAMAVNASGYQLAAAAAGLVGGLIADSPAGPRPLYLVAAGLTACGLLMTVAATRMSRPEEADAMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW38</accession>
    <name>A0A231GW38_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase PknG</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pknG_2</name>
        <name evidence="7" type="ORF">B7C42_07123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40839">
        <property type="protein sequence ID" value="OXR40839"/>
        <property type="gene ID" value="B7C42_07123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031634">
        <property type="entry name" value="PknG_rubred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031636">
        <property type="entry name" value="PknG_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16919">
        <property type="entry name" value="PknG_rubred"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16918">
        <property type="entry name" value="PknG_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="188"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="809" mass="88109" checksum="0B6D921E99F078C6" modified="2017-10-25" version="1">MPERPDTPLPHPWANRRIRRSEVRGPDAHPWATRRNGGGEPSQRVRVAVESPGEPSVRHLVGDAVGNGGVATSFVPEPPSGPVTADVEADPLGSEAGSGRSARSRPSPRRLGAGLVEMPRVVSVDPRAAVLDDPEVPEEKRFCWKCNSPVGRSGDGGSGQVAGDCGKCGSPYSFRPILQPGEVVAGQYEVQGCLAHGGLGWIYLAVDRNVSDRWVVLKGLQNPQDFEAHVVALAERQFLSEVAYPGIVKIYNFVKHRGPGRDVADGYIVMEYVGGQSLKRVLDQRAPQRIPVAEAIAYVMEVLPALDYLHSFGLSYNDLKPDNIMVSEDEVKLIDLGAVAAMESFGSIYGTPGFQAPEITETGPTVASDIYTVGRTLAALVMQLPRDERGHQLPEMPGPQANPLLVRYPSLYRLLCRATDPDPARRFPSTYSMYCQLTGVLRMVLATDTDREHPQASVEFGSMRGDFGIETLIGQTDGIVDGRHRMPTLDARAVVAALPVPLMDSTDPSAELMSTLLHGDPRHALDTLRRIRDRIASGVLADTGSFELEGALTAVRAHLDLGEVEPARALLRELMIDYDTDWRLTWYRGIADLLDGAFEHAYTQFDTVHAMLPGEIAPALALAATAELVLQHLELPADPDRWHRAAVDFYRTVWRTNHGVVSAAFGLARRLAADGELLDAVAVLDRVPVTSRHYALAHMTGGLLLVSRPVAEVTEEDLTAAALRLEALPEEPRALQLQVVVVGAALEWLRAGGQPRRPEATLLGFALTESGLQLGLETSLRALARTAPGRLHRYRLVDLANQVRPRTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWJ8</accession>
    <name>A0A231GWJ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative enoyl-CoA hydratase echA12</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40952">
        <property type="protein sequence ID" value="OXR40952"/>
        <property type="gene ID" value="B7C42_06918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="29118" checksum="5346EA291F82B43E" modified="2017-10-25" version="1">MSFVLVEKPRPQIALVTLNRPERMNAMAFDVMIPLRETLESVAADNDVRVVVLTGAGHGFCSGADLQGAGRVPNVEGLTRTTVARRSMDLLDNVMTTLRRMHQPVIAAINGAAIGGGFCLSMATDIRIASEQAYFRAAGINNGLTSAELGISYLLPRAIGASRAFEIMLSGRDIDAAEAERIGLVSRTVAAGKLLDTCYELAERIIGYSRVGTELTKRMLWSGMEAGSLESHMQHEGTAQLYVRLTTENFDEAIRARRDRRTPVYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWT2</accession>
    <name>A0A231GWT2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gabD2_8</name>
        <name evidence="9" type="ORF">B7C42_06826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780301.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41056">
        <property type="protein sequence ID" value="OXR41056"/>
        <property type="gene ID" value="B7C42_06826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="511" mass="53223" checksum="FDDDC9F26F94BEF1" modified="2017-10-25" version="1">MSTTESTAGTASAQAAESARPTELSSLNPATGEVIATHPIADDDAVRAAVAKARAAAATWGGLSFADRKRALLRWSSRLVARADEFCDLIHAENGKPRDDAYLELMLALEHIAWAAKNAEKVLKPKKVSPGALMSNFAASIEQRPLGVVGVIGPWNYPVYTPNGSLAYALAAGNTVVFKPSEYSTAIGNFVGQAFVDANPDLPEGVFVTINGFGATGAALVRAGVDKIAFTGSTATGKKIMAAAAETLTPVLLECGGKDAVIVAADADIAAAADAVAYGATMNSGQTCAGVERVYVDKSIREPFLAEVKKILSNVHAGSDDKASYGPMTMPSQIDIVRRHIESALANGGTAVLGGPESVHAPYIEPVVLVDVDESSDAVSEETFGPTVTIRTVENIDEAVDLANNSKYGLGSAVYSRKHGLEIARRLRAGATSVNSVLGFAAIASLPFGGVGDSGIGRIHGAPGLLEFTSPHSIAVQRFTIPGMALLSYKRTDSTMKLLRKVVPLLHGRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWU9</accession>
    <name>A0A231GWU9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alcohol dehydrogenase D</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adhD_3</name>
        <name evidence="4" type="ORF">B7C42_06854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41084">
        <property type="protein sequence ID" value="OXR41084"/>
        <property type="gene ID" value="B7C42_06854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="12"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="368" mass="38467" checksum="6608FC50B1290568" modified="2017-10-25" version="1">MPTNITAAVLNTAPGTLELETLVLDDPGPDEVLLDVHYAGLCRSDLHEIEGVWPATCPTLLGHEASGVVRRVGDRVSTLRPGDHVVTCLSIYCGECKFCLSGRMTLCPRRGSLGSRSRPVLVNARGRSVHPTARLGAFAEAMVVHEHSAVRIPDTMPLATASVLGCAVVTGLSSVFRSARVEPGSTVAVLGCGGVGIAAIQGARLAGAREIIAVDAVAARLTDAVKFGATATVQAGQVDTVAAVRELTEGGVDYSFEAVGFAATVEQAFAMLGPGGTATVVGLVPDNQPVSIRASELFMLEKRLQGALMGSNQFPADIPGYVRYYEQGRLNLDDMISAVVSLEQINEGFELMKNAGGTRVVVRIGDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX40</accession>
    <name>A0A231GX40_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41177">
        <property type="protein sequence ID" value="OXR41177"/>
        <property type="gene ID" value="B7C42_06773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="850" mass="90866" checksum="3C6BA6AA58060B18" modified="2017-10-25" version="1">MSTSSTALDRPRGPRLFDASRQLEFWDAEQWQPRVVARRCWRRLTSTRRRRWITWSAIVVVVFLVVPMVVGAVATAAVETETEGPGGNSALGWTKVRDSYGVSLADYVYATNHGGILHPGNTGLAIVLGLLFAFFMVLVTLPTWMVGWVLDFGWMNVFSAPLNGVAHALSGQLATPIMLATFASFGAFFAAYFFQRGFHAKAVVQVLTMLVVAVIGPVYLSDPLGEVLSSHGLLAEGRNVGLSVSAGLNGNSNPDPSTMVPTLQEDMADNFARRPLQVWNFGHVVDDRPGCAAAWSAGVRSGSEGKIKDGMKSCGDQAAARAADNPSFGQIGAGLLLLITATILLIFAAYLSLKIIWSALDSVYWGIMTIFGFAGGGLVYGPTQTFTVRAVVHGMMSAVRMCVQIIALGVYLLFFGELFRQAKGQEMSVFVIGALVMIVGFLQFKRLTASLDSGNEWVANRFALAIQNPGRGGGGGGGGGGHALGMGEMGAHHKLGSGTMMAVMAGASTISNSPLTEWMLGALPGGFHPQSKLKKLMTEAQAGVWVDENRLGGKRGWYVQSMAKWEALSQEARKGARAYGGSRGIESIRGMAGAIQGVLDADGGIADSHGAMLGAGLKNDRLGHIVGRSRKIIAENASSESVADKDLSLLVAALRRTQNSARLLVNGKGDAVETAADFANLEQASRTFRRIKRGGVALDGGAASGVERDFVDDYMLNPTKEKMVALQAVIDGDDLNAGALATNRAAQHLQSVGIDGTTRLSRERAARMSQWIGNEHAKLIQKSTEHLMEDVTDANRIRDLRTLVFDAVNTDHWASGAQGTPWNSVAPRGQNNANPNWQSRMAEVARYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXF1</accession>
    <name>A0A231GXF1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41279">
        <property type="protein sequence ID" value="OXR41279"/>
        <property type="gene ID" value="B7C42_06677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021362">
        <property type="entry name" value="DUF2834"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11196">
        <property type="entry name" value="DEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="14967" checksum="0AFCF699EBDDA949" modified="2017-10-25" version="1">MAAHSSSNNRSTDIRHALYIIAGIAALLLTWPHAFDWMRDGGNILNPIAFFGDAIDAGGTAAFLSIDMLIAWAVFMVWVVTDTARIGMGRKWGVFFIVLSYIGVSMAFPVYLVARERFLARRGGAGSEDVARVAVGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXP0</accession>
    <name>A0A231GXP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_06509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41366">
        <property type="protein sequence ID" value="OXR41366"/>
        <property type="gene ID" value="B7C42_06509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045017">
        <property type="term" value="P:glycerolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="8">
        <location>
            <begin position="37"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="WES_acyltransf" evidence="6">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="WES_acyltransf" evidence="6">
        <location>
            <begin position="382"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="7">
        <location>
            <begin position="550"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="704" mass="75714" checksum="CD1939C18C30EFD2" modified="2017-10-25" version="1">MLWRDCVAGLAVFGLYLAVDALHTPARRELADRNAHRIFDLEQWLAIDVERPLNRWLESQALLATLANYEYAFTYIVSAFALLFWLYFRRRAEYARARDSFLLLNILAIACFALFPVTPPRLLPELGFTDTVVAGHTWGSWGSSLVSGANQLAAVPSLHVGWALWVSVVLARVSGGWIVQVLSALHVGLTTYVIVATANHFVLDAVIAVAFVAVSIQLVDRWYARPPVVPPADAFFLHIEKTGIPQQVGGMVVFRPRADGGPDLAAVRELVQGELAHLPRFRQRLDQPGRWRRARWVDSPVDWDWHVTERTIPGIDPDALGEPDGREAGAGATFSAVLTTGVAVGPAAGNGESAAVDSCGAATAEAAVTPGAVARRVDGISRVVTDLAAEVLPKDRPLWRLVLVRDPQAGAVGVVLLLHHVVADGIGTVVQALRLLRPTIDLPVAERKPPSWGTTVAGTAAGLAQLAADAQPTGTLPDDCVRRVFTVCSLDLETVRAVARSHRARVTDVLLSVTVTALQRLRPDLRERLRGQIRVAVPLMVRDPTSGAEGNSTAAVMIDIPLTAATPAQRLSEIRTRSDRLHSGTRALASHFVMDRVLRLCPEPAVGAFARSVYGGRYFHAIVSNMAGPELAMTFANMPITQVFPILPSAPGVPLVAGVLSWNGALGIGLSVDPALLDARAVAAELPDVLAELAETTFVSDKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXT2</accession>
    <name>A0A231GXT2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication and repair protein RecF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">recF_2</name>
        <name evidence="2" type="ORF">B7C42_06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41427">
        <property type="protein sequence ID" value="OXR41427"/>
        <property type="gene ID" value="B7C42_06570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="1">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="801" mass="86988" checksum="6B7F6C7A8AA56BF2" modified="2017-10-25" version="1">MGQEQGEAAPRLRELVSARLQADPAVSPEVAQTVLAALGESAEQSDAGPRSGVFLSAIRVRGFRGIGGEAVLRIAPGPGLTLVVGRNGSGKSSFAEAAELALTGVNRRWEGRSAVWRDGWRNMHCDKPPRIAVDLVAQERGPFTITRTWAEGDELSAGSWTERENDSDSADFRPEDWARALELYRPFLSYSELGAVVDGRPSDLFDALHRLLGLDDVSAALDRTRTRRIELERAAKQSRDGRQALLDELLTVADERAERVADMLRAPAPDLSAVAHELAGARHDPGGVAALQAVARLRIPASAQVESAAEAVERGTADLLELATGDLDAELRVVDLLRGARAHAEDGECLCPVCGHGRLDAQWQREATARIEAVERRAAVLTTARAALGEAIAAARALIEPVPPELESTIAAPNIDPADARRAWTTWSALLEVDAGATLAARMRGAHAELAVRLEVLQRAVHKELDRIDAVWTPLVPRIATWLHEARLVAAADAELRTVRRAEDWLKSAAAGLRDERLAPLAEHARRIWGGLRQRSNVDLGAIRLQGNAGASRKVLLDVTVDDSGAAALGVMSQGELHALGLALFLPRATVAESPFGFVMIDDPVQAMDPAKVDGLARVLAAVARSGRQVIVFTHDERLAEAVRRLRLDATVLDVQRREHSRVEVRAVEDPVQRYLGDARALLRTRQLPEAIATELVITCCRSAIEAAALARARRDLLAAGVDHREVQRRVDRARTTWETVALAVFGVPDRVDELNDYLDREAPWARAVVRDATAGAHIRIQRRSGDLISGTKRFVTWLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXU9</accession>
    <name>A0A231GXU9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41408">
        <property type="protein sequence ID" value="OXR41408"/>
        <property type="gene ID" value="B7C42_06551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="18333" checksum="FBCC696FD7170843" modified="2017-10-25" version="1">MDDRASTGDRVDEETPGRLNMKVAGPAMAAGAVSLGLVLIGACGIGHKDVYVAPPPLAADLQVATTPITRSGTTTAPAVIIPPSPTWRVAVNTPARRTTSATSTSTTTEADPSYTAFAPPAPTTTTQTPAPTTEPSAGEPSADSESPTTTRPHHTPRTVEESEPTTDSYRAPTIDDAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXZ1</accession>
    <name>A0A231GXZ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiseptic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">qacA_11</name>
        <name evidence="7" type="ORF">B7C42_06395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41503">
        <property type="protein sequence ID" value="OXR41503"/>
        <property type="gene ID" value="B7C42_06395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="35"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="898" mass="94323" checksum="817350997B05B21C" modified="2017-10-25" version="1">MASAQPAEDLDASDIQTIGRRLRVDHDHPHYKWVALSNTTLGMLMVTINSSIVIISLPAIFRGIHLNPLEPANVSYLLWMLMGFMLTSAVLVVMFGRLGDMFGRVRIYNLGFVIFSICAIALSFDPFDLGGGAIWLIAWRVAQGIGGAMLMANSTAILTDAFPARQRGMALGINQVAAVAGSFLGLLIGGLLAEWDWKAIFWVSVPFGILGTIWSYKSLHDNGARQPGSLDLPGTVTFALGLTALLAGITYGIQPYGDSKTGWGNPWVLTGVIGGIVLLALFCVIEAKSKQPMFHLSLFRNRTFALGSFASLMASISRGGLQFMLIIWLQGIWLPLHGFDFESTPLWAGIYMLPLTIGFLVSGPLSGYLSDRFGGRLFATGGLLLAAITFVLLIVIPVNFNYWLFALIILLNGLGMGIFTSPNTAEVMSAVPASQRGVASGMRATLMNGGMALSIGIFFSLMIVGLSGTLPGAMNSGLKDQGVPADVAGQIADMPPVGSLFATFLGYNPFKELLGPSGTLDKPGVHSEVLTGQEFFPHLISDPFHSGLVVVFLAAAVMMLLGSIASWFARGDYVEHEARELAEAAGAGLVTDADAEAETGRPATNGHPVPAGRHALAATAVMPAEAPPARSERSISGHVLRTDGHPLAGVALTLIDQQGHQVSRATGDPRGGYVIDPPAPGSYVLIVSARGQQPTAVTVAVDGRPQRLDVTLHGSGELSGFVRAAGRAVPDATVTLTDLRGQVVGAAVTDADGGYLCSGVVGGTYTLVAVAAHLRPAAMTLTVPDSGVLHHDVELLPLAVLTGSVRAGDRAVPDALVTVLDETGAVLGTARTDGEGRYSVTDLTEGTHTVVVRGYPPREARVEVAGGAVEHDVRLGYDLSAGSEAAEPDPSEPAFDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY22</accession>
    <name>A0A231GY22_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha,alpha-trehalose phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">treP</name>
        <name evidence="4" type="ORF">B7C42_06392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.64" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41500">
        <property type="protein sequence ID" value="OXR41500"/>
        <property type="gene ID" value="B7C42_06392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047656">
        <property type="term" value="F:alpha,alpha-trehalose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012827748" evidence="1">
        <location>
            <begin position="21"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65N" evidence="3">
        <location>
            <begin position="40"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="2">
        <location>
            <begin position="325"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="742" mass="78865" checksum="5250417C2C53E0D7" modified="2017-10-25" version="1">MIVVLGVVAAPPPVATATPADELWSATSESFAPGDFHAAPYLGNGRIGTVLPPSGGGYHDYGDAVRTSFPLQQSRYTGTYLAGFYAQAEPSPQYTQVIAALPAWSGLTVEIGGHRYDADVDPATVHEYRQTLDYRTATVTTRADWTPEPRYRLRLRYDTFVSRDRPDLAVQKLTVTPDNPGEVAVVDRIDGAAARRVVPVTATADPSTGRTVAGVRAHGTVDTAFVVSSVDSPPQAVGTALPGADGIRYVLPATGNDSYTFTAYTGISSTDYGPDPLAAATAAAESGRAQGFEAAHSAHAAQWDRLWEPTLEIPGRTDYTRWIRAALYSVLAGVRAGERWSVQPAGLSSDDYGGMTFWDAETWIFPTLLALYPDLARTVVDFRAAALPAARANARGYGLPGALYPWNDGPAQRCASPIGCGLTEEHLHNEIALAQWQYYLATGDRDWLRTRGTPVITAIADYLTARIGPKLPDGAYHFAPAAGSDEYVAFSIDNALTNGGVRNTMDIAARAAGLSGLPVDPRWADIGAHMAMPPDIAPGVPAEYLGYTGAPIKQADTVLLSYPFTYAAPGYSPAATMRYYFDRTDPDGPNMSNSVGAILSARYDPCRTQYYLDRSVQPYAREPYEFQAEARGDRSGANAQGQSAWIFVTGAAGFLQGLLYGPLGLRWTDSGAAVDPMLPGGFPDGLTIRELAIGATRMTVHIGPATTTLTLTSGGPITLQTPGGPAELVAGQPLSVPTRAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY54</accession>
    <name>A0A231GY54_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein LprE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lprE</name>
        <name evidence="1" type="ORF">B7C42_06410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41518">
        <property type="protein sequence ID" value="OXR41518"/>
        <property type="gene ID" value="B7C42_06410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025971">
        <property type="entry name" value="LppP/LprE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14041">
        <property type="entry name" value="Lipoprotein_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="9180" checksum="B7ED5E9F3D447616" modified="2017-10-25" version="1">MVVTVQGATASSPEHTLLFHRGDYVGTATPKAQAFTTIDTRAGTDDTVVLTYKTPGSCNACPDGTYTTVSFRWNGSGVDTQGRPPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ5</accession>
    <name>A0A231GYJ5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783111.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41676">
        <property type="protein sequence ID" value="OXR41676"/>
        <property type="gene ID" value="B7C42_06317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="128" mass="14642" checksum="B039AD5C8B0137D2" modified="2017-10-25" version="1">MELRRIHHAAIIASDYQRSKTFYTEVLGLRVVAEHYRAERRSWKLDLALPDGAELELFSFPDPPPRPSRPEACGLRHLAFAVEDVAAGLAELRGRGVVVEEVRIDEFTGRRFGFFFDPDDLPLELYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ75</accession>
    <name>A0A231GZ75_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41913">
        <property type="protein sequence ID" value="OXR41913"/>
        <property type="gene ID" value="B7C42_05897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="119" mass="13227" checksum="7D8E11AB4A96E8D5" modified="2017-10-25" version="1">MQACREAMKDLVVTGQPNPHAVLFPARNGSLRNPKNFGRAWRAARCENYAWVTPHTFRRVVATVVDNANGDPERAARQLGNTEAVAKAHYVDIPATAPDNREVFERWARGDVSKTVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZI5</accession>
    <name>A0A231GZI5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_05992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42008">
        <property type="protein sequence ID" value="OXR42008"/>
        <property type="gene ID" value="B7C42_05992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="22069" checksum="7AEA8E86188CBE31" modified="2017-10-25" version="1">MTSSAAIESEDDPRKARSRRRLLGAAAELLRDGGLDAVTIDAVTRRSGVARTTLYRHFDTVARLRAATLEELMPPVVEIPDAGPLRERLIELLTRQAAAINDVPLHLTTLAWLATGDAQAHGDGARAGTLRAHLIDTYRRPFDELFDDPRARALLGDRDLTAVLAQLVGPIVFVRLTGIGRAGRADCTRIVDDFLAACERDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZJ4</accession>
    <name>A0A231GZJ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scyllo-inositol 2-dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.371</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iolW</name>
        <name evidence="3" type="ORF">B7C42_05994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.371" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42010">
        <property type="protein sequence ID" value="OXR42010"/>
        <property type="gene ID" value="B7C42_05994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102497">
        <property type="term" value="F:scyllo-inositol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="36650" checksum="747A9A63DE4E0E85" modified="2017-10-25" version="1">MAQANVAVIGYGLSGAVFHAPLIAADPRLRVAAVVTSSPERAGQAREEHPGVRVFATADELFGAATDIDLVVIASPNRTHSSLTLRAVAAGLPVVVDKPFALTAAEGEAMIEAARRAGTMLTVFQNRRWDSDFRTVRRLMADGALGEVRRFESRFERWRPEIKGGWREVGGADEGAGILYDLGSHLIDQALVLFGPVDDVYSELDARRPGVRADDDVFVALTHASGVRSHLWMSAVAPQLGPRFRVLGSEAGYVCYGLDPQEAALRAGRRPGDGQPWGSVDPVDWGQLGAEGDLRLTPSEPGAYPDFYAGVAAALLDGAEPPVDPADAVAALRIIERARAVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H094</accession>
    <name>A0A231H094_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780551.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42266">
        <property type="protein sequence ID" value="OXR42266"/>
        <property type="gene ID" value="B7C42_05465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="20721" checksum="33386DEF4E58F784" modified="2017-10-25" version="1">MNATSVAPAAALAPVWRDVVADSYRALADAVAGIGAAQWDLPTPCSQWTVTQVVQHAAGDQLAFAAALGVGAGPAYDPFAPSGSLDGTGVELISAALDQTATAWATVTDAAETVPTPLPHGALPTPVAAVMAALDAAVHAWDIAIATGRPSPLTDTLATHLLTAATDLIEPLRQWGAYAAVLDAEPGDTPTDTLLRYLGRNPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0J3</accession>
    <name>A0A231H0J3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">icaR_3</name>
        <name evidence="5" type="ORF">B7C42_05595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42395">
        <property type="protein sequence ID" value="OXR42395"/>
        <property type="gene ID" value="B7C42_05595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="217" mass="23878" checksum="5801F7C19B58EF75" modified="2017-10-25" version="1">MTSGDAARAPRPRMTGTQRRQQLIEIGRALFAERGYDATSIEEIAQRAQVSKPVVYEHFGGKEGLYAVVVDREMSTLLDMITSSLTQNRSRVRLEQVALALLTYIEERTDGFRILMRDQPASAAAGTYSSLLNEAVNQVAHILAGDFERRGFDTSLATLYAQALVGMVATAATWWLDERQPSKEVVAAHLVNLCWNGLTHLEADPQLGSEWPSGTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0K0</accession>
    <name>A0A231H0K0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ligase</fullName>
            <ecNumber evidence="4">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42405">
        <property type="protein sequence ID" value="OXR42405"/>
        <property type="gene ID" value="B7C42_05606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="448"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="548" mass="59063" checksum="B115BFF6DE4B5844" modified="2017-10-25" version="1">MSRFTEEMFATAQRSRRGLITGEPETPLRRGWDEIHRLARRMAGGLAAAGIAHGDAVGVLAGMPADIAPACQAIWMRGASITMLHQPTPRTDLQLWARDTETVLRMIEARAVVLGAPFEVAAPLLAERGITVVLTDELATGPDTDPLPTEESDIALQQLTSGSTGSPKAVRITHENFYVNAYAMFDRVKFQLDQDVMVSWLPLFHDMGMVGFLSVPMQLGAEVVCVTPMDFLKRPILWAELISKYRGTVTAAPNFAYSLLTRRLARAEDGAVDLSSVRYMWNGAEPVDPDTMDALAAAGKRFGLSASALTPVYGMAETTLAVSIPDPGVGQVVDIVDADLLEALGKAVPATDPTAHHGNLRRLPLLGRPVDNLEIRVVDDEHRPLPTRTVGVLEVRGPAVTAGYVTVEGFRPARDAEGWLDTGDIGYVTEDGSVVVCGRIKDVIIMGGRNIFPTDIERAALRVAGVRPGNAVAVRLDAGQKRESFAVVVESNDFQDPETVRRIEHEVVHEVFTAVGARPRSVTVLGPGALPKTSSGKLRRSATAAHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0X1</accession>
    <name>A0A231H0X1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778135.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42520">
        <property type="protein sequence ID" value="OXR42520"/>
        <property type="gene ID" value="B7C42_05296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="33590" checksum="21E276E1C6503335" modified="2017-10-25" version="1">MPDSTRPTSPVELIGQRFRGGGSAGEHADGFRLALVVEGGSARGVYSHGMVTGLEELGVLRCFDAVYGASAGALNGAWLLCGRAARARRAWHSDVVRRVISPARALRGGLVVDTRYLVHTVYERIVPMDFAAILGNAVTFHPIGTDIADGSAVDLRPHISDIPSLQRALRASTCMPVLAGRPVAVGGGRYVDAGLSESVPVTTARAQGATHIVVLRTRRVDEKPSIPSDFERRVVARVLGASGPTVAESWFTRAAQFAADEHRMASDPSILQIRPPLGAPTIGRVARDSTVLLRALDLGRAAAVAALGEAVRSAEDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H193</accession>
    <name>A0A231H193_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42624">
        <property type="protein sequence ID" value="OXR42624"/>
        <property type="gene ID" value="B7C42_05402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19593" checksum="AA6BFF9C84494367" modified="2017-10-25" version="1">MPHRDEHLLDGEIGPQIPPRRVVGEFGAQQRDDALTGGVEASIGAVGRIEDGDERHRIDQLRHNRRHDGFRGDIRAGGELLQIRHIVLEDRDDDRFAVREMPVQAALAHSRTRGDQPQRGVGAVFGEHLTCRGQQRRPVLGGRGPTAVDTHRHTSFSTAGVSSMRITVASRISAAIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1K3</accession>
    <name>A0A231H1K3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaD_2</name>
        <name evidence="11" type="ORF">B7C42_05072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42735">
        <property type="protein sequence ID" value="OXR42735"/>
        <property type="gene ID" value="B7C42_05072"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="24"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR42735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="581" mass="64725" checksum="8026150479F50449" modified="2017-10-25" version="1">MTTAPSRGAAEIEAVRPYPRRIAPKGSQIWTIVTTTDPKLLGVMYIVSSMAFFLIGGLMALLMRAELARPGLQFLSPEQFNQLFTMHGTIMLLFYATPIVFGFANCILPLQIGAPDVAFPRLNALSYWLYLLGASMATAGFVTPGGAADFGWTAYTPLSDIVHSPGVGCDMWIMGLAVSGLGTILGGVNMLTTVVVLRAPGMTLFRMPMFTWNIVVTSVLVLLAFPILTAALMALMVDRHLGGHIYDPATGGNLLYQHLFWYFGHPEVYIIALPFFGIVTEIFPVFSRKPVFGYTALVYATMSIGALSVAVWAHHMFATGAVLLPYFSFMTFMIAVPTGVKFFNWIGTMWKGQLTFETPMLWALGFLVTFLFGGLSGVILASPPLDFHVTDTYFVVAHFHYVLFGTIVFATFGGIYFWFPKMTGRLLDERLGKIHFWTTFLGFHTTFLVQHWLGNEGMPRRYADYLPSDGFTALNTVSTIGSFILGFSMITFVWNVFRSYRYGEVVTVDDPWGYGNSLEWATTCPPPRHNFYELPRIRSERPAFELHYPHMIDRLRAESHIGWGAPHAEVHETAPAAPERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H278</accession>
    <name>A0A231H278_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42951">
        <property type="protein sequence ID" value="OXR42951"/>
        <property type="gene ID" value="B7C42_04837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="748"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="805"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="853" mass="92494" checksum="834DC317BFC41937" modified="2017-10-25" version="1">MAPLRVGTVPTTSDEFIGREPELGRLATLLSGPARLVTVIGAGGLGKTRLVTEAVHRLPRTGERRVHWVRLARLAAGTDAAGVAEDVVRAVVDHDFSGRDPWPALRDTLTAAAAPPVLVMDNCEHVTDGAGQVIAELIETVPGLTVLATSRRPLGWVDEQLLPLPPLTQRQAVELFHQRAALTGTVLSPDSAGTVASICRHLHHYPLHIRLAAARLRRRPPAVILRDLDGRAGDTRLHWPPATLVGADTRHRGITDVIAWSFELCDERERLLFERMSVFAPGYDVNPADADADSGLEVGADLDAIVAVCSGLDTADGSGAEPAAAEVEELLERLADQSLVTVHLSARAVRYSLLESLRLFARERLAERDPREPRRLADRHRRYYRDRITSSDDGDGRLPQWARASWDNLLLAIDRSLDSPDDAVAGLEIALGMIALHVPFFRGSLRESRRRAEKTLAVAESAPEPLRIRAMATIAWICLCQGLPGEAEELLDRCVAAAVPEPAARERLAADPTAEVPLPAPVVFTLGCRLMLVEQDVRSLVLLSRAHDMFTTAADYGHSAICALFEALAAAFLGTPEQALAVTARHLEAADSGADWAKSWAEIARIIAQTLHGDARWAAAAAPATLARQVATRDTWGVVWSVHARAWALARLTFDTPHPAVPRATAVEIARLLGAAAALRRRLGVEIAQLRPFVAETDRAADGIRRLLGPRAFDAAYREGTEVRPTLTEISQLACDIAVPDERPARPHAPEWDLLTRAEQEVAALAAAGWTNGEIAARRGSSARTVDAQVAAVLRKLAVASRADIAPRVPPERRTRAAHTPRPRRYRTESAAPASSVTRVSERPREPGPARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2B9</accession>
    <name>A0A231H2B9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42988">
        <property type="protein sequence ID" value="OXR42988"/>
        <property type="gene ID" value="B7C42_04874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="9778" checksum="AD57944FEF3E4560" modified="2017-10-25" version="1">MGGNHCGMTENTAESTTKPAETATPEPDEQTRERAKKEAERLDEIYEPGARASVVVPGTDGMVAGTAFADAVDEQITENKPPDELRKDNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Q4</accession>
    <name>A0A231H2Q4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43131">
        <property type="protein sequence ID" value="OXR43131"/>
        <property type="gene ID" value="B7C42_04553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="127"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="379" mass="39474" checksum="A7FB0D1863294BE0" modified="2017-10-25" version="1">MRCEKRLAAVALIGGLTLAASGCQWEGPNSLPLPGTAGGGPGSYSVKIEMPNVMSIQRNSRVRVNDVTVGNVADVQLEGWHAVVTVTLDRDVHLPANATAKIGQTSLLGSLHLELASPLSEPPSGELKNGSVIPIEHAGTYPTTEQTLASLSTVLNGGGLARIQEISNQTNAALSGHEKEVRDLLSQTSTFSSDLNAQSDDIITAATGLDRLADTVGKQNDVLAGALDRIPPALSILAQQRQQLTDTVTALGGFADSADRVVTASSEDVQQNLRDLQPVMRELANAGPDLTGALGLLPTYPWPLANIPKFFRGDAGNLSGTVDLTLGRLGRGLLQGTPLEGVLENAETSLGRTVDRVPALSTKNPLTAGLDSVVVRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3A3</accession>
    <name>A0A231H3A3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Positive transcription regulator EvgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">evgA</name>
        <name evidence="3" type="ORF">B7C42_04698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064908351.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43276">
        <property type="protein sequence ID" value="OXR43276"/>
        <property type="gene ID" value="B7C42_04698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="13919" checksum="E8CE923BAE44CEB2" modified="2017-10-25" version="1">MIARADSLCCVIVDDSPFFLAAARNLLQQQGISIVGVAATVSEALRRVEELRPDLALVDIDLGGESGFELAERLAGTSVPVVLISTHAQQDFADLIAESPAVGFLAKSDLSSVAILALLDGRDGDRISAIRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Z1</accession>
    <name>A0A231H3Z1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779296.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43472">
        <property type="protein sequence ID" value="OXR43472"/>
        <property type="gene ID" value="B7C42_04339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="203" mass="22656" checksum="EFBF3E0B77CF552E" modified="2017-10-25" version="1">MPAYEPIAADGLVERVVAAALALPGPVVVAVDGADGAGPREPADRIVDRIRTSGRPAARVWLHDFVRPASLRLEFGRDEMTYRTAWFDYAALDREVLEAVRRRGRWLPALWDEAEDRSARARMQSAEPGLVLVVAGPMLLGRGLDFDVTVRLQMSEAALLRRTDPADRWTVPALLRHDREHADVPTFDVRWDHPDRPALRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H411</accession>
    <name>A0A231H411_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43663">
        <property type="protein sequence ID" value="OXR43663"/>
        <property type="gene ID" value="B7C42_04531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="7697" checksum="DA873BC73C51543B" modified="2017-10-25" version="1">MIAASPRRACLTLRGLRIERPQHRLIILAACVSHTVQWPIYRFWDFQHRRFRLRPCAERISATGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H468</accession>
    <name>A0A231H468_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycyl-glycine endopeptidase LytM</fullName>
            <ecNumber evidence="5">3.4.24.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lytM</name>
        <name evidence="5" type="ORF">B7C42_04373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.75" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43506">
        <property type="protein sequence ID" value="OXR43506"/>
        <property type="gene ID" value="B7C42_04373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="443"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="566" mass="57170" checksum="E79D7DD69BE97B91" modified="2017-10-25" version="1">MNAKTLTALVLGGVVSLITLVVVIVLPSSEDPCADQPTAPGSGLPDTSGAPWAARATESGSTTPTTTDPHGSTTATPGAADIPAAQANPSVTGAPSLAAGIAPIRRTWPLPGGSFTVSDTFGARGGTHLGVDLAAPDGTPEFAVADGVVVAAGPASGFGNWIVIDSVDVNGRPFSAVYGHEWASGVKVRVGQRVRAGQEIGAVGSAGESSGPHLHFEIVPGGRLTGGHQIDPLPWLDGALTPSGGGAFPYSVNPLCSRGFGSAGGALADGKVPPELEIWYRRAGSLCPEITASVLAAQGRQESGFQRGLTSPAGAEGLAQFLPTTARATDPDDGHPYLLDADGNGQASLWDDGDAIIAQGRYMCSIAHQVERWIGEGKVHGDVVPLSLAAYNAGEGAVLASGGMPNQVAAHFSETRPYVTNILAMEAQYRAPGSMGRFQPGHGSAGADILAAAQQWMGTPYVWGGGGPQGPTGGGLDGPGLTSAAVFAASSGAKTLPQTAEQQWEAGAEVPMRDAQPGDLVFSRFGVRGPAEVGIYAGNGRMIRAGDPSGVSEAPVPGDARLRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Z1</accession>
    <name>A0A231H4Z1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiseptic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">qacA_7</name>
        <name evidence="7" type="ORF">B7C42_04208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43969">
        <property type="protein sequence ID" value="OXR43969"/>
        <property type="gene ID" value="B7C42_04208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="565" mass="58172" checksum="D94362164BD00546" modified="2017-10-25" version="1">MADHVRTDAELGSPPTGARRWYALAVLALGLGMVTLDGTVVGVSLPAIIGDLGLDFTQAQWVFCVYSVVLAALLITVGRIGDRFGRRALFALGVLIFVGGSLLSASADSASPLIWGRLVQGIGGAAVVAGSLGSVAAMFHGRARVIAFTAWVVAPAAAAVVGAALGGWFVDSFTWPWIFLINVPIAVVVLIGTVLVPETRIGAAAIGPDVDGWLLSTAGFALVIFALIEGQRYGWLRPRREFTVFGVTWSTQSASSPIPFVLGVGVLLLVLFVFWERHRVKVEHAALVDFSQLRDPRHWGDGAALLIAAAQFGVLFVLPLYLVNCLGLSTLRTGSILVVLTGCALISAVLTAGPLRTVPPLWLIRIGLAIALLAMAVTALALTSTIPAWVPTVLLACYGVGLGLAAAPLTASMRTGAGAMASDPGSITAATARPAGAALGVAVLGSTLSIGLGHFLPDRLSYVPGLATRAAGAVGAATRDSAGGAIVGLRAQHAPAAVTDALANGFADATRVALLGVAVVLLLAFVVATRIPSDAEQIEAERIQAERIQGERIQGERIDGEPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H542</accession>
    <name>A0A231H542_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03619</name>
        <name evidence="1" type="ORF">B7C42_07976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000050">
        <property type="protein sequence ID" value="OXR39942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39942">
        <property type="protein sequence ID" value="OXR39942"/>
        <property type="gene ID" value="B7C42_07976"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44063">
        <property type="protein sequence ID" value="OXR44063"/>
        <property type="gene ID" value="B7C42_03619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="667" mass="73605" checksum="C8EE9A72E7EB5D12" modified="2017-10-25" version="1">MSPLGSDDDTLDRRLATLDEATRILGDTSDFGKQVKLSRVLGALRRVLLLPGGCAAVRARASRLEAAGLFLGTDWAHPEILIPALSVGSLRSANADTMVLETVSDLRLLAVAKGDYPHPSVSAEQALGHLSQVLAVNLSLLFTPPSEAEREQQGRMARVSRELLHHLVEEIGYEKVLEHLVDEIWRILRQRPIQVEQVKRMITQIAVARSNPDIDLGASGLGADRLISSLYGTTDACREDPGVEVYRTRLESMDDSALQYEATGFARSMHDTGLVSPYHAVLLRFLLTKGEYLLGEALGLSSTGRDSLLCYHELVRNLIEEAVHVETAQGIYGLALLLERGILYQPPVAPALWRQLALPVSPRSAERLHEVFGPVPDARARLLSGMLSILGLPLGVGQGDNPTCQSARALSMWAYNDPDYLLQTVAWAARDDEIVMHFEGQPISSLEAGAGVATTLPMDLDPVSLLVVPHLDRIYAEMGRRCVGREGDPHRWINPEFHGWWSGRGFRINVDVETGRLIDVDEFLRHFYASYHPFYNGNQPLIHPQPAGIAVTDSAARFVGWHAITVLRVSLDPQDTMRVYFYNPNNDSGQDWGDGVVVGTAGHGERFGEGSLPFEQFASRLYIFHFDPLERGEPAAVERTELDRVVGYIHRSWGADRLPEIVSDAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5W1</accession>
    <name>A0A231H5W1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44152">
        <property type="protein sequence ID" value="OXR44152"/>
        <property type="gene ID" value="B7C42_03711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="32513" checksum="085CBA23DA1D30AD" modified="2017-10-25" version="1">MPIPDGLDGMRVDAGLSRLLGLSRTAVAALAEDGSVQIDGTAAGKSDRLVAGAWLEVEFPEPKRELTVEVTPVEGMKILYADDDIVAVDKPVGVAAHTGVGWSGPTVVGGLAAMGYRISTSGAHERQGIVHRLDVGTSGVMVVAQSEHAYTVLKRAFKQRTVDKRYHALVQGHPDPSSGTIDAPIGRARGNDWKFAVTADGRPSVTHYDTVEAFQAASLLDIHLETGRTHQIRVHFSAIRHPCCGDLTYGADPRLADRLGLQRQWLHARSLGFAHPADGRWVEITSDYPDDLEHALDVLRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H698</accession>
    <name>A0A231H698_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_9</name>
        <name evidence="2" type="ORF">B7C42_03332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518640.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44543">
        <property type="protein sequence ID" value="OXR44543"/>
        <property type="gene ID" value="B7C42_03332"/>
    </dbReference>
    <dbReference type="GeneID" id="66718677"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="26479" checksum="C96B76482BEA217E" modified="2017-10-25" version="1">MNEVLAVPLRAVGGFFELVAAVARALIRPPFQRREFVDQSWFVARVSIIPTILVAIPFTVLVSFTLNILLREIGAADLSGAGAAFGTVTQVGPIVTVLIVAGAGATAICADLGARTIREEIDAMKVLGIDPIHRLVVPRVLASMFVAALLNGLVSTIGIAGGFLFSVLLQGVNPGAFVNGLTLLTHTPELVISEVKAALFGLIAGLMACYLGLNVKGGPKSVGDAVNQTVVFSFMALFVVNVVVTAVGIKFTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6A7</accession>
    <name>A0A231H6A7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-(S)-hydroxypropyl-CoM dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.269</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xecE_2</name>
        <name evidence="2" type="ORF">B7C42_03190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.269" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775688.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44401">
        <property type="protein sequence ID" value="OXR44401"/>
        <property type="gene ID" value="B7C42_03190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050575">
        <property type="term" value="F:2-(S)-hydroxypropyl-CoM dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="29502" checksum="B7844229DCBE44A6" modified="2017-10-25" version="1">MTDFGKINGKVVVITGGARGIGLATATRLQQLGAKIAIGDVDETAVKQSGTDHDFDHYGRVDVTDQQSFSSFLDEVERALGPVDVLINNAGIMPTGKVVDEPDALTRRIIDINVYGVILGSKLALARMLPRRSGHIINIASLAGETHIPGLATYNATKHAVLGFTDTLREEYRDTGVSFSSVLPTLTNTELGSGVSAPKLMRPAEPEEIAEAIAKLLVTPKSKVRVTKVAGAISQVVGLLPESVGDAIGRALGAQQTFLGDVDSAARKAYEERVRSGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6T2</accession>
    <name>A0A231H6T2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyl-CoA dehydrogenase fadE25</fullName>
            <ecNumber evidence="5">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44490">
        <property type="protein sequence ID" value="OXR44490"/>
        <property type="gene ID" value="B7C42_03279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="235"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="366" mass="38525" checksum="617776AEA5C33B30" modified="2017-10-25" version="1">MTDTAELQELAATVRAVLTRHGDRAALRQAIDSELGYDERLWHLLCEQVGVAALAIPEEYGGVGADLDTALVVLEELGRTLHNPPMLGSAVLGVQALLATGDADAAQRLLPGVAEGTRTLALCWADEKGWAAGTAGSASAARVPAGYAVRADGDTLTGTAHYVLDGANADTLLVVTADGLYEIDATAAGVTRTVVRTMDPTRRLSTVAFDGAAATRLGGDADAITARLRAVAWTALAAEQVGAADQCLDLTVEYSKSRVQFGRAIGSFQALKHRMADMYVLVESARSAAYAAIADLDRPVSAETTLDLESARIHCSHAFRSVVSETVQMHGGIAITWEHDAHLFFKRAHGDAELFGMPGRPLARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H774</accession>
    <name>A0A231H774_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44709">
        <property type="protein sequence ID" value="OXR44709"/>
        <property type="gene ID" value="B7C42_03503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="30725" checksum="146524807B8984B9" modified="2017-10-25" version="1">MLELDHFSHGWVTPVLAYLMSFIGSVLALRCATHARASRWPGGWLIAAAVSLGGAGIWVMHFTAMLGFSIHGANIRYDVPMTLLSAGIAIVVVWAGLSIVVRGHREAIALPLGGMITGFGVAAMHYLGMHAMHAGAHIEYSTGLVALSLLIAVVAATAALWFVLHVRGFSATVGAALIMGLAVCGMHYTGMAAMTAHRMDNMSEPAGGVDSVQLLTPLIMVVTLVTIMLVVLVGLAEVDGPSRRENPDTPGDLDLADSGRAWPRAYTEESPAPDQPAFGLQAISKRQSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7N4</accession>
    <name>A0A231H7N4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44891">
        <property type="protein sequence ID" value="OXR44891"/>
        <property type="gene ID" value="B7C42_02846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="31322" checksum="D54BBDC624C432F5" modified="2017-10-25" version="1">MTNDAHRRREQLREFLRSRRERLTPAEVGLAPSGRRRTPGLRREEVAQLAGVGVSWYTWLEQGRDITVSADVLDAVARALRLTEWEHAHLYVLAGMNPPRAVGNRDARVTEELRHLLTVWSPRPAVLRDRYWNILAVNDGARTAFGYDCADYNCLVSFFTNASYREMHLHWTAAAPAVVAAYRADAAQGEPEFDRVITELSTVSPEFAELWARHDVGAPTQTVHAVRHPDAGDLYFDTTTLIVADHPDLHLVLYNPRPGTETEQRLSLLTPERSAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7U9</accession>
    <name>A0A231H7U9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44827">
        <property type="protein sequence ID" value="OXR44827"/>
        <property type="gene ID" value="B7C42_02781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="16418" checksum="A7A40EDD896AF16E" modified="2017-10-25" version="1">MTDLDPARLASVISPLRRSLLSAARAAEHLPDIPDAQIEIVRALPPGTVSTSSELAERLGLSRPTVSNLLTAMEASGLVERRPRPGDRRHVEIATTARAHNLFARFDQASGALITAAAATLDPEDRAALATALPALERLREALQRLQTSEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H801</accession>
    <name>A0A231H801_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsfB_1</name>
        <name evidence="4" type="ORF">B7C42_02958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45001">
        <property type="protein sequence ID" value="OXR45001"/>
        <property type="gene ID" value="B7C42_02958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="12443" checksum="8D8D838FAB96D867" modified="2017-10-25" version="1">MSGERVSPLLRTEQRTEGSAVVVTVAGEVDMNSAPELQSALDRALQGEPTAVVLDMTEVGFLGSAGLSVLLATSQSTATGGLRVVASPAVRRPIEVTALDALLPLFPTVADALAAPEQTTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H807</accession>
    <name>A0A231H807_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trehalose monomycolate exporter MmpL3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mmpL3_3</name>
        <name evidence="8" type="ORF">B7C42_03031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45074">
        <property type="protein sequence ID" value="OXR45074"/>
        <property type="gene ID" value="B7C42_03031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="204"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="714" mass="74496" checksum="5B286AE59D021DC6" modified="2017-10-25" version="1">MTRWARLVGTRPTLVLLAAIGVAIVCGLFGADVQQRVSAAGFADPGSESALVERVVTAHLGRQNPDVIAIYTAADGQDLAALGPRVQQAVDHIDPALLAQPVQTYWNNVPPRQSLLRSADGRQGLAVVFAAGDDNQRIAAYHDIAAALTVPGVSVRFTGYSALADEIDRQSRHDLILAESVSLPITSVILVLVFGGVVAAGLPLLVGVLAVVGSLGAVGLIAHVTEVSVFAVNVASLLGLGLAIDYGLFVVTRFREELAAGAAVSEAVTRTLATVGRTVGFSALLLACAFAGTFVFPQAVLRSLGFGAIAAVLLAAGLSLTVLPAALALLGHRVGAWSWRRDAFDRGQRRAERWWGRVVDAVVRRPGLVAVTVGGLLLVLATPVLGVRLGDVDHTALPAGNAVRAGVDELATRFPEAGSGATVLLRGDGAPPDSRPTAAAIRALGAIPGVHDVQRLATVDDAVVLHAALNDPDRSPAATETITRIRELDLPDGVYIQVGGETAATVDSVAAITSRMPLMIAVMVLATLILLGAAFRSAVLPVKAVLLAFLSLAATFGILTWIFCRGHLADLLHVSVGPLSAGMMVLIIAVVFGLSTDYEVFLLSRMVEARHAGCDTVSAVRAGTVRTARVITAAATLLVFITGAFTLSPLTPMRFLGLGMILALIIDATLVRMLLVPALVRLMGPLNWWPMRPARDRYPEGNGPRARVRASSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H859</accession>
    <name>A0A231H859_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative siderophore-binding lipoprotein YfiY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfiY</name>
        <name evidence="3" type="ORF">B7C42_02996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45039">
        <property type="protein sequence ID" value="OXR45039"/>
        <property type="gene ID" value="B7C42_02996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257563" evidence="1">
        <location>
            <begin position="35"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="36877" checksum="BB112B12E7FB22CC" modified="2017-10-25" version="1">MPVSERVSTRKPKTRKRTSARRLALGGAAVGALAVLVTGCGTGGDDASSSIVRTTTNIAGASVVGIERDTTRACALPSAPDQASGTHTVAGTQVSADPKRIVVLDTAALDAVCAVGLWERVVGATTTAGPASQPNYLGTGVLKIPSVGTSGAVDTAKISTLQPDLILGAAGDGDLAALRGIAPTVLVDHRGWQDDFTAYAEALGRGSAGAKALADYRTDARETGASIAANLSQASVIRFSPKDIQAQGTDTFAGQVLADAGVQRPGAQRDGSFTVDSLATESDRNKIEGDIIYLMFDGPDGKSHGESVMKSDDWKKLGAIVDKRDFAVEDDLWHGSGLTAARAILDDLRKTLNGYVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8F6</accession>
    <name>A0A231H8F6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45118">
        <property type="protein sequence ID" value="OXR45118"/>
        <property type="gene ID" value="B7C42_03075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="117"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="35820" checksum="EAE464EB4B29694C" modified="2017-10-25" version="1">MKSTKALIGFGIFAVVAIALTSTIYGTLQRTVPGSTSRYSAVFSDVLGLRVGDDVRMAGVRVGRVDKIDFVGDYKAGVEFSIRSNQHLTTTTKAMVRYQNLIGQRYVALAPGKEAGAPLPAGGRIPLEHTEPSFDVSALLSGFEPLFSVLQPDQVNSLSETLIQALQGNQVSLSTLITQAAQLAGTFGRRDKILGDVVSNLSSVMSGLAHRSNELETLITQTRSLMDGLYAQGEALKSSVDQVATSTDSLVGLVAQVKPGIAAAQNKATTGVALLLLNGASLDRAAVQLPNVLNRVAQFSSYGAYGNAYFCGLDVSLWGVLLPPGLFSQIGGNAHSEVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8K3</accession>
    <name>A0A231H8K3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45175">
        <property type="protein sequence ID" value="OXR45175"/>
        <property type="gene ID" value="B7C42_03133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="32159" checksum="152C62E48DED97C1" modified="2017-10-25" version="1">MTNSEHINFRCRKVAGDRTPLEVVSSAFDRIAREPVAAGPPPPRGVAVRTWGDVGEQLRAPAMPVDAVWSWLIQRARLEWGQPGGRAGVACAGLAVPMLAGITGRFAAPGSVDRDDAEAEIIAGFLRQVREIDLEPPRLWSRLWSVTVHVGRSWARQQALAPQAIDLDLDTADGPPPITQTPHGHPELVLADAVAEGVITAEAAELIAATRWERRSMTSVAEQLRGSQSHWKVRKQRQRAETKLGSWLATRIESLDPAPDSTGHRAGSSAQVRSTGSGRGRTRTALQGGQQEVRRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8P4</accession>
    <name>A0A231H8P4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45190">
        <property type="protein sequence ID" value="OXR45190"/>
        <property type="gene ID" value="B7C42_02315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="191" mass="20789" checksum="65DD38BE108A19D2" modified="2017-10-25" version="1">MSEQTAPRRSNATRAAILEAARRHFAREGYAKATIRAIAADAGIDPSMVMRYYGNKDGLFDAALDVDLALPDLAAVAEDELGATVARRFLELWETPPGNELLLTLLRSSVSDETVAQRFQRVFAEQLMPMVTRVGDPADAPRRAGLVVTQILGLAVCRYVLRLPPVVALTAEEIVAEIGATVQRYLVSVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Q7</accession>
    <name>A0A231H8Q7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45182">
        <property type="protein sequence ID" value="OXR45182"/>
        <property type="gene ID" value="B7C42_03140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="284" mass="32125" checksum="3973238DAC759E39" modified="2017-10-25" version="1">MTDASRPRDTREDRYDWEKARGMITAFGQSKTLTQWSKDPRCVVSRESVRTRLALGWEPEDAITRAKHDKPALEFTHNGRTLSLRGWAEQTGIKYHTLYRRITKAHMPFADALALGPDGPQLRLPVTAFGETKPMYMWGVDARANCVTTTLRRRLLAGWEPEQAITSEPDNRNTLGTGAPVSAFGDRMGLEDWARRTHIPAPVLRQRMDNHDLTLEQTLRSFGWTPLPTHQDTTKADLLEVSADELRTGDTIAAVIADTHSNRPRFTVRRINLPTADRAADSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Q9</accession>
    <name>A0A231H8Q9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pntB</name>
        <name evidence="18" type="ORF">B7C42_02363</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776764.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45238">
        <property type="protein sequence ID" value="OXR45238"/>
        <property type="gene ID" value="B7C42_02363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="17">
        <location>
            <begin position="6"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXR45238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="470" mass="48304" checksum="8D7FC59476FA4736" modified="2017-10-25" version="1">MDNLVNILYIVAFSLFIYGLMGLTGPKTAVRGNWIAAVGMGIAVIATFISIRDTSNWIIIIAGLVVGVALGVPPARFTKMTAMPQLVAAFNGVGGGTVALIAWSEFLNSDGFSSLHEQPTVHIVIGSLFAAIIGSISFWGSLIAFGKLQEILPGRPIGLGKLQQPVNLLLALGAIASAVVIGIGATKDGAPWWWMVLLLVLAAVLGLMVVLPIGGADMPVVISLLNALTGLSAAAAGLALNNTAMIVAGMIVGASGTILTNLMAKAMNRSIPAIVAGGFGGGGGAAASGDGEQKQAKATSAADAAIQMAYANQVIVVPGYGMAVAQAQHAVKEMASLLEAKGVEVKYAIHPVAGRMPGHMNVLLAEAEVSYDALKEMDDINGEFSRTDVALVIGANDVTNPAAREDSSSPIYGMPVLNVDQAKSVIVLKRSMNSGFAGIDNPLFYADHTSMLFGDAKKSVGAVTEELKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9B3</accession>
    <name>A0A231H9B3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783987.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45613">
        <property type="protein sequence ID" value="OXR45613"/>
        <property type="gene ID" value="B7C42_01905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18048" checksum="C0E8D86CB7AB3B53" modified="2017-10-25" version="1">MNDSQPLSRVQRNTDALLIISVVAVWWALLGPVWTYVPATATTPATTLTFADLAAMNAANPSGLQVAFYQWVAWTFAALTTITALVVLRNGRRATGAGCALVGLLQLLITLFVTVKAAPDVSVLLSSLQYTRLGTVLFLGSMVTLTVAGFQRLRYAQPAREPNLVAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9G0</accession>
    <name>A0A231H9G0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DevR (DosR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">devR_3</name>
        <name evidence="5" type="ORF">B7C42_02491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45366">
        <property type="protein sequence ID" value="OXR45366"/>
        <property type="gene ID" value="B7C42_02491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="23711" checksum="DBC8EB455B37BA90" modified="2017-10-25" version="1">MTIRVFLVDDHAVFRSGVRAELSREADMDVVGEAGTVAEAVAGIDAVRPDVVLLDVHMPDGGGVAVLQGIDDRPNGSASGNGPVCLALSVSDAAEDVIAVIRAGARGYVTKTISGSELAEGIRRVAGGDAVFSPRLAGFVLDSFTGRSPAPEPPLDPELDSLTPRELEVLRLLARGYTYREIAETLFISVKTVETHASNVLRKTQQSNRNALTRWAHRRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9I4</accession>
    <name>A0A231H9I4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ESX-3 secretion system protein EccC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eccC3_2</name>
        <name evidence="7" type="ORF">B7C42_02587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45462">
        <property type="protein sequence ID" value="OXR45462"/>
        <property type="gene ID" value="B7C42_02587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="461"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="838"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="1142"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="484"/>
            <end position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="857"/>
            <end position="864"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1159"/>
            <end position="1166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1360" mass="147845" checksum="AD229CC2C259B905" modified="2017-10-25" version="1">MSTDGFVRRPRIAPPRAPGGEVALTAPPEIPRPVPPALLMRLMPVVMVVAVVGMIAMMVMMGRNLLANPFMLMFPMMMLMSMVGMMAGMRGSGGPKRAAELNEERKDYFRYLDQVRRDVRKTGGAQLQSLIWSHPEPADLRAVAGTRRMWERRPNDPDFGHVRVGVGSHRLATKLARPETGPLEDLEPVSTVALRRFVRTHSVVHGLPTALSLRAFPAINIEGRPDETRMLVRAMLMEYVTFHGPDHAAVAIICADPDAEAWSWAKWLPHLQHPVDRDGMGAARMMYRSLAELETSMAAELLERGRFMRNAQPTAGRIHLLVIIDDGYVSGTERIVSDAGLDSVTVLDLTAPQAGLAVRRGLQLVVADGTVAARSAAGVEQFAASDPVTIAEAQTLARALARYRVATAAQIVSLGDESRAVPGLMELLKIPDAAQIDPASVWRPRNDRERLRVPIGITPDGTPVEIDIKESAENGMGPHGLCIGATGSGKSEFLRTLVLSMVTTHSPDQLNMVLVDFKGGATFLGLESLAHVAAVITNLEEEIALVDRMKDALSGEMTRRQELLRSAGNFANVTEYERARAAGAALDPLPALFIIVDEFSELLSQKPDFADLFVMIGRLGRSLRVHLLLASQRLEENKLRGLDSHLSYRIGLRTFSANESRAVLGITDAYHLPSVPGSGYLKSDADDPLRFNACYVSGAYESPAGNAPGRTGGGQRGGGQEPVVFTAAPVPVRTPAAAAPARGPLGRPELPPPPGSPEAELELPPGAPADTVPKTLLNVVVDRLRGHGRPAHEVWLPPLDESPSVDMLLPDPDWRSPVNRHGRLWWPIGVIDKPYEQRRDVLIVDLSAGQGNLAVVGGPQSGKSTTLRSIIMAAAATHTPEQVQFYCLDFGGGTLAGLADIPHVGSVAGRMDIDRVRRTVAEMVTLLHQREERFRELGIESVHEFRRRKAELAQRSPAERAADPLSQDLFGDVFLVVDGWATIRAEFDVLEPAFNALAAQGLSYGIHLMIGATRWGEIRPAVKDLVGTRLELRLGDPSDSEMDRRTAVLVPVGRPGRGLTPEKLHMLIALPRLDSDSDPATLSDGIALARSQFAELYGDRRAPAVRMLPLRVPREQVLAEAAQRGIECSATRVVVGLGENELAPLVMDFDAQPHLMAFADVECGKTTLLRNIVLGITENSTAEQARVILIDYRRTMLGVLEGQQLAGYSTSGQTSFDMIKEVAAYLRQRIPGSDITPQQLRDRSWWTGPEIYIVVDDYDMVATGAGNPLEPLLEFIPQARDIGMHLIVARRSGGASRALYDKVLGMMKDLSVDALLMSAPKDEGKLLGDVRSAKLAPGRGTLVSRARENEMVQVSYLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9J0</accession>
    <name>A0A231H9J0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776478.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45525">
        <property type="protein sequence ID" value="OXR45525"/>
        <property type="gene ID" value="B7C42_02650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="160" mass="18077" checksum="C22DAF6355FBFA87" modified="2017-10-25" version="1">MSDAEQMGFDIEFDEKTQAFLDWVAPQRMESQVRSFLSNTVPGIADYEDPWWKPAVLTRVLDATLELFGDWDTFSTPENRDRADQFVRFLGECCVKQHPGMAWTNDPGSGAPLYTDFGPAVHFVDSGLGENVISLARELFMENYGPRMVEYSIQKAGVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9R2</accession>
    <name>A0A231H9R2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxybenzoate 6-hydroxylase 1</fullName>
            <ecNumber evidence="2">1.14.13.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xlnD_1</name>
        <name evidence="2" type="ORF">B7C42_02667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.24" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45542">
        <property type="protein sequence ID" value="OXR45542"/>
        <property type="gene ID" value="B7C42_02667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018669">
        <property type="term" value="F:3-hydroxybenzoate 6-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="437" mass="46366" checksum="79CF6551428D24BA" modified="2017-10-25" version="1">MRVVIAGAGIAGLTAAACLHRVGIDAVVFDAVTELRPLGVGINLLPHAVRELTELGIGAALADCAIATSRTLHLDRFGNRIWSEARGLAAGHHWPQYAVHRGELQELLVELVRARLGADAVREGLALHSFTEDADGVRCRFRDRSAGTFVEETADVLIGADGLHSAVRAQLHPAEGPPLWNGIRMWRGVSEIRPFLDGRTMVVAGSNHAAKFVMYPISGAAHRRGSSLVNWVAEVRGHDAAAQSPDWNRAGRLADVLPHYDGWRLAGVDISALLRGSAEVLEYPMVDRDPLPHWGTGRVTIVGDAAHPMYPVGSNGGSQAILDAGVLASELAAAADPIAGLTRYQQVRRTAVNAIVLANRDMPMDRVLHAVAQRAPLGFDRIEEVLTAAELAGLAEAYRHASAAVPVDLASDTAAAATTYAAGASADDDRPYDSGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9X8</accession>
    <name>A0A231H9X8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45668">
        <property type="protein sequence ID" value="OXR45668"/>
        <property type="gene ID" value="B7C42_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19923" checksum="2744CDA286CFA5F0" modified="2017-10-25" version="1">MSDYGEVVEPGTVRIERLLPGPIERVWAYLTDVDKRATWLAGGLLEQATGGRVEHLFRIHELTGEGDPAEVADRRHGEVLEWEPPHRLRHTWSTGGGLADSDVTFALEQVADKVRLTVIHRRIPTRGEILDIAAGWHTHLDILDARLASSPPDAFWSKFHSLRAEYESLIATESPDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA10</accession>
    <name>A0A231HA10_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator NanR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nanR</name>
        <name evidence="5" type="ORF">B7C42_02086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45794">
        <property type="protein sequence ID" value="OXR45794"/>
        <property type="gene ID" value="B7C42_02086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="30926" checksum="A1E4CE9565CF2DFF" modified="2017-10-25" version="1">MVSTGWLESVHGPKAARVTTARRGRIPQRRIAETVASELRTRILSGDDDYRLPTQDQLVKEFGVSYPSIRESLRILETEGLVTVRRGNVGGAEVHRPDETSAAYHLGLALQGARVTLGDLAAALQMLEPLCAAECARRPDRAEVVVPALEANIHACELVVGDGVAFTRTAREFHDLVVAFTPNATVRCVVSSLVTLWSAQEQAWAETLTRRGEYPSKPQAHDAARVHARLVTAIADGDDAEAERLARAHLRATQSVVLERYDSGMVNASSDLARQAIAAGPRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA52</accession>
    <name>A0A231HA52_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45740">
        <property type="protein sequence ID" value="OXR45740"/>
        <property type="gene ID" value="B7C42_02032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="13517" checksum="054D69DE770ECA2E" modified="2017-10-25" version="1">MAGITLGDGVGRRHMLLAASAGAVAASVFALAVALGIGLHPSAPLDSTPAGHGVAAGAVAFALVVGIPMAVTAGGALTGDRRVATAAVISGLLLICWLLAEMTVFRALDWAQPLYLVLGIVVAALGLHIKTEEIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA84</accession>
    <name>A0A231HA84_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782423.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45863">
        <property type="protein sequence ID" value="OXR45863"/>
        <property type="gene ID" value="B7C42_02155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="100"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="393" mass="44877" checksum="00B59341FA9A26EF" modified="2017-10-25" version="1">MTKIELPYQLFDADNHLYETKEALTRHLPKEFEGAIQYVELGGRTKIAVLGQISEYIPNPTFEVVARPGAMEEYFKNGNPEGKSRREIFGKPMRSIPAFHEPGPRLELMNELQLDRTLMFPTLASLIEERMRHHPDLIHAVVHSLNQWLLEEWGFTYKDRIFTVPVVSLPIVEKAIEELDWCVEHGAKAILVRPAPVPGLRGPRSFALPEFDPFWKRVVEHDVLVTMHSSDSGYSRFNAEWEGSNLEMLPFKTNTFRMTTEWRPIQDAVASWVCHGALFRHPELKVAVIENGASWLAPLLENLHDVYKKAPEGFGFQDPVEAVKRSIHVSPFWEEDLQAIAELIGVENVLFGSDYPHPEGLAEPARYINEIKDMPLADQEKIMGGNLARLLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAD9</accession>
    <name>A0A231HAD9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45830">
        <property type="protein sequence ID" value="OXR45830"/>
        <property type="gene ID" value="B7C42_02122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="61"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="35312" checksum="4D259C0334FD2CE3" modified="2017-10-25" version="1">MTVEAPRSAALVPAASSERGIAGHRAGGLEPPGVPEQVVTEADGIAVSGLLLRAREPRAVLVALHGGATTAAYFDCPGHPELSLLRVAAELGFTVLALDRPGYGASAPFTDRLWDPQRRVDLMYSAVTQLVPDAGRGAGTFVIAHSAGCELALRMAADPRGAALLGIELAGTGREFAAAARQVLMGPRGPVERPRGLADLLWRPASLYPPDVVGGAALAAVGPRLEAAAVTDWADTEFPALAARIRIPVRFTLGDHERVWRNDSDAMTQVGATFTAASRVVLNRQPGSGHNLSVGRSARAYHLGVLGFAEECLLAAKDGFDCLPDQFDGPEPFRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ1</accession>
    <name>A0A231HAQ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45915">
        <property type="protein sequence ID" value="OXR45915"/>
        <property type="gene ID" value="B7C42_02207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="155" mass="16693" checksum="15BB0D21BA31007B" modified="2017-10-25" version="1">MNDAGRQVPGHTRSRPKPRHPAPPLSGRLVAESRDTISVRVAEGIWTLDRDDVLQLRDESPDSGAAERAVLVWIRPGATADFTQRRRIQLTERPLTLPPRPTPAVGDELLARLTDQWARKLDVAPAPGAAGATVSYSQTRSGGGSDDGIACDSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB18</accession>
    <name>A0A231HB18_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">def_1</name>
        <name evidence="2" type="synonym">def</name>
        <name evidence="4" type="ORF">B7C42_01014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781348.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46051">
        <property type="protein sequence ID" value="OXR46051"/>
        <property type="gene ID" value="B7C42_01014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="21164" checksum="5F0C8B0BB0284E41" modified="2017-10-25" version="1">MAILPIRIVGDPVLHNPTQQVSQSPAELAGLIADMYETLDAANGVGLAANQVGESLRLFVYDCPDVQPDGSVQRRRGTVINPVLETSEIPETMPDPDDDEEGCLSVPGEQFPTGRANWARVTGTDEHGEPVTIEGEGFFARMLQHEVGHLDGFLYVDVLIGRNARAAKKAIKRNGWGTPGLSWVPGEVPDPFGHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB87</accession>
    <name>A0A231HB87_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase PknG</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pknG_1</name>
        <name evidence="7" type="ORF">B7C42_01053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46089">
        <property type="protein sequence ID" value="OXR46089"/>
        <property type="gene ID" value="B7C42_01053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031634">
        <property type="entry name" value="PknG_rubred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031636">
        <property type="entry name" value="PknG_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16919">
        <property type="entry name" value="PknG_rubred"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16918">
        <property type="entry name" value="PknG_TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="192"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="830" mass="89231" checksum="93AAC3262F6FAC7E" modified="2017-10-25" version="1">MSEHHDFPESEYPPTSLTPTPEPGEDPTTPQARHAPEPPEPRRTPGPRQIHGTQHIHGTQRADLPTAATPFTGPDTAAAPAGTGGPGTSSYPSEPSRPTGRSGRTVRSRPTVRRLGAGLVPIPAVPQLDPMGAVLADPVVAEGRRYCWRCGRPVGRTTAAHAATAVGSCDNCGAPYDFRPYLRAGDRVAGQYEIQGCIAHGGLGWIYLAIDRNVSDRWVVLKGLLHGGDAEAQAVAVAERQYLAELAHPSIVKIHNFVEHPGPGGSPIGYIVMEYVGGRSLRDLLDTHPRPERMPVPEAIAYILEILPALEYLHALELAYNDLKPDNIMVTEDQVKLIDLGATAPFDSYGNLYGTKGFQAPEIATTGPTAATDIYTVGRTLAVLTVNIPMVAGRYTDGIPHPDAEPVLARYESLHRLLLTATDPDPDRRFPSARVMTTQLAGVLREILAAETGTEHPQLSTLFSPPRTSFGTDELIGQTDVYADGVVRGKNLTARDIAAALPVPLIDPADPSAALLAGTAHSEPEHALDAVRAARRRAETAPDGAPDSFAAEATLAEVRVHLDLDQPAAARELLDNLGEQDWRTDWFQGLIALREQDYERAYDSFDAVLCALPGEIAPKLAIAATAELVLQQWDSPDPAQWRQCAEKFYATVWRTDRGVVSAAFGLARQLAADGRVAAAVAALDDVPSASRHYTEARLTAVLLLLTARPAEPGDPDSGDGETQQHAQVDTDRLEESTLHVAAARLQALPAAERRVAQLRVLVLGTALAWLQAGHRPRTSSSTLLGQPFTERGLRRGIESGLRALARTAPGRTHRYALVDLANAIRAKSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB88</accession>
    <name>A0A231HB88_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46204">
        <property type="protein sequence ID" value="OXR46204"/>
        <property type="gene ID" value="B7C42_01169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21768" checksum="62481215550039E3" modified="2017-10-25" version="1">MSLDGGKPRVAAKNSRDRGVEGVVVTTSVPVRLEHAKDIHPGVDVPLLRDAVVAERTLWTPAELHELTAVVASELATPLLDIVRFDTERRWWTRLALTMGVELWLLSWAPGQGTEPHDHGGASGSFTVSIGELDEDYRYPAGPVRSAARRAGDTIAFGPERAHQLHNRSARPATTVHAYSPPLRPVREYRSLRDFTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBG5</accession>
    <name>A0A231HBG5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hmgA_1</name>
        <name evidence="5" type="ORF">B7C42_01020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46057">
        <property type="protein sequence ID" value="OXR46057"/>
        <property type="gene ID" value="B7C42_01020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="44674" checksum="6F985A1D537B923F" modified="2017-10-25" version="1">MAFYRQLGSLPPKRHTQHRDDRGRLLYEELMGEEGFTGDSSLLYHRGLPPAIVDSSAWRPPNSRTVPNHPLRHRHLRLHDLFPDAVLAQTDVVTGRRLILGNDDVRISYVAALRESPLYRNAIGDELVYVEAGSGVVDTVFGRLPVRAGDHVLLPRATTHRWRPDGPEPLRGYIVEATGHITAPKRYLSAFGQFLENSPYCERDLHGPAEPLQESGTEVEVLVKHRPGAEILGTRMIYADHPFDVVGWDGCLYPYRFNIADFEPITGRIHQPPPVHQAFAGTNFVICDFVPRKVDYHPLSIPVPYYHSNVDSDEILFYCGGNYEARRGSGIGPGSVSVHPGGYAHGPQPGAYERSIGVEFFDELAVMVDTFRPLGLGEGALACEDPDYAWTWSGHGPSSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBY3</accession>
    <name>A0A231HBY3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_01295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46329">
        <property type="protein sequence ID" value="OXR46329"/>
        <property type="gene ID" value="B7C42_01295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="541" mass="59349" checksum="E27ADC2027CE242E" modified="2017-10-25" version="1">MRRDKPSRTDSMTAQLSSTIGGPVGDHALIGRSRFWTPLRILLAFAVVFLALGWAGKAGCIQQTTTSEGHLTLDWNNGRQYVAMCYSDTVPLYGAEHLDEGAFPYKKKWTEVGPDGKLQTRYMEYPVLSGLYQYLAMEVANIWMSLPLPKALSVVVYFNVVAVGLALAWLVTVWASAMLAGRRIWDAALVALSPLVLVHIFTNFDALATAFAATGLLAWARRRPVLAGILLGLGGAAKLYPLLLLGPIVVLCLRVDGRDRLPGLREQLRRNGNNAIGALRDYLAGARISPLRAALVTVVSAMLAWLAVNLPIAVPFTEGWWEFFRLNSERHADPDSLYNVITSFTGWQGFDGPLASSDTPTALNSVSLVLFAAACAVIGYIALTAARRPRVAQLAFLVVAAFLLTNKVWSPQYSLWLVPLAVLALPHRRILLAWMTIDALVWFPRMYYYLGTDDKGVPEQWFTSAVLIRDVAVVGLCALVVRQIYRPDQDLVRADGVDDPVGGILDRAQDPALPWLPSALQPRPPYPASGANSRSWARIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC38</accession>
    <name>A0A231HC38_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46503">
        <property type="protein sequence ID" value="OXR46503"/>
        <property type="gene ID" value="B7C42_01473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7158" checksum="F187360D20EB48AC" modified="2017-10-25" version="1">MPIEDEVIRLGQFLKLANLIDSGSEAKTVIAAGLVRVNDEVELRRGRQLHAGDVVALAGHRVRVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC79</accession>
    <name>A0A231HC79_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46544">
        <property type="protein sequence ID" value="OXR46544"/>
        <property type="gene ID" value="B7C42_01514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="28973" checksum="1ACB3B32A4469B0A" modified="2017-10-25" version="1">MTTGKTWFITGASRGLGRAFTEAALQAGDRVVATARDVEPLRDLGAAHPDRLIPLRLDVSDRRAVFEVVARAVALVGELDVVVNNAGGMLYGMVEEASEDQIRAHLDVNFFGAVWVVQAVLPQLRAQGHGRILQVTSMGTAGGMAAVGYYGAGKSALASLTEALAMEAEPFGIKVTNLEMGGYDTGLFTAGTTATEALPQYEPLREELARMWGDESGPAPSSAAPVIMKLVELEDPPRRLIVGGNSFDQVADLFAARAEGYRAWESLSRLAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCM2</accession>
    <name>A0A231HCM2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="3">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ssuD_1</name>
        <name evidence="3" type="ORF">B7C42_01550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497022.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46579">
        <property type="protein sequence ID" value="OXR46579"/>
        <property type="gene ID" value="B7C42_01550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019923">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03621">
        <property type="entry name" value="F420_MSMEG_2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="36829" checksum="3BB93868AE5653CD" modified="2017-10-25" version="1">MTEAAAAGATSGVEMTALGVPARAFRFAAAGEGNQQEGGARKFVKLAQQAEEYGYDSFAIPDHLGPQVGPIAALGALAVATDRIRIGTSVLANGFRHPVVLAKDAATIDVLSRGRLELGVGAGWIKSEFDAAGLPYESPGVRLEKLDEALTILDVLLRGQECHFEGKHYQVRGIKGTPRPRQGPRPPLVTGGGGPKMLRLAAKHADIISVVPRTTKTGKGLLSGITLEKTIEKVNLIKEAAGDRFPEIELNWTVTAVVITDDRERTAEMALAALDKGLHPDLEVDVQLSVEDILNSPYVAIGTFEEIAEQIRNVRRLTSMSYVGVFPTQMDAFAPVIPLLREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCR4</accession>
    <name>A0A231HCR4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Riboflavin biosynthesis protein RibD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ribD_1</name>
        <name evidence="2" type="ORF">B7C42_01446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46477">
        <property type="protein sequence ID" value="OXR46477"/>
        <property type="gene ID" value="B7C42_01446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="18101" checksum="B5CB5170A951AE4A" modified="2017-10-25" version="1">MTTESDAWESVESASRVPGRPGAHRFWMHHAIGLARLCPPSATAFSVGAVIVGPDGVELAHGYSRETEPKVHAEESALNKLGADPRLAQATLYSTLEPCSTRASVGRAPCADRILAAGIPRVVIAWREPRTFVENCVGVENLRDHGVEVIELPDLADEAMSMNRHLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCS6</accession>
    <name>A0A231HCS6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator SlyA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">slyA_2</name>
        <name evidence="3" type="ORF">B7C42_01567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46596">
        <property type="protein sequence ID" value="OXR46596"/>
        <property type="gene ID" value="B7C42_01567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="55"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18035" checksum="4B625DBF563EEF02" modified="2017-10-25" version="1">MAKASTAFPAHSTDAVTPDTALSAGLPSVAPSDTDTGCPVPTARNDGPGGLVGEWRDLLARHAAVSCALEKDLQREHHIGLSEFETLDRLVDASCDSYRMSDLAHDIHLSQSALSRTVARLERDGLVDRTLCTEDRRAIYVCLTDKGRAVHTAAVPTHRDVLERTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCT9</accession>
    <name>A0A231HCT9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_01707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46730">
        <property type="protein sequence ID" value="OXR46730"/>
        <property type="gene ID" value="B7C42_01707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="394"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="427"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="648" mass="70616" checksum="AAE2D8BE25F8BA2F" modified="2017-10-25" version="1">MRPGGPMPGAPGQKAKSFGPTLKRLLRRLAPDRVAVIAILVLAVASVVMNTLGPQILGKATNLIFDGVVSKQLPAGLTKDQAVASLRAQGQDRLADMMSSMNINPGHGVDFGAVGQVLTWVLVLYVLAALFNWLQAYLLATVINRAVQRLRSEVEDKIHRLPLSYFDTNARGDVLSRVTNDVDNVAQSLQQTMSQLVISVLSVIGILIMMFWISSLLAVIALLTVPAAVIVTAQIAKRSKPHFVDQWKYTGLVNAQVEEAFTGHEVVTAFGRIREVGEEFDKRNDKLYQASFKAQFISGLIMPVMMFIGNLNYVLIAVVGGLRVASGSLSLGEVQAFIQYSRQFSQPLTQIGSMINLLQSGVASAERIFEILDADEQVPDPREEDPRPIDRGRVEFDAVSFRYEPDKPVIDDLSLVAEPGHVVAIVGPTGAGKTTLVNLLERFYELDSGAITIDGVDITGIGRARLRSRIGMVLQDTWLFGGTIRENIAYGNPEASEEEILAAARAAYVDRFVHSLPLGYDTVIDEEGSGVSAGEKQLITIARAFLAKPTILILDEATSSVDTRTELLVQQAMAALRRDRTSFVIAHRLSTIRDADLIVVMEGGHIVEQGTHERLLAARGAYFRLYNAQFTGAAVDQDLVDEETVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDC9</accession>
    <name>A0A231HDC9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative succinate-semialdehyde dehydrogenase [NADP(+)] 2</fullName>
            <ecNumber evidence="5">1.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gabD2_1</name>
        <name evidence="5" type="ORF">B7C42_00046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.79" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46931">
        <property type="protein sequence ID" value="OXR46931"/>
        <property type="gene ID" value="B7C42_00046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="523" mass="56285" checksum="0CD2730B1FF11F51" modified="2017-10-25" version="1">MTAGTTDQADGSGVLQASGGIIEVRCPADGRIVGRVPDLGAAGVQAAAKQLRAAQPAWEALGPEGRAKHMRNFLDWILDNEANLVGIMQEESGKSWGDAALEVSMAVDLINYYSGHAAEFLADRKVPSWGASGLTKKLRVFARPHQLVGMITPWNGPLGGPMLDGVAALMAGAAVLFKPSEVTPLTWAEATRGWLEDLGAPPVLANVTGGPEAGAAVVDEVDMIMFTGSTRTGRKIAARAGERLIPCSLELGGKDPMVVLSDADIDRASSAAAWGGMWNSGQICISVERVYVEAPVYDEFVAKVTDKVKNLRQGMDPDGSFTTDIGAMCTPAQLDIVEKHVNDAVAKGARVLTGGKRAEDGQFFEPTVLVDVDHSMLCMRDETFGPTLPIMKVDSEQEAVRLANDSRYGLSASVWSRSRSRADRIARQIEAGAVNVNNVMMSTFQLTIPMSGWKESGVGSRSGGAAGMLKFCRQQSVVSERIHLRSEPHWYPYVPKKSELQAKMVRFLGAHDWRRRLGRTPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDE0</accession>
    <name>A0A231HDE0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodocoxin reductase</fullName>
            <ecNumber evidence="4">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thcD_1</name>
        <name evidence="4" type="ORF">B7C42_00089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46973">
        <property type="protein sequence ID" value="OXR46973"/>
        <property type="gene ID" value="B7C42_00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="3">
        <location>
            <begin position="323"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="44444" checksum="323C2FAC6910A367" modified="2017-10-25" version="1">MVRPTVVVAGAGQAGTQTAASLREFGFDGNIVLVGDEPHLPYQRPPLSKGHITGKAARDTLWLHPATFYDHHEIDRYIPDRVRTIERAAGRVELASGTTLGYDHLVLALGARNRTLPLDGADLDGVVGLRTLAEADDLRERLARARNVVVVGGGFIGLEVAAAAVALGLRTVVIEVADRLMGRVLSPPMADFLLDAHRARGLQVELGTTVERITGTSGRVTAVATADGRKFPADVVLVGIGALPNTELAEAAGLPIANGIVVDQFLRTADPRISAVGDCASCPNPFAGGRRIRLESVHNATAQPRALAARIVGRPEPYHSVPWFWSDQSDMKLQIAGLTTATSEFVFRGDPGSGRFSIFCFDDGRLQSVESLSRPGDHMAARKLLAIEDCLSPEQAADAEFDLRTHLSSLATAAKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDH1</accession>
    <name>A0A231HDH1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA_2</name>
        <name evidence="6" type="ORF">B7C42_01755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775432.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46777">
        <property type="protein sequence ID" value="OXR46777"/>
        <property type="gene ID" value="B7C42_01755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="15"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="448"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="900" mass="96975" checksum="EBC098F00A1E770E" modified="2017-10-25" version="1">MKIPELSDTVRLDCDVLVIGGGTAGTMAALTAAENGANVLLLEKAHVRHSGALAMGMDGVNNAVIPGKAEPEDYVAEITRANDGIVNQRTVYQTATRGFAMVQRLERYGVKFEKDAYGEYAVRRVHRSGSYVLPMPEGKDVKKALYRVLRQRKMRERIRIENRLMPVRVLTDNGRAVGAAALNTRTGEFVAVGAKAVILATGPCGRLGLPASGYLYGTYENPTNAGDGYAMAYHAGAELSGIECFQINPLIKDYNGPACAYVANPFGGYQVNAAGERFVDSDYWSGQMMAEVKREIESARGPIYLKVSHLPEETLDALEGILHTTERPTRGTFHANRGHDYRTHDIEMHISEIGLCSGHSASGVWVDEHARTTVPGLYAAGDLACVPHNYMIGAFVYGDLAGEHASSTLPEVAAPQSLPSDQLAAAHELIYRPLRHPDGPPQQQVEYKLRRFVNDYVAPPKTQTKLSLAVETFERMRQEIAEMGADTPHQLMRCAEVDFIRDCAEMAARSSLTRTESRWGLYHDRADLPERNDEDWRYHLNLRKGADGEMEFLKRPVAPYFVPVPEWEDLPRADLEPVAVAQPELIAGPPRTAGASTGTAPRPGITIPAAADDSAAPRIAILLSLDGPTVAELRDYLDDTDPRVRATALSVLTEGTPDGFADSLIAALGDHDAAVRAAAVSGLRELIEILPPAEQLIAHAESPDPLVRAAVVDLLRAQRRGSADLFGKAVVDSDHRVRIEGVRALVSLDDWSALTAAAFDENREVRVAVARGLAEVGAGGADTVRALVGDRDPLVRAAALAALARLGDSSDAAILAAALKDSAWQVREGGARGWAGLGPESAAAALESALTDPHPDVRKASVLTLSHWPDHAAVRAALQVVLADTDADVRAYARRTLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDQ5</accession>
    <name>A0A231HDQ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_1</name>
        <name evidence="1" type="ORF">B7C42_00078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46962">
        <property type="protein sequence ID" value="OXR46962"/>
        <property type="gene ID" value="B7C42_00078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="26973" checksum="A03AAD0887EDBBFE" modified="2017-10-25" version="1">MEENVANPPGERTVLVAGGSGGIGSAICRALARDGFDIALTYHRNSEAAEKTADAIRDLGAKAWVHQLDLTDATATRALVRSVPRLDSVVYAAGPQIPMRYTVQIEPEQFAEQLRRDAVACFNLLQPAIEPLRASRGTIVCLVTTALLRYATRDLLSAAPKGAVEQVVRAIAAEEGKNGIRANCVGVGVIEAGLLDDLIASGEYSERALEAARRATPLRRFGSADELAAVVAFLAGPKASYVTGQTLRVDGGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDY8</accession>
    <name>A0A231HDY8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030512770.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47193">
        <property type="protein sequence ID" value="OXR47193"/>
        <property type="gene ID" value="B7C42_00315"/>
    </dbReference>
    <dbReference type="GeneID" id="66720956"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="16863" checksum="7FE8865C44F04D7F" modified="2017-10-25" version="1">MAKKFESPADWAPPGAQFQSRGVTSRTLSGVLFGLIVTPIGIAFAAKGGADIRYWVIVGAVTDRWTAALEIFGGSLLLLFVAAMAAFSPVGTIVASLVWGIFPGVLHLLYPDDTFRLIGDLPFTDATMQVALHSWVTYGFALISGMMLLGAGMVGVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE27</accession>
    <name>A0A231HE27_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mercuric reductase</fullName>
            <ecNumber evidence="6">1.16.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">merA</name>
        <name evidence="6" type="ORF">B7C42_00147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47028">
        <property type="protein sequence ID" value="OXR47028"/>
        <property type="gene ID" value="B7C42_00147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="347"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="461" mass="48333" checksum="7581BEEDA64C5EB1" modified="2017-10-25" version="1">MPAETPATESVDAVVIGMGPGGEAVATELARAGLAVVGVEGRLLGGECPYYACVPTKMMVRAAETLAEARRVGTLAGSAQVQADWAPVAKRIRDEATDNWDDKVAVERFESAGGTFVRGWGRITEPGQVRVDTADGPREFRALRAIVLNPGTAPSVPPIEGLADTPYWTNREAVTTTEAPESLIVLGGGPVGAEFAQIFARFGAEVTMVVRSRLLPRAEPEAAETLAKTFAEEGISVRTGVEATRIDHDGGYFTVRLSNGDPIRAQRLLVAAGRYTDLSALGVGALGLDEQAHGIRVDDRLRAAEGVWAIGDVTGHGAFTHMSMYQARIAAADILGSPGEPAQYHAVPNVTFTEPEVGAVGMTESQAREAGLSVWTGRAEVPDSTRGWIHGPGNAGFVKLVADADRGILVGATSVGPVGGEVLSALAVAVHARVPVTTLREMIYAYPTFHRVIEAALADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEK1</accession>
    <name>A0A231HEK1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Steroid Delta-isomerase</fullName>
            <ecNumber evidence="2">5.3.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ksi_1</name>
        <name evidence="2" type="ORF">B7C42_00267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030512726.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47145">
        <property type="protein sequence ID" value="OXR47145"/>
        <property type="gene ID" value="B7C42_00267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="13565" checksum="7BB7A920AC17CF3D" modified="2017-10-25" version="1">MAAQQIRETAERYVQLVATGPTSEILSLYAPDAVVEDPIGSDPRHGHEAIGQLYQALESMERKTELHAARIVGNHAAVSFTLVGEAGGHRMTLSAIDAMEFDEQGRITSMRAYWGPDDLISEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF65</accession>
    <name>A0A231HF65_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 16" type="primary">gpsA</name>
        <name evidence="16" type="ORF">B7C42_00583</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47458">
        <property type="protein sequence ID" value="OXR47458"/>
        <property type="gene ID" value="B7C42_00583"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="173"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="2"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR47458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="325" mass="33515" checksum="D2A6DB265E042936" modified="2017-10-25" version="1">MGAGSWGTAFAKVLNDAGTEVTMWARRPEIAKAVATEHRNPAYLPDVWLDGIAATDDYRVALDDADIVVLAVPSQSLRPNLAHWRAAIRSDATLLSLAKGIETGTLMRMSEVIAEVTGADPGRIAVLSGPNLAREIAAEQPAASVVACSDAARAEAVQHSCATGYFRPYTNTDVIGCEIGGACKNVIALACGIAAGMGLGDNSVASLITRGLAEIIRLGVALGANPVTLAGLAGVGDLVATCTSPLSRNRSFGHVLGAGGSMRAAQDATHGQVAEGVKSCTSIRALAETHHVEMPLTTAVHRVCHEGLSVSDAVGQLLGRRIKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF97</accession>
    <name>A0A231HF97_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease protein DppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dppB_1</name>
        <name evidence="7" type="ORF">B7C42_00677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47552">
        <property type="protein sequence ID" value="OXR47552"/>
        <property type="gene ID" value="B7C42_00677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="36287" checksum="1F7BE62A5ECBBA79" modified="2017-10-25" version="1">MTGQVVRILVHRIWTGALVLLGAVTLTFFALRLAPGNPVDTLLGAQTSASPRVRAQIAADLGLDQPVWRQYLHTVLRPLTGDLGRSYQLQEDVKSLLLSQLRPTAELALCALVPAVLVAVLAATSTAGRGRFVRAAVSGAELLAVSLPPFWLGLLLITAFAFRLHIFPVAGDHGAASLVLPALSLAVPMAGELGQVLRGNLDRTLEQPFVATLRARGLSEPGLRVRHALRHGSLATVTMTSWMLGTLFSGTVLVETLFARPGIGRITVNAVTTKDFPVVSAVVLLAAVLFVVINLVVDLLYLVLDPRLRAPRARPVRTPALAPASVAVSGAVVADAEPVGKGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFM4</accession>
    <name>A0A231HFM4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47618">
        <property type="protein sequence ID" value="OXR47618"/>
        <property type="gene ID" value="B7C42_00743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="16746" checksum="5C1D48B76ECDFC16" modified="2017-10-25" version="1">MSGFRVSRGTYQVLPGPALSSGRAWRARTRAGFVLAAGTLAGALLPIVGAAPAEATVAPTITVSMSGSALSPVSGALVGCAQNAVATVRNPDGSPVTHGTVDFFSHLSGISGNIVGTAPVVNGVASIGWMPDRPGEHVVSAVYYDGLPELSPVAGYTIVTTASLGGACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFP0</accession>
    <name>A0A231HFP0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47692">
        <property type="protein sequence ID" value="OXR47692"/>
        <property type="gene ID" value="B7C42_00817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="17359" checksum="62FA9DCD8A232B8A" modified="2017-10-25" version="1">MDTEITENRIRELLDRSEITDLLDRYLRSLDDGVFDDRWARTYFTEDATAEMPIGTVHGRDAVLAHIRRGMALFDRTVHLGTNAVIELDGDRATVRGAQLSTHVLADGSEAVFISAGHADTELVRTADGWRIRASSLRITWTQGTPPRLPAGLGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFS4</accession>
    <name>A0A231HFS4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bphB_1</name>
        <name evidence="1" type="ORF">B7C42_00958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.56" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779657.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47833">
        <property type="protein sequence ID" value="OXR47833"/>
        <property type="gene ID" value="B7C42_00958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018509">
        <property type="term" value="F:cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="27099" checksum="0A8152806244AD9A" modified="2017-10-25" version="1">MGALDGQVVVFTGAGAGIGRSVVTRYVAEGARVLAVDISDRVEDLPGELGTAVVPMVADVATWEGNLGAAQAALDRFGRIDVFVGNAGITDNAQPLEDIRGADLPAAFGELFGVNVLAPMLGVRACLESLIETRGSVILTGSFASTNAAGGGSLYTASKHAVHGLIRQLAYELAPDVRVNGVAPGVAPTRLRATASLGQVATDSVLDGTERALPTQEIAPISAYDGVFTMLASRTESVAMTGTLVTVDSGLSIRGIAKPGGRVNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG02</accession>
    <name>A0A231HG02_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">truB</name>
        <name evidence="9" type="ORF">B7C42_00771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779559.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47646">
        <property type="protein sequence ID" value="OXR47646"/>
        <property type="gene ID" value="B7C42_00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015225">
        <property type="entry name" value="tRNA_psdUridine_synth_fam2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09142">
        <property type="entry name" value="TruB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="33"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="8">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C" evidence="7">
        <location>
            <begin position="246"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="32384" checksum="CB701890A7EAB94D" modified="2017-10-25" version="1">MAGREAVVDPLGGLLIIDKDGGQTSHDVVARCRKILRTRKIGHAGTLDPMATGVLVLGVERATKLLGLLSLTTKSYTATVRLGQATVTDDAEGEVLATIPAAHIADADIAAAVAALTGDIAQVPSTVSAIKVNGERAYARARAGEQVELAARPVTVSRFDILGRRDIDTGATTFVDLDVEVDCSSGTYIRALARDLGTALGVGGHLTALRRTRVGPFTLEHARTLDQLADDPSLNLDVDAAVRLAFPHREIDADQAESLRDGRWLDPVGVRGVHAATTADGRTIALLEEKGKRSSPVFVVRPRGLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG16</accession>
    <name>A0A231HG16_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-(Hydroxymethyl)mycothiol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.306</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.306" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779534.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47666">
        <property type="protein sequence ID" value="OXR47666"/>
        <property type="gene ID" value="B7C42_00791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050607">
        <property type="term" value="F:mycothiol-dependent formaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="23"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="371" mass="38392" checksum="32658F8AE07B2A2F" modified="2017-10-25" version="1">MKIRGAVLERIGDPTPYADSTPIVIEDLELAEPGPGELLVRIEAAGLCHSDLSVVDGNRVRPVPMLLGHEAAGRVEQVGPGDSDLRVGQRVVMTFLPRCGQCEGCATDGRTPCIPGSVANNEGELLGGGRRLHDANGPVHHHLGVSGFATHAVVDRRSVVPVDDDVPPEVAAVLGCAVLTGGGALLNSARPGVGDRIMVVGLGGVGMAAVLVAASLRDSLGAEVIAVDTVPEKLTLAKELGATQVYTPAEVAERGIAAEVVVEAAGNVRAFETAVAATAPGGTTVTVGLPNPEARASISPLGLVAQGRSIVGSYLGSAVPARDIPEYVRMWREGRLPVERLVSSRIRLDEINHAMDELAAGHALRQVIIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGB8</accession>
    <name>A0A231HGB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ECF RNA polymerase sigma factor SigK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sigK_1</name>
        <name evidence="7" type="ORF">B7C42_00892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780032.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47767">
        <property type="protein sequence ID" value="OXR47767"/>
        <property type="gene ID" value="B7C42_00892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="22536" checksum="A2DECBAA641F5D15" modified="2017-10-25" version="1">MDIDQRYRQSSSTTITAAELATLLHKSAAGDAESFAAFYRSTNARLMARLTAILRSPGLAQEVSQEVYLQAWSAAGDYDAGRASPMAWLMMFAHRRAVDRVRSEQSLADRERAFGRGQYQPECDVVFDEVTQRLDERSVAGEVHRLGHRQREAILLAFYGGRTYPEVAQDLGIPLPTAKARIRAGLKTLGSRLSEKSRDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGI3</accession>
    <name>A0A231HGI3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
            <ecNumber evidence="3">3.5.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779660.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47827">
        <property type="protein sequence ID" value="OXR47827"/>
        <property type="gene ID" value="B7C42_00952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="31080" checksum="7072DCA3FF461142" modified="2017-10-25" version="1">MTARTLKVGLTQWHATTDMAANLATALRLIERAAAAGAQLVTLPENGLMLGTNVQMREAALHEDSDEVRRLRRAAATHGVAVVLGGMKNRTAEATYNSALVIDAAGALVGRYDKMHLFDARIGGRSFEASTVERPGAGPVLLEFDGIRIGLTICYDVRFPELSRALAVAGAEVLLVPAAFVQSTGAAHWHTLLRARAIENLAYVVAPATVHSPDPEFADAFATFGHALVVSPWGEVLADLGEDPEAVRVVELDLEAVTRARAGLPVLAGRRGAGEYDAAPRVLPLAGRGAEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSR9</accession>
    <name>A0A231GSR9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000096">
        <property type="protein sequence ID" value="OXR39666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39666">
        <property type="protein sequence ID" value="OXR39666"/>
        <property type="gene ID" value="B7C42_08271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="35" mass="3868" checksum="E790A1E9588511AC" modified="2017-10-25" version="1">MLRCLLAPLLHHPVITLEGHGPVYWTPIITAALYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GST3</accession>
    <name>A0A231GST3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000086">
        <property type="protein sequence ID" value="OXR39684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781980.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000086.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39684">
        <property type="protein sequence ID" value="OXR39684"/>
        <property type="gene ID" value="B7C42_08242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13329" checksum="6FE2FCF828BDBBC5" modified="2017-10-25" version="1">MDTPIIVRTFVPELDAIINLGLGLQHSFNLPVVDAIYNAIAVVSDNARDKGARDSDVYDAFHDGLTGTTTVSGNRDEVIVTAHLARALIYIDRLDSIMAVAAAFPAAVAAIATTPDTALPLDILRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT02</accession>
    <name>A0A231GT02_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000175">
        <property type="protein sequence ID" value="OXR39601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39601">
        <property type="protein sequence ID" value="OXR39601"/>
        <property type="gene ID" value="B7C42_08331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624270" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="10725" checksum="2767838AB35C8BFE" modified="2017-10-25" version="1">MSVARRSLGCGTRFTKWAASSRSTVLVTEVGCTCRRALATAIGSAPVLLKLSNISNSYREKVKPDGRRASSTRAITICWARTSDVTAAIPSATSPQPCSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT39</accession>
    <name>A0A231GT39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000073">
        <property type="protein sequence ID" value="OXR39748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39748">
        <property type="protein sequence ID" value="OXR39748"/>
        <property type="gene ID" value="B7C42_08177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="29134" checksum="97734784B4A0109E" modified="2017-10-25" version="1">MVFQRSRGVPGWCRRWCTRTAPVARIHERHVRDNNRNEAGRSRCRPRRPLRAATHFLDLARPGAVDHRSARRKCAGADRYSLPDHADRVVLAEFGDGGNLRRAVRLQTRRYLRQTPDDDHRHHPRPGGRPDLGSGAQLRCSPPRQGHQRLLYADGRACLRARTRRLSPESRRTGQRADQRCGRTGRTRRPVPVRLAARRLRLPRCVVVPGDCHGCQLGDAGGVRAGIAGAQQQYEFRLARRPAAGCRLDRHRLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTK5</accession>
    <name>A0A231GTK5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T5orf172 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39953">
        <property type="protein sequence ID" value="OXR39953"/>
        <property type="gene ID" value="B7C42_07960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025280">
        <property type="entry name" value="DUF4041"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13250">
        <property type="entry name" value="DUF4041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T5orf172" evidence="3">
        <location>
            <begin position="355"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="468" mass="54953" checksum="F8F58F65D7D0BFE9" modified="2017-10-25" version="1">MNSMPPADWYPDPNDNRFIRYWNGAEWTADRRPVVTGAGGQTEQRATQDLRVPLFGARAYARQQSQELSDLQVENHRLREQLERTGGLEIAAMRQLRDQLAAQITTEQAHLDELRAEIVNTRDEQMLQEIGIYEYHHPLSNSVHHRAELEDLQRQIKAMARQDGRAIVASTPWIVRDSVTEGRRMVKEYSKLMLRAYNAEADNLVRDLKPYKLPTALKRLDKAASTIDRLGRTMDLCIAPEYHRLRRRELELTATHLEEVAYQKQLEHEERDRQREERKAQQEMARERTRIDREMKRYRGVLAEYELAGKEDSSDAEEVRDKLKELDFRRQRTVYQSMHTAAGYLYVISNIGAFGEDRPMVQIGFTRRYHWQDRIRELSNTAVPFPFDVHVALHSDKAADIEAELHRRLADRRVNRVNQRREFFYATPAEVRAHLEDLTDVRLLEFTELAKAIDYRKSCALERNTTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTK6</accession>
    <name>A0A231GTK6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782350.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39908">
        <property type="protein sequence ID" value="OXR39908"/>
        <property type="gene ID" value="B7C42_08013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="6778" checksum="DA7246E6EDCC66DA" modified="2017-10-25" version="1">MADMTPAGRAARQLDAAAAELELVWSRNRCLPGRLTVLAGQIREATAILSAAVADAPPAAGPAPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTS7</accession>
    <name>A0A231GTS7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40019">
        <property type="protein sequence ID" value="OXR40019"/>
        <property type="gene ID" value="B7C42_07903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="588" mass="62676" checksum="49BCB69F26FD74A1" modified="2017-10-25" version="1">MTIHTGTRKARHLRTTAVTGIRVLTLQARAEVETVAAGRGLAAVRARWALSSDDHRRANAARKAEDSVSDGFAVPVTSSTDRGYRGVGGGRATVVPATPEWRATTVQVAGLWPFAVGATAPVVGCPVGSHFVTGAPVHFDPMSWFARGFITAPIAFVLALNGFGKSSLIRRLATGAVAAGETVLCMGDTKPDYRDLVEVLGGQVVDLGYGHGSINPLAVGALGTIIDQLPDTDQRRQVAARVEAGQVNIVAGLIELVRGSRVADYEETLIAAGLRELYSPAGGFTPQRPPRLSDLLATISGGAQRLRQFAEEDDDVAFRAATKVLRRSLRAVIEGPWGQIFDRHTSTPLDLNSPAVCIDVSRIPEGDTKLLAAVLMVCWSEGFGAVAAAHALADAGLAAPRTFEVVMDEIWRVLGAGEFMVDRVDALTRLNRPLGTGLIMCSHTIKDLAAFDSPAAQAKALGFFERARAKIIGPVGPEEIERLRAAVSITDTEKLLVTSWAAPRPPTDDHLDNTGVRETPPGTGCFLLKTGEADAPGIPFRMTFTPTERAHDIHNTNRRFSHLTREHNNSPRPSLKADASEAGEDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTT8</accession>
    <name>A0A231GTT8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39965">
        <property type="protein sequence ID" value="OXR39965"/>
        <property type="gene ID" value="B7C42_07972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="16754" checksum="0B0EDF4123FDC601" modified="2017-10-25" version="1">MRHQKAERTFPLSATDFGVARQLTYELSNVAQDELQAIGWTADTKQFLKNLMYSVSRELEEPKQVQLTIREIDNHTAAELNAKRRSAELNDPGAPITRTIPESIVNIWLTSLRIAWQHLGPLEGRYRTGYDEHEIENALAAVEVMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTZ3</accession>
    <name>A0A231GTZ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40048">
        <property type="protein sequence ID" value="OXR40048"/>
        <property type="gene ID" value="B7C42_07893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="469" mass="45396" checksum="AB0C01E629A4D36A" modified="2017-10-25" version="1">MTTTIAAVNHAQLPDIVCDLPTGPGAVCALKQLGGKAANSAANSAFDSMVDKLVDSLTSLIRVLMTWWVNLPSPQLAASTGEPGPALAAIRGYTSGLQVLLMIAGILFAAGRLAMAKRGGVAGEAQESFLMFARAVFASMMFSALITTGTKAGDAFSDWVINDATGGDLHGAVERLVDNNLRDHSNLGSGVLLVLAILGLISMLVQLAMLVIRQAVLILVVAAIPLAAAAAGTGPGSQAYKRMLSWSLAFVLWKPVGALVYAIAFTAAGTKTTGQQQDPQLVLLGMILLLSVTIVLPALMRLVAPAVATLGGGGGAGAALAGGALGIAMGAAGGDRSAARKMTEGENATTSGAGGGSPHPPPSGPPGGAGGGRPLSGGTGGGGASPGRGASSGGAAPAGAGGRSAGSAGSAGGSSGAAGGAGAGAGIAGAAVMGAQLAGQGVQSASSAVESQAGDSWDIDAPGPLEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUS8</accession>
    <name>A0A231GUS8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione transport system permease protein GsiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiC_6</name>
        <name evidence="7" type="ORF">B7C42_07549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40383">
        <property type="protein sequence ID" value="OXR40383"/>
        <property type="gene ID" value="B7C42_07549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="33622" checksum="B22562EA811882EA" modified="2017-10-25" version="1">MTSYAARRIAQAVVVLWAAFTLTFVVLYLLPSDPVSIQLGAAGIETDSLTPQQLTAAKAEYGLDRPILDQYISALTGALHGNFGTSIAKHMPVTQLIGDRLGGTLLLSILAGTLAVVVGTVVAYLAAFVRFRPLRTVLDRIPALGVAIPSFLVALLLIQVFAFNLGWVPSSGSAGWRSQVLPVVTMALPSSAQLAQVLTHSFDETLGEQYIVTARAKGLSRSAVQLRHAFRNALLPALTILGLLVGTTVTSAIVVETVFSRNGIGRLAQEAVLAKDIPVVLGIVVIAATGFVLVNLVVDLLYPLLDPRITHATKAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUX4</accession>
    <name>A0A231GUX4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydroanticapsin 7-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.385</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bacC_7</name>
        <name evidence="1" type="ORF">B7C42_07482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.385" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042667.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40424">
        <property type="protein sequence ID" value="OXR40424"/>
        <property type="gene ID" value="B7C42_07482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="29949" checksum="A31AB9854EBEE752" modified="2017-10-25" version="1">MTTNHAEELFGLTGAVALVTGGAGGIPKATALALAKAGADVAVVDIADEFTAQTVEEIQALGRRAIGLHADVRRRDDIEDMIEQTRQRLGPIAVAVNGVGSLGAAVPKSFLDFTVEDWNGPVELNLTSTMLCVQAEALAMIRDGMAGSIVTFGSTSGLVAAPSVAHYGAANAGVIHLTKSVALELAPYDIRINCVVPGTHNINRAGRETPTSSRPEQAEFLRKAAAATPQKHLGLAEETAGVALFLASKLSAYMTGHAVISDGGITHTTARPAVGTLEPAALRGLEVSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVD2</accession>
    <name>A0A231GVD2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514865.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40574">
        <property type="protein sequence ID" value="OXR40574"/>
        <property type="gene ID" value="B7C42_07383"/>
    </dbReference>
    <dbReference type="GeneID" id="66721354"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="13604" checksum="0C52A9D5C213E827" modified="2017-10-25" version="1">MANPNRSDVGWLLDDLVKGLTGVRYAVLLSTDGLLLGNSSELENSDAERFCAMASALHSLARSAGHHFDAGGVCQTMVELDRAVLFITAAGDNACLGLLAADNADLGMVAYAMNQTVQRVGSHLAVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVM4</accession>
    <name>A0A231GVM4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="6">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_07307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909796.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40622">
        <property type="protein sequence ID" value="OXR40622"/>
        <property type="gene ID" value="B7C42_07307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="532" mass="58971" checksum="94464D5E0566A9EE" modified="2017-10-25" version="1">MNKTRSAKNTRKTDGSANSGAQARVHRTEVLIVGSGFSGMGMAIQLLKAGIDDFLMIEKEDEVGGTWRDNTYPGCACDVPSHMYSYSFEPKPDWSYLWAGQEEIQEYLRGIAQKYDLYRRTHFGRTLQSGYWDAGDSTWHLVTSDGHEYVSRFLVSGVGALHIPSIPEITGQKKFSGDVFHSAQWDHEVSLRGKRVAVVGTGASAIQFVPEIAKVAAELHVYQRTPAWVLPRRNIKIPRPVRAAFTHAPILAKALRAAVYWSAESLSIGLNGHFNLMRPLENIAKWNIAQGIDDPALRAKLTPTYRIGCKRILGSSEYYPALNRPTTTVITDGIAEITEDAIVSRTGETRPADVIIYATGFHVTDGFESLRLKGASGRELASVWADEGIQTHLGITTAGFPNLFFLLGPNTGLGHNSVVFMIECQIRYIVSAIRLANERGSGALEVREPVQHQFNNDIQRKLVKGVWSSGGCTSWYLDAQGVNRTVWPGFTWQYWRRTRKLAAADFAFFGERSVARRGTAIASESGKENQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVT2</accession>
    <name>A0A231GVT2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fdxA_2</name>
        <name evidence="9" type="ORF">B7C42_07390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514872.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40581">
        <property type="protein sequence ID" value="OXR40581"/>
        <property type="gene ID" value="B7C42_07390"/>
    </dbReference>
    <dbReference type="GeneID" id="66721347"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="11752" checksum="0B0048E999F27779" modified="2017-10-25" version="1">MPYIIAEPCVDVKDKACIEECPVDCIYEGNRMLYIQPDECVDCGACEPVCPVEAIFYEDDTPDQWSGYINANVDFFDDLGSPGGATKVGKTDYDVPFIAALPPMANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW11</accession>
    <name>A0A231GW11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripeptidyl aminopeptidase</fullName>
            <ecNumber evidence="3">3.4.14.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tap_3</name>
        <name evidence="3" type="ORF">B7C42_07069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40786">
        <property type="protein sequence ID" value="OXR40786"/>
        <property type="gene ID" value="B7C42_07069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012782400" evidence="1">
        <location>
            <begin position="24"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="93"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="501" mass="53912" checksum="A05C8B154F77DCB9" modified="2017-10-25" version="1">MSRVFRWGAAVLAVAAVLVTSGAAVPSPVTGMDRFYRQQPKWKPCAVETLDAAGGSCAAVRVPLDYADPDGRTLNIAISRVPATDPDRRRGVLLADPGGPGASGLDTVDLLGDVLAPEVRAQYDLIGMDPRGVGRSDGGRTCGWPIGEMIRSAGVGPDGFLTDTARAARLAMACLTGDSASLRQLTTRNTARDMEVIRRALGQPSLSYYGVSYGTYLGAVFAQLFPRSVDRMVLDSAIDPDRYWNGMVHDWGAADEAALDDWAGWAARRDPDYHFGTTAAQVRGAVEQLMNDIARQPITVNDFVIDDHWLPFLLHNLLGNFRLNVKMADTVAGLRAATGATPPAGYTPWLTDTLDSLRQYEDSALAFVACGDDAAPEDPVRYWSEIEQRRATQPIFGALAANIQPCAFWPRPVESVTTVRNSVPALIVQATGDPRTPYDHALALHRDLSASRLVTLADVRIHMTFRPGLSRCVGAAINGYFADGVFPATDVVCAPDTEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW73</accession>
    <name>A0A231GW73_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-aminoadipate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysN_2</name>
        <name evidence="3" type="ORF">B7C42_07015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.39" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40880">
        <property type="protein sequence ID" value="OXR40880"/>
        <property type="gene ID" value="B7C42_07015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="71"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="401" mass="42828" checksum="C0C30C0B0F35D673" modified="2017-10-25" version="1">MTDTGTTIFDTHSVLSRRGAHESPLGGFGPAATAVAPDAIRLLGGVPADEALPAQRLREAFDSALGEGSSSVAALQYSTATGIEQLRDRLARHEDTVPDRVLITNGALHGLSLLFNAVLDPGDTVVVESPTFPLALRLLGHYGAHVVPVQVTTGGLDLNGLEERLRAGLRPKLLYLIPDFQNPTGSALPAVDRLRVVALAEQYGFLVVSDNPYRELRFAGEAVADLSLDSDAVVRVNTFSKTLGPGLRLGWLAAPRWLLPVLTRLRSNTDQHSALVTQTAVAALLARPGEFDAIVAAARAIYRERATALTGALRETLAGAIEFAEPEGGIFLWARATDPDIDLALVQARARTLGTDFALGRYFDPDGAAGYTHHLRLGFSNNSVPRIRTAVQRLAKAFETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWM6</accession>
    <name>A0A231GWM6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">K(+)/H(+) antiporter subunit KhtT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">khtT</name>
        <name evidence="3" type="ORF">B7C42_06941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517228.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40975">
        <property type="protein sequence ID" value="OXR40975"/>
        <property type="gene ID" value="B7C42_06941"/>
    </dbReference>
    <dbReference type="GeneID" id="66723701"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="160" mass="16940" checksum="0CB82D216CDA5936" modified="2017-10-25" version="1">MNVDVTQLPGIGVRKDFEARSGRRIGVVAHRDGGIDLIVSKHDDPDDCAAQVPLTVDEAAVLANLLGAPQLVEKLKDDHRDLPGITTRQLPIGDESPYSGRALGDTRMRTRTKASIVAVMRAGQIYPSPGPDFVLVAGDLLVVVGTPQGLDEALEILTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWW3</accession>
    <name>A0A231GWW3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41110">
        <property type="protein sequence ID" value="OXR41110"/>
        <property type="gene ID" value="B7C42_06880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="37161" checksum="FFB245790C1DE997" modified="2017-10-25" version="1">MAGEQSSILLIADPGAPAAIAEHLSDSLSNERTDRSAPEGRDVSVRCHAYPIDEHTEFSEVVDTIDPGGQTEDVVIYLTDLPRRQGTTPVLADISVLDRFAVISIPGLGGAFIQRRVRDLARAVVAEMTSRSRPQEAAVERLNRVQDGDVVHYLAPSVLSRLRLLAGMVYANRPWRLVTGMSKVMMAAFATGAVSLAYGTMWRLSATMGPWRLSAATALASAALIAWLIIEHNLWERPHSRSERERAALYNASTVITLTIGVVVFHAALFILLMLTAWWTIPPQMVGENAGRPAGLATLLLMAWLVAAVATLGGALGSGMEDDKAVKAAAYGARQRRRFDHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX84</accession>
    <name>A0A231GX84_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41234">
        <property type="protein sequence ID" value="OXR41234"/>
        <property type="gene ID" value="B7C42_06632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="40" mass="4220" checksum="7BB574BAD32196D3" modified="2017-10-25" version="1">MSQVAPEDAAQVLCHVGNVYAGKGSGTCVIEWMFAPDAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXB5</accession>
    <name>A0A231GXB5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase YtpA</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytpA_4</name>
        <name evidence="2" type="ORF">B7C42_06658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41260">
        <property type="protein sequence ID" value="OXR41260"/>
        <property type="gene ID" value="B7C42_06658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="30875" checksum="BED1626BBA45517E" modified="2017-10-25" version="1">MSQQPTRVDFSSSGGLTVAAYRWDPQGAPRAIAQIVHGVGEHALRYTPLAEVLAARGFVVYAHDHRGHGATLLDSQEPGVIGADGWTELVADVGRMGRNARTANPGLKLVLIAHSLGSFATQQFLPEHSAEFDAVALSGTAALDLLPLDLDAPVDLSMFNAGIPSPRTEFDWISRDEAQVDAYLADPLCGFGLDIAGMKGMVGGAVAVAATECVASIRSDLPLYIAVGDKDPVNGDLALVNALVQRYEQAGLTDITLKVWHGARHEIFNEINRDEVFADLLAWIDRKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXG7</accession>
    <name>A0A231GXG7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2-halobenzoate 1,2-dioxygenase large subunit</fullName>
            <ecNumber evidence="9">1.14.12.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cbdA</name>
        <name evidence="9" type="ORF">B7C42_06653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.13" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41255">
        <property type="protein sequence ID" value="OXR41255"/>
        <property type="gene ID" value="B7C42_06653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018626">
        <property type="term" value="F:2-chlorobenzoate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="40"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="438" mass="49612" checksum="E9E06ECF05C046E7" modified="2017-10-25" version="1">MSEYVIDDREMPRFRVDRRVMVDPEVFAKERDRIFDRSWLYLGHESELSKKNDFTTRTVAGRPLIFARDNKGEIRVWINSCPHRGAMLCRERRGNARFLTCFYHGWSFSTAGNMVSMPGDDSYGEDFQRPDLAAPAKVDSYRGFVFVSFDPDIVDLRAYLGAAAEYLDLVCDQSEQGMRVLAGTHEYSVKANWKLLVENSIDGYHAVSTHQRYFEMVLAARGELDPNALGESRGVDLGNGHAVMAGRPTTEGLFGRPLSDAGAAERAARFDRLRELYGDGWVDRMRGNRNMVIFPNLVVIDLVMGVLVRKIDPISPDYMEVTAWELAPPEEGDELRKQRLDNFLTFWGPGGLASPDDVEALETCQVGYGARKELGFSDISRGMNKRVNSSTDELQMRAWWRRWNELITGEVLPPEEQDPLGEAFRAPRHTPQDAAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY52</accession>
    <name>A0A231GY52_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gap2</name>
        <name evidence="6" type="ORF">B7C42_06422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780932.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41530">
        <property type="protein sequence ID" value="OXR41530"/>
        <property type="gene ID" value="B7C42_06422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="5">
        <location>
            <begin position="127"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="496" mass="54164" checksum="28ABC3B8F0BF4376" modified="2017-10-25" version="1">MTTEQLDRWNAQEAAAEAMIPIIGTLYRAKGVTVLLHSRSLVNRSVISILRTHRFARQIEGEELSVDETLPFLRVLDELDLGPCKIDLGQLVVAYRADDRGLSVREFTEVVLAEVIGGNKAQSPGPRDVVLYGFGRIGRLVTRLLIEKVGSGNGLNLRAVVVRRGGEGDLAKRASLLRRDSVHGHFNGTIKVDADNDTIIANGNVIKFIYSDDPTTIDYTEYGISDAILIDNTGKWRDRDGLSQHLRPGIAKVVLTAPGKGDVPNIVHGVNHRDLDLTQRIFSCASCTTNAIVPPLKAMDDEFGITRGHVETVHSFTNDQNLLDNYHKADRRGRSAPFNLVLTETGAASAVAKAMPDFKAKITGNSIRVPTPDVSVAILNLQLERETTKSEVLDYLRQVSLAGPLSRNLDYTAATDVVSSDFIGSRAASIIDANATIVEGDTAILYCWYDNEFGYSSQVVRTVQYISGIEYPTYPQFADRSQDAADVRALAGVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYD8</accession>
    <name>A0A231GYD8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein LiaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">liaR_6</name>
        <name evidence="3" type="ORF">B7C42_06251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043724.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41610">
        <property type="protein sequence ID" value="OXR41610"/>
        <property type="gene ID" value="B7C42_06251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="244"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="33564" checksum="B46F959D331C3906" modified="2017-10-25" version="1">MSESAVRARLAAALELRDTAAGSPGGEPLKQQTARLLFALRRVVPYDHAALSIPDPVTGEHTTYSNFGYSTPTLDLINDAMPDMELYGELRETRLPVLLHDVDRRRRRGVVFDIIRRNGFRDGLSHCLYSPHGRYLGLLNLSTYTPLDEHTLPLTTLVSDALAAAVDPLRPANGGAIAIGAGEDALLIDLDGTPRPLTAGARTDLAAALIGLDPPAAVTVIHGAHVHEVRLDAVRGGTLIRHRPVPPPAGLTLRELEVLELLSHGAANTEIARTLRIGASTVATHVEAILRRTGSSNRTAAAVYATRIGLCRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ9</accession>
    <name>A0A231GYJ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41703">
        <property type="protein sequence ID" value="OXR41703"/>
        <property type="gene ID" value="B7C42_06045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="177" mass="18477" checksum="27ED2789882432EE" modified="2017-10-25" version="1">MEAGALRLLSPQLCQALASSVTAQVVFDELAVRSGTAFVQPEFTVAVCGEREDVSVDVVLASAGLLNADQRQPSGVRGGGDAGDDVVEAGSGPPAVGVLGQFTRMKAGVFEDDECVGIGELDGCGAEILTDEGEFADSAARRRESTSYGGSFEGRPHLGVHCRVGVRLRGGRRRRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYQ0</accession>
    <name>A0A231GYQ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">trpF</name>
        <name evidence="6" type="ORF">B7C42_06292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778302.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41651">
        <property type="protein sequence ID" value="OXR41651"/>
        <property type="gene ID" value="B7C42_06292"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="7"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="24525" checksum="B062CD25DA675219" modified="2017-10-25" version="1">MITVRTKICGIRSESDLRAVVAADADAAGFISGTTHFSEDELDPESAHRLSRLVPSSMERVLVTHLTDAGEVLRLADRIGVDCIQLHGLISPDTARAVRRGAGGRRVIRAVHVTGPEAIGAAEQAAPDCDGLVLDSRSTHRLGGTGRTHDWSISARIVELFDSPAFPVMLAGGLNPHNVPAAIDAVRPSWVDVNSGVDDGRGDKDPAHCAEFVRAARDVAAPIAALARPRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZC7</accession>
    <name>A0A231GZC7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative aliphatic sulfonates-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ssuA_7</name>
        <name evidence="4" type="ORF">B7C42_05953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41969">
        <property type="protein sequence ID" value="OXR41969"/>
        <property type="gene ID" value="B7C42_05953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144580" evidence="2">
        <location>
            <begin position="25"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="31"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="317" mass="32434" checksum="F8408A1C6532C6B5" modified="2017-10-25" version="1">MSRAVIAVLAFVALIVPLAACTGADDSDPHTLTVGFVVDPSWAQIPVAQQGEYFDRHGVKVKVVNFSTGVEALQALAAGQLDIATAADVPAAAALTRSPALRIVGDGSRWEGSRIVARRSAGIASLSDLGGRSVGTPLGTSAAYFASNALSHSNVGAKLVQVAPQAMVTAAGQRNVDAVAIFQPYQAQVIDALGGDAVELAGGTYSQHSLYLATDNAVSGKPDALTAFFAALGEAGTQLTSGAEPAIAAVAASTQLSADLIRKILPEFDFRLQLRPDLAATLTTLAGWAKSQGSLDKAAQLPDYQALAEPKFVPQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZD8</accession>
    <name>A0A231GZD8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bicarbonate transport system permease protein CmpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cmpB_3</name>
        <name evidence="6" type="ORF">B7C42_05963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41979">
        <property type="protein sequence ID" value="OXR41979"/>
        <property type="gene ID" value="B7C42_05963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="26950" checksum="5621B2B2563F8564" modified="2017-10-25" version="1">MTIVAARPRRRVAAWLPRLAAVGAAILLWWVLTDLVAGPQSLLREFGPQHVPGAIAGLLDRGVLLPDIAVSMWRLLVGLLIAVTLGVPLGLLLGLHAATEAAVAPVVQFLRMISPLSWAPIAVALFGIGHQPVIFLVAAASVWPIVLNTAAGVRSIDPGLLLVARSFGATRREQLTSVILPAIRGPVQTGFRVGLGIAWVVLVPAEMLGVRSGLGYQILNARDQLAYDQVMAVIVVIGLIGFALDSLARVVLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZK0</accession>
    <name>A0A231GZK0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative KHG/KDPG aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eda</name>
        <name evidence="2" type="ORF">B7C42_05915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779023.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41931">
        <property type="protein sequence ID" value="OXR41931"/>
        <property type="gene ID" value="B7C42_05915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="21711" checksum="CB5A5024175C446C" modified="2017-10-25" version="1">MTSPMDSVLQGSRILPVLTVPDPATAHLLAEALASGGARCAEVTFRTVGAEQVLETMAAHDALTVGAGTVLTREQVDRAVAAGARFVVSPGYAEEVVARCRELEVPVVPGVATATELMRALRAGCHTVKLFPAEPLGGLRTLRALAAPFPQAGFIPTGGIQDSHLASYLADPAVVAVGGSWMATATLLERGDYAEIRRLTAEAVDRSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZP5</accession>
    <name>A0A231GZP5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein OppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppF_1</name>
        <name evidence="6" type="ORF">B7C42_05965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41981">
        <property type="protein sequence ID" value="OXR41981"/>
        <property type="gene ID" value="B7C42_05965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="28437" checksum="6F84D3B783C40AFE" modified="2017-10-25" version="1">MTLLEATGLSRRFRLPRRSLWERPPLRHAVRDVGLSLAEGARLGIVGESGSGKSTLLRLLLALDRPDAGRIRYRDRPVTGRDLAWFRREVQVVLQDPLNSLDPRLLVGDSIAEPLRCLRVPGDHEERIAEVLAAVGLEPDAAQRYPHEFSGGQRQRIAIARALAPRPRVLVGDEPFSALDAAIRAQIIDLVRDLADEFGLSLILVSHDIGVVRQLCDELLVMKDGSVVESGSTATVLDNPRHPYTRTLLDAVPTLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZQ2</accession>
    <name>A0A231GZQ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41991">
        <property type="protein sequence ID" value="OXR41991"/>
        <property type="gene ID" value="B7C42_05975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="35404" checksum="214E936A9BDDD6AA" modified="2017-10-25" version="1">MVIMGHGLGAVRQMRLDAYAERFAAAGWSVLVFDYRHLGASDGYPRQLLDIGKQRADWHAALAFVRTLPEADVDRIALWGSSFGGGHVVQVASEDSRIAAVVAQCPFTDGPASLRSRLRTGPLSAIALTVAGVFDTVGSWFGAKPILLPMAGTSWMPAFVASPDALAGASALLPAGTRLSRRTSALLKRLPSVRARVSTNIELTEIDGGEEPATVVGRDSIWGVLRGAAGEFDAANALAARLALHLPLYRPGRALARFSTPTLLCVCDNDAAAPAKTTKRHARGLAHVHVQNYPCDHFDIYVGEHFERAVRDQLYFLATQFDYTARTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZS9</accession>
    <name>A0A231GZS9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782303.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42052">
        <property type="protein sequence ID" value="OXR42052"/>
        <property type="gene ID" value="B7C42_06036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="93" mass="9858" checksum="9CF1B3238196FEA6" modified="2017-10-25" version="1">MILLAMHDVIVAQVGNPTPETPPAADKLLKLVRYFTWFMLLSGTSAIIFAGGRFAWEKWNGGPLQSPKMVAGALVGGLVATSAGTLMNSILTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZV4</accession>
    <name>A0A231GZV4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783707.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42144">
        <property type="protein sequence ID" value="OXR42144"/>
        <property type="gene ID" value="B7C42_05743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="17882" checksum="C4FFF5D0E76B3A5E" modified="2017-10-25" version="1">MSESPRPLDAAQLGAYFALMEVAGLLRHAVEQQLRDAGDLSYVQFQLLARLGLDSPTGSERMTDLADGVVYSRSGLTYQAGLLEKAGLVTRAPSADDERSVTVTITDAGRSLLAEVLPGHTEVVNQQLFEPLSREDTTTLAALLSPVRDHMRAAPPRSAAPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H079</accession>
    <name>A0A231H079_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42265">
        <property type="protein sequence ID" value="OXR42265"/>
        <property type="gene ID" value="B7C42_05464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16719" checksum="BDC3F0A056EBB410" modified="2017-10-25" version="1">MSLRPDRCWEAEAETNVFLGRAGKNDFLTPDFLVHRCLPPYADVRAADTVLVGEVRSPSNSQTDMEAKKARYASAGIPWYWEVTLQRDVSSIDVVRAYGLEVGHARLPDGVTPLRPANYLLVGEWTHNDEAGIAFGHPFDITMPWSALAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0A7</accession>
    <name>A0A231H0A7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FA_desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779735.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42252">
        <property type="protein sequence ID" value="OXR42252"/>
        <property type="gene ID" value="B7C42_05851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="41224" checksum="B8262DE22D9356B7" modified="2017-10-25" version="1">MKLATRLPGERHLERADADRIAQIRGAIIAIGDSWRARHPWITAHQDRIGLGIFLAAIAGVVADGWLYHAGVLPWWVTIPLTGFWLSLLHELEHDLIHSMYFRNNRFVHNLMMFGVWFFRPSTINPWVRRRLHLHHHEVSGTDSDLEERAITNGEGWGAHRLVSLLDSVLGMYAKPFRMRRIVENYIEHEARTPQEARQLATVNALSYFPLGAVHYTLWHLFLGIHAYQLVMGPISIPGQGILDFLAVAILAPNAVRTFCLHFVSSNMHYFGDVQAHNVLQQTQVWTAKWLKPFHALCFNFGETHAIHHFLVRDPFYIREAIKHDCQAVLRDNDVRFNDFGTFRRANRFALTSASVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B6</accession>
    <name>A0A231H0B6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor KstR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kstR2_10</name>
        <name evidence="6" type="ORF">B7C42_05790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42191">
        <property type="protein sequence ID" value="OXR42191"/>
        <property type="gene ID" value="B7C42_05790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23714" checksum="100F586235435288" modified="2017-10-25" version="1">MESTQPRAPIAPPAGNRRGRRSRAEILDAASRLMAERGYAATTISVLSAETGLPKSAIYHHFHSKGGLLSAVMAHGAYDFYRAMAQAQATPPEGGTARERLGWFLERTEEVFMTKADFLRLHLILLMSTEAADAEVGSMIEQVRTDGRRHMNRMIAQSFIAEGDEIAQAVADELDYFGIAGFDGAFIAWQADPAHGLTGQLARLADALAALGAGIVASRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1A7</accession>
    <name>A0A231H1A7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-glyceraldehyde 3-phosphate reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gpr_4</name>
        <name evidence="2" type="ORF">B7C42_05413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778207.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42635">
        <property type="protein sequence ID" value="OXR42635"/>
        <property type="gene ID" value="B7C42_05413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="33006" checksum="02C422FF7D5A15FD" modified="2017-10-25" version="1">MEQRAVGRSGLRVSRMGLATHTWGRETDAEDAAAQLVAFVEAGGTLVDTSPVYQGGAAQRMLGELVGELVPRDDLVISGCAGLVPVPGVTDPDGGPAAGIHWSVDASRRTLMRQLDRTLAELGTDYLDIWSVAAWDRHTPLDEIAATLDHAVRSGKVRYAGARGLSAWQLATLASTAPIVAAQSPYSLLARGAESELLPAAGHHGVGLIAASPLAGGILTGKYRDGVPADSRGADEATAAEIRERLDEHATRVVDAVVTAADGLGTSPLAVAAAWLRDRPGVASMIVGARDIGQLTGVLAAETLELPRAIAAALDDVSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1C9</accession>
    <name>A0A231H1C9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Soluble epoxide hydrolase</fullName>
            <ecNumber evidence="2">3.3.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42665">
        <property type="protein sequence ID" value="OXR42665"/>
        <property type="gene ID" value="B7C42_05443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="32595" checksum="7D37AA6EA27D337E" modified="2017-10-25" version="1">MASTFTPAPDRTEFDLGQVTLHALTWGDPAATLALCLHGYPDTAWTWRRLGPALADHGYYAVAPFSRGYAPSTVPADGDVSTGSRVADALGIAEHLGAERAVVIGHDWGAFTANALAALPESPFRAFVAAAVPPLASVRITRDDLAGHVARTLAQSVNSWYILANQLPALPERFFTPMTALLWRRWSPGYDATDDLAHLAAAAPAQHRSAIIGYYRQLVRPRSTRPRDLDRLLMSPPIHPTLQLYGATDGCLRPGFFQDLDRHLPAGSRVVRIDDAGHFLHLEKPEAVNAIILDYLAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1L3</accession>
    <name>A0A231H1L3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bile acid 7-alpha dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.106</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">baiE_2</name>
        <name evidence="2" type="ORF">B7C42_05077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.106" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776897.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42740">
        <property type="protein sequence ID" value="OXR42740"/>
        <property type="gene ID" value="B7C42_05077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033988">
        <property type="term" value="F:bile-acid 7alpha-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="160" mass="17774" checksum="B4C68AA6762B7452" modified="2017-10-25" version="1">MDLVALEEIRALKYRYLRTLDLREWDEFADTLAADAVADYGSPSGGKPLQFQGRDAIVGYLSGAMSGTMITSHVCSHPEIAVDGDSASGSWCLEDTVIVPEHGIMIRGAAYYRDTYRRESDGRWRITSTGYQRNYEAMIPLSSIQGFTITASRWDPSVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1W4</accession>
    <name>A0A231H1W4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42831">
        <property type="protein sequence ID" value="OXR42831"/>
        <property type="gene ID" value="B7C42_05169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="276"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="276"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="43270" checksum="E317563B7AC59E63" modified="2017-10-25" version="1">MSEARPTELKPLDGFTIGVTAARRADELATLLSRRGANIVSAPAIRIIPLADDTELERVTRQLVADPPQIAVATTGIGFRGWMEAAEGWGLAENLRDTLASTRMLARGPKAKGAIRAAELREEWSPASESSAEVLDHLLAAGVEGVRIAVQLHGATTEWEPVPDFCEVLRCAGADVVPVPVYRWVPPDDRVPMDRLIEGVVTSALDCVTFTSAPAVASMLMRAKETGLLEGVLQAMRSRVLPACVGPITAAPLEELGVPTSMPGRARLGALARHVAEELPRRANRIHAAGHELSVRGGCVVVDGSVRQLAPAPMALMRALARQPGRVVSREDLLAALPGGGDDTHAVETGIARLRAGLGTPKAIQTVVKRGYRLALDPAECVDNNTRPPGGYAPSLRPQRPAPMAGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H222</accession>
    <name>A0A231H222_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42889">
        <property type="protein sequence ID" value="OXR42889"/>
        <property type="gene ID" value="B7C42_05228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="228"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="442" mass="50171" checksum="65DEA4376ABE402C" modified="2017-10-25" version="1">MKQGHVRKRGKTWYYQFRLPEKKPNGKPDYDSKGGFATEKEAWAACRDAMKAVEQNKHVKRSKVTVRTYLLDQWLPAIKMTVDATTYDNWKELITAYVVPRLGDGDLQKLTAPMLVAFYTDLLANGRIKPDNNIRMYEYWAKTTSNRQRPTPREITTACGVTIHAARAAVRRYKSGRIPTPKPPGLQPKTVRNIHIALHRALVDAVNIWKYLVDNPADHAKPPRVAQTKRPVWTPEQATRFINSVRFDRFYALFRLELTTGLRRAEICGAHWPSLDLHTGALSVHKGRVVVAGHTQDADVKTEDSARWIALDTETVQALRAWKAIQDAERALYGDDYRDTDFVFTYEDGRPAHPDSIRERFKRLAARAGLPEIRFYDLRHTYITGALMAGINPKVVSQRVGHTDVAFTMKTYQHVLPGMDEDAAAIAATHLLGGTPRTPQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2E5</accession>
    <name>A0A231H2E5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43014">
        <property type="protein sequence ID" value="OXR43014"/>
        <property type="gene ID" value="B7C42_04900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="345" mass="37304" checksum="72555A2CBAD1DF72" modified="2017-10-25" version="1">MRIGLGINYAGGFKEVAAEVADLEQAGLDIVFVPEAYSYDAVSGLGYLAAKTERVQLASGILQLYTRTPTLTAMTAAGLDYVSDGRYVLGLGASGPQVIEGFHGVPYDAPIGRTREVVEICRKVWRRERLEYQGKYYTIPLPAERGTGLGKPLKLINHPVRDRIPVLLAALGPKNVQLAAELAEGWQPIFFLPEKARDVWGEALAAGTAKRDPELGALDIYAGPALAIGDNVEPLREFVKPHLALYIGGMGAKSKNFYHSLATQYGYGAEADRIQELYLAGKKDEAAKVVPDELVRDISLIGSAGFVKERVAAFREAGVTVLNVVPLAATAGERVKLIEQLRELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2W5</accession>
    <name>A0A231H2W5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate dehydrogenase complex repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pdhR_1</name>
        <name evidence="6" type="ORF">B7C42_04611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43189">
        <property type="protein sequence ID" value="OXR43189"/>
        <property type="gene ID" value="B7C42_04611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="29262" checksum="DDF157FA2B2712AE" modified="2017-10-25" version="1">MAVDSPTGASRGAQRSPARGTTQRVRVPKMAELVAAELRRRIIRGELSEGEALSSETELMSRFGVSRPTLREAYRVLESERLIVIRRGANGGARVQPPRREVAARYAGFILEYQGASVKDVYEARAALEVPSVGRLALRRSAADLAALTEALDRYDDEYDPSRSIRLHGEFHQLVVRLAGNETLTLLSEMVHHIIETANVTLQPDSGPSAERARRDTGRVHRKLVELIRGRDARAAEELWHRHLGEAEGYVLGDDAATSVLDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H336</accession>
    <name>A0A231H336_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin reductase</fullName>
            <ecNumber evidence="3">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcD_4</name>
        <name evidence="3" type="ORF">B7C42_04702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43280">
        <property type="protein sequence ID" value="OXR43280"/>
        <property type="gene ID" value="B7C42_04702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="326"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="42627" checksum="2EB4CD4A07462228" modified="2017-10-25" version="1">MTPHNPRSVVIVGASAAGLSVAEGLRRAGYTARVTLIGEEPHLPYDRPPLSKQLLAGDWDSTRVLLRSQGDIDGLDLDLRLDRRAVALDTNDRHVLLSDGEQVGYDALVVATGVAARRLPGTDNLAGVHVLRTLEDALAFRDTLRALPNLVIVGSGFVGAEAAAVARTLGTEVTMITDVAAPLSDALGAELGDMLTQVHRDHGVHIETGALVDAVTAESGRATGVRLADGRTIEADAVLVGIGATPNTDWLAGSAVPVGNGVHCDATLHAGSGVWAAGDVACWQHPRTGIPTRIEHRTNAAEQGMLVARNILAGPEAAQPFDPIPYIWSDQYDLKFQIYGRTRGAQRVDVVEGSIAERRLVALYSDGGRVCGAVGINMPRATRGYRAHVAANSPVEPLLPVGISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H359</accession>
    <name>A0A231H359_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43295">
        <property type="protein sequence ID" value="OXR43295"/>
        <property type="gene ID" value="B7C42_04717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="5850" checksum="CF8D09AB12ACA075" modified="2017-10-25" version="1">MTIPAVAANCVVGAVAVGGLGAGLGGAAVAIPVGIAAGTQKFNQLQAQRAQGAATPPGHRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H362</accession>
    <name>A0A231H362_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43236">
        <property type="protein sequence ID" value="OXR43236"/>
        <property type="gene ID" value="B7C42_04658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="160" mass="16987" checksum="C33C563D45BEDB5E" modified="2017-10-25" version="1">MTTALGLDWLLDPSLAPDAGDALLEPFYTAASYDQLALPFCADCGIPKDLDQHICDDCGSARTSWRTVESSGTVHSVTVMHRLEPGLVRTDAPYPILDVELASGHRLIMTTRDRTDVAFGIGDPVAIGFRRLGGVAVPAAVPLPAPAHESTAHPISEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3S5</accession>
    <name>A0A231H3S5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502798.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43510">
        <property type="protein sequence ID" value="OXR43510"/>
        <property type="gene ID" value="B7C42_04377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="22076" checksum="BC3D92ECF5E2479D" modified="2017-10-25" version="1">MAEELDDIGRETAALMRQMLQLATLVALRTRERGQREAEARVKVTQERVKETRERLLREAREAKAKDPRNLELARMLERPALERGISLEKGLEHSRVARGARAAADRQKARERELTRYDSPERRQALAAHLSRVGVAPELAAVRMLMDVSQAQPPQAAVRTRPEEPPRVTRAREHDERMRERERNRERNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Y8</accession>
    <name>A0A231H3Y8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">thrS</name>
        <name evidence="14" type="ORF">B7C42_04323</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43456">
        <property type="protein sequence ID" value="OXR43456"/>
        <property type="gene ID" value="B7C42_04323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012985931" description="Threonine--tRNA ligase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="12">
        <location>
            <begin position="292"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR43456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="685" mass="76679" checksum="03AD3F8CDF0FE4E1" modified="2017-10-25" version="1">MTTSARITPAALVRVPAGTTAGAAVREAGLATKGPDTVVVVRDDEGNLRDLSWAPETDVEVEAVTAGSEDGRSVIRHSAAHVLAQAVQQEFPEAKLGIGPPIKDGFYYDFQVERPFTPEDLAKLESRMKKIIKGAQRFSRRVVEVDEARVELAKEPFKLELISDKSGIDDPEVMEVGGKELTIYDNLDPRSGEKVWGDLCRGPHIPTTKFIPAFKLTRSSAAYWRGDQNREDLQRIYGTAWESPEALENHLHVLEEAEKRDHRKLGLELDLFSFPDELGSGLPVFHPKGGIIRKELEDYSRRRHIAAGYEFVNTPHITKGHLFEVSGHLDWYREGMFPAMHLDAEYNDDGTVRKPGQDYYVKPMNCPMHNLIFRSRGRSYRELPLRLFEFGSVYRYEKSGVVHGLTRVRGMTQDDAHIYCTKEQMHAELTSTLQFVLSLLRDYGLDDFYLELSTKDPQKFVGSDELWEEATETLRKVATDSGLDLVPDPGGAAFYGPKISVQAKDALGRTWQMSTIQLDFNLPERFGLEYTASDGTKQRPVMIHRALFGSIERFFGVLTEHYAGAFPAWLAPVQVVGIPVADAFAEHLDTVVEELRAHGVRAEVDRSDDRMQKKIFNHTAQKVPFMLLAGERDVNAGAVSFRFRDGTQVNTVPVADAVATVVDWISRRDNASPSAEGFEVRTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4A9</accession>
    <name>A0A231H4A9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780381.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43704">
        <property type="protein sequence ID" value="OXR43704"/>
        <property type="gene ID" value="B7C42_03939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22144" checksum="C3241715475F573C" modified="2017-10-25" version="1">MNSAANEPAVGRQPTARPGGRTARIREHVLAAVQAELTEHGYDALTVDSVAARAGVHRTTVYRRWRDVGGLIADVFAAASDLDWQPPDTGSLTGDLTELDREIQDSLTEESSIASALIAVSFRSEDAARALRQLWEDRYAQCEIVVERAIHRGEIPAETDTRAVLVAATAPLYHQLVLLRTPADPEGPRRAATAAVLAAQAGAFAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4B4</accession>
    <name>A0A231H4B4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
            <ecNumber evidence="2">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43677">
        <property type="protein sequence ID" value="OXR43677"/>
        <property type="gene ID" value="B7C42_04545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="14894" checksum="BBB449ACDF7ADB24" modified="2017-10-25" version="1">MPTPALPLSGLETLLTATPKGIGRLLGMQFDTVEEGTVTFSLTTRPEFVNVSGQVHGGIYATLLDSVMGCAVHSTLEPGIGYTTLEMKINLTRAVSAERAKLVATGRTLHVGGRTATAEGEIRDEMGRLVAHGTTTCLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4T0</accession>
    <name>A0A231H4T0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="4">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acsA_4</name>
        <name evidence="4" type="ORF">B7C42_04192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43953">
        <property type="protein sequence ID" value="OXR43953"/>
        <property type="gene ID" value="B7C42_04192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="91"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="530"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="648" mass="69639" checksum="A4E991EE51186A8B" modified="2017-10-25" version="1">MTQPQWEPDAGDVETARVTDFARFAETRTGREFDDYHSLWEWSITDLAGFWGALWEYFELGDAPATVLASSDMPGAQWFPGQLLNYVDQVARHARTDRPAIVYAGEQGGLTEISWAQLLGRAASFAATLRELGVGPGDRVVGYLPNIPEAVIAFLGAAAIGAVWSACGQDYSAKAALDRLGQLEPAVLVTADGYHFGGKQHDKRDDIVALRAGLPTVRATVVVSRLGGAVPDALDWNAVAAPEGAELSTEPVGFAHPLWVLFSSGTTGLPKGIVHGHGGVLLEHLKAAALQSDIGRGDVFFWYTSPSWMMWNFQVAGLLVGATIVCYDGSPTFPHADSLFDLAARTGTTVLGTSPGYVLACIKAGVVPRRDHDLSALRTVGITGSSLPPSSALWLRDNVGERVQVNSISGGTDVVSAFLGGVRTVPVWPGELSVPFLGAAVDAWDESGRPVRGEVGELVITAPMPSMPVSFWNDPDGSRYRAAYFEMFPGVWRHGDWITVTDHGSIVVHGRSDSTLNRHGIRMGSADIYQAVEQLPEVAEALVIGAEQPDGGYWMPLFVTLAPGAELTDELKQRINATIRSEVSPRHVPDDIIAAPGIPHTRTGKKLEVPIKKLFQGADPDRVVERSAVDNADLLTWYAEVPARKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4W6</accession>
    <name>A0A231H4W6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780970.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43939">
        <property type="protein sequence ID" value="OXR43939"/>
        <property type="gene ID" value="B7C42_04178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="23488" checksum="50A28A77F198ABAF" modified="2017-10-25" version="1">MPLLSDPAALAGLVTREVRTGSRDGATTRIAVARRSYPTDQADLWDALTNPERIPRWFLPISGSLEVGGRYQLEGNANGVVERCDAPKHFAVTWEMGPQISWLEVTLGPAGDGTELKLEHEAPIDPAMWTQFGPGAVGVGWDLALLGLGMHLDSGEPVDPTVALTLHTTPEGRTFIRTAATAWGEAAIADGDDPTAARTAAEQTFAFYTTEPEDTPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5U7</accession>
    <name>A0A231H5U7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cation-transporting P-type ATPase J</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctpJ</name>
        <name evidence="8" type="ORF">B7C42_03172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44383">
        <property type="protein sequence ID" value="OXR44383"/>
        <property type="gene ID" value="B7C42_03172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="652" mass="67722" checksum="EE9D8B688092D38F" modified="2017-10-25" version="1">MSAPVATRPAALTAIPTRRTRLFALPEIRWATAALLLFTAGSVARLLHTPPEVWWSLYLACYLTGGWEPALAGVRALRERTLDVDLLMVVAAIGAAAIGQITDGALLIVIFATSGALEAFATARTEDSVRGLLDLAPDTATRIDDGVETTVRAADLEVGEVILVRPGDRIAADGTVVAGASEVDQATITGEPMPVDKTPGDEVFAGTSNGTGVLRVRVGRRAEDSVVARIAALVEQAGRTKARAQLFIEKIEQRYSVGMVAVTLAVFAVPLIFGAALRDSLLRAMTFMIVASPCAVVLSTMPPLLAAIANAGRHGVLVKSAVVMERLGSTTRVAFDKTGTLTRGVPELTDIRVLPDCPYTGEEVLRWAAGAEYSSEHPLATAVVRACHERGLALPPVDHFSAQPGRGVTATVVRHLIEVGSPAALLDSPDTDAAAIVAEIQAAGHTAVIVRHEHRPIAILGLSDQARPEAAESVAALTEITGAAPVLLTGDNLAAARQLAGRLGLTDVRAELLPEGKVAAIEELEATGDRVTAVGDGINDAPALAAAHAGIAMGGNGSDLTLHTAGAVVIRDDLTTVPAVIALSRRARRTVMANLIIAATFIAALITWDLAGHLPLPLGVAGHEGSTVIVGLNGLRLLRRSAWDSGTARGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5X1</accession>
    <name>A0A231H5X1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44162">
        <property type="protein sequence ID" value="OXR44162"/>
        <property type="gene ID" value="B7C42_03721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="39232" checksum="A8DA25D6EEDFAC4B" modified="2017-10-25" version="1">MLRHGEPVVDVWTGYSDLTTPWTRETGSVAFSATKGIASTVIHRLADRGLIDYSAPVAEYWPEFGAAGKSRITVAQLLTHRAGLSSLPPVAGGLDEVLDHELMEHRLAAAAPDRLLGVPAYHALTYGWLLAGLARAVTGTSMRELFRTEVSEPLGIDGLHLGRPAPDSGTTVAALAGSRLAVAGTALGALVLGQAGRFPGPAGAATRALFLPGLHALFDGDEPSILATEMPAGNGVFTANALASVYGVLADGGMIAGRRYLSAQTMRQIRRVQTHRLDHALFYFPMMWHLGYHTFPIPGASSGFGHIGLAGSFGWAEPRLGLSVGFVHNRFTPQSFVWDQLAAAWVLPLVMRGARAMRDGRRTSARRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H653</accession>
    <name>A0A231H653_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44310">
        <property type="protein sequence ID" value="OXR44310"/>
        <property type="gene ID" value="B7C42_03871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="34181" checksum="A672950499AC97B8" modified="2017-10-25" version="1">MRSDDDSWDITESVGATALGVAAMRAAETRRPDALFRDPYAARLVEAAGSGWSHIMRAQVAATSAGADPAGEGEPAYSSLAAMLIARTVYFDEYFAAASAAGIRQVVILASGLDARAYRLEWPSGTVVFEIDQPKVLEFKNSVLADEQPAVDRRAIAVDLRQDWPKELWDNGFDPTAPTAWLAEGLLRYLPGEAQDRLFDDIAALSAPGSRIALNIGRGRREDSPARRAMRERRKRLLAEAGITLNLEELWYPWEGRTDPRDWFAAHGWTVTTGDPVSLLTDHGREQPDVARAELNHHILMTATRGDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H689</accession>
    <name>A0A231H689_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular esterase EstB</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">estB_3</name>
        <name evidence="2" type="ORF">B7C42_03213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44424">
        <property type="protein sequence ID" value="OXR44424"/>
        <property type="gene ID" value="B7C42_03213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013121990" evidence="1">
        <location>
            <begin position="33"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="33518" checksum="A7D337B1FCBDC1DD" modified="2017-10-25" version="1">MPSHFAHLPRRALGAALVLAISSILWVTAAAAAHAEYPVDYNFFSGIPYELRNPGGSLPGADDWSCRPSDAHPEPVVLVHGTGGGAQTNWGVYAPLLANAGYCVYSLTYGAYDLPWPLSAIGGMRPIEDSSAELAAFVDRVLAATGAEKVDLIAHSQGNLVGNYFVKRLGGADKVDKFVAIAAPWLGTFGPVIDPAREIARRLGAGSAFDAALGASPCAACAQMTGSTDFIRSLNADGVYDPDVTYTNIETRYDELVVPYTVALVPGPTTTNIVVQDGCAADYSEHAGIAGSDRAAAFALNALDPDDPQAVPCHFIPPITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D9</accession>
    <name>A0A231H6D9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispD</name>
        <name evidence="1" type="ORF">B7C42_03230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44441">
        <property type="protein sequence ID" value="OXR44441"/>
        <property type="gene ID" value="B7C42_03230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="20660" checksum="62C8B9FE8E524EFF" modified="2017-10-25" version="1">MLVHAVDGLIASGVVDRIVIMAPIEMIDAARELLAARAHAASSIPVDVVAGGVERTDSVRAGLAAAPEATHVLVHDAARALTPPSLIARVVDALDAGHRAVVPGIPVTDTIKAVDAAGDVTGTPDRSGLRAIQTPQGFDAALLRDAYALDLPATDDAGLVEATGATVSVVPGDPLAFKITGPLDLKLANALAADATLPATTGAAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6H1</accession>
    <name>A0A231H6H1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44623">
        <property type="protein sequence ID" value="OXR44623"/>
        <property type="gene ID" value="B7C42_03417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021941">
        <property type="entry name" value="DUF3556_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12077">
        <property type="entry name" value="DUF3556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="600" mass="66156" checksum="5FA19CC86BA855F8" modified="2017-10-25" version="1">MGFTKPDLPAVDPDTFLQKPLMERMRILGADWAENGFGSPKMVHCVYILKLVVFYAIGGITVATLTSGLPAFWHVAEWWNQPIVYQKAVVWTVLLEVVGLAGSWGPLAGKVKPMTGGILFWARPGTIRQRPWAWVPGTGGDRRTWFDVTLYLALLASLVLALALPGAHSDSLAAAVPDNVSGLIAPAVLLAPIVLLILNGLRDKVVFLGARGEQYLPALIAFTVFPFVDMIVALKLLIVVVWVCAGFSKLGKHFSNVVPPMVSNSPSVPFKSVKRAHYKDFPRDMRPSGIAHFMAHVNGTCVEMLVPLVLLFSTNKWVTSIAVLIMVIFHLFIVSTFPLAVPLEWNVLFAYATVFLFLGFPAWNGYAVWDMSPVWLAVPVVAALLFFPVLGNLRPDKVSFLPSMRQYAGNWASAVWTFAPGAEEKLNRVTRSAGNQIDQFIDFGYEPQWAEITLQKTIAWRTLHSQGRGLFSLLIARLPDIDSRTVREGEFLCNSIVGFNFGDGHFHDEGMIRAVQDEARFEPGECVVAWVESEAFGSGVQHYKLIDAALGVIERGTWRVADAVAEQPWLPNGPIPLRPTWTRAAAARIEPTQDDFGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7F1</accession>
    <name>A0A231H7F1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamine synthetase</fullName>
            <ecNumber evidence="7">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glnA_1</name>
        <name evidence="9" type="ORF">B7C42_02719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500008.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44765">
        <property type="protein sequence ID" value="OXR44765"/>
        <property type="gene ID" value="B7C42_02719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="8">
        <location>
            <begin position="105"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="478" mass="53621" checksum="FD208E264006C0C8" modified="2017-10-25" version="1">MAFSTADEVIKYIKEEDVEYVDVRFSDLPGVQQHFSIPAKSFTSDLAEEGLAFDGSSVRGFQSIDESDMLLLPDFSTARIDPFRAAKTLNLNFFVHDPFTREAYSRDPRNIARKAEEYLRSTGIADTAFFGAEAEFYIFDGVRYGSGMNGSFYEIESVSGSWNTGKEFNPDGSRNLGYKVRNKGGYFPVAPYDHYVDLRDKISTNLQNAGFELERGHHEVGTAGQAEINYKFGTLLSAADDLQLFKYIVKNTAWQEGKSVTFMPKPLFGDNGSGMHVHQSLWKDGKPLFHDEAGYGGLSDLARHYIGGILHHAPSLLAFTNPTVNSYHRLVPGYEAPINLVYSQRNRSAAVRIPVTGNNPKAKRIEFRAPDSSGNPYLAFAAMMMAGLDGIKKKIEPKAPVDKDLYELPPEEAKNIPQAPTSLASVIDRLEQDHEYLTEGNVFTDDLIETWIQLKRDNEIAPVNLRPHPYEFELYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7F8</accession>
    <name>A0A231H7F8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase A</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">caeA_1</name>
        <name evidence="3" type="ORF">B7C42_02732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44778">
        <property type="protein sequence ID" value="OXR44778"/>
        <property type="gene ID" value="B7C42_02732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011274056" evidence="1">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="103"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="513" mass="54588" checksum="FD5CE2EE7C90CD5D" modified="2017-10-25" version="1">MSLSRSGRVAAAVALMCVAAACSSTSKNHPVPQPSAPSPAALQKYYTQVPSWGSCDGFGDSSTRFPQGTECTHISVPIDYDKPEGATAQIAVSRIKATGQRIGSLLFNPGGPGQAGLWMAAQGQDTPLAQRFDRIGFDPRGVGASTPLIECLTGQQWDQQRAEPPKDYTPAGIAAAEQENKDFAAHCTEKTGNEFLAHVGTREVVQDMDIIRGVLGDDKLNYVGYSYGTRLGYTYAEKFPDKVRAMVLDGALDPDADPEKESVQQAAGFQKAFDAYAADCTSKPDCPLGQDATQAVARFHDLVNPLWNHPAETRDGRGLTYSDAVTGVQNTLYAEDSWNVLSAGLAQLAKGKGDILLQLADLYDGRSKDGTYDNSQDAFLAIHCVDDPAIKDRTETDKQDAEYRKVAPFLDDGHATGQAPLEMCAFWPVPNSGSPHNISAPGLPKTVVISTTADPATPYQAGVDLAHQLGAALITNKGTRHTAFLSGGVPCVDDAVFAYLTDLKTPPEGLTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7J3</accession>
    <name>A0A231H7J3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B7C42_03490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44696">
        <property type="protein sequence ID" value="OXR44696"/>
        <property type="gene ID" value="B7C42_03490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04863">
        <property type="entry name" value="MtLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033649">
        <property type="entry name" value="MtLigD_Pol-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="585"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="286"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="447"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR44696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="785" mass="86592" checksum="29F23395FF73C19E" modified="2017-10-25" version="1">MAARREFGGIEVGLTNLDKVLYPATGTTKGEVIDYYTAIAPALLPHIADRPVTRKRWPNGVGESSFFEKNLAAHAPKWIERRPMEHSDRRVNYPVIDSVAGLAWLGQQASLEIHVPQWRFVDGSRGPATRIVFDLDPGPGVELADCASVALWIRDTVRDAGLDAYPVTSGSKGIHIYVPLDRVLSPGGASTVAKQLATGLEKLHPALVTATMAKAVRPGKIFLDWSQNNPAKTTIAPYSMRGREQPTVAAPRSWDEIADRHHLRQLRFDEVLERWRSDGDLLAGLDPPLGSAGASDPLQTYRSMRDPARTPEPVPPGPPDPGAGDRFVVQEHHARRLHWDVRLERDGVLVSWAVPKGPPTSPSQNRLAVHTEDHPLEYLHFHGTIPRGEYGAGQMTIWDTGTYDTEKWRADEVIVQFHGERLNGRYAFIRTDGKQWLMHLMKSQAAVPEDDAGQGGSSDGQGGAAPDGDTERRRGGSGTGGAGGDSVARAGAEFPRGLSPMLATSGEVAKLGARDWVFETKWDGFRVIVEIDDDGVVIRSRAGNTVTGRYPRIAELGRQLRGHRIVLDGEAVVFDAEGASNLALLQADPARADLVAFDVLYLDGTSLLRKRYADRRQVLEALAEGVPSLLVPPRLDGSGADALEYSREHRLEGVVAKRKDSVYLPGKRGQSWIKTRNWRTQEVIIGGWRRSAAREFASLLVGVRHEGELYYIGRVGTGFSDREMSELTARLRPLRRKTSPFANELTADERKDAVWATPKITGTVRYMNWTESGRLWHPAWVPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7K7</accession>
    <name>A0A231H7K7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500003.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44770">
        <property type="protein sequence ID" value="OXR44770"/>
        <property type="gene ID" value="B7C42_02724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021607">
        <property type="entry name" value="DUF3224"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11528">
        <property type="entry name" value="DUF3224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SSF159238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="14087" checksum="5898C99D9179FF86" modified="2017-10-25" version="1">MRATATFTVKSFVATDVLPDPDIPTATPVGIARLEKHFEGEAVGRSATLFTAAFDQLSGRGTYVAMESFEGSLNGLAGTFNFAHSATTAGADRSAEFFTIVPSSGTGELSEITGTGGLAVDADGTHRIWFDYDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7R6</accession>
    <name>A0A231H7R6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pdhC</name>
        <name evidence="8" type="ORF">B7C42_02843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44888">
        <property type="protein sequence ID" value="OXR44888"/>
        <property type="gene ID" value="B7C42_02843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="43182" checksum="C53C1AB9C830FED9" modified="2017-10-25" version="1">MPRLSDTMEDGVVASWLKQVGDTVTRGEVLAEIETDKALMELEAYDDGILERIIAAPGTRVPIGEPIAILGDGSGTAAAPTLSSTVQQAETASAQPHTEQPQEPAPQSAADAVRRKSSPLARKIAQELGVDITTVTGTGPGGRITRLDVENAHATRTPDTAQTTAAPEHTEPATPATGDYDEIPLTGIQRVSATRLTESKQQAPHIYLTSAIDVTELLAFRTRINETLADTGAGKVSVNDLLVKAVATTLRANSAVNVSFAGDTLRRHHGIHLGVAVATPAGLLVPVIRDADRKTVSAIAAETRDKAERARDRKLRAEEMTGGTFTLSNLGMYGIEHFTAVINPPEAAILAIGAATDELRLDGDEVVRRKVLRVTMSADHRAIDGAVAAQFLAQLRELVEHPLRIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7S0</accession>
    <name>A0A231H7S0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="4">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45063">
        <property type="protein sequence ID" value="OXR45063"/>
        <property type="gene ID" value="B7C42_03020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759754" evidence="2">
        <location>
            <begin position="42"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="142"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="487" mass="48449" checksum="5AA615F668399F64" modified="2017-10-25" version="1">MCPSRVRRPNMNHPRIIKTGVRLAVAAVTTAGVLAPAAALAAPAAPADPDMSTRLAGKTVFLDPGHQGTNHSEDLNRQVNDGRGGTKECQTTGMTSRGGVPEHTINWNVAQLVRQSLEALGAHVVMSRQDDTGWGGCVDERAAAANSSGAAVAVSIHADGAPEQDHGFHLIVPQLPVPDAKANQAQSGPGQVATNAVRDAYKQAGFTPANYAGAVDGLQTRSDIAGPALTEVPDVFIEMGNGANVDDAKMLESPDGQLKHAIAITTGLVSYLIGVAPGGTSPAASPADSPAGAPQAGASESTTAPTTTPQSPAPQTAAPESASPQGSTTQNPDAQNSGTQNSGAQNSGAQNSVAPQQNSATDALRGAPNSGTTQSAPASTSPSASATTQPGSNPAGAPAGTYHTAPGTYSTTDPGTSGASPQTSTAPGTSGTQKTPQSGSAAGNLATTAMRLLLPLAKSLGLGDGALDSELVNLAYTLVSTLLGPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7U4</accession>
    <name>A0A231H7U4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_062963164.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44918">
        <property type="protein sequence ID" value="OXR44918"/>
        <property type="gene ID" value="B7C42_02874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12594" checksum="B8D0F55CC4980B81" modified="2017-10-25" version="1">MATRGVEAIFLETHNWGKSAKFFQQLGFELEFATDHNSGQLRNGDGPYLFIAEVPADREPGMQVVLKVEAEQDFPAPVEVVSPFADTHYGTREMTVRDPDGRVWTLQAPGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8B5</accession>
    <name>A0A231H8B5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45184">
        <property type="protein sequence ID" value="OXR45184"/>
        <property type="gene ID" value="B7C42_03142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="78" mass="8318" checksum="5BDCAED5B01EBA75" modified="2017-10-25" version="1">MAAAQEESPQRLAPGALRGEVEDHLRDSPDTEFTPHEIGKVLGRSSGAVHNALVKLTTLGTARQTCTRPKKFALAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8I5</accession>
    <name>A0A231H8I5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_8</name>
        <name evidence="2" type="ORF">B7C42_03117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45159">
        <property type="protein sequence ID" value="OXR45159"/>
        <property type="gene ID" value="B7C42_03117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31610" checksum="A7C8A0346194BAD7" modified="2017-10-25" version="1">MNQAATMDAYAGGAPVRDGWPGPPLEPKRASGRAWYHRLFRHLATTTRLSIGTIGRSAQLSIEVVRFTFVDTVRLRLPMEEVLTQTWALLKVTALPALLMAIPIGAEVSVQVGGLMNQVGASSLAGAASGLGVISQGAPMATGLLMSGAAASAVASDLGARTIREEIDAMRVMGIDPVERLVMPRFVAMIFIAPILCVIVIAAGVFAGLTIAVTVNHVVPGSFWQSLGAFATTTDVVFAIMKALTFAALVVLVASLRGLEAKGGPRGVADAVNASVVLSVVCIFIANLVITQLQSMFFPAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8W1</accession>
    <name>A0A231H8W1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45166">
        <property type="protein sequence ID" value="OXR45166"/>
        <property type="gene ID" value="B7C42_03124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="27118" checksum="30960A311A10E470" modified="2017-10-25" version="1">MSHAGPAVLLAVFGVPAVVALIYAVVVAGRRRDPLPVASCFGALLCALNEPIFDVLGKIVYAQNHWMAFAALGRSIPWFLVIGYVPWVGLLPYLIARGMADGWSRRKLYLVAAAGVSSVVGVELINLWLRAWEYYGDPPLKYFGGVAAMAAVPLAGGYLIYAVADGLHGVGRAVVGFLVPAMVLPMIFAATGWPLYIALYTDAHGIVSWLAIAMLGVLIVAAVAGVAELAHRTHAAEATKLWGPTTGRVSDAAGLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Z9</accession>
    <name>A0A231H8Z9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776720.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45300">
        <property type="protein sequence ID" value="OXR45300"/>
        <property type="gene ID" value="B7C42_02425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="45926" checksum="570564B7AF265CF4" modified="2017-10-25" version="1">MASGDIVPIELGLTDGDLVTLWAPRWRDGDDEWEAFLGHEDELYGFDSPAELAAFIRTNDDNDLVDHPSWKVVVGLSAAELEPQEEHVFDLVGVPELAAGEPDPETIAELEETLEMVRTIGEVCELEVVTKFFGSHPVLGALPAGVTAFVGRDGEQLWDQVGNAIAKDWDQVVDAIDSVVASPEVDAEALAVAEAELLAAEENVVDAEDVADTDDDDIEPVDLDEDEDTDEDDDEDEEETFWHEVGIDPVKIVTSEGEFFTLRCYLDDEPVFLGSNGTITVFPSERALARYLADDHDHDLARVSTYGEVRTAAVDGSLEVEVTEENVYVLPGLADDLGQGPKSVDIDQLDLAVELFTDAADYLGDDSVEQALAKSTPLGWYVSYLLEPDPTRLAPSPPFTAEAESWRALEQAFENRLEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H901</accession>
    <name>A0A231H901_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ESX-3 secretion system protein EccC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eccC3_1</name>
        <name evidence="7" type="ORF">B7C42_02559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45434">
        <property type="protein sequence ID" value="OXR45434"/>
        <property type="gene ID" value="B7C42_02559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="462"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="826"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="485"/>
            <end position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="844"/>
            <end position="851"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1148"/>
            <end position="1155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1348" mass="146498" checksum="944C078F5BE1C703" modified="2017-10-25" version="1">MSTVRFQRRARREVPRSPGGEVTLQPPPEIPRAIPGSLMGKLMPVVMVVGMVGMMAIMFTRGGGIASNPMSMMFPMMMVFSMVGMFAGQGGKGQKAAEANEDRKDYLRYLDQVRKDVDETASQQRAAVEWSHPEPGLVWMLAGTSRMWERRPGDKDFCHARIGLGGQRLATRLVSPETGPVEELEPIAAVSLRRFVRTHSTVPDLPTAIAVKGFATIQLNGDRAQARDMTRAMLLQLCMFQAPDQVLVAVVCGPDTAAEWEWTKWLPHTQHPDSQDGVGTERMVYGSVRELAEGLNPLLHNRVRYSRNQPANQNLVHIVIIVDGGLLEAEEDSLRESGYEGVTIIDLCSYAPRLAVSRGIQMVVENGECVGRGATGNMERFALIDRISARQAEQVARRLAPFRVAPVQRGGDTVVEENAEVISSWAQLMGLGDIGTFNPENGWKPRYGRDRLRVPFGVGADGLPVYLDIKEAAENGMGPHGLCIGATGSGKSEFLRTLVLSLLATHSPDQLNLVLVDFKGGATFLGLEGVPHVAAVITNLEEEADLVDRMKDALAGEMNRRQEVLRQAGNFANVSEYEKARAAGADLDPLPALFVVLDEFSELLSQHPDFAELFVMIGRLGRSLHVHLLLASQRLEEGKLKGLESHLSYRIGLKTFSANESRQVLGVPDAYNLPNSPGGGYLKSDSGEIQRFQASYVSGAYVGGGAQREVTQAGIVGGEIDIHARPFVAGHVAFRKSDRIPLPPEPSAVEEVQQDESTEKISNLGMLVARIQGHGRTAHEIWLPPLDAAPTLDQLIPRSILTGEYNPVASLRTAIGIVDRPYDQRRDPMVVDLSGARGNVAVVGGPQSGKSTALRSLVMGMSLTHTAEQVQFYCLDFGGGTLSGLEGLPHVGSVAGRLDVDKVRRTISEMTTIVRQREMRFRQLGIESMADFRRLRGTDPASSPAAAGAHEDPFGDVFLVVDGFGSIRQDFDSLEQPIMNLATQGLSYGVHIVIALNRWAEARPALKDQIGTRIELRLGDPMDSDLGRKVASLVPQGRPGRGMTPDALHMLTALPRVDGDSNPESLGAGVADAVQRLVASTPGRPAPRVRMLPEVLNRDELLHNVLGGWPGAVDQYTRCVQIPIGLNESELSPVFLNMAEQPHVLIFGDTECGKTNVLRNIILNIVASNTPENAKLIIGDYRRTLLGVVEGRHVAGYAPSAEMLETMMRDLVGVLKARMPGPDITQQQLRERSWWSGPEVYVIVDDYDLVSTPSGNPLSILTEYLAQAKDIGFHLIIARRSGGASRALYEPLIGRMKDIGTIGLLMSGNRDEGALLGNVRLSEMPPGRGTLVARSGNSLIQTAWSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H917</accession>
    <name>A0A231H917_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">drrA_4</name>
        <name evidence="6" type="ORF">B7C42_02638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45513">
        <property type="protein sequence ID" value="OXR45513"/>
        <property type="gene ID" value="B7C42_02638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="325" mass="34269" checksum="1C684CC504EF11C4" modified="2017-10-25" version="1">MVSNSMGGPADTDDAIVVDGVEKTFGAVRALRGISFSAPAGSLLGVLGPNGAGKTTTVSVLSTLIRPDAGRARVAGFDVVTQAAQVRSSIMLTGQYAALDEMLTGRENLVLFARLLGMRRKAAAQRAEELLEQFALTEAAERRVGQYSGGMRRRIDIACGLVRPPRVVFLDEPTTGLDPVSRQSLWALVRSLKEQGVTILLTTQYLEEADALSDNIIVVDKGTVIAEGTADQLKARSGDSYCEVVPVDAADVPAVAATLANLGEVTIAESRDRVSVPAPGGAVTLSEALDRINTAGIELIDIALRRPSLDEVFIQLTKPAEEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H926</accession>
    <name>A0A231H926_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pknK_3</name>
        <name evidence="9" type="ORF">B7C42_02490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45365">
        <property type="protein sequence ID" value="OXR45365"/>
        <property type="gene ID" value="B7C42_02490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="39833" checksum="19BF61649F16F4C9" modified="2017-10-25" version="1">MTERARPIVGPDYLVAGRYRLQSKLGGGGMGAVWLATDRLLNREVAIKQVLTTAGLSEAEATEVRNRIVHEGRVAAKLSHEHAIAVYDVVLEAGEPWLVMEYLPSRSVAKALALADTLSPIEVAQIGAQVADALAAAHAAGIVHRDIKPGNILVADRGSEVGMAKLSDFGISSAGEAFDEPEDVITGTPSYLPPEVARGAQPGPASDVFSLGATLYTAIEGHPPYGFDDDNDVIVTRAAMAQIIPPTRSGPLTQVLLHMMEPAPQRRPTMAEAREEILTAAFGPGTGPYILGAPIRTDDGTIPAWAARNSAAGLRSPHSAPLPRPPRVAAAGAVAQQPKLGKSKLVDIDFTKFGPNAAPLAIAVGLLIGLLILIVVLVAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H938</accession>
    <name>A0A231H938_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_02465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45340">
        <property type="protein sequence ID" value="OXR45340"/>
        <property type="gene ID" value="B7C42_02465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="6">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="158"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="30930" checksum="5BC971E2C659DAC5" modified="2017-10-25" version="1">MEFDDAGLNVWSDEERFEVTRERIAEYAAATNDPIPAHLSGDIASPVFAIVPVFEAMMMPVIDVVPMDIFGRVVHGEQDFHFHRPIRPGDRLVSRAKAVGYEGRENGTTITILIECRDSDGELVNEQYLTAFFRNIDVGKRVGESAPPHKFDPGLEARPPLARVAAHVDDDQTYRYAPASGDPVPLHLDEQVAKDAGLPGIIAHGLCTMAMSSWAVLTEVAGSDVQRLKRFAVRFSKMVFPGDDLETQIWKTGSTGSDTTYAFRTARGTDLVLTDGLAVVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9B1</accession>
    <name>A0A231H9B1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)H dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="6">1.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lpdA</name>
        <name evidence="6" type="ORF">B7C42_02412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498407.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45287">
        <property type="protein sequence ID" value="OXR45287"/>
        <property type="gene ID" value="B7C42_02412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="3"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="348"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="467" mass="49036" checksum="168FB14180F41487" modified="2017-10-25" version="1">MARIAIIGGGPAGYEAALVAAQHGATVTVIDSDGIGGACVLWDCVPSKTFIASTGVRTDLRRARDLGITLHVAQAQVRLSEVNSRVKALAQAQSSDIRSKLQAAGVTILNGRGQLIDQIAGLATHLVRATLADGTERVMEAEIVLIATGASPRVLRGAEPDGERILTWRQLYDLKELPETLVVVGSGVTGAEFVSAYTEMGVQVKLVSSRDRMMPGEDADAALVLEDALAERGVELVKQARADAVERTADGIVVKLSDGRTVTGSHALMTVGSTPNTQDLGLERIGIELDRGGYLRVDRVSRTAATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVQPIRLKTVASAVFTRPEIATVGVSQTAIDNGEVPARTVMLPLNTNPRAKMSGLRRGFVKIFCRPATGVVIGGVVVAPIASELILPIAIAVQNNLTVNDLAQTFSVYPSLSGSVTEAARQLMRHDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA55</accession>
    <name>A0A231HA55_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45750">
        <property type="protein sequence ID" value="OXR45750"/>
        <property type="gene ID" value="B7C42_02042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18043" checksum="B903A52881A3BC8E" modified="2017-10-25" version="1">MIPPDRTDDGAPNSTVALGRAEAMRLLAGIAYGRVVFTRDALPAIRAVNHVVEADGRVVVRTRLTSRLTSAIRADSGVVVAYEADEIDPGTHTGWSVVVTGLARPVADPHRVARYERMLRPWTAATMDTVVEIEPTIVTGIRLVGAPESPGPPAPPTPSPKAEKNDLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA58</accession>
    <name>A0A231HA58_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45719">
        <property type="protein sequence ID" value="OXR45719"/>
        <property type="gene ID" value="B7C42_02011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="9772" checksum="9EF93AABEA89127D" modified="2017-10-25" version="1">MAALRPGEQLASTVCGTKVVVVRAPADADPVVTCGGSPLVPAASAPPVAPAAGEPVTLIGKRYVDAAGTVELLCTSSGSGELSCDGAPMTIKAAKALPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAB1</accession>
    <name>A0A231HAB1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative S-adenosylmethionine-dependent methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45781">
        <property type="protein sequence ID" value="OXR45781"/>
        <property type="gene ID" value="B7C42_02073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="51"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="20816" checksum="F9218757C33F5BCD" modified="2017-10-25" version="1">MLGDEPISDAYAANAEFWIRIVRDDLDPYRSGLTDPALLALIGDCAGLHILDAGCGEGCLTRELITRGAGFVDGVDTCAEFVAAAASHPAHDPARARFRQADVAALPLPDDSVDLVVASRLPHGLSDPGRRFVEFARVVRPAGRLVMVTMHRATALRGRGDALPRRLRASVVFTGSDDRDAHHRRIRDHRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAM7</accession>
    <name>A0A231HAM7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778836.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45920">
        <property type="protein sequence ID" value="OXR45920"/>
        <property type="gene ID" value="B7C42_02212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="20145" checksum="47CF9DDDBFC6ED51" modified="2017-10-25" version="1">MTVSYASVFTPMAAELPPDTDVDAIVLDLADNHVAAPESKNQDKLAEIADQARAHGIELNIVVVKGNPGRDSDLRDLATTLGKSEHGTVVVFSDDWIGTYSDSINRARLEWAEDKAKYQGGHTATAAQIFVDRLEAPEKVSWTAITSVVLAGTVLTIGGLYYIKSRRASRERAAVAADAATNPPVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAV8</accession>
    <name>A0A231HAV8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethyl sulfoxide/trimethylamine N-oxide reductase</fullName>
            <ecNumber evidence="6">1.7.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dorA</name>
        <name evidence="6" type="ORF">B7C42_02303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.3" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR46010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46010">
        <property type="protein sequence ID" value="OXR46010"/>
        <property type="gene ID" value="B7C42_02303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050626">
        <property type="term" value="F:trimethylamine-N-oxide reductase (cytochrome c) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02793">
        <property type="entry name" value="MopB_CT_DMSOR-BSOR-TMAOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041954">
        <property type="entry name" value="CT_DMSOR/BSOR/TMAOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041460">
        <property type="entry name" value="Molybdopterin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18364">
        <property type="entry name" value="Molybdopterin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Molybdopterin" evidence="3">
        <location>
            <begin position="48"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="4">
        <location>
            <begin position="619"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="766" mass="83753" checksum="25E186523582F83B" modified="2017-10-25" version="1">MVTHMTHWGAFDAVSDGERLTAVRPWPGDPEPTPLIGNVASAQHHPTRIDRPYVRKTWLDHGPGAPGRGGDAYVAVSWDRALDLLSGELRRVYTEFGPEAVYGGSYGWASAGRFHHAQSQLHRFLNCLGGYVRHVNSYSLGTSTVLLPYVVGDLFALLGRFTAKSVIADHTELVVAFGGISPKNAAVNPGGVSRHHNRDWIERARRRGCRFVTVAPLRDDTADIAEAEWIAPRPGTDTALMLALAQVLDADGLTDTAFLNSHTVGYEHFARYLRGTADGVVKDPAWAAAISGVPAERIRTLAHEMAAARTLVTVSWSLQRAQHGEQPTWLGVVLAAMLGQIGLPGGGFGHGYGSSASIGEPTRTLPLPRLPQGANPIDRFIPVARIADMLLAPGTPFRYDGRELRYPDIRLVYWAGGNPFHHHQDLARLRRAFDRPETIVVHDSFWTATARHADIVLPATMTIERDDYGTGDNDAILFPMPALTRPHGQARDDYDILAELSERLGTGKEFTEGRSTGEWLRHLYRQWLSDLGERGRDFPDFDRFWSGSGIDLPVADPPQVVFADFRADPRAHPLPTPSGRIEIFSETIAGYGYPDCPGHPVWLEPDEWLGSAAAHRFPLQLVANQPRTKLHSQLDVGAHSRSVKIRDREPVRLHPSEARARAVADGDIVRLYNDRGSCLAGLVVDDAVAPGIAQLSTGAWYDPDPADPSFCRHGNPNVLTADRPSSTLSQGSTGQLALVQIEAYHGPVPELTVLTPPPIVADHDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB30</accession>
    <name>A0A231HB30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicarbonate transport ATP-binding protein CmpD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmpD_2</name>
        <name evidence="5" type="ORF">B7C42_02249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45956">
        <property type="protein sequence ID" value="OXR45956"/>
        <property type="gene ID" value="B7C42_02249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="30869" checksum="976C7C205508178F" modified="2017-10-25" version="1">MSVTAIKLALDGVRKEFPSRGAGTPFTALENITVDVRDGEFLVLVGPSGSGKSTLLDLLGGLTRPTHGQILLDGRPVTGPGLDRGIVFQQYALLPWRTARGNIEFGLEAKRVRRRERRRIAEEYLELVGLTGFGDRYPHELSGGMKQRVAIARSLAFDPEVLLMDEPFAALDAQTRESLQDELLRIWRTTGKTILFITHDINEAVYLGQRVAVLTSRPGRVKAVIDIDLDRDIDPDADIRSSEHFSEVRHRIWSLLHDEVARAQGLEQADLAATDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA1</accession>
    <name>A0A231HBA1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-methylmercaptopropionyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="10">1.3.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dmdC_2</name>
        <name evidence="10" type="ORF">B7C42_01189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.-" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781515.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46223">
        <property type="protein sequence ID" value="OXR46223"/>
        <property type="gene ID" value="B7C42_01189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="288"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="474"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="611" mass="66648" checksum="5DED27EA32CB7C07" modified="2017-10-25" version="1">MGHYKSNVRDLEFNLFEVLGIGSVLDSGAYGDLDTDTVKNIIDEVRRLAEGPVAESFADADRNPPVFDPTTHSVSIPESFKKSFKAYQEAGWNKVGLNEELGGLPAPRSVVWALNELILGSNPAVAMYAAGGPFGQIFWNNATDEQKKWAEIAVERNWGATMVLTEPDAGSDVGAGRTKAIQQEDGSWHIEGVKRFITSGDSDDMFENIFHLVLARPEGAGPGTKGLSLFFVPKFHFDFETQTLGERNGVFVTNVEHKMGLKVSATCEVTFGGHGVPAKGWLVGEVHNGIAQMFDVIENARMMVGTKAIATLSTGYLNALDYAKQRVQGADLTQMTDKTAPRVTITHHPDVRRSLMTQKAYAEGLRAIYLYTAAHQNEDIAQLVSGADKDLAFRVNDLLLPIVKGVGSERAYQYLTDSLQTFGGSGFLQDYPIEQYIRDAKIDSLYEGTTAIQAQDFFFRKIARDRGVALAHVAGQVQKFIESEAGNGRLKGERKLLATALEDVQAMAATLTGHLMGAQEDAKELYKVGLGSVRFLMAVGDLLIGWQLLRQAEIAIKALDNGATGSDEAFYTGKVAVAQFFARNVLPELTATRTVLSNLDNDVMELDEAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA3</accession>
    <name>A0A231HBA3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent hydroxymycolic acid dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd2_1</name>
        <name evidence="2" type="ORF">B7C42_01056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46092">
        <property type="protein sequence ID" value="OXR46092"/>
        <property type="gene ID" value="B7C42_01056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="27849" checksum="E3590D740EF89CE2" modified="2017-10-25" version="1">MRLGTFLPTSTPDPQRPILGDVGAAARFAEEVGLDSVWSTDHLVASAPILESSVTLATAAAVTERIHIGYGVLLLALRPAAWAAKQVSALQYVSGDRLLLGVGTGNPAHGDIGWRAAGLPFADRGRRTDENLRVLPDLIAGRPAVLPDGTEVTLAPGATVPPILVAGDGPRARRRAAEFADGWLAIGLAPQEVATATKELSEFAASFGRATPTVSVVTPLPADPGEARDLFDAYTEAGVDHLLTAPRDADWHRGYEFVAAIRTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBD7</accession>
    <name>A0A231HBD7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxygen regulatory protein NreC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nreC_1</name>
        <name evidence="5" type="ORF">B7C42_01094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46129">
        <property type="protein sequence ID" value="OXR46129"/>
        <property type="gene ID" value="B7C42_01094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="227" mass="24499" checksum="2165D853896A3B7F" modified="2017-10-25" version="1">MSTAEAATGRHAEPLRIVIAEDSAILRDGLAGLLTDRGHEIVAMVGDAIRLSEIVAETRPDVAVVDVRMPPSFTDEGLLAAIELRSKFPGTGVLVFSQWVETRYATELLTGGAGGVGYLLKDRVADVREFVDALQRVATGGTALDPEVVSQLFGAARQQDSLARLTPREREVLELMAQGLTNASIATTLTVTERAVEKHIGNIFLKLDLPPSDTHHRRVMAVLRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBI5</accession>
    <name>A0A231HBI5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46179">
        <property type="protein sequence ID" value="OXR46179"/>
        <property type="gene ID" value="B7C42_01144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="7"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="36690" checksum="713CE2AC1EF4A67C" modified="2017-10-25" version="1">MPANPSNPHDAYFRRVLSRPADAACELRAALPAAVTDRIDWDTLRLQSGSFVSADLRSRYSDLLYRTRLDGHPAYIYLLIEHQSRSDHFMALRILEYVVNIWNQHRNHRPEERTLPAVIPLVVHNNHSGRRWNAPTEVAELVDLEPSTREALQPYVPRLRFLLDDVAALDLPALLARDLTPATRVMLTLHKIAPRETGVGADIISLIDDLRALLSGPDGKVEFQAAMTYVMTVGDTAEADLVPVIDQLGPPAKEIFVTTAERLRAEGEARGEARGEARGRAEALIELLTLKFAPLPTHITETVHAGTTEQVRTWTARILTATTLDEIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBK0</accession>
    <name>A0A231HBK0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46260">
        <property type="protein sequence ID" value="OXR46260"/>
        <property type="gene ID" value="B7C42_01226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="537" mass="55995" checksum="88D753664F1CC068" modified="2017-10-25" version="1">MPDCEVPGASVELNGRRAGGTGLDPEVLAVVERWNPQGSALLRAVPADPGPNSAAPHGATAAGSEPGVAQPVPVTVIGPDDANTTLLRTELSRFEPRVALTDPVTDPATLLAATDFGPGSGPAVALVLVDPGAAVGAALLDPVTRLQAVGTRILFAMNGVHAHPDWRSVLDRDTAMLARALGAEPEILPVSARLAVAGRGNGDAALLDRSGLAALHAQLSAAVGVRGGPDQLAGVTERVLADTRARVLAQIEALRSGSTVADLRAERTAALAGRDGGRAQALAALRNRLQLARVDLTHEVGVRVRTVNATARADLDRLDRRSVRGYPELLQSAVNQATAELDAVVRHRLIELARQIEAVAGSEPQSALASPAPPTDPAPRVGPDPERRHRGVEDRLMIALGASAGFGLGRLIVAPLSLLPALDYATVPVTLALGAGVAWWVVQARGHLADRAHLRQWVTDVLVNVKAQLEQRVATALVEAESELTEQLVRASTARMVEADRRVAELEAQLRRTAAEQPARVAACERDLAILEAAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBS6</accession>
    <name>A0A231HBS6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor BepR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bepR_1</name>
        <name evidence="5" type="ORF">B7C42_01360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46394">
        <property type="protein sequence ID" value="OXR46394"/>
        <property type="gene ID" value="B7C42_01360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="20794" checksum="322686E391A26BA7" modified="2017-10-25" version="1">MKIRDRLLLAAERQFAEHGALDATLSRIRADAGASVGALYHHFPDKADLYRQVWANALADYQRTFWASIADSTDAESGVTAGVTEHLRWVTENQYRATILMSPRPPGVRDSDSNREFLTSVARWWRTHARYGTVRDLEFDLLYALWLGPAQEYSRQWVSGSIRTAPTDIAAELAAAAWKSLRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBU8</accession>
    <name>A0A231HBU8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46177">
        <property type="protein sequence ID" value="OXR46177"/>
        <property type="gene ID" value="B7C42_01142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7430" checksum="D9206D0A47D90E61" modified="2017-10-25" version="1">MSNDRLAEAQWFKSTHSSGNSECVEVAFLDHDMVGVRDSKNPSGPALIFTPGEWNAFVGGARSGAFDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC01</accession>
    <name>A0A231HC01_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46378">
        <property type="protein sequence ID" value="OXR46378"/>
        <property type="gene ID" value="B7C42_01344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="30392" checksum="6B4DF6D7FE457FD5" modified="2017-10-25" version="1">MARNQYADERWPEVAEEEYWADEPVSADDRWEPPPPRRAANPRVAEPSDERWETTPNRRRPAAEAEDDRWDSAPNRRRTGRLRVEVPPIVNPYAIVALVAALLGLFPVAIVFGLIAFSHPRGRVMAMSALLLGLAEVLVLAAALVLSGVTLPHTTLGTVPAALSTDTATSNTATSRTVAPTTVVTPPPTPPATTTAAPAGPVSAAKGEVCTQAQAGLIGSATDGTTLLCLHGSSGYRWTGPYSVSTAVYEGGAKCDPGLDKTARTPDGHALVCEGQGRSSIWSLWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC52</accession>
    <name>A0A231HC52_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative quercetin 2,3-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.24" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46428">
        <property type="protein sequence ID" value="OXR46428"/>
        <property type="gene ID" value="B7C42_01394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008127">
        <property type="term" value="F:quercetin 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="28977" checksum="8215B64E6231FB63" modified="2017-10-25" version="1">MSTLTTPHIDVHRAGDRMKTRVAWLDSKHSFSFGEHYDPENTHHGLLLVNNEDIVLPGEGFDTHPHRDMEIVTWVLNGSLVHQDSLGHAGVIYPGLAQRMSAGTGILHSEKNDSWRLPPEQGGTSPHSEAVHFVQMWVVPDEPGITPGYQQLEIDDELDRGGLITVATGMPRYRDRTAIAISSSHSALHVGRMPGAAGAAAGQVITLPEAPYLHVFVARGEVEMEGVGTLYEGDAVRMTRSGGQRIVAEVPAEVLVWEMHARLGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCA9</accession>
    <name>A0A231HCA9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46462">
        <property type="protein sequence ID" value="OXR46462"/>
        <property type="gene ID" value="B7C42_01431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="88"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="40492" checksum="0C00286FF434C0F4" modified="2017-10-25" version="1">MVAIVADLPRAARNIWAVSFGDGIEPYRPAPSTPISEQPHNRLLRYDREEPGTGNPVLLVPPLAVTPACFDLRDGQSLVRYLLGIGKQPYVVDYGDFDYGDRDLGLEHWTHGIVPDAVRRVAAEHGRPVDVIGWSLGGALAMIAAAAHADLPIGSVTGLATPFDQRRTPFLVPVRMAGRLTGGRGVALATRLLGGAPRELVRLGFRLQAFDRELTRPLFIARHASDTEALARMEAVDRFMATMPGYPGRSLWQIYRSLVLRNELAEGVIRLRSDLVVDLSKLTCRVLLIGSRTDMLVPAGSTRRGVDLLTGAAEVRFVEVSGGHLGLMVGPDAAGSTWPAIGDFLGDSSGGSAASDQIKPSSRARAMASARDPLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCV9</accession>
    <name>A0A231HCV9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dibenzothiophene desulfurization enzyme C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">soxC_2</name>
        <name evidence="4" type="ORF">B7C42_01732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46754">
        <property type="protein sequence ID" value="OXR46754"/>
        <property type="gene ID" value="B7C42_01732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="123"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="3">
        <location>
            <begin position="239"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="43628" checksum="A56F3FF708F9750F" modified="2017-10-25" version="1">MASTAPQQISDRDLDDIFGPVFDRIAAGAVAREVDRRLAYEEVDWLRQAGFGALRVPAEYGGFGVSVRQLFRLLIDLAAAESNLPQALRVHFSFVEDQLLAEPGPAREHWLRAAGSGALVGNAITEPGIGAVDRYRTRLTRGSGDDWLLNGTKYYSTGSLYADYILAAADRDGERVSVLVDANADGVRQSDDWDGFGQRLTASGTTEFNDVRITEERVLGPGYGAPGRTYATSYLQLVQLAVLAGIAQRAESDVRAWVADRTRSYTHSVADLPRHDPLVQQVIGKLSAAAFSARASVLAVADLLDGVLAAGAQDDAALDAVELASAQAQLGVIDTVLTATTQLFEVGGASITSEDLRLDRHWRNARTISVHNPAVQKARAIGDHLLNGTDLPYAWSAGSREAQVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCW3</accession>
    <name>A0A231HCW3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775138.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46537">
        <property type="protein sequence ID" value="OXR46537"/>
        <property type="gene ID" value="B7C42_01507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="10339" checksum="AD1CFEE217C96481" modified="2017-10-25" version="1">MVGLLGVQPEVVLAASAELDLLAERLTAAAALSGPATHVVPAGAEEVSVAAATHLNEGALSHDRAAAQAILELHHAAAILRQQLASYLAEDAINAAGTAAIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD35</accession>
    <name>A0A231HD35_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46841">
        <property type="protein sequence ID" value="OXR46841"/>
        <property type="gene ID" value="B7C42_01819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="93" mass="10116" checksum="EFBBF19A847BFE70" modified="2017-10-25" version="1">MTNPVFHGPLANPISPERMHREIHAARHAACTERTCDMLSSCRNILTTLGHDPDAATTAHCAACRTGPTMKTPRSQDVPTPPSTLPTECRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD40</accession>
    <name>A0A231HD40_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent monooxygenase, reductase subunit HsaB</fullName>
            <ecNumber evidence="3">1.5.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hsaB_2</name>
        <name evidence="3" type="ORF">B7C42_01737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.36" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497209.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46759">
        <property type="protein sequence ID" value="OXR46759"/>
        <property type="gene ID" value="B7C42_01737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036382">
        <property type="term" value="F:flavin reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="18515" checksum="7D021B56A260486E" modified="2017-10-25" version="1">MSDLIEIPSDSTGLRRAFAHFPSGVVAVCAEFDDVPAGLVVSTFVPVSLDPPLVSFCVQNSSTTWPKLVGAQRLGLSLLSAHQDEAAQRMSSRHGDRFGDVDLHRGEGGSIFVGGAAAWLEGTVHTQVSAGDHQVVLVQITRLATRSQHEPLVFHGSRFRRLHPGADPASAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD63</accession>
    <name>A0A231HD63_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigJ_3</name>
        <name evidence="8" type="ORF">B7C42_01719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775351.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46742">
        <property type="protein sequence ID" value="OXR46742"/>
        <property type="gene ID" value="B7C42_01719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="32685" checksum="98F55324FCCB4C49" modified="2017-10-25" version="1">MSERIDGATEAFVTHRNLLFTVAYEMLGSAADAEDVLQETWLRWVDVDLDEVRDQRAYLVRIVTRQALTRLRTLGRRKESYVGPWLPEPLLTAPDVAEDVELADSVSMAMLLVLETLAPTERAVFVLREVFDLSYDEIAAAVDKTPAAVRQIAHRARAHVAARRPRGVVSADESRRAVEAFQQAIETGDLQHLVDMLAPDVVLLGDGGGVVQAVLRPIAGADRVARALRTGLPRLRAEATVEAVQINGCPALIVRIDGRIDDVVAMRLDDGRITGLYVVRNPEKLSRVEQQITVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE43</accession>
    <name>A0A231HE43_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">nei1</name>
        <name evidence="18" type="ORF">B7C42_00202</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777011.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47082">
        <property type="protein sequence ID" value="OXR47082"/>
        <property type="gene ID" value="B7C42_00202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="17">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="16">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXR47082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="29280" checksum="486535578C71E485" modified="2017-10-25" version="1">MPEGHTLHRLAKLHQQRFAGGVVRVSSPQGRFADGAALVDGATLTKAEAWGKHLLHHYDSGLTVHVHLGLYGTFTESPAPLSDPVGQVRMRMIGAGKSAATLYGTDLRGPTACEVLHAPEVDALTARLGPDPLRRDADPERASQRIRRSNRSIAALLMDQSVVAGVGNVYRAEVLFRHGISPQRPGRAVTAAEWDALWADLVALMKVGVRKGAIVVVRPEHDRGAPSYAVGKPRTYVYRRAGEPCRICGTTVAHAVLEGRNLFWCPTCQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEA0</accession>
    <name>A0A231HEA0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47027">
        <property type="protein sequence ID" value="OXR47027"/>
        <property type="gene ID" value="B7C42_00146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12514" checksum="B001DEB7D703E668" modified="2017-10-25" version="1">MADADDVRRIALGLPESTEAPHFDMPSFRVRKAIFATLPDPDHAHVMASEADIREAVAEYPDCCAEKWWGRRLSAVRVDLGAADTGLLSELLIDAWRHKAPRTLVRAFDAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEX0</accession>
    <name>A0A231HEX0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cysT</name>
        <name evidence="12" type="ORF">B7C42_00378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47256">
        <property type="protein sequence ID" value="OXR47256"/>
        <property type="gene ID" value="B7C42_00378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF8">
        <property type="entry name" value="PTHR30406:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="93"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="304" mass="31738" checksum="DFCD5C3781DAF44C" modified="2017-10-25" version="1">MTDSSTKADIGSSTDAGTPGPGVSGQQQKKQSAGPAWRSRLTGSAGSLGLAITVLWLSLIVLLPLAALTVHSFDDGWSGFWDAVTAPAALDALRVTVLVSVVVAVINVVMGTVVAWVLVRDDFPGKSFVNALIDLPFALPTIVASIVLLSLYGPQSPVGIHLNATQPGLVVALAFVTLPFVVRSVQPVLIEADKEVEQAAASLGANNLTIFRRVVLPSLAPAIISGGGLAFARAIGEYGSVVLIGGNIPRRTQMASQYIQQQIEVDRPVNAAAVSVALLAISFATLLILRVFSERTARKEQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF34</accession>
    <name>A0A231HF34_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclic pyranopterin monophosphate synthase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">moaA1</name>
        <name evidence="6" type="ORF">B7C42_00698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503553.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47573">
        <property type="protein sequence ID" value="OXR47573"/>
        <property type="gene ID" value="B7C42_00698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="37656" checksum="D83E0730DD74A56D" modified="2017-10-25" version="1">MAMPFRQSVRLGAYLAKQKLLRREKFPILVELEPLFACNLKCAGCGKIQHPHTLLKQRMPVEQAVGAIEECGAPMVSIAGGEPLMHPQIDEIVRQLLDRNKIVFLCTNAVLLPKHLHKFAPHRNFAWMVHLDGLRERHDASVCKDGVFDQAVAAIREAKAAGFRVMTNTTFFDVDSPQDVIDVLDYLNDELEIDHMQIAPGYAYEKAPDQEHWLGVKETHQLFAKAFADGRRKKWRLNHSPLYLDFLEGKVDFDCTAWAIPSYSLKGWQRPCYLLDDGYVATYRELIDDTDWNAFGRGNDPRCSNCMAHCGYEPTAVVATLGSLKETIRAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF82</accession>
    <name>A0A231HF82_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">xerC_1</name>
        <name evidence="9" type="synonym">xerC</name>
        <name evidence="13" type="ORF">B7C42_00657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47532">
        <property type="protein sequence ID" value="OXR47532"/>
        <property type="gene ID" value="B7C42_00657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="114"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR47532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="33372" checksum="29D9BB6409DCC79E" modified="2017-10-25" version="1">MDGLPGDLADLLEQYERHLLLGRNRSAHTVRAYLGDARSLLEHLCARSPDAAVGEIDLPLLRSWLAEQSAGGAARTTMARRASAARTFTAWLTHTGRLVADPGPRLGSARAHRILPAVLSEEQADAAMNAAESGAAQRDPMALRDRLVVEMLYATGIRVSELCGLDIDDVDRGRRLVRVLGKGNKERSVPFGLPADRALENWLNFGRPHLATADSGRALLLGRRGRRLNQRQARTVVHEVVSAVPGAPDLGPHGLRHTAATHLLEGGADLRVVQELLGHASMATTQLYTHVSIERLKRVHDQAHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFT1</accession>
    <name>A0A231HFT1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47744">
        <property type="protein sequence ID" value="OXR47744"/>
        <property type="gene ID" value="B7C42_00869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="35610" checksum="AC3A8671A439815D" modified="2017-10-25" version="1">MSAVETVRGPLDTAALGKVLMHEHVFVLGEEMRQNYPDYPNHWDEDARVADAVAKLRECAARGIDTIVDPTVIGLGRYIPRIQRINEQVDINIVVATGLYTYNEVPFQFHYTGPGLLFDVAEPLVELFVKDIREGIAGTEVKAAFLKCAIEEQGLTPGVERVMRAVGQAHVETGAPITVHTNVHNQSGLIAQKVLAEEGVDLGKVVIGHSGDSTDLDYLCALADAGSYLGMDRFGLDVLLPFEQRVDTVVRLVERGYAEKMVLAHDAACFIDWFSEEGKAAAVPNWNFTHISDDVLPALRERGVTDEQIDTMLVHNPRRYFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSH5</accession>
    <name>A0A231GSH5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000553">
        <property type="protein sequence ID" value="OXR39554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39554">
        <property type="protein sequence ID" value="OXR39554"/>
        <property type="gene ID" value="B7C42_08378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="45" mass="4774" checksum="A7E654C1A8550950" modified="2017-10-25" version="1">MVGVGAPVNERLIQLIVAAEQGGRRDWPSGELLAELRAAGSTTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSN7</accession>
    <name>A0A231GSN7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000214">
        <property type="protein sequence ID" value="OXR39592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39592">
        <property type="protein sequence ID" value="OXR39592"/>
        <property type="gene ID" value="B7C42_08340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="73" mass="7310" checksum="23948A37F23E99FE" modified="2017-10-25" version="1">MGRQARIARLRQVSGLAAPVVLTSATTLVLGVTHTALLGHHSIEALGVAALVLSASVPVTIAGARLSCGPARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTE2</accession>
    <name>A0A231GTE2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782308.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39886">
        <property type="protein sequence ID" value="OXR39886"/>
        <property type="gene ID" value="B7C42_08032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="26294" checksum="CFFBB07B0AF00C75" modified="2017-10-25" version="1">MSCTWPVSYTCLPDVASPEDAAQLQAAVDTAVNVLWSFTGRQYGCCPLIVRPCPQQREHHLFWIPGYAWYPVLDAGVWQNIACGCGPTCTVGGPGVVHLPGPVCSVTEVRIDGATVDSSTWVLEGDRLYAASGQWPSQDLSRPAGSPGTWSVEFLQGYPPPVGAAAAVGALALEFWKLCRGEKCRLPRGVESVSRQGVSMKIADPTAMFENFQTGIPEVDLWIAAVNPHRLAAPPAVLSPDYRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTF4</accession>
    <name>A0A231GTF4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39903">
        <property type="protein sequence ID" value="OXR39903"/>
        <property type="gene ID" value="B7C42_08008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="52" mass="5875" checksum="DD22B8BAB6D51576" modified="2017-10-25" version="1">MTTLVIVCVVLAPVIYAVIFLWPQRIPKDRTVAAIRHRIESESETRGHNNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTM2</accession>
    <name>A0A231GTM2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitronate monooxygenase</fullName>
            <ecNumber evidence="3">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.16" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39974">
        <property type="protein sequence ID" value="OXR39974"/>
        <property type="gene ID" value="B7C42_07953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375771" evidence="1">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="NMO" evidence="2">
        <location>
            <begin position="81"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="33089" checksum="1AE8AE26643CD417" modified="2017-10-25" version="1">MALPASLTNRLTIPAIAAPMTSVSGPDLVVAACRNGVVGSFPTHNAATTEELDGWLEQISATLRAHTGPTAPVAPNLVVHRTNARLRTDLDCLIRHGVELVITSVGSPKPVVAPLHEIGCRVFADVSSMAHVERALEAGVDGLVLLTAGAGGQTGWANPFAFTRAVRARFDGPIVLAGGITDGTSILAAQVLGVDLVYLGTRFIATTESLAEDGYRAALVESTLDDVTLSTRVGGIPASLLASWLAREDLAGPGPQDSNGFEQDRLLRNRAAWSAGHSVAGVDAITSVAELVETIAEQYDRARAALLSTLTGPRSLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTQ2</accession>
    <name>A0A231GTQ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000046">
        <property type="protein sequence ID" value="OXR40007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778661.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40007">
        <property type="protein sequence ID" value="OXR40007"/>
        <property type="gene ID" value="B7C42_07927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="14131" checksum="4C6D035AB8E336BC" modified="2017-10-25" version="1">MTGTPTAPVTLSLTAIRVTDLARSTQFYTACGFVEETSFSTDTFDAVILRAGTAGVELIAPHGNPAAPDHGTMFTKLVVNTEDVAGLLMAACAHGGAEEMPATTLARFGGRTIGKVRDPDGYLVEVVSPTGKTSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU36</accession>
    <name>A0A231GU36_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778631.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40137">
        <property type="protein sequence ID" value="OXR40137"/>
        <property type="gene ID" value="B7C42_07801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12693" checksum="7FD6786DBB62E99C" modified="2017-10-25" version="1">MSDSTIYIIDRIVLKPGHARAFIDAYLSEYAPGARQRGLTLDRVLVSPPAWIDAESNVVTATWTVEGPQQWWAAAVQGRHDPGYAQWWQSVSPMIVERSRSMAAAADAVEGLCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU87</accession>
    <name>A0A231GU87_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778632.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40138">
        <property type="protein sequence ID" value="OXR40138"/>
        <property type="gene ID" value="B7C42_07802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="107"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="229" mass="25320" checksum="8E1E181611989055" modified="2017-10-25" version="1">MYKVTRLLHLNDTGDRAAVLRTVTAAADSIHARYGLIAPTLPGARNGGDILVHLQFESESEWSRWRAPIDAATTDSSIRHVDAAEYVGGSPGQDRTGRRGPSEPASVYRTLLLRVDDSASPTELRRFEHAMLQMPAHLPGIRAWQLSRVTHAAGSTAWTHVWEQEFADIDTLLGPYMNHPVHWGHVDRWFDPECPEHIVKDRVCHSFCAMSAPVISDTTPTALSAAKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUB8</accession>
    <name>A0A231GUB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518273.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40224">
        <property type="protein sequence ID" value="OXR40224"/>
        <property type="gene ID" value="B7C42_07739"/>
    </dbReference>
    <dbReference type="GeneID" id="66719304"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019675">
        <property type="entry name" value="DUF2550"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10739">
        <property type="entry name" value="DUF2550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="15600" checksum="3E15EFF868C62618" modified="2017-10-25" version="1">MVLLIILVLLLVGVALVSLYRLIMLRRGGTAAILRVLPAQGGQGWRHGLIRYGESRLVFYKLTSLKVGPDSTIRRLGIEVVDRRSPVGDEYDIMTDDIVVIAVSDGDGSYELALDRPALTAFLSWVESRPSERIRRRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUF2</accession>
    <name>A0A231GUF2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40253">
        <property type="protein sequence ID" value="OXR40253"/>
        <property type="gene ID" value="B7C42_07678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="8283" checksum="94FBD67802AE84EE" modified="2017-10-25" version="1">MTVDLSAVSLPEDLVPEDLIPASTAASLVQVDPKTIKNWIKAGELRGWLVNGHHYRVRRSEVLGLVRPVATVSGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV00</accession>
    <name>A0A231GV00_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40301">
        <property type="protein sequence ID" value="OXR40301"/>
        <property type="gene ID" value="B7C42_07639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="31666" checksum="AFEB0FD406F8E0B9" modified="2017-10-25" version="1">MDATISTPATSRDVVAHPRSFRRSGGRRESEPHERRYILSLLRLRRLRAECSCNPRFGDLDGVRHRLLLRCRYEYVGSGAGHRFVSHRANPVQLSRTVIGTRACLPWRWALDSLRIGAGSACRRMRRRQLRRACRAPPRCVVGVASRRVAWFRSFSRVAVVVHVGFRGSAVATLVADSPWCACGLFGVARRGVLPSMRHVLLALRTGRRDPGAASDAPGRFPGDRLERRGLSQRRVISTDTGVVGHYCRQAELAGGPSARRSARRAIARMPVSAIAPPIPQTAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC9</accession>
    <name>A0A231GVC9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rocA1</name>
        <name evidence="9" type="ORF">B7C42_07392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40583">
        <property type="protein sequence ID" value="OXR40583"/>
        <property type="gene ID" value="B7C42_07392"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="58"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="545" mass="59002" checksum="DDE99A1EB4AC215B" modified="2017-10-25" version="1">MDAVTVVPTPANEPVHSYAPGSRERELLIGKLAEISGQTVDVPLVIGGKHRPGTGPRSEIVMPHRHAHALGTYADVTQEEGRAAIEAATAAAPQWRALPFTERAAVLLRAADLLAGPWRETVAAATMLGQSKSAYQAEIDAPCELVDFWRFNVAFASHILAQQPESSAGVWNRMDYRPLEGFVYAITPFNFSAIAGNLPTAPALMGNTVVWKPSPTQTLAAYYTMRVLEEAGLPPGVINLVTGDGIELSEAALTDPRLAGIHFTGSTRTFQHLWQRVSSNIGRYHGYPRLVGETGGKDFVLAHRSADPDALRTALIRGAYEYQGQKCSAASRAYIPRSLWREMGDDFLTQVDELSYGDVADLSNFGGAVIDRRAYDKNVAAIERARSAGLGIPAGGTYDDSEGFFVQPTVLLADTPRDEAFTTEYFGPILSVYVYDDDHPEAFDAILAEVDSAAPYALTGAVFARDRAAIDRAAGTLRFTAGNFYVNDKPTGAVVGQQPFGGARASGTDDKAGSYLNLLRWVAPRTLKETFVPPTDYRYPHMESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVL2</accession>
    <name>A0A231GVL2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40595">
        <property type="protein sequence ID" value="OXR40595"/>
        <property type="gene ID" value="B7C42_07280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="11815" checksum="93FCF93A6033CC48" modified="2017-10-25" version="1">MDLVRELLRGAVPVHVLHHAAEQEVYGAWMAEELAHHGYPISPGTLYPLLHRLENAGLLTSTEHVVDGRVRRVYTATAAGLGELTRLRAVVAELSGEVLRPAPATGPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVY0</accession>
    <name>A0A231GVY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40774">
        <property type="protein sequence ID" value="OXR40774"/>
        <property type="gene ID" value="B7C42_07198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="28257" checksum="B9B9E9E2D8FB5B65" modified="2017-10-25" version="1">MTDASPGSAGPHALPESTPTAPARDRRPRRLGKVRQVVVSVMLAVMTAMVPLAFAPAMPASAAVAKPGVENAPARAAVTDLVGDHPWAVALPADFAAEAGYRPVVENGILVDPDGDCSSPIQLPAEFTEACKAHDLGYDMLRYAEQRQQPLQPWARQAIDATLQRRMHAACDMRTDTAARARCDVLATVATTGVDLNSRRQNYATPDPEFLFGTQLSGERLSDQLLHFGGPAAVGAVAAAIVGIVAWRRLRPDRLTAPNAIAEAGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW71</accession>
    <name>A0A231GW71_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40815">
        <property type="protein sequence ID" value="OXR40815"/>
        <property type="gene ID" value="B7C42_07099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="500" mass="53660" checksum="C8BCC769BF15DABF" modified="2017-10-25" version="1">MSITDIPAAGTEPPQPEQSPPDAAHESPPGSDRSRPSRSGPARAVQALAMRLHFYAGVFVAPFILIAAVTGALYAVAPSIESIVNRDLLHVDSTGPARPLSEQIAAGVAAEPTLALVAVDPAQHAGDTTRVIFSDPSLGESERRAVFVDPATATSVGDSVVYGSTGALPMRTWIDVLHRNLHLGDAGRLYSEMAASWMWIIALAGVVMWLRRSRGSARRLLWPDRSKSGRPRSVSWHAAVGMWIVLPLLFLSATGMTWSQYAGQHITSLRQQLSWTTPVVNTALPGAPMPSMPAGGEHAEHTGGHHMPMPVSADRAAQADNVLAVAREHGIDGPVEITIPAKDTTAFTVKERRLSGVYTQDAIAVDGKTGDVTDILRYADWPLVAELANWGIALHMGMLFGLANQLLLLATMIALITVIGRGYLMWWRRRPTRENSPFSFGRAPARGVLRRAPLWISVPLVAITVGIGWFAPVLGVSLLAFLIVDIVAGLIARRRRGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWB7</accession>
    <name>A0A231GWB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40868">
        <property type="protein sequence ID" value="OXR40868"/>
        <property type="gene ID" value="B7C42_07003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="33942" checksum="86F68DF4F36425F7" modified="2017-10-25" version="1">MSRVVVFDETGAPEVLRIADEPVGTPGAGEVRLRIEAVGINRLDQMVRTGMSPRPIRLPRARLGVEATGTIDAVGAGVQRWSVGDPVIVTAVPDMDTNGTYAEHLVLPADRIIARPAELDAIGAAALWVAYSTAYGALVEKAAMRPGDHVLITAASSAVGLAAIQIANQIGAIPLAVTRRTAKKDTLLAAGAAAVIVTDHDDVVEATQQHTGGAGADIILDSVMGPGLAELAGAAKPFSGTLVTVGWLDPRPAPYPASPITMIRYMSFEHTLDPCAVHRIAAFLTAGIRTGALQPTIDTVFTLDDIVAAHHHLEKGTHIGKIVATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWI2</accession>
    <name>A0A231GWI2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adhT_3</name>
        <name evidence="2" type="ORF">B7C42_07067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783767.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40932">
        <property type="protein sequence ID" value="OXR40932"/>
        <property type="gene ID" value="B7C42_07067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="32657" checksum="063CE37552A8C5FF" modified="2017-10-25" version="1">MRAARLHNFGEAPVVDDIDVPTRGAGQTLVRIDAAALGHLDMTVASGTFNIRPSLPHIGGTDGAATVVESDIYTPGTRVLVRGGGVGLTRNGCWAENLVAPDKAFTPIDADLPAAVAATFFLPTTTGYVAVHDIAQVRPGERVLVSGASGAVGSMAAQLALLAGAGEVIGVVPRPDQVELVPDGVRPVIGRGDELAERLGDGPVADVLIDTLGGDSLPPLLQRITPGGRAALIGYTLGTELTIDLPNWLLSDVKLLPVNMIHKGARQAELAPVLMTMLAAGDLRLAVQQFPLDEIADALRRMREGKVAGRAVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWL5</accession>
    <name>A0A231GWL5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5642 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40996">
        <property type="protein sequence ID" value="OXR40996"/>
        <property type="gene ID" value="B7C42_06962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041313">
        <property type="entry name" value="DUF5642"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18702">
        <property type="entry name" value="DUF5642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5642" evidence="1">
        <location>
            <begin position="63"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="237" mass="24218" checksum="EB45C6D49A0026FF" modified="2017-10-25" version="1">MSVPNPPASRRRRGFGHTVGYAALSCLLAACGSTVSGHPTAMRQSVVTRHIDGDLTAMLPGQDRFPAGYTTVVASGERAAAAAADLTAIPPGAQIDPPGCAPAPPDPAGIAATIGTDDRTRATITVVLSRTDEPLSALGDQLSRCPTVHARHGAIDRTITTRLLPPPPVDADDTVAFGRTVTGSPPGSSADPALRTLLGQIGDIRIETTAMTFGAAAPDTTGLDQVFTAAVAKVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWX6</accession>
    <name>A0A231GWX6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41123">
        <property type="protein sequence ID" value="OXR41123"/>
        <property type="gene ID" value="B7C42_06893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="41370" checksum="FE8FA77E9F0F2E15" modified="2017-10-25" version="1">MNSGEIDHIANIERFIEQLGGEEWLSQARPSETNPTPNPIALWVGDYRGGLRDPAGLEKNQSFLRLSRLAFYVSILKSASVANLDDRLDELHKGAGERVLSAVHEIQVAGEYVARGNSVAFIPETTTPTADIAVNGSMEVECKYKTGAFSSRDKNRMNLYKILNSKLQKLYHAGVEASGLVVEATFEVEPTREMIDEILAATRSCLRPVRSDPLRVTSSLLSYTITTIPGKQVVSDSLTIPHGQDVTFQTFQLGGTVAERPDGSLGFTRPIALGLRCKVEMDVVGTIRSSIKSAIKQLTGDCPGVVVIDVGDFLGTVDHSEVPGLTAAIEKIFQNNSRLSRLELVADYFAEIEGRLHLQRKVQYLENNAARRFAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX19</accession>
    <name>A0A231GX19_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator WhiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiB_1</name>
        <name evidence="4" type="ORF">B7C42_06766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41170">
        <property type="protein sequence ID" value="OXR41170"/>
        <property type="gene ID" value="B7C42_06766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325508" evidence="2">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="3">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="16563" checksum="388C453390CA6AC8" modified="2017-10-25" version="1">MSTIHSRRLPLGSPVPTALSPLPAPSATVRSAHRPPCADGPDDWDLDVGNPESWRAAVRICSGCPLLTECSQLAQTLITRGDGPRAMIWAGVAYDSAGKVVENLDRHRTAPIDHKRPLRIIRTGARPVCAEPAPPTPRRRIVLGHRLRPTGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXA9</accession>
    <name>A0A231GXA9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41212">
        <property type="protein sequence ID" value="OXR41212"/>
        <property type="gene ID" value="B7C42_06610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="16278" checksum="FE437FD00D8881AB" modified="2017-10-25" version="1">MTSTGSRIDSAIYVDRIRSVCAAVKAHDIETVLTYFDDACVFVNGVTGTTSEKPELVEFLKETWAVFPDYAPRPVVTYMQGNTLGALFEMAGTPPQAEGQAAPEQIRWLAASFSTFDPVTLKIVRDAYYVDEEAIQQQIAAAQHAETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXE6</accession>
    <name>A0A231GXE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin reductase</fullName>
            <ecNumber evidence="3">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcD_8</name>
        <name evidence="3" type="ORF">B7C42_06688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41290">
        <property type="protein sequence ID" value="OXR41290"/>
        <property type="gene ID" value="B7C42_06688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="323"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="427" mass="44933" checksum="870E88433BE7650E" modified="2017-10-25" version="1">MHTDLPTHTVVIVGAGQAGGTLAGLLRQQKFTGRVVMYGAEPVPPYHRPPLSKKYDGDDYVQWLRPESFYADNDIELHLADPVVSIDRAARTVTTRSGPTVRYDTLVLATGASPRALPVPGADLAGVLALRTLADATELRTAVLAGARIAIVGAGYVGLEVAAAARARGCEVTVIEREDRVLARVASPEFSRILTDSHLARGTRIVTGADVRAILGRDGRVRGVRLGDGTDIDCDTVIVGIGAAPEDSLARDAGLDCMAGIVVDAAARTSDPNILAIGDVTHRLHEGLGALVRLESIPSATEQARQAAAVITGEPVPAHEVPWFWSDQFDLKMKMAGVPAPGTAAVLRGDPRTGSCALFHLDIDGRARCVETVNAAADFMAGKKFIGTGARLDRSALADPATSLRHAARGVDHTPVAASDRAETQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXU4</accession>
    <name>A0A231GXU4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_06344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase IS21/IS408/IS1162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41453">
        <property type="protein sequence ID" value="OXR41453"/>
        <property type="gene ID" value="B7C42_06344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="108"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="46256" checksum="632DC3601592140C" modified="2017-10-25" version="1">MEDWAEIRRLYRSEGVSISEIARRLGIARNTVRAALASDRPPKYERKPAGSLTDEVEPQIRALLAEFPRMPATVIAERIGWRHSSSILRARIQKIRSEYAGVDPVDRVHYEPGRITQCDLWFPEAKIPVGHGQSRVLPVLVMTSAYSRWLTAVMLPSRQAGDLLSGMWQLIAGIGRVTKTLVWDREAAIGGTGKVTEPAAAFAGTLATRIVLAPPRDPEFKGMVERCNGFLETSFLPGRRFTSPADFNTQLSEWLVRANNRTVRAIGGRPVEVFDTDYAAMTPLPPVDPIVGLGHRIRLARDYYVRVDTVDYSVDPRVIGRFVDVTASPTAVVARCDGEVVAQHERCWAQRVVITDPAHVELARQLRAGLAADRDSRARAARHHADGHPVILRPLPDYDALFGVDFTPVPPTEASNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY33</accession>
    <name>A0A231GY33_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phthiocerol synthesis polyketide synthase type I PpsC</fullName>
            <ecNumber evidence="8">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ppsC_6</name>
        <name evidence="8" type="ORF">B7C42_06374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41482">
        <property type="protein sequence ID" value="OXR41482"/>
        <property type="gene ID" value="B7C42_06374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2016"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="2147" mass="227622" checksum="FAB538A5C9CF6549" modified="2017-10-25" version="1">MSDIAIVGIGCRFAGGIDSPETFWDFVVDKRDGVVEMPADRWDYRRYYDPEPRTPGRSYTKRGAFMTVDPWQFDPDFFGISPREATVLDPQQRLMLEVTWEALDDAGMAGRAAGSSVGVYVGGFVVDQSVIGVVGPALFHTDMHTPASASYTMLSNRIAYALDLVGPAITVDTACSSSLVAFHLACQALDNDDCRVALAGGVNVMLQPETFVLMCKGGFLAADGRCKSFDASADGYGRGEGAGMVVLKKLDDAVRDGDRIYAVVKATGSNQDGRTTAITVPNVDSQEALARTVCERSGLAPQSITYLEAHGTGTLVGDPVELRALGKVFGASTGRTESVGVGSVKATIGHTEAAAGVASVIKAALAIKHRTLPPQGWLDKQNPDIPFEELGLHVQTEAQPLSADAGPMSVAVNGFGYGGTNAHAILQEYVGPAPAAAGPHRHLGILPISARSTAAARALAGRFADLISAGADPDHLAEAAWTRMAHHAFRTGVLIGDSTEELVRELRGYAAGEGRDASRTIVSRAPEPVFVFSGMGPQHWRMGRELLAAGGVFAETAAEIDAEFRALAGWSIVDELRKPEDESRVTRTEVAQPANFLVQVGLVRELEQYGITPAAIVGHSVGEVSAAYVSGMLSLRDAVRVAYHRARLQATTAGTGGMLAVGLPKDKALELIGDDPGIDIAAVNSPSAVTLSGAVERLDLLAEKLTEEGVFARRLRVEVPYHSRLMEPIEAELRSVLADLAPRTPTVPLYSTVTGMRVSEADWDASYWWSNVRQPVRFFDAVGALVGAGHRIFLEVGPHPVLSGNIREALLGADAQGTTVPTLDREESDADSLRRTLIGLHAAGVLDRDLLFPPGRPATPHLPLPRYPWQRTRLHSALPLFEQARLGTPGGYAMLGDPDVEGRPEWLLQVGTELLPWLSDHVVNGIKIMPGAAYLDAALSATTSRIGSEQVALEGVRFVAPLIMGAPDVPLVALSIEEASGRFLIRSRSATGTAWTVHASGRTLTGSHEQTTVAVPEIEVGIDVDPAMFYTGLAAAGLQYGPSFRRVTSVRVGRDVVVATVDGAIAADSGHLAHPAVVDAAMQCAAMLFADERIDEGVMVPVGVGAVRLLAALPETVTVVARRDPNARLRADVDLLDADHKLVVRLSGLLIGALRPGDDPLHRMADFYYTETFEERDPIDPAALTEAGSVSTVVVRLGETDRADRLVAALPDSRLHVVDSTGPELESELVEQLRAARDEPARRLHICVVAGAVADDVADLWTLKRIAVAIAGFVEPPSENGTPQTIFGDGLVHCTLVTESAFTLPGSPVPPETGQAALAGARRVLLNEQTALRWRLVDIEPTTPIADLVAELAVPGAFSLDNSDEVLLRDGKRWATVITKPLPERLEALETSAPLTDPDANFELDMPRTRLLSALAWRECPRVAPGPGEIEIRMQVIGLNYKDPLKVIGLLGERELAPTYFGTVPGMEGVGTVVRIGPGLEGVSEGDLVGVAAKGMMRRFAVVDRQLAVVLPEGTDPGHCTSIIAFGTAEYALLDLARLEPGETVLVHGAAGGVGTAAIQVAKARGATVIGTAGTPERRAHVLAMGGDYAVNSRSLNFVDEVAAITGGAGADVIVSSAPGEILRQNFNAAAEFGRIVEVGKADIYTGGLLELANFDKNLSYFSMDLDRLVKVKPQRLAALLQRVFDKVTEGTYRPLPYHMFDTAEVSKAFEETLRSSRPARIALRMDAPEPPVRPYLPDVEISDTATYLITGGFGGFGLAIGRWLTLRGARRLVLAGRRGVTTEEARRQLEAWRAIGIEIVEELLDVTDSGAVADAVARIHTADRPLRGVFHAAGAVADNNLAKMELGQLEQVYLPKVLGAQIVHRAVAEAGIDLDMFVLCSSGGSMYGIYGQYSYCAANVAVESLALRWSAAGERALCVGWGHLSGAGGMAANETSEKYLDLVGFGPIDMGDATAYLEQTLRLGATRVAVIPTDWAKLTGTFPQLARTGRTAALARASAKDTSELARLREELAAMEESKRGPHIARLMAGELAVVMGVDVDTIDMTIPVPELGLDSLMAVELGARVTKTLGIDLMSLQMGRSFSLEQAGPKVAELILAHEPGGAQPDPAALAAAVDGAVANGSRPAPESNGHDAPAGAVAEMAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY56</accession>
    <name>A0A231GY56_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-[acyl-carrier-protein] desaturase DesA1</fullName>
            <ecNumber evidence="8">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">desA1_6</name>
        <name evidence="8" type="ORF">B7C42_06394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782551.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41502">
        <property type="protein sequence ID" value="OXR41502"/>
        <property type="gene ID" value="B7C42_06394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="36718" checksum="62AB80E261D69A52" modified="2017-10-25" version="1">MPKDLTQLQLLIELEPVVASQLDRHLATAKEWHPHDYVPWDEGRNFAALGGVDWDPEQSRLSEVAKVAMITNLLTEDNLPSYHRTISEHFSRDGAWGTWVGRWTAEENRHAIAMRDYLVVTRGVDPVALEQDRMVHMTRGVHAPEYFHGMLHQVVYVTFQELATRISHRSTGRVCNDPIADHMLARIAADENLHMIFYRSLAAAAFDLAPDQAMESVTTIAKNFAMPGTGMPNWRRNGVLMVKHGIYDLRQHLDEVLNPVLRHWNVFGRTDFTERGERARQELADYLDKLGRDVVRFEEQRARILAREAAKAETRDPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ03</accession>
    <name>A0A231GZ03_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">betI_24</name>
        <name evidence="6" type="ORF">B7C42_06185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41843">
        <property type="protein sequence ID" value="OXR41843"/>
        <property type="gene ID" value="B7C42_06185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22713" checksum="249C0260C3C0E5B5" modified="2017-10-25" version="1">MPKIVDRNRRRDEVAAALWRLAYREGWNAVSLRRVAAEAGLSLGSLQHYFAGMDDLLDYSVRGVVDMLDERLVEQLTTLADPCDAESTVRDVLRSMIPGAVPDPAAEQHPDDTWRIQMMAWLAVVNRAARNPEMSSRLSAGSDRLAEAIAATLPAPRHPREDALSTARGLLSLVEGLLLQLARGDIDPARASSVVTRFVALAFDASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ48</accession>
    <name>A0A231GZ48_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_05873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41889">
        <property type="protein sequence ID" value="OXR41889"/>
        <property type="gene ID" value="B7C42_05873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="22260" checksum="276096CD57287403" modified="2017-10-25" version="1">MLTVTGRGTDAERPADTRSAILAAAESCFARLGIAGTTMEDVAKAASSSRATVYRYFADRDALVTESVVRRARANMDSARAFIARHPTIEDSIVEGICEDVRRGRRDPMVHQLVSPAEMVLAARLLTESGRAVELTYELWEPVLARAQAAGALRADLDIRLLCEWISELEIYYISRGSTADAEDLDHIRARLRTFLLPALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ74</accession>
    <name>A0A231GZ74_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41914">
        <property type="protein sequence ID" value="OXR41914"/>
        <property type="gene ID" value="B7C42_05898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7373" checksum="42AE4DBC032782B4" modified="2017-10-25" version="1">MRRLRSRFTDVWGGHESEMQPYPVQRMITIPIRRAAAWNSVAGHMNLAACEAVVLHNDLPSAGASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ81</accession>
    <name>A0A231GZ81_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780741.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41831">
        <property type="protein sequence ID" value="OXR41831"/>
        <property type="gene ID" value="B7C42_06173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="33768" checksum="4FD49679DF46E942" modified="2017-10-25" version="1">MSTLDTSTLLAQLRALLTLTNTEIQVAETRIAQARTEAVRRELSENADKGRARAEAIEAAIRDLGSVPEVVGPFLGRAVAAIKAMAEQAQPFDEALLGDLALEHQLLDRSRYIKALATAAGQREIVTLADRLITAHSATVEWLTTVLAEDALGGPAALRRTVLQAATGTAVKLFNLPVTWSARGLDRALDTVRTTPPALGELLARGAHAGDVAVKTLSASRDAALETAEQVTRHEGAGAAADALHSIRATTGVLEPGELPVRDYDELNVSQAVAAVKDLTEPADIRAIVAYEEAHKKRHGVVSAAQTRLAAIAQEVTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ92</accession>
    <name>A0A231GZ92_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41927">
        <property type="protein sequence ID" value="OXR41927"/>
        <property type="gene ID" value="B7C42_05911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="232"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="549"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="608" mass="66181" checksum="8D2EA8040DC7C25B" modified="2017-10-25" version="1">MHDPDPPFRPIHRVDGYLSLEDYGLIGDGATAALVGVDGSIPWLCIPRFDAAPLFCGLLDHARGGSFTIAPAELREGRQRYRPDTGVLETELRCATGVVRVTDAMALRSGADLGEDAAADRAELVRSALVIEGRVRLAVEVSPRGGAEVRPLLSGIEIRSASQPRLRMHLRSTRPMSGLQTVFDLAQGEHVDLALSWGRFHRHHRFDAGAMLRDTANAWRSWLDGCDYAGPQQNLVRRAAITLKMCDHWASGSVIAAPTSSLPAPIGGVRNWDYRYVWIRDAAYAVFALRRIGFRGEADAFLGWVLDAVERGERPRIMYDLDGDPVPDEIVDAGLEGYRRSAPVRWGNGAADQRQHDLYGEILDCADQWLRAGGDLQPVLWAGLAGLADMAGRAWAQPDQGIWEVRSEGRAFTYSAGLCQVALDRAASIGERFRLPGPVGTWRSTAAHIRESILESAWNERAQTLSAHLDGGSALDASLLALPLRHVVPADHPRMVATTAAIADRLDAGGGLLYRYLHDESPDGLPGDEGAFVLCSFWLIDNLTMQGRIEEAAQRYESLCARASTLGLFSEQIDPSTGAFTGNFPQAFSHIGVIASGVNLARAEEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZF4</accession>
    <name>A0A231GZF4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YybR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yybR_2</name>
        <name evidence="2" type="ORF">B7C42_05936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779111.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41952">
        <property type="protein sequence ID" value="OXR41952"/>
        <property type="gene ID" value="B7C42_05936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="13725" checksum="BA7B77EEDC14DBEC" modified="2017-10-25" version="1">MTPVTPPPVADPCPISPVVDLFFGRWSTQVLWVLIHDGRMRFNEVQQRIPGVTPKVLTQRLRQLERDGLVQRTYHPEVPPRVEYAATALAATLTPLFDGLARWSNEHLAQVLAARAAYDAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZJ6</accession>
    <name>A0A231GZJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional ligase/repressor BirA</fullName>
            <ecNumber evidence="5">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">birA_4</name>
        <name evidence="5" type="ORF">B7C42_06012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42028">
        <property type="protein sequence ID" value="OXR42028"/>
        <property type="gene ID" value="B7C42_06012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="35936" checksum="9BF06F5C8A0C6DA7" modified="2017-10-25" version="1">MTDTTQRLLTLLSLLQTPREWSGSELSQRLGVSPRTVRRDIDRLRELDYPVQATMGVYGGYRLAAGTAMPPLLLDDHEAVSTAIGLRTVAAHALPGADEAAVRALAKLEQVLPTRLRARVRSVSAATETLAAESDSPVDTAVLTVLAAAIGGREQLRFGYVSNSGARTRRLVDPHRLVAAGQRWYLVAFDRERDDWRIFRIDRIESPQPIGLRTEARELPAEDAATYVRDSLYSMAPVYRAEVTVFAAAAAVRATASALGEIEEVDEHTCRLRTEADTVQWLVVRLLRLGHDFRVDSPPELADHVRELGARLQRAAPAHPGAKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZK2</accession>
    <name>A0A231GZK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator YxaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yxaF</name>
        <name evidence="5" type="ORF">B7C42_06027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42043">
        <property type="protein sequence ID" value="OXR42043"/>
        <property type="gene ID" value="B7C42_06027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="21644" checksum="C8E58FB9637BD642" modified="2017-10-25" version="1">MSETVSTPTAERIVTATAELMRRQGYGATSVKQITAAARAPIGSLYHHFPQGKQQIAAAALRTSGAAYIQLLPLLMDPYPDLRVAVVAAFTAAAEQIEQSGWMNMCPVGTVAGEIADSEPALREVTAEVMQSWIDQGSAYFRARGLPAPAAHTFVIAILGALEGAFILSRTLRSTGPIESAGLAMAAYLDTLTETRFPATMSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZQ7</accession>
    <name>A0A231GZQ7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42001">
        <property type="protein sequence ID" value="OXR42001"/>
        <property type="gene ID" value="B7C42_05985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7365" checksum="C7E791E4AC07B9D2" modified="2017-10-25" version="1">MSVDLSTAKWFKSSRSHATGDCVEVAHLTTGAVGVRDSKNPTGPALIFTPAEWDAFTTGLQDGKFQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H013</accession>
    <name>A0A231H013_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42152">
        <property type="protein sequence ID" value="OXR42152"/>
        <property type="gene ID" value="B7C42_05751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12150" checksum="9856F7854EBD0FC6" modified="2017-10-25" version="1">MDAALPGHDPFVVQTLGPGDLLGWSWLVPPYRWHFGAVTTEPVEAIEFDADRLADIADADPKFGYTLTLLLFEALVERLQATRARLLNLYRNPGEAATTAAPRRGESGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H055</accession>
    <name>A0A231H055_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42202">
        <property type="protein sequence ID" value="OXR42202"/>
        <property type="gene ID" value="B7C42_05801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="71" mass="7518" checksum="3BBDC5052A28479C" modified="2017-10-25" version="1">MPIALTLTGGAGIAATVAVAYVTVAATYWWEMRTSGPGSGADPAHDNDGEDRRGLRIRSRRPAAAHRQGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0I2</accession>
    <name>A0A231H0I2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiseptic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">qacA_9</name>
        <name evidence="7" type="ORF">B7C42_05541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42342">
        <property type="protein sequence ID" value="OXR42342"/>
        <property type="gene ID" value="B7C42_05541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="485" mass="49439" checksum="14FCAB1E650F298F" modified="2017-10-25" version="1">MPTPTSPTSTARTGPRLGWTLALLALAQSIYALDLNIVFVALPDIGSDLGFPGQTQQLVVSAYVVFAGGFLLLGGRAADLLGRRRMFLLALCLYGISSLAGGLAGSPVVIIVARAVQGIGGALLLPSTLALINTLFPEGPKRNRALAVWGGAGASGLTIGALLGGVLTENFGWPAVFFVNVPLTAVVALAALRVIPRDRAGAERRSFDFPGALLVTGGSTILVFALVEGPELGWASPLVVGALVLAVLLLAVFAVAESRSADPLMPFRLFRNRSLTVGMAVTFIYMATFGVLPYFLTVLMQTVHGYTALQTGLAFLVPSVAIATGTQLGERAATRFGVRATLLIGFGIGAVGTVVLAIGFDASAGYGALVPGLIVSGVGQGIVWTAMWIAAAAGTPGAEQGVANGIASTTLNIGNAIGLAIFTVIAELGTDNETATNSAAAQGERTVVVLTAVGMVFGLAIALLLRSGRPEPAVAPQEPGLVEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0V3</accession>
    <name>A0A231H0V3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036501263.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42505">
        <property type="protein sequence ID" value="OXR42505"/>
        <property type="gene ID" value="B7C42_05281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16193" checksum="F98C4C985EE6F301" modified="2017-10-25" version="1">MIQQERARSAEELAEAADLYFALGRITRLLRRSGDLGSLSPGSAAALGTLVRSGPMRLGDLAAAEHVTAPTMSRIVSGLEKYGYLERTADPADGRAQLLTVTEQAKSLVNGLTSARIQRFAAALDDIDAQQRRTLGDALAVLVARLDDDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H113</accession>
    <name>A0A231H113_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42512">
        <property type="protein sequence ID" value="OXR42512"/>
        <property type="gene ID" value="B7C42_05288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="29389" checksum="A96CC2512F99E75F" modified="2017-10-25" version="1">MWSMNMSATWAAVRRDAPDSGSGPLRQVAEEFADIEIVDRSMTLAAKIFTCVLPVIIAGSVFSHLDLATHAIDDQLGLDRATFRSAFGVVASTDPTFAAFGVVGLLMVVISGASFAKTLARIYGKLWDVPAIGLRDAWRWPVVLLVVAFSAATIGAVRELAGLRYFGLPLTLAGELLVWMIVWTLCAYLLTMGKLRGRALWMTGALTAVGLTSVRAGGRLVLPKITASAQAKFGLLGPVFTAISWLFVLSMVVVGAATIAKVLVPGPAPTEAEGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1D3</accession>
    <name>A0A231H1D3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tyrocidine synthase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tycC_4</name>
        <name evidence="9" type="ORF">B7C42_05428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42650">
        <property type="protein sequence ID" value="OXR42650"/>
        <property type="gene ID" value="B7C42_05428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012728">
        <property type="entry name" value="NRPS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02353">
        <property type="entry name" value="NRPS_term_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="955"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1206"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1232"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="632"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1398"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1421" mass="148482" checksum="73DC3333F888F8DD" modified="2017-10-25" version="1">MIVGSQSGAGATDAPPTAPSGSDTNGEPPEALTDSEALTDAEAAIGSEAATDPEAATHSEAATDSEPRTDSETAADSQTTTDSRTGTDAGPSGPTVTGTDGQSAPEARDSDSGQRTGHAPVSPLLRGAAAAQPRTLVDILAETAHAYPDADAVDDGTEVLTYQELLAAIDASVAELRAAGIRRGDRVGVRIPSGTARLYVTILAVLHAGAAYVPVDADDPEERAELVFGEAAVAAVVTAEGITATRPDDTGARPEGSATRRDDDRVAADPDASGPTVDDDAWIIFTSGSTGTPKGVAVTHRNAAAFVDAEARMFLQQEPIGPGDRVLAGLSVAFDASCEEMWLAWRHGACLVPAPRALVRSGMDLGPWLVRREISIVSTVPTLAAMWPAEALDAVRLLIFGGEAVPPELAERLAGTDDREVWNTYGPTEATVVACAAQLTGTPPVRIGLPLDGWDLAVVDPDGRPVAEGESGELVIGGVGLARYLDPAKDAEKYAPMPTLGWRRAYRSGDMVRNDPAGLIFLGRADDQVKVGGRRIELGELDAALQHLPGVTAAAAAVRTTATGTPILVGYLSTGDDGIDLPRARELLAERLPAALVPRLAVLDELPTRTSGKVDRDALPWPLPGADGEPGAGLDGTAYWLAGLWHSVLGADIDGLDSDFFDLGGGSLSAAQLVTALRERLPQITVADLYDHPRLGALAEFIDAAAPSEQAPTRHVTPTPRRAQWIQVLASVPLTTLTGLQWLTWLGVVTNIASRFGALPWMPGLSWWWALAGFVLFISPPGRMAICVAGARLLLRGVRPGSYPRGGSVHLRLWTAVRMAEAAGAENLSGAPWMVPFARALGARIGRGVDLHTLPPVTGMLELGDGCSVEPEVDLAGYWIDGDLVHIGEIRIGPGAVVGSRSTVMPGAVIGKNAVIEPGSAVFGKVKAGQSWAGSPAVKVGPAEHRWPATTPPRALHWVLAFGVTSMLLSALPVIALAAGGLLLAWWIRDETTLTGALAHAMLMLPVAALIVLAVFAAVTVVAIRVLSIGLTEGYHPVRSRVGWQAWATERLTDSARTFLFPLYASLLTPLWLRLLGADVGKGVEASTVLLLPKFTKVADGAFLADDTMIAGYELGGGWMHIGGAKVGKRAFLGNSGMTAPGRRVPKNGLVAVLSAAPEKAKAGSSWLGSPPVRLRRTAGDSDTARTFDPPLKLKLARALVETCRLVPVILSFGIGLGVLFALAWLASGPGYWLAALCSGVVLLIAGAVAGACAVAAKWLIVGRIQRVEHPLWSSFVWRNEVCDAFVETVAAPWFARAATGTAVMNIWLRGLGARIGRGVWCESYWLPEADLVSLGDGATVERGCVVQTHLFHDRIMSMDSVTLDAGATLGPHCVALPAARIGAGATVGPASLVMRGDTVPPSTRWQGNPIAPWPDTRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1R3</accession>
    <name>A0A231H1R3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42781">
        <property type="protein sequence ID" value="OXR42781"/>
        <property type="gene ID" value="B7C42_05119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18874" checksum="C1D5AF45A1764F95" modified="2017-10-25" version="1">MTEIELTDILRRLRRVEDELAIMRIIASYGPLVDAGQAEATAELWCADGEYDVEGWQMRGRDQVRAMVDSSAHRTLITAGSAHFQGPARIAVDGDEALAVFESLLVHRESEGYQVLRASVHRLELRRESDGWRIARRTARLLDGGEQARELLSTFAGRRGDRPSPDSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1S8</accession>
    <name>A0A231H1S8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42800">
        <property type="protein sequence ID" value="OXR42800"/>
        <property type="gene ID" value="B7C42_05138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="37" mass="3649" checksum="CE0B2806421BACC2" modified="2017-10-25" version="1">MGSMGDLLTALIPALGSAVAGDGLWETFLGSLGSIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1T7</accession>
    <name>A0A231H1T7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipid kinase YegS</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yegS</name>
        <name evidence="3" type="ORF">B7C42_05147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42809">
        <property type="protein sequence ID" value="OXR42809"/>
        <property type="gene ID" value="B7C42_05147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="357" mass="37771" checksum="0D00B95720C31DD8" modified="2017-10-25" version="1">MRTLLLVNPNATSTTPATRDLLAHALESRTQLIVAHTQHRGHAAELAQWATDAEMDLIVVHGGDGTVNETVNGFLPLPEPGTSALPEPGTSALPQPGASASDPVGAAESAAARRAGSWIPRLGVIPGGSANVFARSLGIEADPVAATNQLIDLLSLDGGDAHAGDRRIGLMVADGRWCAFSAGVGLDADVCEAIDRSRAAGHAATPARYLRTTVRQFFRAKRREPAITVRVPGHDPVPGVHYAFVTNTSPWTYLDSTPVRTNPGTTFERGLGVFAMRTMGVLPTLSVARQLLASDGDPKARNLFRVDDVSSVRIEADDEVGLQIDGDFIGRRNVVDFTSVPEVLEVVAPKPDSARHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1W8</accession>
    <name>A0A231H1W8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpA_8</name>
        <name evidence="2" type="ORF">B7C42_05174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42836">
        <property type="protein sequence ID" value="OXR42836"/>
        <property type="gene ID" value="B7C42_05174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="37709" checksum="C5B9C90C9477F762" modified="2017-10-25" version="1">MRTAGAGPAEVACAGRAPVDTPAESAAGTATGWNTPRMHRLPRCFAVLFAAFASIAAIVPAVASADPGGPAIVDVHPLGGRQYSVVVYSPAMNKQITVWMSHPDFAAPALYLLNAVDGGEDGGPWTNRTDVAQFFADKPVNVIVPMGGRASYYTDWKSDDPVLGRNEWTTFLTQELPPLLNSRFQMTGRNAVAGTSMSATSALDLAIGAPGLYQAVGAYSGCPLTNGPIPQAYVYSQLGVFGANAGNMWGVPGDPAWAAHDPVVNADRLRGTALYISSGNGVPGVHDTLADPSIGGNAGALANRVAVGGVMESVVDSCTGQLTGRLAAVGIPATVVHRNGTHAWVYWQDDLHDSWSVFAPALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Z4</accession>
    <name>A0A231H1Z4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uvrD1_1</name>
        <name evidence="14" type="ORF">B7C42_05203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42865">
        <property type="protein sequence ID" value="OXR42865"/>
        <property type="gene ID" value="B7C42_05203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="12">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="13">
        <location>
            <begin position="342"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="510"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1171" mass="125272" checksum="0FC30C30CA7233DB" modified="2017-10-25" version="1">MRLVRRSETAPRLREWGADVRTLFAGGSGADPGWRPWQVLGGPGTGKTALLTDLAADRIVAGADPESVLVLTHSKQAALRVRNALTRQLTALAPELGGVPGAGREPMVRTVHSYAFAILRTHAAARGNPPPRLLTGAEQDVVLREMLRGELADMSSGAEVLWPPRLHAALGTNGFAEQLRDLMLRATERDLGPEDLIELGRLHEREEWEAAGSFAQRYEQSMLLRWSVGVQAPEASAPALDAAELVGAALDVLIEDEELLAAERERIRTLLVDDAQHVDPLAAQLIRAIGSGPATTVVAGDPDQAVFSFRGADTRFVTEPDAPPERRIVLHDDHRCAPAVHDAVARIAARMPGRTEHRFDVRTGGPHLLGDPAVDGQALVRVLTTPAKEAALIADHLRRAHLTADVPWSRMAVVVRSVPLSLGPLRRALTAAGVPVLQPKPDTPLARRRGAAWMLQSLRALLVVERGRPELFSEDDALDLLLGPLGGADQISLRRLRRGVRRALIERGYPRTEPRVNGPDDAGPGCDGEPEAESSTRTGEPAPSLSDDADPAPSASGPARGSATAEESPEALAPYSELDRSSAVVLRDLITGVGDRTLLDRLTEVEVAPLVRVLRAVDRARRALRRGAGVEDALWALWTASRLEKRWVAQSERGGAGAVQADRDLDAAVGLFDAAAAYVDRLPGASVEGFVEYLEQQEINQDSAPLTEPGDAVAIVSAHAAAGREWDVVAVAGVQEGIWPNLRPRGTLLGIEELVDLIGGVADPGEQVSRAAPILAEERRLLLLACSRARHSLLVTAVESVTGDRDLVPSRFLAELDPEAEPGEPGRIPPPVDPGRALVAQALIAELRGVVCDDGADPARRDRAATQLARLAAAGVRGAHPDEWYGIADPSSELALWDDGDGPVALSPSTVELLQTCPLRWALERHGGSDGDNPHAVKGNLVHTLVQALAGRVTEEQVKAALVKAWKAVDPSSGEDGPHSWHSRLELRRTESMVDTFLAWLRNTRAELAEVGVEVPVDCVLPARDPDEVPVRIRGRVDRVERDALGRFVIVDVKTGKTPISKQAAQDHAQLATYQVAAGAGGFSAEVEGDRIKPGGARLVYVAKPSRDGATERLQTALDSDGIAQWRKAIHDAAAATRGPGFLAVRNDGCRHCQVAGSCPVQDTGRQVTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2B3</accession>
    <name>A0A231H2B3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent urate hydroxylase</fullName>
            <ecNumber evidence="3">1.14.13.113</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hpxO_5</name>
        <name evidence="3" type="ORF">B7C42_04877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.113" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42991">
        <property type="protein sequence ID" value="OXR42991"/>
        <property type="gene ID" value="B7C42_04877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102099">
        <property type="term" value="F:FAD-dependent urate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="43986" checksum="7646782765421E62" modified="2017-10-25" version="1">MSGTTVLVAGASIAGPALAHWLVRRGAEVTVVERAPELRPGGQAVDARGVTKEVIRRMGLDAAVRAARTETAGAYTVDADGAVLETFRADDDGGDGYISEIEILRGDLSRVLYDDTRDDVEYIFDDRIAELTQDTDGVDVVFASGARRRFDLVIGADGLHSALRAMVFGPREEFIRHLGRALAFYSVPNEFGIDRWLVDFQESGRSAGLRPLPDATQAMAMFSFPAADLDVDYRDVAAQKRLLRERMAGMGWLTARILEHLDDTPDFYLDQVAQVVMDRWSSGRVGLLGDAAFSSSPLSGQGTGLALVGAYLLAGELAAADWDPAVGFARYEALMRPYVEANQEIGRLHARSLEVPGPDSEPSPDFTGEWFAELIDRALNGVDLPDYAGVPDSRSTTAPTTSSAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2H4</accession>
    <name>A0A231H2H4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
            <ecNumber evidence="2">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43051">
        <property type="protein sequence ID" value="OXR43051"/>
        <property type="gene ID" value="B7C42_04937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16631" checksum="50BEF96A40B8B7EE" modified="2017-10-25" version="1">MTQHDRFEARSLADVTPEQMTRYSEGTFTDLIGLKYTEVGPDRVVGEWVVSPQLHQPAGIVNGGVYCTIIETLASVGGGVWFGDRGHVVGVNNNTDFLRAVREGSLRGVATPIHQGRSQQLWQVQITDEQDRVVARGQVRLQNLTAQGAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2J6</accession>
    <name>A0A231H2J6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777960.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43069">
        <property type="protein sequence ID" value="OXR43069"/>
        <property type="gene ID" value="B7C42_04955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="17363" checksum="C5891BE83CE72C5A" modified="2017-10-25" version="1">MSDNDEPRAVVLGLWAALARRDWDAVAASLTEDCIYLDVPTGPTLAAKGPADTVKRLRIGLAGLAEYTNHDGLLVAEGPDVIYEHSETWVWPTGERAELPFVSVHRVRDGRVSLWKDYWNFETLTSAAPSTWLADFAAADMSWIYDATAELSIRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2P3</accession>
    <name>A0A231H2P3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042363.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43119">
        <property type="protein sequence ID" value="OXR43119"/>
        <property type="gene ID" value="B7C42_05005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="27444" checksum="82EA4D352B55EAB5" modified="2017-10-25" version="1">MCLLTYYPAGAAIDTRALRFGAEANPDGHGFAIVASERIITGHGMNAHTVIATFARTRAAHPDGPALFHSRYATRGAIDLSNCHPFRLGGDVRTMLAHNGTLPKRVHPRAYDRRSDTRIAAEDYLPTQPFGPIDTAVGARGLAGWLGSSKLVILTVDPAYAHTAYLFGERAGQWVAGIWYSNRSYLPPEQRWLARRRTVCGYCLDRDLERTSRHCRTCSWCFHCHHAFPDCTCRPTPTRPAPTAAPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H308</accession>
    <name>A0A231H308_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, short-chain specific</fullName>
            <ecNumber evidence="9">1.3.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bcd_3</name>
        <name evidence="9" type="ORF">B7C42_04667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43245">
        <property type="protein sequence ID" value="OXR43245"/>
        <property type="gene ID" value="B7C42_04667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004085">
        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="145"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="246"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="43333" checksum="FD88BAFF8FB33347" modified="2017-10-25" version="1">MSALISDRIDDPQVTGAWELPEEFRLLRETVRRFMDSEVRPLEQQLPHDAAGLPREQLIALQDKARRLGLWALQTPEQFGGAGLSVLGQVVVAEEAAKCRMGAFFPALGAFGGNPPNVMFKATPEQFAKYAQPIIDGTATKAYTAISEASGGSDPARAITLKAVREGDHYVLNGTKMWTSHAENADWGVVYARTGEGRHGISCFIVEKDTPGLSFRRIGVMASFAPYELYFDDAVIPAENLIGAEGKGFALASDFLIHGRILYPAGPIGIAQSALEMACSWAKDRDVFGGKLADKQGIQWMLVDSEVELRAARLLMYQAAWNADLGKDVKVDASIAKLYGTEAAFRVVDRCIQIHGALGLADELPLERWFRDLRVKRLGEGATEVQRVVVARKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H345</accession>
    <name>A0A231H345_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">strE_2</name>
        <name evidence="2" type="ORF">B7C42_04725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43303">
        <property type="protein sequence ID" value="OXR43303"/>
        <property type="gene ID" value="B7C42_04725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="32044" checksum="F1A09A7796FEB222" modified="2017-10-25" version="1">MRVLILGAGGYLGSALVRCFVGAGHTVTGLVRNAAAAEQVKASGAEPVSGDLTDLPGTLALLDDAEVILFAAQLLLEPERQTVEALLDALAGTGKTFVFTSGTGVLSQRTDGEWSEDTFAEDDDFVASKYIGRRRDTEDLVRAAAGRGVRAMVVRPAMIWGHGKCPMIEGFYRSAARTGEVCYVGRGLNLYSNVHVDDAAQVYRLAVDKGTAGALYHAVSGETNFRTLAEAVARELGIPTRSIDLAEAVTIWDTFTALIAFSVCSRSRAPRSRMELGWTPHPDRLDILDEVSHPAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H369</accession>
    <name>A0A231H369_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative crotonobetaine/carnitine-CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">caiC_3</name>
        <name evidence="3" type="ORF">B7C42_04732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009542.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43310">
        <property type="protein sequence ID" value="OXR43310"/>
        <property type="gene ID" value="B7C42_04732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="413"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="510" mass="55085" checksum="1B658E52062CF2CC" modified="2017-10-25" version="1">MSAASTLASKVTDPASVLPAQLRSRAASEPNRLFLQEVSGARATYGETWEGVRNWAECLRDLGVRPGARVATLLPPSIDAAMIWLALGCLRAVEVPVNPELKGAFLEHVLDDAAPILCLARPEFVDHLRNARPALVVRAVERGAWQTLSAATMAFDALPMPTDIACVIYTSGSTGPAKGVMLDWAQFATMADRIPLGPDDVTYNCHPMFHVTGRSPLVSMCATGGRVVFRERFSAGAAMDDIREFGCTTATLIASLLLARPPRADDADNPLRSVFAGHNVALAAEFAQRFGVKCYDLYGSTEVGFPLVLSEPPDLAHTWCGRVREGYRARVVDENGRAVADGMPGELWIRPGNRLMIMVGYLNQPEATERALAGGWYHTGDIVIKHVDGTFEFLHRAGDTVRRLGENISATAIEAVIDEHPEVVASAVLGVPDSVAGHEVLVAAEVVESSALNEPALYEWMTSRLPKHALPKYLTLTDALPRTPTNKILKAGLLDSIELNSVWSPPGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3A8</accession>
    <name>A0A231H3A8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase 2</fullName>
            <ecNumber evidence="3">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB_7</name>
        <name evidence="3" type="ORF">B7C42_04757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43334">
        <property type="protein sequence ID" value="OXR43334"/>
        <property type="gene ID" value="B7C42_04757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="30473" checksum="3962623448CF09C0" modified="2017-10-25" version="1">MARNADELRTVPLTDVLRLDRIDRDLFRSVHRFDVERPLYGGQVMAQALLASGATVEPERVPHSLHGYFLRRGDGARSVLYRVDNDRDGRSYSARRVVALQDGEVIFSMSASFRTVAEGQERTRSGVTPVAAPEECRVLTLDPELALQVRVQDWSSPDPFFPVRFWARPSGELPQHDPLVHAAAIAYLSDFSAGLQRTVGSEVLGPSLDHALWFHRPPRWDDWLFIDYRNGVSAGLRGWYQGGVIDNGEVVASLAQEMAYYDTAPRLDGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3F6</accession>
    <name>A0A231H3F6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43395">
        <property type="protein sequence ID" value="OXR43395"/>
        <property type="gene ID" value="B7C42_04262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="21196" checksum="2CB6E9825EB9FB0B" modified="2017-10-25" version="1">MSAVSHRYPTNAHAAETPRECAVAESGRRSLRYQLVVIADNPVEVVSRAGGWLFDRAVAGWEVTVAVDSPGDIRPLTILGLGVLDLGCVLRCRRQVPIPHAFAVAGDLSALGEPAREWARRYIGSARTDVRFWGETDCGETSFAQASPTAYVPSRAARAFKAYALEAVGMRPPDCDVESFRTVVGAVAAGSGVRTLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3I0</accession>
    <name>A0A231H3I0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative manganese catalase</fullName>
            <ecNumber evidence="3">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydbD</name>
        <name evidence="3" type="ORF">B7C42_04275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43408">
        <property type="protein sequence ID" value="OXR43408"/>
        <property type="gene ID" value="B7C42_04275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="15686" checksum="6E2B4D8306F7F6F9" modified="2017-10-25" version="1">MDIATEEFSHLEIVGSMITMLLDGLNDDVKQANERCDWMPVVSRSDGREAAIHQVAADPLFFALRGGGPDVGNSAGVPWAGAYVNSNGEPSVDLRSNLAAETRAKIVYSNWRISVPAAANSRRRWTGSFPPPGPLSNSSSRRCGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M2</accession>
    <name>A0A231H3M2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779262.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43503">
        <property type="protein sequence ID" value="OXR43503"/>
        <property type="gene ID" value="B7C42_04370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="496" mass="54023" checksum="F2B673EC505BF75B" modified="2017-10-25" version="1">MTTTDTYERRSYGLWQKPRSAGLFGLRWGETVLGFVVVITALMTALVAGPKPALFIAIIGVVVMVPLVWRTGGRSGYETGLMMFHWLRGRSKGEHVYRGGRFSRIPGGVARLPGLMAPSRLYEGIDAGGYSFGMIHLPQFAQYTVVLRAWPQGHEAVDQPVIDRWVSAWGTFLASLGQTSDIVAVVPVIDTVPETGNRLLTEVSTITRPESPALAQQVMYELATELPQERVQLLPRVALTFKATTAERRKNPAEEAVEIGRRLPGICAALAEAGVRAQPMSADEVISFIRRSYDPAAQADLEVAAGEIGGHGLDWADAGPISHEERWDQFIHDGGRSVTWEMDAAPEGAVDERVLQRLLAPNPEVPRKRIAIVYRPHSAADAAEIVDDDYKNALVAQQSERGVVSASATLRVGATQQAREEQARGHGVTRFGALVTITEPLRGDLPRIEAITRDLSTQARLKIRRCYRYQAAAFAASLGCGVILPEHASIPKALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3S3</accession>
    <name>A0A231H3S3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional (P)ppGpp synthase/hydrolase RelA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">relA</name>
        <name evidence="8" type="ORF">B7C42_04361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43494">
        <property type="protein sequence ID" value="OXR43494"/>
        <property type="gene ID" value="B7C42_04361"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="479"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="745"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="821" mass="90038" checksum="ABC4E224E94D94FF" modified="2017-10-25" version="1">MTQHLEKANAGNSAAGDAAPAAAPATPPAAPAAPRPAAPKSGADRGAQPPASSPSPRNMPMKQPGTPAAVPSSASRRVRARLARRMTGQRGIAAVKPVLEPLATVHRELYPKANLQLLQRAFDVADEKHSHQFRKSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYSLDELTADFGSEVAHLVDGVTKLDKVNLGAAAEAETIRKMIIAMARDPRVLVIKVADRLHNMRTMRFLPPEKQAKKARETLEVIAPLAHRLGMATVKWELEDLAFAILHPKKYDEIVRLVADRAPSRDTYLARVRAEIVNTLAASRINAIVEGRPKHYWSIYQKMIVKGKDFDDIHDLVGIRILCDEVRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPDGKPLEVQIRTQDMHRTAEFGIAAHWRYKETKGKHSGDAAEVDDMAWMRQLLDWQREAADPAEFLESLRFDLKSPEIFVFTPKGDVITLPQESTPVDFAYAVHTEVGHRCIGARVNGRLVALERQLENGEVVEIFTSKAQNAGPSRDWQNFVVSPRAKAKIRQWFAKERREEALEAGKEQISKEVRRSGLPLQRLMSVDAMSALAHELHYADISALYAAVGENQVSAHHVVQRLMAQLGGVGDVENELAERSTPSTLPARQRTIGDAGVEIPGAPGTVAKLAKCCTPVPGDEIMGFVTRGGAVSVHRTDCTNADSLRAQQERIIEVKWAPSPSSVFLVAIQIEALDRTRLLSDVTKVLADEKVNILSASVMTSGDRVAISKFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Z5</accession>
    <name>A0A231H3Z5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43580">
        <property type="protein sequence ID" value="OXR43580"/>
        <property type="gene ID" value="B7C42_04448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="155" mass="16888" checksum="E8036101BCE9DD22" modified="2017-10-25" version="1">MTTVIDTSLTDRCERYRRVFHLPASVDDASRHIVLEIGQQFGAVTMPADVGERVLRQLTQSGLVTPVVHHPRARRWTFITGPSCSAGVSTSVAAELFRLYTTVACTGSHVVLPSAEDERTGYRIWVQTPDHLEAVVPMAAVVEAARLSAAPPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Z8</accession>
    <name>A0A231H3Z8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">metK</name>
        <name evidence="17" type="ORF">B7C42_04433</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502629.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43565">
        <property type="protein sequence ID" value="OXR43565"/>
        <property type="gene ID" value="B7C42_04433"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="128"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="252"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR43565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="43146" checksum="9F810A9241305C5A" modified="2017-10-25" version="1">MRTSGSRLFTSESVTEGHPDKICDAISDSILDALLTEDPHSRVAVETLVTTGQVHVAGEVTTEAYADIPTIVREKVLEIGYDSSAKGFDGASCGVNVAIGAQSPDIAQGVDHSHEARVGGSDDEIERQGAGDQGLMFGYATKETPELMPLPIALAHRLSRRLTEVRKSGVLPYLRPDGKTQVTIEYEGDRPVRLDTVVLSTQHAADIDLDNLLAPDIREKVVDAVLADLELPNPLDTSDIRLLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLSDRVEVQVAYAIGKAAPVGLFVETFGTEQVDPSQISKAIGEVFDLRPGAIIRDLDLLRPIYAPTAAYGHFGRTDIDLPWERTDRADKLRAAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4A2</accession>
    <name>A0A231H4A2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator Mce2R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mce2R_3</name>
        <name evidence="5" type="ORF">B7C42_04535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43667">
        <property type="protein sequence ID" value="OXR43667"/>
        <property type="gene ID" value="B7C42_04535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="24895" checksum="AB6498C70F5FBE2C" modified="2017-10-25" version="1">MAVPDAAYVRIVEEILSGRVPAGEALPSERELALAFQVNRHAIREALKRVQQAGLIRISHGGKTRVLNWRENARLEILSDIVAAGVVPPLEIVRDVAVMRRSIGADAARLCAANASDEQLERINAIAHAFPDQDAAVEEYGDADLAFWTAVIDGSGNLAYRLALNTLVATFNDLGLPIVAEWIGGEYTDRAGRIALADLIAARDGAEAYRHAEQLLTHFVARVDQTAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4B3</accession>
    <name>A0A231H4B3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_04528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43660">
        <property type="protein sequence ID" value="OXR43660"/>
        <property type="gene ID" value="B7C42_04528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="95" mass="10507" checksum="36262EEA9EB5BE9C" modified="2017-10-25" version="1">MNIRAAEQVSVYRLAFFYVWLGLIAVTCLSFWLGIGHRASSAEVVNIVVIAVACLKIRFIGLYFMDLKDAPRGLRSIFESYCIGIGSALIALSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4M4</accession>
    <name>A0A231H4M4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding proteinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43780">
        <property type="protein sequence ID" value="OXR43780"/>
        <property type="gene ID" value="B7C42_04015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="96" mass="9861" checksum="80AF1D7EC46A7B18" modified="2017-10-25" version="1">MRVCSAGGEAGGADVPEVSGAMMSGNSSASSGPVIGGGGTQFLTVAEVANLMRVSKMTVYRLVHSGELPAVRVGRSFRVHAKAVHDYLQTSYFDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4V9</accession>
    <name>A0A231H4V9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43870">
        <property type="protein sequence ID" value="OXR43870"/>
        <property type="gene ID" value="B7C42_04109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="121"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="359" mass="38343" checksum="011C6377F04BA0BC" modified="2017-10-25" version="1">MKAKLRGLGGPLTKLGIFVLVTVLATAFLALTIANYSGGGTEFKARFSDVTSLNKGDEVRIAGVRVGKVTKVAVVDRNMAEVHFQITDRDWLPASTTATIRYRNLVGQRYIALEQGAGQQGRKITKGATIPLERTKPALNLTTLFNGFRPLFQTLSAEDVNKLSYEIIQVFQGESGTITDLVRNTASLTNKIADKDAVIGEIVKNLNQVLDAVNARDGQLNDLIVNTEALVSGLNAERGTIGSAVQSLGNLASATADLLVPTRPTLQGSIAGLNQLTGTLNDRSGEVNEALTNLPIKMEKLGRAASYGSWFQFYLCGIDIVAGPGVQDAPQLNLPAQMPTVNQPVYTNPAPRCHGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Z4</accession>
    <name>A0A231H4Z4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent stearoyl-CoA 9-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">desA3_3</name>
        <name evidence="3" type="ORF">B7C42_03569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44013">
        <property type="protein sequence ID" value="OXR44013"/>
        <property type="gene ID" value="B7C42_03569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="39910" checksum="761BF801C8863D4B" modified="2017-10-25" version="1">MTTPALVPHSRPRRTGADGDYARLLRRVSDAGLMDRRPGYYVIRLSLVGVAFVAGLVAFVLVGDSWWTLMVAAFMAVTFAQVALVMHDVAHRQVFRLRRPTEILGRVVGNAGIGLGYGWWQDKHTRHHANPNHEELDPDVAPDILVWSQRQARGSRGLPRLIGRAQAFLFFPLLLLEGLNLHVAGVRALRNRAAKHRLLEGALLLGHFVVYLGALFAILPADKAFAFFAVHQALFGLYMGCIFAPNHKGMPTFTGDDRPDYLRRQVLTSRNVRGGALTDIALGGLNYQIEHHLFPSMPTPNLRRAQVIVREYCAEIGVPYHETGLVASYREALRHLHDVGVPLRAGGPRQEPIEGSTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5F4</accession>
    <name>A0A231H5F4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_14</name>
        <name evidence="9" type="ORF">B7C42_03640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44084">
        <property type="protein sequence ID" value="OXR44084"/>
        <property type="gene ID" value="B7C42_03640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="41865" checksum="8C6DAE05E29C022C" modified="2017-10-25" version="1">MRRTGFTADHDAFRGTIRKFVETEVAPVYDTWLEAGIVPREFYYKLAELGVFGIEVPEEYGGAGIESFKFQAILMEETARAGVSFGGSSVHVGLCLPYLKKLATEEQKQRWLPGFAAGEIMFAIAMTEPGTGSDLAGMRTTAKLSEDGTHYVLNGAKTFITGGVNADRVIVCARTAPPREDDRRFGISLLVVDTTSPGYTIGRKLDKLGLRSSDTAELNFTDVRVPVEDLLGEENKGFSYLGQNLPQERLSIAAGAYAQAAAAVRFAQEYTQQRNVFGKPVASFQNTKFELAACKAEVDAAEAVVDRALDALDAGELSAADAASAKLFCTEVAARVIDRCLQLHGGYGFINEYPIARLYADNRVNRIYGGTNEVMKMIIAKDMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5I6</accession>
    <name>A0A231H5I6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777606.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44263">
        <property type="protein sequence ID" value="OXR44263"/>
        <property type="gene ID" value="B7C42_03824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="46561" checksum="AD27996FE9D419B0" modified="2017-10-25" version="1">MTDPVTRAQLILLARTLHVPPERLAYLERLGARNLHELQQRMAAIVFDQHAETFRRISRLVPIIPLGISMPLVQKLVPPALTGRAAGAVGVDHPKKAAETVALLGIGYAADCAPYLDPRTVGELADIAPPEPIVQIVNEVLRRRDYITAGPFLGYASPRLIEAVERGVPDDEGLIFSASFAFSTSALTSVLRQLLNGPARRMPRMIQTVLHGSPELRLAALSIFARCDADVVADVGDIVLGVGTPAVLCNLVTTAIHGRAVRDMAVFFDTLRPAALAAMAALPIFTDPAVAAALLQGLEGCSDPPPWRGLFALLAQLDPTMRPALAAMLAQQSDATIAALPSHATEADLWPVLLDIVAAGDHSVQERIGSRWAMLPPERRAGVQWHLDERGDDPRLTTVARAVAASSVSVEEVFFRRRQLGRRRGADSWDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H601</accession>
    <name>A0A231H601_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777609.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44265">
        <property type="protein sequence ID" value="OXR44265"/>
        <property type="gene ID" value="B7C42_03826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="89"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="322" mass="33248" checksum="DD0C8289C0399DD5" modified="2017-10-25" version="1">MAIPTAFTDILSVRHPIVSAPMGGEAGGALAAAVSEGGGLGLVGGGRGDREWVERELRLVRENTTAPWGVGFLSWAIDRTVLDHALSFDPAAVLLSFGDPLPLAATVRDAGAVLIVQVTDADEARRALDAGADVLVAQGSDAGGHCAAQGIGTLSFVPTVVDLAGAVPVLAAGGIADGRAIAAALALGAAGAMVGTRFQATHEALVPADLGKALVDATGGDTEVNWTLDIARGAPWPEKYPARTLRNTFIDRWRGRDDELRTDEAALREYRDAAARNDLTAVPVWAGQAVDRITSIASATELVGVLAEETEAALRRIAVRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6I7</accession>
    <name>A0A231H6I7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroG_1</name>
        <name evidence="7" type="ORF">B7C42_03437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776131.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44643">
        <property type="protein sequence ID" value="OXR44643"/>
        <property type="gene ID" value="B7C42_03437"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="53"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="362" mass="38306" checksum="94E03401FE0CC4E5" modified="2017-10-25" version="1">MTTAADVDASHSDLDDQRTLSISPLLSPAEVRREHPIDDALADTVRAGRAATVEVLDGADDRLMVVVGPCSVHDPEAALDYARRLAAESAELSDRLHIVMRVYFEKPRTTLGWKGLINDPHLDGSFDVNTGLGLGRRLLVDITGLGLPVACEFLDPITPQYIADLVSYGAIGARTAASQVHRQLSSALSMPVGIKNGTDGDVQVAVDGVRAAGASHVFPGTDLDGRSALIRTSGNPDCHVILRGGSAGTNYDAASVAEACLRLEKAGLAQRVVVDASHGNSNKDHNKQVDVVTDIAERIAAGDRAVVGVMMESFLVAGRQDLTLGRADDLTYGQSITDACLDWETTAAQLDRLADAVARRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6V5</accession>
    <name>A0A231H6V5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gluD</name>
        <name evidence="9" type="ORF">B7C42_03368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44578">
        <property type="protein sequence ID" value="OXR44578"/>
        <property type="gene ID" value="B7C42_03368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="193"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="421" mass="44404" checksum="50BDCCB61546137D" modified="2017-10-25" version="1">MTTIHNPAEDTAPALPAVPATVPAVPTDTPVTPAIRRPEPYLRLQWTDAATGAVGYLVVHTLRGGLATGGTRMRAGCTLSEVEDLARGMAAKTATFDLPIGGAKGGIDFDPKDPRAVGVLERFCEAMRPWIDAHWVTAEDLGVPQHLIDEVFEKLGLGQSYHAAIRRAADPVATLERVRDGLNAAVEGGFLLGDVIGGYGVAHACLATAVSWGRMPAETTVAIQGVGTMGGAAAYYLHEAGMRVTTVADAAGALHRAGGLDIPALLELRDDYGEIDRSRLPADVEQLPRTAVLSAEVDILVPAAISYAITPDNSFDVRARVVVEAANAATTPEAEAMLAARGVPVLPDFVANAGAVAWAWWLLLGQVDDVPDTSFDRLRTTMHTKVARLLSAWTDDGITPRETGRRWAEDPAPTTGAVVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7D0</accession>
    <name>A0A231H7D0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44657">
        <property type="protein sequence ID" value="OXR44657"/>
        <property type="gene ID" value="B7C42_03451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8087" checksum="E52EC6FBC37318B6" modified="2017-10-25" version="1">MPDSSSPRAPRGSSDVLLRVAVGLFAVGVLAIVAIFLTPILTDGDPPLWLYLVAMAATPLGLLLAIAFALWSGRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Q9</accession>
    <name>A0A231H7Q9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44889">
        <property type="protein sequence ID" value="OXR44889"/>
        <property type="gene ID" value="B7C42_02844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556652" evidence="1">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8685" checksum="B4BB263FD21F536A" modified="2017-10-25" version="1">MMGTVHRTAARVLMVTAIAVAPILPAAPALAEQPAGAPAVQVAHDTGWYGNPCNWGFNWLYPQCWFGWGNYDGFHGWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H826</accession>
    <name>A0A231H826_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-protein kinase RsbW</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsbW_2</name>
        <name evidence="3" type="ORF">B7C42_02955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44998">
        <property type="protein sequence ID" value="OXR44998"/>
        <property type="gene ID" value="B7C42_02955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="176" mass="18903" checksum="E26FC9211C35A8D3" modified="2017-10-25" version="1">MEIIGCDRNEDMSGFPDPPGDPAPGPAVREPHPLRVAPFEANFLSQADRIAEVRHDLRAWLERGGIGSEQIYDLLLAVDEACTNAVEHGYREGAGMVGLRAEISGSDLYLTIVDHGSWEPRAEVPDPVRGRGLAIMRALVRDVEITTGADGTRVVMRTEIVSAPTGSESTAGSDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8H7</accession>
    <name>A0A231H8H7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_9</name>
        <name evidence="9" type="ORF">B7C42_03102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45145">
        <property type="protein sequence ID" value="OXR45145"/>
        <property type="gene ID" value="B7C42_03102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="133"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="243"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="391" mass="42370" checksum="574B6B9B5CE4727C" modified="2017-10-25" version="1">MIAKGAGPSTAAESPWMVEELAAVGELARTFFVKEVVPHEPRFAKQGFPDRELFRRAGELGLLCMSIPAEYGGGGGTCAHDAVLFIEQTKASVGCMHLGVHSSIVPNYLLAYASEEQKQRWLPKLAGGEWVGAIAMTEPGAGSDLQNITTRAVREGDEYVISGAKTFISNGHNCDLVIIAAKTDPSARAAGVSLLVAEVGDDTPGFTRGKIIEKLGQKSQDTTELFFDGLRVPAANLLGTGEGQGFAQLMSQLAHERLLCAVTAVAATEHAVQLCVDYTKERKAFGKPLFDLQNTRFELAECATTARIGRGFVDELIVRHLRGDLDPVTAAMAKYWTTEQQCSVIDRCLQLFGGYGYTLEYQIGRMYADARIQRIYAGANEIMKELIARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8T3</accession>
    <name>A0A231H8T3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cholesterol oxidase</fullName>
            <ecNumber evidence="4">1.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">choD_2</name>
        <name evidence="4" type="ORF">B7C42_03054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45097">
        <property type="protein sequence ID" value="OXR45097"/>
        <property type="gene ID" value="B7C42_03054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="3">
        <location>
            <begin position="460"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="566" mass="61704" checksum="3EC9B2DA2B6BAE98" modified="2017-10-25" version="1">MGFDYDVVVIGSGFGGSVSALRLTEKGYRVGVLEAGRRFADDEFAKNSWRARQFLWAPRLGCFGIQRLTLLKDTFIMSGAGVGGGSLVYANTLYEPPAKFFADPQWAHITDWDAELAPHYDQAKRMLGVTTNPATTASDRVLREVAEELGVGASFRHTPVGVLFGGNGTRAGQEVPDPYFGGVGPSRRTCTHCGECMTGCRHNAKNTLVKNYLYLAEKAGAAVHPHTTVVDVVPLPSGGYRVDTVRTGRWIRKARRSFTAEQVIFAAAALGTQRLLHRLRDRGSLPHISARLGYLSRTNSEELLSIRSRRADTDFTKGVAITSSIHPDADTHIEPVRYGKGSNVLSLMTTVMYDEDGSTSRTRLWLRENWRRRRDLAKVHNPRRWSERMIGLLVMQSVDNSLTTYTERGLFGRRMTTKQGEGQPNPTSIPAGHEVAHRVADKIDGIATAGFTSLFGIPMTGHFIGGCVIGDSPQTGVVDPYQRMYGHPGLHIVDGSAISANLGVNPSLTITAQAERALALWPNKGEPDRRPALGAPYRRLAPVSPTAPVVPADAPGALRLPIVDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8V8</accession>
    <name>A0A231H8V8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">B7C42_02578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025347279.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45453">
        <property type="protein sequence ID" value="OXR45453"/>
        <property type="gene ID" value="B7C42_02578"/>
    </dbReference>
    <dbReference type="GeneID" id="66719005"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="37" mass="4380" checksum="348CB04FBBFEF0C8" modified="2017-10-25" version="1">MKVQPSVKKICEKCKVIRRNGRVMVICDNLRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Z6</accession>
    <name>A0A231H8Z6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">betI_6</name>
        <name evidence="6" type="ORF">B7C42_02453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45328">
        <property type="protein sequence ID" value="OXR45328"/>
        <property type="gene ID" value="B7C42_02453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="28254" checksum="C203F481B6C1F90D" modified="2017-10-25" version="1">MESGNSIHQKPVFWQESMPELRPCHNRTVTAQRTYGGISAAERRAGRRAALLDAALEIIGTQGVDKLTVAGLCAQAGLNERYYYEQFTGRDAVLTALFDGIAEELASAIVQALQEVAGGSAADTPSAARENAANPSARRMRPETRTMAHAAVAAGIHVLTDDPRKAQVALAVSASTPELRSRTLQTIASFANLVAARGIDFYALSTPTPDPAIGFRATYLVGGLVQTLTSWLQGDIDMTREQLIDETTDVFVLLGEDLAQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H925</accession>
    <name>A0A231H925_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inner membrane metabolite transport protein YhjE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yhjE_1</name>
        <name evidence="8" type="ORF">B7C42_02483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45358">
        <property type="protein sequence ID" value="OXR45358"/>
        <property type="gene ID" value="B7C42_02483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="32"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="449" mass="47560" checksum="681BF68E07287A2D" modified="2017-10-25" version="1">MSVLESAPATTRVAGQHEERPDHLGAAETRTAVAASLIGTTVEWYDFFLYSTAAGIVFNKLFFPDTSAFIGTMLSFATFAVGFVMRPVGGLVFGHIGDRIGRKRTLALTMAIMGGSTALMGVLPTSAAIGIAAPILLLALRILQGFALGGEWAGAVLLAVEHSPRKKVGRFGSYPQIGLALGLALGTGVFALLRSVLSEQAFLDYGWRIAFGASVVLVVIGLVVRLKIDETPAFQEIDRLNRISKVPVVELFRNARTRRNTVLGLLSRWGEGAAFNTWGVFAISFATGHLGFEQVPVLLAVTIAAVVMAALIPVSGNLTDRFGPRRVYIAGIAAYGVLVYPVFALFEVGNIVVFTVAIIAVFGVAHALFYGAQGTLYAGLYPAEVRYTGLSFVYQVSGIYASGITPMIVTALIAAGGRTPWLACGYLVATAVISVVATLFISEDDRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9F6</accession>
    <name>A0A231H9F6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydroanticapsin 7-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.385</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bacC_2</name>
        <name evidence="1" type="ORF">B7C42_01876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.385" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783962.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45584">
        <property type="protein sequence ID" value="OXR45584"/>
        <property type="gene ID" value="B7C42_01876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="26803" checksum="EF34503A314F3BF2" modified="2017-10-25" version="1">MSTATAAPIPVRSPLTSDLSDSTVVVVGGSSGIGLAAGTLLRSIGARVVLVGRDSERLKAAVDRVRGINPIDSDDAVQGVAGDGGDEEVLVEAFDRAGHVDHLFVTVGGTSGMGPLTEVSLDVLRATFETRVPAAYAAARVASTRLPAGGSLTFSSGTVVVRPFPGASAGLSAAGAVEALTRSVGVELAAARIRVNTVRFGRIDTPLLRSNPGMESDEAIAAAGSTWPLGRFGTAEEAASAALFLMANNYITGQIINVDGGETMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9F9</accession>
    <name>A0A231H9F9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpmD</name>
        <name evidence="8" type="ORF">B7C42_02620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513404.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45495">
        <property type="protein sequence ID" value="OXR45495"/>
        <property type="gene ID" value="B7C42_02620"/>
    </dbReference>
    <dbReference type="GeneID" id="66718964"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="61" mass="6855" checksum="71ECD163541D4E90" modified="2017-10-25" version="1">MAQLKVTQIKSTIGAKKNQRESLRTLGLRGIRQTVVREDNAQNRGLINVVRHLVSVEEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA85</accession>
    <name>A0A231HA85_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease VapC5</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">vapC5</name>
        <name evidence="1" type="ORF">B7C42_01948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45656">
        <property type="protein sequence ID" value="OXR45656"/>
        <property type="gene ID" value="B7C42_01948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15154" checksum="90F51CE8A8FB456F" modified="2017-10-25" version="1">MTEPDNSFRHQAGLLDTCVCIDLPLIEEAALPIELRISTVTLAELGLGTAMAATAEELAIRTERLLEFEHAFDALPFSSTAARRFTSMSKLVVAAKRNPKPRRMDLMIAAIASANDLPLFTRNPDDFKGLEALLTVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAL9</accession>
    <name>A0A231HAL9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain type dehydrogenase/reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778148.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45898">
        <property type="protein sequence ID" value="OXR45898"/>
        <property type="gene ID" value="B7C42_02190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="28699" checksum="882B1C07136B5BCB" modified="2017-10-25" version="1">MTGRLTDRVAFVTGAARGQGRAHAVRMAREGADIIAVDIAGPLPPCVPYDSATGADLAETVRLVEATGRRIRAAAVDTRDLDGLRKTVDEGVGDFGRLDVVVANAGIAVPEPWDAITPQSFRDVIDINVTGTWNTVAVAAPHLVEGGRGGSIVLISSAAGIKMQPFMVHYTASKHAVAGMARALAAELGRHAIRVNSVHPGPVNSAMGTGEMVTRLGAAMETNPQLAHMMTPFLPTWVLEPEDIADTVCWLASDESRYLTAAAIPVDQGSTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAS4</accession>
    <name>A0A231HAS4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trypsin</fullName>
            <ecNumber evidence="3">3.4.21.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45929">
        <property type="protein sequence ID" value="OXR45929"/>
        <property type="gene ID" value="B7C42_02222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013053792" evidence="1">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="24825" checksum="01FAB7A6002DA126" modified="2017-10-25" version="1">MKISPRRVVGAVAAAFACALVPPTGAHAVVGGAPVDAADYPWLAAIGTPVYATRLGGQFCAGALIAPDRVLTAAHCGALARTLPGTTVTFGRTDVAGHGGVTIGIADVRIDPDFRVSLFGTDLSYHHNVAVLVLSAPVALPTVAVGAPHGDTATVVGWGATSEDDQSNSVLRAATVPLVPDAACAVAYAAEFDPAEAVCAGSPTADTAEFDSGGPLLVDGKVAGITSWGKGSAEPGFPGVYARVPALDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB73</accession>
    <name>A0A231HB73_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_2</name>
        <name evidence="4" type="ORF">B7C42_01158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46193">
        <property type="protein sequence ID" value="OXR46193"/>
        <property type="gene ID" value="B7C42_01158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="447" mass="49496" checksum="A7DFED8A38B0F9B1" modified="2017-10-25" version="1">MSRTLHLNAFLMSTGHHEASWRLPESNPLAHVDIEHYICLAQTAERGLFDSIFFADSPVLQGDPGRRPVGKLEPTILLTAIALRTSRIGLIATASTSYNDPYNLARRFASVDWVSGGRVGWNIVTTAGADAARNFGLDDVPDHRLRYEKAAEFVDVATKLWDSWDDDAFIGDKELGIHSDPDKVREINHIGEFFRVAGPLNVPRSPQGYPVLVQAGSSEDGKGFAARYAEAVFTAQQTLEDGKQFYADLKERARRLGRDPGTVKILPGIVPVIGDTEAHARELDDELTRLIQPEYQRRTLAERFKLPVEALDLDSELPADLPTEDEIQGAKSRFTLIVNLARRERLTVRQLIARLGGGRGHRTFAGTAEQVADTIQEWFTDGAADGFNVMPAALPSGLERFVDEVVPILQERGLFRTEYEATTLRGHYGLARPENRFSVAADAAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB76</accession>
    <name>A0A231HB76_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator SlyA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">slyA_1</name>
        <name evidence="2" type="ORF">B7C42_01062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46098">
        <property type="protein sequence ID" value="OXR46098"/>
        <property type="gene ID" value="B7C42_01062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="155" mass="16477" checksum="0736BC2140B5C8E8" modified="2017-10-25" version="1">MSRGDAGLFSAAAITTFKLNGQFLTIAEELAKPAEITAAWWQVLGAVLHEPLPVSGIAREMGITRQSVQRIADLLVGKGLAEYRPNPSHRRAKLVAITDAGSAAIRRITPKHAVMAKQLARQLGPQRFAEVVDALGDLSAALEALESGDRGTSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA0</accession>
    <name>A0A231HBA0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Na(+)/H(+) antiporter subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mrpA</name>
        <name evidence="13" type="ORF">B7C42_00999</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781331.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46036">
        <property type="protein sequence ID" value="OXR46036"/>
        <property type="gene ID" value="B7C42_00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="803"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="826"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="10">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="121"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="12">
        <location>
            <begin position="600"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="11">
        <location>
            <begin position="796"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR46036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="946" mass="99700" checksum="02A8C9F66751D773" modified="2017-10-25" version="1">MLAILLAHASAALLAPPAVRVWGRRGFYPIALAPLAGLVWVIANWNSEAEVRITWAPEIHMNWDLRLDSLASIMSVLVLGVGALVLVYCAEYFDDDDRARLGIFAGYLVAFAGAMFGLVVSDNMLVLFTFWELTTVLSFLLVGHHAEQSTGRRAALQALLVTAAGGLAMLVGLVLLAQRCDSYLLSDVVARADPHDWSTNVAVVLILIGALSKSAIVPLHFWLPGAMIAPTPVSAYLHAAAMVKAGIYLVARLAPGLSEAPVWHPIVLTLGILSMLLAGLRSLQVYDLKLVLAFGTVSQLGFMLVLVGTGTPEAALAGAALLVAHALFKGCLFMVVGIVDHSAGTRDLRRLSGVGRRAPVLCAVATVAALSMAAIPPLFGFVGKESAFAAELDAGNLSAPVRIAVALGIVLGSMFTVGYSARMVWGAFGTKRAAEGVPEPERPWHRPSALFVAPPAVLAAASLAAGLASPWMDELLSPYARTLGPLEAHLALWHGWGTPLTLTLIAIACGLVLFEIRDRIGESVNPRLGNADRVYDAVLRAMDQLSLRMTGATQRGSLPLNQGLILTTVVVLPLAVLFVGARSRISVRAWDSSLQLVIALVMAAMALGATIMRNRLASVLLVGVTGYGCGVIFALHGAPDLALTQFLVETLTLVIFVLVLRKFSAEIEPSRTAALKVRRALLSVAVGAAVVTVAAFATAARGTEPIWHRIPSAAYSFGGGKNAVNVLLVDIRAWDTLGEISVLVVAATGVASLMFRSRRFGTLPRVSEAPGYTPDPERAYWLRASPLVAPRDRSMVMAMTTRMLFPTIMVLSAYFFFAGHNAPGGGFAGGLTAGLALVLRYLAGGRYELAEALPVDAGHVLGAGLVLSAGTATGSLLLGAPPLSSAIIEVTLPVLGHIKFVTAMLFDLGVYLIVVGLVLDVLRSLGARLDIEFLDGRTSSTKGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBC5</accession>
    <name>A0A231HBC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="7">2.7.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiD</name>
        <name evidence="7" type="ORF">B7C42_01029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781364.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46066">
        <property type="protein sequence ID" value="OXR46066"/>
        <property type="gene ID" value="B7C42_01029"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="28843" checksum="35880BDB231E1963" modified="2017-10-25" version="1">MKLLPLPEPGTTPVRVLTIAGTDSGGGAGIQADSRTMALLGVHACVAVAAVTVQNSVGVSGFHEIPPQTVADQVRVVTGDIGVAAAKTGMLASTAIIEAVARVCDEVGIGRDGTVPLVVDPVAASMHGDPLLHTEALDALRSVLIPRATLVTPNLDEVRLLTGIAVTDDRSARKAAEALIALGPRWAVVKGGHLRSSEFSTDLLFDGDRFHELTAPRITTGNDHGGGDTLAAASACALAHGYPVPEAVAFAKEWTTRCLAASYDLGAGHGPVSPLWRLHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBY0</accession>
    <name>A0A231HBY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD-dependent oxidoreductase LodB</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lodB</name>
        <name evidence="2" type="ORF">B7C42_01172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781499.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46207">
        <property type="protein sequence ID" value="OXR46207"/>
        <property type="gene ID" value="B7C42_01172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="498" mass="54863" checksum="F18FC2F0FD885A52" modified="2017-10-25" version="1">MGNNEIPRVLVVGGGPAGSTAAALLARSGVQVTLLERDTFPRYHIGESLLASCLSTLRISGAYDKVAAHGFQIKRGGYFQWQNDTWLLDWSKLVDAEAWSWQVDRAAFDDLLLRNAADQGAQVIEQATVKNILFDGERPTAAEWVRAGDDTVHTAEFDFLVDATGRDGLLAKHFGMRRQHPAFRNVAVWSYWKGAHLHPDSPEGAINVVSTPEGGWFWNIPLADGRTSVGYVVSARLAAEKLRAHDSRQSYYLETIRESKPMCEMLEGAEQIADVRAEQDYSYVADRFCGPGYVLVGDAACFLDPLLSTGVHLATYSGLVSAAAIATTLRGEMSEADALAYYEYTYRRGYTRFLSLVSRMYEHYIGSEEYFAHAHKLTDVHDGDSPEQSFTRIMAGLTDVGETTGDQDRTGTEVIVSEAERLHTAPDTDGVNIKYMGGLDMSPVWDHWRDPLSDTTMGEIRITTEPVFGLTSRPRSDAEREAVALPVQPPRKGAGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBZ5</accession>
    <name>A0A231HBZ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase FadE10</fullName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_01334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46368">
        <property type="protein sequence ID" value="OXR46368"/>
        <property type="gene ID" value="B7C42_01334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="60"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="169"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="279"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="651" mass="70699" checksum="10BADCE8852F919A" modified="2017-10-25" version="1">MATAAKVHATEEQARALVEESRESTWAKPSFAKQMFLGRFRLDLIHPYPQPAPDDAARTEAYLERLRAFCETLDGSVIEAESKIPDDYVRGLAELGCFGLKIPPEYGGQGLSQVGYNRALMMVGSVHASLGVLLSAHQSIGVPEPLKLAGTEEQKREFLPRCARGAVSAFLLTEPDVGSDPARMASTATPTADGEAYELDGVKLWTTNGVVAELLVVMARVPKGPGHRGGISAFVVEADTPGITVERRNAFMGLHGIENGVTRMHKVRVPARNLIGREGDGLKIALTTLNAGRLAIPALCTAAAKWSLKISRGWSAARVQWGRPVGEHAAVASKISFVAATAFALEAVLELSGTMCDEARNDIRIEAALAKLWASEMSCRIADELVQIRGGRGYETAASLRHRGERAVPAEQLVRDLRINRIFEGSSEIMRLLIAREMADAHMAAAGALVDRHAALKDQATAAVGASGFYAKWFPQLAVGRGTLPAGYTEFGPLATHLRFVERMSRKQARELMYAMARWQAKLEYRQGFLGRLVDIGAELFAMSAACVRAQAMRAEDSRDAAAATELADTFCRQSRLRVEAAFDALWDNTDDADTALTRQVLEGRYEWLESGVLDPSEGTGPWIAEWEFGPSTEHNLLTPFLPSTRTAADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCR1</accession>
    <name>A0A231HCR1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ketoacyl reductase</fullName>
            <ecNumber evidence="2">1.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">actIII_1</name>
        <name evidence="2" type="ORF">B7C42_01590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775222.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46619">
        <property type="protein sequence ID" value="OXR46619"/>
        <property type="gene ID" value="B7C42_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="24549" checksum="759F95195D03ECF5" modified="2017-10-25" version="1">MSERTIALVTGANKGIGYEIAAGLGALGWRIGVGARDELRRDTAVEKLRAAGIDAFGVPLDVTDDASVAAAAELIADHAGGLDVLVNNAAITGGLPQTPTTVDPATVREAVETNVIGVIRVTNAMLPMLRASAAPRIVNMSSSVGSLTLQTTPGTDTGPISAAYAASKTFLNAVTIQYVKELADTDILINAGCPGFTATDLNGFRGVRTPQQGAAIAIHLATLPDDGPTGGFFSDAGPVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCW7</accession>
    <name>A0A231HCW7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46642">
        <property type="protein sequence ID" value="OXR46642"/>
        <property type="gene ID" value="B7C42_01616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="119" mass="13054" checksum="EBAE67038E7E234F" modified="2017-10-25" version="1">MPDNDSRDQIVALILDTREQGMSPAEAADHLLAAGVRPRRRRIAEPEATQPDPAGYLVGCQHDGAPLLEFEAVHVDPFGDRARAYATRGEAQAFADKCGRYNPRTVFKVYALQEMSADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDD1</accession>
    <name>A0A231HDD1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46904">
        <property type="protein sequence ID" value="OXR46904"/>
        <property type="gene ID" value="B7C42_00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="92" mass="9516" checksum="2A3BD2553A810A74" modified="2017-10-25" version="1">MAVASEWSRPAGAVNEMTRGAARAPENATTAPIARTPISPAHARSRIGRVSPAPCQRATDICVAEPHGITSAEQKIQNGSTRAAIPSASVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE81</accession>
    <name>A0A231HE81_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaJ2</name>
        <name evidence="6" type="synonym">dnaJ</name>
        <name evidence="10" type="ORF">B7C42_00405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036499695.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47283">
        <property type="protein sequence ID" value="OXR47283"/>
        <property type="gene ID" value="B7C42_00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="382" mass="40684" checksum="B1D129FD1A2A5059" modified="2017-10-25" version="1">MARDYYGILGVGRNASDQEIKRAYRKLARELHPDVNPDPDAQERFREVSTAYEVLTDSEKRRIVDMGGDPMESAGAGGGFSGAGFGGLGDVFEAFFGGMNATSSRKPRGRVQPGADSLLRTRLSLAECAVGVTKHLTVDTAVLCDLCQGSGTNGNSKPVRCETCGGAGEVQTVQRSFLGQVMTSRPCPTCRGTGETIPDPCRKCGGDGRVRARREIAAPIPAGVANGMRVRLAAQGEIGPGGGPAGDLYVEIVEQPHDTFVRDGDDLHCTIRVPMVDAALGTTVVIDTILDGPTELTIPPGTQPGEVSVLRAHGMPKLRSSSRGDLVAHLDIVIPTKLDNKQFDLLRKYQAMRNGEHTEVLSAQSEHNSGLFARLRASFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HED3</accession>
    <name>A0A231HED3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">glyQS</name>
        <name evidence="9" type="ORF">B7C42_00423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777817.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47301">
        <property type="protein sequence ID" value="OXR47301"/>
        <property type="gene ID" value="B7C42_00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="8"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="324"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="207"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="328"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="463" mass="53016" checksum="89D49C0D6CDA0EFE" modified="2017-10-25" version="1">MAPKSKIDTVANLAKRRGLVYPSGEIYGGTRSAWDYGPLGVELKENIKKQWWRAMVTSRDDVVGLDSAIILPRPVWVASGHVSVFNDPLVECLNCHKRHRQDHLQEAYAEKHKIDDPDSVSMDLIGCPDCGTVGKWTEPRDFNMMLKTYLGPIESEEGLHYLRPETAQGIFVNFANVMTTARKKPPFGIAQIGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEQWHQYWIDTRLAWYTDLGIDPENLRLYEHPKEKLSHYSTRTVDIEYRFHFQGSEWGELEGVANRTDFDLSTHSKHSGTDLSFFDQNTNERYTPYVIEPAAGLTRSLMAFLIDAYNEDEAPNAKGVMEKRTVLRLDRRLAPVKAAVLPLSRNADLSPKAKDLAAQLRRNWNVDFDDAGAIGRRYRRQDEIGTPFCITVDFDTLEDQAVTVRERDSMAQERIALDQVEGYLAQRLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEW1</accession>
    <name>A0A231HEW1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon monoxide dehydrogenase small chain</fullName>
            <ecNumber evidence="4">1.2.7.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">coxS</name>
        <name evidence="4" type="ORF">B7C42_00471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.4" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47348">
        <property type="protein sequence ID" value="OXR47348"/>
        <property type="gene ID" value="B7C42_00471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043885">
        <property type="term" value="F:carbon-monoxide dehydrogenase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="18663" checksum="7CF30CD1AEF42AD5" modified="2017-10-25" version="1">MTEVDIEVRVNGFRRRDAVPARLTLADYLRDRCGLTGTHLGCEHGVCGACTVLLDGAAVRSCLIFAVQADGAEITTVEGIAEPDGTLSAVQEAFRAEHGLQCGFCTPGFIVSATAFLRENPDPTDTEIREAISGNLCRCTGYQGIVRAVRAAAAAREPGAEPSTGDEADIAAPAARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF43</accession>
    <name>A0A231HF43_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47297">
        <property type="protein sequence ID" value="OXR47297"/>
        <property type="gene ID" value="B7C42_00419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="14642" checksum="E3DC8B245ED69DE8" modified="2017-10-25" version="1">MSNDLTVARELQAQAAACLRRCDIAVREEDGDALGFEYEGALCSLRGVTLAPGLDVLTLTCVLAWDRPLKPQLHKRVADRNNALQFGSLTIIAHEKLADVLLRYTFPAAGLDDDALATMLLLVLSGAGRARQGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFJ6</accession>
    <name>A0A231HFJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_00878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47753">
        <property type="protein sequence ID" value="OXR47753"/>
        <property type="gene ID" value="B7C42_00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="17358" checksum="2BA68869D1C8D690" modified="2017-10-25" version="1">MRRGGVVAEAAAWWLICVLIWQATVTVAAWEEVIAAAVLALPCAVAACAARRAVGGSWRPPAQLPRWTARTALAVVRDGAGALSLVARGRRPAGRFTELRLPATGSTAQRDGREAVATILLSATPGSMVVYSDPEHSRIRLHILPLPESALQRAVRTPDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFL3</accession>
    <name>A0A231HFL3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloalkane dehalogenase</fullName>
            <ecNumber evidence="2">3.8.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhmA_1</name>
        <name evidence="2" type="ORF">B7C42_00641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47516">
        <property type="protein sequence ID" value="OXR47516"/>
        <property type="gene ID" value="B7C42_00641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018786">
        <property type="term" value="F:haloalkane dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="32983" checksum="A0BE342023360D29" modified="2017-10-25" version="1">MSAFATRQRTTTVRGLEMFYREAGNPDHPTLVLLHGFPSSSHMFRHLMSELSDEFHLVAPDFIGFGNSAAPGVDEFDYSFDQLADITEQLLDQLGVRRFSLYIQDYGAPIGLRIASRNPERVTALISQSGNAYLEGFTPFWDVLFAHAKDRAANEAAVRELLEPKWTQWQYTHGVPADRMDRLAPEAWQLDQAKLDRPGNDAIQLQLFWDYQFNLEGYPAYQQYFRTHQPPTLITWGRNDEVFGAAGAEAYLRDLPNAELHLLDAGHFALETHGDEIATYIRDFLRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFV8</accession>
    <name>A0A231HFV8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH oxidase</fullName>
            <ecNumber evidence="4">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779658.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47830">
        <property type="protein sequence ID" value="OXR47830"/>
        <property type="gene ID" value="B7C42_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="6"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="385"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="644" mass="68914" checksum="DB40CA3714D0629A" modified="2017-10-25" version="1">MSFDALFRPGRIGPVELRNRVVKSPNSSATANMDGTISQRMVDHYRRLGEGGVGLIMTEYTYVDDDASKAIHNQPGMSRHEHIAGWGWLVDEVHATGAKIGLQLAHGGRQKFLGTAPIKSATDSSWDYVEAVAGVVPQPVTVAEIDDIVTAFAQAALRAWKARFDLVEVHAGHGYLITNFLSPHTNSRTDDYGGSFANRSRILIRIIDAIRAAVPRDFPLSVRVSVTDYESDGIPIEETVELCRLLEAHGVDVIHASGGHHATMEWEVSPWFNTRAPHRWGWEKFRPELSIPVIGSGSLVSPEVANDVIASGSADFVSLGRAMLADPDWTRKAQAGRTLEIVPCIRCNDGCLHRGVDKGRSVGCTVNPSVTEEGRFPITVSGTRKSVAVVGGGPAGLRSAAVLSDRGHEVRLFEPDELGGLLTHALGSTVKQDIAALVTHLVHEVRRRDIAVVPARATAAELVAGGVDAVVVATGAPLREPDFPIAAEVSHVPAAYVRAQTPLHGRVVVIGGGLQGCETALRIAEMSDTEVTVVEQQDSLLTGDEVIYDVLKLPQFLERAGVRIRTGAQVSEVRADGVAIRAADGDELLPADTVVTALGRVPASNELADELRSAGVDVHVIGSALRPGRVYDAIHSAFFTARAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFW1</accession>
    <name>A0A231HFW1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylesterase</fullName>
            <ecNumber evidence="2">3.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47774">
        <property type="protein sequence ID" value="OXR47774"/>
        <property type="gene ID" value="B7C42_00899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="30056" checksum="B3A5AF9E1FB79DF9" modified="2017-10-25" version="1">MYFTTTDGTTLAYEDYGTGEPIVFVAGAMLNTEMWEYQIPYFTERGYRCIALDRRGHGRSDRPSTGYDIDTTADDLGALLDHLDLRGATLVGHSTGGAEIARYLARHGESRVARVVFLAAILPFMKATDDNPGGIPEAMLDALVASIRTDRGRWLARQSQIYFNSHLNPDVSPEHIDITYRQCLSTAPWATLHMQQAVFHCDNREALRGITVPTLIVHGALDFSAPAEVTGRRTAELMPQAVYKEYPTAGHGLYTSHAAEFNDDLLEFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFY7</accession>
    <name>A0A231HFY7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mshD_1</name>
        <name evidence="2" type="ORF">B7C42_00720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47595">
        <property type="protein sequence ID" value="OXR47595"/>
        <property type="gene ID" value="B7C42_00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016794">
        <property type="entry name" value="UCP21603_acetyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021603">
        <property type="entry name" value="UCP21603_acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="174"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="34398" checksum="E89F2BA29D7AAEAF" modified="2017-10-25" version="1">MGVSRAGRILSLEPSKAPARRRRSWQAGSVRSVLEPSRRSRISGARQLADRDLAQVLEVLDTDPVAGCMVAARLQEYGLDNRGGGELWTRGTPADSLCFSGANLVPLRGTTDDMRAFADRAARWPRVCSSVVGRQELALPLWETLEHRWGPPREIRADQPLLALDGRAQAVPDPKVRRVRGDELERYLVAAVAMFTEEIGVDPRAGDGGRGYRRRVASLIEAGRAWARFEDGEVVYKAEVGAMSRRTGQIQGVWVHPQWRGRGLGTAGTAAVADAVVAAGRTASLYVNSYNEVARRAYAKVGFHQVATFATVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT15</accession>
    <name>A0A231GT15_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000078">
        <property type="protein sequence ID" value="OXR39722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782012.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000078.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39722">
        <property type="protein sequence ID" value="OXR39722"/>
        <property type="gene ID" value="B7C42_08201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17350" checksum="82D11BC69FC0D4B6" modified="2017-10-25" version="1">MGKKGKAAGKVDPETRARQQRCLDLKVRGMTYADIAEHEGYAGESGARAAVEAALARAEKQAADVVRPLMVARAEKLWEHGLGVMLEGRDEGDMERFAKGASVADKALARLMRLHGLDTPDVSVQIGAGAGELERLKNDFMLEINKAAGGVLDAELVEPEPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTB8</accession>
    <name>A0A231GTB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000064">
        <property type="protein sequence ID" value="OXR39795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39795">
        <property type="protein sequence ID" value="OXR39795"/>
        <property type="gene ID" value="B7C42_08135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="14717" checksum="B22248CDB348D85F" modified="2017-10-25" version="1">MLCEPMERLHHEFHAFFEGVRERTAGEKDLLRNTVVHSAPEPGPDRSVGGIGVGAEQEVVRMNEVVGIVVFVQFRKVVCPGDPEVVRFDADQKELVVIAVVRRPVLVAEQSVPNDQLPAPNLFSQARLVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTD2</accession>
    <name>A0A231GTD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778605.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39876">
        <property type="protein sequence ID" value="OXR39876"/>
        <property type="gene ID" value="B7C42_08051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="90" mass="9762" checksum="86AB6A24AABD28FA" modified="2017-10-25" version="1">MTLPMDERLRATPMRPVHCAQCGARVLARKSSWAQTSIQWDAASAAACVERHTAEALSGKPLPHCSQLRESIWAAARSGELPVLDEAPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTP4</accession>
    <name>A0A231GTP4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(S)-1-Phenylethanol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.311</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ped_4</name>
        <name evidence="3" type="ORF">B7C42_07917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.311" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000046">
        <property type="protein sequence ID" value="OXR39997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778650.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39997">
        <property type="protein sequence ID" value="OXR39997"/>
        <property type="gene ID" value="B7C42_07917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="295" mass="31056" checksum="07ADA94986894260" modified="2017-10-25" version="1">MTQRLSGKKALVTGSSRGIGRAIAQRLAAEGATVVVTARSHAPSPSVREGATHLLAGSLDETVQLIEAAGGRAVAIPADLEDAGQRGGLIDKVVTELGGIDILVNNAGFADYSSIEQMSDATFHRTVQHYLEVPFVLSRAAIPHLRKQGAGWIVNIGSSTGLNPIRPFREYNKTSGDVVYASVKAALHRFTQGLAAELLDDGIAVNAVGPSTAIMTPGASALLPEGYETEPVEYLAQTVLEMCTAPAAERTGLVAFSLHYPYATHTPVMSLDGSTELPRREPPSWANPNILPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTQ1</accession>
    <name>A0A231GTQ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000056">
        <property type="protein sequence ID" value="OXR39861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39861">
        <property type="protein sequence ID" value="OXR39861"/>
        <property type="gene ID" value="B7C42_08073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="23908" checksum="5A513FB602DCB099" modified="2017-10-25" version="1">MPGNTSSDDEEWARPNISPATNLGTDPETDRALEPVPDVAWLVPEPTPNPVPSLPRARLRGLMRRLPGRGWAALAAAIAVLVGVVAAVHGGHHPPAGRPNGAVPASVSVAAGACAGLAGAAVTDRGGDRATVPGVIATFEDAYYRLRSAEAAVQVLAPETGITLESLAAGIATIPIGTTYCVAITPVTSNTANVHIVELHPDHKRVDYLQVINTIPAPGPGADLLISHVQEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTZ8</accession>
    <name>A0A231GTZ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782567.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40089">
        <property type="protein sequence ID" value="OXR40089"/>
        <property type="gene ID" value="B7C42_07844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="183" mass="20543" checksum="0791262BE58D52AF" modified="2017-10-25" version="1">MAVIDPNRTWAPLEERLATTTNARHRQVLEIVIEHMKAEAKPDLDGLMRTLVPEPAYHFWNAGQDVGPKGWDGVHTYYSDFVASRSNILEYALDRLVVDDHCVVTEGFLKQIYPGAYAAQIGIPVDDTAADYLVVFRQLLLWPVDAEGRIVGEDSYHSGPVEIRKLSVDELPGEYVELVHSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU20</accession>
    <name>A0A231GU20_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_07833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40078">
        <property type="protein sequence ID" value="OXR40078"/>
        <property type="gene ID" value="B7C42_07833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20586" checksum="36E8727D80CB8F54" modified="2017-10-25" version="1">MMSTSAFDQALWAFGRGSGITALILLTVAAVAGIAARSGRAVLLPRAGLAEFHRSVALAATAFVALHVLTLFFDPYAQSRLLTVVVPFTGGYRPLWVGFGTLAVDLLAVVVITALLRHRLGPRVFRLVHWSVYALWPVALIHTLGSGSDVDRVWMLILVGACILAVATAGVWRFSRGFTEFTTVPERNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUC4</accession>
    <name>A0A231GUC4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpB_2</name>
        <name evidence="11" type="synonym">atpB</name>
        <name evidence="13" type="ORF">B7C42_07731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40216">
        <property type="protein sequence ID" value="OXR40216"/>
        <property type="gene ID" value="B7C42_07731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR40216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="30796" checksum="697B61E4AB92E7E4" modified="2017-10-25" version="1">MSRGRTRERMLSVTTLAGEFHAPSLQDFFPDALLFGGTPFEIDRLMMVRLIMVAVLVAVMLLAFRSPRLVPRGLQNVAEIGLLFVREQICDEVLGKKTGRRFFPLIATIFFTVLFLNFSSVIPLLNISSNARVGMPIVLAAIAYITFNYVGIRKYGFWRYMRSSVVVPNVPVALHVLLIPIEFVSTFILRPFTLTVRLMANMLSGHIMLVLFFSATQFFLFDAASWMKIFSPFSLLAGFGFTLFELLVIFLQAYVFALLTAVYISLAEHADSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUG5</accession>
    <name>A0A231GUG5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xerC_6</name>
        <name evidence="4" type="ORF">B7C42_07767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40185">
        <property type="protein sequence ID" value="OXR40185"/>
        <property type="gene ID" value="B7C42_07767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="142"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="37814" checksum="B5D18CAD3B730D15" modified="2017-10-25" version="1">MTSISTSDTIAAARLLLTQMGLSPADLVAPSLSIPTFGEIIPAVRATLEAGTRRTYGTHLNHLENHWGSARLNEISKPDLDELADTIRSAARTNRASRGGHSAVEHFIATVRCVYRYAEEHGWIRPADNPARQLTIPTRRKSHRYAIPSDRVTEICQAAATTGNDPELDALLLRLHLETACRRAGALSLRPHDLDTTQCLIYLREKDGTDRWQPVSPTLMNHLIAHAHERHSPQSEQLLRYRNGKPITHRRYDHLWNRIGQTLPWVATQGITTHWLRHTTLTWVERTFSYAVAREYAGHSSKNTGTTATYVKANLPEIAAALSVLTGEPHPLEDPNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUK3</accession>
    <name>A0A231GUK3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_07740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042078.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40225">
        <property type="protein sequence ID" value="OXR40225"/>
        <property type="gene ID" value="B7C42_07740"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="6">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="21828" checksum="6FDE7777F8C8DAE7" modified="2017-10-25" version="1">MSVHLTKIYTRTGDDGTTGLSDFSRVPKTDPRLVAYADCDETNAALGVALALGEPQARIAEVLRQVQNDLFDAGADLSTPVVPDPKYPPLRITQSYIDRLERWCDEFNAELAPLNSFILPGGTPLAALLHTARTVARRAERAAWAAVNAHPDDISVLPAKYLNRLSDLLFILGRVANPEGDVLWRPGGSETGGPAATDQPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUM8</accession>
    <name>A0A231GUM8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40278">
        <property type="protein sequence ID" value="OXR40278"/>
        <property type="gene ID" value="B7C42_07616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012714549" evidence="1">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="96" mass="10078" checksum="95F8CB7C2E18CCED" modified="2017-10-25" version="1">MNRAAMMPSTSSWRTPLRPARVKIPCFCSQSSASFTAASWAAAMRSATGLGAIAHNADTLLTGEKVISKPATAADFGREIFATNPDNSRSSNGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUS0</accession>
    <name>A0A231GUS0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40380">
        <property type="protein sequence ID" value="OXR40380"/>
        <property type="gene ID" value="B7C42_07546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="27276" checksum="5904357C415DF761" modified="2017-10-25" version="1">MTASTTPDIDLWSADWHAWRAERIALATAAHGLAAAIGTHWLGDEPIHIDGLPGAWVAVDGRAVGADADGFRVELEPGRGHVLGALLLQPLIRAGELALRVFDPQAATRTGLAGIDAFAPDRAWVIEGVAEKISATLRLDHIDGFVSENAASRIHLTVGGRDIAFEGVRTPEGDTQITFADATNGTETQRFRFLTVPPPNHSGRVTVDFNRAYLPPCTFSDHYLCPLPPAPNRLDIPIRAGETRLRYSDSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVB5</accession>
    <name>A0A231GVB5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778710.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40554">
        <property type="protein sequence ID" value="OXR40554"/>
        <property type="gene ID" value="B7C42_07363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23889" checksum="00A49B5BBA46B5A6" modified="2017-10-25" version="1">MPAPVILTGRLVRLEPLAPHHVPGLAEAGAADRDAFAFTPVPHGPAEAADYVAQAASAHAVGSALAFAVVATADNRVLGSTRFCRFDYWQGPMVWPIVHGMPTGDPLLAVPDAAEIGNTWLCPRARGAGINLESKLLLLEHAFDVWRVRRIALRVDVRNVRSRTAIERLGATSDGVRRAHSRGLDGTVRSTAFYSILDEEWPAVRRRIDTELGGVPRLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVM0</accession>
    <name>A0A231GVM0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40521">
        <property type="protein sequence ID" value="OXR40521"/>
        <property type="gene ID" value="B7C42_07460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="28706" checksum="D503873D61C4A1DC" modified="2017-10-25" version="1">MISLAGWARAIRAHHKLTRRQAERVTGISSDYLKNIETGIRPSLEYLENLIAGYRLDDAQARLTWDLWRPPLPLPPVEQLREQITTPDRLELLTRLDRAGIAIAYLDPLWNVLAANTTFRQTFPDAGANTEGNFALWALPPAPRQSPTASVMLEPGREAQFLVGMLRGGFGRYRRSPQVCSLYRQLTRNDAFNYHWHKGIHVAHGRDLQQPLRLRNPTTLQQYTLDLQITELTDFPAVRGFTAWPPPQLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVV2</accession>
    <name>A0A231GVV2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4352 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40744">
        <property type="protein sequence ID" value="OXR40744"/>
        <property type="gene ID" value="B7C42_07168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012691979" description="DUF4352 domain-containing protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="4">
        <location>
            <begin position="68"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="20212" checksum="F8C8FD2FF69342E1" modified="2017-10-25" version="1">MVWPWILIGCVILLCGGCFGIVGIAGTSSNSAAKASKTSTAASVPNAPAQQASKTPSAPRGPVVAAAGSEVRDGKFAFVVTAIDAPVSTLGENQFLRKTAQGEYIVVHVDVTNIGTKPQSYFGSNQKLIDEQGRQYTNDTMAEIDINDRGVIGADINPGNKISVAIAFDVSPGTVPASIEFHDSMFSGGARVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW49</accession>
    <name>A0A231GW49_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ESX-1 secretion-associated protein EspI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">espI_3</name>
        <name evidence="3" type="ORF">B7C42_07133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40849">
        <property type="protein sequence ID" value="OXR40849"/>
        <property type="gene ID" value="B7C42_07133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="351"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="605" mass="60456" checksum="08C764BDBF4F683C" modified="2017-10-25" version="1">MNRAPSTNGHAAEAVRARGGYDAFFAPVPDQPGAAPTGAGDSAASTSPASTSPASTSIAGNYPAAAGSAAQPSSEPAAGAMPADPARPAAPPVGPGAAPTGSAAVGSGATSAAQPGAIPAGPGQTSSAATGFAQPGSVPPESAQPGAAVTGSAQSGSAAAGPGPVAPSSAHPGTTHHGVNPSGAASSGVAQPGPVQPGPAQSAGVRAGAEPPAPTADASMSHAAPSAETSTASWHSASQTAAPTWQQTAASPQTAASTPYSAAPPAAARVPDRVERGVQSSERVEILPAALTSAELLADIAAAHRAQLKSTSGVRGALNKVGFNLGLSPSEQRKQDRRGRIRRQLNSTYQIAVISVKGGVGRTTVTAALGSTFARLRPDRVVAIDANPDFGDLPTRTRPHPYGLTLRDLVRSPNLEAFSAVHSFTSINDADLAVVASPWNTESVEALSGGEYSAAVEILRRHYNLMLVDCGTGVLDSATGSVLNTSDAVLVVTPATVGGVKGAVATLNWLNSHGMQHLIAKSIVAIVHHHPVKPTVEVDQIEKLFATAQRPTFELPYDAHLSEGGEIDLRLLDEDTGLAFEELAAALADGFPGSPMAGGDRGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWK4</accession>
    <name>A0A231GWK4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41007">
        <property type="protein sequence ID" value="OXR41007"/>
        <property type="gene ID" value="B7C42_06973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033458">
        <property type="entry name" value="DUF5134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17197">
        <property type="entry name" value="DUF5134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="216" mass="22283" checksum="77F3451FE9C8CE8E" modified="2017-10-25" version="1">MGSFVTEHEVLRWGVIVAFVAAAGIVLVRHVAVPVAPGGSGGPRPGTWPIGVDEHESDAAHLLMCLVMLAMLLFPAAAAPDAIRGVLIAMIVVYAGLSIVRIAHWRTTSGDGGAEFRLPAVVYHLVAAAAMLWVMAGHHHGMGHAELRGAGGPPVVPVALVAALFALDGLLLLFPRTRTALRHSISHPAGTPGAIGVVPHVVMDLGTAYMLIAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWW2</accession>
    <name>A0A231GWW2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate--isopropylamine ligase</fullName>
            <ecNumber evidence="3">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ipuC</name>
        <name evidence="3" type="ORF">B7C42_06856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41086">
        <property type="protein sequence ID" value="OXR41086"/>
        <property type="gene ID" value="B7C42_06856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="109"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="455" mass="50073" checksum="FA415D945C0BBE6C" modified="2017-10-25" version="1">MSSDRFEELTSVSRVRVEATNQDGVLIGKTLSPAKYRSCREKGIALPDLALGLDLNNNSALGFGFPEWRRNGTMSDIELRPDESTLVEWKPGVASVIGDLWTLQGEPIGADPRQALKRITAAYAERGLSILASVEIEATVFQESIDQARAQQYQNLTPLGGNAGAALVHAKSPDYVEYVEAVVARFDEIGIPWEAYSDEAASGQIEFNIAPADPVTAADRWARARQIMREVAYSLGRSITFMSKWSAAYGQGAHLNVSVSDENGNIFFDANKPGEPSERMLHFLGGVMATLEASTSFALPTITSYRRLMELEGPPTTQTWGVANKSCAVRAVPADNSATRLEYRLPSADSNMYCTLAAFLAGGLLGLDEKSTPPAPFEQMAWALVPGSVPAVPKNLYDAVAALDADDQLRRYLGDEFVDYWVGHRRWEWLSFHTEAERDDAQLSVWEFLRYFELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWW5</accession>
    <name>A0A231GWW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <ecNumber evidence="4">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hemL_2</name>
        <name evidence="4" type="ORF">B7C42_06848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41078">
        <property type="protein sequence ID" value="OXR41078"/>
        <property type="gene ID" value="B7C42_06848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="423" mass="44859" checksum="277073007932C9EB" modified="2017-10-25" version="1">MGIDSSRTAFERTRRSVGGGVSSGLRATMRPVPLFVERGHGAHLWDLDGDRYLDYVMAWGPLVHGHSHPQVVDAVARVATSMQVVGMGHRLEYEAAEAVLASVPGAQRLVWTNTGTEAVQVALRFARAATGRHRIVKFAKAYHGWHDSVYASMSADDTGESPVPAALGQSPNAHADLIISRFNDTAGIAELLAHAEERRIAAVLIDPIMSNAGVLTPEPGFLETLRSLCDRHGVVLIFDEVITGFRIARGGAAERFGVRPDLSVFGKAIAGGFTQSAVVGRADIIDLVEHGLTHAGTFNGNPVALAAVQASMELSATPGVFDKLEDLGDAFEQAITDVLVSAGAPGSLRRVGSLAQFVPRDQATSLHGTDGLWAEIAAGMLESGVVFMPSGKIFLSTAHTLTDIQETAARLERVLQHVSARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWW6</accession>
    <name>A0A231GWW6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41001">
        <property type="protein sequence ID" value="OXR41001"/>
        <property type="gene ID" value="B7C42_06967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="PTHR31544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="2">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16806" checksum="517C108AAEB27C67" modified="2017-10-25" version="1">MTAANKPAPQRRARPDDPGPDLFAYGTLQFGPVLEVLLGRTPDMDVAVARGWRVAALPQRLYPGLVAEPGRMAGGLVLRGLTAADWRIIEAFEDPEYDLRPIELIGCDEPVRTFVWSSAVTGNDWLPEVFVSHHLERYVERAAQWRQERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWY7</accession>
    <name>A0A231GWY7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41119">
        <property type="protein sequence ID" value="OXR41119"/>
        <property type="gene ID" value="B7C42_06889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="304" mass="33041" checksum="4EE0746F5F5D3B2A" modified="2017-10-25" version="1">MTLRQTREKIWKSLELWYGDVMSDPLDVLEKNIVALRRAIRDASGAGDAERASELRAQLRRAERAWDALLDTGEPAPVPLADATAGAKPKVLGSQAMMLPAREHAHRALMLLQAPAAPKLIVAVHEAFFPGELSTAKLSSLRRDEERSYRTAPGARPYYLCPALTHDLLGPARALITISTWSLEQRIIGPLSPRVDFLTSTINIAEAVHLARVAGTGPTPAALRLLWRFGATITDATVTTSTAGGAGVDPQRVIDAATAELEIHEAADQTTRAEAARRARKQLTEQQQLFGVSIRQINQVRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX67</accession>
    <name>A0A231GX67_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4,5:9,10-diseco-3-hydroxy-5,9, 17-trioxoandrosta-1(10),2-diene-4-oate hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hsaD_8</name>
        <name evidence="2" type="ORF">B7C42_06605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41207">
        <property type="protein sequence ID" value="OXR41207"/>
        <property type="gene ID" value="B7C42_06605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102296">
        <property type="term" value="F:4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="30290" checksum="5032B38395A28C16" modified="2017-10-25" version="1">MAPLQTPVITTTERVYDGYRTSELSCPGAGPTIILLHGILDLPQTWSQVLERLAAAGHRAVAMSLPQPHEQPIGTPVVPRQDEFVAAVIRAHAGSEGVVLVGNSMGGGLALRAAANPDLPVRAVVALDPIGFGTSRWISGLFVSRRVPEYLHDPIDLIRSLLRALVAPMVARVVFARSGDPVTTHARAVAAQLATIPIGLVLAGARALLTEFADGYSALPAVPVLFVHGRRDKLIPVRASILGHHQIRGSELRILPNAGHCPQVDEPQVVSDLIVEFTTRVARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXL3</accession>
    <name>A0A231GXL3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator KdgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdgR_5</name>
        <name evidence="5" type="ORF">B7C42_06649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41251">
        <property type="protein sequence ID" value="OXR41251"/>
        <property type="gene ID" value="B7C42_06649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="78"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="28937" checksum="D8A014642F1D625B" modified="2017-10-25" version="1">MTSADTPPRESGAGDPPSILSKAFDLLRAFNPYARVMTLSELARASGLPKSTVHRLLARLVELGVVEHHRGGYKIGLDMLQLCASTPAGYMRDLAMPYLTKLHRWCGHTVHMAVLRHYDVVYLEKLSVSESPTSITSVGARLPAHCTALGKALLAHENLDDLRDFLPRPLPALTPRSITGVEVLIDELRQVRADGVARECEEAQLGLACLAAPICMNGFAVGAISVGFPMEFAPPPNLAGALRATAAQIGSDVDAGLGGGRERWFPREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXX0</accession>
    <name>A0A231GXX0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41422">
        <property type="protein sequence ID" value="OXR41422"/>
        <property type="gene ID" value="B7C42_06565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="173" mass="18955" checksum="34792ED1C5DB7527" modified="2017-10-25" version="1">MAWALAAHAELAETATGYGHFITVNELAERIQDVSGVHTEAPTRTWMAAILRKVARRCHGAGEPPLTALCVRQNHTVGDDYKYVLELAGLPIPDDLELHAAYARWQCYQHYGAEMPAEVGVPPLTPKVDARRRGRGATKTVVAQEEKFSEPRPAVCSQCFIQLPAGGVCQYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXY4</accession>
    <name>A0A231GXY4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778284.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41493">
        <property type="protein sequence ID" value="OXR41493"/>
        <property type="gene ID" value="B7C42_06385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="128"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="35656" checksum="6DC8F66649A5F253" modified="2017-10-25" version="1">MSTRALGIRVALSVLAMAVVLAGVFRLIERPVDGDTDTYTAVFTDANGLRTGDDVRLYGVQVGKVRSVDLDGALARVRFTVTQGHPLYTETLVAVRYQNLTGFRYLEIRQPDQPGARRTSASGFDTAHTIPAFDITTLFNGLQPVLAQLSPDDLNRFASSMLAVVQGDGNGIGPALDAIDTLSRYASDRAQVLSILVNNLAQVSAHMAGKSGNAMQLMTNLTELFVTITDKLPGLVQFAMEIPPMLRPLLELLDVLGVTGEKNRDLDALLHRVLPGPRQAADVLGRLPGLIQTMATTVPPTGPDATMTCSHGIAAAPAPLAVLIAGQRITLCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY75</accession>
    <name>A0A231GY75_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41550">
        <property type="protein sequence ID" value="OXR41550"/>
        <property type="gene ID" value="B7C42_06443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="5390" checksum="17F5C81395331D9B" modified="2017-10-25" version="1">MTGWALCGFVVCIGLPLSVLIATLVVPQLIPKDRKVDAIRRRIENEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYU8</accession>
    <name>A0A231GYU8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41701">
        <property type="protein sequence ID" value="OXR41701"/>
        <property type="gene ID" value="B7C42_06342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="14207" checksum="F8C801682790499D" modified="2017-10-25" version="1">MALAVVDTRQWSRFSELASLINQSQKYHVSTIAGRGDIEGLGYRKRGLVVGPAEYLAGLQFGTVLVAGIPDLSHGSRTPSEITRLLSLLYLGISRAENEVRVFVNDDDGGVPEVLQRAIANSLVVLTKGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ31</accession>
    <name>A0A231GZ31_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mshD_6</name>
        <name evidence="2" type="ORF">B7C42_05860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41876">
        <property type="protein sequence ID" value="OXR41876"/>
        <property type="gene ID" value="B7C42_05860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="183"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="36111" checksum="2145C8AEC882CFF1" modified="2017-10-25" version="1">MIDYTWCRQLGEQDRDEATALVEVAARYDQEAGFSVVPPQVVAAVSDEMRSVWHLPIKARRDLSARADAPMVMVAYLNLTIDADGQGTVAYTVHPDYRSRGVTTLLVEELGLDVGTPDGWCGRGATALRCWAYGSHPASERLTRRFDIVPIARQWTMLRHLAGPFAVPVEPVALPGGVTVDGVDLTDGAVVAAAGEVLARQGLTAAQFDRFRSEFAERSGRMLLASAGCARPAGLVWFDPRPIRHLELRAAWVRALIVVPEIRGGGLGEALLTRTLDELRTVGAQLVLMRIDPDDHGAVRLLRLLSFEQEEAHACYQIGDWHDVAAFPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ46</accession>
    <name>A0A231GZ46_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41883">
        <property type="protein sequence ID" value="OXR41883"/>
        <property type="gene ID" value="B7C42_05867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013031316" description="MlaD domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="35028" checksum="98AE675CBE11CC42" modified="2017-10-25" version="1">MRQVIRRIVASETLLGTVVVATAVVALGATTLFYTHPVGQRTVAFETTDAAALSTGQEVRVAGITVGKVTKVSFRPDTVLVEAQVSDDTFIGDDSHVEVRMLTPVGGYAVTVVPLGRTPLGSRVIPVDHVTVPYSIGDVLQAAPHVTDKVDGATVDANIDQVAQALQHNSTSVGSLISGMNSIAAVMDRQRSQIEQITGLASEYLKSFDTNRDFVFDLIRQIDIVVSTYNNAHVGFNEAYSLLGDVLMRVQPEMKFYLDHKDQVRAVIDQVKNSIESLDTTTGPAIDKLQGLRAQLEAWLTPQGLATVSGGTILASNVCIPLPGRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZC1</accession>
    <name>A0A231GZC1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ketoacyl reductase</fullName>
            <ecNumber evidence="2">1.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">actIII_2</name>
        <name evidence="2" type="ORF">B7C42_05932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779008.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41948">
        <property type="protein sequence ID" value="OXR41948"/>
        <property type="gene ID" value="B7C42_05932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="27042" checksum="A20D66465B8A9DA7" modified="2017-10-25" version="1">MADSQRVALVSGATSGMGLQITKNLAAQGVAVFICARDEQRVADTAKQLQDDGFAVDGVGCDVRDAAQIREYVDAGVRRFGPVDILVNNAGRSGGGVTAQIEDQLWLDVIETNLNSVFYATKAALTAGGMLERGSGRIVNIASTGGKQGVLHGAPYSASKHGVVGFTKALGLELAKTGITVNAVCPGFVETPMAERVREVYSGLWGVDTDEVHARVSARVPIGRYVQVDEVAAMVDYLISPAAAAVTAQALNVCGGLGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZS7</accession>
    <name>A0A231GZS7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42100">
        <property type="protein sequence ID" value="OXR42100"/>
        <property type="gene ID" value="B7C42_05699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="169"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="36021" checksum="05D9008D2BE6AFAF" modified="2017-10-25" version="1">MQTATYLSIGGLLVVGGAVLAFLAAIRVALEPRRLSTGFVLLAAVTLLGVGGASAVVGLGPDAPSSFGLVVVFTAPFAVAGIALLVNGIELLSREGFAATTALPVVLGAGLIGAVAAVVTVASGPTMPSWAIASTVLVAAVAVYFVAHLIAFGGYALIYGSLAARPEADAVVILGCGLNRRSVTPLLAARLDRGIDAYRTALRSGRRPVLVTCGGQGPDEATTEADAMARYLTARGVSAHAIVRERHSRNTAENLRNCLRELNRRGIDPEQLRITVVTSNFHVLRTAGLTRRLGIDAQVLGSRTAAYFLPAAFLREFVAVLATHYRRSHITVAVSLLVVLLAVMALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZV7</accession>
    <name>A0A231GZV7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenylacetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">styD_3</name>
        <name evidence="6" type="ORF">B7C42_05745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.39" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42146">
        <property type="protein sequence ID" value="OXR42146"/>
        <property type="gene ID" value="B7C42_05745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008957">
        <property type="term" value="F:phenylacetaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="29"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="503" mass="53373" checksum="A974C74AC870D391" modified="2017-10-25" version="1">MTVVSEFPIRADVRAVLSGRKQLLIDGEWTDAGSGRTFPTHNPADGSVLAEVAHGEAADVDRAVRAARRAFDNGPWQWMKPNERERLLWRVGDILSERAEQFGELEALDNGKSATIATVVDTAWAADVFRYYAGWATKIVGSTVDVSMPFAPPGSRFHAYTLREPVGVCGLIVPWNFPLLMAAWKLAPALAAGNTVVLKPAEQTPLTALLLGEVFQEAGFPPGVVNIVTGFGDAGAALAAHDGVDKVAFTGSTEVGKLVVDAAKGNLKKVSLELGGKSPNVVFADADFDAAVTGSLNAWLFNHGQCCVAGTRLYVEDKIFGDFTGAVAEAASRVKIGPGLDPATELGPLVSQEQFDRVTGYLQAGLADGATALTGGGRHGDTGYFVQPTVFVDVRPEFSIVREEIFGPVVAALPFDADEGLAAAAHQANDSIYGLAAGIWTRDISKAHRVARELKAGSVWINQYNGFDTAMPFGGYKQSGWGRELGPDGLDLYLQTKSVNVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0C4</accession>
    <name>A0A231H0C4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42306">
        <property type="protein sequence ID" value="OXR42306"/>
        <property type="gene ID" value="B7C42_05505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="480" mass="53715" checksum="976BB6659242ECD4" modified="2017-10-25" version="1">MVKSANYEKPPANPRPEDAIVSMLAELAGVLLLGIAHLVWWSALFPMLSLPLVAVGVVWWWQGWPLGAAALIFSLGAWGLWWAWWPMSWRRLVWGRMRGRYLTWVRYRRRWKTTTAMHGLTTVLDTGVLTPRLHKVVIGDTADVLRVKLLAGQTVDDWAKKSDALRNAWRALGVRVRKIESGCVLVQVIHTDRLADPIPLPRTVPEQVDLEALTIGMTELGRPWRIRLLGSGVLVAGIMGAGKGSVAWATIAALGPAIREGRVVLWVLDPKGGMEFGAARKWFARFEYDNSSGAVQLLRDAVALVQARGTKYRDRWERKITPSVEEPMVFIIIDEHASLTAHYSDRKIKDEISRLLGVLLTQSRAVAMPVMGCLQDPAKDTLDQRQYFPYRVGLRMTEPTQPNMLFGLSGRDRGALCDEIPESMPGVGYVEEEGSSEITRVRAYQVTDDDIAWIMRTYPPLPRRDGQLTQSGGDPGPTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0D9</accession>
    <name>A0A231H0D9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780633.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42344">
        <property type="protein sequence ID" value="OXR42344"/>
        <property type="gene ID" value="B7C42_05543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="29527" checksum="2904354CE9415BEF" modified="2017-10-25" version="1">MRTTSNPIFKNLPQQQGGGYAGFGSAAAGAGQFAQYGQQSPYGVQQPYQQAPATRPMTIDDVVTKTGITLGVVTLAAIIAYGATAANHALAPLFVIVGGLVGFVLVMVATFGRKQDNKAIVLSYAAAEGFFLGALSFMFTNVEFGGVGGGGLIAQAVLGTFGVFFGMLVVYKTGAIRVTPRFTRMLVGAMIGVIVLMLGNLIAAFFTPGGFGLRDGGTVAIIFSLVCIAIAAFSFLLDFDAADQLIRAGAPEKAAWGVALGLTVTLVWLYLEILRLLSYLQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0H7</accession>
    <name>A0A231H0H7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enduracididine beta-hydroxylase</fullName>
            <ecNumber evidence="9">1.14.11.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mppO</name>
        <name evidence="9" type="ORF">B7C42_05585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clavaminate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.40" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42385">
        <property type="protein sequence ID" value="OXR42385"/>
        <property type="gene ID" value="B7C42_05585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014503">
        <property type="entry name" value="Clavaminate_syn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019543">
        <property type="entry name" value="Clavaminate_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019543-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR019543-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="39500" checksum="031925E765057E55" modified="2017-10-25" version="1">MKNVLRERKTPQHQETEPIDRRTLPPEAAAAVFCSAEEIAITLDRTPGGSAPIRRTLSDPALIRLVDAFAADLPAAVRTALRPPDTAAGATIIGRLPVRDDELGPTPSDWTHAAEPACPASFRLDIALLLLARCAGEPFGWQGQQGGRLVNNILPTPGHEHEQSGASSTTLLSPHTEDAFHPERAHLLLLGCLRNPDRVGTTVSSVRRVNLDADGRRLLAEPTLPILPDVSYGGDFSGHRPAPVATVGAGDGGPTLRYDPAYTPLDDAAPEYRCAYAHLGTELERVCHRAVLEPGELLLMDNDVVVHGRVPFTPRYDGTDRWLKRVNIRLARRRAPAEAGESGYGQRTVRPFAPNPADAPQISHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H125</accession>
    <name>A0A231H125_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42549">
        <property type="protein sequence ID" value="OXR42549"/>
        <property type="gene ID" value="B7C42_05326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="524"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="814" mass="87961" checksum="C472E56E9981AA2D" modified="2017-10-25" version="1">MLRARLGIRTRILAIAVIPSLTLLGIGVGTAGYLVREGQHAKDWASILGNANVHTREMIAAVEQERMLSLWHLAGEHGDPAALGAARTRVDNALQALAATENKLMTSGSNPMGDDTGGFETLKKQLPAIRGGIDAGALPIPETYAIYNRILDAVVVGTNLTIPTAPDAAVAQQLAGGLRTLHAMEGMSRSAALTAAELNGQILAGQLRDDYRNLVGYYRTELPQLAADLTGPPADKIKTVLASPAWQQLAAMEDYLIHPPAPGKNGELPPPPMSFADWRTSAEQLGDQLLAAWQYQNDHANQTAVDDGDRTATNSLWAGAGVLAIAIIAFLLSLWLANRLIGRLKRLRTETLALAEVRLPETMRRLSEGENIDAETEAARLDFGHDEIGSVANAFNRAHTAAVSAAVTEARTREGVRAVFLNIAHRSQIVVHRQLEILDEAEQRQEDPALLETFFRLDHLATRERRNAENLIILGGGEPGRQWRRPVPLVELVRSAIGETLDYARVRAHRMPQVFIVGNVVADLIHLLAELVDNATSFSPPQSRVEVSSNVVGKGVAIEISDQGMGMPADELERANEMLRNPPDFGVATLSANSRLGLFVVAQLGARHGISVRLSESDYGGIRAIVLVPTAVVAADAPLADHLPERFGGRRPEPAMTGEMPAIPSAETTSAATSLATLTSPQPQAWSDYPRTGSAPSTDERSWADTPARREAPPRPELPATPTDQPARRSPQRPSYTGSDARPPLPRRRRQASLAPELAHDPQPDAASPQRPRSAEQARDLMSAIENGTRQGRRSQPGHTPDEQEGEGDFFQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1J9</accession>
    <name>A0A231H1J9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42711">
        <property type="protein sequence ID" value="OXR42711"/>
        <property type="gene ID" value="B7C42_05048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="21107" checksum="6CCA4EACC773FCDB" modified="2017-10-25" version="1">MAGATGVLGARLTPLLVSAGFEVAGLTRSESKASMLTGFGARPVVCDVYDAAALEQAVRDFAPDLVMHQLTDLPDDPADLPAGRAANSRMRREGTANLLAAAQAAGAKRFLAQSVAWEMTGEGQAAKEFLEDAVLGVRGVVLRYGQFYGPGTYYPENTDRPDPPRIHIAEAAARTVVALDLASGIYAVTEDGRVDFEPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1X5</accession>
    <name>A0A231H1X5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter YycB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yycB</name>
        <name evidence="7" type="ORF">B7C42_05165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42827">
        <property type="protein sequence ID" value="OXR42827"/>
        <property type="gene ID" value="B7C42_05165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="415" mass="43513" checksum="C65BEC5B7F990089" modified="2017-10-25" version="1">MTVTPLQSTTDIRRRGLAEGRILVLVAIVVSALTLRVAVTAFTPLAERIGADIGYSTAIVGVFGMIPTAMFALAGLITPIFVRRLGLERTALVAMCMAGAGQLTRALVPDTWELLSLSALALAGMGIGNVVIPPLVKRYFADRLAVLSSVYITMVQIGTVVPALIAVPVADAAGWRVSLGLWALLGFAAVVPWLGVLRGRRGHDRADTTAVAEVPGEQPARASNIRRSPLAWGMAAMFGMTSLVTYSMFTWLPKLFADAGADASFGGTMVAFFSFMGLAAALTAPSFTARIRNPFPVVIGCAIAFFAAFAGLLIAPMSAPWLWVLLLGLGPSTFPMALTLINLRTRTQAGSAALSGFTQGVGYTVACVGPLLFGVLHSVVGGWGAPFALLAVAVLVLVAGAWQACKPRMLEDTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Y9</accession>
    <name>A0A231H1Y9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA base-flipping protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atl</name>
        <name evidence="2" type="ORF">B7C42_05201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780172.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42863">
        <property type="protein sequence ID" value="OXR42863"/>
        <property type="gene ID" value="B7C42_05201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10869" checksum="0C06524F31483A74" modified="2017-10-25" version="1">MPTTDAEIERVRELVAAIPPGRVATYGDIAAAAGLSTPRTVGWIMRTDSADLPWHRVLRADGTPASHLVQRQLRRLAEEGCPIRGDRVDLAAARHRFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H217</accession>
    <name>A0A231H217_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Resuscitation-promoting factor RpfE</fullName>
            <ecNumber evidence="5">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpfE</name>
        <name evidence="5" type="ORF">B7C42_05226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780150.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42888">
        <property type="protein sequence ID" value="OXR42888"/>
        <property type="gene ID" value="B7C42_05226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011278877" evidence="3">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="4">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="18792" checksum="F158A180A793CECF" modified="2017-10-25" version="1">MNKNRKISSRALGFAAVAGALVAVPFAASTTASAAPAHDWDGVAQCESGGNWNINTGNGYYGGLQFTQSTWSANGGSGSPQNASKDEQIRVAENVLQTQGPGAWPVCGQYLRYAPAEETQPAPAPQPEPTAPVQLPNDRQDLINKATDAGQQAAQRFGVGHQFQQILEQNSGLIDSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H269</accession>
    <name>A0A231H269_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase A inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kipI</name>
        <name evidence="5" type="ORF">B7C42_04822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778375.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42936">
        <property type="protein sequence ID" value="OXR42936"/>
        <property type="gene ID" value="B7C42_04822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="21900" checksum="D3B9DD33E996288B" modified="2017-10-25" version="1">MSALTVRPAGDRALLLEPADAAQLPLLLDHLRRAPIDGVADLLPAARTVLLTLCPGIDPAAIESRVRALDLASGADADGVAEAETVTVPVCYDGPDLADAADHLGVSPGELVERHTAAHWRCAFVGFAPGFGYLHAPDAGLSVPRRPQARTAVPAGSVALAGGYSAVYPRSSPGGWQIIGRTDLVLWDVARPEPALLRAGTRVRFVAVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2D0</accession>
    <name>A0A231H2D0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RsbT co-antagonist protein RsbRA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsbRA_1</name>
        <name evidence="2" type="ORF">B7C42_04886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518330.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43000">
        <property type="protein sequence ID" value="OXR43000"/>
        <property type="gene ID" value="B7C42_04886"/>
    </dbReference>
    <dbReference type="GeneID" id="66719508"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="169"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="32888" checksum="440A7D0A36104498" modified="2017-10-25" version="1">MSDVSIGLSPDSIPAGPVENLLPQLVEHLRQNRTELREEWARRIGDAALLTAMTPEEIFSEATSIYDNYVEALQTGSVEALQAYARDLSERIIPRGVETDEVVGIVLLLRDVLARSLFEKYQSDFELLKRVLDAYEPAANRIANTVAISFVQERERVIRQQQEAIRELSTPVLQVREQLLILPIIGVLDSQRARQLTEQLLRAIRANRAKVVVIDITGVPMIDSTVANHLVQTVDASNLMGANVIITGLSSEIALALVTIGLDLTKMNAVGDLQGGIEEAERLLGYEISRLTDRDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2E8</accession>
    <name>A0A231H2E8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43021">
        <property type="protein sequence ID" value="OXR43021"/>
        <property type="gene ID" value="B7C42_04907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="44037" checksum="593BA33A59713585" modified="2017-10-25" version="1">MAPQNSADPAMLHRTELTRTYPCAACGGQLVFDIASQRLRCPSCGNYSPLSAPRAPVVARDLRQAMGELRALQAVTAGPEVTGEREVKCQNCGGTTTFVGSLTATRCPYCATPIQRDDVHNAPARLPVDGVVPFRIDEKTARERVEKWVSGRWFAPTAFKKYKRLGSLASVYHAYFTYDADVHTWYRGERGEEYTERYWDDGELKSRTEIRWYPAMGEVGNRFDDLPILANDIDDSARVAELEPWPVADATGYSPEYVAGHLARTYDRDAEQMFPVARTRMEKVIEQTVRADIGGDRQRVHDLRSSWNSLAYKHILLPIWLLTVVYANTPFRVYINGLTGEVVGQRPWSKVKLAAFVTVVTLLIIGAVVAFSMWHGGGTHHHSTGHTTVVHHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2S2</accession>
    <name>A0A231H2S2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43127">
        <property type="protein sequence ID" value="OXR43127"/>
        <property type="gene ID" value="B7C42_04549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="5128" checksum="C340853AE4FBC798" modified="2017-10-25" version="1">MITRQMYPAPVLVTDTGANITDSTAPRIGSPYFADYLFGNILGGPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2X2</accession>
    <name>A0A231H2X2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase 2</fullName>
            <ecNumber evidence="3">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB_5</name>
        <name evidence="3" type="ORF">B7C42_04614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909004.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43192">
        <property type="protein sequence ID" value="OXR43192"/>
        <property type="gene ID" value="B7C42_04614"/>
    </dbReference>
    <dbReference type="GeneID" id="66723502"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="30247" checksum="487B68428044FC9D" modified="2017-10-25" version="1">MSLESAPIASATLLDLLELEQIDRDLHRSVVLFDEPFSLYGGQVAAQALYAAGRAVPPGRLPHSLHCYYLRGGSAARPVLFRVDRDRDGRSYSARRVTALQDGEVIFTMSASFATPRRDADHEVEPMPDIAAPELLPEWEFERMWSMQARVPPQRTRSTPWPSRFWARSAIELPDSPLVHACVLTYLSDTSSGLVDVPGGAQWAGSTLDHTVWFHRPARLDEWVLVDLLPRTVAGGRGLYTGTVRRADGATVATLAQESLFREPPPGRPLPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H327</accession>
    <name>A0A231H327_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ferredoxin/ferredoxin--NADP reductase</fullName>
            <ecNumber evidence="13">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fprB_3</name>
        <name evidence="13" type="ORF">B7C42_04681</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43259">
        <property type="protein sequence ID" value="OXR43259"/>
        <property type="gene ID" value="B7C42_04681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="296"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="471"/>
            <end position="473"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR43259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="557" mass="60179" checksum="E37A2B4DB71DAFB2" modified="2017-10-25" version="1">MAFVVTQRCCNDASCLSECPVDCIRPRPEDPDFATAEMLYIDPQTCIDCGACADACPVDAIYSEDELPEGLQRYTDINAGYFERHPLDAKMIQPAPPGRVAKELGTLRVAIVGAGPAAAYAAEELMRRADAEVEVIDRLPSPHGLVRAGVAPDHAGTKAITMTFEAAARHAGFRYLLNVEVGEHISHAELMDHHHAVIYAVGASADRSLGIPGESLPGSHSAGEFVAWYNGHPDYADRVFDLSGERAVIVGNGNVALDIARVLTLDPEELARTDIADHALAALRDSTIREVVLLGRRGPVQAAYTSPEFLALQRLPGVDVIIDESELKLDSASQAVLDDPGTEPSTLLKVELAREYSQQAQHPGHKRIVFRYLTSPVEILGTDRVDGLTIVRNELAESGGELTPRPTDCTETIATSLVLRSVGYRGQPVPDLPFDESRHIVPNERGRVVTAEGDPVTGVYVTGWIKRGPRGVIGTNKACAQETVAGLLDDFAAGMLPAPRHDRRALHALLAERRPELVDGTGWRAIDAAERELGKRQGRPRVKFVSVAEMLAASRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3E6</accession>
    <name>A0A231H3E6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase PknK</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein kinase K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pknK_4</name>
        <name evidence="8" type="ORF">B7C42_04252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43385">
        <property type="protein sequence ID" value="OXR43385"/>
        <property type="gene ID" value="B7C42_04252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016236">
        <property type="entry name" value="Ser/Thr_kinase_PknK_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000574">
        <property type="entry name" value="Ser/Thr_PK_PknK_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124365" checksum="062ACA0DE3F6E807" modified="2017-10-25" version="1">MADKDSMATQRDRSLVIDDDLRAAGFADAHIIGRGGFGVVYRCRELALGRTVAVKVLTATSEFGDENLERFLREQRAMGGLPEHPNIVAILQVGTTGDGRPYLVMPYHPKGSLDQRIQHGGPLDVTAALRMSVKLSGALETVHRAGILHRDIKPGNVLLSDYGEPQLTDFGIARVEGGFRTTTGVVTASPAFTAPEVLRDGTPTVASDIYSLGATLFCMLTGHAAFQRRSGERLVAQFVRITEEPIPDLRPGGIPDDTCALIEDSMAADPAQRPVSAAEFGERAQQLQRHRGLRVDEMAIPAPEPPAAEPAAVADRVGEPTRLGLLPPADPVTTPPTAETKFHPALPARPLVRRPRLLDSMDRDRWPRLIVVHAPAGFGKSTLAAQWGQRMVGRGVATCWLNIDDDDNNPVWFLLHLIEAVGRARPALTTELLRVVEEHGNDVMRYVLTTLINRIHADGERIVMIIEDWHRVTDADTTAALRFLLDNACHHLQLLITSREMIGLPLSAIRVRDDLIEIDSAALRFDQDETADFLTRVGGLTLDSADIDRLRSGTDGWVAGLQLASISLRGREDPGSAIATMSGRHQAISEYLTDNVLDALEPDLLTALLDTAVTDKVCGSLASELTGRPQGRALLEDIERRDLFLRRLDDDGEWFRYHTLFSDFLRQRLERDHPDRVPRLHRRAAEWFAAHDMLSEAIDHAMAAGDPGRAVALVSAHARELVQHSHLATLAALAAKLPVTEAAADPTLQIALAWAAVLLRRPSRMHTALQLALAADSAKQPPGHRKSDLAVEASILCGVEAALADRLDGLEDIVEQSCARADSLAPFVLSAAANLGAFTALHRFDFDRVHEWHRWGRTYFRHITGALSIMYSHCFAGMAAREQLDSEAAEEHFRTALHLARTTTGESSLTARLASAALGDFLYDRGEIAEARHLLGVAVEFGFDGGTVDFLTGVYGTGARIEALRGDLAAARRLLADGTEVATAHTLPRLSARIELERIRLGFAESGPGEPPAPHGARDGVATTIHDLTEEAAVRWLLCADPERALPRARDLRESIDTAVRPRAALCATLLFANCLETVGRSEEAETVLAPALRRCVEAGLVRPLIDEGPALLAVARRLSGETGRHSAGTPAIALPRTFLDQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3H4</accession>
    <name>A0A231H3H4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43419">
        <property type="protein sequence ID" value="OXR43419"/>
        <property type="gene ID" value="B7C42_04286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="8965" checksum="B083A126BD9AA894" modified="2017-10-25" version="1">MDLSITVVGNATTLLSFGLTVTMDGMQGAGLVDLLREPRAVPVHYDDYTVFASPLAEFRDRMRQRGGADRIVEIPRGDTVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M8</accession>
    <name>A0A231H3M8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779250.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43513">
        <property type="protein sequence ID" value="OXR43513"/>
        <property type="gene ID" value="B7C42_04381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011231000" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="59" mass="5668" checksum="50989B81AA9E5FFA" modified="2017-10-25" version="1">MHAIKFRKAAAVAAIAVALGAVVAPAASASTPSGASPTASDIDGSVAICFPLGSVVWCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3N6</accession>
    <name>A0A231H3N6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">apt</name>
        <name evidence="12" type="ORF">B7C42_04356</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43489">
        <property type="protein sequence ID" value="OXR43489"/>
        <property type="gene ID" value="B7C42_04356"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="68"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR43489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="19580" checksum="8767E5977BFFC595" modified="2017-10-25" version="1">MSKHTMVETAETAEEKVARTAEVVGRLTRWHDDFPTPGVRFADLTPVFADAEGFHAVIECLAACAPDADLVAGVDARGFLLGAGVAALLGTGVVAVRKGGKLPPPVLSREYTLEYGSAALEIPADGIDLTGRKVLLLDDVLATGGTLAAAAELFRTAGAQVVAAAVVLEIGELGGRARQGDYALTSIVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Q2</accession>
    <name>A0A231H3Q2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43509">
        <property type="protein sequence ID" value="OXR43509"/>
        <property type="gene ID" value="B7C42_04376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="128" mass="15043" checksum="85B97A2B2400683E" modified="2017-10-25" version="1">MNDQPQDMIYSNVVEFVENYLSLIYRRQVTDLTDTVWCPEWWKHAEAAMRLEALWRAWEYLRQDPQTGMSVWFLDHADPHMNKLFDPRGPFKYCSVRNGHKDMLSPLPLTPPQQGMFGEPSNADPNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H435</accession>
    <name>A0A231H435_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ctaB</name>
        <name evidence="8" type="ORF">B7C42_04493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778891.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43625">
        <property type="protein sequence ID" value="OXR43625"/>
        <property type="gene ID" value="B7C42_04493"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="35297" checksum="1A6797C410AB8A94" modified="2017-10-25" version="1">MRIGQQPGDAHGSSATALADRVQGSGPLSKLTRRVLAYIALTKPRVIELLLVATIPTMLLADRGHVDIRLIVATLFGGWMGAASANTLNCVADADIDKVMKRTSKRPLAREAVPTRNAFVFGVALGAGSFAWLWWQANLLSGLLVVATILFYVFVYTLGLKRRTSQNVVWGGAAGCMPALVGWSAVTGTIGWPAIALFAVIFFWTPPHTWALAMRYKDDYRAAGVPMLPVVATERVVTKQIVIYTWLTVLATLALIPATGVVYAAVAIVAGAWFLLMAHQLYSGVRRGASVKPLRLFLQSNNYLAVVFCGLAVDSVLGWHTIGSTLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4D4</accession>
    <name>A0A231H4D4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43697">
        <property type="protein sequence ID" value="OXR43697"/>
        <property type="gene ID" value="B7C42_03932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="29513" checksum="87E118557FCB9634" modified="2017-10-25" version="1">MRENSAEERPRRARATGERSGAGDPARTLELLWRQPGRAPTRGPKQRSSVDEVVAAAVEIADSEGLAALTMRAVAAKLGLTPMATYTYVPGKAELLDLMLDSVYARMPRTELTGKHWRERVATVAQDNRSMLARHRWVAYVPTTRPPLGPGLAAKYDHELSAFDGLGLSDVEMDAALTYLLGFVTAVSRIAIDTDRAAADSGLSDREWWERTAPVLEQVFDPQRYPLAARVGSAAGQAHDSAYSADHAWDFGLARVLDGLAILVERSGTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4F2</accession>
    <name>A0A231H4F2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030516156.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43744">
        <property type="protein sequence ID" value="OXR43744"/>
        <property type="gene ID" value="B7C42_03979"/>
    </dbReference>
    <dbReference type="GeneID" id="66724355"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="98" mass="10625" checksum="2882DAF47F01FFEE" modified="2017-10-25" version="1">MGAVYQLTSAILWLLWLAAMAATIFALVHAIRQRADAFTAVDKLTKPIWVSILAVALGFLLLARTPVGLLGIAAVIATGIYLADVRPKVDEIQRGPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4H0</accession>
    <name>A0A231H4H0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-glyceraldehyde 3-phosphate reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gpr_2</name>
        <name evidence="2" type="ORF">B7C42_04078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781121.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43843">
        <property type="protein sequence ID" value="OXR43843"/>
        <property type="gene ID" value="B7C42_04078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="37547" checksum="B79761581870C084" modified="2017-10-25" version="1">MDYRRLGASGLLVPALSFGAGTFGGRGELFEAWGDTDAQQARRMVDVALEAGVTMFDTADVYSDGASEEILGQAIRGRRDRVLLSTKAGLPTGPGASEAGSGRSRLITAVDAALRRLGTDYIDLFQLHAFDAATPIEEVLDTLADLVRAGKIRYLGASNFAGWQLMKSLAAADRGGHPRYVAHQVYYSLVGRDYEWELMPLGRDQGVGAMVWSPLGWGRLTGKIRRGQPLPAGSRLHRTAEAGPPVDDELLYDVVDVLDELAAETGKSVPQIALNWLLSRPTVATVIVGARNEEQLRQNLGAVGWQLEPEQLARLNKVSAVTPPYPYYPYYRLPDFARVNPPIGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4K1</accession>
    <name>A0A231H4K1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43794">
        <property type="protein sequence ID" value="OXR43794"/>
        <property type="gene ID" value="B7C42_04029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="24010" checksum="E5457C37E9FF0B15" modified="2017-10-25" version="1">MSDAQPTAAVRPDSVLFSEPGARWRTVAYGPLLCLLVLILELALRRGPVHWFGLAFCAILLAGFVTLQVVAGKRHVSVELTDSVLREGTETLPLESIARVFPELDEESWDDEPWESARALGELTGVPRRRRGIGLKLRDGAMVQAWARDHQQLRAELSAALDRLAQESAPAAKKSAAADSPAKESAVLAASADDAENSVVAFDADSEGAAASEGKIGSEGREDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Z6</accession>
    <name>A0A231H4Z6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="7">1.13.11.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hpd</name>
        <name evidence="7" type="ORF">B7C42_04149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43910">
        <property type="protein sequence ID" value="OXR43910"/>
        <property type="gene ID" value="B7C42_04149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="40"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="198"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="44413" checksum="BBD6247244E637AC" modified="2017-10-25" version="1">MTIEDLSRDTRPAVPGDAELRRLVGLVDHDPGADPFPVLGWDALVWVVGNATQFTHYLQAFGMVLEAYSGPETGNRDHKSFVLRSGSARFVVCGAVDPASPLVAHHDRHGDGIVDIALEVPDVDRCIAHARRHGARILVEPHDTSDEFGTVRTAALATYGETRHTLVDRSRYHGPYLPGYIARRSGYQPRAPHRLFQAVDHVVGNVELGRMDEWVEFYRRVMGFTDMAEFVGDDIATEYSALMSKVVANGNHRVKFPLNEPAAGRKRSQIDEYLEFYGGPGVQHIALATGDILSTVDALRREGIEFLDTPDAYYEDPELRARIGHVRVPVRHLQSRGILVDRDEDGYLLQIFCKPLTDRPTVFFELIERHGSLGFGKGNFRALFQAIEREQHARGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H549</accession>
    <name>A0A231H549_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C(11)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cobM</name>
        <name evidence="8" type="ORF">B7C42_04199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43960">
        <property type="protein sequence ID" value="OXR43960"/>
        <property type="gene ID" value="B7C42_04199"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="26721" checksum="E1043835CDD47A63" modified="2017-10-25" version="1">MTVHFIGAGPGAADLLTLRAVALLRESPVCLYAGTYLDPEVLAHCAPEAELIDTQGLDLDEIVAHCARADAAGKDVARLCSGDPSIYSALTEQTRRLDGLGISWDVTPGVPAYAAAAAALGSELTVPEVVQSVVLTRTQARSTAMPESEALGNFARTRASLVLHLAITRIRELAAELADEYGVDCPAVVVYRASQPQQRILRGTLADIAGRVEAAGLRQAAVILVGRALTPALDCAQSHLYDPGRERHPVSGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5A3</accession>
    <name>A0A231H5A3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mraZ</name>
        <name evidence="10" type="ORF">B7C42_03680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514722.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44123">
        <property type="protein sequence ID" value="OXR44123"/>
        <property type="gene ID" value="B7C42_03680"/>
    </dbReference>
    <dbReference type="GeneID" id="66721644"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15838" checksum="6E12AD65612F883D" modified="2017-10-25" version="1">MFLGTYTPRLDDKGRLTLPAKFRDELAGGLMVTKGQDHSLAVYPKEEFTALARRAAAASRSNPQARAFVRALAASTDEQRPDGQGRITLSAEHRRYANLSKDCVVIGSVDFLEIWDKQAWDSYLAEHEEDYSLAGDESLGGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5A4</accession>
    <name>A0A231H5A4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44020">
        <property type="protein sequence ID" value="OXR44020"/>
        <property type="gene ID" value="B7C42_03576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="34827" checksum="3F3C9B77CBB02093" modified="2017-10-25" version="1">MLVAAVVFRGWWWELCVRWSRGPLPEANLLLGHSVLFWGRLGKGLQFVAGLPVIFDLIGAAALNEFGRRHVKRLRRAKNRITATRDAARLLERLRALECRVKSDLTVGQRGRATPEYESLLASLVETFDGELMCASCKPAMPPVSEVDGIVVVGPDPCVYKWECEHGQKAFESRVEAAFIDTLAGSDKTAWRSAEYVDRRVERIGSVLLGVLALVAPTYLIAQWTVGSHLPGLMVALAIGLVILAPLTYLTTEPDKRHRAGAVLAWLWAAVCWLPVPITRSIVWVMHREHPAHPLRWIASGLFIFGSLLDLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5B1</accession>
    <name>A0A231H5B1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Group 1 truncated hemoglobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glbN_2</name>
        <name evidence="5" type="ORF">B7C42_03600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="4">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the truncated hemoglobin family. Group I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44044">
        <property type="protein sequence ID" value="OXR44044"/>
        <property type="gene ID" value="B7C42_03600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019795">
        <property type="entry name" value="Globin_bac-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016339">
        <property type="entry name" value="Hemoglobin_trunc_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002030">
        <property type="entry name" value="Globin_Protozoa/Cyanobacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01213">
        <property type="entry name" value="GLOBIN_FAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002030-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="14533" checksum="CC78CED74AFCFA01" modified="2017-10-25" version="1">MRISSLFSKSSAAPSAPAPSIYEQIGGHEALETVVEDFYVRVLADEDLAGFFTGTNMSRLKGRQVEFFAAALGGPEPYTGAPMKQVHQGRGITMHHFTLVAAHLTDALVAAGVQEPTVGEIIGAIAPLAPDIASDAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5I5</accession>
    <name>A0A231H5I5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_11</name>
        <name evidence="3" type="ORF">B7C42_03641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44085">
        <property type="protein sequence ID" value="OXR44085"/>
        <property type="gene ID" value="B7C42_03641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="410"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="494" mass="53449" checksum="100A92569CD3D028" modified="2017-10-25" version="1">MNATLSLASILAEPARRRPDHVALIEGDRRLTFAELWRAARQQAGALIARGIRPGDRVALMCPNTADFPRAYYAILAAGATVVPVHLLLTADEAEFVLRDSGATLLICHPQVESVGAEAARRAGIACLRPESPVGEAIALFVPRSPLDTAVVFYTSGTTGRPKGAELSHLNMVMCATVNAFDANDVHRDDIALGALPLFHVFGQTVSMNSTWRVGATLVLMPRFTAPEAIRLMVTERVNTFHGVPTMYHGLIEAAPDAGELPALRLCISGGAALPLPVLERFEEVFDAQILEGYGLSETSPTAAVNQPVFGPRAGTVGHPVWGVDVEIADPGITDRIELLPTGSVGEVVVRGHNVFSGYTGNPEASGRAVVDGWFRTGDLGVRDEQGYLRIVDRIKEMIIRGGFNVYPTEVEEALLRHPKIAQVAVIGVPDENYGEEIVAVVVPAGEISAEEVIAYGREHVARYKYPRRVEFVSELPLGPTHKVLKRELKQRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5L9</accession>
    <name>A0A231H5L9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin-binding protein PbpB</fullName>
            <ecNumber evidence="6">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pbpB</name>
        <name evidence="6" type="ORF">B7C42_03683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44125">
        <property type="protein sequence ID" value="OXR44125"/>
        <property type="gene ID" value="B7C42_03683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="93"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="300"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="640" mass="68124" checksum="F7B951C11F0CF79E" modified="2017-10-25" version="1">MTGRGGGRTGGGATGRGRAGMRSTPARPRRTPRPRAGSPADASTRLRFGVGRVLMLVALLVVAMQLLWLQTFSAPNLSAEAASQRTVHQTDWAQRGAILDRDGRALAFTVVTKKLNFRPIAVRKDLADARAKSDKAPEVDKRLEAIARTIHEKLGKDAPPEAELLAKLRSDDQFTYLAYNVDSRVADEITEKFPEVGTERQDTPVYPGGALAANVVGATGWDGHGQVGLEASMDATLAGTDGSHTYDRGSDGAVIPGSERDKVPAVNGSNVELTLDSDLQYYVQQQVQEAKDKSGAQDASAVVLDAHTGQVLAMANDNTFNPAQDPKFWASADIGNPSVTNAYEPGSVNKIITAAASIEYGLTNPDEVHQVPGEIHMGGVVVHDAWSHGVMPYTTTGIFGKSSNVGTLMLAQRVGEDRFADMVKRFGLGQRTGVGLPGESGGIVPPRDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRIPPRIVKDVIGPDGHRTSEPQPDGVRVVSPQTASTLRQMFQAVVQRDPMGYQQGTGAPAAIEGYQIAGKTGTAQQIDQKCQCYSADRYWITFAGIAPADNPRYVIGIMLNAPVRSTDGSGGQSAAPLFHSIASWALQRDRVPPSTVPPKQLVLQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5P4</accession>
    <name>A0A231H5P4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetracycline repressor protein class E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tetR_8</name>
        <name evidence="9" type="ORF">B7C42_03741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777484.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44181">
        <property type="protein sequence ID" value="OXR44181"/>
        <property type="gene ID" value="B7C42_03741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="21370" checksum="3A540A4665B82E38" modified="2017-10-25" version="1">MQLHRADVIDGAIAILDQYGLADLTMRRLATALHVQPGALYWHFPNKQALLGAVADRILTPMEEPVAAEDWPGQISELAHRLRSCLLAYRDGAEVVSATYASRLTTSKGRERLASAMIRGGMTREEADLAAYTLLYYVLGETVDEQSRMQMDSAGALAEEDSPLYENTSATERFDFGLQLFVGGVLHLLGSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5S5</accession>
    <name>A0A231H5S5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine transport ATP-binding protein ArtM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">artM_1</name>
        <name evidence="5" type="ORF">B7C42_03800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44239">
        <property type="protein sequence ID" value="OXR44239"/>
        <property type="gene ID" value="B7C42_03800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="28722" checksum="34E7B7D6301BB397" modified="2017-10-25" version="1">MSSATAASADVPMIRAERVCKNFGALQVLQGVSLEVARGQVMCLIGPSGSGKSTFLRCINHLERVNAGRLYVDGDLVGYRERGGKLYELRPRESARQRRDVGMVFQHFNLFPHRTALANVVEAPIHVKKISRSQAVARARELLDRVGLADKADAYPAQLSGGQQQRVAIARALAMDPKLMLFDEPTSALDPELVGEVLTVMRELAQSGMTMVVVTHEMGFAREVADQLVFMDGGVVVEAGNPREMLANPQHERTQAFLSRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5X4</accession>
    <name>A0A231H5X4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="5">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kasB</name>
        <name evidence="5" type="ORF">B7C42_03822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44261">
        <property type="protein sequence ID" value="OXR44261"/>
        <property type="gene ID" value="B7C42_03822"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="22"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="42459" checksum="EF25F4DA5433ACCA" modified="2017-10-25" version="1">MPNTTPISIREYQDRMPIAGIGVVSGYGWGRETLWRGLHTGKAAARLYPGYGLDRDEYAWVALVPDGGDESLSPSRYARAVHEAAREAIADATERGWRPGGTVGVIHAIVLGDVRDWEDFYLTDNSRRRSRDYLRLLPSTPISLLMQEFGFHGPSMNVSAACSSANVALITAQMWLDQGFADDVVCVTTDLSASPDMVHHFVQMGAAVIDADPLEACRPFQEGSRGFSFGEASVAFVVSRQVERPYCAMLGGAMTNDAYHVVSVDPGLERILDCTHRALDRAGVRPGDVSYYNAHGPGTRQCDVAERAVLARIFDDRPQVYSIKPLTGHCMGAAAGVEIAATALGYERGVVVAPPIVAEAHPRLLDGPTPFDGGFTVKTSLGMGGHNSVVVLGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H664</accession>
    <name>A0A231H664_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ORF">B7C42_03858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44297">
        <property type="protein sequence ID" value="OXR44297"/>
        <property type="gene ID" value="B7C42_03858"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023466226" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023466225" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="201"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="41279" checksum="8513B2FA183EA751" modified="2017-10-25" version="1">MTDTDIAGGKLVRTQGVTAPLGYRAAGIAAGIKANGKLDLALVFNEGPDYAAAGVFTRNKVKAAPVLWSQQVLTSGRLRAVILNSGGANACTGPGGFQDTHATAEELAKALSNWGTETGAGEIAVCSTGLIGDRLPMDKLLPGVTEIVHEMAGGLSGGTDAAHAIMTTDTVPKQAAFHHADKWNVGAMAKGAGMLAPSLATMLVVVTTDAAATPQQLDTALRNATRLTFDRLDVDGSCSTNDTVLLLANGASGVTPSQEELDAAVLAVCDDLAAQLMADAEGVTKRVEITVTGAVSEDEALTAARAVARDSLVKTAFFGSDPNWGRVLAAVGIAPIELDPDRVTVSFNGNPVCVNGTGAPGAREVDLSGPDIAVLVELGLGEGTATVRTTDLSHGYVEENSAYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6C1</accession>
    <name>A0A231H6C1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gadB</name>
        <name evidence="8" type="ORF">B7C42_03363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44573">
        <property type="protein sequence ID" value="OXR44573"/>
        <property type="gene ID" value="B7C42_03363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="481" mass="53128" checksum="EEE41BFDF2227A17" modified="2017-10-25" version="1">MSASSESDDLFAMPDLDRGAPKHHFPHREMPGPEAYQIVHDELMLDGVSRMNLATFCTTWIDDNARRLMAQSVAKNIVDKDEYPQTAELERRCARMVADLWHCPDPGSTRGTSTIGSSEAAMLGGLAAKTRWRKNGGQGIPNFVCGPVQVCWEKFARYFDVEIRQVPLRGNKYMLEPDDIAAHCDSNTIMVVATMGQTFTGLFEDVAAMSAALDDLEARTGLDIPLHVDAASGGFLAPFTAPDLVWDFRLARVKSINASGHKTGLAPLGAGWALWRTAADLPDELVFDVDYLGGSMATFNLNFSRPGGQAITQYYDFIRLGRTGYTRLQSAIYRVAEHLAHGLTETGLFEMIHDGTPTRGISAVSWRLREDPGFNLYDLSERLRSRGWLIAAYPLPADRQDETIMRAVVRHGFTHDMADLLLADIDRCIDQLKKHPLSTSLTRKEAGGFTHDATAVVSDEAIVTEVQDLRRAAGDDPANIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6E0</accession>
    <name>A0A231H6E0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777633.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44286">
        <property type="protein sequence ID" value="OXR44286"/>
        <property type="gene ID" value="B7C42_03847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7243" checksum="A1F56A367117FC5E" modified="2017-10-25" version="1">MSVDLSGAQWFKSSRSSSQKECVEVAHLSEGMVGVRDSKNPTGPALVFAPAEWDAFTARLESGGLDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6N7</accession>
    <name>A0A231H6N7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041826.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44386">
        <property type="protein sequence ID" value="OXR44386"/>
        <property type="gene ID" value="B7C42_03175"/>
    </dbReference>
    <dbReference type="GeneID" id="66718517"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011312660" description="YkuD domain-containing protein" evidence="3">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="18258" checksum="A53D97B550EDEEAB" modified="2017-10-25" version="1">MNCTSITRWTIRAAAATAIAAAGFAVTVPAGADPVWPGGPDIPGIPQLVPSPPGQISAPCSAAARACLRLSTNEGWLMDNGRVVYGPTPISHGRPGYETPPGTFHVAFKEPYHWSTMHNAEMRWAVFFNGDIATHIGPIEEQSHGCIRMTPEGAKAFYDYVNPGDVFEVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H731</accession>
    <name>A0A231H731_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44734">
        <property type="protein sequence ID" value="OXR44734"/>
        <property type="gene ID" value="B7C42_03529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="35501" checksum="DBB151B65D1C20D4" modified="2017-10-25" version="1">MAATATVSIRASTTVGSPDARISLGPMSLPVPIGVSVWPRPDAANDVDEVLRLATAAQHTGVRSVWFGQKFDLDALTLAAVVGLAVPEIGVGTSVVPINPRHPLVVASQAQTAQAASGGRFRLGIGLGAPPLESAAFGIREDKPVRRLREYLIALRQAIEDGTVDVQGERVYARPPIPTTVHGGGDIPLLVAAMGPLALRATGEAGDGVLPFLAGPRTLESHIVPTLQRVRPANPVRPLQVVAGVVAVVTDRADEVRETAAQALGFYEQFDSYRAVLDREGVAHAVDVALIGDEEYVARGLRAYVDAGATELLIHQTDLAGEDDQLRTWKLLAELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7B1</accession>
    <name>A0A231H7B1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enterobactin exporter EntS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">entS_1</name>
        <name evidence="7" type="ORF">B7C42_03464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44670">
        <property type="protein sequence ID" value="OXR44670"/>
        <property type="gene ID" value="B7C42_03464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="229"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="459" mass="47670" checksum="9C9E71927EA234D7" modified="2017-10-25" version="1">MPESRIGGYRLYSWDDFSKTPRHGESPAVVKVLADVAPLRDIDFRRLWVTNIVTVIGAQLSVVAVPQQIYQITGSSGYVGLAGIFGLVPLIVFGLWGGAVADVMDRRTLLLITSTGTGLTSVAFWLQAAAGVNNVWLVLGLFAVQQAFFAMNQPTRAAIIPRLLPGDLLPAANSLNMTVMQFGAIAGPVLAGALIPVTGLSMLYLLDSIALLATLWAVWRLPAVPPTGVARKAGLSTVVEGFSYLSTQPILLASFAVDIIAMVFGMPRALFPQMAHDTFGDPVTGGVALGLLFAAMSAGAVAGGVFSGWLGHVRRQGMAVVVCIALWGVAMIGFGLAVGATGHQLSVGVGLWIALACLAFGGAVDMFSAALRTSMLQEVATDEMRGRLQGVFTVVVAGGPRIGDVAHGFTAAAMGTAVAAAGGGVLVVIGVLIAAAVFPAFVRYRVPRVHAEIPADQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7H8</accession>
    <name>A0A231H7H8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513337.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44740">
        <property type="protein sequence ID" value="OXR44740"/>
        <property type="gene ID" value="B7C42_03535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="130" mass="14131" checksum="BA0E380770463FCD" modified="2017-10-25" version="1">MSLDVPAALLERAESGPVSDEEFVECVRTSLPYAYEVVSRVAADLRSGTAEFADNQVPPPDETARGQLLRAMASDSIRGSLERHFGIKLAFQNCHRVAAFPLSAVGGDTYSTFISTRAQLLNQSPELRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7T5</accession>
    <name>A0A231H7T5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator ZntR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">zntR_1</name>
        <name evidence="2" type="ORF">B7C42_02864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44908">
        <property type="protein sequence ID" value="OXR44908"/>
        <property type="gene ID" value="B7C42_02864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="13710" checksum="EA04DD01DE039B21" modified="2017-10-25" version="1">MLIGELANTTGVSTRLLRYYEEQGLLSARRDGNGYRVYADDAPQRVHRIRELLAAGLPSSAIRELLPCATATGLQHCDHTRKIMREGLSHLDAQIAELTRRRTLLARQDEQLVAAPYRSDGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H839</accession>
    <name>A0A231H839_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44917">
        <property type="protein sequence ID" value="OXR44917"/>
        <property type="gene ID" value="B7C42_02873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="32168" checksum="A1C6B0F07F89885F" modified="2017-10-25" version="1">MSDTRTDAVPERTAVPDQTAVRVALWRALHVRLDPPPHVLDDEIGLRLADPPEGWRERGDMDPVGTSRFRASIVVRSRFVEDLLTEQAGRVGQYVLLGAGLETFAQRKPEVASRFRIFEVDQPQTQEWKRRRLVEAGYELPDWLRSVPVDFEKDSWWERLTAAGFDPARPALVASLGVSMYLTDAANRETLSLLAASAPGSTVVMSFMPPLELLDEQDRTSREFAESGAAASGTPFRSFYAPAQIVAMAREAGFAQAHHISADELNSRYFAGRPDGLRTSNGEELLVATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8A7</accession>
    <name>A0A231H8A7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44966">
        <property type="protein sequence ID" value="OXR44966"/>
        <property type="gene ID" value="B7C42_02923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15792" checksum="4D579718EF8F4C26" modified="2017-10-25" version="1">MTSDSKTVVQAAWRAFASHDAEQIAAFFTPDAEWLAPAGNATAIALDGPNHMVGREAITQFIADDFPRLFVADVALDFHGFYAEGDRVIVEETMSATLANGNRYSNDYCFIFELRDGVIHRVREYMDTARGHRAVFGEPAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8S0</accession>
    <name>A0A231H8S0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="8">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nuoF_1</name>
        <name evidence="8" type="ORF">B7C42_03083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45126">
        <property type="protein sequence ID" value="OXR45126"/>
        <property type="gene ID" value="B7C42_03083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_51K" evidence="6">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="NADH_4Fe-4S" evidence="7">
        <location>
            <begin position="264"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="363" mass="38388" checksum="94F77018DF84FF21" modified="2017-10-25" version="1">MIGLPEMLAAAGLRGRGGANFPAAAKLELAARHRAELIVNACDGEWDSAKDAWVVAHHLPEVLDGARRITSQRVRMAAHRGSRTLAVLEAAGVDTLAVPRRYVSSEESALVRLAHGGPARPVMRFEPITAGGRDPRGRRLAPTLVLNVETVWRIQQIAEYGPGWFRSYGTADEPGPRLVTVADGVRAPGVHAAEAGLPVSEILDRAGGLATSPLALWVNGLSGGFLPAEARHTLWSRSALAPFGIGPGVGTFRVLAAGSDPWQVVLSALTYAAGESAGQCGPCMFGLPALRDDLSDLLARRAPAETAERLLRRLTRVPGRGACRFPDGVARFLASALDVFGTSLLVESLGSERFSAHKDESCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H928</accession>
    <name>A0A231H928_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator SlyA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">slyA_3</name>
        <name evidence="2" type="ORF">B7C42_02361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45236">
        <property type="protein sequence ID" value="OXR45236"/>
        <property type="gene ID" value="B7C42_02361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="19127" checksum="70B668AB0244FADC" modified="2017-10-25" version="1">MPRSEGSPESVVDADYIVELERALTRIAHLLTRARRHDRTVAAAGVNLDRANVPLLRMLADAAEPMRMGELAACLDVEAPHVTRQIQRLERAGYVDRVTDPEDRRAQRVRITDEGRATVDAIRAVSRRHMRDALAQWSTEDLRQLAALNHRMVDAFLDNAERTDAWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9M6</accession>
    <name>A0A231H9M6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">rpsC</name>
        <name evidence="13" type="ORF">B7C42_02674</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776445.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45549">
        <property type="protein sequence ID" value="OXR45549"/>
        <property type="gene ID" value="B7C42_02674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR45549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="29572" checksum="2B929BF47A3AB594" modified="2017-10-25" version="1">MGQKINPHGFRLGITTDWKSRWYADKQYKEYVKEDVAIRKLLSTGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRAELEKLTGKQVQLNILEVKNPESDAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRSPNVKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGLYEARTTFGRIGVKVWIYKGDIVGGKREVTAAAAQPERRERRERPSRPRRSGSAGTTATSTEAGRAATAVAEAPAENQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9W0</accession>
    <name>A0A231H9W0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45744">
        <property type="protein sequence ID" value="OXR45744"/>
        <property type="gene ID" value="B7C42_02036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="165"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31705" checksum="8A975795E6B000C8" modified="2017-10-25" version="1">MTEHSAVPQRHIDRPIVAAVDGSAVGYHAAAWAAADAALRDCRLHLVTSISVAGGLGPAPILTEDDMSWLHVDAERILVEAARIARAATPDRTPVITTEITTDAVIGHLIAQSDQAEGIVVGSRGLGAIRRGLLGSVSSAVIRHANCPVTVVHSMSATDAVTAVKPVLVGVDGTANSMPALEFAFAEASRRTVGLVVLHAWSDRSSGLDPAIVGWDAIRESEDAVLAETLAGYSERYPDVKVRREMVLDRPVRSLLDASENAQLVVVGSHGRGGFTGMLLGSTSAALVQSVECPITVVRQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Y1</accession>
    <name>A0A231H9Y1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">tgs1_1</name>
        <name evidence="14" type="ORF">B7C42_02056</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45764">
        <property type="protein sequence ID" value="OXR45764"/>
        <property type="gene ID" value="B7C42_02056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="293"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR45764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="445" mass="48684" checksum="C33EA569623157C6" modified="2017-10-25" version="1">MSEFGPLDTGFMELEDSDRHVNIAIAAIAIVAGPVPSRERFDETVTRALGRNERLRQRMRRTPLDITAPSWEGDRDFRLSRHVRWAALPGPRDEGALRELVGEELARRLDREHPLWQVVVVDNLVGDRWAVIVKAHHSMVDGIAGITVFEGLCDEEPESPSELPVRPPDTAASLRATAETVLRLPYTASRFAVRTARTLVPVLRDTVVPTPTSSLNGPLGRRRRYAVARTSLAQLHEVGAAFDATVNDVAVSTLAGAYRRLLSARGEEPQADSVRIVIPVSMRSAEAKYAMDNRVSVVIAALPVDVTDPVHRLHTVHERIARHRARGEAEAEASLLTLAGRLPAGVAAWAFRLATRFPQRGISALATNVPGPRHRLSIAGGEVEQIWPGIPVAMRLRTTVAMLSYAGQFTFGITGDYDTTPDIELIPAAVTDEIETLLARARATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA21</accession>
    <name>A0A231HA21_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA:acetate CoA-transferase</fullName>
            <ecNumber evidence="3">2.8.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.18" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45803">
        <property type="protein sequence ID" value="OXR45803"/>
        <property type="gene ID" value="B7C42_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="264"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="423" mass="43846" checksum="60EE211E7EC872B2" modified="2017-10-25" version="1">MTVVRDPADLDLSEFLRPGDHLVIGQACGEPPTLVESLVRQGAGIGGLTVFIATSFSGSFTPAATAGLRMRSMGAIGALRGLTASHVLEVIACHVGRIGPMLESGALRCDCAFVQVAPADRHGNHSLGLVSDHVAAAVRAARVVVAEINEQVPWTYGESIPGSEIDYAVEVSRPPVTVAPTRIGPVDEAIARHAAAFIGDGAVVQTGIGAVPDALLRMLSDRVDLGVHSGMIGDGLVDLVEAGAITNARKRIDTGVSVTGALIGTRRLYDFADRNPAIRMCPATYTHDAAVLARLDDLVSINSAVEVDLTGQVNAEQHGTAYLGGTGGQVDFVRGAARARGGHAIIALPATAKGGTVSRISAALSGPVTTARSETDIVVTEFGAAELAGRTLAERARRLTAIAHPDFREDLERAAAEITKRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAA3</accession>
    <name>A0A231HAA3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fluoroacetate dehalogenase</fullName>
            <ecNumber evidence="2">3.8.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45884">
        <property type="protein sequence ID" value="OXR45884"/>
        <property type="gene ID" value="B7C42_02176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018785">
        <property type="term" value="F:haloacetate dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="31729" checksum="83C607C3FC05A193" modified="2017-10-25" version="1">MSAPTVPGFDYDRVPVAEDVALSVAHAGSGTPIVLLHGFPQTHLMWRHVAPALAREHTVLCPDLRGYGDSGKPVAAGPDTYAKRTMAADVIALADHFGFDRFALAGHDRGALVAIRAGLDRPDRISQLAVLDVLPTPDMWDVLNGHTAAVAFHLYLMAQPPGLPERMIRASADDFFGHFLDAWCLHPGAIPDDVRAEYLRACAGAVDSIVADYRASATIDLDHDRADRAAGRRLTMPVTVIQQDWGAALGYDAAGIWHEWAADLDHRTLALGHFMAEEAPDAVVEVITDLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAU7</accession>
    <name>A0A231HAU7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE12</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_01037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781413.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46073">
        <property type="protein sequence ID" value="OXR46073"/>
        <property type="gene ID" value="B7C42_01037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="386" mass="41627" checksum="EF29E4DA3D30793E" modified="2017-10-25" version="1">MSFIETDEQKQLRAAVAKLAAKYNYRDYVSAKARRNEPLDELWDEAGKLGFLGVNLPEEYGGGGAGIYELALVMEELAAQGAGLLLMVVSPAICGTIITKYGTEEQKQYWLTRLADGSSKMVFGITEPDAGSNSHNITTTARRDGGDWILNGRKIFISGVDQAEAVLIVSRTEDSKTGKLKPALFIVPTDTPGFEKNRQEMDIIEPDNQFTLFLDDVRLPGTALVGQEDAAIAQLFAGLNPERIMGAAMAVGMGRYAIDRAVEYARERQVWKTPIAAHQGISHPLAQVKIELELAKLMMQKAAVLYDSGDDFGAAEAANMAKYAAAEASIKALDQSIQTHGGSGLTADIGLAGMLGAARIARVAPVSREMILNFVSQHSLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAX6</accession>
    <name>A0A231HAX6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative FtsW-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rodA_2</name>
        <name evidence="8" type="ORF">B7C42_02282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45989">
        <property type="protein sequence ID" value="OXR45989"/>
        <property type="gene ID" value="B7C42_02282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="454" mass="47767" checksum="B53C24CC843CC885" modified="2017-10-25" version="1">MLCTAAVVVVGIAAWIMSSAAGGDDGRSLQWSLLVFAALTLLAHLAVRQFAAHADPVILPCVVLLNGLGLVLIDRLDRAEAASAAAKGVAAPSSDAAHQLIWTAAGIALFALVLVVVRNHTQPARYAYTCGLAGVVALLIPAVLPARFSEVNGGKSWILFSGFSIQPGEFAKVLLLIFVAAFLVANRDLFGAAGRRVLGFTVPRLRDLGPLLVVTFVSVLVLVYEKNLGFSLLVFGTVLAMVYIATGRASWLLIGVAMFAVGAVVAYHLFAHVRVRVRVWEDPMATYYTNGYQIAQGLFGLGTGGLWGTGLGAGRPQEVPFAKTDFIISTIGEELGLFGLTAVILLFGVITVRGFSAALATRDAFGKLLGGGLAFSVGWQLFVVIGGVTKLIPLTGLTTPFMSYGGSSLLANYVIVALLIRISHDARTQAAPAAPPPAPIAEAMTEHIRRPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB00</accession>
    <name>A0A231HB00_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,4-beta-D-glucan glucohydrolase</fullName>
            <ecNumber evidence="4">3.2.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gghA</name>
        <name evidence="4" type="ORF">B7C42_02302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.74" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR46009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46009">
        <property type="protein sequence ID" value="OXR46009"/>
        <property type="gene ID" value="B7C42_02302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031217">
        <property type="term" value="F:glucan 1,4-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375775" evidence="3">
        <location>
            <begin position="31"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="444" mass="49025" checksum="C735D94D661E5CC4" modified="2017-10-25" version="1">MRNLSRRQAFGLLATGTAAAVAGPAAFAQARPAAPATVPNLGADFLWGVASAGFQCEGHAPDSNWLRYVTTHPDYDRYHDAVDFFTGYRSDIGLAAGLGVGVYRISVEWARVQPRPGEWDEAGFAFYDSVLDTMAAHGIRPMLTLDHWVYPGWAADRGGWAHPAMLDDWLANARTVVRRYASRNPLWVTFNEPAFYIVNETRNGGLSPADVPAMQQRLIQAHNTIYDDIHRAQPGAMVTSNLAYIVGTAEPVVNGPMIDAIAAKLDYVGIDYYYGHTPQDVARLSPDDLDRLWTMPLQPEGVYYALEYYSRRFPGKPLYVVENGMPTENGAPRPDGYTRGDDLRDTVYWLQRAKADGIDVIGYNYWSITDNYEWGSYTPRFGLYTVDVLTDPALTRRPTDAVDAYRAITRAGGVAADYRPTRGPVACSLVDIPGSCADPVTVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBG2</accession>
    <name>A0A231HBG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoniazid-induced protein IniA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iniA_2</name>
        <name evidence="3" type="ORF">B7C42_01117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46152">
        <property type="protein sequence ID" value="OXR46152"/>
        <property type="gene ID" value="B7C42_01117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin_N" evidence="2">
        <location>
            <begin position="55"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="622" mass="67484" checksum="BF5C17173ED73397" modified="2017-10-25" version="1">MSSVVAANTVPEAPASPLSRILAETITAARTADRDDLVGRLEVLAGRIRDPRRRIVVVGLGNQGKSQFVNALLNLDISPVGDDATTGVPIVLAHGPQARAEIVITTPSADERDNRRISVPLSDIHTVRPQSPHGRVARVEIELPNPLLADGIVVIDTPPVGGHATATAAAVLALAPAADAVLVLSDASTELTEPEVDFLRQVRELCPAVALILSKIDLYPHWRQVLQADQAHLERNRLALPIIPVSALLRSHAMRLQDQQLGRESGFGVLFDFLREQVVARDRAAAQRAVALDISSAAEHLALALSSELVALRDPERGAAAIRELRTAKAQAEELHRRTAAWQQTLGDGITDLAGDIDHDLRDRLRAIGRTAEEWVDENDPGRLWDQLEQWLMQTTDTAIGDNLLWTHHRAIHLAERVAEHFLEFGAVDLPAVRSGSELEESRVAGVTLADLEPDLGIGHKLLVGMRGSYGGMVMIGLASTVAGLALINPVSLGAGVLLGGKAFRDDKRERLARKRSEAKMAVRRYLDDVSFEAGKESRDRLHRIHRILRDHFTGIADRSLRSINDSLQAAQDAAGVANAQRAERCAELERQLRVVAELRRHADVMLPPAGASGRHARGAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBN6</accession>
    <name>A0A231HBN6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.345</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pimB_1</name>
        <name evidence="6" type="ORF">B7C42_01221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.345" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46255">
        <property type="protein sequence ID" value="OXR46255"/>
        <property type="gene ID" value="B7C42_01221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043750">
        <property type="term" value="F:phosphatidylinositol alpha-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="48"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="229"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="45170" checksum="B46D0C210287953A" modified="2017-10-25" version="1">MPETGPRERAAMAQPCGPGSGENETRPGADVREVLLLCWRDTGHPQGGGSERYLEQVGAQLAARGVKVTLRTAHYPGAARRERVDGIDVSRAGGRFTVYPRALAAIAAGRLGFGPLRGLRPDAVIDTQNGIPFFARTVSGAPSVVLVHHGHREQWPVAGRVVGRIGWWIESRLSPRVHRRDQYLTVSLPSAEELASLGVDATRIAVVRNGAEPVPAQSPTGAATTRTPYPSIVVLSRLVPHKQIEDALDVVAGLRDRLPGLRLDVIGDGWWADNLKKRAHSSGIADAVDFHGYVDEARKHELLSRAWVQVLPSRKEGWGLAVIEAAQHGVPTIGYRSSRGLTDSIVDGVTGVLVDDSTQLTDTVGELLADPEGRMVMGEKARARAREFSWEQTGNGVSEVLAAAARREFVSGIVTGQTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCF0</accession>
    <name>A0A231HCF0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775062.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46499">
        <property type="protein sequence ID" value="OXR46499"/>
        <property type="gene ID" value="B7C42_01469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011272465" evidence="2">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="10832" checksum="1FC063D531ECC2F8" modified="2017-10-25" version="1">MQTTAKPKNRTRRLVTRVAVAGALVVVPLSALAVPAFADTPANAPGAVAIDRDNHPGDRDHDGDHRGPDGDHRGDNRGDRDRGPENQPAPAPQLPQLPPTGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCW5</accession>
    <name>A0A231HCW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46689">
        <property type="protein sequence ID" value="OXR46689"/>
        <property type="gene ID" value="B7C42_01664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511453" evidence="2">
        <location>
            <begin position="29"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13262" checksum="BEE261A7A9D1F5C9" modified="2017-10-25" version="1">MTNTLARLGVTLAATAAVAAAFAPSATADTISYYTNQSDTVRVPPRTENEGDARCNDGDTATGGGALLEGGYSIDEPYMRVVQNGPVGFSGNAAPPAWRVTYHNEDPEDPHGYVVFVICEHTETTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCZ4</accession>
    <name>A0A231HCZ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trehalose monomycolate exporter MmpL3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mmpL3_2</name>
        <name evidence="10" type="ORF">B7C42_01768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46790">
        <property type="protein sequence ID" value="OXR46790"/>
        <property type="gene ID" value="B7C42_01768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013031317" evidence="8">
        <location>
            <begin position="39"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="211"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="753" mass="78929" checksum="774EB9C7E0DED7F6" modified="2017-10-25" version="1">MLTRIARLATRYPKRVLLAALALALICGGFGATVTAHLQAGGFTSDKAESTRAAQLVADQFNGAQPNLVLLVHADEGVESAAARAVGADIADRLGSRADTVGVRSYWTSPPQLAAALRSTDGKSALVMAYLTGGDDKAQRTAGEIASTLPLSTPGVTVQAGGIAAVYHDVNNQVTKDLAMAEGIAVPLTAIVLILVFGSVIAASLPLAVGIFAILCTLAILRSFTLFTDVSIYALNMTTALGLALAIDYSLFIVSRYREELSAGSSHEAAAVRAVQTAGRTVLFSALTVALALAVLSVFDMYFLKSFAYAGVAVVAAAAIASIVILPAALVLLGDRINSWNLRVAIRKLFGRPEPTSRPERESGWYRTVTWVMRRALPVSVAIIAVLLAVGAPFLGVKFGYPDDRVLPTGSTSRAVGDELRAEFPAVNSGTGTTIVLPGAPSEPQAISGYATALSKVEGVNAVLSSSGVYVSGARMGGAAPGMANDSGQYLTVTSTFDPYSAQAKDQLQALRDVPAPSPALFGGAAAMNVDSLNALGQRLPLAIALIALATFVVLFLFTGSVVLPLKAVVINSLSLTAMFGMMVWIFQEGHFSGLLGFTPTGFLVPTMPILMFCLAFGMSMDYEVFLLSRIREAWLASDRTAADNDRSVAIGVARTGRIITAAALLMAIVLGAMITAKVSFMQMFGLGLTITVLADATVIRMLLVPALMRLMGRGNWWAPKPLARWHERFGLTEHPMSADPQPTAEPAPAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDJ1</accession>
    <name>A0A231HDJ1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diaminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DABA aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ectB_1</name>
        <name evidence="6" type="ORF">B7C42_00141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.6.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778123.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47023">
        <property type="protein sequence ID" value="OXR47023"/>
        <property type="gene ID" value="B7C42_00141"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047307">
        <property type="term" value="F:diaminobutyrate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012773">
        <property type="entry name" value="Ectoine_EctB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552:SF2">
        <property type="entry name" value="PTHR43552:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02407">
        <property type="entry name" value="ectoine_ectB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="418" mass="44781" checksum="0D0F790005CF220B" modified="2017-10-25" version="1">MTTVFETLESDVRGYCRVWPTVFDTARGAWLRDEQGREYLDFFAGAGALNYGHNNPLLKAALIDYIARDGLTHALDMATAAKRELLETLRDLILAPRGLDYKVQFPGPTGANAVEAALKLARKVTGRTTVLNFTNAFHGMTLGALAVTGNAAKRAGAGVPLTHAQPLPYDGYLGDGVDEWVWAERILDDTSSGVDRPAAVIVETVQGEGGVNVAGVQWLRRLSELVAARGILLIVDDVQMGCGRTGPFFSFETAGIVPDIVVLSKSIGGYGLPMALVLMKRELDQWAPGEHNGTFRGNNPAFVTARAALTRYWSDDRLELATLARGERVRRVLAGLADSVGGLSTRGRGLVHGLVFGDASEAGKVSRVAFEEGLLVETSGACDEVVKLLPPLTISDSELDHGLEILARAVDIVCGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE80</accession>
    <name>A0A231HE80_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HEPN_Swt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47122">
        <property type="protein sequence ID" value="OXR47122"/>
        <property type="gene ID" value="B7C42_00244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007555">
        <property type="entry name" value="DUF499"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041650">
        <property type="entry name" value="HEPN_Swt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04465">
        <property type="entry name" value="DUF499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18731">
        <property type="entry name" value="HEPN_Swt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_Swt1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1126" mass="125166" checksum="32B2543B2C088F03" modified="2017-10-25" version="1">MAMNNRDRVGKAFDLLAEGLQDVVDEVMTRVHGSSDWPTKWAEEDARRRGGPLRTFAKHDVQVQLRAITEQGRHFKDVLSRAQQGFASELREGRNLWAHNEPFSSDDAARTLDTIERLLHAVGAVDSAEDVRKLRIDLQRTVFEDQTRKQVKRTKVSLEPSSGLKPWREVIRPHQDVARGEFTASEFAADLYLVHTGQATSPEYGDPVEFFTRTYLTEGLRDLLSRALRRLNGDGNASPVVNLQTNFGGGKTHSMLALYHLFSGTPARSLPQELQELVAANGNPNLDTLGVKRVALVGTYLQAGSPLVKDDGTEVRTLWGELAWQLGGREAYEIVADADRAGTNPGSALRTLIDKYAPALILIDEWVAYARQLVTDKELPSGSFETQFTFAQSLTEIVRSVPGAMLVVSIPASDTSNDGHGADIEIGGANGQLALERLQNVIRRVADQWRPSSKDESFEIVRRRLFQPPNAEGLTTISAVARSFVTLYRNNTALFPRDAASPSDDYEKRIRASYPLHPELLDRLYEDWSTLERFQRTRGVLKLMSSIVHELWASNDASPLILPGNVPLDATTVNTDLTQYLEEQWKPIIDSDIDGPGSTAQQIDLDRPNLGQRFVTQRIARTIFMGAAPRIKSTRKGLDKQYVWLGTAVPGDTLGNFGSAIELLAQRSTYFYEEQGHYWFDTQPSVTKTANDYAERLREDVETVWNEIARRLQSEERSRGVFDRVHVAPASSADIPDLEETRLVIAHPRHTRRKQDGADSATHQWVRGAIETKGASQRTHRNALVFLVADKSEVENLEAATRSYLGWKRVQSTSESLNLSAQQRRQTDDWVERLDQTVADRIRDTFVWALYPEQFDPTKPFELVADKVPDSGGRSLAERVAVKLGREDQLITDFGAAILGATLHQELAALWDDAGEITVGELWGYFTRYTYMPRLVRREVLDAAIQQALTTVLVNSECFGIAVGKDAETGRYRGLVLPPDPKAAIQVTDSTLLLDAKRAQEQLDADRKAAQAAVGETTASDGQVDGTETATTELGGDELAPAESAPAAVLDRFFGSVKIDPHRYSRDIGNVTREVIDRLAGAGARLEITIDIQAIKSEGFDESEVRTLSENARVLKFDPSSGFEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEV5</accession>
    <name>A0A231HEV5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47392">
        <property type="protein sequence ID" value="OXR47392"/>
        <property type="gene ID" value="B7C42_00515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="12081" checksum="DFFAD6502F1AA7D4" modified="2017-10-25" version="1">MTWQDQHARTDILHEVLARAAVDPAMPGLFYDLPECDRLFGGPTGVLAALRYRWDNHLHAKLDQAQLQGQSPSEAYQELAAEQPVLRAVLDAYQVRHWHREPALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEY8</accession>
    <name>A0A231HEY8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47237">
        <property type="protein sequence ID" value="OXR47237"/>
        <property type="gene ID" value="B7C42_00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="20589" checksum="F023655C7B536516" modified="2017-10-25" version="1">MRLRAQELAEAATALLATSPAAAERMLRQAVDSGSGVLSGEQLARLSSLVVTAVANQPGREHDLAAAAVAAAESWAGISAADAAHHTLLAARVHYRSGHHRFAATLFAAALGCDALPYPPEEIAVLYEQFGRCLAQCHRHRAAARAYAVGAAAVAGRPQWDELHGDLIEAATRSRRAARNPAAMVQAYLSARRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF94</accession>
    <name>A0A231HF94_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein KdpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdpE</name>
        <name evidence="5" type="ORF">B7C42_00613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47488">
        <property type="protein sequence ID" value="OXR47488"/>
        <property type="gene ID" value="B7C42_00613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="25679" checksum="12E19D75EECCBA61" modified="2017-10-25" version="1">MTSAERPPAAVRVLVVDDEPQILRALRINLSVRGYEVITAATGAAALRAAAEKHPDVVVLDLGLPDIDGVEVLAGIRGWSSMPVIVLSARTDSSDKVQALDTGADDYVTKPFGMDELLARLRAAVRRSASAAEESAPIVETSSFTVDLAAKKVVRGGRDVHLTPTEWGVLEMLVRNQGKLVGRRELLREVWGPTYATETHYLRVYLAQLRRKLEDDPSQPKHLLTEAGMGYRFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFV7</accession>
    <name>A0A231HFV7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779766.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47565">
        <property type="protein sequence ID" value="OXR47565"/>
        <property type="gene ID" value="B7C42_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022526">
        <property type="entry name" value="F420_Rv3093c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03841">
        <property type="entry name" value="F420_Rv3093c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="35557" checksum="7589B0359479560E" modified="2017-10-25" version="1">MSRYGITLPLPFVPLPRHRGILGELADLGYTDAWTGEYAGVDAFTPLVLAAAWGSPSLRLGTAVVPVYTRGPAVIAQTGAALAELAPGRVVLGIGSSGAQLVTGMNGIAMDEPYRRVRDTLRFLRHAYEHGRVAGRFDTFTIEDFELGRPAEIPPQLMVGALRTGMLRLGFREGAGAITNFLTAEDISTVIRGLGADRDRGELVARIFVCPTEDLDYARESGRRMLTHLFTRPTYGAFHEWLGRGDQVEQVRKHVAAGDLRRAGEAISDDVVDGVLVHGSPERCREQIDRYVEAGVDTPVLMIQSTPELFAGGPEAVLQVVRDLAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG11</accession>
    <name>A0A231HG11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47779">
        <property type="protein sequence ID" value="OXR47779"/>
        <property type="gene ID" value="B7C42_00904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172441" evidence="1">
        <location>
            <begin position="32"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="13508" checksum="3C6C9B165EC2CF05" modified="2017-10-25" version="1">MTGLAHAAHPHLPLVLIGHSLGAGTAVVAMASDAAAVAHICGVVLLGTPEQAPAQGFSTPSVPTLVLHGADDRRAPLAPIRAWTSGALDCRTVEIPDAGHDLLHEPVHRRVTGEIVEFVHARCAAMSGSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSG3</accession>
    <name>A0A231GSG3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000639">
        <property type="protein sequence ID" value="OXR39546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39546">
        <property type="protein sequence ID" value="OXR39546"/>
        <property type="gene ID" value="B7C42_08386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="43" mass="4571" checksum="D87058CD570FD66F" modified="2017-10-25" version="1">MPGKITMNGTNILGKAPMIGARCAAEIELDAIARWTSTKLVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSJ9</accession>
    <name>A0A231GSJ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000608">
        <property type="protein sequence ID" value="OXR39548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39548">
        <property type="protein sequence ID" value="OXR39548"/>
        <property type="gene ID" value="B7C42_08384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="7476" checksum="8DF1C840BE97C01F" modified="2017-10-25" version="1">MLGIAAIGLLVTAVSKARKVGWRALAGRGAGAAGLVLVAVVILWITTLLQTFLGLTGEVKAAHIEAKPVAGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSL9</accession>
    <name>A0A231GSL9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III subunit beta</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaN_3</name>
        <name evidence="1" type="ORF">B7C42_08350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000276">
        <property type="protein sequence ID" value="OXR39582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39582">
        <property type="protein sequence ID" value="OXR39582"/>
        <property type="gene ID" value="B7C42_08350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="59" mass="6265" checksum="5AA5F2B081CFFD02" modified="2017-10-25" version="1">MDGLSALHADRVTFGFTTPSRPAVLLPASEEEPQTLDSGAFAALTGNYTYLLMPVRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSU0</accession>
    <name>A0A231GSU0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000678">
        <property type="protein sequence ID" value="OXR39541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39541">
        <property type="protein sequence ID" value="OXR39541"/>
        <property type="gene ID" value="B7C42_08391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="59" mass="6570" checksum="7E846D8A078A41F1" modified="2017-10-25" version="1">MLLADRVLVLDEGRIAVDLSIEQARPRRHGDPAAAHYREQLLAALGVSTEPTQYEDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSU3</accession>
    <name>A0A231GSU3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000085">
        <property type="protein sequence ID" value="OXR39694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39694">
        <property type="protein sequence ID" value="OXR39694"/>
        <property type="gene ID" value="B7C42_08240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="35" mass="3358" checksum="AB9C04DA681BD520" modified="2017-10-25" version="1">MLSSLSAAAAAMPWGTIAHVVGAMIYAGIGAVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT65</accession>
    <name>A0A231GT65_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000061">
        <property type="protein sequence ID" value="OXR39809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39809">
        <property type="protein sequence ID" value="OXR39809"/>
        <property type="gene ID" value="B7C42_08121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="32693" checksum="86D7C2EAA72CCFDE" modified="2017-10-25" version="1">MTPLETASETADHEPQIYPWKAAPAHLKTRRQFRAAGLAPGGHAPVAQTETRRRGRRLLAYLYDVRLTVPKRTASPAQLAAVAKAVVFHGQDHLLQPGIDQEERPPHLGPAAFDDGGNQHRSSDEIDRGRCPVAAGLRVVVPSGGSAIESRGPGAGERIPARLAIVRPQFRGHLIQADWPQSLCLDVVDHERPSHRVSTSHHVQLPCLFGQRLCRNRMPNPPDTVGALTSDKRGVSAVRGPGSNRAENNEVAWTSSFPELADTTHRACGDCNTHRRMYCLVRGSRASRHARFSIFRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU28</accession>
    <name>A0A231GU28_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40119">
        <property type="protein sequence ID" value="OXR40119"/>
        <property type="gene ID" value="B7C42_07827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="7190" checksum="00F44CAA18E2AFD3" modified="2017-10-25" version="1">MQWQFDLCAGALGNGCLDMDVVVDAPAHRDGAVHGLMGERGVGEAATGPGGDAHPPVAGFDRFQSADHVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU55</accession>
    <name>A0A231GU55_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40160">
        <property type="protein sequence ID" value="OXR40160"/>
        <property type="gene ID" value="B7C42_07742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="224"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="31711" checksum="B5D01417BE0DAA47" modified="2017-10-25" version="1">MSPCRSHNPPRSADSADIVGYAAPSPHAAGPAEAMATRFGRNTLAAADRSRILGAALIDGYDLTESSLPVAEHYHVIAVAIARSEEVTAPRPTAVKRDEDLCGQLASGLAARFGDAAFTMLGTSGGTILLPSDADEQFPDEVVSELSLAVGGAVPVAAVRSSAAAIPRATDLAHDLLDIVLRLGYAPGLYTLADLALEYQLTRPGPGHSSLTAPLEPIFAIPELIDTLRSHIAGNFNRQKTATALKIHRNTVDYRLRRIKDLTGFDPYDHSDLLRLQSALIVHAYHSSDQRPRQLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUC8</accession>
    <name>A0A231GUC8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40234">
        <property type="protein sequence ID" value="OXR40234"/>
        <property type="gene ID" value="B7C42_07659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7061" checksum="01DC826F4AB61303" modified="2017-10-25" version="1">MIVVAGLCYHYLLVMRGVDPVRAVEYLMMIAVPLTAIVLPASSIGAAVRMACQLLGTAFGALGGGGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUF9</accession>
    <name>A0A231GUF9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpD</name>
        <name evidence="13" type="ORF">B7C42_07737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776817.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40222">
        <property type="protein sequence ID" value="OXR40222"/>
        <property type="gene ID" value="B7C42_07737"/>
    </dbReference>
    <dbReference type="GeneID" id="66719302"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="160"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR40222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="52033" checksum="627E924FA4AF04AF" modified="2017-10-25" version="1">MTAAVTQENASRAGAGTGRVVRVNGPVVDVEFPRGAIPDLFNALHADVTLPSVAKTLTLEVAQHLGDNIVRTISMQPTDGLVRGVPVSDTGKPISVPVGDVTKGHVFNALGDCLDTPGLGRDGEQWGIHRQPPAFDQLEGKTEILETGIKVIDLLTPYVKGGKIGLFGGAGVGKTVLIQEMITRIAREFSGTSVFAGVGERTREGTDLHLEMEEMGVLQDTALVFGQMDEPPGTRMRVALSALTMAEYFRDVQGQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGQLQERITSTRGRSITSMQAIYVPADDYTDPAPATTFAHLDATTELSRPISQKGIYPAVDPLTSTSRILEASIVGERHFAVANEVKRILQKYKELQDIIAILGMDELSEEDKVLVGRARRLEKFLGQNFIVAEKFTGQPGSVVPLEQTIDDFERVCKGEFDHLPEQAFNSCGGLDDVEAAAKKIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUQ0</accession>
    <name>A0A231GUQ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40359">
        <property type="protein sequence ID" value="OXR40359"/>
        <property type="gene ID" value="B7C42_07525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012240619" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="374" mass="38433" checksum="FF64F59894D53CAD" modified="2017-10-25" version="1">MFDSRQRTPRHRPAAVAVVLAVSAATWSASGCSASLDRLPLPAPTVAGYSVTATFANALNLPTKAKVRLNGADIGQVESMRAENYTAVVAMRIRSGVLLPAGTTAELRSATPMGDVFVALTPPAHPEPGAPALGDGASIPLRATSAAATIEEVLTKASLLVNGGAIENVTSLANSLGQSVGGRGDRLAAMIRQTRDLVNNLAARSDRIREILATAGDLSAAAAAQRADIDDAMSAAGPALQVVGDNTQQLVDLTGQVNRIAQELGKYPSINGTNDRSMVESVNMLAAGLNAAATDPGADLDNLNTIIPIILKVTDASSAHVTVDVVRLAAGAVADPNTPADSGARPPDGSDWTNFIGSLSYTLNRLKSKVEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUW5</accession>
    <name>A0A231GUW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778595.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40414">
        <property type="protein sequence ID" value="OXR40414"/>
        <property type="gene ID" value="B7C42_07472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="26934" checksum="A6360D902124D278" modified="2017-10-25" version="1">MIVDRFRLDGQVAVVTGAGRGLGAATAVGFAEAGADVVIASRTDSELQVVADRVARAGRRAYAVAADLSDPETNAALAGAAIEQFGRLDIVVNNVGGAMPKPLLDTAVGDLEEAFRFNVSNAHALVAAAVPRILETAGGGSIINVTSTMGRLPGRAFAAYGSVKAALAHYTRLAAMDLCPRIRVNAIAPGSILTSALDAVAADEHVRESLERATPLRRLGDPVDIAATALFLASSAGSFFTGKVLEPDGGLIAPNLEIPVPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV49</accession>
    <name>A0A231GV49_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778562.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40425">
        <property type="protein sequence ID" value="OXR40425"/>
        <property type="gene ID" value="B7C42_07483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="7"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="331" mass="37440" checksum="07B63DFE1A01E4DF" modified="2017-10-25" version="1">MTDIEIIDCHNHILRTAHHSCDLYSNLLRFSAAMGLPDRPGFFGTPDEAEKVMADTGIAHMNILMFTWSGVYWRQGQNILPDDPSERRREEELLRHRIVRRIQDNNTWALGQVAASQRLSCFVGIDPVLMDEQTLLAEIENGRRRGALGVKHVPMNHGTEGDDPRMWPVFDYCASEGIPILTQASGFMAGHPRNYTKALQEFPNLQLIFAHLGHNRQFGQGADAEVLELARAFPGVHTDVSLRLIEVADGHIEPEELVAHLRAIGTDRVLFGSNWVISEYLWFRARPGIVPQSSHERLDRELEVLMTLPLTDDERVNIAAGNFRRLTGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV54</accession>
    <name>A0A231GV54_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40361">
        <property type="protein sequence ID" value="OXR40361"/>
        <property type="gene ID" value="B7C42_07527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="20855" checksum="1E97089BF2215E5B" modified="2017-10-25" version="1">MTSRDWLIGRDRGSEASERIYAAAAELIARDGFDKFSIDALARKIHCSPATIYRHAGGKAAIREVVLTLFSARIVELVRSSIDDLDGTDRIVTAIVVSLERIRSDPLGPMMMHAMMNKHEGEWLIESTIVEGLAQQMLGRPMREPAAAQWLVRVVFALWRWPIKDPDTEYDMIRQFIAPGFSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVH4</accession>
    <name>A0A231GVH4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_22</name>
        <name evidence="3" type="ORF">B7C42_07397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40588">
        <property type="protein sequence ID" value="OXR40588"/>
        <property type="gene ID" value="B7C42_07397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="392"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="474" mass="49486" checksum="5C5D57BD989A9628" modified="2017-10-25" version="1">MSYGSLPLLPSLNPAAVAAGYDIPDAVTIDGETLSRSDLVGAATSVAARVAGAGRVAILARPTATTVLGILGCLIAGVAAVPVPPDAGSAELDHILADSGARAWLGAAPDNPTLPVIPVRKHARSWHSHPEPAANTTAFILYTSGTTGAPKGVVLSRGATAAGLDALFDAWSWTSKDVLVHGLPLFHVHGLILGVLGPLRVGSPLVHTGKPTPAAYAAADGTMYFGVPTVWSRIAEDPDAAKGLANARLLVSGSAPLPVPVFERLRELTGQAPVERYGMSETMITLSTRADGERRPGWVGLPVAGVQTRLRDEAGAPVPHDGESIGGLQVRGPMLFDGYLGLPEATAESWTEDGWFVTGDVAAIDAEGFHRIVGRESVDLIKSGGYRVGAGEVETCLLGHPSVAEVAVVGIEDADLGQRIRAYVVPRPDTAISERELVDFVAQQLSAHKRPREVLMVTELPRNAMGKVQKKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVW6</accession>
    <name>A0A231GVW6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40769">
        <property type="protein sequence ID" value="OXR40769"/>
        <property type="gene ID" value="B7C42_07193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="20219" checksum="279047CC23E46838" modified="2017-10-25" version="1">MGRWEPGARERLVVAAVDLFTEQGYDATTVAQIAERAGVTKSTFFRHFPDKRELLVAGQETLSRLLAEGIAEAPADACPLEAVAAGLERASAAMGPMNRELAPRLKAAVAASAELQERDALKSVGLAAAMTEALITRGVPDATAALASEFGVLAFKRGFAEWSEGEREASDELARHVLSALDELRAASAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF0</accession>
    <name>A0A231GWF0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">hemE</name>
        <name evidence="13" type="ORF">B7C42_06915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40949">
        <property type="protein sequence ID" value="OXR40949"/>
        <property type="gene ID" value="B7C42_06915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR40949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="355" mass="37860" checksum="9E41A3290C6875AB" modified="2017-10-25" version="1">MSTPTRRRLPDAPFLAAATGAGPGRRPVWFMRQAGRSLPEYRELRAGIGMLESCFDPELVCEITMQPVRRHGVDAAILFSDIVVPLKAAGIDLDIVPGVGPVIANPVRSVDDVRALPRLRREEVGAVTDGVRLLLDELGETPLIGFAGAPFTLASYLVEGGPSRHHERTKALMLGDPRTWHALLGVLTDITVEFLRAQITAGVDAVQLFDSWAGALSLAQYREFVLPHSERVFAEIGQAGVPRIHFGVGTGELLGVMGEAGADVVGVDWRVPLTAAARRVGPGKALQGNLDPAVLFAGSEVVDREIRRIAHEADEAITLGATGHIFNLGHGVLPDTDPGAITAAVELIHDLPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWS7</accession>
    <name>A0A231GWS7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alkG_3</name>
        <name evidence="8" type="synonym">alkG_1</name>
        <name evidence="8" type="ORF">B7C42_06793</name>
        <name evidence="9" type="ORF">B7C42_06795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the rubredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41023">
        <property type="protein sequence ID" value="OXR41023"/>
        <property type="gene ID" value="B7C42_06793"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41025">
        <property type="protein sequence ID" value="OXR41025"/>
        <property type="gene ID" value="B7C42_06795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="54" mass="6089" checksum="505496F7991831D4" modified="2017-10-25" version="1">MGAYRCPVCDYVYDEAKGAPREGFPAGTPWESVPDDWCCPDCGVREKIDFEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWS9</accession>
    <name>A0A231GWS9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bmr3_10</name>
        <name evidence="8" type="ORF">B7C42_06829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41059">
        <property type="protein sequence ID" value="OXR41059"/>
        <property type="gene ID" value="B7C42_06829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="594" mass="62110" checksum="66680A8306B2D41B" modified="2017-10-25" version="1">MTTTTTQAAAGTAPDAAGFTHRQVLVFMSGLILGMLLASLDQTIVSTAIRTISDDLSGYSLQAWVTTAYLITATLSTPLYGKLSDMFGRKPFYLAAIAIFVAGSLLCTMAQSMYELAAFRAFQGLGAGGLMSLALTIMGDIVSPRERARYQGYFLAVFGTSSVVGPVLGGLFAGQPAILGIDGWRWVFLVNVPIGLLAFAVVTKVLHLPRRPHPGVRIDWWGVLMLAVGIVPLLVVAEQGREWGWGSPDAIACYLIGVAGVLGFVVVEAKLGDLALIPLRMFKNSTFALGVVISFVVGAGMFGGISLLPQYLQVVRGSSPTVAGLQMLPMVLGMMTASVIAGQTISRTGRYRIFPLIGAGLLTLGLFLLHLIGADSPLWLVMIFMAIAGFGLGNLMQPLTLALQNALPPKDMGVSTAAATFFRQIGGTLGVAVFLSILFAQLTPHISDELHSAATRPAYQQAVIDGAHSSNPADAALSKGLLSHDVSAAGQVMSDSSVIQQLNPTLARPFQVGFADSMDTVFLAVAAIAGIALLLVVFWKEVPLRTAGGLQAGAETSGPRVLVDADSAPVGGEKAEPTATAVRAEPDPAATAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX25</accession>
    <name>A0A231GX25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulatory protein TcrX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tcrX_2</name>
        <name evidence="5" type="ORF">B7C42_06752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41156">
        <property type="protein sequence ID" value="OXR41156"/>
        <property type="gene ID" value="B7C42_06752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="147"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="147"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="27377" checksum="DE5F0165762A8F64" modified="2017-10-25" version="1">MTSTNTPAERVVMRRADGSPVTVLVVDDEPVLAEMVSMALRYEGWQVVTAADGRTAVTAARENRPDVVVLDVMLPDMTGLEVLAKLRRDLPYLPVLLLTAKDSVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGITTVDNDAQIVVGDLMLDEDSHEVTRAGEPITLTSTEFELLRYFMRNPRRVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREPMIHTLRGAGYVLKPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX86</accession>
    <name>A0A231GX86_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NDMA-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.36" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41227">
        <property type="protein sequence ID" value="OXR41227"/>
        <property type="gene ID" value="B7C42_06625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="12"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="38441" checksum="AB26B18FF9BC0CE3" modified="2017-10-25" version="1">MKVTAAVFEAVGRDMTIEELELEDPKAGEVLVRLVASGVCHSDFHVVKGEWEAKGPLVLGHEGAGVVEKIGPGVSTVEVGDHVVLSWVPYCGHCSYCRSGRPALCPQVQETAYANVMADGTSRLSRNGETVYSYLTTGSFADRVVVPASGAVPIRKDAPLDKVALIGCAVATGVGAVTKTANVRPGDSVLIIGCGGVGLSAVMGAALVSAGEIIAVDLSDESLERAKSLGATSTINPGHESVPDRVRAIVGNDGVDWAFEVIGLKPTLEMAYELTRPGGTTVVVGQSADGVTIEIAPMLMSDREKSLIGSNYGSCHPALDFPRLVDLYMRGKLDLDQLISRHATIHDINDAFAAMGARQAGRTIITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXB4</accession>
    <name>A0A231GXB4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid metabolism regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fadR_10</name>
        <name evidence="5" type="ORF">B7C42_06603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41205">
        <property type="protein sequence ID" value="OXR41205"/>
        <property type="gene ID" value="B7C42_06603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="206" mass="22661" checksum="9D326477AD4855E3" modified="2017-10-25" version="1">MKPSKAPSSDAGPDTRRRILDAAVEMAEITGLRKVSMDEIARRARVGRATLYLHFSGRDNLISAMIEDQLGQFFADVQDVLDQHDNSEDRLVHGFAHAFRLLLGNRAVRTVLAVNPEVLYPAIIGDSQPLLLGRLLIESAMGAEDLPAESRSLFAEHVARMFHTYVLIPTQLVDMAAPGVAEDFARQFLLPIRDHLLAAAAEAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXU8</accession>
    <name>A0A231GXU8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Magnesium transporter MgtE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41351">
        <property type="protein sequence ID" value="OXR41351"/>
        <property type="gene ID" value="B7C42_06494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="359"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="465" mass="50455" checksum="2A94D9BA4C9B4016" modified="2017-10-25" version="1">MAATKVFAARLAGLVVLGPDGESIGRLRDVVISIRYDRQQPRVLGLLVELPTRKRIFVPMLRVNAIEPNSVNLNTGTVSLRRFEQRPGEMLALAQVLDSKVRVVDPELPDLEGVDVFVVDLGIEQSRTRDWVLSRVAVRGHRRLGRRREVHVVEWSDVRGLTQHELNLPGQDVTQLLGQFEGLRPADVAHLLRELPEKRRIELARALDDERLADVVQELPENDQVDVLQNLGVERAADLLEAMDPDDAADLLGELPTGEAEALLALMDPEESEPVRRLLEYSPYTAGGMMTPRPVVLTPAATVAEALARIRDPDLTPALASMVFVVRPPTATPTGRYLGCVHTQALLREPPATLVGGLVDSDLTQLHPDAALTAVTRYFATYNLVCGPVVDEENHLLGAVSVDDVLDHLLPEDWREQDEDASEPASTIHSIAAAARAAATGRAATGTAAPGKAETGNAAAGRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY34</accession>
    <name>A0A231GY34_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41506">
        <property type="protein sequence ID" value="OXR41506"/>
        <property type="gene ID" value="B7C42_06398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="24182" checksum="BCFB4708B8270D24" modified="2017-10-25" version="1">MSPQAIRNYDDAGILPPTERTETGYRRYTPRHALALRAFLALRAGHGHRQAAEIMRAIHRGDLESAYRLIDAAHVALLTERETRTEVATALSGLSAAPAPVPGPPLTVGELARRIGVHPATLRTWETHGILRPERDRATGYRRYGPECVRDAEIARQLRRGGYLLPQVAQFLESLRAAGGAAALSVFLAMWQQRLTTRSRHLLAGAAGLDEYLTAVDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYB0</accession>
    <name>A0A231GYB0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783590.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41580">
        <property type="protein sequence ID" value="OXR41580"/>
        <property type="gene ID" value="B7C42_06221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011229375" evidence="2">
        <location>
            <begin position="27"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="229" mass="23825" checksum="36137B75F2AED41A" modified="2017-10-25" version="1">MARLAHFGIVLAAAVGAAVAALPSVAADPPAGAGVHISASADNRKCQVTFKIDNYTNAHNWYTLDYWFSQEDQPWAPPDAEPLPSGWPDPLPSPWRFVPGAKKPVARYTPPSPDDSPGSIRGALPADFPAADRYQAPYTNFNPSALSTPFTTTVTFDLRTVDPAPPTTTDGTYTLRYRVYLGPQTETYGQLVPKSVTVGGCNSGGGSSGSADMGSSGSADMGSSGSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYM1</accession>
    <name>A0A231GYM1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41706">
        <property type="protein sequence ID" value="OXR41706"/>
        <property type="gene ID" value="B7C42_06048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9751" checksum="C37B5CDEA6FE3373" modified="2017-10-25" version="1">MYGSFVNAVIKALAAIPVKPTYLAASSLWMSTLLNHRLGKELPMMPPIDGRMNAAEVWAPESPAAVSEWMKKKCCAPRYPLVTTRFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYN5</accession>
    <name>A0A231GYN5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgi</name>
        <name evidence="9" type="ORF">B7C42_06075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41733">
        <property type="protein sequence ID" value="OXR41733"/>
        <property type="gene ID" value="B7C42_06075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="550" mass="59893" checksum="B707A08B928096BF" modified="2017-10-25" version="1">MSSDITATAAWRKLHDHYSAVADRHLREFFAEDPERGRELTVEVGDLHIDYSKHRITRETLDLLLDLAETAGVTQRRDAMFAGEHINTSEDRAVGHVALRLPPGASMTIDGADAGAQVHEVLRRMGDFTDAVRSGQWRGASGERITTVVNIGIGGSDLGPAMLYQALRHYADAGISARFVSNIDPADLIAKLDGLDPAHTLFVVASKTFSTLETLTNATAARRWLVAALGEDAVAKHFVAVSTHAQRVADFGIDTANMFEFWDWVGGRYSVDSAIGLSMMAVIGKERFAEFLAGMHSVDEHFVSAPPERNAPILLGLLGVWYSNFFGAQSRAVLPYSNDLARFPAYLQQLTMESNGKSVRLDGSPVTTSTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFARPTDDLATRDGSGSMHDILMSNLFAQTKVLAFGRTAAEIEAEDGGTPDFDPALVPHRVMPGNRPSTAILAPQLTPSVVGQLIALYEHQVFVEGTIWGIDSFDQWGVELGKQQALALEPLLTSAEDPAPQSDSSTDALIRWYRGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYS7</accession>
    <name>A0A231GYS7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor SdpR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdpR_3</name>
        <name evidence="3" type="ORF">B7C42_06074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41732">
        <property type="protein sequence ID" value="OXR41732"/>
        <property type="gene ID" value="B7C42_06074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="32071" checksum="CED3468E85CBCB37" modified="2017-10-25" version="1">MLAHPASLTYAGKYLHNFPVRPEPDMDVVFKALADPTRRLLLDRLREQNGQTLRELCERVEMARQSVTQHLDILVRAGLVTVLRHGRERVHYINPAPIHDIEQRWISVFDRPRLDAIRAIRNQAEEYAMSTTVPTYVYVTYIHAGAEQVWKALTDADLTARYWGHANVSDWQPGSSWEHRRVDGSGAVDVVGEVIESDPPHRLVVTFEDMPDADRSPSLVTFLIEPHRDIVRLTVTHENLPNQEMLQGISSGWPAVLANLKSLLETGDVLPQAPWEMSSEPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYU1</accession>
    <name>A0A231GYU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fatty-acid--CoA ligase FadD21</fullName>
            <ecNumber evidence="2">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41777">
        <property type="protein sequence ID" value="OXR41777"/>
        <property type="gene ID" value="B7C42_06119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="543" mass="57513" checksum="FD88CE9C0B5ED199" modified="2017-10-25" version="1">MTGLLDWLAYDGEDRGWTIADEGEWRRVGYPRLSEQVRRVAAACLAAGVRPGAVVSIVESAPERFMTNFFGVLAAGATPNPLAPPLPLQNESAYRQQLSALLAAAAPSAIIVAEELAAVVHPVLESLGGVTIVGTSNETPAVTELPGCEPDRIGLLQFTSGSSGSPKAVRVSVANLEANCAAIDRWLEFRPTDRIATWLPPYHDMGLIGCIITPTILNLDIQAMTPIDFIRDPLSWLSCFGRDGATITATPNFALAYLLRKMTDEALAGMDFDPWRVMIVGAERIDPAILRGFAQRLAPYGFDSRTPCPAYGLAEGTLAVSGLRPSEPVQAAAVTPDTGAVDGPFDLMSAPVEDGRRWLVGCGAPLDGVTVRTASTDEYAGAPGELIVGGPSVAREYQTAEGTRDLSRAEDGALATGDAGLLVGGQLYPIGRVGDAVKVRGRTVYAEDIEAAVVEAFGVPANRVVALAGNAFGSARVAVLVEDKPVEAVRLRQVLAGQLGAETSLRLFIGDRGLIARTTSGKPRRRVMWNQLLQGEFDALERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYX2</accession>
    <name>A0A231GYX2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative succinyl-CoA:3-ketoacid coenzyme A transferase subunit B</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">scoB_2</name>
        <name evidence="3" type="ORF">B7C42_06156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41814">
        <property type="protein sequence ID" value="OXR41814"/>
        <property type="gene ID" value="B7C42_06156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:3-oxoacid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="22845" checksum="68CBD3F584B60592" modified="2017-10-25" version="1">MSGVIARSGWDRSAMAARAARELRSGEYVNLGIGLPTLIPDHLPADIRVTLHSENGILGTGPYPAKSEVDANLINAGKETVTVLPGASFFDSATSFAMIRGGHIDTAILGGMQVSATGDLANWMVPGHMVKGMGGAMDLVHGARRVIVLMEHTDKSGAPKLVSRCTLPLTGVGVVHRVITDLGVLDITASGPVLRECAPGVTEDDVVAATGAPVRIDIGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZB9</accession>
    <name>A0A231GZB9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentachlorophenol 4-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcpB_3</name>
        <name evidence="2" type="ORF">B7C42_05938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.50" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41954">
        <property type="protein sequence ID" value="OXR41954"/>
        <property type="gene ID" value="B7C42_05938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018677">
        <property type="term" value="F:pentachlorophenol monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="14"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="418" mass="44543" checksum="3B04888AA2F3BF67" modified="2017-10-25" version="1">MDPAEQEPGTAETVDVCVVGGGPAGLVAGVLLARSGARVVVLEKHPDFLRDFRGDTVHPSTLTVMDELGLADEFLALPHVRAPRLPMATALGPVVFADFARLPGRFPFVAFMPQWDVLNFLAEAGRRYPGFRLLQRAEVTALLESGGTVTGVRAATPDGPLEVRARLVIAADGRNSLVRTSGALAVAAGRAPMDVLWFRVGKPDGESLPTVRSGKGFFIVCIDRGDYLQVAYMIPKGGFETIRAAGLAAFRAQLAAIYPVLAPVLETAIRDWDDVKPLDVRVDRLRHWCRPGLLAIGDAAHAMSPAGGVGINLAVQDAVAAARLLAPTLAAGGVPSLAQLRAVQRRREFPMRVVQFAQLRLLADLYPNAGGPSTDKPLLARLLRRFPGLSHVVARVIGLGIRPEHVPPAHGDQLVSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZF2</accession>
    <name>A0A231GZF2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-methionine gamma-lyase</fullName>
            <ecNumber evidence="7">4.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mgl</name>
        <name evidence="7" type="ORF">B7C42_05971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41987">
        <property type="protein sequence ID" value="OXR41987"/>
        <property type="gene ID" value="B7C42_05971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="433" mass="46139" checksum="487DD27E45C46C77" modified="2017-10-25" version="1">MSEPPTGRSWSFETRQIHSGAQPDSGTGSRATPIHQTTSYVFRDTDHAAETFALRDPETHAYTRVSNPTTAVAEQRLADLEGGLGAVAVASGQAAVSLALLTIARAGDHIVAAATLYGGTYNLLAHTFADLGITVEFIADPDDAAQWRRAIRPNTKALFAETIGNPLGNVLDVAAVADLAHTAGIPLVVDNTVPTPYLLRPIEHGADIVVHSTTKFLSGHGTAIGGAVVDAGRFDFRADPHRWPQLNSPDPSYHGLVFAAEFGELGYLTRLRTKLLRDLGPAVSPFNSFLLLHGLETLSLRVARHSDNAAAIAEWLSARTEVVRVHYAGLPGSRWHDAARHYLPRGAGGVLAFELTGGAAAGRRLVDRLHLFSHLANIGDVRSLVIHPASTTHAQLDPRQQRDSGVTPGLVRLSVGLESSTDLIADLEEGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZI0</accession>
    <name>A0A231GZI0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SL659 acyltransferase papA1</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">papA1</name>
        <name evidence="2" type="ORF">B7C42_06020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42036">
        <property type="protein sequence ID" value="OXR42036"/>
        <property type="gene ID" value="B7C42_06020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="67"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="474" mass="52402" checksum="59066B6AC0940C52" modified="2017-10-25" version="1">MVGFGFFDDWHPQPGRLIAWAPTAQSRAAVLAAPEHPVGPSYQQREYLRAAYRQRGSGSRASRLCMIAFDFPSALDRDAMTRTITAFARRHDTFWSWFSCEPGERIARHVADPGDIEFELRDYGEITDSDAVRDHVQRHARDVFDWDCFGFGVIDRGDSFTVYAAVDHLHTDGVGQALSCVDLLLLYGNELSGGQVPIEPVDGHLAYCERELSYNAELTTDSAPVQRWLELLIRHDGAVPSFPMDLGVAPGASGFTRGAQITVPLFEEAEALRFEQVCQDFGGKFLGGVFAAIALTEHELTGRDKYFVFTPVNTRSTPGEQGAIGWYTSLVPVAVAVRPDETFTSLVGRAQAQADAAKELAQVCVHRVLELAADDPRIHTRLGFSAPMVSYVDVRRMAGAEMFDRINGGLYGNRASSSEVYLWINRFPDITQLSMVFPDTPRAHEAVAQYLSTLTKLCRDIALTGTERVDAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZS3</accession>
    <name>A0A231GZS3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase-like protein YjlD</fullName>
            <ecNumber evidence="4">1.6.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yjlD_2</name>
        <name evidence="4" type="ORF">B7C42_05712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42113">
        <property type="protein sequence ID" value="OXR42113"/>
        <property type="gene ID" value="B7C42_05712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="43431" checksum="D8B86D7CD81B6759" modified="2017-10-25" version="1">MKHRIVVLGAGYAGAITAGRLAKRLHRDDIEITVVNADPDFVERIRLHQVAAGRDLPVRPLRKIFAGTGVRVRIARVDSVDADRKTVELIDENGAETLAYDTLVYALGSTIADLGVPGVAEHTHNVAGKQAALRLRERLNELVAGETVLIVGGGLTGIEVATEIAESRPDLKVAIAARGGVGDWLDEKAQTHLRAGFERFGITVHEHADVTRVTEGGVVTRTGAEIAARTTVWTAGFAVHPIAAASALTVSESGRIVVDDTLRSVSHPDVYAIGDAAHAAGVGGKTLRMGCATASPMAWLAGDVIAARLTGREVPNAPIGYNSQCISLGRRDAIVQKVTAQDQPTSKVDVGRKATRVKELICKATVWSVNHPTLMMPSRRRHLITPPEPGRRTVGRTTAADRQSTAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0E7</accession>
    <name>A0A231H0E7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_05563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42364">
        <property type="protein sequence ID" value="OXR42364"/>
        <property type="gene ID" value="B7C42_05563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="104"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="345" mass="38497" checksum="E5F1B84A3F099A71" modified="2017-10-25" version="1">MLGVQPETTEIAEPTVPRRVIRYAVRIAYLAALAVALITGALPGGRVQEAAWMIGGVLAFTIDRPWRQHIRVLTDWLPLIAALMVYDYTRDLADKLGMPLRMHELVDIDRWMFGGTVPTIWLQDHLAGDGRPWWTPIIGVVYTTHFILPWAVAAIFYVYSRPLWVRYMRRILLLSYLALVTYVLVPAAPPWYAGREGAIPEHVRRISGFGLGVVDPNVSAQWLEDHGNYVAAVPSLHTAFSVLVAATLWPLTRQWWLRAILVIYPCAMGFTLVYGGEHWVFDVLLGGVYTAVTILLTRIWENWRAGRALLGPLPAVGRGDAAETDRDTESETETVPAAAVPNGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0L4</accession>
    <name>A0A231H0L4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_05500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42301">
        <property type="protein sequence ID" value="OXR42301"/>
        <property type="gene ID" value="B7C42_05500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="25661" checksum="69A5648407DC96A9" modified="2017-10-25" version="1">MTERVSSADPVLGKVSALEHLAEEGLRTLAVKPRMRGWIHTYAVGVAAVAVAVLVAAAATVSATAGWSTLVYGVTVCGIFGISAIYHRVTWQSPRTRIRMKRADHSMIFLFIAGSYTPFALLGLPGSTGITLLSVVWAGAVAGVALKVLWPAAPRWVGVPLYLLLGWAIVPVAATLTHNVGVTPMVLLLIGGIAYSVGAILYAAKWPNPWPEVFGHHEFFHAATVLAALCHYVAIWLVVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0N9</accession>
    <name>A0A231H0N9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">prs</name>
        <name evidence="8" type="ORF">B7C42_05598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515237.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42397">
        <property type="protein sequence ID" value="OXR42397"/>
        <property type="gene ID" value="B7C42_05598"/>
    </dbReference>
    <dbReference type="GeneID" id="66724396"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="234"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="35415" checksum="149A6E1772DC144F" modified="2017-10-25" version="1">MTAFSTDNQKNLMLFSGRAHPELAEQVAKELDVAITPQTAREFANGEIFVRFEESVRGSDAFVLQSFPAPLNQWLMEQLIMIDALKRGSAKRITAVLPFYPYARQDKKHRGREPISARLVADLLKTAGADRIITVDLHTDQIQGFFDGPVDHMHALVQLSEYVRNHYSTENVTIVSPDAGRVKVAEKWADALGGAPVAFIHKTRDPLVPNQVKSHRPVGDVAGRTCILIDDMIDTGGTIAEAVRVLREAGAGDVVIAATHGVLSSPAAERLASCGAKEVIVTNTLPITEDKKFPSLTVLSIAPLLARTIREVFENGSVTGLFNGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0T5</accession>
    <name>A0A231H0T5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780673.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42391">
        <property type="protein sequence ID" value="OXR42391"/>
        <property type="gene ID" value="B7C42_05591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10290" checksum="12EDCFB53D391264" modified="2017-10-25" version="1">MIAAFSVTPLGTGADVGRAVAEAVRIVRASGLPNETNAMFTTLEGEWDEVMGVIKQASDAILAVAPRCSLVIKADIRPGVTGALTSKVETVERYLAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0X8</accession>
    <name>A0A231H0X8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_E_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780728.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42441">
        <property type="protein sequence ID" value="OXR42441"/>
        <property type="gene ID" value="B7C42_05642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="16646" checksum="6E08CB45DE6EC4D8" modified="2017-10-25" version="1">MQFEIVERDETWVAGLPVRSPKRALGELRDRDLEAAWAAVLHQELGGPLASSYTDYAPDLGTFNTQIVGYECTSFDRVTRGHIVSRLPAGAYARFSAVGNFPQIMTDLWTQIAYAEEHNQIKRTFTGDFECYPHAYKIDLYLAVDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Z6</accession>
    <name>A0A231H0Z6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="4">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">mtnC</name>
        <name evidence="5" type="ORF">B7C42_05322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42545">
        <property type="protein sequence ID" value="OXR42545"/>
        <property type="gene ID" value="B7C42_05322"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043715">
        <property type="term" value="F:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043716">
        <property type="term" value="F:2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01681">
        <property type="entry name" value="Salvage_MtnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="26193" checksum="F802561559E1DCAA" modified="2017-10-25" version="1">MSERQSESEALPVRAVVVDIEGTTSPTSSVREDLYGYTRRRLPQWLADEPEGAAKTVIEQTRELAGRPAADLAEIAEILRGWLDSDVKAAPLKTAQGVICAQGFREGALFGEFFPDAPPALRAWHAAGLTLWVYSSGSVRNQQDWFAHARGGELASLIGGWFDLVNAGPKREEQSYRRIAAEIGVPAGEILFLSDHPDELDAAVAAGWQAVGVTRAGEPNSPRPPHRWIGSFAELDPVAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1D9</accession>
    <name>A0A231H1D9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription elongation factor GreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">greA_1</name>
        <name evidence="2" type="ORF">B7C42_05438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505644.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42660">
        <property type="protein sequence ID" value="OXR42660"/>
        <property type="gene ID" value="B7C42_05438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GreA_GreB" evidence="1">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="16279" checksum="57DE22B2D551DD68" modified="2017-10-25" version="1">MTGTESVWLTQDAYERLRRELLELRAAQHGPGDEDGQSAAGRRLRRLELEELLDRAVVGQAPADDGIAEPGMVLTVRFDDEQTETFLLGRRDGADTEELEVYSPESPLGSALTGARPGQVCSYRIPSGASVNVTLLEAVPYGMHLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1T4</accession>
    <name>A0A231H1T4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase YpeA</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ypeA</name>
        <name evidence="2" type="ORF">B7C42_05152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42814">
        <property type="protein sequence ID" value="OXR42814"/>
        <property type="gene ID" value="B7C42_05152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="17401" checksum="A3194E5106EC55AE" modified="2017-10-25" version="1">MIRRATPEDVPALVELVYDLAEYEKAREQCALTAADLHSALFGPAPALFAHVATVDGRVAGCAIWFLNYSTWTGKHGIYLEDLYVRPEARGRGLGRALLAELAREAVANGYTRVDWSVLDWNTPSIEFYRGLGAVAQDEWTGFRLAGDALARLADSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1W3</accession>
    <name>A0A231H1W3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfoX_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780204.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42840">
        <property type="protein sequence ID" value="OXR42840"/>
        <property type="gene ID" value="B7C42_05178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12044" checksum="FDA80B065D4B6587" modified="2017-10-25" version="1">MAYDEELADRIRDLLGPAVTETVEKRMFGGLAFLVGGNMAVAASGQGGLLVRVDPAQAEELIDGSAVAPMVMGGREMRNWLRVAPEYLDDDEALHTWLDRGLGYARTLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H233</accession>
    <name>A0A231H233_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein Stp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">stp_9</name>
        <name evidence="8" type="ORF">B7C42_05231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42892">
        <property type="protein sequence ID" value="OXR42892"/>
        <property type="gene ID" value="B7C42_05231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="38"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="509" mass="51814" checksum="41DB6845F7A2D0B5" modified="2017-10-25" version="1">MGDMMFRHPRRVNQMQTDKADDRSHVPSIDLRRPSPLTLPVVLVGVVLVAMSISGTAVALPSIGEDLAASGSALNWVVAGYNLAFAAMTLVAGSTADRVGRRLVFIGAAMIFAAGSVLAAVSPVIVVADIARIVSGIGGAGIMAAGGAILASSYDGNARNRAFALMGTMAGVGIALGPSLSGVLISLTGWRGSFLLFAAVGLVIAFGATRLDESHADGGRTDLFGSIAFIVSLSAIMFAVIEGPTMGWTDGRVLVAFVAGLILLVVFGLAQRRSPSPVLAPSLVRNRGFLGWSLATLTTSIGFLGALVFLPSYLQAVSGFSPVEAGVAMLLLTAPVLVMPMVAGQLVNAGLSAKALILAALVLVVAGNLALLSLDPDNTITVAAGPLLMIGIGMGTSFGITDAQAMSLVSPDMVGMAAGFLNTLRGAAEALVIAGFSASLLGFLGSKLADPDRAAMVSSGRLSTDPGPEIDAFTWSWHMTQLAIGVLCLALSTLVAFLILPTERSATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2F0</accession>
    <name>A0A231H2F0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase EphD</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ephD_4</name>
        <name evidence="2" type="ORF">B7C42_04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43024">
        <property type="protein sequence ID" value="OXR43024"/>
        <property type="gene ID" value="B7C42_04910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="275" mass="30084" checksum="0DE79E67303CEDCF" modified="2017-10-25" version="1">MDTVAGKRVLITGAAMGLGKSFAQRAVREQAADVVLWDVNETALKQTAAELSSGAVSRVHHYVVDVSDQQSIIEAGAAVRSEVGDIDVLVNNAGIVRGNGYFWETENRADIDKTMAINSLAPMYVALEFLPAMVDRKTPARVLNIASSAALVSNPRMSVYAASKWAALGWSDSVRLELEQSGNEHVKVTTVCPTYINTGMFDGAKGFWFTPILEQEEVVDTAWREMKNGAALVVLPWTSRLNRAISGLLPLRVRDYYLNKVGVYHSMDDFTGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2H9</accession>
    <name>A0A231H2H9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferric enterobactin transport system permease protein FepD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fepD</name>
        <name evidence="8" type="ORF">B7C42_04941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43055">
        <property type="protein sequence ID" value="OXR43055"/>
        <property type="gene ID" value="B7C42_04941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="37148" checksum="D9474156B7DDD51F" modified="2017-10-25" version="1">MSGDGSPRKCPIAMKRVTQESFAAVSAAVITPRRRATGLALLAGVLLLAVVAGLAVGAKSLSPAEIWHAVSCPDGVPFTCPADGQADRIVRELRLPRTVLALLTGAALGIAGALIQGYTRNPLADAGLLGLNAGAAFLAALGIHLFALTQPSQYIWFAFAGALAAGVVVFGAAATGGSRSTPLTLVLAGAAVTALLQALTNAVILLDPAALDTYRFWVVGTPAGHEPAVAAQVAPFILAGAVLAILAAPGLNAIGLGEDVARGLGVNIARNRAIGLTAVVLLTGAATAAVGPIAFLGLVVPHLGRMITGPDHRWLIPYSALLGAIVLLLADVVGRVIAPPGELQAGIVLAAIGAPCFIALVRRRKVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2M7</accession>
    <name>A0A231H2M7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-N-acetylglucosamine deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.104</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pgdA</name>
        <name evidence="2" type="ORF">B7C42_04991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.104" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43105">
        <property type="protein sequence ID" value="OXR43105"/>
        <property type="gene ID" value="B7C42_04991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="47"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="25756" checksum="262D487366266148" modified="2017-10-25" version="1">MKRRLLLGGALVVVLAAVLSIGTYVLMNSRTLQVAGRLVHRVDTAGKVVALTIDDGPTDRTPEILETLAAEHIPATFYLVGRDLAAHRDYGAQIAAAGHELGNHSYTHRRLVFVGPATVRDEVERTDAEIERTGYHGPVTFRPPYGKKLVALPWYLSHHDRTTVMWDVESDSTGGASTDVIVSDTVNRARPGSIILLHAMYQPAAAAAIPRIVAELRSRGYGFVTVSQLIAGTKPTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2V5</accession>
    <name>A0A231H2V5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-dehydroadipyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">paaF_4</name>
        <name evidence="1" type="ORF">B7C42_04615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909005.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43193">
        <property type="protein sequence ID" value="OXR43193"/>
        <property type="gene ID" value="B7C42_04615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="32879" checksum="5910EDD3D6F421C2" modified="2017-10-25" version="1">MSYRYIRYETLEQGRIARITLNRPQARNAQNRGMLVELGEAFERAEADDTVRVVVLCGDGPAFSAGHDLGTAESVAEREPGPDQHPSFQCNGGTLDGAESRLRQEWHYYFENTKRWRQLRKITIAQVHGKVLSAGLMLAWCCDLIVAAEGTVFADVVGTRLGMCGVEYFAHPWEFGPRKAKELLLTGDSIDAEQAYALGMVSKIFPAESVSERTVEFAARIGKVPSMAALLIKDSVNQAQDAQGFSTALDACFTIHQLNHAHWSEISRGETYVGTVDYGLEDWRTASALRPADKHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Y3</accession>
    <name>A0A231H2Y3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,2-epoxyphenylacetyl-CoA isomerase</fullName>
            <ecNumber evidence="2">5.3.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">paaG_2</name>
        <name evidence="2" type="ORF">B7C42_04645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.18" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43223">
        <property type="protein sequence ID" value="OXR43223"/>
        <property type="gene ID" value="B7C42_04645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="28306" checksum="7E0D570F76314E5C" modified="2017-10-25" version="1">MTDALLQKIDGGILTITLNRPEAANAIRPDDRDALIELFAAADADPDIRVVVLRANGKHFCSGADVVKLADGHAKNVKRVTDPMRRIMTGAQRLIAAVLDCGKPVVSVVHGAAAGIGAHLAYASDLVIATEAAYFSESFVKRGLVVDGGGAYLLPRMIGMQRAKELVFFGDKLRASEALGLGVVNRVVAEEDLELVLTELTGRLATAPTSSIALTKRLFNSSLDGDRAAAFLAEAMAQEIQSYSADAKEGVRSFVERRPAEYRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H383</accession>
    <name>A0A231H383_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vitamin D3 dihydroxylase</fullName>
            <ecNumber evidence="5">1.14.15.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.18" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43278">
        <property type="protein sequence ID" value="OXR43278"/>
        <property type="gene ID" value="B7C42_04700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004498">
        <property type="term" value="F:calcidiol 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="45475" checksum="9467010BB10E40E5" modified="2017-10-25" version="1">MTETIVRQPITRSATAPLDPPAEYHELREDKPVHRVRFPNGLEGWLVTRFEEGSAVFGDPRFTARRQRHDTLPGEVGEAGQDAPFDPVFVMMDEPDHSLYRRLLAGRFTPKSIQNRLQPYIDQIVDDHLNAIAAGPATFDFVQRMSLPIPCLVICELLGVPYADRDGFHHATEVMMDVGNPREVRDKGAHWLIAYITELIADKKRTNATGDLLAELIAAQRADASFVTDDQLIGMGVLLLFAGHDTTAAMLGLSTYTLLTHPDQRRYLIEHADEPMKVGSMVEELMRYLTIVQFGLGRVALEDVELGDVVIGQGDLVVVAMNAANRDPRVFTDPDVPDFERKMTRHLAFGYGVHQCLGQNVARAELKTVLPKLFQRFPDLRLAVPADEVPMDVTGTNYGVKELLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3C8</accession>
    <name>A0A231H3C8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranial dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">geoB_3</name>
        <name evidence="5" type="ORF">B7C42_04749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.86" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009509.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43327">
        <property type="protein sequence ID" value="OXR43327"/>
        <property type="gene ID" value="B7C42_04749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="12"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="476" mass="49898" checksum="67A52B0A7E5568F1" modified="2017-10-25" version="1">MKREHFLINGKWRAPSGADVLPTISAATEQQIGQSPVATTADIDVAVQAARDALPAWRDLSPVERAGLMERLSENLQKRTAEIGPIVAQEVGTPLAFAGAANVLGPVSQLRYYASKARDLVIDEERPAFAGRTIVHKEPVGVVGVIVPWNYPIGLIHFKLAPALAAGCTVVVKPSPETALSSYLFADAVYESGFPPGVINVVPGDRVVGEHLVRHDGVDKIAFTGSTAAGRRIGELCGAALKPVTLELGGKSAAVLLEDAPLEAFIASMGVVCMANNGQTCVNNTRILAPASRYDDVVDAVTNAMSGYRVGDPLEAATEVGPVVNSVARDRIEGYIAEGLRAGARITTGGGRPAGREKGWFVSPTVFADVDPGMSIAREEIFGPVLTVLPYEGGDEGAAHAANDSIYGLGGTVWSADVERGRAVARRIDTGTVGVNTYTLDVNSPFGGHKASGLGYELGDEGLAAYFKLTSIYLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3H3</accession>
    <name>A0A231H3H3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43398">
        <property type="protein sequence ID" value="OXR43398"/>
        <property type="gene ID" value="B7C42_04265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="19731" checksum="4962E7FC1FB1CA05" modified="2017-10-25" version="1">MSAAITRLTLISHGMTAAMRSARFPVDEPIDELPRGAASPAAPRADRVLAAPELRASATATLLALCATTEPALGDLDCGVWAGRPMDALDPADLMSWMTDPGYRGHGGEAITDLLDRVRDWLDMVVADRCRIVAITHPAVVRASVLLALAAPPESFWRIDVPPLSATTLHSRGPAWTVRHTANPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3I5</accession>
    <name>A0A231H3I5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adhD_1</name>
        <name evidence="5" type="ORF">B7C42_04748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43326">
        <property type="protein sequence ID" value="OXR43326"/>
        <property type="gene ID" value="B7C42_04748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023921">
        <property type="entry name" value="ADH_Zn_actinomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03989">
        <property type="entry name" value="Rxyl_3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="12"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="370" mass="38150" checksum="39A076CF46C4DFB8" modified="2017-10-25" version="1">MKTTAAVLEGPGKAWEIQQLDLLAPGPGEVLIANRFAGLCHSDAHLKHLGAMGTYPLVGGHEGSGVVEAIGAGVDRVQVGDHVVFSFIPSCGMCRYCATGRSYLCDSGANAGTGLMADGTHRFERDGQGVGGFCALGTFSERMVVSQRSLVKIPQDVPLDVAALLSCGVPTGWGAAVNAAEVAPGDIVVVFGAGGIGINAVQGARHAGASHIIVVDPVLAKREFASELGATRATGDPVEAAAWAQELSAGTGADAVIVSTGVLDAATIGRAIACTGKGGRVAVVGLSDDPMDIAIALPAGAVTYNVLRIQGVLFGQCNPQADIPLFLRLWAQGRLELGRLITRRYRLEEINEGYADQEAGRLIRGLIEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3I7</accession>
    <name>A0A231H3I7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43401">
        <property type="protein sequence ID" value="OXR43401"/>
        <property type="gene ID" value="B7C42_04268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="4">
        <location>
            <begin position="104"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="34428" checksum="F3DC6B8CE1FF4DDE" modified="2017-10-25" version="1">MSGLPRYAAMLATAGALPADSAAWAYEVKFDGIRAIGYVDRDLRLISRNGNDVTAAWPELADLAPAAPPIVVDGEIVAFAADGRTSFSALQPRMHQRNPAMIRALTRSIPATYLIFDLLHIGDRSLIDLPYEQRRRLLEQLGLRGPNWRIPPRLTGTGADVLAESARLGLEGIVCKRLDSPYLPGRRSPLWTKVKNVNDQEIVIVGWRPGAGRRAGRIGSLLMGVHDETGELVYIGNVGTGFTQAMLDDLQARLRPLRRQTPTVAAPVKDAIWVEPELVGEVSFTERTGDGRLRHPSWRGLRPDKTPDEVNAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3V4</accession>
    <name>A0A231H3V4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator YqjI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yqjI</name>
        <name evidence="3" type="ORF">B7C42_04437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43569">
        <property type="protein sequence ID" value="OXR43569"/>
        <property type="gene ID" value="B7C42_04437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="76"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="23991" checksum="64A690A3B56D4972" modified="2017-10-25" version="1">MERMENMDRFGRGRRRGPRPDPQERGGHEQFRRHPRGHGFGPFGPDFGPGFGPGGHVGRGRGRGGRGRRGDVRAAILLLVQERPMHGYELIQQIRERSDDIWRPSPGSIYPALSQLEDEGLVIIEKVAGRKTAKLTDAGAEYVTAHRDELGDPWQDVREGVGDQALDLRELVGQLMGAVGQVARAGTPEQAGKAAEVLTEARRSIYRILADDDTTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3W3</accession>
    <name>A0A231H3W3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43535">
        <property type="protein sequence ID" value="OXR43535"/>
        <property type="gene ID" value="B7C42_04403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045919">
        <property type="entry name" value="DUF6338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19865">
        <property type="entry name" value="DUF6338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="16667" checksum="6DAD7088D3BD83D7" modified="2017-10-25" version="1">MNSWVLRAIVLGALTVVLRTLLGFGMIYSPTNGSWMRILCLIVLVVAGVAWGLIDGRSDRRANPDPERGGADLTMRWLKAGVVGGVGSGLVAWLLDFVPKFDLGDNGLLFELTAGASFIVLMIFIPAMVGVAIGRFLVGRDRRKSESSVPPAAASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3W9</accession>
    <name>A0A231H3W9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ORF">B7C42_04481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43613">
        <property type="protein sequence ID" value="OXR43613"/>
        <property type="gene ID" value="B7C42_04481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8275" checksum="E8D90DB8BEB44577" modified="2017-10-25" version="1">MQMFLDILLVITSVLLVLLVLLHRAKGGGLSSLFGGGVQSNLSGSTVVEKNLDRITIFVGLIWFIAILGIGFEIKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H459</accession>
    <name>A0A231H459_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fmt_2</name>
        <name evidence="8" type="synonym">fmt</name>
        <name evidence="11" type="ORF">B7C42_04440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43572">
        <property type="protein sequence ID" value="OXR43572"/>
        <property type="gene ID" value="B7C42_04440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="32902" checksum="3A67248AB1D2FDB4" modified="2017-10-25" version="1">MRLVFAGTPEPAVPSLRRLIESERHEVVAVVTRPDAVAGRGRKVTRSPIGRLADEYGIPVLTPHKPSEPEFVAALTDLKPDCCPVVAYGALLPRVVLDIPRHGWVNLHFSLLPAWRGAAPVQAAVLAGDEITGASTFRIEEGLDTGPVYGVVTERIGITDTAGSLLERLSISGAQLLESTLDGIEDGTVQAVPQSGEGISYAPKVEADEGHIRWDQPALAVGRRIRAVTPAPGAWTQIDGKRLKLGPVELVEDQLPERVIEVRKSGVYIGTATTAVRLDQVQPQGKRMMAALDWARGARLQPGAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4H2</accession>
    <name>A0A231H4H2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L,D-transpeptidase 5</fullName>
            <ecNumber evidence="6">2.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lprQ</name>
        <name evidence="6" type="ORF">B7C42_03990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43755">
        <property type="protein sequence ID" value="OXR43755"/>
        <property type="gene ID" value="B7C42_03990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="5">
        <location>
            <begin position="56"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="252"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="415" mass="43294" checksum="D72476615CF54C50" modified="2017-10-25" version="1">MNIRGIAGRRAVLAGAGQLAVAALVAGCSGSGGSGSSAPKESGPVAKLTFEPGSGAADVNPVAPVSVTVISGRIDRVALTNPDGKQVTGTLSPDGSSFKVTEPLGYGVTYTWSGTAVGTDNKPVTIESKLTTLAPKQTVPATINIGDGQEVGIAAPIILQFKKHVENKEAVEKALTVTTTPAAEGGWAWLPDENGGSRAHWRPRNYWAPGTTVAFAAKLYGLDLGGGAYGNSDLSSQFTIGRSQIVKGYAPSHRVQVIRDGSTLFDFACSYGEGNEARNVTRSGIHVVTEKYEDFLMSNPPFYTNVRERWAVRISNNGEFIHANPESASAQGNTNVTNGCINLSTGDAQQYFPTAMYGDPVEVTGTSIALSAADGDLYDWTIDWDTWKTMSAIQGEPAPVVSATPVAPGPVRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4J8</accession>
    <name>A0A231H4J8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="4">2.7.1.144</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lacC</name>
        <name evidence="4" type="ORF">B7C42_03947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43712">
        <property type="protein sequence ID" value="OXR43712"/>
        <property type="gene ID" value="B7C42_03947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="11"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="31773" checksum="F778E03C385AF930" modified="2017-10-25" version="1">MILTVTLNPAYDMTYRVENFEPGRAHRVSSVEQRVGGKGINVTRVLNQIGKYSRATGFADHTFSAAAERELPVDFVHALPWVRRTVVISECHDGSATSLWEPGARLTNPDAVDQLLVRVGGLVGEAGGIVVSGSLPGGVRASLPADLARIGIDAGVPVICDVDGLALEAAARVPGVILMPDLDELAALTGAHPATTDEAAAAAAALADAGAAAVIVTRGADGMVAVTPDGAWSAALPEPLSGNPTGAGDAAAAAVIAALAGPDRPEWPAILADAVATSAAAVVMAVAGEIDLSLRQRLLAQVVVEKQADPAGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4U0</accession>
    <name>A0A231H4U0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_9</name>
        <name evidence="5" type="ORF">B7C42_04202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776403.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43963">
        <property type="protein sequence ID" value="OXR43963"/>
        <property type="gene ID" value="B7C42_04202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="26645" checksum="F04A0DB8C1F60EC2" modified="2017-10-25" version="1">MQADVTPALQLSGLYKRFGGPWVVDGVSVVVPPGSFFGLVGPNGAGKTTTLSMAVGLLRPDAGQAHIFGADVWADPVRAKTIVGVLPDGLAVPERLTGRELLTYTGLLRGLPPETVAERAQELLSVLELIEAEHTLVVDYSAGMRKKIGLATALLHGPKLLVLDEPFEAVDPVSASTIRTILQRFVTAGGSVVLSSHVMALVENLCDHLAVIDKGRVVAAGSVAEVRGEGSLEEAFVRLVGGRIGGDEGLSWLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4U4</accession>
    <name>A0A231H4U4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43812">
        <property type="protein sequence ID" value="OXR43812"/>
        <property type="gene ID" value="B7C42_04047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="7738" checksum="CEAE312235737DD7" modified="2017-10-25" version="1">MDLLLAAAHTDPEAAGFILRGVKGIFVAIGSIIAAFICAAIAAAKGRNPFGWGLLGLFFSILTLIVVIVIPSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4V0</accession>
    <name>A0A231H4V0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43973">
        <property type="protein sequence ID" value="OXR43973"/>
        <property type="gene ID" value="B7C42_04212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="21646" checksum="20F72C975B2B7570" modified="2017-10-25" version="1">MSDDVPPVSGPDISRRSRGPMRAVRAGVVTGRRTLTYSALAVLSVLVICGAVVLLFGVNRIFTGLLAGAVAGISLLVALFGRDVVVLTDRAIYRRTPWAESRLEWDRVVAGRFALDERARWSLALDLTGGDEPHDELVLLSIPPVRHPVSNAYEHRKREQVAEIRRILREKRIPVTLLPEIASALHEHWKLAPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4V6</accession>
    <name>A0A231H4V6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pknF_2</name>
        <name evidence="9" type="ORF">B7C42_04124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43885">
        <property type="protein sequence ID" value="OXR43885"/>
        <property type="gene ID" value="B7C42_04124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="672" mass="72737" checksum="A8DFEE38A8ACFE28" modified="2017-10-25" version="1">MAALAIGETFADYLIEGVLGRGGMGTVYLARHPRLPRRVALKLLDREVSADHERRRRFDQEADIVARLEHPGIVRVYDRGADDGHLWISMQYVHGTDAARLDRRALTTERVLRIVTETAAALDYAHSKSVLHRDIKPANLLLEVPEAGRAERTVLTDFGIARLQDADTELTVTGTLTATLAYASPEQLSGEPLDHRCDQYSLACTLFTLLCGRPPYAGTNPGQVVAGHVTKPIPRPTSVRTDLPPALDPVLARAMAKQPHERYGSCTEFVTQVREALSGNGFGVVADVYRAPAPEPASGADSFVPVPQAGSARGRPVVTPPIVPDVSTPSWEAASQPQQHSPGAPAGAARRKVWIRRGAAAAGVVIVLAGAGVAVDRLPGGQSTADRGWGPKYQPIADNFPHVVSARPGETGWLGTRCAVDPTTGDRAAITCENPDRDLRVELVDLEKADAAVEFAADESKHSGDLLARHPGFTDPLDVVLPTPDATGPQDLYTLFPQDVQRSRFVVGLRWTKRAALEVYDRWWRQLPMGIAPPDATPPAEAKVEAPESVPWCHAARTASDVNDDTPGGTESGPDAVLGYEYAQYATRSGSAARQYVVPETTAVPTAETLQTRIAQVPVGTQHCVHVTGGDVPDRFRVQVFERRPDRGFLYHAYTAITTDRDGRVLIREIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H526</accession>
    <name>A0A231H526_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fusA_1</name>
        <name evidence="6" type="synonym">fusA</name>
        <name evidence="8" type="ORF">B7C42_04157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781052.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43918">
        <property type="protein sequence ID" value="OXR43918"/>
        <property type="gene ID" value="B7C42_04157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="10"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="700" mass="76962" checksum="0F145DECFD05579F" modified="2017-10-25" version="1">MAQDVLTDLNKVRNIGIMAHIDAGKTTTTERILFYTGVNYKIGETHDGASTTDWMEQEQERGITITSAAVTCFWNQNQINIIDTPGHVDFTVEVERSLRVLDGAVAVFDGKEGVEPQSEQVWRQADKYDVPRICFVNKMDKLGADFYFTVQTIKDRLGAKPLVIQLPIGAEDTFEGIVDLVEMNAKVWTGETKLGEKYEVTEIPADLKEKAEQYRQELLETVAESDEALLEKFFGGEELSIDEIKGAIRKLTVASELYPVLCGSAFKNKGVQPMLDAVVDYLPSPLDVENVEGHVPGKEDEVITRKPSADEPFAALAFKIAVHPFFGKLTYVRVYSGKVDSGAQVINSTKSKKERLGKLFQMHSNKENPVPSASAGHIYAVIGLKDTTTGDTLCDPQNQIVLESMTFPDPVIEVSIEPKTKSDQEKLGTAIQKLAEEDPTFSVKLDAETGQTVIGGMGELHLDILVDRMKREFKVEANVGKPQVAYRETITKPVEKLEYTHKKQTGGSGQFARVIIGLEPFTGEDGATYEFENKVTGGRVPREYIPSVDAGIQDSMQYGVLAGYPLVNLKATLLDGAYHEVDSSEMAFKIAGSMALKEAARKAGPVILEPLMAVEVITPEDYMGDVIGDLNSRRGQIQAMEERSGARVVKALVPLSEMFGYIGDLRSKTQGRANYSMVFDSYAEVPANVAKEIIAKATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Q6</accession>
    <name>A0A231H5Q6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">sepF</name>
        <name evidence="7" type="ORF">B7C42_03695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500371.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44137">
        <property type="protein sequence ID" value="OXR44137"/>
        <property type="gene ID" value="B7C42_03695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="30161" checksum="1D500296E2BE0C4D" modified="2017-10-25" version="1">MSTLHRFKAYFGMVPLEEYEDDYVDDRGPRGIDDRGPLGADDRGVRRSRFDDDPYDAGRSRFGDDRFADDPGYPEPAYKAPYQPGYTVPRRSEFADESYSDDRYEPLRRPTRIESAPSGRSRGLGGGTPMVRGTTHGALAVDPEAERRMEERRMEERARFEPAPRRTPVFEDGGPLSKITTLRPRTYAEAAIIGERFRDGTPVIMDLVEMSNADARRLVDFAAGLAFALRGSFDKVATKVFLLSPSDVDVSAEERRRIAENGFYNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5U6</accession>
    <name>A0A231H5U6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hisB</name>
        <name evidence="7" type="ORF">B7C42_03768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514645.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44208">
        <property type="protein sequence ID" value="OXR44208"/>
        <property type="gene ID" value="B7C42_03768"/>
    </dbReference>
    <dbReference type="GeneID" id="66721568"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="22795" checksum="12A79628E960FFE5" modified="2017-10-25" version="1">MSTEASMNRTARVERTTRESSIVVELNLDGTGRTDISTGVPFYDHMLTAFGQHGSFDLTVQAKGDIEIEAHHTVEDTAIVIGQALGEALGDKKGIRRFGDCYIPMDETLAHAVVDVSGRPYCVHDGEPERLLHTVIPSAGPGASYSTVLNRHVFESIALNARIALHVRVLYGRDQHHITEAEFKAVARALRAAVEPDPRVTGVPSTKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H671</accession>
    <name>A0A231H671_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative TrmH family tRNA/rRNA methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44272">
        <property type="protein sequence ID" value="OXR44272"/>
        <property type="gene ID" value="B7C42_03833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="3">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="31375" checksum="9EC89454DA716CDA" modified="2017-10-25" version="1">MTNTSKRPAERGSDDRTNPELSERNPRVVSAVKLHRSASRRKTGLFLAEGANSVAAALDTERVEELFYSSRAAEREHELVATAAALGVRTSLVSERAAEHLGETVTPPGLVAVCRLVDVPLGQVLSGTASARDAVEGAAASARMLAVPVEMSDPGNAGTLIRVADAVGANGVVLAGDSVDPHNGKCVRACAGSLFHVPIARDRDIDAVLTTLRDNGITVLATTARGEVDLDDADELLRTAGESGGTAWLFGNEAHGLDPAVAARADHRIRIPIHGRAESLNLAAAAAICLYADARVRHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6F3</accession>
    <name>A0A231H6F3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferric nitrobindin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks the conserved His residue that binds heme iron in the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44603">
        <property type="protein sequence ID" value="OXR44603"/>
        <property type="gene ID" value="B7C42_03393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="3">
        <location>
            <begin position="88"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="96"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="26328" checksum="77D47DE2C86A6A6E" modified="2017-10-25" version="1">MTDSASENVENAATNGHASQAHAEGREPDDAARRSADDAARRSGDEAVADAAERAKSTGGRNIPQLPGLPLPEDTANLRLGPDLSASMLALLPLVGVWRGEGEGNDPERGGDYHFGQQIIVSHDGGDYLAWDSRSWVIDAEGNYSGPDLRESGFWRVGIDGDDEVIELLLTHSSGIVELFYGQALTQSSWELATDVVIRSQSGAVVGGAKRLYGIVEGGDLGYVEERVEADGALKPRLSARLQRYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7U7</accession>
    <name>A0A231H7U7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase</fullName>
            <ecNumber evidence="2">4.2.99.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">menH_2</name>
        <name evidence="2" type="ORF">B7C42_02908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.20" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44951">
        <property type="protein sequence ID" value="OXR44951"/>
        <property type="gene ID" value="B7C42_02908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070205">
        <property type="term" value="F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="42100" checksum="7B7119B827423A0D" modified="2017-10-25" version="1">MDVVRARHIARSGVDLHGDEAGDGPTVVLLHAGGERRQVWTPVVERLVEDGLRCVAFDQRGHGDSGGSLRRLDECAGDVAAIVDAEPGCVLVGASLGGLAAVAALGDPRTRAKVTGLVLVDVVPNLDAGRVRRFLDAGGLSDVYPDFIDDVLAHVPGLRQITTHLDIPILLIRAGRGSSLTDVEADGLLQLAPHATVTRIPGAGHLVARDEPEALARTIADLTTPWPALALLRELGAARVEHPGGDLLDHLERVRQLVADLGGGTRVRLAALTHATYGTDGFPHSLLPADRRSRLRAAIGRDAEALVYRYGACDRAETYPHLGATPLPITDRFTGEVVAVDGTDLADFALLTIANELDVVRHAALTTETVHGIRALITACATYVPEAAARALADRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7X2</accession>
    <name>A0A231H7X2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_02991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45034">
        <property type="protein sequence ID" value="OXR45034"/>
        <property type="gene ID" value="B7C42_02991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="PTHR12318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="28230" checksum="9BFB5D8A07D6D45B" modified="2017-10-25" version="1">MLVRDGASGPEVFLQRRVKAMAFAAGMTVFPGGGVDPSDADAEIGWAGPDPTWWGRRFGVDRARAQALVCAAVRETFEECGVLLAGPTADTVVSDTVAYRSAREKLERRELSFGDFLANENLVLRADLLRPWDNWITPVVEPRRYDTYFFVAVLPAGQRADGATTEAHDVAWRTPAQALDRWRAGEDVLLPPTWTQLSSIAEFASTAEILAADRAISPIMPIFEPVDGQPMLQFPNNTRYFADMPDASRLQGSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Y8</accession>
    <name>A0A231H7Y8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fabD_1</name>
        <name evidence="3" type="ORF">B7C42_02858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051024469.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44902">
        <property type="protein sequence ID" value="OXR44902"/>
        <property type="gene ID" value="B7C42_02858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="29498" checksum="5954CC174E310875" modified="2017-10-25" version="1">MLAPWLDLPGARDRLELWSKASGLDLLRLGTTATAEEITDTAVTQPLVVAAALLAFAEIPHEAVPADTIVAGHSVGELAAAAVAGVVSPDDAVKLAAIRGAEMAKACALVPTGMSAVLGGDEAAVLDRLAELDLVPANRNAVGQIVAAGRLDALAELAANPPEKARIRALPVAGAFHTAFMAPAQDAVAEAISQMVPGEPTRTLLSNYDGKPVDSGSDAIEKLAAQVTRPVRWDLCTETVRAAGVSAVAELPPAGTLVGIAKRELKGTPNLALKTPENIPAFVELSATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Z7</accession>
    <name>A0A231H7Z7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoid occlusion factor SlmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">slmA_2</name>
        <name evidence="5" type="ORF">B7C42_02925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44968">
        <property type="protein sequence ID" value="OXR44968"/>
        <property type="gene ID" value="B7C42_02925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21601" checksum="3B89FEB6713AFA28" modified="2017-10-25" version="1">MGNDAEQGGRPLRADARRNRDQVLAVAREMLSIDGSSASFDEIARRAGVGVGTLYRHFPTRSALFEAVVVGRVEEFTERARMLADADSAPEDAFFDYFTHLVGEVALNHALCEALDDGDTAVAIPDRLRHEFIRSFDTLLTRAKEARAVRPEIGVADVLDLVIGAATVERRARARNAPNPLIAVVLDGLRVPDHRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8F0</accession>
    <name>A0A231H8F0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45006">
        <property type="protein sequence ID" value="OXR45006"/>
        <property type="gene ID" value="B7C42_02963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="135"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="35240" checksum="DEC6387D8FE35E00" modified="2017-10-25" version="1">MTETTDLRSDATVLEPATSILDERAAADAPVVHAWMPASPCGAGCVAVPDTAGAVRSVVRVLGVVGLLVAFPVVNVATPPARRTALHRRYARAALRCCGIGLRVVDERGAGAQGAAVDTRPREGDGAAADSGHGLLVVAGHVGWADVLALAAVSPMGFVARGDLVSWPVLGQLARLMRVIPIDRERLRQLPEVIAAMSARLAAGERVAMFPEGTTWCGRAHGRLRPALFQAAVDTATPVQPIRLRYLDHTGETSTVPGFVGVDTFLDSARRVLRAKGVVAELVLLPIEEPGSDRHDLAERCDRAIRGRTEVRIDAHATAIGTGPTREIVVADATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H959</accession>
    <name>A0A231H959_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pknE_1</name>
        <name evidence="7" type="ORF">B7C42_02391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45266">
        <property type="protein sequence ID" value="OXR45266"/>
        <property type="gene ID" value="B7C42_02391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="550" mass="57287" checksum="9415719D79E6B65C" modified="2017-10-25" version="1">MTAREFGRYRLDRLLGRGSAGEVWLAYDPADARTVALKILSGSAAEDADYRRRFEREARIGAHLDNPHIAPIHRFGEYAGRLYLDMAYIPGVDLARLVRSSAMEPAEAVELTSQIAEALDAAHAAGLVHRDVKPANIIVHTSGFAYLIDFGIARAAGQTTITATGFTVGTLAYMAPERFTGHGDSRSDVYSLACVLYECLTARRPFGDTDAVRQLHAHLHEAPPRPSAADAHIPAALDAVVARGMAKRAGDRYRTAGELAAAARAAVGMTIADRTPPLLQSEQGPTTRLGSESATRYISPAPGATGPTFAATRQDAAPAPRGYSSPAPAAYGHPGPAPVTRRVGSEPAGMASDRPPAPVRATRVLPDASAPVGPPAAPADHAVSARPNPPSAGNPRPTLVGSTSLPVKLVPAQHVPAAAPRRPTLVVAAALIGAAILALAVVAGCTALLSSGSRTPSDQPSTTRTEVNTPAPTTAAPATPEPEYTTTVIPPRWTLPFPTNILPPPLPFPHPAAHSEEHHPAPAKKGSPGTPRTDRVSCAEDATACEGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H968</accession>
    <name>A0A231H968_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutarate-semialdehyde dehydrogenase DavD</fullName>
            <ecNumber evidence="3">1.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">davD</name>
        <name evidence="3" type="ORF">B7C42_02688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45563">
        <property type="protein sequence ID" value="OXR45563"/>
        <property type="gene ID" value="B7C42_02688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047949">
        <property type="term" value="F:glutarate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="4"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="490" mass="52631" checksum="568F8305185501A6" modified="2017-10-25" version="1">MAEMLKSHDPRTGELIGEYPILDAAAVTEVVRAARSAETWWAAIGFAGRKRWLLEWKRSIARNAGELAELICTESGKPRVDAAIEIMLAVEHLNWAARNAEKLLGRSKLASTWLTRNQRASVGYLPLGVVGVLGSPNNPVFTPMGSIAYAMAAGNAVVFKPSELTPGVGIWLADSWAALAPNKPVLQVITGTSATSAELCRARVDKIAYAGSEAGAREVIELCAPTLTPVVVEKAGKGTMIVHVDAKLDTAAEAAVFGAMSNAGQSPAGIQRAYVADSVYEPFLERVVARARSLRPGGDRKASYGPMIMDSQVEVVRRQVKDAIARGGRAVVGGLESIREPYIEPIVLTDVPEDSQAITAEAVGPVLIVNRVANIDEAIDRINAADQGLAVSVFTRDVRGVADFAERIRTGVVTVNSTMAYAANPALPFGGVGEYGQGHTHGEAGLREFSRTLAIAEKRYRAPVDLSSFDRHPRHLRLTRAIFRIRHSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9A2</accession>
    <name>A0A231H9A2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_02402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45277">
        <property type="protein sequence ID" value="OXR45277"/>
        <property type="gene ID" value="B7C42_02402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="33546" checksum="523F9F78137EA396" modified="2017-10-25" version="1">MRNSNGLQRRGLAIGCGGTVGAAWIVAALAAVRDVLQWDPREADALIGTSAGAEMVTMLASGISVDDLVAMQRGTVADPILARHMADEPGRFPPLPRPRLGAPRMALHGNRSRQALLSAGSRLLPVGGGDASWLQRLATDLNHDRDWFAHPAAWLVAMDYDSGERVAFGAPEAPAATVGQALRASWAVPGWFPPVPIAGRRFVDGGAASTASVDLLLPLHLDELVVLTPMASARSVPAGGPGHWLERQLRRPMSAQLDSEIAAVRATGTRVLRLAVTAADLAVMGPNFMDGRRRGETFEHSLRSTRRAMERSEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9E1</accession>
    <name>A0A231H9E1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter ATP-binding/permease protein</fullName>
            <ecNumber evidence="13">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B7C42_02547</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45422">
        <property type="protein sequence ID" value="OXR45422"/>
        <property type="gene ID" value="B7C42_02547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="251"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="337"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR45422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="892" mass="94709" checksum="0439C526CAE971ED" modified="2017-10-25" version="1">MSRPSHIIRLMSLPGAQKITVRHEGTDRIFENTQQVTLGRAPEVTVFVDSPLVSRVHATLGWQGGAWVLSDNGSTNGVFVDAQRITRPVPVDRPMLVRLGDAVTGPLVHLLPEAQFRPPAPPNRAQSPGRAPNPPARDAGPRGGQHGGGQHGGGQHGGGQHGGGQQQRRQPSHPTPQSGQLRRPTTPQPPSRPAQRPNQRPSQPIPAAHGSGGVPNVNMTTKADTSALPPVRARASTAPIARADRIPAGGLTIGRTSDNQIVVNDPLASRRHARLVKSGEGLVLEDVGSANGTFVNGRREQRVALRERDIVTIGNVDFVVQEGTLKHRKKPVTEQGLSVHGVGFVVEGNKQLLVDVNMQAGRGTLTALIGPSGAGKSTLSKLIAGTTHPSAGVVTFEGRNLHAEYEAMRSRIGMVPQDDVLHRQLTVRQALGFAAELRLPPDSSKADRQQVIDGVLKELSLTEHADTRVDRLSGGQRKRASVALELLTGPALLLLDEPTSGLDPALDRQVMTMLRELADAGRTVIVVTHSVACLDMCDQVLLLAPGGKTAFCGHPAGVGDFLGTSDWAEIFARVAAEPDRAFANYRSRQAALPPPPPAVPRGVMGQPPKSSGWKQLSTLSRRQVRLILADRGYLAFLVVLPFVLGVLCLVVPGKNGFAAAPPILGPDGQLHPQLTGGSESQQLLVVLILGACFMGSTLTVRDLVGERPIFLRERAVGLLPSAYLLAKVMVFGVAALLQSAVLVAIVLAGKNPPGKGALIPSGGAELYVDIALTAVTCVVVGLLLSTVAKSNEQVMPLLVVMIMCQLVMAGGMIPVTDRVVLEQLSYIFPSRWGFAGGASTIDLRTLFVNAQPDAIWQHTPGFWLLDAGMLIVLTAALSTLTWWRLRLKKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9E8</accession>
    <name>A0A231H9E8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidyl-tRNA hydrolase ArfB</fullName>
            <ecNumber evidence="4">3.1.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arfB</name>
        <name evidence="4" type="ORF">B7C42_01935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784041.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45643">
        <property type="protein sequence ID" value="OXR45643"/>
        <property type="gene ID" value="B7C42_01935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15695" checksum="8FE262D336B4D366" modified="2017-10-25" version="1">MAEDLTVTGMLVIPASELRERFSRSSGPGGQHVNTTDSRVELSFDLANSPSVPEWLRTRMLDRLASRLVNGVLTVAASEERAQLQNRATARDRLASILRDAAAAPPPVRRATKPSRGAKERRIAAKKRRGITKRNRRISPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Q0</accession>
    <name>A0A231H9Q0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783964.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45585">
        <property type="protein sequence ID" value="OXR45585"/>
        <property type="gene ID" value="B7C42_01877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19902" checksum="D7C3B28EB8FD8192" modified="2017-10-25" version="1">MSELTMDQMEEILLAHEKAELEMDIEATMATVSPNCRWEFPTDGLVAEGPEAVREHYRRVLPGAQQWNVAAEKRVHSAGPNALIREAWVSWDTPEGGRANGLYLVVMTFDPEAKLITAERLYADTNFAKYMDRQLDVATYKDFPGVRTLSSVAPVINTHDAFALAESRGITIDGKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9T6</accession>
    <name>A0A231H9T6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783981.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45601">
        <property type="protein sequence ID" value="OXR45601"/>
        <property type="gene ID" value="B7C42_01893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14085" checksum="7500AD78231DE402" modified="2017-10-25" version="1">MTSATELSAGDELPALEVEPISRATLALFAGASGDHNPIHIDLDVARSAGRDDVFAHGMLSMAYLGRLLTDRFPQERIRSWQVRFAAITPVHGRPICTANVVSVADGLATLELTVALEDGTPTLIGDAVVALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9U1</accession>
    <name>A0A231H9U1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dhbF_4</name>
        <name evidence="10" type="ORF">B7C42_02697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45572">
        <property type="protein sequence ID" value="OXR45572"/>
        <property type="gene ID" value="B7C42_02697"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1563"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2671"/>
            <end position="2746"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3633"/>
            <end position="3707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1540"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4586"/>
            <end position="4618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1598"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="4618" mass="487400" checksum="D0FE05747238FAE6" modified="2017-10-25" version="1">[encoded data, 4618 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ7</accession>
    <name>A0A231HAQ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46033">
        <property type="protein sequence ID" value="OXR46033"/>
        <property type="gene ID" value="B7C42_00996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="32977" checksum="08CC74CE7037802D" modified="2017-10-25" version="1">MIENTVTEPGRRRRTIRLLPSIVTILALCAGLSAVKFALDGSLDIALAMIGAAAVLDTLDGRLARMLSATTKIGAELDSLADAISFGVAPALVLYVTFLRQDSAGWIIALIYTVSLVLRLARFNTIMDDDTRPDWEREYFTGVPAPAAALIALLPIALHSQFGEGWWNNFPVVAAWTVFAALLAVSTIPTLAMKSVSVAPQAAALLLVLVALAGAALITYPLILLMVLVGLYLVHMPFAWRSQRWVAARPETWHHKPAERRAQRRAARRMPPIGEGARLRLRRPPGIRESSARLRLRRPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBJ8</accession>
    <name>A0A231HBJ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46228">
        <property type="protein sequence ID" value="OXR46228"/>
        <property type="gene ID" value="B7C42_01194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013076415" evidence="1">
        <location>
            <begin position="26"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="430" mass="46373" checksum="37F4C4AB7A714261" modified="2017-10-25" version="1">MRISAIARGAGLILAAVLGVGALGAAPAVAASDLDRYLDLPLVNRDAARSPGGVHPELPYDHAELGRLLDEARAEGVAPTRYAALLYQYWLVDATEKAGIDLRGWDPRTGVEANRDNLIKSYRYYENLQLGHRELQWAGMGGQVGADFGGGLVDAELMGTLYDLPGIADAAHTVLGAVQRTAGPQAVAMLPDGLRALAEAAPAITPEDLRWILGMILVMQKNIFSDLMPMHDAYVTGGLAALAEFERAGLFGADIMDAWRDVASGAHDRIAAGNAVLLRREQQWAIGAQWDQVRHYKGPVGAAITYLSGAAGSPSVAGVVPPREFRPVRVPFTGADGRPMILGLPLPSWNWSVLDDRWDYITTELLPKYRWQVENNWPALESTLRTPYEAQLESHRPLLNIPQLLNSAAQEMTVTPADPVQAAGGTQDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBS5</accession>
    <name>A0A231HBS5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="3">1.1.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glxR</name>
        <name evidence="3" type="ORF">B7C42_01238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.60" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46272">
        <property type="protein sequence ID" value="OXR46272"/>
        <property type="gene ID" value="B7C42_01238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082149" evidence="1">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="30494" checksum="A5F2A5D4B9E275FC" modified="2017-10-25" version="1">MTANAHTTVAVLGLGPMGRAVATVLTGAGNPTAVWNRTPGKDSELVALGAVSSVDPAAAIDAAELVLTVLSDHSSVHQVLDPVADRLRGKALINLTSTAPDDSRELGRWAAARGIDFLDGGIMAVPPMIGGPGASILYSGSAAVFERFRTDLEKLATAEYFGEDAGTAALLDFALLAGMYAMFTGFFHGTAMVRSAEVTATEFAPRAAAYVTAMAALMPAYAAVIDSGDYTDEAQPARFHKRAFDAIVRASRDAGVALDVVAPIKNLIDRMIADGRAESGLERIVEELAGSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC81</accession>
    <name>A0A231HC81_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysozyme M1</fullName>
            <ecNumber evidence="5">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acm</name>
        <name evidence="5" type="ORF">B7C42_01273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036507005.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46307">
        <property type="protein sequence ID" value="OXR46307"/>
        <property type="gene ID" value="B7C42_01273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011275658" evidence="4">
        <location>
            <begin position="36"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="27287" checksum="97053A2F6722E75C" modified="2017-10-25" version="1">MYRRTVARPKVRRFTAALPLLAVAGIFSATGIASAGPTGPDVSSWQHIDGRLIDWFAVRASGHNFAMVKATEGLNYVNPYFVPDSLLMRAAGVARGTYHYAHPDLPPEPQAALYAAVVLGQNGPLDLPPVLDMENSGGLPPAALIDWTHRYLTTVQALTGRVPIIYTYPRFWQTAMADSDQFHQYPLWIADYRGNAQPEVPGGWPAWTFWQTTDSGSVPGIAGNTDLNVYSGAQGNFAQFANMPFSGSSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCH2</accession>
    <name>A0A231HCH2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775091.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46522">
        <property type="protein sequence ID" value="OXR46522"/>
        <property type="gene ID" value="B7C42_01492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="22016" checksum="DE0FFBE0F5E4DCB0" modified="2017-10-25" version="1">MDASRALLDGLDTTGLNTALAEATCLGLVVDAADGRLRIELEVLTLPGDGQPADGRVSLTLSGVSRVAASLRRQRWDDLEPRIFPLTLDTLGEAIAGFGGGALHGWDFIDVDDSGWALWRELLSFDTTISDRTPAHVLEFSQQEGTDPRELDVRVWFEDITIETADGSLIGLDDFVAGARRWWKAHDSCDPRTMLPDVAPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCJ2</accession>
    <name>A0A231HCJ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46673">
        <property type="protein sequence ID" value="OXR46673"/>
        <property type="gene ID" value="B7C42_01648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="220"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="33092" checksum="D2B43B64DEE1B5F3" modified="2017-10-25" version="1">MTGTTWDTLFGGDVGNIFKGQFGFCLGRDYDANKPLTNFTPFDADGNWSNTLLTTDGFVGLGYFDENGLEFTPTLTTSDTKAWQSRQKLLTDFTADEEAAMFTAIERTPYIEALESNIPFAAMSKMGTIGYQYTKPVNTFPVHRQLIFGSIYMSPQGLSAWARIYSDAIMAKPDKLVMQAKTETQGKLTFDAMLDSVSGFAVRTLREGPGWRARGGTTATPGTPVATAGSAGTASLAFTAPTSANGPFTYQVYVDATPTPVSAGNVTVGGTSTNPVLTVSSVASGSHTFKVQAVGSNGSASNQTPASNSVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCJ6</accession>
    <name>A0A231HCJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactofuranosyl transferase GlfT1</fullName>
            <ecNumber evidence="2">2.4.1.287</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glfT1</name>
        <name evidence="2" type="ORF">B7C42_01581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.287" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051024093.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46610">
        <property type="protein sequence ID" value="OXR46610"/>
        <property type="gene ID" value="B7C42_01581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="34333" checksum="02B2BA13B20E179F" modified="2017-10-25" version="1">MSDQAAPSADSGVARIIAVVVTHKRRELLSESLKVLASQTRPIDHLIVIDNGNEPEVGEMVEEQPIESTYLGSEHNLGGAGGFALGMLHALTMGADWVWLADDDGRPEGPDVLEKLLDCAGRHGLSEVSPVVADIDDPDRLAFPLRRGVVWRRLRSELGDEDFLPGIASLFNGALISAEALEVIGVPDLRLFVRGDEVEVHRRLVRSGLPFGTCLQTAYLHPNGSAEFKPILGGRMHTQYPDDPVKRYFTYRNRGYLMAQPGMRKLLPQEWARFSWFFLVQQKDPAGLREWLRLRRLGRREQFHKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCK7</accession>
    <name>A0A231HCK7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Copper transport protein YcnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycnJ_2</name>
        <name evidence="8" type="ORF">B7C42_01476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46506">
        <property type="protein sequence ID" value="OXR46506"/>
        <property type="gene ID" value="B7C42_01476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="7">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="32617" checksum="E2934F55AB9AA28D" modified="2017-10-25" version="1">MRPGTAGSRSTALRYALLLVVPAALVGVAAGWALAAPDPVQAEAPVRTLADGLGATVLGLAALPRLHDRLRPAWRLLAVFGALWTVAEFVLLSTEAAEVVGVPLSRLRAADFGDYVAHVSGGQIGIAVLIGTVAVACYSTLAFRRPDRASADLVLVFAAVTLVLRPITGHMSQQTLGSVLAAVHALAAAAWFGLLLALALVVRTRGEWAVILPRYSGWALPAVAAVTVTGVVNGLVRVGDPVALVDTGYGRILLAKTVMVLALLGLGWWWRRSWVPVATDHRMSADDSLRRALIEVVVMAAVSGLAATLSVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD39</accession>
    <name>A0A231HD39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46678">
        <property type="protein sequence ID" value="OXR46678"/>
        <property type="gene ID" value="B7C42_01653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="568" mass="61463" checksum="D4ACFEE1F813882F" modified="2017-10-25" version="1">MTLVPIDLANTPDYQAFEQAAARAAEQTQPNGQRQFIVTFYNKWGYPLGECGDYVSVTFTPKRNAISAATIVLKDSDPFVDVAFKARKEVVPCTIELESGWRWSGHVDIPTDDYVAGVGTTTIQLKGDYDWFHALLVFPAWWMPIEAQIPKEAVFIGPAITNIKEMIGEQVLRQSGLLGALLEFAGNILNPAAYIGSLLDVEELALPLVIVPTNPLTDTSKWTAITCKMTTVAAAVEQTLKDCGLLLTADFWRVGDPQPPSLTAWGITLTKPSIVVDVRDYSTVTGLTGTALDGLIGEAISLVDTVLGEILTLLGGADIADSGSTNATNPYGDGILAQLLGLDAKPSWVIYEDGPRSGIQESHIAAHAPLAYRVVTGGKSPDWVNKGIDLLLEWALSALLAAFGASGISSTLLDGLLDNVFLAYMQIEDEQRRIDLGPFGRPEYFAQGGSAAYTLDALVILESALWDTRGYYSFQLVAMDGYPYSFGGDLFGVQYGDFGIGFPVSWIRKGVIYTDYCTEATITDDRTHRVQIIAKVGDQSALESPWARLARRIASLNDIVKAASLAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD98</accession>
    <name>A0A231HD98_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041771.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46766">
        <property type="protein sequence ID" value="OXR46766"/>
        <property type="gene ID" value="B7C42_01744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="44178" checksum="52324106F610E704" modified="2017-10-25" version="1">MSYLPEGFGSFVGEVLTNWTQGRDPSHIQNPYELQGKFNTTRDGVRNDARAIGFEGDFRTPSVQTTDNFERHDLATLREKVDKIDLEAVNNLEDAWNKIGTQETTSLTTFQQAMSKATNEGIWRGQSRNAAAKAVTDYTSQASKVAKAAALTSNKLAELATGLAPTKSLVPHVPSHRSGVSNAVNLVVGKGWRDDVTAYNNAYTEAKRVLTTVYAPVVHESDTGVPVIPKPNTQDPAGPGDQPPPSSWRPGGNGPGPSGPGGTHDTNQPKPGDQNQNGQGSNSQTSQTNPSGNGQSDGSQNAGDQARTDPSSATTPSGLGPSSLGSSGSSLPGGSGLGGGLGGANGPNGHGSSVPGGVQPGALAGAGGRAAASAARAGASGMPGMGGAGRGKGDKEEERTKSVADYLINQENGDELTGIPQLPKTVPPVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDE3</accession>
    <name>A0A231HDE3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">linC_2</name>
        <name evidence="1" type="ORF">B7C42_01725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775400.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46747">
        <property type="protein sequence ID" value="OXR46747"/>
        <property type="gene ID" value="B7C42_01725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="25258" checksum="8CAA7355D53842F1" modified="2017-10-25" version="1">MAVYDVSNRAAIVSGGGSGIGRAVAHELARSGAAVLVFDLDEDNANTVVEEIRGAGGQAAGFAGDASDPETVRRSVAAAGELGPLRIAVNNAGISGDSALIGDYSLDGWRKVLSVNLDGVFYALREQLPAVAAAGGGAIVNMASILGSVGFANSSAYVTAKHGLLGLTQNAALEYAAQGVRVTAVGPGFIQTPLLGANLDDETQAFLAQKHALGRLGTPEEVAGLVAFLASDAATFITGSYHLVDGGYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDL7</accession>
    <name>A0A231HDL7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46994">
        <property type="protein sequence ID" value="OXR46994"/>
        <property type="gene ID" value="B7C42_00110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="133"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="37504" checksum="B7ADDBEA539087DC" modified="2017-10-25" version="1">MDREVRRRLAVLRHVEEVTGNVAMTCRYFGISRPTYYTWLHRYETEGVDGLRERSRRPRTSPTATRAEVIEKIIHLRQHYHFGPDKIRMYLERYHDIQISKSGVWRILKRLDMGRLPASQRYKRHDRRWKRYEKQRPGHHVQIDVKFVEPLPGKPGTPAVKPVGRRGKFYQFTAIDDCTRLRILKIYPRNNQKTAIQFLDYVLSQLPFAVETIQTDNGAEFQSGFHWHVLDKGINHVYIKPRTPRLNGKVERSHRIDAEEFYRLLDGVVIDDVNIFNAKLKEWQDYYNYHRPHGGLDGQTPYERLQQKTQTGIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE68</accession>
    <name>A0A231HE68_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46997">
        <property type="protein sequence ID" value="OXR46997"/>
        <property type="gene ID" value="B7C42_00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="30919" checksum="5D16CD45CDDFDC40" modified="2017-10-25" version="1">MAGRGEPVLAGVMENVVQCRRWDQWDRWIGEVRALGYETRVIALNSAHALPPTCLPVPQSRDRLYVAYWLKALGRQPDWDKWLRPKAWCGSCEQVVDAVQSWKKPGVEMGRYGVRHGQYAYRCPSKACRFAIVEPITTPASVAIDWTLPPGARIGDREEPLADNTLERIRIGLEKFAGAAMLTPAGGTWRPDGGHPAIRELPTQTCRRELSVVIPPFIAKLRGGGSKKSARALTEPLATSPPPASTTVSCSRRSIRTCICWCPTTAPDARTRPVGRWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE70</accession>
    <name>A0A231HE70_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47112">
        <property type="protein sequence ID" value="OXR47112"/>
        <property type="gene ID" value="B7C42_00234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="25974" checksum="049C6AC5086AEE7E" modified="2017-10-25" version="1">MLSTQLLGSHQQAIATRRLYTWRYGWDTSEVADTIILQDAVSSFLDGKDALSENDLADLWWSIFDTGNPRANEGLERFTEILSVDTEIDGFEFKLGAWKLDIRSNTANLVLSSALIGGILELEGAIHLPGYTLPLVLSMLFKIEAVRLEAKDKVLVLLLQEKTGDDGRPRSVDELYNLLPKKERRVIAKSDFVAFIERLRQAGKAKQEIGGTFRITPDGKEPWIKINVPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEH9</accession>
    <name>A0A231HEH9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC2_membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_00426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47304">
        <property type="protein sequence ID" value="OXR47304"/>
        <property type="gene ID" value="B7C42_00426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="24"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="27287" checksum="A110B8FE4911B759" modified="2017-10-25" version="1">MTTSTAPRAVRPSAGFSWGFLLLELRRMRRNRRTVIFALVMPVVFFVIFGAQNSYRNETYGSANVTAYVMVSMAVYGAMLATTSGGAMVAVERAAGWVRQLRLTPLSPAAYVATKVAGAMVLGLCSVVVVFVAGAVTGAHLTTAAWVGCFLIAWLTSVVFAAFGLFMGYVLPSENVMQILGPVLALLSFAGGLFMPLHGWFETVSKFFPTNGVATLARLPLGDTTAGSAALAVVNIVVWASVFVLGAAVLFRRDTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEY5</accession>
    <name>A0A231HEY5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE12</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_00625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47500">
        <property type="protein sequence ID" value="OXR47500"/>
        <property type="gene ID" value="B7C42_00625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="374" mass="39380" checksum="AFA2C62AAB81D8D3" modified="2017-10-25" version="1">MDFEFTAEQQLLRDTVTEFLAARYDLEKSRAAARVGAGHQPEIWRGFAEEVGILGASLPESVGGFDGGAIETMIIAEALGGALVVEPYVDTAVLGGGLLRRAGGARAEELLRGIVDGSVITAFAALEADSGYDPARVATTARRDGDDWVLDGAKAVVTTAPLATHLLVTARTSDAAGLSLFVVPADAAGLTQHPYRTIDERRAADLVLDGVRVGADALLGAEGAAGESVARAIDEAIAAICAEAVGGMRRVLADTVEYSKQRRQFGVPIASFQVLQHRMVDMHLELEQAVAATYLVTLKLDAEPEVRARAAAAAKATVARAAGFIGQHAVQLHGAMGMTEELAIGHFFKRLTAIRTEWGSADQHIARYAALTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFJ7</accession>
    <name>A0A231HFJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diacylglycerol kinase</fullName>
            <ecNumber evidence="4">2.7.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dagK_2</name>
        <name evidence="4" type="ORF">B7C42_00713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47588">
        <property type="protein sequence ID" value="OXR47588"/>
        <property type="gene ID" value="B7C42_00713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="3">
        <location>
            <begin position="143"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="460" mass="47922" checksum="E9D39F11729E3F5A" modified="2017-10-25" version="1">MDQTPDRPETHPAANGAANGRHGLRGRTRWARTAFVFAAVTVVMPVVFAGLLGTLVLLIVGAGGVVVTVAALYWFVSGRGVLRWLSAAVAVAAPIVVLVLFVRAGLLWVVLLTGAAALAAVVSARRALRPVVTHTTAVDYAAPPPRRPFLIMNPRSGGGKVAKFDLRRRAEELGAEVVLLEGSADVAALARAAVERGADLLGVAGGDGTQALVADVAAAHDLPFLVLSAGTRNHFALDLGLDRADPATGLDALRDGVEMRVDLGRINGRPFVNNASFGVYAEIVRSPAYRDDKTATVLRLLPDLLAAHSGTRLIAHIGATTVIGPQAVLVSNNPYGTSDLAGLSRRDRLDRGVLGAVTVSVSDIRAAVGLIRRTHSRGLTQQTAAAVVVEAGGASIPVGVDGESLLLDTPVRCVVEPGALRVRVPRNRPGTRPAAPALDWKRLRDLAIGRAHAEFATGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFN7</accession>
    <name>A0A231HFN7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maleate isomerase</fullName>
            <ecNumber evidence="1">5.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">maiA_1</name>
        <name evidence="1" type="ORF">B7C42_00774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779557.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47649">
        <property type="protein sequence ID" value="OXR47649"/>
        <property type="gene ID" value="B7C42_00774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050076">
        <property type="term" value="F:maleate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="27102" checksum="DE9BA9AE4AF3A908" modified="2017-10-25" version="1">MELNFPELDGPVAQRGIGIIAPFDLALERELWRWAPLEVSLHLARTPYEPVPVSLEMAELVSDAAHLTAATRNVLHVEPEVIAYLCTSGSFIKGLAYERSLRDTICRAGARDAITTSGALIEAVRKLQLSRLSVITPYDDILTGKLHEFLHEAGCEVLRSDHLGLGGGIWKVGYRTIAERIMAADDPAAQAIFVSCTNLPTYDLVEPLERLLGKPVLTANQLTMWACLGRMKLPMMGPGKWLQNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSS4</accession>
    <name>A0A231GSS4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000088">
        <property type="protein sequence ID" value="OXR39680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39680">
        <property type="protein sequence ID" value="OXR39680"/>
        <property type="gene ID" value="B7C42_08250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="8052" checksum="B0B7DD9C62F8B712" modified="2017-10-25" version="1">MESDEVWLSTDEVAERLKVPKKTLASWAAAERGPRFARMGRYRRYRLSDLLRWEQSRVDEGGGQRRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GST6</accession>
    <name>A0A231GST6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000104">
        <property type="protein sequence ID" value="OXR39648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39648">
        <property type="protein sequence ID" value="OXR39648"/>
        <property type="gene ID" value="B7C42_08286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="6858" checksum="2DFE9BEF21A91DF0" modified="2017-10-25" version="1">MVDLAGAQWFKSSRSGGSKNCVEVAFLADSLVGVRDSKCIAGPALIFTGAEWSAFTASAARGDLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT13</accession>
    <name>A0A231GT13_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RCS-specific HTH-type transcriptional activator RclR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rclR_5</name>
        <name evidence="6" type="synonym">rclR_2</name>
        <name evidence="6" type="ORF">B7C42_03574</name>
        <name evidence="5" type="ORF">B7C42_08172</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000071">
        <property type="protein sequence ID" value="OXR39760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39760">
        <property type="protein sequence ID" value="OXR39760"/>
        <property type="gene ID" value="B7C42_08172"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44018">
        <property type="protein sequence ID" value="OXR44018"/>
        <property type="gene ID" value="B7C42_03574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="209"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="34127" checksum="3FA632022EB95ED0" modified="2017-10-25" version="1">MGLDVLSDAVATMRTGRPHSSRQHKSAPWGMRFPASDGTGFHVVLQGSAWLIIENREPTPLGPGDIVFLPHGRGHALASDPSAPLRAVNPLPDGSWPPPAPDPHTPGAPVTLLLCGAYQLDRRRAHPLLTDLPDVVHLRPRVGAHRSLRAAVELLGTELEESQPGSDAIVTSLLDTLLLYILRAWWLDTEDDGTPRNGWAAALADRPVATALRAIHTSPEKPWTVEELGALGGLSRAAFSRRFTATIGRSPLAYLTWWRMTLAGRLLRSDDTPLHTVAQRVGYTSEFAFAKAFKREYSTPPGRYRAAALDLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTA2</accession>
    <name>A0A231GTA2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ultraviolet N-glycosylase/AP lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdg</name>
        <name evidence="3" type="ORF">B7C42_08078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000057">
        <property type="protein sequence ID" value="OXR39854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39854">
        <property type="protein sequence ID" value="OXR39854"/>
        <property type="gene ID" value="B7C42_08078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="26220" checksum="0CC5927080989C11" modified="2017-10-25" version="1">METPVGDVIDVIRPAGFGKQRAAQLQGLLQRVAADCKERGIRRITLDWLRHLPDDDVESYLTSLPGISEKSARCVVYYSLDRQTLAVDTHVRRILDRLGVVADRKGKVRYADYEAVVPERLRQRLHVNLIHHGRAFCRSQLPKCGGCPLISFCPSGHSAGSRPVVRKPGANLGPHVVSSPARAALSSRHPRRGFTLDVRKRLPQGAGGQVVAGSNPVSPTEKIPSDQRQRGLFVPAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTI8</accession>
    <name>A0A231GTI8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39902">
        <property type="protein sequence ID" value="OXR39902"/>
        <property type="gene ID" value="B7C42_08007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="120" mass="13190" checksum="15C27DAF7FA1EAAB" modified="2017-10-25" version="1">MDVEAPPRAMGYVCVDLVKTMTDINRRAVRVACRLGYDYIGLTRSSSLVIPEALLDHISDHNIELLIVPDLGHLRGRIPPELAELTDIHDLAADRTYERGGGYAPEGGTINPLHPDPAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTV8</accession>
    <name>A0A231GTV8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40049">
        <property type="protein sequence ID" value="OXR40049"/>
        <property type="gene ID" value="B7C42_07894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28657" checksum="3BD736FF1F037610" modified="2017-10-25" version="1">MNTDTTTRSPKRHRRLGLAVALAMSLCGCGNDGLRPPSAALSTTVPTVIAQSSIAGPPAQPPTTDLFGNRLDVVSDEGRPLVQDPDTRPNPSANDYLTAAPAQMSWQRGWGGAALPASGSDGPAVIYHGIASEFADTPQGAALAACDAIARALSAPEGVWQNVVRARFVGDTDAFIARVTRGRTRTPDAARYVTVPDGIRIRPGYRPDFAVVDIATRTRDGYAYASWPMTYDHDDWRVRLPDDIETLWQPGDPIETLAGFGQWRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU18</accession>
    <name>A0A231GU18_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lutA_3</name>
        <name evidence="2" type="ORF">B7C42_07817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778477.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40109">
        <property type="protein sequence ID" value="OXR40109"/>
        <property type="gene ID" value="B7C42_07817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="26167" checksum="5781DB89A9C9C3C9" modified="2017-10-25" version="1">MKIALFVTCLVDAVFPQVGRATVTLLERLGHQVVVPERQTCCGQMHINTGYPDAATALVRNHTAAFERFDAIVAPSASCVGSVRHQHAMVARRAGDDRLATRATEIGSRTWELSQFVTDVLGLDDVGAHYPHRVTYHPTCHSLRMLRVDDRPLRLLRNVSGIDLVELPAAEECCGFGGTFAMKNPDVSTAMLTDKMRHVLGTGAHTCTAADSSCLMHIGGGLSRLRTGTRTVHLAEILAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUG8</accession>
    <name>A0A231GUG8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40273">
        <property type="protein sequence ID" value="OXR40273"/>
        <property type="gene ID" value="B7C42_07698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="25798" checksum="F3A8D785AD46803E" modified="2017-10-25" version="1">MPAAAEDDRYAYSRAALARLALSDARRDLADRSASGVPTDTDPWSAGEHVRAARELVQLAEEVLTRAVVYERSRGTSWEAIGSELDITRQSAHTRFRDDETRWQQALLEPMKSIAGGKLRSLELPEAAYRPTEAGKSLDDWARTHCPECADVPAPVTGNLAPLTTIEEMNQVLAAMQHLYTDSSTPPDPAERLRLTERKAALLERIAVEEGSAQAHETAAGARALATELRAELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUK1</accession>
    <name>A0A231GUK1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron-encoded protein LtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ltrA_3</name>
        <name evidence="2" type="ORF">B7C42_07641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40303">
        <property type="protein sequence ID" value="OXR40303"/>
        <property type="gene ID" value="B7C42_07641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024937">
        <property type="entry name" value="Domain_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01348">
        <property type="entry name" value="Intron_maturas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="593" mass="67708" checksum="DA43CAC3723A1907" modified="2017-10-25" version="1">MQSAETILGVLRERGRQGLPLERLYRQLFNPQLYLLAYGRIYANRGAMTPGVTGETVDGMSLGKIDRIIEAMRHERYRFRPVRRVHIPKKNGKTRPLGMPTWSDKLVGEVVRLLLDAYYEPTFSGRSHGFRPRRGCHTALREVARTWTGTTWFIEGDVADCFGSFDHEIMLSTLADKIHDGRFLRLMRNMLEAGYLEDWVWNATLSGVPQGGVVSPVLSNIYLHRLDTFVETVLIPEYTRGRIRKPDTAYFRVRAARDRAHRRGDHAQARALRRQVRSMPSGDPRDPGYRRLRYVRYCDDTLLGFTGPKAEAEEIKQRLATFLREELKLELSQDKTLITHARTEAAKFLGYEIAVLHNDGKLTRGKRSVNGVASLRVPSSVIKAKQAPYMARGKPERRPNLLNEDDHTIVNVYGAEWRGIVQYYLLAGNVARLYRLLWVMETSLLKTLANKHRSTVSKMARAYAATITTPYGPRKCFEARVERSGRKPLVARFGGIPLRRQLDAAITDRVLVPGIVRRTELIDRLQAGRCEICRSAEDISVHHIGKLADLDRPGRTKPEWAELMVKRRRKTLVVCRSCHDDIHAGKPTPQLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVR7</accession>
    <name>A0A231GVR7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40665">
        <property type="protein sequence ID" value="OXR40665"/>
        <property type="gene ID" value="B7C42_07223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="15750" checksum="18BCEB03B893EE05" modified="2017-10-25" version="1">MRHPTTTLDGMRLNQVTVGSTDLERSERFYRLLGLRLIVENDHYLRFECPAGESTFSVERVETVPADEEITLYFETDDLDGEYRRLSDAGIAFDQSPANMPWLWREARLRDPDGHRLCLFHAAGNRRNPPWRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW45</accession>
    <name>A0A231GW45_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40792">
        <property type="protein sequence ID" value="OXR40792"/>
        <property type="gene ID" value="B7C42_07075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="36158" checksum="293B1348C6A19BAA" modified="2017-10-25" version="1">MAETIATLPETVEAEVALALAAGLTKLSEYQWRTYTHPASAAGDPEVPNSVAWHRAQERNRFREVEAAVREPNLPDADGMMAVSYSVIEEAAHRIGRVAHLIGDARLVDALVAEVRTEQAAIEAAELGDLSGRARQAVELSRADISPVQVHAADALLYADPLASIGRFTDIDPAAAAVAAARWLYLSAQVAAEAAEVHPVHVVAEADNLEALRVETPTLVLERLCAGESPTAVVVDLIADALAAAEGRVRNPARIIEAAEAIERRLRGDELDEDGLTALTDEFRISCLDPARPAVDLLEDLLDAIRGCRLLYCEEYESGFEEAVRAEADDQRPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWS0</accession>
    <name>A0A231GWS0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkane 1-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.15.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alkB_5</name>
        <name evidence="10" type="ORF">B7C42_06798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.3" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41028">
        <property type="protein sequence ID" value="OXR41028"/>
        <property type="gene ID" value="B7C42_06798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018685">
        <property type="term" value="F:alkane 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052869">
        <property type="term" value="F:arachidonic acid omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03512">
        <property type="entry name" value="Alkane-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033885">
        <property type="entry name" value="AlkB/XylM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38674">
        <property type="entry name" value="PTHR38674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="122"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="43874" checksum="1E3656823FA19399" modified="2017-10-25" version="1">MGQSVQTVGKRSGSADPKKHLWMLGLIAPGCALLPSQLVARTGIEAFWWIGPIIVLIVIPLLDWFVGEDGTNPRDEDYERLSHDRYYRWCTYLFLPIQLAGLVIAAYMWSGHELDVVDKLGLAATLGFVSGIGINAAHELGHRVERLERWLAKLALAQSGYGHFFVEHNKGHHARVATPDDPASARLGESLWMFLPRSIFGGLRSAIRLERDRLHRKGLGWWNVRNHILQAWSMTVVLYGALLAVFGPRMLPYLLLQAVIGFGLLETVNYVEHYGLLRRRLPGGRWARCSPADSWNSDRLVTNIFLFHLQRHSDHHANPGRRYQTLRSTQEAPQLPAGYATMILLATVPPLWRRVMDPKVAAHYAGDLGRANIAPRKRERTLAVYRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX02</accession>
    <name>A0A231GX02_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41150">
        <property type="protein sequence ID" value="OXR41150"/>
        <property type="gene ID" value="B7C42_06746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="1">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="425" mass="45690" checksum="A133236473D021AD" modified="2017-10-25" version="1">MRIAIPLTGTRGDVQPVLALGLELRRRGHDVVLGAPPNLVDFATSAGLAARACGPDVQQLYSSEEGQRALAAGNTLRLMQLVARQMAEYADRMNREVVEVCAGADLIVASTVTEDRACSVAEAMDVPLVSLHYYPARANGAYPFPGALPASWAPPAPVNRATWAVAENLRRIVFMRYLNDLRGMLGLPKSRASIAAVLARRRVPEVQIYDPALVPGLPAQWDGRRPFTGFLTLDQDTRHAVGELGDDHTDILSWVHAGEAPVFFGFGSMPISDPAAVLAMVREVSRRLGLRALVSAGWSGMETARTQGDSTVKVVGPFAYDLVFPYCAAAVHHGGIGTLFESLRAGLPTLVCSVSFEQPMWGGQVDRLGLGAHLRFTDLTTERLVRGVTTLLEPERRARAEVFAVTLRTEGAAAHAADIVEAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXM8</accession>
    <name>A0A231GXM8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt/magnesium transport protein CorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">corA</name>
        <name evidence="7" type="ORF">B7C42_06499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41356">
        <property type="protein sequence ID" value="OXR41356"/>
        <property type="gene ID" value="B7C42_06499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="37345" checksum="C87A5475393049C5" modified="2017-10-25" version="1">MPTARAIVDCGVYIDGHRQSGHVTPADALAQVRERGDGFVWVGMHAPDADQMAEVAEIFGLHELAVEDAVHAHQRPKLERYDDTLFLVLRTVKYLEHDPNSVSEIVQTGEIMIFVGANFVVTVRHGEHTALKVVREEMEKHPERLALGPGAVLHAVADHVVDSYLLVTQSVEDDVEGMEEEVFTPRSRLTIEAIYQLKREVVELRRAVNPLALPLQVLSRSSELPMPKEIRRYLRDVADHHTAVAERISDFDEALSALINAALAKVSVQQNTDMRKISAWAAMAAVPTMIAGIYGMNFTHMPELSWTYGYGMVWVVILVICGALFVALRRNKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY16</accession>
    <name>A0A231GY16_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41486">
        <property type="protein sequence ID" value="OXR41486"/>
        <property type="gene ID" value="B7C42_06378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="26223" checksum="2E1A1F6D4C0F7523" modified="2017-10-25" version="1">MMLVHRTDPVRDHATPETSSADRRPQVGSFRFWFATRRWEWSEEVYRMHGYAPGGVVPTTELLLAHKHPDDREEVAKTIARAIELGESFSSRHRFVDTAGNVHNVMVVADRIYDDAGQVAATAGFYIDLTDTLAENERETLSATLPDMIENRAVIEQAKGVLMRMYRINADQAFKVLAWRSQETNTKLRDLAAQIIEELPFVAPPAPETITAFDHLLLTVHTRIPEAKNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY32</accession>
    <name>A0A231GY32_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional activator RhaS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rhaS_3</name>
        <name evidence="2" type="ORF">B7C42_06377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41485">
        <property type="protein sequence ID" value="OXR41485"/>
        <property type="gene ID" value="B7C42_06377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="213"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="33987" checksum="CA3DD37011D05F0B" modified="2017-10-25" version="1">MTVEFDSESLAATEEFLNRNYTTMEIGNATDGPVRSRIARDTLGGVSLDRLDLGFDMSYDADPLNKICLCGVESGWVEENYIDAGTDTFGPGEIGVLTPPELPYSGVIHQARYTITMFDPALLSRVASANRPDTGEVALSGHRTVTPETGDRLTTVISHMQQLAASYDGDVPPLVAATASQYLAATVLHAFPNTAGFEPTPVDRRDAHPLTVRRAVAYMESHIHEDIAVTDIAAAAYVTVRALQLAFRRHLDTTPTAYLKRLRLRGAHEDLITGSADDGDSVATIAAAWGFGHPGRFAALYRRHYGRSPAAVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY47</accession>
    <name>A0A231GY47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41544">
        <property type="protein sequence ID" value="OXR41544"/>
        <property type="gene ID" value="B7C42_06437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023988">
        <property type="entry name" value="MftA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03969">
        <property type="entry name" value="mycofactocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="36" mass="3868" checksum="1C6025DA30003C3E" modified="2017-10-25" version="1">MNEPITSQTVVPAEDALVEDDLLVEDVSIDGMCGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY72</accession>
    <name>A0A231GY72_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase papA3</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">papA3</name>
        <name evidence="2" type="ORF">B7C42_06373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41481">
        <property type="protein sequence ID" value="OXR41481"/>
        <property type="gene ID" value="B7C42_06373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="73"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="468" mass="51610" checksum="99A2657E84106DD7" modified="2017-10-25" version="1">MVDFGLIDEWSPPPGRMVTWVASPEAVARARTAPVHPAPPSLQQEQYLRQADRHAAADFRFSGLCLATAQIPTGGLDREAMTRIVNAFLLRHDTFRTWFDIGADGIVRRHLVPEDVVDFVPIDYGWIDDPAAIRRHVEKTTPDPFQWDCFTFGAIEHGDATTVYLAVDHLHTDGLGQYLSASDFAQLYLSELSGEAEPLPPAASYLDYCVTERAYSDLLTLSSPGVQKWLQLLRGNDNRLPSFPLDLGKRSDGYNRSAHRTVTLLDEQQALAFEEICRANDAEFVGGVFAAAALAERDLTDSDYYFGMTPVSTRTSAAEGNSVGWYVTLVPVAFPLGPDTPVTRTLTLAQRAYENGLRLAPTSFHRVLELLPADSEIKAEPGWVTPMISFIDARDFLGHEFFDEVTAGVYANRAASEEALIWVNRLPSGTTLSVIYPDTAVAHGSVERYIAAMRTVFASIIDHGAETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY82</accession>
    <name>A0A231GY82_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_06218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783587.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41577">
        <property type="protein sequence ID" value="OXR41577"/>
        <property type="gene ID" value="B7C42_06218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="9420" checksum="96939295A21F17C8" modified="2017-10-25" version="1">MLGLGIIGWIIIGGLAGWLASKIMKTDAQQGILLNIVVGVIGGFIGGFLLKLFGVDVEGGGLWFSFFTCLGGAVVLLFLVGLVTGRGRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYA4</accession>
    <name>A0A231GYA4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetyltransferase OatA</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">oatA_3</name>
        <name evidence="4" type="ORF">B7C42_06220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41579">
        <property type="protein sequence ID" value="OXR41579"/>
        <property type="gene ID" value="B7C42_06220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="32"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="494"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="725" mass="76542" checksum="CD6C731AF21DB7D8" modified="2017-10-25" version="1">MLHMTDTAVSGLVNRQADRVHHAPRPGEGFRPDIEGLRAVAVVAVVLFHAGIPGISGGFAGVDVFFVISGFLITGILWREVRAGRTIGLARFYGARARRLLPAAGIVVVATAIGAAVLLPPLQARQVLGDGIASALYVGNNRLALRGTDYLAASEPPSPFEHFWSLGVEEQFYLVWPVLIVASAWVLRRRRTGSAGPLPYLIILAVVAALSFTISLIWTGTLPPWAFFSLPARAWELAAGGLVALSVVVWSRLPHAVAAPAGWIGLVLVVVACTHLDGRTPYPGSAALIPVAGTTLMIVSGCAGPRFGVGRLLTRGPVRAIGGVSYTWYLWHWPVLLLAPHMLGHPLGRVGAIGALMMAGGLALLTQWTIENPVRFAAPLRNSAMRSLACGFACTALATSAAFVLLMLVPAPVGQGTAAPSLVLSTPRDSTAPAADPRDEAVRQLMAQAQSAVTASAEIRAVPSNLTPSLDNAPGDKADVFTNGCVRSWREVGQAECASGDPDSPTTVALVGDSHAAMWNPALEPIAEARHWRLETMAKVTCPLLDLPITSPYLDREYTECEQWRGQVVNRLRNEHPRLIVVGMSRRYGGDFGFVSYDRAWVDSLARLVSELRAIGSAVLVLGPIPDPHATVPTCLSEHLDDATACAPARPAGVNDAGVSAEQAAATAGGGEYADLTPMFCTAGRCPVIVGNTLVFRDDNHLTVSYAQILGPAIGALIDRTLAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYT3</accession>
    <name>A0A231GYT3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpmB_2</name>
        <name evidence="4" type="synonym">rpmB</name>
        <name evidence="6" type="ORF">B7C42_06092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41750">
        <property type="protein sequence ID" value="OXR41750"/>
        <property type="gene ID" value="B7C42_06092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="102" mass="11313" checksum="6CB2EE3775F821E9" modified="2017-10-25" version="1">MSAHCQVTGRKPGFGKSVSHSHVRTNRRWDPNIQRKTYFLPSEGRRITLHVSAKGIKTIDRDGIEAVVARIRARGGNDGPGGGSPRNRGGTRGRRSKRREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYV5</accession>
    <name>A0A231GYV5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41789">
        <property type="protein sequence ID" value="OXR41789"/>
        <property type="gene ID" value="B7C42_06131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="8243" checksum="B52D010138091369" modified="2017-10-25" version="1">MADGQAGIEEGDYTVDMFSTCWMEPLDLTPQKAHQIMQMHRGCRTDECPRRRAALRVLVEEGRLIPDSSRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYZ5</accession>
    <name>A0A231GYZ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenylalanine-4-hydroxylase</fullName>
            <ecNumber evidence="8">1.14.16.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phhA_2</name>
        <name evidence="8" type="ORF">B7C42_06176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41834">
        <property type="protein sequence ID" value="OXR41834"/>
        <property type="gene ID" value="B7C42_06176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="PTHR11473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="SSF56534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BH4_AAA_HYDROXYL_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="28246" checksum="D25E7D3E23C1850F" modified="2017-10-25" version="1">MTVGLDVRSERERVARACRPGQPLPEFVYSSDEDILWSRVFATLRTMHEQLACADYRRAARLVQLPAERVPQMSEVSRMLRSLTGFELAPAIGSQPGRLFYGPMADGILHATPDVRPVTEQSFSPDPDVIHELVGHAVILADPEFAELYRCFGRAANRATSDEERAAIARLFWFTLEVGVVAEKGHPRAYGAAILSSVTEMESFVNADLREFRVEDILAADIDDSICQPLLFVADSVSRMMAEVTSFLRTRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZP2</accession>
    <name>A0A231GZP2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetophenone carboxylase gamma subunit</fullName>
            <ecNumber evidence="3">6.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">apc3</name>
        <name evidence="3" type="ORF">B7C42_05664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.8" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777765.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42065">
        <property type="protein sequence ID" value="OXR42065"/>
        <property type="gene ID" value="B7C42_05664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="214"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="699" mass="74259" checksum="7071ECECEAD092F2" modified="2017-10-25" version="1">MAYVIGIDVGGTFTDAIIADDKGNIMGAKTPSTPEDYAVGVLNAIDGLAEQVGRPREEILSETAYLAHGTTASINALVTGDVAEVGFLTTRGHRDSIYIMNVEGRYLGLSGTEAQDILRTYKPEALVPKHRALEITERIDSRGDVIVALNEDDVRSAVTNLLEQGVSAIAVSLLWSFQNPAHELRVREIIREMAPGMFVSLSHEVSPRIREYARSTSTIMNAQLGPPLRHYLEPLTAELDERGLAGPLLIMQSAGGTISAEDAPQSAITTLGSVLTGGVVGAHRLAQQLGHSEVVTTDAGGTTFLVGLVVDGEPVRTPGTVINKQPVNASTVKVDVIGSGGGAIAWIDAGGNLRVGPKSATAVPGPAAYGAGGTRPTVTDADLVLGIINPDYFLGGKRTLRRDLAESALLEHIGKPLGLSAEEAAAAVYEVQNAQTADLTRRVVVQAGHDPRNFVVYAFGGAGPIHASAYTAQLGAKELVVPLGAGAAGFSAYGLAASDIVVTREMSDPAPYPVDPARVQENFERLEKQALEALQRQGIDFVEITMSREFDARYTAQMFEVTAAAPDGRLDEESLAIMAKNFERRYAELYGADSGFSAAGFQFINYRVRGTGRFAFSPSLPAHPVADGPASAAVKQRRPVFLDIQRGFEETDIYDYSLLRAGHEIAGPAVVEVDSTTVTVPADRVARVDELGNIRITFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H082</accession>
    <name>A0A231H082_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42264">
        <property type="protein sequence ID" value="OXR42264"/>
        <property type="gene ID" value="B7C42_05463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="39" mass="4655" checksum="FEA01C765732C40B" modified="2017-10-25" version="1">MVLRGIDRPDLPEYMTWEELERLPADVADQIELWEGRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0M1</accession>
    <name>A0A231H0M1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug resistance protein NorM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM</name>
        <name evidence="2" type="ORF">B7C42_05589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42389">
        <property type="protein sequence ID" value="OXR42389"/>
        <property type="gene ID" value="B7C42_05589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="464" mass="48894" checksum="F532FFCDF712CBEF" modified="2017-10-25" version="1">MTAAAPRGDGRRLTALATPIALTQLAQVAISTTNIALMGSLGVDQVAAGGLALVLFNQIRTMCVGLITASGNQVATVVSRAEKQHRDPGHEIRDVVRSSFLIATAAGVLGGLILVGLGWSLQWLGQDATVLAEARPMMVALAPGLLPCLWFQVLRQYTVGMRRPQALVAVTLGSVAVNAVVALALIHGWAGLPALGLTGVGVASSVVFLVTFAVFWVMVRRDTALGPTLPVRMWPVRRRTVAAELRLGAPIALTYGSEAGMFSVLALAMGTIGPAALAAHNVVYQLVYIVFQVAVGLSHGASILVSRAVARDEFRRAQNLAWLALRQAAVVAALVGVLYVAAPDLVLRPFLTGRDSATIDLAHGLLLIAVVLQFFDAAQNIGNGLLRGVKDTRAGFRLSLVGYWLVGLPTALLLAFPLGLGANGVWWGLTAGLAATALLMLRRYFSLLHHREGSEPRELADSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1J1</accession>
    <name>A0A231H1J1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_05052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42715">
        <property type="protein sequence ID" value="OXR42715"/>
        <property type="gene ID" value="B7C42_05052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="25407" checksum="DC3AECDF32A6529E" modified="2017-10-25" version="1">MADSDNVRDTGSWKHPHEPHGGGFASRLNWLRAGVLGANDGIVSTAGLVVGVASATAATTPILTAGVAGLVAGALSMAVGEYVSVSTQRDSERALLSQEKRELAEDPDYELAELTQIYRHKGLTEATARQVARELTAHDAFAAHAEAELGLDPNELTNPWQAALSSAVSFTCGALLPLLAILLPPPTWRIPVTFAAVLLALAATGSLSARLGGSNRRRAVLRVVIGGALAMAVTYGIGQIPGVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1M4</accession>
    <name>A0A231H1M4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42749">
        <property type="protein sequence ID" value="OXR42749"/>
        <property type="gene ID" value="B7C42_05086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="42" mass="4954" checksum="DF2D2D2611224C79" modified="2017-10-25" version="1">MALIDASHPVVHVEFRIGDPHRQAKMRAVMDRLRVGNRFRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1R1</accession>
    <name>A0A231H1R1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor KstR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kstR_2</name>
        <name evidence="5" type="ORF">B7C42_05121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42783">
        <property type="protein sequence ID" value="OXR42783"/>
        <property type="gene ID" value="B7C42_05121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="23464" checksum="F4D5840624539979" modified="2017-10-25" version="1">MADPQQNQQVGRRARNMRAKQSRIFEVAARLFAERGFAAVTTQQISDRADIAAGTLFRYASSKGQLLLMVYNEDFRSALETGARRARDIADPVGAITALLRPILVAAARNTENTIAYQRELLFGPPEETYREQGLALVAQLEAVLAEILLTAVAGSGEPTAAQREAARVAGRGLFAVLHMALVRPSTGVHPHHDPIADLHAQIAQLVAGFRSAAVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1W2</accession>
    <name>A0A231H1W2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-glyceraldehyde 3-phosphate reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gpr_3</name>
        <name evidence="2" type="ORF">B7C42_05171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42833">
        <property type="protein sequence ID" value="OXR42833"/>
        <property type="gene ID" value="B7C42_05171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="354" mass="38503" checksum="1801A7F541F1FD2D" modified="2017-10-25" version="1">MALTLDTYRLLGRSGLRVSPLALGTMTFGADWGWGAERDEARKLFDDYVSRGGNFIDTASVYTNGSSERLLGEFTRDNRESLVLATKYTMLRRPGDPNSGGNNRKSMFASVEASLRNLNTDYIDLLYLHAWDYTTPVEEVLRGMDDLVRQGKVLYVAISDTPAWQVARMQTIADLRGWSPLVALQVEYSLIERTVEHDLFPMARELGLGVIPWSPLGSGVLTGKYTTADLDASAAGSPEGSRKNVALANGSLTERGLAIAEVVKQVAAELDRTPAQTALAWTLRNPAVTAPIIGARTPAQLADNLGALDVEFDAAQLERLDAASAVEPGFPHNMLAREMTDTVINGDLTITPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H241</accession>
    <name>A0A231H241_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-responsive transcriptional activator PutR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">putR</name>
        <name evidence="4" type="ORF">B7C42_04795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778346.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42909">
        <property type="protein sequence ID" value="OXR42909"/>
        <property type="gene ID" value="B7C42_04795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="171"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="320"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="388" mass="42872" checksum="27A6FB76E2F52B1A" modified="2017-10-25" version="1">MSLDDTVQDAADRLNTPLIVLDLDLRIAAYSIHDNDARRARLARLLAGWNPVTEDVIRTNDLRAAVRPVRIPAGDSGEAVVLALRHDKRLLGYLVYIDDRPEPQTIAGDMDVLEPVLPDIAMLLALHMSDLRHGVEHSKYLLSDLLHGSQRERRHAAATLVREGLIEDVEHYTVLVHRAPAHLPQSITRLAVDATLDFIGRATTVKVVGAVLGDDGVVLFPRRVNRDRLDRVLDRPGLERVRAGVGSVQDELADAVTSYHEAQIACRAADADPNRYGRTVFWEDLGIDRLLLQLPLDRMTASQFPPGVQRLLAAAQASELAATLEGYLDSGGEIQGTARRLNIHRSTLYHRLDRIREVTGCDISDGATRLDLHAGLRVARLAGLWPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Q2</accession>
    <name>A0A231H2Q2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777902.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43122">
        <property type="protein sequence ID" value="OXR43122"/>
        <property type="gene ID" value="B7C42_05008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="9169" checksum="EA7803E58B455CFD" modified="2017-10-25" version="1">MGNSTAQPLSRDETVDILLDALDPYIASTRHALGLAHTMATVIGGEPLYLLNNAITDYQPRERLVRSASRALRAHPSPGSASAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2W0</accession>
    <name>A0A231H2W0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyl-CoA dehydrogenase YdbM</fullName>
            <ecNumber evidence="3">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydbM_1</name>
        <name evidence="3" type="ORF">B7C42_04560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43138">
        <property type="protein sequence ID" value="OXR43138"/>
        <property type="gene ID" value="B7C42_04560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="255"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="45746" checksum="9B391AE367B303FC" modified="2017-10-25" version="1">MLKPDMTDEEFQPHFEKARQVSEFFRKIGPEYDEKNTFAYPSIKVFKDSGLGALPVPKEFGGLGGSLLHASKVISELSKGDSAITLAYNMHYIMVGIAGSLMSEEQNKYWLGRVADGELIFGPFSEQRAGFSGLADMKAVPQPEGGWRLYGKKTWGTLCEAADIITTNATITDAEGNLPEDFQERVNAESFFIGDFKVDENGQGDGIRIEKTWNALGMHATGTQTIHFEGYYVPAEGFICEWRTGAFGVLEWASLMFASIYLGMQYRVLEESRAVLSKKTLGATFGAIVAQDTKVASVGHIIDGIGDMASRVEISRRVLYQTCQELLDGKDDEWPLELRFPYIGLAKTFIADNVLHMTRHAMSMVGGSSFRKGTIFERLYRDAAASMFQPLNGDQSRTYIGEFLLQPEELAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2X3</accession>
    <name>A0A231H2X3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43205">
        <property type="protein sequence ID" value="OXR43205"/>
        <property type="gene ID" value="B7C42_04627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="22338" checksum="C523BFD0C74BFCAD" modified="2017-10-25" version="1">MAEFDRNEVEAAFRNYVMTGLVYEDWRAWANLFTDDAVYTDHYYGRFTGPGEIVRFLEGTMGAAPQVYSPLKWYLIDGGRVVYEIVNRADNPEPGASPIDFPSLQIIEYAGGGQWRSEEDIWVTAEMADFSARYRRALDAYPQTPQQRLSRRDWGPWVSWARPEPGHVAEPSWVTREGFVPFSGIADIDFGVRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3B3</accession>
    <name>A0A231H3B3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_4</name>
        <name evidence="2" type="ORF">B7C42_04762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43339">
        <property type="protein sequence ID" value="OXR43339"/>
        <property type="gene ID" value="B7C42_04762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="351" mass="38494" checksum="7880C238A35DCD99" modified="2017-10-25" version="1">MTMEFERLGRSGVTVSRLCLGAMSFGAMGNADHDDCRAIIDRALDAGVNFIDTADVYSRGESEQIVGKAIAARRDEVVVATKFFNSMSRDPNHRGASRRWIVRACEDSLRRLGTDYIDLYQVHRLDEATDLDETLGALSDLVRAGKVRMVGTSTFPAEAIVQAQWVAADRGHIAPHCEQPPYSIFVRGAERDVFPICQRYGMGAIVWSPLNGGWLTGKYRGDSTSDEGARFNRLGRGAWRMDSEGAQRKLALLGRLDEIAAEAGTDLITLALGFTLAHPAVTSTIIGPRTMEQLKSQLKVLDTALSDEVLDLVDEVVAPGVTLARADLAYEPRALRHKHLRRAARRIGTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3B9</accession>
    <name>A0A231H3B9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_04240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43373">
        <property type="protein sequence ID" value="OXR43373"/>
        <property type="gene ID" value="B7C42_04240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012827751" evidence="6">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="41494" checksum="BD4B45800121E5BF" modified="2017-10-25" version="1">MFIASGRRLLFATICAVSVATVYSAQPILTQIGDDLGVPSGDLGWIVTVGQLGYLAGLVLLVPLGDTMNRRTLIAAHLLITAVGVVIAATAARTWVLLIGLALAGLFAVVVQTTVAYAAAVSAPRQRGRTLGMVTSGVVVGILGARLVAGVLATTWGWRSVYAAWAVLLVALACLVLVLLPPDTRTGRIRYRQVLHTSRTLFGDRLLLSRGLIAFFLFASFGTLWSGLALPLAASPWHLDTARIGLFGLAGLAGALGAGRAGRWADRGFAHPVTGAALVLLALSWLATAQGSWSLWLLVAGVVVLDFAVQVVHVSNQHLLTAAHPDRTSGIIGNYMLFYSVGSALGAAATTAAYSAAGWTGSSILGAAFAVGGVVVWAIAGAPGVIRNREATGTRSPITSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3C7</accession>
    <name>A0A231H3C7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43354">
        <property type="protein sequence ID" value="OXR43354"/>
        <property type="gene ID" value="B7C42_04777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012466497" evidence="2">
        <location>
            <begin position="31"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="40669" checksum="E6D69A680DCB2F22" modified="2017-10-25" version="1">MIAATLTLRSLAAAAVSACAAAVTGLGSGAADAVPIGPGCPALYVIGIQGTGQSNPDPTADTGVIGALLGQVQAAAPDLVQHSTIPYPAGFGGIVPGGGPAPYAESATEALAGLDAAVTDITNACPSTLLAGVAYSQGAQAMAQFAQQVGAGNGPVSPDKIAGIALYANPDRLPNSPVIPGRPGQTVPDPAPGTPGAVVAAVQILNPPAAGSGIATDGSGYGALTGRVADICTDGDLACSAPDHAALLRVGAEIAAQADLRDPIAALMTINGLFSTAMGRAWTTVLAEDFHTDPGNADYLPGKPLAQRLIDAADPRTPAPGTDQVQAAAQRWDQITAAATANPLGIVPKLAGQLAAAWGQLVADNADLINPAVWVHYGDTVARHNGYLTSGQLASGVAWMTALAHDAAGHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3S7</accession>
    <name>A0A231H3S7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43495">
        <property type="protein sequence ID" value="OXR43495"/>
        <property type="gene ID" value="B7C42_04362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31222" checksum="BD63F13D028B5350" modified="2017-10-25" version="1">MAAGRGRQTDRVSNFPVAAVVCAFIGAVLFAVSAVAQQRAAADVPAGDALVAQLVRNPRWWAGIIGDAGGFVFQVVALALGSVLIVQPILVTALVFALPLAAHYSRRPVTPVMWAHAVALSAALACFLVVGDPTEGISDAPWSTWMWPLILVLGVVAAAVVVSVVIRVTGLQALMLGTAAGLLFGVSAALTQHVIQLFGHGLTTALTNWQTYTLVAGGIVGLYLQQRGYQVGALSASLPAFTVAEPLGAAFLGLTVLDERLRTGTAGTIVVIASVLVMCVAAVRLSRAQAEMPPAGQAAEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Y5</accession>
    <name>A0A231H3Y5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma-F factor RsbW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsbW_4</name>
        <name evidence="1" type="ORF">B7C42_04446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43578">
        <property type="protein sequence ID" value="OXR43578"/>
        <property type="gene ID" value="B7C42_04446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="14656" checksum="F789A2A0672A0DA0" modified="2017-10-25" version="1">MSAEEGLRSTPVEIGVAATVSQLPIVRGLAETLVLLSDFTLDEVADIRLAVDEACSTLIELAVPGSTLQCRFTVGDNDLLVRVAGIAATSKLPDQRSFGWHVLRTLTDGIDVAQEPFDSAISGYPTVVEFRRVRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Z4</accession>
    <name>A0A231H3Z4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779151.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43588">
        <property type="protein sequence ID" value="OXR43588"/>
        <property type="gene ID" value="B7C42_04456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="1">
        <location>
            <begin position="60"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="15500" checksum="9B0D02CEDBAD5E9C" modified="2017-10-25" version="1">MPTLPWVTVERPTTDTVQIMASRLEVRSLRHVPGFLATSIVLRRQARRSPGALGIALKADLTRRTFWTLSAWTDQEAIGAYARTDPHASAIVRARAVMRESTFVFWSVPAAELPIDWSEARRRIAEEREKRSSTTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Z6</accession>
    <name>A0A231H3Z6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent glucose-6-phosphate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd1_3</name>
        <name evidence="2" type="ORF">B7C42_04477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778919.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43609">
        <property type="protein sequence ID" value="OXR43609"/>
        <property type="gene ID" value="B7C42_04477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052749">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase (coenzyme F420) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023934">
        <property type="entry name" value="LLM_FMN-dep_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04036">
        <property type="entry name" value="LLM_CE1758_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="379" mass="42123" checksum="EAF9110A20B025EA" modified="2017-10-25" version="1">MQFGIFTVGDVTVDPTTGIAPTEGERIDAMMRLALKAEEVGLDVFATGEHHNPPFVPSSPTTMLGWVAARTEKLQLSTSTTLITTNDPVKIAEDYAMLQHLSGGRVDLMMGRGNTGPVYPWFGKDIRKGVELAIENYHLLRRLWREPVVDWQGQFRTPLQGFTATPAPLDGTPPFVWHGSIRSPEIAEQAAYYGDGFFHNNIFWNKEHTQEMVRLYRQRFEHYGHGSADQAIVGLGGQVFMAETEAAAKKFFRPYFDNAPVYGHGPSLEDFTEMTPLTVGTPEQVIERTLGFADYAGDYQRQLFLIDHAGLPIDVALEQVEILGREVVPVLRKEFESRRPAHVPSDPPTHASLVAAGPEAPHHLVEPARERLLAAAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H416</accession>
    <name>A0A231H416_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43639">
        <property type="protein sequence ID" value="OXR43639"/>
        <property type="gene ID" value="B7C42_04507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="28789" checksum="1ACE325E7719DA23" modified="2017-10-25" version="1">MKTVGLRENEVNTERQQGARPSVAPAAAAGEGHTRAAVVQLLLEEGPITATAIGQRLGLSPAGVRRHLDALIESGEARAMRSAPWQQQGRGRPAKQFQLTAAGRGRLGHAYDDLAGAAMRQLREIGGENAIMEFARRRVGVIVAGIDRLAQHTPAATSEKAEEIAEAFSDAGFAATTRKVGSGVQICQHHCPVSHVAEEFPELCAAELEAFRELLGTHVQRLATIANGDCACTTHVPLSVPPTSNPPTSNAQPATRAVAQPAAAARNDSGRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4A7</accession>
    <name>A0A231H4A7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781189.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43783">
        <property type="protein sequence ID" value="OXR43783"/>
        <property type="gene ID" value="B7C42_04018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="122"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="36719" checksum="5C0AF7DBBEB143C1" modified="2017-10-25" version="1">MNDVAKVIHLHETDFEARQRPASRRWPGESALQPVTSLTERLAESAPPRSLGDLVRGAVADGIRNTADFARRRLTGDYQVDEFGRDEHLLQSVILPSLRPLSDLWFRVDVNGIENIPSSGGALVVSNHAGVVALDALMLQLAVHDRHPAHRSLRLLAADLVFEMPVVGGLARKAGHTLACPADAERLLRSGEVAGVFPEGFKGIGKPYAERYKLQRFGRGGFVSAAVKTGVPIIPCSIVGSEEIYPKLADIKPLARLLGLPYFPVTPTFPHLGPLGAIPLPSKWTIEFGKPIATEDYAAEAADDPMTMFEVTDQVRETIQQTLYKLLTKRRNPFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4B2</accession>
    <name>A0A231H4B2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubiB_2</name>
        <name evidence="3" type="ORF">B7C42_03974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781218.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43739">
        <property type="protein sequence ID" value="OXR43739"/>
        <property type="gene ID" value="B7C42_03974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="128"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="480" mass="53970" checksum="A6B57917CC3FCE7A" modified="2017-10-25" version="1">MAKELPTSRLARGTKLGVAVAGNVLRAQKTRRSMRGRSEAVRERMAEESMIRATEQMVMVLGTMKGVAMKLGQMLSVLDLDLVPPEHRERFQRRLAVLRDSAPKVSFDTMRGVIEKDFGRTLEELFAEFDAEPIAAASIGQVYRARLHDGRAVAVKVQYPGIDTAVRADLKNLAMFRRVLQSAMPWVTPAVLDELRLNLESELDYVAEAHTQREVAALFADHPFIVVPATMPELSSTHVLVSEYFPGRGFEEIRRLPEAERDRVGEIIYRFYVGSLFTFHEFCGDPHPGNLLLGEDGRVAFLDFGLFNRMDPEHVRFEATCIRAAAEERAEDLRQLMIDHGIIDSPEEISPEDCLEYVLAACEWALIDQDLTITPELASGAFVLAVDPRASEYAGMKQQNLPPEHLFSRRADFLTFGVLGQLEATANWHRIAREWLYGDEPVTELGKQHHAWLARRGLPRKPAKRSAPRKAAGGKRTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4I1</accession>
    <name>A0A231H4I1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposon Tn10 TetD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tetD</name>
        <name evidence="4" type="ORF">B7C42_04088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43853">
        <property type="protein sequence ID" value="OXR43853"/>
        <property type="gene ID" value="B7C42_04088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18747" checksum="A1F9B8E0C34EA87F" modified="2017-10-25" version="1">MDNRSGPRPRRDRTPSVPEDLLPHLRRARDLVDREYARPLDVDELAATAGVSKYHFLRCFAATYGRTPALYLAERRIERAQDLLRATNITVTEACMLVGYTSLGSFSRKFTELVGMPPSAYQAKFAADGVPRIPGCYVFMHGLSDRRPPDPAPDPDGAISEKPAGAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4R0</accession>
    <name>A0A231H4R0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051025198.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43820">
        <property type="protein sequence ID" value="OXR43820"/>
        <property type="gene ID" value="B7C42_04055"/>
    </dbReference>
    <dbReference type="GeneID" id="66724281"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8310" checksum="E1D8B5545CD4B60E" modified="2017-10-25" version="1">MTAITAASRTLGSVNGQEALLTPGQVAALFHVDPKTVTRWAHAGRLGSLRTPGGHRRFRESEVMQLLKSLTTEATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4T8</accession>
    <name>A0A231H4T8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UvrABC system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uvrA_3</name>
        <name evidence="3" type="ORF">B7C42_04120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781097.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43881">
        <property type="protein sequence ID" value="OXR43881"/>
        <property type="gene ID" value="B7C42_04120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="12"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="479"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="519"/>
            <end position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="791" mass="84638" checksum="183BED065ED891D3" modified="2017-10-25" version="1">MTKAATPGRHVADTHDLIRVHGARVNNLKDISVEIPKRRLTVFTGVSGSGKSSLVFGTIAAESQRMINETYSAFVQGFMPTLSRPEVDYLDGLTTAISVDQERMGANPRSTVGTATDANAMLRILFSRLAQPQIGSPNAYSFNVPSVTASGAITVERGGKTKAEKATFHRLGGMCPRCEGMGSVTDFDLTALYDDSRSLNEGALTIPGYSMDGWYGRIYRGCGLFDPDKPIRRYNKRELHDLLYKEPTKIKVEGINLTYEGLVPKIQKSMLSKDVDSLQPHIRAFVERAVTFTMCPECEGTRLSVEARSSKIGDKSIADVCRMQISDLAAWVRELDEPSVAPLLKGLQHLLDSFTEIGLGYLSLDRPAGTLSGGEAQRTKMIRHLGSSLTDVTYVFDEPTIGLHPHDIERMNNLLLQLRDKGNTVLVVEHKPEAIAIADHIVDLGPGAGSQGGTVCFEGDLEGLRASDTITGRHLDDRAKLKDAPRKSSGALEIRGASTHNLKDVDVDIPLGVLCVVTGVAGSGKSSLIHGSVADREGVVVVDQGAIRGSRRSNPATYTGLLEPIRKAFAKANGVKPALFSANSEGACPTCNGAGVIYTDLAMMAGVATTCEECDGKRFQAAVLDYHLGGRNISEVLEMSVAEAEEFFGAGEAKIPAAHKILQRLGDVGLGYLKLGQPLTTLSGGERQRIKLATHMGEKGGIYVLDEPTTGLHLADVENLLGLLDRLVDSGKSVIVIEHHQAVMAHADWIIDLGPGAGHDGGRVVFEGTPADLVADSSTLTGEHLAAYVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H533</accession>
    <name>A0A231H533_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase SixA</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sixA</name>
        <name evidence="1" type="ORF">B7C42_04141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781077.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43902">
        <property type="protein sequence ID" value="OXR43902"/>
        <property type="gene ID" value="B7C42_04141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17953" checksum="39992D359106232E" modified="2017-10-25" version="1">MARTLILMRHGKSAYPPGVDDHDRPLAPRGRREAALAGTWLRETQPAIDAVSCSDAVRTRETLAATGIDAPVVYEHSIYEATPHTLIELIQLTDDAIETLLLIGHSPGMPWTAWELAANRASLPAEELSRKFPTSALAVLEFDRPWSRADPGTGELVRFHVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H546</accession>
    <name>A0A231H546_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43984">
        <property type="protein sequence ID" value="OXR43984"/>
        <property type="gene ID" value="B7C42_04223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="1438"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="2027" mass="222043" checksum="5B6BA25A007F95F3" modified="2017-10-25" version="1">MLSLVTSTQVFTECAGDSRAYWVPLDGGPAVQLTTDDSALQSYMDLMGLSAEQAARMPHASSLTRGLGMKYEWREPNPTAHELTGRGVVALVSDGPIKKIGTPDAIADQVRAQLARTSGNLLAAAQGFATAAVDAGTRDNVTVVLIAGPDPSGRGETPPGAVGTSPWTKPAHREVPAPVDPRTLPWTGGLPQGRAHTTRSAESWIGKVSGNRSAAEIVTTANPYDHHEPGARRVPHRRSDPPRPSTADPSSGTTRAENPAPHQAGEAPGRRVDEGLIGSAPRSEETSSDVPAPPPRSLVVGSAARLYAVAADEPPGETPGYGAVLDTTADPVWIEAHDGSNRISPAVTDFHDLPDDVLSEYVRLAEIAVPIVRAALASGTDVSADDFLDDLGSRIHNGRLQRHWRTATPEQRLPFDDPGYPEQLREHHRRLARAARDSVVAADAVDRTVADPFRSCTTGAAVAAEMWRRHAVRMFGFDMPGIPVELVRELARAIHQLLTKYPYVQLLRTGFGPVSGPRLLAVSDHVAGTDTRYPYTRSITVSDAVAADRGLFASVWADMVNSGRAVGSVAEPVLGLIRREFGYSLNIATRLIAQRKAQTTLIDHHENSHQGPTRWSPREAFAWSSSQFREYGPGEKGRLNSAAALAGAFAAMEHDPRDTSVGEQVLHNLLAELAPQRQAEKDRGREQLTAEYRPVTPMEQQAKLAMAAALRADYGIDIIGLDNPGIPAATAGDLIAAIRHMIARFPILLGDSSEIRILSEVRIVPGDVGNFGHTSFEGIEFNELWMTAPARMHAEAIEQLAAKRLRLDLDRVYFCLAIHELAHLLRRLLPVHAPSAHEVVSRAFEERYGSNDIPALRAWMATQFSSYGIRQEDGALQPDEAEAESVVAAEVDSLTPTEGEAIVHRNFSELAAAEAERRGLPSAEPPIGSRPSSDATESGGRTAYTSRNSRRSGNITGTARAARGATPWSSGDTTPTARKSAPIVDRTDEGTPIGSRPGAVPASLSPDHLRVLLWISRGWTDAEITEELGGKGPAWRYIWELTQRFGFPTERYLMAAEGARRNLVPVQAPFTELRKVLTPRQIVVLAYLSRGLSKREIADKLSISRRTVDTSVDRSLHRIESPSLLMAMPRLVGALDAFGETELARLAESPTDTIAEPGPGEASVNRLTAEEEWVLRLARRGLTHSEIAAEMGTVVAQVRRTLADARKKAGVSRKDQDAALLEAEQARLKEKQSRQAPRPAAEKASPRQPSRSAMLPNLPNPWTVTPSDSGRPGGQPRTGPSVDGGVRTGRPRVETSIQAILEARLLIERKFLDIALVSGQPRPWELFGEQEWLGHLDAREFARGYRGPLTVEFIRELHRKLAARTMPEFGGLLQGTRVRGWGTLHEPLTEEQIAVVDENPLLTYCPGPFTSGEHGIVMHPVVNGEEGAATYRLLESPLTDSEKAAIGADALTSYVPPGEFSEHGLILYPRFRDISAELEKLCTWFNEATTDTARSRPDFDPYAIAAKLQQWFISLHPAQRDYNGRVSRLLMNWFLEKVGLWPSAIEEFDLDIVTRLPEWTEIIRAGSLQYGRWAVATESSDPATDLVTVFGLERKQANYRQAGGRSAPFTPGAHHDADEYARLYHEISQTVESPRHRMIAHGRETSGDQSLEQSTGDSIEAKQTVFQPNPDTPAGELLALGPSFDYIRTLMRIAAEHPHGPSWIGTPDYWSWNLSWLAERGPRISMLAAFFTAALEAERTLGMTNTGPGPLVIVQERPRTADEMLPVHKYVTLRRDTPEESSSAGTADLATVIGGIGRKLSLDELLQYWTLHMVAARTILDIDVTRTHEELAAAESTVFRPIPREGVFGWNFPGCRALPREHRPYLRARWAGDVLLPQVACRETFEFYLTNVVEPYLLAEARHILDEFDSATPSPENEVARWFTSVVVAAMAAPPADAPEILRRALREYRASADNPLIDHFVAAVRDLMGDEYDFGRYIQRNPRPEFLQFARDLQEVVRDRYDPRALAGTPLFANVLAAARSQTPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5A6</accession>
    <name>A0A231H5A6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44030">
        <property type="protein sequence ID" value="OXR44030"/>
        <property type="gene ID" value="B7C42_03586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18480" checksum="05F5B6F72ECDEF7E" modified="2017-10-25" version="1">MRKSNAAAGTLVFFVLTPGTVAGLIPWWISRWDFHQPWLAARILGVLVIGVGLIPLIGAFIEFARAAGTPAPLAPTETLVVSGFNRYVRNPMYLGVVMIIAGQSLLFGKIALLLYAALVWAVTALFVVTYEQPTLAARYGEQYENYRAAVPAWVPRLHPSGSRGGSCAGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5M1</accession>
    <name>A0A231H5M1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 12">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">nadB</name>
        <name evidence="16" type="ORF">B7C42_03749</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 12"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44189">
        <property type="protein sequence ID" value="OXR44189"/>
        <property type="gene ID" value="B7C42_03749"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="14">
        <location>
            <begin position="14"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="15">
        <location>
            <begin position="505"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="450"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR44189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="578" mass="58559" checksum="B907CA38A7E5F2B7" modified="2017-10-25" version="1">MMMTPSIGWEAEADLVVIGGGVAGLTAARTASLRGLRVLTLSKGGPTDTSTQYAQGGIAVVAPDGDTVDSHVADTVDAGAGLCDPQAVRSIVAGGRDAVAALTDLGAVFDLGRDGQVSRTREGGHSTRRIIHAGGDATGAEVQRALNAAGLPVLFGTAALDIVTGPDGVRGVIVVSDQGFGVVHTPAVLLATGGLGQLYACSTNPAGATADGIALALRAGALVADLEFVQFHPTVLFSPGGLGRRPLISEAVRGEGAVLVDSNGDSVTAGVDPRGDLAPRDIVSKAIAGRMRELGTDHVYLDARAIDGFAQRFPTITTSCRAAGLDPRTDLIPVAPAAHFQCGGVVTDTHGRTAVPGLYAAGEVARTGLHGANRLASNSLLEGLVVGERAGAAAAERVASAPEVTAVPEMSLPRIDRTALQQLMSAHAAVVRDGDGLRGAMLRVLHLRGSGTTKSGTTDAPEDAAAQSETGTTAPTPVESGAAPAEMPSPQGVSRLHGEQAGVLAAVEDAALTLTARTLLLAATARAESRGCHTRSDYPEPREELRRSVAIRLGDDGRPQVVADPLTTADPLPAVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5V7</accession>
    <name>A0A231H5V7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777521.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44210">
        <property type="protein sequence ID" value="OXR44210"/>
        <property type="gene ID" value="B7C42_03770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011253221" evidence="1">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="17329" checksum="A3BC34B806A0CE7D" modified="2017-10-25" version="1">MSRITLRPIMFALSCGAVGAAMLVPPTATATPADPIQLAACDFGRQFTTYDWAGYDDYDRRVLELSTGAFHDQFAASAPDRRAHVTSAHVRSEANSVECRTDVADPEHSQVVVTVDRSERSDATLGLPRPERSQLRVFLDNIDGRWLAGRVDTLPPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H645</accession>
    <name>A0A231H645_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44374">
        <property type="protein sequence ID" value="OXR44374"/>
        <property type="gene ID" value="B7C42_03163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="35363" checksum="BBA50BD2359A24AD" modified="2017-10-25" version="1">MITIDNTGERFDPDTPPGPTDHINVTALNRRARKEAAAIQGTTPILAAQAEAEDAERVAAAEPETAARVSAGGGVDIATELRGEIGAAVAGVLALDAIDAAARKVRARIDGEITEITEQQAAKAQREHRAALLAEAWDAASAKQRVPELMAPHLHWSAHVRPQGSAEMLAITMREELNAEHAVRRQARVRERLTDLDALITEQAVAILDTAGSAADTLAEAGLSVSATTDDILNAEDLGVAKAWKAWQGSVARWSEIQSARRWVAVALAHGFSPRHPGQLIADADTTGTEAHTWGAQWVGVAMPTYVVGASAALVWWLRNRPAPAGITESEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H655</accession>
    <name>A0A231H655_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crt_6</name>
        <name evidence="1" type="ORF">B7C42_03282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44493">
        <property type="protein sequence ID" value="OXR44493"/>
        <property type="gene ID" value="B7C42_03282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="32982" checksum="EA8D1D12AB012DBD" modified="2017-10-25" version="1">MTTDATPAPIPDEGEVVTYERRGPIALVTMNRPDYRNAQNSVMTYALDAAFTRAVEDAEVKVIILAGSGKHFSAGHDIGTPGRDHHIEYDNKAALWWDHVDRPGGDQRFARELEVYLGMCRRWREIPKPTIAMVQGACIAGAMMLAWVCDMIVAADDAFFSDPVVRMGIPGVEYFAHPWVLGPRRAKEVLFTGDRFSAEQAYEWGMVNRVVPRAELESHTLELAEKIATMPQFGLALTKKAVNQCEDLMGMRAGMDSVFGLHHFAHAHNAEVGTDSLAGMTAKSMKATATTATTAERSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D0</accession>
    <name>A0A231H6D0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">pheS</name>
        <name evidence="16" type="ORF">B7C42_03837</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777614.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44276">
        <property type="protein sequence ID" value="OXR44276"/>
        <property type="gene ID" value="B7C42_03837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="15">
        <location>
            <begin position="131"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR44276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="357" mass="38583" checksum="BF8E441D00ACE0A5" modified="2017-10-25" version="1">MADEKDAAEQSATPAEALSEEALSAAAAAAEKAFAAAADLDALATAKTEHMGGKSPIALAQRAMGGLPKQDKADAGKRVNVARGRVSDAFEARRAQLLAERDAAVLVAEAIDVTLPARRGPIGARHPITVISEQIEDVFVGMGWEVAEGPEVETEHFNFDALNFLPDHPARTMQDTFHVAPEGSRQVLRTHTSPVQVRSMLSRELPIYVVCPGRTFRTDELDATHTPVFSQVEGLAVDKGLTMAHLRGTLDAFARALFGPDTRTRMRPNYFPFTEPSAEVDVWFPDKKGGAGWVEWGGCGMVNPKVLIASGIDPEVYSGFAFGMGLERTLQFRNGIPDMRDIVEGDVRFTLPFGIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H760</accession>
    <name>A0A231H760_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025347064.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44688">
        <property type="protein sequence ID" value="OXR44688"/>
        <property type="gene ID" value="B7C42_03482"/>
    </dbReference>
    <dbReference type="GeneID" id="66718841"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="13519" checksum="02A1777838172294" modified="2017-10-25" version="1">MDIDNQHVGSAEPSLVRPYSLTAGRTRPTVELALEALVASHPVALERQFELTNIETSIVELCRESPSVAELAARLGIPIGVARVLVADLIEAGHVRVSATLKDDSSDDERRELIERVLSGLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H763</accession>
    <name>A0A231H763_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44721">
        <property type="protein sequence ID" value="OXR44721"/>
        <property type="gene ID" value="B7C42_03515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="2">
        <location>
            <begin position="67"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="16920" checksum="FA6259B0C51B04F0" modified="2017-10-25" version="1">MTTKTSATTNSTTKTSAAVSFSTEERAAMKEHARELKTAARRGGKAAKADGTADVLAKIATMQPADRALAERIHAIVTAEAPDLAPKTWYGMPAYARDGKVVCFFQSAEKFKSRYATLGFNDTARLDEGTMWPVTYALATLTAADEQRIADLVRAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H784</accession>
    <name>A0A231H784_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44652">
        <property type="protein sequence ID" value="OXR44652"/>
        <property type="gene ID" value="B7C42_03446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="36" mass="4131" checksum="9311203B15189B28" modified="2017-10-25" version="1">MYRIVNSFGLLLLNHLLPSIVNYSLMGLYGLHSLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7A7</accession>
    <name>A0A231H7A7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl carrier protein</fullName>
            <shortName evidence="2">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acpM_1</name>
        <name evidence="2" type="synonym">acpP</name>
        <name evidence="5" type="ORF">B7C42_02859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyl carrier protein involved in meromycolate extension.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518485.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44903">
        <property type="protein sequence ID" value="OXR44903"/>
        <property type="gene ID" value="B7C42_02859"/>
    </dbReference>
    <dbReference type="GeneID" id="66721996"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2 3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10775" checksum="7365E47B080A3C04" modified="2017-10-25" version="1">MAALTQEQIVEELGKIIEEVTGIEPSEVTIEKSFVDDLDIDSLSMVEIAVQTEDKYGVKIPDEDLASLKTVGDAVSYIQKLEAENSDAAAELKAKFDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7D4</accession>
    <name>A0A231H7D4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner membrane protein YccF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yccF</name>
        <name evidence="3" type="ORF">B7C42_03461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513275.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44667">
        <property type="protein sequence ID" value="OXR44667"/>
        <property type="gene ID" value="B7C42_03461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="14371" checksum="6778B23DE7DC97E1" modified="2017-10-25" version="1">MTLIRFVLNVLWLIFAGFWLAVGYFLAGILCCILIITIPFGIASFRIGAYVLWPFGREVVAKPGAGAPSLIGNIIWVIFAGFWLAIGHLVTSIPLFVSIIGIPFGWANLKLIPVSLMPLGREIVSSEHAFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7E5</accession>
    <name>A0A231H7E5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnA2</name>
        <name evidence="5" type="ORF">B7C42_02733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515350.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44779">
        <property type="protein sequence ID" value="OXR44779"/>
        <property type="gene ID" value="B7C42_02733"/>
    </dbReference>
    <dbReference type="GeneID" id="66721858"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="106"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="445" mass="49889" checksum="485417B97AAEB792" modified="2017-10-25" version="1">MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVAIAPAELEGAFEEGIGFDGSAIEGFARVSEADMVAKPDPSTFQVLPWSTSKGHQHSARMFCDIAMPDGSPSWADPRHVLRRQLNKAGDLGFSCYVHPEIEFFLIRSALKDGRPVPADNGGFFDQAVHDEAPNFRRHAIDALESMGISVEFSHHEGAPGQQEIDLRYADALSMADNVMTFRYLIKEVAIDEGVRASFMPKPFSDHPGSAMHTHMSLFEGEHNAFADPDDPNNLSETARAFIAGILEHANEISAVTNQWVNSYKRLIHGGEAPTAASWGRSNRSALVRVPMYTPNKQSSRRVEIRSPDSACNPYLAFAVLLAAGLRGIEKGYTLPPEAEDDVWSLTTAERRAMGFRELPSTLDEALRAMERSELVAETLGEHVFDFFLRNKRHEWATYRAQVTPWELGEYLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7J0</accession>
    <name>A0A231H7J0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784274.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44993">
        <property type="protein sequence ID" value="OXR44993"/>
        <property type="gene ID" value="B7C42_02950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008497">
        <property type="entry name" value="DUF779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05610">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009151">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="14116" checksum="68196126970F2C79" modified="2017-10-25" version="1">MGTRVDLTEAAQTLLDNLIRQHGPVMFHQSGGCCDGSAPMCFPRGEFRVGASDVLLGRVGADTPFWMSADQYEYWKHTYLTVDVVPGRGSGFSLEAPEGVRFLIRSRLLTDAEVAELDSGPPPLTGADAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7S5</accession>
    <name>A0A231H7S5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44842">
        <property type="protein sequence ID" value="OXR44842"/>
        <property type="gene ID" value="B7C42_02796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7425" checksum="8B2E0ADD5AE97288" modified="2017-10-25" version="1">MQARSVPELIELLATGERVLVEAGPMDRIWGIGLAADDPRAEDPAQWKGLNLLGFALMDARDVVRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Y6</accession>
    <name>A0A231H7Y6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ampC</name>
        <name evidence="2" type="ORF">B7C42_02866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44910">
        <property type="protein sequence ID" value="OXR44910"/>
        <property type="gene ID" value="B7C42_02866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="44075" checksum="EB02AAC39ACAA103" modified="2017-10-25" version="1">MTVTIGCTMGEVAEIHGEVASGFEPVADAFRRNFTRFGEIGAAVAVYDGDRPVVDLWAGFRDRRGQLPWERDTMVPVFSSTKGMTAFAVASAVSRGVLDYQAPVAQYWPEFAAHGKESITVRQLLDHRAGLPVLDRVVRLSDMADRDRLAQILADQKPLWSPGTRQGYHPITAGLYQGELLRRVDPRHRSLGRIFAEDFAGPLELDFFIGLPEEQSLDRIATLASTSGLDVLRYERDVPLRIAIQMFLRRGLTYRALSSPRTGAPERATRREYLGVESPAAGGVGTARSLARVYGAAAGRTGELPIAPGILDRLATADTVDDVPADDLVLLTRSRYHLGFRKSCGSFRFGSDKRAYGTTGYGGSFGFADPATGLGFGYVMNRLGTAVLDDARARAVREALLRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8J8</accession>
    <name>A0A231H8J8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-responsive regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lrp_1</name>
        <name evidence="5" type="ORF">B7C42_02399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498415.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45274">
        <property type="protein sequence ID" value="OXR45274"/>
        <property type="gene ID" value="B7C42_02399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16455" checksum="DCD8DE68129DA7CC" modified="2017-10-25" version="1">MADAPAKPVLDDIDRLLIRELMADGRATLSNLAEKASLSVSAVQSRVRRLEARGVIRGYSAKVDPEALGQLLSAYVAITPLDPSQPDDAPALLQHIPGIEECHSVAGEESYMLLVRVASPRHLEQLLQEIRATANVRTRSTIILQTFYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H900</accession>
    <name>A0A231H900_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45206">
        <property type="protein sequence ID" value="OXR45206"/>
        <property type="gene ID" value="B7C42_02331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011968929" evidence="2">
        <location>
            <begin position="29"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="28791" checksum="7869A08B5CF10DE2" modified="2017-10-25" version="1">MRMSLHRRVVVPAAALVLAALVSAGCSAEDHSDRPAGAPQQLVGLFRLTPGAAQGNTVTGTWFRMVQPGGTPDKGPYMPNGDSPVQGGSTTLLEPGSGGGLRTGGFQSEPNPGFSGGNSLAAAITKPTKFFAVEFGVSTNPTDPQTQRTVAPPTVVNNDGILTADLSSWAASWNDQEFNQGAPKPPERQDAQVAGAQQAQKVWDWVVQKWFDQPRSGAPQGPSATGTYDAATRAFTLQWTSLIVGGPFNGFTGVWHLEGVFEPAAAQPNSVAPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9A9</accession>
    <name>A0A231H9A9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxypyruvate reductase</fullName>
            <ecNumber evidence="5">1.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.81" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45316">
        <property type="protein sequence ID" value="OXR45316"/>
        <property type="gene ID" value="B7C42_02441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="81"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="152"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="391" mass="41526" checksum="C55A60B9A472B55A" modified="2017-10-25" version="1">MIPAEPGTRPAHPRILVIDPAPGELAIPELEGLAALGLAPTANLRRVADPTLRSEISRRWHSIDLDGFRADDIVAAFDRHGGYDALKCRAGIPLTCDVFERLTASTHDQPLRLVARAASGVDSFDLDAAAERGVTVLSTPGANAGAVAELTIGLMLDALRGISRRDTALRAGDWTAAIGGIPTGSLADARVGLIGSGSIAREVAKRLAPFGAEVWVHGSPRFTARDAQHWPARWTGTLRELMTGCDIISVHVPATAATAGLIGARELRWMRPGSILVNTSRAARGSRRRSRCGTARPGLRSRPRRPRCIRHGGNIFHLSAGIESTHHAQPPCGRNDGAGDESQFRAAAYRDLALLSERSGVHRATGLTAAPGPTTAVGAISSRGRHERRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9C4</accession>
    <name>A0A231H9C4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-ketoadipyl-CoA thiolase</fullName>
            <ecNumber evidence="3">2.3.1.174</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcaF_2</name>
        <name evidence="3" type="ORF">B7C42_01915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784006.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45623">
        <property type="protein sequence ID" value="OXR45623"/>
        <property type="gene ID" value="B7C42_01915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="247"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="380" mass="39809" checksum="F1267B0307C8E722" modified="2017-10-25" version="1">MTSVVLIDAGRSAVIPDDPDLPETPPGLTEDVITALLYRTGLDRSEVSELFLADPRCLPTRCASGPAGWSFEPPPLGLTTTVSASSARSVARAVRTIEKNPEMVAVVAATDFGARATGNHVDTAALHRQQQTAQLVAAWWDVAPEEMAGWARSSYSRSAECAAARDFADEIVCPAAGYATDLFRKPDADDSFRGGEGAGHSRPEGAVPAHPARGASAIILAGEAKANELGVGFRARLHVTDVIRSCAEFGIAPLDSGTLNELLAPCAITLGCLDQLEVPERFAVTPVAWIKETGINEYLVNPRGGDLAFGHLSRSGSLRSLVTMVNSLEATGGLAGALLSSDVHHTTALVLTLADSIAPKGWKDTVVSPGTPATVKKEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9H4</accession>
    <name>A0A231H9H4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776521.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45481">
        <property type="protein sequence ID" value="OXR45481"/>
        <property type="gene ID" value="B7C42_02606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="18329" checksum="8E50DD0642D4042E" modified="2017-10-25" version="1">MTNEHMKAELAGIIGEAKQQLRVIAEIQRDRAELTGTASVRKNRVTVSVNADGTVIETRFGAGIEDLSYSEIARAVTEAAQQASKNLAQRQRELMAPLQERRARLPKLTDLIEGMPDMRLPTPPEPSLAPPDSPERTAAYGEDELRFADAETYPVEPEGRVTDSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9K1</accession>
    <name>A0A231H9K1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45510">
        <property type="protein sequence ID" value="OXR45510"/>
        <property type="gene ID" value="B7C42_02635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011307894" evidence="2">
        <location>
            <begin position="30"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="439" mass="45468" checksum="4AC698E23987EABC" modified="2017-10-25" version="1">MRSRIRSCTAVLFGALIAVAGGMVSAPHAWTQPPAPAAADDFYIPPVPLPAGPPGAIVRAQPASLLFSAPGQPGVVPAISTRMMYLSNDTHDAPTAVTGTYLQPTLPWTGPGDRPLVAYAVGTQGQGDQCAPSKLLPQLAQYQPPFDVIAEYDVLALYSLLSRGMAVVVTDYHGLGTPEMHDFLNRKAQSYAVLDSARAAEQLPNNGLGPRPPVIVYGYSQGGMASAGAAELQPSYAPELNMRGAYIGGPVVDPEYFIGFNEGQPSLSGAVGFTLNGIAADYPETGPEIDAELNDAGKALLRDAAGKCAIAVSIDNPQRQTAQFTSSGQPLTAVIDRSPALSQAFADQRIGGGTPSAPVLIASARNDEGAPFAPIRDVAAAWCSRGVPVQMDANSQLPPISGVIGTHDLAFFPSLAASQMWLTDRLAAAPAASNCAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA66</accession>
    <name>A0A231HA66_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS-type transporter YhjX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhjX</name>
        <name evidence="7" type="ORF">B7C42_02021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45729">
        <property type="protein sequence ID" value="OXR45729"/>
        <property type="gene ID" value="B7C42_02021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="60"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="469" mass="49291" checksum="EA5FEF89A512C17A" modified="2017-10-25" version="1">METGEWLNLYALWHSGHSSATRMIRHALPVTDIRLTDPVPSPPPERPTTRFARGPHPAWTVAAVGFVALLGAAAFRSVPSVLMDPLHEEFGWSHGTIGAAVSVNMLLYGVISPFAAALMDRFGIRLVVACALLLVAAGSGLTVFMTQPWQLMATWGLLVGVGVGSMSMPFVATITGRWFVRHRGLVTGVLTAAGATGQLVFLPLVSMLARDHGWRAPALVVAATALAVVPLVLLFIRDFPSDIGRTAYGAGPGSDAGLRTAAAGGAARALTVLAAIVRRPVFWLLAGGFAICGASTNGLVGTHFVSAAHDHGMPPTTAAGLLATVGIFDVAGTIASGWLTDRIGSRYLLTMYYALRGLSLVILPMLFAPDVRPSMWVFVIFYGLDWIATVPPTVALCREHFGADGPIAFGWVFASHQIGAAIAASGAGVIRDLQGSYQLAWFIAGGLCAVAAVMSLSIRQPRPREAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA86</accession>
    <name>A0A231HA86_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadE_1</name>
        <name evidence="5" type="synonym">nadE</name>
        <name evidence="9" type="ORF">B7C42_02053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45761">
        <property type="protein sequence ID" value="OXR45761"/>
        <property type="gene ID" value="B7C42_02053"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041856">
        <property type="entry name" value="NAD+_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="495"/>
            <end position="498"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="681" mass="74353" checksum="D7AFA047806CB47F" modified="2017-10-25" version="1">MARELPFGSLYRHGFVRVGVAVPSVRVADPEYNAEQTLLLARQADADSVVLTLFPELGLSGYSAEDLFHQEALDDAVRAAVDRVVAESVDIDSVLIVGAPLRVRERLFNCALIIDRGRVLGVVPKSYLPNFQEFYEKRQFSAARDAVDDHTTVAGQRVPFGADLLFEAVNLPGLVLAVEICQDAWVPLPPNVFAALAGATVLTNLSASNIVVGKADYRRQLCVSTSARNIAAYLYTAAGQGESTTDMAWDGQALICENGNLLAESERFAADPQLVTADIDLQRLAADRLRLNSFTDNAHDHHERVTRFRRLEFEAPIPAGAPPLRREIPRFPYVPADPGSRNRRCAEVHHIQVAGLATRLAATGSQHLVIGVSGGLDSTLALIVAAQTMDRLGLPRSNVLAYTLPGFATSTRTLENARRLMRAVGATAGEIDIRPSATQMLRDLGHPAADGAPVYDITYENVQAGERTSHLFRLANMHHGMVVGTGDLSELALGWCTFGVGDHMAHYSVNASVPKTLIKYLIAWTADRGELGPEASAVLHSVLETEISPELVPGAVLQSSEATVGPYELQDFHLYHLLRFGFRPSRIAYLAEHAWSDRTRGGWPDLIPQDQRHEYDLATIKHWLAEFLRRFVQTSQFKRSTLPNAPKVGSGGSLSPRGDWRAPSDAPAAAWLDELARNVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ2</accession>
    <name>A0A231HAQ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speA</name>
        <name evidence="5" type="ORF">B7C42_02201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45909">
        <property type="protein sequence ID" value="OXR45909"/>
        <property type="gene ID" value="B7C42_02201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="407"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="487" mass="52314" checksum="0455D850CEDE1E1E" modified="2017-10-25" version="1">MDHSRAPVLDALAEYRRLGRYGFTPPGHRQGAGADPRVREVLGGALAVDVLAAPGLDDRLSRGGYLSEAEHLMADAVGADAAFFSTCGSSLSVKAAMLAVAGGAEGGLILGRDSHKSIVAGLVFSGVLPRWVPPRWDAQRHLSHPPSPEQVEQAWEKYPDAAGALIVSPSPYGTCADICGIAEVCHRRGKPLIIDEAWGAHLPFHPELPTWAMDAGADVCVVSVHKMGAGFEQGSVFHVQGDLVDVDKLKLCAELLTTTSPNVLLYAAIDGWRRQMVEHGEKLLTDALHTAERARTALDRIPGISVMEDELLGAEASHDLDRMQVLMDVSGTGATGFEVADWLREYRRIDMGHTDHRRILATLSMADDTDTVDALVDAMTAWRVQYRGAGPSPADIHVPAPRELQLESVMNPRDAFFGPEETVPFEKAIGRIAAEQVTPYPPGIPVIVPGELVDAAVVDYLRSGAENGMNVPDPADPTLRTLRVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ8</accession>
    <name>A0A231HAQ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsH_1</name>
        <name evidence="4" type="ORF">B7C42_00997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46034">
        <property type="protein sequence ID" value="OXR46034"/>
        <property type="gene ID" value="B7C42_00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="250"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="502"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="732" mass="75865" checksum="37754BB24EECE8AB" modified="2017-10-25" version="1">MSLTARLNRSAADARRGVVRLHSEALAALGLREWDGISVIGSRRTAAVVGRAPDETPAGVALLDDVTLSNAGVREDSAVVVAPVTVYGARHISVTGSAAAMGAIAESTLRQALLGKVVTVGDAVSLLPRDLGPGTSSAAATQALSRTFAIAWTSELLTVTTTDPSGGPVSVQPNSAVVWGAAAPAADASHDPRGALAPNRPGSRMLVRERPSAVPVADLAGVRAPAAKLSEWLSLALDEPELLRTLGAPPHLGVLITGPAGAGKATLARAVSTPRRIVELDGPTVGASESGTRLREVGLAVSEICSGAGGVLLITDIDALLPEQPEPVATLILDQLRAAVATAGVAFLATTSRPAAVDSRLRAPDLCDREVALTLPTAAVRAELLQQLLRKVPTEDLDLDVIASRTPGFVVSDLAALCREAALRAASRASHDHTDPMLTQADLVGALEVIRPLSRSGTEELAIGSLSLDDVGDMTETKQALTEAVLWPLRHPDSFARLGIDPPRGVLLYGPPGCGKTFLVRALAGTGQLSVHAVKGAELMDKWVGSSERAVRELFQRARDSAPSLIFLDEIDALAPRRGQSTDSGVGDRVVAALLTELDGVEPLRDVVVVGATNRPELIDPALLRPGRLERLVFVPPPDAAARTDILRTASRSVPLGDDVDLAALAADLDGYSAADCAALLREAAMAAMRRDVDAAAIGAEDLATARGSVRPSLDADQVESLRQYAGKRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAS2</accession>
    <name>A0A231HAS2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trehalose transport system permease protein SugB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sugB_2</name>
        <name evidence="5" type="ORF">B7C42_02244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781931.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45951">
        <property type="protein sequence ID" value="OXR45951"/>
        <property type="gene ID" value="B7C42_02244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="644" mass="69474" checksum="8AE817B3A827A88A" modified="2017-10-25" version="1">MTAGHIHAHGLDLEPALTRIAGPVIPGRHPRRWSMWPAQLPALVLILLLLVGPAATTVWTAVRAQWAMVGWCALLVVLVAASTLLWRRDDAVRALVAAAVRGRWTLLRHRLWPTVFRREAPDGASLVARIRRRSLWWPVVVVALVVTIRGIGVELGPGGRGAYVRTLVWVLCALAVLALALELAWRGRRGWWPWPPLILPFGVSAFVAGLALRLLAENPDYRMPVPGVAGQRVWLMSLLIAAFVWCWLGALFALFRAAIAAIEADPVRRGYLEDARGAGRTRARLFELVRPVFLILGLVVAVAAARIFDIILIAVPGSLQYSLDSATVHWWRLVSDPDADPGVAAAYSLPLAVLVGSAAWILQTDVRRHRVGWMRRPSADPVRARRTARGVVRLVAVSSLSLGPLLALVVFSWVGADGPALAGAGSVWQHRELLHAMANTGWVAVWATVLVIGAAFPVAHQLAALPADALRSRIAVVVLVVFTVLPAQLYVGPIRRVIERMGLTGTSFSSLIVVHAAIGLPIAILILRGALLAPSDGPAADALHGLAKPWAVLSRVVSTAWPAVGAVAVLELIQVWNDFFIGLMVSGADVSPWSLLLWGDARQFQENAAHLAAGALLSTVPPVLLLLMTWRRFLVPGLTGGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAU9</accession>
    <name>A0A231HAU9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45866">
        <property type="protein sequence ID" value="OXR45866"/>
        <property type="gene ID" value="B7C42_02158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375772" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="90" mass="8689" checksum="1F2BD764DF06AFD9" modified="2017-10-25" version="1">MRIITTGIATAALTVAAMAGAGAAAADDDPGFNPPKEIVTVDINLLGCSIGAGLGAQLVPTLSAGGFGGPVGIDAGLASRLRSAGCLPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAX0</accession>
    <name>A0A231HAX0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase EphD</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ephD_2</name>
        <name evidence="2" type="ORF">B7C42_02265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042406.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45972">
        <property type="protein sequence ID" value="OXR45972"/>
        <property type="gene ID" value="B7C42_02265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="32112" checksum="78726BB9AD4FEDF6" modified="2017-10-25" version="1">MNPARTPSRHRTVTAPGGDLAVYEYGRPEADTIVLIPGITDTHRIWDRVATGLADSFHVVTYDVRGHGRSSAPTRTHRYRLPHLADDLFAVLDAVSPRTPAHLAGHGWGAIQLWYALGDPRANTRIASATALSAPHLDHLALALRDLRCPRSPWWRLPRLSWLVLGRRLLHWPRLRARIVPQAGTWPTDLLAGARIVSANLAHHLRHPRPQHTAVPVQLILDRADTAALPSLRAHIRRDVDRLWLRELPADPWLPLTEPLLVVEAIANFIDDQHTDHRPIHYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB44</accession>
    <name>A0A231HB44_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ackA</name>
        <name evidence="8" type="ORF">B7C42_01054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781382.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46090">
        <property type="protein sequence ID" value="OXR46090"/>
        <property type="gene ID" value="B7C42_01054"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="41759" checksum="A50B17A91D1814C3" modified="2017-10-25" version="1">MQVLVINSGSSSIKYQLLDPVSATVSASGLVSRIGEPVSEDEVTVEHHSDGKEFEHTGPIADHAAGLRVVFDLFTRSGHDLSGEGLSAVGHRVVHGGEIFYEPTLITDAVVESIDKLSTLAPLHNPANVTGIRSARDLLPDIPQVAVFDTAFFHGLPDAAKTYAIDATVAAAHGVRRYGFHGTSHEYVSGRVSELLGGDPAAHNQIVLHLGNGASASAIRGGRAVDTSMGLTPLEGLVMGTRSGDIDPGIPLHLARTAGLDIDGIDELLNRRSGIKGLSGVNDFRQLFDLIDSGDAAARLAYDVYVHRLRHYIGAYLVDLGRVDAITFTAGVGENNAQVRADALAGLERFGIAVDPVRNAAKDRAARHISPPGAEVAVLVVPTDEELAIARAAAALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB57</accession>
    <name>A0A231HB57_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45986">
        <property type="protein sequence ID" value="OXR45986"/>
        <property type="gene ID" value="B7C42_02279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="21551" checksum="FB52B72DA3AEEEB4" modified="2017-10-25" version="1">MATVVCGASMSLDGYIAGPEESGFEHLFAWYEAGDRAYPSTHPEVRFSMTEADHDHVAAYLDAVGVFVVGRRLFDLTDGWGGIHPFDRPIVVVTHRIPQQWIDSHPGAPFTFVTDGIEAAIERAAVIAGDRAVGVNGGTMARQALEAGLLDEIWIDLVPVLLGGGTPMFDHLGAAPHLLEDPVVVAGSRVTHLRYRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBC9</accession>
    <name>A0A231HBC9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-lytic protease</fullName>
            <ecNumber evidence="2">3.4.21.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alpha-LP_2</name>
        <name evidence="2" type="ORF">B7C42_01123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.12" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043397.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46158">
        <property type="protein sequence ID" value="OXR46158"/>
        <property type="gene ID" value="B7C42_01123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011231004" evidence="1">
        <location>
            <begin position="44"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="448" mass="45521" checksum="E453D672208E149A" modified="2017-10-25" version="1">MLLPRIRLSSAAGRAPRPRLRSAAVAASAAVLVLGPLAATSSADPAPAPAPALPAELAAAVQRDLKISPEEYLHRADVAQHVAAFAATAQRQFPQAFAGAWLDDAGKPVVALAPGQGLDDAKKAAQDAGFGVKDVAKSQTVLRSEKNAFQQWLSGQPEGVAQAVRGVVIDTVNNSIAVRVDKAGVPMPGFVDPAHVIVMAAPPVGPPESDPQVKPIAGEQPNAPRAGGDSYASVAGKMQLVCSTGFNGEDRNGNPVNITAGHCDPNIPAAGTANAPGMFELLPGNHIGAQLGSFQKSILGNQDYSIVSIDAGSRDRFANNLVRVPGAAPIAITGVADPVVGAPVCKSGSRTGFSCGVVNAVDQTVQVGDRDLTQSFSANICALPGDSGGPIVTGTLALGISSASSVADYPICEIPNLIGALTGDAPQLFAQPVNQVLSDNPGLRVRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBN0</accession>
    <name>A0A231HBN0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atsA_1</name>
        <name evidence="3" type="ORF">B7C42_01188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46222">
        <property type="protein sequence ID" value="OXR46222"/>
        <property type="gene ID" value="B7C42_01188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="512" mass="57910" checksum="5AE575ECB7BC7137" modified="2017-10-25" version="1">MPDSKPNILVIWGDDIGITNLSCYSDGLMGYRTPNIDRLAEEGMRFTDSYGEQSCTAGRASFITGQSVYRTGMSKVGVPGAGVGLSPEDPTIAELLKPLGYATGQFGKNHLGDLNRFLPTVRGFDEFFGNLYHLNAEEEPELPDYPHKDTYPRLYDLQRPRGVLHSWATDEDDPTEDPRFGRVGKQRIEDTGPLTKKRMETIDEDVAEACVDFLTRQQRAGTPFFVWLNFTHMHLRTHTKPESVGQAGIWQSPYHDTMIDHDRNVGRVLDALDELGLADNTIVVYSTDNGPHANTWPDGATTPFRSEKDTNWEGAFRVPQVIRWPGHIPARSISNDIVQHHDWLPTLLAAAGEPDIVDKLKQGHAVGDKTFKVHIDGYNLLPYLTGAAEHSPRRGMVYFSDDCDVLGIRFENWKIVFMEQRKQGTLGIWAEPFTPLRVPKLFNLRTDPFERADVTSNTYWDWFIDHDYIAFYGTAIATAFLDTFKEFPPRQEPATFTIDQAVAKLHDFLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBS3</accession>
    <name>A0A231HBS3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gdh_2</name>
        <name evidence="8" type="ORF">B7C42_01264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 6">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781593.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46298">
        <property type="protein sequence ID" value="OXR46298"/>
        <property type="gene ID" value="B7C42_01264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="7">
        <location>
            <begin position="206"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="449" mass="48868" checksum="CA0D4C8AF5CBE9E2" modified="2017-10-25" version="1">MAALDEKLQDIYTEVLQRNPGESEFHQAVREVLDSLGPVVAKHPQYVDAAVIRRLCEPERQIIFRVPWVDDSGTVQINRGFRVEFNSALGPYKGGLRFHPSVYLGIVKFLGFEQIFKNSLTGMPIGGGKGGSDFDPKGRSDAEVMRFCQSFMTELYRHIGEYTDVPAGDIGVGGREIGYLFGQYKRITNRYESGVLTGKGLSWGGSQVRPEATGYGTVFFTEQILDRRGDSFEGKRVVISGSGNVAIYAVEKVHQLGGTVVACSDSSGYIVDDKGIDLELLKEIKHDRRGRIHEYPDIARGSAYFVDSGSIWAVPCDIALPCATQNELNGSDARLLIENGCAIVAEGANMPCTPEAFRLLIDAGVTFAPGKAANAGGVATSALEMQQNASRDSWTFEHTEQRLETIMRGIHDRCLETAEEYGTPGDYVAGANIAGFTQVADAMLALGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC93</accession>
    <name>A0A231HC93_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46500">
        <property type="protein sequence ID" value="OXR46500"/>
        <property type="gene ID" value="B7C42_01470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127245" evidence="2">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="11153" checksum="81206C53CF46FD84" modified="2017-10-25" version="1">MFRVKGNPLLSKSSSRRRLIARIAVAGAVAAAPVAALAVPAFADTPSAAPVDWHDHDHDHDGWRHHHDHDHGPWQPGPGGFLPGGPDGFLPGGPGGFLPGPPPTGSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCA6</accession>
    <name>A0A231HCA6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85B</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpB_1</name>
        <name evidence="2" type="ORF">B7C42_01544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46573">
        <property type="protein sequence ID" value="OXR46573"/>
        <property type="gene ID" value="B7C42_01544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="39572" checksum="1B58AF5FC46D0DE9" modified="2017-10-25" version="1">MRGVTVRWVQQRRRRRSQQPSAPHRTGWLKRSAVGVALATLLPFGVSVAEAGHAAAAFNPTGIDFWVDSAMGPIKSRIFRAADGNTGRVVYALDGMRAQGDISGWEKETNIIPALVNANINVVMPVGGPSSFYADWNAPSNFFGIDTGSVGSSGSASTGSAMTGSSNYNETLGKVNTYKWESFLTQDLPNALSARMGFSSHRNGVFGLSMGGSAALTLAAYHPDQFSYAGSFSGYLNISAPGMREAMRVAMLSAGGYNIDAMAPPWGPQWLRMDPFVFAPRLKANNTRLWVAAGSGIPSPQDAVAPLDIIQGSPLEALALANTRAFQVRMMTLGAGNVTYDFPNVGVHNWHNWEDEVYRMLPDMSANIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCH7</accession>
    <name>A0A231HCH7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781715.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46367">
        <property type="protein sequence ID" value="OXR46367"/>
        <property type="gene ID" value="B7C42_01333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="167"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="42690" checksum="AD05963DEFF16E45" modified="2017-10-25" version="1">MDPVRNPYAPGAGQRPPELAGRDKQLDAFDIVLERISRGRPERSVMLTGLRGVGKTVLLNQLRSTARSRGWGTGKLEARPDQELRRPLASALHMAVRQIAVAHRNPEMVDDFLGILKAFALRATADKGMRERWQPGIDVPAVTGRADSGDIEIDLVELLLEAAQLARDIGVGIAVFIDEMQDLGPADISAICGACHELSQETAPLIVVGAGLPHLPAVLSASKSYSERLFGYHRIDRLDRDSADRALIAPAEREAVEFTEEALKALYDKADGYPYFVQAYGKATWDVAARSPIGAEDVELAAPAAEEELAVGFFGSRYERATPAEREYMRAMADLAGDDGPVPTAAVAKELGRKPASLSPARDGLIKKGLIYSAERGTIGFTVPHFGRYLRGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCL8</accession>
    <name>A0A231HCL8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46651">
        <property type="protein sequence ID" value="OXR46651"/>
        <property type="gene ID" value="B7C42_01625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="32046" checksum="CFC78FFD3B45831D" modified="2017-10-25" version="1">MNECRNRRCGRPIDAFLCQECGDQLVTALDRVAWLEDELSVTELRQDRVSSGLRSGRAPRSPLLFDPTAGELRAGLVNSVQTWARHIAETRGTRIRGPAEEWLADNIAAVRLDEAAGELYRDITERVAAGLALINAQSRKIFRGPCPTIIGQTPAGVAIECGTPLYADAVAEIAYSSSTDDDRQTPAAFVTCPKCNTLHDTARLEARLLARSDNVAFAVVDLVRVLRELGEPVLRNTIDQWIARGKLAPSAWRHDGRTVAHKRADTDKPLYRLGAVRKLRAAGSRSRGRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCM3</accession>
    <name>A0A231HCM3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydiP</name>
        <name evidence="8" type="ORF">B7C42_01689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234853">
        <property type="entry name" value="M.Nce30759ORF1689P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46713">
        <property type="protein sequence ID" value="OXR46713"/>
        <property type="gene ID" value="B7C42_01689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="41929" checksum="24310746CB78F810" modified="2017-10-25" version="1">MVGLFAGIGGLELGLSAHGWHTELLCEIDPGARAVLSARFPDVETHADVTRLRALPAGTELVAAGFPCQDLSQAGRTAGITGERSGLVDEVFRLVRRKRGPRWLLIENVPFMLQLGRGQAMRHITTALEELGYTWAYRVVDARAFGLPQRRQRVLMLASRSEDPRPVLFGTDAGPRTIGDPEVDPCGFYWTEGVRGLGWAVNAVPTLKGGSGLGIASPPAVRLPAGEIVTPGITDAERLQGFSHDWTAPALAAAGVRPGHRWKLVGNAVSVRMASWIGSRLAAPADGVAAEYAPLTAHRWPAAAWGHAGKAYRVPVSTWPVHEPYEDLRWFLDDARLLSARATAGFLRRAARGTLRFPPGFLTDMENHLIRMGGLPREGASVPYVSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCP3</accession>
    <name>A0A231HCP3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rmlB</name>
        <name evidence="8" type="ORF">B7C42_01573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775207.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46602">
        <property type="protein sequence ID" value="OXR46602"/>
        <property type="gene ID" value="B7C42_01573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="37167" checksum="F12C4EAAE2A823BB" modified="2017-10-25" version="1">MRLLVTGGAGFIGANFVHQTVADRPDVRVTVLDALTYAGNRASLAPIADRIEFVHGDIADSGLVDRLVSGADAVVHFAAESHNDNSLARPRAFVQTNIVGTFTLLEAVRKYDVRYHHISTDEVYGDLEADDPAFTENTPYQPSSPYSATKASSDLLVRAWVRSFGVRATISNCSNNYGPYQHVEKFIPRQITNLIDGVRPRLYGAGHQIRDWIHVADHNRAVWDILDRGRIGQTYLIGADGELDNRTVVELLLAEFGRDPGDFDHVTDRPGHDQRYAIDATLLRAELGWRPRYGDFRAGLAATVAWYRDNEAWWRPQKDHTERAYAAAGEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI1</accession>
    <name>A0A231HDI1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47013">
        <property type="protein sequence ID" value="OXR47013"/>
        <property type="gene ID" value="B7C42_00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="93"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="22436" checksum="2D50BC48D04AEA70" modified="2017-10-25" version="1">MALEHALLVSLSERAGSGYELARRFDKSIGFFWSATHQQIYRVLKRMEERGWVTGEAIAQDGRPDKKVYTVSDAGHAELARWIAEPTDDIGPLRSELGVKIRAAAHGDLGALRTEVERHRDQHAQRLELYRLIEKKDFPAPDRLTGTALYQYLVLRGGIRVEIGFVEWCDEVLAGLRGVLRSSSADPEVTAPQPDSVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDX4</accession>
    <name>A0A231HDX4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-(Acetamidomethylene)succinate hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.29" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46945">
        <property type="protein sequence ID" value="OXR46945"/>
        <property type="gene ID" value="B7C42_00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047411">
        <property type="term" value="F:2-(acetamidomethylene)succinate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="25"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="30005" checksum="68FE36FE1DB09084" modified="2017-10-25" version="1">MTLRFTGADGVELAAELTGRWDDPLVVLLHGGGQTRSAWGDAATALTTAGYLVLSLDLRGHGDSDWAADGNYSMDAYAEDLRRIVRCLDRPAALVGASLGGLASIVAAGESPAVDCTALVLVDVVPRLDEAGKATIMSFMLADQDGFASVEHAAEAVAGYLPHRPRPASTSGLQKNLRRRDNGRYYWHWDPRMLSEETSPRNISEERLEQAIANVRAPILLLRGDRSEIVHAENVAAFQAVVPTAEYVEVVGAAHMVAGDRNDMFGSALIEFLDRHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE12</accession>
    <name>A0A231HE12_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47062">
        <property type="protein sequence ID" value="OXR47062"/>
        <property type="gene ID" value="B7C42_00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="17740" checksum="3AF1F1E58B4D40FF" modified="2017-10-25" version="1">MTSVGSVNGAVKAGGTVVLPKRFHAKVDVRWSDMDVFQHINHARMVTLLEEARIPWLFEGERPTAGLRTGCVLADLHVRYRGQLRHEDTPLDVAMWIEQLRAVDFTIGYEVRANGVALDSPPAVVASTQIAAFDIDTQRLRRLTDEEREYLSLWRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEQ8</accession>
    <name>A0A231HEQ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781660.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47420">
        <property type="protein sequence ID" value="OXR47420"/>
        <property type="gene ID" value="B7C42_00543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="32450" checksum="D00270CB56668340" modified="2017-10-25" version="1">MGRTGEYGEIDTDATPAQRTLAFAVRDLLHMTGLPLRQIEKELKAHTERRLEDLEQRQREGQLTRAEEIDLVELKEQRYFSKSALQELAKGKRKRPPKERELKELFNFAHGGQGPRRDWDQLNQWRLALAEPSDGSQLIVCPTCGAATVPTEGCAEAKPAENGLTVPTSAPVPLVEGDRRTGERFDVMLRPADEVVWSPVTVLAGYVSAGKLENANGLMRHVGREADPGETADAIIACGDGGISEAVDTIISHAGARDDLLHVMQIVRSLNERDRRVDSDALLDHALARHASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEV6</accession>
    <name>A0A231HEV6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ilvC</name>
        <name evidence="12" type="ORF">B7C42_00527</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779913.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47404">
        <property type="protein sequence ID" value="OXR47404"/>
        <property type="gene ID" value="B7C42_00527"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="36382" checksum="4EDCE4DF159DF8AF" modified="2017-10-25" version="1">MAVEMFYDDDADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVEVRIGLKEGSKSRAKAEEAGLTVGTPAEVSEWADVIMLLAPDTAQAKIFTEDIEPNLKDGDALFFGHGLNIHFGLIKAPADVTIGMVAPKGPGHLVRRQFVDGKGVPALIAIDQDPKGEGQALALSYAKGIGGTRAGVIKTTFKEETETDLFGEQAVLCGGTEELVKTGFEVMVEAGYAPEMAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDADTKERMKAILKDIQDGTFVKRLVANVEGGNKELESLRKQNAEHPIEVTGKKLRDLMSWVDRPITETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEZ0</accession>
    <name>A0A231HEZ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrH</name>
        <name evidence="8" type="ORF">B7C42_00666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513088.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47541">
        <property type="protein sequence ID" value="OXR47541"/>
        <property type="gene ID" value="B7C42_00666"/>
    </dbReference>
    <dbReference type="GeneID" id="66720631"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="141"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="26257" checksum="7DF9CA297E200DAC" modified="2017-10-25" version="1">MTDPDTAPDRKGYRRVLLKLGGEMFGGGEVGLDPDVVQTVAEQIAEVVSTGVQVAVVIGGGNFFRGAELEERGMERARSDYMGMLGTVMNSLALQDFLQKQGVDTRVQTAITMGQVAEPYLPLRAKRHLEKGRVVIFGAGMGMPYFSTDTTAAQRALEIGAEVVLMAKAVDGVFTADPKVEAEAIMFSEITHKEVLERGLKVADATAFSLCMDNQMPMLVFNLLIKGNIARAVAGEKIGTLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF74</accession>
    <name>A0A231HF74_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">recG</name>
        <name evidence="8" type="ORF">B7C42_00593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47468">
        <property type="protein sequence ID" value="OXR47468"/>
        <property type="gene ID" value="B7C42_00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="306"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="504"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="763" mass="82965" checksum="3F1140EE155B8B81" modified="2017-10-25" version="1">MATLSDRLDHVLGVKAAEPLADAFDMHIVEDLLRHYPLRYATQGQPLTEEAPEEGAHITVVGRVSKTELRPMRQRRGKLLKVELDTGSAKPVEITFFNGDKVNYLVKQGVRAMMSGTVHWWRPDRWNLSHPSYLILPETAESVDSLTSVRGGGALRGLAESAKGAGGVDISFFEREYIPVYPATAKVQSWDILACVRQVLDQLDPIDDPLPPDLREDHELLPVSDALRLIHLPERKSDIDQARQRLRFDEALALQLVLAQRRHDAAGRTARPCPPRSDGIAVEFEQRLPFELTAGQNKVIAEISGDLSRPHPMHRLLQGEVGSGKTIVALHAMLQVVDAGLQCALLAPTEVLAAQHYRSLRSMLGDLGAAGELGAADHATKVVLLTGSMSASAKKAALLDVVTGTAGIVIGTHALIQDAVEFFDLGMVIVDEQHRFGVEQRDALRAKAKDGITPHLLVMTATPIPRTIAMTTLGDLETSTLTELPRGRSPITTRVVPARMKPAWVERAWERIREEVAAGRQAYVVCSRIGDEEDDGATKKGAKSKGKTRKKADDDAGEEPTTHAAIDVFETLRTGALADLRLGLLHGRLPTDDKDRVMRSFNDGDIDVLICTTVVEVGVDVPNATVMVIVDADRFGVSQLHQLRGRVGRGKHPGLCLLITETSPMGTAMARLEAVAGTLDGFELSVLDLRQRREGDVLGSAQSGTARSLKLLSLLDDLDVITTAQVLAREVVDADPGLTDHPGLANMMHAAVDSERLEYLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFG8</accession>
    <name>A0A231HFG8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47624">
        <property type="protein sequence ID" value="OXR47624"/>
        <property type="gene ID" value="B7C42_00749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013207">
        <property type="entry name" value="LGFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08310">
        <property type="entry name" value="LGFP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012240618" evidence="1">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="20698" checksum="4D15C58AFBF8F409" modified="2017-10-25" version="1">MASSGRRQSRRSARRAGLRTAAAAAAALAALTGTGAGLAAARPVGAFDVGGAIEKEYDRAGGTAVLGNPIGPESDANGGKFQVFDRGCSIYWSVGTDAHAICGLIRDKWGSMGWENSPLGFPLTDEAKAGKDGKGRFTRFPGGVIVWSANTGAHPVWGSILGMWEGSNADGGYGLPTSDEYDYNGGKAQDFQGGQITWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFV6</accession>
    <name>A0A231HFV6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518399.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47762">
        <property type="protein sequence ID" value="OXR47762"/>
        <property type="gene ID" value="B7C42_00887"/>
    </dbReference>
    <dbReference type="GeneID" id="66724528"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="57" mass="6029" checksum="D35371D46564AFD0" modified="2017-10-25" version="1">MSAIDKAKNKLEDAAGQAKEKLGAATGDPDKKNEGKADQTKSNLKDAGEKVKDAFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFX7</accession>
    <name>A0A231HFX7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47585">
        <property type="protein sequence ID" value="OXR47585"/>
        <property type="gene ID" value="B7C42_00710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024341">
        <property type="entry name" value="DUF2631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10939">
        <property type="entry name" value="DUF2631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="94" mass="10132" checksum="D0A84461574075F5" modified="2017-10-25" version="1">MAATELEPAKSAGVVTKVDPAEVPSAAWGWSGESRRTFRIAGWVVVVILLAMLFENQQGHTSGTGYTGYIFLIGFAVALAAILIRDSIIQRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGC7</accession>
    <name>A0A231HGC7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase FadD13</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47745">
        <property type="protein sequence ID" value="OXR47745"/>
        <property type="gene ID" value="B7C42_00870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="151"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="420"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="512" mass="53974" checksum="6CFF7C589B8FFE81" modified="2017-10-25" version="1">MTTEPAVIEISRHGNPFPRTGVAERDGIAHYTGLPATLLDMLRAQVERRPDSEAVVELARDRLTYRQLWERAARVAGGLRAAGSEPGDRVAVRYPAGVDWVLAFWGTVMAGGIVVAVNTRSAGPEIDFVLTDSGARIDLAPGVPLPDGEPVVTQDLSAADIAAIFYTSGTTGHPKGVPTTHEAFVTNAENMVRCIGLPRDIGEGMRTLISVPLFHVTGCNSQLLTAAHLGGTAVIMPALGVPELIAALSTERISFLVTVPAVYALMVRHPDFGAADTAAVRWVGYGGAPIAPSLVLALKDAFPNAQVFNGYGMTETASLMTVLPDTDAVDHADSVGYAVPSVQLGIVALGDEPGVGELVVRGANVTGRYWHRADADAATIVDGWLHTGDVVRVDDAGRVHIVDRIKDIINRGGENVSSVEVEAVLLAAPGVADAAVLAVPDAVMGEKVGAVVVADRDGIDIPTLIEHCRERLADFKVPQYVTVVGEPLPRNAGGKLLKAALRERTTWGEPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGF2</accession>
    <name>A0A231HGF2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782853.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47797">
        <property type="protein sequence ID" value="OXR47797"/>
        <property type="gene ID" value="B7C42_00922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29676" checksum="76EA11C0A205BCB7" modified="2017-10-25" version="1">MDLNTVEDVIRRPSARPGSDWHAGDAWLAGGTWLFSEPQPTVRRLVDLTALCWPSLVPTDQGLEIGATCTIRELHEFAPPQDWSAGSLLRIGCEAFLASFKIWNAATVGGNICMSLPAGPMITMSVALEATYRLWATDGTERTVAAGNFVGGNHLNALGPGEILRSIHIPAAALRKSYAHRRFTLTKLGRSTIFMVATRTPGTDDLTLSITAATAYPIVLHFDSAPDADTVRDRIDAIPADVWFADPNGTPEHRRHLARHYAEELRAELGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSS9</accession>
    <name>A0A231GSS9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000793">
        <property type="protein sequence ID" value="OXR39531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39531">
        <property type="protein sequence ID" value="OXR39531"/>
        <property type="gene ID" value="B7C42_08401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="45" mass="5128" checksum="49E7A29CCA002131" modified="2017-10-25" version="1">MARLGVWSGHGEQLDLHQPTFDIDERALAVGVRVFTNLVLQQRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTH9</accession>
    <name>A0A231GTH9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxosteroid 1-dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ksdD_3</name>
        <name evidence="5" type="ORF">B7C42_08053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39878">
        <property type="protein sequence ID" value="OXR39878"/>
        <property type="gene ID" value="B7C42_08053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047571">
        <property type="term" value="F:3-oxosteroid 1-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="15"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="521" mass="54935" checksum="229AA4AC9207D6CE" modified="2017-10-25" version="1">MGWVDSVVEWDLDCDVLVVGSGGGALTGAYTAAREGLRVVVVEATEYFGGTTAYSGGGMWFPGNPVLRRAGDDDTIDDALAYFAAVVGDRTPASLQRAFVTAGAPLVEYLEQDEALRFQVLPWPDYFGKAPHARAGGRHIIPQPLPAERLGELRPALRPPLGSDRGIEPLPEELIGGQALIGRLLLALRERTDAELMLRARCRELVRLGGKVAGAVVATAQGTRRIRATRGVLIAAGGFERNAAMRTTFGVPGQARDSMGPPGNRGAAIEAAIAIGADTDLMSQAWWSPGLTHPDGSSTFSLWFTGGILVDRHGRRFTNESAPYDRLGRDVLAAIGDDRITLPYWMIYDSRAGLQPPVLFTGIPLAKRQAYLDAGLWHTADTLEELARLIGVPAADLIATVERFNGFAAAGIDEDFGRGSEPYDTSVPGSPNPLVPIEQAPYCAAAFGLSDLGTKGGLRTDAAGRVLDRAGDVIAGLYAAGNSMAAVSGTVYPGGGNPIGASMVFSHLAALDMAEAGQEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTI7</accession>
    <name>A0A231GTI7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782311.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39888">
        <property type="protein sequence ID" value="OXR39888"/>
        <property type="gene ID" value="B7C42_08034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="215"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="411" mass="43582" checksum="862098D47EEFD86C" modified="2017-10-25" version="1">MVERRPLVLDGGTVKELADGDSLQRALPLRTMILPHTNGGLGGTVATSLAAGTAGSTRFVVKLPVDVNRWRIKIRNRDSSETAKTSATLKKLVVGQHSLPGTGDASDTGSFAGSAATTIVSTDQTIPGDGSYYVSPWVTTAGALFTANQEWLLAFGWTFASSTAVQTGAGKAWTWTNATSGTDPTVAGSGGTVTFVPFEWVIEYECTTRRQVCFVIGDSIFEPIGGGRGTSSASIAPTPLWRGNVYLWAAEHNRLVVNISLAGWKLSDYATDMSNVIIAHIWNRLSLGTYPIDELLISGGSNDAFGGGGTLATMQAAVLTLISRVQTLASFTGPVYMGTIIPRTTTGDTVRAAYNDWLSLKPSFCTAVIDFAGAMRGASSTALWPDYTCDTIHPSWLGHRRMATELATMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTP9</accession>
    <name>A0A231GTP9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782399.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39925">
        <property type="protein sequence ID" value="OXR39925"/>
        <property type="gene ID" value="B7C42_07988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="24029" checksum="CCB775A234369A98" modified="2017-10-25" version="1">MSSIASDLATAIESVWANLRTRHPDVPDVVVTMASGSAGRRGLRLGAFGADRWEHGRQVLPELFVGGEGLAFGARDVLATLLHEAAHGAARTRGISETSRGGAYHNGKFRDLANEFGLHVERDPRIGWSTTTLPEPTAEQYAGEIATLTTAIVAHRRSEHDLAAKDGDGEDGDGKEKAPRSGSALVCSCNPVRRVRAHKKTIDAGPILCGICSQPFTMPAPEDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTR1</accession>
    <name>A0A231GTR1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40017">
        <property type="protein sequence ID" value="OXR40017"/>
        <property type="gene ID" value="B7C42_07901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="16779" checksum="A2672176F318B2FA" modified="2017-10-25" version="1">MTTTGAAGGSRSTHEQRLAVRASSGPHLLAWVAATRQTFTICRPDGHTVAHDRFHRDLIIDSGDAAVEAAALQAIWLAARGKDLWGADVATLRIVTSRLVTDPGSLRLAASSSGLVLELVVDATATNPATSHQLGVWVDWRRVDLTCFIQHPRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTX6</accession>
    <name>A0A231GTX6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782753.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40070">
        <property type="protein sequence ID" value="OXR40070"/>
        <property type="gene ID" value="B7C42_07874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="424" mass="46203" checksum="D08C0F6C795C2019" modified="2017-10-25" version="1">MTALDEPLGFTNPDYYRDAASQTERQLRADFARYYQLREIAPSAATAEARAEFNSRADELAIRWARHESEHWRGTWAGLQRVVAGWRTQPEIARRNYDQIARARATGEIAIDDDIWRTLQQARLITGHGTGTTTGSSQDAARRYPYLQSNMGATPAPGPAGGEQVDRRTAVERTLGAPRNPTVALPSLAQVDAVIADTDALLETEETAADLDDGREARKMLLPRAVREARISADYSHTETWERRHVEALREIQDLAAEHSNVADHLDGTDDQARIARLDRLRAGLSAARRDALAIGLTDEQVQTAYTTGRDGTYWATQPSDPQLGRIAQLLEHRDLARATAESYRNQLSAAIARTADPASPVAHSSSVEGIDALALSQASGPGAAITTAIDTALPDTDLGEWTSTATGSASKEAVSQLDREMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUF8</accession>
    <name>A0A231GUF8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">B7C42_07723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40208">
        <property type="protein sequence ID" value="OXR40208"/>
        <property type="gene ID" value="B7C42_07723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="317"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="438"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="450"/>
            <end position="455"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR40208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="695" mass="74383" checksum="D6FEE6EB9688AF80" modified="2017-10-25" version="1">MTDTDLLATPGVDTANPSDGRESDSGQISKMSEHTDVARSGLTGMLLPQLRALAGELGIRGTSGMRKGDLIAAIKENQASSGKSARGGRGDAKSAEADTGAEAAAKSASNAATESGAAVKTESPQTSENAAESAGKGRTKNDAPKGTRNGAARGQQQTLDGVGTENASAKAETAESAARPADSGDESGRDGGQRGRGRQRRGRDQRGEGGENRGENRGGEARAETKTEPKAEGGEAKTDQESGDRRRDRNQSGGQNQSGQNGAARGGDRGRDQRGEDDEEGGRGRRGRRFRERRRGGRDREGGEGGREVEIREDDVLQPVAGILDVLDNYAFVRTSGYLAGQNDVYVSMNLVRKNGLRRGDAITGAVRAPREGEQGNQRQKFDPLVRLDTVNGSDVESARRRPEFNKLTPLYPNQRLRLETTPNKLTTRVIDLIMPIGKGQRALIVSPPKAGKTTILQDIANAIATNNPECYLMVVLVDERPEEVTDMQRSVRGEVIASTFDRPPSDHTSVAELAIERAKRLVEMGQDVVVLLDSITRLGRAYNNSSPASGRILSGGVDSTALYPPKRFLGAARNIENGGSLTIIATAMVETGSTGDTVIFEEFKGTGNAELKLDRKIAERRVFPAVDINPSSTRHDELLMSPDEMAVIHKLRRVLSGLDSQQAIDLLIDRLKKSKSNVEFLMTVSKTAPGALDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUK9</accession>
    <name>A0A231GUK9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG_37</name>
        <name evidence="2" type="ORF">B7C42_07743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40161">
        <property type="protein sequence ID" value="OXR40161"/>
        <property type="gene ID" value="B7C42_07743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="28729" checksum="612486C67127F805" modified="2017-10-25" version="1">MSRVWFITGSSRGFGRRFAEAALSRGDRVAATARSAGSLAPLAAEYGDALLPIELDVTDRAAVGDAVARAHSAFGRLDIVVNNAGYGLFGAVEELSEQQIRDQFETNVFGALWVTQAVLPFLREQRAGHIIQMSSIAGVIAVPNLGGYNASKWALEGLSDSLAQEVAGHGIHVTLVEPARFATDWSGPSAVHADPLPAYDSVREFARSRGTFSPGDPDAAGAALLRIVDAETPPLRVFFGTTPGKVVPRVYAARLESWQEWAEVAELAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUL3</accession>
    <name>A0A231GUL3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40313">
        <property type="protein sequence ID" value="OXR40313"/>
        <property type="gene ID" value="B7C42_07651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="25059" checksum="D6BD776B7FF3F97F" modified="2017-10-25" version="1">MTYPSSECCASHSKLRHRTTDVNRNLSVNVHRTIDAFRSLYLPWWRRCAAAGRPCRGRWIVMEAVIGESCSVSVPHHDVEARVARHRECGAAMTAAPAPSWPGFPKQAELQGDCATVPTGMTVEAAHRIMQQHAHWSGTPCARRAAALRHLVALGRYVLDKRRCRVRVRFAQSDVSVDYQCTREIAEAFATRMRRRFDSIVVIDDRVHPDLPPLPCARLWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUQ9</accession>
    <name>A0A231GUQ9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb_2</name>
        <name evidence="6" type="ORF">B7C42_07623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40285">
        <property type="protein sequence ID" value="OXR40285"/>
        <property type="gene ID" value="B7C42_07623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="17641" checksum="D84857F75146A85E" modified="2017-10-25" version="1">MAGDTIITVIGNLTAEPELRFTPAGVPVANFTVASTPRVFDRGTNEWKDGGVLFLRCNIWREAAENAAESLTRGSRVIVSGRLKQRSFETREGEKRTVTELDVDELGPSLRYATAKVNRVNRNNRSNGAGSSGNGFGSSGGDDPWAAGDAPNAFAGAAAGFGDEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV02</accession>
    <name>A0A231GV02_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyl-CoA dehydrogenase YdbM</fullName>
            <ecNumber evidence="5">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ydbM_2</name>
        <name evidence="5" type="ORF">B7C42_07551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783538.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40385">
        <property type="protein sequence ID" value="OXR40385"/>
        <property type="gene ID" value="B7C42_07551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="132"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="252"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="392" mass="40991" checksum="239A1F8115604BFD" modified="2017-10-25" version="1">MTTAPSGYPVLTVPDTSPAALAALTTEIAATAAEYDRSGDVPLAGLRAAHRGGYLTATIAARYGGPELDHHRVARILVALGEGDPSVALIAANNLGVHRTQADTGGWPDTVYAELVRRSLDGPALVNAVRAEPELGAPARGGLPATIARRTESGWILDGRKSFATGGRALTYHVVWAATDESPQRVGHFLVPADAAGITWHDTWDHLGLRASNTHDVTYTGVAVPAENFREIPFVDGVYRDPAATSGPASFGHSALYVGVARAARTAFTAYARARVPSALGKPIAETERIQAVAGEIESQIVQAETLLYGTLHRLAAGEPGVPQQLSAVKVLIARSAIAAVETAVAALGNAALTRHNPLERHLRDVLCVRVHPPQEDAALLAAGRAILRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV12</accession>
    <name>A0A231GV12_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40422">
        <property type="protein sequence ID" value="OXR40422"/>
        <property type="gene ID" value="B7C42_07480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="16140" checksum="25880A5436B59108" modified="2017-10-25" version="1">MTILQPQRGGIPRPDPTPVSRPFWDGCVVGELRYQRCRTCGHAEFDPAWICRVCGGDDLDWQLSCGTGEVYSYTVVRRPQTPEFDSPYVVVIVSFDEGFSMLTNVIGCDLGDVHVGMRVRVCFHDIGEGVHLPYVEPVVKGNHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV61</accession>
    <name>A0A231GV61_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40509">
        <property type="protein sequence ID" value="OXR40509"/>
        <property type="gene ID" value="B7C42_07448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="29162" checksum="30F6C8A04044D39A" modified="2017-10-25" version="1">MSIPSQAPITSRRQAYRLLRPHLVPLATLALAADNAAAQMSSALFRGPRRQRLDSKTRGLAVAALWTEGAAEWVDANESPTMRVFEPYGWTELLVGNLHVRIQRDTQRPINARRSRRRQQLPDEQLPLPMQLNELAPVTNIDILADLNSDGRVSGVYVTAPLGKGHAWNAIEVDLTPARRMLVSWQARRVPWLDSITRYEEVAGYDDLADRVKRLEAVLGRTAHLNPIDALHGEDDQQQRRPGFRVPPRKKPQTGNGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVG5</accession>
    <name>A0A231GVG5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40596">
        <property type="protein sequence ID" value="OXR40596"/>
        <property type="gene ID" value="B7C42_07281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="46" mass="5124" checksum="B7AA4D9636B6E533" modified="2017-10-25" version="1">MAEGSDAPLRELEQALRILINRLGARVPEASPARISRAWYIRCMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVH3</accession>
    <name>A0A231GVH3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase SadH</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sadH_6</name>
        <name evidence="2" type="ORF">B7C42_07308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909798.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40623">
        <property type="protein sequence ID" value="OXR40623"/>
        <property type="gene ID" value="B7C42_07308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="30708" checksum="547E498187290694" modified="2017-10-25" version="1">MKDFGDRVVSVTGAGSGIGRAIALRLAGEGARLALADLDAERAEETAAMCGASGAESRHYKLDVADRLAFENYRNRVVEDFGSVSMVINNAGVALGADVLEMDWNDFEWLISINFWGVVNGTKLFLPDLIESGDGHVVNVSSVFGLMAIPSQSAYNASKFAVRGFTEALRQEMRIGRLPVGVTCVHPGGVRTNIVRNARGVGEIGDQQKIVASFDRIALTTPDRAAEQILRGVRRNRPRVLVGPDAVGFDFVTRVVGPRYQDLNAPLARLGYAIGRRSGLMNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVP9</accession>
    <name>A0A231GVP9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytochrome-like protein cph2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cph2</name>
        <name evidence="5" type="ORF">B7C42_07244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40686">
        <property type="protein sequence ID" value="OXR40686"/>
        <property type="gene ID" value="B7C42_07244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="300"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="443"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="722" mass="79345" checksum="EED0F3769B43CDC4" modified="2017-10-25" version="1">MAWDGSEHDGPHADLAHRWAAALGGGVRDHVVPMSVSEAHQLLLTLARGLIDAADSGGTARVAELGGDLARAHFVGDEVLGRTMTVLATYFAELDIASGRAAELIGAFAGGYVRAFRAWLLSEQESVRTADIAARSVVEEQLRASEARLRAVFSQAGIGTGLSDMTGRIIEVNNAFAAMLGYEPEQMYELEVTDLTHPDDPPGMWELYAGVLRGDHDHAQMEKAYRHRDGHTVWTNINVSLIRDDHGRPQYTLVLVEDISEQRELRERLSYRAHHDPLTGLANRSRFFDALTEAFADPDARVGLCYVDLDHFKAVNDTFGHSIGDELLTRAAARLCACAVGENNLVARMGGDEFVILVPRTRRRRELIDLARTVLDAFTVPFDIDGHRLRIGVSIGVISEQAAETTTEELLQAADSTMYWAKTDGRGRYAVFAPSRRRREHTRAELLADLPGALARGEFFLDYQPIVDLGDHRPVAVEALVRWHHPQLGILSPARFIDLAEGGGHIIALGTVVLEQACREGRRWCDRFGDQAPVVSVNVSAEEVADPAWLERVQKIVADTGIPADRLQLELTERTFMHAIGRPLQALHTLAESGIRIAIDDFGTGYSNLAYLGQLPLHVVKLAGPFIHRIRNAGTVGRSDLLILETIIDLSHDLGLSVTAECVETRHQADRLLGLQCDTAQGWYFHHPVHADVIADLLARELVEPGSLPLELPGSLPNPHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVV3</accession>
    <name>A0A231GVV3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cmk</name>
        <name evidence="10" type="ORF">B7C42_07253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40695">
        <property type="protein sequence ID" value="OXR40695"/>
        <property type="gene ID" value="B7C42_07253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="240" mass="25373" checksum="E5E7D77CBEE98514" modified="2017-10-25" version="1">MVESGIGDGIPGAELVVAMDGPSGTGKSSVSRRLAARLDARYLDTGAMYRVATLRVLRSGVELTDPAEIAAAVKDLPLTIGTDPGHELIELDGEDVSSEIRGDAVTKAVSAVSAVAEVRTQLVALQREIAAAAGRIVVEGRDIGTVVLPDADAKIYLTASAQARAARRNQQNIAEGRGDDYEAVLADVQRRDNLDSTRAVSPLRPAADAVQVDTSELSMDQVIDELYRVVAQQITVGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVX5</accession>
    <name>A0A231GVX5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40728">
        <property type="protein sequence ID" value="OXR40728"/>
        <property type="gene ID" value="B7C42_07152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12050" checksum="7E445DE9721447CB" modified="2017-10-25" version="1">MADPVGYVLAIAAGMDVSAILVPDLDHIDNRAERITAGFDLVTVSPARLWRCGEVGPIAVQSVPLNDCTFEPTQLERDCARRLWEVHRDCFPDCLARLAASAALSALDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWN0</accession>
    <name>A0A231GWN0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative isomerase YddE</fullName>
            <ecNumber evidence="1">5.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yddE</name>
        <name evidence="1" type="ORF">B7C42_06972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41006">
        <property type="protein sequence ID" value="OXR41006"/>
        <property type="gene ID" value="B7C42_06972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="27717" checksum="F5A43360F67D8A1F" modified="2017-10-25" version="1">MPRPGHRAGASCVLLRVRWDNMSQWESDGTQVEVVRVFTDVTGRLGNPLGIVRADAVTEVDHQLLAARIGHSETVVLDDPVSGRTRMRIYTPARELPFAGHPTVGAAWWLADQGHPVKIIDVPAGPVEIQMLDDGLVWIRARAEWAPEFTFDEFSDAAFLDTVDPRHFTDGQHYVWAWTNEARGAVHARMFAPALGIAEDEATGAAAIALTAKLRRSLIITQGAGSQLFTEWDSDGWVRLGGRVVADHPMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWQ0</accession>
    <name>A0A231GWQ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-alanine--pyruvate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bauA</name>
        <name evidence="3" type="ORF">B7C42_06974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.18" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41008">
        <property type="protein sequence ID" value="OXR41008"/>
        <property type="gene ID" value="B7C42_06974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016223">
        <property type="term" value="F:beta-alanine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="43248" checksum="62B5BF77979D1EB6" modified="2017-10-25" version="1">MGSLWHGFADMGAVERDGAFVVARGEGAYIWDEAGRRYLDATAGLWFTNVGHGRREIADAVAAQLSTLAHYSNFGDLTAPVTQRLAERLSELAPVPGSKIMFTSGGSDSVDTAAKLARRFWREQGRPDKTLLVGRRLAYHGMHVAGTALAGIEVNHEGYGELMADTRTVEFDQAQALRTLIDEVGADRIAAFFCEPIIGAGGVYLPPEGYLTEVRRLCRDNDILFVADEVVTGFGRIGGSWFASTRFGLEPDLMTTAKGLTSGYLPMGAVFVAPRVAEPFFGGGVWFRHGYTYGGHAGSAAAAMANLDIIEREHLLDASKNIESLLHEHLAPLAGHPRVAQVRSGLGAVAGVQLADPSEGPAMVKALRAEGVSTRSAGQGALQISPAFVITDEQIAELAAAIGRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWQ3</accession>
    <name>A0A231GWQ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADPH oxidoreductase</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_06814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41044">
        <property type="protein sequence ID" value="OXR41044"/>
        <property type="gene ID" value="B7C42_06814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="308"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="42189" checksum="8D8B2DD30E0D292D" modified="2017-10-25" version="1">MVSKSVQGLRAWLEAPVADAKMAGRTRLDALRGAAARITTPLLPDDYLHLVNPLWSARELRGRIVEVRKETADSVTLVIKPGWGFDFTFTPGQYIGIGVLVDGRWHWRSYSLTCPPDWTAPDNRAERVISIAVKAMPEGFLSSHLVNGVPQGTVVRLAAPQGGFVLPEPPPAKVLFITAGSGITPVMAMLRTMDRRAADRTDGDAMDDIVHIHSARTAEDVMFGAELRALHDKHPGFTAHIHLTGEQGKFDLADLDARFPDWRERETWACGPAGLLNDVEKHWAAAGISDKLHVERFEVERSAVGEGGTVTFARTDRSTEVDGATSLLEAGEAAGVQMPFGCRMGICQTCVVTLTDGHVRDLRNGDEHQAGEKVQTCISAAAGDCTLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWS3</accession>
    <name>A0A231GWS3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41077">
        <property type="protein sequence ID" value="OXR41077"/>
        <property type="gene ID" value="B7C42_06847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="25531" checksum="DDE88BB0780033C0" modified="2017-10-25" version="1">MNTLAMLLLLAADLWMAAAGLYYGARIIRRHRNYLLGLEWLVIGVSGTNVLFLAATGVDHSSVSYHLMVFFDAFSRSFGMTLVFVLGMMAVTRGYRASPLVEAAAFGAATVVGLWRTIDVRPVSPPWSLFYLALNLAVAVFMVTVAGRLWRIGERRCAAGVFIATILGAIVASTYDFVHIPGDDADHTLFYIPACAIWALMVTTYYYGYRALDDHNRRHPRKAAVTVSASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWZ8</accession>
    <name>A0A231GWZ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821381.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41153">
        <property type="protein sequence ID" value="OXR41153"/>
        <property type="gene ID" value="B7C42_06749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025597">
        <property type="entry name" value="DUF4345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14248">
        <property type="entry name" value="DUF4345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="151" mass="15895" checksum="982CF2D4C4C67EE0" modified="2017-10-25" version="1">MRRLLQIWLLVFGLACTGIALTHLVFGTASIIGGGPVNATVDSDMRFYAVVFGAYGLAVAWCARDVERRGPAINALGAVFFAGGLARMLAWAVSGEPNWFYVLMTPVELLIPVLNYVLVRAVCVGRGPDDGRGSGVGSLGVAPAIRREGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX69</accession>
    <name>A0A231GX69_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41172">
        <property type="protein sequence ID" value="OXR41172"/>
        <property type="gene ID" value="B7C42_06768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041458">
        <property type="entry name" value="DUF5593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18007">
        <property type="entry name" value="DUF5593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5593" evidence="1">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="368" mass="41542" checksum="BACF64F56E2B4C24" modified="2017-10-25" version="1">MPDVMTVASVGETPREFASWQRVVQRVLTKMPAVYDSLTTARLADALYSARDRAEEVDLRIPTRAGHHELKLRPVFGPAGDVHGLRLWIGPAAATVAEPRPAVGAIWDLDSQTVQQPSGITRLPGVDVQEYVPRMSIAEVFHRMTAFDRHSEVLDLLYEPKAGAKMQFDVAVPHNSGRPGRWRVTIRARDDDRTRGAWWLIEDVSSDDQPATWSTLERVGLREAHRRAGTHLAVIELEHTSISHWLTDPAPWMRWDYLFRPVDVFHPDDRGRLIELSGRLAAGDTAGVTVRALNYGGGYTPTSMLLYPYPGYSTRQLAIAQLVRVADDVPMMEPHREAFAARHHRVPIGYDDQLQHRLAFRMNRSPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX90</accession>
    <name>A0A231GX90_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41219">
        <property type="protein sequence ID" value="OXR41219"/>
        <property type="gene ID" value="B7C42_06617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="175"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="327"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="43007" checksum="B9086644F50EDAD6" modified="2017-10-25" version="1">MAEDLLARSQEILERLWAASLADPEYRVIADDPGLAEADRRLNTANLRQWLVSNIQRPGLRVPTYASPETLVYARDVVLRGLTTDDLHSWRSGQRVAWHWWLDACFKATSDLAELRELIEVSANSLTTFVDDSIAAMTANIEEVRNELAGGAQLQRYATVELLLQGAPIERPRAEAQLGYALTGKHVAAIIWGDSEEDATRLESAAEQVMRVCGARQRLTVVAGTTAIWLWMPLAAVPPVDDVLARLKGLKGARVAFGRAAPDIAGFRRTHMDAAAAQRLLSRLGSHLRVVRYEDVQLADLLSTNTALADQFISDVLGDLATADPVLHQTTLTFVREGFNRSSTAEQLFTHRNTIDRRLARVDELLPKPLAEDPASVVAALTVLKIKNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXW4</accession>
    <name>A0A231GXW4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.289</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wbbL_1</name>
        <name evidence="2" type="ORF">B7C42_06579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.289" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043015.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41436">
        <property type="protein sequence ID" value="OXR41436"/>
        <property type="gene ID" value="B7C42_06579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102096">
        <property type="term" value="F:decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="33322" checksum="F666690C957A8350" modified="2017-10-25" version="1">MSASDSAPSADRTPQLAVVTVTYSPGEHLDHFISTLATATAEKPQVILADNGSTDGAPELAAESNEHVTLLRTGGNIGYGGAVNRAVAELDPDIEYVIIANPDVRWGTDSIDQLLAAARRWPRAGALGPLIHEPDGSIYPSARRVPGLLDGAGHAILGTIWPGNPWTRRYRQENEEIAERTVGWLSGSCLLVRRDAFDSIEGFDSRYFMYMEDVDFGDRMGKAGWHNVFVPTAEVTHAKGHAAGRHPETMLPAHHASAYRFQADRHPHWWQAPLRWALRAGLAIRCKLAVRSALRERDREAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY63</accession>
    <name>A0A231GY63_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41557">
        <property type="protein sequence ID" value="OXR41557"/>
        <property type="gene ID" value="B7C42_06450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="34119" checksum="E6B78E72BA9B8E23" modified="2017-10-25" version="1">MVDSLFADVSEFQVPVDDSYPYQLFSFRSNDGTYQDHNFYSNYSWAARAADSGRIACFIVYFYWRPNWLDTVDTHRSMVGQAGGPHPKMITMIDVESGGNPGGDQSDGINRAYWRLADWLGSTRRVIGYANRPDFDSMWPVRPDGLNMIGAGYGSNPNLPGQIAHQYTDGQGYGGGLPEGASPFGNCDMNSADGFSPEDFANQVGVGSVATDPVTDMWIQFMGIGGNGWPQLAGHTLVDGVASVGQTLGLPGFAAPPGPTQVPLPRDSDGRIRDEWIQMRGLQGTGWPQLGGWSLVDAIAAIGQKLDIAGFQPPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ7</accession>
    <name>A0A231GYJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-formylbenzenesulfonate dehydrogenase TsaC1/TsaC2</fullName>
            <ecNumber evidence="1">1.2.1.62</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsaC1_2</name>
        <name evidence="1" type="ORF">B7C42_06319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.62" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41678">
        <property type="protein sequence ID" value="OXR41678"/>
        <property type="gene ID" value="B7C42_06319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018482">
        <property type="term" value="F:4-formylbenzenesulfonate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="24801" checksum="7451109C37CD3C49" modified="2017-10-25" version="1">MTDTTHTLVIGGSSGMGLALARRLLPAGHRVTIAARDTDRLSAAAAQLGYPDQISSQRVDIADEASIAALFDTIGAIDHVIVTAADMRHGYGPLTELPAGDARTVLDIKVLGPWLVAKYAAGRVTNSLTVTSGIAAYRPAPGGSVVATANAALEGLVRALALEMAPIRVNAVSPGWVDTPIWDDFAGPDKHARLTAMAARLPAGRIGRPADIAAAFHAVLDNDFLTGEVLHVEGGHRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ53</accession>
    <name>A0A231GZ53_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41855">
        <property type="protein sequence ID" value="OXR41855"/>
        <property type="gene ID" value="B7C42_06197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="13783" checksum="32D2BC9D5B64358B" modified="2017-10-25" version="1">MTPSPAELMRRNLLDVFNEPDPQRRAAVIAESYAEDVVWHETDRKIYGRKDFERRATELLADNPGWTFRTAGPAVELDDIGQLPFDWGPAGEPAVVSGMDIARTANGVIIELYTIVTEIRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZM1</accession>
    <name>A0A231GZM1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42050">
        <property type="protein sequence ID" value="OXR42050"/>
        <property type="gene ID" value="B7C42_06034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012805201" evidence="2">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="217" mass="22130" checksum="F11DFA151F91BCEB" modified="2017-10-25" version="1">MNTRVTLLAAATLAAPLLLCGCSHQDSSPVSQAAHPVSIADQGAPAVGPGPSGTYTVAAQPAPGTCHVGKSADGQPLPDPHCTPGAINPKVTPDTVKSTICVGGYTQSIRPPATITDREKKANAESYGYTGNLHDAEYDHLISLELGGDPNDPRNLWVEPPSPDHKAGSGPNNPKDSVENKLHSLICSGAVGLTDAQNAIAGDWTTALAAVGHPDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZN7</accession>
    <name>A0A231GZN7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42012">
        <property type="protein sequence ID" value="OXR42012"/>
        <property type="gene ID" value="B7C42_05996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="498" mass="54585" checksum="FFC5CFA10A6A6593" modified="2017-10-25" version="1">MEVVEGLHSTVVVVGSGFGGIGMGTALRRAGMDDFVILEESSELGGVWRDNTYPGCNCDVPAHLYSFSFAPYRDTAVRFPGRRRTLEYLRSIAAAEGLPAHLRTGTAVTEATYSESEARWELRTANGIRLTADIVVFAVGQLHRPNIPEIPGRDEFGGASFHTAGWDHAADLRGRRIALIGTGSSAAQCLPTLADTAASVRIFQRTPQWILPKPAPEFGPVTRAALRLPGAQRAHRWGLQQAADSLLAPMMHRRWPARPAEWAARQYLRRSIDDPVLRGRLTPDYPIGAKRIVFDSHFYRTLRRDNVDLTTAAIARITRDGILTADGGRYDADVIVYATGFRASEFLAPITVRGRGGRSLQDRWRSGPDAFMGLAVPGFPNAFLIAGPNSFTPAGSNPTMKEHQIAYIMRCLRWRDEIGAAAIEVRADAMAAHREWLADALATTVWSTDVPSWYTHDSGAITNPWPASVRTYARMLRRPPALSFVPVHHTATAEAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0H2</accession>
    <name>A0A231H0H2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42360">
        <property type="protein sequence ID" value="OXR42360"/>
        <property type="gene ID" value="B7C42_05559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="28904" checksum="09671FF8E86BDA36" modified="2017-10-25" version="1">MQTVTSQDGTTIAFDRIGSGSAGTVVLISGAFGYRQVPNTVELAQALAENYGLRVLNYDRRGRGDSADSPGVYDSANEIADIRALVEAEGGSAALLGWGSGAILALLAARSGAITGITDVVAFEPPFVVDPKDHVPPKDAEEKLRGRIAAGKRGGAVRYYMTKVMGVPELVVAVMRMSSVWKTLVATADSTAHDFAVLEPFSRGRTIQPEDWAMLTQPTLLLIGDRSAPALTKGAKAMVEVLPNAELRELPGVSNDPVAAQLAPAIGEFLTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0I0</accession>
    <name>A0A231H0I0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42328">
        <property type="protein sequence ID" value="OXR42328"/>
        <property type="gene ID" value="B7C42_05527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="19140" checksum="35AB7B369FCA452E" modified="2017-10-25" version="1">MADLAITVEIAEPGIAVGATSFGFFQIREPGPPPHRYRSNLRAVVHGRGVPISDSAYGHGFGAMGVVILEGMASRDPEPIREARTPTARAGWSAADRAAYRRFVRTQHPDVGGDPVAFQEGLARYEAARRAGTRASGVDPTDRFDGPVRFVATPRGWRRAVRVLRPRRRTRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0N7</accession>
    <name>A0A231H0N7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase B</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cysM_2</name>
        <name evidence="4" type="ORF">B7C42_05588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42388">
        <property type="protein sequence ID" value="OXR42388"/>
        <property type="gene ID" value="B7C42_05588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="8"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="348" mass="36629" checksum="7F6E3A0BE6D4AE58" modified="2017-10-25" version="1">MPIVTRVTDLIGNTPLFELAVTAGGTRLLLKLEQFNPTGAAKIRMAREMVLDAERRGLLRDGGHIIESTSGNTGLGLAVVAAERGYRFTAVVDHHACKDKLRAMRAMGADLVYVAAEGDDSLATSAREDLAEAMAAARPDAYFTEQHNNEANPVGYYAVAEELLADLGQVDILLSAVGTGGSLFGTARRLRDLGRPARVIGVEPVGSIAFGGPGGPYWQSGTGTPPGATVGTAVDYSLLDEGVTVSDVDAFATARAVAQRCGLMIGGSAGGSVYVALQRLEEFEPGSTIVTIVCDGGEKYLDTVFDDEWMSDRDLLDRTAEHAVTDLLDRYAPAAPAVSEARNLVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H140</accession>
    <name>A0A231H140_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine catabolism regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pucR_3</name>
        <name evidence="2" type="ORF">B7C42_05346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42569">
        <property type="protein sequence ID" value="OXR42569"/>
        <property type="gene ID" value="B7C42_05346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="384" mass="41521" checksum="91A2D47680D167D4" modified="2017-10-25" version="1">MSDDDGATRPRLRPSAIGDPGAFAEHVCHRLQREIPAYRGIAASALVPSIADAVDRLISATSADRPLDEQELADFRAYGALRAELGVPLDAMLRGWQIVVGEVIERIGTSEHWATRPGAALMSVLAALLRASDAATVAYSSGHREAEAQITRRLDTRRDDMVRALAEGALPAGELRRRAQYIGLRLDGAYAAFRAITDEPEHTEWELRQRPGFRPPRGVVAILDRDVVGICDPHDDSAPSAGVFLGVGPACPLEGVPRSLRVAGRVAETARLFGRAGRHTLTDLGVLPAVVGDSDVGSALLLRYITPLDDAEAGSILDTVDAYIAAGLNASETGHRLYLHHNTVRYRLSRFEELTGASLKDPHVAQQVWWALRYRELNSGAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1P2</accession>
    <name>A0A231H1P2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P) transhydrogenase subunit alpha</fullName>
            <ecNumber evidence="3">1.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pntA_2</name>
        <name evidence="3" type="ORF">B7C42_05099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42761">
        <property type="protein sequence ID" value="OXR42761"/>
        <property type="gene ID" value="B7C42_05099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="1">
        <location>
            <begin position="140"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="35352" checksum="1A51298BF23DF845" modified="2017-10-25" version="1">MIVGVLRETAARERRVALTPDGVRCLIAAGMRVVVEVGAGRAAGFDDDTYRFAGAALVDDPGAVVAACDVLAWVKPATHDLRAMSRRPHLTLIGFQDPLRRAAQIAELRGSGVESIAFELFSHEAGALDALSAMSRIAGSVAYLAGRRLVPRTVRRPIRSLILGCGPAGLSAVAAAAACGAEPPVVLGRRPELREALNAQGPNVFHWSHDVDAARVLERIRTDKPDLVFCAAVRRGQRSPLLVDGPALDALGDGAVVVDLTAKAGGNCAATVTDATVVLGNGVVVTHRSNYPARRPAPASRAYSAAVTAAILRLAECGLPRDQTVSDASASNASATIGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H232</accession>
    <name>A0A231H232_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicyloyl-CoA 5-hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.209</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdgC_2</name>
        <name evidence="2" type="ORF">B7C42_04791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.209" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42905">
        <property type="protein sequence ID" value="OXR42905"/>
        <property type="gene ID" value="B7C42_04791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="552" mass="59923" checksum="455B0F4D4041CA42" modified="2017-10-25" version="1">MELTDNPYAPPPTLRRVACIGGGPGGLFAAIALAHSVPGIEIDVYERNGESDVFGFGVVFSDATADNIDAVDPVLRNALRADGRHWDTIEVHLKGATVAAGGNGMSAIHRRVLLDALRRRATELGARLHFSVETDVAALDARGYDLIVAADGANSTVREQFSSALGHRVDQAAVKFIWFGTTYRFRGLTFLHARSEHGNFAVHGYPIGSGLSTFIVEADEDTWRRAGLDGFDTTAPPGESDEVTQRYLERLFADQIDGHPLVANNSRWANFRTRRTENWYCRTASGTPVVLIGDAVHTAHFSVGSGTKMAMEDAAVLARTIAEHPADPDEALRRFQEIRRPQVAKIQDSSLPSLAWWDHFGEYYGAFEPWQFGFHFFTRAISAEKIRIRDGAFVASAERAWQAKYAAAPLDTPLRIGADTLRSRLLCLTRHSGDRVAVGDGATTVDAHACEGPIRLFTAPVDGTTSLPDASRDDLDTVIAAGPKAVVVQGGTPLSRALCAEHVRLRHGIPVIVIDTPAAVRVRRATDERDCAATLVLSGRADAVAFETREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H237</accession>
    <name>A0A231H237_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxymuconate semialdehyde hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylF_2</name>
        <name evidence="2" type="ORF">B7C42_04794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.9" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42908">
        <property type="protein sequence ID" value="OXR42908"/>
        <property type="gene ID" value="B7C42_04794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018775">
        <property type="term" value="F:2-hydroxymuconate-semialdehyde hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="31151" checksum="D88446468A51344B" modified="2017-10-25" version="1">MTEIHERTVTTNGYSTFLLESGAENPETVILLHGGGPGATASSNWRGFMPLLSEYRVLAPDLVGYGRTDHPDEGPAALLGWLRMRVEQVLALMDALGIARAHLVGNSMGGALAMHLLMAEPGRFQRVSLMGSAGGEAHPTPEVMRMVTFYKDPSMSALENLTTWFVYDEDLLDRSVSSIVAERHREIMRPEVRRSYTRFFSPTSTPAEAAVPPSALRRMPHPFLVVHGREDRFVAPESSVYLQQHLPNAQLHIFEKCGHWVQIEKAQGYAVLLRTFLSGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H257</accession>
    <name>A0A231H257_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenate reductase</fullName>
            <ecNumber evidence="4">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arsC_2</name>
        <name evidence="4" type="ORF">B7C42_04817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778367.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42931">
        <property type="protein sequence ID" value="OXR42931"/>
        <property type="gene ID" value="B7C42_04817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="13701" checksum="BC1162F8CC19B8C1" modified="2017-10-25" version="1">MTSGQTQIWHNPRCSKSRAAKTALDEAGVDYIERRYLDDPPTADDLREVLAQLGLEPWDITRTGEPEAKELGMSGWSRTEADREQWIETLASNPKLIQRPIVVTPDGRAVVARDEQSLKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H289</accession>
    <name>A0A231H289_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518877.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42958">
        <property type="protein sequence ID" value="OXR42958"/>
        <property type="gene ID" value="B7C42_04844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="10821" checksum="0CCE77E76B6F67C5" modified="2017-10-25" version="1">MEALIYGYVRDDLADGHAAELEDAMCTLASEVGLCFAATFHESTQGDGTAFAELTAELKRAEAHHVVVPSLDHLAGQTIPRDMLIAKLAHDAEAQVLTIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2D8</accession>
    <name>A0A231H2D8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778684.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43010">
        <property type="protein sequence ID" value="OXR43010"/>
        <property type="gene ID" value="B7C42_04896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12199" checksum="AD6D3A2FA2C4FA71" modified="2017-10-25" version="1">MTFLALGFLRTEVSRLHQEWDAAQIRCLARRLGYTLSETVAFGDRTDNPVQFLIGAAITHDAEAVIVPSIEHFPGGIVPAELIEVTDVITVRPERTYARWPLGEPPGTGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2K8</accession>
    <name>A0A231H2K8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hemolysin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tlyC</name>
        <name evidence="11" type="ORF">B7C42_04953</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777961.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43067">
        <property type="protein sequence ID" value="OXR43067"/>
        <property type="gene ID" value="B7C42_04953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="291"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="354" mass="38028" checksum="1E3679F38D6423A0" modified="2017-10-25" version="1">MGDLFGLLLTVVLLGANAFFVGAEFALISARRDRLETLAAQGKRGAGTVIGAAEHLSMMLAAAQLGITICSLLLGRIGEPAIAHLLERPFDLVGVPDQLLHPVGFALALGLVVILHMLMGEMIPKNIALAGPERVALLLVPIMLWWLRLARPLIGLYNLAANLTLRALRIEPKDELDATVSSVELAEMIGESRSEGLIDEEEHRRLTQALGTTDRIVADVMVPLAKTRCVPLRGDGTTLGDIESAVAETGFSRYPVRATDGSLVGYLHVKDVLDKVADDSAGPSTPIPRTDIRPLPTLSMGTTLYEALARLRRTNSHLGRVIDTRGNTVGIVALEDLVEEFVGTVRDATHRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2M6</accession>
    <name>A0A231H2M6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43099">
        <property type="protein sequence ID" value="OXR43099"/>
        <property type="gene ID" value="B7C42_04985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="102" mass="11204" checksum="85499D9413F7089D" modified="2017-10-25" version="1">MRDALPVALGWVHPESPCLDWDIAQVRRLAERLGYRLVWAPEASRIPLADQVRAAGAEVVIAPSTEHFDFLALNSVMAVADVETVNPRLSFARWATGGQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2T0</accession>
    <name>A0A231H2T0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribonucleotide transport ATP-binding protein mkl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mkl_4</name>
        <name evidence="5" type="ORF">B7C42_04559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43137">
        <property type="protein sequence ID" value="OXR43137"/>
        <property type="gene ID" value="B7C42_04559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="331" mass="36415" checksum="8042672E69ED6CCB" modified="2017-10-25" version="1">MSGVEVRVEGLTKSFGPQTIWRDVTLTLPPGEVSVLLGPSGTGKSVFLKSLIGLLRPEYGSILIDGTDILECSEKELYEIRKLFGVLFQDGALFGSMTLFDNTAFPLREHTRKPESEIRRIVMEKLDLVGLAGAETKLPGEISGGMRKRAGLARALVLDPQIILVDEPDSGLDPVRTTYISQLFLDINAQIDATFLIVTHNINLARTVPDNIGMLFRRELVMFGPREVLLTSDEPVVRQFLNGRMIGPIGMSEEKDEAQMAHEQALVDAGHHAGGVEDIEGIVAQMQPTPGMPFRQAAARRQERVRAILHTLPAQARRAIENTFEPAELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3A9</accession>
    <name>A0A231H3A9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannosyl-D-glycerate transport/metabolism system repressor MngR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mngR</name>
        <name evidence="5" type="ORF">B7C42_04714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43292">
        <property type="protein sequence ID" value="OXR43292"/>
        <property type="gene ID" value="B7C42_04714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="26198" checksum="BA900E1F03A5AA05" modified="2017-10-25" version="1">MRLRSSIVHGELLAGDVLPTEARLMEEFGVSRPTLREAIRILEAEALISSRRGTRGGAQVTGPDIGVAARYVGLILQLQGTTLADVYEARMISEPACAGLLAERHSEQDLRDLRACVEALSRLGDRGLDSPAAMSEWSELTSRFHRLITERAGNRTLAVQAGVVRDIIDTHHAHAFAKGTRTAAPGKDFQLNLRSLEKLVALIAAGDREGAQRHWTEHMRAAGEGLFRDGSGETTIVDLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3H9</accession>
    <name>A0A231H3H9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carnitine transport ATP-binding protein OpuCA</fullName>
            <ecNumber evidence="6">3.6.3.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">opuCA</name>
        <name evidence="6" type="ORF">B7C42_04258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.32" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778470.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43391">
        <property type="protein sequence ID" value="OXR43391"/>
        <property type="gene ID" value="B7C42_04258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="428" mass="45962" checksum="E2168DF5DA9521B3" modified="2017-10-25" version="1">MTDAVTDRPGPATPERNVTGASIVLDSVVKRYKGQDKPAVARLDLEIEAGQIVAFVGPSGCGKTTTLKMINRLIEPTEGRIFIGGRDVTREDPDKLRQSIGYVIQSGGLFPHWSVRKNVGAIPRVLGWDKKRIAERTEYLLELVGLDPGIFADRLPKDMSGGQQQRVGVARALAADPPVLLMDEPFGAVDPITRVRLQDSLIGIQHELGKTIVVVTHDFEEATKLGDKVLILSEGGHVEQYARPEEILTAPATPFVEEFVGSGAKLAYLTVQRVRDVEWDDVVTARIGEPSQAVIQRARAAGQTWVVVVDAAGRPRSWPSLTELASKPEVSDYLDRRLPVVARSSTLNDALDAMLAASQGAALVTDGRGAVVGSIGIGAVTETIQAALADVRSEEHDTSYETYVDGTDPAPTPVVAADDDEHESAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M4</accession>
    <name>A0A231H3M4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic hydroperoxide resistance transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ohrR_3</name>
        <name evidence="2" type="ORF">B7C42_04311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43444">
        <property type="protein sequence ID" value="OXR43444"/>
        <property type="gene ID" value="B7C42_04311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="17308" checksum="059A9A91ED660098" modified="2017-10-25" version="1">MTDPLALDQQLCFQLYAASRAVTARYRPQLDALGLTYPQYLVMLALWERDGRGVGDLCAALALDSGTLSPLLKRLEAAGFVERRRAAEDERRVEIRLTERGDALRERACDIPARMATAFGGGLSLDELVTLRETLARLTAALNTEPDAEGASTERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4C0</accession>
    <name>A0A231H4C0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036506165.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43701">
        <property type="protein sequence ID" value="OXR43701"/>
        <property type="gene ID" value="B7C42_03936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025350">
        <property type="entry name" value="DUF4254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14063">
        <property type="entry name" value="DUF4254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="16247" checksum="71E1527318EC79C8" modified="2017-10-25" version="1">MESLPPKHLLLEACRGLTYDGHPVLKCACRLSELHEQRLSAAPGPTLDIDRDRAQLVSDIDRWVATELPRAHGGARMHTETVGTVIDRLAQFSALAYLTLTHEPDRVIHDAWRRLSELAVAYDHLAGEVTAGLCRLPDLSGHRDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Y4</accession>
    <name>A0A231H4Y4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505891.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43852">
        <property type="protein sequence ID" value="OXR43852"/>
        <property type="gene ID" value="B7C42_04087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16267" checksum="8A679674A78D66D3" modified="2017-10-25" version="1">MTTITNVSLVTVYVTDQSAAKQWYIDKLGFVETADISMGDNGFRWVTVAQPDHPELEVTLMVPGPPLDETMAEAIRRSLGNGTMGALGLRTEDCQKAYEELTAKGVEFVQPPAERPYGVEAVMRDNSGNWLVLVEQREFDGGAFGPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H505</accession>
    <name>A0A231H505_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mch_1</name>
        <name evidence="6" type="ORF">B7C42_04190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780977.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43951">
        <property type="protein sequence ID" value="OXR43951"/>
        <property type="gene ID" value="B7C42_04190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17738" checksum="809462725123B1D9" modified="2017-10-25" version="1">MEPVRRVVQRGLWFDELEIGVLYEHRPGRTITEADNVAFTTQTMNTQALHLDAAFADGLPPFNQRLVNSMLTLSTLVGLSVTQLTQGTIVGNLGFSEVAFPKPMFHGDTLYAETLVTAKRESKSRPGEGIATFAHTGRNQHGDVVATAVRQTLMRMRPNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H575</accession>
    <name>A0A231H575_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR43990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783859.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43990">
        <property type="protein sequence ID" value="OXR43990"/>
        <property type="gene ID" value="B7C42_03546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="176" mass="20194" checksum="50EDCAA4736E4098" modified="2017-10-25" version="1">MEGQNRPGTIIEHDDRWLLKPLRGHAVSRINWQSDHIELAFDDGNFHILIGYDAELSAKTLAKDSPNRHGINHWSRLQIEEFLAARIVSAVLFKSGAVRLAFKNGWILFIGADSHDYPPEVRFNNRTLWNPTGIVDRSIFDVQPIDPWTGQQVTPPDWPSRPDYLQDRSESDDIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5C8</accession>
    <name>A0A231H5C8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44055">
        <property type="protein sequence ID" value="OXR44055"/>
        <property type="gene ID" value="B7C42_03611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="374" mass="38442" checksum="A0273CC9A98F0C33" modified="2017-10-25" version="1">MFLALRELWYARVRFGLMGGVVALISILTVMLSGLSSGLVDDGVSGLRALPVDAFAFAHGTKTDSAFTRSTIDTAQVAAWRSEPGVADAAPFGNTLVNAKTGGGVAVDFALFGVDPQSFLAPGPAQGTRLDREDGIVVSATALDKGARLGDTVVIDRLGTTLTIVGVTAGKQTFGHVDVAYVPLRTWQQIHAGAKPGEQVRDQAYREASAVALRARPGTTLDLAAGDAAADTTAMTRTASYDASPGFSAEMATMSLIKVFLYAISALVVGAFFLVWTIQRAGELAVLRAIGAPTRFLLADGLTQAVVVLVGATTVGVLIAVGGSRFIHGMPFTLDPAAIATGAVLLVLLGVLGAAAAIVRVTGIDPLTALGAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5F5</accession>
    <name>A0A231H5F5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44183">
        <property type="protein sequence ID" value="OXR44183"/>
        <property type="gene ID" value="B7C42_03743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="78" mass="8801" checksum="BD759C2EDD5F1323" modified="2017-10-25" version="1">MVVQMPQPDMQERYNPYTGKRIVVGLDDPVPAAAALGLEPPRFCEQCGRRMIVQVSPDGWWAKCSRHGVIDSHSLDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5M8</accession>
    <name>A0A231H5M8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44107">
        <property type="protein sequence ID" value="OXR44107"/>
        <property type="gene ID" value="B7C42_03664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="10746" checksum="67018DAA9022FAF9" modified="2017-10-25" version="1">MQSASVARGLQTAGRPIAALAEHVLEIDGVPVTIVIERPEVDRAGIAWRCRVRVVRGNGRLELSQVVGASASAVLRQALDLAGRRLGISEAELLGGADVGGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5W9</accession>
    <name>A0A231H5W9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative endopeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44096">
        <property type="protein sequence ID" value="OXR44096"/>
        <property type="gene ID" value="B7C42_03652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="260"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="379" mass="39362" checksum="0A9AE4E17D2C824D" modified="2017-10-25" version="1">MVSSSGRENGARQAVTAHKGNAQRNNRTRRLVGGSLAVGALVFGASSGGLATADPAPAEQPATAGDAVQRLIELSHQSEQLNQQALAAQGDLEAKQGVARDADAKLTTATQALDAAKAEVRKYQPAVDRTAIAAYQGARTNRLFSVLVSDSPQQLLDQMSTLDVLSTQTSDQLAQFSKATDSATAAETAAKSASDAAQAAAQKADQVRADLEHKRADLQGAMAQVIQAWGALSAGEKSSLAGSLFPPGFDRDTLLRGLVPGSGTSALAAGLTRVGDPYVWGATGPDQFDCSGLVQWAFHHVGIDLPRTSQAQATVGTPVSRESLQPGDVVFFYSDASHVGIYAGNGMILHASTFGVPVAVAPMGNTPFHSARRYWIGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H688</accession>
    <name>A0A231H688_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="2">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acsA_3</name>
        <name evidence="2" type="ORF">B7C42_03143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44355">
        <property type="protein sequence ID" value="OXR44355"/>
        <property type="gene ID" value="B7C42_03143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="13167" checksum="8C58B4BB91BDBDA2" modified="2017-10-25" version="1">MTDTTAEHRDVYPPTAEFAAAANADASIYERATADRDGFWAEQAQRLHWHQPWDRVLDWDDAPFARWFTGGKLNVAYNCVDRHVADGYGDQVAIHWEGEPGDSRSITYAQLQAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6C9</accession>
    <name>A0A231H6C9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">folE</name>
        <name evidence="7" type="ORF">B7C42_03197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497445.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44408">
        <property type="protein sequence ID" value="OXR44408"/>
        <property type="gene ID" value="B7C42_03197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="43"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="23705" checksum="C736C42934513116" modified="2017-10-25" version="1">MSANNSAPAGSDSASGAGAAVVAEAPAPIALGTGRTFDQKRAEAAVRELLVAVGEDPDRPGLIDTPARVARAYLEMFAGLYVEPDSVLNTTFDEGHQELVLVRDIPMYSTCEHHLVSFHGVAHVGYIPGPQGRVTGLSKLARLVDLYAKRPQVQERLTSQIADAVMRKLDPRGAIVVVEAEHLCMAMRGIRKPGASTTTSAVRGLLQTNASSRAEALDLILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6F5</accession>
    <name>A0A231H6F5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44372">
        <property type="protein sequence ID" value="OXR44372"/>
        <property type="gene ID" value="B7C42_03161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="43"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="35146" checksum="3C660BBEE29B68F1" modified="2017-10-25" version="1">MPEMKNATPAAERGSRQGESTGRFQPESTASVGHISGDLLDSALDYAETGLRVFPLAPSRIGGKAPLTSNGFKSGTTDPAVIRRWWGKWPDANVGAAVPAGHIVVDLDLYKGAADVLAALEDRLGPLPDTLTCETGGGGEHRWFTVPDLTFRAPGKGIDLRCAGRGYVVMPPSVHVSGGPYVWRDESAPAAPLPAAWVDELASTRPQSATRTTGLPNPRTVGTAAWLASLPAGAPDEAMRVAIGARTLQTAMRDAAHETARDRVYFCLRLGAEGHPGAQRAVGAIMTAFLREFERRRRVGLARAESQAMALVEFERLVSGAAQRIGGSSCEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6G3</accession>
    <name>A0A231H6G3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pknB_2</name>
        <name evidence="10" type="ORF">B7C42_03169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44380">
        <property type="protein sequence ID" value="OXR44380"/>
        <property type="gene ID" value="B7C42_03169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="200"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="800" mass="88241" checksum="FA7C8E9C6916259A" modified="2017-10-25" version="1">MTDGSGSDSDFGRSTAGLESGAVAAFAAAWESAAPAPAISDYLPDAETLRLDALIALIRVDLRQRWLRRPALTPSGGPEPPRKRLRNYCAEFAELSPDRVPASLVYEEFVIRRHSGERVDPREYLREYPAQAPELSELLNADDLDRSTQRAGADPTAIASTMVSPEGTRTTGDVFAEQETTGSQVARLDSIRVGDCIDDFDLLTGLGSGAFARVFLARQRSLQRLVAVKISADRGTEPQTLAQLDHDYIVRIFDQRLLGEPDPHGDSHSRRLRLLYMQFLPGGTLLDVLRRVRSTPADQRSGRLLLAAVDAAMEEKGEIRPTDSSVRAEIAALSWPETVAWLGRRLAEALAYADEHGVLHRDVKPANVLLTAEAVPKLADFNISFSREVAGANPVAYFGGSLSYMSPEQLEACHPGYRRSADDLDTRSDIYSLGVVLWELLTGAKPFDDSTAGERSDSTALGAMLARRRAGVDSAALQRVPPDCPATLCRVLRTCLAPTRDKRWSNGNELAQQFELCLDARARELVDPAPTSWRFRARRWLVPLVLLAYGTPNVLAAVYNTVHNRTLIIDRMSAPAQQTWWIFTSTVNVVFFPVGIVTVMYLSRYLLTVPRGMRRGREYDSRILARARSDALLFGDRCVVVAFSLWTLSAILFPLVLHFATHELTGQEMVHFVGGLLVCGAMAVAYPFFLVTFYMVRCVYPLFLRHGDISPEDAVHLRRLDRRCNGYLAVAASVPLLAVAGVTFLPLSDTPKIIVAVRVLCVGSIVAFVVAYVLFRALEADLRALERVVDPEHQQTAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6I8</accession>
    <name>A0A231H6I8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mmgC_11</name>
        <name evidence="5" type="ORF">B7C42_03280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44491">
        <property type="protein sequence ID" value="OXR44491"/>
        <property type="gene ID" value="B7C42_03280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="184"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="34784" checksum="5191B19F7896C294" modified="2017-10-25" version="1">MRFALSPEQRDFADSLRKMCDAAGTPAVIRNWSGGGARGGRALIRQLAGAGALGLAVAEEYDGMGAETIDLVVACREFGRAAVPGPVIETAAVLPALLQALDDSGPARRWLPGFAEGESLGTIALSPQTPALDADSADVVLVVDGDKLCTARRGDRIESVDAARRLHTVSPDEVVAQGDSVLAAAETAFDAGALAAAAQLLGAGNAMLATSVAYVIQRHQFGQPIGRYQAIKHHLADAKIGLDMAEPLLYRAALSFDTADRARDVSAAKFACAEAAYRTARIALQVHGAIGYTAECDLSLWLTKVTALRTAWGTADFHRARIAAALRTPVAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H721</accession>
    <name>A0A231H721_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44681">
        <property type="protein sequence ID" value="OXR44681"/>
        <property type="gene ID" value="B7C42_03475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325510" evidence="1">
        <location>
            <begin position="23"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="37724" checksum="895DFA8AED948477" modified="2017-10-25" version="1">MVTLVVAGAVTGGVIAATRGGAAPADIAIVNADTGPAGARIVKALQSEDDTWTVAEPGARTTDHAAVITLPADLSSSLATLATAQPHRAQLTVATNEHADTAAVDDAVAAVTRRIAAAGVDQTLAAVANARGSMQQAAFTSQLLDAGVRTASDAAGQFTGGAQQMLGFLDSAKSGAATLTSQLGQVHSTLDQATNQAENMAGAFDATGLTIGQISAGANAMSTGLDQVLPLLRALPFAADPQLTDIIGKLEALRSIAGQADTQLAGVARLTGSSTDPNTGLGTILRDAASRLTSATAQLDQGAALAGQIPRLADQASTQLQDALRAVTGGVTRMQQISTNLTDQTGKALTALPAHSTSQQSVLATNLSDPVEIVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7E8</accession>
    <name>A0A231H7E8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44710">
        <property type="protein sequence ID" value="OXR44710"/>
        <property type="gene ID" value="B7C42_03504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="15791" checksum="B64F79711D66A9DA" modified="2017-10-25" version="1">MDAQRYRRMVNRLNPLVVGLQRLGIGFGPMQLLTVAGRRSGQPRTFPIAVNELNGGRYIVQAYPRAAWVANVRAAESVTLTRGRTSSTARLVEVPVGQRGDLLRELVGSGPVSVGNRFVTTGLADSATPDGVAAAAERIAVFRVEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7M1</accession>
    <name>A0A231H7M1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator CdhR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdhR_7</name>
        <name evidence="2" type="ORF">B7C42_02789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44835">
        <property type="protein sequence ID" value="OXR44835"/>
        <property type="gene ID" value="B7C42_02789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="209"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="33854" checksum="B8040B050F966E8C" modified="2017-10-25" version="1">MHRVVALVRPVQSTFELGCAVEVFGTQRDGVPQHYEFEVCTEAPGAVPTTAGYAISVSRGLAALDSADTVIIPGWLPVETPLSGPARRALVRAHDRGARLVTICSGVFALARTGLLDGRSATTHWARAGQLAREFPRVRVEPDRLYVDHGDVATSAGAGAGIDLCLHLVRTDHGAAHAALIARHMVMPPHRDGGQVQYAPPSPVEDGFDGLLEWAEARLETSLSVADMAAHLNVSPRTLARRFAEQLGTSPGGWLLERRVARARVLLEDTDLPVDAIAVRVGLGSAVNLRRRFHDQVGTTPGAYRRAFRTPAAGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7M2</accession>
    <name>A0A231H7M2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44790">
        <property type="protein sequence ID" value="OXR44790"/>
        <property type="gene ID" value="B7C42_02744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="14083" checksum="B3CD06CDEF6CE63A" modified="2017-10-25" version="1">MLSADDRFAITDLINLHGHLTDNGDFDGWPALFAEDVVYDVTAMGGGVLVGIPACRDAALALGENNPVAHHVTNIVVNEVADGTVRALSKGFGVLTDGTVGSVTYEDTIQRIGAGWKITHRIVRPRRTPLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H804</accession>
    <name>A0A231H804_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Fatty acid oxidation complex subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fadJ_2</name>
        <name evidence="15" type="ORF">B7C42_03100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45143">
        <property type="protein sequence ID" value="OXR45143"/>
        <property type="gene ID" value="B7C42_03100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="14">
        <location>
            <begin position="321"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="13">
        <location>
            <begin position="502"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR45143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="720" mass="76978" checksum="7B8556D5CF1D2B07" modified="2017-10-25" version="1">MTDNIIRWESGDDGIVVLTIDDPTQSANTMNQAYIESMRATVQRLEAERESISGVVVTSAKKTFFAGGDLNDLIATTKSQAAEFFATAETIKSDLRRLEKLGVPVVAAVNGSALGGGLEIALACHYRVALNDNRIQIGLPEVGLGLLPGGGGLTRTVRMFGIQRALTSVLLQGQRYNPVKAVELGLIDALADSTEELLAKAKSYIEANPSPMQPWDVKGYKIPGGTPATPAFAANLPALPANIRKQTKGANLPAPRAIVSAAVEGSQVDFDTASTIESRYLTELVTGQVSKNMIQAFFFDMQQINSGGSRPEGYPRHTFEKVVVLGAGMMGAGIAHVCAKAGIEVVLRDVSVEAAERGKNYSVRVLDKAIAKGAMTREQADEILARITPTDDAELAVGADLVVEAVFEDPSLKAKVFAEIEPIVAADAVLGSNTSTLPITTLAESVTRPHDFIGLHFFSPVDKMNLLEIIVGERTIDATLAKAIDFAQQIRKTPIVVNDSRGFFTSRVIGKFLDEAVAMVGEGIAPASIEQAGLQAGYPAPPLQLHDELTLTLPRKIREETKAAEIAAGKQWVTHGSEAVIDRMIDDFDRKGRSTGAGFYDYAEGKRAGIWRGLAEHFTVSSYEIPFKDMKERMLFAEAIDTVKCFDEGVLRSVADANIGSVLGIGFPAWTGGVIQYINGYPGGVAGFVARARELAEKYGERFTPTASLVAKAEAGQAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8M4</accession>
    <name>A0A231H8M4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45198">
        <property type="protein sequence ID" value="OXR45198"/>
        <property type="gene ID" value="B7C42_02323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012917938" evidence="1">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="17556" checksum="CE1253C9C4CA67AA" modified="2017-10-25" version="1">MRRARRLVAAVALIAAAAGCSSGPTPAQRPVRAEDELLQGCGPETDAEIANLVHATAVHREGGPTICAWEGDYPGGGIVDITYAWFAQDSLLRDGQVAAALGYRTDHLVVADFGGLIWHDPRDPGSCGVSAADSGTVTYWVQNRSRLATPDPCAAAMNAEKATVKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Z8</accession>
    <name>A0A231H8Z8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ORF">B7C42_02618</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776503.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45493">
        <property type="protein sequence ID" value="OXR45493"/>
        <property type="gene ID" value="B7C42_02618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR45493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="439" mass="47584" checksum="212D723E4BEC0637" modified="2017-10-25" version="1">MLSAFVSAFRTPDLRRKILFTLGLIALYRVGASLPSPGVDYKAIRHCIDVVSGGDNAGIYQLINLFSGGALLQLSVFAIGIMPYITASIIIQLLTVVIPRFEELRKEGQSGQNKMTQYTRYLSVALAILQATGLVALAARGQLLRGCPQDILADTSIFGMIIIVLVMTAGAALVMWFGEQITERGIGNGMSLLIFAGIAARIPSEGKQILDSKGGLIFGLVCVAAFVVIVGVIFVEQGQRRIPVQYAKRVVGRKMYGGSSTYLPLKVNQAGVIPVIFASSLLYLPNLVAQLTQSTNSDSWWQKIIQKYLVNPGNPVYVVIYFALIVFFTYFYVAITFNPEERADEMKKFGGFIPGYRPGKPTADYLNYVLSRITLPGSIYLGAVAVLPNLLLHIGGGGGGSNFLPFGGTSVLIVVSVGLDTVKQIESQLMNRNYEGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H932</accession>
    <name>A0A231H932_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenylalanine-4-hydroxylase</fullName>
            <ecNumber evidence="8">1.14.16.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phhA_1</name>
        <name evidence="8" type="ORF">B7C42_02437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45312">
        <property type="protein sequence ID" value="OXR45312"/>
        <property type="gene ID" value="B7C42_02437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="PTHR11473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="SSF56534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BH4_AAA_HYDROXYL_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="32614" checksum="1BDC0FA9147BE4A8" modified="2017-10-25" version="1">MFTEAQLYSPVTTGSDGDVTVHLSAEHPGVHDPEYRARRNAIAALALAYRAGETLPRIDYTEEEQQVWRIVSAELTRKHRTYASAEVLDGARRLGLPTDHIPQLDEVTAKLVPLTGFRYVPAAGLVPLREFFGSFADRIFHSTQYIRHHSAPLYTPEPDSIHEIIGHANQLASPRFAAIYAEVGAAVARLETEAALKFLADVFWFSMEFGVVREKGEVRCYGAGLLSSFGEIEEFRHARLRPLNIHEMGTATYDITHYQPILYCAESISEIEDVIGGFFATMTDDSAAAELAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9F7</accession>
    <name>A0A231H9F7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45488">
        <property type="protein sequence ID" value="OXR45488"/>
        <property type="gene ID" value="B7C42_02613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="17270" checksum="C9EF7289E3E9990E" modified="2017-10-25" version="1">MVNERLHADMMTVLEGLDEQLRGIAEIQLRRSRLTATASTCEQRIQVTVNADGLLIDTKFADDIADLTYDEIAAGMTAAVQQAAAEVLRQGAELMQPLRERKLQLPKLSEFVEGAPDLGQMMPTAPPAPTRLEDYRDVPPAHPMDGSAHRSMVSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9M5</accession>
    <name>A0A231H9M5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">B7C42_02627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025347225.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45502">
        <property type="protein sequence ID" value="OXR45502"/>
        <property type="gene ID" value="B7C42_02627"/>
    </dbReference>
    <dbReference type="GeneID" id="66718956"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="61" mass="6932" checksum="4853EA8CE6E26179" modified="2017-10-25" version="1">MAKKALVNKAAAKPKFAVRGYTRCQRCGRPRAVYRKFGLCRVCVREMAHRGELPGVHKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Q9</accession>
    <name>A0A231H9Q9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpA_6</name>
        <name evidence="2" type="ORF">B7C42_02696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776425.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45571">
        <property type="protein sequence ID" value="OXR45571"/>
        <property type="gene ID" value="B7C42_02696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011317300" evidence="1">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="342" mass="36366" checksum="643DF1EA340F5BDF" modified="2017-10-25" version="1">MLAATGVLTGVVAGVGATSASAEDPVIASKSLLADPQSPDGSRIEKATYKDDRSIRLYVHSAAMNRTFPVDVQRPADASVPRPTLYLLNGAGGGEDDASWQKKTDIVNGFLSDKNVNVVQPIGGKWSYYTDWLKDDPSLGRNKWKTFFTEELPPLIDGALGTNGVNAIAGLSTSGTSVLNLAIAKPGLYKSVAAYSGCAESSTQVGREAVKLTVNTWGGGDVRNMYGEDDNPAWQDNDPLLHADQLRGANLYISSGNGLPGQWDTLNGPYALPGAYGLGNQLVVGGVIEAATNYCSHDLQAKLDSLNIPATYNFRSSGTHSWGYWHDDFLDSWPVLARGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA35</accession>
    <name>A0A231HA35_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45577">
        <property type="protein sequence ID" value="OXR45577"/>
        <property type="gene ID" value="B7C42_01869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022074">
        <property type="entry name" value="DUF3626"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12294">
        <property type="entry name" value="DUF3626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="125" mass="13693" checksum="8C16757089499982" modified="2017-10-25" version="1">MTDPLDHYIEAHLHGPLSMDSDVEELVLDPSYRNTSIHATAASLPCPLSWHHGYTLGIDHVRAHADYRGASVVDLAEAVAGEHGSLSPRIVGAARSWADSQDLKKVWHYLARFGRTGDTTPRVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA51</accession>
    <name>A0A231HA51_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45607">
        <property type="protein sequence ID" value="OXR45607"/>
        <property type="gene ID" value="B7C42_01899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="4915" checksum="F57E5599E430FA19" modified="2017-10-25" version="1">MVSVLQRAADHPWKAPTAGSSDGPPDHSAAPAGAIDCWALMIESINDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA70</accession>
    <name>A0A231HA70_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45741">
        <property type="protein sequence ID" value="OXR45741"/>
        <property type="gene ID" value="B7C42_02033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="25652" checksum="21228EE03C011D58" modified="2017-10-25" version="1">MGTFSGRSAIVTGGARGIGAAVAAELAKEGLGVVIADLLERDGTATATALGAGAIFRRLDVADEDGWQRVIADAEATFGPLAVLVNNAGIVDFGGVDTEPPTIFRHVLDVNLYGSWLGMHLAGPRLREAGGGVVVNVSSTAGLMGYAGVGAYVASKWGLRGLTKAAALEWGPSNIRVCSVHPGPIRTAMTAGMDESVTAAQPLARFGEPEEVAAMVRFIVSEATFSTGSEFVVDGGATTGQVLNLPAAVGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAB9</accession>
    <name>A0A231HAB9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45779">
        <property type="protein sequence ID" value="OXR45779"/>
        <property type="gene ID" value="B7C42_02071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="130"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="25111" checksum="0D30BB28E439654E" modified="2017-10-25" version="1">MVASGHEDGVERVVGAGDPQGVGWFRFWFAEGRWEWSDEVARMHGYAPGQIEPTTELLLEHKHPDDRDRVEATIVTSVEDHAPFSSRHRIVDTGGTVRDVLVVSEPMLDESGEVIGTQGYYVDLTDSVDQQRRELFEEELPAVIERRAAIEQAKGILMFVYRISAEQAFRVLAWRSQETNVKLQELAAQLVGRLDTMPPVPASTRTRLDHLLLTLRHPGTDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAD8</accession>
    <name>A0A231HAD8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acryloyl-CoA reductase (NADH)</fullName>
            <ecNumber evidence="6">1.3.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acrC_3</name>
        <name evidence="6" type="ORF">B7C42_02091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.95" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45799">
        <property type="protein sequence ID" value="OXR45799"/>
        <property type="gene ID" value="B7C42_02091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="228"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="374" mass="38972" checksum="252A6EAD1193464A" modified="2017-10-25" version="1">MTGQLSQPVADFAEVHDDLRAVARRVLGATAPGEPQDWTPIAASGWPGLEVAAEFDGAGATFAEVAVVLREMGRALTHSPYASVTALTLPALAAVVPNAARDRLLRATAGGAAVPIVVAGGGAAPPWGDSGGFVPFRIERRDDAVYLRGTTEFAADVTAATTLLIPAREPDGSAVLVAVSPGSPGLAVTEQPILDATRTVGAVYADNSRVDAESVWQWTGADPLPVLFERAALATAIDSVGLAEAALDATVTHVRTREQFGRPVGSFQAVKHACANMLVALRIASRLVDDAVAAHVRGAADAWIAVARAKSHACAVAVDIAGKAMQLHGGMGYTWESGIHRYLERATFDRALFGSPADHRAHLAGRYRDPDFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAT9</accession>
    <name>A0A231HAT9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent urate hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.113</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpxO_2</name>
        <name evidence="2" type="ORF">B7C42_02261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.113" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45968">
        <property type="protein sequence ID" value="OXR45968"/>
        <property type="gene ID" value="B7C42_02261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102099">
        <property type="term" value="F:FAD-dependent urate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="10"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="414" mass="44351" checksum="8D01DE84174FC2CB" modified="2017-10-25" version="1">MNTVSRPLHILVSGGGIAGNAVALQLLRAGVAVTVVERATAPRPGGQAVDLRGPSREVAERMGLMPGIAEYQLEELGISYIDHKGRNYANMSMEHFEGKGPVAEIEITRGDLNQILLDAVAAAGGELDYRYGDWIESLTQDDTGVAVEFASGRSGRFDLVVGADGVHSATRRLAFGPEEQFSTFLGGYASFFTMPTPERVTPGWFAMQLVPSAAVGLRPDRDPATAKAILTLLGEPDPALRRDTAAQQRLIHEKIGSQPHWHAPAILAAMTEADDFYFDELARIDMPTLAAGRVTLVGDAGYCGSPMTGMGTAMALVGAYILAGELAADPGDVPAALRRYEEKVTPFLDKAKELPGGGIEMMLSPSDFGTSLRRTANRIMMSKPMRPVMMKLFFGKTDEYELPTYAASTAVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAZ0</accession>
    <name>A0A231HAZ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_01003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781336.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46040">
        <property type="protein sequence ID" value="OXR46040"/>
        <property type="gene ID" value="B7C42_01003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="8651" checksum="AF7008AD9B4357D0" modified="2017-10-25" version="1">MTFVAIVAGVLLAAAAAFTSFRVLAGPGTLDRVVGIDSLVGIAAAGLAVWAAYSDDTTVVPGIVALSLVGFLGSAAVTRFRVRDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB32</accession>
    <name>A0A231HB32_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetracycline repressor protein class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tetR_4</name>
        <name evidence="9" type="ORF">B7C42_01024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781356.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46061">
        <property type="protein sequence ID" value="OXR46061"/>
        <property type="gene ID" value="B7C42_01024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="213" mass="23637" checksum="827A74BF08513A4D" modified="2017-10-25" version="1">MKLDANAIGAAALELLDETGLDGLTMRKVASALDVQAPALYWHVKNKQELLDVMARAVFAAAVDRVEGPRRGETWQDWIAELAGRLRSSMLRHRDGGRLLAGTYVSDESMWRTMELTLRTLEDAGFSADEAGWVFPIVLHYTVGFVIEEQARTGADYGADNPYAHIDRAVDPDRYPRTANLVTKLSAVDPNDEFDHGVRVILTGIRTLANIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB59</accession>
    <name>A0A231HB59_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anhydrotetracycline monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">otcC_1</name>
        <name evidence="2" type="ORF">B7C42_01025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.38" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46062">
        <property type="protein sequence ID" value="OXR46062"/>
        <property type="gene ID" value="B7C42_01025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047670">
        <property type="term" value="F:anhydrotetracycline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="492" mass="53353" checksum="820F1D41E73A81BD" modified="2017-10-25" version="1">MHTTDVVVAGGGPTGLMLAYELRLAGVAVEVLDALPARTGESRAGGIHARTMEILDQRGLLDDLLRRGRTLPRGHFGGLPLDFGDFHTRFPYTLAVLQSVIEGELDRHATAAGAPVQWDSPVNGFRQDDSGVEVEVGGSRPRRIRAAYLAGCDGGRSAVRKLAGIGFDGTDATVTGMIADVELATPPAELFFGARGATGDYSVIQFEPGWYRLIAQCHDRVRERGTALTFDEFRDAFTELAGTDFGMHRPRWVTHYGDAARQADRYRVGRVFLAGDAAHIHFPAGGQGQNLGLQDAVNLGWKIAAVLRGNASDALLDTYESERHPIAARVLRNTRAQTALSRPGAHVDALRDSMSDLFEIDEVRHRLGLMITALDIRYDCGDEHPLCGRRVPDVDIATADGPTRVHELLRSGRPILLVRNAAEVPDIRAWKDRVEIVCATDPATEWIVPGFGSVPAPVYTLIRPDGYIAWAASTSTTEGLSTALGRWVGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB60</accession>
    <name>A0A231HB60_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B7C42_01032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46069">
        <property type="protein sequence ID" value="OXR46069"/>
        <property type="gene ID" value="B7C42_01032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="83"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="652" mass="68769" checksum="30772056B9D8B853" modified="2017-10-25" version="1">MTTTLLRPMSPTASAASPDADRHRWERPALTVLLLTTTIAYLCNLSANGWANAFYAAAAQAGSVSWKAFLFGSSDAANAITVDKTPAALWPMDLAVRAFGLSSWSLLVPQVLMGVGAVALLWATVRRPFGPVAGLLAGTVLAVTPVAALMFRFDNPDALLVLLMVAACWAMTRALENGRLRWLILCGAFAGFGFLAKQLQVLLVVPALATTYLIAGPPRLGKRIAQLGAAAAAMVAAAGWWILLAEVWPADSRPYFGGSQHNSVLELTFGYNGLGRLNGEEVGSLGPPGGGFRGESGMTRLFQPAQGGQIAWLLPAALILLVAAIVLRGRASRTDPQRAALVLWGGWLVVTALVFSFMRGIFHQYYTVALAPAIAALVGAGIAMLWRHRERTRVRVVATVTMATTTATAWMLLSRNLEFVPWLRWLVLVGGIVVTVALLFPAPRRIAVALAIAAGVAGVAGPLAYTVDTLATAHTGPIPSAGPRMPMRFPAGMRMPWEQSSGAEGFGRAGDHGGRAGGLAAGPWGRDHPGGNAMQVSTPSETLTAILDRDGEAYQWVAATVSSNRAAGYQLATQLPVMAIGGFNGSDPSPTLDQFRDHVAALDIHYFVDGADRGPGGGAEDSTAVRITAWVRNHFTAQNVDGVTIYDLTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBB9</accession>
    <name>A0A231HBB9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Starvation-sensing protein RspB</fullName>
            <ecNumber evidence="6">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rspB</name>
        <name evidence="6" type="ORF">B7C42_01113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46148">
        <property type="protein sequence ID" value="OXR46148"/>
        <property type="gene ID" value="B7C42_01113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="5">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="4">
        <location>
            <begin position="174"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="386" mass="41342" checksum="5B76B04FECF70731" modified="2017-10-25" version="1">MKAVVCSEGKLEVADIPAPKPGPGQLVIAVSRCGICGSDLHARLHCDELAELAAVTGYPNFMRSHQRVVLGHEFVGEIVEYGPGCRKRWRPGTRVVALPIVRNGRTPELTGLSEQAPGGYAEQVVVQESMTFPVPNGLATDHAALTEPMAVAWHAVRKGRVGRNQPAFVVGCGPIGLAVISMLSAAGVKNIVASDFSSRRRELARRCGANVVVDPNLESPWTANPAKSRISGVTDILNLGFDTMTRLRSIPKLPWWYLFRLAHSLDAAPGGPVVFECVGVPGIIDRLLTDAPPLTRIVVVGVCMETDRFRPAMAINKEIELRFAFGYDPGEFRDTLHMIADGKVDPAPLITGTVGLAGVDNAFTALGSPEQHAKILVDPSSSLIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC06</accession>
    <name>A0A231HC06_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">crgA</name>
        <name evidence="4" type="ORF">B7C42_01443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030516702.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46474">
        <property type="protein sequence ID" value="OXR46474"/>
        <property type="gene ID" value="B7C42_01443"/>
    </dbReference>
    <dbReference type="GeneID" id="66718132"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="9964" checksum="302C2E6367B0F70C" modified="2017-10-25" version="1">MPKSKVRKKTDYTINPTSRTPVKVKGGPSPVWYVAIMLGFMLAGLAWLLVYYLGADHIQWMSDLNAWNFLIGFGLMVIGLIMTMRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCB7</accession>
    <name>A0A231HCB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid protease GluP</fullName>
            <ecNumber evidence="7">3.4.21.105</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gluP</name>
        <name evidence="7" type="ORF">B7C42_01441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46472">
        <property type="protein sequence ID" value="OXR46472"/>
        <property type="gene ID" value="B7C42_01441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="116"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="30645" checksum="E46FFD211254E0A3" modified="2017-10-25" version="1">MNPQPPAPTCYRHPDRTTGLACTRCGRPACPQCLQPAAVGQHCAECVAQGRSDIRPGRPAVTGPFATARRTPYVTYALIAINVAVFAVTASQAHSVTDNHLSQLFYDWVLAPQWVAQGQWIRVLGSGFLHYGPLHLVVNMFALYILGRDTELVLGRSRFLAIYLVSLLGGSAAVMWLATDSATAGASGAIYGLFGAMTVILLRLRQSPVQMLVLIAINLLISVSLPGISLWGHLGGLVAGTLAAAGILFLPEWLRARTRDSIRWIGWGSVAGLAVLTIALIGAGAAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCE0</accession>
    <name>A0A231HCE0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_01459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46489">
        <property type="protein sequence ID" value="OXR46489"/>
        <property type="gene ID" value="B7C42_01459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="29352" checksum="7DA42C0322863CEC" modified="2017-10-25" version="1">MADFTTGEAVSLQLPIARIPTRAAAFAIDLVLQLVLALLLLSAVVGVLFRFEPDGAWVDVAVLVTMVTVLVGYPVVSETLTRGRTVGKMALGLRVVRGDGGPVDFRHALIRGLAGALVDFWNLGGFGLVAVVTSLCSPRARRVGDILAGTVVVSDRARIPVPALAVAPPWLVDWVGRLDLSGLTEDLALPVRRYLTRFPQLTPQVQAELGAALVAAVCAQLRVAPPAGYPPLQILGAVIGERQRRILPPPRLPFWPMPQQWAAPAQPYAPAVRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCP5</accession>
    <name>A0A231HCP5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 6">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rmlA</name>
        <name evidence="8" type="ORF">B7C42_01570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497044.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46599">
        <property type="protein sequence ID" value="OXR46599"/>
        <property type="gene ID" value="B7C42_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="32590" checksum="47036A45079A5838" modified="2017-10-25" version="1">MRGIILAGGTGSRLHPITRGVSKQLVPVYDKPMVYYPLSTLMLAGIRDILVITTPEDAGAFRRLLGDGTQFGLAIDYVVQPEPDGLARAFVLGADHIGGECAALVLGDNIFHGPGLGTRLRRFDGLDGGAVFAYRVSDPSAYGVIEFDRGRAVSIEEKPKLPRSNYAIPGLYFYDNDVVEIARGLRPSARGEYEITDINRTYLEQGRLQVETLARGTAWLDTGTFDSLLDAANYVRTIEERQGLKIGVPEEVAWRMGFIDDEQLCRLAEPLVRSGYGTYLLDLLNRGRDDRYGQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCZ9</accession>
    <name>A0A231HCZ9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775467.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46801">
        <property type="protein sequence ID" value="OXR46801"/>
        <property type="gene ID" value="B7C42_01779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="117" mass="12845" checksum="213FDB78A921499A" modified="2017-10-25" version="1">MSISLAAVTFDCRDAATLANFYAQLLERPVDPDANEYFASIGRGEDSGTALMFIRVPDKTPGKNVVHLDLSAPDWRAQIERAVSLGAEHIGDFDEFGVQWVTLADPEGNLFDIAHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDK6</accession>
    <name>A0A231HDK6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan endopeptidase RipA</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ripA_1</name>
        <name evidence="4" type="ORF">B7C42_00100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46984">
        <property type="protein sequence ID" value="OXR46984"/>
        <property type="gene ID" value="B7C42_00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="326"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="450" mass="45997" checksum="6569C71ECA81D23B" modified="2017-10-25" version="1">MSDPISVIATIVASTTGAVDNSGLGSDATTWAHVAVQSGGDTAKSFAVQLDNAVVQLPEPAQQAARQSIAAASDRIASLVPPNVAVPQANTATSPSGPRPGIGDSRVPSQQGAAQADRSSSSGDVQYAAGPEGFASVPVSPAATAPPLTAGGDVATFVPWLKEAGRLCPGIKAPTLAALYAAENGFRYGPTAPVSTAGALGPGQFMPATWAVYGKDVHGTGVPDVFDVGDSVMASGHLLCDTYQQIQQWKLTGLVTGDTLDLTIAAYNAGAGAVLQSGGMPSGSPDYEYQTKPYVARIRATEKQYDWLLATEDGLLPAAQNLPPGEDVGRRIIEQALRYLGLPYVWGGGSSAGPSMGGFDCSGLTSFAVHAGTGGAMTLPRTSQGQWNIGTEIPLSEAAPGDLLFGNWGPDGPGHVAIYLGNGRMIQAPTTGDVVRISPIMSGMRVRRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE62</accession>
    <name>A0A231HE62_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ferredoxin/ferredoxin--NADP reductase</fullName>
            <ecNumber evidence="5">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fprB_1</name>
        <name evidence="5" type="ORF">B7C42_00385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47263">
        <property type="protein sequence ID" value="OXR47263"/>
        <property type="gene ID" value="B7C42_00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="527" mass="56583" checksum="D97BA799CD088B2E" modified="2017-10-25" version="1">MPYVVTQSCCSDASCVYACPVNCIHPTPDEPDFLTAEMLYVDPAACVDCGACATACPVDAITSSKKLTAEQKPFIEINADFYRQARPRPLLAKPVPAAEVDTDRGAMRVAIVGSGPSAMYAADELLTQPDVTVTVFDRLPVPYGLARHGVAPDHTRTRQVSRLFDVISAQPGFGSYLNVAVGDDISHAELLDHFDAVIYAVGASSDRKLGIPGEGLPGSLSATEFVAWYNGHPDYAQRSFDLTQRRAVIVGNGNVALDVARILTMDPELLDATEVSPAALDALRHSKIEEVVIVGRRGPAESAFTVPEFVGLLGSDLDIVVEGEVPEPTPDMPQKVEQKLKLLRSVADRPVGARKRIVFRYLSSPVALVGADRVTGIELVRNDLVTDEAGITRAVATEETETLDTALVLASVGYRGVAVPGVPFDERAGVIPNADGRVLESADGAVVPGTYVTGWIKRGPTGFIGTNKSCAQQTVRQLVDDFNAGRLRRPTADAADFDRLVQRRRPDAVRGGSTAQPWWKRKLLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEA6</accession>
    <name>A0A231HEA6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-(Acetamidomethylene)succinate hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.29" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47313">
        <property type="protein sequence ID" value="OXR47313"/>
        <property type="gene ID" value="B7C42_00435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047411">
        <property type="term" value="F:2-(acetamidomethylene)succinate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="275" mass="29013" checksum="A505CC69F33E7208" modified="2017-10-25" version="1">MRSTSFHRSGTVLTAEIVDGDGPPLVIVPGVMSDAATWRPVVERLGLPNPVVTINRRGRVPSGPLGPDYSVRTEVDDLHHILDALGGAVELFGWSYGGLIALEAACERPDLRSLIAYEPVSAPFAPAAIPALRAAVDRGDLDAAVGLVNTDVSGFSAEYVAALRESPAWAVLRPLAAPLPTELEAINVYPANLQRYRALTVPVTLLLGELNANAEPYGTAFDRIADALPQARIDLLPGQGHLAHAQAPQLLARHIAATVGARTGQEPEEIGSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEK5</accession>
    <name>A0A231HEK5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47360">
        <property type="protein sequence ID" value="OXR47360"/>
        <property type="gene ID" value="B7C42_00483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="32164" checksum="0EB5C0B171B294D3" modified="2017-10-25" version="1">MVRIGLYIGGTAPVTEVVEQIRWAERAGLDSVFLNQVLGWDALTVAALALRETTEIEVGTAVTHTFARHPIALAQQALTATALAPNRFTLGIGPSHPHIVEDAYGLSYERPARHVREYLSALTPLLRGETIDYRGETLRAAGAIDVAGATPPSVVVSALGPAMLKVAGELADGSVTTWTTPGIITEHIAPRLAAAAAAAGRPTPRTVVVVSAAVTHHPDDLRQELAQALAPASRLPSYRALLDRQHLAGVHETALLGPEDVVAEGISAYARAGVTDLIVSVRGDAAAQQRTRELVSAVRRAAPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HER8</accession>
    <name>A0A231HER8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmA</name>
        <name evidence="7" type="ORF">B7C42_00289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025352062.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47167">
        <property type="protein sequence ID" value="OXR47167"/>
        <property type="gene ID" value="B7C42_00289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9278" checksum="B5EAB1271BEC7066" modified="2017-10-25" version="1">MAHKKGASSSRNGRDSNAQRLGVKRFGGQAVKAGEILVRQRGTHFHPGVNVGRGGDDTLFALEAGAVQFGTKRGRKTVNIVVPEPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF24</accession>
    <name>A0A231HF24_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47474">
        <property type="protein sequence ID" value="OXR47474"/>
        <property type="gene ID" value="B7C42_00599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="36127" checksum="35E2A9AF1AF82387" modified="2017-10-25" version="1">MIHDSGCAEIRCGAARHTGAGGLHRRRDVVSVGVSDDEIRRRCAIGSWRRVRRGAYAEASALAELDGVARHRLAVAALLPEMAADAVVSHQSAAVLLGAPMSPALLDRVHVTRNRRHGGRIKPNLTVHCAPVPVVAERDGLLVTSPARTVVDLARTLPFESAVVVGDALAREFGITAAALARELARARGRRGVDGARHVIGFLDPRSAGVDHSRVRVLLRLLGFPPAAAGGVIHADDGRVLGTADLYLGRTGVVLEIDGHRTRAARVHGGPSRRAPDMVLRRYGFRSIRTTWRELSTGVAAERVHAALSRAREQRPRGYIRPAPLPAPRPLRLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF78</accession>
    <name>A0A231HF78_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xanthine dehydrogenase subunit A</fullName>
            <ecNumber evidence="3">1.17.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pucA_1</name>
        <name evidence="3" type="ORF">B7C42_00468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47345">
        <property type="protein sequence ID" value="OXR47345"/>
        <property type="gene ID" value="B7C42_00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="186"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="355" mass="37892" checksum="696DD1713E29F290" modified="2017-10-25" version="1">MRELGEHLRHWHAAATTYALATVIGVRGSAPRAVGTTMAVSASGQVRGSLSGGCVEGAVYEECLRVLESGAPVQHTFGYSADDAFAVGLTCGGELDVFIHRVTAAEYDTIDATLDPERPVALVRDLESGAMVAVRADRTVGGPADPAVIAHARAMLETATSAVRTIGCADRERTVFVASFAPPPRMIVFGATDFTTALCRVGRLLGYRVTVCEPRPVFADRARLPEADEVVRDRPDRYLAGTQVDSRTVICVLTHDPKFDVPVLAAALRLPVAYVGAMGSRRSDRERREHLRDNGITDRQLRRLHSPIGLELGGRTPEETAVSIGAEIVAVRRGGSAQPLSATERPIHADPGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFC4</accession>
    <name>A0A231HFC4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative competence-damage inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cinA_2</name>
        <name evidence="2" type="ORF">B7C42_00808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47683">
        <property type="protein sequence ID" value="OXR47683"/>
        <property type="gene ID" value="B7C42_00808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="18284" checksum="1B1FDA0EF9CE143C" modified="2017-10-25" version="1">MGAAGRAAVTALGTDVAAADPLSAAPEAVELVTTLTRIGQTVATAESLTAGLLAATIAGVPGASVVLRGGLIVYATDLKHHLAGVSEHTLAADGPVAAGTAEQLAVGARTECRADWGIGLTGVAGPDAQNGCPVGTVFLGLSGPGGTEVMRLQLAGDRWTIRMNAVRTAVAELLRRVGGGDPNGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFF6</accession>
    <name>A0A231HFF6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate transporter CysZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysZ</name>
        <name evidence="2" type="ORF">B7C42_00737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47612">
        <property type="protein sequence ID" value="OXR47612"/>
        <property type="gene ID" value="B7C42_00737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="27426" checksum="47F7223BA171754F" modified="2017-10-25" version="1">MVRGFGYLVRGQRWAAAHRRELGLGLLPGVLSMVLYLGLLVALVWFAGDLVAWATPFAAHWSSPWPGLLRGGLAVLLVLLGLFLAVITFTAVTLVIGQPFYEAVSERVDRSLSADGRAPESGLPPWREVWIGVRDGVRILIRAAVWGVVLFCAGFLPLVGQTAVPVLGVCVAGFFLAQELTAVAMLRRGIELREHLTMLRSHRMLVWGFGIPLAAAFLVPFVAIVLMPGAVAGATMLARELCGADTDPAPNPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFI8</accession>
    <name>A0A231HFI8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_00868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47743">
        <property type="protein sequence ID" value="OXR47743"/>
        <property type="gene ID" value="B7C42_00868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041485">
        <property type="entry name" value="TetR_C_36"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18598">
        <property type="entry name" value="TetR_C_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20009" checksum="172BF4AB50D1EE41" modified="2017-10-25" version="1">MIATSEGRRAVDAATKLYLAGEQLDMSVLARELGIGRATLYRHVGNRDDLIATVLAEATERTYRKVFADATGSGAALVLDTLERVMNAVAESEPLRILTSREPALFIRLALLPGRIESTSARMVAELLDSEQRQGNLALPLAADVLGEAIVRICDAHLYAPLLGGDRPRIDTALAIVALLLGQHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFU9</accession>
    <name>A0A231HFU9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactam-inducible penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pbp</name>
        <name evidence="4" type="ORF">B7C42_00721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47596">
        <property type="protein sequence ID" value="OXR47596"/>
        <property type="gene ID" value="B7C42_00721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371116" evidence="1">
        <location>
            <begin position="42"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="3">
        <location>
            <begin position="38"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="330"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="606" mass="63280" checksum="99573405E213229A" modified="2017-10-25" version="1">MSKSRCAPRAWAPRALVLSAAAAVVMTAGACSSGPQGPVAAADSFLAAFARQDPADAADLTTQPEKASAALASAWQNLQAQHLTAHTGSARVTGDTATVDYTYEWTLPKDRVWTYSGQLQMGRSGGQWKVRWSASDIHPKLGDTQSLHLRTTPAPRARVNERSGSDVLIPGVVHRISFTVSDAPDPGYVAGALSAGLKQFDDSLTSDAILAAARKQHGPALVLGLSDWEFDQVSGQLLGLPGVTTDRQWDLIPTDRHFAPDLMTQIRKTVIDEVDGKAGWSVVTVNADGVDTDVLKEVAPQPAPSFSLSIDRTVQNAAQRAVDPRREQTMMVVIQPSTGAILAVAQNEAADTDGPVATTGLYPPGSTFKTVTAAAAMTADIANPDTVVPCPSRIVVGERTIPNYDEFSLGDVPMSTAYERSCNTAFAKLASELPGTALTDAAARMGVGPDYTVAGLPTVSGSVPRADDEVVRTEDGIGQGKVVVSPFGMALVAATVAHGSAPTPYLISGHETAVHGDRPSLSPQVVQGLQAMMRKVVTGGTAERIADQGEVFGKTGEAEVDGGSHSWFIGYRGDLAWATLLVRGGSSDNAVAVTRDMLAALPPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG37</accession>
    <name>A0A231HG37_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5-aminovalerate aminotransferase DavT</fullName>
            <ecNumber evidence="3">2.6.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">davT</name>
        <name evidence="3" type="ORF">B7C42_00780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.48" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779549.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47655">
        <property type="protein sequence ID" value="OXR47655"/>
        <property type="gene ID" value="B7C42_00780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047589">
        <property type="term" value="F:5-aminovalerate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="413" mass="43450" checksum="488736567EF2C4B7" modified="2017-10-25" version="1">MTALSPVLRQATPVTVDHGEGCYLYGTDGRRYLDFTAGIGVTSTGHCHPRVVEAAREQIGSLIHGQYTTVMHRPLLRLTERLADVLPAHLDSVFFANSGSEAVEAALRLARQATGRPNVVVFHGGFHGRTVAAATMTTSGTRFSAGFSPLMGGVHVAPFPTAYRYGWSEEEATDFALRELDYILATLTAPAETAAFVVEPVLGEGGYIPGNTRFFQGLRERADRHGILLIFDEIQTGFGRTGKFFGHQHFDVRADVITIAKGLASGFPLSGIAAPQELMAQAWPGSQGGTYGGNAVACAAAVATIDVIESEGLVDNAAARGTQLLAGARTAATKAIGDVRGLGLLVGSEFTTATGEPDTATAAAAQQLAAQRGLLLLTCGAYSNVVRMIPPLIVTAEQVDEALALWNGVLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG49</accession>
    <name>A0A231HG49_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Soluble epoxide hydrolase</fullName>
            <ecNumber evidence="2">3.3.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042839.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47852">
        <property type="protein sequence ID" value="OXR47852"/>
        <property type="gene ID" value="B7C42_00977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="30636" checksum="CD7F189492F942D9" modified="2017-10-25" version="1">MGTELRFGYADTSFGQLHYAEQGEGPTLLLLHQTPRSWDEFRELMPLLAGEYRVLAMDMVGFGASAKLPAPQTIELYARGACELLDALGVQHAAVLGHHTGAAVALEMAVTAGERVVALLLSSCPWTDERYRGNHAAAGGVDRAERNESGTHLRTLWDLRRPYYPAPVAGLLDRFIRDALAFGVDPAEGHRACARYRMEDRIGAVTAPVLLIGAEKDPFSMPNLPVLSDRLVAARSVRRAVVDNGTVALLEREASAVASVVRDFLASAEITWPDVNTVEPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSJ0</accession>
    <name>A0A231GSJ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000691">
        <property type="protein sequence ID" value="OXR39538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39538">
        <property type="protein sequence ID" value="OXR39538"/>
        <property type="gene ID" value="B7C42_08394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="50" mass="5410" checksum="3C73CC8BBB07752A" modified="2017-10-25" version="1">MRHRAPSPTAGVHRAGLPDFTSSDVGVTPTPKAVHSDPSDTRRSVKRYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT35</accession>
    <name>A0A231GT35_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000074">
        <property type="protein sequence ID" value="OXR39742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39742">
        <property type="protein sequence ID" value="OXR39742"/>
        <property type="gene ID" value="B7C42_08181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="18256" checksum="D17768AE4D9C0E9B" modified="2017-10-25" version="1">MFALADAAVETTDGALTLLWNTLAWGTGRGARNNRRRIAAIASDRDAYAALLLEAAQVSRSDAVAAYALLRPSPYRNAVRWLGPAFFTKFLYFAGGGRPDHPCCILDYRVAAALRAAGWSGLADSGWSAQVYGRYMRLVRSWRDECDCTRVDLIERWLFDTGAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTG9</accession>
    <name>A0A231GTG9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042674.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39882">
        <property type="protein sequence ID" value="OXR39882"/>
        <property type="gene ID" value="B7C42_08057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="331"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="452" mass="47911" checksum="F03CAC95489AFA42" modified="2017-10-25" version="1">MFRAVEAMSRAHALAAAAAARGLTAEQLQRFTSEVGYYRIALDHLTAQLSGPQRDRLRALTDSHDWHTTIAAEDALIAAAPGTSTAGDATSEAAAHVTSGLLELWRAQNAAAGKSAQDAGDRISHGSILAAFAAVAIAVIAVSAALVAADRLARRLVRLRTDTTDLAERRLPALMSRLRRGEQVQIDQEVVRLDPGADEIGDVAAAFNQAQFAAVSAAAAEAATRNGVRAVFVNIAHRSQLVVHRQLEVLDRAEREADDPNYLQTLFALDHLATRARRNAENLIILGGERPARRWRNPVSLFDIVRSAAAETTDYQRMDLTRLPDVRVAGHVVADVVHLLAELMDNATAFSPPQSRVRVDGRAVDGGVRLSVSDQGLGMEPAALAQSNELLAAAPDFGIAALTGDFRLGLFVVAALAGQHGLAVRLTESEYGGISAVVSIPATLLSPAEAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTN1</accession>
    <name>A0A231GTN1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-CoA--L-malate CoA-transferase alpha subunit</fullName>
            <ecNumber evidence="1">2.8.3.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smtA_2</name>
        <name evidence="1" type="ORF">B7C42_07935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.22" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39984">
        <property type="protein sequence ID" value="OXR39984"/>
        <property type="gene ID" value="B7C42_07935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="42944" checksum="88346881856B18E6" modified="2017-10-25" version="1">MNDSLPLAGIRVLELGNYIAAPTAGRLLADFGAEVIKVERPKTGDELRRWRLYAGTTSMLFHTINRNKKSIVLDLRTDEGRRDVVKLAGKCDVVLENFRPGTLEKWGIGPEKLTEANPALIIVRVSAFGQTGPMSSRPGFAAVAEAYGGLRELVGDPDRPPVRTGVSIGDSIAGLYAGFGAMLALFQRAKDPGTPIPLSDRIIDVALNESIFSVMESLVPDYLAYGVERRRVGGRMEGIAPSNAYLCRDGKSIVIAGNSDAIFQRYMYAIERPDLAADPNLTTNDGRWRRRDELDQAIGAWTSRHSRDAALKILDDAGVPSGPIFTAADIAADDQYAARNMIQYLPVDTGTGEPERIGFPGVVPVIGGQSVRIRSVGPELGEHTGEIRAHYLDGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTX7</accession>
    <name>A0A231GTX7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TraG-D_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043598.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40069">
        <property type="protein sequence ID" value="OXR40069"/>
        <property type="gene ID" value="B7C42_07873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="3">
        <location>
            <begin position="441"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="619" mass="66822" checksum="8D6773B9A7665177" modified="2017-10-25" version="1">MARQTRRRTTGGVGEETWLLLIALGVIAVALLAWGALSAGSWCAGLPITAHPVAALLQVMEGQHRWPWQSSAILATALAVVGALAVVCRQRWASVRRSDIDRAARTMVSPRHISAARQQDNATAGERLLKDAPAEVRALPGPPLGRTVVGGVELFVPAEMGVFIAAGQRTGKTMAWAIPAVLSAWGPVMATSNKPDLYRHTVFGREQRGRIWLCDLQAVTGRPVCGFWVDLLARVRTLASARKLASFFVSGASGSASERANARVDSYFDGGAQELLSLYLLAAACVDGDLLHVAEWLSSDQDQTPILILRHHNHVRAAQRILDAQGLYARQRDGLYDMARRFLNVLSDERYATMITPPARKRVTVYETSESIVIDTALAPATHNLPEFKPAEFITSNDTLYALSMTGPDSAAALTAALVGQILESALACARARLDGRLAVPLLAVLDEAANCALIDALPSYYTYAAGCGVILLTIVQVLEQAEDLWGTNGLTVIRAQSIEIYGGNIATPAYLEQWARLVDDHDVADQSRSTGPGGTNRSTSWRAEPILNVAKLARLPKDRALVRLPGHEPVLIEKQFWWDNPTLEPLVTRSLARYTNPPIPATPPPRPDNPGGAAGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU96</accession>
    <name>A0A231GU96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776354.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40186">
        <property type="protein sequence ID" value="OXR40186"/>
        <property type="gene ID" value="B7C42_07700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="30279" checksum="2A3DF3110B317F2F" modified="2017-10-25" version="1">MADLALTADRREELAGLLGDEQRLRSEYPKVAEYLDTAPMLPGTGDDRADAAFDLRFVHYMTGGPSISANPYWDIVGPSVSEHEGRRVVNGGRPQGSARLGFAQTILQATYAYAIPSPETITWVREFCDGRPIAELGAGRGYWAAQLTDAGLNVAAYDSEPPDRTENPSFVPAPGQADVWLSVGDLGEFAARGVGRADEVLFLCWPPGWGNAMASDALAAFEANGGRRLVYIGEPKGGKTGNDAFFDALNSRWELESEDSEFVSWWNLSDRAQGWVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV18</accession>
    <name>A0A231GV18_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40473">
        <property type="protein sequence ID" value="OXR40473"/>
        <property type="gene ID" value="B7C42_07411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="21288" checksum="E08E7305781D1FC5" modified="2017-10-25" version="1">MALKEMTDSDYTLPCGRSVEQVWDRLDAVEAGLADEHESECPHCEAARESLLMLRAATRELVDEPDPPPPAMFDRIMSAVRAEVRRGRMVSLTTPHPGSIEVSEQAIAAVLRYAADTVPGVRARSCRIDDHGSDPDGRHAITVALSISLRHGDTTVERVVPQVRERVRAAATARAGLALERLDITVVDVYQEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVF6</accession>
    <name>A0A231GVF6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-methylmercaptopropionyl-CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dmdB_2</name>
        <name evidence="3" type="ORF">B7C42_07302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.44" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909837.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40617">
        <property type="protein sequence ID" value="OXR40617"/>
        <property type="gene ID" value="B7C42_07302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="450"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="545" mass="59224" checksum="C2C3E394679CE9D2" modified="2017-10-25" version="1">MLSTMMDEQLSLATLLRYATTFQRDSTVSTWTGDGVRTMTYRELGLVGARLANALRDLGVRAGTRVGTFMWNNNEHMAAYIAVPAMGAVLHALNIRLFPEQLIYVANHAEDEIVLVDGSLAPMFARYLPYLRTVRHVIVIDDEKPEIAAPPGAVIHRWADLLAAQPDTFEFPEIDERSAAGMCYTSGTTGDPKGVVYSHRSNWLHAMQVISPNGMGFSAADTVLAIVPLFHANAWGIPYAALMSGANVLMPDRFLQAEPLLEMMAAVRPTFAAAVPTIWSGVLARLREQPQNISHLRTVVVGGSAVPESMMRAFQEEYGVSLLQAWGMTETSPLGSVAHPPAGLDDTAEWAYRSTQGRFPAMVRARLVAADGTVVPNDGESLGELEVRGPWVTGAYYSPGGGSVDAEKFDDGWLRTGDIGKISADGFLTLVDRSKDVIKSGGEWISSVDLENAIMGHPAVAEAAVIGVSDETWGERPLVAVVRRPGVSAEPEELRRFLSGSFAKWQLPERWAFIGEVPKTSVGKFDKKRLRAQFAAGELVVIVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVJ9</accession>
    <name>A0A231GVJ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase LipF</fullName>
            <ecNumber evidence="3">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lipF_3</name>
        <name evidence="3" type="ORF">B7C42_07321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40636">
        <property type="protein sequence ID" value="OXR40636"/>
        <property type="gene ID" value="B7C42_07321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="17886" checksum="96CF65EC0655FAB2" modified="2017-10-25" version="1">MAVAGDSAGGYLAIVTALTAIAASRRGDGYPPAALLVLSPVTDATLNLARTRERNRRQKDPFAAAAAVSRVVGLYTAGASAREISVLDADFRGICPIMIHVGGTEMLLGDARALHARVKAAGGVSCLHIWPGQVHVFPALFRYLPQARMALSLSGAFLRNALAVGEAHAATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVP8</accession>
    <name>A0A231GVP8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778713.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40551">
        <property type="protein sequence ID" value="OXR40551"/>
        <property type="gene ID" value="B7C42_07360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="94" mass="10291" checksum="19A55224FD6D222F" modified="2017-10-25" version="1">MQFMVLSRRRTETFTDADFEKVLPAETDHVRKLYLDGVVRQIWLRGDIAGACFTIEAADAEQANAIVAQLPMAAAGVSEFTVIPLSPYRGFGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVQ5</accession>
    <name>A0A231GVQ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40561">
        <property type="protein sequence ID" value="OXR40561"/>
        <property type="gene ID" value="B7C42_07370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="40663" checksum="233B79A71FE2FA61" modified="2017-10-25" version="1">MAEPGAHDEAEWMDYSEFGERFVVHAVNRDRIEAAVSGMAGRGMSIGPFSIGPAGLAGLVAEGKVGKPVIARSEPHVTFEVRVPVSMHLTVTLGGQQFRIEATVEIDLTLHARTADPLLIVIDIPRVRSRDVSFAVRAEAVGAAVDVLLDPIATLVQREVASRLNAMLADPAARRGRVFDIEAIMNGTRSEHVLRTDFEWIEYAEFGRRFFPLIVTPDRVRDVVEGLAGRAVEVGPLRTGPGDAATVEVQGAVRMPRLARREGDHPVSFDLTIPVGLDITVDVLKANRYRAEVEVGLLLVARAAEPLLIVIDVTPPRSADVAVELQAEGWRAKMLGSVGKIRRQIAAQVAQVIRAELADPRGRTIDVAGRIDAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVR5</accession>
    <name>A0A231GVR5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40719">
        <property type="protein sequence ID" value="OXR40719"/>
        <property type="gene ID" value="B7C42_07143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="20874" checksum="3C5A51E9E0D6D701" modified="2017-10-25" version="1">MVEIGNSRTPRRGGAATCLARVLPDLSASRADGSAPGATCKYDHVPVASPASTRNRLFTVGYEGRRADELVAILTEAGVATVVDVRLTPISRKPGLSKTKLSAALGQAGIRYVHLRELGNPRDNRDGFRVGDADARDRYAHVLASPEGAEALHSVRTLMAQGPVALLCFEHDHTTCHRQMVADAVRDTANAGVIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVU7</accession>
    <name>A0A231GVU7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40749">
        <property type="protein sequence ID" value="OXR40749"/>
        <property type="gene ID" value="B7C42_07173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="10920" checksum="9133843A6BDBE11B" modified="2017-10-25" version="1">MGNSVGVNPEQVHATADWLDKSAQDFRDELNSLMKEVRTFVGGEWQGAASGSHSDAWDEWDEGARQIIAGLEHDAAALHQAASLMHSTDQGSAGSIGSTVPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWC8</accession>
    <name>A0A231GWC8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40933">
        <property type="protein sequence ID" value="OXR40933"/>
        <property type="gene ID" value="B7C42_06899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16875" checksum="D532D09918F66D25" modified="2017-10-25" version="1">MRDSVTVHMAASPARVWALVSDVTRIGEFSPETFEAEWVGGATGPAVGAKFRGHVRRNQLGPVYWTTCRVEVCDPDREFAFTVLGPGGMSINRWGYRLEPRDGGTDVTESFELAAIAPLRLYWAALGWARGRRNHKDMATTLNRMKIAVEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWG9</accession>
    <name>A0A231GWG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyphosphate glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppgK</name>
        <name evidence="1" type="ORF">B7C42_06935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.63" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779399.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40969">
        <property type="protein sequence ID" value="OXR40969"/>
        <property type="gene ID" value="B7C42_06935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047330">
        <property type="term" value="F:polyphosphate-glucose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="26243" checksum="91E78100F9DA12B0" modified="2017-10-25" version="1">MSARGQSFGIDIGGSGVKGAVVDLATGDLAHERIKISTPHPATPNAIAETVAKLVTQADWDGPVGLTLPSVVVNGIARTAANIDKSWIDTDARQLFSLALGGREVVVLNDADAAGLAEDRYGAARNIDGLVMLLTFGTGIGSALLNHGVLVPNTELGHIEVHGKEAEHRAASSVKERKNLSYKEWAAEVTKVLVTLEDLFWPTVFVAGGGISRDAEHWIPLLANRTPVAAAHLRNTAGIVGAAMAVDSGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWI9</accession>
    <name>A0A231GWI9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40861">
        <property type="protein sequence ID" value="OXR40861"/>
        <property type="gene ID" value="B7C42_06996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="7668" checksum="35142A8FBE4D7F93" modified="2017-10-25" version="1">MVFGFHVGSPSRRDGTGPARIRLHPGDYRAPLHQTLGSDSLDLAQARVRMLRAEIESARPLAITTDIVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWM9</accession>
    <name>A0A231GWM9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41009">
        <property type="protein sequence ID" value="OXR41009"/>
        <property type="gene ID" value="B7C42_06975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="22838" checksum="73A7FCFDC3C14761" modified="2017-10-25" version="1">MARAGTPIWIRIPRIAVGVLGIVALLWIPLRAHGSPGFSLGNYLGYFTIQSNIAGVLVLLGGGLLDPAARRWQVVRGAATLYLLITAVIYAVLLANIDVMLTDKWINDTLHRVLPIVMVADWILVSARLRVSAALIGGWLIYPLVYCGYSLIRGEIVDWYPYPFLDPRVQGYPSLLIGVVMLAAVITLLAIAVAWLGSLHHRRDAPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWY9</accession>
    <name>A0A231GWY9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41143">
        <property type="protein sequence ID" value="OXR41143"/>
        <property type="gene ID" value="B7C42_06739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="31890" checksum="629C27EA3A7B958C" modified="2017-10-25" version="1">MRALVFSMWASVVFVVVSLTWGLAAGSQMIVFDGLYSLVGIALSAVSVAAQRTVAKGADASYPWGRETWEPVAIVVRSTALGGLCVYGSVNAVREILHGGRAVSAVSALAYAITASLLSVLVALVLWHAGRSGSGLVRAEAAEWGGDAAFSLITLAGFGAAVALEAAGRDDIARYVDPALVIIVSVAYLWIPIRLFRSAFREILTMAAPHSVVTDVERLCDRVRADHDFAASFVRASTVGSRLDLELAFVVGPRTTERTVESFDAVRADIDAQLNARNYHHSTSVVFTANRHWVEWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX04</accession>
    <name>A0A231GX04_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trxB_4</name>
        <name evidence="3" type="ORF">B7C42_06878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41108">
        <property type="protein sequence ID" value="OXR41108"/>
        <property type="gene ID" value="B7C42_06878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="575" mass="61752" checksum="B934612CB10FC0DC" modified="2017-10-25" version="1">MSTRTSSEDPAPVRDIPPVGAETPDELGAYPRLTDDQVATLEVGGTRRSVRAGEVLVREGEPSNDFFVILSGKVAIIDEGDGDGERRILRVHGPGRFLGELGLLEGQVAFFSAEMIEDGEILVVPAERVRELVSHDPVLSDLILRAYLVRRHLLIGLGSGFRIIGSCYSPDTLRLREFAMRNRLPHRWIDLERDERAEQLLRSLGVAPEDTPVVIWHGEKVLRNPTNAELARIVGLPVPDSARDAAQHVCDLVVVGAGPAGLAASVYGASDGLNTVTLESFAAGGQASTSSRIENYLGFPAGISGAELAERAVIQAGKFGARILVSAEVAGLGSEDGLHVLRLADGGTVRGRAVVLATGARYRKLSVPGIEVLEGTSVYYAATHQEARMCGTDPVAIVGGGNSAGQATVFLADRVSHVDLLIRGGDLGKSMSRYLVDQIERHPRVTVHRNTEIREVHGEKYLDEIVVENNHTGAHDTLRVRALFVFIGAVPHTGWLADTVALDDHGFVLTGMDAIRARADGNQWIGDRPSRTLETSLPGLFAAGDVRSDSVKRVASAVGEGAMAVRQIHEYFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXI8</accession>
    <name>A0A231GXI8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="6">DHNA-CoA synthase</shortName>
            <ecNumber evidence="6">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">menB_5</name>
        <name evidence="6" type="synonym">menB</name>
        <name evidence="7" type="ORF">B7C42_06717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="function">
        <text evidence="2">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063016592.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41319">
        <property type="protein sequence ID" value="OXR41319"/>
        <property type="gene ID" value="B7C42_06717"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="28736" checksum="F0DE2C83CC02ECF2" modified="2017-10-25" version="1">MAEFTDITYEVDNGLAWITINRPERYNAFRAQTVDELVMAFKRAWASSDVGVIALTGAGDKAFCAGGDQKQRMETGDYGPSASGLFEVEALHRVIRDAPKPVIAAVNGLAIGGGHVLHVLCDLTIAADTAQFGQNGPRVGSFDAGLGSGYLARVVGEKRAREIWFMLRRLSAQEALDWGLVNKVVPAADLKAEVRAWADQMLDFSPTALKVLKQSMNTDTEHFVSIGTMAYSTLAMFGETPEAQEGINAFNEKRKPDFTPYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXJ8</accession>
    <name>A0A231GXJ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Capsular glucan synthase</fullName>
            <ecNumber evidence="5">2.4.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgA</name>
        <name evidence="5" type="ORF">B7C42_06483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41340">
        <property type="protein sequence ID" value="OXR41340"/>
        <property type="gene ID" value="B7C42_06483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="212"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="43587" checksum="BFE7364828B3E35E" modified="2017-10-25" version="1">MSFADGDREPISLADPDRLRVAMLTREYPPEVYGGAGVHVTELVPQLRRLCDVTVHCMGADRADAVVHQPDPMLYAANSALQMMSAQLRMADAVGAVDVVHSHTWYTGLGGHLAASLYGIPHVLTAHSLEPRRPWKAEQLGGGYRLSSWSERTAMENADAVIAVSEGMRRDVLDAYPTVDPARVHVVHNGIDTRAWFPGGPVPEARDVLAELGVRDDAPIAAFVGRITRQKGVAHLLAAARDIDPGIQLVLCAGAPDTPQLEAEAAAAVRELAATRGGVFWVRDMLPTEQVRQILSAASVFICPSVYEPLGIVNLEAMACGTAVVASDVGGIPEVVADGQTGRLAHYDPQAPRDFERDLADLVNDLAGDAETAARFGVAGRARATAEFSWAKVAARTTDLYDRIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXQ3</accession>
    <name>A0A231GXQ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-methionine-sulfoxide reductase catalytic subunit MsrP</fullName>
            <ecNumber evidence="4">1.8.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrP_2</name>
        <name evidence="4" type="ORF">B7C42_06522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41379">
        <property type="protein sequence ID" value="OXR41379"/>
        <property type="gene ID" value="B7C42_06522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="366"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="637" mass="65784" checksum="435925AC446629F9" modified="2017-10-25" version="1">MAGRDTEIRSTLAIMAGSGLRAACGIVSAGLALGVAELVSVPVGAGSAPLAAIGATVVDHTPDRVREWAIDTFGTDDKMMLYLLMGVVALIVAALVGVIERTARPIGSVLLGVFGIGAAWAALERPAANWTWALPSVVGVALAIVALRWLIRRYEAVAAPIRSGAVPGPSKTTAAQDVRAGSAGIRIEGSPVGAGAGGGRGAGGGAGADVEAGADDPAARGAGAGRGGDADAGRGARADAEADAEDPAAGVGRERTPARSLEDDAPRSARGAAWPRVVKPDVAQVDRRHVMRGIAGVGVLAVAAGIAGRVLGASARSVAGERAAVRLPPPNVPVPPVDPAADLRIPGLAPYLTSNSDFYRIDTALTVPQVSKETWSLRIHGMVDREILLDYADLARRPSVERLVTLTCVSNPVGGDLIGNASWLGYRLDELIAEAGPHPDADMVLSRSADGFTAGSPLAALTDGRDALLAVGMNGEPLPVDHGYPARLVVPGLYGYVSATKWVTELEITRFDRAQAYWTRRGWSERGPIKTGTRIDTPRGAVRAGMVTIAGVAWAQHRGIDAVEVQIDNGPWQPARLAAEPSVDTWRQWSYDWDAPAGTHTVRARATDGTGTVQTAEVADVIPDGASGYPSRTIRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY86</accession>
    <name>A0A231GY86_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41532">
        <property type="protein sequence ID" value="OXR41532"/>
        <property type="gene ID" value="B7C42_06424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="9051" checksum="4F9AEE342DD86F60" modified="2017-10-25" version="1">MDDLQRRVLTALTSARRGLKTADARLLERRIVGLRAEVDAAGYPRPQHLRLKASCAEALAAARWTLGRPNPQAFRPAMQTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYE8</accession>
    <name>A0A231GYE8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6A reductase</fullName>
            <ecNumber evidence="4">1.3.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobK</name>
        <name evidence="4" type="ORF">B7C42_06261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.54" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41620">
        <property type="protein sequence ID" value="OXR41620"/>
        <property type="gene ID" value="B7C42_06261"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="22063" checksum="F9085798FA7AE6B6" modified="2017-10-25" version="1">MREPVLPAGAVRIGGFGGAEGLRKWLADNAIDAIVDATHPFAGTISAHAAAAARAAGVPIVHLRRPGWSEQPGDRWSRVPDLAAAARAVAAFDRVFLTVGRQGVAAFAELGEPWFLIRAIDPPTGPVPPQHLLFLARGPFTVAQEVDLLREHRIAAMVTKDSGGELTAAKLTAARTCGIPVVVVDRPPVPEGVECVESVAAAWEWLNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYN4</accession>
    <name>A0A231GYN4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41708">
        <property type="protein sequence ID" value="OXR41708"/>
        <property type="gene ID" value="B7C42_06050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="551" mass="58764" checksum="45BFF582E9DA25E0" modified="2017-10-25" version="1">MALVADPRIVGEDDGGVFAQVGDESGALGAGDRTAGQVEGILDPGHTAWRCAEGRGALASSGGGPRSGGDFSGAGTIDHLDAVIVEGPPVLVFDPYGLQGGPDRRVDADCEVPLDLWWNAIHPVIAIRIGDAELLACLCLEPALALPLPLEGVILRLVPDSASVCGDVDFALQTTATRRFGMDGSTQRVDFPELFGQCDLAFGSAELGEVAAHDLLQHAGGDRDPAGEPSVDGDGQLFDLGESGEETRRPACRVAVHHIRNPRQYSRSAGCKFLEFGSYAAQPILEFASPLLGQRHVIAPVDVGQQLCQVAFAPLGPSAGLVEPLGRDIRSDIRDQCVGLLCPDKRIGGQLGQHARDIFREAEVCRRVVLVQLVIAVYRRGGRLHVFAEYIENGKVCLFGHRGIGIGVREVGECRRQGGRQSTGVTSEVLGCGTGIRGRRQPSARGCENFERPKKPEVIEPLDGLCYGFTTSRILRSTVPGVFPVLLLVAAHDGLFDLRGGCRIDATLIDTGQCVSEFMRSGAHGPDARCVPRRCAESERPFYGLASFRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYN8</accession>
    <name>A0A231GYN8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41695">
        <property type="protein sequence ID" value="OXR41695"/>
        <property type="gene ID" value="B7C42_06336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="35453" checksum="4DAFE377F199F3EA" modified="2017-10-25" version="1">MSDPSAELTTIDGTPTLRFERRFAHPRERVWRAISDPRQMTAWFPAAVHTELRPGAPMRFVFDDEAPIEDTWDGEVLEVDPPKVFMFRWNRDVLRFELIADGDGCRLVFTHALGDGPTGRLGAARTAAGWDGCLTSLTAALDETEVSQDPATGWLARAEAYIEKFGLARGSAESGTEPESDVVLRFSRDLVWRPADTIWAILVEDQSPRVGAMPPVRATNPQIAPGPVTACDPPRLLEYEVSVDGQPAGRARWEIVADPRLGTRVDFTHTLPHRLASHRAGLLAAWQVQFELFFAATQGEIRCPWPQQRVTELIATYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYT5</accession>
    <name>A0A231GYT5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="3">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fabH_6</name>
        <name evidence="3" type="ORF">B7C42_06126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41784">
        <property type="protein sequence ID" value="OXR41784"/>
        <property type="gene ID" value="B7C42_06126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="111"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="212"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="31973" checksum="04D15D977A840368" modified="2017-10-25" version="1">MSVYLHGISYAVGAREPIAGLEPLRDDPAMLRDMHGLGLYHYCRTEQTPLQLAAEVVASTLDRIPVDAAEIDLLVYASSSPETGALAGGDFLRFCERFGLTRATPIGVTLAECANFGSALRIAHSLVAAGSARNVLVVTSDACPDPHARILRDALSVLSDGAAACLITSAEPSRIEVLGSNQGTNQLIRVAKMPALAGLTKRGLSRAVADMLDRAGLDRGDVRRIIANNVNEEAVRFMADSAGLDHDLCYLDNIADYAHVHSADNLINLQTYLEDGVAPGEIVMTISHGFGTWGVALLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYZ9</accession>
    <name>A0A231GYZ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal chaperone YciC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yciC_2</name>
        <name evidence="3" type="ORF">B7C42_06093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41751">
        <property type="protein sequence ID" value="OXR41751"/>
        <property type="gene ID" value="B7C42_06093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="267"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="434" mass="47043" checksum="CF8CAE7DF72626EE" modified="2017-10-25" version="1">MLSHPDRRTPVVLLAGFQGPVADGMDHLARLLGSAPGTVVVRHDLSSLSEGVVRRRVHLDGRETASVHELAHGCVSCTLRADLLPLLCRLAARDSVHRIVIALDPVFEAEAVCHAIGTVPVVDLVGRVDGPAARDVRIEAVVTGLDARSWLPDALSDETIDERAGGPGDDDRTVAQLAVGQVEFADALVVFGTDQVGDGEREVLRSVVDRLVPRAPSIWAGDGRDIAAARIEMLLDRIPADSRRGRIFDAHAPLLRGRPPLAEENGVALIEFATDRPFHPTRLHEAMDVLFDGVVTARGRIWLATQPERVVWLESAGGGVRVGDAGTWLAAMSPAERESADPDRRALAALRWDEDFGDRDISLVILTCGANPDDIRTALHWALLDEAEMILLRNAPDLVAHWDDPFGEFHEDPCETTESDNSGGRGVESRPNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ70</accession>
    <name>A0A231GZ70_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tropinesterase</fullName>
            <ecNumber evidence="2">3.1.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41916">
        <property type="protein sequence ID" value="OXR41916"/>
        <property type="gene ID" value="B7C42_05900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050357">
        <property type="term" value="F:tropinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="48"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="32538" checksum="270B70F8F3C3D274" modified="2017-10-25" version="1">MVVTAEADVAAPEWFTQAIAELPEHREVDVAGGVVHLRCWGREGTAGVVLVHGGSAHSGWWDHIAPLLAGTHRVVALDLSGHGDSAVRSRYPIEGWADEVMAAAEAGGIAGRAYVIGHSMGGRVSAVAAARHPESMAGLVVIDSPFQEPSEESIVRQLLRRPKTYPTRDEICGRFRTVPDQAVLLPYVARHVAEESVRDIGAGWGWKFDPEMLRKRLEDGRIPPLGSLRAVDASVLYIRCERGLVTRERALEIASLFGRPATVVELAEAGHHPMMDQPLALVATLRTVLAQWDSRDRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZB0</accession>
    <name>A0A231GZB0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41956">
        <property type="protein sequence ID" value="OXR41956"/>
        <property type="gene ID" value="B7C42_05940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="162"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="34644" checksum="953FB12D82BA7F03" modified="2017-10-25" version="1">MTIRTTHTRVVEAPADEVYGLVADVGRWPVIFEPSVLVRHLHRGADEERFRLWATVNGQVTDWTSRRTLDPAGRRITFEQERSRAPIASMGGQWRFDETGPRTTTVTLDHHFTVADGVDPEVITGAVDRNSVTELAALARIAELGYPVDDVIVTFEDRVTLDATAAELYDFVYHSDRWPDHVPHVGRVDLTEDADGVQLMEMDTVTEGGIPHTTRSIRICVPAERIDYKQQLPPAMLFGHSGAWEFADDPAGVVVTARHTVAINPAAARDILGPGTGLAEARAYLGDALGANSRNTLLCAAQYIAARRAESAKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZB2</accession>
    <name>A0A231GZB2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779009.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41947">
        <property type="protein sequence ID" value="OXR41947"/>
        <property type="gene ID" value="B7C42_05931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15852" checksum="EF07CE5611175E75" modified="2017-10-25" version="1">MTTVASRAELYAEVQQFYADQMQRLDNRDITGYAETFTEDAEFEHTPGRPPARTRAGIVSDLVEFHKRFDSDPMQRRHWFNMINLSPRDDGSIGATMYCLVVKIRPGAAPEIAPSCVVHDVLVRVDGELRTQSRRVTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZU0</accession>
    <name>A0A231GZU0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycocerosic acid synthase</fullName>
            <ecNumber evidence="2">2.3.1.111</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mas_2</name>
        <name evidence="2" type="ORF">B7C42_05714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.111" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42115">
        <property type="protein sequence ID" value="OXR42115"/>
        <property type="gene ID" value="B7C42_05714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050111">
        <property type="term" value="F:mycocerosate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="17"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="331" mass="34101" checksum="234B77446B77CA31" modified="2017-10-25" version="1">MAGIPDTMYAAYVEALGPADAIHYGRLPVPRIGPTDVLVAVHAVTVDPVDTFVRSGAYATPTPFPFVIGRDLAGNVAAVGDGAVGYAVGDAVWCNSLGHGGRQGSFAQYAVVPVDRLYHLPDGVDPVQAVGVAHPAATAWLGLFRHARLGLGDVVYIGGGAGNVGDAAVRLARAAGARVIASASGTGLERVRDAGAAVVVDYRDPGMVEQIRAAAPEGLDVYWDTSGHHDIDVAVALLARGGRLLLTAAGPQARVPLPVDRAYTRDITVAGFAISNATVTDLAAAATVLNRKLADRTLTARIADTMPLARAAEAHDRLEKGGVHGRLIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZZ3</accession>
    <name>A0A231GZZ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kmo</name>
        <name evidence="2" type="ORF">B7C42_05731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42132">
        <property type="protein sequence ID" value="OXR42132"/>
        <property type="gene ID" value="B7C42_05731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="37082" checksum="6E17CD65A89F6D3C" modified="2017-10-25" version="1">MVSVIGGGIAGSCLAGGLARRGQRVAVYEQQRPGPGAGAFLFIDGRGHDAMEAMGVDRSALHEVSYPLAGLDYEDSRGRRSAMPSRGHRFWLRRNLMGVLSEFVAGSGAELRYGEPITGVTVSDEHHAIRRGSEVVTAEGLLIGADGIDSVVRAALEPARISVYAGDVVLYGMTGTPLDPPPPTNPAVLHFFAEVAEDGSPGSTFGHIWRPEDPAALWFVRISRDPLPGTRDDVGMRPVDEWAETVLAATPSSRSLVSAFLSRTELVHVSNARNVPLEGARGPQDSVVLIGDADHAITPAAGVGARDALEDARAVFDAILGTASPAEAMTQRRKQIVTDREAALRARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H023</accession>
    <name>A0A231H023_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42217">
        <property type="protein sequence ID" value="OXR42217"/>
        <property type="gene ID" value="B7C42_05816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046134">
        <property type="entry name" value="DUF6131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19626">
        <property type="entry name" value="DUF6131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5585" checksum="860F4EB3D0FC22BD" modified="2017-10-25" version="1">MIILGIILLVVGFLLKIHIIWIIGIVVLVIGLVLLAMGSMGRAVGGRRHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H046</accession>
    <name>A0A231H046_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.127</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhpA_2</name>
        <name evidence="2" type="ORF">B7C42_05791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.127" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42192">
        <property type="protein sequence ID" value="OXR42192"/>
        <property type="gene ID" value="B7C42_05791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="515" mass="57173" checksum="94129920D2986993" modified="2017-10-25" version="1">MSQDFDADVAIIGYGPSGVIAALTLARQGASVVAFERDRDIYPRARAVTINDWTMRIFQSLGIDERIDKVIDPQRMLRWVTYSGEEVMRIEHPPSTLGPGPRFYNIYQPTMEAELRSAGAEYGDRLSVRYGTEVTGIEQDETGVTVTTTDPETGQIRTCRARYAIGADGGSSRTRGWIGANLDCDTADTLWIVVDCAVRRWWPDRDVLTFWTDRKRPVVDIALSGGNHRWELPLMHGETEADFPTAAEVWPLLEAIGVSEDDVDIHRYAFYRHHVRMADTWRNGRIFLVGDAAHLMPPWAGAGMQTGMRDAHNLGWKLGRVLRGALPDSWLDTYEAERRPNATFYTDLAVQLGRVIKQEATQAEVDAMNTVPEGLVTPFEPPLTAPPTLTAGWIRGEVADASIIGRMVPQPIVGDTAGRMTRLDDLLGDGFVLLGDDLDPADLLTPEEKAGWDALGARYVAVRPRTAHTRGRDDLVDLDDVLRPWLQRYGSRAVALRPDRFVAADDVHGLAAPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0A3</accession>
    <name>A0A231H0A3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42279">
        <property type="protein sequence ID" value="OXR42279"/>
        <property type="gene ID" value="B7C42_05478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="28099" checksum="B62EC2E04C8834C5" modified="2017-10-25" version="1">MFRPPYLARVAAGAAVYALEETRRLPTVAIHLPITAISQLLQTSMHLQQFVTSLALKGDEVFDRLANRPVEQPEWATFDEDLDDEQPFGSGDFGARGDRDFAARLSRFDLFAESDPAAGVPEPTASVTPSATNGYAASHTAESDTTEAATAETDTAETTTAGAVETGTNSIETTGEDTDNPGTDNPGTSNPGTAAAEPRGVIEPEVAGRYDYANMTLAQLRARLRMLSVEELAELLAYEQQTLDRAPFVTMLTNRIATVQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H104</accession>
    <name>A0A231H104_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium-protoporphyrin O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bchM</name>
        <name evidence="2" type="ORF">B7C42_05304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42528">
        <property type="protein sequence ID" value="OXR42528"/>
        <property type="gene ID" value="B7C42_05304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046406">
        <property type="term" value="F:magnesium protoporphyrin IX methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="21791" checksum="82BFB2533905D4E5" modified="2017-10-25" version="1">MSGRTPSQWEEITAADPAHSTWYVERFRTMAAQGADIVGEARLIDAMVGRGSRILDAGCGPGRLGGYLYRAGHVVVGVDVDPVLIAAAEQDHPGPTWLVGDLAELDLPSRGIAGDFDVIVCAGNVMTFLAPSTRGAVLSGFARHLASAGRVVVGFGADRGYEFPQFLADAERAGLRVDLRLSTWDLRPFTDESDFLVAVFSRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1A2</accession>
    <name>A0A231H1A2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bglA_2</name>
        <name evidence="2" type="ORF">B7C42_05406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42628">
        <property type="protein sequence ID" value="OXR42628"/>
        <property type="gene ID" value="B7C42_05406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="93" mass="10378" checksum="8B211C2603BA11DC" modified="2017-10-25" version="1">MNVIGYNYWSLTDNYEWGSYAPRYGLYTVDVTTDPDLIRRPTDAVAAYRDITTRHGVPTGYHPPAAGVVLDGRPALQLRRPGERITVPMSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1A6</accession>
    <name>A0A231H1A6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063063336.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42622">
        <property type="protein sequence ID" value="OXR42622"/>
        <property type="gene ID" value="B7C42_05400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="177" mass="18746" checksum="40C6B208ADC8708E" modified="2017-10-25" version="1">MALRRTVHGAWGITMLALVIAACDSGPDEASVAAARSSAYAALTSSSEAAAVSSANRPPLPSAAQLDSQIKRALDPSLPDSERTDLIEDGAAFKDAIPDMYKALHDNPRAVYGVVDPVFDNHDGTLTATMRLDKDGSGENVRTTIVHFVDIDGKWKISRTDLCGILRSADYRTAACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1T8</accession>
    <name>A0A231H1T8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
            <ecNumber evidence="1">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbpA_7</name>
        <name evidence="1" type="ORF">B7C42_05140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42802">
        <property type="protein sequence ID" value="OXR42802"/>
        <property type="gene ID" value="B7C42_05140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="348" mass="36772" checksum="10F18982CCFCAA07" modified="2017-10-25" version="1">MVSSGKRTGAVRGIAWLMAYLGATALLWTSVAPIGSAAPAAHIVGETPGPGRVLEISVHSPAMDRDIPLHVLPAKDSRTPAPTLYLLNGAGGGEDAATWLAQTDAADFFADKHVNVVIPMEGAFSYYTDWERDDPGLAKKLKNNGRNKWATFLTDELPPVIDSAFGATGANALAGISMAGTSVLDLAIEAPALYRSVSAYSGCAMTSDPLGQSFVSLVISLGKGDATNMWGPVGGEGWKAHDPYLHADRLPRIPMYISSASGLPGRHDSLADPSVRANTEVLANQVLLGGGIESAANYCTTKLAERTRELGRTDITYNFHPAGTHSWGYWQDDLHKSWPMMAAAIGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1W0</accession>
    <name>A0A231H1W0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative L-lactate dehydrogenase operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lldR_2</name>
        <name evidence="5" type="ORF">B7C42_05164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42826">
        <property type="protein sequence ID" value="OXR42826"/>
        <property type="gene ID" value="B7C42_05164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="25234" checksum="1A2F3FA6BCA77DD7" modified="2017-10-25" version="1">MAVQPVRRTSLIAQVTEQLRAEIRSGRWPIGSRIPTEPELTELTGTGRNTVREAVQALVHAGMLERRQGSGTYVIAASDLGGTLTKYFADAVERDVLELRQALDVQAARLAALRRDDNDVQTLLRLLERRSQVWDTDSTAAVDADVALHRAIVAASHNTVYLEFYDSLLPVIEDVIRSRTTKYGNQYHDEHAELVHAVIDGDSDRAARAANCFLGSLIAEYPERSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Y7</accession>
    <name>A0A231H1Y7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42859">
        <property type="protein sequence ID" value="OXR42859"/>
        <property type="gene ID" value="B7C42_05197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375768" evidence="2">
        <location>
            <begin position="30"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="38516" checksum="98854884A829FE68" modified="2017-10-25" version="1">MSRFLSVVSVLAPLALAAHAVVAGTVAHADPVPPNPMGPAVPAIADIDADGVPDVVFSDYLLGGGVSVFLGKPGGGLRPAVHYATGGQADYVAITDLDHDGTLDLAVTNFASSDVSILLGHGDGTFAPAVNYATDFAPGALVAADFDHDGNLDLATSNQAPSWSLLRGHGDGTFAPAVTISTAGGVGSGSADVADFDGDGNLDLLRGNYVNSTIQIYRGHGDGTFAAPVTFDSGASTAWYGMARDVTGDGKPDILFSNLVDATVSVLPNRGDGTFSPAVAYPTGGLLPQCFDVADVDGDGKPDLVVANGGTSSIAVLHGHGDGTFDPPAAVYPSGGLVPLSTPALADFNGDGKLDVVIGNTLTGNITLRDGNGDGTFGPAVDYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H210</accession>
    <name>A0A231H210_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42879">
        <property type="protein sequence ID" value="OXR42879"/>
        <property type="gene ID" value="B7C42_05217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="35601" checksum="3D06FE078DED8D03" modified="2017-10-25" version="1">MGYGQWDDSAYAAARTFRAARGLDDFGYTAEMRAKPYPEWVAHPLLDPFGVGVRESRDSAEHGASLPIAVLFDVTGSMGRVPRIMQEKLATLHGLLQRKGYAEDPQILFGGIGDADCDRVPLQIGQFESDNRMDEQLRLILLEGGGGGQKSESYELAAYFMARHTATDAWGKRGRKGYLFIVGDELNKPRLAAGHVRRVIGDDVPQDISVPSIYRELADRWHVYYILPNQSHYYTDPEILEHWRGVLGERVLRLDDPAAVCELIALTIGIGEDRVDLGAGLADLRDIGSGGAADVVGKALAPIGTPAGRRSAGALPAATPGHDDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H239</accession>
    <name>A0A231H239_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative dipeptidase PepE</fullName>
            <ecNumber evidence="6">3.4.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pepE</name>
        <name evidence="6" type="ORF">B7C42_04799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42913">
        <property type="protein sequence ID" value="OXR42913"/>
        <property type="gene ID" value="B7C42_04799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="157"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="375" mass="39421" checksum="2037AD2A1A76D43B" modified="2017-10-25" version="1">MSAHTESRFGAEIYGKRLERAAELTRAAHLDALLITPGPDLRYLLGSAAQSFERLTCLVVPASGETPSVVVPKLELAALDGSAAGELGLHMVSWVDGVDPYGVVKSTLNAGARVAVDDAMPALHLLPIADALTALPVSATPIIRELRMIKDAAEIDALRRAGAAIDRVHARMGEWLQPGRTEAEVAADITAAIEAEGHDRADFVIVGSGPNGANPHHSHSDRIIEAGDVVVIDIGGPVEPGYFSDSTRTYVLGEPDPEIAERYAALERAQAAAVAAVRPGVTAESVDAAARNLLSEAGFGEAFIHRTGHGIGLSVHEEPYIVAGNETVLRPGMAFSIEPGIYFGGEWGARIEDIVVVTEDGGESVNQRPHGLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2M5</accession>
    <name>A0A231H2M5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_21</name>
        <name evidence="9" type="ORF">B7C42_04980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43094">
        <property type="protein sequence ID" value="OXR43094"/>
        <property type="gene ID" value="B7C42_04980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="PTHR10909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="163"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="307"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ACOX" evidence="7">
        <location>
            <begin position="525"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="673" mass="73605" checksum="7B38B14DEFBD7813" modified="2017-10-25" version="1">MGTDTATGTEAADSVRSNSAQPEAGTSNTGPSKTGKSTADHLRAALDGPWREVREQARRQLADDRLFGDPYLDYRQARARVLEQMRLIAEFGYAEKGFSLEHGGTGDPGGAVTGLEMLAYTDLSLWVKAGVQWGLFGGAVENLGTDRHTDVVKRLLSLDLLGCFAMTESGHGSDVANLETTATYDPATGEFVVHSPTASARKDYIGGAAEHARMAAVFAQLITGGESKGVHCFLVPIRDEEGNDLPGVTTSDCGLKGGLPGVDNGRIEFDHVRIPRENLLNRYADVDADGTYHSDIENPSRRFFTTLGTLVRGRISVGGAAAAGARVALSIALRYGDKRRQFSDPDDGSETLLLDYRSHQRRLFPHVARAFALSFAQNDLVRRMHLIQTGQNLDPEAQRALEKRAAGLKVAQTRHATRAIQECRECCGGAGYLTENRLVTLKADTDVFTTFEGDNVVLTQLVAKELLTAYSDEVRDLDALGWVKFAATMARDVVRETSGVRQLIQRLRDRSDDGVDEGDLSRRSVQLQLFADREDYLTRTAAHRLRARAEETGPFEAFNNAQDHILAAGEAHIDRLVLEAFIEGIADIEDPDARALADTVCDLFVYSTIEQNQAWYIMHRFMSVDRAKSVRRGVNELVDRLRPESATLVEALGVPEAMLRAAMLDDASVHQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2R7</accession>
    <name>A0A231H2R7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor AcnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acnR_2</name>
        <name evidence="5" type="ORF">B7C42_04572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009800.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43150">
        <property type="protein sequence ID" value="OXR43150"/>
        <property type="gene ID" value="B7C42_04572"/>
    </dbReference>
    <dbReference type="GeneID" id="66723543"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="23484" checksum="AD22B57768EBC6B2" modified="2017-10-25" version="1">MAATRAESYLQQQERRSRASRQQILDAAVQCLVEYGYAGASTLRIQELAGISRGRLLHHFSSRDELLVGAVQHLASARVAELRTEVGSMIAVPDDDPARIDEAIGQMWTNFHQPFFWASIELWVAARHNDSLREALRPAERQLQKAIHETLAVMFGPVWSARPRYQQVVDTLLSSMRGASVAYGFDPRTPARDPHLAQWRDVARVLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3M6</accession>
    <name>A0A231H3M6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">pdxS</name>
        <name evidence="6" type="ORF">B7C42_04335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_062997834.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43468">
        <property type="protein sequence ID" value="OXR43468"/>
        <property type="gene ID" value="B7C42_04335"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="13"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="31827" checksum="6526611B8209F548" modified="2017-10-25" version="1">MTTPDTTSTTGTARVKRGMAEMLKGGVIMDVVTADQAKIAEDAGAVAVMALERVPADIRAQGGVARMSDPDLIDGIVNAVSIPVMAKARIGHFVEAQILQSLGVDYIDESEVLTPADYANHIDKWQFTVPFVCGATNLGEALRRITEGAAMIRSKGEAGTGDVSNATTHMRKIRGEIRHLQSLPEDELFVAAKELQAPYELVREIAETGKLPVVLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGNPAERAAAIVKATTFYDDPDVLAKVSRGLGEAMVGINVEEIPEPHRLAERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3R0</accession>
    <name>A0A231H3R0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TraG-D_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43508">
        <property type="protein sequence ID" value="OXR43508"/>
        <property type="gene ID" value="B7C42_04375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="3">
        <location>
            <begin position="416"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="610" mass="66094" checksum="4DCD7221F301AC1A" modified="2017-10-25" version="1">MAKKVKDPADPGPDLALYLIYIGFAVVGTLWVALHVGNKLSTVPQDVPINPIACIAKIARGQLEWPTASTVIVLLVVLVVAGIVFVRREMKKRRNRGKLPVDDKAQYMGSGGAIAALTEAGVRDKAQQLGVRLGYDDSPGVPIGVGVVDGVMLFGSYEDLHLDIWGPRQGKTTSRVIPAILSAIGPVLVTSNKRDVVDATRDVREGKGSRAFVFDPQGVAGETHATWYWDPLGWVDARHEGCEMRAARLAGHFADAEDSDGTPDSYFDPEAEDLLAGLFLAAAVANRPITQVWEWVTDPSNTESVQLLRAASHHLVASGLAQQYNTAERVRDSIFGTAKKMVRCLKLSNVHQWVTPGGDRYQFDEWDFLDRNSTLYCLSLEGRGSAGPLVSALTEAVVDVAMRKATHEHLGRLSIPLLAVLDEAANIVRWKDLPKQYSHFGSRGIVVMTVLQSWAQGVRCWGQAGMEALWAAANIKVLGPGIDDMTFLAARSEAIGDYDSISSSVSESKGGKSYSRSLGSSRTLNPNALATLPRGRAVVFSSGAPAVLVRTVPWWEGEYAAEVRKSIEQHDPQRRTTMSDLVGERTVLDGGSMPGEPPVTYGQPEEVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3X0</accession>
    <name>A0A231H3X0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azoB_8</name>
        <name evidence="2" type="ORF">B7C42_04435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43567">
        <property type="protein sequence ID" value="OXR43567"/>
        <property type="gene ID" value="B7C42_04435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="29447" checksum="AE6E814978E468BA" modified="2017-10-25" version="1">MIVVTGATGNVGRPLVRMLAEAGEKVTAVSRRRPDDLPHGVRHLAADLTNTGEVTAALDGAEQLFLLLAPGSLAADVPGVLAAAREAGVRRVVLLSSQGVGTRPDSPSHGQFGKQVEVAVQNSGLEWTILRPSGFQSNVAMWADAVRTQRTVTAPFGDVAIPFVDPDDIAAVAAVALREPGHAGRTYVLTGPAPESPRDRVRDLAETLGEPVRFVEQTAEQAYAQLLTVMPADAADTTLAIIGAPTAEELRVSGDVEAVLGRAPRPFSAWARRNIDMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3X3</accession>
    <name>A0A231H3X3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pyrF</name>
        <name evidence="9" type="ORF">B7C42_04428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43560">
        <property type="protein sequence ID" value="OXR43560"/>
        <property type="gene ID" value="B7C42_04428"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="28011" checksum="52B0D582084A92A8" modified="2017-10-25" version="1">MTPFGPRLADAMGRLGPLCAGIDPHPQLLRAWGLGEDVEGLKRFSDICVEVFAGRVALVKPQVAFFEEYGSGGIVVLEDTIAALREAGTLVLADAKRGDIGSTMAAYARAWLGDGPLASDAVTVSPYLGFGALSPALEAARSAGRGVFVLAATSNPEAAQVQRVTAADGRSVAQIMIDEAAGCNAGEEFGSVGVVVGATLTEPVDVSKLNGPVLMPGVGAQGGGAESIRALIPSDRLAAVVPNVSRELLGAGPSVAAMRTKMHKLADEFAFLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H449</accession>
    <name>A0A231H449_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="11" type="ORF">B7C42_04353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43486">
        <property type="protein sequence ID" value="OXR43486"/>
        <property type="gene ID" value="B7C42_04353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="608" mass="62930" checksum="D603A31C0310AA19" modified="2017-10-25" version="1">MPPSKGTGHPLRLLGVYAVLLAVIYALVFFTGDKSPEPKLGIDLQGGTQVTLTPRTPDGGKPSKDSLKQAQQIIESRVNGLGVAGSEVVIDGNNLVITVPGNDGQQAKSLATTAKLYIRPVVGQPLPVGPDGKIQSGGETAPGAEQPGTPPANTPEPAPGAGQQAPTPGASSGTEPKPSNESGTASGTASSGETSGTGESSGTTAQNRVFPAPAQAPTTPAPTPTPAPGSGAPNPALTPQQQAKQEIDAARALRQSTDPQVQQLAAQQLDCHKPDPLAGNDDPKLPLVTCSSDGHEVYLLAPMRIDGQDIKDASSSLNQQSQWAVDLTFKNADAWADLTKEYLQKQVAFTLDSKVISAPVVQQGPQLGGTTQITGQFNASTAKELANSLKYGSLPLSFEVSEASTVSATLGLASLHAGLIAGAIGLVAVLLYCLLYYRMLGFLAGFSLVASGVAVYGIIVLLGRWINFTLDLAGIAGLIIGIGMTADSFVVFFERIKDEMREGRSFRSAVPRGWARAQRTNLSGKTVSLIASVVLYILAAGQVKGFAFTLGLTTVLDVVVLYLVTSPLMMLASRSPFWAKPSVNGLGAVQQLARERKAAGTLVGTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4J1</accession>
    <name>A0A231H4J1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43784">
        <property type="protein sequence ID" value="OXR43784"/>
        <property type="gene ID" value="B7C42_04019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="345" mass="36778" checksum="2204EE0527D0EFD0" modified="2017-10-25" version="1">MPERSKDARTGFIAGRFGEFPARWGQGLSDQLTRIARSPFGPSEEEVRANLAGEASADAALALHDAELAETYGAESDSELPPHARPPRDLTAAAFFDVDNTMVQGASIVHFARGLAARKYFKTSDLVDMAWKQVKFRVTGKESQGDMASGKEKALSFIAGRSTAELAALGEEIYDEIIADKIWPGTRALAQMHLDAGQQVWLVTATPVELAQVIAKRLGLTGALGTVAESVDGVFTGRLVGDILHGLGKAHAVRTLAIREGLNLKRCTAYSDSHNDVPMLSLAGTAVAINPDSDLREVAKNRGWEIRDFRTGRKAAKIGVPTALALGAAGGAAAAVLTRRREQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4X3</accession>
    <name>A0A231H4X3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_12</name>
        <name evidence="2" type="ORF">B7C42_04107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051025192.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43868">
        <property type="protein sequence ID" value="OXR43868"/>
        <property type="gene ID" value="B7C42_04107"/>
    </dbReference>
    <dbReference type="GeneID" id="66724226"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="30549" checksum="33DC9AF93B524E01" modified="2017-10-25" version="1">MVVSQRSPIFSRRMRRVGAALKSPVNVIDRAGDQMSFYSKAIAWIPRTVVHYRKEVMRLLAEVTFGSGALAVIGGTIGVVVMMSASVGVVVGLQGFKALDALGSSVLTGFLTGYINTRELAPLVAALALSATVGCGFTAQLGAMRISEEIDALEVMAVPGVPFLVTTRVIAGFVAVIPLYIVGLLGTFIASRQISVWFNGQSTGSYDHYFGLFLPPEDVLYSFVKVLVFAFVIILIHCYYGFNATGGPAGVGVAVGRAVRASIVLVNILDFFLSLAIWGTTTTVRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Z5</accession>
    <name>A0A231H4Z5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulatory protein EmbR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">embR_4</name>
        <name evidence="4" type="ORF">B7C42_04180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43941">
        <property type="protein sequence ID" value="OXR43941"/>
        <property type="gene ID" value="B7C42_04180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1114" mass="120190" checksum="7F7D10EF7342523C" modified="2017-10-25" version="1">MAERRIHVLGPMHIALDGTPIRLAGRLTRALLARLVIAQGRAVSTDRLVDELWDGEPPPKATSVLQVHVHNLRRVFEPERPARAPATVVVSEGLGYALRLRDTEVDAWQFESLLHEYLQVSSGAHAPEAATRTRMLDIALGCWNGRALESFADCGWAAAEAARLTDLYLTAGELRAQAALELGRTTEVISGLRRTVEDRPDREESVRLLALAQYRLGQQTEALATLRRTAEFLTREMGLDPGQRIQELETAILNQAVPVLDSTVATAPIAVRADIVRDTTRSPTEPGERAETTTAPGYPVQRKVVLEAACEAAEHGARVVWVCGGAGFGKSTLTETVATELRRRDWVVATGRCPEVDGAPQAWVWAEIAARFGADLTSRPVLGGAFEISRVIADRCRKAVADGPVALILEDLHRADEATLQILRQAMAWLHDQPLLVIATLRETEAPAPVRAAVAALADPTAAHIELTGVDLDGTCAIARAAGLSGLDTDLLALLHERTGGNPLFLRELTAAMAVGGDVHALPPSTRGVIEQQLARMPDPVREVLEYAAVCGERVEPATLVALTGRSEPEIVDLVGTAEVARLVIIDPAGRIMFAHPLIRDTVYAGIAQLRRTRMHQGVLALLGGCRPDDTRAVEVLAHHAVRAATASTADSAVDYITTAARHCVERGMRADAAPLWRTVIELRRLAGHEDDDAPAADRIACVDAYCELVTASAYAGRIVAARDAREQALRLATALGDGELVVRALTSWRAPVVWAMRDWRWTNPRLRRALAVASARDQPVATQARLLITAVFEASPAAHRLAHTRAHAALKLARSTGDAELQCMALNALTHLVLDGHSGDGLGYWTAELERIATAADLPHYRALAHYLHFRTACRNVDLIEAGRQARLALEFAATAQVRPLTTIFGYFRAAIEILRGDISRAAHYFDESISAARDSGFPHGDEAALIALLPLGWARRDLSLAADALADIEAALPGMLTQIYIVALLDAGARAEAAALFHHGPEVDEHFYPVLMRAHRARAAIALGSTADCAELYRRLLPAAGTVAGLETGFTPLDPVDEILADLAAACGDGVTAAKHRAAATRLRERIRKQLRSTQLTNIDTIGPARDFPAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H517</accession>
    <name>A0A231H517_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate racemase</fullName>
            <ecNumber evidence="2">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="7" type="ORF">B7C42_04166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781044.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43927">
        <property type="protein sequence ID" value="OXR43927"/>
        <property type="gene ID" value="B7C42_04166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="26515" checksum="F0FA0D4D90C6519B" modified="2017-10-25" version="1">MIVALIDSGLGLLPTGAWLRKLRPDLDLLLQLDPDGAPWGPKPEQWVIDRVLDAARRSLRLGAEAIVLPCNTASVTALEQVRAEVGPEVPVIGTVPAIKPAAAACASVAVWATAATTASRYQADLIARFGGEADVTGVACHGLADAIDRGDLPAVEHAIARAAEQTPAGTEAIVLGCTHYPLVLESIVAALPPGVRLFDSAEAVAGQTLRRIDALGRPTAGTGTVTVYNSGRAGELPASAAAFESGRVLGAVDTACPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H563</accession>
    <name>A0A231H563_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain reductase protein NovJ</fullName>
            <ecNumber evidence="1">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">novJ_2</name>
        <name evidence="1" type="ORF">B7C42_03639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44083">
        <property type="protein sequence ID" value="OXR44083"/>
        <property type="gene ID" value="B7C42_03639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="26243" checksum="00ED1F308782FB38" modified="2017-10-25" version="1">MTDQRRVAVVTGAARGIGAATAARLAADGAAVAIADLDENACKTTADEIVAAGGVAVPLACDVTDEASVDSAFDRVAAELGSLDILVNNAGVLRDNLLFKMSADDWDTVMSVHLRGAFLCSRAAQRHMVTRRYGKIVNTSSVSALGNRGQANYSAAKMGIQGLTRTLAIELGPYGITVNAVAPGFIVTEMTAATAARVGVTVEEWQAKSAEITPVRRVGRPEDIANTVAFLASDEASFITGQTIYVDGGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5K0</accession>
    <name>A0A231H5K0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="4">2.3.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioF</name>
        <name evidence="4" type="ORF">B7C42_03734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44174">
        <property type="protein sequence ID" value="OXR44174"/>
        <property type="gene ID" value="B7C42_03734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="28"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="39284" checksum="5784BF910CBEE1C7" modified="2017-10-25" version="1">MSWLDERAGDRVRAGLRRQLRARPAHSDLIDLASNDYLGLSRHPEVIAGAVEAVRTWGAGATGSRLVTGTTVAHEDFEADLADFVGAQAGLVFASGYAANLGVVTALAGRGALVVSDAGSHASLVDACRLSRARVEIAPHRDVEAVDRLLSQRTEERALVLTDSVFSADGDLAPLTDLHRVVRANGAVLIVDEAHGIGVRGDGGRGLVQELGLAGQPDLVVTATLSKALAAQGGIVLCDERVRAHLIDTARTFIFDTGLAPAAVGAAHAALRLLRKEPELGGRVLARAADIARIAAVPQPDSAVVSVVLGQAQVAFDAAQQCRARGLSVGCFRPPSVPEGTSRLRLTARADLTDAEMRTIATVLGEVLTTARNSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5K9</accession>
    <name>A0A231H5K9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44115">
        <property type="protein sequence ID" value="OXR44115"/>
        <property type="gene ID" value="B7C42_03672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012149936" evidence="1">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="23465" checksum="0823E7DFC8062CF9" modified="2017-10-25" version="1">MAVVTSLVRLSAALTVTGALTFAGAAAATAAPPDPAATIAALGQNPAAATDLLSAYQTAVDSLKQLGIQPFLYPSGSAFCQDGSTLGLVPALAGAVPGPWPKLAVPVPGLDLSAVKAGQTMFAFVPYGMAPDGPDTTGMQVAWFNVSNGRGGFAAMGPLSQVIGSMVPPNLPPEVRPAFEQAIRNFFLASLPVGGVRAVPVDTGSGTVLAAVFGTVRNGANTCMFLPTVGVTSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H687</accession>
    <name>A0A231H687_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44371">
        <property type="protein sequence ID" value="OXR44371"/>
        <property type="gene ID" value="B7C42_03160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="64" mass="7206" checksum="8BE449E79B4DA0C5" modified="2017-10-25" version="1">MHYPDRMNTLQAAEYLGVSPQTLRNKRARGGGPRSYRILRDVVYDRADLDLFIAQQKAATLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6B5</accession>
    <name>A0A231H6B5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Murein hydrolase activator EnvC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">envC</name>
        <name evidence="2" type="ORF">B7C42_03353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44563">
        <property type="protein sequence ID" value="OXR44563"/>
        <property type="gene ID" value="B7C42_03353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="211"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="34472" checksum="B0084C0E0418A4D3" modified="2017-10-25" version="1">MIRPDWRTTLRRDRPSFTGRMRSSARRSRDLGQAAAVEWRARSRRWRRALRNRDWREEFETLWPRLRGWVGDHRVLVIGMVVVGLFAAADTVAPQPIESTPKPGAAQRIAVAYPLQVQAEPETSKRYLAAIDNGERMREAQVVAAASRATLDRAKAEAAAAVAGTPQPWLSGPATTIPGGIAPDGIAPGIGGFALPARGVFTSGYGGRWGTFHYGIDIAAPIGSPIYAVADGTVIDAGPAQGFGLWVRIRHDDGTISVYGHMYDFSVSVGERVRAGQQIARIGNRGDSTGPHLHFEILIGGQHVDPQPWLAVHGIQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6J5</accession>
    <name>A0A231H6J5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775758.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44459">
        <property type="protein sequence ID" value="OXR44459"/>
        <property type="gene ID" value="B7C42_03248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="14605" checksum="7081936350FCEF77" modified="2017-10-25" version="1">MTSTIQPAAVQAGTTLPELVIHADPTFVVSTALATRDFQDVHHDRDKAVERGSKDIFVNILTDTGLVQRFVTDWAGPGAIVKSVALRLGVPLYAGDTLTLSGTVAAVDGADITIDVVGKDSLGDHITAKAVISLQEARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6L3</accession>
    <name>A0A231H6L3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44356">
        <property type="protein sequence ID" value="OXR44356"/>
        <property type="gene ID" value="B7C42_03144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="107"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="26322" checksum="C52126AD6799383D" modified="2017-10-25" version="1">MRSASVWVVTDVLQPLVELPGVRDAADRARDALAEVHRHKANRRGWPTTAAEAAVRAARSSAAIDGGATELPADGRVADPILAGALRVGQALDGDALRNLVGVWQRAPLQALARLHLLAAADLVDDEIGLGRPRPEPGVAERLDLLAQTVLTSTAPAPVLAAVVHGELMSLRPFGSADGVVARAASRLVAVASGLDPHSLGVPEVFWLRRRQAYVDAAAGFAGGTAEGVGGWVVFCCGALEDGAREARSIADAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6R0</accession>
    <name>A0A231H6R0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhpD_1</name>
        <name evidence="2" type="ORF">B7C42_03259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.80" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44470">
        <property type="protein sequence ID" value="OXR44470"/>
        <property type="gene ID" value="B7C42_03259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008684">
        <property type="term" value="F:2-oxopent-4-enoate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="27973" checksum="33E3543B28E2C537" modified="2017-10-25" version="1">MLSDAVRNELAAELAVAERDRVPIDPLVTRYAAIDVVDAYEIQLINIRQRLADGAKVVGHKVGLSSKAMQEMMGVDEPDYGHLLADMQVFEDIPVDTSKYLFPRVEVEVGFVLGADLPGEECTEADVLAATVAYAPAIELIDTRIKNWNIALCDTIADNASSAGWVLGPERVAPDALDIKAIDATLTRNGEVVAQGRSDAVLDDPTIAVAWLARKVASFGVRLKAGDIVLPGSCTRAIDARPGDDFHAEFAGLGSVRLTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H729</accession>
    <name>A0A231H729_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44557">
        <property type="protein sequence ID" value="OXR44557"/>
        <property type="gene ID" value="B7C42_03347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="7830" checksum="627EBC90068F200E" modified="2017-10-25" version="1">MDTGKVVMGAIRGLLDVVLGILTAVLGTVVALLAVVVWILGAVLCVTILLIPLGIPVFKLGSRLFGLARQLMHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H736</accession>
    <name>A0A231H736_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B7C42_03392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44602">
        <property type="protein sequence ID" value="OXR44602"/>
        <property type="gene ID" value="B7C42_03392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="26"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="379"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="422"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR44602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="596" mass="61712" checksum="87E3AD3C08D1370F" modified="2017-10-25" version="1">MDAVKSLWAELRELRRMSEISPWRVVVSICWGTIALGSGLALAALAAWLIARAWQMPPVLDLSVAVVAVRALGISRGLFRYIERLATHDVALRAMTTARTSAYAALARADFWTLRREGRSEQPQRRPAGPSQGGAIGRPDSGSGAGRGIGLLRRGDLLTRIGADIDDLGAVVVRAVVPIAVAILLSVAAVALLATISVPAGVILAVALLVSGGFAPWLSARAARDAELAVQSDRAEFRAAAVTVLDHAAELRVAGRLDAAMTAATTASARAVRAEDRAAARSAWAAAATPLSVGASVLGALLIGIALYGNSFGAPAEPLQPAPAGGITPMAFAILVLLPLSAFEAVAVLPAAAQAITKGRAALRRIRALDPAELRTRAVATEDVATDDDASAPADYASGDLRARLIRALPDLPPGRRIAVVGPSGAGKTTLLMSWAGLFGTPRPGRTFFAEDAHIFGTSVLENLRVARGDVTDAEAENAVRAVGSGPWLDALPEGVETDLVGGAAALSGGQRRRLLLARALVAPADTLLLDEPTEHMEAAAGAELLRALLDETSGLVDPDRTVVVVTHQLPPDHRADTVVTVAPGGEISITRRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H769</accession>
    <name>A0A231H769_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminomethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gcvT_1</name>
        <name evidence="5" type="ORF">B7C42_03387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44597">
        <property type="protein sequence ID" value="OXR44597"/>
        <property type="gene ID" value="B7C42_03387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="4">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="39409" checksum="ADDEBB7FBAFD09F0" modified="2017-10-25" version="1">MVAAPSPLLGLPGAVPGPPESPDAAVAWHYGDPFGEQRAAAQRVALVDRSHRFVARITGAERLSWLHTISSQHIAELSDGRSAENLDLDLNGRVQHHFVLTELDGTVWIDTEGDRGPALLDFLQKMVFWADAKPEAAADHAVLSLLGPRVSDLTETLGIAALPQVYGAVALPGGGFLRRMPWPTEDSYDLVVPRERLSELWTALTAAGAEPAGLWAFEALRVAALRPRIGVDTDDRTIPHEAHWIGGPDEFGAVHLNKGCYRGQETVARVHNLGKPPRHLVLLHLDGSADARPTAGDAVTAGGRAVGRLGTVIDHFELGPIALALVKRAIPADTRLEAGPMAAAIDPDSIPSDDEPQAGRLAVDKLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7P9</accession>
    <name>A0A231H7P9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="7">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phrA</name>
        <name evidence="7" type="ORF">B7C42_02833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44879">
        <property type="protein sequence ID" value="OXR44879"/>
        <property type="gene ID" value="B7C42_02833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="440" mass="49384" checksum="8C3AE9DC419BD03F" modified="2017-10-25" version="1">MGVAVALFTRDLRVHDNPMLTAAQRAGDAVVPLFVLDESLVTGSAAAPNRVRFLAAALDELDDELRTRGGHLVLRRGAVVDEVERIVAQTQAESVHLAAEVSYYGKRRESALRDRLESRGCQVHTHAATVTSVDLDAIEPSTGRDHFAVFTPYFRRWESARHRRPLPPPKNLEVPRLDGEQPGLDELRTVRTSPNLRVGGETTGRKMLRRWLSDPVTAYDEANDDLAADATSHLSPYLHFGCLSAAEVVSRLDMSDPGAHSFARQLAWRDFHHQVLAARPAAAWSDYRSGPVEIRKDEQAFEAWTHGRTGFPIVDAPMRQLRDQGWMPGRARLITASFLAKTLRLDWRSGAAHFRYWLVDGDVANNQMNWQWVAGTGTDTRPNRTLNPLRQAHRFDPEGEYVRRWLPELAHLSGAAVHRPWREDMDEATYPAPIAEVPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7T2</accession>
    <name>A0A231H7T2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ATP:glutamine synthetase adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">ATase</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl-L-tyrosine phosphorylase</fullName>
                <ecNumber evidence="3">2.7.7.89</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl removase</fullName>
                <shortName evidence="3">AR</shortName>
                <shortName evidence="3">AT-N</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl transferase</fullName>
                <ecNumber evidence="3">2.7.7.42</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl transferase</fullName>
                <shortName evidence="3">AT</shortName>
                <shortName evidence="3">AT-C</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">glnE</name>
        <name evidence="6" type="ORF">B7C42_02730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18589"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP</text>
            <dbReference type="Rhea" id="RHEA:43716"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.7.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GlnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.89" evidence="3"/>
    <dbReference type="EC" id="2.7.7.42" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44776">
        <property type="protein sequence ID" value="OXR44776"/>
        <property type="gene ID" value="B7C42_02730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047388">
        <property type="term" value="F:[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000820">
        <property type="term" value="P:regulation of glutamine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00802">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="107"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="334"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="586"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="848"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl removase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl transferase" evidence="3">
        <location>
            <begin position="493"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="992" mass="108505" checksum="07CCA452C7900B68" modified="2017-10-25" version="1">MPGAGRLGLLEPTAAASLRELAWDNVDSVSLLWALSRSPDADLALLTLIRLREALGSDWAALDSAVRTDLSLRGRLFALIGSSSAFADHLVADPASWQLLRRELPSTREILDDLLDVVGATPETGPNAAPMLYRAAHAGPDAIALLRKRYRDQLMVLAAHDLAATVENEPVLPYQQVGNHLTDLADAALTAALSVAVTRICPDEPVPVRLAVVAMGKCGARELNYVSDVDVVFVAEPADTTATRLAAEMMGIASSAFFDVDAALRPEGKAGALVRTLDSHITYYKRWARTWEFQALLKNRPATGDLELGRQYGEALMPMVWSASERPDFVSDVQAMRRRVESLVPEDLRERELKLGHGSLRDVEFAVQLLQLVHGKADESLHVPGTVEALTALAARGYVGRDDAANLTASYEFLRLLEHRLQLQRLKRTHTLPAPDDEEGMRWLARAAHMRPDGRQDAVGVLRSEIKRNTLRVRRLHAKLFYRPLLESVARLDAAALRLSPQAAVRQLAALGYAAPENALGHLKALTGEVGRKGRIQALLLPTLLEWLGDTPNPDAGLLAYRRVSEGLDDQIWFLRELRDEGAIAQRLMIVLGSSAYLPDLLINAPETIRMFADGPDGPLLLSPKAEDVRSSILAGAARYDEPRRAVATARSLRRHELARIASADVLGMLEVPRVCRALSSVWVAVLEASLQAVIRAWEAEHEAPAPADFAVIGMGRLGGMELGYGSDADVLFVCDPRPGADETVAVKWAIGVAEQVQRLLGAPSTDPPLQVDAGLRPEGRNGALVRTLAAYRAYYQQWAQPWEVQALLRAHQVAGNEELGLRFLHSIDPVRYPKGGVSEEAVREIRRIKARVDSERLPRGANPATHTKLGRGGLADIEWTVQLLQLQHAHEVPDLHNTSTLECLAVIEREKLLDALDVELLRDAWLTATKARNALVLVRGKPADQLPGPGPLLSAVARVAGWPTDDGSEFLDHYMRVTRRAKTVVERVFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Z3</accession>
    <name>A0A231H7Z3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44846">
        <property type="protein sequence ID" value="OXR44846"/>
        <property type="gene ID" value="B7C42_02800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="191" mass="21465" checksum="812D9C4E29B704C8" modified="2017-10-25" version="1">MPYLTSDVITAGMLSRNEQPEVAVGSELRLRPWDANDAELLLSVYADRDIQQWHCRTLTDLDEAREMIDRWQSAWRLETGAHWAITSGRRVVGRAGFRHLDLAYGEGELAYWAVPGQRGHGYVPAAVTALTHWAFDIGFLRVFLRHSSANTASCRVAEKTGFRYEGTLVSAAPHTDGRHDMHVHARTTNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8H2</accession>
    <name>A0A231H8H2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45138">
        <property type="protein sequence ID" value="OXR45138"/>
        <property type="gene ID" value="B7C42_03095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="181" mass="18686" checksum="935CFC590E168CF0" modified="2017-10-25" version="1">MLCVGLSALFYAYCYEESDSCAVGTRGAGRAAAAVAVVDFTAIGLSSWLGVLEFFGHPPMKIAGFPIWWAAIDALDVVLGGLIVYLLISRLRGWSTAWFVLVPSIALGAASGIVGWPISTPLNSEWGMPAKYLCALASIALSLACLHFLSRALPKVAETVGEGAGGPAGRAPVADLDAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8N0</accession>
    <name>A0A231H8N0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid permease YhdG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhdG_1</name>
        <name evidence="6" type="ORF">B7C42_02344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776789.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45219">
        <property type="protein sequence ID" value="OXR45219"/>
        <property type="gene ID" value="B7C42_02344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017794">
        <property type="entry name" value="Urea_CO2ase-assoc_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03428">
        <property type="entry name" value="ureacarb_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="507" mass="53050" checksum="EFEA693B85053DD9" modified="2017-10-25" version="1">MAIALDPPSQSPTGDSADLERFGYQPVLHRKLGRYASFAAGFSFVSILTTIFQFFGFGYGFGGGAFFWTWPIVFAGQFLVALNFAELAARYPISGCIYQWSRRLAGEVVGWFAGWMMIIAQIVTAAAAAIALQVVLPSIWSGFQLIGTDTALTSTDGAANAVLLGSVLLVITTVINVIGIDLMARINSIGVTVEIVGVLAVIALFFTHTERGADVVLQTDQAAPGPYWAAFLVSGLMAAYVMVGFDSAGELSEETKNPRRVAPRTILLALAASALGGGLLLLGALMAAPSITDGHLATDGLAYVITAKLDSPAGTVLLCCVAVAITVCTLAIQTAGSRLIFSMARDGRLPFASKLAAVHPRFGTPILPAVIIGVLAVALLVVNLGNAALFATLASVCIVTLYVAYLLVTVPLLVRRLRGLPPAEPGLFSLGRYGIAVNVAAVVWGIAMAVNLAWPRAEVYTPAGGGWWMLWAAPLFLLLTVTVGAVVHRIVTPRAAAAEARPAPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H922</accession>
    <name>A0A231H922_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase ORF5 in fasciation locus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fas5</name>
        <name evidence="3" type="ORF">B7C42_02474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45349">
        <property type="protein sequence ID" value="OXR45349"/>
        <property type="gene ID" value="B7C42_02474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="45457" checksum="0F65C4B8C30B2E07" modified="2017-10-25" version="1">MSAAEVSAGEFDTDFGGLHRATPRAVHRLPSAFPSALLGSGRPLTLRGSGHSCAGQTVTADELLVTYAPESATREIRDLGEGLFEVPAGASWHGLERYLNRRGRAFPVLPNYLHMSVGGTLSVGGAGSESIRSGWQLDQVERIQLIDGTGSSRWCSRTEHAELFRFALGGLGAVGLIERAVLRTVEYEPRIHEHRADHATLGALAEHTARVARAGDVDSYWGMSRHGRIRSVTGWRGDGPARPCDGENCAVLTESPMWETDPHAAPPPPADRGRMWADYVVPAEHCVAMFEVVAAQLDRAPFDDPSTMVYALVVRRPPDPVPFAFAPVLTAPVSVGVGLYATVDRDPAAKADVRQTFRDLQRRCCELGGRPYLYGVVDLDDAKTAGLYGDDLDRLAELRASLRLGHVNANLPIVRAAERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9V8</accession>
    <name>A0A231H9V8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEP-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK</fullName>
            <ecNumber evidence="2">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaK</name>
        <name evidence="2" type="ORF">B7C42_01937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784043.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45645">
        <property type="protein sequence ID" value="OXR45645"/>
        <property type="gene ID" value="B7C42_01937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="8"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="35264" checksum="CCA46A9954F7EF68" modified="2017-10-25" version="1">MPALFLLEPGQGPEVSLQGFVRRHPWVRLTTDPLFVHHDRGAPTRRVALVSGGGSGHEPMHVGFVGMGMLDAAVPGKVFASPHNRQVYEASKAVARDGGVLHIVKNYTGDKINFGIAAERLAADGIDVERVLVDDDVATESDETATGRRGTAATIVVEKILGAAADRGDTLTSLAALGREVAGHSRSIAVATEALTSPNTGARAFELEPDQLEYGVGIHGERAATAITRPPLAELVDRMLTDILTSLPGDDRKPLLLLINGLGATTELELCTVLELAARALGDRGRDIAAVQVGTFVAALDMSGFSITLTQLADGWIDLWHAPTGAPAWKEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9V9</accession>
    <name>A0A231H9V9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein YdfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydfJ_3</name>
        <name evidence="8" type="ORF">B7C42_02045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45753">
        <property type="protein sequence ID" value="OXR45753"/>
        <property type="gene ID" value="B7C42_02045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="220"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="717" mass="74176" checksum="F77954ECE491B90F" modified="2017-10-25" version="1">MTETQVVSPPAATTRGPGGLLSRLGAAMAGHTRIVFGVWLLVLVALGAAAPSVFNSLAGAGWQANGSDSVRVRELAQQHFGGNSSAAVQVVVHSDSRTVESPEVQSVLGRMTAIFAGDSRFGEVVAPQPGMSISPDGHTGILIAGAAASTDDMVKAVDAHKDALTALSGNGIEVYPTGASALWSDFNKANHDAMLKAEMFSWPVTLAIMVVAFGSLVAAGLPLLLTLAGLIASAGGLVLLNHVTPISVWAMNFAMMFALALGIDYALFLVARFRGALAASSDPRAAVAETMSTAGKAVVLSGLTVLVSLSAVLIVPAPAVRTMAVGIMFAVAFVLLATLTLLPAALGALGGRINAGSLPRIGRQPHRSPRFAAWGRILHDRPWPFAIAALLVLVALAIPVTGLKVAMPSIQVVPADAPVRQGYELVQAQMGEGAPGMLQIIAPATESGAVANAASAVDGIAMVTPPQPARDGSGLAMMQALPNVDPSDARMATILDHLRDRLPAGALVGGAPAENLDLQHALNHYFPIIVGIILVLGFALLLVALQAPLIAALGTVVSLLSTAAAFGVAKLIFQDGHGAGLLGFRPQGFLDGWGPVFFFAMIFAIAMDYTVFLLATAKEHYERSGDPSRALVDGLAHSGRVIFAAAAVMVAVFFTFSLADPLPPKEMGIILGVAVLLDAVAVRLVQLPVLLRLTGHRAWASPRWLRRILPSISFAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA07</accession>
    <name>A0A231HA07_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase</fullName>
            <ecNumber evidence="2">1.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45793">
        <property type="protein sequence ID" value="OXR45793"/>
        <property type="gene ID" value="B7C42_02085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29462" checksum="23F5F03F81C48696" modified="2017-10-25" version="1">MKIGVNTFLTDEGIGPRVLGPALEERGFESLFLAEHSHIPASRETPYPGGGELPRVYYRTFDPFVALAAVAVVTERLVLGTGVTLLIQRDPIHTAKEVATLDHLSGGRVVFGVGVGWNREEMADHGTDPRTRGALLDEQLAAIRAIWTQDLAEYHGRFVDFDPIFAWPKPVQRPHPPIFVGGGEVAARRAVRLGIGWVPNGVADPSEVPAQLAAVGDSDIPIAITPVAPEPALLDAYAEAGVERVTLSLPTLPESESLRALDEFAAVAERYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAP0</accession>
    <name>A0A231HAP0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mraY_1</name>
        <name evidence="7" type="synonym">mraY</name>
        <name evidence="8" type="ORF">B7C42_02214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502335.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45921">
        <property type="protein sequence ID" value="OXR45921"/>
        <property type="gene ID" value="B7C42_02214"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="37930" checksum="FA9746AF114C1BF7" modified="2017-10-25" version="1">MRQILFSAAIALAVSITVTPLLIRLFARRNLGQQIRVEGPQSHQAKRGTPTMGGIAIVAGLWAGYLGSHLIGLRYDADGPSASGLLVLGLATALGFVGFLDDFIKIRKHRNLGLTATGKYIGQIGSAVIFGILALRFPGSTGLTPASRQVSYVRDWPTVAFPLVVFLLAVCFVVVAWSNAVNITDGLDGLAAGSMGFALGAYVIVTFWQYTNSCAAHALPGCYSVRDPLDLAVVCAAGGAACIGFLWWNANPAKIFMGDTGSLALGGLLAGISITTRTELLMVVVGALFFAEILSVALQIAVFRTTRNRLFKMAPFHHHFELGGWPETTVIIRFWLLAGIAAAVGLALFYAEYLAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBF5</accession>
    <name>A0A231HBF5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_01240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46274">
        <property type="protein sequence ID" value="OXR46274"/>
        <property type="gene ID" value="B7C42_01240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="378" mass="40888" checksum="380E11C3819B635B" modified="2017-10-25" version="1">MTAHAEPGGEPARPARRRFRWLKWVLGVALSALLIAEGVYLWPRLHDSWRNLTEIHWGWVALCIWMQALSMSGFGRIQKRLLRAGGVDVSQRASVSVVYGATAMSVSLPAGQVFSTAFTYRQTRRWGASAIVASWQLLMSGVVATSGMLLLGVGGALLVGNRVGPWKLALMLGTVALLVWAGKYVSGNPGALQALVRRGVRLVNRIRRHPADSGLAHVDEVLHQLESVDLNRRDVAWVAFWAVVHRLGDVACLGAACYAVGADPRWAGLLIAFSVGKAVGTIPFAPGGIVYVDATLIYSLTAAAGLPAAQAVAAAFVYRMVSFILVAIVGWIVFAFRFRNPQLGDAQFEEEFERRSALLAEPRRADGGDKRPDGEPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBW2</accession>
    <name>A0A231HBW2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminoacrylate hydrolase RutD</fullName>
            <ecNumber evidence="3">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rutD_2</name>
        <name evidence="3" type="ORF">B7C42_01336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46370">
        <property type="protein sequence ID" value="OXR46370"/>
        <property type="gene ID" value="B7C42_01336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="33"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="35493" checksum="D7D6A24337A0DE65" modified="2017-10-25" version="1">MSTTNATRVTVCADDGTPLAAWTFGPSTASVTVVFVHGHCLRTESWWFLRDQLLRQWGSGTRMVFYDHRGHGDSAGADPMTYTIDQLGHDLDAVLRAVAPTGPVVLVGHSMGAMVVLAYARLFPATIGTRVVGVGLIAGAAAGITAVGLGRLLNRHTVTSLRVAVQRAPRALQVSKRLGRRVFEPMVREASFGSRRVNPRMAALATAMLNDTPLPTMAYFLDSLIHFDETPTLRLLSDLPALVLGGSADIMIPFAHSVVLAAQLGRAELVRLDGAGHSVILERAEEVAVAVAALVDRATGTPALTPEGRGADTAALPVLAALVGMESPSVTATLPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC25</accession>
    <name>A0A231HC25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46247">
        <property type="protein sequence ID" value="OXR46247"/>
        <property type="gene ID" value="B7C42_01213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="160" mass="17300" checksum="56025CE8AFDBFEDB" modified="2017-10-25" version="1">MSTTSRENDPSQVFRRYLSSVVLHAQAGAKAVGLGATDLYALNILELSGAMTPGELGARTGLTTGPTTRLIDRLEQGGYVRRAPDPADRRKVIVEPVDRPAGLDSALAPARRRIGDIVRGYSPEQRELLFDYFARAADAYQRAAEDITAEEVTEAEAPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC45</accession>
    <name>A0A231HC45_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036496958.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46514">
        <property type="protein sequence ID" value="OXR46514"/>
        <property type="gene ID" value="B7C42_01484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="26533" checksum="AAF39B8BBD681B31" modified="2017-10-25" version="1">MEISGSAAIITGAASGLGAATAQRFADQGATVFGLDLTQSIERAGDSVPAGVTLIPTDVTSNDEVAAAVAKVVESGVPPRIVVNCAGVGWAGRILSKNGPHDLELFRTVITVNLLGTFNVMRLAADAISKTEPVDEYGQRGVVINTASVAAFEGQIGQIAYSASKGGVAGMTVPAARDLAQFGIRVNTIAPGIIDTPMLAGVTEEYRKGLEAGVPFPSRLGRPDEYAQLAQYITEHDYLNGETFRMDGALRMAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC78</accession>
    <name>A0A231HC78_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46543">
        <property type="protein sequence ID" value="OXR46543"/>
        <property type="gene ID" value="B7C42_01513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="22701" checksum="DE6B73EE103A29D3" modified="2017-10-25" version="1">MVDRVSDSAKSEPAGSRRSEKSRQAILTATRDLLSEVGYRKVSIEAIAARAGVGKQTIYRWWPSKGAVIFESFLDLSDTGGEGISLPDTGDIEADLKLVMRATVAEFADAEFEKPVRALNTEIINDPELAAQYDRQLRRPVDDAKKARLRSAQAAGQVRADADLDLMLEMLYAPVYQRWLLRYGPLDDAYADALVEHTLRAFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC84</accession>
    <name>A0A231HC84_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46455">
        <property type="protein sequence ID" value="OXR46455"/>
        <property type="gene ID" value="B7C42_01421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="206"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="33523" checksum="842E527B8699951A" modified="2017-10-25" version="1">MTTPNQPNDERNHANGVTERIAPSPIPPRPAPRSGSSADNGSGSSPANPESQGDSAKSGGSAPEAAEAGDGRGSRFEEGWSQLPQREPQSNLNRPGQAPVQGRANSQTSLGGGVKNARTTTDLAAKAARKEAAMVKSVGIDGPTRSIARPELIKDLPDLSDLRHPMPQADPGAAQSVPMAVKTGAPTVSPAAQAAVAQAVTSGEPLRATVQVRHIDPWSTLKVSLVISVAMFFVWMLAVGFLYIVLSGMGVWDRLNSTFTDMVNDNNSSATTIIDAGSVFGYAAVIGLINVVLFTALSTVGVFIYNQCTDLVGGVQVTLADPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCA4</accession>
    <name>A0A231HCA4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">dnaA</name>
        <name evidence="15" type="ORF">B7C42_01415</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781821.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46449">
        <property type="protein sequence ID" value="OXR46449"/>
        <property type="gene ID" value="B7C42_01415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="376"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="588"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="184"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR46449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="682" mass="76191" checksum="BB4111DC69A489E8" modified="2017-10-25" version="1">MDDEQNVLTAVWPEVVAELTAGSTDGAIPPVTNAQKAWLGLVKPLTVAQGFALLSVPSSLAQEAIERDLREPILRSLARRLGPQVEGLGVRIAAPANPPPDRPGAGARHARLTSRPERMRDKPREPVGFPAPPQYPDADDFPTPRYLSPADYQARTAYPQGEYPSAPMAGELPDSLGPSSPLRRDPDAHLHDEALVRHPDSLRRDPDDLRRDPDAFRHDPDALRRETDALRRDADTLSGRDGLHGPDSLRREADSLRRDHELHHPPEALRREPEPLRHDQELPRAGGHPGQESLFAPEPEVGQRPGVAEDADEPVVSARNSWPTYFAKSPEPPAPAPASSSASLNAKYTFETFVIGASNRFAHAAAVAIAEAPARAYNPLFVWGASGLGKTHLLHAAGHYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRRYRETDILLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVVSSDRPPKQLATLEERLRTRFEWGLITDVQPPELETRIAILRKKARMDRLDVPHDVLELIASRVERNIRELEGALIRVTAFASLNGQPLDLSLAEVVLRDLMPDTTTIEITASTIMAVTAEYFNTTLEELTGPGKARPLAQARQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAEKKVRKEMTERRRVYDQVQELTARIKQRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCN6</accession>
    <name>A0A231HCN6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46671">
        <property type="protein sequence ID" value="OXR46671"/>
        <property type="gene ID" value="B7C42_01646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="118" mass="13056" checksum="CE0760AE05EC83B3" modified="2017-10-25" version="1">MEIMGVIAELTKLSAAAGASPQARAECERLAKKGEQYAKTIAPVNKTGRPHRLPSGYVDNPGDYRDSIRGETLFKNGKWRGRVGAYDYKSHWIEYGTSKMPKQSIMRRTAGHLRGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD23</accession>
    <name>A0A231HD23_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46696">
        <property type="protein sequence ID" value="OXR46696"/>
        <property type="gene ID" value="B7C42_01671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11990" checksum="A1D1D0DAD5A9737E" modified="2017-10-25" version="1">MSAGTSSSLRTAIQCIRPDLTANFVVDIQQMTDLLIRLGYEPGPVITINPYLHGPLTTVMTAIAEHGPDAVIVPDFEHIDGLDRLIRERAQLIVADSGRVSERIPSKVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD71</accession>
    <name>A0A231HD71_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775529.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46854">
        <property type="protein sequence ID" value="OXR46854"/>
        <property type="gene ID" value="B7C42_01832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="182" mass="20988" checksum="7864E608FC9F7FFA" modified="2017-10-25" version="1">MSGFSRDELDEMVRRWVVENERCEAAGDWRPLADMYTEDATYGWNYGPTQEFMAVGREEIRELALGQEMDGLEGWTYPYQEFVVDERSGTVIGLWKQVNENTRPDGRHYSPEGIGGSWFRYGGNFQWSWQRDFFDFGNVSALFVEMITANALSEGMQKRIERSGAGPLPGWYKIGESPVPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD86</accession>
    <name>A0A231HD86_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46772">
        <property type="protein sequence ID" value="OXR46772"/>
        <property type="gene ID" value="B7C42_01750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="42589" checksum="7C280391A2E5195D" modified="2017-10-25" version="1">MTTEADNPLIAQREDSTKWYTGIGVAESVADIHDAISSGSWVDGGLAVLGAGMEAVSLAVDPLGTLASYGVGFLMEHVEPLQEALDWVAGDPDTVQAYAKTWENVSTHIEQVADDHKKSVDQDVADWIGSAGDAYRTHAAETNALLTAASNAASAASSAIEMAGGVVAFVRQTVRDLIAQAVGRLAAWAAEEVCTLGVATPLVAAQATTFVAKVLTTIAELFRKLASTFKKLTPLLHKLKGAWEDIMKALKRGRGGTQIDGAKPHAKSPADTHPSSHKPDSPSEHGKPHDDGADTHSTSHDGSGDPDDGATGKPKNDPHQQADKDQGSGTHAAESGPNPERPPRIPQQPPDPQRPNPLLLRRGWAFDPEGSHAAVPQAGHLALPVQRVRSADGCVYAGEGVVEIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE14</accession>
    <name>A0A231HE14_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46985">
        <property type="protein sequence ID" value="OXR46985"/>
        <property type="gene ID" value="B7C42_00101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="3">
        <location>
            <begin position="209"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="36272" checksum="DC1A8AFFB1AD405A" modified="2017-10-25" version="1">MSKQVAADLGVTAVTVGKWRQRFVESRLDGLNDSPRPGRSKAGLMLTEEERSTLQRWARRPKTAQAIAFRARIVLACAEGVTNKQVAAALGTREQTVARWRGRFVRNRLQGLVDEPRPGAPRTISDDDVEQVIVKTLEHVPAGGDTHWSTRGMAKATGLSQSAVWRIWRAFWLKPHMVVTWKLSTDPQFIDKVRDVVGLYLDPPAAALVLCVDEKTQMQALDRSAPMLPMMPGVPARRTHDYVRHGTTSLFAALDVATGKVIGQHHRRHRHQEFLRFLKTIDADTPAELDLHLICDNYGTHKNTRHQQMAGSPPAIPPAFHPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEB4</accession>
    <name>A0A231HEB4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47290">
        <property type="protein sequence ID" value="OXR47290"/>
        <property type="gene ID" value="B7C42_00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="11867" checksum="536643B3F567B60E" modified="2017-10-25" version="1">MTEGETAELSAEDGKLLVLARGAMGRTGGVAGAAIRDTDGRTYAAGTVDLNALSLSALQAAVVAAISSGAEGFEAAVLVGGQDGDPGVAAVREVSASAAVIVTDRKGATYRTVDAGTETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEG2</accession>
    <name>A0A231HEG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-inositol 3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.250</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mshA_1</name>
        <name evidence="5" type="ORF">B7C42_00454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47331">
        <property type="protein sequence ID" value="OXR47331"/>
        <property type="gene ID" value="B7C42_00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="208"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="42952" checksum="4E6798BABFA6B387" modified="2017-10-25" version="1">MKIAMVSEHASPLAPLGGVDAGGQNVHVAELAAGLARLGHDVRVYTRRDAPDIPAEVLVGAGYRVIHVPAGPPCHIPKDEIVPFLTEFAAFLRRQWSADTPDVVHAHFWMSGIAAERAARDLAVPVVLTFHALGTVKRRYQGLADTSPRSRIQSERRVAAGATHIVATCSDEVRELGRMGVPRERTSVVPCGVDLSLFTPDGPAEEPDLPRRIVSVGRMVRRKGFDSTIAALSEVPDTELVIAGGSQSAEDEAEQARLRAVAAEYGVSQRVRLRGPVPRAEMPMLLRSADAVVCTPWYEPFGIVALEAMSCAKPVVATAVGGMLDTVLDGVTGRLVPSGDPAVLAEVLSGLLDTRQARQAMGEAGLQRARGRYSWDRISRDTSAAYRRTAATAAAGDIASSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEP3</accession>
    <name>A0A231HEP3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative thioredoxin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxC_1</name>
        <name evidence="6" type="ORF">B7C42_00327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47205">
        <property type="protein sequence ID" value="OXR47205"/>
        <property type="gene ID" value="B7C42_00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16131" checksum="99570ACBAACDE6FB" modified="2017-10-25" version="1">MPTQPLTQQNFEQVIATRAIVLVDFWASWCGWCTRFAPIFADSAAAHPEIVHATVDTEAEPALTAAAQITSLPTLVAFREGLLVYSNPGFQTAAQLEEVIQQIRWLDMDEMRRELGVQTPAVTAPAPPMARAGAATGRPSYGWPGLNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEZ7</accession>
    <name>A0A231HEZ7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpsT</name>
        <name evidence="8" type="ORF">B7C42_00369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777096.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47247">
        <property type="protein sequence ID" value="OXR47247"/>
        <property type="gene ID" value="B7C42_00369"/>
    </dbReference>
    <dbReference type="GeneID" id="66720904"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="9469" checksum="F658B66959818A45" modified="2017-10-25" version="1">MANIKSQMKRIRTNEAARVRNQSVKSALRTSIRKFREAAAAGEKDKALELMRSASRSLDKAASKGVIHANQAANKKSALSLAFNKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF51</accession>
    <name>A0A231HF51_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47307">
        <property type="protein sequence ID" value="OXR47307"/>
        <property type="gene ID" value="B7C42_00429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="15"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="17833" checksum="D674EB9CB0740E9A" modified="2017-10-25" version="1">MSDRDRGGRRFAAVHLTQIRLIVSEFDRCVAFYRDVLGLTPQTDDPRPPYAAFKPELGSTLALHERANLAAALGDTLRSGIDARPASGGDGAPAPAADTAMVSLRVDDLDDYLAVITARGAEISGEPVEYDGRLRCAYLRDPEGNLIELQQWLATRTGEAVPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFF4</accession>
    <name>A0A231HFF4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter glutamine-binding protein GlnH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glnH_1</name>
        <name evidence="4" type="ORF">B7C42_00826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779498.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47701">
        <property type="protein sequence ID" value="OXR47701"/>
        <property type="gene ID" value="B7C42_00826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011256399" evidence="2">
        <location>
            <begin position="32"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="39"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="29397" checksum="8A12681B3E4BD54D" modified="2017-10-25" version="1">MRITRALRFGIGALAIAVVASGCGGGSNKTATEHASEGKLTIGIKFDQPGLGLRNRDGSFSGFDVDVATYVAGKLGVSPDKITFKEAPSAQRETLIQNGQVDYVVATYSITDQRKQKVDFAGPYYVAGQSLLVRADNTDITGPESLKGGKKLCSVKGSTPAQNIQKNFANDVQLQEYDTYSLCVEALKSGAVDAVTTDNIILAGYAAQSPGQLKVVGQPFTTENYGIGLKKGDKDSRDKINDAIESMINDGSWKASLEKNFGNAFPIPSPPQVDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFI5</accession>
    <name>A0A231HFI5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Doxorubicin resistance ABC transporter permease protein DrrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">drrB_1</name>
        <name evidence="9" type="ORF">B7C42_00724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47599">
        <property type="protein sequence ID" value="OXR47599"/>
        <property type="gene ID" value="B7C42_00724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="24"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="29442" checksum="D08D33418C9F5184" modified="2017-10-25" version="1">MTVRIQAMPRRGAHAVLRGWWLPCWVLTRRQIRPSLRNGEVLTAVLAPTVFTLGFYVPLNRVMSFAGHGASSYAQFLMPMIVMQAVSFCASAAALRAAVDARDGLDARLATMPIPSIAPLTARTAATGYRVVIALAAALLAAHVIGFRFGGSNWETLGFLLFSVSVGVMLGLFGDLLGALSKSPEATTQVLMLPQLILGMVSTGFAPASQFPPWIQGFARNQPVSQFVDAMRALAGDKPGFATAVDRSTIGPGVMWTVAGLLVFGAGSVVLAVRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFP9</accession>
    <name>A0A231HFP9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47546">
        <property type="protein sequence ID" value="OXR47546"/>
        <property type="gene ID" value="B7C42_00671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012330569" evidence="2">
        <location>
            <begin position="37"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="24671" checksum="9168FB9B8575F4FE" modified="2017-10-25" version="1">MVRTGFGRGKEKMRKMIAASALLATTLSVAPALAHADPAEAGAVNYTATTTPTSTIIRTDSGSLTDEAGVFRIKAADGTVLAGTELSFRVDDFVFPIAADISGHTATLTPQLDLAHATYRPVALPYEDQAPWKTPYDREQAAWTRLTSTIGAGATIGTLIGGLSGGAIGCLLGGIAGATVASATIVGLFGPFVPAAVVGCVGGIVAIGALGTLIGQLLVTAPVAILAAAQYFTTINQPFTKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFS6</accession>
    <name>A0A231HFS6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47557">
        <property type="protein sequence ID" value="OXR47557"/>
        <property type="gene ID" value="B7C42_00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="16"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="470" mass="50392" checksum="00EC8C320E81BDF2" modified="2017-10-25" version="1">MTDTSQPTKVPRLPTLTGMRFAAALLVFCTHVSLEGFFADAGAADTASFLVKRAGWTGVGFFFVLSGFVLAWSARPGDTTVGFWRRRAVKIYPNHVLTWAIAFALLLWTGKTVTAGVAIPNLLLVHTWLPIVQNFASMNTVAWSLCCEAFFYLLFPWLLAAVNRIRAERLWAATIAVIAVIVVLPLIAQLLPDRPRVPFAPDVPVYQFWFVYLFPPVRTLDFLLGILLAKLLLSGRRAPLSLAPATGLAVLGYVGLLYAPYLFALDAVTIVPIALLILAGARADVRGTPSLWRARFVVWLGDISFAFYMIHELVLHYRVRLFGIQAAWSTPVALAVVLGLLVVDVLLAWGLYSAVESPIVRRWSRPRRRESSLPAVSTATLTSLAGVAADTGRSADAAGARGGAAAPSIAVLDSPAAVSDSPVAEIDSPPAVVDSPVAVLDSPAVPDSPAAVLDPPAAVRESPAVDGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG60</accession>
    <name>A0A231HG60_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">rnj</name>
        <name evidence="12" type="ORF">B7C42_00800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47675">
        <property type="protein sequence ID" value="OXR47675"/>
        <property type="gene ID" value="B7C42_00800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="153"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="496"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="684" mass="72771" checksum="962684692A6BC711" modified="2017-10-25" version="1">MSEPVNRRPRRTASRAAGAPAPAPPPAPRVEPEKPAVQQVSPPEPARAEPAAERGAATGQRETASAPKRETAPAAQRESAPAQRESAPAQRGDQAGDRGRSRRSGRGRQSGSRGRAEQSAPQPVSTGLPVGLPPKLPKQGLRVYALGGIGEIGRNMTVFEYGGAMLIVDCGVLFPEDQQPGVDLILPDFRPIEDRIDEVAAVVLTHGHEDHIGAVPFLLRLRPDIPVVGSKFTLALVAAKCREHRLQPRLIEVTEGQRTTHGPFDCEYFAVNHSIPDAIAVAVRTPAGLALHTGDIKLDQLPLDGRLTDLAGFSRLGDEGVDLFLVDSTNAEVPGFVTPEREIGPVLDSVIGKAKGRVIVASFASHVHRIQQVVDVAQRYNRRVCFVGRSMVRNMQIAQDLGYLNIPEGIVVDLDQAANLPVHKLVLISTGSQGEPLSALSRMARGDHRQINIRADDLVVLASSLIPGNENAVFAVVNGLARLGATVVTQQSAKVHVSGHASAGELLYLYNAVRPTNAMPVHGEWRHLRANAALAVATGVPEERVMLAEDGVVVDLVDGIASIVGRYPVGQVYVDGLSVGDVGESTLSDRLVLGEGGFIAITVVVDETTGKAVSTPEVSGRGFSDDPGALLGAQELVEAELLRLAGEGVTDTHRIAQGVRRVVGRWVADTYRRRPMIVPTVMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGG1</accession>
    <name>A0A231HGG1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47785">
        <property type="protein sequence ID" value="OXR47785"/>
        <property type="gene ID" value="B7C42_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046134">
        <property type="entry name" value="DUF6131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19626">
        <property type="entry name" value="DUF6131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5393" checksum="481994932E275587" modified="2017-10-25" version="1">MIILGVILLVLGFVFSIPILWTLGIIAVVIGAILALLGAFGRPVAGRAHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSG5</accession>
    <name>A0A231GSG5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000645">
        <property type="protein sequence ID" value="OXR39544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39544">
        <property type="protein sequence ID" value="OXR39544"/>
        <property type="gene ID" value="B7C42_08388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="6511" checksum="9A688D49848AA544" modified="2017-10-25" version="1">MLVGRSYALPGAVTIEVRKRGTALLNCAPVAAPSASSASWVSRSTSAHHAATSPSTTPACSTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSH7</accession>
    <name>A0A231GSH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000417">
        <property type="protein sequence ID" value="OXR39566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39566">
        <property type="protein sequence ID" value="OXR39566"/>
        <property type="gene ID" value="B7C42_08366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="8935" checksum="1A196213002028CA" modified="2017-10-25" version="1">MLDQIDSLVEACRALRPDSVDGPRDTPWNTRDIEVRTPENARVIMTAAKPFDPAGPEARNLAAVGITAPEEVAGDNAEHARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT46</accession>
    <name>A0A231GT46_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH IS21-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_08126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000063">
        <property type="protein sequence ID" value="OXR39797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39797">
        <property type="protein sequence ID" value="OXR39797"/>
        <property type="gene ID" value="B7C42_08126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="5">
        <location>
            <begin position="264"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR39797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="498" mass="56063" checksum="3480E8CC5C84AD06" modified="2017-10-25" version="1">MFSSLSALVIDAVGDEGSRIVVRARTAPGPAVCSRCGAESAKIHSYHHRTVADLPVDGRVVVLRVRVRRLVCPTPLCCRTFREQVPGLLERYQRRTARLTGQVRAVVRELAGRAAVRVLAALPVRMSRHTAVRVLLRIPLPHRPIPPVVSVDDFALRRRNRYGTAVIDAVTHERIDVLADRKSDTLEAWLHDNPGVEVVVRDGSTTYAEAIRRARPAALQVSDRWHLWHGLARSVREVVAAHGRCWAASGPKRQTLTRETTTLERWHAVHDLLDQGVGLLDCARRLGLALNTVKRYARASEPDQLRRPPYYRACLVDPYRDHLRQRRTEQPGVPVLHLFHEIKALGYTGSLNLLHKYLNQGRAENDRIIPSPRRLTSWIMSRPTDLPAGRRAHLDELVAACPEMTDLARLVGEFASILAERRGSDLDGWMKQVREARLTELDPFLRGLDQDHDAAVAGLTVPYSNGPIEGVNTKTKLLKRQMYGRASFELLRHRILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTC7</accession>
    <name>A0A231GTC7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000076">
        <property type="protein sequence ID" value="OXR39731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782047.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000076.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39731">
        <property type="protein sequence ID" value="OXR39731"/>
        <property type="gene ID" value="B7C42_08192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="95" mass="9934" checksum="B71368AD78026237" modified="2017-10-25" version="1">MSPRRGRARLGTYNSPYFHGYRSTSPSPILAFLGALVGGVVLLLVVLPLTHAHTTHTGGDTAPGQVTTSVVAPPRVLPTTAATPAHPCYPFEPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTE1</accession>
    <name>A0A231GTE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39825">
        <property type="protein sequence ID" value="OXR39825"/>
        <property type="gene ID" value="B7C42_08113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="34" mass="3720" checksum="2AEE78788E230C40" modified="2017-10-25" version="1">MAAYTAEHKLCRGQGCPICGYTGEVIRDDDYPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTZ2</accession>
    <name>A0A231GTZ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03628</name>
        <name evidence="2" type="ORF">B7C42_07985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000050">
        <property type="protein sequence ID" value="OXR39951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777259.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39951">
        <property type="protein sequence ID" value="OXR39951"/>
        <property type="gene ID" value="B7C42_07985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44072">
        <property type="protein sequence ID" value="OXR44072"/>
        <property type="gene ID" value="B7C42_03628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="27571" checksum="751D1BC04F54AE54" modified="2017-10-25" version="1">MSTVLVTGGTGALGRHIVDRLRERGHDARVLSRRPGAGTHVGDLATGAGVREAAEGAESIVHAASDFRRFGKPDIEQTRNLLAAAGGARHLIYVSIVGIDRIPFGYYRNKLTCEQLIADSGVPHTIQRATQFHDLIAAVLSGVQKLPIAPLPSDFRFQPVATDDVATRLADLVEGEPRTRADDFGGPQVLTLAELAKTWQQHHGRPRRTVRLPLPGTIAHAFRAGYNTCPDHADGTRTWAEYVAADPGPSYRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU86</accession>
    <name>A0A231GU86_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_07813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042638.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40105">
        <property type="protein sequence ID" value="OXR40105"/>
        <property type="gene ID" value="B7C42_07813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="148"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="325"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="435"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="813"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="895" mass="99900" checksum="8D4F14329B0BF508" modified="2017-10-25" version="1">MALHLTDLRVNSLTEPIGVHTPRPEFSWKISTSEPGILQSACALQVCRDGGRFEGADLLWDSGRIPSDRPFGILYQGHRLQSRKRYLWRVKMWDNTDTASTWSEPATFETGILDPELWTAQWVTGPPPSPHAEDTPLYFRGQLDVTAEVVRARAYVSALGWYRLFVNSTDVTGNALVPRWTPLDEIVEYQTYDVTDLLRNGRNALGVVVADGRYRGRSGAFARRAIYGDQLAAFVQLHLELADGNTEIVTTDHTWRAGTGRILHSDPMYGESADLRISESEWLDPAAPLPGFTPVRTITSKRQLVGEAVARVQETRLLEPAAITRTPSGKQLVDFGQNFAGVTRIHLPGRAGLQLQLTHAELTTSDGELDTLSFVTSKKRPWYQRDKVVTGPSATWYQPWFTIHGFRYVEIDGLDEDLRPEDVRGVVLSTDLTSAGTFECSDSRLEQLHRNVEWSLRSNFVDTATDCPTRERSGWTGDLQIFAPTATMFADVQAYIRRYLANLAVEQLPSGGVPPYVPSEQSAHQMGKLNPFTRFAATRVLEALAGSAGWGDAAVLLPWTLFRYYGDTEILRQQWSSMTRWVDRGARVAATKSRTLRRLRKPAGSLEKYVLDTGFHWGEWIRPGETVLDKARDAMTHRPVVATAYLAYSSRILSEIAAILGYDTDARRYGELAEHVTAAYRAAFVRDGGRRIGRDRQDDYVRSIAFELLSSAERTRAMNRLAELVEAADYHLDTGFLSTPMLLPTLADNGRADLAFRLLLQTTSPAWLYQVERGATTIWESWEGYDADGNGLASHNHYAFGSVAAWLYEGLAGISPAEPGYRVIRIAPRIGGGLTRVAASIHTPFGRAASEWRIDEDRSVHLRVEIPPGTEALVTWDSAGTERRVGSGTHEICWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUE9</accession>
    <name>A0A231GUE9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40249">
        <property type="protein sequence ID" value="OXR40249"/>
        <property type="gene ID" value="B7C42_07674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="27373" checksum="80D0C62917BD3388" modified="2017-10-25" version="1">MTDTTTSTNGAAPTNGAGPAAAQIIPTAELGELMDAVVRKAVSAKFAEKAKDIAAEVVEKLLTPEIREQMAETAAHEAELALNPPVVVEPEPEPEPVVVAEEKPKNEYDNEYDFVQDYVCNVYRREIAGSSRTAKQNFRWCPQWWRHGEARGRLKALWTAFEALRQGETVEQSVFWLTHFGPQMNALMDPEGPFKHCSPEGHNIHGVLAELPMDPWPGETEAEATASGLVVPTGPTVHHQRIIRTDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUH4</accession>
    <name>A0A231GUH4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40242">
        <property type="protein sequence ID" value="OXR40242"/>
        <property type="gene ID" value="B7C42_07667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="60" mass="6308" checksum="0D0E1ACA411AB0CF" modified="2017-10-25" version="1">MSENHHMDKLIEQSSLGTKHAKKMRASVSAATGRAIVRAAAARAQTSKTTNGGASKKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUI7</accession>
    <name>A0A231GUI7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778636.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40141">
        <property type="protein sequence ID" value="OXR40141"/>
        <property type="gene ID" value="B7C42_07805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011301471" evidence="2">
        <location>
            <begin position="27"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="24772" checksum="4D0FDC399266A64B" modified="2017-10-25" version="1">MNVRKTTIAAVMAAAVVATATATAGADAPAPAPGSVSAPQAQGVHYDARIEDKTVVATLADGGTFVAAGDSISVRDAAGRTLESLPLSFSFDGERRPIRQEISADGSTLRLTPDVAGLVVRPQVKAVATPLENQLAMNDLINAAAFGLTIGSLVGTVIGTVLGAGVGFVLAGASCVVLSLGCVVAVLPIMALVAGVGGIIGLDIGGAGGVIPAALNYVNTLNAPPGQSIYASQIPALAGNAPGAPQPAPQPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUT4</accession>
    <name>A0A231GUT4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative D,D-dipeptide-binding periplasmic protein DdpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddpA_2</name>
        <name evidence="3" type="ORF">B7C42_07550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40384">
        <property type="protein sequence ID" value="OXR40384"/>
        <property type="gene ID" value="B7C42_07550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012872852" evidence="1">
        <location>
            <begin position="34"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="101"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="563" mass="61524" checksum="65153672EA685FEC" modified="2017-10-25" version="1">MPTFLKPTPHRRKRRWRTGAFALAAATALLASACGGGGHDSGPSGEGRDPVRGGTLRLAFWPDNAAFPCIDPFQVYWIESRSLIRNFADSLTDQNPDTGAIVPWLATGWQISPDGHDYTFTLRDGVTFADGAPLDAAAVKTNFDAFLDETRRTNGTVFGASYIVGLESTEVVDAKTVKFHFSQPNSSFLQATSTTNLALLSPASFRKTPQQRCQGDIAGSGLFVLDKYVPGESVSLSRRTGYRWGSALSKNTGEAYLDGVKVSYVAEDSVRTGNLVSGQIDIAWPRNPFTVEDRQLIARSGAYVRSRPLPGVSYTLYPNVSDGHPLADDQVRAALYKAIDVKTYATTVFGSDYPAVGGPFDSTTPYFVSQAAKLNYDPQEAGRLLDADGWRLAPGDQYRSKDGKRLTLTQLITASSPGAELFQDQLRKVGIDLQLKVVTNAERPGAIAGGQYDLIENYFTRADPGALQYILVEQLANSKALARNAQHPATAARVRDLFTQAVQATDEAQRQRVYTELQNVLIDNGVTFPLFERLQYAGIRNQVNGFRFTSESFLSLADTWIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUW8</accession>
    <name>A0A231GUW8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_24</name>
        <name evidence="3" type="ORF">B7C42_07481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778563.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40423">
        <property type="protein sequence ID" value="OXR40423"/>
        <property type="gene ID" value="B7C42_07481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="403"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="489" mass="52235" checksum="20D508CF82E9725D" modified="2017-10-25" version="1">MGIELILDMAAGAAGDRVALGRRDTGLTYADLARAADGGAALLRKSGARSVAYVGLNGPVLPALIFAAARAGIPLTPLNYRLSGVQLGELLAELDHPFVVADHAYAAVVPADALSEDWLDRALQTEPTEQIPVDDENPAVVLFTSGTTSKPKGVVLRHAHLLSYVLETVEFGAAEGSDAVLVSVPPYHIAGVGSVLSNLYAGRRMTYLPDFNPGAWLHLVREDQVTHAMVVPTMLARIVAELDGAQADTPSLRSMAYGGARMPQTVLRAALKAFPNTDFVNAYGLTETSSTIAVLGPEDHRAALQGDPIALERLGSVGRMVPGVECQVRDEAGEPLPRNTTGEIWVRGGQVSGEYQGVGSVLDSDGWFPTRDRGRLDEDNYLFVEGRADDTIIRGGENIAPAEVEDVLLEHPAVDQVAVLGAPDEEWGERIVAVVVPVAGSDPDPEDLRAFVRARVRSSRTPDDVVFRTELPYTATGKLLRRELARHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV29</accession>
    <name>A0A231GV29_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_07571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40405">
        <property type="protein sequence ID" value="OXR40405"/>
        <property type="gene ID" value="B7C42_07571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11449" checksum="AB9585048635DDDD" modified="2017-10-25" version="1">MPKSMHPSAIAAMKDIYMAGDLDKAQLAVKAFDVGYGAKYPKAVAKIVDDLDVLLDFYRYPAEHWIHLGTTNPIESTFASVRLRTKVTKGPARGRRESPWPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV71</accession>
    <name>A0A231GV71_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40519">
        <property type="protein sequence ID" value="OXR40519"/>
        <property type="gene ID" value="B7C42_07458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="31697" checksum="AA581A81BD4043FD" modified="2017-10-25" version="1">MTSAVNEAREALGLRLRELRRDAGLTGRKLAELAGWHESKTSKIEYGRQTPSESDLHAWCTHTDSLDQLPDLVATLRNIEAAYLEWRRVLGTGTRRRQKLSVKLENEATAMRWYEPTIVPGLLQTPEYAQGILRKIIAFYDIPDDLDEGVAARIERQRVLYHGDHRFAFVIAEQVLHTTVDNDEVMIGQLDRLLTAMALPRVTLGIVPTRAAYEAPATNGFIMFDNKMVHVETTSAELAINQPREITQYGRLFSRLTELAVYGDDARELIRVEIDRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV85</accession>
    <name>A0A231GV85_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid-associated protein Lsr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lsr2_7</name>
        <name evidence="2" type="ORF">B7C42_07437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40498">
        <property type="protein sequence ID" value="OXR40498"/>
        <property type="gene ID" value="B7C42_07437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="89" mass="9933" checksum="EC8B9DC37BE7D22F" modified="2017-10-25" version="1">MSRSLRHDYRRGLGTAKNAAALRQVFEKWSAATRQIGRIPKGKSTVGARKSVDREQTAAIRDWARRTGYTVANRGRIQASIVDAYNKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV91</accession>
    <name>A0A231GV91_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40543">
        <property type="protein sequence ID" value="OXR40543"/>
        <property type="gene ID" value="B7C42_07352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="685"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117007" checksum="24DA5AF65847E7E4" modified="2017-10-25" version="1">MLDIRADDGEVIEVPGARLRALLIALALEPGRAVPRTTLVDWIWGEQPPADAANALQALVSRLRRVLPDGSLDGQAGGYRLAVDPGAVDALRFERLLDQARGGDVVRQTHLLREALGLWRGAPMQDIDVRDSEAVAAVVTRLEGLHLAALEDLYDAEIRLGRGAELVAELTELVARHPVRERLIAALMRALAAAGRGAEALLVYQRAREALADTLGVDPSPELSDLHVALLRGEAGPRDNERKTNLRAELTRYVGKYTDIAAVRELLANHRLTTLTGPGGSGKTRLALETARTLLDDLPDGAWLVELAAVGADGDVAQSALAAFGLRDALLGGAPDAEPVDRLVAAIRDRETLLILDNCEHVIDSAAAFAHRVLGECRGLRILATSREPLGITGEALWQVAPLALPAADATPAEIESSPAVQLLRDRAAAVRTDLETTDPATLSTIARICRALDGIPLAIELAAARLRTMSLDQLADRLDDRFRLLTGGSRTAIAQHRTLRAVVDWSWELLTDAERTVLRRLAVFAGGASLEAAERICAGASDAPGDVEQREVLELLTALTEKSLLLTSPDTEPRYRMLETIRRYAYDRLVEAGETEQIRRQHLSYFTTLAETAEPHLRRAEQLEWLAKLEAEHDNIAVALRGALADDDAAGALRLAAAAGWYWWLGGHKAEGMELITAAARIGGHEGGSEASPRSALDSAADNPARSGGHEGGSESSRTADGSGDDEFRARVYGLIVHFMSSGPNDEHQVAEWVHKAYQLGRNSESDYPLLAFIGALQRMLRGGDEFLTAFEPLLTHDDPWVRALARLQVGKARIALGFPGREADDHLETALAEFRALGERWGMSFALTELANRIAMRGEFATACAYLDEAIAVVTEVRAIEDVFLIRARQAQLYWLQGDAEASADAMSEAQRYADRSAWPNALAEFAFTKAELARWQGDTEQARRQIEIATSAQGGDADQSYVDALRNHQLGCLTTDLNVARTLHAAAFRAATGAGYAPLTALIVVGIADLASRAEQDEQAVRLLAASAAIRGLVDRSQPDVARIEQTARRRLGDQRFTEATKEGAEAEWEELVAATLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVK5</accession>
    <name>A0A231GVK5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40501">
        <property type="protein sequence ID" value="OXR40501"/>
        <property type="gene ID" value="B7C42_07440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="11469" checksum="FAF87EDDDEF1126C" modified="2017-10-25" version="1">MVDQMRVDPVKLREASRFVADKAQVMRERLKTLDDTVGKRLLAEGWTGSAASGYDGSWTEWKKGAAVVIEALDESSFKLADAANVYEAQENRNSGGIQQCSLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVV6</accession>
    <name>A0A231GVV6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40763">
        <property type="protein sequence ID" value="OXR40763"/>
        <property type="gene ID" value="B7C42_07187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="14349" checksum="C829748453A9859A" modified="2017-10-25" version="1">MIRTPLTPITGQAVGILADGAVKILLAVVYIVGVESLSHRLGVAAWLLIACAAALLVAGGSELAYLRSRAVSTYMRLMIGYDSGWSIVTAVALLLAWQGNRTAGELWIGYQTIAPLAFIALLVMADGRDPAGLGGAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVW3</accession>
    <name>A0A231GVW3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518953.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40705">
        <property type="protein sequence ID" value="OXR40705"/>
        <property type="gene ID" value="B7C42_07263"/>
    </dbReference>
    <dbReference type="GeneID" id="66724208"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="14951" checksum="8F76AE31726E6A25" modified="2017-10-25" version="1">MASTTVDTVIPAPRDVVYKLFAERDSLNGYLPVRITLRQPGAPEASGVGARYLVGVGGIGVTEETTELVPGERMEYRIIAGAPVKRHVGTITFADAPGGTLVSYRMESEPKLPVPDKATELFLRGLISPFLKAAKKAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWC6</accession>
    <name>A0A231GWC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043741.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40906">
        <property type="protein sequence ID" value="OXR40906"/>
        <property type="gene ID" value="B7C42_07041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="17388" checksum="4BF59DD17A1FE07F" modified="2017-10-25" version="1">MEWASVGLDNCPVVRALEVVGSRWTLIVLRELFNGVRRFEDIQQHLGVSTSVLSKRLADMVDQGLAERQPYRADGRRERYEYLPTAKAWDLYPVVVGLMQWGDRYLADPAGPPVRLVDGRTGREVVAAVVPADTPACDPADIEVIAGASIRRVAGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD2</accession>
    <name>A0A231GWD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40940">
        <property type="protein sequence ID" value="OXR40940"/>
        <property type="gene ID" value="B7C42_06906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="19709" checksum="2625CE03987F3461" modified="2017-10-25" version="1">MTEQEVVVDRAGLWDAEELSDVATATFPLACPPELTEENIDTFIAEVLSGERFGDYLSDPRRIVLKAVLGGDIVGYTMLISGEPVDPVVAALIEARPALEISKMYVVPGHHGGGVSTALMNAAVDYARRGGYPVIWLGVNQRNERAQRFYGKHGFRRIGTKTFTVGDQVCHDFVMRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWG5</accession>
    <name>A0A231GWG5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">sigA</name>
        <name evidence="9" type="ORF">B7C42_06936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779400.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40970">
        <property type="protein sequence ID" value="OXR40970"/>
        <property type="gene ID" value="B7C42_06936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="397"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="462" mass="51308" checksum="B63076D3A9B12CF7" modified="2017-10-25" version="1">MVATNTRQTAESAEAADSAEGTAARPVRKAAAKKAPAKKVAAKKAPAKKAGAKAAKKAPAKKATTKKAAPGADNESDEHIDDESLELDDLGDLEVSEDDLSDEGEDLVEETADEEAEAEDEEADEPSEKDKASGDFVWDEEESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATEKLREFADKGEKLPVATRRDLQWIMRDGNRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWN4</accession>
    <name>A0A231GWN4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_14</name>
        <name evidence="4" type="ORF">B7C42_07046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40911">
        <property type="protein sequence ID" value="OXR40911"/>
        <property type="gene ID" value="B7C42_07046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="445" mass="48213" checksum="7FF017ECF63B09CE" modified="2017-10-25" version="1">MARRRIHLNVNILNAGVFGGAWRFPGADPEASFGLDHYVRIARTAEAGKFDAIFLADGPALRDDIRFRPFNSLEPSVILAAVAAATERIGLIATLSSSYNDPYDVARRFATLDLLSGGRAGWNVVTTAGAESARNFGYDDEFDHTTRYRRAAEFVDVVRKLWNSWEPGALVGDKAAHRFADVDRIHRIDHRGEFFDVAGPLNVPRSPQGEPVIVQAGASDAGRALAATVGEVIFTAAQTVAEASEYRRDVSARAAAAGRPPGSFLVLPGLSTVIAATEREAAERRALLDELVPTEYALQRLADQLGVNPEVLQPDSPLPFDKLPDSRVAGGSHTFRRVAVDLARRENLTVRQLLRHLGGGLGHRIVTGTPEQVADTIVEWVEAGVADGFNLMPDVLPGGLDDFVTGVVPILQRRGVFRTEYSGSTLRSHLGLPIPEPIRTPEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWZ0</accession>
    <name>A0A231GWZ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cynT</name>
        <name evidence="9" type="ORF">B7C42_06736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 8"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783050.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41140">
        <property type="protein sequence ID" value="OXR41140"/>
        <property type="gene ID" value="B7C42_06736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="19998" checksum="BA92DA3658D42416" modified="2017-10-25" version="1">MHDLTTGVTHFRDAVFPAKAELFAQLTTTHTPGTLFIGCSDARVVPELITSSEPGELFVVRTAGNLVPAYGPGSDGVAASIEYAVAVLGVERIVVCGHSGCGAMTALAERHDLSTMPTVAAWLRHADAAAARPGSAAIASLIRANVVAQQANLATHPAVARALSTGAVTVEGWVFDIGTGTVTVIDPAGSDRTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX63</accession>
    <name>A0A231GX63_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41189">
        <property type="protein sequence ID" value="OXR41189"/>
        <property type="gene ID" value="B7C42_06785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="875" mass="90363" checksum="4EAD05BAAE455C43" modified="2017-10-25" version="1">MNPERESPYWKAIVRDNWPEISPRTWGRLEALAREGAEALDPAEADRMRRAFDDRVRSSASLQPIKDELLAQQGTLRGFVDALVAAADTFGQMSSLVDRTRDRILNAVDGALRKISAARAAAAAAREKEEEAGGDGSEADARLRRDIRRILAEARAEVDDIAAAALREVGPQGLPELAAIAAALGQPGPWRGGPEGSDGPGGGPRYRSPRAGSDGPGGPGTHGVRSLPQGLRPSGGPFVPHLPSLQDLRDLLRPNESQLPLSRLPGWDIIAPDEVEPGIGHAPAPEDGTSAGPAVQVPPGSGPAPQAAPTGGGRSLGPMANPQADGGPPAAEVVAPEHRTVDAAPDQSDTVAAQHVSHTEIDSDDSRAGTADSGAERRTGESGAPDLTAGPGRRTDDTTGSENPPSWGVAAGMAAQMPMFAAQQPTFTPDRPPVVNSPAAAGAGADPRATSAPDSRNAIAAPRVTSAPGGSPGAVPGVSAPGVTAPPAAGPAKSQPPGRHTGEAGAGADKATGSEKSPDKDDTTGSGDLVRDAVGAAMAAAAAPTFMLGKRVDGDLVLARSLLASLLAAAGAPAVGTEWAVSIMRHDGGVSAFVTSNDGRGWLPPGVFLPRELSTPWVWSVAEGPAWEGLADPARVLAEFALSWGRRTGARLSALVSSAPFDELLARQLGEVALEGSVEPGPTMDFSTPAPGLADRLELVTAPPVLERVAAIPADRIGSRGLDFAYDAHQRLAVSGPDPFASLGAAELRHRIMQTILQGGPVQAQWWEQLFDADQLLAASMLPLLADVSRVPLGELRSEHSTGRSATDSATLRLSVAQRRCNEMVLLMSGEPSRQRLRDIVYAHGQVAEYLAAVPAGTITPEPVRRPTITAPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX89</accession>
    <name>A0A231GX89_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan endopeptidase RipA</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ripA_3</name>
        <name evidence="4" type="ORF">B7C42_06788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782281.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41192">
        <property type="protein sequence ID" value="OXR41192"/>
        <property type="gene ID" value="B7C42_06788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="197"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="33194" checksum="16E652CE5DE646CE" modified="2017-10-25" version="1">MSPQLTVGLDSVLNSLLKLYGTGSPAVQAAPSAAAPSNSAIDLRTGALMAGYHETAGMHASVAGAHAERDAVVHKAVTAAGDGTVKGRSVVNGQIADLQTRLRAIATVGDTRFSGPALLDAAHTAVTNAARQVDTDLAEAQRHAAQIVPPATPKTVRGRLTSNPGRRRRRRPRPRTTSVARTARALPAMHRPVPSDGTAGGKAVSAASAYLGLPYVWGGGGAGGPSGGGFDCSGLTQYAIAEATDGKVVLPRTTYEQIYSGVRIPPQDVRPGDLVFPAGSFSARGPEHVQLAAGNGMVIEAPYSGSTVKWSRMPSEAVVVRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXF0</accession>
    <name>A0A231GXF0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl-CoA hydratase echA8</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">echA8_9</name>
        <name evidence="2" type="ORF">B7C42_06711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41313">
        <property type="protein sequence ID" value="OXR41313"/>
        <property type="gene ID" value="B7C42_06711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="27308" checksum="2B4BD3C74C0B2EAA" modified="2017-10-25" version="1">MAERAQDVVTWETVEPGITAVTLRRPPANALGIPLLDGMHLAMDAAEKAGDVKVMVIGSALPGFFAAGADIKHLSTIDAETFTAYGDRMRAVNDRLAASPWLSIAAVDGVALGGGLELAMACTLRVAGPGGRFGLPEVKLGLIPGAGGTQRLPRLVGRGRALDIMLTARQVSAEEAYRIGLVDRLTDGDATEAALTFARELLGPSLPAQLSVVRTVDAAFDLSLAEGTRYEVEQIQALFEDGEAAEGISAFVGKRKPQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXI2</accession>
    <name>A0A231GXI2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folP2</name>
        <name evidence="3" type="ORF">B7C42_06470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41327">
        <property type="protein sequence ID" value="OXR41327"/>
        <property type="gene ID" value="B7C42_06470"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="30408" checksum="A99940A6579965AD" modified="2017-10-25" version="1">MSSASPLSTLCGKPVATDRALVMAIVNRTPDSFYDRGATFSDDAAMAAVARAVAEGADLVDIGGVKAGPGDEVDAAEEARRVVPFVAAIRARYPGLLISVDTWRSEVARAAVAEGADLINDTWAGADPQLAGVAAELGVGIVCSHTGGARPRTRPHRVRYADVVSEVTDTLVRAAEAARAAGVAADAILIDPTHDFGKNTYHGLELLRAVDILVNTGWPVLMALSNKDFIGETLGVGLSERLEGTLAATAWAAAAGARVFRVHEVAATRRVVDMIAAIQGIRPPARTLRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXL6</accession>
    <name>A0A231GXL6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan endopeptidase RipA</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ripA_2</name>
        <name evidence="4" type="ORF">B7C42_06659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41261">
        <property type="protein sequence ID" value="OXR41261"/>
        <property type="gene ID" value="B7C42_06659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="322"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="453" mass="46709" checksum="CAFFEE9C322AD52A" modified="2017-10-25" version="1">MSDPITVISTIVSAATGAVDNSGLPSPAANSAQAAVESAGEAAKSFTVQLDNAIARLPEPTQQTARQAVDDTSERVADMLPVKPPAAQSDTQDADVVPGTEPQLGRDSEATVQPAPQADVDSTPRYSTAPQSFAIVPVSPAAAVPAPVTGDIAVFVPWFRQAGALCSGIQAPTLAALYQAENGFRYGPSAPISPAGAMGPGQFMPATWAKYGRDVHGDGVPDVLDVGDSVMASGHLLCDTYQQIEGWKHVGVVSGDTLALTLAAYNAGAGAVLRSGGMPSGSPAYELETKPYVARILAARKQFEWLSADDYNLPAADHRPLEDLGRRIIAQAVKYLGLPYVWGGGGSNGPSSGGFDCSGLTSFAVHAATGGAVTLPRTSQNQWHVGTEIPLSQAVPGDLLFGNWGADGPGHVAIYLGNGRMVHAPTTGDVVRISPVMTGMRARHIGPDVSETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXV0</accession>
    <name>A0A231GXV0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41454">
        <property type="protein sequence ID" value="OXR41454"/>
        <property type="gene ID" value="B7C42_06345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="60" mass="6931" checksum="6A707FE730AD0EBE" modified="2017-10-25" version="1">MDVMPFRVYTTASGPDHEQSFPDPEDNFKFLEGGVLAVYTATKYTYYAPGFWTHLEEHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY45</accession>
    <name>A0A231GY45_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41495">
        <property type="protein sequence ID" value="OXR41495"/>
        <property type="gene ID" value="B7C42_06387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="37559" checksum="AF8F97A37487E1AA" modified="2017-10-25" version="1">MLTKMLGSRGLMSAAVVLVLVLTAGFGVKMTGSEPAMRSYCAEMPDSIGLYTDSAVTVMGVQVGKVTAIEPGNGAATVRFTVRADRTLPPDVGAVTVSHTILADRNLALIGAEPAGAGWDPGRCITKTLTPKSMSQTFDALAKLSDQLNAAADPAQRSAVGDGLDALERATSGTGAQLNALIEQLSRALASPDAAIGHLGQLMDDLAALAHRARNGWPELENIVPRLTETFSDINTLAFPPVADLVTALAGLLPELNEVVMKLGSPALRALNNVPGLSKLLASGVGSLAEIIRMTPALATGFTDAVDPVSGEFTIGYAPPKLALPPQQTDQICAALRAVAGQQCATAGNGAVTVPALPVLLSAVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYN0</accession>
    <name>A0A231GYN0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sad</name>
        <name evidence="6" type="ORF">B7C42_06076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41734">
        <property type="protein sequence ID" value="OXR41734"/>
        <property type="gene ID" value="B7C42_06076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009013">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="25"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="483" mass="51112" checksum="4F9D598F3458F24C" modified="2017-10-25" version="1">MVSQTELLESVPTQLWIGGPVDATGGATFAVENPATGEPLAHVADATPEDAVRALDAAVAAQDSWATTPARERGEILRAVYERIVERTEDFALLMTLEMGKALPESRNEVRYGAEFFRWFSEEAVRVHGRYQTAPTGTGRIVVHKQPVGPCLAITPWNFPLAMGTRKIGPALAAGCTMIVKPASATPLTMLLLAKLCSEAGLPDGVLSVITSSHSGAVTEPLINDPRLRKLTFTGSTGVGKKLVEKSANGLLRTSMELGGNAPFVVFDDADIDAAVQGAMLAKLRNGGEACTAANRFHVHNSVRAEFTDKLVAAMQEVKLGPGDDPSTTLGPLINQDQLDTVSELVEDAVERGAEVRIGGKAPGGTGYYYPATVLCEVPEQARILSEEVFGPVAPIVGFDTEEQGLAAANDTEFGLVAYVYTRDLDRALRIAEGLESGMVGINRGVISDPAAPFGGVKASGFGREGGFEGIEEYLSTKYIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYP5</accession>
    <name>A0A231GYP5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41719">
        <property type="protein sequence ID" value="OXR41719"/>
        <property type="gene ID" value="B7C42_06061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="32079" checksum="E7AD381733A719B2" modified="2017-10-25" version="1">MGEFVDDVVAIGPSAGRVSPGPVVFRIGVERPGSVGHSGQVQPHPHGPFAARRAEGLGVVARGIHEFDAQFANIGHVLDQVGGIPESREQLVQRLQNLLDRIDWDIGMIETGDHEIRMVETECFDQPGLGLRIGAQSGDVRRLLRRVRRMPLGSDQFGQHLLVRVGQHLPLRLGEVRQSIRDVRNLFSHRGDDRPRNRVVLPHRTTIDISNELGGERARHGLLGVECGPPACHLTVRADIPVLCAAPSPGDRVQQAEQLTGSRIQISTIHGAERRESFARRIIADQSQIVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYR2</accession>
    <name>A0A231GYR2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780858.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41730">
        <property type="protein sequence ID" value="OXR41730"/>
        <property type="gene ID" value="B7C42_06072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="20547" checksum="5CAEF5D9B1F090D3" modified="2017-10-25" version="1">MAYRRTPAVQARLDAQSRAIVHAAMKVLSEQGFGGLSMATVAAEAGVATGTVYKSFSGKAELVTAVFRDVVTREVAAVAQAGAEGGVVERVTAAVETFAGRALKNPKLAYVLLAEPVDASVDTERLRFRRAFAETFETAIADGVGAGQLPPQDPRTTATALVGAIGEVLVGPLAEQLQSESVVPELVAFALRALGAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYW0</accession>
    <name>A0A231GYW0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41778">
        <property type="protein sequence ID" value="OXR41778"/>
        <property type="gene ID" value="B7C42_06120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="41453" checksum="94960BC903A4B319" modified="2017-10-25" version="1">MAPVPLSTVDHMWTANMAGPLQFVVEFGEVLDADRIVEAYVETAREFVGADAALVQLDERTLALDVDDPRPAIRATVAESTVPLSECLDPVEIGVGHVLARGRVVTRGDRTAVGLSMSHGLADGYGMFFFLAAWAARARGARFLSPRCDREVLTRPQARERDSVDPDALRRAGFVTVEPDLELPELDVHTGRLDLTECEAQAEVSGLSTADLVAAGLFRDYAVTKDTDHVTLACPVDIRRFVRELGPTYFGNAFVQVLVDVETERVRNASVPEIAGWVRDAVASAPERIDDTIAELEAFLQVHGIAGLDRVWGYPPQSGFLVSNLSRIPASWLDFGAGPPVGLVTPGRRPRQDGAYLLPDPERAHSLQWASTLEHEPAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYW7</accession>
    <name>A0A231GYW7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">R2-like ligand binding oxidase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nrdB</name>
        <name evidence="2" type="ORF">B7C42_06117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41775">
        <property type="protein sequence ID" value="OXR41775"/>
        <property type="gene ID" value="B7C42_06117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="36057" checksum="A2D5F53E1592891B" modified="2017-10-25" version="1">MNNSTVIDEIEIDLAERVTALDLYRRWEMQQWQAQSLEYERDAEGWTQLPAFARLPLLATLARFLIGETTVTETLAPLAYAAPEVDYKMYLATQLADEARHTVFFRRYLAFLSDTLGNEELSQVSGVDRVGDLFEKALVDAVERVRADPADTAAWYEGVVVYHLLVEGAVAMTGLHTVLGTVRTLPGFDILRTGVTNVARDESRHISFGVLALRNGVRGGYRDHIVEMIRGHLPAAARTLVDPETRDPFPRLVPVLRKRAEILHEQWEFAESSLGRRMTSIGIPRDIISELAENWRESCAAAAGEYADIHGEPHPITYLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ62</accession>
    <name>A0A231GZ62_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-phenylpropionate/cinnamic acid dioxygenase subunit alpha</fullName>
            <ecNumber evidence="7">1.14.12.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hcaE_3</name>
        <name evidence="7" type="ORF">B7C42_05874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.19" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41890">
        <property type="protein sequence ID" value="OXR41890"/>
        <property type="gene ID" value="B7C42_05874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008695">
        <property type="term" value="F:3-phenylpropionate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="53"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="44453" checksum="C7BD7EEA7E2F6B26" modified="2017-10-25" version="1">MDRDEKISLTRRLIAHVDNNTTDYAEELLRVPFSVFDDPDLAVKERDVVRRFPHIVAHVDELAKAGDFLTTELIGTPLLVVRQNDGSVKAFANVCRHRGSRVEFAETGCKRVFACPYHNWSYGKDGSLRGMPHAEGFDGMDRAEYGLVEFPCEVRHGLVWVVPTAGAELNIAAILGDKHDAEVTDTGMGESFQVRKETWRLDMNWKIAVDGVQDSYHLCQLHTKTVCNYLEGNITAFDPVGRSWRLVVARKSITEVRDADPDSFDVRDYSLANYTIYPGTMLVTEPNHFEIWTIVPDAQDPNVSYCTIRLLSPGKPQTPREERILQKNWDLLMETLHAEDWFVTKTITANAAHGQVDELIYGRNELPGQVFHKMVADDVAALDTERPAAPVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZC5</accession>
    <name>A0A231GZC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actinorhodin polyketide synthase acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_05941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515841.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41957">
        <property type="protein sequence ID" value="OXR41957"/>
        <property type="gene ID" value="B7C42_05941"/>
    </dbReference>
    <dbReference type="GeneID" id="66724100"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="85" mass="9228" checksum="0839A4D0364293C4" modified="2017-10-25" version="1">MTITIDTLRRILVACAGGDEDAPELAGDIAEVEFEELGYDSLALIETASRIQREFGVTVPEEQLIDVKTPQELIDIVNQQLAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZN9</accession>
    <name>A0A231GZN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH-type transcriptional regulator HexR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hexR</name>
        <name evidence="4" type="ORF">B7C42_05668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42069">
        <property type="protein sequence ID" value="OXR42069"/>
        <property type="gene ID" value="B7C42_05668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="148"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="31718" checksum="BC3FC3C73492546B" modified="2017-10-25" version="1">MTQPAKSETSSAGPSNTESGNVIDAGGADPGARGATVSERIRARAGTLSPAGNRVAQILREQPATVLGMSVGELASQSDTSVGSVVRFSQELGFRGFQELKLQLAGDISTRPPARDKSIGLPGAIFLETAQALSQAVSALDTSVFHRAVTVLDGAHRVLVAGVGTSQPVAADAAYRLQLAGLMTASNPEVHSQHVSAALLGTGDACFTVSHSGQTQETLAITAAAREAGATTIGLTSFARTPLADVCDVVLVAGSAETDYRLEAMTSRFLHLAVVDALYVALSERNPERAEQAHARTLRVVARHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H095</accession>
    <name>A0A231H095_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42270">
        <property type="protein sequence ID" value="OXR42270"/>
        <property type="gene ID" value="B7C42_05469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007423">
        <property type="entry name" value="Sel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04328">
        <property type="entry name" value="Sel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="9782" checksum="F5B124E5087E039B" modified="2017-10-25" version="1">MADAAPAPSAVTEARTHRRAVAVLRAPLRAVRVGARYLNAVLGGQDYPRYVEHLRRRHPDRPIPSEREYWRERHAAADRNPGTRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B0</accession>
    <name>A0A231H0B0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42314">
        <property type="protein sequence ID" value="OXR42314"/>
        <property type="gene ID" value="B7C42_05513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="209"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="539" mass="60298" checksum="A3D507E06E2609BC" modified="2017-10-25" version="1">MQPDESVPAVDGAVLAKLDMEMRGVPENLPSPAELIASGAKCVLAYARISDLSGKRGTSKNAKGVTNQHTTNHSTARRENLVIVRYYTDNDLSASKDAYRPDFELMLTHLHKGVTPEGYPIHGVVAVDEDRIYKLPAQWQHFIEAFRAAPDRVFADDYGTQDLYSENSEIIGLLGVAIAMGENRKRRSRTRRWHEGQARRGIAHTGGRVFGYEPVEGKPGEIQVVPEEAALIRKAVTACIAGQSWGTITKLFQESGIPTAKGGPWRDQTVKQIVSNPRNAGLRILGEGNDVYRDEHGEMKLGQWEAIITPAEWEKVAERYRPRNRIGKNKLAKGVVSRVYLGSGLYRCGNLLEDGRRCNSVMAGRKNDKGRAAYRYGCRPVTNGGCGGVSVAGEWIDERISELVLLALDQRPAVVAEVHWDKESELEAAVRRRDDFEGRWNRGEIGDERFYRMLPGLDDTVNKLRRERAAFQRANTVPVETAVERRERWYKPVEDGGYDLQQKRSILFAELSAVVVYPVGRGTQKRSLDSFKPVWNAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0C6</accession>
    <name>A0A231H0C6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42310">
        <property type="protein sequence ID" value="OXR42310"/>
        <property type="gene ID" value="B7C42_05509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12883" checksum="65EECDD5615707FF" modified="2017-10-25" version="1">MFALWADPEYGRVPLGHHALTGTWWVTWRVISSVVDTVPIVTLVSMFESHPEPEETEMYGVMNHERVPVMTTGFAHIIMQVHIDCALCVCPVKQQAKQRLIEAKRLVPDSTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0C8</accession>
    <name>A0A231H0C8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42309">
        <property type="protein sequence ID" value="OXR42309"/>
        <property type="gene ID" value="B7C42_05508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="182" mass="20579" checksum="F715988FC939660F" modified="2017-10-25" version="1">MAGFSRTNLGRQRTEWDLRDGQVTVLGFVDGERDGIDMTRFGEVTALWCEPGGVAFPGGLLLGHVRAMLPEYHSLWCAVSEQARVLALDQFTPHVTRVLRAMADGSEWWSERLCQEHEFSRRGSTRSLNWLCRHGYIEGAGRAVDTGRYDHEPVYRITEAGRCIFRMLSESPAEFRALATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H108</accession>
    <name>A0A231H108_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42554">
        <property type="protein sequence ID" value="OXR42554"/>
        <property type="gene ID" value="B7C42_05331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="61" mass="6717" checksum="13064F8E415B89CF" modified="2017-10-25" version="1">MSLSAAPQLRQSDVIRRFCEDCLAPIDSLEEARRVLTFHAGHGARCPQYLAALSWASEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H191</accession>
    <name>A0A231H191_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_7</name>
        <name evidence="4" type="ORF">B7C42_05358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777362.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42581">
        <property type="protein sequence ID" value="OXR42581"/>
        <property type="gene ID" value="B7C42_05358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="454" mass="50158" checksum="DE668DC7B9389BA2" modified="2017-10-25" version="1">MPKQQVRKQIHLAAHFPGVNNTTVWSVPESGSQIEFDSFVHLARTAERGLFDFFFLAEGLRLREHRGRIFDLDVVGRPDTFTVLDALAGVTTHLGLAGTINTTFNEPFELARQFASLDHLSGGRAAWNAVTSSDAFTGENFRRGGYLDHSQRYVRAAEVVDATRAIWDSRAGGAPVVDRERGVFGGPAPRFSYRGTQFDIEGVYGLPASPQGYPVQIQAGDSEEGREFAAAKADAIFSRHGELEDGRQFYTDIKTRLAKYGRRRDDLKILPAATFVLGDSDADAQERAREIRLQQVGPQTAIAFLEQVWGRDLSGYDPDGPLPEIDPVDNANITRGRVRHAKDPRAIAEAWRAKAEAEKLSIRELIIEVTARQQFVGTPAQVAAEIDRYVQSDAADGFVLVPHLTPAGLDEFVDKVVPELQDLGSFRTEYTGVTLREHLGLRHPHRGSEGVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1C4</accession>
    <name>A0A231H1C4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42655">
        <property type="protein sequence ID" value="OXR42655"/>
        <property type="gene ID" value="B7C42_05433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021941">
        <property type="entry name" value="DUF3556_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12077">
        <property type="entry name" value="DUF3556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="580" mass="64078" checksum="0989F18DC639AC3E" modified="2017-10-25" version="1">MGFVQPELPVVDQQQWDNSDRSERIRLMARHWAEVGFGTPVVLHLFYVVKICLYILGGWLFALSTSGIDGFTDVGSWWSEPIVFEKVVLYTMLFEVIGLGCGFGPLNNRYFPPMGSILYWLRPGTIRLPPWPRVVPLTRGTARTPVDAALYALLLALLLWALLSDGTGPIPALDITVGLLPAWHVGLVVAVLAVLGLRDKVIFLAARGEVYGSLAVAFLFGGADAILAAKLVFVVIWMGAATSKLNRHFPFVVSTMMSNSPIVRPRWLKRRFFADFPDDLRPGRLSRWVAHSGTAVEMCAPIVLFFSHGGRPTAVAAVILLCFHLVILTAIPMGVPLEWNVFMIFGLGVLFVAHADIGFAAAEHPWLPVLLFAVLVAIVITGNLLPSRISFLPGMRYYAGNWDTTVWCVKPSAAQKIDRNIVAIASMPQAQMERYYGKDRAQIPLYLGYAFRAMNTHGRALFTLVHRAMPTGREDEYTITDGERICSTAIGWNFGDGHMHNEQLIAALQQRCHFEPGEVRIVLLDAQPIHTQVQAYRLVDAATGEFERGTVRVADMVESQPWADNLPVHVTSTAGPTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1G6</accession>
    <name>A0A231H1G6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine/hypoxanthine permease PbuG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pbuG</name>
        <name evidence="8" type="ORF">B7C42_05026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776833.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42690">
        <property type="protein sequence ID" value="OXR42690"/>
        <property type="gene ID" value="B7C42_05026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="454" mass="47419" checksum="37D162C389EA4CEC" modified="2017-10-25" version="1">MSSVDVLSRSKGRLDSYFGIARLGSTMRRELMAGTVTFLAMSYVLAVNPAVLGDHGQLGSRGIPTQAVFTATAVAAVVGTLVMGVWARYPIALAPGMGLNAFFAYSVVLGMGIDWQVALSGTLLSGIIFFILAVTKIREKIIDAIPLQLKLAVGAGIGMFVAFLGLKNAGIVVSDPATFVHLGDFTKGTTLLALFGLLVTVVFLVLGWHGAVLYGIVSTTVVGIVSGLVHLPHQVVALPHGLDQTFGQAIVNLPHAFTGQMAIVVLTMLFVDFFDASGTLIGIANQAGLLGPDGKLPRAAQALAADSIGTAAGAIIGTSTTTAYVESTAGVSAGGRTGLTAVSTAGWFLAAMFFFPIFAVVADVPAVTAPALIVVGVLMSRALGDIDWGKLEYAIPAFITVIMMPLTYSIANGIAMGLTFYPVVMVARRRGREVHPVMWVLMAVFLAYFFFLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1J7</accession>
    <name>A0A231H1J7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein LppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lppC_1</name>
        <name evidence="2" type="ORF">B7C42_05057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776855.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42720">
        <property type="protein sequence ID" value="OXR42720"/>
        <property type="gene ID" value="B7C42_05057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="20170" checksum="9966C0480DF24209" modified="2017-10-25" version="1">MSILGKLLAHRRAGESELAWNQPNLLGDTVFRLTSPDFEPEATLDIRHASHRIGGADESPALSWSGAPDASAGYLLVVEDPDAPMRKPFVHCVALLDPSVRSLSRNALRADTDEAGVRILRSGFGRGYLGPAPIKGHGPHRYVFELFALGAPLTTAAGKPLESAKPREVLAAAQAVGRARIDGFYERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H208</accession>
    <name>A0A231H208_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MaoC_dehydrat_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780158.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42883">
        <property type="protein sequence ID" value="OXR42883"/>
        <property type="gene ID" value="B7C42_05221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="35163" checksum="169F85EB5276F581" modified="2017-10-25" version="1">MVSASLDVPPVASPHGEHRFRTRGEGPIAAETIREYARAIGATDPIHRDERAAAARGFDALVAPPTFATTVWMRAEERTLDALVPGFHSGSVVHADRTLEIVRPLLAGDRISCDIGFESFRHYRDYDVVSVTTLLRDDDGQVVTSGSSTLLVHTQPGTCARSGTPQRPHDLEPVPAQRRLRTPQRDRIQPPLPRPIVDLGPLAVGADLPVDTVTVAADDVVRHADVVDPQRSGTTTGAVPGMLTLGLVAGYLGRWLGDPTALTKLRVQYAPKMHYLPVDSDAPASILFGGQVGWLSSRRRMVTVVVDALSKGRKLFGYATAEARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H214</accession>
    <name>A0A231H214_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0310 protein B7C42_05210</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0310 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42872">
        <property type="protein sequence ID" value="OXR42872"/>
        <property type="gene ID" value="B7C42_05210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00771">
        <property type="entry name" value="UPF0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022996">
        <property type="entry name" value="UPF0310"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="2">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16483" checksum="FFEA30A55325E0C8" modified="2017-10-25" version="1">MNKYWLAVVSRDHVRRGVALGIVQANHGKRAAVERMRAGDGLVYYSPRTGMREGEPVKSFTAIGTVDDRPAWQAEDPGGCFRPWRRAVTYRPDAHDVAIDAVRGDLDLTSVPNWGIVLRRGVVELSAHDFAVISRAMLGENAGERSGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2N6</accession>
    <name>A0A231H2N6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43111">
        <property type="protein sequence ID" value="OXR43111"/>
        <property type="gene ID" value="B7C42_04997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="163"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="388" mass="43868" checksum="EBBB5EABE460A0D8" modified="2017-10-25" version="1">MSYVVRWVDPDGVERSESFAKRGRYDQPGTAEYYKHQLETRMARGMYVDPDLAKVLLKVEVDKWIRRARTETTRYQRQNFANNLGDLASMAIGAIRPSDIRDWLDHLRLGRPWCQGRALGENSVALQFQFLFTVLNIAAEDGVIVANPCRKVERPSRPDAEKSPAELLTVEQIRSLIRHSNRQTGCMMLLTAQTGLRPSEVAGLRVCDVDFLRRKIFVVQQANHFRGKAPTARLKTPRSKRTVPLPAEAHRELSAFLATVERGRSDLLFYTKAGRPWSADGMGQRFREIAAKAGAPRGFTWHDLRHFYASALIAKGASVKTVQARLGHASANVTLQVYTHLWPDHDSHTISAIDDIFHPNRDNPRGVPENSEVDFDDRREEDGSATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2U4</accession>
    <name>A0A231H2U4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_16</name>
        <name evidence="3" type="ORF">B7C42_04605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43183">
        <property type="protein sequence ID" value="OXR43183"/>
        <property type="gene ID" value="B7C42_04605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="420"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="514" mass="56419" checksum="8C53C3B141229575" modified="2017-10-25" version="1">MYPAHFAASTPDKPAVIDTATGAVQTYGDLVAGANRLARLLREAGLRPGDHYVILAENHLRYFELVWAGMNSGLYVTPVNSHLTAAEVAYLINDSTAKVVITTAALASVAEQIVDLTPDVVRRFMLDGTSTSYESLDDAAARYSGGPDDQEVRGTFMLYSSGTTGRPKGIRYPLPDHPAADGDAELLPSGRALFGLDADTVFLSPAPLYHAAPLRVSCLVHCSGGTVAIMPKFDAEAALRAIDEYSVTSSQWVPTMFVRMLKLAPRIRSRFDLSSMRVAVHAAAPCPIEVKKQMIDWWGPIITEYYSGTENFGTTALSSEQWLDHPGSVGRPVGCTVHICDDNGDELSYDDIGTVYFETAGANFSYHRDPERTAAVSHPEHPDWHTLGDIGQLDADGYLYLTDRRDFTIIAGGVNIYPREIEDVLILHPQVADVAVFGVPDPELGEQVKAVVQPADWADAGPELTQRLLDHCRGRLASYKWPRSIDFARELPRQDNGKLYKKLLRDPYWAQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Z8</accession>
    <name>A0A231H2Z8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acoA_2</name>
        <name evidence="4" type="ORF">B7C42_04600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43178">
        <property type="protein sequence ID" value="OXR43178"/>
        <property type="gene ID" value="B7C42_04600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="36"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="34667" checksum="209114A3405255ED" modified="2017-10-25" version="1">MSPSTPAPSPEAQLDIFATATRIALSDEKYRSYMLSGKIGGMYYSPRGQEFVAASVAAHLRRDDYVVTTYRGLHDQVAKGVPLRDLWAEYLGKAAGTCGGKGGPMHVTAPEYGLMVTTGVVGAGLPIANGLGLSAQMRGTDQVTVVNFGDGASNIGAFHEALNLASVWRLPVVFVCQNNRYAEYTPLREGTSVESIATRAAGYSMPGVTVDGNDPIAMYQVAGDAIGRARRGEGPTLLEAMTFRFHGHVMGDQQGYMPKEELAAAMANDPLPRFRAQLIESGAATVEQIEAVEAAAAAEVADAAEFAFDAPLPDPAELTTDVYAEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H318</accession>
    <name>A0A231H318_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009641.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43244">
        <property type="protein sequence ID" value="OXR43244"/>
        <property type="gene ID" value="B7C42_04666"/>
    </dbReference>
    <dbReference type="GeneID" id="66723450"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="20707" checksum="FE1335A52A27F869" modified="2017-10-25" version="1">MTIDVDAANKVLGGLRPFPVAVTTIDGGFANGLMSLSAGSMSIVPELPRATVSLTKYNKTHDMVLSSGIFVMHLLSAVPEQLDASLDILMTLGGSSGRDGDKISKLRTKTGVTGAPILLDAHSYVETRVMATLDVEESTIFVGDVVAAEILNPGERLRIGEAWGKLPAEWIERYETNHVPQLESARAYRAAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H398</accession>
    <name>A0A231H398_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_04704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064908346.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43282">
        <property type="protein sequence ID" value="OXR43282"/>
        <property type="gene ID" value="B7C42_04704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="27231" checksum="8B1B9536E7AEFDF2" modified="2017-10-25" version="1">MARTAAGSGAGRPRSPRGQGEELRTEILAAVNRLLAEWGGVDKLTMRAVANEVGTTAGSIYLHFTDKTELVWAALSDKYAELAARMAEADAGAVPDGARERLRAQTHAYCRFGLEHPGHYRLMYEVRQPEVDVARISRHPSRLISESLRQGFIRCREAGFGLALPIEQSAQTLWQALHGELSLAHSIFFDSSTEALVLELADGMLDALVSAAPDDDRRWPSPTDSPAARHIRSMLKRDDAPAMERDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3P8</accession>
    <name>A0A231H3P8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA pyrophosphohydrolase</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rppH_1</name>
        <name evidence="5" type="ORF">B7C42_04328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43461">
        <property type="protein sequence ID" value="OXR43461"/>
        <property type="gene ID" value="B7C42_04328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="186"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="348" mass="38369" checksum="E4F03A104C0665A9" modified="2017-10-25" version="1">MITFSATTILVLALIAAVIIAIGVWAYSTANRLDRLHVRGDQARDALEAALARRAVVARTVAISMAGPMSESAAAEQSKRLIALADRAERAGWSDRETAENQLAAALSAVDITSLRPQLVAELADAEARVLIARRFHNDAVRDTLALRTRRPVRLLHLGGTAPLPTYFEIAERVTPAATTGLEVDTVRTSARVVLLDDEDRVLLVRGHDPQTPDSPFWFTVGGGIEPGETLRTAAVREVWEETGLALDSTLLRGPIWRRVAVFPFNGELIRSEELFFVARVRWFDPKPADPTVWERRCVTAYRWCLPPDIAELDRIGETVYPYHLDNLLAEALAAAGSDIEPEVRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H422</accession>
    <name>A0A231H422_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ORF">B7C42_04517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778873.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43649">
        <property type="protein sequence ID" value="OXR43649"/>
        <property type="gene ID" value="B7C42_04517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="34969" checksum="F0706A2B5DF7357B" modified="2017-10-25" version="1">MRSIWKGSIAFGLVNVPVKVYTATEDHDIRFHQVHAKDGGRIKYDRVCTVCGQSVAFADIDKAYESPEGDKVILTDEDFAKLPVAEKHEIPVLQFVPSEQIDPILFDRSYYLEPDSTTPKAYVLLAKTLDQVDRVALVHFTLRQKTRLAALRVRDGVLVLQTLLWPDEVRAAEFESLDDAAAPRSQEVAMAQTLVDSMSEDFDPDQYTDEYQIELKKLLDEAIESGSDRVTRHEEAEPAQMDAEVVDLVAALQRSLEATGRGGESGKSGRGRASKSAAKSTAKATTKRAASKSTGTKSASKSTAKKAAPKAAKQTRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4A8</accession>
    <name>A0A231H4A8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43668">
        <property type="protein sequence ID" value="OXR43668"/>
        <property type="gene ID" value="B7C42_04536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="598" mass="60758" checksum="20E5D9BC00E813BA" modified="2017-10-25" version="1">MVVTVPVVSLALYMWAGWDPTRSLDRLPVALVNLDQPAQQGSTTLTVGNDVTTSLLSSRALDFHTVDHDAAMTGLASGRCYFVIEIPADFSRTLATLGTTSMAPALISVVYNDRTTLMASNIGARAMSVIDAAVLEGVSSKTVGTLLSGLDGLGGGIRSAAQGSDQLHNGLTELATGTDTLVSGIREQLAPGVSAAAAGGAQLSAGTTALATGLTGLQTGTGQLGDGAQNVASGIDQLLGAVDAAQLGKTLGDLAGQLPPGTLDHIVQLLDGLRQLQAGSHQVADQLTDPHAAYRSGVDQLVIGGGQVDAGAAKLAAGLRDLDTGTGQLADGASRLQQGVHAADSGSGQLADGLAVGAQQVPDLSDANHRDNLAHLLSTPVNSRAHNLAPAQFGGPGAAPMLLILITALVPIVVLMCLRAHRFVAADEPLPPLGVAVRRTVAAGACSLAVVGLLGVVVWHVLSPSPTVSSMAHLIIAISVATIMNTALTSLLFTTLGYAAGALGSLAALMLQVFSYGGIWMVQTLPAPLRWLHSIAPMTYTQRALVASFDSTPGFFVSVLVIIAVTAIAGTANVLLYRSGRARWPHAVSKPVALAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4G9</accession>
    <name>A0A231H4G9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine protease HhoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hhoB_1</name>
        <name evidence="3" type="ORF">B7C42_03963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43728">
        <property type="protein sequence ID" value="OXR43728"/>
        <property type="gene ID" value="B7C42_03963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="283"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="370" mass="36942" checksum="E47878D4E1E9F13E" modified="2017-10-25" version="1">MDEQHSGRRSRPARGGWLSTVVFVLVMALVGAAFLGYRGDLPRWAVPAGHSTSALFGPPVPPMDPAAVASAVEPELVNINVSIRPSGMGAAGSGIVLSPDGEILTSHHVVKGAETITVGDLGNGGHYPATVLGYDSDADIALLSLTGAAALSVARIGSSAGVRVGDQALAIGNAGGTGSPTATPGTVTALDASIVARDAADLSRKALIGMIEVAAPVVSGQSGGALVDRSGAVIGVVTAASGELSRQQGQASGYAVPIDRALSVVRQIRTGIPTDTVHVGPTATLGVLTSDAKPTGARVDVAIYGLPAFAAGLNSGEVIVAVDDTPVTSAQSLKAALNVRRPDEVIRLDLVEPDGTHRALAVTLAAGPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H516</accession>
    <name>A0A231H516_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780961.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43954">
        <property type="protein sequence ID" value="OXR43954"/>
        <property type="gene ID" value="B7C42_04193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="25991" checksum="BB7C7022F70241D8" modified="2017-10-25" version="1">MTTTLTVSDLTLTFPDGAGHVTALDRVALTVRGGEIAAITGPSGSGKSSLLATVSTLVRPDAGRILLDTDDGGVDLARVSRREATTLRRERIGIVFQQPNLIPALTAVEQLEVMRHLGGHTVVAPRLRRRTRDKAMDLLDAVGLRGHEKKRPAQLSGGQRQRVDIARALMHDPALLVVDEPTSALDQERGAAVIDLILGVVHTHAAATLLVTHDRTHLHRMNAVYRMVDGRLSMAESGELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H560</accession>
    <name>A0A231H560_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43967">
        <property type="protein sequence ID" value="OXR43967"/>
        <property type="gene ID" value="B7C42_04206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="178"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="371" mass="39425" checksum="F63B6584C98A689E" modified="2017-10-25" version="1">MTSTWLAGFRSAIISPYEQFQLTEPRGFTDRTVRQVLHMAGGGRQLRVRLSNRYGRDALEIGAARIALRKNGFTAVAETDTVLRFDGADRVRIPAGGEIVSDAVDLAVHGGDDLLLSLYLPGPTGLATFSHQPMEITAVVAGDHTADPDPSEVEEVASRFFVTGVDVLADADTPVLVAFGDSWFDGAGTTLGANRRSVDALNSLLTRGWVVNQGIGGNQLLTDEVGEHALARFDRDVLAVPGVTHVVVNLGINDLGLGEVAAAGDLIAGYTELAARAHAAGLPIYANTIGPFAGVIYPEVNVDPALPVRVVVNEWLRSTTVFDAVFDVAAAVAEPERPDFIRPDLDSGDGLHLNDEGARVMAETMRIPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H628</accession>
    <name>A0A231H628_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inner membrane protein YphA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yphA</name>
        <name evidence="6" type="ORF">B7C42_03818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777582.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44257">
        <property type="protein sequence ID" value="OXR44257"/>
        <property type="gene ID" value="B7C42_03818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="14553" checksum="1E34F9DDA711571D" modified="2017-10-25" version="1">MSVLVLIGRILFVILFASSAIGHLTQADAMTGYARSKGVPMAKEAVLGSGVVLLLGALSVLLGVWADLGALLLFVFLLPTAFLMHPFWKESDAQAKQGEMIHFNKDLALAGAALMLFAFFAHVDDLGATITGPLFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H676</accession>
    <name>A0A231H676_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 17" type="primary">hisD</name>
        <name evidence="17" type="ORF">B7C42_03766</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44206">
        <property type="protein sequence ID" value="OXR44206"/>
        <property type="gene ID" value="B7C42_03766"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR44206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="445" mass="45968" checksum="BD85DE5A03036D89" modified="2017-10-25" version="1">MTSRIELARVDLRGRTPSAAELRAALPRGGVDVDSVLHHVRPVVEAIRDRGVEAAQEFSAKFDGITPASVRVPAAELDKALAELAPAVRAALEVAIERTRKVHADQRRTDTTTEVVPGGTVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQAQFGGLPHPTILAAAKLLGVEEVWAVGGAQAVALLSYGGTDTDGAQLAPVDMITGPGNIYVTAAKRLCRGLVGIDAEAGPTEIAILADATADPAHVAADLISQAEHDVLAASVLVTDSVALADAVDAAITTQLEVVKHRERVSEALSGKQSGVVLVDDIEQGLRVVNAYAAEHLEIQTADAAAVAGRVRSAGAVFVGAWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYSEAALKDVAGHVVSLANAEDLPAHGQAVQVRFEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6X2</accession>
    <name>A0A231H6X2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-alanine aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dat</name>
        <name evidence="1" type="ORF">B7C42_03388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.21" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44598">
        <property type="protein sequence ID" value="OXR44598"/>
        <property type="gene ID" value="B7C42_03388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047810">
        <property type="term" value="F:D-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="304" mass="32765" checksum="DF468681D4B4BEA4" modified="2017-10-25" version="1">MVDRVLVTLDGTVRNPDEPLLYADDIGALRGDGVFETVLVRDGKASALELHLARLRRSAQALDLPDPDVAQWRTAVEAAVKEWGSDREGVLRMIVTRGRDGADSRRVGSGELSGPAPDLTGYVLVSAVAERVSKARAEGISVITLTRGISTELATTAPWLLLGAKTLSYATNMAALRFAARQDADDVIFTSTEHRVLEGPRSTVVIQRDKQLLTPPARDGVLPGITQRALFAEAGKAGWDCSYKSLFTADLVTADSVWLLSSITLAARVTTLDGLRMSAPDCAEEIADLVNRGIERAWNIADWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H795</accession>
    <name>A0A231H795_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pepN_2</name>
        <name evidence="14" type="ORF">B7C42_03444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44650">
        <property type="protein sequence ID" value="OXR44650"/>
        <property type="gene ID" value="B7C42_03444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011288744" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="34"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="62"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="316"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR44650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="476" mass="51980" checksum="F7B0DEC3631A034C" modified="2017-10-25" version="1">MESHAWARCLTAGALCGVALVLPAYVQPVPAQAQPAADPFTGSPGLGDPYYPDDGNGGYDVQHYDVAIDYDPPTRHLTGTARIDAVSTQPLRAFNLDYAGPAVVKVSVNNLPAGFTTGGAHELTVTPALPVLPGLPFTVTVDYAGAESDDPDSGWTISPSGGAFAAGEPHSATTWYPLNDTPVDKATFDLQVTIPQEWQAVSNGLRVSDTVAGDKRTVTWSSSHPSIGYLTTVAIDHFDFLEQRRANGTPLISAFAPGADKGRALEQRLPEVLDFLESLYGPYPFESGGGIYVDTDLHFSLETQTRPIYAPWTDLDTVVHENTHQWWGDSMSVRNWSDICLNECFASYTADYLWPERKEGKDVDTLYRRTIAKTIDNPGYWEIPLQNPGAGNEFTTVYSRGPLFLHALRHELGDEVFFPAVAQFVRSHAYGNASMPEFRSFIQTKTATDLSGFFTAWLDTTTPPPDQYLYPGSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7B5</accession>
    <name>A0A231H7B5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776302.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44738">
        <property type="protein sequence ID" value="OXR44738"/>
        <property type="gene ID" value="B7C42_03533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17090" checksum="2672009E9FE507BD" modified="2017-10-25" version="1">MSETSSAETNDDTPAFADVVNGALEFTIPIAHKMGVQALEVRPGFAATTVPIEGNGNHFGVMYAGVLFTVAEILGGAIPIATFDSAKYYPLVKDLQIFFRKPAKTDVRAQASLSEEEIARVIADAEANGKADFTLEATVTDADGVVVAETRGLYQLRAHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7U5</accession>
    <name>A0A231H7U5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784190.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44929">
        <property type="protein sequence ID" value="OXR44929"/>
        <property type="gene ID" value="B7C42_02885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16297" checksum="C35B621B5E993099" modified="2017-10-25" version="1">MTAIYASEQVTEQPTACIAPVQSRYREIFGDTWYEERIGALVLRSGRLCAVMTPAGLGTSVLGMLGDLQVPVMAVGVGNRCVWSFLAENPSCGEGAGWWSLDLFRCFVTQTRPGALIALPTPGNPRRTWVREPQDTVPDLRLVAETIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7V1</accession>
    <name>A0A231H7V1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44915">
        <property type="protein sequence ID" value="OXR44915"/>
        <property type="gene ID" value="B7C42_02871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="489"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="545" mass="59129" checksum="4EA1CDB49B9B31A4" modified="2017-10-25" version="1">MTTMRPTVDGDATPVPTSLLSVLVSWRSTALLDAHAVLLTAGGRVRSARDVVYFNAPRHPSQAVTVDQDPQPGTARLSVSLPRTEAEIVRILITGSGPDQPLTALPGLAVAVEDAEGLVARADVAAEPGARAAVFAEFRRAEDRWWFVRGGPQHADAAELFTTFGAPVADSAQHRSQRLSLRRTRFAAPMPPPRDARPDWHPDPADAASLRWWDGSRWTEQTLPGPPTDPRGCPRCGRRRGWRLLGAAPCRTCAAEVEDYLSEWRMRALRVLTTTGPSGPDWDELWTRIRHRRIDPDTARAALRGPAVAHLERTAAFALADGTITGAALERFDATVAALGVRDGAVEELRRSLRRLRILSRLRAGELPVIAVPDLHLDPQERVHLDTAATRIRRTGRGAHASPGRLICSNRKLRFIGPDAGIEIPWARAVSVSATETGVTVAATSARGGAEFDVEEPELVAAIVEGALRVAKRLTVAPGRRDSRSIAPDIKAEVWHRDGGRCVECGATHYLEFDHIIPLSRGGATSAANLQILCRGCNRDKGDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8B3</accession>
    <name>A0A231H8B3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44987">
        <property type="protein sequence ID" value="OXR44987"/>
        <property type="gene ID" value="B7C42_02944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="5126" checksum="FBAEC6F89C078659" modified="2017-10-25" version="1">MLTCLDPRQRGPKGSCPAMRTTDVDRLAGGVRRTVAVATPGLRAEGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8D7</accession>
    <name>A0A231H8D7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45098">
        <property type="protein sequence ID" value="OXR45098"/>
        <property type="gene ID" value="B7C42_03055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="248"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="606" mass="65988" checksum="B16220A22A0B7457" modified="2017-10-25" version="1">MSWYVPIMIANSAAAPHVLREYSFIADGERGALVGPRGDISWMCLPRWDGDAVFASLLGGSGLYAVTPSGPFVWGGYYEDGTLIWRSRWLSGSAVIECREALAFPGDRHRAVLMRRVVAVQEDAEIDVELRPVARFGAAPIHHPRRADGVWTARAGGLRMRWSGAPGAEIDEDGSGRGWTAHLSVPAGSYHDLILEMSDRTLPDDLPDPDTYWEATENAWRRDRPDFGATAAPRDSAHAFAVLRGMTADTGGMVAAPTTSLPERADRGENYDYRYVWIRDQCLAGQAIAIGGPHPLLDAAVGFTAARLLDDGPTLAPAYTIDGKSVPPVREIELPGYPGARPVIGNRVRGQFQLDTFGEALLLFAAAARHDRLGGDHRRAVDIAVSAIADNHHRPDAGIWEIENRLWTHSRLICAAGLRAVAACPDTGADIAYCSSLADTLVAEAARTGVHPTGRWQRAPDQPGVDAALLLPLIRGALPADDPRYAATFFAIQRDLTTDYCVYRYRHDDRPLEMSEGAFLLCGFTMAMAAAQLDRPVTAMRFFERNRASCGTPGLFAEEFDVRQRQLRGNLPQAFVHAMLLEASLRLGPLAPELPSEAVVPTDRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H935</accession>
    <name>A0A231H935_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45368">
        <property type="protein sequence ID" value="OXR45368"/>
        <property type="gene ID" value="B7C42_02493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036435">
        <property type="entry name" value="Leukocidin/porin_MspA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015286">
        <property type="entry name" value="Porin_fam_mycobact-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09203">
        <property type="entry name" value="MspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56959">
        <property type="entry name" value="SSF56959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257587" evidence="2">
        <location>
            <begin position="27"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="21032" checksum="0AF24C7D8CA563DD" modified="2017-10-25" version="1">MSITSVYAAATTALALALLPATAASAAGPGGHENTYLAPNGYSFTVGHLDYAAHPVTALNGMPTNREVFLDNTSYARIPSGTATLKAGYFVACAVDIDLGFSADASASLSAGATISPDLVDPSASVTIGPSVSAGIGVNVSVAPGKITDVEVGRKHLGAGETDYLVSRDFHLMVQGCGGPLTIRAYSRIEVSAAEVDGNGAVFADPTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H942</accession>
    <name>A0A231H942_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45369">
        <property type="protein sequence ID" value="OXR45369"/>
        <property type="gene ID" value="B7C42_02494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036435">
        <property type="entry name" value="Leukocidin/porin_MspA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015286">
        <property type="entry name" value="Porin_fam_mycobact-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09203">
        <property type="entry name" value="MspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56959">
        <property type="entry name" value="SSF56959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280104" evidence="2">
        <location>
            <begin position="37"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="23107" checksum="29D744C4865F3CDC" modified="2017-10-25" version="1">MLASRLPIRGVHVRKWVMVAVTTIGGCTVAATPAMGASAAHERTYSVPEFTYTVGNSDQQAAPIPPLNGMPTNREVLVGGTFYGRVAAPATGKLHAGYLVACAAEMDASLAIQAGLSGFSELSGNLYVAPSQVSPGLYWDVVDGTVSGSATVNTTLKPGKVTDVKVADKDLKADTTGTLYSRDFRIEVDNCVGPLAVQPYTSINADTPGDSGTGMILGDPIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H943</accession>
    <name>A0A231H943_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">icd</name>
        <name evidence="14" type="ORF">B7C42_02476</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513542.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45351">
        <property type="protein sequence ID" value="OXR45351"/>
        <property type="gene ID" value="B7C42_02476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="13">
        <location>
            <begin position="9"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="310"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR45351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="45028" checksum="D7FADA6076153769" modified="2017-10-25" version="1">MSKIKVEGTVVELDGDEMTRIIWQFIKDKLIHPYLDVNLEYYDLGIETRDKTDDQVTVDAANAIKKHGVGVKCATITPDEARVEEFGLKKMWRSPNGTIRNILGGTIFRAPIIISNVPRLVPGWTKPIIIGRHAFGDQYRATDFKVHQAGTVTIQFTPEDGSEPIVHEVVKMPEDGGVVMGMYNFKKSIEDFARASLNYGLQQNYPVYMSTKNTILKAYDGMFKDTFQEIFETEFKDEFAAAGLTYEHRLIDDMVASALKWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLTPDGRTCEAEAAHGTVTRHFRQHQQGKPTSTNPIASIFAWTRGLAHRGKLDNTPEVIGFAQTLEDVVIKTVESGQMTKDLALLVGGNQGYLTTEEFLGVLDANLARELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H962</accession>
    <name>A0A231H962_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-ketoadipyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.174</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pcaF_3</name>
        <name evidence="6" type="ORF">B7C42_02467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45342">
        <property type="protein sequence ID" value="OXR45342"/>
        <property type="gene ID" value="B7C42_02467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="279"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="43581" checksum="CAA113861B79CE4C" modified="2017-10-25" version="1">MANKVYVVGVGMTKFEKPGRRQVEEADGTTRAWDYPDMARESGTKALADAGIDYRQVQQAYVGYVYGESTSGQRAVYELGMTGIPVINVNNNCSTGSTALYLAAQAIRGGLADCTLALGFEKMQPGSLGSTWDDREQPMAKHMMALAEISEVLFPPAPWMFGAAGREHMKQYGTTAEHFAKIGYKNHKHSVNNPYSQFQDEYSLDDILGARMIYDPLTKLQCSPTSDGSGAVVLASEDFVDRHGLAGRAVEIVGQAMTTDFASTFDGTAKNLIGYDMNVQAAQQVYRQSGLGPQDFQVIELHDCFSANELLLYEALGLCGEGEAGSLIDGDQTTYGGKWVVNPSGGLISKGHPLGATGLAQCSELTWQLRGDADKRQVEGVTAALQHNIGLGGAAVVTAYQRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9A8</accession>
    <name>A0A231H9A8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513482.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45411">
        <property type="protein sequence ID" value="OXR45411"/>
        <property type="gene ID" value="B7C42_02536"/>
    </dbReference>
    <dbReference type="GeneID" id="66719047"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="102" mass="11244" checksum="D0046EBBBF2D2151" modified="2017-10-25" version="1">MIHSGDLPGLDLPEVDAHSDLGGIGAVELNHPSQDIDADGILDTETFHSDHSMEVWSDMDHDGYADHVSIVDDGGDYSAWEFHHYPDGRTEWVQVDKGKMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9W1</accession>
    <name>A0A231H9W1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45592">
        <property type="protein sequence ID" value="OXR45592"/>
        <property type="gene ID" value="B7C42_01884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="15013" checksum="A92672CDBC08D5E9" modified="2017-10-25" version="1">MNRQSSRIDTRDNHDGPFRTHAVRPGTAGPELRLVLARSARSQLEFLAARRTIDAETVPMIEFAIRWAPFGGANPGDLLVTFGIDRRRFMTLIEEGLWFRRTDDSEERRLEQRLSDALTSAWCAQDDGPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAL0</accession>
    <name>A0A231HAL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase EphD</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ephD_1</name>
        <name evidence="2" type="ORF">B7C42_02180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45888">
        <property type="protein sequence ID" value="OXR45888"/>
        <property type="gene ID" value="B7C42_02180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="32060" checksum="52D5DCE898BC4699" modified="2017-10-25" version="1">MWIVDAMAGASAALRSVIGGGDRTYEAKAVVTGAGSGIGRAFALELARRGGEVICADIDLGRAEETVALIDRTHGRRAHAFRCDVAERAEMESLARHSVSIFGAPPTLVINNAGVGIGGKPVGDIGFEDWQWALGINLWGVVHGCELFVPQLRRAGRGGIINVASAAGFAAAPAMAPYNVSKAAVVSLSETLAAELSGTGVAVTVLCPTFVRTNVARDGRITAGSARLATELMRWTGFSPDHVARITLDAHERGRLHVLPQLDAVVVWHLKRHFPATYTRALGVLNRVLPHDDSAPAPAGSAKTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB33</accession>
    <name>A0A231HB33_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-methylmercaptopropionyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="10">1.3.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dmdC_1</name>
        <name evidence="10" type="ORF">B7C42_01018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.-" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46055">
        <property type="protein sequence ID" value="OXR46055"/>
        <property type="gene ID" value="B7C42_01018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="287"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="474"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="608" mass="65718" checksum="DFF96D01D35AA0BE" modified="2017-10-25" version="1">MSHYKANIRDIEFNLFEVLGIGALLEAGAYGDLDTETARGMLTEVQRLAEGPVAESFVDADRNPISFDAAEHEVVVPDPLRKTVAAVNEAGWSGLGMPEGMGGVDAPSPLIWATQEMLVAANNSASFFNMGPLMHQVLYREGTEEQRRWAEHAWENRWGGTMVLTEPDAGSDVGMGRTKAVQQPDGTWHIEGVKRFISGGDVGDTADNILHLTLARPEGAGPGTKGLSLFVVPKYLFDSQTMELGERNGVLVTNLEHKMGIKSSPTCELTYGGDKPAVGYLVGDVHNGIAQMFKVIENARMMVGVLSAGTLSTGYLNALEYAKSRVQGADLTQMADKTAPRVTITHHPDVRRSLALQKSYAEGLRALYLYTAAYQNDDVAQANFGADPDTAARVNDLLLPIVKGVGSERAYETLTETLQTFGGSGYLQDYPIEQYIRDVKIDSLYEGTTAIQAQDFFFRKIVRDKGVALAHVAGLVQQFVESEPDTLKAEKTLLGAALADVQAMATALTGYLVAAAQTPEEIYKVGLGSVRFLHAVGDLVIGWRLLAQAQVAQAALAGQPSEKDRLFYTGKVGVASWFAKNQLPLLSGVRAVVENLDTDIMQLEEGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA7</accession>
    <name>A0A231HBA7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46046">
        <property type="protein sequence ID" value="OXR46046"/>
        <property type="gene ID" value="B7C42_01009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="22975" checksum="62E0F2B0FD34B352" modified="2017-10-25" version="1">MSSEAESRGRAVRGYGGISAAERRERRRTALLDAALDLLAEGGAGAVTKRAVCARARLNDRYFYEHFADRDLLVQALAGQLTADGIAAVISATLAAGPDLREQVRAAADAALGFLAADPRRQALVLASHSDAALQSGRLSTQREIAAAMAAVVRELRPPDPAAAPLDLDMTAYAVVSGTLELVAAWIRGEFRATRTHLTELIAALLLAGTAITPAAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBF6</accession>
    <name>A0A231HBF6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigW</name>
        <name evidence="8" type="ORF">B7C42_01114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46149">
        <property type="protein sequence ID" value="OXR46149"/>
        <property type="gene ID" value="B7C42_01114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="30820" checksum="D3C3DC923E28BBD4" modified="2017-10-25" version="1">MSVDDADERVAETALVDRAVAGDRSAVTEVVRLLQDPLYRLALRMTGNPSDAEDAVQEILLRAVGNLASWRGEAKLTTWAYRIGVNHLLNQRRRSPQESAHLDLDGFGANLLEGLAEQDYRGPEATVLTREVRLVCSQAMLQCLARDKRVAFVLADVFELSSAEAAWILGIGAAAYRKRLERARTRLGNFLDSTCGVANPAAPCRCSRRVRTAVDQGRVRPGRPGLAGHPVTPGGRSAADAEAQMAGLHDAASILRAHPDYALPPARLAAIASLLDSGRFPLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBN9</accession>
    <name>A0A231HBN9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_01198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781522.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46232">
        <property type="protein sequence ID" value="OXR46232"/>
        <property type="gene ID" value="B7C42_01198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="183"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="31465" checksum="214B4FECA8EA40E7" modified="2017-10-25" version="1">MATRTISLNEPPKTGSLYLKAALGAVPLPLVSARKSEIPDRAVEWNGVRVDPDHLAAYCHATGLRFGDSLPLTYPFVLTFPVVMQLVVARDFPFVAVGAVHAENLIERTREISVSEPLDIRAHVENLREHPKGLLVDAISEISVGRELVWRQVTTFLHQQRTSLSGGPKAAPKPDEVPPPPLRTLKVDQAMIHRYAAASGDRNPIHMSALGAKAFGFPRSIAHGMWSAAAILGVIEGRVPAKTSYAVKFGKPILLPSTVNVYADQTAEGWDLSLKHPKKGYPHLTATLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBW3</accession>
    <name>A0A231HBW3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arginine transport system permease protein ArtQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">artQ_2</name>
        <name evidence="11" type="ORF">B7C42_01275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781600.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46309">
        <property type="protein sequence ID" value="OXR46309"/>
        <property type="gene ID" value="B7C42_01275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011296671" evidence="9">
        <location>
            <begin position="37"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="374"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="598" mass="63427" checksum="2A784C028D5A2AE2" modified="2017-10-25" version="1">MARLPVSRPRALIALMAAMMLLFAVACSSDGGSSSQASNLCAPPGPSAASPAPTKLASGATAGTDRYTTATTAPLNSIDITKLGLSQPGVLSVGTLSDAPPSICVNPSGTFTGFDNELLKAIGAKLGLRVQFSGTEFASLLSLVATGRFDVGSSSITTTDARRQQVGFTNGYDFGYFSLVVPNGSAIHGFSDLKPGVRIGVVQGTVQDEYVTGTLHLDAVKFPDYNTAYANLKTGQIDAWVAPSQQATGAIKPGDPTSIVQNTFSLDNFTAWAVRKNNQPLIDALNSGLDAVIADGTYAKLYSDWVPRPLPPGWKPGSKSAPMPQLPDFEKIAAEHQHSDQQNAPKSTLTQLKETFFDWSLYRKAFPDLFKTGLPNTLILALVSGVLGTLIGILLAVAGISRTRWLRWPARVYTDIFRGLPAVVIILLIGLGIGPVVKGITGNNPYWLGAVALALLASAYIGEIFRSGIQSVEPGQLEAARAIGFGYRQSMTLVVIPQGVRRVLPALMNQFIALIKDSSLIYFLGLLASQRELFAVGRDLNSQTGNLSPLVAAGLVYLLLTIPLTHLVNYIDRRLRTGRAEAAADEIDQAVITEGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBZ9</accession>
    <name>A0A231HBZ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781751.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46411">
        <property type="protein sequence ID" value="OXR46411"/>
        <property type="gene ID" value="B7C42_01377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="119"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="36578" checksum="6160CFD642850BDC" modified="2017-10-25" version="1">MRGIRKPLIGFGIFAIVSVLVTVVIWNTLARTVNGSTHSYSAIFTDVLGLREGDDVRMAGVRVGKVTKIEVEGQHQAKVSFIVQTDQTVYGNTKALVRYQNLIGQRYVALAPGNKGDNSALRNNATIPVDRTEPSFDISGLLNGFQPLFETLQPQQVNDLTNTFIQALQGDGVSLSSFITQAAALAGDFQRRDVILADVITKLSGVMSGLAKRGDELETLVTQTRALIGGLYEQGQSLQASTVQIANATSSLVNMVDQVQPKIRAAQNSSTDALTMLINNGAKLDQAAVDLPGILADVGKFTSDGAYANAYLCTLDISLYGVLLPRGLVSQIGGPNHSAVCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC18</accession>
    <name>A0A231HC18_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">drrA_2</name>
        <name evidence="6" type="ORF">B7C42_01262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46296">
        <property type="protein sequence ID" value="OXR46296"/>
        <property type="gene ID" value="B7C42_01262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="312" mass="33484" checksum="0759C99B6C73A617" modified="2017-10-25" version="1">MSSPAISVTGLRKSFADHVVLDGIDLTVPEGRIFALLGPNGAGKTTTVHILATLTRPDDGSLRVGGHDPVAEPDAVRTAIGVTGQFSAVDELLTGRENLLLMADLHHLPRSEGRRIAEDLLARFDLRDAADKVAGSYSGGMTRRLDLAMTLVGEPRIIFLDEPTVGLDPRSRRGMWDIIRELVADGVTIFLTTQYLEEADQLAHRIAVLDHGRIVAEGTPEQLKRLVPGGHIRLTFGDDEQLRSAAGLLGGTTTDSTLAVPSDGGVASLRDVLDRLGRAHIEPESLSVHTPDLDDVFLTLTGHTAPEKETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD05</accession>
    <name>A0A231HD05_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46655">
        <property type="protein sequence ID" value="OXR46655"/>
        <property type="gene ID" value="B7C42_01629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="38487" checksum="CD2CE0251508C457" modified="2017-10-25" version="1">MTVDRAGDLEIHPDGSATWTAPVHIGAPEPLIPPAVWDAAVAEPRDILDDIDAVLAEGEPETGYDFGDPTFPRCPRGCGREWHGMAVTRRIEHMRFRGTMDPDYRYDTDDSEVLCPAPDFIGPFMPPYYARRRDINFAVSIEAEARRRTRAFIERTWAQIWELLMPGTEPVLDAARWFDPPRETEQRAPVDCSALRFVDASEFRPRLVPWQRDVLAAITSPSTVRIPREYQYPRRTWLHQQLQIVRDRLPRRGEQPSIIIIDECLPDPDPIAEAAEMAIREHDRPAVDPESAARAALDARPIRVAGARPIPREIDGFPSGQPAHARFGSNASRNRRGSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD37</accession>
    <name>A0A231HD37_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46706">
        <property type="protein sequence ID" value="OXR46706"/>
        <property type="gene ID" value="B7C42_01682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="26228" checksum="F3AC5B1D41847D7D" modified="2017-10-25" version="1">MAVIPAVTVAVDFGGGGLVVETTAGSRASGGMVAGFAGGLTGIRAERAACVEVRMSPLRAYSVLGVGPGELGAAVGLDEVWGVSAERLRAQLAEAVGWEERFGLARAFLAQRVRPERTPDPEVVAGWDRIVASRGQVRVAEVAEFCGWSRKRLLTRFESQIGLTPKRAAMLVRFRHAVEGLVAGRRAADVAVSCGYSDQAHMSREIASFAGRTPGALARETHTPIGQHRYRAWGTFFQDPAGVAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD72</accession>
    <name>A0A231HD72_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ENDO3c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497177.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46746">
        <property type="protein sequence ID" value="OXR46746"/>
        <property type="gene ID" value="B7C42_01724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017658">
        <property type="entry name" value="CHP03252_HhH-GPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03252">
        <property type="entry name" value="TIGR03252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="28"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="21982" checksum="B55E42C25A90C2CA" modified="2017-10-25" version="1">MVSRKVCLAQEPESDKLLSEDDFALLTGMLLDQQFPLEHAFRGPKKIADRMNGFDIHRIAEADPEEFEELGATPPAIHRYGRSMARRTQELARYVVEHYDGITSEIWTRDDPDGKEVLRRLKELPGYGDQKARIFLALLGKQLGVRPAGWEKAAGAYSEPNSRRSAADIVDNESLLEVRAFKKQMKAAAKEAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDA2</accession>
    <name>A0A231HDA2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46933">
        <property type="protein sequence ID" value="OXR46933"/>
        <property type="gene ID" value="B7C42_00049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="10018" checksum="FC3301FAEFC1372E" modified="2017-10-25" version="1">MIIDPVDPIQHLIGAIAWLLIRGQLHGPDTCLEHESSVEFRYENRTWRPTFDPARPAVYPTHPQHRYSARHVPCSNRWPRAPARGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE79</accession>
    <name>A0A231HE79_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligoribonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">orn</name>
        <name evidence="3" type="ORF">B7C42_00125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47007">
        <property type="protein sequence ID" value="OXR47007"/>
        <property type="gene ID" value="B7C42_00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="5"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="212" mass="23352" checksum="B6D84D794897F0EA" modified="2017-10-25" version="1">MSDKLMVWMDCEMTGLRLDSDKLIEVAALVTDSDLNILGDGVDIVIHADDDALAAMPPVVQEMHAKSGLTEEVRRSTVTMEEAQQQVLDYVREWVPTPGTVPLAGNSIATDRGFIARDMPELDAHLHYRMIDVSSIKELCRRWYPRIYFGQPEKGLAHRALADIEESIRELRYYRQTAFVAAPGPSTAEIAEIAAQVSAGSTGTQPPATPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEH7</accession>
    <name>A0A231HEH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47242">
        <property type="protein sequence ID" value="OXR47242"/>
        <property type="gene ID" value="B7C42_00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="280" mass="28434" checksum="C3637B53318995DF" modified="2017-10-25" version="1">MTVVVVTDSAASVPAALVSELGIVVVPLHVLVDDRAIAEGVDDCDIDYGASTVTTSSASPGELRAAYERALELSAGDGVVAVHISRQLSATWEAGRQAVQDMDAADRVRLVDSLSAGLGTGLPVLAAARRARSGAALDVVYDTAVAAAGRSRTFIVVNRTEQLRRGGRLSTAAMFFGTELVTKPILQIVDGKLELREKARTRSKAYAKLVAAAVDAAGDDGAAVAVQHLGAASAAATIAGQLGELIPGMRELVTAEFGPTLGVHVGTGAVGVLVVPGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEI3</accession>
    <name>A0A231HEI3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47107">
        <property type="protein sequence ID" value="OXR47107"/>
        <property type="gene ID" value="B7C42_00229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="31783" checksum="5BFDBCEFE0140A8D" modified="2017-10-25" version="1">MSANTRIQSPLLPWPSEWGPQRPPAKLLLALGFFSLCVLIAIPYAIDFATHGDTLRAFYGVLGGVVAASFVLMLLPSLRVRRKSLPANLHVGTSGLLIEVKSSWRPVLMLWLVTGVIFLVVRGALFVRHLSSDDDGVGSAIDVGGIVIVAVVLAVIAFLVFFLFGRHRRYNVVLSPGGISQGMGRTVRTMSWDQVGGVLPDIVNSAHTVRTYPTAGARVDVESGRGFLDRLQQGLLEQSIDVAAWTLALDPSLLLYLIRYYWQHPEARDELTSNAVVDRMRRGELLTGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEK8</accession>
    <name>A0A231HEK8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47411">
        <property type="protein sequence ID" value="OXR47411"/>
        <property type="gene ID" value="B7C42_00534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="453" mass="50133" checksum="C69E3E20F5C09F33" modified="2017-10-25" version="1">MTKTVADPVPGEPLSTGRAVRATVPRSSLGEFRPAPDRDPIAILERQAETRLPDLVPIRYARMAAGQFPFLRGAPAIMAADLATIPHTGLTVQLCGDAHLSNFGIFASAERSLVFDLNDFDETLSGPFEWDVKRLVASVVVASREKGFTDEEATAAARTAATAYRECMRRLAGMDSLDVWYEKVDEDTVANMVSRPKFREGVDRAFEAARKRTSLGALSKLTHTDEQGALRIRHRPPLLTPVDYVDAQTVEEVFSAYRRSLPEERRVLADRYRIVDYAHKVVGVGSVGTRCYVILTVDRDTGGPLFLQMKEAEKSVLEPYLAPSRFQHQGHRVVHGQRLLQTSSDIFLGWVSGPNDRNYYFRQLRDMKGGADITQMAKTALRDYAGICGHTLARAHARSGDRIAIADYLGGGEAFDKAMTQFALTYADQTATDHRELLRAIDSGRVQAAANPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HES5</accession>
    <name>A0A231HES5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">iscS</name>
        <name evidence="9" type="ORF">B7C42_00485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47362">
        <property type="protein sequence ID" value="OXR47362"/>
        <property type="gene ID" value="B7C42_00485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="16"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="42121" checksum="1C5E0281BB3BD721" modified="2017-10-25" version="1">MMSAFPGPVAAAPKTVYLDHAATTPMFPAAVEAMTAVLGTVGNASSLHGSGRTARRVLEEARESVAADLGARPSEVIFTSGGTESDNLAVKGIYWARRDADPRRTRILVSSVEHHAVLDAVDWLQQHEGAQVTLLDVDAEGVVSPGALRGALSAHADDTALVSVMWANNEIGTIEPILELASVAQEFDIPMHSDAVQAAAQLPIDFASSGLAAASFAGHKVGGPHGCGVLLLGRQVGCVPLLHGGGHERDLRSGTSDVPAAAGIAAALRETVREMPARTVELIDLRDRLIAGVRDAIPGAVLNGATGDRRLPGNVHFTFPGCEGDSLLMLLDAAGIECSTGSACNAGVAAPSHVLLAMGVEPRQARGSLRFSLGHTTTVAEIDRVLEVLPSVVERAEAAGLAGAKGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEX2</accession>
    <name>A0A231HEX2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane transport protein YnfM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ynfM_1</name>
        <name evidence="7" type="ORF">B7C42_00407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47285">
        <property type="protein sequence ID" value="OXR47285"/>
        <property type="gene ID" value="B7C42_00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="424" mass="43304" checksum="3619889FFC20CF58" modified="2017-10-25" version="1">MTSATVTTAPIRTAEDARHERRITLALFAAGLTTFGSMYSAQALLPSLSTAFGATPAHAALAVSLTTGLLAVAIVPVSVLSGRFGRTRVMIASAVATSVIGLLLPFSPNLDVMLAGRAVQGIAVAGVPAVAMAYLAEEIGSAGLGAAMGIYVSGTTVGGLAGRLIPAFTLEVASWRWGATIFAVGAALCTVWFVRMLPPSRHFVARPLGIGALLGDLAAHLRNRALLPLFGLAFLLMGGFVSVYNFLGYRLIQSPFGLSAATAGAVFLMYLSGTVSSTAAGRFADRLGRFPVVAISIVTMGLGLLLTIPDHLAILLPGLLLFTAGFFGAHAVASAWVGATATGNRAAASSLYLFAYYVGSSIVGALAGLAYSRHGWAGLVLYVGALIVVAAALVASLGFRLRADSASRRSAGTSADTRRGGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEZ2</accession>
    <name>A0A231HEZ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47432">
        <property type="protein sequence ID" value="OXR47432"/>
        <property type="gene ID" value="B7C42_00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011227827" evidence="2">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12541" checksum="599146B7D3BD37E2" modified="2017-10-25" version="1">MIARTEHRTKRTAARIAVAGAIVAAPLAALAIPAQADVVSAPAATDIAHPGHGHGPFGGLGDWDRRGDWDHRGDWDHRGDWDRHRRGDDCNPWDRHGNGWNGFRQVVPPGWFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF77</accession>
    <name>A0A231HF77_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47631">
        <property type="protein sequence ID" value="OXR47631"/>
        <property type="gene ID" value="B7C42_00756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325519" evidence="1">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="13940" checksum="075A4693AE80D194" modified="2017-10-25" version="1">MAVGMRRIGATAAAGALGSLLAVSVAGADVTGVRVDAGADGLRTGCPVTLTATVDTPVPDGGTVTFINSGGAVPGNGEPIAGTPVHHPENGTVTMAWTPKYAGRQNITAQQFKPGSYTSSSYVTVDVAGSGLNTGSSCLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFC1</accession>
    <name>A0A231HFC1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxylate/hydroxypyruvate reductase B</fullName>
            <ecNumber evidence="4">1.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ghrB</name>
        <name evidence="4" type="ORF">B7C42_00775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.79" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47650">
        <property type="protein sequence ID" value="OXR47650"/>
        <property type="gene ID" value="B7C42_00775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="32"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="109"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="34521" checksum="1BFCD422B4678ED9" modified="2017-10-25" version="1">MNAGPVVTVLHDGVEPDAVSLRPVSQRATVRFADGAELADALPGAEALFVYDFQSTALRGAWHRADRLRWVHVGGTGVDAVMFDELIDSDVLVTNTRGLFDQPIAEYVLAQILAFAKDLPESLRLQQRHQWHHRESERVAGAAALVVGTGSIGRAIARLLRAAGMRVRGLGRTARTGDPDFGTVATDLHAELPGADYVICVAPLTPQTRQLFDANAFAAMKPHARFINVGRGESVVTDDLVAALRGGALAGAALDVVDPEPLPAGHPLWDLPNVVVTPHNSGDFIGWRSEIVAAFTDNFQRWITGQPLQNVVDKKLGYVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFJ2</accession>
    <name>A0A231HFJ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">L-2,4-diaminobutyric acid acetyltransferase</fullName>
            <shortName evidence="6">DABA acetyltransferase</shortName>
            <ecNumber evidence="4 6">2.3.1.178</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ectA</name>
        <name evidence="9" type="ORF">B7C42_00621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16901"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="2.3.1.178"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the acetyltransferase family. EctA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.178" evidence="4 6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47496">
        <property type="protein sequence ID" value="OXR47496"/>
        <property type="gene ID" value="B7C42_00621"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033816">
        <property type="term" value="F:diaminobutyrate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012772">
        <property type="entry name" value="Ectoine_EctA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02406">
        <property type="entry name" value="ectoine_EctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16590" checksum="73CE1B0FB9DE0B1F" modified="2017-10-25" version="1">MWRIAVDSQVLDANSSYSYLLWSRDFASTTVVAEIGSEIAGFVTGYLRPESPDTLFIWQVAVDHAFRGRGVGVAMLDRLVEDVADQGVSKLETTVSPDNEASLAMFASLARRRDAEMTRETLFEPEDFPDGHESEDLYRIAPLQGDAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFS8</accession>
    <name>A0A231HFS8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779532.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47668">
        <property type="protein sequence ID" value="OXR47668"/>
        <property type="gene ID" value="B7C42_00793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="18259" checksum="1C96983543BF2401" modified="2017-10-25" version="1">MKERDSGRQVLRIVAFIAFLVVALAFYFLLLGRIAIELMTSGKAAAVAMGVGVLILPILGVWVVATSIRAALAHQHLARRIHDEGLELDVSELPRRPSGRLEKAAADELFEQVKKEWEADPDNWRTNYRAARAYDYAGDRSRARDTMRRAVELERVERRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG59</accession>
    <name>A0A231HG59_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Steroid C26-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.13.141</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.141" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47818">
        <property type="protein sequence ID" value="OXR47818"/>
        <property type="gene ID" value="B7C42_00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="413" mass="46175" checksum="614251B2A9C13D23" modified="2017-10-25" version="1">MRATRPDIPANFDVTDPDMWARRVPVDELAELRRAAPIWWNSKPPGSDGFPDDGFWVVTRHADVKEVSRRSDVFSNAENTALPRYGVELTPERMDMQRLVLLNQDAPQHTRMRKLISKGFTPRAVNGLRAELSARAEAIVAAAAEVGAGDFVTQVACELPLQAIAELIGVPQEDRMKIFRWSNEMIGYDDPEYAGVDPLAASTELLAYAWQMAEDRKSRPADDIVTELVHADVDGEALTSEEFGFFVILLAVAGNETTRNAITHGMIAFLENPGQWELFKSQRPTTAVDEIVRWATPVSTFQRTALEDTELGGVRIRKGQRVLIVYRSANFDEEVFDAPFTFDITRDPNPHLAFGGTGAHFCIGANLARLEIDLIFNAVADHLPDITKLGDPRRLRSGWLNGIKEFQVRYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSD9</accession>
    <name>A0A231GSD9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Riboflavin biosynthesis protein RibD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ribD_3</name>
        <name evidence="2" type="ORF">B7C42_08385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000616">
        <property type="protein sequence ID" value="OXR39547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39547">
        <property type="protein sequence ID" value="OXR39547"/>
        <property type="gene ID" value="B7C42_08385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="7946" checksum="17FAC917568F72AF" modified="2017-10-25" version="1">MNKLDPPDPRLAGATVYSTLEACSQRATAGRPPCTDRILAAGIPRVVIAWREPSTFVVNCVGVEKLREHGSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSR0</accession>
    <name>A0A231GSR0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative citrate synthase 2</fullName>
            <ecNumber evidence="1">2.3.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">citA_2</name>
        <name evidence="1" type="ORF">B7C42_08347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000269">
        <property type="protein sequence ID" value="OXR39585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39585">
        <property type="protein sequence ID" value="OXR39585"/>
        <property type="gene ID" value="B7C42_08347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="54" mass="5851" checksum="E90FC24CE58C239A" modified="2017-10-25" version="1">MMPAMFTCGRTAGWCAHILEQKQLGKLVRPAAIYTGPGPRKPAEVAGWSDISHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT84</accession>
    <name>A0A231GT84_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent stearoyl-CoA 9-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">desA3_7</name>
        <name evidence="3" type="ORF">B7C42_08167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000071">
        <property type="protein sequence ID" value="OXR39755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39755">
        <property type="protein sequence ID" value="OXR39755"/>
        <property type="gene ID" value="B7C42_08167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="95" mass="10413" checksum="8E6A58F9D76722F2" modified="2017-10-25" version="1">MLTSRNVRGGALTDIALGGLNYQIEHHLFPSMPTPNLRRAQVIVREYCAEIGVPYHETGLVASYREALRHLHDVGVPLRAGGPRQEPIEGSTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTB7</accession>
    <name>A0A231GTB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000079">
        <property type="protein sequence ID" value="OXR39721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39721">
        <property type="protein sequence ID" value="OXR39721"/>
        <property type="gene ID" value="B7C42_08209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="58" mass="5499" checksum="58615C083A10BB9E" modified="2017-10-25" version="1">MGCACGAGRGTGPGQSAAGYLVTTVTGEKLGPYLTMTEARIAATAAGGGTVKPLLEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTD6</accession>
    <name>A0A231GTD6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782306.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39884">
        <property type="protein sequence ID" value="OXR39884"/>
        <property type="gene ID" value="B7C42_08030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="7032" checksum="808A752475B02163" modified="2017-10-25" version="1">MAKVTIEGVINSDVCARGKRYTVEMTDQLRGLLGSGIVKVVDWHHDDEPAAPARKRRRARDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTE4</accession>
    <name>A0A231GTE4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043538.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39890">
        <property type="protein sequence ID" value="OXR39890"/>
        <property type="gene ID" value="B7C42_08036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="26072" checksum="3FC679170E2059A7" modified="2017-10-25" version="1">MLTLGAVAGRLRLALDPAADFVGRVQLQQPLGTPMPWPTGTSAWLHLSARGTSFDVQWPATISGSLMSWHQVAADVAAVPLTSWAELWLDYPDNPPFVWLKGPVESGCASAGFGGIVAVPGISDGAVAVPVPGPAGPPGSGEGGAAVIVTGTAGAALSGHRAVVRNASGAWVYADNQTAGHIGLPIGITTGAAASGDPVSVVMVGDLTEPSWAWTPGPIFLGAAGALTQSVPTSPALFVAQIAAATSGTTVFVDRSPSIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTG2</accession>
    <name>A0A231GTG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782348.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39910">
        <property type="protein sequence ID" value="OXR39910"/>
        <property type="gene ID" value="B7C42_08015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17874" checksum="71635678F58DE478" modified="2017-10-25" version="1">MIIFTPEHIAAAKAVVNADAEVDSYRYDEPYSEGQEWFAWNDRLNAAQEAQDQAVAAFRALLGDLDPTDVAQGAPINPLTETLTEGVYHTHDHRFFASAYYRGEHAGKWAVDVYDPPIGEQDFRIVVRLVATDRQHAQQMVDLATWALGAGARTSEPVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTM1</accession>
    <name>A0A231GTM1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mlaE_30</name>
        <name evidence="3" type="ORF">B7C42_07949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39970">
        <property type="protein sequence ID" value="OXR39970"/>
        <property type="gene ID" value="B7C42_07949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="28662" checksum="21207DD894C4A8E3" modified="2017-10-25" version="1">MTGSPETGSSTPAAVMRRTSRVSKSADTALRGVGAFFEMCAATFRAMVKPPFQWREFVLQSWFIVRVSMVPTLMVAVPFTVLVVFTLNVLLVEFGAADLSGAGAALGAVTQIGPLVTVLVVAGAGATAICADLGARTIREEIDAMRVLGIDPIQRLVVPRVLASTVIALLLNGLVITIGIVGGFIFSVFFQNVTPGAYVSSLTFVTGTPEVVISECKGCIFGLIAGLVACYRGLTVKGGAKSVGDAVNETVVYAFMALFAVNVIATAVGVKYGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTM3</accession>
    <name>A0A231GTM3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39928">
        <property type="protein sequence ID" value="OXR39928"/>
        <property type="gene ID" value="B7C42_07991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="78" mass="8975" checksum="9DA49591569D3610" modified="2017-10-25" version="1">MEAGNDVLRDAERNMLQLGEEARPLGELLRRYEAADLVQSPLEDIVRLRELLQRSEQLVSDIGRRFADNANNLIDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTM6</accession>
    <name>A0A231GTM6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DevR (DosR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">devR_4</name>
        <name evidence="5" type="ORF">B7C42_07952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39973">
        <property type="protein sequence ID" value="OXR39973"/>
        <property type="gene ID" value="B7C42_07952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="322"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="393" mass="42500" checksum="42966AD8625127BC" modified="2017-10-25" version="1">MRAPAVAAPQHTFAGLVSRISDLNARVGQLAEHARVGSGANRPYLQLLGVTLERTNRRLASARGGAVDATDLAELLTDVTAVQSTLRKQTLTQPSFAPGRIFEALARLRRKTTAEEVFEAAAAEVCAAAGFDRAMVSMVRGSVWAPSLLFLSDGNDSGFNRELTDYIAELEIPLASPMVEAEIVRRRLPALVTDAQDEPRTFAPLMTASHTREYVAAPLIAGGSVFGLLHADTYLSGRPLTVADRDSLRTFAEGIGVIYERTVLESRLTSQRERLSEVFRTAEQILETPRKMMVRLPGPAVRTAVSVTAEGSATREDAGRMELGGMARLTAREREVLALLAGGLTNAQVADRLTVAESTVKSHVKHILHKIGAPNRASAIAQYIRATNNERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTV7</accession>
    <name>A0A231GTV7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(R)-citramalyl-CoA lyase</fullName>
            <ecNumber evidence="5">4.1.3.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccl_2</name>
        <name evidence="5" type="ORF">B7C42_07936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.46" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39985">
        <property type="protein sequence ID" value="OXR39985"/>
        <property type="gene ID" value="B7C42_07936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044101">
        <property type="term" value="F:(R)-citramalyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="33177" checksum="002CE319CD355C35" modified="2017-10-25" version="1">MIDHSTTILRDVTLRDGLQLTGTPLATHRKLEIVRTLLELGVPELEIGSLARPDLVPSMADTLELIAELTPEELERCWVWVATPRHVAKAAAAGATRFQYCLSASDAHNRANIGRDTATSLDAFPEALGAARDIGGRIQLCIATAFTCPFEGPVPEQRVLDIVADPRTDGAHDTVLCDTLGQAIPAQVASLVGQTTALNPQRRTIFHGHDTWGMGVANALAAIAAGAQVVDGALGGLGGCPFAPGASGNTATEDLLFATRPSYLDPSVFRRVVETSERLLSELGETPRSQAAQGARSRANAFEWVIPDTTASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTZ1</accession>
    <name>A0A231GTZ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase</fullName>
            <ecNumber evidence="2">4.2.99.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">menH_5</name>
        <name evidence="2" type="ORF">B7C42_07909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.20" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782738.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40025">
        <property type="protein sequence ID" value="OXR40025"/>
        <property type="gene ID" value="B7C42_07909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070205">
        <property type="term" value="F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="33412" checksum="BD62584E090FE8CF" modified="2017-10-25" version="1">MRVTDTSLLAMTTSDGLMLAGDRCGPSFAAATVVYVHGLLCDGSWWQPLTKQVHERLDGQIAQIVWDQRGHGHSGRPHRSVETTLEHLADDLDTVLTEATGSIVLVTHSAGSIVAAAYAQRYPARAAALSGLVLFNATGEFPEFPALPQHFASAAARIKGLRHGRLDHVAAAAASVAERRFRRTARRLGSKAPLATGARPGDPRVLTDLMHAYRHFYLDPQTAVRLRSLPSFVVTGDRDRVVPAAQSTRFAEKIWADQQVVPGAGHSLPRSDPELAAEVIVAALDVAYRADVDQLLLDQDGELAADTDGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU06</accession>
    <name>A0A231GU06_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan endopeptidase RipA</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ripA_6</name>
        <name evidence="4" type="ORF">B7C42_07950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39971">
        <property type="protein sequence ID" value="OXR39971"/>
        <property type="gene ID" value="B7C42_07950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="320"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="444" mass="45828" checksum="D3876D3B6F22F3B4" modified="2017-10-25" version="1">MSDPISVIATIVMSATGAIDNANLPSAAKASAHAAVESGGDAATSFSVRLDRAVAQLPEPAQQSARTAVDAAYDRMAAMVPATNAPAAQSTTDQTPDPVVTAPGDDEHVAEPPRTDSQASPEPTGTQYAVAPSRPISIPVPDAAAVPPSTITGRIAAFVPWFQKAGTLCSGIKAPTLAALYAAENGFRYGPDAPVSPTGALGPGQFMPGTWAVYGKDVHGTGTPDVFDIGDSVMASGHLLCDSYRQIESWKAEGRVVGDTLDLTLAAYNAGAGAVLRSGGMPSGSPDYEHQTKPYVARIRATEKDYGWLAQEPGLLRPASDIGTRIVEQAMKYLGIPYVWGGGSSNGPSMGGFDCSGLTSFAVHSATGGTVTLPRTSQGQWQTGSEIPLRDAAPGDLLFGNWGPGGPGHVAIYLGNNRMIHAPQPGDTVRISPVMSGMHARRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU10</accession>
    <name>A0A231GU10_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator DegA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degA_2</name>
        <name evidence="5" type="ORF">B7C42_07821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40113">
        <property type="protein sequence ID" value="OXR40113"/>
        <property type="gene ID" value="B7C42_07821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="35194" checksum="6B7176E378C4EA19" modified="2017-10-25" version="1">MVVSIREVAQRAGVSLGTVSNVLNRPEQVSPATRRRVEAAIAETGYVRNDSARQLREGSSRTLAMVVLDMANPFFTDVARGAESEAERAGAMLVLCNSGDDQQREQRHLEQIAQQRMRGVLITPVDGDGEAALKTLAAQGIPAVLVDRGSRRHDRCSVSVDDVLGGELAARHLIESGHRHLAFVGGPLTVEQVADRLRGAREASEEAGCRLDVVATAALTVEAGRAATETILDADPRPTALLCANDLLALGALQALTARGVPVPAEMAVIGYDDIDFAAAAAVPLSSVRQPRAELGRAAARLLLEEAGAQGDHRHQHVVFVPELVVRRSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU65</accession>
    <name>A0A231GU65_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane protein YbjJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybjJ_3</name>
        <name evidence="7" type="ORF">B7C42_07752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40170">
        <property type="protein sequence ID" value="OXR40170"/>
        <property type="gene ID" value="B7C42_07752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="218"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="39933" checksum="3303EF348670FD14" modified="2017-10-25" version="1">MLDTDTNSPQDVRDSALRSARGANSVAFALQGFFLALVLTELPQEKEKFGLDDTMLVMIVAGISLLAGLGSVIAERVALRWSSRTALRIALGLVAVAGAGIALSPNTTALVVWLGVYGVALGGVDAGTNMQAVLIQHGYGRFILSSFYAAWSTGAILGALWVSAAEAAGVSTPVTILIAGAVVAVAGQGSSPRLLSAAAGESGPAEHGSPRPVPARVLLLFGVVLALAFAIDLAVGNWSALYLKDELGAPAAIAALALAAYQGASLAGRLAGDTLVRRFGPRHVSRVAALIGAAGLAVVALVPAPAAAIAGFLIAGIGLPLIAPLCFSELGRRTSGPGLDAVIARLNLFNYAGTLIGGAVVGSVAAAAGMRAGFAIPLLFALALAGLARTFAHRSAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUG7</accession>
    <name>A0A231GUG7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">atpF_2</name>
        <name evidence="13" type="synonym">atpF</name>
        <name evidence="16" type="ORF">B7C42_07733</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776814.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40218">
        <property type="protein sequence ID" value="OXR40218"/>
        <property type="gene ID" value="B7C42_07733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR40218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="20363" checksum="2C8333C02C3DD9D2" modified="2017-10-25" version="1">MNSMYLLAENAEDKNPLIPEPYDIVWSVVCVVVIGILFYKYVVPRLTKVLDERSEKIEGGMAKAEAAQAEAQETLQQYQQQLAEARLEAARIREEARTQGQQILAQLRSEAQAEADRIVSAGHAQLDAQRQQIVTELRSELGRTAVDLAEKIIGQSVADEAKQAASIDRFLTELDQKAGIGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUS7</accession>
    <name>A0A231GUS7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40295">
        <property type="protein sequence ID" value="OXR40295"/>
        <property type="gene ID" value="B7C42_07633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="27638" checksum="545685DC7DE9B9C8" modified="2017-10-25" version="1">MCILTFYKPGRDPDLEALHGGALANPHGHGYAIHTGKTILVGHGMNSDDVIADFAEQRAEHPGGPALFHSRYATHGDRDTSNCHPFTVGGDPRTVLAHNGVLPPNVHPAAGDARSDTRIAAEDFLPTTPFGSLDSWAGRDRFEHWLGSNKVVILTTDPAYKHPAYIFNERHGHWVGGTWYSNDSYLIREWASADTDYVGFCEYCGAFEDDPFGPHCGWCGYCADCAHPFPRCACPQFDGVDRYADLLGLPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUU0</accession>
    <name>A0A231GUU0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator WhiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">whiB_2</name>
        <name evidence="2" type="ORF">B7C42_07676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40251">
        <property type="protein sequence ID" value="OXR40251"/>
        <property type="gene ID" value="B7C42_07676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="110" mass="11676" checksum="19BEC5B3E1F7C454" modified="2017-10-25" version="1">MKKATLQRVSPQDWSDRACLGLPLDLFFPDREAQAAEAVEVCEGCPRRIQCAAWALNAGMTHCVVAGVYLPPSTSSKRAKAALDQLREIAESGAAADVSDQEGGTAWTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV10</accession>
    <name>A0A231GV10_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782464.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40311">
        <property type="protein sequence ID" value="OXR40311"/>
        <property type="gene ID" value="B7C42_07649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="7657" checksum="ACD5C1188650CF61" modified="2017-10-25" version="1">MADSPAHLVVDRTACAGHGLCYATAPELLDSDDFGNPVVTSDPVPAAQLDAAHRAAAACPERALTLTSALPLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV30</accession>
    <name>A0A231GV30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Steroid Delta-isomerase</fullName>
            <ecNumber evidence="2">5.3.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ksi_3</name>
        <name evidence="2" type="ORF">B7C42_07514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042671.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40456">
        <property type="protein sequence ID" value="OXR40456"/>
        <property type="gene ID" value="B7C42_07514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="13122" checksum="D7878F1D8EA3E8E0" modified="2017-10-25" version="1">MVDAAKIRLAVERYVATVGSGTSAEIAALFSEHATLEDPVGSEPLVGRVAIEKFYAALDSVKTSTELRTVRVAGDSAAFVFRVVTVTADKVIAIEPIDVMTFDADARITSMRAFWSVVDVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV34</accession>
    <name>A0A231GV34_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAP_DH_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40490">
        <property type="protein sequence ID" value="OXR40490"/>
        <property type="gene ID" value="B7C42_07428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAP_DH_C" evidence="1">
        <location>
            <begin position="149"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="359" mass="38116" checksum="7C80921EA94AA81F" modified="2017-10-25" version="1">MTDGKKRIVLWGTGVVGSMVLAEIIRHPLFELVGVGVSNPDKVGRDAGLLCGGGETGIHATNSVEELIALRPDAVVHYGPTAQFADENIRVIGEFLRAGIDVCSTAMTPWVWPEMAQTPATWRDPITEACAEGGASCFTTGIDPGFANDLFPMTLLGLCGEVESVRASELLDYTSYEGDYEVEMGIGRPPEYQAMLEIPDLLIMAWGATVPMIATAVGIELDTITTTWEKWVTPVDRPSAKGVVAAGNVAAIRFTINGVYHGREVITLEHVNRIGTDAAPDWPAGTKDDVYRVDIVGSPSISQETSFRFTDGSGRTPAVAGCLATGMRALNAVPAVNALPPGWVTPLDLPLVPGVGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV68</accession>
    <name>A0A231GV68_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40523">
        <property type="protein sequence ID" value="OXR40523"/>
        <property type="gene ID" value="B7C42_07462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="26271" checksum="06EA9F7559D042CD" modified="2017-10-25" version="1">MSLTSVARQRVLWGRVIFAGAVPVVIVVAATGVGSAADSGPIASQPGVTTPSQPGTGTPAPPPSPPPPAPVPAAYYEQPPAVRNGPVPRPAPPADPVAPLRVEDLHPPAPVEQVAPIAPPPDEIRVGQFEVPSPPWLPGEVRDAINNTAAGAEAQVATALDSIGIPPGRSDRVGGATLAGAGIGGAIGATITAAPAAAAGAVVGGLVGGTIGGVAGAAVGTVVTVPVIGTITSGVAGTAVGAAAGAAAGAAIAGAPAALAGAVIGGTVGAGFGAAVGVDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC0</accession>
    <name>A0A231GVC0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40573">
        <property type="protein sequence ID" value="OXR40573"/>
        <property type="gene ID" value="B7C42_07382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="563"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="842" mass="89555" checksum="BEF1899128ABED10" modified="2017-10-25" version="1">MVEWSKLPGLPVNTKDSRWLGLMSRGVRGRVSVRVRLLAIVLISSVTLLAIGVGAASYLVRSGRDARQWAELASSTAAPAVAIMETFGEERRLSMLQLAGDPGAATQLTAARQRSDVALAALTAKGDEAQKMNPDNSGADIAAYGQLLAQLPLVRRGVDSGQAPADQVFGLFSRFTAAIIDASMLAARVAPDAGIAVQLGYAVEVMRAAEALSEATALGELFLATGTSTPAQWIQYTNFLGEFRGQIAYARSVLKGERADQLQAIVNSPAWAQVNEMADAVAARGPMAATDDSDPSTRAGETTRSRTSRQSAKPLPMTVQAWQDSSDQLGSGLLTLWQDKSRDAHAEARDQGDRTAIGSLAGGGAVLLVSILAFLASLVLANRFIGRMRRLRRDTLELADERLPDIMRRVSAGETVDAPMEVSRLDFGSDELGQVAQAFNRAQVAAVSAAVAESNTRAGINTIFLDIAHRSQALVHRQLALLDQAERREENADQLELLFQLDHLATRARRNAENLIILGGKQPGRRWRNPVPLIEVIRGAVAESLDYTRIRIGRIPRTRVMGTAVADLIHLLAELMDNATSYSPPQARVEVHAAVVGRGVAVEIVDQGLGMTADELDRRNEMLSYPPEFSVAALSTDTRLGLFVVAKLANRHGISVKLRESVYGGVRAVVLIGTPVLEAGAVNGTDFEDPGPATGEFAVLGPVTNASAARAEVIVAEDVPSATDVAPPPAADPDLSPRRSAWFTSVSERIDSAPATGVFGAPVTSPGVVRAGEGRPPLPRRVRSADRDETPAAGTNAVRQRTADQARNLISAVEQGTRQGRRPAAETGSTASHFDTDEGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVJ6</accession>
    <name>A0A231GVJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40575">
        <property type="protein sequence ID" value="OXR40575"/>
        <property type="gene ID" value="B7C42_07384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="13356" checksum="E5788F43DBD06338" modified="2017-10-25" version="1">MNDGDAWFDDEAGPLVRLYAVTQGRGRSNRPELDMLTLVVDIGRGAALRRHEPEYAAIVELCRTPQSVAEVAARLELPLTMTKVLVGDLIDDGRLEYRQPRQDEASDVGLLQALLDGIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVZ6</accession>
    <name>A0A231GVZ6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsE</name>
        <name evidence="8" type="ORF">B7C42_07083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780105.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40799">
        <property type="protein sequence ID" value="OXR40799"/>
        <property type="gene ID" value="B7C42_07083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="229" mass="25533" checksum="79FCB168F429BB58" modified="2017-10-25" version="1">MITLRNVTKSYKTSTRPALDNVSVEVDKGEFVFIIGPSGSGKSTFMQLLLKEVKPTTGEVHVADFRVDRLPGRRVPKLRQRIGCVFQDFRLLQQKTVEQNVAFALEVIGKNRKFINRAVPEALDLVGLSGKADRLPTELSGGEQQRVAIARAFVNRPLVLLADEPTGNLDPDTSQDIMMLLERINRTGTTVLMATHDNHIVDAMRRRVVELDRGRLVRDEATGVYGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWB1</accession>
    <name>A0A231GWB1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40920">
        <property type="protein sequence ID" value="OXR40920"/>
        <property type="gene ID" value="B7C42_07055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="27697" checksum="0D3A9E9E58EB228A" modified="2017-10-25" version="1">MTSDVVQHYSTASESDRLARSAHGRLELLRTQELIRRVLTSPAKILDVGGGTGVHARWLAADGHSVRLIDPVPEHISMAAALPGVLAEVGDARRLPVADHSVDAVLLLGPLYHLTEPADRTTALREAVRVLRPGGILIAAAISRYLSALECGANGTLDDTLIPSIREVISTGEYDGHVGFLRTHWHTADELRGEIEAAGLREVQIYGIEGPTWPALDRADPVDVPALMIAALRCARLLEQDPDIINTSAHLLAIARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD8</accession>
    <name>A0A231GWD8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative D,D-dipeptide transport system permease protein DdpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ddpC_2</name>
        <name evidence="6" type="ORF">B7C42_07017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40882">
        <property type="protein sequence ID" value="OXR40882"/>
        <property type="gene ID" value="B7C42_07017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="30872" checksum="46A80342AE7E83C3" modified="2017-10-25" version="1">MSARTHRPIAGTAGAAVLVVLVVLSLAAPLLSVHGPLDQDLGAVLRPPNAAHWFGTDELGRDVYARVLYGGRIGLTVTAIASVIAATLGLLLGLLGALFGGWVDGLAGRLADVQLAIPSIVLALVILSFVGNSLVPLVAVLVSGSWVLTFRVVRGHAQSIVRRPFIEAARLSGAGRWDIAVRHLLPGVLPLFTVAFTLNASAILLLESSLGFLGLGVQPPTPDWGSMVADGQARLDNAPWVALFPGAALILAIVGFQLTGDALSERFQGGVRGSGTRLLRAWRRPDVAPVREETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWP6</accession>
    <name>A0A231GWP6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41033">
        <property type="protein sequence ID" value="OXR41033"/>
        <property type="gene ID" value="B7C42_06803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013348196" evidence="1">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="125" mass="11839" checksum="027DFFA277E0BB0E" modified="2017-10-25" version="1">MLISRVLHTAAATLAITAGLAAGVAAAAPLPLEPVAPVAGTSGSADSATDGGAGSSVIDLLKLLGDISHGCTPGTVCAAAAATARTPEANTAIADTPLGSGSASGSNEPGSVLCWLLHPSPTCQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWU0</accession>
    <name>A0A231GWU0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase YcgJ</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycgJ_3</name>
        <name evidence="2" type="ORF">B7C42_06822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41052">
        <property type="protein sequence ID" value="OXR41052"/>
        <property type="gene ID" value="B7C42_06822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="29823" checksum="D46351C049E07C22" modified="2017-10-25" version="1">MTAIHHTQQSPVGLTERTHALWALGDYPRVADTVIPGLGRRLVRACDIRPGRRVLDIAAGAGNAAIPAAEAGADVIASDLTPEMFDAGRAAAAARGVHLTWETADAEALPYDDGRFDVAMSCVGIMFAPSHRAAADELLRVTAPKATIGLINWTPEGFIGEMFAIAKRFAPPPPPGAQSPLLWGTADHLRELFGDRVTDLHIEREFATVECFADGDRFRDFFKANYGPTVAVYKALAGDLDRIAELDRALADLAARHDLGGGRMRWEYLLVTARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWV6</accession>
    <name>A0A231GWV6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41100">
        <property type="protein sequence ID" value="OXR41100"/>
        <property type="gene ID" value="B7C42_06870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="14555" checksum="577A96E07CE1A1A3" modified="2017-10-25" version="1">MSESGRGTFAIGPHQPARQVIATFDDYADAESAGDSRSDQHFAVDEPAIDRHDIEQVVGRSNYRRAALRGAAAGGLIGAFFGWIFALGGRRDFTSTQPSQPRHYEVLADVEVADEPCACSPAGPIERNEPWRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX34</accession>
    <name>A0A231GX34_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine deaminase</fullName>
            <ecNumber evidence="5">3.5.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">guaD_2</name>
        <name evidence="5" type="ORF">B7C42_06734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41138">
        <property type="protein sequence ID" value="OXR41138"/>
        <property type="gene ID" value="B7C42_06734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="19664" checksum="DED268CFD2DD5F90" modified="2017-10-25" version="1">MDFAQRTIDLARRNVEEGGRPFATVIVKDGEILAESPNLVAQTSDPTAHAEILAIRQACTTLGTEHLTGTTIYILALPCPMCLGALYYCSPDEVVFLTTREAYAPHYVDDRKYFELNTFYDEFARPWDERRLPMRHEPRADAVDVYRRWQERNNGERRVAGAPTTAPRNTSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXB7</accession>
    <name>A0A231GXB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase 1</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG1_3</name>
        <name evidence="1" type="ORF">B7C42_06655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41257">
        <property type="protein sequence ID" value="OXR41257"/>
        <property type="gene ID" value="B7C42_06655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="27665" checksum="0CC55A8E7232DE5E" modified="2017-10-25" version="1">MNRLQGKVAIVTGTSPNIGGTLARGLAAQGARVLCTDLTAEVAEGCAAEIVAAGGDAAAIAGDVTDPDHADAAVAAAVERWGKVDILVGNAVFFHQQGLLTMGYADFRRQLDVILGGSFLFTRAVAKSMIETKTAGSIILVLSTAAWQGQPGNIGYSTGKSGLINFTRSAAMELAPHGIRVNGFTPTATAPNHPAARAQLDELLGAPGEYRMDFTGQLPLSRLPTPDDYVGAVVYLASDESSMVTGTNITVDGGATAKYWPWTPHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY08</accession>
    <name>A0A231GY08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase</fullName>
            <ecNumber evidence="4">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ndh_2</name>
        <name evidence="4" type="ORF">B7C42_06368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41476">
        <property type="protein sequence ID" value="OXR41476"/>
        <property type="gene ID" value="B7C42_06368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="41560" checksum="86F31CD81B86C6AF" modified="2017-10-25" version="1">MTNNEVLVIGGGYAGVMAANRLTQRDDVRVTVINPRQVFVPRLRLHQLVGATHDAVVDYPDVLAEQVRLVIDSVTRIDAARRTVQPAGGDSIGYDYLIYAVGSGIPAPQVPGAAEFAYPIATLEAAQRLRSVLFDTPSSAAVTVIGGGPTGIETAAELAGQGRAVTLVCGSVLGPYLHPKARRTAHKYLAKLGVTVVEGYGATVTAIGRDAVVLRDGRTLASAVTIWAAGFGVPDLAARSGLSVDAAGRLLTDETLTSVDDERIVAAGDSSAPSDLPFRMSAYTAYCLGAHAADTVLHRIAGEQPAAIDLAFPAMCLSFGRDAGIYQLGHKDETAMRLYFGGFAGKKLKEFACEAGIKHLATEARKPGSHHWFSDGKHRPAQLQARHDNTVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY90</accession>
    <name>A0A231GY90_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multidrug-efflux transporter 1 regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bmrR_2</name>
        <name evidence="4" type="ORF">B7C42_06234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783612.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41593">
        <property type="protein sequence ID" value="OXR41593"/>
        <property type="gene ID" value="B7C42_06234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="30389" checksum="136E15FAFFADD5A5" modified="2017-10-25" version="1">MFTIGDFARHGRVSVRMLRHYDAIGLLRPAHVDASSGYRSYQAAQLSRLNRIVALKDLGFTLQQVQTILDEDIGIEELRGMLRLRRAELEAALAEAMSGLARVEARLRMIENEDSMPQEDIVIRKLPPIRLAELSATATSFDPDETGPLIGRLFDELRRRLDSAAVAAGGPRTVYFETPDEDDYRIIVHVGLPVSAGVTEAAGLRIVSLPAVDRAATIVHRGMEHGFLRTSQLLVRWVEAHGYRFDGHAREITLNSSEDPDESVAELQAPIVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYC8</accession>
    <name>A0A231GYC8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biphenyl-2,3-diol 1,2-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bphC_2</name>
        <name evidence="9" type="ORF">B7C42_06240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.39" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41599">
        <property type="protein sequence ID" value="OXR41599"/>
        <property type="gene ID" value="B7C42_06240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018583">
        <property type="term" value="F:biphenyl-2,3-diol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 7 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="149"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="37785" checksum="F7AF0FC3F9C08E06" modified="2017-10-25" version="1">MIGANPDSVFGSVHLGYVVVQSNRHADWRRFGADAIGLHVDALDSGVLRFRLDDRACRFLIQRGPAEDVTALGWQIDDHETFDRIVARVSDRGVPITEGSAEEAALRGVQRLWRFPGPKGIAQEIFTVAVTMQEPLRMISSGWVTGEAGMGHVAIVSREPESMRGYYETVFDSRVSDYIDENISGLKMKIRFLRVNERHHSIAIADIRGIKIDPLRTRVQHINIQSATLDDMLAAFGRVTDLGFRMQWSVGQHTNDRELSFYCVTPSGFELEVGWNPIVIGPELESTWEPTTYPGISIWGHTPVGDTVLAKFTQFRRALQSVRTPEITVPQLTGGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ4</accession>
    <name>A0A231GYJ4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">drrB_9</name>
        <name evidence="10" type="ORF">B7C42_06286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41645">
        <property type="protein sequence ID" value="OXR41645"/>
        <property type="gene ID" value="B7C42_06286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="49"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="31976" checksum="CD8956BF854A6893" modified="2017-10-25" version="1">MSTVEAAVAESETAADPTQTDAAVTRPDIDKDVHTIAAPVRVFRDSAIIAYRNLLTILRVPTLLVTATVQPLMFVFLFAYIFGASLGGGQYREFLLAGIFTQTVAFNAAFTTVGLANDLQKGIIDRMRTLPMSRMAVLMGRTLSDTVVNVVALTVMVACGYLVGWRINGSVADAALGFAIILLFAFAMSWVGALTGLIAPNVEVAQSAGLIWLFPVTFISSAFISAETLPGPLRSIAEWNPITAVSASGRKLFANSSPPTFAAPHGWPVDHCVEYAVACSVAILAVAVPLALLQYRKVASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ15</accession>
    <name>A0A231GZ15_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isonitrile hydratase</fullName>
            <ecNumber evidence="2">4.2.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">inhA_3</name>
        <name evidence="2" type="ORF">B7C42_06195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41853">
        <property type="protein sequence ID" value="OXR41853"/>
        <property type="gene ID" value="B7C42_06195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050549">
        <property type="term" value="F:cyclohexyl-isocyanide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11002" checksum="955A76ECFD69E2F6" modified="2017-10-25" version="1">MHASNGMEVAAGAVTDCGDSDAVVIAGGDCLVERPVPAGLIAAVEQLRPRTRRMVSICTGSFALAAAGVLAGRRATTHWFGLSPSEYRARFGTADRRSRPAGTSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ77</accession>
    <name>A0A231GZ77_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779056.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41900">
        <property type="protein sequence ID" value="OXR41900"/>
        <property type="gene ID" value="B7C42_05884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="60"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16627" checksum="60E4D9099B98B82D" modified="2017-10-25" version="1">MSETPALDLPWGPADDGLDRPYWDGLVAGELRLQRCGHCGEWIWGPQWICASCHSFDPGWEPVEPVGTVYSWARSHYPFITELADRVPYVTVLVELPGAGNRRVLGLLVDEGADTVRIGDPVVGRIELDPGAIWPLLRWRRVDIEGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZM9</accession>
    <name>A0A231GZM9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042327.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42060">
        <property type="protein sequence ID" value="OXR42060"/>
        <property type="gene ID" value="B7C42_05659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="429" mass="45498" checksum="CB894A703D566410" modified="2017-10-25" version="1">MPTVTATGLGAGRYIAAGRRPSEATTTVHELETADGAKVRGVLTTVPGATTVVCLMHPRQDITHHPLVPGLLAAGAAVWTQHTRSVNNDLTLIHEQALLDVAAGMVFLRDRGFESIVTLGHSGGGTLYAYYLEQAGLAPEQRIAVTPGGRPSGLSEAEMPTADGAIFLAPHPGQGKLLLGCIDPSVTDEFDPMSVDPALNAFDPANGFAEPPHSSSYSAEFVERYRAAQLDRVRRIDDYARECLQRGAAARKRYATTRSAQDKREAIAPRIMTVYRTDADLRTVDLSLDPNDRPYGSVMGRRPDLINYGLVGFGRLTTPEAWLSTWSGISSNAEFARCAPGVRVPTLFIEVTGDQSAFPADTAQMVSALGAEDCTHIAARGTHFGGAITPGEPTGNVVAGAHAADWLEARFALAPIASGAEDEARDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZV2</accession>
    <name>A0A231GZV2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42143">
        <property type="protein sequence ID" value="OXR42143"/>
        <property type="gene ID" value="B7C42_05742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="7971" checksum="9088D44CF340DFCC" modified="2017-10-25" version="1">MRIVVDLNKCQGYAQCVPLAPRVLRLLGEEALTYDPNPDDEQRRRVLRAAASCPVQAILVETHTPDDAEPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0N2</accession>
    <name>A0A231H0N2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hercynine oxygenase</fullName>
            <ecNumber evidence="1">1.14.99.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">egtB</name>
        <name evidence="4" type="ORF">B7C42_05603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O</text>
            <dbReference type="Rhea" id="RHEA:42672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="EC" id="1.14.99.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EgtB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.50" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42402">
        <property type="protein sequence ID" value="OXR42402"/>
        <property type="gene ID" value="B7C42_05603"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044875">
        <property type="term" value="F:gamma-glutamyl hercynylcysteine sulfoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02035">
        <property type="entry name" value="EgtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032890">
        <property type="entry name" value="EgtB_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Gamma-glutamylcysteine binding" evidence="1">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="445" mass="49645" checksum="6C30AE96630C5C30" modified="2017-10-25" version="1">MTVHTGTDHAATERLRAQIAEVLIRARARTTVLTEAVDEADLVAQHSPLMSPLVWDLAHIGNQEELWLVRDVGGREPVRADIDHLYDAFRHARADRPALPLLDPAQARGYVGTVRDKVLDVLNSSPLRGNRLVDSGFAFGMIAQHEQQHDETMLATHQLRTGAAVLTAAPAPAARVAVGDEVVIPAGEFTMGTSSGPWALDNERPEHRVHVPGFAIDAAPVTNAQYLAFIEDGGYHRPELWSQRGWAHRVEADLTAPQFWERDSDNRWWRRVFGSPAQVRPQQPVVHVCWFEAEAYANWAGKRLPTEAEWEKAARFDPATGRSRRYPWGDAEPDDTTANLGQRHLEPADVGAYPAGASPGGVHQLIGDVWEWTASGFEPYPGFAAFPYREYSEVFFGGDYRVLRGGSFGTDPVACRSTFRNWDHPIRRQIFSGFRLARDLRPDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0P1</accession>
    <name>A0A231H0P1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cass2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780726.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42440">
        <property type="protein sequence ID" value="OXR42440"/>
        <property type="gene ID" value="B7C42_05641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cass2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="16235" checksum="4F1986A3E4A61520" modified="2017-10-25" version="1">MTYSIVVRDAAIYGGLVVPRVRPSFKVSNSELIEFLRDRLRDREIGGPLYTVYVPDPAGNYNVLVSYEYHAPKEVPVGDVMICVPKGVYARFEPNGDYHDPVEDVWAQVDDATASAEITRAYREEIEVWRGPDRLELFISILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0R1</accession>
    <name>A0A231H0R1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor YtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytrA</name>
        <name evidence="2" type="ORF">B7C42_05634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42433">
        <property type="protein sequence ID" value="OXR42433"/>
        <property type="gene ID" value="B7C42_05634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="12857" checksum="23418ACB846DB971" modified="2017-10-25" version="1">MLDIPVDHQSTVPPYEQLRLGIVARVRSGELTAGTKIPTVRALAVQLGLAPNTVARAYRELEQDGVLETRGRLGSFIASSGDPTRDAAGRAATEYVAAVRRLGLDDEAALSYVRAALGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1E4</accession>
    <name>A0A231H1E4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42669">
        <property type="protein sequence ID" value="OXR42669"/>
        <property type="gene ID" value="B7C42_05447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="17416" checksum="E2C783F9ACB558F7" modified="2017-10-25" version="1">MSHNRFLRLAPGEVRPGRVPMPPAFAVKATTADTEGRFSLLEVTLARDIPRHTHEVADESIYVLSGELGVDFDDRSFVAPAGTFVLLPQGIPHALRAVSDPPPTVLQISSPGGWECYLEDLFEAGATVLTDGALDPRKINPIAAAHNIRYDEHRTPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1K6</accession>
    <name>A0A231H1K6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42728">
        <property type="protein sequence ID" value="OXR42728"/>
        <property type="gene ID" value="B7C42_05065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="361" mass="37199" checksum="814C7BBF2805E724" modified="2017-10-25" version="1">MLHKLLGSRAFMSIAGTVAVVAVAVVGYLVAFQPLKATTAYCAIMPDSVGLYPGNQVTMRGITVGTVKSVAVQGNAVKVEFDVDSDHPILADAGATTLSDSIVASRELAVVSGGKETARWDPAHCLTRTLTPKSISDTLNALAQLSSQIQGPDAAHPDALERGLTSLNDATAGTGPQINALVQKLGAALSAPDADIAHLAGIFDAFASVSKDVEAHWGELKTMLTRLGPVLDQATEDLLRPGAALFDGLGQVLPMLNDITTLFGDPIMRALDDTVPLVKFLRANVGSLAQMISLTPVLAQAVHTVGDSGIGYAPPKVAIAQDHADQVCAAIDTLAPGRCTPADGLAKVDMAALIFGLAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1V8</accession>
    <name>A0A231H1V8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">nasD</name>
        <name evidence="19" type="ORF">B7C42_05167</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42829">
        <property type="protein sequence ID" value="OXR42829"/>
        <property type="gene ID" value="B7C42_05167"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="17">
        <location>
            <begin position="12"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="18">
        <location>
            <begin position="330"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="16">
        <location>
            <begin position="427"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="15">
        <location>
            <begin position="559"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="14">
        <location>
            <begin position="631"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="832"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXR42829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="872" mass="91423" checksum="E9A3648740B88E40" modified="2017-10-25" version="1">MNTTVEPTQRKTVVVVGHGMVGHRFVEALRSRDEAGHWQIVVLSEESQAAYDRVGLSSYVGAWDKSALALPGNDYAGDALVDLRLGVRADEIDRAARKVTTSSGDVIGYDALVLATGSYAFVPPVPGHDRPECFVYRTLEDLDGIRAAAQNAGPGAVGVVVGGGLLGLEAANAVRLMGMTPHVVEFAPRLMPVQVDEGGGAILEKLVTDLGLHVHTGVGTSAIEPAEDGAGLRVSLSDESVIDASLVVFSAGVRPRDQIARDAGLEIGPRGGALTDLGMVTSDPHIYAVGEVAAVEGTCYGLVAPGYTTAEIVADRLVGGAGEFPGADLSTKLKLLGVDVASFGDAHATTEGALSVVLHDAAKGTYAKLVISDDAKTLLGGILVGDASQYAALRPLVGSELPAEPAALISPAGAELGADALPDEAQICSCNNVSKGAIVGAVHEGACDIAGVKSCTSAGTSCGGCVPMIKKLLEQSGVEMSKALCEHFTQSRSELFEIVQVTGIRTFSELIAKHGTGIGCDICKPTVASILASTSSDHILDGEQSALQDTNDHFLANLQKNGTYSVVPRMPGGEVTPEQLIEIGQIAKDFGLYVKVTGGQRIDLFGARVEQLPQIWQRLVDKGMESGHAYGKSLRTVKSCVGSTWCRYGQQDSVGMAVLLEKRYRGLRSPHKLKLAVSGCARECAEARGKDVGVIATENGWNLYVGGNGGLTPKHAVLLAGDLDDETLIRYIDRYLMFYIRTADRLQRTAPWQEALEGGIEHLKQVVCEDSLGIAADLEASMARHVAGYKDEWAAVLEDPAKLSRFVTFVNAPEEADPTIAFDESGERKTPVLLGLPEMPGGGSLRNHGGHRAGRDGHSLPAVPAATATPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1X3</accession>
    <name>A0A231H1X3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine monooxygenase RutA</fullName>
            <ecNumber evidence="2">1.14.99.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rutA_4</name>
        <name evidence="2" type="ORF">B7C42_05176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.46" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42838">
        <property type="protein sequence ID" value="OXR42838"/>
        <property type="gene ID" value="B7C42_05176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="32149" checksum="1B43B245C46E6C34" modified="2017-10-25" version="1">MAVMRFHFAEAGGDPVHWVDLARAAERAGFTGICLADSLAYPRDGDPRYPYTADGRREFLRGKPFAEPMIAATAITTATTTLRVTPFVLKLPVRPPVLVAKQAATLAVLSGDRLSLGVGISPWPQDFTMMGVPFERRGARLDEGIDIVRGLCGGGEFAYRGQIYDLPAVEITPVPATPIPILVGGHSEAALRRAVRRGDGWMHAGGDLGELATLLSRLAELRSEYETSASARTSEFQIHVVARDPFDTDAITQLAASGVTDVIVGFRSIYDATPDTRSLAEKVETITRYGETVVAAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1X9</accession>
    <name>A0A231H1X9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atsA_4</name>
        <name evidence="6" type="ORF">B7C42_05198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42860">
        <property type="protein sequence ID" value="OXR42860"/>
        <property type="gene ID" value="B7C42_05198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="765" mass="84901" checksum="96A988387F4A951B" modified="2017-10-25" version="1">MPVPEYARGYDAFTGEIGRTTAESTPAWDRPPSAPAGAPNIIVVLVDDMGYSDIGPFGSEIETPTLNRLAERGVRLTNYHTTPLCSPSRAALLTGLNSHRAGFGFVANADPGYPGLRLELADDVLTLPEILRAGGYATYAVGKWHLVRDATMNPAAHRDSWPTQRGFDRYYGSLEGFNSFFYPNQIVSDSSVVDIEQYPEDYYVTDDLTDKAITYLKDLRAHDADKPFFLYFAHVAMHGPLQAKDADLAKYRGRYAQGWDAVRQSRFASQLAQGLFAPGTEQQPRNTEPGYEAQEWDSLSTEQQRRFARYMEVYAAMVDSIDQSLGRVLDTVEQFGELDNTIVVFTSDNGGTAEGGPVGTRSYLAEFAHVEDPDWVGDVPHDEDLIGTARLGVHYPRGWGQASNTPFRFYKGQTFAGGVRVPFIISWPKGLPDNAIRDEYVYVTDLAPTLLELSGVSRPSVRHGLPAKDFDGVSAAPVLRDLDARSRHVEQYSEMTGHRGFYRDGWKLLALHEPGGEVDAPNWQLFDVRTDPTELHDVAAEFPGKVRELAAAWDEAAWRNTVFPLLTRRDLARRRPEEARLSEPLRILPGTPTLERYRSQRLIAYRDFTVTAALAGYHDGDEGVLVAHGDPQGGYLLYIEHSRIVFGFNSFGRYTEVSARIAPGTREVTLAATVRPRLRWDFALSLDGTSVATLTDQVQLVGMAPWTGISVGVDARGPVAWDLRQRRGPFRYTGSLRAVTYTPGPLQVPEQVVRAVESEAELVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H319</accession>
    <name>A0A231H319_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43273">
        <property type="protein sequence ID" value="OXR43273"/>
        <property type="gene ID" value="B7C42_04695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23584" checksum="5E4DFF996CBD2609" modified="2017-10-25" version="1">MTKPMRIAGIAIPDSRVVAEATDLVRGIAPALLFHHSRRVYLFGMLQGQLRGLEPDPELLYVGAMFHDLGLTDAYRTEDRRFEVDGADEARRLLLEHGIEPEAAQRVWTAIALHTTPGIPEHMEPEIALVTAGVETDVLGIGYHGLAPADIEAVTDAHPRPDFKRQILAAFTKGFADRPDTTFGTVNADVLAHFVPGFVRTDFVDVIESNPWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H321</accession>
    <name>A0A231H321_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor YvoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_3</name>
        <name evidence="2" type="ORF">B7C42_04677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43255">
        <property type="protein sequence ID" value="OXR43255"/>
        <property type="gene ID" value="B7C42_04677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="27188" checksum="02860B35038A2113" modified="2017-10-25" version="1">MRRDRVESEPAYRAVARSVRAEIAAGRYAGGVALPTEMELAQRHRVSRHTVRRAFQDLVAAGEVYRVAGRGTFATGAEQRYLRQFGSIEDLMQLSSDTTMQVRSGLRRRVDIEAASRLRLDTDVVYTVVFVRLHDGVPFVCTTVHLPEAIARSVAAAPELADGASSPYTVIGLLEPHLNSPIVEAAQSITVAAATPATAAELGCAPGHSMLRVDRLYSDAGGAAVELSVSQFLPEHYTYRVTLRRSGVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H343</accession>
    <name>A0A231H343_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzene 1,2-dioxygenase subunit beta</fullName>
            <ecNumber evidence="2">1.14.12.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bedC2</name>
        <name evidence="2" type="ORF">B7C42_04660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43238">
        <property type="protein sequence ID" value="OXR43238"/>
        <property type="gene ID" value="B7C42_04660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018619">
        <property type="term" value="F:benzene 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="19573" checksum="6A7EE2A19B812CB3" modified="2017-10-25" version="1">MTTAQTSADTSIAAPQPLRVPDPDIEGFLYLEARLADEARYSEWEALWADDALYWVPMRPEDDPAVNLAYIHDNRRRIKSRVAQLNTGHRHSQTPPSVMRRMLANMEVTDESDGVVTVASNFALFEYRYTQRIWAGRVVHRIRRTEEGLRLVAKTVHLVNAAGPVETLAFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H397</accession>
    <name>A0A231H397_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gpx1_2</name>
        <name evidence="6" type="ORF">B7C42_04746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009513.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43324">
        <property type="protein sequence ID" value="OXR43324"/>
        <property type="gene ID" value="B7C42_04746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19541" checksum="F9B3F59689C14766" modified="2017-10-25" version="1">MAFHEFSVATADGGSRSLEEYAGRVVLVVNVASKCGFTPQYEGLEALYKKNRDRGLEILGFPCNQFGDQEPGADAEIQEFCSTNYGVTFPVFGKIEVNGPGADPLYTYLRAEAPGDFGPSAGRLYDHVKATRPEAIGTDEVKWNFTKFLVGRDGTVIRRFESTVTPEQIESEIADLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3G5</accession>
    <name>A0A231H3G5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase 2</fullName>
            <ecNumber evidence="4">4.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prpD2</name>
        <name evidence="4" type="ORF">B7C42_04245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.79" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43378">
        <property type="protein sequence ID" value="OXR43378"/>
        <property type="gene ID" value="B7C42_04245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="284"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="501" mass="54388" checksum="156528A4D20336E5" modified="2017-10-25" version="1">MKNHLVRTHRSAEVFPRTEHLAWRIAEVATDPVAVAPDTEEMIVNRIIDNAAVAAASIIRRPVAGARAQALAHPYRPGSSVFAVPGTYSPEWAAWANGVAVRELDFHDTFLAAEYSHPGDNIPPILAAAQHAGRSGRDLVRGLATGYEIQIDLVRAICLHEHKIDHVAHLGPSAAAGIGTALGLDTETIYQAIGQALHTTTATRQSRKGEISSWKAYAPAFAGKMAVEAVDRAMRGEGAPAPIWEGEDGVIARLLSGPDAEYSVPLPGPGEPKRAILDSYTKEHSAEYQSQAPIDLARRMRDRIGDLDRVASIVLHTSHHTHVVIGTGSGDPQKFDPEASRETLDHSVMYIFAVALQDGTWHHERSYAPERARRADTVALWHKISTAEDPEWTRRYHATDPAEKAFGARAEVTLTSGEVIVDELAVADAHPLGARPFAREQYITKFRTLAEGVVDAAEQDRFLDAAQRADSLAPGELAQLTFAVSDEVLGRAPKSPKGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3K4</accession>
    <name>A0A231H3K4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43437">
        <property type="protein sequence ID" value="OXR43437"/>
        <property type="gene ID" value="B7C42_04304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="21685" checksum="68D8FFC05BF53A49" modified="2017-10-25" version="1">MFVGMHWDQMTATTEELRKRATRLRRGVGQLGILESILSAAHGPWLGAMDADGRGTAELRMHLAGRYRVTAVVTSAGKLSMIQLHAPTPDGGDSERVLSPKPALRRGWHDDEPMPKQPQWLDYLVEWVGSASTDVDRRSVLEWHLEGADRRLAAMNETIESLRLSLAEREELRDEVAAEVGRLRAELDSLDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Q7</accession>
    <name>A0A231H3Q7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779282.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43484">
        <property type="protein sequence ID" value="OXR43484"/>
        <property type="gene ID" value="B7C42_04351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="497" mass="55490" checksum="002DFCEEB2B6C6DE" modified="2017-10-25" version="1">MAPQYDAVVVGAGFGGMGAGIQLDRLGLKNFVILEREDGLGGTWHVNHYPGLAVDIASVTYSYSFAPNPHWSRLFAPGAELKKYAEHIADTYDLRRRMRFNQVVGGARWDSEHAHWVVSVEGGRTLTARYLLTATGFLSQPYTPPFPGIDSFAGKIIHTTAWEDDFDLTGRRAAVIGTGATAVQLVPEAAKKVAELTVFQRTPIWVVPKVDTAIPKPVQQLFEKLPLTQKAARLVNTGALELLMVSGVLHYKQAKFGNKGAALLAKAHLRAQVRDKQTRDKLTPHYDFGCKRPTFSNTYFKTFNEPHVRLETNAIDHVEADGIVTADGHKTEIDTLILATGFNLWDVNFPAVEIIGRDGVNLGKFWRDNRFQAYEGITVPKFPNFFSLNSPYSYSGLSYFTTIEAQMKHMDRLLREARRRGEQVFEVREEANARFLEYVTEKLGSSVFYAGDCSTARSYYFNQHGEAALLRPNSTITTHREAVNFPLDDYVYGAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4F4</accession>
    <name>A0A231H4F4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43717">
        <property type="protein sequence ID" value="OXR43717"/>
        <property type="gene ID" value="B7C42_03952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="56" mass="6026" checksum="8CA3B4C0C84E9A7A" modified="2017-10-25" version="1">MSGGEVTRRRQVAAGFTSPPPAWGDCLSQWNWPSSVEPFRAAVEVFGSTVVAMVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4N4</accession>
    <name>A0A231H4N4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781183.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43790">
        <property type="protein sequence ID" value="OXR43790"/>
        <property type="gene ID" value="B7C42_04025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="89" mass="10087" checksum="4984AA794B6118E6" modified="2017-10-25" version="1">MPTAPTIIDPYAPLLKQPLPAGRPRSWYVMHNRRLKAMRLAIALLDSGVYRANLADNQTIRHTAEVVGIRPPSNKTCSLVRDLMRVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4S9</accession>
    <name>A0A231H4S9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781142.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43840">
        <property type="protein sequence ID" value="OXR43840"/>
        <property type="gene ID" value="B7C42_04075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7350" checksum="89CAF2D987A7006D" modified="2017-10-25" version="1">MTDPTIDTTSVDMVPEADQLDQNLEVAPDEPEFDAPAVDREAAEADLIEQSIPVPLDDEYDEPEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H525</accession>
    <name>A0A231H525_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43955">
        <property type="protein sequence ID" value="OXR43955"/>
        <property type="gene ID" value="B7C42_04194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="35610" checksum="F45F7EF2A1165413" modified="2017-10-25" version="1">MFVALRDLRAARGRFLLITLVVTMVALLVSFLSGLTAGLAHQNISALERLSGGSVVFADTGADPSFDSSALTGEQVQRWQRAGGTVDPVGISRSQAVRDGSAPAQVAIFGVDGTAFGNEVVTPPGTVVLSKAAAEDLSATAGARVSIGDRTFTVAGIGGDDWYAHTPVVWTTLSDWRQLDPRGGAATILVASGVPGTDVVNSAAHTRTTSVEGALRAIGSYRAENGSLTLMTVMLFVISALVIGAFFTVWTIQRTPDIATLKALGATTTALVRDALGQALIVLLLGVGAGVGVTALAGVFLGAAVPFVLSAATTVVPALALIGLGLLGAVFALRFLVTTDPLTALNNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H581</accession>
    <name>A0A231H581_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44059">
        <property type="protein sequence ID" value="OXR44059"/>
        <property type="gene ID" value="B7C42_03615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="25594" checksum="C606EB3CAB87B47B" modified="2017-10-25" version="1">MPSNSLVGVKFLRRGDASTTDDHVDDTSAATDDDTATAAQRPAPTAGKGRPTPRRRDVQGRRRGPVAPAPLTAKEARARRKATRGNREERKVASAERRAAAADRRARMLAGEDKYLLPRDRGPVRAYVRDLVDARRNLVGLFMPLALVLILTMFLTPQVQAYVTLAMIVMMLFMVAEGFVIGRLINKRVHERYPDDTTSSWSLGWYAFVRASQIRRMRAPKPRVSPGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5A8</accession>
    <name>A0A231H5A8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR43998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783872.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43998">
        <property type="protein sequence ID" value="OXR43998"/>
        <property type="gene ID" value="B7C42_03554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="12153" checksum="EBCAE638DC7EC6CC" modified="2017-10-25" version="1">MTELPTPLTDSEIAVRLEALPGWARDGDEITRTFAHTYHECVHLAVYVAAKAREVGHHPDMLITWQRIEFRITTHDVGRKLTALDFELARDIDRIAEAAGATSADETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5D0</accession>
    <name>A0A231H5D0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44037">
        <property type="protein sequence ID" value="OXR44037"/>
        <property type="gene ID" value="B7C42_03593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9124" checksum="D7F8FF089FEDBD72" modified="2017-10-25" version="1">MKDGAGQQKTFAGRSVPVHLARGLLGFGLIAGSIALIPAAGPAALLLLPAGVVALRGCPTCWLIGLAQTVSRGRIERECTEGRCRMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5F7</accession>
    <name>A0A231H5F7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione transport system permease protein GsiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiD_2</name>
        <name evidence="6" type="ORF">B7C42_03753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44193">
        <property type="protein sequence ID" value="OXR44193"/>
        <property type="gene ID" value="B7C42_03753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="101"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="31243" checksum="95BA058B7064847A" modified="2017-10-25" version="1">MTTTTDAAADIDEERHDVVATLAVTRSRRRPAMPGLRDLATVAAVLVVAVLTAWAIAPGLFTGHDPYAGVTADNFRAPSWEHLFGTDQFGRDILARVVFGTRTAVLTALLAVGIGLVAGSAVGLIAGFSGRVADAILGRLIDALLAIPGFLLAVVVVVSLGFASVNAAVAVGISSVAVFARLIRSETLRVKNTAFIESSRLIGGGKIVVLCRHVLPNVYRSVLALAVLQFGLAIINISALAFLGYGNPPPSPDWGLLVADGKDFFYRYPWFVYGPGLVIVLSVLSLGQLSKLIGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5L8</accession>
    <name>A0A231H5L8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44097">
        <property type="protein sequence ID" value="OXR44097"/>
        <property type="gene ID" value="B7C42_03653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="35219" checksum="75477E30B2BBBD43" modified="2017-10-25" version="1">MSGLLRVRTWLAHRGRFEFVATLAVVVALTAAGGALLMLPKTGLHTVPAAEESDTAPAHADPQLPELRRVMSSYGPVVAQQVSGDDGKLSVVLGHPYQRGDVDQLAREVGPAVTAVSEVWGTEWAHEAVVAVASSSSEFAALTHATGSVSGEVAAASVSDPFVPGTQPAGQRIVFAPDAGRRLGPDGLRETLRHELTHIAARARTVDGSPQWVLEGFAEYCGHRGDQQRFAQVAPTVTTRARSGDLPADLPGDTAFAPSPGIDAALAYEQAWSANAFVADRFGEPKLVALYRRLATGPQDQAALDRGLRDTLGLGHTDFVSAWRDWIKARVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H665</accession>
    <name>A0A231H665_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="5">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lcfB_13</name>
        <name evidence="5" type="ORF">B7C42_03881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44320">
        <property type="protein sequence ID" value="OXR44320"/>
        <property type="gene ID" value="B7C42_03881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="449"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="981" mass="105153" checksum="35B0179D0762B91C" modified="2017-10-25" version="1">MKFDTRTLTGPARRLMATAQNGLEVIRFGGLAHDVESSPFEVTERKRMYRLRHYFPDDPAADRPVALLVPPLMVNADIYDVNAEGGAVGILHRAGIDCWVLDFGSPATEEGGWQRDLADHVLALSSAIDTVNELTGRGVHLMGYSQGGMFAYQATAFRYGKGVQSIVTFGSPVDIVAGLPFGLPYGLVSEVADFVADHVLTRLPITDAMVRVGFQLLDPVKTAKARIDFLRQLHDREALLPKERQRRFLEHDGWVGYSGPAAADLLKQFVAHNRMMSGGFVIRDQPISLAEVKCPILAFVGEVDDIGQPAAVRGIVRAAPNAEVYEATLVAGHFGLVAGSTATNQTWPLVRDWVNWLGGHAELPEQIAPMREHVAADRQSTAATRVVHTAATLAEAGAGIGAAFGSLAGNALRGSKELTGEAARALPRLTRLGMIQPHTRISLGRLLAEQQRSAPMRELFLFDDRVHTHAAVGARIDNVVRGLISAGVRPGTRVGVLMETRPSALASVAALSRIGAVAVLLAPGGDTARAVESTGTTVIVSDPENLRAAAAAGTRVLVLGGGNARTLDIPDGADVVDLEQVDPAAVALPGWFRPDPGVARELAFILVTGTGDKLDLKYITNHRWALSAFGTASAADLDRRDTVYCLAPLHHSSGLLVSLGGAVAGGSRIALARSLDPPSFAAEVHRYGVTVVTYTWTMLRDILDADTFPAGHSHPIRLFIGSGMPAGLWRRTTERFAPARVLEFYASIEGDVVLANVAGVKIGCKGRPVPGTAKVELISYDPIAEQIITDTRGFARRAADNEVGLLIGRAADTVDISRGGLRGVFSAGDAWMPTENLFRRDSDGDYWLMDRRDTVIATARGPVYTQPIVDALNDIAAIDMEVAFGRRTPSTTLAVAVVSVRAGHRLEPADVTEGLRALDPAQRPDVVQVVDEIPRSSSFRPATHAVRSALRLEPNENTWYYNREAEGYEVLTPEVAAALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H711</accession>
    <name>A0A231H711_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775964.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44537">
        <property type="protein sequence ID" value="OXR44537"/>
        <property type="gene ID" value="B7C42_03326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15346" checksum="BF4A50DDF0430033" modified="2017-10-25" version="1">MPSKMIFINLPVENLERSTSFYEALGWKVNPDFTDENAACVVVDDNICLMLLVRQYFDTFTNRPIADTRAATGSIYALSLGSRAEVESLIAAAVGAGATEEVSEDKRAQEEAVGMFSRAFVDPDGHHWEGFWMDYPGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H781</accession>
    <name>A0A231H781_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44708">
        <property type="protein sequence ID" value="OXR44708"/>
        <property type="gene ID" value="B7C42_03502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="10031" checksum="477635F36BB03FD6" modified="2017-10-25" version="1">MAETRADADDEPFGPVRPSDAVDGWELAGDGTRWWLVKAFGDARALVKPTTRTTCAWRVEAADGRMVREVSARSVAEAKIAAEEWIRRTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Q6</accession>
    <name>A0A231H7Q6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44878">
        <property type="protein sequence ID" value="OXR44878"/>
        <property type="gene ID" value="B7C42_02832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="490" mass="54196" checksum="502165AB73CFCC47" modified="2017-10-25" version="1">MRCVVFGATGYIGGRLVPELLAAGHQVRVLARTPAKLDDAAWRDSVEVLRGDVLRAEDVAAACAEADVLYYLVHSLTRTDFDDVDRRAATLVAEQAARAGVRRIVYLGGIVPPGQRLSRHLSSRAEVGRILLAGSVPAIAMQAAVIIGSGSASFEMLRYLTERLPVMVTPRWVRNRIQPIAVRDVLYYLTRAAQLPPDVRGAFDIGGPDVLTYEQMMRDYAEVARLPRRVIVPVPVLTPWLSAQWVNLVTPVPKAIAVPLMESLVNDVVCEDHAIAEHIPDPARGLIGYRTAVELALTRIRDLDVPTRWSDADQLGREPSSPLPTDPAWSGGSLYVDVRERHTRADPATLWAVIESIGGEYGWYSFPLAWSLRGWIDRLAGGAGLRRGRRDPHRLHAGEALDWWRVERIERPRTLVLRAEMRVPGRAWLELSVDTDARGTVYRQRAVFDPHGLAGHLYWKAIAPFHALIFGGMTRNITGAAEEAVSQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H864</accession>
    <name>A0A231H864_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780057.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45124">
        <property type="protein sequence ID" value="OXR45124"/>
        <property type="gene ID" value="B7C42_03081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="8639" checksum="35005E0F5AFEB57C" modified="2017-10-25" version="1">MPSETIHPDGASGRRSIAAVRSREILNYFGKCQACGYPAQAVLRTTLYSDGTITDAVIATCASPCGWSGTSAPTVMTVRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H874</accession>
    <name>A0A231H874_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45071">
        <property type="protein sequence ID" value="OXR45071"/>
        <property type="gene ID" value="B7C42_03028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="10848" checksum="461ABFDF18DE2B86" modified="2017-10-25" version="1">MTMKVVALRSIPIAGWLFLLAGAAVRDSGRRWLRTLWWIDAVLSIGVHAAQIPVALRAARGSGRSRLYTAVMTQLFGLTWWRTETVCGTASFEEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8W3</accession>
    <name>A0A231H8W3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45242">
        <property type="protein sequence ID" value="OXR45242"/>
        <property type="gene ID" value="B7C42_02367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="30438" checksum="175FF8CBB93A3136" modified="2017-10-25" version="1">MSTASLDRTELTSALSDQWDALAELTGGLDEDRWRLPSPLPGWTVFDVLAHVVGTESMLLGEPLPQVDSDFSAFGHVRNDTGALNETWLESLRPLRGDELLRRFTEVTGRRRAALAAVDEAAWAADIQSPIGVVSYGRFMRVRLFDCWMHQLDITDALGGEAKALGMDEGGRRAEIALDEIEPFLGRVVVKRGGAPDRSRITIETTGPVARTVHIRVDGRAEVVAALDRPADTVIRLGSGLFARLCGGRTAAADHRDEIEVDGDRELGERIAVNLAFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H954</accession>
    <name>A0A231H954_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45332">
        <property type="protein sequence ID" value="OXR45332"/>
        <property type="gene ID" value="B7C42_02457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013348218" evidence="1">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="14550" checksum="24B15D072D057BAF" modified="2017-10-25" version="1">MNTRWSPVLAAALIGIVSAFTLGAGSAHADAERQDGPVTLYVSGEGLIVYKVVTTLAVAHGSSGNLQAYYLIVPPGGNAAKAEKKYSEHVFEGPLRPGVARDSYGPTGGFLDGTQLCAGWWDPLGHLTIPGYPCVRIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H984</accession>
    <name>A0A231H984_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ORF">B7C42_02382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45257">
        <property type="protein sequence ID" value="OXR45257"/>
        <property type="gene ID" value="B7C42_02382"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="105"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="41527" checksum="461D8512B5612B2F" modified="2017-10-25" version="1">MPTVAMIGGGQLARMTHQAAVALGQCLRVLAERPDDPAAQVSPEVVLGSHTDLAALRKVAVGTHAVTFDHEHVPTEHLLALVAEGVNVQPPPAALVYAQDKLAMRRKLAGMGVPVPAFTAVETVADATGFLAEHGPFVLKAVRGGYDGRGVWMIDDAAEAERIVTDQLGHGVTLLAEQRVDLKRELSAMVARSPFGQAAAWPVVETVQREGQCAVVIAPAPQLSDEAATEAESLALRLAAELGVTGAMAVELFETHAGDLLVNELAMRPHNSGHWGMDGAVTGQFEQHLRAVLDYPLGATTPLAPVTVMANILGAAEAPSMSMDERLHHLFARIPEAKVHLYGKGERPKRKIGHVNILGDDVAEVREKAERAAHWMSHAVWTDGWDPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H998</accession>
    <name>A0A231H998_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45524">
        <property type="protein sequence ID" value="OXR45524"/>
        <property type="gene ID" value="B7C42_02649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5927" checksum="EBD6662553530615" modified="2017-10-25" version="1">MNDIWIFAATALGIVVIVSVAVWCWPTRIPKGRSVDEIRQRIEDEDDRTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9G9</accession>
    <name>A0A231H9G9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45376">
        <property type="protein sequence ID" value="OXR45376"/>
        <property type="gene ID" value="B7C42_02501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035165">
        <property type="entry name" value="DUF5319"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17252">
        <property type="entry name" value="DUF5319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20380" checksum="308412F263E6CDDD" modified="2017-10-25" version="1">MLPGACVSMVSAACGGDLVASDTVVDEGDSRATSASKCLQRWRGGGGSAYRGIVRDHLPPGLPPDPFAGDPSDPSAALDAIEPGEPLDPHERLAVEEDLADLAVYEALLSHRGIRGLVVSCEDCRQDHYHDWDMLRANLLQLLVDGTVRPHEPAYDPTPEAYVTWDYCRGYADASMNEALHGDGFDGFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9I5</accession>
    <name>A0A231H9I5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45509">
        <property type="protein sequence ID" value="OXR45509"/>
        <property type="gene ID" value="B7C42_02634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012579123" evidence="2">
        <location>
            <begin position="35"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="438" mass="45367" checksum="6481FE416BF3ABBF" modified="2017-10-25" version="1">MRGLIRRWNAVLFGSLVVIAGAAISAPPASPQPAAEVAADDFYMPPPVPPMPPGAILRAQPAALVMSAPGRPGVVPAASTRMMYISSDTHDAPTAVVATYLQPTLPWTGPGERPLVAYGVGSQGQGDQCAPSKVLPQLAQFQPPYDLIAEYDVIALTSLLARGMAVVLTDYHGLGTPDVHDFLNRKAQAYAVLDSARAALQLPGTGLNPNSPVILFGYSQGGMASAGAAELQSKYAPELNVRGAYIGGPIVDPESFIGYNYGQHGVGSSAPFTLNGIAADYPETRPILDAEINDAGKGLMNDALGKCAIAASVDIQIRRITQITNSGEPLTAVIDRSPALKAAFDEQRIGTMAPSMPVLIASAANDEGTPYPPVRAVAAGWCAGGTPVQLDANPQLPAVTGVVGTHDLAYFPSLMTANSWMTDRLAGLPAPSNCAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9J1</accession>
    <name>A0A231H9J1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azoB_3</name>
        <name evidence="2" type="ORF">B7C42_02625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776500.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45500">
        <property type="protein sequence ID" value="OXR45500"/>
        <property type="gene ID" value="B7C42_02625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="29748" checksum="089015779F737EB8" modified="2017-10-25" version="1">MVTVVFGARGNVGRHVAAGLIAAGEKIRVTSRRPGDASFTPEVEVVAADLERPETFPAALDGARRVFLYAKPAGIDGFVAAAEAAGVRQVVLLSSGAVLHADTGNPIARDHLAVESAIEKSGLPWTFIRPGMFATNTLWWWRTSIRDEGVVRVPYPEARTAPIHEKDLASLAVTALTEPGHEGRAYPVYGPEAVTVREQVEQIGAALGRDIALEVISPERARIELGKTMPPVGVEAILGGWRAGTVTPPQISTVIADITGRPARTFAQWAADHRDDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9M0</accession>
    <name>A0A231H9M0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplC</name>
        <name evidence="8" type="ORF">B7C42_02680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776442.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45555">
        <property type="protein sequence ID" value="OXR45555"/>
        <property type="gene ID" value="B7C42_02680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23143" checksum="3B6D233335AF6E67" modified="2017-10-25" version="1">MTDNKNRPAAGILGTKLGMTQVFDEKNRVVPVTVVKAGPNVVTQIRTEERDGYSAVQIAFGAIDPRKVIKPVAGQFAKAGVTPRRHIAEIRVADAGSFEVGQELSADVFEEGTYVDVTGTSKGKGYAGVMKRHGFKGQGAAHGAQAVHRRPGSIGGCSTPGRVFKGMRMAGRMGNDRVTTQNLSVHKVDAENGLLLIKGAIPGRKGGIVIVKSAAKGGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAD2</accession>
    <name>A0A231HAD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitinyl-CoA dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">caiD_3</name>
        <name evidence="2" type="ORF">B7C42_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.149" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45808">
        <property type="protein sequence ID" value="OXR45808"/>
        <property type="gene ID" value="B7C42_02100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="28451" checksum="1138E7404D7B2F96" modified="2017-10-25" version="1">MSTSTTSETTAPETGQVVVERRDAVLVVRINRPQARNALNGRVLRGIGEALLAAEADPDIRALVLTATGERAFCAGMDLREFADNAGTQPDSDEQRAALEAYARLSAGRTAMPIIGAANATAVGGGLELLLACDIIVASAAASFGFPEVKRGLFAAGGGTAVGTRIPLGIALEMLLTGDLVDADRAHRIGLVNVVAEPDRVLDTAVALATTVAANAPLGLAASKELARLAVTDDAEATRRLKQWQREVFRSADAAEGAQAFLERRTPRWQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAJ2</accession>
    <name>A0A231HAJ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lycopene beta cyclase</fullName>
            <ecNumber evidence="1">5.5.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crtL_1</name>
        <name evidence="1" type="ORF">B7C42_02172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.19" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45880">
        <property type="protein sequence ID" value="OXR45880"/>
        <property type="gene ID" value="B7C42_02172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="366" mass="39258" checksum="8CB96F5649525BAF" modified="2017-10-25" version="1">MSADLIVCGLGPAGRALAHRAAVHGLAVTAIDPHPWRRWPATYATWADELPDWLPPRVVAATVERPLARGTREVEIDRAYQVFGTAALQDALDLSGVRVIADRVLDIERGERVRLASGRILTARRVVDARGLARDARRAEQTAYGIVLHRDREPAVFMDWSRDNGAGADAPASFLYTIPLGGDRVLFEETCLAGRPAIGLDELRRRLEHRLRCRGIEFGADAPVERVRFPVEGGRARDGVFGAAGGLLHPATGYSVGAALAAADAVATGRSLWPVSARLVFALRRAGLRALLALPPHELPAFFDAFFALPPDLQRAYLSGRTDPRGTAAAMTALFRALPWPLRRVLAAAAAGVPVAAATGVRAGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB46</accession>
    <name>A0A231HB46_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45947">
        <property type="protein sequence ID" value="OXR45947"/>
        <property type="gene ID" value="B7C42_02240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29900" checksum="EE85EC678746AC8F" modified="2017-10-25" version="1">MSARDYGDIYSGHARTRKRAVPQVVAERDLVAEDAASGFCGAVVGFERTYDGEFVKLEDRGGRVRLFALREAAFLIDGQPVTLVRPKATAPAAPTRSASGSTRVEGLRARVARASRIWVEGVHDAALVERVWGHDLRVEGVVVEHLEGLDHLAARLTDFGPESGRRVGVLVDHLVTGSKETNLTTGLGPHVLVTGHPYIDIWQAVRPQAVGIEAWPQVPRGEDWKTGVCRRLGWGTPSEGWRRVYNAVDSFRDLEAPLLGAVEQLIDFVTEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBK8</accession>
    <name>A0A231HBK8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating</fullName>
            <ecNumber evidence="4">1.1.1.343</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.343" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781518.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46225">
        <property type="protein sequence ID" value="OXR46225"/>
        <property type="gene ID" value="B7C42_01191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="342" mass="36596" checksum="D3631763F507320D" modified="2017-10-25" version="1">MQLGMIGLGRMGANIVRRIVKDGHTAVGYSRHEDQIKEFTDELGDSFQGATDYPAFVALLEKPRVVWVMIPAGATGAVIDQVADLLEPGDIIIDGGNSRYHEDIKRAAALAPKGIHYLDIGTSGGVWGLDRGYCLMIGGEAEQVAHLEPLFQSIAPGVDAAERTPGRTGEPSPAEQGYLHCGPAGAGHFVKMVHNGIEYGAMAAYAEGLNILHKANIGKELDDAHSAEVSPLENPEYYQFDINVPEVTEVWRRGSVVASWLLDLTAAALHADPDLTSFGGRVSDSGEGRWTIHAAIDEGVPAPVLSTALYERFSSRGEALYADKVLSAMRKAFGGHNELPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC00</accession>
    <name>A0A231HC00_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative endopeptidase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46365">
        <property type="protein sequence ID" value="OXR46365"/>
        <property type="gene ID" value="B7C42_01331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="111"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="23205" checksum="05FD50DBEAC78769" modified="2017-10-25" version="1">MGKHSLQRESRLPNSVKGALVCGAVAATTGAIPAIPAMAATINVPGVGNFDVPLGSDFDQQVSQANQVLADHADQIKGVQQALSSQAIAPGVPNAAQNPMGGMFGQPQQQHGVGDVALDAARSKIGADYVWGASGPSNFDCSGLVQWAYKQAGIQLPRTSFEQSHVGKPVAFQDLKPGDLVIQNGGGHVSMYAGDGKILQAPQSGETVSYAHLDPDSIVTARRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC22</accession>
    <name>A0A231HC22_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46430">
        <property type="protein sequence ID" value="OXR46430"/>
        <property type="gene ID" value="B7C42_01396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4185" evidence="2">
        <location>
            <begin position="251"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="570" mass="60652" checksum="5D34B8E1AA077A0F" modified="2017-10-25" version="1">MFGNNATGRAAADGSVATRGSASIGKRCASAIFTPAVTGLLVFGTLAPVPASAELAPWAPPPKNACGETGFDPLARQPDPNAPAPPILPPRIDIPVPVPEIVPVPVPGPRPDNTRIVPQPLPADPCRNPCPDIRDTPKPPPAEDPSAPGESAPDSGSASGSGSAPGSNSGSGTGSGTGSGSNSGPFNLPNININPEPEPIPIPIPGGEPPAPETPPTPVRPSTDPGAVAAAPAPRTVENVKLVNQVTGHGSVNRTDMRWQVDGTDLGIMWETEPGKVAVVFGDTFGKGWEYGQVGGPDWRSNVLGFSSERDLSKGLIIDDMVQDSRCHAAELLNSRKIKNFETTVIPTSGFALGERQYMSYMSVNRWSRIPGMWWTNNGGLAYSDDGGSTWVKDQYAKWDNMFGIDRFQVATMVPHGDYVYMFGTPNGRIGMIGLARVPKKDVLNKSAYQYWVDGTWAPAQENRATPLLPGIAGELSVRFDEASRQWQMVYLDPARHAIVLRTAAEPQGAWTDGTVLADTNDYPKAYGGFIHPWSTGKDLYFTMSAWDSYNVYLMHATLNDPTAPEPADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCJ1</accession>
    <name>A0A231HCJ1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bfrB_2</name>
        <name evidence="3" type="ORF">B7C42_01498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775100.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46528">
        <property type="protein sequence ID" value="OXR46528"/>
        <property type="gene ID" value="B7C42_01498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="20014" checksum="CB8A39FB74440D42" modified="2017-10-25" version="1">MSGTGPFPDLLRAQIRREFTASQQYLAAAVHFDAQRLPQLARICYLGAEDKRAHALRMVQYLLDRDAAVPVTGTDEVRSEFESPTATVEFLLTRERELTDHITTLTRTARDAGDYLGEQFVRWFLEDQLAEVARLTTLAAVCERAAGNLFDIEEFVAREIPATRTTDASAPKPAGTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCN8</accession>
    <name>A0A231HCN8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46660">
        <property type="protein sequence ID" value="OXR46660"/>
        <property type="gene ID" value="B7C42_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="118" mass="13246" checksum="C36F4A87952937FB" modified="2017-10-25" version="1">MPATATRRLTTTQRGLGHAHRQQVAALLRLHEDGTACWWCGRPMFRDPQRNPDGRTLQGDHSKARSMGGTIADRLLHASCNESRGDGSRDAQRPAVTGQPVENRRSDEDRARWCLMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD45</accession>
    <name>A0A231HD45_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46695">
        <property type="protein sequence ID" value="OXR46695"/>
        <property type="gene ID" value="B7C42_01670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="110" mass="12316" checksum="68ABE7CA2A336787" modified="2017-10-25" version="1">MSGEAFGIVGIVVVCLSIIGIIVAEDIRARRDDGPQPAMRSLRPIASPSHHRAREYPPEWRCAPLRHPMSINRARFEMQDHRACSLDACPRKNQAHAVLVFAGKIIPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDL6</accession>
    <name>A0A231HDL6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47011">
        <property type="protein sequence ID" value="OXR47011"/>
        <property type="gene ID" value="B7C42_00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="76"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="20882" checksum="FB0AF2E3D1276F5B" modified="2017-10-25" version="1">MAILTRLGLPGDEKSWAALGFAVEDGMMRIGRISCTLGVATGWGFEGIEADAATLGVPELLHDVETASAHPNGVTFVDHVVYWVPDLDESVAALNAVLGIGPRRRFRPRGPEGPEMAFYRVGEAFLEVVAAPTKRPALVGVAFGTPDLDATVAAVRAAGGPVGDPKPAVQGGRIAGVWHGHIDWGVAFLEPKPRGDAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDU8</accession>
    <name>A0A231HDU8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47110">
        <property type="protein sequence ID" value="OXR47110"/>
        <property type="gene ID" value="B7C42_00232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="579" mass="64160" checksum="9D59A7013D51FDD6" modified="2017-10-25" version="1">MDKFEDAYHQLWSDLGGLPDAEADTCAGFWFQSDTSAGYYLPNGLTLSLAGDSEVEHHVTHLHEVYHKSLNDSTAWGTAMHLAYEYEPWSQELFGDLRHAAFTTHEVFATFKSINLAEMHYPAASSVLTVGSRYERYYRRARAFVQSVDSAIRQDLLVTAAARVSMQTPILEVARASFPKGFELSAVTNIDRPDGRFIWLLANMAPAVSAISQQADDAVAARFGEDVIHGHAMDRGVEDPEVDDVWDAWEQVVYDEFARQLTQQGATVLPMHDHSETAAHIVGSFPDPGPASLVVAPPDAPPSTDYDESVAILSKTRFPFRKELWPSSFGYMKGAIDPDDFMSVLTQVASVNGVPELVFHARLAGRLTDGYTWDDRTRQQLDALGDEIVVSVKCRTNIGDTDELEIFHVAFKDATDVLEIVEAWGGQGPRAFCISASCFVDSDFAARWVDPLRAKLPIILLLDVPTRVLAGEAEALLPGNQPAYGVYWGLTGTPYKALVWHVDGQPHVGIYIGDSLATQLMYGQFEDIMGENFSMDDADWSEWETTIAAVIRSITYCESFVDLRALESLRKTGKQIDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE49</accession>
    <name>A0A231HE49_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ndkA</name>
        <name evidence="1" type="synonym">ndk</name>
        <name evidence="5" type="ORF">B7C42_00286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777040.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47164">
        <property type="protein sequence ID" value="OXR47164"/>
        <property type="gene ID" value="B7C42_00286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14354" checksum="E6D4CC0F24EC8327" modified="2017-10-25" version="1">MTEQTLVLIKPDGVARGLVGEIITRIERKGLKIAALKLEQVSEERAAAHYAEHADKPFYGSLIEFITSGPVVAAILEGPRAIAAFRQLAGGTDPVEKAVPGSIRGDYALETQFNLVHGSDSPESAKREIALWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEH3</accession>
    <name>A0A231HEH3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Linear gramicidin synthase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgrD_1</name>
        <name evidence="2" type="ORF">B7C42_00300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47178">
        <property type="protein sequence ID" value="OXR47178"/>
        <property type="gene ID" value="B7C42_00300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:fatty-acyl-CoA reductase (alcohol-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="PTHR11011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="1">
        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="38975" checksum="802B1AE6BFA42553" modified="2017-10-25" version="1">MTGHDAVLVTGAGGLIGAEVVARLGAADRTVVGLVHSTARIIRNDGSELDGIETVRGDVRRLGFGLSRHDSAELGSRVGMIVHSAATTAFDATAGEYEELNVRGTAHAIELALRWDVPLVYVSTAYVCGMRAGVVAEAELDVGQAFGNGYEDSKFRAERQVRCTPGLRWAVVRPGVVTGATGTGAIRDYKNLYTVVKLIVEGKLRSLPGRYDATIAPAPVDFVADVITAAATDFDSAARQTFHAVGADALSLRDISDVLAEYPSFQVATFVPETAFAVEDLEPLEREYFQRIGALYTSYFARRPLFDTTATHALLGRDCPPSGKPYLRLLLDHCLESGYLGDPLPSVTEVLARFGPDATVRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEN9</accession>
    <name>A0A231HEN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782084.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47349">
        <property type="protein sequence ID" value="OXR47349"/>
        <property type="gene ID" value="B7C42_00472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="23081" checksum="744F0CFE5320B284" modified="2017-10-25" version="1">MKLDNTFTIPVPAAQAWPVLLDLERIAPCVPGATITSREGDDFHGKIKVKLGPVGLSYNGIIKVVSQDEQAGVAVLEGRGREARGNGTATATITCRLVENNGSTDVFVDTDLAITGKPAQFGRGALADVAGTLIGQFATNLADEITASAQPAEPLRAVTEVPDAGAATATAPRQRATASRTPAEPLDLLAAAGSTQVVRYSGFAAALTLVVLVAVIRRRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEV4</accession>
    <name>A0A231HEV4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47265">
        <property type="protein sequence ID" value="OXR47265"/>
        <property type="gene ID" value="B7C42_00387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="15139" checksum="CDD0E13231FB5B2F" modified="2017-10-25" version="1">MLRGMTTVSYYADDLDAAKRWYSELLDTAPYFEVPRYAEFRIGDYRQELGIIDRRYCPDPEHRAGGALLYWHVDDLDASLRRLRELGAAEHQPVTERGPGFVTASVIDPFGNLLGIMSNRHYLDVLDQRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF25</accession>
    <name>A0A231HF25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Erythronolide synthase, modules 1 and 2</fullName>
            <ecNumber evidence="7">2.3.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eryA_1</name>
        <name evidence="7" type="ORF">B7C42_00688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.94" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47563">
        <property type="protein sequence ID" value="OXR47563"/>
        <property type="gene ID" value="B7C42_00688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047879">
        <property type="term" value="F:erythronolide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="917"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2364"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="952"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="2725" mass="286428" checksum="495DEB5B28FCB892" modified="2017-10-25" version="1">MSMVPLPPSRTAIAVVGLSCRLPQAPDPRAFWQLLRSGTDAITDTPPERWRSADESLRRGGFLDTVTDFDAAFFGISAREAIEADPQQRLMLELAWQAFEDALGRRVGRTGVFVGAMADDYRIVQQRRGDAAIAHHTGVGASRGVIANRISYLLGLRGPSLTVDTGQSSSLVAVHLAMESLRRGESTTALAGGVQLNLVEDSAVRMSRFGGLSPDGRCYTFDARANGFVRGEGGGFVVLKTVPQALADGDRIYAVLRGSAVGNDGAGKDLTTPTVDGQRAVLREAYRAAGVDPAAVAYVELHGTGTRVGDPVEAEALGTELGVPRRTPLLVGSAKTNIGHLEGAAGIAGLLKVVLAVHHGELPPSLNFRTPNPAVRWKDWRLEVVTDRRAWPDGERVAGVSAFGMGGTNCHVVVAAPEPAVADRPASGHTPSGPAVAPRPVPWVFSAVSDAGLRALAADLRAGIPDSDAALPEIARTLAARSGLTERAVVFAPNAEELSAGLRQVSQSESRVVPARDVWSDDRELPVPAGPSVTFRELTELWDFPAAAAESVAFVFPGQGGQWAGMGARLWETSAVFRAWVRVADEVIAAEAGWSVREVLLDVDGAPSLDRVDVVQPALFVTMVGIGLVWASWGIAPDAVVGHSQGEVAAAFVAGALTLGDAVRVVAGRSALVARRLSGAGRMAVVWAPADAVRARLVGAVSVAAINGPATTVLTGAPEALAALVSRYDDEGVRVRWVDVDYASHSPQVEPVRAELVAELAAVRPRRTQVPFYSSVTGARLDAAGVDAEYWFRNLREPVNFAGAVDALLADGFRTFVECSPHPSLAGAVEDAAGPQVVVLSSLRRDDGGANRLLESLAQAWVAGVGVDWASVVGPGPRRRAPEYSFRRTTFWPGAATAAEPGRPDPGARWHALPPARRRRELLGLIRAEAAAVGAADISDAAVSFTGSGFDSVMAIELRNRLSLATGLSLPASVLFDHPSPDRLADHLANLLNDSPAQELPTPLAGAGVQDTSTDDADAIAIVSMACRYPGGADTPEKLWDLVVAGRDAIGPFPADRGWDLAGLFDDEPGRVGKSSARAGGFLYDAPQFDAELFGISPREAAAMDPQQRLLLETSWELFERAGLNVHALRGSDTGVFIGAMAPDYGPRMSEAGERAAGYVLTGTTGGVASGRISYVYGFTGPTLTVDTACSSSLVALHLAAAALRRGECSLAVAGGATVMSTPGIFIEFSQQRGLSPDGRCRAFGAGADGTGWAEGVGVLLLERLSDARRHGHRVLAVLRGSAVNSDGASNGLTAPNGPSQERVIRRALADAGLTTADVDVVEGHGTGTALGDPIEAHALLATYGRDRAGGHPLRLGSLKSNIGHSQAAAGVGGVIKMVQALRHGVLPRTLHADRPSPLIDWAAGQVELLTRNEPWPASGRPRRAAVSSFGIGGTNAHVVLEQAPAVADSAPVARSGPVPWIVSAASADGLREHAAALADFARRPDAPHPRSVAAALATRATLAERAVVIGRTPEDLAEALHRIADAPTRVVAAVPTPASHEDEPVPLGTAALTFPELLAAFGFRFEPVEGVAVLFPGQGGQWAGMGAQLWESSPVFRAWVSTLDVVVREAAGWSVRDVLLDRDGAEPLDRVDVVQVALFAMSVGVALVWASWGIGAEAVAGHSQGEVAAAFVAGGLTLADAVHIVVTRSRLIARKLSGSGGMAVVWAAPERIRPRLVDGVVVAAVNGPEVVVLSGDSQPLRTVADGVEAEGVRVRWVDVDYASHSPAVEAVHDELVDRLVSLRPRSSAVAFYSSVRGGLLDTAELDAAYWFRNLREPVDFTGAVAALAADGFRFFVESSPHPGLVGAVEETVGADGVVVGSLRRGEGGLDRLLTAAGDGWVRGLPVDWPRVIGAAPDADAPTYTFRRQRYWLSAEPPRARIADDWRYRVDWRALPPATARPAGRWLLVGAPDEVRDALSRSRLEVTDDRDSGPLRGALSFRSDIGETLELLRGLPESVPLYVITRGAVGVAGEPLADPAQSVLWGLGYSLALARPDRWGGLIDLPATPLDADLVATLEHALSTATENQMAVRPSGLFARRLVRAHARNDRAPWRSRGSALVTGGTGAIGARVARWLLRTGTDHVVLLSRSGPAAPNAAALRAEFGSAVTIVACDITDRAALDRVIGDIADLRTVVHAAGVVDSTPVTEVTAADIAHVIGPKAVAAQYLHELTGELDAFVLFSSGAAVWGSADQGVYGAANAYLDALAAHRRGLGLPATSIAWGAWDGGGMAAEPGAAQRWRRQGVLPMDPDAALDHLERALRAGESGLLVADIDWSRLAPVLSAARPLRLLAELPEAQPAAEPAEATTGRSFAERLAALPEDEADRALLELVRAEIAAVLGYDAPRADDDDRNLLELGFDSLTTVELRNRLNAATGLSIAVTFLFDHATASELAKALGSELALTDEPPVAPADPVSMLFHQAFESGKFAEGMALLREAARLRPMFDSAATVPHPDPVTLADGDGGPQVICFSALVAMTGAQVYTRFADEFRGQRKVSALPAPGFVSGDSLPATIEAVIDLQTEIVRPIAARAEVVLTGTSSGGWLAHAVAARLERDGLRVAGVVLLDTYLPDADLLRRAQHRVIGGVLDRQAGFGLADGVRLSAMGWYIPLFAHWRPEPITAPTLLVRASEPLRDHTGAALEDLDWRSAWTLPHTVVDVPGDHFTILEEHAASTARAVREWLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF41</accession>
    <name>A0A231HF41_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPK2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47591">
        <property type="protein sequence ID" value="OXR47591"/>
        <property type="gene ID" value="B7C42_00716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="16946" checksum="7EDED8C08D444478" modified="2017-10-25" version="1">MGKKSRHGKEYRRLLRPLQAEPVALQDLPHLPAAGEVVIFDRSWYNWAGLERVMGFRTDEQARHFLGPIPTVEREIVDSVVIMLEYRRHHARVPAGGRATGPAGRQRVSRPTAAAALDSDAVLRIRAEGKDERYGGHTSGVPEFVGGSAGSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFM7</accession>
    <name>A0A231HFM7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator ClgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clgR_2</name>
        <name evidence="2" type="ORF">B7C42_00809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47684">
        <property type="protein sequence ID" value="OXR47684"/>
        <property type="gene ID" value="B7C42_00809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="12763" checksum="16DF1C2A0E7065FC" modified="2017-10-25" version="1">MTLLREAIGESLRRARIAQSRTLREVSTSARVSLGYLSEVERGRKEASSELLAAICQALDVPLSQVLVDVSATMADADTPAPAPETAAAAPAASVSARAGIAGDTRIVIPAPKAEKLVLVQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFN5</accession>
    <name>A0A231HFN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47760">
        <property type="protein sequence ID" value="OXR47760"/>
        <property type="gene ID" value="B7C42_00885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7351" checksum="7F1FB18CA343C83A" modified="2017-10-25" version="1">MRYEFSVDGELSGDICAEFPELARSTVAAPGTTTLFGPLEDYTAMRSVLARIDALGLTLIEMRRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFP7</accession>
    <name>A0A231HFP7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator SrpR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srpR_2</name>
        <name evidence="5" type="ORF">B7C42_00928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779679.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47803">
        <property type="protein sequence ID" value="OXR47803"/>
        <property type="gene ID" value="B7C42_00928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="22689" checksum="CB92B9DA4AC59375" modified="2017-10-25" version="1">MTAANQRARQRLSAEARRRQLETAAIEIVGRDGLAAATADAIARAAGVSKGLLWHYFTDFDDLMAHAARRAFASLEADVAADIDLDADVDDLLRAAIRRAARLPATHGAELRTIRQIVLNLGAFGGGAALRDREYSALYARQATLLRRGQEQGQLRADLDPHLLAVTYQGMVDSMLEYLDTNPDIDPLTYADHVADVLLAGITPTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG07</accession>
    <name>A0A231HG07_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47758">
        <property type="protein sequence ID" value="OXR47758"/>
        <property type="gene ID" value="B7C42_00883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="463"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="650" mass="71561" checksum="9B3B7258C46E5132" modified="2017-10-25" version="1">MTTPDRYSYGPYHDGPDPLAPPVDLREALDLIGRDVMDGSSPRTALEELLRRGTGRTPGLDELTRRLWQRRAELTRQHRLDGTLQQVRELLDQALEAERTALFPDPSDDARFAEAELDALPSSTAAAVTELADYQWRSETGRANYEQIRDLLGRELLDSRFQGMKQALENATPEDVERVRQMMADLNQLLAAHARGENTEQQFAEFMAEHGEFFPENPRDTEELIDALAARAAAAQRMMNSLSPQQQAELSELIGQAFGDPRIAEQVSALDAALRALRPGEDWDSGQRFRGQDPLGLGEGAQAMQDLAEMDALVEQLGQSYPGARLEDIDLDALTRQLGADAAVDAARLAELERELRRQGLFERAPDGSLRLTPKALRRLGEVALRDVVGRLRAQRGQRETVTAGAAGEPTGATRPWRFGDTEPWDVSKTVRNAVLRSASTGSRRVSLSVSDVEITETDQRSRAAVALCVDTSWSMVQDGRWLPMKRTALALHQLISTRFRSDALEVVTFGRHATTVDIGELTGLEAVWEQGTNLHHALLLAARHLRRHPDAVPVVLVVTDGEPTAHLEPDGSSYFNWPPDPRTLAVTMAQVDALAKLGASVSVFILGENPRLAAFVDLMARRSGGRVIAPDLDGLGAAVVSDYLSGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG14</accession>
    <name>A0A231HG14_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="9" type="ORF">B7C42_00760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779580.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47635">
        <property type="protein sequence ID" value="OXR47635"/>
        <property type="gene ID" value="B7C42_00760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="112"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="342" mass="36570" checksum="41ADDAEBCEA06042" modified="2017-10-25" version="1">MNIEIEALRAIVADKGISMETVLSAIESALLTAYRHTEGHEPNARIDINQKTGVVRVMATETDADGNVVSEWDDTPEGFGRIAATTARQVVLQRLRDAENEKSFGEFSTHEGDIVGGVVQRDARMNARGTVVVRIGSEANGAEGLIPPAEQVPGETYEHGDRIKCYVYGVSRGARGPQITLSRTHPNLVRRLFALEVPEIADGSVEIVAVAREAGHRSKIAVRSTVPGVNAKGACIGPMGQRVRNVMSELAGEKIDIIDWAEDPAAFVGNALSPSKVVSVTIVDPEARAARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRSDAAPDVAGSPRPHAQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSG7</accession>
    <name>A0A231GSG7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000547">
        <property type="protein sequence ID" value="OXR39556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39556">
        <property type="protein sequence ID" value="OXR39556"/>
        <property type="gene ID" value="B7C42_08376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7402" checksum="557A3123DA8B0E61" modified="2017-10-25" version="1">MIRIANEAGCAVYDMRGIVAGVGADDPEIGLIQFKVGSGGQAVAFPGEWDKPINPILYKAFDLYMKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSR5</accession>
    <name>A0A231GSR5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator ZntR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">zntR_2</name>
        <name evidence="2" type="ORF">B7C42_08311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000127">
        <property type="protein sequence ID" value="OXR39622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39622">
        <property type="protein sequence ID" value="OXR39622"/>
        <property type="gene ID" value="B7C42_08311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="13686" checksum="68355AD7BC2668E5" modified="2017-10-25" version="1">MLIGELANTTGVSTRLLRYYEEQGLLSARRDGNGYRVYTGDAPQRVHRIRELLAAGLSTSAIRELLPCATATGLQHCDHTRKIMREGLSHLDAQIAELTRRRTLLARQDEQLVAAPYRSDGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSZ5</accession>
    <name>A0A231GSZ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000083">
        <property type="protein sequence ID" value="OXR39702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39702">
        <property type="protein sequence ID" value="OXR39702"/>
        <property type="gene ID" value="B7C42_08226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="71" mass="8040" checksum="387F513A1B206583" modified="2017-10-25" version="1">MNSSDVAVLAVLSPGGLLTTAQIRRDAELPWWRVRFALTHLSSRGFIVFCNSWARWQISERGRSALAERQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT66</accession>
    <name>A0A231GT66_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="6">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_08157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000068">
        <property type="protein sequence ID" value="OXR39772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39772">
        <property type="protein sequence ID" value="OXR39772"/>
        <property type="gene ID" value="B7C42_08157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032371">
        <property type="entry name" value="DUF4873"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16170">
        <property type="entry name" value="DUF4873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4873" evidence="5">
        <location>
            <begin position="496"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR39772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="611" mass="68356" checksum="C081F0A6DC7C7388" modified="2017-10-25" version="1">MSGREDQLYEVVVIGAGFGGLCAAAKLREAGIDNFVVLEKADEVGGTWRENTYPGAACDVMSLMYSYSFAPNPAWTRGYARQPEILEYLKNFAADQDLLQSIVFGTEVVSQIFDDDTDTWILRTAGEDTFRTRSVIDATGPLHVPSIPDLPGIERFGGTTFHSSRWNHDFDLDGKRVAVIGTGASAVQFVPEVAERAGQLSVFQRTPNWVLPKFDRRIGIVERMAYTAVPGLRRLVRAGIYFSHEAATAAFLNPKYMPIMRKVAQWHLDRQVPDPQLRAQLQPRYEMGCKRIVMDNRYYPALQRENVDLVTASIQEVTEDAIITADGSRHPVDAIIFGTGFKVTDKTQDMHLIGRNNRTIQQVWAQGVEAYLGVAANGIPNYFMLVGPNTGVGNQSIVFIIEAQVRYIAQLLVALNDRECTRVEPKAHVQAQFNRELQRKSAGTVWTAGGCTSWYLDENGVNRAIWPDTTMTYWRRTRNANLSDYEFTRHTDREEDEDYSGPAVLIDTDGNRYDVRVHVLATYEPVENTIRWYGRVAPSPSLRELHIRNNQPVHLQIGDNEPVDGLLIDTDPWGGSRIHGRGAYPYPPPLDAELAQLFSLTAPGDQGGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTJ5</accession>
    <name>A0A231GTJ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03620</name>
        <name evidence="5" type="ORF">B7C42_07977</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000050">
        <property type="protein sequence ID" value="OXR39943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39943">
        <property type="protein sequence ID" value="OXR39943"/>
        <property type="gene ID" value="B7C42_07977"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44064">
        <property type="protein sequence ID" value="OXR44064"/>
        <property type="gene ID" value="B7C42_03620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="4">
        <location>
            <begin position="122"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="267"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="590" mass="62032" checksum="C744CBFF9FD8C34B" modified="2017-10-25" version="1">MDERDASEPVAKQADNAETGAGPGSASGVGPHRDGTAEPDTAAQAGGPEESGARPGRPRGVSRRWLFGASGAAAIAGLAVGAGTTAALHGDGSSTGSGGRFWPLSPDLAMSPSRVAAPPVTGLHLQFGADAAREAVVSWQSSASVRNPVVRFGTATTGFGATAQAQTRVYRDAASGTEVYAHHAVLTGLTPDTDYIYAAGHDGATPELGTHRTAPAGRAAFRFTSFGDQGTPTLGKLDNGRYVNDNLGSPVAGDVTAGIEHLAPLFNLVNGDLCYANLATDRIRTWNDWWANNSRSARHRPWMPAPGNHENERGNGPIGYEAFQTYFTVPDSGSEDLARGLWYAFTVGAVRVIAVANDDICLQDGGNSYVHGYSGGAQKRWLDKELAAARADRAIDWIVVFMHQTAISSADKANGADLGIRQEWLPLFDRYQVDLVLCGHEHHYERSHPVRGVLGSDTLTPKPVPEAVTPATATAPDIIDTSRGTVHLVIGGGGTSVPSNGLFFPGQQCRVITGVGAVDPATGKKAPIYVMEQAPWSAFKDPDHPYGFCAFDVDPGAPGGHTTMTATYYAVTDTLKPVDSFVLTRPRSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTS3</accession>
    <name>A0A231GTS3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39881">
        <property type="protein sequence ID" value="OXR39881"/>
        <property type="gene ID" value="B7C42_08056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="7455" checksum="1781C4568973DF14" modified="2017-10-25" version="1">MPIAVSSARVHEILNYFGKCPDCGYAARGAIIATRYVDGSMDSRVVATCESPCGWSGPAEGSLMTGTNAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTT4</accession>
    <name>A0A231GTT4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TraG-D_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40033">
        <property type="protein sequence ID" value="OXR40033"/>
        <property type="gene ID" value="B7C42_07878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="3">
        <location>
            <begin position="441"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="616" mass="66435" checksum="FE8FF85433C6F6E8" modified="2017-10-25" version="1">MARQTRRRTTGGFGEETWLLLIALGVTAMALLAWAALSVGSWCAGLPVTAHPVAALLQVMAGRHRWPWQSSVVMAIALAAVGASAVMSRGRWVSLRSSDIDRAARTMVAPRRISAARQQDNASAAERLLKDAPADVRTLPGPPLGRTVVGGVELFVPAEMGVFIAAGQRTGKTMAWAIPAVLSAWGPVLATSNKPDLYRHTAFGREQRGRVWMCDLQAVTGQPVCGFWVNLLDRVRTLAAARKLASFFVSGASGSASERANARVDSYFDGGAQELLSLYLLAAACVSGDLLHVAEWLSSDQDQTPILILRHHNHRRAAQRILDAQGLYARQRDGLYDMARRFLNVLSDEGYATMITPPSRTHISVYETSDSIIIDTAPGPATHNLPEFKPAEFVTSNDALYALSMTGPDSASALTAALVGQILESALRIARARPDGRLAVPLLAVLDEAANCALIDELPSYYTYAAGCGVILLTIVQVLEQAEDLWGANGLTVIRAQSIEIYGGNIATPTYLEQWARLVDDHDVADHSRSTGPGGTNRSTSWRAEPILNVAKLARLPKDRALVRLPGHEPVLIEKQFWWDNPALEPLITQSLARFTRPPRPPARPENTGGAAGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTV5</accession>
    <name>A0A231GTV5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782773.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40054">
        <property type="protein sequence ID" value="OXR40054"/>
        <property type="gene ID" value="B7C42_07858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="102"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="33713" checksum="2DBD43ED97FF117C" modified="2017-10-25" version="1">MLATAGRPPENSDLWGFEMKWDGMRAIGLVDGEQVSLFSRNGREATASFPEVAAALADTSAGRRFIIDGEVVAPDLASGVPSFGRLQHRMHIGRPPAGLIASVPVQLFVFDVLSIGDTDLTGRPYTVRRELLAALELTSTLVRVPPYWTDVAPQQMLDTAAEHGLEGIVSKRLASVYRPGQRSRSWIKTALRRSADVVVAGWIPGSRPRSGLFGSLILGAHTTAGDLVYVGNVGTGFSVAERRVLQARLDEIARQASPFAVAPRFGPVPAYWVEPGLVATVFYREFTTTLRHPSWAGLRADRDSRDVGLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU56</accession>
    <name>A0A231GU56_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coenzyme PQQ synthesis protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pqqE</name>
        <name evidence="6" type="ORF">B7C42_07773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000039">
        <property type="protein sequence ID" value="OXR40149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40149">
        <property type="protein sequence ID" value="OXR40149"/>
        <property type="gene ID" value="B7C42_07773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="12"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="427" mass="46704" checksum="D7C7F6023EE7B285" modified="2017-10-25" version="1">MFNETRPCAPEDVGRVVRLVIDAVNECNLRCLYCHPGQVWRQQQLPLPAVWAAMEAAEAAGVLEVVLTGGEITLHHSLPGILAATHLLRRTASTLITNATQLSSPIIDGLAASNLTRICTSVDGATNDVHGSARGKNLPKVLEGLHALKQTGKPITVITVVHQSNWREVIELSAFLAVNGLASQHHLCAPSYSGQARTHYPRLALREHEFHAVQELVNRHHRELAAAGLYLTFNSMWPATGVRPLATNPARTITLQQLSEQVKDTLCNIRPNGEFRLQAATWGREMVGNAVLGSVHARPTAELLAHAETLLDQGTPRQLPREVEAQHKFQLGATASRDTTEQLIGRTDAPAHDPDLIPIRSIDHHWLLDNPADTTDIAAQISARPDNYRVVRHPSGIVLAFDRSRSFVTLLTPAEWAEIVAPTQVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU66</accession>
    <name>A0A231GU66_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000039">
        <property type="protein sequence ID" value="OXR40159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40159">
        <property type="protein sequence ID" value="OXR40159"/>
        <property type="gene ID" value="B7C42_07783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="26638" checksum="8335603518CDCFD5" modified="2017-10-25" version="1">MVAQTNPQRAETIARTIANPNRQAKALAAIARVVAQTNPKRAEAITDTITDPLWQSSSLIGITEAVAGTDPERATRLTERAETIAHTITNPTSRANALAIIARVVAQTNPKRAETIARTIANPNRQAKALIRIVRAVAATDPEHAARLTEHAETLAHTITDSNQQAEILTAIADVVAGTEERCEAIELTSESSGALARSGLCGCGRSSKQLLARAWSISTLEIPVSALPVVDTSTLHALVLDLTDEKDANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUD3</accession>
    <name>A0A231GUD3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">B7C42_07741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776818.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40226">
        <property type="protein sequence ID" value="OXR40226"/>
        <property type="gene ID" value="B7C42_07741"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="44370" checksum="13ED965C10BA9F7C" modified="2017-10-25" version="1">MSERFLVTGGSRLVGEVSVGGAKNSVLKLMAAALLAEGTTTITNCPDILDVPLMAEVLRGLGCDVTVDGSVVAITTPAEPKYHADFPAVTQFRASVCVLGPLMARCKRAVVALPGGDAIGSRPLDMHQAGLRLLGATSEIEHGCLVARADELQGARIRLDFPSVGATENILMAAVLAEGETVIDNAAREPEIVDLCTMLTRMGARIDGAGTSVLTISGVRKLAPTTHQVIGDRIVAATWGIAAAMTRGDVRVTGLNPKHLSLVLDKLRSAGARITFEPNGFRVEQPERPRAVNFSTLPFPGFPTDLQPMAIGLATIADGTSMITENIFEARFRFVEEMIRLGADARTDGHHAVVRGIPRLSSAPVWSSDIRAGAGLVLAGLVADGVTEVHDVFHIDRGYPHFVENLRSLGAEVERVGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUG4</accession>
    <name>A0A231GUG4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase NlhH</fullName>
            <ecNumber evidence="2">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nlhH_6</name>
        <name evidence="2" type="ORF">B7C42_07785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40121">
        <property type="protein sequence ID" value="OXR40121"/>
        <property type="gene ID" value="B7C42_07785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="89"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="34491" checksum="94F01B7738AFB903" modified="2017-10-25" version="1">MTASSGYKPYQFAWDPDVEVILERVRANKSGPMHAAGVDAARRSLESIVRPPGPDMRTVRDATFDGPHGAVPVRVYHPLTAPESDAPALVWFHGGGMIMGTLQSFDRLARDIADATGAVLFNVDYRLAPEYRYPVANDEAYAALCWAVDTASNWGVDATRIGVGGDSAGGGLAAATTLRSRDDNGPAIAQQVLFYPGVERRTDRPSMREFGSSPFLTAEDIDWMKSLYLGPDPSTDDAYGVPALANSLADLPPAIIAVGYADPIRDGVEAYGDRLREAGVPTVQLRYPGVGHGFAMQAPSVARGRAAIAEVGALVAARFRQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUN4</accession>
    <name>A0A231GUN4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40339">
        <property type="protein sequence ID" value="OXR40339"/>
        <property type="gene ID" value="B7C42_07600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="56" mass="6407" checksum="999437C8B48F9BA1" modified="2017-10-25" version="1">MYGVMNHERVPVMTVDFAHAIMQVHIDCALSICPVKQQAKQRLIEANRLVPDSNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUU7</accession>
    <name>A0A231GUU7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione-binding protein GsiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gsiB_2</name>
        <name evidence="3" type="ORF">B7C42_07565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40399">
        <property type="protein sequence ID" value="OXR40399"/>
        <property type="gene ID" value="B7C42_07565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012330570" evidence="1">
        <location>
            <begin position="36"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="94"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="520" mass="54866" checksum="4964E1FA20F1CE47" modified="2017-10-25" version="1">MSLSVQRSNRSAPTIVSRRALLRLGLGAGALFALAACSDAGAGSVGGGGPGTVSWAWQLPTTWDPVTSSAGSDVTMLALAYDALTALDGDGNAVGWLAEKWAYNHDGTQVTFTLRPGLKFSDGSPLDAAAVAKSIERGRSAPGSLIAPQLVDLKKVAAQGDRDVVIDLAGTNYQYPLLLAGKTGMVVNPAVFEKDAHALATRPAGSGPFTLTSYVANDHAELRKNEFFHLADQIAITRFLLYPAADPATVVASVASGQYDVARVPASGIKAAQASGLEVQVLDSMYVAVLDVNTSKPPFDNPAVVEAMKYGIDRESIKKIANFGIGDVGYQPFPKGYVGYNAQLAQAFRYDPAKARKILADAGLSGKVRSTLSAAAPVPAAVEQIQAQLADIGIELEIDLVPPSQWTQIVYLNRGKPLGYDGFAGRESPLQAFQVLFSPTGLMNPSRSGDPELAAQLAKVAAIPTDAPEYPAALQEATRIAVTRFPNTFLYEVPSILVRRPSLAPLKRHPSLLRWEGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUV1</accession>
    <name>A0A231GUV1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40261">
        <property type="protein sequence ID" value="OXR40261"/>
        <property type="gene ID" value="B7C42_07686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="7224" checksum="1FEB741F90A422C0" modified="2017-10-25" version="1">MPRVTADLSADLHHELRAWLADSARELGVTRVTWQSVAEVLVQQLTTDPELTQAVRDRLAAASAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUY7</accession>
    <name>A0A231GUY7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaE_4</name>
        <name evidence="11" type="ORF">B7C42_07531</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40365">
        <property type="protein sequence ID" value="OXR40365"/>
        <property type="gene ID" value="B7C42_07531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="10">
        <location>
            <begin position="31"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR40365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="22191" checksum="7C4760A2BCDF48F1" modified="2017-10-25" version="1">MTVSDEPASVGKPVAPDDVSRSPRLPGDADMWVMVLGDLFFFGCYFVVYMVFRTRSAGDFAAAQQHLNLSIGVVNTIVLLTSSMFVALAVISARQGVVASARRLLAAAGGCGVVFAMLKACEWYLEISRGHTVGTEFFSFYYALTGIHLAHLLLGMLILGVVGRELRNSRRPRVGLVEQGAVFWHMIDLLWIVIFAIVYLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV48</accession>
    <name>A0A231GV48_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-perosamine synthase</fullName>
            <ecNumber evidence="2">2.6.1.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">per</name>
        <name evidence="2" type="ORF">B7C42_07510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.102" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778544.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40452">
        <property type="protein sequence ID" value="OXR40452"/>
        <property type="gene ID" value="B7C42_07510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102933">
        <property type="term" value="F:GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="45265" checksum="F340CA4A087CA044" modified="2017-10-25" version="1">MTRVIYARSVHDEAEINACLEVLRGGPFALKIGKNVAEMEQRVADLYGKRLGLMCNSGSSALYLALELLDLPKGSEVITSPLTFSTDVSPIVRGGWIPVFVDVEPDTYNVDASKIEELITEKTKAILLPNLAGNAPDWDAIREIADRHGLKVIEDSCDCIGTTLRGEKTGARSDITVTSFAMSHIITCAGNGGMVCVDDEKLRDKGLMLRRWGRRSEPHLFGSEAAKTGRVFREDLDGVAYDNDFIFDVLPWNFEPSELGAAFGLVQLSKLDINYKRRAEIFDAFTGAFGSYPSLFRLPKQLPGFHTAWLCYPVTIRQDAGFTRSDLQEHLESAGIDTRTVWSGNVTRHPMMRNVEYRIPSSGLPNADEVFERGMSLGMSHGTTDEELTHVVNSIHDFARRYAAEAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV65</accession>
    <name>A0A231GV65_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40371">
        <property type="protein sequence ID" value="OXR40371"/>
        <property type="gene ID" value="B7C42_07537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="19162" checksum="1519F4731548D325" modified="2017-10-25" version="1">MARVCAEANLSTRQFYEEFASRDELLFALYDQGQEISGRFLAAALANAPAQEYTRDLIHRNIEAYVDSFAEDPRWATLLFVTVIGVSPQLEAHRRQTRENWIGVQCAIAEELVRQGRIPHRDFRPIFVAFVGAIDGLVYDWCHTDPRPAKETITDTLTHMLFHALNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVB7</accession>
    <name>A0A231GVB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative monoacyl phosphatidylinositol tetramannoside-binding protein LpqW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40569">
        <property type="protein sequence ID" value="OXR40569"/>
        <property type="gene ID" value="B7C42_07378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850510" evidence="2">
        <location>
            <begin position="24"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="115"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="593" mass="62068" checksum="9AFAAFB425B22312" modified="2017-10-25" version="1">MRAGRRVVLVLMVALGVLTACTANPPPPIESTDSPKTTPATPTKSTVVVAVDDIGIGFNPHLRSNQSPATNAVASLVFPSPFRPVPSPTVPGGTDRVPDAALMVSADVTPSDPSQPDLFTLTYKIQNQASWSDGAPIAAEDFRYLWQQMISQPGVVDPAGYRLINDVKSSEGGKTVTVTMSQPYPAWRQLFSDLLPSHLLKDAPGGFQRALAVERGLIDQNPISGGQFRVKQADAGREEILLERNDRYWGTPAVPDQILLRRGGTPAQLAESLRAGDAQMALVHGGVATQAQLAAIPQVRTAIMPQAREMQMVLNGRTGDLSDPRVRHAVLGLLDPALLASVGAETGAWVDPVRAQILAPSDPGYAPTAPPRPSPDQAFGLLAEAGFGRAPESPASGNPTTSPAPQPRPVAKNGRTLTIRIGAVDKDPTTLAVANTAADQLRSAGIDASVRSLPADELYGKDLADGTVDAVVGWERAGEDPATILSSRYGCPPVAAPGQEDTSQIDAIRKAPSNVSGICDPSLQPQIDAALRGVDVPKAIGDAEPKLWDLATVLPIVQDTGVAAASSRMDGVSLSGSIQVGIFGGASTWRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVG6</accession>
    <name>A0A231GVG6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 107B1</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064901995.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40627">
        <property type="protein sequence ID" value="OXR40627"/>
        <property type="gene ID" value="B7C42_07312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="44122" checksum="54D467B3238F6748" modified="2017-10-25" version="1">MTRAEPDDLLRQMLLTEYGESGPYEGYRLLRETAPVLVSASGVVVLSRYADCQAALRNRRLGKADESLGFRLTDVPEDLQRTTLHRFRRTMLFRNPPDHERLRRLVADAFTHRHVEQLRPRIAERIDHLLDAAAERERIDIISEIALPLPVAVIGDLLGVPESDRAAAAPLVRCLLAPLEPASDTAAIRRAADAETQLVEYFSTLLAEKRTDPQDDLLSRLAIARGADALDEDEMVGSAILLFAAGFETTTNLIGNGLAALLAHPDQLAALRDEPALASNAVEELLRYDAPVQTNGRTALADTAIGDVSVPDGTVVLMLLGSANRDPDRYDDPDILDLRRRNPAPLSFGSGIHFCLGAALARTEAMELFPRLLARFPGLAADGEPVWRPGLSFRGLASLPVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVP2</accession>
    <name>A0A231GVP2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40693">
        <property type="protein sequence ID" value="OXR40693"/>
        <property type="gene ID" value="B7C42_07251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="23961" checksum="13BFB6957EEA7B80" modified="2017-10-25" version="1">MFISDRSVSHNRHTCPTVTRRRRRASEFPPRPARSCARPSTAPRRSGRATAGNAASARRGCGNDHRLAGRRVPRADTLGELPTGVDHRSHPFLVARECRAVITTSRGRFGGRHTGADQRQIQTLPKEALLGEAPAQATRDWGTELAGAVADYRAPSNNSSSPTYIRPAAQHRTVGVIPHPRTAIQGRPAAVTEPETSATESNPHHSATTCPGTRRKIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVU6</accession>
    <name>A0A231GVU6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40734">
        <property type="protein sequence ID" value="OXR40734"/>
        <property type="gene ID" value="B7C42_07158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="21216" checksum="B1CA14DBDCA687AE" modified="2017-10-25" version="1">MRGPIDNSRDEPPLLEEPADDLVEDGQPDYLKKSADSARMGKAAEYLVAAICILATRGQLNVSTSIVDDEGVDLVFHLRGQAATLAVQVKARMSDGSAAARGRFQALVRQATFQPRRNLDLLFILVNIKHGTISAAWLVPSPDFEQLTGTPTSRGMLRFAASASPNSQDKWSGYRLAAADLPWRIVERVQELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWC4</accession>
    <name>A0A231GWC4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40927">
        <property type="protein sequence ID" value="OXR40927"/>
        <property type="gene ID" value="B7C42_07062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="21480" checksum="BB63DD3928789C9F" modified="2017-10-25" version="1">MISRCARRLFCELDRMDEPMQILARLCMTADGYVTTPDGWPPQVIDPVHGPGSHGIAEFLRTCEAALMGRTTFEPALSADRWPWPELEVFVLGSHRPEGTPDDVTVDDDPVRLLEKVRAANRGGDVHLIGGPATIETYRALGVVDKLELVILPFFVGSGIRLTDSLDPRTDLEFESSRPLDGGGVEIVYRVLPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWK8</accession>
    <name>A0A231GWK8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40986">
        <property type="protein sequence ID" value="OXR40986"/>
        <property type="gene ID" value="B7C42_06952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12606" checksum="9A672FFF3B2B99AE" modified="2017-10-25" version="1">MIECTRARHPASTAEPRMSDEVGDTRSPASRADGRIDGVSTDTLVRPDTTTDETTDSDTPKFFHYVKKDKIAESAVMGTHVVALCGEVFPVTRSAKPGSPVCPDCKRIYEMMKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWZ1</accession>
    <name>A0A231GWZ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase PuuC</fullName>
            <ecNumber evidence="5">1.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">puuC</name>
        <name evidence="5" type="ORF">B7C42_06855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.5" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41085">
        <property type="protein sequence ID" value="OXR41085"/>
        <property type="gene ID" value="B7C42_06855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="28"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="496" mass="53068" checksum="58F6BD02216B4CDD" modified="2017-10-25" version="1">MTTSGTEQLRTLAATVPTSFGMWESGVWADAADSETLPLRDPWTGEQFTTVPSAAPADVDRIVKNARAVFDSGVWSRMAPTERGRVLIAWADLIERDADRLAVLISREMGKPVHQARDFEVTSAVRNLRWYGELADKLMDDSPRGLQDAVALVTREPLGVVAAITPWNFPISLAMLKLAPALTAGNSVVLKPALQTSASSLRLAELSSLAGLPDGVLQVVTGRGATVGTALSRHHSVACVTFTGSTEVGLRLLGDSAVSNGKPVSLELGGKSPNIIFADAPDLEQAVRTATWAFTFNTGQMCTAGSRLFVERSVYDEVVAGVCDRVSTLTIGDPLDPGTVLGPLSSRNQCDTVLEFVKSGVREGATLLTGSEQALDEERSLVAPTVFVDTDASMQITRAEIFGPVVCIQPFRDEDEALRLANDTDFGLGASVWTRDVSRIHRMARGLDAGNVWVNSYEEGVPSTPFAGRNLSGNGADKGTYGLEKYTQLKTTWIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX47</accession>
    <name>A0A231GX47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ESX-3 secretion system protein EccB3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">eccB3_3</name>
        <name evidence="12" type="ORF">B7C42_06790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41194">
        <property type="protein sequence ID" value="OXR41194"/>
        <property type="gene ID" value="B7C42_06790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR41194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="521" mass="54221" checksum="8D41BCE3C787FC8F" modified="2017-10-25" version="1">MARFRVVTKHQISGWRFLLRRIEHALVRREVSMIDDPQRGRSTALSIGIALACVVVAGAAVMAFFKPAKQVGNADIVADKNSGALYVKVAGRLHPALNLTSARLISGKAADPVPVSQQELDKYPRGPWVGIPGAPDSIVGSTDSDSSWTVCDTTRTGADAPIDRTTGLPTTAGSAVVTTAIGGPLTVDDETTHALSGDQARLLRNGSITWLVYDDRDKGVVRAAIDLRDSAVTLALGIDATMPIPQASRGLIEAIPEMPPLRVPDVPGAGGVTTLSSGLSVPVGSVLSVSSPDRPSSYYLASQSGLVQISAVLAAVVRNADSHGTATTMAVGPDVVAANLRPGTWPGTEDYPARAVQIVDANRYGVTCYHWSRGGRDPNASTQVLYGRRLPLTAEQQTRIVGLVTAPASHGATADTAYLPGGTGRFVQVTGADPASPLRESLYWISDSGVRYGIDVAPGAIGDQTLAALGLRAPLPAPWSVVSLFAVGPVLSQRDARVQHDGIPSDKSAVGLPQQSEGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX81</accession>
    <name>A0A231GX81_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41209">
        <property type="protein sequence ID" value="OXR41209"/>
        <property type="gene ID" value="B7C42_06607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13605" checksum="D7DEBEAE1FC37927" modified="2017-10-25" version="1">MDESTTIIAKTIGSPAGIDDNPWESGHPADGERVAIFAFAVTGVDDRSADIRTYHVTPPDQAREGTVVPEHRSPQGVVTTWLGCGTGTVVEPATHLDIQQAMMDLDSSAKTMFECRVRPDNPDLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXA4</accession>
    <name>A0A231GXA4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41250">
        <property type="protein sequence ID" value="OXR41250"/>
        <property type="gene ID" value="B7C42_06648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="14"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="361" mass="38215" checksum="85CFB5F630536CAE" modified="2017-10-25" version="1">MDLTTKHTISTAGVDTHAHYYGLDLTERLPGLRDPRWPTLHRDARDGGSIMLGDRLFRKVRSVLWDIDERIGELDAANIGVQLISPVPVMLAYWADQTVGVACARATNDSIAAAVARSGGRLAGLGTVPLPHTAAAVEELERVIIELGLSGVEIGTRVAGQDLDSPGLVPFFEAAESLGAAVFVHPTDGGGGVIHRGGQPYDFGLGMITDTAVAATSLIFGGVLERFPKLRVALAHGCGTFPWAYPRLRLGAKIWLGANEDRVQELVRSLWVDSLVFDPAHLSLLVERFGSDHVMLGTDYPFIPGQLEGAAGFLRSAQTMAAIDAPTAHAIHAANGSAFLRAPTGIATCTTVFDAGGSPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXP6</accession>
    <name>A0A231GXP6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigJ_9</name>
        <name evidence="8" type="ORF">B7C42_06485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41342">
        <property type="protein sequence ID" value="OXR41342"/>
        <property type="gene ID" value="B7C42_06485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="31129" checksum="025283709FA14126" modified="2017-10-25" version="1">MSEREQALQRLHDQRPRLRALAHHILGSAVDAEDAVQETWLRVHRSPPRAVGNIDAWLTTAVAHTCLDLLRARRSRREYPSGTRLPDPLLVADHRSGPEEQALLSDSVSLAIQAVLTQLDPAERVAFVLHDIFAVPFDRIAALLDRTPAAARQSASRARRRLRAAPTPEGDLGDQRVVVDAFFAAARRGDFEALVAQLAPDIVLRADAGAGGGWEIHGPRDTATRALLFARPSSDVRPVLVNGAAGAVIMFGGQPGVLIAFTVTNERIAEIYVYADRERVAGFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXZ2</accession>
    <name>A0A231GXZ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780359.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41445">
        <property type="protein sequence ID" value="OXR41445"/>
        <property type="gene ID" value="B7C42_06588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="14171" checksum="A5896295BFC65DC5" modified="2017-10-25" version="1">MRRCCRPGCKNPAVATLTYVYSDSTAVVGPLATVAEPHSWDLCETHGSRITAPKGWELVRHEGGFSSSTPDDDDLTALAEAVREAGMRRRPPEPEQRGYSEYAPPPARPQRPGRTGRRGHLRVLPDPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY83</accession>
    <name>A0A231GY83_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783597.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41584">
        <property type="protein sequence ID" value="OXR41584"/>
        <property type="gene ID" value="B7C42_06225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="8567" checksum="B94AA4488CDDCF46" modified="2017-10-25" version="1">MSEPENSAACGAALDTQLRLFCHLMLGSADAADRMMRQIYRHAPDHHDDQRNRHSERARLFGIAADLCGVRNCSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY97</accession>
    <name>A0A231GY97_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41542">
        <property type="protein sequence ID" value="OXR41542"/>
        <property type="gene ID" value="B7C42_06435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="7711" checksum="134D14BF0108F28A" modified="2017-10-25" version="1">MHNDVHMRIWLGGTAFDYRTAAAAVDNIVRDWRRKRWCTIEFILDTIDGRLPENRLPNERLFLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYE9</accession>
    <name>A0A231GYE9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41626">
        <property type="protein sequence ID" value="OXR41626"/>
        <property type="gene ID" value="B7C42_06267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="8909" checksum="4BD3600F0BC6EC9C" modified="2017-10-25" version="1">MMIAVALLAMALAAAAGGHGGLLLVAAGACAAVAIFGLLVFESTVRRDHLERHDNPHLLSDSYVDDQLWKAVISARDRSTPKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYG1</accession>
    <name>A0A231GYG1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative deferrochelatase/peroxidase EfeN</fullName>
            <ecNumber evidence="5">1.11.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">efeN</name>
        <name evidence="5" type="ORF">B7C42_06295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41654">
        <property type="protein sequence ID" value="OXR41654"/>
        <property type="gene ID" value="B7C42_06295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="42469" checksum="95357D3B803DD1FB" modified="2017-10-25" version="1">MAERLSRRRLLGGSAAAAGAAGVAGLTLGAERWTRHTETADPGTAREPFYGPHQGGVATAPQQHAVFVAFDLRPGTGRADLVGLLRIWSGDAARLAAGEPALADTEPELARRPARLTVTVGFGPRLFTVAGLESARPQWLAQLPAFTIDRLDSAFCEGDLLLQVCADEATTVAHAVRTLSRSVTSLVTLRWTQRGFRNAAAGQTMRNLMGQVDGTVNIAPGADLDRLVWDDGATVPWLRGGTSMVLRRIAMNLDTWDELDPEGRELTVGRRIATGAPLTGTRESDDPDFAAVDAHGIPVIPPSAHIARAHHTRDGERFLRRGYNYDDAPAPGTTSNSGLLFAAYQRDIAAQYLPVQRRLAEFDALNTWTTPVGSAVFVIPPGITDAQGYLGQTLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYR5</accession>
    <name>A0A231GYR5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41746">
        <property type="protein sequence ID" value="OXR41746"/>
        <property type="gene ID" value="B7C42_06088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="19737" checksum="99609FF2F7DF8526" modified="2017-10-25" version="1">MGDTLQVGRELGLGQALQGGAYTLTLQNDGNLVLSEPDGTVVWATMTHERGVERAVLQEDGNFVLYSGSGPVWATDTNGQAADHLIVQPDRNLVLYGRDGASLWASGTNTDNPIVVEEPVAAPAAEQVPPPPPAPEPRTYTVESGDTLWAIAERFYGDGNRYLEIAGASGIENPDVINEGQLLTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYS0</accession>
    <name>A0A231GYS0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41671">
        <property type="protein sequence ID" value="OXR41671"/>
        <property type="gene ID" value="B7C42_06312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="30832" checksum="45A2E4526576CDED" modified="2017-10-25" version="1">MSDLEAHLAPLLGMPVVAEHTVGHGHAWTLYRVRLADGRDAFVKSAAGAPGSTADHALTAEAAGLRWLREADAADLIPQVLGADDRTLVLPWLTSVAPSREAAERFGGALADLHAHTVDRYGAPWAGCIATVPQDNATVAGEWGPWYARYRLQPLVPAAASVLGRNGIRLIERVIDEIGALAGPPEPPCRIHGDLWSGNVLWTERGVMLIDPAAHGGHRETDLAMLRLFGAPHLGHILGAYRERLPLAPGAEQRVALHQLYPLLVHVVLFGGGYREQAIAAAEEALSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZJ9</accession>
    <name>A0A231GZJ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">oppD</name>
        <name evidence="5" type="ORF">B7C42_05966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41982">
        <property type="protein sequence ID" value="OXR41982"/>
        <property type="gene ID" value="B7C42_05966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="28751" checksum="6E6C53918B8FFFE4" modified="2017-10-25" version="1">MTLLEVADLTVRIDGRTVLDGVGFDLAAGDRLGVIGASGSGKSLTALAILGLLPDHADVRGSIRFDGVELLGRSDRELSAIRGHRIAMVFQEPLSALNPLMRVGKQIGEPLRIHRGLSRKQALAEALSLADRVGLPDPEHLIRAYPHQLSGGQRQRVGIAMALASRPALLLADEPTTALDVTVQAEILGLLDDLVVDQGTALLFVTHDLAVLARIVRRVLVLGDGRVLEAGDLPQLLREPAHPYTRTLLELARASAFRRGTPDAVGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H059</accession>
    <name>A0A231H059_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aliphatic sulfonates-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ssuA_6</name>
        <name evidence="3" type="ORF">B7C42_05845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779731.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42246">
        <property type="protein sequence ID" value="OXR42246"/>
        <property type="gene ID" value="B7C42_05845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011224684" evidence="1">
        <location>
            <begin position="37"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="36257" checksum="965F75622B9A1D19" modified="2017-10-25" version="1">MFRTRRPHGWRLALALAPVVALVAACGSGSATESGAGSQLVLKVADPGNAGPLAVAKRDGTFDKALAPLGAKVEWVNTTPGFSSMLKLFNTKQLDISGAAFSPVVGALSKDVAVRIVAVQDPAGKDQSGIIATKESGIHSVAELVGKRVAVNPAGKGEYILLKALAQAGVPADKVTRVPLQQKDAASAFATGKVDAWASFLVPYQEAKANGGVEIATEQSIGSKDNTVVVFRTEILDKRPEVAAKYLEVLQGLTVQQHDNPSAFENVFEQTGPRALTGARLADAIRVDSEATVPRLPLESDAADLADVVDLFAGNGVISRKITAADIFYDLKAKLTPDQLAALKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0K2</accession>
    <name>A0A231H0K2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Di-/tripeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dtpT</name>
        <name evidence="10" type="ORF">B7C42_05579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42379">
        <property type="protein sequence ID" value="OXR42379"/>
        <property type="gene ID" value="B7C42_05579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="28"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="491" mass="52601" checksum="1ED019FE468EFB8C" modified="2017-10-25" version="1">MSRVEPVPGEQASPETRTIFGHPIGLVNLFGVELWERFSFYGMLTILGYYLYYSLIDGGLGLEKSTATGIVGAYGGLVYLSTVLGGWLADRVLGMERTVFYGGVVVMAGHIALAVLPGLTGVGVGLVLVALGSGALKANASSLLGTLYEKGDPRADGGFTLFYLGVNLGAFVGPLITGLLQTHLGFHYGFGAAAIGMALGLTQYVIFRRNLGTHGREVPNPLPRSQIGKVIAFVLVVAVVVAFAMWTGLVRLSNLSWVTTGVIAAVSILYFGLMLTSPKVVAVERVRVRAFIPLFIANAVFWSLFQQIFTVLAVYSDERMNWTLFGWTAPASWIGSEEPIWVIVLSPLFALMWTRLGTRAPTTPRKFAYGVMGMGASFLLFVPLAAFDDKTVPALLVFVILAGFAISELLLSPIGLAVTTQLAPEAFRAQMMALYFFSVGIGTSMSGVLSGFYDTSHEVAYFGITGLIAIAVGIIVYFIAPQVSRLMEGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Q6</accession>
    <name>A0A231H0Q6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42422">
        <property type="protein sequence ID" value="OXR42422"/>
        <property type="gene ID" value="B7C42_05623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14042" checksum="2390AECA114E263A" modified="2017-10-25" version="1">MSILFGIGLVIWFVSIAAMFLARALDDLRQQAFRASLGMCAVGSLLLAIGTPFVSGNSTAKNILVSGGFVVMATLCAYSVVIMRHRPATPPIPLPIPFTPPTDNPTDAPQPSSQDSQTRVPAAGSHPHDPSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Z5</accession>
    <name>A0A231H0Z5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42529">
        <property type="protein sequence ID" value="OXR42529"/>
        <property type="gene ID" value="B7C42_05305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="24320" checksum="C5056618AD8BBFDD" modified="2017-10-25" version="1">MNSTHRNPQDMRLLDALAANNSSTRLEAALALGTRPEPGFADALIERCGIEPDFFVRDMLTWALTRLPAQVTVPKLRAQLGSARPQARSQALHTLSKIGDRGAWPAITRELLHDADDDVARSAWRAAVVLVPDAEKQALADALATQFGRGDREVRSSLSRALVALGEIIEPVLRTAMTNPDPVVRAHARATEVLLRDPDAGFDLAIGEARRVRALGPDPAESTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H126</accession>
    <name>A0A231H126_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42565">
        <property type="protein sequence ID" value="OXR42565"/>
        <property type="gene ID" value="B7C42_05342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="28425" checksum="9A67D48F1F31CF9D" modified="2017-10-25" version="1">MADTGEANRPLAERYPGTEPVGWHGVTVHPMYSQRLGAETTVVRLVLHAAAPPPGLLGLGIGVSVIDGYVTLRGHRLPGVDVWSDALAEGTDLHLSGTGPAAAYTLTPVWMTATGAVESWTGNYGLVIERGAADSMLLRCSTGVGDPDFEELVVAMTVSVDAGGEQDRFRATLYHLGVEAHTRGDVDQARRMWRQAADLGHTAAAYDLGVLGYRTREFDEAQRWWRLAAEQGDSRAMAGLAEVLERRGDPDAARRWRAQAQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H154</accession>
    <name>A0A231H154_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42562">
        <property type="protein sequence ID" value="OXR42562"/>
        <property type="gene ID" value="B7C42_05339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="25850" checksum="4CEBE0797C0EE172" modified="2017-10-25" version="1">MQLSRTADAVSSVTDRLTTISPQPPVWVVLATAAVAAVVVLYRPVWRVLRTCVTIAHEIGHAVVAICTGRTLSGIRLHSDTSGVTVSRGKPRGFGMVLTTLAGYPAPSAVGLGFAILLGTGRQTLMLWILIAALVVLIVVIRNLFGFLAVICAGGAAFAVSWYGTAVWQGVFGYVVTWFLLFGGVRAVIELWQVSVRGDGSDADQLAWLTRIPARLWVLVFGLLTLAALAVGAGELLGIQLGGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H155</accession>
    <name>A0A231H155_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione transport system permease protein GsiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiC_2</name>
        <name evidence="7" type="ORF">B7C42_05363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42586">
        <property type="protein sequence ID" value="OXR42586"/>
        <property type="gene ID" value="B7C42_05363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="33949" checksum="CE8260A05F9EC79E" modified="2017-10-25" version="1">MTPMTRYVIVRVLQAIGVLWAAFTISFAVLFLLPSDPVQMAVDADPGVPPDPAAIAELRARYGLDRTVPEQYWTALTHAVRGDLGRSLNTGQSVTGALAQSIPSTLALAGLALLLAIVFGTALAVAASYTRRPWLRNLLTALPPIGAAMPTFWVGLLLLQLFSFRLRLVPAFGGTGFSGTILPAVTLAVPVGAVIAQVFYSGLATTWRQPFVDVAFAKGASRLWVQWRHVLRAAAGPALTVAGLWVGTVLAGSVVVETVFSRGGLGRLTQNAVLHQDIPVVQGIVLIAALAFVVVNLAVDLIYPLLDPRVAVAREKVGAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H161</accession>
    <name>A0A231H161_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42590">
        <property type="protein sequence ID" value="OXR42590"/>
        <property type="gene ID" value="B7C42_05367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="25433" checksum="7C3F8D63FF9AD856" modified="2017-10-25" version="1">MPRRERSRWRTAAAAIGDYIRHAPGTYIWLAILLVSTLVVRHLSPDQAETLLGNRSTNLHHLREDPVHVLISSAFWLAGGGWFGYAVSYTIFHAQAERWLGTLRWLAVVVIAHVGATYLSEGVLYWAIQHGYAPESAVNTLDYGVSYALAGVIAVLVYRIAKPWRYVYLLGVVVFYAIPVFSNRTFTDIGHFSAMVLGLACYPLTLGRRGVWDPEVAVRGLAGSVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H190</accession>
    <name>A0A231H190_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein LppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lppC_2</name>
        <name evidence="2" type="ORF">B7C42_05394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778190.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42616">
        <property type="protein sequence ID" value="OXR42616"/>
        <property type="gene ID" value="B7C42_05394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="183" mass="18839" checksum="500DC2E67E040C1F" modified="2017-10-25" version="1">MPDYSYNPYAALPQLPEFTLTSTDVTDGQPLGNEQVSGVFGAGGRDISPQLSWSGFPAETKSFAVTVYDPDAPTGSGFWHWAVADIPASVTSLESGAGSAGEGSEGGALPSGAVQLRNDGGFAGFVGAGPPPGHGYHRYFIVVHAVDVESLGIGADATPAYLGFNLFSHAIARATLVGTYEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1V4</accession>
    <name>A0A231H1V4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_05159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515992.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42821">
        <property type="protein sequence ID" value="OXR42821"/>
        <property type="gene ID" value="B7C42_05159"/>
    </dbReference>
    <dbReference type="GeneID" id="66723867"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="24461" checksum="D342E2F4BBCD3EEA" modified="2017-10-25" version="1">MTDLVDRMTSSRLSSEAMAPSKRGTRLPREARRAQLLAAASEVFVLRGYHAAGMDEISQCAGVSKPVLYQHFSSKLELYLAVLQNYIDALVSSVRQALRSTTDNRQRVRAAVAAYFDFVDHETQGFRLVFESDLTSEPQVQRRVEQATEACVDAVFDLVAHDSGLDPYRARILAVGLVGASQITARYWLEADRPIPKEEAVDTTVQLCWGGLSRVPLSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H253</accession>
    <name>A0A231H253_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778350.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42912">
        <property type="protein sequence ID" value="OXR42912"/>
        <property type="gene ID" value="B7C42_04798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="14883" checksum="EB348400864A80D9" modified="2017-10-25" version="1">MTSTAAARIDLSPSALEFVTERHLATLTTLRADGTPHVVAVGFTWDPEAGIARVITGGPTTKARNADRRGYAALSQVDGPRWLTLEGPAEVWTERDRVAEAEARYAERYRTPRENPQRVVIAVRVARVLSSSTLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2B4</accession>
    <name>A0A231H2B4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42989">
        <property type="protein sequence ID" value="OXR42989"/>
        <property type="gene ID" value="B7C42_04875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="237" mass="26465" checksum="D807BB40ED693CF9" modified="2017-10-25" version="1">MTTMRRFWIEFDPDENYDARFWRGAGVTGVDARDCLSMVAAQFSGGVLPTVHRITVDISLAEPLPGNPRFLGVPAWRGVWYPPVNLGTGPTRDIDRRGAPADYPTPVTASRGRARAGKTSPERFTWWDEIPQIDGLHWALVGMHCAEHRDGMRQFASALRNACAADPTLGLLVRDALDYMIAWRPTPEEWFDPTGIRFADQEALGEYLRAFRDYLLGDRAEPISPPEPETLPSGSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2C2</accession>
    <name>A0A231H2C2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778443.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42992">
        <property type="protein sequence ID" value="OXR42992"/>
        <property type="gene ID" value="B7C42_04878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="13555" checksum="0410ABE90A2AA4FA" modified="2017-10-25" version="1">MDRTNKQLVVDGFREFAAGNIDVLRTLLHENFIEHSPGNPSGRDDFIEFITTAPVAGAALELVRVIAEDDYVVLHYRMSPGGDEPDVAVVDIWRLEDGRIVEHWDVVQPVPEADQLPNGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2W3</accession>
    <name>A0A231H2W3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2Fe-2S ferredoxin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fdx5</name>
        <name evidence="2" type="ORF">B7C42_04598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43176">
        <property type="protein sequence ID" value="OXR43176"/>
        <property type="gene ID" value="B7C42_04598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="120" mass="13220" checksum="6165BDBEB5D35075" modified="2017-10-25" version="1">MIRVPVVRVDPAGFELAVGDGETLFEAALRVGARWPTICYGQARCTACAVRVIDGHDRLGPVSDEERDVLRQITNRRMGWPLRDTRLACRLTVTGDITVEKRAARPCAPGVSDSEERDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3J9</accession>
    <name>A0A231H3J9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol mannoside acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43459">
        <property type="protein sequence ID" value="OXR43459"/>
        <property type="gene ID" value="B7C42_04326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="36451" checksum="15317065E30398B1" modified="2017-10-25" version="1">MTQMRAALTDRAYAAGWRLVRGLPERTARRAFDFGGDWAARRANRAAHHGAGPNQLRRNLARVLAVDPLAVPDELIHASMRSYARYWREAFRLPTLDHAALADSPLMPPPDGLEHLDEALAQGRGVVFVLPHSGNWDMAGVWLVQHYGGLTTVAERLQPESLFERFVAYRESLGFEVFPLTGGEQPPFRQLAQRLRDNKVVCLMGERDLTGKGVPVEFFGERTWMPAGAAKLAIETGAALMPVHAWFTVDEQGREGWGLKTEAPLDVSAGVAAATQQLANRFAANIAEHPADWHMLQPLWERDLSAQRLERIAAAQAVRGDERSAGDAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H460</accession>
    <name>A0A231H460_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43733">
        <property type="protein sequence ID" value="OXR43733"/>
        <property type="gene ID" value="B7C42_03968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20166" checksum="E0432E050006D5ED" modified="2017-10-25" version="1">MADASHFDPPFVADREVYGSYSHRQLWELVHEALDPAALGEAAAAWQRQADAVAAAFRTFADTTHAEFERWSGHARAAAEPATAAFVERGAAAAEVCTRLGQLLEADAEAAQSIRDALPAPSNYVPLPDPVAEVVHGGARRMTHDIAAAAALADARDIMTFRYNTTLAASGDRVPRFVPAPRPDSGGGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4D3</accession>
    <name>A0A231H4D3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778861.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43680">
        <property type="protein sequence ID" value="OXR43680"/>
        <property type="gene ID" value="B7C42_04548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="19715" checksum="CC252E6358B519CB" modified="2017-10-25" version="1">MKTFVKLWAFVTAALLLIVAGLVWMIWALGDLLPPSWSWVRWLAPLGLFPLLFVASTGWAWRSARDGAAIRPDGNVYGELIVGGVATGAFGVLASGVAALFSGLEYLSKRRLSNAGGPLCGSDTMIAGDRCVQIPGGRVHQYGELAGQYWSASWQAHLAGNYFWVSVAVAVVSLALLVVTFFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4N0</accession>
    <name>A0A231H4N0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ferredoxin/ferredoxin--NADP reductase</fullName>
            <ecNumber evidence="13">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fprB_2</name>
        <name evidence="13" type="ORF">B7C42_04142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781076.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43903">
        <property type="protein sequence ID" value="OXR43903"/>
        <property type="gene ID" value="B7C42_04142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="296"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="470"/>
            <end position="472"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR43903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="555" mass="60352" checksum="2019B757CF07ADA0" modified="2017-10-25" version="1">MAYVITQRCCNDASCVPECPVDCIRPTPEQPEFATTEQLYIDPDTCIDCGACVDACPVEAIFSEDDLTASLARFRDINAAYFQRHPLESNFDPLVTPARPPKELGTLRVAIVGAGPAACYAADELLRRADVEVEMFDRLPTPWGLVRAGVAPDHPGTKSVSAMFESAFRRDTLQYRLNVEVGKHISHEELQAHHHAVIYAVGASTDRRLDVPGEDLPGSHSATEFVAWYNGHPDYAERSFDLSGERVVIVGNGNVALDVARVLTLSPDELAKTDIADHALDALRDSNIREVVVLGRRGPLQAAYTSAEFLALGHLKGVDVIIDPAELELDPASQALLDDPDIEPSLRLKYELAQEYAAKAPNPDNKRIVFRYLASPTEIRGEGHVAELEFVHNELVAEDGRVVARASDRRETLPASMVLRSIGYRGVPIADLPFDERAGIVPNEHGRVIADGAHVTGVYVSGWIKRGPRGVIGSNRVDATETVEQLLEDFTSGKLTAPQGDRAALEALLAQRQPDAVGRDGWKAIDAAEKSAGKSGGRPRVKFTTIEDLLKAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4V1</accession>
    <name>A0A231H4V1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43848">
        <property type="protein sequence ID" value="OXR43848"/>
        <property type="gene ID" value="B7C42_04083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="25773" checksum="E5F86C02C641B278" modified="2017-10-25" version="1">MCSKEYGRPYVYRNGRFLGTGWHTIDRMVVPEQQTAAESADQRLRRGARSRRAVTRRSIEIASVDGLDGLSFGRLADDLGVSKAGIQTLFRTKEALQLATVEAARELFVDTVVRPARDAPAGVARLRALVDEWIDYVQRPMFPGGCFLGANLPIFDSRPGPVRDALREQQRAWVALLTAQFRRAVAAGEIADVDPEVAGFEVAAVLNAVNVALRLGDDAAVGMARQVVDRLLGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H585</accession>
    <name>A0A231H585_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitomycin radical oxidase</fullName>
            <ecNumber evidence="4">1.5.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mcrA_1</name>
        <name evidence="4" type="ORF">B7C42_03587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44031">
        <property type="protein sequence ID" value="OXR44031"/>
        <property type="gene ID" value="B7C42_03587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="61"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="475" mass="48824" checksum="4B4CF6C7A78DC4B6" modified="2017-10-25" version="1">MTLPHEALRADSRPGGVGHRKDDAPGHFRDLDDLAAALSGALIRPTDAEWDQARAAWQLLADQRPIAVVTAATTEDVAFTVRAAAALGLRVAPQSIGHNATPLGDLARTILLRTGALDRVEIDADAGIAHVDAGARCADLTAAAAAAGLVPIGGFSADVGVVGLVLGGGLGWFARSHGPARASVLALELVTGDGVVRRVRAGDDLFDAALAGADIGVITTLTLRLHAIDDVVAGALFWPVESTRDIFHAWTTWTATMPETVTSVVRVLRFPDAPDVPPMFAGRAFAIVEAAIQADAATAHDLLAPLRELSPLVDTFDVVAPTALAGLHMDPPVPVPALGCSALLETLPAEVVDAVVTAVTTGPADTLTSVELRHLGGALDRAEASPTLGSAALLFAVAVVPAPAAAEAAAAGFEALTAAVAAVRSERDISSFTESATAPERLFGSDLPRLVAAKDRWDATDVIHANHSVRDPFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5D8</accession>
    <name>A0A231H5D8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43946">
        <property type="protein sequence ID" value="OXR43946"/>
        <property type="gene ID" value="B7C42_04185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="180" mass="19867" checksum="6ABDF52F2396BAF0" modified="2017-10-25" version="1">MPAAPYAALALGTDPASPPVGNSSDTAVAKGLSMRTLDLERIIRAPRADVFDWITDATNYQRVPAIRRVTPVRPGNVSEHGVGAVRLLVTPLLRLTEEVVDYDPPRLFRYRVLKSLPPLRRQDGTVTFDDHPEGTRVRWHSQFEVATPLFAAAWTLALIPAVYLGVSMVLSTAEAELRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5N1</accession>
    <name>A0A231H5N1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_1</name>
        <name evidence="2" type="ORF">B7C42_03764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44204">
        <property type="protein sequence ID" value="OXR44204"/>
        <property type="gene ID" value="B7C42_03764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="36867" checksum="247F28FEFB3C1A99" modified="2017-10-25" version="1">MSTTRRFGSTGMDITPVGFGTWVISGPGWQYSWGSTDDTDSVAAIRHAVATGLNWIDTAAAYGLGHAEELVGRALAGIPERERPYIFTKTGLIWEDGDDPNGPPLRVMRPETVRRELENSLRRLGTDHIDLYQVHWPDTGARFVYGAEGEPTGDATPLEEYWQLMADLRKEGKVRAVGLSNHDVRQLDIAESIAHVDAIQPPFSALNRVAAPEIAWAAAHDTGVIAYSPLQSGLLTGAYTADRVLAADDWRRGYAEFTTDLPVNLAFVDALRPIAARHGVGVAEVALAWVTGWPGITGAIVGARTPAQIDGWAGARDLVLTADDQAEITAALVATGAGTGPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5R9</accession>
    <name>A0A231H5R9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azoB_7</name>
        <name evidence="2" type="ORF">B7C42_03914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44353">
        <property type="protein sequence ID" value="OXR44353"/>
        <property type="gene ID" value="B7C42_03914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="33793" checksum="9D8067775B34C2B0" modified="2017-10-25" version="1">MTENTLSQNETLGTTTVFATADSDDPAAATTASLGLDRTDVGPVVVLGGTGKTGRRVVARLAERGIEARPASRSTAIPFDWADRTTWDAALHGARSVYLAYQPDLAAPGADEAVRALTAAARRAGVRRLVLLSGRGEPEAQRCEEIALRSGPATTVVRCSWFAQNFSEDFLAEEIAAGQVTLPADAVAEPFVDAEDIADVAVAALTEDGHAGEVYELTGPQALTFAEAVATIAAATGREIGYQPVSLEEYAAAMSEMGLPREVVDSLTYLFGTVLDGRNAAVTDGVERALGRPPRSFADYARRTAAEGGWPVADGEPSDAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5V8</accession>
    <name>A0A231H5V8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crt_5</name>
        <name evidence="3" type="ORF">B7C42_03182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44393">
        <property type="protein sequence ID" value="OXR44393"/>
        <property type="gene ID" value="B7C42_03182"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="PTHR43149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29055" checksum="0D0DA5928EA41EFB" modified="2017-10-25" version="1">MSDWKAFDVERTGHVARVTLTGPGKGNAMGPDFWSELPLIFGELDADPEIRAVVLTGSGKHFSYGLDLPAMSPTFGPLLGEKALAAPRTDFLYEIRRMQASVTAVADCRKPVIAAISGWCVGGGLDLIAAADIRLASAEASFSLREAKVAIVADIGSLHRLPGIIGEGHVRELAYTGKDIDAARAEKIGLINDVYPDQEAVLAAAHTLAEEIAANPPLVVQGIKDVLDQPKAGKVADGLRYVSAWNAAFLPSEDLTEAIQAVFEKRKPNFQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H641</accession>
    <name>A0A231H641_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaE1</name>
        <name evidence="10" type="ORF">B7C42_03725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777459.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44166">
        <property type="protein sequence ID" value="OXR44166"/>
        <property type="gene ID" value="B7C42_03725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="9">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1181" mass="129019" checksum="3CA4238C8032396F" modified="2017-10-25" version="1">MADSGFVHLHNHTEYSMLDGAAKITPLFKEAERLGMTAVGMTDHGNMYGASEFYNSAKKQGIKPIIGIEAYIAPESRFNTKRVQWGDPSQKSDDVSGSGAYTHMTMVAENATGLRNLFKLSSLASIEGQLGKWARMDAEIIAQHAEGIIATTGCPSGEVQTRLRLGHDREALEAAAKWQEIFGKDNFFLELMDHGLSIERRVREGLIEVGKKLGIPPLATNDCHYVHESDSTNHEALLCIQTGKTLSDPTRFKFDGSGYYLKSAAEMREIWDGEVPGACDNTVLIGERVQSYEDVWTHRDRMPKFPVPEGETEASWLRKEVARGLEYRFPDGVPQKYLDQAEYEINVILEMGFPAYFLVVGDLINHAREVGIRVGPGRGSAAGSLVAYALKITNIDPLPHGLLFERFLNPERVSMPDIDIDFDDRRRGEMVRYATEKWGSDRVAQVITFGTIKTKAALKDSARVLFGQPGFAIADQITKALPPPIMAKDISVSGITDPEHERYKEAAEVRTLIESNPDIAKIYDTAKGLEGLIRNAGVHACAVIMSSEPLTDAIPVWKRAQDGAIITGWDYPSCEAIGLLKMDFLGLRNLTVLGDAIDNAKANRGVDVDLDALPLDDPKTFELLARGDTLGVFQLDGGPMRDLLRRMQPTAFEDIVAVGALYRPGPMGMNAHNDYADRKNGRQEVKPIHPELEEPLKDILGETYGLIVYQEQIMHVAQKVAGYSLGRADILRRAMGKKKAEVLAAEFEGFEKGMLENGFSKAAIKALWDTILPFAGYAFNKSHAAAYGLVSYWTAYFKANYPAEYMAALLTSVGDDKDKAAVYLSDCRRLGITVLPPDVNESEQNFAPVGTDIRFGLGAVRNVGTNVVSSIIAARTEKSKFTDFSDYLNKIDTIACTKKVTESLIKAGAFDSLGHPRKGLLLVHSDAIDAVMATKKAEAIGQFDLFGGLDDGDDSISSVFDVKVPDEEWEAKHKLALEREMLGLYVSGHPLNGVEHVLAAQADTPIPAILQGDVKDGAQVTIGGILASVTRRVNKNGMPWASAQLEDLTGGIEVLFFPQAYSVYGMDIAEDAVVLVKARVSVRDDRISLIANDLVVPDLSSIGMEKPLAVTIPTRLCTPDKVSALKRVLSSHPGTADVHIRHIGSREKTTLLKVADNLRVSPSSALMGDLKALLGPGCLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6C7</accession>
    <name>A0A231H6C7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator TtgW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ttgW_1</name>
        <name evidence="6" type="ORF">B7C42_03263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775858.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44474">
        <property type="protein sequence ID" value="OXR44474"/>
        <property type="gene ID" value="B7C42_03263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="22266" checksum="C17C007679350F1E" modified="2017-10-25" version="1">MTKRRAETRQRLLDAAFDAFADEGFGRCTVEQICERAGFTRGAFYSNFSSLEELFLAMWELRSAEMLRELTGVLDSESGTDVHDLRAGVEQVLRAVPLDDKWFRITAEFTAHALRNPPLRRVMVARENAIVAALLPVLEALLNRAGRTVTDREGLGRAVVAVHDGTSQQCLLEPGDAAVREQRTTLFTHVAMAYSAARDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6E2</accession>
    <name>A0A231H6E2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">purM</name>
        <name evidence="15" type="ORF">B7C42_03383</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051024195.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44593">
        <property type="protein sequence ID" value="OXR44593"/>
        <property type="gene ID" value="B7C42_03383"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="77"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="193"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="372" mass="38575" checksum="D7D46D8114A8F5E0" modified="2017-10-25" version="1">MTEQTPSGAGVNDTGADEAQSGGASYAAAGVDIEAGDRAVELFAPLAKKASRPEVQGGLGGFAGLFALKGGYREPLLAASTDGVGTKIAVAQALDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGKVVPERVAQIVSGIAEGCIQAGCALLGGETAEHPGLMGADDYDISATGVGVVEADEVLGPDRVRPGDVVIAMGSSGLHSNGYSLARRVLLDIDRMALTGHVEEFGRTLGEELLEPTKIYAKDCLALIAETDVRTFAHVTGGGLANNLARVLPAGLVAEIDRGTWNPAPIFKLIAQRGRVERAEMEKTFNMGVGMVAVVAPEDADRALAVLTARHIECWTLGSVKKAKDADAARVALLGEHPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7J9</accession>
    <name>A0A231H7J9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH-type transcriptional regulator KipR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kipR_4</name>
        <name evidence="4" type="ORF">B7C42_02714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777208.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44760">
        <property type="protein sequence ID" value="OXR44760"/>
        <property type="gene ID" value="B7C42_02714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="211" mass="22010" checksum="F98B7AD87A28297A" modified="2017-10-25" version="1">MPAPDTSQTLSRGLDVLKLLASSPHARTPAQLAQELGLSRTIIYRLVGTLVEHGLVRRAEDGTVSVSAGALVLTQHVLGSVREATREILEELAREVEATAHFCVADGDDVLAVAVVEPPFTTFHVAYRVGARTARGQGALGEAIEASRRGERGIFESEGKLVPGAHGVVASLPGLPGPPAAVGVVTLVGQETPAMTDAVRRAAERLYTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7X0</accession>
    <name>A0A231H7X0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F420H(2)-dependent quinone reductase</fullName>
            <ecNumber evidence="3">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784200.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44938">
        <property type="protein sequence ID" value="OXR44938"/>
        <property type="gene ID" value="B7C42_02895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="16131" checksum="E37A21493F06F253" modified="2017-10-25" version="1">MADLFSTALRAHQWLYEKSDGYVGHRLLFGNPTLLLRTVGRKTGQPRTSALTYARDGEDYLVTASNGGSPRPPGWLANVKAAPECEIQVGHRRIPVTARPTYPDDSDYARRWTLVDKVNKGRYTQYQKMTDRPISVVVLSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8B2</accession>
    <name>A0A231H8B2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">snaA_1</name>
        <name evidence="2" type="ORF">B7C42_03035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45078">
        <property type="protein sequence ID" value="OXR45078"/>
        <property type="gene ID" value="B7C42_03035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="31744" checksum="F1E3F5BCEBD343C3" modified="2017-10-25" version="1">MELSLHYWNFSTPADSARTAGAIAETARVAEEGGFTEFTVMDHYFQMEHTGVAEEPMLEAYTTLGYVAALTERIRLAVLVTGVMYRYPGLLAKIVTTLDVLSGGRAQLGIGASWYEREQRGLGVPLVPMGERFERLEETLQICLQMWSDDNGPYRGTHYRLDETLCVPAPLSRPRPPILIGGGGEKKTLLLVARYADACNLFASSPEDVAHKLDVLRAHCAAEGRDYDAIRKTATYIGPVVNDPDAFVADAERYAALGITQFDIMPDRDPVEYAERAAELVPRLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8E5</accession>
    <name>A0A231H8E5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778780.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45080">
        <property type="protein sequence ID" value="OXR45080"/>
        <property type="gene ID" value="B7C42_03037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="20923" checksum="C476FDDA5B3C51BA" modified="2017-10-25" version="1">MTTSKEGVYVGPLHQLARGAWQSLLVIGLLSVIVGIIVLVWPGPTLAVAGILFGVYLLISGILQLVAAFGPHVSTGYRVLTLISGILSFILAFFAFRSIGNSLVLLGLWIGISWLFRGIAAMVAGAETPQGVPGRGWSIFFGILLLIGGIALVVWPIHSITVLALVVGWWLIFMGVMEMIYAVEVRSVAKKTPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8L2</accession>
    <name>A0A231H8L2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galK</name>
        <name evidence="11" type="ORF">B7C42_03023</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45066">
        <property type="protein sequence ID" value="OXR45066"/>
        <property type="gene ID" value="B7C42_03023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="10">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="8">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="9">
        <location>
            <begin position="273"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR45066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="368" mass="38308" checksum="5EE65C58D50D5227" modified="2017-10-25" version="1">MSATPGRGVWVAPGRVNIIGEHTDYNDGYALPIALPQVVTCTAEVTTDGAVRVSSKQHAGQVRESLDGLAESAVTGWARYPLGVVHEYLRRGHELSGVVLEIDGTVPVGAGLSSSAALECAVALAIRDLFGIDADSAELIDIGRAAENSYVGAATGTLDQSASLLCTAGHALFLDFATGDSAQVPFDLAAAGLQLLVADTDTPHRLADGGYGRRRRECEQAAHALGVHSLRAVTDPAAAERLADPVLRRRARHVVTENARVLTVVGLLRDGCDPRAIGPLLTSAHASLRDDFEVSTPELDAAVAAALDAGAHGARMVGGGFGGSIIAVTDIDRTDSIASAIRRRFRDDGFSPPRFFVAVPAAGARRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8M1</accession>
    <name>A0A231H8M1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-chlorobenzoate--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcbA2</name>
        <name evidence="2" type="ORF">B7C42_03118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.33" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45160">
        <property type="protein sequence ID" value="OXR45160"/>
        <property type="gene ID" value="B7C42_03118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018861">
        <property type="term" value="F:4-chlorobenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="42"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="437" mass="45944" checksum="C8F15FE0EC66FDD3" modified="2017-10-25" version="1">MTGEAVGRRSDAPSRVWTRCSPASGSTAMVSGFLWTLVVGRAASEAADRAMLIGESGECVSAKETVVRAERLAATLLGEGVRPGMRVAWQLTNSIDAVLVLLALARLGAVQVPLDAALTEKQTRSASEALHVEAFICRAPRSGGENAEGPKGRPLAGRLLITSPSPSEGRRAGVPLPPYRAADGNPQWLFSTFTSAGMVQSILHTDISLGTAARGLLANAQFDHVLRSATGAVVVPIAEVQGLIGLAAMLVLGAPVVLIEPHKPPHIVGVLREFDIGVVAASDDLCGSLLTLRRALPRGSDLVPKMRLLVVLGDVHTHEMDVGAERELGAVVCRAYGCPEVPVVCTGESVDVGRRRGSFMGIPISGVRARVTVGGLPVREGVHGDIEVSGAGVCSGYVETAHNYAAFTDDGWYRTGDRGRLTLDGRLQVFDSGRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8P0</accession>
    <name>A0A231H8P0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bkdC</name>
        <name evidence="8" type="ORF">B7C42_02354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45229">
        <property type="protein sequence ID" value="OXR45229"/>
        <property type="gene ID" value="B7C42_02354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="456" mass="48127" checksum="3AF96BE52EEFB20C" modified="2017-10-25" version="1">MDDDNHILEFRLPDLGEGLTEAELISWSVAVGDTVELNQTIAEVETAKAQVELPCPFAGQVAELLARPGETVAVGAPLIRVRTAAPAGDAPAAGESRTSVLVGYGPGAEAPTRRRPASKNGAATPHSAAPGRPEEIPPEFPGRPPATPAARQLARELGINIAFVAGSGPGGAVTVEDVRHAVPVSQPQRRVRTEDETTDAPRPAAPPVPAMRPDGGIIRPTPSERETRTPVNGVRKRIAAAMTTSARTIPQASAFVTTDFTASMELLDHLRSTDSFTGLSLTPLALVAKATLAAIAEFPGINSCWDAEANQIVTKHYVNLGIAVATERGLLVPNIKEAQWLSLRELCREIGWLADVARAGSATPADLRGGTFTISNVGVFGVDTGVPLVNPGEGAILCLGSIRKRPWVYRDEPAIRWITTLGVSFDHRMIDGELGARFLSTVASLLEDPLTLLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8W4</accession>
    <name>A0A231H8W4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdd</name>
        <name evidence="2" type="ORF">B7C42_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45305">
        <property type="protein sequence ID" value="OXR45305"/>
        <property type="gene ID" value="B7C42_02430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="13952" checksum="76C0AB68C9D6B0EA" modified="2017-10-25" version="1">MPEIDWDSLRHNAFRVMRHAYAPYSGFPVGAAALTAGGSIVSGCNVENVSYGLGVCAETVLVGNFCSSGGGRLLAIAVCDSHGEILMPCGRCRQVLYEHGGPELLVDHRDGPVPLARLLPDAFGPDDLAAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8X4</accession>
    <name>A0A231H8X4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">D-alanyl-D-alanine carboxypeptidase DacF</fullName>
            <ecNumber evidence="13">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dacF</name>
        <name evidence="13" type="ORF">B7C42_02440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45315">
        <property type="protein sequence ID" value="OXR45315"/>
        <property type="gene ID" value="B7C42_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013121988" evidence="11">
        <location>
            <begin position="41"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="12">
        <location>
            <begin position="110"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR45315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="437" mass="45263" checksum="3E707D911043C404" modified="2017-10-25" version="1">MNTRMSRTVRFRRSRALAAAVLTAGLLGATTVTGLDVADAAPAPPSTPFTTPNTDSCPNKTAPPPPIDTSEVPAPGSTTPSPLPVPSDPIGGDKLGRCGVVVPAGAPPLPADISATAWLVADLDTGKVLAAKDPHGRYRPASTIKTLLAAVALPALDPNQVVIGTQDDANADGTRVGIGPGGRYTNDQLFHALLMCSGNDAAHAIATQLGGDEATVAKMNAMAKQLRAMDTRAATPSGLDGPGMSTSAYDLATIFRHDMQNPTFASIIHTEQYDFPGYPANPTIPDDKDHPGFPIANDNHLLYDYDGDLGGKTGYTDDARQTFVTAAERGGHRLVVTLLKADVLPIRPPEQAARLLDYAFALPAGATIGSLPDRNTGEDSNTNVALASPPAHDTPTAAAPTTTHGNSNLRTIGIIGALGSAIALGLFGWSRMGRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Y9</accession>
    <name>A0A231H8Y9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45157">
        <property type="protein sequence ID" value="OXR45157"/>
        <property type="gene ID" value="B7C42_03115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="354" mass="38069" checksum="8EEBFF4A77515AC3" modified="2017-10-25" version="1">MEQDFLRGTSRKQNLTVEITAAVVVAVVVVAALVGIAINRHQKNRGDLVVGIELPYVAPGVAVGTHVIMHGVEVGSVTELTRIDDDALRMTMALNPSRTAGLTDSFAFDYRPENYFGVTAVDLQAGAGGERLTSGRTVVRKPIGDYSMSTMIEKGSLVVDGTLTNDVVTSLDKIVRYTNGLNPMIQTGIVFADRIAKTQQALPSESIGYFDSILDSLPAFDREFVAGLNGIFYTEYNRQADGSLGTNADLMDRNDVGLQLGATKLFGAAGHLLQSHKTELPPIVDAVQAMTDVIPDVLAHGSLTDRFRALIEQYNQAITGPDDAKKLNVRIALDRLPMLAAPFGVPALGMEKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H985</accession>
    <name>A0A231H985_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45415">
        <property type="protein sequence ID" value="OXR45415"/>
        <property type="gene ID" value="B7C42_02540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="35592" checksum="606439B5CD700FE4" modified="2017-10-25" version="1">MTRSEPDPQQDNPFDLGLPMVRTPVGKQGRKRRSGRRHPNRPAAAANHGAVAVAPARPGPEPAAYPSGEWEQWLQPAQRTTPEPEPDVEPEPRRIPVGGPLTDPDLVDKSTLVPHIVDRSGGNPGPALRRPRPRQAGPRRDHRRGEKLLAAITLIGVGIVVVSVVLTVLHTGKRSQPVATKPPMVAAVPVPTSVSATPPPPTTTAAATSTIATDGCEQQRTAEVVSGTDPGGTASGPDAILAFERAYYVQRSGYAARAVVADDSSVPPADQIQRGINQVPVGTRYCVQITRTGDEGQWEVRLTQQKPDEQPHAFTQIISTRAESGRTLITGIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9D5</accession>
    <name>A0A231H9D5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513429.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45468">
        <property type="protein sequence ID" value="OXR45468"/>
        <property type="gene ID" value="B7C42_02593"/>
    </dbReference>
    <dbReference type="GeneID" id="66718990"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="10907" checksum="221D80E2E6637265" modified="2017-10-25" version="1">MLYERTVLQELSDLLNGFHKDLQSEASNLQDCAAKLAQAWEGNAGLEAFQQSKQKWDQQFGDINGDSDPSTAMGKVSALSKAVAAAMNNATAADKVVANGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9N8</accession>
    <name>A0A231H9N8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator GlnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glnR</name>
        <name evidence="2" type="ORF">B7C42_02693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513346.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45568">
        <property type="protein sequence ID" value="OXR45568"/>
        <property type="gene ID" value="B7C42_02693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="14475" checksum="6B104672F3BC294A" modified="2017-10-25" version="1">MRIGELAERTDTSRRLLRYYEEQGLIRVRRCANGYRDYDERLVDQILHIRGLLDAGLPTRIIKQILPCLDDPRDIHFADATPEIIATLEHQRDRLTQRIDLLTRNRDAMTTYIGELRGCARPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Q1</accession>
    <name>A0A231H9Q1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lycopene beta cyclase</fullName>
            <ecNumber evidence="2">5.5.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crtL_2</name>
        <name evidence="2" type="ORF">B7C42_02685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.19" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45560">
        <property type="protein sequence ID" value="OXR45560"/>
        <property type="gene ID" value="B7C42_02685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="415" mass="45294" checksum="92D29F944217D474" modified="2017-10-25" version="1">MSAQDVRRADLCVVGLGPTGRAVAHRAMRAGLDVVAVDPRPERLWPPTFSCWVDELPAWLPHSAIAQRIEAPTVWTQTPHRIDRPYCVLSKPGLRDALPLDDATVLTGRATSVDAHRVGLQDGSTITATTVVDTRGLASPGSRRTASAHGIFVDADRAAPMIADGEGLLLDWRDENGAGPDEPPSFLYAVPLGDGTVIFEETSLGLRGGMPQHELRRRALHRLATHGVRLRGDEPSEAAHYPLDQPPPSMRRSSRGNDPVPFGSRGGMMHPCTGYSVADSFALVDTLVDAVRSGADPVAALWPWQARLVYWMRMRGVYGLGRLTTAQSISMFEAFFTASPRQQRALLSAHDDYAALGAVLFMTVSRTWPFRWRFDLVGWANRNRWVGYEYPAATSDPVLDATLDPAFPEDDSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9T1</accession>
    <name>A0A231H9T1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45714">
        <property type="protein sequence ID" value="OXR45714"/>
        <property type="gene ID" value="B7C42_02006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="15260" checksum="A7CE6F50A2576FEC" modified="2017-10-25" version="1">MSRNDDLLDIQQLLARYAVTITKGDIEGLVEVFASDGTYSAFGDTYTLDVFPELVAAAPKGLFMTGTPVLELDGDSASGTQTLCFVEHSTHDMRIGYYSDTYVRTEDGWRIKTRAMTFIRRSGDHDSGIPHAFDRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAT4</accession>
    <name>A0A231HAT4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAP_DH_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45939">
        <property type="protein sequence ID" value="OXR45939"/>
        <property type="gene ID" value="B7C42_02232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAP_DH_C" evidence="1">
        <location>
            <begin position="146"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="356" mass="37743" checksum="CC6536B7EEF061EE" modified="2017-10-25" version="1">MPIRVVHIGTGNVGRLALAGLIEDPRFELVGVCVSTKEKIGKDAGELAGLDVTTGIRATDEPAEMLALRPDCAVYCAMGDTRLLEALEDCRRILAAGVDIVGSAPGLLQYPWKVLPDKFFATIEAAAREGDASIFITGIDPGFANDLIPLAFAGTCRDIEQVRCSEIADYATYDGATVMFDVMGFGKPLDEVPMLLQPGVLGMAWGTTIRQLEAGLGITVDEITESYEREPAPESFDIAAGHVPEGSVAALRFEIRGMVKGRPVIVIEHTTRLRGDLRPDWPQPAQPGGSYRVEIVGEPSYTVDICPTSRHGDHNHAAIVAAAGRIVNAIPAVVGAPAGIRTALDLPLIAGNVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB19</accession>
    <name>A0A231HB19_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46070">
        <property type="protein sequence ID" value="OXR46070"/>
        <property type="gene ID" value="B7C42_01034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="45" mass="4713" checksum="B58905DE5892C9B0" modified="2017-10-25" version="1">MDSGSAAALEGIRQGYLNGDPVATALFIPLFFIAGIFGLIQGRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA5</accession>
    <name>A0A231HBA5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative heat shock protein HspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hspR_1</name>
        <name evidence="3" type="ORF">B7C42_01106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46141">
        <property type="protein sequence ID" value="OXR46141"/>
        <property type="gene ID" value="B7C42_01106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="14749" checksum="B930BBE34A765F30" modified="2017-10-25" version="1">MNGDPKNRATGTEYFMISVAAQLAGMHAQTLRTYDRLGLVTPQRTSGGGRRYSSRDVELLREVQRLSQDEGVNLAGIKRIIELTNQVEALQQRVGELTAEVDRLRAGHRPDLSPPQRSTALVVWQPRNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBX8</accession>
    <name>A0A231HBX8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46256">
        <property type="protein sequence ID" value="OXR46256"/>
        <property type="gene ID" value="B7C42_01222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="69"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="28982" checksum="5C24C3737D750FF9" modified="2017-10-25" version="1">MLRSDATGPRPRFARRATLRRSLRLLGSFRFEQTDPARFYGGIATDTADLVADFYRDLTGRDLRGTVVVDVGGGPGYFADEFAAAGARYLPIEPDPTEMHAAGLTVAGAVRGSGMALPIRDDAVDICLSSNVAEHVPQPWVMADEMLRITKPGGLMVLSYTVWLGPFGGHETGPWHYLGGEFAARRYTRRTGRQPKNRFGRSLFAVTAADGLRWARETGDRAQILATFPRYHPRWAWWVTRIPGVRELLVSNLVVVAAKPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBX9</accession>
    <name>A0A231HBX9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acrylyl-CoA reductase AcuI</fullName>
            <ecNumber evidence="2">1.3.1.84</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acuI</name>
        <name evidence="2" type="ORF">B7C42_01356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.84" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46390">
        <property type="protein sequence ID" value="OXR46390"/>
        <property type="gene ID" value="B7C42_01356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043957">
        <property type="term" value="F:acryloyl-CoA reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014188">
        <property type="entry name" value="Acrylyl-CoA_reductase_AcuI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF1">
        <property type="entry name" value="PTHR43677:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02823">
        <property type="entry name" value="oxido_YhdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="14"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="34393" checksum="3BD6BC90D08C6F16" modified="2017-10-25" version="1">MLGRMQFQAMVAHETDDGVVLAREEVGEDFLGPGTVTIKVHYSSANFKDGLAITPRGGVVRNYPIIPGIDLTGEVVASEDAAFTVGDLVIAHGYEIGVAHNGGFAEYARVPAEWVVKLEGLSPREAAALGTAGFTAAMSVQALLDRGLAPGDGPVLVTGATGGVGSVAVDILSGLGYEVTASTGKTDAGELLSTLGAAAVIGRLPEDPDAKPRPLGKAQWAGAVDSVGGKSLAHILSTVRYGGSVAVSGLTGGTELPTTVMPFILRGVGLLGIDSVNFPIDQRRALWARLGKDLKPRHLSTLENIAPVTEAEAVLHAIRGGHHSGRTVLAVAGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC14</accession>
    <name>A0A231HC14_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_2</name>
        <name evidence="3" type="ORF">B7C42_01325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46359">
        <property type="protein sequence ID" value="OXR46359"/>
        <property type="gene ID" value="B7C42_01325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="434"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="521" mass="56310" checksum="E50B4B9EBA0E6388" modified="2017-10-25" version="1">MTTGVQTDEPIRSRRNHWNNQIATHALMRPDAVAVRFRGQDTTWKQLHERSLKFADALARRGVGFGDRVLILALNYTEYLEAVFGINALGAIAVPVNFRLTPPEVAYIVADSGAAAIVTDSLLQPLATGVMAQSEALRTCVVIGGTTGEGVIGYDDFLAETGEPHVPQDIPEDTPALIMYTSGTTGSPKGAILSYANLNAQALTCIRAMNSTPDSIGFCTSPLFHIAGLGSLAPAFMLGSKTVLHPLGAFNATEFLDAIEAEQATTAFCVPAQWQLICEDPTVKERKLALETLSWGAAPASETVLRAMAECFPNAQNVAVFGQTEMSPITCVLEGKDALRKLGSVGKPIPTIQSRVVDDEMNDVAPGEIGEIVYRGPTMMQGYWNKPEATAEAFAGGWFHSGDLVRQDEEGFVWVVDRKKDMIISGGENIYCAEVENVLFAHPKIHEAAVVGRAHEKWGEVPVAVVALLDGETLTLEELTPFLNENLARYKHPKDLVIVPELPRNASGKVVKVQLRKDYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC75</accession>
    <name>A0A231HC75_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46445">
        <property type="protein sequence ID" value="OXR46445"/>
        <property type="gene ID" value="B7C42_01411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="125"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20188" checksum="77EFEE2286E5CB4A" modified="2017-10-25" version="1">MTVETDGGDATVALGVQDDAAAVDDRDEATEPDPTDAEEALIEEGEIAGDYLEQLLDVLDFDGDIDLDVEGDRAVVSIDGGRDLSKLVGRRGEVLDALQELTRLAVQQATGVRSRLMLDVAGWRAKRREELSALGTDAARRVAESGKPESLAAMTPFERKIVHDAVAAVDGVASESEGVEPNRHVVVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCX2</accession>
    <name>A0A231HCX2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46646">
        <property type="protein sequence ID" value="OXR46646"/>
        <property type="gene ID" value="B7C42_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="187" mass="19764" checksum="BA87129717CB94A0" modified="2017-10-25" version="1">MREFDTVVGLDLSLTSTGIARTTPGDPAVWCGTVKSAGAVGATWQQRYRRMSNIVGRILPGIPDGALVVMEAPAYSRTTGHQHDRSGLWWMVYDLLAGTTRTVVPVPPNSRAKYGTGKGNSGKDAVLAAAIRRYADVQISGNDEADAVILAAIGSRLLGKPIDDPLPQANLAAMDKITLPGGALIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDD2</accession>
    <name>A0A231HDD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46879">
        <property type="protein sequence ID" value="OXR46879"/>
        <property type="gene ID" value="B7C42_01858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="8323" checksum="7DA105A46BCBF21A" modified="2017-10-25" version="1">MVLFPVVLMLFALFMERVENRLRKLLEPGEEVQQYLDRASNAEVNELAKLGVPAHAGSGGRRRNRDELDVAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDH7</accession>
    <name>A0A231HDH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46929">
        <property type="protein sequence ID" value="OXR46929"/>
        <property type="gene ID" value="B7C42_00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15722" checksum="A0B12DF5AA8AD1BC" modified="2017-10-25" version="1">MSNSIAESTTIKATADKVRSTILDVEAYPTWQKEMLQVKIVDKDALGRPATVKFDISAMGQKASYTLVYSYPDEATIETHLTEGDAIVKQDQTYGITPVADGVELNYQLDMAVKWTVPDFMLKAIINKGIKGTLTGIKSRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDS7</accession>
    <name>A0A231HDS7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46918">
        <property type="protein sequence ID" value="OXR46918"/>
        <property type="gene ID" value="B7C42_00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="237" mass="25735" checksum="088A66CC68BC1C4E" modified="2017-10-25" version="1">MTTIVELAPVYAEATNPEFTIVQGIWNSRVQAEQRARAEGHEYLRPADGGVDREEIETLLARADAVILAPTTAAAAGMSQPTDGEEAGREIGHRLLDRLATDRPDLHIVLVSHFLVGHGVGHRNAKPNTWSLRAVEAHLRGGRNPWTILRPTWLSTLHDESYQTRLTQDQHADGLVSTHGLADAVLTAIERPELAAGRTAAVFNLSIPDTGSTDLAAQFAALRPDFEATRILEPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDV3</accession>
    <name>A0A231HDV3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47153">
        <property type="protein sequence ID" value="OXR47153"/>
        <property type="gene ID" value="B7C42_00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="18946" checksum="FAD11EF424662950" modified="2017-10-25" version="1">MKRTTFATWPCSVARTVDLIGDWWTPLVLREAFYGTTRFDDFERTLGLSRNVLTQRLTRLVEEQMLEKVPYQDRPVRHEYRLTDKGRDFFPVLTAMMRWGDRWLAPEAGPPVVVHHDTCGHDTHAEVVCAQCGEPLRHADVSARLGPGFPPQHRESAVRSGRFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDW3</accession>
    <name>A0A231HDW3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063013732.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47121">
        <property type="protein sequence ID" value="OXR47121"/>
        <property type="gene ID" value="B7C42_00243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="15682" checksum="A96349F913018AED" modified="2017-10-25" version="1">MDRYRHNALGETVLLGIGRELTIPGPTDGQEVPKFEVTLDAKEGHNVAATIAGDNGTVVQFFHDGTIAVGNDGRDIDEVRNLRREATRDRKRNGIGGSVTVTFTGNYRPRNLREADHYIEIPERTSPPSFRLYSDEFEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE06</accession>
    <name>A0A231HE06_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47171">
        <property type="protein sequence ID" value="OXR47171"/>
        <property type="gene ID" value="B7C42_00293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012308228" evidence="2">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="81" mass="7595" checksum="7C128C9B94FC5B95" modified="2017-10-25" version="1">MTSWAMCASITCAASNTRAMAPTGPESPGGGTDSLTASAAPATAPSRAPTSPKTAANSSTEAAKLCALAAAASAAGPCQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEN7</accession>
    <name>A0A231HEN7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="3 9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">tig</name>
        <name evidence="14" type="ORF">B7C42_00259</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777028.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47137">
        <property type="protein sequence ID" value="OXR47137"/>
        <property type="gene ID" value="B7C42_00259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_N" evidence="12">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="11">
        <location>
            <begin position="157"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger_C" evidence="13">
        <location>
            <begin position="258"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR47137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="459" mass="49929" checksum="74673A1E329072A1" modified="2017-10-25" version="1">MKSTVEQLSPTRVRINVEVPFEELKPDFDKAYRALAQQVRIPGFRPGKAPAKLLEARLGRGAILEQVVNDALPARYSEAVTASEVKVLGQPEIEITKIEDGDELAFTAEVDVRPEIALPDYESIEVTVDPLSIGDEDIDQQLQSLRQRFGTLKSVERAVQEGDFVSIDLSATVDGEEVSEATTSGLSHEVGSGQLIEGLDDTLIGLKAEESKDFTSTLVAGEHAGKEAVITVKVNSVKERELPEADDEFAQMASEFDTIDELKEDLRKRVEQSKKVQQAGEIRDKVLEALLDKTEVPLPEAAVQAEVDAVLHDAVHGFDHDEAKFAEALEAQGSTREEFDKDSKEAAEKSVKTQLLLDAIAESENTQVGQQELTERILFQSQRYGMAPEQFIQQIQQAGQLGAIFADVRRGKALAGVVIKAKVTDTDGNTVDTAEMFGEPAEAVADSEGAAESAENAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF45</accession>
    <name>A0A231HF45_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">kdpC</name>
        <name evidence="13" type="ORF">B7C42_00617</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47492">
        <property type="protein sequence ID" value="OXR47492"/>
        <property type="gene ID" value="B7C42_00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR47492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="32020" checksum="7AA0B94F6FC79C26" modified="2017-10-25" version="1">MPSFSMRYTTWFRQHLAAVRALLVLTAITGIVYPLAVFALAQLPGLHDRAEGSLVHRDGKLVGSSLIGQAFTDGKGAALPQYFQTRPSTSVPADGSRPDGYDPTNTAFGNKGPEDVLDSLAADPSQSTTGLLTTVCTRSKQIGEREGVSGARPFCTPGGVGAVLAVFGPRDGQGQVTAPTKVVSVNEACPAVPFQDAYRGVRVDCAQPGTDYSAGLIVPVRGDAPADTPVPSDAVTASGSGLDPHISPRYAQIQSARVAAARGITAEQVAAVVAAHTDGRDLGFLGEPRVDVLGVNLELDQRYPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFC7</accession>
    <name>A0A231HFC7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">crcB_2</name>
        <name evidence="9" type="synonym">crcB</name>
        <name evidence="11" type="ORF">B7C42_00707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042832.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47582">
        <property type="protein sequence ID" value="OXR47582"/>
        <property type="gene ID" value="B7C42_00707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR47582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18541" checksum="8706521AD1D2D8F1" modified="2017-10-25" version="1">MTELRREEPRPGASADRPVDPDIDLHVPSQRRELLREHGAVLAVIGLGGGLGGLARYGLTQLLPTRPGQFPWGTFTENVLGCLAIGVLMVLITEVWSAHRLVRPFLGVGFLGGFTTFSTYAVEIRNLLQPGSAVTAFVYLAATLLSALLAVLAGVTVTRMTVLRKVIRGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFG0</accession>
    <name>A0A231HFG0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4'-demethylrebeccamycin synthase</fullName>
            <ecNumber evidence="1">4.3.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rebG_1</name>
        <name evidence="1" type="ORF">B7C42_00815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.5" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47690">
        <property type="protein sequence ID" value="OXR47690"/>
        <property type="gene ID" value="B7C42_00815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="387" mass="40534" checksum="C25E40B862F5D896" modified="2017-10-25" version="1">MRVAVVAGPDPGHAFPAIALCLRFLQAGDDPVLFTSPRWFDAAREAGIAVRRLKGLAPRPQDDDADAGARIHDRAAHISSEILPDLSAMLPELVVSDVLTAGGGMAAERLGVPWVELSPHPLYLPSKALPPIGSGLAPGEGLRGRMRDTVLRGLTARAITRGDRQRGAARASVGLPELDPGPDARLIATLPALEVDRPDWPEDAHVVGPLLWEPTSEVLVPPPGDRPLVMVAPSTARTGFGDLAIGALEALADSDVRVAISMLDTPPQDLPPWATAGLGRQDELLRHAAVVVGGGGHGLLAKTLLAGVPIVTVPGGGDQWELANRAFRQGSSQLVRPFTPESLRAAVHTVLDDESYRKAAAAAAATASDVADPVDICHRTLDRARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFI1</accession>
    <name>A0A231HFI1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acyP</name>
        <name evidence="7" type="ORF">B7C42_00611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779854.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47486">
        <property type="protein sequence ID" value="OXR47486"/>
        <property type="gene ID" value="B7C42_00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="93" mass="10231" checksum="5413711D0836E462" modified="2017-10-25" version="1">MNPDPVRLSAWVHGYVQGVGFRWWTRARALELGVVGHARNTRDGRVHVVAEGPRPACERLLALLRSGDTPGRVDLVVENWGAALGGMTGFEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSM4</accession>
    <name>A0A231GSM4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000121">
        <property type="protein sequence ID" value="OXR39629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39629">
        <property type="protein sequence ID" value="OXR39629"/>
        <property type="gene ID" value="B7C42_08303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="28021" checksum="24E8A5D3D8A4AB2A" modified="2017-10-25" version="1">MDGERAGVDVADRVDQAHHPPGPAQVQSGDRGGPERVEVEERVSGQDALAVGDEPVVDLQLLVGGGVQFVPYVGAASGRAQPGDAQLGSESVGDGLEFVELVHVVAGHHDRDLEVLEPGVGEVAHGPHRGIERSGTAHRVVDLGGGAVDGDLHIHVIGGREPAGSFGGEPNPVGGELDSNMMGDRVVEQFPEVAAHGGFAAADVDVEDLHAFQLVDERLALGGRQLSWVAAARRGQAVLTRQIAGVGEFPGQADRGVEAVFEMFDQLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSW3</accession>
    <name>A0A231GSW3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000081">
        <property type="protein sequence ID" value="OXR39713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780510.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000081.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39713">
        <property type="protein sequence ID" value="OXR39713"/>
        <property type="gene ID" value="B7C42_08215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="13538" checksum="D77D0EFECC804A32" modified="2017-10-25" version="1">MNEEAHTEPGSRAMAYICVDLIATMTDIERAARQVAARLGYVYIGMTKSSSLIDPEVLPEHIRTHEVELLIVPDMAHLRGKVPPELAEVTDIHDLATGHTYEREGAYAPDQGHRPNPLATPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSW5</accession>
    <name>A0A231GSW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000093">
        <property type="protein sequence ID" value="OXR39672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39672">
        <property type="protein sequence ID" value="OXR39672"/>
        <property type="gene ID" value="B7C42_08261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9152" checksum="C1115C87415EA175" modified="2017-10-25" version="1">MRYMRVPVPPYGHATNRDAVSAVRRQYPGLTPVPATYNSPATPTGTGRSRRSRTNNAAPGTGEPIGGVPEPGANGGVKETHMVVSVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSY7</accession>
    <name>A0A231GSY7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000225">
        <property type="protein sequence ID" value="OXR39591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39591">
        <property type="protein sequence ID" value="OXR39591"/>
        <property type="gene ID" value="B7C42_08341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="57" mass="6390" checksum="89DC4702DF74C6AB" modified="2017-10-25" version="1">MLADFDNLRDYSGYLCGPPAMVEAAGRALKRRRMAPRRIFREKFTDAVTVGQELASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTF9</accession>
    <name>A0A231GTF9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000054">
        <property type="protein sequence ID" value="OXR39872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778610.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39872">
        <property type="protein sequence ID" value="OXR39872"/>
        <property type="gene ID" value="B7C42_08047"/>
    </dbReference>
    <dbReference type="GeneID" id="66719388"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="9641" checksum="4B9133B839967B15" modified="2017-10-25" version="1">MTMRPLDCEQCGQRVLIEKFSAAHTSVQWTGEAGRCPVIAAQGRGVGHQERGCDVLRRRIDRAVREHALPESRIQLPTGDDIPRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU88</accession>
    <name>A0A231GU88_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multifunctional conjugation protein TraI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">traI_1</name>
        <name evidence="3" type="ORF">B7C42_07776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000039">
        <property type="protein sequence ID" value="OXR40152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40152">
        <property type="protein sequence ID" value="OXR40152"/>
        <property type="gene ID" value="B7C42_07776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="2">
        <location>
            <begin position="11"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1375" mass="149837" checksum="F100AE8483B6E495" modified="2017-10-25" version="1">MTATLHKILAGTSYLYYQRQVAAADATDLGTSSLADYYSTRGEAPGTWHGTGLAALDISAGEQVTEDQMRCLFGLGRHPNATAIEYQVVTEAIAKGAKSKDAVHAAQHASRLGKAFPARHGDNPFRTRCAQAYREHNLSHGLDANAAIDEDTRARIRTEVAMAMFVENYDRAPLDDRELSGFVARISRPQSAAVAGFDITFSPVKSVSALWAIAPKPIADTIHAAHNAAVDDAIAWLETNATYTRLGTGGVRQVDVEGLIAARFTHRESRSGDPDLHTHMLIANRVRTLDGKWRTLDATHIYRNLVVVSEIYNTRLEHHLETSLGIGFTERPAPTPNKRPIREIIGIPAELIRHWSRRDAAIAHRLDTLAVSFQQQLGREPTPKELFALAERATLETRPAKHLSRSYAEQRHDWHSEAATLLGGPKAVEATVTSALNRSEHFRPTVDEAWISRTADEVVAVVSGQRSVWQHHHIRAETERQTRGHIYPTQWPNVVETVVREALSPTRSLARGDPDITVEPVLEHPPTIFQRRDGTSVYTVFGGQTYTSARRLGTEQRLLDLSVQPGARTLAADVIADAIHAYNTDPANNGRQLNPGQVAVVTEFASSPLRIAVANAPAGTGKTTAMRVLINAWHTSGGTVLGLAPTAAAAAVLAETTGIRVETVDRLLHILDQHAPGAQPITDSAYPPALPEWLLQLDARTLVVVDEHVKLGDDKRLRLFDFLTTRDATIRCLGDTAQLPSIDPGGTATDLTNSVTMTDVVRFADPREAAASFALRAGDPAGLGYYLDHQRIHSGTPAATADKAYMAWFADHHAGRDTLMLAPTHDLVTELNTRARTDRLTRTPTPAGPEVVVADGQCASIGDVICTRRNNPRLRLGGSDWVRNGYRWTVTVVHPDGSLTATHLSTGRHPGATTVLPADYVAEHVRLGYAMTIDSAQGVTTDTCHVALTGHESRNQFYVAMTRGIHTNHAYIPTTTDANEHSPWSEPAILPRTSTEVLQRILARDATHTSAHADLRDTLNPHKRLGRAIDTYHDAIGLAVENTLGPDALDQLDHAAEHLLPGLTDAPAYPVLRQHLATLAITGHDPVRALRQAASERELVTAHDPAAVLDWRLDTTGTHSTSAGPLPWTRAIPTELPDDVTQQLYARARIITTLVAHINTDAETWTPATAPPWARTLLENRDLTAQLAIWRAAHHIPDTDLRPTGPRRYPAAERHHQQHLDTRIIDTLGDLHTATHTWSPLAKRIDTRLTTDPWWPVLAQHLDTAADAGHDIETLLTTAANQRPLPDDMPAAALWHRLDLADRAPIEDAQTSVSEPDDNSVASSAGSAIDAAVASALPYDTADLIYEPDPNGEDQRHGPSPVAESARPPAIDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUN1</accession>
    <name>A0A231GUN1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.289</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wbbL_2</name>
        <name evidence="2" type="ORF">B7C42_07680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.289" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40255">
        <property type="protein sequence ID" value="OXR40255"/>
        <property type="gene ID" value="B7C42_07680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102096">
        <property type="term" value="F:decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="35623" checksum="0F8998FA940EAC7F" modified="2017-10-25" version="1">MSTLVAALGVVIVTYNNAADLPQCLDALQANASGAWVVVRDCGSSDQSVEIAERHPAVSRVIAGTNVGFGAACNEAVDSLGPDIQMVLFLNPDTAIDCDMADLLEYVTRFDEFGCVGIQQQSFDGDIVWSWDEFPTVPLEWRKARKLPLLQRSPAGYSEDRRVDWNMGAFLLIPRPAFELVDGFDEQFFLFYEEIDLQQRLARLGRPTYYVNKFHYQHDRSDKATLWREVLRLNSRRAYDRKWLTRLDTVQCQIAQSYRWIQDAIRPQRDRDRRLVIPRLLATWGLIHAVVPPENIEGGIDSWRSVRPFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVQ0</accession>
    <name>A0A231GVQ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40642">
        <property type="protein sequence ID" value="OXR40642"/>
        <property type="gene ID" value="B7C42_07327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="113"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="31674" checksum="2B3D680732AD980C" modified="2017-10-25" version="1">MASEGLPVQAACRLLDVAESGYYEWRSRPPSQRSIRHVWLLDQIRAVHAASRGTYGAHRVHAELTLGLGISVGHGQIELLMARAGIKGLPGNRRPKPRHQTPTAGDLVNRSFTRSQPNQLWVTDITEHHTREGKVYCAVVLDTFSRRVVGWSIDSTQTAALVTNALGMAIANRSPQAGTIIHSDHGVQFTSWAFTDRARKSGLVPSMGSIGDCYDNAVIESFWGRMQTELLNRQRWRTRIELANAIFEYLEIFHNRRRRHSALGMRSPIEYEMMQSPIQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVR4</accession>
    <name>A0A231GVR4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40571">
        <property type="protein sequence ID" value="OXR40571"/>
        <property type="gene ID" value="B7C42_07380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="52" mass="6009" checksum="5D203DBE4EFFD042" modified="2017-10-25" version="1">MYNWSLQDAIVAFVESQKPNWQAQHDLYLSVLYGFVDMQSHLLTLLGFPPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW75</accession>
    <name>A0A231GW75_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4189 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40741">
        <property type="protein sequence ID" value="OXR40741"/>
        <property type="gene ID" value="B7C42_07165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025240">
        <property type="entry name" value="DUF4189"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13827">
        <property type="entry name" value="DUF4189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556644" description="DUF4189 domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4189" evidence="2">
        <location>
            <begin position="35"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="15163" checksum="AD57DBF23A15FD5A" modified="2017-10-25" version="1">MMMKHTFTAGLLLTCAAIGTTALASAPAQADDVKWTAVAVSSSNGLLNASSNYTDVEEAKSTALANCDRRVPPPAGSSAPAHDCRLALVYPSGRCGAVATGTRYSDGDAVGTTYSWSVGSTLSDADFDAVLKNPGLGVTVWWSDCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW81</accession>
    <name>A0A231GW81_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40879">
        <property type="protein sequence ID" value="OXR40879"/>
        <property type="gene ID" value="B7C42_07014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="102" mass="10264" checksum="5B4E8E038E8239AE" modified="2017-10-25" version="1">MARARELLGADAALPVRLARPGAGYVVVAEILGAVSASRLAGAPGADPVTDHLDPPLPVVGVHEPFTVAAQRLSDATGPVVLARDGYAIALVDATDFDDAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWT5</accession>
    <name>A0A231GWT5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator MtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mtrA</name>
        <name evidence="5" type="ORF">B7C42_06805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515021.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41035">
        <property type="protein sequence ID" value="OXR41035"/>
        <property type="gene ID" value="B7C42_06805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="24860" checksum="C5EDADE2792B1F77" modified="2017-10-25" version="1">MKPKILVVDDDMALAEMLTIVLRGEGFDPHVVGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIVKPFKPKELVARVRARLRRTDDEPAELLSIADIVIDVPAHKVTRSGQQISLTPLEFDLLVALARKPRQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRAKVEKDPENPEIVLTVRGVGYKAGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWV4</accession>
    <name>A0A231GWV4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41068">
        <property type="protein sequence ID" value="OXR41068"/>
        <property type="gene ID" value="B7C42_06838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="14936" checksum="F46D923FBD50286E" modified="2017-10-25" version="1">MTDYLLRPIGSVESELTDRATPPRQADEGAPPAWVVLDDRYAEALEGLAPGMDLVLLTWLDRADRDTLTVHPRGDTSRPLSGVFSTRAPHRPNPIGLHEVRILSIAGTRIRVAHLEAFDGTPVLDIKPVLTASAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX23</accession>
    <name>A0A231GX23_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="5">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777891.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41164">
        <property type="protein sequence ID" value="OXR41164"/>
        <property type="gene ID" value="B7C42_06760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="458" mass="51540" checksum="770EB3EEFAC186F8" modified="2017-10-25" version="1">MYQPRTAVIGAGISGLTAGKMLGDYGVPYVCFESSDRVGGNWAFGNPNGHSSAYRSLHIDTSKHQLSFRDFPMPEEFPDFPHHTQIKQYLDEYCAAFDLYRSIEFGNGVEHARRLPGGGWELRTQRNEVRHFDFLVVANGHHWDPRYPEFPGEFTGRTMHAHHYIDPRTPMDFSDQRILVVGLGNSAADIAVELSSKALGNKLTLSTRSGAWIVPKYIAGKPADKYYRTSPYIPFSWQRKIAQWGQPLTAGRPENYGLPTPNHKFFEAHPTQSVELPLRLGSGDVIPKPNIDRFDGATVHFADGTADDFDIIIYATGYNITFPFFDPEFISAPDNKIDLYKRMFLPGIEDLAFAGFAQSTPTLFPFVECQARLIGAYAVGRYRLPSAEEMRRVIVAEQQHYTGHMVPSARHTQQVDYFLYEHDMRAREIPAGAERARLAGPPPWARVAQADRPVGVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXC8</accession>
    <name>A0A231GXC8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41270">
        <property type="protein sequence ID" value="OXR41270"/>
        <property type="gene ID" value="B7C42_06668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="55"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="36922" checksum="4A254E57BF12B9D3" modified="2017-10-25" version="1">MGRIAERAPKWKWRGRLPMRERNRVRVGVVGTLLVVIVLAVVFEYRSIPGVSDNSNYRAEFADASGLAVKDDVQVAGVVVGRVKSVELSGDRVEVEFTADTHGVRLGADTRAAIRVGTLLGKRYIELAPEGQGTLAAGATIPLQRTTSGYDVSRSLAEVSDTVAKTDKTRLSDALNQAGALLKTVSPDLESSLTGITRLSNTVASRDQAIDDLLAHANGVSGILSQRNEQFALLLADGRSLFAALNTRADEIHRVLVQAKSVFDELSALAQENTASIGPTLTELGTTVETLNKNYKNVSDSISGLRTFVTQLSDVVASGPFFNVLLDNITPATLNNPQPSNSGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXH1</accession>
    <name>A0A231GXH1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigE</name>
        <name evidence="8" type="ORF">B7C42_06476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41333">
        <property type="protein sequence ID" value="OXR41333"/>
        <property type="gene ID" value="B7C42_06476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="137"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="236"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="33881" checksum="07DDD701AC798002" modified="2017-10-25" version="1">MTKQGPADRRTAPGNTGLRFGVVPGTRRPPVVVRLPRSRVGGHPIHKVDAAREYATLPESSLPIGVSTDYELPGAARSDVRTEADVRTEAGADVLNGTDFDDTEAVAGDAADDDALSGTAAFDATGDRTMMPSWDELVREHADRVYRLAYRLTGDPQDAEDLTQETFIRVFRSLQNYQPGTFEGWLHRITTNLFLDMVRRRNRIRMEALPEDYDRVPSEGPGPEQVYHDARLDPDLQRALDALAPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQALREYLAHNGSQQRFAAEEKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXP2</accession>
    <name>A0A231GXP2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_26</name>
        <name evidence="5" type="ORF">B7C42_06478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780498.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41335">
        <property type="protein sequence ID" value="OXR41335"/>
        <property type="gene ID" value="B7C42_06478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041484">
        <property type="entry name" value="TetR_C_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17933">
        <property type="entry name" value="TetR_C_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="217" mass="23384" checksum="CAC55D4D8543E96F" modified="2017-10-25" version="1">MFKGAAVPEGSASDLSTPARIRDAAIVVFGEEGFGVGVRAIAKAAGVSPGLVNHHFGSKDGLREACDEHVRAVIRAAKTEYVQQPSPNSTLKALADIEEFAPYTAYLMRSFQAGGTLMTSLFDQMRADVESYLEVGIAAGTLRRPRDVSATANYLAVQNGGGFFFFLQLYAARHEGKLDFRQALREYADQMMLPAVEANTHGLFADSSVLDSLLAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXP4</accession>
    <name>A0A231GXP4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
            <ecNumber evidence="3">3.5.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41403">
        <property type="protein sequence ID" value="OXR41403"/>
        <property type="gene ID" value="B7C42_06546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="372" mass="38754" checksum="D67883E548DF25B9" modified="2017-10-25" version="1">MQPQQPPLRDVPESAEPLRPTASAPAEPNSHDGAGALVSDESDTADAPGTARPDAGTSTADPIGSPVPIVITYSTTAEAGRPAPAVAGGLESRPAARPAPAPAPAQAVDIAVVQFGPYTDKAANLAALRDHVRAAAEHGAKVVVAPEYSMFAVKRLDERVVAAAEPITGPWVSELRGLAAEFGVHVVAGVVEAPGGQITDRIYNTLIAAGPDAEFAAVYRKVHLYDAFGFRESEVVAPGPIEDPATFTVDGVTFGLQTCFDLRFPEGCRRVATAGAQVLLLPAQWIPGPGKLDQWTTLLRARAIENTVYVAAADHCAPRGAGASMIVDPSGNLLAELGDAPGIATSRVDLDHLRQIRTTNPSLSLRRFTVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXQ7</accession>
    <name>A0A231GXQ7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase DeaD</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cold-shock DEAD box protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">deaD_2</name>
        <name evidence="6" type="synonym">csdA</name>
        <name evidence="6" type="synonym">deaD</name>
        <name evidence="13" type="ORF">B7C42_06547</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41404">
        <property type="protein sequence ID" value="OXR41404"/>
        <property type="gene ID" value="B7C42_06547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070417">
        <property type="term" value="P:cellular response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12499">
        <property type="entry name" value="RRM_EcCsdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00964">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034415">
        <property type="entry name" value="CsdA_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028618">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="12">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="76"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="271"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR41404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="616" mass="67508" checksum="7F27790A27E3911E" modified="2017-10-25" version="1">MNNSSVDSVPGGGGDRPEGADERNHEGPADAATGYPGDSGDVTEPSFADLGIDDRLLAAIADVGYESPSPIQAATIPPLLAGADVVGLAQTGTGKTAAFAIPILMGLDKRPKPPQALVLAPTRELAIQVAEAFGRYSAHLPGIHVLPIYGGQNYAVQLQGLRRGAQVVVGTPGRVIDHLERGTLDLTQLRYLVLDEADEMLKMGFQEDVERILRDTPAEKQVALFSATMPSVIRKISKQYLKDPVEITVKSKTSTNTNITQRWVHVSHQRKLDALTRILEVEPFEAMIIFVRTKQATEELAEKLRARGYSAAAINGDIAQNQRERTIGQLKSGTLDILVATDVAARGLDVDRISHVVNYDIPHDTESYVHRIGRTGRAGRTGEALLFVAPRERRLLDAIERATRQPLTEMQLPSVDDVNAQRVVKFHDAITENLSSSNLALFRKLIEDYEAEHNIPLADIAAALAVGGHDGDNFFMEAEPEPIRPARRERAPREDRERRPEGGPQRHRATDAEMATYRIAVGKRHRVVPGAIVGAIANEGGLRRSDFGHISIRPDHSLVELPADLSSETLDALRRTRISGVLIQLQLDQGPPSHRSLSRGPRREGPRKYDRRKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXR7</accession>
    <name>A0A231GXR7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780406.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41400">
        <property type="protein sequence ID" value="OXR41400"/>
        <property type="gene ID" value="B7C42_06543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="27229" checksum="3435F5D6EE1191E0" modified="2017-10-25" version="1">MKWTLTPDQFAMAWQRIDGDRIPYPLAVRSSARDSAERAAQLPELTEWCDRTVDPDLEAALRLLARPTVCVEVFGECGAEEARPVRVLGAAAGHITVVAAQRHGDAADRGGDVRLFVGNSASLAARVVSLLPEYPAGSEPRRTAPLDRVREDSRDLVTVPVAGPSTTARMRRLLKQPRDGIGQIVVSARRADDSVRPLGVLCWIDVAGDGRYAVRTRADVDIVGVTAETFAAQLRPMVAAAERVVADDNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXT9</accession>
    <name>A0A231GXT9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41398">
        <property type="protein sequence ID" value="OXR41398"/>
        <property type="gene ID" value="B7C42_06541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="15071" checksum="7737E6861B6DA649" modified="2017-10-25" version="1">MQSQEAGDLRNDVGALVQAVDDGELWIDGVLVGDGTHERCARRYESLADQVEQQIRTLAAATSLPGFGGFESGHSLRRGFEGKAADAVDRLREYADAARQLAQTLRAAAAAYAQHDADAAAAIGKAAPPPPVVVAPSQPVGVGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYE6</accession>
    <name>A0A231GYE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783610.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41592">
        <property type="protein sequence ID" value="OXR41592"/>
        <property type="gene ID" value="B7C42_06233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="7272" checksum="945AC5F563AE216F" modified="2017-10-25" version="1">MTFGGATVDTATEYVITQLESAGSAERHDFDVPALVANLHALTEGWDFHLVNRSMFWSLAAGYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYI0</accession>
    <name>A0A231GYI0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase NlhH</fullName>
            <ecNumber evidence="4">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nlhH_4</name>
        <name evidence="4" type="ORF">B7C42_06222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41581">
        <property type="protein sequence ID" value="OXR41581"/>
        <property type="gene ID" value="B7C42_06222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="117"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="351" mass="37740" checksum="B0835BAC1A10FABE" modified="2017-10-25" version="1">MRASFRILTTAIQAAGARALSMPSAWWSLLALERPVVDGQQLSPRLQVLATLGKRELLARRPPSPATRARFDVLTRIAGGVDHTDVAVSTIQLSGPAGPLSARLYEPTELRRPCGLLVYVHGGGWHLGSAAGFDAPARLLATRARVKVLSVDYRLAPEHPFPAAFDDVLAAYRFAVDHAPDWNVDRTRIAIGGDSAGGNLAAATALHLGANSRYRPALAVLLYPVVDTSMAGYRSSDLFTVPLDRGCVERALAWYAPDPHTALDPRVCVLHAPNVNRMPATHIATAGMDVLRDQGEALAHRLGDLAVPVSLERYDNLPHGFATMLADPDARAATEDIADTVHARIGEPQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYL0</accession>
    <name>A0A231GYL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41688">
        <property type="protein sequence ID" value="OXR41688"/>
        <property type="gene ID" value="B7C42_06329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="11300" checksum="511CBD1A23F221C2" modified="2017-10-25" version="1">MEYAWWIGIHSFLARAEVAPWEVMEVLYSSRRWPRPARTPEGLPVTTVWGRTDAGRPLVVMLRMRPSPESAGTWEIVMAAQMRPQQLEEYTAWEANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYV4</accession>
    <name>A0A231GYV4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41786">
        <property type="protein sequence ID" value="OXR41786"/>
        <property type="gene ID" value="B7C42_06128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="102" mass="11027" checksum="633EF64F84478650" modified="2017-10-25" version="1">MFRLVELLGLCAPVLGAAIVLYYRRRLGRAFGSAVLAAVVAMIGSVIGLVTSRAMWFGSGGAEGMTQRMEFGAGVRNLLLVLAWALLLVAIRRRPARPEQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ30</accession>
    <name>A0A231GZ30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41835">
        <property type="protein sequence ID" value="OXR41835"/>
        <property type="gene ID" value="B7C42_06177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="55" mass="5980" checksum="D992E06012602A0D" modified="2017-10-25" version="1">MPNLPAGRSRWFAAASSARGVPARITFRPTRTHAWGYRQDALHDSWPGFAAAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ42</accession>
    <name>A0A231GZ42_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41877">
        <property type="protein sequence ID" value="OXR41877"/>
        <property type="gene ID" value="B7C42_05861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT_2" evidence="2">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="27024" checksum="FB1E7A23A9311479" modified="2017-10-25" version="1">MLVPAAVATFRPHAAPPAPEPPRGTAAGIPEPVLAAYRNAELILARSQPDCGLTWNLLAGIGRAESGHARSGDVDDRGRTHSPILGPALDGTLPGNEIIRSSSGYVRAVGPMQFLPSTWQRWASDGNGDGIADPDNVYDAALAAGRYLCAGGADLREPEQRLQAVLRYNHSMSYASTVLTWSHIYAGEAGSAPELSAPQPDTSSDPAATGDPAPSENDESSTATVPEDAPSTPAPAPAPGPMIYIPGLPPIPCGIFCPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ78</accession>
    <name>A0A231GZ78_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-(Acetamidomethylene)succinate hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.29" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41907">
        <property type="protein sequence ID" value="OXR41907"/>
        <property type="gene ID" value="B7C42_05891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047411">
        <property type="term" value="F:2-(acetamidomethylene)succinate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="31742" checksum="C8618385A64FF7F3" modified="2017-10-25" version="1">MPAPATVVRLPGDGVTLVADHWRADGDAPGTVMLLHGGGQTRHSWQRTGARLAENGWHALAVDARGHGDSDWAADGDYAITAHARDVVAAAGSLAGPVALVGASMGGLAALVAQGDHPRLARALVLVDITPKSEPAGVDRITAFMRDGLAGFDSLDAAADAVAAYNPHRRRPPRPDGLRKNLRLRDNRWYWHWDPRILSERDNGPERAGAREQWARDAARRISVPTLLLRGDRSDVVGDDGVRDLLALIPGARHIDVAGAGHMVGGDDNDVLTGGLLEFLTDTVANPRHHTGTGYHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZY8</accession>
    <name>A0A231GZY8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-CoA dehydrogenase fadE25</fullName>
            <ecNumber evidence="8">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_05758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42159">
        <property type="protein sequence ID" value="OXR42159"/>
        <property type="gene ID" value="B7C42_05758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="217"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="478"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="584"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="733" mass="77490" checksum="8DD046225E00CFB6" modified="2017-10-25" version="1">MPLALTADQAALAQAVSGFADRHHTREYTRKHTDRLAAGELPTFWADLVALGLPGVHLPEEQGGQGGTLDEMAVVLAESGRALLPGPLLPSVITSAIVASAESVAVVSDTLWRFAEGGTGATVDAGHGVRFAEAGSSGETGPVLGAAAADVLVVAAADGDRIRWFLVERDAPGVQIETCAGSDLGRDLAVVRLRDVAGIELTGIDTGYAEAVATAFMAAEAAGVIRWCSDTATEYIKARKQFGRPVGSFQAVQHRAAQLLITSELATSAAWDAVRGLADDPAQRTHAAAGAALTTLGNAVHAAVECLCLHGAIGFTWEHDLHLYWRRAMSLAGLGGSAESWERRLGEVALGGPRTFAVPLPETDSSFRTWVSEILDRAAALDNPTPGKIGDHDATNTGPRRTLLADSGLVSPPMPKPWGIEAGPLEQLILQDEYDRHAIAQPSMGIGQWVVPIVLQRGTPEQLARLAAPALRGEEIWCQLMSEPEAGSDVASLSLRATRDGDGWRLNGQKIWTTLAHRCDWGLLLARTDPEAERHRGLTMFLVDMHGAGVTVRPITQSSGQAEFNEVFFDDAFVGDDMVLGEVGQGWALTLETLAQERLFIGGVRDPGHNSRIVGIIERGEYAGSRENALRVLGRISARGATISAMNLRETIRRLGGHGIGPATSISKAAASMLHTDAAAAALELIGPAAALNEKDCEVVLHELDIPSWVIGGGTLEIQLNTIATLVMGLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H002</accession>
    <name>A0A231H002_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase isoenzymes formation protein HypD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypD</name>
        <name evidence="3" type="ORF">B7C42_05778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42179">
        <property type="protein sequence ID" value="OXR42179"/>
        <property type="gene ID" value="B7C42_05778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="370" mass="40868" checksum="66DFE13C9A707D3E" modified="2017-10-25" version="1">MKYLDEFSNPDLAQRLLDRIRTESTRRWSIMEVCGGQTHSIIRHGIDQLLPDTIEMIHGPGCPVCVTPLEIIDKALEIAARPEVIFCSFGDMLRVPGSSKDLFRIKSEGGDVRVVYSPLDALTLAKQNPDRQVVFFGIGFETTAPANAMTVYQARRLGIENFSLLVSHVLVPPAIAAIMESPDCRVQAFLAAGHVCAVMGIGEYPPLARKYRVPMVVTGFEPLDILEGIRRTVIQLEHGRYEVENAYPRAVPAEGNPAAKAMLEDVFEVTDRGWRGIGVIPRSGWRLSPRYRDYDAEYRFSVGDIHTAESSVCRSGEVLQGLIKPTDCAAFGTRCTPRNPLGATMVSSEGACAAYYLYRRLDLPAEVAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H033</accession>
    <name>A0A231H033_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ilvD_2</name>
        <name evidence="15" type="synonym">ilvD</name>
        <name evidence="17" type="ORF">B7C42_05813</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42214">
        <property type="protein sequence ID" value="OXR42214"/>
        <property type="gene ID" value="B7C42_05813"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="563" mass="58627" checksum="EC08787936A6B34E" modified="2017-10-25" version="1">MAHDRDTAHDIKPRSRDVTDGLEKTAARGMLRAVGMGDDDWAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVHAGGGYPLEFGTISVSDGISMGHEGMHFSLVSREIIADSVETVMMAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSTLPGNVDGRDVTIIDAFEAVGACMKGLISREDVDRIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPPAPDRRRDEYARKSGEAVVGLLRSGITARDILTREAFENAITVVMALGGSTNAVLHLLAIAREAGVELTLADFNRVGDKVPHLGDLKPFGRYVMNDVDRVGGIPVVMKALLDAGLLHGDVLTVTGATMAENLAHIELGLDGDVIRPLDRPIHKTGGLTILHGTLAPEGAVVKSAGFDSDVFRGTARVFDGERAAMDALEDGTIGAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHVAPEAVDGGPIAFVADGDPIVLDVANRILDVEIDEAELDARKVGWEPLPPKYTSGVLAKYRKLVSSAAHGAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H060</accession>
    <name>A0A231H060_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aliphatic sulfonates import ATP-binding protein SsuB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssuB_2</name>
        <name evidence="5" type="ORF">B7C42_05843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779753.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42244">
        <property type="protein sequence ID" value="OXR42244"/>
        <property type="gene ID" value="B7C42_05843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="27262" checksum="A8F3873D89539C9A" modified="2017-10-25" version="1">MTAVDEPRTATPLAVHITGLRKAFGDKIVLDGVDLSIRRGEFVVLLGPSGTGKTTLLRLLTGLEAPDAGEVLVPAVRTTVYQEPRLIPSKRVLANVVVGQRRSKPVREAGLRALAEVGLDEKARQWPATLSGGEAQRAALARALVREPELLLLDEPFAALDALTRLQMQDLVGDLVERHRPAVLMVTHDVDEAVRLADRVLVLNRGRFAVDIDIDLPRPRDRTDPAALRYQAALLAELGVGHTTDHHRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0A0</accession>
    <name>A0A231H0A0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">xseA</name>
        <name evidence="10" type="ORF">B7C42_05479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42280">
        <property type="protein sequence ID" value="OXR42280"/>
        <property type="gene ID" value="B7C42_05479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="9">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="8">
        <location>
            <begin position="152"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="455" mass="48786" checksum="A8F70DE8D6A5070D" modified="2017-10-25" version="1">MTDSHADAPAAGARASGEPARSAARPANSAEQPWPVRTIAMKVAQWIDRLGSVWVEGQITQINLRPGTRTAFLVLRDTAADMSLSITCDPQLLRASAVPLQEGSRVVVYGKLSYFTGRGTISLRVTEIRPVGIGELLARIERLKALLAAEGLFDPRLKRPMPFLPKVIGLITGRASAAEHDVVTVAQQRWPAVRFEIRNTAVQGATAVPQILDALAELNDHPEVEVIVLARGGGSVEDLLPFSDETLCRAIVSATTPIVSAIGHEPDNPLSDYVADLRAATPTDAAKRLVPDAAAELAGVRELRARSAAALRGWVDREARALQQLRSRPVLADPLRILDQRHDEIERLRTAAHRAVEHCLTSQATTARHLRDKLTAVGPAATLARGYAVVQRVTGTERHVVRTVADSPPGTQLRIRVADGAISAAALGSQALANPIPAQRVTDRPAPASEQEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B9</accession>
    <name>A0A231H0B9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ORF">B7C42_05499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42300">
        <property type="protein sequence ID" value="OXR42300"/>
        <property type="gene ID" value="B7C42_05499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="29840" checksum="EDF4226758D46127" modified="2017-10-25" version="1">MAAVKLASRVLSGKVRNLPYRIYEAQLSKQLAGKQHPRHVAVVCDGNRRWARENGFTDVTHGHRVGALKIAELVGWCQAEGIEMVTVYLLSTENLSRSADELETLFEVITDVVEELSAPENNWGVRIVGSLKGLPEDVARRMEKAADETHGRAGVHVNVAIGYGGRQEIADAVRSLVRQEIAAGETGEDLVQSITVNAIGQHLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEIWFTEAYWPEFRRVDFLRALRDYAARHRRYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0H4</accession>
    <name>A0A231H0H4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780632.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42343">
        <property type="protein sequence ID" value="OXR42343"/>
        <property type="gene ID" value="B7C42_05542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="12008" checksum="E812C24029B0C0B6" modified="2017-10-25" version="1">MALNHPSRDRIRVEQVLAALGHPTRLGAVRVLDGGGEFNCTSVLNTLGIHAKSTMTHHWRVLREAGVIRQTPSGREYLVELRRADLDTRYPGLLDAVLAGARDDGRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1N9</accession>
    <name>A0A231H1N9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_062963520.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42752">
        <property type="protein sequence ID" value="OXR42752"/>
        <property type="gene ID" value="B7C42_05090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="7160" checksum="942ADB8F9BF820E2" modified="2017-10-25" version="1">MELSTDYLIVVMAHSAPTRPLTVERAHQVMQLHTDCSTDGCGIKQAAFDALVTAGHIVPDSCRHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Q8</accession>
    <name>A0A231H1Q8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42784">
        <property type="protein sequence ID" value="OXR42784"/>
        <property type="gene ID" value="B7C42_05122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868">
        <property type="entry name" value="PTHR35868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="36379" checksum="51D9E15E263D8DFB" modified="2017-10-25" version="1">MAEWVTAEREITASVDLCTPRGRLNPDAVGWTRRPLHRANLRGWGRTKRWEYWGIVTPDHIIGIVLTSLDYAGLQGIYLFDRANGTEIVKDVVTPFARGVHLPDRSGVGTASGHAGDLIIELRNDPGGTRIHAATPRIDIDLTAGLPAGHESLGVVVPWSAGRFQYTVKDLGRPVSGTLTVDGIAYVIDDGFAVLDHGRGKWPYSIAWNWAAGCGRETAIQLGGRWTDGTGATENALFVSGRLHKIGDELEWVYDRRDWLRPWQIRGPRVAVEFTPFHVRESRTALGVLSNDTHQCFGHFTGRARTDDGDWVELDGLTGWAEEARNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2J7</accession>
    <name>A0A231H2J7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecBCD enzyme subunit RecB</fullName>
            <ecNumber evidence="8">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Exonuclease V subunit RecB</fullName>
            <shortName evidence="8">ExoV subunit RecB</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Helicase/nuclease RecBCD subunit RecB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">recB</name>
        <name evidence="13" type="ORF">B7C42_04914</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43028">
        <property type="protein sequence ID" value="OXR43028"/>
        <property type="gene ID" value="B7C42_04914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01485">
        <property type="entry name" value="RecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004586">
        <property type="entry name" value="RecB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF23">
        <property type="entry name" value="PTHR11070:SF23"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="106"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="468"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="DNA-binding and helicase activity, interacts with RecC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Nuclease activity, interacts with RecD and RecA" evidence="8">
        <location>
            <begin position="894"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="8">
        <location>
            <position position="1109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="127"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="969"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1095"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR43028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1212" mass="130165" checksum="A0FCA81B51E2CBF2" modified="2017-10-25" version="1">MTEELFPVTDLRAPEAATHTTTARRRRTRDADASADAAELFAIDEVNTGKGTDLSDTATEPSDAGADSGAEEQRSGGSNVARRVAESDGAGPTSADVRASDGRGGASSFGQFDLCGDLPTGTTVLEASAGTGKTYAIVGLAVRFVAEGLVDISQLLLVTFSRAATQELRERTRERFVTVAAALDDPEAARAGTDELIAHLAAADSAEVARRRRRLVAALSDFDAGTISTTHGFCQRMLDELGIAGEHDPRVRLVEGIEELVSTVAEDLYLARYARGGAPMPVRQAVSLAAAAVADRRARLVPGEELGDHPAAEAAAFAAAVRAEVDRRKRLSGIRDFDDQLVLLHDVLADPVHGERACRRIRDRFRVTLVDEFQDTDPLQWDILRRVFHDHTTLVLVGDPKQAIYAFRGAEVLSYLDAVAHAGTRRELDTNRRSDAGLLAALHHMLGGAALGHAQITVPQVTPVRPHSRLTGPDGAVIPLRLRCFPRQGAGALNGSGFPVVGRQRDRVATDLAADIVRTLESGARFGDRPLGPGDIAVLVRTRAQIDLVRAELDRAGVASVLAGGASVFATRSATDWLWVLRALEQPHRGDRVRLAATTPLLGLSAADIDAGGADLVGRLSTQLRDAARLFARSGFAAVFDRLSAQAQPAPRLLAQSGGERRLTDLRHIAQLLDEVAARESLGLTALTRWLADRVRDPASGAVAGRSRRLDRDAAAVQIATVHASKGLEFPVVYLPFAWDGAKNPNPSTLLFHDGDERVLDVGGPEAPGYAEHRRRCEAEEAGEELRLLYVAVTRAQCQVVAWWAPAYGTAAAPLHRMILGRDPGSAEVPARSEVPADPIVLQQLREWAAAAGPGLIEIEPVRAAVEAQLRTERGHTGDKALEAARFTRSVDHDWRRTSYSALTASAHETGHGATDFVTPDTVEGGTDEPLSPAPELGPGLGAGDEFAGAAPSLMNELPYGAEFGTLVHGVLELVDTDAPDLAAEVRLRCEQAVEQLMADIDPGELARALVAVLRTPCDPVAPAVIRSRDRLNELEFELPLAGGDDPVAERVTVRRIGALLRKHLRSDDPFAGYADALDLLDDVPLRGYLTGSIDAVLRIDGPRFLVVDYKTNRLGTGELTVAHYRRDRMAEEMTRSHYPLQALLYSAALHRYLRWRLPGYDPARHLGGVRYLFVRGMIGPATPPGHGVFDWNPPAELIVALSDLLAGQEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2U0</accession>
    <name>A0A231H2U0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase FadD13</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43171">
        <property type="protein sequence ID" value="OXR43171"/>
        <property type="gene ID" value="B7C42_04593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="427"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="514" mass="54890" checksum="C81FCA3F2ECB8804" modified="2017-10-25" version="1">MPSELTLGDIIGDNAVRFPDVPAYIADGEIRTHSQLLRRATELAAALGECGVRRQDRVAVLSRNGIRFGEVLAMGQLSGIVVATVNYRLAVPEMGSILRDAAPRVLFFESEYLAAVAELRPGLTGVDLYVCLDAPAPGAVEYRELLAAGADRELPFSAVAADTACLIYTTGTTGRPKGCILGQRELRRMGAVLNGEMRSGSSDRAMLVMPMLHIGAIAIALGVHARGGTAVLHRQFEPAAMLATAAADGITILHLAPTMLQTLVDVAGPDSPALAGIRTVVYSAAPVTSTILRSAMAAMPNAGFLNLYGQTEVITSGLPRELHRTATEDDRRRLTSVGYPFPDTEVRIVDGDGRECPPGQPGEIVVRSAVMFRGYWNNDSATAETIRDGWCHTGDVGMFDTEGLLYLVDRKKDVIISGGENVYSVQVEEVVASHPAVAECAVIGIPDERWGESVCAVVVPVEGATVDADDLRDHVAARIARYKAPRRTIVVDELPKLPTGKLDKKVLRARYGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2U8</accession>
    <name>A0A231H2U8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="7">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mmgC_15</name>
        <name evidence="7" type="ORF">B7C42_04586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43164">
        <property type="protein sequence ID" value="OXR43164"/>
        <property type="gene ID" value="B7C42_04586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="141"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="245"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="399" mass="43886" checksum="62A6EF556EA6BBFD" modified="2017-10-25" version="1">MTESAGMEVSYLEARDDWARDPSAYRRALRQFIATEPGLDRWRGGDYPTTEDRMRDNAALSKLLSEGGWNRYGWPVSAGGLGGDERHRAVMYDELSAAGLAVPEQNKLLETLGPAVLRFAPDLAVQFMPSYLAGEEWWGQGFSEPEAGSDLAGLRCRARRAGETYVLSGQKIWTSHGATARRLICLVRTGTLESRHRGLSMIMVDTDTPGVTIRPIALASGHNELAEVFFDDAVVPASRLLGQEGEGWAVAMYLLQFERAMYAWLSATVASRRLRELRAALIGRRLPDGAIRRFGECYSDIATLKARSADTVRRLAAGRTVGPEASIDKILLATVETGLHDLARDVLPGEFLFGDDPAAQQWRAEWWYSRASTIMGGSAEVQRGIIADRVLGLPKERGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H302</accession>
    <name>A0A231H302_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mmgC_17</name>
        <name evidence="5" type="ORF">B7C42_04651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909030.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43229">
        <property type="protein sequence ID" value="OXR43229"/>
        <property type="gene ID" value="B7C42_04651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="208"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="36532" checksum="25915EB59683B898" modified="2017-10-25" version="1">MNLLPAAEQLELVAAATDFLQTRMPIEEIRRRADADSAVDTSVWTEGAELGFLSLGLAEEYGGAGQSFDDEALLFVELGRHLATGPFLASTLGARIAAFSGDEQLCRRIASGQARVGTAQLRGDGSVTSGGFKGTFDLIDTAGCSHLLLVTRHGSALVAAEQFGETTVLDCVDPGTRLATATVTAGEVTHWLPERADSTWLRAVVLSSAFLAGLADGAAALATEHAKTRIQFGRPIGVNQAIKHMCSDMAVRTEAAFTQVCFAAVCLASHRHDAPAQALAARTVAANAAIDNGANGIHVHGGMGYTYEHNAHLYLERAHVYRHLFAEPSEVLAELLAQDLAQDGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H385</accession>
    <name>A0A231H385_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43343">
        <property type="protein sequence ID" value="OXR43343"/>
        <property type="gene ID" value="B7C42_04766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="25832" checksum="AA5C1B7C19E5D20A" modified="2017-10-25" version="1">MQINDSVAVVTGGASGLGLATTKALLADGAHVVIIDLPSSNGEAVAKELGERVRFVAADVTDENAVSQALDVAESLGPLRVAVNCAGIGNAAKTVSKKGPFPLDGFTKVVTVNLIGTFNVIRLAAERIAKSEPVDGERGVIVNTASVAAFEGQIGQAAYSASKGGVVGMTLPIARDLASLLIRVNTIAPGLFKTPLLGTLPDEAQQSLGAQVPHPARLGDPSEYGALAAHIVSNPMLNGETIRLDGAIRMAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3X9</accession>
    <name>A0A231H3X9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Transaldolase</fullName>
            <ecNumber evidence="6 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">tal</name>
        <name evidence="9" type="ORF">B7C42_04491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6 8"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778904.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43623">
        <property type="protein sequence ID" value="OXR43623"/>
        <property type="gene ID" value="B7C42_04491"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="40400" checksum="DF3AF48E3E3C2BF5" modified="2017-10-25" version="1">MAQNENLAALSRAGVSVWLDDLSRNRIRSGNLAELVATRSIVGVTTNPTIFQVALSEGHAYDDQVKELAAQGADADAAIRTITTDDVRSACDVLAEVFESTGGVDGRISIEVDPRLAFDTDKTVAQAVELWKIVDRPNLFIKIPATEEGLPAITRVIAEGISVNVTLIFSVQRYLSVMGAYLDGLRKARIAGHDLARIHSVASFFVSRVDTEIDKRLEQIGSDEALALRGKAGIANARLAYAAYQDVFDGGNHTSTYSHLASSGGNRQRPLWASTGVKNPDYPDTMYITELVAPNTVNTLPEKTLEAFADHGELRGDTVSGTAADAQGVFDALTGVGIDLDDVFAVLEREGVEKFEKSWDELLTATTAELKSTGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4A4</accession>
    <name>A0A231H4A4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B7C42_03964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043292.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43729">
        <property type="protein sequence ID" value="OXR43729"/>
        <property type="gene ID" value="B7C42_03964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR43729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="20879" checksum="CB5AED3BD0520778" modified="2017-10-25" version="1">MITARPRPAWLLLLGTLLGWLAAVTLTIEDFKLLKDPSYRPSCSINPILSCGSVMATHQASVFGFPNPIIGVTGFSVAVTIAVLAVAGVALPRWFWGGLWIGLIAGMGFVFWLIFQSLYRIGALCPYCMVVWTFTPICLAVVTDQLWGGARGIMGIIAQWRWTIVVVYYAIVLLLVFLRFQDYWLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4C2</accession>
    <name>A0A231H4C2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43749">
        <property type="protein sequence ID" value="OXR43749"/>
        <property type="gene ID" value="B7C42_03984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="25884" checksum="C9C2158E36A6576A" modified="2017-10-25" version="1">MTTPDTAVPAPAPAGEPRRRNGRRIALIVGLVVLLALVGTAAGAETYLRHKNQQCMASQVEKELGSKVDVGFGPKPLLLTAVDHKVQYITVDSDDAKFGPAVDMKVHAKLNDITLLDGGRGGAKVGSSSADATWSNEGIAQTLTGLVSGVESDPAGGTLDVKVLGGIADLKVQPHIVNGKIEVSTQSASLLGLGLPTDLVDSIVQSMTQSLQNYPLGMQPTSVKVTDNGISVSLRGGPTTLQGGGDTQIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4W3</accession>
    <name>A0A231H4W3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781149.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43832">
        <property type="protein sequence ID" value="OXR43832"/>
        <property type="gene ID" value="B7C42_04067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="92" mass="9520" checksum="4949326EB6BCB3B2" modified="2017-10-25" version="1">MQTLIDDLTELWRVTAAALIFGAGLPAIFALGVRLHSIAGAAPQPDSTRRRAAAACAGLCYSVVTLTVIAGVLFVARGFLAARLGIHLFGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H573</accession>
    <name>A0A231H573_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514753.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44093">
        <property type="protein sequence ID" value="OXR44093"/>
        <property type="gene ID" value="B7C42_03649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="9624" checksum="C10AB5A965AB2910" modified="2017-10-25" version="1">MITAIVLIHAEAARIPETAQALADLDGVAEVYSCAGDVDLIAVVRVRDHERIAEVVTGRVNKTAGVLRTTTHIAFKSYSSADVEAGFSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H583</accession>
    <name>A0A231H583_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glkA_1</name>
        <name evidence="2" type="ORF">B7C42_03659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44103">
        <property type="protein sequence ID" value="OXR44103"/>
        <property type="gene ID" value="B7C42_03659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="36445" checksum="EF9CCCBF470196DE" modified="2017-10-25" version="1">MTTRLGREAPLTVGIDVGGTNIRASVVDGDGEVLDTVQAPTPHSAHALEDGLDRAVRELCARHDIGAVGLAVAGFVDESRSSVRFAPHLPWEDTAVAGRLGHRLGLPVILEHDANAAMWAEYRFGAAAGAHNGVLVAIGTGIGAALLVEGRLYRGSYGVAPELGHLQVVPHGRICPCGKRGCWERYCSGTALVDTAIEMLATDPMPSTILAREVVGDPGSLTGRRVAGAAHDGDPVALHVMADFARWLGLGLAFVSDIFDPDLIVIAGGVSSSAPLFLDDAREHYAAAITGGRHRPLARIRTTQLGEAAGMIGAAELARTALEAGAAEGHAQATGRAESAAVPRARSTAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5E7</accession>
    <name>A0A231H5E7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase LiaS</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">liaS_4</name>
        <name evidence="3" type="ORF">B7C42_04195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43956">
        <property type="protein sequence ID" value="OXR43956"/>
        <property type="gene ID" value="B7C42_04195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="40646" checksum="94E831AA5EA585F7" modified="2017-10-25" version="1">MLMTALVVVVMVRAAVPGDDVARPTVAVIVLAALFLVVYFAGGLLRGRPVAARVWLGGLTVLWLALIVLVPEAVYLVFGLFFLYLHLLPRLWGLAAVVAATVVSVVGWGLHEGWTVPGIAGPVLGAIVAIAIGLGYRALFREAADRQQLIDELLSTRATLAERERTAGRLAERERLAQEIHDTVAQGLSSIQMLLHAAERDAPDHPALQQIRLARETAADNLVETRQLIGDLTPAVLEGQSLSDALERIARRAEGPGLSARTVVEGTPMRLPMPVEAALVRVAQGAVSNVVRHARADRMRITLTYGDDAVHLDVVDDGVGIDPAVFGGGTFGLNAMRSRVEQQGGVMDVESEPGHTAVTVSFPLHDSETAGAELISREDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5N2</accession>
    <name>A0A231H5N2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ftsW</name>
        <name evidence="12" type="ORF">B7C42_03688</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44130">
        <property type="protein sequence ID" value="OXR44130"/>
        <property type="gene ID" value="B7C42_03688"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR44130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="507" mass="54027" checksum="896115D024514558" modified="2017-10-25" version="1">MTKPARKPVGTWFGAWLARPLADFHLVVTIATLLTVLGLVMVLSASSVEAYADGGSAYSLFMQQAFFAGLGAALFYLALRIPMRVLRQLSFPLYAASVLLLVLVLIPGIGSQVQGSRRWFDLGFVSVQPSEIVKVTLIVWGAHLLATRRSDQTGYKDILVPLVPAGLLTCLLIVLEPNLSTTIAVGLVLVALLWFGGLPVRLFVTIAVSGAVAAGILALSAGYRSDRMRAFFNPGDDPQGIGYQARQALFSLADGGIWGRGLGQSRAKWSYLPNAHNDFIFAIIGEELGFLGCALVLGLFALFVFVGLRIASRSADPFLRLLTAAATTWITGQALINIGYVVGLLPVTGLQLPLVSAGGSSLAITLMMFGLIASAARHEPEAIAALKGGQDGRFSRLLRLPIPETYAPARAGRARAVSGPRRRELPPARKRSGKSGQSRGGGKSRGAAAARGGSAAIPRRSIDSDSARRRSADAGRREARGASSWRTTRAWEPSYPMTHARERGNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Y1</accession>
    <name>A0A231H5Y1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aroG_2</name>
        <name evidence="4" type="ORF">B7C42_03662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44106">
        <property type="protein sequence ID" value="OXR44106"/>
        <property type="gene ID" value="B7C42_03662"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="516" mass="56827" checksum="79E154D094F50344" modified="2017-10-25" version="1">MPFPIRRTPALAVISRPNRPTRPRARGYGPARAGVFIAPYPPGYPEIAEGPYSDLVNWTVDVPIDRLPELPPLPAELRRRLDAALARPALQQPSWDPEQAATMRTVLESVPPLCVPAEVEELRLHLAEVARGEAFLMQGGDCAETFADNTEPHIRGNIRTLLQMAVVLTYGASLPVVKVARIAGQYAKPRSADVDALGLKSYRGDMVNALVADAAQREHDPSRLVRAYANASAAMNLVRALTGAGMADLHKVHDWNRDFVAQSPAGARYEQMASEIDRGLAFMNACRVQDPSLQSAKIYCSHEALVLDYERAMLRLSHNAAGDPVLYDLSAHFLWIGERTRQLDGAHIAFAELLANPIGIKIGPSTTPDQAVEYVERLDPTNEPGRLTLVARMSNTKVRDVLPPIIEKVQATGHQVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGFFEVHHALGTHPGGLHIELTGENVTECLGGAQDISDLDLEDRYETACDPRLNTQQSLELAFLVAEMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Z9</accession>
    <name>A0A231H5Z9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_03885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44324">
        <property type="protein sequence ID" value="OXR44324"/>
        <property type="gene ID" value="B7C42_03885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17140" checksum="9A88EB274BC7778E" modified="2017-10-25" version="1">MSVGAEGAAAARVAGEQDNPPPGLLLRLIRRQEIAFAAVGAANTLLGMALTVMWLKLLPGGWPPAVAVALAYSISIVFAFFAHRTLVFRVRGHLVADFVRFVAVNSGGLILNMAGVQLAVGVFDLPETPATVVVMGVVAVLSFFGHRHISFRRAVRPADRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D3</accession>
    <name>A0A231H6D3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative L-lactate dehydrogenase operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lldR_1</name>
        <name evidence="5" type="ORF">B7C42_03911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782874.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44350">
        <property type="protein sequence ID" value="OXR44350"/>
        <property type="gene ID" value="B7C42_03911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="24099" checksum="249AE348111EC243" modified="2017-10-25" version="1">MATVQRQPLAAQAAQLLLDRIRAGEWQLGHKLPGETTLAAQLNVGRSTLREAIRELSGQGVLESRQGAGVFVTALDVAEDWDEVLRRADIAAVIEARIAIEAEAAALAAQRRTPADLRIMRKALSVRAGSDDSVEHLVDADTAFHRTVIAAAHNEVLLQLFDAFVPRVHRAMTEMLRMRPMADPAADHHAHEVLFAAIRDRSADTAATASRVHLSALKSAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D5</accession>
    <name>A0A231H6D5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RCS-specific HTH-type transcriptional activator RclR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rclR_3</name>
        <name evidence="6" type="ORF">B7C42_03913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782876.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44352">
        <property type="protein sequence ID" value="OXR44352"/>
        <property type="gene ID" value="B7C42_03913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="209"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="322" mass="34502" checksum="A3447D11676B8DC8" modified="2017-10-25" version="1">MDALADLLDGPRARGAFVMRSLLDPPWSLRIQDRAPLTVVVVTRGYAYLVPDGDDPIRLDEGAVAILRGPDPYTVADAPSTPPQAIVHPGQTTTTPNGELLCETWDLGVRSWGTNAAGTTALLTGTYEVAGTVSDRLLRALPPRAVLDGHEVDERLLGLLVDESGRDVPGQASVLDRLLDLLTIAALRTWFARAEAPQWYSAYADPVVGQALRLLEHNPAHDWTVAELAATVGASRAALARRFTELVGDPPIAYLTEWRLARAADLLRGTDATIESIARQVGYGTAFSLSAAFKRRYGVSPGMHRRTEPLTAEAEPDAGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6G4</accession>
    <name>A0A231H6G4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase DesK</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">desK_2</name>
        <name evidence="5" type="ORF">B7C42_03218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44429">
        <property type="protein sequence ID" value="OXR44429"/>
        <property type="gene ID" value="B7C42_03218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="199"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="419" mass="44054" checksum="492C0DEE21AB2B96" modified="2017-10-25" version="1">MRPGGVTVRTVQSSTRPGARDVMLSVVVAAVQLGAGHAANAHQSGVRPLDALGYALLVAGPLLLALRAMYPRAVFVGVLAVTVAYLLVGYGYGPVFVSLVIAFLTAASRGSRWYTYPLVPLGYLLMVWPVPALRGHGPGSWPAAGILAWLVVLIAIAEGIRQRRSALIARRQRAEAARRNREAERARELAEREQRAAQERLAIARELHDVLAHSLSLINVQSSVALELLDRKPEQAATALSAIKEVSRDAIGEVHSLLRSIRAGAETVAAPTGPAVGIGDLESLLAPTRAAGTAVHTRISGTPRRLPVVVDVAAARIVQESLTNVLRHAPGAETTVVVDYSPSELCITVDNERPPNSPQSSTTGGGNGIPGMVERAHALGGEVSATPRADGGFRVDARLPIPLPAAGEPAPPVEPPQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6G8</accession>
    <name>A0A231H6G8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">disA</name>
        <name evidence="13" type="ORF">B7C42_03234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44445">
        <property type="protein sequence ID" value="OXR44445"/>
        <property type="gene ID" value="B7C42_03234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="12">
        <location>
            <begin position="48"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR44445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="44006" checksum="DD303502BC3B184B" modified="2017-10-25" version="1">MIPGRWVTHLLGRPAPRRRFVTPAEVPAAADGAAPVDGVPVEAVQADDPGLSTTIARLVPGTELRDGIDRILRARTGGLIVLGYDEELERICDGGFELDVEFSPTRLRELSKMDGAVVLSTDGARIRRANVHLVPDPGLPTTESGTRHKAAERTAAQTGYPVVSVSRSTGIVTVYLNGHRHPIQTSETILSRANQAMATLERYRSRLDETTRQLSLVELNDCATVRDVLAVVHCLELVRRVAREISSDVAELGVDGRQLALQLAELVGNTEALRRLLVRDYIRTEPVDDAMVDRTLAALDGLLEVDLLELTNLAPPLGFPATFEALDTAVGPRGYRVLAEIPRVPLRRAEPVIAAFGSLSGLVSASVSEIEGVDGIDAHLARQIREGLSRLSESGAVRSTESGTVRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6P9</accession>
    <name>A0A231H6P9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497777.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44594">
        <property type="protein sequence ID" value="OXR44594"/>
        <property type="gene ID" value="B7C42_03384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7969" checksum="BF5F4355A943EFBF" modified="2017-10-25" version="1">MGRGRAKAKQTKVARELKYSSPSTDFASLQRELSGHTPRRSGVLSEEHDSDESLKRWEEDEDYDDWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6R2</accession>
    <name>A0A231H6R2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44561">
        <property type="protein sequence ID" value="OXR44561"/>
        <property type="gene ID" value="B7C42_03351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15752" checksum="DBB7D2737E8427C7" modified="2017-10-25" version="1">MKPMPSVFSAIIAGQLPGRFVWEDEEFVAFLTIAPVTQGHTLVVPRKEIDQWQDLDPATFARINEVAQKIGQAVRKAWDAPRAGLLIAGLEVPHLHVHVFPAFELGDFNISGADTDPSPESLDEAQDKIKQALRDLGYGANVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7J4</accession>
    <name>A0A231H7J4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041928.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44727">
        <property type="protein sequence ID" value="OXR44727"/>
        <property type="gene ID" value="B7C42_03521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="25978" checksum="5DD5E096CDD93F62" modified="2017-10-25" version="1">MTTPITTLTGHRSGIEWLNLFESEQPDPRAARLAQWSREYLTAPHEELGRPGAVCPFISQAIAKCLLWATFVDGDVGAPALDVVVDDMYDRFVHLTTISDWKRPHALITVLTELSDHTVIDEVHAARKTQFVEQGFMLGQFYPGCSHPGLWNHDFHPLDTPWPMIVARNMMTTDLPFLIARPDWLRAYFKTFAPALPTALRCRLAEDLCDHGDAIADITANHALIGSEYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7P1</accession>
    <name>A0A231H7P1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44736">
        <property type="protein sequence ID" value="OXR44736"/>
        <property type="gene ID" value="B7C42_03531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="488" mass="53968" checksum="10F3C28ADFAF8D48" modified="2017-10-25" version="1">MTATPSIVIIGAGFAGLGMALELQRAGIDNFTIVEKAGDLGGVWRENTYPGAACDVPSPLYSWSFEPKSDWPRRFSQQRDIHAYMRAVAEKYDLPRKIRFGIEVTDAEFDAARGVWQVRTAGGETLTADVLIPAVGQLSRPAMPNIPGIDTFTGPAFHSAEWDHDVDLTGKRVACIGTGASAIQYIPAIQPTVGHLTLFQRSAAWVLPKFDTEYTGLHHALFKYFPPSRWAERFAIWTFFEVMALALTDVPWIKHPVIAIADRHRANAVPDEELRAKLTPDYAAGCKRGLFSNEYFPALAQPNVSVETTAIEAVTANGIRTADGVEHPVDVIIYGTGFKGTEFLAPMHIYGLGGRKLSDEWAPEGARAFLGMSVPGFPNLFMMYGPNTNVGSGSIIYMLESQARYIRQLVEYLSAKPGHFLAARPAAEQAWDDWLRKRLADTPWNFCSSWYRNASGRITNNWPGATLLFRWKTRRFDPADYAEGVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7W0</accession>
    <name>A0A231H7W0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor CarH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carH_1</name>
        <name evidence="2" type="ORF">B7C42_02835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44880">
        <property type="protein sequence ID" value="OXR44880"/>
        <property type="gene ID" value="B7C42_02835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="35206" checksum="1A5050D14C6A22AE" modified="2017-10-25" version="1">MRNRCILEVPARIAPTARVPLHRDVVAPMPAKGRMIVMSDVSPPDNDATGFSVRTVAERIGIPTATLRSWNQRYGIGPSQHRRGRHRLYSEADIARLERMVVLVRGGSSPARAAESVRGPLPVAGDHASLLEAAFASDPTTLQSLLLAHIRAFGVVDTWDRLCRPAFAEIVQRQGAGVGCIDVEHLLSWCITAALHRAVPPPADAPATPVLLACTSGEAHSLPLEVLRAALAERDVPATMLGPNVPTPALGDALDRSAPDSVAVLWSQQESTALLSAVRTCADRGARVLLAGPGWQDIPAPHTAEIVDDLQSALTDLTRAHPAEVPSRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7X6</accession>
    <name>A0A231H7X6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44945">
        <property type="protein sequence ID" value="OXR44945"/>
        <property type="gene ID" value="B7C42_02902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012014209" evidence="1">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="16102" checksum="5A41BF117983D281" modified="2017-10-25" version="1">MNGDTIRRGSRPLFGAAAAAALLMLAGCGSSDSGNARPADSVAPKATTTGTVPEVIDCSFSKPAVRPENMILACADLGAQVEQIVWQSWGPDQAQGDGVERENTCDPNCAAGKYITKKVHLTLTDVARPGNVFTKVTTVDADGHTYTWPRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H883</accession>
    <name>A0A231H883_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nrdE2</name>
        <name evidence="13" type="ORF">B7C42_03005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5 10"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45048">
        <property type="protein sequence ID" value="OXR45048"/>
        <property type="gene ID" value="B7C42_03005"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026459">
        <property type="entry name" value="RNR_1b_NrdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013554">
        <property type="entry name" value="RNR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08343">
        <property type="entry name" value="RNR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04170">
        <property type="entry name" value="RNR_1b_NrdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR45048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="727" mass="82338" checksum="8352B60E023439E3" modified="2017-10-25" version="1">MATTTAPAGKTARLERPVSTETSTEGLDYHALNAMLNLYGPNGEIQFDKDVAAARQYFLQHVNQNTVFFHNLDEKLDYLVEENYYEPEVLDQYSRAFVKKLFQQAYAKKFRFPTFLGAFKYYTSYTLKTFDGKRYLERFEDRVCMVALTLAAGDEVLAQQLVEEIIDGRFQPATPTFLNSGKKQRGEPVSCFLLRIEDNMESIGRSINSALQLSKRGGGVALLLSNIREHGAPIKKIENQSSGVIPIMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKKNEDMYLFSPYDVERIYGVPFADIDVTEKYYEMVDDKRIRKSKINAREFFQTIAELQFESGYPYIMFEDTVNRANPIKGKITHSNLCSEILQVSTPSVFNDDLSYAKVGKDISCNLGSLNIAKAMDSPDFGQTIEVAIRALTAVSDQTHIYSVPSIEQGNNESHAIGLGQMNLHGYLARERVHYGSEEGVDFTNIYFYTVAYHAVRASNKLAIERGTAFGGFPESKYASGEYFDKYTEQAWEPKTDRVREIFAEAGVHIPTQEDWRELKASVMEHGIYNQNLQAVPPTGSISYINHSTSSIHPVASKIEIRKEGKIGRVYYPAPYLTNDNLDYFADAYDIGYEKIIDTYAAATQHVDQGLSLTLFFKDSATTRDVNKAQIYAWRKGIKTLYYIRIRQMALQGTEIENCVSCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8C2</accession>
    <name>A0A231H8C2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-(R)-hydroxypropyl-CoM dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.268</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xecD_3</name>
        <name evidence="2" type="ORF">B7C42_03042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.268" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45085">
        <property type="protein sequence ID" value="OXR45085"/>
        <property type="gene ID" value="B7C42_03042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050574">
        <property type="term" value="F:2-(R)-hydroxypropyl-CoM dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="31249" checksum="2DE64C382CA69524" modified="2017-10-25" version="1">MVRTLLAPVLGGGERLDVRDKVVVITGGAAGIGYELARLLYDRGAYVALFDIDAEAVRASAAALGIRAVAITVDVADREGVRLAVGQVRENFGRIDVVVANAGVVPRPATVRLLDPEEFDRVLAINLTGAFNTVQPALDDVIAAHGHVVVVSSCAAFAPGMGGSPYMVSKAGVEQLGRALRVELGGTGASAGIAYFGVVETAMTHDTLDEDELGAEFGALLPWPLNQRITARRAAEVIAGAIERRSARTVAPAGWEPYALLRGAVNVALDHKLSVDERVRSLTQRLEERILADRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8P2</accession>
    <name>A0A231H8P2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">nnr</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="17" type="ORF">B7C42_02518</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 15">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 15">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="14"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45393">
        <property type="protein sequence ID" value="OXR45393"/>
        <property type="gene ID" value="B7C42_02518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 15" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="16">
        <location>
            <begin position="14"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="392"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR45393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="489" mass="49175" checksum="C892A47246B8708C" modified="2017-10-25" version="1">MAPALRGYFTVDEVRAAEAELFERVAAGVPMRRAAYGLANVVAAELRERTGGIAGRAVTLLVGSGDNGGDALWAGATLRRRGVAVTAVLLSPERAHAEGLAALRRAGGRIREADAGSAAELLGAPDLVVDGIIGISGRGALRPRAAELVAAAEVPIVAADLPSGVDPNTGAVDGPAVRAAVTVTFGACKPVHALAAPWCGRIELIDIGLRLPAPTLAALEPVSIGRDWPVPGPHDDKYTQGVTGIHAGSDTYPGAAVLCTGAAVAATSGMVRYAGTAAAQVLAQFPEVIAAESISDTGRVQSWVFGPGAGTDDAARERLAEILAADLPVVVDADGLTLLAAAPELVTGRAAPTVLTPHAGEFARLTGRELGADRVAAVRELAEKWQVTVLLKGRATLVATPGEPTLVNEAGGSWAATAGAGDVLSGVIGALLAAGREPAWAAAAAARVHALAANLAAHANGDAGAPISATPLLHHLRAAVRTLRSLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8R4</accession>
    <name>A0A231H8R4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">groS_1</name>
        <name evidence="4" type="ORF">B7C42_02374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513633.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45249">
        <property type="protein sequence ID" value="OXR45249"/>
        <property type="gene ID" value="B7C42_02374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11700" checksum="F8638BF35F287298" modified="2017-10-25" version="1">MSDAKLEIQMLHDRIMVRVSQEEGERRSSGGILIPATAQVAKRLTWGEVSGVGSHVRSVGVGDRVLFSAEDQFEVEVQGQAYLVLRERDLHAVASERPEHGTGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H933</accession>
    <name>A0A231H933_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45359">
        <property type="protein sequence ID" value="OXR45359"/>
        <property type="gene ID" value="B7C42_02484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="58" mass="6267" checksum="7418CAC2D028E41B" modified="2017-10-25" version="1">MGLWTAWRRRSAARDEKAGADARAKAIAAGASEREAAAAAEQAVRRARRRRRALYAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9F5</accession>
    <name>A0A231H9F5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45461">
        <property type="protein sequence ID" value="OXR45461"/>
        <property type="gene ID" value="B7C42_02586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="21657" checksum="13DCB63343795066" modified="2017-10-25" version="1">MSIRIRQARTADLGNICRLRLQRTAWLAARGSDQWTRQGRGLPIERFARAVGRSVAAGETWVAEVGGEFAGTVTVNDRADPGLWSPREIADAVIVHYMIVDLRFAGYGVGRALLAHAASLALVRQRNWVRLDAWTRNSELHRYYRSAGFRLARIANPAVSGPSAALFERRADSWDLPEPIVRRHLHADRGDPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9I2</accession>
    <name>A0A231H9I2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513409.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45490">
        <property type="protein sequence ID" value="OXR45490"/>
        <property type="gene ID" value="B7C42_02615"/>
    </dbReference>
    <dbReference type="GeneID" id="66718969"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="6854" checksum="8AA53078BFE125B1" modified="2017-10-25" version="1">MTERSIAMNPGMHEVLDYFGKCPECGYPARASADFAGAPTVVASCDRPCGWTGVVPLTTMTGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9S3</accession>
    <name>A0A231H9S3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Caffeyl-CoA reductase-Etf complex subunit CarC</fullName>
            <ecNumber evidence="6">1.3.1.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carC_1</name>
        <name evidence="6" type="ORF">B7C42_01891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.108" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783980.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45599">
        <property type="protein sequence ID" value="OXR45599"/>
        <property type="gene ID" value="B7C42_01891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="231"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="40787" checksum="17EE801153C6FB1F" modified="2017-10-25" version="1">MADNTEFAFTREQQELRAAVRGFCADHSDEATVRRLMESTPAFDQKAWLRLGSELGVLGLGVPEELDGSGGGIVDAAIAIEELGSALFCGPVFGTLMLSIPALAAAPDTPVRTEILGPLVAGVRTAAFAVPDRAGRFAADAVTLRANGSGDIWTVSGTVERVVDAGAADDLLVAANVPDGVALFVVDATGFGVERIALSTMDSTRPQATVHLAAAAARLLAGPDEAARICERALQVGAVLLAAEQVGGAQRMLDLSVSYAGERLQFGRAIGSFQAVKHRLADMLVDQEHARSAAYHGAWALQDGTDDPVVAASIAQAVCSAAYTRIAADAVQVHGGIGFTWEHRAHLYFKRAFTDAALLGSAEDHRDRIAELVLDTRNGDYEVAVATGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9V4</accession>
    <name>A0A231H9V4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45629">
        <property type="protein sequence ID" value="OXR45629"/>
        <property type="gene ID" value="B7C42_01921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="21566" checksum="34FE4AACC8C77370" modified="2017-10-25" version="1">MANSVGALYDRPVTLSPADLIGYVDSGLDADLSRWFADAEPVVVPEQTRSATPFLARLAPADAAALAALDTQVRSGVMPQFLDIFDWSYGFDFAGNECGILDADYTTELTDADVFSVGADGGGNLFCVLTNGQVALWFHEEEVLEGGTRFDNLDVFVWSFLRYRAVRAGRLELEAVAADFRALGQDGALEPQLGLLSLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Y8</accession>
    <name>A0A231H9Y8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45678">
        <property type="protein sequence ID" value="OXR45678"/>
        <property type="gene ID" value="B7C42_01970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9483" checksum="0CA74B6D3A515CB6" modified="2017-10-25" version="1">MADESHISHRNAVDKVMAAHSFAVELPLLGRVPVPRPEQLAYYGALGALAAAEIIEWPVALVLAGGHWLAENQHNRVAHEIGEALEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA74</accession>
    <name>A0A231HA74_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Group 1 truncated hemoglobin GlbN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glbN_1</name>
        <name evidence="4" type="ORF">B7C42_01938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45646">
        <property type="protein sequence ID" value="OXR45646"/>
        <property type="gene ID" value="B7C42_01938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABM" evidence="3">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="28321" checksum="E04F68EDF336364E" modified="2017-10-25" version="1">MTIEYVRYRISEPDAAEFEAAYGRAARSLAAAPQCVDYELSRCVDEPECYVLRISWTSAEDHIQGFRGGAHFAAFFAEIEPYVQRIEEMRHYERTAVRGSGSSVPSMYDWLGGIEALERLTKVFYTHVLADDLIGPLFAGMDPGHPHYVAMWLAEVFGGPSRYTGERGGYDHMLAHHLGKAISEPQRRRWVSLLLDAAGEAGLPADPEFRAAFVGYIEWGTRIALGNSQPDADPPRHLPVPHWGWGVAPPYTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAW9</accession>
    <name>A0A231HAW9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent Clp protease ATP-binding subunit ClpC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpC1_1</name>
        <name evidence="5" type="ORF">B7C42_00983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46020">
        <property type="protein sequence ID" value="OXR46020"/>
        <property type="gene ID" value="B7C42_00983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="4">
        <location>
            <begin position="91"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="29286" checksum="8E9A2F7C3E95891F" modified="2017-10-25" version="1">MTERIRLDDLIEGIKLARPDDVLEQLSDAVVVAGHMSEVADHLIGHFVDQARRSGASWTDIGQSMGVSKQAAQKRFVPKPGDAAMDPNAGFARFTPRARNVVMASMEEARRAGNPEIQPEHLVLGLLSEPGALAAHAIVAKGVSLDAVRRVATAALPVAVDEVPALIPYTATARKTLELTFREALRLGHNYIGTEHLLLALLEQEDGRGVLSGLGLTKSDIERDLVAQLAQFMPPNPVDAPQPPVAPQPPTPPTPPTPPTPPSPPAPPEPLAAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAY0</accession>
    <name>A0A231HAY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45982">
        <property type="protein sequence ID" value="OXR45982"/>
        <property type="gene ID" value="B7C42_02275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167063" evidence="2">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="12756" checksum="60B176211C3D34C4" modified="2017-10-25" version="1">MPLRKSLLGSRTGSVRSKTVTTVRASLTPEALTTGGLLLTAAGLALLGPLLAAMLIRASGAGRTDAAATTPLVLAMLAVIVAVASGFALFVSAWRRAHTSAPGRVHRVSPVRAESVRSELDSGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBH2</accession>
    <name>A0A231HBH2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781481.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46162">
        <property type="protein sequence ID" value="OXR46162"/>
        <property type="gene ID" value="B7C42_01127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011259551" evidence="1">
        <location>
            <begin position="27"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="22461" checksum="67BC3AB141185772" modified="2017-10-25" version="1">MNLRSLTAASALTIGALTAGLTTAHADPAPTPEQTGIRYSVKLVDKTVVTTLQGGTFRLAQDEKSYSVTDSHGATVVSLPTDVRVDDVAVPVKPVVKNDGTVLELTPQKTMTTDHPVAVQPIASPLENQRAMNDFSTQFGIATAVGGFVGTAIGVVVGGITGCILGLPLLGVGCIPAAIAGAGVGGILGTIAVGGPALGIAGLDLINTLQAAPGTSKWAKDSAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBL2</accession>
    <name>A0A231HBL2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na(+)/H(+)-K(+) antiporter GerN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gerN</name>
        <name evidence="7" type="ORF">B7C42_01174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46209">
        <property type="protein sequence ID" value="OXR46209"/>
        <property type="gene ID" value="B7C42_01174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="13"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="425" mass="44142" checksum="B0187A68748DFB52" modified="2017-10-25" version="1">MPAPTITVLLDLVLIMAAAHLLGRLAEKIGQPPVIGEIAAGILAGPTVIGHHLSATLFPEAGRSYLTLLANIGVAVFMFVAGLELDREIFRGARRSIPAVSAAAYAIPFVLGSAVAITVLARHSTGNRLHFALFVGCAMAVTAFPVLARILHDRNLVRTEIGQLSLACAALVDVVAWSVLAVVLALAHPGGVQWRLVLLLPLVGLLWWFVRPLLTRISESGTQQTMIVLGVGGALGLAAITEWIGLHLIFGAFAFGVIFPRERRRTVESGVRILCLLLMPGFFVIAGLAVDLGSVDATSIGELIAVIGVAVVGKVGSVYVAGRLTGMPSRAAAAVAALLNTRGLTELVILNVGLTTGLIGTQLYSLLVIMALVTTASTAPFLRLLGISRGGDLSSRPPHAPDSEDDPDPGAVAAAAQSPDTSGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBV8</accession>
    <name>A0A231HBV8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigJ_2</name>
        <name evidence="8" type="ORF">B7C42_01202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46236">
        <property type="protein sequence ID" value="OXR46236"/>
        <property type="gene ID" value="B7C42_01202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="35116" checksum="F7F8C27329152318" modified="2017-10-25" version="1">MRDRDELARRFEEHRELLRAIAYRMLGSLNEAEDAVQEAWLRLDRATGTAATEHGERGAAEGDAAGKGAVDDAAVDGLAIDNLAAWLTTVVSRICLDQLRSRAARREELVEPATGSFALDSTGAGPRPVVFTEPEAEAVLADSVGRALLVVLRTLSPDERVAFVLHDMFAVPFDDIAPIVGRTAATTKKLASRARHRVRGDTATPTAELARHREVVTAFLSAARAGDLGALLAVLAPDVVRTADPAMLPPGIASVVRGAAAVAEETVLLRSRSRVAGLALVDGRLGLVVAPHGELAAVLLLTVREDRVAAYDVVADPARLEALTIAVPPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCI4</accession>
    <name>A0A231HCI4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Teichoic acids export ATP-binding protein TagH</fullName>
            <ecNumber evidence="6">3.6.3.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tagH</name>
        <name evidence="6" type="ORF">B7C42_01582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.40" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775216.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46611">
        <property type="protein sequence ID" value="OXR46611"/>
        <property type="gene ID" value="B7C42_01582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="29500" checksum="CF2732882CE92841" modified="2017-10-25" version="1">MTGVSIETHQAWVEFPIFDAKSRSLKKAFLGKAGGSIGRNQSDVVVVEALRDITLSLKEGDRVGLVGHNGAGKSTLLRLLSGIYEPTRGSARVRGRVAPVFDLGVGMDPEISGYENIIIRGLFLGQTRKQMLAKVDEIADFTELGEYLNMPLRTYSTGMRVRLAMGVVTSIDPEILLLDEGIGAVDAEFMKKARNRLRDLVARSGILVFCSHSNEFLAQLCDTAMWIDHGTLRMQGDIEDVVRAYEGPEAGDHVKQILRELELERDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCK8</accession>
    <name>A0A231HCK8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46693">
        <property type="protein sequence ID" value="OXR46693"/>
        <property type="gene ID" value="B7C42_01668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012827756" evidence="2">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="120" mass="13008" checksum="0AAD58E7AE469151" modified="2017-10-25" version="1">MNIRATIKAAAAACLLGVALLGTPAHADAAPAHIGWCPFGHVDPHDDNSACRGSDSAEWPLSEHGPDGKPTVSCTRLNEGRGVRTDHGDHGYSYWRCMSYKDQWGNVYFDWSEVLEAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCL9</accession>
    <name>A0A231HCL9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5926 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775097.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46526">
        <property type="protein sequence ID" value="OXR46526"/>
        <property type="gene ID" value="B7C42_01496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045970">
        <property type="entry name" value="DUF5926"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19348">
        <property type="entry name" value="DUF5926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5926" evidence="2">
        <location>
            <begin position="36"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="308" mass="32680" checksum="FD4A43100D174F60" modified="2017-10-25" version="1">MGKSKRNSPKPDSNRAQRLAERRAAQQQAASAVTRPFAGLAAECDLVALREFVPSATATLELAAGVSAERPVTLATVLPGAVAALVRAGDEPTGFVGAQVQVQSDDPAADLAAAILWTQAAEPGESLTAASEAAQDAVPPLSEVIDPKANLDLTVHQNFQWWVPEGVTPDPQVAATIDQADQAIMPSDRLALGAESVGAAWWVDAGEKAHLRWVRPEDEDALMLALARVHAAGGLHLGDGSRFAGSFRTHGLLVPVFDLDRERHPSEWVTPAHEFGARLAEALASDAPLSSEERRSRDGLRSRQVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCT3</accession>
    <name>A0A231HCT3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactofuranosyl transferase GlfT2</fullName>
            <ecNumber evidence="4">2.4.1.288</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glfT2_2</name>
        <name evidence="4" type="ORF">B7C42_01577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.288" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46606">
        <property type="protein sequence ID" value="OXR46606"/>
        <property type="gene ID" value="B7C42_01577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045699">
        <property type="entry name" value="GlfT2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040492">
        <property type="entry name" value="GlfT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19320">
        <property type="entry name" value="GlfT2_domain3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17994">
        <property type="entry name" value="Glft2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glft2_N" evidence="2">
        <location>
            <begin position="62"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="GlfT2_domain3" evidence="3">
        <location>
            <begin position="445"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="631" mass="70523" checksum="4AF9246C293607CC" modified="2017-10-25" version="1">MDQSAGQAVTATENDPRIAEPAPGALRTEHRAPDRLVLARGIFTGPAPKISDELYAVVKGKSHRERLSLRLEKGAHAHTNTYFGRFAASYWQRWTTVTEVEVSMRVAVGDRARIRLAASDIAGHRRIIDSADVDSDGVITLRAPLDQYVDGGALWVEFDAVGGELAIGELTWTAPAPDRVRPVAIAICTFNRAEDCAHTVAALASDPEVLAAIDAVYVVDQGTDLVSDRELFQQTQPRFGDKLRYIRQPNLGGAGGFTRGLYEVSAANEHADVILMDDDILCEPETVLRLNAFANLTVEPTLVGAQMLFLLNPDYLNVGAEEVHLNELRHGQKVPKALRNTSMLKRNQERRVDAGYNAWWTCLIPAEVVARIGLPLPIFFQWDDVEYGVRAREAGFVTVTLPNAAVWHADFYWKDFDDWARYFSMRNSLIVSSMHTDLDAKAVTRKLFREIAEYLVGMQYGLAHTTLQGIEDFLQGPKILRDGGIQALAAARTSRGDYGETKKHPAATAPVRQSDIQLRRAGGEPSRPLLVLVKRAIQQWTGRTQHGVVGVTREDAHWWHLALFDHVVVTDASQSGVRIRQRDKEKARALLLRTVRVLRRLRRELPELSRQYRAAAPELTSRENWERLYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD07</accession>
    <name>A0A231HD07_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">murD_1</name>
        <name evidence="1" type="synonym">murT</name>
        <name evidence="4" type="ORF">B7C42_01789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46811">
        <property type="protein sequence ID" value="OXR46811"/>
        <property type="gene ID" value="B7C42_01789"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="53"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="296"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="43100" checksum="1B6106FDDCA87C4A" modified="2017-10-25" version="1">MRGRLALRAAAAASWASQKAGRGKGSMIGGLIALQIAPDIMTQLGRDRRTVLVTGTNGKSTTTRMTAAALAELGRVVTQADGANMDAGIVAALSVDRAAPLAAIEVDELHLPHVADALNPAAVVLLNLSRDQLDRVGEINMIERKLREGMARHPDTVLIANCDDVLITSIAYDHPNVVWVSAGSGWAVDATSCPRSGEPIVWEGTHWRSTGADFQRPDPQWWVDAEYLCGPDGLKLPLHLALPGRANRGNAAQAVAAAVALGGRAETAAQAAGTVREIAGRYRTVQVGEHSARLLLAKNPAGWQEALSMIDPDATGLVIAVNGQVPDGEDLSWLWDVRFEHFEGTQVVAAGERATDLGVRLTYAGVEHTTVPNPLRAIASCPPGRVEVLANYTAFRDLNRDLDGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDA1</accession>
    <name>A0A231HDA1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782682.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46900">
        <property type="protein sequence ID" value="OXR46900"/>
        <property type="gene ID" value="B7C42_00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="112" mass="12401" checksum="D6BB4338438DC408" modified="2017-10-25" version="1">MADYAHTDHASKGRAEKARRLAAYLWQRGVSGAELATIPAATRRKLARAADTNPPSTDETWTLVAQLLDEKDAWATRNPNHPAAQRVHTDEKILWIKPPVTPWLADDANPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDB8</accession>
    <name>A0A231HDB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dimethyl-sulfide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.13.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dmoA_2</name>
        <name evidence="5" type="ORF">B7C42_01733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.131" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46755">
        <property type="protein sequence ID" value="OXR46755"/>
        <property type="gene ID" value="B7C42_01733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="476" mass="52161" checksum="1C8EEBC7349D3C35" modified="2017-10-25" version="1">MTRRIRFNAFDMNCVAHQSPGLWRHPEDQSHRYKELSYWTELAKLLERGRFDGIFIADVLGIYDVYGGNDIAALRQGAQVPVADPLLLVSAMAAVTDHLGFGITTGTGFEHPFPFARRLSTLDHLTNGRLGWNVVTGYLPSAAANMGESEHLDHDERYNHADEYLEVLYKLWEGSWEDDAVVRDRAQGIYVDPAKVHHIGHAGKHFTVPGIHLSEPSPQRTPVIYQAGASPRGVAFAAENAEAIFVAAPSKRVLGQTVTRIRDALEAAGRDRYAARIYALATIITDATDEAAQRKYDEYRSYASVEGGLVFMSGWMGIDLSRYDLDDPIGEVNSNAILSAVAAFQEFDDDGREWTVRDIAAWAGIGGMGPVFVGSGASVADRLQEWVDETDIDGYNLAYAITPGTFEDIVQHVIPVLTERGAYPSEYVPGTLRNALFGAGDRLPDDHRGARYRLGGPGSTALPDEQVRPQAGVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDF9</accession>
    <name>A0A231HDF9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MaoC_dehydrat_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46960">
        <property type="protein sequence ID" value="OXR46960"/>
        <property type="gene ID" value="B7C42_00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="19001" checksum="1B011D03B2A0E4C3" modified="2017-10-25" version="1">MAEVDDSKPDEPTGSAFLFPVESGHIMMFARALGDDSPVYRDDSDELTRRRGGITAPPTFVAGAAQFDPDWPYRPRPGVPWHGSGAGPGTAPPSSGAGTSMQAEQHYQYHLPVRPGDVLRVERSAGRTWEKDSKRAGRLKFFEEITRFVNQRGELAVTARRVRVITEHPVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDS5</accession>
    <name>A0A231HDS5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47090">
        <property type="protein sequence ID" value="OXR47090"/>
        <property type="gene ID" value="B7C42_00212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009899">
        <property type="entry name" value="ArdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07275">
        <property type="entry name" value="ArdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="25399" checksum="1930A92DB711202B" modified="2017-10-25" version="1">MNERHPNNNAHSDTRPESARGPSDDEPTYREAEIGHEKDPPRYPRIYVTRGLPLRAELTDGAWIDMARDPRGIHAELYSMFGEQEVYDREGLYIWDYQGYASFRPSTGPLGLEGVHTIELLSAVAQGIIDYGPAFSAWASAHEDDPSQFSRFERAYQGHYESVDGYVRHLFAPLGLDEVLKGAFPDQLKHLAYIDYEAIGEQLLAQDDIVAVPAEGGGVWIFDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDZ1</accession>
    <name>A0A231HDZ1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47042">
        <property type="protein sequence ID" value="OXR47042"/>
        <property type="gene ID" value="B7C42_00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="75"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="45677" checksum="BEBC026F11AEE34F" modified="2017-10-25" version="1">MSFSWFISVDDHLIEPARLWQERLPEKWRETGPRIVREDKSEFWVYEDRQIVTTGLNAVAGKKREEFSPEPITYEEMRLGCYDPAARVADMNQGHVLSSMLFPSLPRYCGQIFHEAKDKELALLCVRAWNDFILEEFAQAYPGRFIPMMIIPLWDPVAAAAEIERTAALGAKSIAFSENPTKLGLPSIHTDFWDPVFRACDDTGFVISMHVGSSSNMIRTSEDMPTLAFMAYSAAANQAGTLLDWLFSGNFVKYSNLKIALSEGSIGWMPYFLERAEQVVDKQRFWASRFDISMNATHERGEQKGMATFDLDTDIRRLFRDHVYGTFIEDQAGIRLLDIIGEDNVMLECDYPHSDSTWPDTVQLAGKWLGHLPQDVQDKITVGNASRVYNFTPADPASIPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE35</accession>
    <name>A0A231HE35_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46967">
        <property type="protein sequence ID" value="OXR46967"/>
        <property type="gene ID" value="B7C42_00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="132"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="392" mass="44268" checksum="4F203A1C307DD8E1" modified="2017-10-25" version="1">MSNTELPVLDVDQHYYEPIDAFTRHCPKDWAARTVQIAKIGNRTRHIIADKVDYSVTNPTFDPIVKPGAMADYFRGNPEKKHLQEILSDREPIPAHYRDRDARLAKLDEQELNSIWLLPSLGMGFEERLQYDPPAAGQAFKAFNRWLLEDWGYNYRDRIFGSPYLAFGDIETAVAEVEHGLAHDARIFVVRAQAVYTDGGWRSPGDPIFDPIWARVQEAGATVVVHVGEVGGSGLDKYTDYHGNIIGDIASPLQIAVGHERAIANYLAAVTCDRLFERFSSLRIASVENGAEFLPLLISGLNRAGFQRPGYFASDPVEQFREHVWVAPFWEDNLTEVVHHMGADHVLFGSDYPHPEGLAEPRQYEKVATELKDPVSERKIMWDNAAKLTKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE40</accession>
    <name>A0A231HE40_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase</fullName>
            <ecNumber evidence="6">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">narB_1</name>
        <name evidence="6" type="ORF">B7C42_00276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47154">
        <property type="protein sequence ID" value="OXR47154"/>
        <property type="gene ID" value="B7C42_00276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="747" mass="80779" checksum="4B287961CD547F6F" modified="2017-10-25" version="1">MTEWHPTACILCECNCGIQVLLGADGRSFDKIRGDKLHPSSAGYTCNKALQLDRYQNGRTGRLTAPLRRNADGSFTKIDWDTAISEISARMREIGDEYGGESIFYYGGGGQGNHLGGAYAPATMAAYGMRYRSSALAQEKTGDFWVGARMTGHPVRSDVEHAEVALFIGKNPYQSHGFPRARSVLKEIARDPRRSIIVLDPVRTETAELADFHLQLRPGTDVYLLAAMAAILVRDDLVDHDWLAARTEGFDEVAAVLRTVPIDKYCALADVEIDLVTAATHRLAAADSVAALEDLGVQMNRHSTLVSYVEKLLWLLTGNLGKPGTQYAFSGMAAIGHDRGHPADSGPRSPVVGARIISGLVPCNVITEEILTDHPARYRAMIVESANPAHSLADSARMRAALAALELVVVIDVAMTETARAADYVLPAPTQFEKYEATFFNFEFPRNIFHLRHPVLPAPAGVLAEPEIHARLVEAAGVLTEDDYRPLRAALDQGREAFAMAFLAVLADPAKAKLAPILLYRTLGATLPDGAAAAAVLWGAAYTCARKNPSGVERAGYGTGLAAGERLFEAILTGEHGVVITDDEVGETWNRVRGGIVRLAVPELLSALAALPEPDEDRNWPFVLAAGERRAFTANTIMRDPAWRKRDPGGALRISTTDALRLGLTSGDQVRLTTRTGSARVTVEPTDRMRSGHLSLPNGLGLSVVEEGEVLTSGAAPNELTAFDERDEWVGTPWHKYVPARIDTVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEH6</accession>
    <name>A0A231HEH6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47097">
        <property type="protein sequence ID" value="OXR47097"/>
        <property type="gene ID" value="B7C42_00219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="7772" checksum="D2D699A24A7BEA3D" modified="2017-10-25" version="1">MGTPVAAVSGDSPQGMAEAFKRACIAVLLGVIAIYFAVTLVQSMWPALVAILGGIGLVAMVVGGIIIWRKMRAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEK9</accession>
    <name>A0A231HEK9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ORF">B7C42_00360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777091.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47238">
        <property type="protein sequence ID" value="OXR47238"/>
        <property type="gene ID" value="B7C42_00360"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="203" mass="22539" checksum="40161A856056AB91" modified="2017-10-25" version="1">MGGTFDPIHHGHLVAASEVANRFDLDEVIFVPTGQPWQKSTRQVSPAEDRYLMTVIATASNPRFSVSRADIDREKATYTVDTLRDLQNQHPDADLYFITGADALASILTWQDWAELFELAKFVGVSRPGYELNVDHLEGHLRNQPADAVTVIEIPALAISSSECRRRAAEGRPVWYLVPDGVVQYISKRHLYVPGGNGRVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEM9</accession>
    <name>A0A231HEM9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetracycline repressor protein class E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tetR_1</name>
        <name evidence="5" type="ORF">B7C42_00554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043444.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47431">
        <property type="protein sequence ID" value="OXR47431"/>
        <property type="gene ID" value="B7C42_00554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="27600" checksum="0259BCB21C78A94B" modified="2017-10-25" version="1">MTDREVPDHLARLWRLPVDAKLGRPAALDVDRVVATAVELADRDGLAAATLPKIAAALRVTPMSLYRHIGSKDELLVLMADAGMGAPPELPSGSWRSLLRAWALAQLDVHRARPWLTQLPITGPPNGPNTVAWMDAGLRAVRETSLDWPAKVGAIMVVSGYVREAFVTARQLEHAMAAADLDPAGALHDYSRNLRALVDRERLPDMAALLASGLFDAIEPAEAEPDSDFAFGLDLILDGVAATIAAATRSSGCGSTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF48</accession>
    <name>A0A231HF48_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azoB_1</name>
        <name evidence="2" type="ORF">B7C42_00629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47504">
        <property type="protein sequence ID" value="OXR47504"/>
        <property type="gene ID" value="B7C42_00629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="31625" checksum="35A097E24377CC01" modified="2017-10-25" version="1">MTVHDNLVLVTGATGKQGGATARRLLAHDVPVRILVRDPAAEAARELAALGAEVAVGDFDAPATLTAAVAGTRGVFLVPPAAFGPDGWDVELEAARGAAVIDAARNAGTDHIVFTGVASFDNEIPWGSAGKRQIEQALADSGMRYTVLRPVRFMENYLAQGLPLDGFVDGVNVHLFPADRPAQMIAVDDIAAVAALAFADPERFSGQTLELAGDAVPPTAAVELISRATGYPVRYREITEAEAGELGEQIANTWRLSHQGHGWHADIDQIRRIHPGLQSLETWLASTGAAVLKSRFAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFD1</accession>
    <name>A0A231HFD1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsO</name>
        <name evidence="7" type="ORF">B7C42_00785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503331.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47660">
        <property type="protein sequence ID" value="OXR47660"/>
        <property type="gene ID" value="B7C42_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="89" mass="10433" checksum="D297AA8E737642EC" modified="2017-10-25" version="1">MALTTEQKSAILKEYGLHEKDTGSPEAQIALLSKRISDLTEHLKVHKHDHHTRHGLLGLIGRRRRLSKYLQDKDIERYRSLIERLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFD9</accession>
    <name>A0A231HFD9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47559">
        <property type="protein sequence ID" value="OXR47559"/>
        <property type="gene ID" value="B7C42_00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11797" checksum="A35CDA258D718A19" modified="2017-10-25" version="1">MRALEHPSVDSVALPTLLQALADPVRLDIVCKLMQREAITCGGFDVPVSMSTLSHHLKVLRMAGLLRVIQEGSYRRNELRYDEIETRFPGVLSSILRNVHEGVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFN2</accession>
    <name>A0A231HFN2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_00642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47517">
        <property type="protein sequence ID" value="OXR47517"/>
        <property type="gene ID" value="B7C42_00642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="22467" checksum="6195B5DACF146FFC" modified="2017-10-25" version="1">MQGEADAARVLDAADRLFNERGIQGVGMDAIRDAADVPLKRLYRDFPSKTDLVHAVLTRRDNDVRTALARYVDDNASTPRERVLAVFDFLYEWFSGPDFRGCLFINTVGELGGTSDEVGRIAARHKRAVRDYLADLVTDCALPESVADQLLIIANGAMVTAAMHDDPEVARQARAVADILLRAARPVGERGDDCRRAASPRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFR9</accession>
    <name>A0A231HFR9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator protein VraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vraR_2</name>
        <name evidence="5" type="ORF">B7C42_00691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47566">
        <property type="protein sequence ID" value="OXR47566"/>
        <property type="gene ID" value="B7C42_00691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="26009" checksum="5AAA9C2F0B001991" modified="2017-10-25" version="1">MTVTELPNTAREFGDAHGRDSGRARVLVVCGEQIMRSGLISVLRGMPDVGWVGPAVNSEAALKMVAADKADVVVLDHCPSPRWDGPGLTQRLTAVRPGGEVGVVVVSDGTDSALLLRYLQAGARGLVSRRSSAVDLVSAVDAVVRGQAMLSPSITRLVLDATAPYLPAVAHKPVTALDSLTQREHEILILVADGLSNSEIAQVLHVSYKTVKFHVSNILRKLSVRTRAQAIVYLRPTVTIASRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG96</accession>
    <name>A0A231HG96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47746">
        <property type="protein sequence ID" value="OXR47746"/>
        <property type="gene ID" value="B7C42_00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="154"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="395"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="452" mass="48743" checksum="8317E8BDB01314D0" modified="2017-10-25" version="1">MGFETANVVDFPQADVFEWFTRPGALTRLAPPWQPVRVVREAGSLKDGRAELALPGNLRWVARHDPVAYDPPHRFADELVAEGPASAFAHVLQWRHTHGFEAVDAGRTRIVDEVDTPVPAALLRPMFEYRHRQLAGDLAAHARAAQNGLRSSTIAITGASGLVGTALTAFLRTGGHRVIRLVRGPARGLDERQWDPSAPAADLLAGVDALIHLAGAPIAGRFTDEHKRRVRDSRVEPTRALAELAARIGLPTFVAASAIGYYGYDLGDRSLTEDSPAGDGFLAEVVSAWEDADRPAREAGVRVVRVRTGLVQSPAGGLLRLLRPLFAAGLGGPIAGGRQWMSWIGIDDMIDIYHRALWDTALSGPVNAVAPHPVRNAEYTRTLARVVRRPAILPVPQAGPALLLGGQGARELAAASQRVEPTRLLAAGHHFRTDRLEPALRHVLGRLEAPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSJ2</accession>
    <name>A0A231GSJ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000315">
        <property type="protein sequence ID" value="OXR39576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39576">
        <property type="protein sequence ID" value="OXR39576"/>
        <property type="gene ID" value="B7C42_08356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="7838" checksum="8479A479EEDF2AEF" modified="2017-10-25" version="1">MRQHTEAEADLPVVTVWIDSPTEQVRQRMIARGSARDAPKLADWTGYRSGVLDSGVRELARTVCDLVIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSX5</accession>
    <name>A0A231GSX5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000087">
        <property type="protein sequence ID" value="OXR39682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39682">
        <property type="protein sequence ID" value="OXR39682"/>
        <property type="gene ID" value="B7C42_08247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8507" checksum="1FD51EFC8A8FC3E8" modified="2017-10-25" version="1">MEFHAFLRPSFQTVLTRNRTGFAAASRRPSQIDLMPSIPSWNQPRTLSTPSWIFGNTVPVSQSTPLPSESFRSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT69</accession>
    <name>A0A231GT69_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782220.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39824">
        <property type="protein sequence ID" value="OXR39824"/>
        <property type="gene ID" value="B7C42_08112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="17180" checksum="D000704DA76D8F24" modified="2017-10-25" version="1">MSHDACGHCGNVHTSGDPYALIEQYRDQYAAAPNLTPAAIDDIFALARCLHSQLYEAVADLHNLRLGFGRTDGRVEESGTRFAVRRRDGKIIESPAPDLAVSRFDNMNAQAVDLGFESADAEVVRRNWALYVEDWTALPPSDIEQYRLDDEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTE8</accession>
    <name>A0A231GTE8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782312.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39889">
        <property type="protein sequence ID" value="OXR39889"/>
        <property type="gene ID" value="B7C42_08035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="170" mass="16624" checksum="E336B72DC436D581" modified="2017-10-25" version="1">MPGNKYIKLDTTTGNLTEQAAVQTSAGAGDAGKIPALDSSGRLDNSMLPVGIGADTATITASEALAAGDFVNIWNSTGPKVRKADATTAGKEAHGFVLAAVSSGASATVYFEGTNTGVTGATAGPVFLATTAGTATSTPPSGSGNVVQRLGVAVSATAINFEGQPPVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU25</accession>
    <name>A0A231GU25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">suaB</name>
        <name evidence="2" type="ORF">B7C42_07942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779232.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39991">
        <property type="protein sequence ID" value="OXR39991"/>
        <property type="gene ID" value="B7C42_07942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010693">
        <property type="entry name" value="Divergent_4Fe-4S_mono-cluster"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06902">
        <property type="entry name" value="Fer4_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="7679" checksum="DAE95B36190B78C2" modified="2017-10-25" version="1">MTYDIRIDTEVCIGSGLCLAARPDVFDINDDGVAEVVAGSPAIPGDAQIAIARGCPSGAIRLHDIASGDEIDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU89</accession>
    <name>A0A231GU89_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40193">
        <property type="protein sequence ID" value="OXR40193"/>
        <property type="gene ID" value="B7C42_07707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="10118" checksum="C16AF15A527E9DFD" modified="2017-10-25" version="1">METSLNGAVAVGATALGATAVAFGVAGLLAFGPRHDVAPAAVEHTTGKPGCVMFCDEPAPAAPDSHGCTLFCSEPSLPPANQQGCQLFCELETSKGEYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU98</accession>
    <name>A0A231GU98_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000039">
        <property type="protein sequence ID" value="OXR40148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40148">
        <property type="protein sequence ID" value="OXR40148"/>
        <property type="gene ID" value="B7C42_07772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="25797" checksum="685A7674892EF666" modified="2017-10-25" version="1">MSRNSSRGGTKGDSSPGDSACMAEQQQPIAVGLVREDVSGLRLPEHVDKIRRHAEKMSYAYIYTVRAPGNLTDPVGYALGIASASSAAALVVYDLETVDHTPSRVCGMLDLETISPPATWAVAMPHAAGPPHSHPEHPLTVDSAHMIMQQHLDCRTFECPRKATAYSCLVRAGKIVPPVDSPRERAAARGLPFRPRRHGRGSLPEGVSLTTLLDVLGGLTDLESEAGASANADQVTGSTATGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUA5</accession>
    <name>A0A231GUA5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40125">
        <property type="protein sequence ID" value="OXR40125"/>
        <property type="gene ID" value="B7C42_07789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="7830" checksum="6D46E7A4C1131C25" modified="2017-10-25" version="1">MAKLISSHPRVASRLRHIRIEAGALTLDYKASAEQARDVACALTQLSPDLMVTVDDDVCRDLPPLPCAGLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUB4</accession>
    <name>A0A231GUB4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">thrC_1</name>
        <name evidence="15" type="ORF">B7C42_07721</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042076.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40206">
        <property type="protein sequence ID" value="OXR40206"/>
        <property type="gene ID" value="B7C42_07721"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="38"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)" evidence="13">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR40206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="37472" checksum="861C1AF051D9ADA8" modified="2017-10-25" version="1">MSQTGAPPSAGAVHTPWPGLIAAYRERLAVGADWEPVTLYEGGTPLVPAHHLSELTGCEVYLKVEGLNPTGSFKDRGMTMAMTDAKARGQKAVLCASTGNTSASAAAYATRAGMHCAVLIPQGKIAMGKLAQAVMLGAKIIQVEGNFDDCLELARKVTSDFPEVGLVNSVNPARIEGQKTAAFEICDALGKAPDVHALPVGNAGNITAYWKGYSEYHADGLTASRPRMLGVQAAGAAPLVNGAPVKDPETIATAIRIGAPASWNSAVAAQEQSGGAFRAATDDEILAAYRLVASTEGVFVEPASAASVAGLLAARKEGWLDSGLTVVCTVTGNGLKDPDTALLGMPAVEAIAVDPVAVARELELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUW9</accession>
    <name>A0A231GUW9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tmk_2</name>
        <name evidence="2" type="ORF">B7C42_07606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909898.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40345">
        <property type="protein sequence ID" value="OXR40345"/>
        <property type="gene ID" value="B7C42_07606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22408" checksum="28E9CA8076DC0E3B" modified="2017-10-25" version="1">MLIALEGIAGSGKTTLRDRILHLAEHSGIPVRHIGQFSWLSPAATRTLVAMRTGRAIVDELDAVAAVLDDLTLHAHHNIAAAARDGHVLADRLILSSACLLGLNYPGTVARHLEPLVRVTNALPDLTVLVTTPVEVCAARLAARPTAQRVGDDSGTATRLHELYQRCADLWPHGTGRPLLRQPLNTFEDTEQLARQLLDELEKVGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUX0</accession>
    <name>A0A231GUX0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40368">
        <property type="protein sequence ID" value="OXR40368"/>
        <property type="gene ID" value="B7C42_07534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22196" checksum="9A083FDA02F6DFA4" modified="2017-10-25" version="1">MDTTEVSKADEDDAVVSVEPDASTTEATGPGAPREAEPAEGNAVPKWRRWLPRPGTAVLIVLLVAATAGCVVFGSKFRTLHNREDAGRAASAAAQDYAVALTNIDFAHLDADTATVLNGATGEFEAMYRQSAEQLKPVLLQAKAVSKGRVVAASVQSESENHAVIMLFVDAEITNVTNPQPRLDRNRLLMTMDRVDGRWLASKVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV22</accession>
    <name>A0A231GV22_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40428">
        <property type="protein sequence ID" value="OXR40428"/>
        <property type="gene ID" value="B7C42_07486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="8320" checksum="931AB7356FDF7D32" modified="2017-10-25" version="1">MEGQDIHSSDWAEQDLLTRELAVQRLNQEEASTKAELHRERSQPNSDPDAIKLLEQRLRALAASRKNILELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVB8</accession>
    <name>A0A231GVB8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF222 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40495">
        <property type="protein sequence ID" value="OXR40495"/>
        <property type="gene ID" value="B7C42_07433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="2">
        <location>
            <begin position="13"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="498" mass="53170" checksum="6F5E53DEA55AA275" modified="2017-10-25" version="1">MSDEGLVDALRRAHGAAAFAQAAEVRAVRELYRRHRAGNAAPGPGGVRAGEFAAAEVAMAVQVSEQVAAALIDIGLALDALPHTREAFGSGRIDLSRVQVIVDNARGLSSDLLADLEVPLVEAAARTTPARLRQTARRWLSRLDGPGEQRRREQREECRDIRLTAVQDGAAVVAGLLPADGAQTVATRLRDMAHEVCPADPRTMPQRRADALVALAEGAERLDCACGRGKRCTATVSGHPASDARRTSGRAGTRRPLIQVGVSAEALSGDSEEPAYLAGYGPIDAELARRIAERGESVSIAESAMRIDGLCAFPGCVMPAATTDVPAPEGSTGTTDVDRFGDAVRGPRNRHGAVESQSPRLEAADPHSDRHAAARAPHSSSPGRQSMALCPHHSRLALLTVQHRTRWEVRRLDANRVQWTSPTGDVHTTVDEVARYLFPHRDTETPRVGAGPVSTSVVAWPVSTLDPAYPIGDHALVHRRLAEGTPEDCLLAGESYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC5</accession>
    <name>A0A231GVC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40564">
        <property type="protein sequence ID" value="OXR40564"/>
        <property type="gene ID" value="B7C42_07373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234766" evidence="1">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="28835" checksum="19ED72E1A31A2C3F" modified="2017-10-25" version="1">MLRTRGTRFALSVLALTAGATLAASTIAVAEPAPKPQAADVPLVPEGVPVDAIASLAPAIVGAAAQAGNIASPGAQTILDQAIQLLDRAGLPPQVKQTLQAIVAFLDGSGGGGPDIPKNGPAIAQFLYPTIGKNCIGPGSDSVGTALAVPGPAELPPPGPAAGQAGFVFTALGTKGLTPQQNPPMTVQWYNLDNHRGGTVALTDEAHINPDGPATLSAIVDTGPGRVISVVAGSLTTQPAADQAPITCSFLPTLGLFTVAAGPAQAAAPVNPAGTVPAAHVVQQPAAVRPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVV9</accession>
    <name>A0A231GVV9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40754">
        <property type="protein sequence ID" value="OXR40754"/>
        <property type="gene ID" value="B7C42_07178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189490" evidence="2">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="275" mass="29514" checksum="4FE378882FC05573" modified="2017-10-25" version="1">MSAIFALTMPSAVAAAEPAPMEPNASPAACSLAATSETRTINDQPYLLRVPSGLTGAAPLLIALHGGGSNPTTYENQSGWTPFAAQHKFIVAYPLGGKKDVPAPNRSWYFENGNRTDVDFLLKVIADIEGYRCVDTKRVYMTGHSNGGQMTSRMACAASAQLGAVAMYAGGSHGGCEDGVPIRKLSFGFFTADNDFTQAPVYAAHLQWRGTIGCSNDAATETGPEVVEGYRYSCEQGANVVWRKYKAGSHDWPSGDRGADVRDRMWQLFQNHPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVW0</accession>
    <name>A0A231GVW0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064902012.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40621">
        <property type="protein sequence ID" value="OXR40621"/>
        <property type="gene ID" value="B7C42_07306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="36430" checksum="1714425C48449D7C" modified="2017-10-25" version="1">MKSPAVTTDGMARVSGRRPVDLQRSAGRLLKASAEKFYDAEVDIDWESPWMPDKGWFPEHRLSLYGTSLWNRLSDEQKIELGKHELVSILSFGIYAENLLSMALLRLNTTGDLVDNKALYALAEVGDESRHSTMFARLILKTGIAPYKLPRGFLSLAKILHFIPLGPSIQGATLLIEEILDRAQREAMNDERLQPQVRQLMRIHVLEEARHITFARSELVEGMRARGRFTRAWHRGALAVIANLAYPILINPRLYRTIGVHPLRGFIACQFGPHYRENLQFMSEPMIRFFDDAGMIEGRFTMFLWRLTRSLPEDIAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW57</accession>
    <name>A0A231GW57_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase, short-chain specific</fullName>
            <ecNumber evidence="8">1.3.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bcd_4</name>
        <name evidence="8" type="ORF">B7C42_07092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40808">
        <property type="protein sequence ID" value="OXR40808"/>
        <property type="gene ID" value="B7C42_07092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004085">
        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="141"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="253"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="44034" checksum="C8B671E0E7C7AAEB" modified="2017-10-25" version="1">MINLELPKKLRASANQAHQVAAEIFRPISRKYDLAEHEYPVELDTMAAMVEGLADSGTQDISGATGGRKAKSGEDTGDSHATELLGNSNGGNMSALLNALETCWGDVGLMLSIPYQGLGNAAIAAVATDEQLERFGKVWAAMAITEPSFGSDSAAVSTTAVLDGDEWVLNGTKIFVTAGSRATHIVVWASVDKSKGRAAIKSFVVPRDAKGLTVARLEHKLGIKASDTAELRLEDCRIPADNILGSPEVNVEKGFAGVMQTFDNTRPLVAAMAIGVGRAALEELRAILEESGVEISYDIPANNQSAAAAEFLRMESDWEAAYLLALRAAWMADNKKPNSLEASMSKAKAGRMGTDVTLKAVELAGAVGYSQRTLLEKWSRDSKILDIFEGTQQIQQLIVARRVLELTSAQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWB3</accession>
    <name>A0A231GWB3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782169.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40852">
        <property type="protein sequence ID" value="OXR40852"/>
        <property type="gene ID" value="B7C42_07136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="14282" checksum="762E8497484C388B" modified="2017-10-25" version="1">MTNPSVMQGGSEDWNSGATKTAVALGELENQLRTLDATRHGLNTAVQSVHTGNAIDSSLSNVHASGKRLAAELQRILDNLKHRGGSVQVDDLHGAAKVLAADGNDGSLNVTDGSGNYQYAGAPGTDMVSGKIRTSDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWH9</accession>
    <name>A0A231GWH9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40987">
        <property type="protein sequence ID" value="OXR40987"/>
        <property type="gene ID" value="B7C42_06953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="19651" checksum="09C6331FB32187A4" modified="2017-10-25" version="1">MQRDGDSSDLPPESRTSGPGRVGSERGDASAAEPGGSANTAEAPDISAPEDPRPSGATFERRPPGSIPRPARASAGYFPGEDKHPVLITEAAPSLDQQHRARVKRYMILMGFRIPCLVLAAAAYGLWSNALISLAIIGVSIPLPWIAVLIANDRPPRSKDEPSRWDERRAAKALESGQHRSIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWR8</accession>
    <name>A0A231GWR8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">lexA_2</name>
        <name evidence="12" type="synonym">lexA</name>
        <name evidence="17" type="ORF">B7C42_06981</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779454.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41015">
        <property type="protein sequence ID" value="OXR41015"/>
        <property type="gene ID" value="B7C42_06981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="16">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="15">
        <location>
            <begin position="138"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR41015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="27058" checksum="9F999972D3CD1231" modified="2017-10-25" version="1">MSERTVVGHEEAAGNGTASPDGAQAPGGDTETPGNGADLTVRQRKVLEVIRTSVNERGYPPSIREIGDAVGLTSTSSVAHQLRALERKGYLRRDPNRPRAVDVRGLDETAVRAAGAAPVLRAVATETSDATPAPTYVPVLGRIAAGGPILAEQAVEDVFPLPRELVGEGSLFLLKVVGESMVDAAICDGDWVVVRQQNVADNGDIVAAMIEGEATVKTFKRTGDQVWLMPHNPLFDPIDGNDAQILGKVVTVIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWZ2</accession>
    <name>A0A231GWZ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoid occlusion factor SlmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">slmA_4</name>
        <name evidence="5" type="ORF">B7C42_06862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41092">
        <property type="protein sequence ID" value="OXR41092"/>
        <property type="gene ID" value="B7C42_06862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="21778" checksum="C519853552EEF4DA" modified="2017-10-25" version="1">MSADERRADRRVRLVRAARELLESGDTAQVTVTAVCRRAKLSERYFYESFTDRGALLGGVYDDFADEYIDAVTARIASAGDLTDRIHASVTVAPELAATYPGMRHVLGRDADEGEAARARAHIARKVIDLYLANRALLFRDIDIDPLDAELAVRIMVGGGLDLAFAYCQGRFDVSAAELATRTAKLLEPLTESLSSGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX13</accession>
    <name>A0A231GX13_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41160">
        <property type="protein sequence ID" value="OXR41160"/>
        <property type="gene ID" value="B7C42_06756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="34870" checksum="12F7D893849F9138" modified="2017-10-25" version="1">MTTSIDTLTQWVEQHAHPLPASDPEQPLTDPAALRQMIGAARVVALGAATRDAHELSVTAHRILRFLVEQSGFRSLVLEGDDATSAALDAYVRTGIGDPRALLTEARSFWRTEEILEVVAWIRRYDELHPDDPVRIAHPEPEGRVTAGSGDLGDIERMLADNVIRWHTDTGHKIVYWGGTTHTVAAAARNVLLGEQRVIHRSAGGHLRQHFGAGYLSVGLTFDHGSTAHTFPSPPADFAEAVLGRVELDAYLLDLRAPGPDSVRTWLTEPAKTRVIGPVYDPDNDDAFHLSGGSLGEWFDLVVHHRTVTSIRPLGSPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX45</accession>
    <name>A0A231GX45_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41176">
        <property type="protein sequence ID" value="OXR41176"/>
        <property type="gene ID" value="B7C42_06772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="842" mass="91369" checksum="787BD223430C9532" modified="2017-10-25" version="1">MAFVRDLQPTAAVRGNLQFTHAGLVTATYFINPLGYGLRRSSDKHNVKSAHHALVNSLPAGSLLLGIQARLNTLDVLSKMVEGVDLDECEDYALEVVASYERVQAILPQTRIFLLSIPVGNAGAGISGLSRMWRGGSTAVDVSSISRESLDQYDEKANEILSRIGGDFDPVPVPAAIFQWMWEHYLSRGAAGDPVAPTRAGVVDDATAAVFRSAALDEGAQADSSRRVRPSFVPVIKVVQPDYEFRPSYQAMLTPHAFPYGGMPFPGGSEFLGVLEGLDDVTVDWAMRVSTKPAEAVLKSNELNLRRLGEQMDQRDQEISFAQNTLMSKASMLAEYNHHFEVNSGESEVSFTTVIAVGSDSHETTMDAVNTLKRRYKRFQVEMTAPLGAQVDLWSMMIPGSPHRRAYDDFAHILPSDMWAGFVPFTTSQIGDDSGPVIGVNLLSGNYEPIHFGIMEAALHDLSASFAVTGELGSGKSYFLKLMAVLVHDMGGQFLAIDRSQVGEWEYFAASIDNAVVIDLSNPTVSLDPLRLFAPRVAGERTLDSILPLLDLSPTSGAGAAMSSLLTPRGIAEHGIRSMLDLHDVVCRLRDSGAGDEFADLAARLGTILDRVPVLFDPTLPVLRLDAAATVVRSHNLALPTAEELTTPHLYNRLPLTKRLGTALYELVGVAAREAFLSDNGRFGLLVGDEAHHFTQTHVGSAVTSDFSRDGRKHLAAIGLASHDPATDFQGAAHNLIPNRFVFRQRDETLARNSLQWLGVDLDETPFLLQVLREETSPPSGPGRTVPDERRGEMFMRDALNRIGRGKVFGPARPDRAEAIGSTPQTAGAGARRSAVARQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXD7</accession>
    <name>A0A231GXD7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodocoxin reductase</fullName>
            <ecNumber evidence="3">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thcD_7</name>
        <name evidence="3" type="ORF">B7C42_06678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41280">
        <property type="protein sequence ID" value="OXR41280"/>
        <property type="gene ID" value="B7C42_06678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="324"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="44178" checksum="98D0168025AB8D0B" modified="2017-10-25" version="1">MTAATGRSDSVVIIGAGHAGATLAGLLRQQKWAAPITLIGEESHPPYHRPPLSKKFTDDTMVQLLKPAHFYPDNDIELLLGVRATAVDVAARRVGLDNGEHRDFATLVIATGATPRMVPVPGAEAAGISTLRTISDAQRLGSALDAGVTLAVIGGGYVGMEVAAVARSRGVDVTVIEREDRILARVASAELSRRLTEYHAARGTRVVVNCTVAEFLAADGALTTVVAQDGTSIACDHVLVGVGAVPNVELAQQCGVACDGGVLVDRAGRTNVPGIMAIGDVTRRPHDALDGLYRLESIPSAVEQAKHAAAAICGTDGGVHETPWFWSDQFDLKLKIAGLLEAGTRTIVRAGESPESFGLFHQRLDRTVCAVETANSPKDFMAGKKLISEGVPVDPDLLADAEVPIRDLLRDGSPTRSVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXH4</accession>
    <name>A0A231GXH4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyltransferase plsB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plsB1</name>
        <name evidence="2" type="ORF">B7C42_06680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41282">
        <property type="protein sequence ID" value="OXR41282"/>
        <property type="gene ID" value="B7C42_06680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GPAT_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GPAT_C" evidence="1">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="18938" checksum="7BD4EAB0C7BC2237" modified="2017-10-25" version="1">MIERAIVEVAVQGSCTTNGAATALDDARRLRDLLKFEFFFAGRTEFVAALQSELDLITDGNTDSASIDEATAEQCLDRVDLLVAPLMLRPFIDAYAVVAHQWALQRRNASAESTSAEMFHTALRLARHLGLLDGEQPGLRQRRAEFRREIRAIKDRIEQLSRRSIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXL0</accession>
    <name>A0A231GXL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">drrA_12</name>
        <name evidence="6" type="ORF">B7C42_06479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043079.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41336">
        <property type="protein sequence ID" value="OXR41336"/>
        <property type="gene ID" value="B7C42_06479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="34655" checksum="DBC6D9FE8A781756" modified="2017-10-25" version="1">MSSAIEVRTLHKHFGSVRALDGLDLEVAEGEVHGFLGPNGAGKSTTIRILLGILARTSGQARVLGRDPWTDAVDLHRDIAYVPGDVTLWPSLSGGETIDLLGRMRGGIDTGRRAEMIERFELDPRKKARTYSKGNRQKVALVSAFSSNARLLLLDEPTSGLDPLMEQVFRECAREAAERGATVLLSSHILSEVEALCDRVTIIRAGKTVESGTLAEMRHLSRTSIKAELIGDPGDIGAIAGVEDVTIEDHTLHCQVDSDHLGELIRVLGDAGVRSLVSQPPTLEELFLRHYSLGGDAPADARRPAHTAAPRDEQALSEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXZ4</accession>
    <name>A0A231GXZ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carnitine operon protein CaiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">caiE_1</name>
        <name evidence="1" type="ORF">B7C42_06544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41401">
        <property type="protein sequence ID" value="OXR41401"/>
        <property type="gene ID" value="B7C42_06544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="18591" checksum="A0EC30E650B164A6" modified="2017-10-25" version="1">MPCYEFEGKRPQVDPTAFIAPTATLIGDVRVEANASVWYGAVLRADLAPIIVRERANVQDNTVIHTPPDVPVEVGPGATIAHSVVLHGASVGAEAIVGNGSTVLDMATIGAGSMIAAHSLVQPGTEIPAGVLAAGAPAEVKRPIAGTQAEGWVKINPGYYADLAQRHRKGVREIDSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYI4</accession>
    <name>A0A231GYI4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor BepR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bepR_4</name>
        <name evidence="6" type="ORF">B7C42_06273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41632">
        <property type="protein sequence ID" value="OXR41632"/>
        <property type="gene ID" value="B7C42_06273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="23437" checksum="955B47208CEF4EC5" modified="2017-10-25" version="1">MPRQHTEPTEPPARTRGRPRSGVREAVIAAAQEVLTSSGVARLTTKEIATRAGVAESSIFYHFGDRTGLLQAVIQHHLRPLKDMLADPPHSADEAESPDLRTDLVRLVMVLEDFFRAALPVIAAIESDAELRAVYSERSRDFDLGPHRALDVVIGHLSARHHIVAEPRTAALLVVGAAHQRALQSRMSPPEARAALPSPEAIADTALPLFRAEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYK0</accession>
    <name>A0A231GYK0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41601">
        <property type="protein sequence ID" value="OXR41601"/>
        <property type="gene ID" value="B7C42_06242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="4887" checksum="55B4FE7E918F4513" modified="2017-10-25" version="1">MRSAPSETGAVRGTAQRLFTATATTPPSPPAWAVMVGIARPPTGHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYT1</accession>
    <name>A0A231GYT1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mscL_1</name>
        <name evidence="10" type="synonym">mscL</name>
        <name evidence="12" type="ORF">B7C42_06109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780813.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41767">
        <property type="protein sequence ID" value="OXR41767"/>
        <property type="gene ID" value="B7C42_06109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR41767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="151" mass="16384" checksum="A86079E4F8541D7C" modified="2017-10-25" version="1">MLKGFRDFLLRGNVIDLAVAVVIGTAFTAVVTAIVTGIVNPLLDLFGGANEHGWGFYLDSSKPSTFIALGPIVTAVVNFILIAAILYFILVLPAGRLMKRYGTEKEAVMTEVELLTEIRDLLSEGSKSAGGRHEFADVDSLRRQGDTQRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZC9</accession>
    <name>A0A231GZC9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41963">
        <property type="protein sequence ID" value="OXR41963"/>
        <property type="gene ID" value="B7C42_05947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012489092" evidence="1">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="31522" checksum="3076BD85EB58A69B" modified="2017-10-25" version="1">MRLRASTLTVLAAVGIAAAAFAPAAAGPPLPGTVDLPCAAATLHQDAAWYRPAGTPRGMVWLQHGFARTEGNVAALAETLSDAGYLVFSPSLPFLNPDGCTLQNLGDNTAFLDQVARLFATAADPTGPLATSAARAGVGLPALPRRVVFIGHSAGAEAVEYVAHRLHASYPDAWANLRGLVVLDPVKSFLGTNTDTALIDLAATDLPVLTVSGPPALCNNFGSGTGALRTYLHRPFLGVRLITGEHTDAEGASTDTLGELLCGTPQPDNVAALQQLTVRWTGDYFDGSTDYPADAAVAAAEPLTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZR9</accession>
    <name>A0A231GZR9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42098">
        <property type="protein sequence ID" value="OXR42098"/>
        <property type="gene ID" value="B7C42_05697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="62" mass="7207" checksum="7068656660A530C9" modified="2017-10-25" version="1">MRAKKIRELEASDLPEADKPLWRDAMLRETRAGEWIDYRHQPWAAPALVNFTDAERTSILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZS8</accession>
    <name>A0A231GZS8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42116">
        <property type="protein sequence ID" value="OXR42116"/>
        <property type="gene ID" value="B7C42_05715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="14394" checksum="36B40ED1F73531EE" modified="2017-10-25" version="1">MAGYSGAPLARKLGIRPGSRVLLAHAPSGFALGPLPEQVSLQRRAGRGQYDVIVGFCPDYQSLHRGFGTWRACLTQAGGLWVAWPKKSSGVATDLSDSVVREFGLAAGLVDNKTCAIDDTWSGLRFVLRLADRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZY6</accession>
    <name>A0A231GZY6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase-2 operon protein HybG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hybG_1</name>
        <name evidence="2" type="ORF">B7C42_05775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036510650.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42176">
        <property type="protein sequence ID" value="OXR42176"/>
        <property type="gene ID" value="B7C42_05775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8279" checksum="A7C33A4122323415" modified="2017-10-25" version="1">MCLGIPGRVVEIVDGYGGQLALVDVSGAERKVNIGLLEDDPVAPGDWVIIHMGLAVERTDEAGAREALAGLRLLSRGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0K8</accession>
    <name>A0A231H0K8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ftsL</name>
        <name evidence="3" type="ORF">B7C42_05582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780667.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42382">
        <property type="protein sequence ID" value="OXR42382"/>
        <property type="gene ID" value="B7C42_05582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="217" mass="24110" checksum="7DCF8B53768AC542" modified="2017-10-25" version="1">MTERRARGTSPAGRGDRRSTRSPRPERAANGSTRTSAGKRAAQRRPAGTKSEPRTTRAKSKKSEDRHDHRILGLSTGRAVILAAVLCALALTLAVPMRTYFSQRSESVQLAEQRRDLENDLTRLRDRRAQQEDPAYIRSEARDRLRLVMPGDTAYIVQVPGIEQPAVPVPTSQARRPDPWYTQLWRSMSEPQPTPTTPAPPPPPPPAPPPPPEGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H181</accession>
    <name>A0A231H181_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DegU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degU_3</name>
        <name evidence="5" type="ORF">B7C42_05388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42610">
        <property type="protein sequence ID" value="OXR42610"/>
        <property type="gene ID" value="B7C42_05388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="22871" checksum="4C9CC64432F8F09E" modified="2017-10-25" version="1">MTGPVRVLIADDHAMFRSGLRAVLDAAPGLDCVGEAGDGRTAVAETARLRPDVAILDIRMPKLDGLAATEAIVAAGGTRVLVLTTYDSEAGLARALQAGASGFLLKTLPPEELIAAIRVAVRGDAIIDPSMTRRLAARLAATLAPAPPPDHALTAREQQVLLLLADARSNSEIAAALGVGEETVKTHVSRILAKLQVRDRIQAVVYAYRHGLVRSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1I9</accession>
    <name>A0A231H1I9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_05013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776823.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42677">
        <property type="protein sequence ID" value="OXR42677"/>
        <property type="gene ID" value="B7C42_05013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="26030" checksum="61ECDDECC95EAAB5" modified="2017-10-25" version="1">MVLLQEPATQSALESGPVQAGRSLTLRDRFKLPMTYSYGALLIAVTVLVSVLSDTQQTRVIQHASTNLHNLLAGRFGTLFSSAFVIGDGTAGAVLIPLLVCLLILAEWRFGALSLLRIFIAGHIGATLVVAGGLWVAVSVKWLPTSISLAEDVGVSYGAMAVIGSLIVVLPAKWRPTWAISLGAVAVAGVIMGHTFTNVGHLIALTIGLLTGWLLLRSGHVHAHRLNRFEMGLLVVAAALGYILLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H200</accession>
    <name>A0A231H200_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrD_1</name>
        <name evidence="13" type="ORF">B7C42_05204</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42866">
        <property type="protein sequence ID" value="OXR42866"/>
        <property type="gene ID" value="B7C42_05204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="15"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="371"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="883"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1199"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1217"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR42866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1243" mass="132279" checksum="7675681477891AAB" modified="2017-10-25" version="1">MTITPEQLAQALGLPPPTDEQSAVIAAPLGPTLVVAGAGAGKTETMAARVVWMVANRLVAPDAVLGLTFTRKAAQQLTTRIRTRLARLAGSPLLREIDSTGRLRATLVGSEPEISTYHSYAGRLLSEHGLLLPVEPSATLLTETQLWQLAHRVVTGWDGDLDTERTPVSVTEAVLALSGQLAEHLVEPEQLAVAHRELERLVETLPPGPRQRGGPNQELRGIVKAQQDRVALLPLVARLGEELRRRGALDFGSQMSLAARLAATHAEVGAAECERFRLVLLDEYQDTGHAQRILLAALFGDRGAVGIGAGARETDFATRPAVTAVGDPMQSIYGWRGASAANLPRFTTDFPAAPNVAAPVLPLLTSWRNPPEALDLANLVAEPLRGAEGGVTVDALRPRPQATAGTVALALAETVADERKWVAERIAAEWEQCADAGRPPPTSAVLVRRNADAAPLAEALRARGLPVEIVGLGGLLATPEVADIVATLRLIADSAAGSAAMRILTGARWRLGVSDLKALSARARELSIVGTPGRAEPITDAAGLSDALRAVAPEPAEQAGIADAIADPGPAQRYSELGYARIIALGRELAALRERSGQSLPELVADVERTIGVGVETQTRRAAAGAGAGREHLDAFADVVAGYAGDHRATLPGLLSFLAAAEEVENGLEPGEVEVAHDRVQVLTVHAAKGLEWEVVAVPHVSRSLFPSGNAAATWLGALAELPTSLRGDRQRDDDGDTTDSAPARDGVPVLDLSELYDRTDLERAIKQHKEALARRRLDEERRLFYVALTRTERALFVSAHHWAETGSTPKGPSDFLLELKRWTEHPESPGHGTVRVDLWADPPPPDAPNPFTDNPAVADWPRDPLGVRRRAVEAGAALVRTALAHLPPETREPRTQPANGRAAPARAEIPPVPSRRAHDATSELESSRQLDLFADLTHDPEASGTDGTASGNGAEDGAAPDHDPDPEGWADDVDALLTEHFATVEGIHEVELPAQLPATALVDMRADPAKLAARLRRPLPYPPSPLARRGTAFHAWLQRWFGAVGLLDFDELPGAADSGAGDADLVRLQEAFLASPWADRNPIDVEVGFETSIGGTLIRGRMDAVFSEPGGRWLVVDWKTGAEPARAEERSVAMQLAVYRVAWARMMAAQTGEAEELVLDKVGAAFHYVRSGRTVAPAELPGPAELADLIAEVAPAWAPPADPREGAYPELAGDLPPDEEYGDELPPDPVSDADFDPDYPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H202</accession>
    <name>A0A231H202_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42875">
        <property type="protein sequence ID" value="OXR42875"/>
        <property type="gene ID" value="B7C42_05213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189492" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="11627" checksum="076A440F36D6C6AF" modified="2017-10-25" version="1">MNNIVTLASRSVVAPMVSVVSASRGVLAMQGTGLSVASIIGARPQAPAYAIAADKSEWGWHQAHIGFHTDAAHAFAVEADRMTANLQAVRLRNAHPATVISSRHRSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H206</accession>
    <name>A0A231H206_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780157.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42884">
        <property type="protein sequence ID" value="OXR42884"/>
        <property type="gene ID" value="B7C42_05222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="477" mass="50848" checksum="A10AD747082916CC" modified="2017-10-25" version="1">MSDVPFGFSNRDDDPDRDKRDDQAGSGANNPFAFGMGSSGAAGFDPAAFGQMLTSLGQMFSTMSQPGGQASPVNYDVAKRLARQQLGSTVAPITDGAQRAVSDAAHLAELWLDAATTLPAGATKTVAWSPNDWIEQTLPTWKRLCDPVAEQVSGMWSSTLPEEAKQFAGPMLGMLGQMGGLAFGSQLGQALGQLAQEVLTSTDIGLPLGPAGTAALLPSAISEFSKGLELPESEILVYLAAREAAHQRLFAHVPWLRQQVLGAVEDYARGIRMDFSAIEEAAQNIDPMSLTDPSKLEELLSQGTFEPQTTPEQKAALERLETLLALIEGWVQVVVAEAVGDRLPGAGALAETLRRRRATGGPAEQTFATLVGLELRPRKLREAATLWQRLTTDAGMSARDAVWAHPDLLPSSEDLDKPSGFIDGVIGGGANVFDDPLAQLAETEARERREGAAAQQERPNEDSDGDTGDERGENEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H221</accession>
    <name>A0A231H221_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiB_3</name>
        <name evidence="2" type="ORF">B7C42_05215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42877">
        <property type="protein sequence ID" value="OXR42877"/>
        <property type="gene ID" value="B7C42_05215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="46011" checksum="2F9B5EF6F56678CE" modified="2017-10-25" version="1">MGFGRKLAGGDKGEINAELNQKAAEQIFSVLGELKGGAMKFGQALSVMEAAVPEEFGEHYREALTKLQAAAPPLPAAAVHRVLDQQLGTAWRKRFRSFDDAPTASASIGQVHKAEWSDGRTVAVKVQYPGADEALRADLKTLNRMAGMIGAVVPGADVKPILAEITERTEEELDYRTEAANQRRFAKAFDGHPRFLVPKVVAGAPKVIVTEWLDGTAVSKIIKRGQEDPAGTVELRNRVATLMGEFHFSSPALAGLLHADPHPGNFMMLDDGRLAVLDFGACAPLPDGFPPVLGQMVAMAVEDRFEELTDLMYSNGWVIPGRTVTHAEIADYLRPFTDPIREDSFHFTRKWMQRVAGRATDVSRPEMKTGMSLQLPAEHIMVFRVLMGSIGICAQLDAEVPFMKLMHDWVPGYAEYRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H264</accession>
    <name>A0A231H264_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tatC</name>
        <name evidence="7" type="ORF">B7C42_04803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42917">
        <property type="protein sequence ID" value="OXR42917"/>
        <property type="gene ID" value="B7C42_04803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="36149" checksum="380EA462EE502128" modified="2017-10-25" version="1">MRIPFDPRRSRRRTNPDGTMSLVEHLHELRSRLLKSLLAVALTTVLGFLWYSHSFLGIESLGDLLRGPYCSLPPEHRAQLTTDGACRLLATAPFEQFMLRFKVAFTAGVVMACPIWLYQLWAFVTPGLYAKERKYAISFVASGVVLFVTGAVLAYWVVAHALSFLMGIGSNVQITALSGSQYFGFIIKLLIIFGVSFETPLLIIGLNMVGVLTYERLKKWRRGMIFGLFVFAAIVTPQDPFSMLALAAALTVLFEVAVQIARLNDRRRARRGDNWGALSDDEASPLGGPDDLDGVSPVEPAQPVTASGPVSAEPAPKTPRPVSDYSDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H298</accession>
    <name>A0A231H298_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-dependent NADPH-azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azo1_1</name>
        <name evidence="2" type="ORF">B7C42_04852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778411.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42966">
        <property type="protein sequence ID" value="OXR42966"/>
        <property type="gene ID" value="B7C42_04852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="20926" checksum="20F0B03DBC07BF43" modified="2017-10-25" version="1">MTRIGIILGSTRPNRNGAQVAQWVLDSAARRGDAEFELIDLRDHPLPHLDEPVPPMFGPSVHAHTRAWAERIAQFDGFVLVTPEYNGGMPGVLKNALDHVFAEWVDKSVGFVSYGANGGARAVVQLRAVCSSLGMADVGYQVSISVLTDFENHTTFTPRDHHGAALDKTLDQVIAWSTALAPLRAGAETTLANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2W9</accession>
    <name>A0A231H2W9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-succinoylsemialdehyde-pyridine dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ald_5</name>
        <name evidence="5" type="ORF">B7C42_04623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.83" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43201">
        <property type="protein sequence ID" value="OXR43201"/>
        <property type="gene ID" value="B7C42_04623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="11"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="478" mass="51258" checksum="5C9EC2042E5040DB" modified="2017-10-25" version="1">MLIAGVLTDAASGARYDNIDPATEQVIGDTADAGAADVDRAIAAARTAFDDGVWATDREFRKHCLRQLHEALQDEKEAFRTELVAEAGSPVSITYMAQLDWPLADAIAYPAELIDDFEWERTLPDTELFGAVSHRRVVKEPIGVVAAIVPWNFPIEVALNKIGPALATGNTVVLKPAPDTPWGAARIGRLVAERTDIPAGVFNVVTTSDNGVAEQLLVDPRVDMVSFTGSIGVGKRIVELSAATLKRTFLELGGKNAMVVLDDADFGAVIPQSMIACMHAGQGCALPSRLLVPRSRYAEAVEIATATFGGIAYGDPTDPANFSGPLVNARQRDRVLDYIRKGESEGARITVGGGRPEHLSQGYYVQPTVFADVDNTMTIAREEIFGPVLAVIPFEDDRDAIRIANDSPYGLSGSVWGGDPERADAIARGIRTGTLMVNGGMFYGADSPYGGYKQSGLGRQNGREGFEQYLQTKVVGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3A4</accession>
    <name>A0A231H3A4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43307">
        <property type="protein sequence ID" value="OXR43307"/>
        <property type="gene ID" value="B7C42_04729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22782" checksum="7BF94F4490CB805D" modified="2017-10-25" version="1">MGRQATPLGRPRDPELDEKLMTAALLEYAELGWGAFTMQGVARRAGVGKSALYLRWANKEQLLLDSIESVALTLRVNMDTGSLTGDLTVLATALLEHFLDPIGWATLRITIDVTAEFTDLQPFQQRIVNSLRTFAARAFTRAVERGEMAADIAHEPLIESLFGAVLMHTLSRTQEGRAHARTYPAEHVAPLVEVIARSVRPAKSDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3J7</accession>
    <name>A0A231H3J7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyneurosporene desaturase</fullName>
            <ecNumber evidence="2">1.3.99.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crtD</name>
        <name evidence="2" type="ORF">B7C42_04287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.27" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43420">
        <property type="protein sequence ID" value="OXR43420"/>
        <property type="gene ID" value="B7C42_04287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="546" mass="57955" checksum="F390BEDDFC327843" modified="2017-10-25" version="1">MPVSSPTPGGSAPLDAEPVDAVIIGGGHNGLVSAALLADHGWDVVVLEAQDTAGGAVRSAELVPGYRMDLFSAFYPMAGASPALRGLGLEDHGLRWSRAPIVYGHPRSPEDTDAAVVHPDAEITAEALARRDARDGRTWMRLVEQWRQVREHLLGSFLGPFPPVRGAAGLWRDLGSADLFRYLRFLMLPVGRMVDEQFHDEAAKLLIMGNAMHADVPVDAPGSGVYGYLLTMLAQEGGFPVPVGGAGALSAALVHRAESAGARVHCGQPVERVVIRNGRADGVITAAGQMVRARKAVIADIDAPTLYTRLLADADLPQRLRADLERFTWDAPTVKVNYALSEPIPWRSKQLREAGTVHLGADRAGLARWTTDIGTGVVPHTPFMLFGQMTTADPSRSAPGTESAWAYTHLPRGVTDDAAADLLAERVDAVLEAHAPGFGSRIHARIVQRPSDLHSADGNLVGGAVNGGTSQLHQQLVFRPVPGLGRPETVVPGLYLGSASAHPGGGVHGTCGANAARAALADSRPTGWPRRKLLSRLHTALYDIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3L1</accession>
    <name>A0A231H3L1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator Mce2R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mce2R_2</name>
        <name evidence="5" type="ORF">B7C42_04307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779315.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43440">
        <property type="protein sequence ID" value="OXR43440"/>
        <property type="gene ID" value="B7C42_04307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="243" mass="26123" checksum="823A18EC212A7F7A" modified="2017-10-25" version="1">MAFQRIDRQTVPDAVFDQLVTEVLDGELPAGATLPAERQLAEALGVSRPTVREALRKLAHTGLIDVRQGGATTVRDFRRAAGLDLLPRLIVRNGEFDHTVVASILQARLVLGREVAALAAEQGGTQLHAELGDCLESLAAQQEPVAQQLEALKFWDHIVDGTGSIVFRLLFNTLREVYEPAIVALAGVMAAEVGSIDHYRRLTAAVVGGDPAAARTAADTLLRVAATQFDTVIRTMEGADDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3R3</accession>
    <name>A0A231H3R3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43376">
        <property type="protein sequence ID" value="OXR43376"/>
        <property type="gene ID" value="B7C42_04243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="53" mass="5919" checksum="C1D4188E6FC11882" modified="2017-10-25" version="1">MVSHDVIAQLRQDITTASDAGDEAEVQRLQRELDTALQAYRESGDDDAEREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H423</accession>
    <name>A0A231H423_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tpiA</name>
        <name evidence="5" type="ORF">B7C42_04472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43604">
        <property type="protein sequence ID" value="OXR43604"/>
        <property type="gene ID" value="B7C42_04472"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="27707" checksum="EE1126BC0FA8A736" modified="2017-10-25" version="1">MARKPLIAGNWKMNLNHLEAIALVQKIAFALPDKYFDKVDVTVLPPFTDIRSIQTLIEGDRLRITFGAQDVSVHESGAYTGEISAAMLAKLSCSYVVVGHSERRQYHNEDDATVLAKAKKVLQYDMTPIVCIGEGLGVREAQTHVQYNLEQLRGSLKGLTPEQIAKVVIAYEPVWAIGTGRVATPADAQEVCGALRAELVELAGQEVAAGVRILYGGSVNAKNVGELIAAADIDGALVGGASLKGDEFATLSAIAAGGPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4I3</accession>
    <name>A0A231H4I3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43702">
        <property type="protein sequence ID" value="OXR43702"/>
        <property type="gene ID" value="B7C42_03937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016273">
        <property type="entry name" value="Emycin_Estase_proteobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000880">
        <property type="entry name" value="Eryth_est"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="431" mass="46281" checksum="063875D8A83516AB" modified="2017-10-25" version="1">MPEPLTAVSLADWLRDHAAPLTHLDPDGPLDDLEPLRAIIGAARVVAIGENSHFITEFQQMRQRLLRFLVERCGFTVLAFEFGFSEGLLLDDWAQGAGTDDELAAQLAGTIPVGVGAPLRWIRRYNRTAATPVRFAGVDIPAAGGSLLPALGPVADYLREVDPETLPSVETAMRIAESFAGASAASAAPAWSRLPASDRDTLSAILARLLIRFRAVESLYVSRSDRRGYDIARHRLEAACHADYGFGAMADLFAGTGLTADTSARDSYMADTVLWHLRRCEPGSRIVLAAHNAHIQKEPVSFDGQNPAGFPMGHYLHRALGDDYFALGLTSTEGHTAEMLPDERAPLGFTVDATSLAPGAHGSVEAAFAEAGGGPGLADLRRARREISGPDARPDRTRLQSAYLHVPVLDAFDAMLDTRISTVADLDSGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4N1</accession>
    <name>A0A231H4N1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781209.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43752">
        <property type="protein sequence ID" value="OXR43752"/>
        <property type="gene ID" value="B7C42_03987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019639">
        <property type="entry name" value="DUF2505"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10698">
        <property type="entry name" value="DUF2505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="19403" checksum="687C69287E6CA642" modified="2017-10-25" version="1">MARRLDYSARYPLHTTEEVYAALSNRAYWDARMEEMRKHSPNEVVHLQADGDGIELELRHILPRDMLPEIAQTVMRKDLVITRKESYGPFGPEVEGEFSASVPAGPGTLTGTVRLFPTETGCTLRTSPVAKVFIPMLGPKLEQMMLVNLVDLFRAEAEFTQQWLEEQRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4N2</accession>
    <name>A0A231H4N2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781158.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43821">
        <property type="protein sequence ID" value="OXR43821"/>
        <property type="gene ID" value="B7C42_04056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025323">
        <property type="entry name" value="DUF4229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14012">
        <property type="entry name" value="DUF4229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="112" mass="12165" checksum="78C6FD9D384CC276" modified="2017-10-25" version="1">MSEASRSDDAASDRAPASAGRRLARNLALYTLARLALVAVIAAIILVVAHVVNVDIPLIVALLFALIVAMPLSLVLFKRLRARVNEDIAAVDEKRRNDKANLRARLRGEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5E0</accession>
    <name>A0A231H5E0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03621</name>
        <name evidence="1" type="ORF">B7C42_07978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000050">
        <property type="protein sequence ID" value="OXR39944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777254.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39944">
        <property type="protein sequence ID" value="OXR39944"/>
        <property type="gene ID" value="B7C42_07978"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44065">
        <property type="protein sequence ID" value="OXR44065"/>
        <property type="gene ID" value="B7C42_03621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="89" mass="9384" checksum="D5F81CDD927EA18A" modified="2017-10-25" version="1">MCRNITALRGLEPEATAEEIEAAALQYVRKVGGLSSISAATRPAVDEAVAEIAAATTRLLAALPDRKVPPKSVPPLRRPEVQARIAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Z0</accession>
    <name>A0A231H5Z0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44116">
        <property type="protein sequence ID" value="OXR44116"/>
        <property type="gene ID" value="B7C42_03673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="42487" checksum="B9CD5BDC22F6110C" modified="2017-10-25" version="1">MTPRGARSVVEPIVTAGAIVAGAGCAVALVNRLATRRLRAGATPVIEPVIIAIPARDEATRLPRLIADLRAQQGVSRMRIWILDDGSTDGTFPAAVEAIGDDDRFTVVAADTDPEPGWTGKTAACARLAELAGVTADPPPGALIFLDADVRLRPQAIAAAVSELRRSGAGSVSPWPYQRAGSLAEALVQPLLCWSWATTLPVRLADRSLRPSTAVACGQFLVFDAAVYRAVGGHAAVAGSITEDLALARTLRRAGHRTVLVAAGTLASTRMYRGAAEVDGGYTRWLWSAYGGTAGAVAVDTVAAVAYVLPALAALFGRGRIRRTGVTGYGLGVASRLLARSLESGTVPRGTDIGAALAHPVSIGAYLRLSGRSWLLHRRGALSWKGRPVPDGPGRSRPGRTELRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H659</accession>
    <name>A0A231H659_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44369">
        <property type="protein sequence ID" value="OXR44369"/>
        <property type="gene ID" value="B7C42_03157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20284" checksum="616715F10DA83F6B" modified="2017-10-25" version="1">MVRKLPAANCFPDAAAWAGWLDGHHTDDAGAWLLIARKGSSAPLITIDEAAEVALCYGWIDGHRRAHDDRSFLQRYSPRRPGSTWSQVNVARAEALIAAGRMRPPGLRAIEVARADGRWNAAYAPQRSAPVPPELAEALAADTATADRFAALDRTARYLLVLPLLKARTPTAKGRRLAEIMATLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6K0</accession>
    <name>A0A231H6K0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44653">
        <property type="protein sequence ID" value="OXR44653"/>
        <property type="gene ID" value="B7C42_03447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189489" evidence="1">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18263" checksum="7A4FD5C32644C948" modified="2017-10-25" version="1">MKFAGPRPVKGLVLALMAVAALTVTGCSMFSDAAKSDTARAKVGDCINVLEGSPADSKTEPVDCSSAKAVYTVKSTSDKKQDCGTEYSSYEETFNGGTTAFLCLAPNLKQGNCYHEDKTTGYSYAECDSAEATVKVVKRVDGQNDEFLCDANSTFLTLSEPKTTFCLANPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6R3</accession>
    <name>A0A231H6R3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">panC</name>
        <name evidence="7" type="ORF">B7C42_03205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44416">
        <property type="protein sequence ID" value="OXR44416"/>
        <property type="gene ID" value="B7C42_03205"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="169"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="36016" checksum="81BF12DC41DB2231" modified="2017-10-25" version="1">MSNSRAKKLTPEQLRTLYRPGELTVVHEPAALSAVTSALRGVGRTVALVPTMGALHEGHLELVRRAKRTNQVVVVSIFVNPLQFGENEDFDKYPRTLDSDVALLRDEGVALVFAPSVAQMYPEGPRTSVHPGPLGAELEGASRPTHFAGMLTVVAKLLQIVRPHEAFFGEKDYQQLTLIRQMVRDLNFDVEIVAVPTVRESDGLALSSRNRYLDEQQRESAITLSAALAAGRHAAGRGPDAVVAAARSVLDGATGVDVDYLELRGSDLGPIPSSGNARLLVAARVGATRLIDNLPVTVVPAVSDAASAGPSVVTQAAASGPVAPADGHNAVPDFQPAQADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6X7</accession>
    <name>A0A231H6X7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44674">
        <property type="protein sequence ID" value="OXR44674"/>
        <property type="gene ID" value="B7C42_03468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="29124" checksum="01C8B2F5BD2509BF" modified="2017-10-25" version="1">MSMAGRERPDSTGISAASAASGPTAVPQDEADGSTRPGSGGPGLRARLAKRLEGVGIMLRTGLLSDGARHELLLRGLPGKATILGVRPCRTSTFAVLPGDGTRKRTRAAGRIDAGYRFWVRIQLDGAPLYETRVRQRVSDADRESMQPGDVVGCRVDSGDRERLVLYVPGVTEATRVSISKILSAGRRADATVLAATPIAADYSGRDDPVLRLDLELRAWDEPQPWRVRIVQPVPLPAIELVDLGRHLEVAFFAVDRGESVAVDWEASAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H741</accession>
    <name>A0A231H741_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA</fullName>
            <ecNumber evidence="2">3.1.4.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cpdA_3</name>
        <name evidence="2" type="ORF">B7C42_03495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.53" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44701">
        <property type="protein sequence ID" value="OXR44701"/>
        <property type="gene ID" value="B7C42_03495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="27746" checksum="96FB8ED1497A6F9E" modified="2017-10-25" version="1">MILLAQLSDTHFDLDPRNAERVAAVLGYLDRLPRRPDAILVTGDLTESGTLAQYEQARKSLTTDIPLYVLPGNHDDRANLRQTLLDGPAEDGPINQAVEVGELTVALLDSTIPGSGGGELGERTYAWLDRLLAATPADASVLVAMHHPPVPMYSTVVDPIRLADPERLERTIAGDARILGVLTGHMHAMGTTLFGGRQLVVAPSVASAIGGAWEVEEPGDVPIDYAPDPSVVLHAVADRRLTSIVRTVPMGGRIRVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H788</accession>
    <name>A0A231H788_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44883">
        <property type="protein sequence ID" value="OXR44883"/>
        <property type="gene ID" value="B7C42_02838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15527" checksum="D2B2C51B379A16AA" modified="2017-10-25" version="1">MLAWLAFTVTFGGARLVTWLIHIDTSNVGDVSTGGTHLHHYLWGLVLLAGVAIFGMVDRSPRARTWMGLALGIALALIVDEAALLITLEDVYWHKDGWSSIAIALSLIGVVGTGLALTRNRIHHDAEDDEDDAEHRPAARRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H791</accession>
    <name>A0A231H791_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821213.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44718">
        <property type="protein sequence ID" value="OXR44718"/>
        <property type="gene ID" value="B7C42_03512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="278"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="45688" checksum="F51D6D0D46AB20B0" modified="2017-10-25" version="1">MDRREAAELARDWSAALVDCGGVPAALPRLPQLTEWIVDLEAAMSAEPFDPSPAYRVGVEMVRWKLTDPALMTPSATVLACLLERSQRPDRTQRFGALLGELGRGYSAELLKVHQDSQEIADQRFRVVFDNAAVAIALYDSNGITLEANPTTARMVGMKPEDVPGVAGLDLMHPEDRDKLQQVVVDLYQRRHGTVHFEGRFCRPDGTVCWGAWTMTLVRGAGGRDLRLLAVGEDITERRAMEQKLWWQARHDPLTGLPNRHCLLEQLEAIVATAGPADHIGLCFLDLDEFKLINDRYGHRAGDSVLAEVGRRLDATLTSPSVTVTRIGGDEFVALLAPPCDEKTAHAAAETMLATLREPVPVGPSDLLAMSASIGAVVAPVAGANAEKLLNDADVGLYRAKAAGRGTWVLHRDESGRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7D8</accession>
    <name>A0A231H7D8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lipA</name>
        <name evidence="9" type="ORF">B7C42_02709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44755">
        <property type="protein sequence ID" value="OXR44755"/>
        <property type="gene ID" value="B7C42_02709"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="93"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="362" mass="39927" checksum="9ABCF0F9130DEC30" modified="2017-10-25" version="1">MTSVDTPTSNSGTAHTAAPATSSSDSLVRESGGRKLLRIEARNAQTPIERKPKWIRTRATMGPEYSELKGLVKREGLHTVCQEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQIDTGKPAALDRDEPRRVAESVQAMGLRYSTITGVARDDLEDGGAWLYAETVRAIKRLNPHTGVELLIPDFNAEPDQLAEVFSARPEVLAHNVETVPRIFKRIRPAFRYERSLAVLTAAREAGLVTKSNLILGMGETPEEVTQAMRDLHEAGCDILTITQYLRPSPRHHPVDRWVKPEEFVEHSRVATELGFAGVMAGPLVRSSYRAGRLYAQAMAHHGREIAPEMAHLAEEGSASQEASSVLARFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Z5</accession>
    <name>A0A231H7Z5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrimidine/purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
            <ecNumber evidence="3">2.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Adenosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cytidine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Guanosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Inosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thymidine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Uridine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Xanthosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppnP</name>
        <name evidence="4" type="ORF">B7C42_02922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine</text>
            <dbReference type="Rhea" id="RHEA:52540"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:27638"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:18107"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoside phosphorylase PpnP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EC" id="2.4.2.2" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44965">
        <property type="protein sequence ID" value="OXR44965"/>
        <property type="gene ID" value="B7C42_02922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047975">
        <property type="term" value="F:guanosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01537">
        <property type="entry name" value="Nucleos_phosphorylase_PpnP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009664">
        <property type="entry name" value="Ppnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36540">
        <property type="entry name" value="PTHR36540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06865">
        <property type="entry name" value="Ppnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11058" checksum="99E85F7541EFA13C" modified="2017-10-25" version="1">MSQFENVSVATKANVYFDGTCVSYSLTLPDGTKKSVGVIQPATLTFSTGAPEVMELVEGECAVTLPDETEPTTYRGGESFSVPGHSSFDIEVVQTLHYVCHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H855</accession>
    <name>A0A231H855_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid-associated protein EspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">espR_2</name>
        <name evidence="2" type="ORF">B7C42_02937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043806.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44980">
        <property type="protein sequence ID" value="OXR44980"/>
        <property type="gene ID" value="B7C42_02937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="16712" checksum="93CAA82544192E86" modified="2017-10-25" version="1">MNEDPTTTPRADGEPTELAAKINRLLAVMHPPSEPPLSNVAAAEAITKATGTSISAAYLWQLRSGVKSNPTVAHLRAIAKFFGVPASYLLDNGTDAALDSQLSLLQAMKDAGVRNLALRASGLTPRTLSSIASIVDRARELENLPPVDGDEREDQDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8D6</accession>
    <name>A0A231H8D6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">B7C42_02408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45283">
        <property type="protein sequence ID" value="OXR45283"/>
        <property type="gene ID" value="B7C42_02408"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="256"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="412"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="499" mass="54041" checksum="051023017DFE8F3C" modified="2017-10-25" version="1">MRRFVAAIDQGTTSSRCIVFDRSGRIAGLGQREHEQLFPRPGWVEHDAETIWRNTEFVIGAALEDAGIGAGDIAAVGVTNQRETTVVWDRATGKPVANAIVWQDTRTAALCDELAGDVGPARYADRTGLPLSTYFAGPKLRWILDNVDGVRARAEAGDLCFGTMDSWILWKLTGRHLTDVTNASRTMLMNLETLQWDSQICAEFGIPVSMLPQIHSSSEVYAEISDGPLAGVPVAGILGDQQAATFGQACLSPGEAKNTYGTGNFMLLNTGTTPVFSKHGLLTTVCYRLGDQPAVYALEGSIAVTGSLVQWLRDNLGIVESAAEIEPLARSVDDNGGTYIVPAFSGLFAPRWRPDARGVITGLTRFVTKAHLARAVLEATAFQTREVIDAMRADAEAENLGVELTTLKVDGGMVANELLMQFQADILDVPVVRPVITETTALGAAYAAGLAVGYWSGTDDIRANWSEDKVWQPTMSEADRDHLYGEWNKAVERTYGWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8J5</accession>
    <name>A0A231H8J5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_03003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45046">
        <property type="protein sequence ID" value="OXR45046"/>
        <property type="gene ID" value="B7C42_03003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="222"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="286"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="533" mass="56314" checksum="110849C376646D65" modified="2017-10-25" version="1">MSTDLFFAAPARPDVPDDGHAATSPETGLYHVGAEPDCASAGEKRATETSAGETSAVDASGYHAAVADSSSADTSVRSAAAAETAVAEQHSDHVSLRDLIDDRRVDAALTWLDDNAPHRIADELARMDAVHAGIAFRLLDKDRALAVFEELEPVDQQQILSGMRDQSFRELVEGMDPDDQARMLREAPATVAKKVLAGLSPRERRMTAALLGYPEGSVGRYMTPEVVALHCDLTVDQALRVVRAKGAHAETVYTLPVVDGGRRLTGVVEMRELVLSDPGTMLTELVVTAPVFARAMDAAEKAARLMRETNLINLPVVDSEDRLVGLLTIDDAVEVIEAADSEDVARQAGASPWSGHYMAAGVFQLARYRAMWLLLLLVAATLTVTVTDAFEATLAQAAHLALFIPLLIGAGGNAGAQAATSCVRALAVGEVRVSDLLKVIWRECRVGLVLGSMLAVVGMVIGAAFVGAQIALVVGITLVIICGWAATIGGTMPLLAKKLRIDPAVISAPMVTTLVDATGLIIYFTTAKLVLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8R3</accession>
    <name>A0A231H8R3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45116">
        <property type="protein sequence ID" value="OXR45116"/>
        <property type="gene ID" value="B7C42_03073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127246" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="38859" checksum="475AC7D8C856B6FC" modified="2017-10-25" version="1">MKLRALAQLAAVCLVASAGSGCSLLPGSLGTATNEVLGDNMRISADFDNVAGLYAGNEVDVLGVPVGTVESVEAEGTYVQVVMKVDKSVKLPADAMAALVNPQLITNRHVELAPAYDGTGPTMADGAHIPLPRTRTPVELDRIMQTFDQLGASLKGDSDTGPMASRVLFPLLNGNGDKLRETLDALSGAFETTFANKDQISDTIVKLNDVTQVIAQNDQTVRDFSGRLTELLKLMGDQAPGLQAVLTQLNDFVANTATVVGQNKDQLAGALTRFVAISDQMRANARNLTEIVDVAPLMFENLANATSYEHQALRLHGLLDKSVLDGEALSTFCERVMMRLDGCRTGKIADMGPDFGLTAALLGISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H958</accession>
    <name>A0A231H958_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rplW</name>
        <name evidence="6" type="ORF">B7C42_02678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025347175.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45553">
        <property type="protein sequence ID" value="OXR45553"/>
        <property type="gene ID" value="B7C42_02678"/>
    </dbReference>
    <dbReference type="GeneID" id="66718913"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="11082" checksum="6BF41B04BE4F3137" modified="2017-10-25" version="1">MTTIADPRDILLAPVISEKSYGLIEEGTYTFLVHPDSNKTQIKIAVEKVFGVTVTSVNTANRQGKRKRTRFGYGQRKSTKRALVTISADSKPIEIFGGPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAB3</accession>
    <name>A0A231HAB3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cholesterol oxidase</fullName>
            <ecNumber evidence="5">1.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">choA_2</name>
        <name evidence="5" type="ORF">B7C42_02186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45894">
        <property type="protein sequence ID" value="OXR45894"/>
        <property type="gene ID" value="B7C42_02186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012014214" evidence="2">
        <location>
            <begin position="29"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="3">
        <location>
            <begin position="239"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="4">
        <location>
            <begin position="461"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="532" mass="56007" checksum="CF4D99305E2902F4" modified="2017-10-25" version="1">MTPMKRRSFLLGATAAGLTLATAATASAQPWMTTGRRQTSVPLTREDHRVVIIGSGFGGGVSALRLAEAGVDVLVLERGMRWPTGPDADTFPHPSRPDRRMLWYRSAPEVLGVPVALEPYTGLLEAVVGENMTAVCAAGVGGGSLVYQGMTLQPTEATFSEVFPAELDYALMAREHYPRVARMLGTGVAPDELIDSPTYLPSRAFARNVGAAGYELSKIPMPIDWSFALREVRGEMKPSYINGDCALGVNNGGKHSVDVTYLARAEATGRATVRTQHEVTDVARTPDGRWQISVDRIDTAGRVVEHLVLTSNALIMAAGSINTTKLLLRAAAKGQIADLPDGLGGQWGNNGDRIFTWTSATDDFGTAQGGPVVYGSKEWDDPAIANTVIQASIPPAGVDAHSTMLVGFGITDGRGHLAYDAATDDAKLYWPADADAALQQRIAARVHAIAGPGSTVFDTNAAAPSTWHPLGGAPMGTVCDLEGRVHGTRGLYVLDGALIPGSTAACNPSMTIAAVAERALDRIVATDIGTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAS5</accession>
    <name>A0A231HAS5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
            <ecNumber evidence="3">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45827">
        <property type="protein sequence ID" value="OXR45827"/>
        <property type="gene ID" value="B7C42_02119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="27725" checksum="E564B9912A71FEA9" modified="2017-10-25" version="1">MRIGFVGAGRMGLPMVRRLAAAGHDVRVAVRRDDVRTAVTEAGARAVDTAAAAAEGAYAVLVCVFSDDQVREVCLDGDLPAAMAPGSILALHTTGDPRTAVAVAAQAVPHAVRVADAPVSGGPHDIAAGALTVFVGADEDTAADLRPVLSCYADPILRVGALGAGQRVKLVNNALFAAQAGLVAAAVRLAGQLGVTEAALLSALPHASSSGRVVTSIAAKRSVAEFGGAVGEFLRKDVAVVRTLTTELGGTLGVLDAAISAAPFGRDGNAAPQGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAU3</accession>
    <name>A0A231HAU3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aliphatic sulfonates transport permease protein SsuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssuC_2</name>
        <name evidence="6" type="ORF">B7C42_02248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777652.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45955">
        <property type="protein sequence ID" value="OXR45955"/>
        <property type="gene ID" value="B7C42_02248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="102"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="31725" checksum="1F4D6D7F9266BC6F" modified="2017-10-25" version="1">MSTTLPATAEPVLVSKKSSVPAGSAAEAPARSTAGTGRQLAALAGRWGWRLFKPVLVIGLFLTFWELAPRFGLVDQIFLPPFSTVVQRGDELIRNGQLWDNTSASLGRSLVGFAIAVACAVPAGVAIAWYKPVADFVNPLLELFRNTAALALLPVFILILGIGETSKVAIVVYAGFFPILLNTISGVRSVDPLLIKSAVSLGFSPLRLFQKVILPAAVPTIFTGIRMAASASILVLIATEMAGARAGLGYLITAAQQNFQIPDMYVGIVAIAIVGLVYNAVLVAIERRLTRWRPQSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAU5</accession>
    <name>A0A231HAU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Soluble epoxide hydrolase</fullName>
            <ecNumber evidence="5">3.3.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45847">
        <property type="protein sequence ID" value="OXR45847"/>
        <property type="gene ID" value="B7C42_02139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="44262" checksum="7A9B6F759BE65A56" modified="2017-10-25" version="1">MSALGHLDPMSTPDSIDVQPFEAHATDADLDDLRARLAVARLPEAETVSGSPRWAQGVPLADLVDLVNYWGTEYNWRSFEERLHRIGQYRTTIDGLGIHFLHRRSARADATPLILTHGWPGSIAEFIDVVDELADPEDAAAPAFHVVVPSLPGFGYSDKPATAGWGTEKIAAAWVELMERLGYRKFLAHGGDWGGNITTVLGGRFPEHVLGIHSLFAEAPPGMTTDGLTATERQWAEETRHFWRHRAAYAKQQATRPQTIGYSLVDSPVGLLAWILDKFAEWSDTEDSPFETISKDRILDDVTLYWLTRTGASAARIYYESHNSLDPDLRVDVPSAITMYPHDIEKSPRPWAEKRYRRIVRWNAPESGGHFPSLEVPDYFVNDLREGLAAVLAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB31</accession>
    <name>A0A231HB31_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_01021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46058">
        <property type="protein sequence ID" value="OXR46058"/>
        <property type="gene ID" value="B7C42_01021"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="121"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="42865" checksum="70AFD865DE57DB56" modified="2017-10-25" version="1">MDLVGARAEFGAGVTATVRLTVADDDPFGPDNLPYGVFAPPGGPFRAGVRFGAQVLDIAALLDDSIFARPTLNGFLAQGPARWHTVRERLRDAVRAPLPAAAIHPLESVRLSLPISIGDYVDFYASIDHATRLGGYLRPNGEPLLPNWRHLPVGYHGRAGSVVVSGTPVRRPCGQRRTASGAPEFAPSTRLDIEAELGFVVGVGSEIGTSIAVDDFAGHVFGVALVDDWSARDIQAWEGQPLGPFLGKSFATSLAAWITPLAALESARIAVPEQRPEPLSYLRGHQDWGFDIDVRVHWNGVPVSAPPYRAMYWSAAQMLAHLTVNGAGTRPGDLFASGTISGPRQDQSGSFIELSGNGAHPVDVGGCERTFLADGDTVLLTATAPGPGGARIALGEVGGRILPANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB51</accession>
    <name>A0A231HB51_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein YxlF</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yxlF</name>
        <name evidence="5" type="ORF">B7C42_01045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781376.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46081">
        <property type="protein sequence ID" value="OXR46081"/>
        <property type="gene ID" value="B7C42_01045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="34120" checksum="919E9FAA81242DCD" modified="2017-10-25" version="1">MIECRGLTKRFGATVAVENLSFTVTPGKVTGFLGPNGAGKSTTMRMILGLDQPTAGTAVIQGKRYRELDHPLRAVGALLDAKWVHPNRSARSHLRWMAAANDIPAGRVEEVLRLVGLTEVADKKAGGFSLGMSQRLGLAGALLGDPPVLLFDEPVNGLDPEGILWIRRFMQRLAAEGRTVLVSSHLLSEMAQTADHLVVIGRGRLIADTDTKDFIAKSSESTVRVRSPQLDELRSLLTSNGMTVREDGSAADREGPADTAPALVVIGETSDAIGKLAGANSITLYELAPQQASLEEAFMRMTGGAVQYHGEGVEQAMGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB71</accession>
    <name>A0A231HB71_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">thiE</name>
        <name evidence="13" type="ORF">B7C42_01049</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46085">
        <property type="protein sequence ID" value="OXR46085"/>
        <property type="gene ID" value="B7C42_01049"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="12">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR46085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="23788" checksum="A1674707F5F324D4" modified="2017-10-25" version="1">MAPRERLASARLYLCTDARRDTGDLAAFAEAALSGGVDIIQLRDKGSAGEAKFGPLEAGAELGALAELKAAARRHGALVAVNDRADIALAAGADVLHLGQGDLPPWYARRIVGPDVVIGRSTHNRNQAGLAVVDEHIDYFCTGPVWNTPTKPGRTAAGIELVRSTAESHPTRPWFAIGGIDRDRLPEVLAAGADRVVVVRAITAARDPQAAARELKQRLLENAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBC7</accession>
    <name>A0A231HBC7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46119">
        <property type="protein sequence ID" value="OXR46119"/>
        <property type="gene ID" value="B7C42_01084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012940680" description="DUF4185 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="3">
        <location>
            <begin position="176"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="495" mass="52886" checksum="AAE76ABCEFF435E0" modified="2017-10-25" version="1">MRVRVPASVAVMLLGAGLLVGLPGSAGAEPGTGSAATVPGAGPCATDPAPVHEPVVPKKLEVPIPYPVVTVDQAPPPAVPKRTNVDLPADPCVSPCPDLTDGPPSPPGLLNRLGLPEVLLKPKPFYFALPPGPSPEPAPPVPPRATPPTEPGPVVAARPAPKVSRVREVAKETGANSVNRTDKRWQVAGTDLGIMWESGPGEIATAFGDTVGHDFHPPGGMGEDWRSNLLAFSTNRDLDKGMIIDRMVADDRCHAAEVLASRKKDNIEITTIPTSGFALPHRGSADGTRQFMSYMSIRTWNSLPGTFYTNYGGIAYSDDHGQTWTKDPHAHWDNIFGLANFQVSAMVPQGDYVYLFGTPNTRLGAVGLARVPKDEVLDTSAYQYWRDGNWTPVGGAASATPIVDGPVGELSVRYDSARGVWQMSYLDTAKAAVVVRESNAPQGVWSPSSPLVPVSAEYPELYGGFIHPWSTSSDLYFTISTWSDYNVYLMHARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBM1</accession>
    <name>A0A231HBM1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional activator HxlR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hxlR</name>
        <name evidence="2" type="ORF">B7C42_01246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781579.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46280">
        <property type="protein sequence ID" value="OXR46280"/>
        <property type="gene ID" value="B7C42_01246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12824" checksum="35C2A1088EC90340" modified="2017-10-25" version="1">MANECDTQHSVCGMSVAIDVVGGKWKLHLMWVLGEGPQRFGRIRALLPGVSEKVLTENLRHLESHGVVRREVFPEIPPRVEYSLTPAGVELAAALRPLEQWGERRRDGLFDPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBN5</accession>
    <name>A0A231HBN5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781596.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46300">
        <property type="protein sequence ID" value="OXR46300"/>
        <property type="gene ID" value="B7C42_01266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="14238" checksum="54B0E65727B3E05A" modified="2017-10-25" version="1">MPVSGRFQPNPPPAVGTRSRVLLRFRCAGRDFLLRQTIIEPGGDSGWHYHDGTLFVLVTGSTLHHPGTDCVPVTYRPGRIFREPAGAAHAHTARNRTRKPLRLTVFYVLPAGSPLSRSIGAPECDTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBQ3</accession>
    <name>A0A231HBQ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA_1</name>
        <name evidence="6" type="ORF">B7C42_01339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781719.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46373">
        <property type="protein sequence ID" value="OXR46373"/>
        <property type="gene ID" value="B7C42_01339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="512"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="671" mass="73225" checksum="EF1B81375A8011B5" modified="2017-10-25" version="1">MPEVERHKYDVVVIGAGGAGLRAVIEARERGLSVAVVCKSLFGKAHTVMAEGGCAASMGNANEKDNWQTHFRDTMRGGKFLNNWRMAELHAQEAPERVWELETYGALFDRTPDGRISQRNFGGHTYPRLAHVGDRTGLEIIRTMQQKIVSLQQEDYAATGDYEARIKVFAECTITDLLKDTSGIGQRPEEAAGVTTEGARSRSNDTGAISGAFGYWRESGRFVLFETPAVVLATGGVGKSYKVTSNSWEYTGDGHALALRAGASLINMEFLQFHPTGMVWPPSVKGILVTEGVRGDGGVLKNTEGKRFMFEYIPAVFKGQYAETEDEADQWLRDNDSARRTPDLLPRDEVARAINEEVKAGRGTEHGGVYLDIASRLPAAEIMRRLPSMHHQFKELADVDITKEPMEVGPTCHYVMGGIEVDPDTGAATVPGLFAAGECSGGMHGSNRLGGNSLSDLLVFGRRAGLGAATYVEQLAQRPAVADADIDAAAKSALAPFDPPATGTGENPYTLHTDLQQTMNDLVGIIRKEHELEQAIGRLGELRERYDSVTVEGHRQFNPGWHLALDLRNMLLVSECVAQAALLRTESRGGHTRDDHPQMDPQWRNRLLVCRTDPDGVGQTVPPVTVTSEDQKPMRPDLLALFELSELEKYYTPAETAAHPAAAESSAKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBQ9</accession>
    <name>A0A231HBQ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46252">
        <property type="protein sequence ID" value="OXR46252"/>
        <property type="gene ID" value="B7C42_01218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11650" checksum="28649785DE170D18" modified="2017-10-25" version="1">MLTTSGSAPDPIHETYLRVQDYVRQHPEYASFFDPQPDGYYHGPNMLRDWSEVADGSGATLNEWRDDYSRFAAAVNRQLGREEFPPRAADSPIFEPTTATAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCH0</accession>
    <name>A0A231HCH0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036496921.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46466">
        <property type="protein sequence ID" value="OXR46466"/>
        <property type="gene ID" value="B7C42_01435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="14652" checksum="799D304FC3D19D7C" modified="2017-10-25" version="1">MTTTPQEHPVRQGIAAGTSIGAAILLVTVGVLSILEGISAVANDNLFVVGIDYVYQFDTTTWGWIHIVLGILLVIAALGLMAGTTWGRIVAITLAALSILANFLWLPYYPAWSILVIALNVVVIWAVATWQPGPDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCI7</accession>
    <name>A0A231HCI7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46377">
        <property type="protein sequence ID" value="OXR46377"/>
        <property type="gene ID" value="B7C42_01343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="8978" checksum="8A05B9468FE56D24" modified="2017-10-25" version="1">MTAFAGGGARHAAHRHARHRVGGGYRAAARLPETRPLPVGGAHRPRHARRSGPDLYDRIVLAIAGWLLAIRIAFVGEQVIDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD93</accession>
    <name>A0A231HD93_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46735">
        <property type="protein sequence ID" value="OXR46735"/>
        <property type="gene ID" value="B7C42_01712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13646" checksum="9388D7BC43EE537D" modified="2017-10-25" version="1">MGVARIPDDLDLPPGETLDYAQRLLDEGLAFNAHEVLEAAWKNGPFAERMLWQGLAQYAVGLTHIQRGNPKGARTLLERAIGRLSATPAPPYGIDVAGLVAHAEGLLADLDAGREIPEDALCPRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDC7</accession>
    <name>A0A231HDC7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase MhqP</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mhqP_1</name>
        <name evidence="6" type="ORF">B7C42_00045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46930">
        <property type="protein sequence ID" value="OXR46930"/>
        <property type="gene ID" value="B7C42_00045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="16559" checksum="B041A900353376F5" modified="2017-10-25" version="1">MDGTELARVMLRTVVGATMIAHGVKHGRSLEGTAGWFESIGFTQPRAQARASAVVEAGAGAAIIAGAGTPLAASAVVATMAIAARTVHAANGFFITAEGYEYVLNLATASVVISALGSGRWSVDGLVRGGSRGSGARRAALAAGLGLAAASVQLAVFWRRPSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDE9</accession>
    <name>A0A231HDE9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl-CoA hydratase echA8</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">echA8_1</name>
        <name evidence="2" type="ORF">B7C42_00013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782683.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46899">
        <property type="protein sequence ID" value="OXR46899"/>
        <property type="gene ID" value="B7C42_00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="38112" checksum="C8588DCEE4A458BC" modified="2017-10-25" version="1">MTDDAHHSGTRPAAWREDLTSGEDSLFADRPEPEQGPAYRTLTYEVTGRIARITFDRPEHGNAITADTPIELAHAVERADLDPRVHVMVVSGRGKGFCGGYDLSIFAENGLSPTVSAQPTTGTVLDPVVQARNHNPWGTWDPMVDYQMMSRFNRGFSSLLHANKPTVAKLHGFAVAGGTDIALFCDQIICADDTKIGYPPTRVWGIPAAGMWAHRLGDQRAKRLLFTGDCLSGKQAEEWGLAVESCPADELDERTEQLLERISRMPINQLIMAKLALNSSLLAQGVANSGMVSTVFDGVSRHTREGYAFQLRSATVGFREAVRERDEPFGDWKRAQFDRPDGAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI2</accession>
    <name>A0A231HDI2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46981">
        <property type="protein sequence ID" value="OXR46981"/>
        <property type="gene ID" value="B7C42_00097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16480" checksum="564E411784585BA0" modified="2017-10-25" version="1">MGDLEDNVVEHPNALVVRRLMAALSEQNRAEIEAVLADECVWRVPGANALSGVYEGRRSILTLFGKMKRIFTGPAKFEVIDITASDGYAAAYQYGIVEVADRTVRLRECLVYRVVDGRVTEVDEFQADMEAFDDAFSAESVAAAQAGKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDM4</accession>
    <name>A0A231HDM4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47021">
        <property type="protein sequence ID" value="OXR47021"/>
        <property type="gene ID" value="B7C42_00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29348" checksum="9016175E35DC4A89" modified="2017-10-25" version="1">MAELAPYGSRLTPYVAVLRSRMRSQRAYPLSFATDLFSSLLIGVVEFAEMWLIYHNVTALGGLNSTQMLLLFGLSNLSFALAQIAVGHTDTLATYIRMGTLDAFHLRPQPLLLQLITSDVSLRRLSRATVAAVVLIAGLIGNDIDWSPTHIVLAVSSTLSGIAIFAGLFVCAAGLQFHLVDGSELTNSFTYGGSFAAQQPSSVFSGPLRALFGFAIPVSFVAYLPTIALLGLPGPPWLPAWLAWFGPLAALWVWIIAATLWRIGVRHYQGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDP0</accession>
    <name>A0A231HDP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46837">
        <property type="protein sequence ID" value="OXR46837"/>
        <property type="gene ID" value="B7C42_01815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="489" mass="54253" checksum="ABDB18377117399E" modified="2017-10-25" version="1">MAIAKPSDMFDRTREWEALTRFVTSGQPHATLGVVSGRRRQGKSFLLEALCEATGGFYFAADQATEAESLRYFSGAVADYSGSDLPVTFEDWRQAVDGLLAVTVDREVPVVIDEFPYLAKAAPALPSIVQAALAPRRPERLRSRGRLLLCGSALSFMGSLLSGDAPLRGRAGLELVVPTLDYRLAAEFWGIEDPRLAVRVHAIVGGTPAYRREFVEDDAPSGPEDFDDWVRRTVLNPSSPLFREARYLLSEEPGLRDPGLYHSVLSAVAHGNSTSGGIASYVGRKASDIAHPLAVLEDCGLLRREPDLFRGNRILYRISEPLVTFYQTILRPEWAQWERGRDTDRLWRRRRSRFDSNVLGPHFEQICRDWIAGYAPPETFGGYPGRVGSGVVNDPADRATHEVDVVVFGEGREGTESLLAIGEAKWNDVVGTGHLDRLRRIRQLLSNRYDTSETRLICYSAAGFMPALEREAARASDIALVGLDDLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDQ7</accession>
    <name>A0A231HDQ7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">clpP_1</name>
        <name evidence="2" type="synonym">clpP</name>
        <name evidence="4" type="ORF">B7C42_00191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777002.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47071">
        <property type="protein sequence ID" value="OXR47071"/>
        <property type="gene ID" value="B7C42_00191"/>
    </dbReference>
    <dbReference type="GeneID" id="66721033"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="20992" checksum="C4733266C622A157" modified="2017-10-25" version="1">MTSYTIPNVIAQHPRGERIMDVYSHLLTERIVYLGTPIDSGVANALIAQMLHLDAESAGQEINLYINCEGGDLSAMLAIYDTMQHISSPVATTCVGQAIAVGAVLLAGGAAGRRAMLPHARAVLHQPATRGQGAIPDLIIQADELVRMRAEIETILSRHTGQDVATLRHDTDRDRVFTAQAAVEYGLADTILGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDZ4</accession>
    <name>A0A231HDZ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46996">
        <property type="protein sequence ID" value="OXR46996"/>
        <property type="gene ID" value="B7C42_00112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12511" checksum="08DF72279074B426" modified="2017-10-25" version="1">MPGVEDGIAANHSPVCVAVHELNFPTVEHLPPGDVRDIDLARLPATELFWASPACPAWTDAKGEKRYFDRSNQYTMFDEELGVIEDHAAGRWSSRSRGTCGRWPDAGSRCWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE16</accession>
    <name>A0A231HE16_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47181">
        <property type="protein sequence ID" value="OXR47181"/>
        <property type="gene ID" value="B7C42_00303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="34615" checksum="870819E1F0798A21" modified="2017-10-25" version="1">MLSGSTPVARIARFTVARYETHHLLYAVMFVAAVEGTAAVVSHPDSAWRPGWATALRIVVVAVLLLYLRMVDEIKDLDYDRVHNPDRPLVTGAVSVGELWGAIGSLAVTLAVMSALLSWWSAVLVVAAMGYGLALWGLESISARIRADLLLNLVVTYPVQLWIMAYLVRSAIDTGQVESGWRTAWVALIFAGAFLHFEFARKTAADARPGQWYYSNVLGVRGSVVAIVGCAALAVGADVALTRPWDHPLPWASPTWIPVGLLLLPVLVAGSFLARAPDPMRPPVPPSESDSATRAYPVIPAVVFVLVLYLILIATAVTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE60</accession>
    <name>A0A231HE60_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">General stress protein 39</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ydaD_1</name>
        <name evidence="1" type="ORF">B7C42_00154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47035">
        <property type="protein sequence ID" value="OXR47035"/>
        <property type="gene ID" value="B7C42_00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="29672" checksum="F1CFD72777274975" modified="2017-10-25" version="1">MVERPGRVDGKVAIVTGAGSTPGPGIGTGKATAVALAREGAAVLLVDRYGERAEQTLRMIEEEGGKAAVFAADLTEAAACEAMVRTAVDSFGGLDILVNNIGLAAVGTVVDVSEADWDRSFDINLRTAFLASKYAVPALAERGGGSIVNISSISALRGDGTVAYSAAKGGLLAMTVDMAYSHGRQGIRVNAIAPGHITTPMVLSVSAPGPRAEFMNAMRSEAGLLGSPGDGWDVAWAATFLASDEARWITGITLPVESGVLSVTPLMMAPHLRAVPEPAPAEPPAPESAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEH5</accession>
    <name>A0A231HEH5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator AcrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acrR_1</name>
        <name evidence="6" type="ORF">B7C42_00474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782087.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47351">
        <property type="protein sequence ID" value="OXR47351"/>
        <property type="gene ID" value="B7C42_00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="211" mass="23655" checksum="17EC79D396DAAA19" modified="2017-10-25" version="1">MPSKAVGQRRRPTQERAKETRQHILDTAARLFGERGIENTSTNRIAAEAGLSIGTVYRYFSDRTVIVEELLERLLESIERRFTERLDRAERSVEDMTADILAAICDELVDNAKLVRALAAGVQFYNSGIPEFEPRLRLLVKVLLIQILGPSDDHELDVMAFVLVNTGFSAVLRASALEVDPEERREAIVMTARMIGAWSTAEIERRAANSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HER6</accession>
    <name>A0A231HER6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">leuD</name>
        <name evidence="12" type="ORF">B7C42_00578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503809.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47453">
        <property type="protein sequence ID" value="OXR47453"/>
        <property type="gene ID" value="B7C42_00578"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="22382" checksum="079696FC3D108932" modified="2017-10-25" version="1">MEPFKVHKGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRSDPGFILNTSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFADIFRGNAGKGGLVAAQMSQHDVELLWKLIEEHPGLELIVDLEARTVAAGTTVLPFDIDDYTRWRLLEGLDDIGLTLRQEEAIEQFEKARPSWKPTTIPAAISGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFG6</accession>
    <name>A0A231HFG6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779772.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47558">
        <property type="protein sequence ID" value="OXR47558"/>
        <property type="gene ID" value="B7C42_00683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011267698" evidence="1">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="17368" checksum="D406E06BD709AA1D" modified="2017-10-25" version="1">MRALIVTAVVLAWTVAVTLCTAPSARAGDIETSCAGTSTVTYTPGLTATARPTTIVTDATLSCTSSDASITGGTTHAGGRAEIGCGPAAGVGTSRIEWNNGRHSTFRFRTVFADRPAGQTVIVVSGTVVDGEFLGDQVDGAGVYLTPDLAGCATATGVTSTTGPLVRTFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFK2</accession>
    <name>A0A231HFK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47487">
        <property type="protein sequence ID" value="OXR47487"/>
        <property type="gene ID" value="B7C42_00612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18342" checksum="02F140E4B1FFC141" modified="2017-10-25" version="1">MSEQTANSAAPTAAASAQPATVAAAPQTKAPKPVTELWVERTGTRRYTGRSSRGAEVLIGSDGVEGVFTPGELLKIALAACTGMSSDFPLSNRLGENYDTTIRVSGDADRENEVYPELKEVVELDLSELDEAGRQRLLVTVQRAIDKVCTVGRTLKAGTTVNLTFQIDKIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFK4</accession>
    <name>A0A231HFK4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative zinc protease</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_00787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47662">
        <property type="protein sequence ID" value="OXR47662"/>
        <property type="gene ID" value="B7C42_00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="83"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="237"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="497" mass="53676" checksum="BE014CE062B5AB11" modified="2017-10-25" version="1">MDVTKKKSSARAAKPSVSTRAPGSTARAPKTKQASRARTPAKTPSADAPLLALEQGGSSLVLAEDGSFSDTGVRRTVLPGGLRVVTEHVPGVRSASIGVWVGVGSRDEGPSVAGAAHFLEHLLFKATPTRTALDIAEAVDAVGGELNAFTAKEQTCYYAHVLDDDLPLAVDVVSDVVLNGLCRPIDVDVERQVVLEEISMRDDDPEDLVGDSFLTALFGDHPIGRPVIGTVDSIEQMTAAQLRGFHLRRYRPDRMVVAVAGNIEHEHTVELVHRAFADRLDPLREPAPRREGHFRKRTSPQLQWTYRDSEQAHLVFGVRAFGRHEGHKRWPLSVLNTVLGGGLSSRLFQKIREERGLAYSVYSSVDTFADTGAFSVYLGCQPENLAEVTTLAREVLEEVAANGITDAECARAKGSLRGGLVLGLEDSGSRMNRIGRSELSYGNHRSVSETLARIDAVTTAEVSAIARTLLARPYAASVAGPYRRARDLPGAVKRLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFL0</accession>
    <name>A0A231HFL0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47465">
        <property type="protein sequence ID" value="OXR47465"/>
        <property type="gene ID" value="B7C42_00590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="20923" checksum="5074407764E35C60" modified="2017-10-25" version="1">MVSPHRPRIAAATPEYARDLAICHIESWREAYRGLVPEHMLAAFDVDRRAARWAALIDSIGESTAADRTAHTIVLAIDDTRAPGDRVLGFAHAGPPRDEPRVADRELYALYVRADRYGTGIAQELLRAILLPDTDTALWVFEENPRARNFYRKFGFAADEARRIEPFSLASEIRMIARRPITGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFX9</accession>
    <name>A0A231HFX9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS-type transporter EfpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efpA_1</name>
        <name evidence="7" type="ORF">B7C42_00751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47626">
        <property type="protein sequence ID" value="OXR47626"/>
        <property type="gene ID" value="B7C42_00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="486" mass="50126" checksum="69EAA836DE59A9BD" modified="2017-10-25" version="1">MQYPVTKRAFGLPILVLSGLQLMVVLDGTVVILALPALQRHLGLTSSGSAWTVTAYGLTYGGLMLLGGRLGDSLGRKKMLLLGVSFFTLASLLCGLAQNEAMLIGARALQGTGAAIAAPVAMALVVSTFAPGPPRNQAIAIFGSMMGVGSVGGLVVGGALAEWNWRLIFLINVPIGLLIILGAAFQLHDSAHHRLPLDVRGAFLGTFGCVGVVFGATEGPDLGWTSAYVIGALIAGLLLLVAFVLAERSAVNPLLPLTLFRDRDRSITFIALLLGSGVLGAMTYFVAQFLQNVVGYSPLVAGLASIPFTIGAGIGTGVASKAALMIRPRWLLAGAAAVLAAALFFGSTLDRSVEYLPTLLVLLAVVGMAIGFVIVVGPLCLLVGVPVNEVGPLSAIGQMILTLGTPFAVGLLTPLAASRTLSLGGRTDRTSNLTPTEVAALSSGYTFVLLICAIGAVIIGLLVLTLRYTPQQLAQAQHAQEEAQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG66</accession>
    <name>A0A231HG66_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47717">
        <property type="protein sequence ID" value="OXR47717"/>
        <property type="gene ID" value="B7C42_00842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="13984" checksum="85BC6432B0962BE2" modified="2017-10-25" version="1">MYTDNAGPRLRAGEPPIPEPVPPQPIPDPTSEHPIPDPDPRPPIPEPDPVPGRPPEPGRPIPGPSPDPIPGHPPPDPGRPVPPEPTPEPPPDPGRPIPGPAPDPGPDVPGRDPRPPVPQAGVSPAAGRAPAGHDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT52</accession>
    <name>A0A231GT52_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000063">
        <property type="protein sequence ID" value="OXR39799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39799">
        <property type="protein sequence ID" value="OXR39799"/>
        <property type="gene ID" value="B7C42_08128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="15010" checksum="4D608F2EC6FA8BC5" modified="2017-10-25" version="1">MTILLARPVRGVSVRSRKSPGNCAPDWGYAVVDFEPIPDGESSSVEFACAPCHDTELNDALAEGGLIELAGTGTHDPGRRRGEPVSARVVVRVIQQAEVDSCAAVYRGLGVLAVREMLNCLDQDRAPQPIITRISIGFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT78</accession>
    <name>A0A231GT78_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_08096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000059">
        <property type="protein sequence ID" value="OXR39834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782204.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39834">
        <property type="protein sequence ID" value="OXR39834"/>
        <property type="gene ID" value="B7C42_08096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR39834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="14828" checksum="E61CBF6D23D2445B" modified="2017-10-25" version="1">MTAITATQTTAAVRPGKIRNRVLWTLQVVLGLFFIIASGGPKLVMPHTLMENNATAFSIPLALLVFIGLAEVAGGIGLMVPRLTAAAAIGLAIVTFLAAGFNAFLAGAPELAPFPLVLTAIFAWIAYERRASITALGALIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT88</accession>
    <name>A0A231GT88_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pyrophosphohydrolase</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rppH_4</name>
        <name evidence="3" type="ORF">B7C42_08081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000058">
        <property type="protein sequence ID" value="OXR39840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39840">
        <property type="protein sequence ID" value="OXR39840"/>
        <property type="gene ID" value="B7C42_08081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="155" mass="17595" checksum="3121BA8735CA5843" modified="2017-10-25" version="1">MTETVAPQTARSKPQRHKVTGDVHLVLRRGSEVLFGQRQNTGFEDGAWHLPSGHLEADESVIDALIREAVEEIGVIIKPEDVHFAHIMHNSSSGGRMAFFFTVRAWKGEPGNREPEKCIELRWFSADALPDHMIDYCREAMEHIAHSRSFSVYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTN4</accession>
    <name>A0A231GTN4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate oxidoreductase subunit KorB</fullName>
            <ecNumber evidence="2">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">korB_2</name>
        <name evidence="2" type="ORF">B7C42_07938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779236.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39987">
        <property type="protein sequence ID" value="OXR39987"/>
        <property type="gene ID" value="B7C42_07938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="73"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="36412" checksum="3E90D3A2D45BBA8F" modified="2017-10-25" version="1">MTIVDIDTPVLRSGTALVPALAEGATQTAKDFSSDQEVRWCPGCGDYAVLKAVQSFLPDLGLRRENIVFVSGIGCSSRFPYYLDTFGMHSIHGRAPSIATGLATAREDLSVFVITGDGDALSIGGNHLIHALRRNVNMTILLFNNRIYGLTKGQYSPTSETDKITKTSPLGSIDHPFNPVSLALGAEASFVARTIDSDRKHLTSVLAAAAAHRGTSLVEIYQNCPIFNDGAFDAIKGPDAGETLLRLEPGVEVTVGNRTWAHDPNDPDPADQFALSRLSDHNARPGTAGKVPIGIFRQVQRPAYDDLARAQVAQAAASVEGSRADRLTALINSGDTWTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTW9</accession>
    <name>A0A231GTW9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_07946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779230.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39995">
        <property type="protein sequence ID" value="OXR39995"/>
        <property type="gene ID" value="B7C42_07946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR39995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="17411" checksum="DE2DC8B64B3FB31E" modified="2017-10-25" version="1">MVKIGPSGRRLTADDLHPGDEIELGSYLPTRAEIVEFASRWDPQPHHIDIEASRGGYFGDVIASGVHTLAIYQRLSVESALARWDVLAGVMLREVRLPAPVRPDRVLTGRIVVLEVDLGHPDRGRVVKEGVLLDPDGREVLRLVDESLIWRRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUN6</accession>
    <name>A0A231GUN6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IU_nuc_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40337">
        <property type="protein sequence ID" value="OXR40337"/>
        <property type="gene ID" value="B7C42_07598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="1">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="33140" checksum="2D02F38C6368AF4E" modified="2017-10-25" version="1">MTCNPTWPPLPASLDTPSVVFTDIGGDVDDAAALVLMAITDPQLALVDTVDEYPDHRRARSARHLLDVLARSDVRVVAGLSLGASGYWAADGLVPADIEVPPGDLYDVMSELCEAGSKSVRCLSLGPLTDIARLLVTDAHRSAPLDSERLLRVTAMGGALNYRNPERAGHNWRMNPASVQTVLAETEHVALVLSDHTPSTRSRYLRPRRCIGCWTRCRERRRSCCGSITTSSSVASTIRASSTTPSPRASCWGRGSCRGVGEFELRRDGRMREGPGTRAWLSDGVDYTLFMAWMEQIFRDVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUP9</accession>
    <name>A0A231GUP9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_27</name>
        <name evidence="2" type="ORF">B7C42_07519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40353">
        <property type="protein sequence ID" value="OXR40353"/>
        <property type="gene ID" value="B7C42_07519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="284" mass="29734" checksum="26BC28119E95C592" modified="2017-10-25" version="1">MASRYYPAGIRPVLMAGAAISTPLMRLGHMASFFLRMLGGIPVVLRHYRGEFLKLLSDVTWGNGSVVVGGGTGQVITVLGAAAGAIVGIEGYSALKLLGMAPATGMIASTAVTRELAPIMASIAFAAQAGCRFTAQLGSMRIAEEIDALDAIAIRPIPYLVTTRMLASIVAMIPLYLACLAFSYLAVEIVVGLSGGTSPGTYQHYFRIVLSGTDIVYSLSKAVVFVILTSTIQCYFGFYASGGPHGVGVAAGRAMRASITVMIFVNLLMTMTLWGFDTGARISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUR5</accession>
    <name>A0A231GUR5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40363">
        <property type="protein sequence ID" value="OXR40363"/>
        <property type="gene ID" value="B7C42_07529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="237" mass="25719" checksum="F06C9589CAA0E946" modified="2017-10-25" version="1">MLSTNLRAQQAILWSTPVIALVLLVLFAAFPGFVPPMSPNMTAAQVAQFYADNTALIRFSQVGFNLFGVLIVPFFVLIMGRMTRMGGQSHIFAFSYLGAIVAGVTLFALSNIVFGVAAFRPDRGPELVQTLNDLAWILFIAPIGMLLAQFVLLALAVHFDDGERPVFPKWVAPYSLVTAVAMAPSAGAAVFRDGPLAWDGFISFWLRNSAFAVFVVVMFFLVRAALGRQARDEAGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV73</accession>
    <name>A0A231GV73_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Haloalkane dehalogenase</fullName>
            <ecNumber evidence="5">3.8.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dhmA_4</name>
        <name evidence="5" type="ORF">B7C42_07346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.5" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40537">
        <property type="protein sequence ID" value="OXR40537"/>
        <property type="gene ID" value="B7C42_07346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018786">
        <property type="term" value="F:haloalkane dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="383" mass="42178" checksum="981D28563F701AB6" modified="2017-10-25" version="1">MTDTTITPFRIDIPQEDLDELNFRLARTRWTDALPGVGWSYGVDRDYLIDLAEYWRTGYDWREHESRLNKVPQFLTEIDGQTVHFMHVRSPEPDATPLIITHGWPSTPADFLDILGPLTDPRAYGGDPADAFHVVAPSVPGFGFSGPTHETGWDVPRIARTWATLMERLGYERYGAQGGDYGSLISPALGRVAPDKVIGVHVNALADAATATGSGRELDDLSEADRAKAVANQMWWYGHNGYATQMALRPQTIAYALNDSPVGQLAWNLEWFVDWDPTATDQAPVDRDIILTDVTTYWLTGTAGSAARIYRESGASWGSRPAPSGVPTAVANFRGDRAVRGLAESANTIVRWNEYAVGGHFASLQAPVELVADIRDFFRSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVI3</accession>
    <name>A0A231GVI3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40639">
        <property type="protein sequence ID" value="OXR40639"/>
        <property type="gene ID" value="B7C42_07324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="17107" checksum="9254831F04FCAD82" modified="2017-10-25" version="1">MICESIERISRFTHTGTTIEHELQQHGVRLLAADEPFTLATNGIRKQKVATQVLTRRVKQSIAEFYVTEMLEKSWDGFAVHTEAGYNVGKPPYGYRAKPVPHPVPAKRARGHKKTRLEPDPIQGPVVQKIFRWRWEENLSHQAIADRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVJ1</accession>
    <name>A0A231GVJ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type-1 restriction enzyme specificity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hsdS</name>
        <name evidence="5" type="ORF">B7C42_07335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234281">
        <property type="entry name" value="S.Nce30759ORF7336P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40650">
        <property type="protein sequence ID" value="OXR40650"/>
        <property type="gene ID" value="B7C42_07335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="378" mass="41233" checksum="9D64DC6C91E49CC3" modified="2017-10-25" version="1">MSDWRSVTIGELLTLEYGKPLPEAARDGQGFPVYGSNGIVGFHSQALVKGPGVVVGRKGSSGTVTFSESDFTPIDTAFYVSIKNRSEIGMEFVYHLLANAKLTELTTQTGVPGLSRSRAYEVRVAVPPLPVQLRIVEMIGAVDDQITALDAEAESLHAVLRRLRTELVDDQGVPTIRADEAFEIRMGRQRAPQYAAGPYMTPYLRSANVGYGTLDLTDVLEMNFDPKERQVFGLVPGDVLVSEGSASQSAVGMPAVWRGELPGPICFQKTLMRYRAIEGISVPAFVNHWCLWAYESGTFLDTAGGTNIKHITAMRAVRMPVRLPSVADQVRIAAELDTMSEAVAAVRAEEYRLRAVRARLLGALLDRTIDLKSAESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW08</accession>
    <name>A0A231GW08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-succinylbenzoate--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menE_5</name>
        <name evidence="4" type="ORF">B7C42_07097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40813">
        <property type="protein sequence ID" value="OXR40813"/>
        <property type="gene ID" value="B7C42_07097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="439"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="528" mass="57575" checksum="7503A0C64814806D" modified="2017-10-25" version="1">MRKRGLFSPLRPDHAVSSALNVTKFGPFAGVIMHAAKTNPKSAALLDERGELTFAEVNEQSNQLARGLAAHGLREGDVVALLARDHRGMVLSLAATGKLGVRAVLMNTGFAKPQFADVATREQVKLVLHDSEFFDLMSAIPDEIPRILTWVDESDNVDPAIPTVDSLREGHSPDPVAAPAKPGGMVILTSGTTGTPKGAPRDKVSPFISAQFLDRIPLPRNGSMVVAAPVFHATGLSQFTLGLSLGNRMIFQQRRFDPEKTLANIDKYKAESLVVVPTMLQRMLDLPPETLAKYDMSSLRMIFAAGSAIPPDVVTRSLDYFGDVLYNVYGSTECALITVASPEDLRKSPSTAGRPPLGIRLALFDENRKRITEPNVTGTIFIENAHSFKAYTDGRTKETIDGMMSSGDVGHFDEDGLLFIDGRDDDMIVSGGENVFPQEVEHLIADRADVQEAAVVGVDDKEFGKRLRAFVVPGPDSQRDAQEIKDYVKANLARYKVPREVIFLDELPRNATGKLLRKPLTEMDVTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW47</accession>
    <name>A0A231GW47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40853">
        <property type="protein sequence ID" value="OXR40853"/>
        <property type="gene ID" value="B7C42_07137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="49" mass="5419" checksum="FD427B3BDA0A6FE9" modified="2017-10-25" version="1">MVGVIEYADDDHTIDAVPELVPAFGVLERVEDEQGPVSMDVPGEYRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW58</accession>
    <name>A0A231GW58_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metallo-hydrolase YflN</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yflN_2</name>
        <name evidence="2" type="ORF">B7C42_06994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043669.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40859">
        <property type="protein sequence ID" value="OXR40859"/>
        <property type="gene ID" value="B7C42_06994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="24884" checksum="6CD36CB16D4171A4" modified="2017-10-25" version="1">MEIVSVLPQLTALRFSQVNDLNVYVWSDLEGVTLIDCGLPGTAGEIERGLRTCGFTRDQVQRVILTHAHDDHIGSAADLAEWGAEIWAHHADADIVRGERPQPAPVLREWERPIADALEPGTPPRPAPVHRELRGGDVLDFGGGAEVLAVPGHTDGSLALHLPQHRVLFTGDTLANVRGVTTPGVFNLDSTAVDTAARRLTELDVDIVCVGHGDVLTGTPLRTWRGHGSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW90</accession>
    <name>A0A231GW90_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1775 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043513.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40887">
        <property type="protein sequence ID" value="OXR40887"/>
        <property type="gene ID" value="B7C42_07022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011295087" description="DUF1775 domain-containing protein" evidence="3">
        <location>
            <begin position="37"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="42"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="26191" checksum="5A8E2988235FE189" modified="2017-10-25" version="1">MADSDIREWRAPVRRHLVRRWSAAAIAAAVPLVAYAAPAAAHVQSDGTPVTKGGYGVVHLIVPGESATANTVGLTVTIPAGVDLKSARTQPIPGWTASIERDQAAGRVTKIVWNANTPSDGFGTTQYREFSFSAGPWPKAVDSVALPSDQRYSDGSVVSWNETAVDKSSEPEHPAPVVPVTATAAGHSDDGGHAVSAANTSPDRHDDAALHDGGESSPSGWWQALSVVALLLAVAAGAAATLALRRDREPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWC1</accession>
    <name>A0A231GWC1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aliphatic sulfonates-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ssuA_8</name>
        <name evidence="2" type="ORF">B7C42_07065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783769.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40930">
        <property type="protein sequence ID" value="OXR40930"/>
        <property type="gene ID" value="B7C42_07065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011295088" evidence="1">
        <location>
            <begin position="28"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="34257" checksum="F0786DEBC65DF979" modified="2017-10-25" version="1">MIEVLRRRVIAGAVVVAALVLATTACARPATQATGNASDLVRISVGVDASYAPFFLADSEGMFAAAGLHVQIIQTEGGAASAQNVVAGTSELSGNADSTALTVMAGNPGLRALGVYEDSDRYFRVVLRGGATPKSIRKMGVFPGIGLYFTDRYLRSLGVDPASITLVTTSPPEQPALLARGDIDAFISYDPWVARAVGSNGHVVGTTGDFGARYSQWLLASQSWLSTHERLAGQVFRVLAQAADIIAADPSRAAKAVAAAIRMDPGEARDQITQIDFRGRDFRPDDFEQARELVDFFRGQGKLAGPVPPQEVMLAGWFGRNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWM5</accession>
    <name>A0A231GWM5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41027">
        <property type="protein sequence ID" value="OXR41027"/>
        <property type="gene ID" value="B7C42_06797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040611">
        <property type="entry name" value="TetR_C_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18556">
        <property type="entry name" value="TetR_C_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23578" checksum="0D772CE9BE5A78BA" modified="2017-10-25" version="1">MTAEAARDTVAGMPRNGSRVPYQEAARTLLRTSVLDAMRELLIERDWAKITLGDVATRAGVSRQTLYNEFGSRTGLAQAYALRLADQLVDHVGTAIADNVGDARAAFREGLANFILDSAADPLVQSLVVGEAKLDLLRLITLDAGPLIEHAARRLGAAFENSWVGASAAQADVLAHALVRIAISYIPTPAALHRDAPEELSSLLAPYVEAILAARDRTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWQ9</accession>
    <name>A0A231GWQ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribosome biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsgA_2</name>
        <name evidence="2" type="ORF">B7C42_06824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41054">
        <property type="protein sequence ID" value="OXR41054"/>
        <property type="gene ID" value="B7C42_06824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENGC_GTPASE" evidence="1">
        <location>
            <begin position="83"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="31780" checksum="B39B903456D2E0A3" modified="2017-10-25" version="1">MVVSVDRGRWGCVLGDDPDRRVVAMRARELGRTPIVVGDQVDVVGDLSGRPDTLARIVRVADRRTVLRRTADDTDPFERIVVSNAEQLFIVVALADPPPRTGFVERAMVAAYAGGLQPILCLTKDDLAADSEFASEFADLDLTIVYGGRDDPLEPIRELLRDSLTCLLGHSGVGKSTLVNRVVPEAERAVGTVSGVGKGRHTSTQSVALPLEGGGWVIDTPGIRSFGLAHISPDDVIAAFPDLSEAIEDCPRGCTHLGPPADPECALDALPGKERRVAAIRLLLTALNSNDPWVLGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWR2</accession>
    <name>A0A231GWR2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mtrB</name>
        <name evidence="11" type="ORF">B7C42_06806</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41036">
        <property type="protein sequence ID" value="OXR41036"/>
        <property type="gene ID" value="B7C42_06806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="231"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="298"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="522"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR41036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="645" mass="68722" checksum="39D9A2E7760CF440" modified="2017-10-25" version="1">MIAGSRSRVERLLAAVVAWFKSVGESLGHTWRRSLQLRVVVSTLTLSLIVITILGVVLTSQITDRLLDAKVNAAVEEMSRARNTVEAQLTGVSDSSTQAVRLQDAVRALSSGGSSSATGGAGTYNVALAMVGDGQQEVTAGPMLEVPAELRRFVQQNQVSYQFATISDPDGYRGPALIIGSPSSEVPTLEVYLIFPLNNEQRSLSLMRGTMLIGGIVLLLLLAAITALVARQVVLPIRSAARIAGRFADGRLKERMLVRGEDDMARLAMSFNEMAESLSNQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIHGSSDELDPALARSAELLVTELDRFEGLLNDLLEISRHDAGVAELQIESLDVRMCARAAVSTVRHLAKESGCELVVDLPEEPLVAEVDPRRVERVLRNLLANAIDHSENKPVLIRMRGDVDANAVAMVVRDQGVGLRPGEEKLVFNRFWRSDPSRMRRSGGTGLGLSISVEDANLHDGRLEAWGEPGVGASFRLTLPLVRGRKLGASPLSLEPPKRRLADLPAGSVDAAGDPVDPAPEADPAGDAPDPANPAASATPADGPDGPANVPGTVEANADAEPSARTTPAEEDSPDSPDGEPAAERRSPNPAGESAGGSDDTARADKEDINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXA2</accession>
    <name>A0A231GXA2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase TesA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mbtB_3</name>
        <name evidence="7" type="ORF">B7C42_06726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41131">
        <property type="protein sequence ID" value="OXR41131"/>
        <property type="gene ID" value="B7C42_06726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="PKS_TE" evidence="6">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="27864" checksum="59F7D0A91E6DBD8E" modified="2017-10-25" version="1">MGNSWLRRLSPAPENGSHTVVCFPHAGGSAISYGPLARSLGSEYDVVAVQYPGRQDRRREPLVGTISDLVDGLFTELTETLAGVSHFSLFGHSMGSAVAFETCRRLERDTETRAAVLFASGRRAPSQQGTEVMHTLSDRALADHLLNYGGTPAALLEDPEMRDMILTVTRNDYRAIETYACAPGATVECPIVALAGDRDADASLADIEAWRAHTTGDFLARTFPGGHFFLDANRDAMAQLISQHSSRALSNQAAATGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXB0</accession>
    <name>A0A231GXB0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_26</name>
        <name evidence="9" type="ORF">B7C42_06637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41239">
        <property type="protein sequence ID" value="OXR41239"/>
        <property type="gene ID" value="B7C42_06637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="41699" checksum="FEA78559F4430530" modified="2017-10-25" version="1">MDRSVYTDDHERFRTSVHDFLAREVAPRVEEFADQKLIAREVWRAAGDQGLLGLEIPEEFGGGAAGDYRFNAAAMEELAAVAMALASSLSIHFDVVTPYVVDLAAEEQKRQWLPRFASGEVVSAIGMTEPSAGSDLANVKTTAVRDGSDWILNGSKTFITNGYTADVVVVAARTNPEQRSKGISLFLVDASLPGFERGRKLDKVGQPEADTAELFFDAVRLPADAILGEVDRGFVAMMERLPQERIGAAVINVAHAKQILLETIDYTKQRKAFGSAVGSFQHNKFLLAELVTKIEVAQAYVDAGVAAHAAGELTPVDAAKAKWWTAQVQNEVLDHCVQLHGGYGYMREYRVARAWMDARVSKIWAGSNEIMKEIIGRDLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXD9</accession>
    <name>A0A231GXD9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxymuconate semialdehyde hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylF_4</name>
        <name evidence="2" type="ORF">B7C42_06646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.9" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41248">
        <property type="protein sequence ID" value="OXR41248"/>
        <property type="gene ID" value="B7C42_06646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018775">
        <property type="term" value="F:2-hydroxymuconate-semialdehyde hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="30357" checksum="3166B2FFB24C8C31" modified="2017-10-25" version="1">MTATTTLETGRFIDVDGISTHYHDAGDGKTVLLLHGSGPGVSAWANWHHALPALARSSRVVALDLVGFGLTERPADVRYSLRTWTDHAWKFLDALAIEKISVVGNSLGGRIAMQMAEDDQSRLDRLVLMGSPGVGMTMTEGLEALRAYEPSHQAMRDLLRDYFAVDKSMITDELVRIRYEASAAQGAHEAYRTMFFHPDHAGSQLGITEEQVRAITVPTLLIHGREDRVVPVDVSWNMVHLLPDADLHVFSRCGHWTQIERADEFNRLVADFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXV7</accession>
    <name>A0A231GXV7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">27-O-demethylrifamycin SV methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.315</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.315" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41405">
        <property type="protein sequence ID" value="OXR41405"/>
        <property type="gene ID" value="B7C42_06548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="213" mass="23355" checksum="1D2185AF84D6F1BA" modified="2017-10-25" version="1">MSATSPTEPAVFWEQRYRDSDRVWSGNPNPLLVRETAELRPGRALDLGCGEGADAVWLAGQGWQVTGVDISQTALERAAAHAEQAGVSERVSWERHELGRTFPDGSYDLINAQFLQSPVALDQDGVLRRAADAVAPGGTLLIVMHAGWPTWMTPEEHPFDAIFPTLDGVLHALRLGAEWTVRTCEPVERTLTSPDGRSGTRADNVWRLFRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYM8</accession>
    <name>A0A231GYM8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036508398.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41685">
        <property type="protein sequence ID" value="OXR41685"/>
        <property type="gene ID" value="B7C42_06326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="180" mass="20041" checksum="C06CA4BC7C5F8F7D" modified="2017-10-25" version="1">MSTALSPRISRLRQLIDHPATGAAERDAAQRMLDRILAKHPQAAGPRGDRDYGPRYHRVGRHATLASIAEMISQDIAFAKIFSMPQHRAELAERSPIRDAPIEISYSVATPYVGKIIVTIEGVPREWGWVSDCGIDNPSPALQELADELAEIMNAYNHDGSDIGKRFFACVRVPERTLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYR6</accession>
    <name>A0A231GYR6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mog</name>
        <name evidence="3" type="ORF">B7C42_06106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.75" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41764">
        <property type="protein sequence ID" value="OXR41764"/>
        <property type="gene ID" value="B7C42_06106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="45"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="20126" checksum="2D1C3D9BC0358D92" modified="2017-10-25" version="1">MIREPRPLTVLPTPDADEPGGPEWLSPTDATVSNMEIDAPVAGRALVVVVDDRTAHGGVDSLGPLVTELLTEFGFLVDATVSVAGDEIEIRNALNTAVIGGVDLVISVGGTGMSPRDVTPEATLEVLDRELPGISEALRASGLAAGSLDAGLSRGLAGVSGSTLVVNLPGTRDAVRDGMATLGPLVSRVVDELSGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ37</accession>
    <name>A0A231GZ37_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(S)-1-Phenylethanol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.311</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ped_3</name>
        <name evidence="1" type="ORF">B7C42_06202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.311" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41860">
        <property type="protein sequence ID" value="OXR41860"/>
        <property type="gene ID" value="B7C42_06202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="25488" checksum="E541F9394B3FBEE0" modified="2017-10-25" version="1">MTPTTTPTTTGRVAAVTGGAGAIGSAIADRLRIDGHTVVVLDRPRDDRDGGTDIGVDLADERSVRDAAARVLDAYGRCDVLVHCAGAFETADLRGLDTTIWRHVQAVNVESALWLAQVFTPAMAQRGFGRIVFVTSDTQWEPPGPQLLPYIASKGALTALTRVLARDLGADGIAVTAIAPGLTDPPGSRTVNTEADFEAVVARQALRRRLTPADTADTVAFLATDAAAALTGQTVCVDGGLVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ72</accession>
    <name>A0A231GZ72_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anthranilate 1,2-dioxygenase large subunit</fullName>
            <ecNumber evidence="8">1.14.12.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">antA</name>
        <name evidence="8" type="ORF">B7C42_05859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.1" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41875">
        <property type="protein sequence ID" value="OXR41875"/>
        <property type="gene ID" value="B7C42_05859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018618">
        <property type="term" value="F:anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="57"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="44864" checksum="5F983D93667D309A" modified="2017-10-25" version="1">MTEVGAPREERIRRALTHLRNDTTDEFGHVTWFEPTEFTDPAVAQRERDLIFGRVPSIVAHGSEIPRAGDFFTLQMPRNNIIVGRQRDGGVKALVNLCRHRGALLEKEEKGRCRLFSCPYHRWSYDMDGSLRTITRDNTFGEPERATLGLIELPTEERHGFIWVVDDADAEIDVASWLGPDMDAVLASYDLQSKVCVQGEGFDEPVNWKIMQDAFLDGYHIQYAHPNTAAKHIHTNVMAFDDFGRHCRFIAPRKSIDRWIEEDPGDRSLAGDITETHFLLPNSTLLRQPDHFQLLTFRPHPSDPQRSRMEMRLIVPPVEQTELTEEKWTRLWDKNWQILLDVLHAEDFPLLRDSQRGMTSASAGRMVLGQNEVANQVFRRETQKLLTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ82</accession>
    <name>A0A231GZ82_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-arabonate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araC</name>
        <name evidence="3" type="ORF">B7C42_05913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41929">
        <property type="protein sequence ID" value="OXR41929"/>
        <property type="gene ID" value="B7C42_05913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050020">
        <property type="term" value="F:L-arabinonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="561" mass="59802" checksum="CABFDE2B0F9F2899" modified="2017-10-25" version="1">MTALYLERFLNYGLTRAELQSGRPIIGIAQTGNDLVPCNRHHLALADRIKDGVRDGGGIPFEFPVHPLQETGKRPTAALDRNLAYLGLVEVLYGYPLDGVVLTTGCDKTTPACLTAAATVNMPAIVLSGGPMLNGYHRGMRTGSGLVIWQSKRLLARGEIDYDEYMARVTASAPSIGHCNTMGTALSMNSLAEALGMSLPGCASIPAPYNERAQMAYATGLRAVSMVREDLTPRKIMTTRAFENSIVVASAIAASTNVPIHINAIARHVGVELSNQDWQRVGHGIPVLVNLAPAGEFLGEDFHRAGGVPAVMRSLLEAGYLHGDAVTVSGRTVAENLEDVPPADPAVIRPVHDPVTANGGLLVMSGNLFDSAIMKTSVITGKPPAFDYRAIVFDGPEDYHARIDDPELGIDQDCILVIRYTGPIGYPGSAEVVNMELPATLIQQGIMALPTLGDGRQSGTSDAPSILNASPEAAAGGNLAILRTGDRIRVDIDNARVDALLTAEEIAARWADYTPPALEHQTPWQEIYRSTVGQLDSGGCLELAVSYQDLVHTKGIPRDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H075</accession>
    <name>A0A231H075_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low-affinity putrescine importer PlaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">plaP</name>
        <name evidence="6" type="ORF">B7C42_05821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42222">
        <property type="protein sequence ID" value="OXR42222"/>
        <property type="gene ID" value="B7C42_05821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="446" mass="46159" checksum="C872B1D20AD9DE69" modified="2017-10-25" version="1">MAGMPHSLKRAVSTPLLYFFILGDVLGAGVYVLIGSVAQASGGAVWLPLAVALGMATLTAASYAELATKYPRAGGSAHYATRALGPAAGSLVGFCMLAAGVVSVGALARAFAGDYLQALVSAPTAVVIVVFLAALAALNIRGIKESLRANVAASLVELSGLVLIIGLGAWILLRGDADPGRLTEIGTAEHGPVAAVLAGTVLAFYSFVGFETSVNLAEEVRDPRRSYPIALFGALLTAGVVYVLVGVVASAAVPTDELARSSGPLLEVVRRAGGVPDRLFSVIALVAVANGALLTGIMASRLAYGMARDGLLPAVLTRLLPGRRTPWVAVVVTSGASLALALTGEVAVLAETLVLLLLVVFAAVNCSVLLERRHPVDTDHFRVPTLVPWLALASCLYLFTRIDAEIWERGLILVGLGAVLALVNGLRTRRAHPESRITQAVKTMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0I6</accession>
    <name>A0A231H0I6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative bifunctional transcriptional activator/DNA repair enzyme AlkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alkA_2</name>
        <name evidence="7" type="ORF">B7C42_05470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42271">
        <property type="protein sequence ID" value="OXR42271"/>
        <property type="gene ID" value="B7C42_05470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="90"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="541" mass="58046" checksum="F22747A36A45CB96" modified="2017-10-25" version="1">MSVNGLDFERCYRAVATRDARFDGHFVTAVRTTGIYCRPSCPAITPKRTNVTFLPTAAAAQQNGFRACRRCLPDAAPGSPLWNTRADLAARAMRLIADGVIERSGVPGLADKLGYSQRQLTRVLTAELGAGPLALARAHRAHTARLLIQTTRMPMSDIAFAAGFASIRQFNDTVREVFVVSPTVLREEARRLRGDTLPATNGALTLRLPYREPLDASWLEWFLSAHAVPGLESWEDGVYTRSLRTPHGHATVRASIHPGHVRASLALHDMRDLAPTVARIRHLLDLDADPVGIDAALTEGFGPGAPAISAGIRVPGCLDGSELLLRTMIGQQISVSAATTHTARLVDALGDNVNGPMPRLFPTAEAIAERGADVLTGPARRTASIVGAARALASGDLRLHAGRTAADVRRDLLAIDGVGPWTADYVTMRLLADPDILLHTDLVVRQGAAQYGIDLTDTSRWAPWRSYLSMHLWKRALSERTAVATTARAASARNGGYPAGRDDATRPTPARAALDRRGDAARPGAAAADAGRRTAYLGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0L6</accession>
    <name>A0A231H0L6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Redox-sensitive transcriptional activator SoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">soxR_2</name>
        <name evidence="8" type="ORF">B7C42_05636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780723.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42435">
        <property type="protein sequence ID" value="OXR42435"/>
        <property type="gene ID" value="B7C42_05636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01110">
        <property type="entry name" value="HTH_SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="183" mass="20516" checksum="18BC328E5045C172" modified="2017-10-25" version="1">MQHTTWQAKELTPGQLSERSGVAVSALHFYEREGLIASRRTSGNQRRYSRETLRRVAFIRISQRVGIPLSEIRKALDTLPEGRTPNRKDWERLSVTWRTDLDQRIEQLTRLRNSLTDCIGCGCLSLGSCRIVNYHDRLGDEGPGARTLDVSIDCTKAEGCEEPSLDNPPVDAEVAACAEKMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H137</accession>
    <name>A0A231H137_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">(R)-benzylsuccinyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bbsG_4</name>
        <name evidence="9" type="ORF">B7C42_05350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.3" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42573">
        <property type="protein sequence ID" value="OXR42573"/>
        <property type="gene ID" value="B7C42_05350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033734">
        <property type="term" value="F:(R)-benzylsuccinyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="246"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="45264" checksum="76B5FEEABC3576F6" modified="2017-10-25" version="1">MSMFDISERAEKYRAQLLEFMDSHVYPAEAVYDEQMRAAGDPHFQPPILEELKAEAQRRGLWNLFHPYPEWGPGLTNLEYAPLAEIMGRSHLAPEACNCNAPDTGNMEVFTLFGTDEHKEKYLKPLLAGTIRSAFAMTEPAVASSDATNVELSMVRDGDEYVLNGRKWFASNALHPNCTVLIVMGKTDPDAAPHRQQSMMVVPIDAPGVTVMRGLPVFGYQDREGHAEIVFQNVRVPLKDVLKGEGEGFAISQARLGPGRIHHCMRAIGMAERALELMCRRASTRITFGKPIAANANIQDWIAEARIDIEMIRLLTLKAAYLMDTVGNKEARTEIAAIKVAAPNIALKIVDRAIQVHGGAGVTDDFPLAMAWAHLRTLRLADGPDEVHKRTLARQELRKYRDVKADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1D6</accession>
    <name>A0A231H1D6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLP1_add_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42656">
        <property type="protein sequence ID" value="OXR42656"/>
        <property type="gene ID" value="B7C42_05434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLP1_add_C" evidence="1">
        <location>
            <begin position="421"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="506" mass="53541" checksum="8DF48492CC495720" modified="2017-10-25" version="1">MVDSRTPVVVGVGQAIDRIDTSDYRQMSSVDLAAAAARAALEDTGIRYTAAAASVQLIAGVRQFEISAPVRAPLGRSDNYPRSVARRLGIAPARAVLEVVGGQGPQHLLTEFAAEIAAGRLESVLITGSDAISTERYYAGRDDKPDFTETVGGQLEDRGFGYESFVDDNLIAHAVMGAPTQYGLLENARRARVGATPQQYRLDMGKLLAPFTSVAAKNPLAAAPVERSAEELAAVTDANRMICDPFPRLMVARDLVNLGAAAVVMSLGRARELGVPDDKLVYLRGHADLEEQTLLARPDLGAAPTAWAAAREALRVAGIGIDDLTTLDLYSCFPVAVFNFCDGTGLATDDPRGLTVTGGLPFFGGPGNNYSMHAIAETVARMREQPGAFGLVGANGGIMSKYSVGVYSTTPAPWAPDRSAELQRAVVAAPRVPSRARADGPARIETYTVRHAFEPRTGLVVGRLHADDSRFLALMAPESLAAVDDPIGRDILVTSSEKGNTAVMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1H5</accession>
    <name>A0A231H1H5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminopeptidase</fullName>
            <ecNumber evidence="2">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42698">
        <property type="protein sequence ID" value="OXR42698"/>
        <property type="gene ID" value="B7C42_05034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="35230" checksum="94DBA132387BB506" modified="2017-10-25" version="1">MTSVPGPRDSITDVAGVLVGHHHELDPDATLGSGAATGCTVVRVPGGATASVDVRGGGPGTRETDLLDPGQTVRQVNAVLLTGGSAYGLAAADGVMRRLEEDGEGIPMDPADPSRVVPIVPGAVIFDLPVGAWDIRPTAEFGYRATRSAGETFECGSVGAGTGARAGSIKGGIGTASVRFTAGPAAGHTVGALVVANPVGSVFDPRTGLPWGAGTDGPEHFGLAPATAEALARANALPVKGTVLNTTIGVVATDAALDPAGCRRLAVTAHDGLARAIRPAHSPLDGDTLFALATGTTTAESNIPLPPAFPADLLLLDELCTAAAVCVERAIVDAILRANPVAGIPTYRELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1I3</accession>
    <name>A0A231H1I3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_05038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42702">
        <property type="protein sequence ID" value="OXR42702"/>
        <property type="gene ID" value="B7C42_05038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="107"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="26744" checksum="37C134AF9D198BC5" modified="2017-10-25" version="1">MAEQMGPSFDPDRIAALRAELQKSAGTPAGSVPSGSQFPSPRPAAAAPASASEPGRTAALKLLWQRAIAMTLTFVALLYAVEGVDTVSHHDLDAAGVRPRTAEGLEGIVFAPVLHANWAHLLGNTLPVIVLGLLTLLTGIGRGLAATAIVWVVAGVGTWLTGASGSVHIGASVLVFGWLTYLISRGLFTRNLWQILVGVVVGLLYGSILWGVLPGQAGISWQGHLFGALGGLLAGWVLSSNERRHRRGESAGRLASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1R5</accession>
    <name>A0A231H1R5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 130</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42795">
        <property type="protein sequence ID" value="OXR42795"/>
        <property type="gene ID" value="B7C42_05133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="399" mass="45021" checksum="C79F44BD91807A00" modified="2017-10-25" version="1">MTISTAGDVHYDPYDVELNADPYPMFQRLRDELPLYYNAQHDFYALSRFEDVNVGLIDKDTFISGRGAILELIKANIEIPSGVLLFEDPPVHTIHRKLLSRMFTPRKIKALESKVRDFCAESLDPLVGTGRLDFIADIGARMPMRTIGMLLGIPEEDQEAIRDFANEQMRTEEGKPMRAASEGMVSGDIFGPYIDWRAEHPSDDIMTELLNVEFVDETGTERRLTRDELLMYVNVVSGAGNETTTRLIGWAGKVLADHPDQRRLLVENPALIPQAIEELLRFESPAPHTCRYVTREVEYHGQKVPEGSVLMFLIGAANRDHRHFAPDGDVFDILRAPQPHLAFSVGTHFCLGSALARLEGRIAVEEILKRFPEWEVDLSQARLSPTSTVRGWESLPAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H275</accession>
    <name>A0A231H275_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="10">PRA-PH</shortName>
            <ecNumber evidence="3 10">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">hisE</name>
        <name evidence="11" type="ORF">B7C42_04832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PRA-PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="3 10"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518144.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42946">
        <property type="protein sequence ID" value="OXR42946"/>
        <property type="gene ID" value="B7C42_04832"/>
    </dbReference>
    <dbReference type="GeneID" id="66719565"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR42946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="9750" checksum="26DB22C22C2DF635" modified="2017-10-25" version="1">MKTFETLFAELQDRAANRPEGSATVAALDAGVHAQGKKVIEEAGEVWIAAEHETDEQLAEEISQLLYWVQVLMVGRGLRLEDVYRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2I1</accession>
    <name>A0A231H2I1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="3" type="ORF">B7C42_04923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778002.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43037">
        <property type="protein sequence ID" value="OXR43037"/>
        <property type="gene ID" value="B7C42_04923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="21459" checksum="2C07F82A88DF9DD1" modified="2017-10-25" version="1">MSLAMVMSLADSRLPIGGHVHSGGVEEAVTSGLLRDVDTVAAYLRRRIRTTGLVAASLSAAVCAGALTPSAAEAEADARTPAPAARTASRAQGRGLLRLAKQVWPQHDWSGLGARPHLSTVFGVVGRAAGVRPVEIAGVVVYTTMTGAATAAQRLLALDPAAVAAITLELAALCDDTARTAAIGPAALSDPLGDVLAQRHLDREMPLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2L2</accession>
    <name>A0A231H2L2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">ureC</name>
        <name evidence="13" type="ORF">B7C42_04934</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43048">
        <property type="protein sequence ID" value="OXR43048"/>
        <property type="gene ID" value="B7C42_04934"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="136"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR43048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="573" mass="60812" checksum="16AEA91AD2071228" modified="2017-10-25" version="1">MAELSRAHYATLFGPTVGDRIRLADTDLLIEITEDRCGGPGLAGDEAVFGGGKVLRESMGQARATRAEGTPDTVITGAVIVDYWGIIKADIGIRDGRICAIGKAGNPETMDGVHPDLVVGPSTEIIAGNGRILTAGAIDCHVHFICPQLLDEALGGGITTLIGGGTGPAEGSKATTVTPGAWHLGRMLEATDGWPVNILLLGKGNTVRPEVMWEQLRGGAGGFKLHEDWGTTPAAIDACLRVADAAGVQVALHSDTLNEAGFVEDTLAAIAGRAIHSYHTEGAGGGHAPDIITVASHPNVMPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPAVPEDLAFAESRIRPSTIAAEDLLHDLGAISMIGSDSQAMGRIGEVVMRTWQTAHMMKRRRGALPGDGAADNHRVRRYIAKYTICPAVTHGLDHEIGSVEVGKLADLVLWEPAFFGVRPHAVLKGGAIAWAAMGDANASIPTPQPVLPRPMFGAAPVVAAGTSLHFVSPQAVEDGLAERLQVRRRLVPVADVRRRTKSDLPLNDAMPRIEVEPDTFTVRIDGEVWDQQPAAELPMAQRYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H355</accession>
    <name>A0A231H355_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acdA_5</name>
        <name evidence="9" type="ORF">B7C42_04735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009537.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43313">
        <property type="protein sequence ID" value="OXR43313"/>
        <property type="gene ID" value="B7C42_04735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="42986" checksum="BB532A40AD9BBB1B" modified="2017-10-25" version="1">MDYGMSPELERFRLEVREFVEANAPAIPPKAGVRSAENRAEHALITEWIGKLYAAGYMGGDWPEQYGGQGSSYSAERDVVVGEEIARAQAPHFAGAGTLVSYALIDFGTEEQRQRYLPGIRSGADTWCQLFSEPGSGSDLASLRTKAVRTEGGGFRVTGQKVWTTNGHWADYGYLLARTDPGVPKHQGISAFIVDMSLPGVDVRPLREMTGTSDFNEVFLDNVELPADALIGELNAGWAIANSSLGHERSGVATSVVRLRGNVDALEDLAKRINRDGRPGIQDGAVQETLGKFRAEVEALSALVYANISRWSRGTERVQDAPMAKLMFSELGVDISRFALELCGEAGILVEGDPAAVDRGRWQDEFLYARAYTIAGGSSEIMRNIIAERGLKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H379</accession>
    <name>A0A231H379_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiocerol synthesis polyketide synthase type I PpsC</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ppsC_3</name>
        <name evidence="2" type="ORF">B7C42_04726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43304">
        <property type="protein sequence ID" value="OXR43304"/>
        <property type="gene ID" value="B7C42_04726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="328" mass="34162" checksum="1125422CE966C4D1" modified="2017-10-25" version="1">MRAVRCDTYGGPESLTVTDIPAPEAGPGQVVVRVEAAAVNSPDVLVAADRYQISVPTPFTVGSEFAGTALAVGSGVRAVAPGDPVMGVAFTGAFAEQIAVPEGALSPIPDGLSMIHAAAFGVTYRTAYHSLVTVGEMRPGDWVVVLGAAGGVGTACVDIATRLGGRVIAAAASWERVELCRRLGAVAGIAYEYENLKDRIKAITGGRGADVVIDPVGGAHAEQSIRATGWGGRYVCVGFANGEIPRIPMNLVVLKGAILRGFEIRTLAEHRPDAVSEGTTAIARMISEGMRPHVSEVFALEDAPRALTLMRDRGARGKIVLDPTMRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3D0</accession>
    <name>A0A231H3D0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43371">
        <property type="protein sequence ID" value="OXR43371"/>
        <property type="gene ID" value="B7C42_04238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="30064" checksum="AB1DDEF5339A6932" modified="2017-10-25" version="1">MRSDTLAVPGATLYYEMRGDGPLLLAIPGGGGDAGVFDEMAEILQHHFTVVALDPRGYSRSVLDSGPEPQQVAVQADDVARLLAHLTDEPAFVFGTSNGAIVGLDLLARHAGRVRRLIAHEPPCFAVLPDAGEHLAMVAQVYDLLHTDGLAAAGARFLAGIGPAMKPAPEVSQLSERAARMWARLADNGPLMIEHELREFTSYTPDYRALELVSDRLVLAVGRETRGCLPYRPAVEIGARLGPAVVEFPGAHNGIRTEAVEFAHQLVEVLAAERASTPDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3X2</accession>
    <name>A0A231H3X2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43545">
        <property type="protein sequence ID" value="OXR43545"/>
        <property type="gene ID" value="B7C42_04413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="325" mass="33777" checksum="4495B802888AD056" modified="2017-10-25" version="1">MQAIVMTEVGGPEVLVARDVDEPSPQPGEVLIRVEAVPVLYPETMLRSGMYPTPKPTPTVFGTQAVGVVTAVADDVDPEWKGQRVLLARNDFGSYAERMCAPAESAVRIPDGLASDAAAAVAMSGSVALALLEAAALTGTETVLIEAAATGIGGYLTQLAARSGAAHIIATAGGTAKTERARELGAHTVVDHRDPDWPRHLGARLDTTTVDVVFDSIGGESAAAVLDLMTPLRGRMLGYGWLSGAPAQLTTMDLIMRGLTFTGCSGPQWLAGVAAKRAAAFELAATGDLTVLIDSVLPLADAAEAHRRVDDRATFGTIILRPETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H404</accession>
    <name>A0A231H404_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778909.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43619">
        <property type="protein sequence ID" value="OXR43619"/>
        <property type="gene ID" value="B7C42_04487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="119" mass="13136" checksum="4FAB5D9C69803C06" modified="2017-10-25" version="1">MPLIDVTCSSHVSDESKRRLVAELPHIVSVAVACAAEPYDGCLQPGDVLVRCRSAEPGDRFDIDVLIEVKSKWFEDRAADRDRRAAHIRDEVARILPAGHLVGVYLSLPVTAWAQTDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4B6</accession>
    <name>A0A231H4B6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43632">
        <property type="protein sequence ID" value="OXR43632"/>
        <property type="gene ID" value="B7C42_04500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="33479" checksum="35AE48EFF1CD229E" modified="2017-10-25" version="1">MSPNGSDRTPPPERRATIIDRVTDKAASRTAVLVCQGRAVADGRLAVGRFSDPIAAQLLHDDERAAVRRARAPRPPGGWRERLEFEMLTATAAVLATRTVVIDEAIREASAAQLVLLGAGLDGRAWRTSEPAAEVFEVDHPASQRDKRARVGALVPAAKSLTYVPVEFGRDDLGARLAEAGHRADATTTWVWEGVLPYLTQPQVESTLAVVAARSANGSRLIATYPTPNRFAALGRAGMRLYSKLAGARDPLADEPHVSAWWPAEMAALTTRYGLTVTADVELIEAARRLGVPARQSRAYGLGRALIADRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4J5</accession>
    <name>A0A231H4J5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1713 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402602.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A231H4J5"/>
    <dbReference type="EnsemblBacteria" id="OXR43781">
        <property type="protein sequence ID" value="OXR43781"/>
        <property type="gene ID" value="B7C42_04016"/>
    </dbReference>
    <dbReference type="GeneID" id="64259567"/>
    <dbReference type="GeneID" id="66969437"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="COX24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1713" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="33" mass="4145" checksum="8156A587F16291F5" modified="2017-10-25" version="1">MGSVIKKRRKRMSKKKHRKLLRRTRVQRRKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H561</accession>
    <name>A0A231H561_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43970">
        <property type="protein sequence ID" value="OXR43970"/>
        <property type="gene ID" value="B7C42_04209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="27306" checksum="75D7120C150DB0F7" modified="2017-10-25" version="1">MSSVIERRLLVNYRIDPEAAARLVPRPMRPQLVDGRAVAGICLVRLGQFRPSWLPGWVGMRTENAAHRIAVEWDGPQGLSTGVYIPRRDSGSAINVLAGGRLFPGEHSSARFDVRETAQDLHVAFTSRDKTVSVSVDVRTAERFQGSELFADLAQASDFFRRGSAGFSPTHSGRCLDGLELHTDAWQVEPVDIHSVRSTVFDDRDRFPPGSAVLDCALLMRQVPATWRPLPPLRVDAGSTSAGNSAHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5C4</accession>
    <name>A0A231H5C4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pnbA_1</name>
        <name evidence="3" type="ORF">B7C42_04221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43982">
        <property type="protein sequence ID" value="OXR43982"/>
        <property type="gene ID" value="B7C42_04221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="506" mass="54789" checksum="A2D2013F0F338316" modified="2017-10-25" version="1">MVDITTADGVVRGLRRRRIAQWRSIPFAAPPVGDLRFRAPQPVESWSGVRMATEYGFAAMQQRDGARIGPRGPQPTSEDCLTLNVTAPLAPATAPRPVMVFIHGGGYVLGTSALRLYSGARLALRGDVIVVSFNYRLGAFGYVDFSEFSTATRPFESNLGLRDQVAALRWVQRNIAAFGGDPNNVTIFGESAGAHAVVSLLATPAAAGLFHRGIAQSAPADWSLTAEEARIFARRCVENLGVDNIDATSGEAAEALTSAGANDIRKAADRAIADVLWRQPGSFPAAPVVDGDFLPMDPIDAIAAGRAHAVPLIIGTNRDEATLFKRWDRSLPTTPGQLHVALSRCGDADLEKRVVAAYPGYPSRRAAVRMGGDFVFWRPTVEVLEGHSRHAPTYAYRLDYAPRAVQLAGFGATHAFDLIPVFGGVDSAIGRGLTVAGGYRDFLAVQREFQDNWLSFARKGEPLPSWPQYTEQRRSTRIIDSPARVEVDPDRAKRLAWHGVRVPALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5I0</accession>
    <name>A0A231H5I0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosyl-[dinitrogen reductase] glycohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">draG_1</name>
        <name evidence="1" type="ORF">B7C42_03713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.24" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44154">
        <property type="protein sequence ID" value="OXR44154"/>
        <property type="gene ID" value="B7C42_03713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047407">
        <property type="term" value="F:ADP-ribosyl-[dinitrogen reductase] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="32617" checksum="4B1E5C38153DCB51" modified="2017-10-25" version="1">MPVERDAGLRDRAQGVLLGTAAGDALGAGYEFTHPAADSVIEMRGGGSLRWEPGEWTDDTAMAVGVALAAAEHGALHHPAGLDAVARQFVRWWDSRPKDVGYQTSQVLQWRSADAADMRRRSFELDGLTGGNGSLMRTAPVALCYLDDPDNCARAARAVSELTHSDVRAGEACVLWTWAIRHAVLYGDYDGVRGGLAFVDADFWAALLDEAESGTPADFPKNGWVVHALQTAWWAITHTESLPAALEAAVRAGGDTDTTAAIAGGLLGARWGASAIPPQWVALLHGYPRLRGDDLVALTRRIVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5S2</accession>
    <name>A0A231H5S2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44185">
        <property type="protein sequence ID" value="OXR44185"/>
        <property type="gene ID" value="B7C42_03745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="AAA_16" evidence="5">
        <location>
            <begin position="144"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="726"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="954"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1287"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1346" mass="144215" checksum="AFE5EF1D7B8B8B79" modified="2017-10-25" version="1">MESAPPRRGRPRPSPRTLFSQRFAELFAAAGNPTLRRVAAAADARMRATRGPGQKSPVSVQRLSDWKAGRNVPARFESLLPVLLTLIDEARKSSAPVAPALLDLHQWQQLWTGSNDWDPNSEAADLLCPYLGLASYRPEDADVFFGRSRHTADLLDLIRTTADGDGGLVVLVGASGAGKSSLLHAGLIPALADSEPEWAMVTMTPGADPMGALLTAVGSPAAAPAGPEPRAEAMSPASERPGESPAPEPAAAGADSPAMTTVPVEVARWAAGGRRILVVDQLEELFTLCRDERRRVEFLAVLEHLAVRGPQDPVPVVTAIRADFYARCLDEPVLEDALKHRSYLLGPMRLDELAEAIIRPADIAGYKLESGLEELVISELCGLGGGGDRRSYDPGALPLVSHVMEAVWERRDGSRLTIEGYRAAGGVLGSVAATAEQAWNDLTDFQRAVGKQVLLGLVAVGDDSRDTRRKVSRAELLTRTVEAADAALDALARTRLVTLDADTAYLTHEIVLDAWPRLRSWIDDDRVGYLERQRLHTDAADWAEHDRDPSLLYRGARLTTMRDHARNAALGPVAAEFLAASESARQRAQRRVTARRSALAVLAVVSLALAGVAFVQSHNASHERDNAVFRSVLAEADRVEGSDPSLSAQLDLVAYRMNRDDPGARARMVNTQTMPLAARLPGHDGWVYSVAVSPDGTTMASSGGDNTIRLWDISDHSHPHSLGAPITGHTDFVGELAFGREGSVLASKSADHTVRLWDVRDPGRPAQLGREIPAGYARGLTMSADGATLLTAGDSGGIDAFDISHPDNPVTVGTIIPRPGAPGDSYEMVSFSADLHRALTLTFDGHTQIWQLDDARKPAVPQGNTSAEANSIALSPDGDTAAVAVNKTVELWNVSAPGRPVRAAAPIQGAKLTMYTPLAFRHDGRALADSDDKGAMRLWDIRDIDRPLPLVQPLSGAKGAISGAAFTPDGAGFAAAGQDGCVRLWSLPQQFAGDAWPHGRLAAVRGNRVAMIDGAAVEIWSLDDHTSAHRVGSIDVGNTSRRSVQVVISPDLRKLAVIRDFSGLELFDLGDGRTVRPIGRLPVDLRSAVGSAGTIDGMAFDNRSERVVVLARSESTTWFQLWNISDAGHLDPVSPRTRITGEEYPYLFGAVFGPNDDRLALAQHNGSVSLWDVTPREPHRLGEVRAGGAESGLQIAFDPGGETLVTAADDQTIRAWNVADPTHPRPLAPPSAGHSSMLRSVAFSPDGKTLVSADREAVRTWDFGKPDRPQGADHATVSTGETFAGVVGFLPDGKHLIGATADGTVHVWDLDPQHAVDRICSTTKSVLTDQVWREHLPQTRYRPPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Z6</accession>
    <name>A0A231H5Z6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="3">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">coaE</name>
        <name evidence="4" type="ORF">B7C42_03811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CoaE family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the UPF0157 (GrpB) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44250">
        <property type="protein sequence ID" value="OXR44250"/>
        <property type="gene ID" value="B7C42_03811"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="42745" checksum="09FF53F3660F3B16" modified="2017-10-25" version="1">MLRIGLTGGMGAGKSTVARLLVEHGAVLVDSDAIAREVVEPGTEGLAALVAAFGPDILAEDGSLNRPALAAVAFADEQSRTTLNSITHPLVGRRTTDLIAAAPADAVVVQDVPLLVENNLGAMMNLVVVVMADEQTRVHRLEQFRGVSRADALARIKAQASDDQRRAAADVLLDNNSDAEALAPQVRALWEQRLLPFEHNVRTRTPARSTGPVRLVEPDPQWPAQAQRLIGRLWLACGGDARRIDHIGSTAVPGLAAKDVVDIQITVADLATADALRDRLAGAGFPRIDSVTGDNPKPTSQDPAGTDAELWAKRLHGNADPGRLANVHVRVDGSPGQRFALDFRDWLRADAEARAEYLEIKRRGEAEATGTVGDEAVEAYLSVKEPWFDKVYERVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H604</accession>
    <name>A0A231H604_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042309.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44268">
        <property type="protein sequence ID" value="OXR44268"/>
        <property type="gene ID" value="B7C42_03829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="13010" checksum="2928E07D2B2E23E0" modified="2017-10-25" version="1">MSEHAGDPSALSESADQETVRELADIPAVEVISRAAVMLMSSAAEKLGLADEDPDSSPRRDLDEARRVITALAGLVTASVEYLGPHAGPIREGLQSLQRAFRESSAHPDAPGAGPGEKYTGPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H657</accession>
    <name>A0A231H657_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner membrane protein YohD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yohD</name>
        <name evidence="4" type="ORF">B7C42_03746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44186">
        <property type="protein sequence ID" value="OXR44186"/>
        <property type="gene ID" value="B7C42_03746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="22929" checksum="5D9A7645094B3B42" modified="2017-10-25" version="1">MHRILDIAPVWVYLTVGLLVFAEDAIFVGFVIPGETAAVLGGVAASQGHVLLWAMILLVVAAAIIGDSVGYEVGKHFGSRLLAASYLDKHRGRLDNAQQFLARRGGWAVFLGRFTAFFRAVMPALVGASRMPYPKFLSFNAIGGIVWGTTFVVLGYVAGNSYEKVAKTVGRDMAIAVVVIVVLALIVWKLRERRQEKKIESEYHATHDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H679</accession>
    <name>A0A231H679_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">menA_1</name>
        <name evidence="5" type="ORF">B7C42_03899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44338">
        <property type="protein sequence ID" value="OXR44338"/>
        <property type="gene ID" value="B7C42_03899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="36007" checksum="45E826CB517D13AF" modified="2017-10-25" version="1">MTDNRVSLAAQWTEIFTADGSAPPEKLSVQSWLRYSLIIRRVEFLPLTVTVPLVPALLMARTMRELLSLDMLLATIVVVVSIQIGNMANCLADRRMDAIYKTRLSRAVYGLGVGRVIRQIVIAMVIVGVAEGWLTYRTGHLDLLLIGGLWAVLGMGYSLPPLHLNGRGIWQLPVLHAVYFVLPGLFVLRAFEGSLSWAAIAAICGFSLTNIGIIVISHAEDFPEDELYSVMTYVRTLGLTRAVGLGVAMLTLGAIVVTASIVVLAGPVWGLVPYLAACLFAVRFMARTARAVRGKPVDEGVAVLRASSKLAPLHTLLVGWTTVVVAAFAFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6B9</accession>
    <name>A0A231H6B9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44464">
        <property type="protein sequence ID" value="OXR44464"/>
        <property type="gene ID" value="B7C42_03253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18739" checksum="85E64DB838B19688" modified="2017-10-25" version="1">MTRMTIVVGAVAMIALIELVGLSNQREMVPILVGVPVLGALALLLWSLVERSRAQDRADADDHDFENGPAEMLSRWHARAQMLATRADGTRADWDRYLRPLLAKEFELSSGHRIAKNRKATEAAGRLQFGPELWRWVDPANSSPRDQTTRAPGRDALDEILRRLQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6H6</accession>
    <name>A0A231H6H6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_16</name>
        <name evidence="1" type="ORF">B7C42_03427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44633">
        <property type="protein sequence ID" value="OXR44633"/>
        <property type="gene ID" value="B7C42_03427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="25275" checksum="CA5C8AC3F09DDAB0" modified="2017-10-25" version="1">MSDNTIAVVTGAGSGIGRAITLALAARGDRVVAADLDLDAAKRTAEQQPDRIVAMKVDIADAAQVQALRDQVHAEVGVPNILVNAAGWDRTDTFLNATPEFAQKVVAINYLGPVHMCSAFLPGMVEAGGGRVVNLASDAGRVGSSGETIYAGAKGGVIALTKSLAREMARYSITVNCVCPGPTDTPLFQAQDEKLKQALIQAIPFRRLARPEEVAAPALFFASPDASFITGQVLSVSGGLTMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6X6</accession>
    <name>A0A231H6X6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44595">
        <property type="protein sequence ID" value="OXR44595"/>
        <property type="gene ID" value="B7C42_03385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="34018" checksum="4FE226F3433887A9" modified="2017-10-25" version="1">MSVELVEVVRSGFRECVHRGSVVIIEPDGEPSLARGEVHLPIFPRSTNKPMQAITLLRNGFEPIDEAELAIATASHFGEPDHLALVRRLLERFGFDENSLGCPPDLPMGEQARAEALAGRDRHSAPRKIYMNCSGKHAAMLATCVINGWPVTGYLDPAHPLQQAVTATIADITGEPETDLGIDGCGLPIVPVSLINLARAYARLATAAPGSPERRVADAIRHHPRVISGTDAPDLETMRATPGLVCKIGADGVHAGALPDGRAFAYKIDDGHDRARMPLTQAILQRMGVEWTEAHTALAGPPVLGGGARVGIIRAIPGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7F6</accession>
    <name>A0A231H7F6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">paeR7IM_1</name>
        <name evidence="6" type="ORF">B7C42_02765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234278">
        <property type="entry name" value="M.Nce30759ORF2765P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44811">
        <property type="protein sequence ID" value="OXR44811"/>
        <property type="gene ID" value="B7C42_02765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="RM_methylase_Eco57I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Eco57I" evidence="5">
        <location>
            <begin position="168"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="694" mass="74829" checksum="50E44B6D49320A0A" modified="2017-10-25" version="1">MRGGREQPAADRRAGREPGGGGARKRHGRHYTPPRLAAFLAERMLAHVRPGRELSVLDPACGDGELLSAVARVAAQRFPGTSLHLVGYDLNAAAVDEAQARGVAWNNRFGSSSQVWPEKGTAGSRVADGVGASFDAVSGADAAPPNRVVIDWRVGDYLCAATELADAHFDAVITNPPYVRTQQLGGATAQMLSKQFGLSGRIDLTHPFVATIPRLLRPGGVLGLLCANRFLSTKAGANLRALLYAELTPVELYDLGDTRLFEAAVLPAVTIAVRGREKRTCRFVTAYESEREPTAETDLFDALVGPADSVVEHGGRRIAVETGTLWTGAHDSAGRVRNPEPGMAPSVASASGKSPSSERSMASGESPVGASRAGASRPAGGVPAHRSIWIGREHDAESGMAGTPVEGVDADVKCEDESLTSTFDPATPWRMSRPDTDAWLARIAAGTWRTFGEVARIRVGIKTNADRIFISDRWEDRPCCPEPELLHGLLTHHDLVPWRIARAHDTRVLYPYDASCTCRTPIDLNEYPRAAAYLAQHKDTLAARDYLTGTGREWFEIWVPQRPHLWCRPKVVFPDISVAPRFALDRSGAVVNGDCYWMSLADIGDERLAYLLMGVANSTLGLRFYDAVCGNRLYAGRRRWITQYVTRLPLPDPNTGAGHKLTDLAGDLANGGAEPDAALLDRRVAAAFGLGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7H4</accession>
    <name>A0A231H7H4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative endopeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44707">
        <property type="protein sequence ID" value="OXR44707"/>
        <property type="gene ID" value="B7C42_03501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012014207" evidence="2">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="79"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="19666" checksum="7DF88BAB71005AA0" modified="2017-10-25" version="1">MAGTEAGRCTRRLRRKAWSTAASLVVLLGAAGTMVATAGPAHADSPFPVPVVPGISLPPQFTIPGLFPEITPAPPESMKSVGERALEAAETKIGSAYISGAAGPDAFDCSGLVQWAYRQVGVDLPRTSYDQLSAGTPVDLDTLQPGDLVSFYGGGHSALYAGDGTVVHAATSGEGVIRSAIGQMPVTGARRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7V7</accession>
    <name>A0A231H7V7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inosose isomerase</fullName>
            <ecNumber evidence="2">5.3.99.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolI</name>
        <name evidence="2" type="ORF">B7C42_02791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.11" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44837">
        <property type="protein sequence ID" value="OXR44837"/>
        <property type="gene ID" value="B7C42_02791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="280" mass="30289" checksum="255208F8834C0F18" modified="2017-10-25" version="1">MTLSDLTLRNADLGTRCAAAAAAGFTGIGLSVEHYRAALKDSSTPADIAAVVAGHGLAVNEVELAAHWADPAAYSKDELESDRIVVRMAAELGATRIHTTMAQHFPFETLARGLRELCDRAADSGAIVALEYMPYAAIDSATSAWRLLEASGADNAGLLIDAWHWQRAHTADESDSALRTIPAERVAAIQLCDTLPEPLPDLRREALHHRRLPGHGTAALIPMLRRLARHGVRAPIAVEVVSDELDAQDPYVTARQAYVSSRRVLRDSGWPDSTPRRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H824</accession>
    <name>A0A231H824_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45163">
        <property type="protein sequence ID" value="OXR45163"/>
        <property type="gene ID" value="B7C42_03121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="8761" checksum="1B428E294287BD06" modified="2017-10-25" version="1">MFSLPMMFAATGWPLYLALHSGLPPLMDYLAIVGMILLIVAANVAIVNLAVGWRSVTGRRAADTGGDTARATGDDPRWSVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H849</accession>
    <name>A0A231H849_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-(Hydroxymethyl)mycothiol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.306</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.306" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784239.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44962">
        <property type="protein sequence ID" value="OXR44962"/>
        <property type="gene ID" value="B7C42_02919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050607">
        <property type="term" value="F:mycothiol-dependent formaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="38122" checksum="B8C8673D2B7B0069" modified="2017-10-25" version="1">MSQKVRGVIARSVGAPVEIVDIVIPDPGPHDVVVRVQACGVCHTDLTYREGGINDEFPFLLGHEAAGVVDTVGDAVTHVQPGDHVVLNWRAVCGQCRACKRGKPWYCFDTHNASKPMTLADGTELTPALGIGAFADKTLVHEGQCTVIDPETDPAVAGLLGCGVMAGLGAAINTGGVSYGDSVAVIGCGGVGDAAIAGARLAGATTIIAIDRDPRKLEWAKELGATHTLEAGDDVVERVQELTGGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPLIDFFSHGGSLKSSWYGDCLPERDFPMLLDLYRQGRLPLERFVSERVALDQVEQAFTTMHHGDVLRSVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Q3</accession>
    <name>A0A231H8Q3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45403">
        <property type="protein sequence ID" value="OXR45403"/>
        <property type="gene ID" value="B7C42_02528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="15344" checksum="35EEB4D39DBBAABC" modified="2017-10-25" version="1">MQDLRPVGIYREMYRKDKPELRPLSESYTTRIIGDRDRIADYMQAGTPVFDVMEDVVDMVDGREWIRSGPTLVSDGEWIWRLDSIHYLRNYSLDMPQEFMDHVRRQNYQPPETIDVTDARYDTAIAAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8V0</accession>
    <name>A0A231H8V0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45117">
        <property type="protein sequence ID" value="OXR45117"/>
        <property type="gene ID" value="B7C42_03074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="37787" checksum="34684E8736889C16" modified="2017-10-25" version="1">MARFARPRLPKVFGFLRNRYLRLGLIASATVLILLLGSSALTQARLGDKTIHAEFAQAAGLRPGATVDVSGIEVGAVRTVRLDGAKVVADLKVRGDLRLGPDARAAIKMSTILGRLHVDLVPGNGKGLPGNRIRLDHTSVPYNLSKVIQDPQYKASFERIERIDPQKLREALDTMNQQMGDSPQLAVQALDSIGSLAKVINDRRDEVDTLLKGMDQVSQLVADNQNSVLMLLTRGEAIGQAVQKRRQLLKNLLDNVAALSKLLQDMGLENNNQFGPMIRDLNTMSEGLEKNKTNLDRLYEIMPVTLRQFNNVLGNGPYGDVYVPWGLFPDNWICFAQVVQGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8W2</accession>
    <name>A0A231H8W2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensory transduction protein regX3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">regX3_1</name>
        <name evidence="6" type="ORF">B7C42_02385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513615.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45260">
        <property type="protein sequence ID" value="OXR45260"/>
        <property type="gene ID" value="B7C42_02385"/>
    </dbReference>
    <dbReference type="GeneID" id="66719190"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="24646" checksum="DCB5D6A37736E648" modified="2017-10-25" version="1">MTAVLLAEDDEAIAAPLSRALGREGYSVTVESFGPAVLRRALEGEHDLLILDLGLPGMDGLEVCRQVRARGADLAVLMLTARTDEVDFVVGLDAGADDYVGKPFRLAELLARVRALLRRSGIGDEAVEIGGVRLEPAARRVLVNGHEVNLANKEYELLKVLIDRAGQVVPRETILREVWGDADLRGSKTLDMHMSWLRRKIGDEGPVAERRIVTVRGVGFRFNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H961</accession>
    <name>A0A231H961_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tsaE</name>
        <name evidence="7" type="ORF">B7C42_02514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45389">
        <property type="protein sequence ID" value="OXR45389"/>
        <property type="gene ID" value="B7C42_02514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17353" checksum="11F406E732D0B313" modified="2017-10-25" version="1">MAERRDGAPEDQGEAERRELPTVADTEALGRELAAELRPGDLVVLDGPLGAGKTALTRGIAAGLGVEGRVSSPTFIIARQHRAGAAPGSIPLVHVDAYRLGGDLDELDALDLDADLHESVVVVEWGLGVVEHLADRHLRVRLHREAESETRTATWEWVGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H981</accession>
    <name>A0A231H981_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoadipate enol-lactonase 2</fullName>
            <ecNumber evidence="2">3.1.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">catD_1</name>
        <name evidence="2" type="ORF">B7C42_02515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.24" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042001.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45390">
        <property type="protein sequence ID" value="OXR45390"/>
        <property type="gene ID" value="B7C42_02515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="92"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="40268" checksum="D6F39436ED9DF857" modified="2017-10-25" version="1">MEPERAHRLRNARRVRYTLLRGGVASASVLGALAGAQALRRMGAAVAWPARGDDLRDEDFTLLDRDPAHRVVADDGVPLAARVVGAENPSATVVFVHGFCNSMHSFHFQRRDLARQWGSQVRMVFFDLRGHGSSGTPSSASCTVAQLGRDLLRVIEECAPDGPLVLVGHSMGGMAILAAAAREPELFERRVLASALLSTTAAGVTRAGAAQLLRSPAIDGFRVLVHTSPALVQAGRVTARRLITPVLHVSSFHGDVSPTLSRFTTSMIDRTPVETIVKFLEALQVHDESAALPVLAPRPALVVGGDHDLIIPFRNSRELAARLPDADLIRVTDAAHMVHLQYPELINAALERLLLRAGVFGGSSVEFGAGREASNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H983</accession>
    <name>A0A231H983_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">glmM</name>
        <name evidence="11" type="ORF">B7C42_02543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776596.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45418">
        <property type="protein sequence ID" value="OXR45418"/>
        <property type="gene ID" value="B7C42_02543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="169"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="268"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="384"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR45418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="455" mass="46935" checksum="538507BC8619B958" modified="2017-10-25" version="1">MGRLFGTDGVRGLANDSLSPELALQISAAAAQVLGRGRSRAVAVVGRDPRASGEMLEAAVTAGLTAAGMSVLSVGVLPTPAVAYLTAAYDACLGVMISASHNAMPDNGIKIFAAGGHKLDDSVEDKIEELVRAKGFVRPTGAGIGRVLSLSGVDGHVEDHYSLAGTHERYVEHLVEATGRDLSGITVVVDCAHGAASDVGPAAYREAGARVVAINAEPNGLNINERCGSTHLEHIQRAVLEHGADLGLAHDGDADRCLAVDGSGAVVDGDAIMAILALAMHESGELVQDTLVATVMSNLGLHIALRDAGITVRTTAVGDRYVLEELRRGGYSLGGEQSGHLVFPRYGTTGDGLLTGLKLMARMVETGRGLADLASVMTTVPQVLVNVPVADKAAVAAAPEVREAVAEAERALGDNGRVLLRPSGTEQLIRVMVEATDSHRAKQLADDLAKCVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9F4</accession>
    <name>A0A231H9F4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator YurK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yurK</name>
        <name evidence="3" type="ORF">B7C42_02585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041985.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45460">
        <property type="protein sequence ID" value="OXR45460"/>
        <property type="gene ID" value="B7C42_02585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="30523" checksum="7BC3C7A6A40E2386" modified="2017-10-25" version="1">MAAGPRYQRIADVLRDAIRDGTYKPGDRLPSHNELADQMHVSITTARNAIQVLVAENLLFTATSRGTIVRSQEVLESVVTNHIRRDRPTSAHDIFSEIARAAGREPAKQFSARMEPAGTEVAHWLGVPKDSWVVSRTVVQYLDNEPWSWEVSYYPRDLAELTGIDSPHDIPEGTTRRLAARGYPETAHRDTVVARPASADEAAVLGVGAGTMLLDHLRIGASSTRIMRVTRQRSLAARNRLAYELGDDEGTALIRKTLGAPHPPGNSHSFGNSLVPGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9G8</accession>
    <name>A0A231H9G8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">malE</name>
        <name evidence="2" type="ORF">B7C42_01955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784071.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45663">
        <property type="protein sequence ID" value="OXR45663"/>
        <property type="gene ID" value="B7C42_01955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011301475" evidence="1">
        <location>
            <begin position="25"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="440" mass="48595" checksum="88D3E23C37700C50" modified="2017-10-25" version="1">MASSRRFDRRTLLRGAAAAGAAVAASSITGCGDHDDDALTFFFQAKPDEAKVRLTIIDEFRKLHPDIKIRTQMSGPDPQTQILTYCAGGKCPDVLMSWDLSYSFLAERGIFENLDTILDKDPAYAAELKKDSSTALYNTFRYKNAQHALPEQWAGIFLYYNKKLFADAKLAPPPARWEDAWSFDEFLDAARALTRRDSSGDVVQWGFVDPWTVYYSASCFGMNNGVEWFSPSIDPTRTNIDDDAFIEGVQFYTDLSTRHRVMPRIEFQQSLSSSDMFAQGKAAMALSGHWMYSAYTGQPDLDFDVTVLPVGPRGTAARSDIGTTGLSIAADSPRKEQAWEFVKFATGPVGQAVIAKSGLFVPALKSALASDGFAQAHERVHNLEVFHGGDHANNLPVTPAWPRVDAVIEQGYDHVFRGAASAEWFKRGLAGQINDLLEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9M2</accession>
    <name>A0A231H9M2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Thermophilic serine proteinase</fullName>
            <ecNumber evidence="16">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B7C42_02561</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="16"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45436">
        <property type="protein sequence ID" value="OXR45436"/>
        <property type="gene ID" value="B7C42_02561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371105" evidence="14">
        <location>
            <begin position="31"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="15">
        <location>
            <begin position="93"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR45436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="471" mass="48517" checksum="EECB5F7B8CB9425D" modified="2017-10-25" version="1">MNPKMFGRRVIRVAAVVAVLGLSASTGAGAAIADKPVVNPGALPSGGNPAPPDATEQPANSPCASTSTGGDGPTVPTAQRSLELDKAWQFSSGAGQLVAVIDTGVMRHPRLPGIIPGGDYVSAGDGTDDCDAHGTFVAGIIAATRLSTQGFSGVAPQAQILSIRQTSSYFQKKGAGRDKGPDAMPEGYGTTHTLAQAVRRAADMGATVINMSEVACQAGVIPDDDLGAAVHYAAVERNVVVVTAAGNNDKCKGTNPVIDPLDPSADPWTKVDMNVSPARWDDYVLSVGSIDDNGQPSKFTVPGPWVGVAAPGENLTSLDPHWDDPRSKGTAVAKVDQQGKAEPISGTSFASPYVAGVAALVRARFPELSALDVIKRIEATAHAPAEGWNPYVGYGAVDPVAALTAQVPNSLPPKRPSAAESRQLPVPTTPPAPDHTSRNVALIGTGVIGVLAVLGYLASFPLRRRFRDRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9U9</accession>
    <name>A0A231H9U9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45582">
        <property type="protein sequence ID" value="OXR45582"/>
        <property type="gene ID" value="B7C42_01874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="180" mass="19215" checksum="FFCE763BD69D3302" modified="2017-10-25" version="1">MPHLAGPATVWMFLVRSRIPDSDRCVRYFDALSASGVGRNGAIGVNDEIILERPAFAVGLALIIDPTRSVDQRAPGLVLESGAPRAVSACADEDLRCGSRAQFVDRVDDLVEFTFLDPAGGVVDAAGHRRDNGAELVRSVAYGVAVTDRDIGDAVTNLDDGAAEFVTEDLREFGTGQRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA25</accession>
    <name>A0A231HA25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783978.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45596">
        <property type="protein sequence ID" value="OXR45596"/>
        <property type="gene ID" value="B7C42_01888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18788" checksum="C06DE39EB2DF7311" modified="2017-10-25" version="1">MENKLSLAQMEELLAIHEMAEFNVDLDATMATLVDNPVYELPALGWRIEGQEAVRETYRRLLHGGDVYNLWADKRVHATSPTSLAREAYVYIDTPDGRVTGQYFVAMDFAGDKIAGERMYMDTTFAKAMTDILGPDFGDIPGVSRLADTVPTPRPRLDRAAAHAADSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAE6</accession>
    <name>A0A231HAE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atsA_2</name>
        <name evidence="5" type="ORF">B7C42_02226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45933">
        <property type="protein sequence ID" value="OXR45933"/>
        <property type="gene ID" value="B7C42_02226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="783" mass="87534" checksum="1BF31BB48A93A9D9" modified="2017-10-25" version="1">MAEKFEGHIALDIRDSVADWKPFAEPTAPRGAPNVLYLVWDDIGIATWDCYGGLVEMPNMQRIADRGIQFTQFHTTALCSPTRASLLTGRNPTSVGMATIEEFTDGFPSMSGRIPDDTALCSEVLTERGWNTYAVGKWHMTPLEENNLAASKRHWPLGRGFERFYGFLGGEADQWYPNLVYDNHPVTPPYSPEDGYHLSKDLADKSIEFIRDAKVIAPDKPWFMYLCPGCGHAPHHVPREWADKYRGRFDMGYEKYREIVLENQKRMGLVPEDTELSPMNPYADATGSNGEPWPLQDTVRAWDSLSEDEKRLFRRQAEVFAGFLSYTDAQIGRLLDYLEESGQLDNTIIVTLSDNGASGEGGPNGSANEMKFFNGYIDTIEDSLAKLDELGSPTTYNHYSIGWAMAFNTPYKLYKRYASHEGGIADACLLSWPAGIAARGELRHQYLNVCDVTPTIYELLGITPPETVKNVTQRPLEGVSFRALLDDPDADTGKHTQFYSMLGTRGIWHRGWFADTVHAACPSGWGHFDSDRWELFHIEEDRSQMHDLAGDRPEKLEELKALWFAEAEKYNGLPLYDLDIVSVMLRDRPTYAKTRDSAVYYPGIAEVGPGAALEIRGRSFALLAETTITSPDAEGVLFAHGGRLGGHTLFLQDGHLYYVYNFLGEEEQVMVSDRPVPVGDHILGMRYERKGTRPDNFTPTGEAVLYIDENPVGSLDDMRTQPTVFSGVGEGVRIGRDGGRSVSPRYHAPFPFTGGIMHQVVEDVSGKPYLDLEMAAAAAFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAK2</accession>
    <name>A0A231HAK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="6">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_02182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45890">
        <property type="protein sequence ID" value="OXR45890"/>
        <property type="gene ID" value="B7C42_02182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="508" mass="56093" checksum="1B9DABA535B61647" modified="2017-10-25" version="1">MNTGRYTVLDVAIVGAGFAGIGAAIRLRQRGITNIALFERDRRVGGTWRDNTYPGAACDIPSRLYSYSFAPNPDWSQTYSGSAEILGYIDAMVERFALGDSIRFGHTVSGLTYDEAAGEWEIAFAAGRAPVRARSVVVASGPLANASLPDIPGRDSYEGHMIHSARWDHDYDFTGKKVAVVGTGASAVQIVPELVERAGSVKVFQRTPGWVLPRINRHTTGLTRQLYRHLPRTEQLARQAWFWGHESVALGVVWNTPLTRIVESVALAHLHSQVRDPWLRRQLTPDFRAGCKRLLTSSDYYPALQRDNCTLVTWPIAGMSPAGIRTAEGIEHRFDCIVFATGFEVSKAGAPIPITGRGGRVLDDEWRRGAYAYKSVTVAGYPNLFFTFGPNSGPGHNSALVYMEAQIDYLAAAIGMLLERNLHSLEVRRDRQDRYNHRLQRRLRATTWNSGCRSWYLTEDGFNATMFPGFGSQFTGQLATVDPRDYVLIPGRGGGRAPVADRAVTSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAK5</accession>
    <name>A0A231HAK5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45881">
        <property type="protein sequence ID" value="OXR45881"/>
        <property type="gene ID" value="B7C42_02173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="30142" checksum="7E8802EC557AC5D9" modified="2017-10-25" version="1">MTYPPGPGPYGYGPQQPHDAGWGRDPNQPGSGWDAAPGGWETPAWDQQMPAPNWGQPAPGGYPTPPPPKNNTGLIVGIVFGVIALLVIAGGIVVVATRDSGGDNQAAGTSTPALVPATTDPRTTTAAPTTSASPGTSSHLSYQEYGHDWNFKAGDVELHADWVEGRDHPSCADIEVGGKLTSLGCQYAAEMVYKAEGGSLMLTQFIVGMSSSEKAAAAPDAYTDDDLTLRPGTYISNFATGKWKDDAEKQFLVITFATATGSVDENTVKKYLKYRHEDILGALAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAR1</accession>
    <name>A0A231HAR1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">icaR_1</name>
        <name evidence="5" type="ORF">B7C42_02253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45960">
        <property type="protein sequence ID" value="OXR45960"/>
        <property type="gene ID" value="B7C42_02253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="23246" checksum="5AB1AEF2C782A7D2" modified="2017-10-25" version="1">MPDPASDRTLPLRERKRLRTRRALADAALRLFTERGFDATTLDELVDEAEVSRSTFFRTYPAKEAAAIEAEAELWSAYLAALANRPLTGVVLDGMRETLTAAVADLEPEWDRRYVATRRLIRTAPALLAYVEYHRHGVKADAVTILADRLELPADDLRLHVLAELVTSAWSVAGREWVRADGRGGRDALTDRVREAFAAVPAGLALRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAU0</accession>
    <name>A0A231HAU0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylate/hydroxypyruvate reductase A</fullName>
            <ecNumber evidence="2">1.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ghrA</name>
        <name evidence="2" type="ORF">B7C42_02283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.79" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45990">
        <property type="protein sequence ID" value="OXR45990"/>
        <property type="gene ID" value="B7C42_02283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="102"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="31793" checksum="A9858B92DB298D0E" modified="2017-10-25" version="1">MAVTVLVPHEIGVSALAHLDGVSAVHYRHGVLPPGAEAARVLIPDFPAGAGTVALAHRLPELGLVQLLTSTAEGWVGALPEGVLLSHARGAHGDGVAEWVLGALIALYRDFAVFARARQERRWTTRPTDTLYGKRVLIVGAGDLAHALTRALTPFRTSVTLVARTARAGVRPVGELPALLPHHDIVVLAVPATARTRRLADARMLARMPDGAILVNVSAGPVVDTEALVAELSSQRLRAALDVTDPEPLPPDHPLWGAPGLFLTPHVAGTGSHSTSRAYAVAAAQIERFLTGRIPDNLVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAW0</accession>
    <name>A0A231HAW0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782184.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45857">
        <property type="protein sequence ID" value="OXR45857"/>
        <property type="gene ID" value="B7C42_02149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="100" mass="11424" checksum="030338AD8F3FFE98" modified="2017-10-25" version="1">MQMMVFSTPREGMDDEYNTWYTEVHIPELLQIEGIRSCSRYRAPQLEGQGAAHRYLAVYEIDGDAEAVFKQLRANSAEGRSTLSPAIDPRATQITFWEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBD4</accession>
    <name>A0A231HBD4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46122">
        <property type="protein sequence ID" value="OXR46122"/>
        <property type="gene ID" value="B7C42_01087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="246" mass="26976" checksum="D18545D1BF65B058" modified="2017-10-25" version="1">MTGTVGPVTTLAITNTLADGFSVHKLLDPMYLLTDTWMSNAVLPAILVIVFIETGLLFPILPGDSLLFTGGLLAAVEHPPVSIWVLVPAVAVTAIAGDQCAYWIGRAIGPALFHKEDGRFFKQRYITETHAFFEKYGPKTIILARFVPIVRTFMPVLAGVSKMDYRKFLTFDIIGGILWAGGITVLGYFLGNVGFIRDHVEAIFLLIVFVSILPAIISVAKKLRNHEPVLEIEEPTMSVPTNEPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBV7</accession>
    <name>A0A231HBV7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46361">
        <property type="protein sequence ID" value="OXR46361"/>
        <property type="gene ID" value="B7C42_01327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="81" mass="8755" checksum="ADD33BEE4894DE9D" modified="2017-10-25" version="1">MGQRERIDTMADAAIAAIAHMLGTEPESVSTTLPFTDLGLTSAQLARLTGVLEDALGMEISLTDLYDNPDIERLVDHLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC41</accession>
    <name>A0A231HC41_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46267">
        <property type="protein sequence ID" value="OXR46267"/>
        <property type="gene ID" value="B7C42_01233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="240" mass="25259" checksum="8B0A01B5384B7D9B" modified="2017-10-25" version="1">MCSGRGVGSLVDMGGETVSAPGSAGTGGAVGDRDLRVSDTEREHVGTLLQRAVGLGMLSLGEFSERMDTALAAKTRGELNAVLIDLPGIRLAGQPNPTQPTGPAPTWRWGAPGGRTEAETAIRPRLSGVTRKGPWQVPPSLYVNSYLSGVTLDFTQAVMSTQVVEIRVDDFCSSLTMILPGEATVDLNGVELIGSSANNKVRTGPPIGPLHIVVHGRSRFSSITAKHPFGVQWKKLMSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCB9</accession>
    <name>A0A231HCB9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">drrB_3</name>
        <name evidence="10" type="ORF">B7C42_01438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46469">
        <property type="protein sequence ID" value="OXR46469"/>
        <property type="gene ID" value="B7C42_01438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="280" mass="30494" checksum="97C23BF38FE218F2" modified="2017-10-25" version="1">MITAAIDTRRPTLAERAAIVVGDSLTIAKRNVIKIKRVPDVLIFSTLSPIMFVLLFAYIFGSAISVQGTSYREFLIAGIFAQTSVFGATFTGTSLAEDMQRGIIDRFRSLPMAPSAVLVGRTVADVAINVVSLVVMSVTGLLVGWRIHGSFLEAVLAYVLLLLFAYAISWIMAVVGLLVRAPEVFNNASFMVIFPLTFIANTFVPSEVLPTPLRVVAEWNPVSAVTQATRDLFGNTSPANPTPDVWSLQHPVATTLIWVVAILLIFVPLALRQFKRSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCH8</accession>
    <name>A0A231HCH8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator YvhJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yvhJ_1</name>
        <name evidence="5" type="ORF">B7C42_01499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46529">
        <property type="protein sequence ID" value="OXR46529"/>
        <property type="gene ID" value="B7C42_01499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="247"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="480" mass="51457" checksum="053DDD791D174F61" modified="2017-10-25" version="1">MVNGDDPQQYPRTRRVPPPAGPDGRRVPPPDRHGHDPRVPPGSGRPIPPGSGRPPHSGRPPGSGRPLPPGSGHPPGRPPIEPTQVIRRDGNNPPLAWSQVPSSPARPRGNPQPYEHGVEPGGEPPTHAPTQRPMPYREAPPPPPPARPRRAERPPREPRVPRARRKRHWGRWLLILLLIVILLPVAGAIYLDRSLHRVDALAAYPDRVAQTAGTNWLLTGSDTRVGLTPEQEQELSTGDSADAGGERSDTIMLVHIPKSGAPTVVSLPRDSYVSIPGVGKDKLNAAFSAGGPKLLVQTVENATGLRIDHFAEIGFGGFAGMVDSLGGIDMCLPDAIDDPKAGIDLPAGCQHLSGSQALGFVRTRATPRADLDRMNNQRLFLSALLEKATSAGTLVNPLKVWPLARDVASSLQVDNGDHIWDLGRLGWALHGKTIATTVPIGGFVDESGSGNVLLWDKDRAGRFFDALAHDQAVPDDLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCY0</accession>
    <name>A0A231HCY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46774">
        <property type="protein sequence ID" value="OXR46774"/>
        <property type="gene ID" value="B7C42_01752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012443801" evidence="1">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="6927" checksum="B964FBB9579D3A62" modified="2017-10-25" version="1">MSIIRFAFSAFAAAAVIGVGVGAAEAAAPAVAIDDTTTTDPSTGTGSAALLPSLLQALASGSAQSGGTTTTGANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD69</accession>
    <name>A0A231HD69_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46870">
        <property type="protein sequence ID" value="OXR46870"/>
        <property type="gene ID" value="B7C42_01849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="16350" checksum="D1BE84ECBBD48A89" modified="2017-10-25" version="1">MSELKSKLRADLTAAMKAKDTLRLSTLRMLLAAVQNAEVAGSEAKELSDAEVIAVLGKEAKKRNEAAVVYEQNGRGELAANERAEQEIIDEYLPTPLTEAEVADIADTAIADVAEQLGERPGMKQMGQVMKVATALAAGRADGSRISAAVKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDM5</accession>
    <name>A0A231HDM5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aliphatic sulfonates-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ssuA_4</name>
        <name evidence="3" type="ORF">B7C42_01843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041817.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46865">
        <property type="protein sequence ID" value="OXR46865"/>
        <property type="gene ID" value="B7C42_01843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011227826" evidence="1">
        <location>
            <begin position="30"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="54"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="36995" checksum="FA9B1DC2BC02BDB9" modified="2017-10-25" version="1">MSGRIRTALSVFAAGTAAAVLLTACGSGGSAHTENGVTSLRYLGWTDQVTIPELAENLGFFDGKIKLDYVGNTISGPQEIQTAATGQIDFGGAFAGAVAKLAGAGAPITAVVNYYGSDEKSFQGYYTLDNSPIRTAADLVGKKVGVNTLGGQNEADIHDALKKAGLSIDQIKSVQLVALPPPNIEQALRQGQIDAAALNGQFQQRAVANGGVRPIFTELDEYGGPINGGPYVFRNDFIAKNPDVVRAFTTGVAKAIEWERSTPREQVIAKFTEIINARHRAGEDTSTLKYWLSVGVPARYGQLSDGDFTRWQSWLEDTGAIDHKLDPSKFYTNKFNSLLQSSDASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE09</accession>
    <name>A0A231HE09_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chondramide synthase cmdD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cmdD_1</name>
        <name evidence="2" type="ORF">B7C42_00335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47213">
        <property type="protein sequence ID" value="OXR47213"/>
        <property type="gene ID" value="B7C42_00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="723"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="804" mass="85023" checksum="6760F7E7F1BD22C1" modified="2017-10-25" version="1">MRVLITGVTTPTGRAVARMLAAAGHDVVGADRVRHRYVDPRIEVHIADPGSAGAYRGLVDGCDVVLDVSNGPVAAVAAAAREAGARLVVLASPERENLARTAVAATGARALLVRPAPVAGRRTEGSRAVVRTLLNARGSQRIPLVHTDDVERFLVLAATSDRTGTVDLVAPELVSGSQARAMLRKAGLRIPPRVPGAGGVRLPALDPATAQGDWDFRYGWTGPEVVEDIVRGLVGRRPHGTSFRARRGAIPLTDYVIPARAKTSDGHPLEVAAPEGLEGEFDDRVDPRIPVHTATNTSEALPGPMSPLTIDLQAGAIRLANAAMGHMIALDGIALEHWTSRVTSVLGHHIFINASIGVLAADNMPGWDEDSIRRDVYGTIPPEVPLQPQGRPPMPTGLGSTWGTAKATGRVLATALRFGATTETINAASHREALSRIDIEKLSDAQLHARALLWRDRLNQSWAAASIGVMLVGAATAMHARGKDDPDVPIDVNRLESARPMLAVERLAAVCREEPAVHEAARAGDVALARSRSARFAQALDAELAVVGHRGPGECEFLNPTFGDRPELLVTAAARAAELPAPKRDAVPEPTARTARMAVGATVSRERVRDAVVRYTNCLRMAARELAARLVDRHELNNVDDAWFLTLDELLWAPADLKDRVARRREERVRLQAVRMPDLVVGRWEPQPISGALAVGESLTGTGVSAGVVEGTVKLVLSSDDDIEPGDILVASVTDTGHTAMFAYAAAVVTDIGGSASHAAIVAREFGIPCVVDTKTASTGLSDGQRVRVDGAAGTVTLLADAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEB1</accession>
    <name>A0A231HEB1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47037">
        <property type="protein sequence ID" value="OXR47037"/>
        <property type="gene ID" value="B7C42_00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15093" checksum="D9BE4EA4E1E51066" modified="2017-10-25" version="1">MNAIPGIPPMVTEETEPFWTGAAAGRLLAEHCPACGADSFPPRGICRRCRRRDPEFVEIVGPGTIYSFTVNYQRWLPDLEVPYAIVLVDFPGHPGVRIAGRLRGCDPEEVAIGMSVDIGFEPGPGGYAVPSFLAHEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEC9</accession>
    <name>A0A231HEC9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47182">
        <property type="protein sequence ID" value="OXR47182"/>
        <property type="gene ID" value="B7C42_00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20430" checksum="9042FF3E4B4B88D5" modified="2017-10-25" version="1">MSAASQPYGRDARTGPGGLRGRCAAAVDRGAVGTGAPGTAAELHAEIPDGHELLAACCGHLGDRADDHPVTRAARRLAELHLARRRSPVRAAEIDCRRREIVVHIDRWVSDRTAAAAHARSLGAAVDGLAAAQVRATVLLRDAETVDDERVRAAWFLVGSLADWWGELVEQHVGNARPRTRARRRPRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEJ7</accession>
    <name>A0A231HEJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47218">
        <property type="protein sequence ID" value="OXR47218"/>
        <property type="gene ID" value="B7C42_00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="15365" checksum="7AF4955782802D03" modified="2017-10-25" version="1">MARRARIEDVEELALAMPHVTVVRGSSGNPVYQVGGKSFIFFRTPRPDAVDPDTGERYPDVIVFWVPSESDKRALVQDPDSPFFTTAHFDGHLSVLLRGAHIGELDLDELREVVQDAWLSRASATRARRWLAEHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEU6</accession>
    <name>A0A231HEU6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47460">
        <property type="protein sequence ID" value="OXR47460"/>
        <property type="gene ID" value="B7C42_00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045684">
        <property type="entry name" value="DUF6191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19690">
        <property type="entry name" value="DUF6191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="95" mass="10152" checksum="92AF6B6B55998C86" modified="2017-10-25" version="1">MTLPGLALLIIAVAFAEVASRKMTGRAALPWMRESAGPSAAGIGFEQFDALFDAGKRHEFEERQTVLMHRENPGDGTPGAADVDLSSGRARLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEV2</accession>
    <name>A0A231HEV2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">metE_1</name>
        <name evidence="10" type="synonym">metE</name>
        <name evidence="13" type="ORF">B7C42_00595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47470">
        <property type="protein sequence ID" value="OXR47470"/>
        <property type="gene ID" value="B7C42_00595"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="11"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="431"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="436"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="436"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="520"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR47470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="756" mass="81709" checksum="45393A17A01B688B" modified="2017-10-25" version="1">MTVTTHNRFTATVLGLPRIGPRRELKRAVEGYWAGRIDAAELERVARQLRAQSWSAAQDSGLDAVPVGTFSFYDQMLDTAVMLGALPPRVAGIGDPLERYFAAARGAEGVEPLEMTKWFDTNYHYLVPEIGPDTRFALDPSALLAELREARELGIAARPVVIGPLTFLALSKGVDGVAPMDRLAELIPLYRDLLARLSDAGAAWVQIDEPVLVRDLSEAELGAVRTTYAALSDGDRRPNILVATYFGSPGPALGVLASTPIEGVALDFRSGTTVSEVAAVPALADKLVVAGVVDGRNIWRTDLGAALSELATLLGSVGALAVSTSSSLLHVPYSLDTETGLDPVLRSWLAFGAEKIDEVRVLAHAVGAGTDAVAAELAASRAAIESRRSDPRLHNAAVRARLAGLGEDRARRAPAQRRRELQRAQLRLPLLPTTTIGSYPQTTAIRTARADLRAGTIDDAQYRERMRGEIADVIALQEKLGLDVLVHGEPERNDMVQYFAEQLDGFAATDNGWVQSYGTRCVRPPILYGDVVRTAPMTVEWITYAQSLTGKPVKGMLTGPVTILAWSFVRDDQPLADTARQVALAIRDETVDLEAAGIRIVQVDEPALRELLPLRRADQEQYLDWAVGAFRLATAGVRDDTQIHTHLCYSEFGEIIGAIAALDADVTSVEAARSHMEILDDLTTAGYALGIGPGVYDIHSPRVPSVSEIENSLREAMKAVPAERLWVNPDCGLKTRGRAEVEASLRNMVEAAARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEV9</accession>
    <name>A0A231HEV9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol phosphodiesterase</fullName>
            <ecNumber evidence="2">4.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphatidylinositol diacylglycerol-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphatidylinositol-specific phospholipase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">plcA_1</name>
        <name evidence="7" type="ORF">B7C42_00368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:17093"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58484"/>
            <dbReference type="EC" id="4.6.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47246">
        <property type="protein sequence ID" value="OXR47246"/>
        <property type="gene ID" value="B7C42_00368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004436">
        <property type="term" value="F:phosphatidylinositol diacylglycerol-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLCXc" evidence="6">
        <location>
            <begin position="27"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="32450" checksum="0B7B8191399011C3" modified="2017-10-25" version="1">MPKAAAVGAIDHLDSASNPDWMGALPDSTPLSAMSIPGTHDTMSIHGGKAGPAVVTQEKFDTGCTEPACASERTASTQLEAGIRAFDIRVRRDEAGNLGVQHGSFYQQAGLDDVLRITEQFLDRHPRETILMRVKAECTNEDKTFHCEDAGGLPPDPPLLDRYLNAHPRVWRPAASGPVAIPRLGDMRGTLVVIRADGIDDRGLPVDAQDLWDKPTREDKWAAAATHLARAPAIGTRALSMDFLSASGVPDPAKFPHRYAEYENQHALDYLRSRPGAATGVVMADFPGPALVGEIIAHNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEX1</accession>
    <name>A0A231HEX1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogen peroxide-inducible genes activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oxyR_1</name>
        <name evidence="3" type="ORF">B7C42_00481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47358">
        <property type="protein sequence ID" value="OXR47358"/>
        <property type="gene ID" value="B7C42_00481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="32990" checksum="2D97FF8458D639CF" modified="2017-10-25" version="1">MPETSPVDLDLRLVHCFTLVADHRHFGRAAEALHVTQPSLSRQIHRLEQQLGARLLDRTPQGSRLTEAGEVFLPQAHALLRTAAAAVAETRAAARPSRVVVGYTSGLIVTPAVRELRRRHPDAEVRAQHVPWNDVPAALLEHRVDALVTRLPFPTDRLHVTVLYDEPRVVVLPTSHRLAGKESITLDDIADEPLPRLRDSDPAWNAYWRIDPRPDGRPAPDGPIIDAMEDKLEIIAAGEAIAIAAGFRIHTLRPDLTAVALTDVDPAHVVLATRADHRGRLVAAFRKIAHTVLTGPTPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF60</accession>
    <name>A0A231HF60_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="12">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pacL</name>
        <name evidence="12" type="ORF">B7C42_00715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.8" evidence="12"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47590">
        <property type="protein sequence ID" value="OXR47590"/>
        <property type="gene ID" value="B7C42_00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="900" mass="94932" checksum="6508EBBBD8D0AF75" modified="2017-10-25" version="1">MAALASDRHTGLTTASAEERRNRYGPNEIAAEPAPAPWTVALRQLRDPMNLMLIAVVVVSLVIGEIPTAVVVAVLVVLNVVLGTRQELVARASVDALAKMQSPQARVLRDGVLIQLDALELVPGDIVQLEAGDIVPADGRLVTSATLETQEAALTGESAPVAKDPGTLAAADVPLGDRADMVYQNTSITRGTAIMVVTDTGMNTEMGRIASMLSSVAPSKSPLQRELDSLTKLLGVIAWTAVAIIVVIGALRGQDVTAVLLLGISMGVSAIPTGLPTFVQAMLAYGARRLADAKAVVKNLSDVETLGATSAINSDKTGTLTMNQMTVRSLFFHCRWYGVTGEGYSKNGTVTEAAGAGTPDFTLLAYGLCLDSDATVSDTGEVVGDPTEAALVVLAAKLGIDAPLTRRDCPRVAAVPFDSAYKFMATFHHLRVDGGTRFVELVKGAPDMVLARCASAYRPGRTEVPIDEARAEITAAMRTMSEQGLRVLAFAARILHGQEDAARTDPMSMVENLTFVGMAGIIDPLRPEAVESVRIAHEAGIDVRMITGDHAITAAAIGAELGLGPGAVGGAELQAMTDEQLAQALPNLHVFGRVTPQDKLRLAGVMQRGGAVVAMTGDAVNDAAALKKADIGVAMGSGSEVTKQAGKMVLTDDNFGTLITAIRLGRSIYDKIVSYIRYQMSKLFSLVLLFLVASIFDINHGVALTPLMVLFQHFFITLFPVAVIMTDPPPPNLMNKPPRDPAMPIANRTAFTQWLIYGVLQFAVALAAMLLAPGEMSTDTASVPMTTTFVVLSLGSVLAGLAMRRDPESGFTAPILGALKILSIPVVVTVLAVQLGFLQDLLMTTSLTGGQWLACLGWSVLIPIAVEAEKALRRRHIRRSTPPEPLNAAVAVAPLRARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF89</accession>
    <name>A0A231HF89_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoglycoside phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47620">
        <property type="protein sequence ID" value="OXR47620"/>
        <property type="gene ID" value="B7C42_00745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="73"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="378" mass="43007" checksum="CDC5AB1DBDAEDC59" modified="2017-10-25" version="1">MSGESDTDPGQRRQLTTSARDLDELAERLTQWLAGKLTGTTGPVITGLSRPQAGGMSSSSVMFEASWERDGRTEGGSYVARMPPEEGSFPVFENYDLDTQYAVMAGVGAHSDVPVPRLCWFEPDESVLGTPFFVMERVNGRIPEDNPPYVFVGWVFDATPQQRMRITRATVDIIARVHAIADPAATFPALAGEGSSLRRHFDAQRHWYRWALADDGYRIPLLESGFDWLEQHWPADPGPDVLNWGDARPGNIIFDEFDPVAVLDWEMATLGPRELDVAWLIFIHRFFQDIATRFDQPGLPDYLRRDDVVARYEELTGHRPRDLEWYLVYAALRHGIVMARIKRRMIHFGEDTDTDDRDDYVMHRAALEALLDGTYQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFB7</accession>
    <name>A0A231HFB7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dxs_1</name>
        <name evidence="10" type="synonym">dxs</name>
        <name evidence="12" type="ORF">B7C42_00697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47572">
        <property type="protein sequence ID" value="OXR47572"/>
        <property type="gene ID" value="B7C42_00697"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR47572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="597" mass="62216" checksum="6F86B4C966AB85EB" modified="2017-10-25" version="1">MKPSPRGPDPLAALTGPDALAALSDDDLPALAQRLRDRLVETVTGTGGHLGASLGTVELTIALHRVFRSPTDVLVFDTGHQSYAHKLLTGRASTFDTLRQAGGVAGYPNRAESAHDWVENSHASVSLAWADGIAKAFHLRGEHDRRVVAVIGDGALTGGVAWEGLNNLGAGGRPVVVVLNDNGRSYDPTVGALASHLAGLRDGDIASGNLFDALGFSYLGPVDGHDIGALCTALQKAAALAEPVVVHAVTVKGRGFGPAEADEADRMHACGVIDPVTGVPRSQPAPTWTDIVESELADLARDHPEVVALTAAMRLPTGLGEFSRSAPERVFDSGIAEQHLLASAAGLAAAGMHPVVAVYSTFLNRAVDQVLLDIALHELPVTLALDRAGVTGPDGPSHHGMWDLALLTCVPGMRIACPRDPGRIRELLREAVATPGPTTVRYPKATAGEDISPLARMDGMDILYRGPHSPLDILLVAVGPMAGPCLRAAQLLTDSGFGATVVDPRWVWPINPGLPAIAARHRLTVCVEDGIASGGIGTHLMHAVARDNGAAPVRTLGLPTAFIAHASRDSILAEYGLTGEGIAAACTQWLPATERIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFT0</accession>
    <name>A0A231HFT0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47732">
        <property type="protein sequence ID" value="OXR47732"/>
        <property type="gene ID" value="B7C42_00857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="73" mass="7941" checksum="3A74248ACBDFD529" modified="2017-10-25" version="1">MDISDTVPDVPTRRITVYFGGTGPDGDMVLEYAATRAEAWEFAAAAVHSGLAVTVDGMVRPGLRPLPCRRLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFW4</accession>
    <name>A0A231HFW4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">miaA</name>
        <name evidence="9" type="ORF">B7C42_00833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47708">
        <property type="protein sequence ID" value="OXR47708"/>
        <property type="gene ID" value="B7C42_00833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="34198" checksum="892BC3697851F218" modified="2017-10-25" version="1">MRAPIAVIGPTATGKSDLALELASRLDGEIVNIDAMQLYRGMDIGTAKLPPRQRRGIPHHQLDVLEVTETATVAAYQAAASADVEDILARGRVPVIVGGSMMYVQALLDEWEFPATDIRVREKWEGVLEREGVAAVHAALRTADPVAAQTILPTDGRRIVRALEVVELTGRPFAASQPQRGTPRWNTTIIGVDRETAELDARIETRTETMFAQGLVDEVRELIGRGLRSGLTARRAIGYAQVLAHLDNEYDLSHARERTLIGTRRYVRRQRSWFRRDPRVHWVDGADPRLVDSVLAHVLDEQESIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSR6</accession>
    <name>A0A231GSR6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_08304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000122">
        <property type="protein sequence ID" value="OXR39628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39628">
        <property type="protein sequence ID" value="OXR39628"/>
        <property type="gene ID" value="B7C42_08304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="43" mass="4763" checksum="541B2B81F4AFF52B" modified="2017-10-25" version="1">MDRIWGIGLAADDPRAEDPAQWKGLNLLGFALMDARDVVRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSU1</accession>
    <name>A0A231GSU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000086">
        <property type="protein sequence ID" value="OXR39686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781979.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000086.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39686">
        <property type="protein sequence ID" value="OXR39686"/>
        <property type="gene ID" value="B7C42_08244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="237" mass="25747" checksum="0B0A71873D3E9810" modified="2017-10-25" version="1">MDYARLGLEYVNALKWPFVACYLATLFRAPMKQVIERLRPKSVSYPGGKAEFYEERLEALSAPRPAHQDADANLAVNAQLETEAAVTPGAGVNIEITPARGVGSAPMPTVTVTASTEKSKRLLAAAAQLLREPTRSPQNTIAWAQKVLREQMRAEFGIRSWTDRQLLNAQQLAQAGVDSTLAAQTAEIYALGDGMSRDFQDDVPQSMAENYVEAVAAALTKLAADVDPGYVQHMSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTA5</accession>
    <name>A0A231GTA5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000061">
        <property type="protein sequence ID" value="OXR39808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39808">
        <property type="protein sequence ID" value="OXR39808"/>
        <property type="gene ID" value="B7C42_08120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="7353" checksum="8D88AC7598C017B4" modified="2017-10-25" version="1">MSDGAPVRSNKPRPSRGAMSWLVGCCKALNTVINAANLVVRFLPNTAGTSTASPVTKLIAGLADWFSHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU04</accession>
    <name>A0A231GU04_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40058">
        <property type="protein sequence ID" value="OXR40058"/>
        <property type="gene ID" value="B7C42_07862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15877" checksum="72301441258EC28A" modified="2017-10-25" version="1">MSDHVQLQPPDYHRCLDTVFQSPVACRALLQRLAEMTEGDIRARWSPWMGQQPPPYGPRVWDHVPAAVQLAMLQADYDSVRESANHQYRELAAALEIPPMQYSYVELSHCLRTLLDQQRQRISELEAGTAAGPDPRDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUK5</accession>
    <name>A0A231GUK5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,8-cineole 2-endo-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.156</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cinA_5</name>
        <name evidence="4" type="ORF">B7C42_07648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.156" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782466.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40310">
        <property type="protein sequence ID" value="OXR40310"/>
        <property type="gene ID" value="B7C42_07648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="410" mass="45448" checksum="2B3D061667A0CE44" modified="2017-10-25" version="1">MTTTAEVSADLVVDFDIYDQSLAFPEDTVQARVAELASRGPVVYSTAHGGHWIVTRYQEIHEVLRDPETFSSHPNNLTTTTAGFGKFIPLELDPPEHTGYRLALQPLFSPNRMKALEDDIRAVVNELIDDFAAAGTSEFIADFAHELPTRVFLSLMDWPLSDAPMFTHATDVLLTGIPGASEEESNQARGEAAFKMLAYFQNIIDDRKANPRDDITSQIIHTEVALEDGTRLLTDEELNRMFFLLLIAGLHTVQGSLAWSIIHLSHNPEQRAQLIADESLIPSAVEEILRIEAAVIPGRRATRTTQLGGVTIAEGDQLILMLCSANRDSGEFEDPEELHLDRTPNRHLSFGAGAHRCLGSHLARIELRLALEEIHRRIPDYALVEGDPPVMHASQVRGCARLPITFTPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUM1</accession>
    <name>A0A231GUM1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909915.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40323">
        <property type="protein sequence ID" value="OXR40323"/>
        <property type="gene ID" value="B7C42_07584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12574" checksum="BA09D6A41FA9B988" modified="2017-10-25" version="1">MNYLFVLHDPPYGTERTYNGIRWARQMLDAGHQVRVFNFADAVISVTAGQKVPNGFYNLAKMTSAFTGKGGQIGNCGACMDARGMGEDQLVDGAHRSSMAELADWTAWADQVINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUS2</accession>
    <name>A0A231GUS2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40231">
        <property type="protein sequence ID" value="OXR40231"/>
        <property type="gene ID" value="B7C42_07656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="40" mass="3990" checksum="E48C7C1378AA8417" modified="2017-10-25" version="1">MTWDSLGGNGIGGGCLETKVSRRPSDALGSASASNTVLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV78</accession>
    <name>A0A231GV78_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40524">
        <property type="protein sequence ID" value="OXR40524"/>
        <property type="gene ID" value="B7C42_07463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="426" mass="46903" checksum="76F8D63B05C0B291" modified="2017-10-25" version="1">MLLLAVGIDWAESFHDVALGRPAQGVIEQFRIDHTAAGVARLVARCMELEPDPGEVRVVLETRHGVLVESMVDAGFTLLPVNPDLVARRRGPARKKDDAEDARICCLLALDQFLDLRKLVPHGDLAGELRAIARDDERAARDQRRLLNRLRADLLATFPAAVTIAGDDLGSPIMLKLLAAWPTHAQLAELDRDQLAAFARANRHGWPDRFAARVLAALAVEQLPVRDYLIRAKATTIALAATQLLALREARKAWQRRMGELLLGARREGRAKQPRNPDPGKAVPGGEIYLSFPGLGDVLAARVAGEIGDHIEQFGTPNALQCYGGTAPVTRRSGRSEYVVARRLAHNRYLGAAVHQWAFCSLRASGWARDFYDAKIAKGKSHHSALRALANRWLELLWHCLTRGVAYDEEIHANNRRNAIPATTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV86</accession>
    <name>A0A231GV86_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline transport system permease protein OpuBB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">opuBB_3</name>
        <name evidence="6" type="ORF">B7C42_07366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40557">
        <property type="protein sequence ID" value="OXR40557"/>
        <property type="gene ID" value="B7C42_07366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="26693" checksum="386EEAF660F5C01E" modified="2017-10-25" version="1">MSPAGRHERRADRIRLFIQPVLAVALAAGVLVWAFDRTLTATQQASINPTTISTVVRQHVAITATVVLIVVAVSVPLGTLLTRPRYRRLAPLFVGVANIGAAAPAIGLIVLTYLWTEKTGFWVGVAPIAFYALLPVLRNTILGYQQVDPALVDAGRGQGMSATTVLRRIEFPLAVPYILAGLRTSLVLAVGTATLSFLVSAGGLGILIDTGYKLRDNVTLWVGAILAVALALLVDWLGALAEQFLGPRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVU1</accession>
    <name>A0A231GVU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777742.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40685">
        <property type="protein sequence ID" value="OXR40685"/>
        <property type="gene ID" value="B7C42_07243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="29212" checksum="6FB88A7225DAD570" modified="2017-10-25" version="1">MTRPSWAPEGIDLDRPSASRVYDYFVGGMHNFEIDRTLARQIESFTPNVAETMRANRDLLRRCVRHLIDAGITQFLDLGSGIPTVGNVHEVAQARNPQARVVYVDIDPVAVAHSRAILDGNPHAAVVQADVAEPDTILDDPLVREVLDFDRPIAVLLLGVLHFVPDEADPAGCVARLQQAVAPGSYLAITHATADGQPAEVLEAQKLSGRTSTEIVLRDRNHIAGFFHDWPLLEPGLVHLPLWRPDNPADVGEHPEFSGAYGGLALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW27</accession>
    <name>A0A231GW27_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mercuric resistance operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">merR1_2</name>
        <name evidence="2" type="ORF">B7C42_07114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40830">
        <property type="protein sequence ID" value="OXR40830"/>
        <property type="gene ID" value="B7C42_07114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="16334" checksum="A457BFBC73904EFF" modified="2017-10-25" version="1">MDEGLKIGDAAVAVGVEAHVLRHWESVGLLHPARSPSGHRAYDGQTLDRARLIRTLQRTGLSLRRIRELGLSGRDERLALIADERAQLRRRIDLFEATDRFLAHILDCRHPILAECPDCSGFLGAYGDERDRHELADRAPSTLSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW39</accession>
    <name>A0A231GW39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-asparagine permease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ansP1_2</name>
        <name evidence="10" type="ORF">B7C42_07124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042148.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40840">
        <property type="protein sequence ID" value="OXR40840"/>
        <property type="gene ID" value="B7C42_07124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="33"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="516" mass="54889" checksum="DCE156553C043D02" modified="2017-10-25" version="1">MTTVRPPSEATAPADALHAEDAGYHKSLRPRQLQMIAIGGAIGTGLFLGAAGRLHDAGPGLFLVYAVCGIFVFFILRALGELVLHRPSSGSFVSYAREFYGEKLAFGVGWMYFFHWCMTGIVDITAIATYVHYWGGTRSIPQWLIALVALAIVVSINLISVRWFGELEFWAALIKVIALVAFLIVGVIILGGRFDLDGQTTGPSLLSAHGGLFPTGFLPLVTVTTGVVFAYAAVELIGTAAGEAENPEKIMPRAINSVIARIALFYVGSLVLLGLLLPYSDFHAGESPFVTFFSKLGVNGAGSIMNLVVLTAAFSSLNAGLYSTGRILRSMAMNGSAPKLASRMSSSGVPYVGILATGCIALIGVGLNAMVPDKAFEIVLNMSALGTIFAWTAIILCQLQLWRWSRIGKAERPSFRLIGAPYTSIATLVFLAAVVVLMAASDDDVQRFAVLAMVCVMLPALVAGWFLARRKVLAMATERLGYTGQFPVLAERPLQNEAAESAAESGEPGSAPDAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW67</accession>
    <name>A0A231GW67_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-2-hydroxyglutarate oxidase LhgO</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lhgO</name>
        <name evidence="2" type="ORF">B7C42_07102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40818">
        <property type="protein sequence ID" value="OXR40818"/>
        <property type="gene ID" value="B7C42_07102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="43530" checksum="86F2B1F426EAC166" modified="2017-10-25" version="1">MPEQTVGIIGAGIIGLAIGREITRRRPGTRVVVVDKEDRVAAHQTGHNSGVVHAGIYYEPGSLKATLCARGRQLLRDYCAEKRLPYDEVGKLVVAVTPDDVVRMDALAERAGSNRVPGLRRIDAGEIRELEPHAAGLAALHSPHTAITDFPRIAAAFADDITAAGGQIRLSFPVTGVTRAANGIHLGSDTEELVVDRLVVCAGLHSDAVAGLAGDEPGPRIIPFRGEYMLVRPEKKDLVRGLIYPVPDPRYPFLGVHFTRRVNGEVEVGPNAVLALAREGYRRSAVSARDLRDLAAWPGSWRMARRHWRTGMREIYGSLSARAYMRAAQRYVPDIGVRDVFRAGSGVRAQAVDAGGELVDDFRIHRLGPITAVRNAPSPAATSSMAIAEHVVDVLEQDGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW98</accession>
    <name>A0A231GW98_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dibenzothiophene desulfurization enzyme C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">soxC_6</name>
        <name evidence="4" type="ORF">B7C42_07038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783809.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40903">
        <property type="protein sequence ID" value="OXR40903"/>
        <property type="gene ID" value="B7C42_07038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="3">
        <location>
            <begin position="249"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="424" mass="45914" checksum="2C952220C341FF0A" modified="2017-10-25" version="1">MTPISRPDSPAEALVRIREVLAEFAKGAGERDLSFEHPDELIRALGDAGFGRLRVPVEFGGFDVDLPTLFDLLAEAGRADSNIPQIWRGHFTTTEILRAETDSEVRAYWLHRIGAGAVFGNAQSEPSAVIAAAEAAGTVTGEWGSTTTRVRTDEHGRRLVSGTKFYSTGSRFADFIRAAVVDEDGHRGFVVVPAHHPGVTHADDWDGIGQRQTGSGTTLFHDVPVEEHGDIGRYRESLRGLDSFVQIVHLANLTGIARSIVAETVDLVRGRTRTSLHALTRNAAEDPEVLGVVGRLEVRRRTAETLLRHAAVTLEAAHTSGAEADFGYAYVETSAAQVAVIEAVLDAATTAFDALGSSAVRNSVHLDRHWRNARTLASHNPVVYKPRLVGDHLVNGVTPQPGYYRDRPSVADAGEPAVEVRSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF2</accession>
    <name>A0A231GWF2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trkA_1</name>
        <name evidence="2" type="ORF">B7C42_06923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40957">
        <property type="protein sequence ID" value="OXR40957"/>
        <property type="gene ID" value="B7C42_06923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="131"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="23287" checksum="CA6CE5106B0C7BDC" modified="2017-10-25" version="1">MGCGRVGSALARALVRIGHEVAVIDRDPGAFLRLGKDFPGERVTGVGFDRGVLTRAGIERAGAFAAVSNGDNSNIISARVARETFGVERVVARIYDAKRAAVYERLGIPTIATVPWTTDRFLRTLTGDETTATWRDPTGTGTVTELVLHEDWYGRTVRDLEDAVPVRVAFLVRFGQALLPTSKTVLQADDAVYIAAVSDKVGEAVAVAATAPSSEDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWL3</accession>
    <name>A0A231GWL3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40972">
        <property type="protein sequence ID" value="OXR40972"/>
        <property type="gene ID" value="B7C42_06938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="30417" checksum="577A636D2ED7D4CE" modified="2017-10-25" version="1">MLQIDQFTYGWLTPALAYLMSVIGSLLALRCMVRARANPGHRGWIVTAAVALGGTGVWVMHFIAMLGFSVHGATIRYNIPITLISAAIAVVVVWIGLSLVIRRQGDTSALLTGGAVTGLGVAAMHYAGMYAMKTDVAMHYDPWPVIVSIVIAVVAATAALWFALHVEGLPATIGSAMIMGVAVCGMHYTGMYAMQAHMSDHMQAPSGAQANELLTPLIIGVSMVTLLLFLQVGITDIHEPDLSRIRGQRASRYWPSSTESLPPAAEPSAREEYPGDETHRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWX0</accession>
    <name>A0A231GWX0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41120">
        <property type="protein sequence ID" value="OXR41120"/>
        <property type="gene ID" value="B7C42_06890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="378" mass="40993" checksum="538D925549A35BCF" modified="2017-10-25" version="1">MKAPDIRLDALRGSAPRLPYNARSLAALENNPRCTLRAVLDASGSDKAKIADRAGYSTHYGQSIFAITRGNSFEAMVKAHGGAELLRVLRETLHLEPSEVAHADLNDVSGDPTPSVRHTRTCQRLVAVARGQEQGTLFDHPMLMLTVGGHKVYLEPDLVAFRVRGKFHVVEVKSFPIIDRQANPALVRSATTQAAAYIIALRTMLAEHGIGPGAVSDTVVLVAPKNFSNRPTGERIDARKQVRNLARQLQRLDKISDIVDKLPEDLTFDLVDGDGRPRSTEELLDALTAVESNYRPDCLNHCEMAFFCRSRARASMSVDVLGPVVREQLGGIDTATMALGLARGELTPTADQAETAAALRHAARLRAELTETAAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX30</accession>
    <name>A0A231GX30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid-associated protein Lsr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lsr2_5</name>
        <name evidence="3" type="ORF">B7C42_06720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41125">
        <property type="protein sequence ID" value="OXR41125"/>
        <property type="gene ID" value="B7C42_06720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="112" mass="12609" checksum="CAE217362C25F403" modified="2017-10-25" version="1">MAKKVIVELVDDYDSKSEANETVHFAIDGIEYEIDLSTKNANKLRGIFEQWTSPARKIGRNSKHTKTTGGPQAQSDRQQTAAIRDWARNNGHEVSRRGRIHKDIIAAYNNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX36</accession>
    <name>A0A231GX36_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ESX-3 secretion system protein EccA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eccA3_2</name>
        <name evidence="4" type="ORF">B7C42_06789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41193">
        <property type="protein sequence ID" value="OXR41193"/>
        <property type="gene ID" value="B7C42_06789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023835">
        <property type="entry name" value="T7SS_EccA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03922">
        <property type="entry name" value="T7SS_EccA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="353"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="599" mass="65483" checksum="83E5AF6FA7E1B733" modified="2017-10-25" version="1">MVRAGESVERDVQVSAAEDAFYTGVQSLGLVAGGVRNEQQAMAAFRAATDLDPDMCDAWLGRAMAGDITSEVIYGAYRSVHNLYRDQQRAGLIDRSLWCQVEIGMYGLRVAMADRDQIAIAQACSYAEGGEWQEAAAILDQVPSDDVADFVRMSLFFRTKRWSDVLAARTAKPVIEDGLLDIAAELMAAQALAHLGRLGEAMPRAQRIVEDSSSGNLSYIWADAHFLLGMLYRHNGDHENADRILKGLQGSGLWSEREEWQRAVRDKTYRLEVTTPDLLASRTDLWDPTTGDDPAEAAAASAKQEREALLSEASELLQAQIGMDSVKEQVDRLKSGVLMDQVRAKRGLAVESKSQHLIFSGPPGTGKTTIARVIAKIFAGLGVVENPEVIEVSRNDMVGTHLGHTAPKTNALIDSALGGVLFIDEAYTLIQEGLSGGDAFGKEAVDTLLARMENDRDKLVVVIAGYEDQIDRFLASNDGLASRFTKRIRFSSYGGDELVQIADHIARKKDSLLSEQAREVLRERCDQLASQTRNGRRLIDLAGNGRFIRNVVEAAEAERDYRFTRENVDIAALTNEELMTIDAFDIAAALSGLAPAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXA0</accession>
    <name>A0A231GXA0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-aminobutyraldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prr</name>
        <name evidence="6" type="ORF">B7C42_06627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.19" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41229">
        <property type="protein sequence ID" value="OXR41229"/>
        <property type="gene ID" value="B7C42_06627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033737">
        <property type="term" value="F:1-pyrroline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019145">
        <property type="term" value="F:aminobutyraldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="31"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="495" mass="51917" checksum="5FC9269C1371AB8A" modified="2017-10-25" version="1">MITPQVIAAAQRRIRNVPRTHFIGGQFHSAEGAEDISVVNPSTEEVLGTFANGTAAELDAAVAAARAALPGWRRRTPGARAEILFAIADIVDDNTELLAAIESINGGKPLAAALEEIPVVSDCLRFMAGAARTAQTPAAGEYVSGMLSYIRREPVGVVGAVTPWNFPLMMAGWKIAPILAAGNTMVLKPSQLTPFSLLVLMELAGDVLPPGVLNVIIGRGSEIGGALARHPGIDMMALTGSLASGQAVARDSAPGVKRVHLELGGKAPVVVFPDADLDALVETLIATGYTNAGQDCGAATRVVCHHEVHDIVVEKLVAGAESLVTGDPCAEDGVQLGPVIGAMQRDRIAAMVDQARSDGAKVATGGFIPDRPGFFYPATVITDVAAGTPMAREEVFGPVISVETFTTESEALSKANDVDYGLAASVWTSDQQRALRMIEGLDFGSVWANTHLAFTTEMPWVGFGKSGYGRDNSIYALDDYTRTKHVMLPLGEPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXC4</accession>
    <name>A0A231GXC4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41215">
        <property type="protein sequence ID" value="OXR41215"/>
        <property type="gene ID" value="B7C42_06613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="105" mass="11186" checksum="5BD91E0CFB4F4436" modified="2017-10-25" version="1">MAVSGAAPLDRELGSAVAHRLGTTVMQGFGMTELSPVSHAVPSDPGLSIAGRAADISSSGWPIVLSSRIRSHRTQGPLRRVRGRDTRVHGEKGPPKELRQRVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXR6</accession>
    <name>A0A231GXR6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41389">
        <property type="protein sequence ID" value="OXR41389"/>
        <property type="gene ID" value="B7C42_06532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="8194" checksum="C3BF665B817D0F6C" modified="2017-10-25" version="1">MLGSQRDDSALCEQPPGTGSVYIVVDDPDALFQRARDAGATIVRGLRDEDYGSRGFTCRDPEGVFWSFGTYAGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY18</accession>
    <name>A0A231GY18_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41478">
        <property type="protein sequence ID" value="OXR41478"/>
        <property type="gene ID" value="B7C42_06370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="423" mass="44652" checksum="4938670CB2464D5B" modified="2017-10-25" version="1">MTCGAAETDRLSPDFHRLWQASTVSQLGSALGAGALPLVAILVVHASALQVSLMAAIAGIASAAIALPMGSFIEFRRKRPIMMHADLVSFAALASVPLAACFGALTYGQLCVVLALQTLCEMVFNAASGAYVKAIVAESQRVRANSRFESTFWTASTIGAPIGGVLITTFGATITVALDAVSYLLSAFGTRSIATVEPRPAHAPTEHQWRREIRSGWTYIFDHPVLRLLFWNGMLFGGAVTLTTPLLALLMLRELHFAPWQYGLALGLPCLGGLLGSLCSPRLVARFDQRAVLLGSGTLRTCWMGLLLIAGPSPLGLLVILTAETLLLLCAGVFNPVFATYRMNCTTDDHMSRVRTAWSISAKSVQPVFIALGGLIAGATSPRVAIGCATAAVLASSALLPWRQTETTAPRDSDGTASAHCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY64</accession>
    <name>A0A231GY64_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein YdfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydfJ_5</name>
        <name evidence="8" type="ORF">B7C42_06432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41540">
        <property type="protein sequence ID" value="OXR41540"/>
        <property type="gene ID" value="B7C42_06432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="741" mass="76989" checksum="2DADA2C6A8E1E466" modified="2017-10-25" version="1">MSRYLFVLGGLVTRHRWWVLVVWIVLLGGAIGFGVGSGGRTTDNFTVPGTESQDAVSLLQQRMPAYSGAQMQVVFAAPGGTKVTDAQPHAEIEQAMAGFRGLPQVATVVDPFDAHAISPDQRVALGSVQFSVSAGEVAESTLDEVTRVATPARATGMQVEFSGAVYPGFTAEIPEGPEIVGIAAAFVILLITFGAVVAAGLPVLTALIGVGIGVTGVLGVAAFVDVPSAAVSLALMLGLSCGIDYALFVLSRHRNNILRGTTVVESIPLAVGTAGSSVVFAAVTVIIALCGLSVADIPFLTVMGLTAAGAVLVAMLVALTLLPALLRIAGETVAKFISPPLHPGRPEKVARIAANEPERTVGYAWGRTVTRFRIPLLILGIAVLVILALPVTRLDLGLPSGASQPDTSTAHKAFVLVDNSFGPGFNGPLLLPTDTTHAAAPDAVQTLIARLQQEPNVALVQPAGTGDNLVLVQVIPKTGPTHDATADLVTRLREDRPRLTGDLGVSYLVGGTTAANIDTSDRLAGALPVFLGVVVGLALVLLTIAFRTVLVPLSSIAGFVLSVFSALGAQVAVFQWGWGAGLFDVTAGQTLSFLPIIILAIIFGLSSDYQIFVVSRIKEEHSHTADAIAAVQNGVAHSARVVTAAALIMFGVFVAFVSVDNPIVKPLAFTLAVGVLLDAFVVRLTLVPAVMALVGNRMWYHPRWFGRLVPDLDIEGARLEDRVRGDHAAAAGAETARTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYT8</accession>
    <name>A0A231GYT8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA mismatch repair protein MutS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutS</name>
        <name evidence="4" type="ORF">B7C42_06332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41691">
        <property type="protein sequence ID" value="OXR41691"/>
        <property type="gene ID" value="B7C42_06332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="3">
        <location>
            <begin position="325"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="506" mass="56308" checksum="64014980F4C4F201" modified="2017-10-25" version="1">MPTVSVLWPVPAEHVASVEVGADALTDLEIAPLIAAIVGDTDDHDLTALLHRPVRDPDTVRFRQEVFTDLDHGETHSAAEEFVIAMWRVRRRLRVAGELYHPHQRHRLHLDAAADYVTAVTALHTAAARLPLRSRALRRWRTYLDTYCASSDLRTLADDIDTAHAALAQVRYRLRIVDRTLEVSAAHPAPDYTATVTHLLARFGAPHRHDPRPRPQWPDMNQTEEHILDRVAAHYPAPFARLAEFATRHRDFIAPEVADFDRGMQFYLRYRRFAHRAAGTGRSVCLPEIAAPGEPIHADRAYDLALALRSPNPVVCNDFQLDGPQRLAVVTGPNQGGKTTFARTIGQLVYFAALGGPVPAHTARLPLPDRIHTHFERAEHAGAPDGRLLTELRSMREILRTASADTLIVLNESFSTTTTCDGVRIAGEVLAHIVRRGAWGVWVSFFDDLAEAGPEVVSMVALTDPHDRAHRSYRIVRRPADGHAYATELADRFGLGYDAVAARLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZE2</accession>
    <name>A0A231GZE2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate/thiosulfate import ATP-binding protein CysA</fullName>
            <ecNumber evidence="5">3.6.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cysA_2</name>
        <name evidence="5" type="ORF">B7C42_05961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.25" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778983.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41977">
        <property type="protein sequence ID" value="OXR41977"/>
        <property type="gene ID" value="B7C42_05961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="25839" checksum="4F69776FE87C2F89" modified="2017-10-25" version="1">MGTVAVRLAGARKSYAHHGTPVLDGVDLEVAAGELLVILGPSGSGKSTLLRIIAGLDRLDGGSIGWGDGQPNPATGMVFQQPLLMPWLTVRDNVRFGGRFARHRADFDPAGTDALLERFGLAGLSGRMPDELSGGQAQRVAVMRAVAVRPQLLLLDEPFSALDPAVRADLQDWLAALVADLGCTTVLVTHDVDEALRLGDRIVLIGHGGTVRAQFPRPGSDDERNTLRHSIIDRYRDVSVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZG4</accession>
    <name>A0A231GZG4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_26</name>
        <name evidence="1" type="ORF">B7C42_05991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779091.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42007">
        <property type="protein sequence ID" value="OXR42007"/>
        <property type="gene ID" value="B7C42_05991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="27077" checksum="A13C563646EBCEA9" modified="2017-10-25" version="1">MDLQLSGKRAIVTGGSKGIGLAVARGLAAEGVDVVLAARSAEPLAAAAQALAQESGRRIVAVPTDTGDDEQVRALVERTVAELGGVDILVNAAATPWSAGAPADLNATSDDIVRREVEIKVLGYLRTARAVAPHLIAQGWGRIVNISGLGARQANSIAQTVRNVGVSALTKNLADELGPHGINVTVVHPGLTRTERLTERLAAQAAESGAAVEELEAGLVANSIRRVIDAREVADVVTFLASPRSIAITGDAVAAGGGVPGPVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZM4</accession>
    <name>A0A231GZM4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine 3-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.276</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdh</name>
        <name evidence="3" type="ORF">B7C42_05976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.276" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41992">
        <property type="protein sequence ID" value="OXR41992"/>
        <property type="gene ID" value="B7C42_05976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031132">
        <property type="term" value="F:serine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="29951" checksum="6FB42C4668C2271A" modified="2017-10-25" version="1">MRRAPSTSAAHPNEGTMTTSPRTALITGASAGIGATFARHLAGRGYQLLLVARRGDRLQELAAQLTERHDVRCEVLAADLTDPAAPAAIVNHADQQGLDIDVLINNAGLSGKTAFADTPWDALAGEIQLMVTAPTELIHLVVPGMKKRNWGRIVNLSSVAAFAPPAASLLYTGIKSFVLNTSQALDMELKPHGIHVTALCPGFTHTEFHDVMGTRDKADHLPRILWQQPEAVVTEGWAAVMKGKPVCVPGTLNKISAAAMKPLPTHLSYLAGKTLNPFKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0C3</accession>
    <name>A0A231H0C3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42315">
        <property type="protein sequence ID" value="OXR42315"/>
        <property type="gene ID" value="B7C42_05514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="59" mass="6725" checksum="7D268E43729D4411" modified="2017-10-25" version="1">MNRLADATSPYLRQHADNPVDWREWGAEALEEARARDVPILLSVGYASCHWCQLICEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0S8</accession>
    <name>A0A231H0S8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42438">
        <property type="protein sequence ID" value="OXR42438"/>
        <property type="gene ID" value="B7C42_05639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041458">
        <property type="entry name" value="DUF5593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18007">
        <property type="entry name" value="DUF5593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5593" evidence="1">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="37661" checksum="08DD715051BC31E8" modified="2017-10-25" version="1">MADAESVGSPWLLVETLAPASGPTIVADGPRVREWTSLSRAGRSLGAGASALAAAAVELAAAAVPSDSVAESADNRIVVSEGGWTAIAVPVFCSFGAVHGVQLWVGAARQQPPPRRAVAAWDWDSDTELAHHGPGLEELAFARAREHVRVVRTPPEVFGRMVRFDERMGYTAVVAGTDPAGRWQGELAIRGDDEIVRNFQLVIRVHREDPHSAVSTRTAHITRALLHEITDVSPPRPDTDLAITRAVSRSPDAGVGFVELALGLVYEWASPPPPPLEGWSTERPIVHPDDQRDYRAAFAAVFADDIDAPAREFVFRIRFEQSDWIVVRAELSRLGPERAHGMIRVAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0U0</accession>
    <name>A0A231H0U0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42458">
        <property type="protein sequence ID" value="OXR42458"/>
        <property type="gene ID" value="B7C42_05234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="21914" checksum="DF54BFCC7BA192B1" modified="2017-10-25" version="1">MSNSSSRLSSGRASSCARNARSTRWLVGRGSPTGIRPVRCLPSAAPSSITASGLPPASSSTRRRRWTSSVRGASRRVCVSNCSDSSGRSGPSSSRWIPSSRGVWPPILARSAHNSSNGALLNRRATKASTSSDDWSSHCASSTRSSNRPVVADSSSNPSTASETSRRSGGGPSSRPNAVIRAARCRRGSASAWASTGWINSWIPAKPTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0V8</accession>
    <name>A0A231H0V8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Copper-exporting P-type ATPase A</fullName>
            <ecNumber evidence="10">3.6.3.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">copA_2</name>
        <name evidence="10" type="ORF">B7C42_05622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.54" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42421">
        <property type="protein sequence ID" value="OXR42421"/>
        <property type="gene ID" value="B7C42_05622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="745" mass="77408" checksum="950F2E73E80080A1" modified="2017-10-25" version="1">MSAPTTERSVELDIGGMTCASCAARIEKKLNRIEGVTATVNYATEKAKVSFPETVTPDQLIERVVDTGYTATVHDTRPAETAAAEEVSADSPLRQLRHRLLVSLALALPVIALAMIPALQFRNWQWLSLTLATPVVFWGGAAFHRAAWINARHATATMDTLISLGTLAAYSWSVYALFFGDAGMPGMKHGFSFAVERSASASNIYFEVAAGVIVFILAGRYFETRAKERAGSALRALLELGAKDVAVLRDGAEHRIPVSELRVGDLFLVRPGEKVATDGVVTDGNSAVDMSMLTGESVPVEVGPGDPVIGATVNAGGVLTVRATRIGADTQLAQMAALVEDAQNGKAPVQRLADRVAGVFVPIVIAISVVTLGFWLGSGAAVAVAFGAAVAVLIIACPCALGLATPTALLVGTGRGAQLGILIKGPQVLESTRRIDTVVLDKTGTVTTGTMSLTEVIPAEGQDRAELLAVAAAVEHGSEHPVARAVVRGAAEQGLAEEPVQQFVSHGGKGVQGLVGERAVVIGRTELLADWSVTLPETLAQAKSEAESAGRTAIVVAWDGQARGVLVIADAIKASSAEAIADMRSLGLTPVLLTGDNAATARTVADQVGIDEVIAEVLPADKLDVVKRLQDQGKVVAMVGDGVNDAAALAQADLGLAMGTGTDVAIEAGDITLVRGDLRTVGTAIRLSRATLRTIKGNLFWAFGYNVAAIPLAAAGLLNPMLAGAAMALSSVFVVSNSLRLRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H158</accession>
    <name>A0A231H158_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42593">
        <property type="protein sequence ID" value="OXR42593"/>
        <property type="gene ID" value="B7C42_05370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="17905" checksum="8394299DF059478F" modified="2017-10-25" version="1">MLDINALRDAYRTLLEAADTVADSDQTIAPAPGEWNADQILGHVCLITAATIAAASAVAAGEHTTYDNRIALDIWTIDRVIESAGGSTGLRDRLQRQAEVLCGFSGPALSDTEFDTLVSTRLISDDAVLVDQPLPLRDLFIGLADVELPGHTEQLLALLHGRTTEATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H197</accession>
    <name>A0A231H197_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42625">
        <property type="protein sequence ID" value="OXR42625"/>
        <property type="gene ID" value="B7C42_05403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="16468" checksum="2EF9DEF849B07755" modified="2017-10-25" version="1">MDDIDDFDVDGFAAVIEDFNRGYIRIPVREKLPFTTLSVLDTLAQRGPMRLTELTETEQMTQPGITQLVARLERDGLVLRRRDPGDGRAVLVHLTEAGRHIRQSRHDDRVRYLVPLIGELSTAQRRALAAALPALSRLAQLERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1C1</accession>
    <name>A0A231H1C1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42640">
        <property type="protein sequence ID" value="OXR42640"/>
        <property type="gene ID" value="B7C42_05418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="9735" checksum="474032674717C0DF" modified="2017-10-25" version="1">MAGISSVPTSALAAGGLLGGFALAQATGQRQLGGVVFAAATAAAVPRWRAALGTPGAAALTGLSVGAMGASHPLAEKIGAWPSVAVVSGAVALTSWVLADRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1H0</accession>
    <name>A0A231H1H0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloalkane dehalogenase</fullName>
            <ecNumber evidence="2">3.8.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaA_2</name>
        <name evidence="2" type="ORF">B7C42_05029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42693">
        <property type="protein sequence ID" value="OXR42693"/>
        <property type="gene ID" value="B7C42_05029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018786">
        <property type="term" value="F:haloalkane dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="32155" checksum="25760A96906F37AF" modified="2017-10-25" version="1">MEPDYRTWIAGGSHLELSGHRIFHRQDGPVDGRPVTLLHGYPTSSHDWVSILPALTESGCRVTTLDFLGFGASDKPRGHDYRMTEQATLVEQLWQRLGITGTALVAHDYGVSVAQELLARDSARVRRMAWLNGGLYPDLYRPLPIQHLMTTPIGKILNPLMSETTFRMTLRRILGRPVSDADLHQMWLAMTDCGGKRVQWALNRYHAERRANAGRWQQALESYSGPVLFVWGPADPISGGHLLPRLRERLPRARFEVLDAAPATGHYPQVENPGPVAAALVEFLAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1L5</accession>
    <name>A0A231H1L5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42731">
        <property type="protein sequence ID" value="OXR42731"/>
        <property type="gene ID" value="B7C42_05068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="213" mass="22087" checksum="C484096537CFFA27" modified="2017-10-25" version="1">MSDDTGTEPKRAVDAEAESSEPTTAEPTTAGTGVEPAKAPRTLSIRLSTVVTAAAAVVLIALAAVFGSLWLSARGDLHDRDDRAAAQQHAEQVATDYAVGASNIDYQNVGAWIGKLKAGTSSQLAQKFDATAPKLQEILVPLKWTSSATPIAAKVMSTENGVYKVDVFLNVNSTSAQTPQGAQTTVTYTVDVDPGSGWKVTDVGGMAGALPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1S4</accession>
    <name>A0A231H1S4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 107B1</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42799">
        <property type="protein sequence ID" value="OXR42799"/>
        <property type="gene ID" value="B7C42_05137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="419" mass="46208" checksum="2D64A19CBDE99F43" modified="2017-10-25" version="1">MKYSDSAQAADPILELTDDFYQDPHAVYRELRARGPIHRIRLDGVLGWLVVDHDVAKQAFLEPGISKRIGSPEGQAVLAQNGAVDQFNGAINDNMLFADPPQHTRLRKLVTKAFAGRAIRELGPRITTLADELLAEMATRDRVDLLDAFAFPLPVAVICELLGVPDDDKDDFRAWTAVVVDDSAPIEERTTAGVNFFTYLTKLIAARTDSPGDDLLSELIIAKEDGDRLDQSELISMLLLLLAAGHETTVNLIGNAVYEMLRNPRITERLRAEPETVPAYVEEILRSQGPVHLATARYTTRPIVLGGREIGAGEFIMISLAAANRDPDRFTRPDLVHVDRADNRHIAFGHGIHFCLGAALARMEATIAVNRLLDRIPDLCLDPEFGPPIWRRSLLIRGLATLPVSMVPANEPEPEFSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H218</accession>
    <name>A0A231H218_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42891">
        <property type="protein sequence ID" value="OXR42891"/>
        <property type="gene ID" value="B7C42_05230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="9074" checksum="45DF0745B1921E93" modified="2017-10-25" version="1">MAHLDVKKVGRIPDGDGWRIHGRDSEPAKAASLAKSAGAKRGYIYLHSIVDGFSRLAYTEPLSDEKGTTAAAFLTRAKAWFAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H299</accession>
    <name>A0A231H299_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42968">
        <property type="protein sequence ID" value="OXR42968"/>
        <property type="gene ID" value="B7C42_04854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16767" checksum="8047287DC19D0EC1" modified="2017-10-25" version="1">MSTEHEGLSLDEGVRAMVLLMPRLVGRAKRLPVPEALRSFDLAPRHLSLLTYVLFDGPLTVNELARRLEVAPTTVSLMIGDLSRQGVLERRTDDNDRRRTLVAIADAHRTAVADWLGGADRGWRAALGPLTAEQRALVITTLRAYEEAVSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2V0</accession>
    <name>A0A231H2V0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadK_2</name>
        <name evidence="3" type="ORF">B7C42_04594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43172">
        <property type="protein sequence ID" value="OXR43172"/>
        <property type="gene ID" value="B7C42_04594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="431"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="521" mass="55065" checksum="C4EB995D070215B3" modified="2017-10-25" version="1">MLVDPAAVVSDTDPIAAEGFWDLIRERAQRSARLPMLADEHGTTLTFGDFHGRAERVAAALRAEGIGPGTRVAWQLPTRISTLLVMAALARLGAVQAPIIPIYRERETGAAVAAAEADTMLIPGTWRGTDYRAMAEGLPGTRRVLTIGTSAPESADVAALPPEPGVSQDIRWVYFTSGSSGLPKGVCHGDSSLLAAARGFTQRGGLGREPGEVGGIPFPVAHVGGVVYLMSLLLAGFPAVVVEAFDPATTSELFRRHRVTFTGGSTVFYTALLNQQRTLPPGERLLPSLRVLKGGGAPCPPSVYHAVRAELNATVAHDYGATEVPMICVASPDDTDEQLANTEGRPIPGLRLRVVGAAGELPLGQDGEIQVQGASVFRGYTDPELTAAAFTADGWFRTGDLGHLRSDGHVEVTGRLKDMIIRKGENIGPVEVEALLAEHPAVAEVAVIGLPDDERGELVCAVIAVRPGAATPTLDEVAARLRWAGLMPQKLPERLEVLAELPKTGLGKLDKQSLRRTFSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3D2</accession>
    <name>A0A231H3D2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43364">
        <property type="protein sequence ID" value="OXR43364"/>
        <property type="gene ID" value="B7C42_04231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="28811" checksum="D6609BCD3C31C48B" modified="2017-10-25" version="1">MAPEAVGVPVGSRRRAAGLRREELAALAGISADYLTRLEQGRATAPSAQVVEALARALRLSDTERDLLYRLAGHAAPGPDVVPSRVTASVHRVLDRLSHTPVVVYDASWTLVLANAPYNALMGDTTSWRGLERNAVWRNITRMPTRVVHSEREQAEHEARLVADLRLTASRYPADRALRRLIADLGSAGARFTDLWNAETPPPAPDPSRRKTIDHPAVGLITLDCDTLLVTLDDLRISVYTAEPGTEDAARLDLAVVLGTQSLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3I8</accession>
    <name>A0A231H3I8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43439">
        <property type="protein sequence ID" value="OXR43439"/>
        <property type="gene ID" value="B7C42_04306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="25279" checksum="E46216000CDDD97E" modified="2017-10-25" version="1">MTAETRSHRRTTTLPDAFGVFVRRPSPWIITTLLAGALTARIAVGDWQLTDALVAGVMLAFFPVTEWMIHVCILHWRPRRIGRLTLDSLLARKHREHHADPRWVDLIFIPWQTFLWLFPALVVVAALAFPRIGLGLTFLTVVGVLGLGYEWTHYLIHTDYQPRTRLYTAVRRNHRLHHFKNEHYWFTVTSSGTADRLLGTYPDPASTPNSRTATALHGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H406</accession>
    <name>A0A231H406_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">petF</name>
        <name evidence="2" type="ORF">B7C42_04521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43653">
        <property type="protein sequence ID" value="OXR43653"/>
        <property type="gene ID" value="B7C42_04521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="13406" checksum="522BE6A9E40EBDA1" modified="2017-10-25" version="1">MTDPTPTRPVVRILPAGIELAVEPGETVVDTIRRHGYRTRYSCRRGGCGACKAQLLAGTVHYRNPVAATVLSDSEQVTGACLPCRAIPDQNIVIRLSERDRLRNVLGLLSRSSTAVPREENTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H462</accession>
    <name>A0A231H462_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentachlorophenol 4-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcpB_2</name>
        <name evidence="2" type="ORF">B7C42_04495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.50" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43627">
        <property type="protein sequence ID" value="OXR43627"/>
        <property type="gene ID" value="B7C42_04495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018677">
        <property type="term" value="F:pentachlorophenol monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="477" mass="50708" checksum="98B4AC46B4DF9EE5" modified="2017-10-25" version="1">MTRPVLIAGAGPTGLTLAIDLARRGIDVRIVDKATTPFSGSRGDGIQPRTLEVFDDLGVLDAVLAAGSPAPLMRAYLDGTLVAERRMSESRAAGPAVPYPNPWVLGQSDTERLLRDRLAEFGVHVEFGTALAGFTQDADEVRATLSGPGGTENVAARYLIGADGGAGTVRRTLGIPFEGTTDESIRMLLGDVPVDALDHDFGYWFATAATPTAGVALTPLPGGRLFQFAAPLGDDPRPTRAVLQERLDRVSGRTDLIVGEPVWSTVWRPNIRLAQRFRSGRVFLAGDAAHVHPPTGGQGMNTGIQDAYNLGWKLAAALSGDPGPLETYESERRAVARRVLGLSTALLDKHLEGHEDAMNRGAETHQLDISYRDAADTAGLTAGDRAPDAPLRRDDGSALRLFDLFRGPHATRLTFGAPAEATEVAGVRAYSIVAPGHRLEPGQLIAVDGHAFTDYAATAGTQVLVRPDGYLAWHRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H475</accession>
    <name>A0A231H475_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43664">
        <property type="protein sequence ID" value="OXR43664"/>
        <property type="gene ID" value="B7C42_04532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025597">
        <property type="entry name" value="DUF4345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14248">
        <property type="entry name" value="DUF4345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="12845" checksum="E6BEC563D66912E9" modified="2017-10-25" version="1">MNTAPHRPYQDRLVRAYLAIAACAFLLIGLNGLFAPVRAAAGIGFEILTSAGLNEMRANYGGLQLALAGLLAGGAVRAAVAKPALALTVAVCGGLVFGRLVGFAIDGPLEQASCRGLYWKSWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4B8</accession>
    <name>A0A231H4B8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43678">
        <property type="protein sequence ID" value="OXR43678"/>
        <property type="gene ID" value="B7C42_04546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16811" checksum="4F79D70FE0D325D6" modified="2017-10-25" version="1">MRTLTVTQIIPAPIDDVFEAFTDHEKFSEVFGVRSCTLIKQGSAEKNGLGAIRELDCGLLRLREEVTGFDRPHRMEYKIINARPRADHEYGQVDFIEVPDGTKVTWSTRFGNRSPLGGLLDRGFAIAFGIAFRLTLRSAEQRAVAASRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4N7</accession>
    <name>A0A231H4N7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UPF0336 protein B7C42_04097</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43859">
        <property type="protein sequence ID" value="OXR43859"/>
        <property type="gene ID" value="B7C42_04097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="5">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="4">
        <location>
            <begin position="237"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="38668" checksum="929CE224BD85F108" modified="2017-10-25" version="1">MTINTGTDAVAAQNAEGEPFDPSAHAAAMVGHHYRVDDYYEVGREKVREYARAVQDYHPVHWDEDVAREYGHDGLLAPVTFISLVGILAQRKLFEQVVTGYDLSQIMQTDQILEFHRPIRVGDQLTCDVYLHSFRQAFGGDIIVTKNIVTAQNDELVLTTYTTLVGRSGGDVDPNIADAVRNILMHGMAEAPDRPTAEPPITAPPVPVTTVPEVTVSSHTRSFDSVAVGDELPARVVRLTRGDLVNYAGVSGDANPIHWSDEVVALAGLDNVVAHGMLTMGLGGGFVTSWLGDPGAVKEYNVRFTSPVYVPGDHPAEVEYTGKVKSVDPENRTAVIAIVAKSGGRKIFGRATATVQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H501</accession>
    <name>A0A231H501_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TP_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43979">
        <property type="protein sequence ID" value="OXR43979"/>
        <property type="gene ID" value="B7C42_04218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043819">
        <property type="term" value="F:precorrin-6A synthase (deacetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11643">
        <property type="entry name" value="Precorrin-6A-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012797">
        <property type="entry name" value="CobF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036525">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02434">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="28839" checksum="07F753691B5741D4" modified="2017-10-25" version="1">MVRWLAWGTVRMLYVIGIGAGDPRQVTVQAVEAIRQVDTFFVIGKGETKRELTEVRAAILAGHADPDHRVVAIADPPRERTVEGAADYREVVEDWHRRRAELLAEAFDATEGVGGILVWGDPSLYDSTLRMVRRVLDAGTRFEYAVIPGVTSAQALAAAHRIVLHEIGEPVHITTGRRLRTEGVAADGSTLVMLDGECSFTQVPGDDLHIWWGACLGMPEETLIEGPLRAVEDRIIRRRNELREAKGWVMDIYLLRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5A5</accession>
    <name>A0A231H5A5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_03607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44051">
        <property type="protein sequence ID" value="OXR44051"/>
        <property type="gene ID" value="B7C42_03607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="434"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="556" mass="57552" checksum="78154E2018BEE98C" modified="2017-10-25" version="1">MSSVMVAPTLAGYRRTWLRPDIVAGLSAGAVVIPQAMAYATIADLPVQIGLYTCMVPMVVYALLGGSRTASVSTTSTIATLTASTLVGAGIAAGSEDAQTALMTLTLMVGVILLLARLARLGSIIENISDATLTGIKIGVGLTVAAGQLPKLLGVPADPAATGFLRVLWSALKHLGSANPATVILAAASIAGLYAMSKLLPRVPGPLVVVAVGIALVAFVHLDDHGVALISPVPSGIPLPGVPRLRDIGDLLPGALAISMMAFLETVAVGRGVRRASEPQIDSNQELFANGMASLAGSFFHTLPPAGGFSQTAVALRAGARTQMAAIVTAVLAVAVALFLAPVLDDLPQATLGAMVVVATLGLLDFGALALFWRVSRVEFWIAVGTAVVGLVMGLLPAVAVGVVATLYLVLRELNRPHVVQLTRGPDGRWVGGTPTAATEPANPLVLRVASGLYTANVRSNTEGIRRRVDELAAAGHPVHTVVLDCSWIPDVTLTVMRAFFDVVNELQDSGVTVYFAELPARNLATVRRTAVGRDLQQQGRLFSTVDRAVAALRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5C2</accession>
    <name>A0A231H5C2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pknB_3</name>
        <name evidence="9" type="ORF">B7C42_03564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44008">
        <property type="protein sequence ID" value="OXR44008"/>
        <property type="gene ID" value="B7C42_03564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="354" mass="38300" checksum="81D795E9A669682A" modified="2017-10-25" version="1">MERPQIDGGRYELVREIGAGGMGQVFEGYDSHLKRRIAVKLTHANLDQDPNWTKRFLREAELMAQLSHPGMPAIHDAGISPGPPERPYLVMEFIEGVTLDELLARRGPLPVGVVAALGAQAAAVLAATHRNRIYHRDLKPSNLMLCADGTVKVLDFGLAVTTDTDMTRYTNTGNTLGTPAFMAPEQVEGRAVVAQTDLYALGLVLHELLTGDRVMTGSSPYVVWQNQVHSAPAEIRRERPEVPVDMARLIMSMLAKSPDRRPEDAVTVHTVLMRHGNGIGELPEVGDFHGPARMYAEAVSAAVASPTVMASTKIIASEEKVAPPPRSSDSAAPISSGLSVVHATSPRNLAIHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5H2</accession>
    <name>A0A231H5H2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44144">
        <property type="protein sequence ID" value="OXR44144"/>
        <property type="gene ID" value="B7C42_03703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="16543" checksum="9C1A2B0E46DAF288" modified="2017-10-25" version="1">MKGSQPYPSRTVAIQTIQRELTAFARRARGRAAELHPELPLVAYSILDLVIARDGCLAAELAEYFVLDKSTMSRQVAALEKQGYLVKEVDPANRRNHVLRATPEGRRVAADSERARSAAVNERFRDWDDRDVAQLAAYLERYNAADGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5K5</accession>
    <name>A0A231H5K5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44169">
        <property type="protein sequence ID" value="OXR44169"/>
        <property type="gene ID" value="B7C42_03729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="163"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="714" mass="78980" checksum="1327A9B96B0A1DA4" modified="2017-10-25" version="1">MTPLGVWPGAAYPLGATYDGAGTNFSVFSEVAERVELCLIDRAGGEHRIPLDEVDGYVWHAYLPTVAPGRRYGFRVHGPYDPARGLRCDSSKLLLDPYGKAFAGTFTADATLHTYGADTLGHTMTGVVVNPYFDWAGDRPPRRPYHETVIYEAHVKGLTMTHPAIPRRLRGTYAGIAHPAIIDHLLSLGVTAIELMPVHQFLHDRILLDRGLRNYWGYNSFGYLAPHHEYAADPRAGAAVTEFKAMVRALHSAGIEVILDVVYNHTGEGNHLGPTIGLRGIDNAAYYRLAEDDPAHYMDYTGTGNSLNVRHPHTLQLIMDSLRYWILDMHVDGFRFDLAATLARELHDVDRLSTFFDLVQQDPVVSQVKLIAEPWDVGEGGYQVGNFPGLWTEWNGKYRDTVRDYWRGRPATLGEFASRFTGSSDLYEATGRRPGASINFVTAHDGFTLRDLVSYNDKHNHANGEDNRDGEDYNRSWNCGIEGPTDDPDVCALRDRQSRNMIATLALSQGTPMLLHGDEIGRTQQGNNNAYCQDSPVSWMDWGAAQKYADLLTFTRAAFALRRAHPVFRRRRFFDGRPGTPDELRGAGSDELPGAHAGDIAWFTPGGTEMTTADWNTGFARSLAVFLNGEAIAEPGPRGERVRDDSFLLCFNAHDAPLEFAVPGPEFGAHWTVALDCSTPTGRADATYSAATTVAVPARCLLVLRRSESTPISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Q0</accession>
    <name>A0A231H5Q0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777446.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44150">
        <property type="protein sequence ID" value="OXR44150"/>
        <property type="gene ID" value="B7C42_03709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="295" mass="30882" checksum="BFF4704E9757F251" modified="2017-10-25" version="1">MVLAVTLSALGVGCSDGTEATSDAEVEPSGFGKEVTLPISAAVATLVTPGEEPHAPLRPAVRPGTSQQVTLRTDHHVEQQINDQAVRDFSPPSVTIPLTADAKAEGVDLVLGTATSPDPALDQQLLGADGSHAGIEFTDLGAVTALRMAPAPSTPDTARAAIEQAFYQAVYEAIAFPADAVGEGAVWTVHQRVSGVVPLDQMTTATLTKREGNLLTIALDITQTPKSATWQLPNNSGDLDIIDYLMHGAGTITVDLGLPLPVSGAITIGGNQCYRDPHTDVLLRQDVRTQVRWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5R2</accession>
    <name>A0A231H5R2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitamin B12-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">btuF_2</name>
        <name evidence="3" type="ORF">B7C42_03738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44178">
        <property type="protein sequence ID" value="OXR44178"/>
        <property type="gene ID" value="B7C42_03738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059354" evidence="1">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="36713" checksum="16E7FCE83D169DC1" modified="2017-10-25" version="1">MQFLRWLAVGSTVASLVACGTAQTSGGNLTLTNCGEQVRFPAPAQRMFVNDTNMVAMTLALGAQDSVAAVAGLQQDVATLRRHYGDVVDRLDNVAPSSPSRETVLARRPDVMVAGWNYGYSEATDLTPDTLRANGIAPYILTESCRPHAGQRQRGTVEPWAALRADLSNLGAITGHPEQATTLVADIDTRLQRLRAAPRAATPPTLFVFDTASETIFSSGRFGGPQAVLEAAGARNALDDVADTWTAVSWERLAAADPDALVFVDYPGQTFAQKVDALRAKPGINRLRAVTEQRFLNLPYVLWTSSPLNIDAAEQVRAQLERWNMLPPSGIRPAFDDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H602</accession>
    <name>A0A231H602_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_3</name>
        <name evidence="6" type="ORF">B7C42_03752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44192">
        <property type="protein sequence ID" value="OXR44192"/>
        <property type="gene ID" value="B7C42_03752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="300"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="336"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="563" mass="60701" checksum="10CF4296A8183173" modified="2017-10-25" version="1">MTATTTALASDAGRAAPVAPLLAVRDLAVAYDGNLSAPTVSGVSFDVPAGAAVAIVGESGSGKSTVVNAILRLLDHGVAVGGRAEFGGRDVLRLPEREFRHIRGRRIGFVPQDPTSSLDPVRRIDRQIFEAFRASGLPEYARRSRLHAQAAELLDSVGIAQPERTLHSYPHQLSGGQLQRVLIAIAISQHPDLIIADEPTSALDVTIQKTILDLIDRLRAERGLSVLLITHDLSLAAERADRVVVLNSGRVAESGPSSAVLREPESGYARELIGDIPSIDPDRFAAAKAQRARPGGEPVLTVTDVHKTFRIGRHRTEALKGVSFDIPAGRTHALVGESGSGKSTLARVVLRLTEPDAGRVLVAGRDISHLGRRELRVARQNLQLVYQNPFQSLDPTYTVAQLVAEPLIRYRWGSRAQRRARVLEVLDLVGLDESLLTRGIRRLSGGQRQRVAIARALSLSPKLLVLDEPTSALDVTVQAQILQVLVDLQVKVGVSYLFISHDLSVVRQLADTVTVLRRGEVQEQGATADVFSSPSGDYTRRLVDSIPKPPGHNVVQLTSGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H663</accession>
    <name>A0A231H663_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">uvrA_2</name>
        <name evidence="13" type="synonym">uvrA</name>
        <name evidence="17" type="ORF">B7C42_03823</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44262">
        <property type="protein sequence ID" value="OXR44262"/>
        <property type="gene ID" value="B7C42_03823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="618"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="951"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="650"/>
            <end position="657"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR44262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="983" mass="107568" checksum="DDCA51914E3A0FA0" modified="2017-10-25" version="1">MADLLTVRGAREHNLKGVDLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITEVYDYLRLLYARAGTPHCPVCGELIAKQTPQQIVDQVLEMEPGTRFQVLAPVVRTRKGEFVDLFDQLNTQGYSRVRVDGVVYPLTEPPKLKKQEKHDIEVVIDRLAVKPTSKQRLTDSIETALRLADGIVVLDFVDRDEHAHDRERRFSEKLACPNGHPLDIEDLEPRSFSFNSPYGACPDCTGLGIRKEVDPDLVVPDPELSLNDGAIAPWSRGQTAEYFNRLLSGLSEAIGFSMDAPWNTLPLKARKAVLEGSSDQVHVSYTNRYGRKRSYYADFEGVMPFLQRRLESTESEQMKEHYDGYMRDVPCPVCSGARLRPEILAVTLNAEGGRRSIAEVCDLSIRDCSRFLNSLELGEREAAIAGQVLKEIQARLGFLLDVGLEYLTLSRAAATLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLRNLGNTLIVVEHDEDTIHSSDWVVDIGPLAGEHGGQVVYSGPYPGLLEDPNSLTGAYLSGREVIEVPLVRRPVSKKKQLTVVGANEHNLRGIDVAFPLGVLTSVTGVSGSGKSTLVNDILATVLANKLNGARQVPGRHTRINGLDHLDKLVQVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVKGGRCEACSGDGTLKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKTIAEVLDMSIEEAAEFFEPVTSIHRYLKTLVDVGLGYVRLGQSAPTLSGGEAQRVKLAAELQKRSTGRTVYILDEPTTGLHFEDIRKLLAVINGLVDKGNTVIVIEHNLDVIKTSDWVIDMGPEGGSGGGTVIAQGTPEDVAAVADSYTGQFLREVLEKPAAPKKTTKPKKATAAKAAAKPAGRRKAAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H684</accession>
    <name>A0A231H684_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775937.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44523">
        <property type="protein sequence ID" value="OXR44523"/>
        <property type="gene ID" value="B7C42_03312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="15017" checksum="5C627FDB9BC3B670" modified="2017-10-25" version="1">MTATTTTEHPARLAGRASQAAVRARDKDAWLALFAADGIVEDPIGPSVFDPEGVGHRGRDAIAAFWDKAIAPTESIDFVFGDSFACGSEVAFTGLIRTQLGGHVIDAEGVFTYKVDEAGKIVALRAFWETDRAMGTMRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6C8</accession>
    <name>A0A231H6C8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44342">
        <property type="protein sequence ID" value="OXR44342"/>
        <property type="gene ID" value="B7C42_03903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="24388" checksum="369BE2673C02105F" modified="2017-10-25" version="1">MIDIGTDSGLDFLDDRVRGVVERLEVAARADGEVIGAVSVRLRELGATPDAETLRVMTATGEAAMLPVARSVGRLLFQLALGSGAATIVEYGTSHGMSTLYLAAAARRTGARVIGTELSAHKAAVATANLAEAGVGDRVRVLVGDALETLPTVSGPVGLLLLDGWLPLHLPVFRAMEPKLTLGSIIVSDNVSRHADLLDDFHRYVAERSQTYLRTTLPLDDGIDVIVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6W0</accession>
    <name>A0A231H6W0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS-type transporter EfpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efpA_4</name>
        <name evidence="7" type="ORF">B7C42_03321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44532">
        <property type="protein sequence ID" value="OXR44532"/>
        <property type="gene ID" value="B7C42_03321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="475" mass="48333" checksum="7509D4BC5F6C2C4C" modified="2017-10-25" version="1">MSTRVSAPPSRRWFALALIALAQFMVIMDTSIIGVALPEMQESLGFSQEGLSWVFNAYVIVFGGLLLLGGRLSDIWGARRIFRTGWVVLGAGSLVAGLAGSPAVELIGRGVQGAGAALIAPSALTLLMMVFGSNPKELTTAFAFYGAAAPAGGTAGVFLGGLITEYASWPWVFYINIPIAALAVVAAAVLVPGGAAASGGSVDVLGALTATLGLGAAVFAVVRAPEVGWGSGSTWGVLALAVVLLAAFLVLQARRRNPLMPLSIFRAPNLGAANLAQVLLGAAWVPMWFFLNLYLQQVLGYSAFPSGAALLPMTALIMVGMIAVSPKLFARFGARAMIVTGLLVLGAGLVWLTFIRADGNFWIDVLPGSLAAAFGMSLAFVPSLQTAISAARPEQGGLASGLVNTGYQIGSALGLAVVTAIASAAGADRIGDADALTDGFSAAFGAAAGIAVLAAALAWATFRSPARRERVPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6X5</accession>
    <name>A0A231H6X5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775843.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44476">
        <property type="protein sequence ID" value="OXR44476"/>
        <property type="gene ID" value="B7C42_03265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="105" mass="11692" checksum="24F231614D17DE8A" modified="2017-10-25" version="1">MVSWAKAPDFADRPERREQVRAQTVVDKQRYLEDGLTPVACRACGVEVLVRKSSSHQRSVQWTVSPAEHCPVFAKLAGPGRPDPCPDLEKSIQYAIDEGMLAIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H704</accession>
    <name>A0A231H704_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44625">
        <property type="protein sequence ID" value="OXR44625"/>
        <property type="gene ID" value="B7C42_03419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="25543" checksum="EEFEC7C466F4CEF7" modified="2017-10-25" version="1">MSGSGNDSSSGDEIPAWKRRTAGESRWAATAAMVGIIVLQLLLPHHFQLRPIWLLPLLEVLLLIVLVVSSPVRLDREEIWLRWCGLAMSALLGIATAWSVFRLVAGLIDGTLSNDPPVLLGSGAAIWLTNVTVFALWYWEFDRGGPAARAHAREPLPDFLFVQMQNRDLAPADWEPEFLDYLYLSFTNATAFSPTDVMPMTRWAKTLMMAESALSLITAALVIARAVNVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H726</accession>
    <name>A0A231H726_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44526">
        <property type="protein sequence ID" value="OXR44526"/>
        <property type="gene ID" value="B7C42_03315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="79"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="240"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="36579" checksum="D5F4042D13FB18F8" modified="2017-10-25" version="1">MTGVIAKGSGPEAEPAPEVLSAELRMKFDYTRSVGPTIGRFLTGLREGRIVGVRGSDGRVIVPPAEFDPVTAERLTDFVDVSDVGTVQSWSWVADPLPGQPFDRPFAWALVKFDGADTAVLHVLDVSSPDEVHSGLRVRVRWADERTGSIHDIACVEPGETSSAPAGSTSSATDAAEPVTGIITPIDLRYKHTASPTETRYLKALAEGRLIGGRADAESKVYFPPRGADPIDGRPTDEMVDLPDTGTITTFCIVNVPFMGQKIKPPYVTAYVLLDGADIPVLHRVLGCDPSEVRMGMRVKAVWKPREEWGYTLENVDHFEPNGEPDADYDSYRHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7E2</accession>
    <name>A0A231H7E2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenoxybenzoate dioxygenase subunit beta</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pobB_1</name>
        <name evidence="7" type="ORF">B7C42_02900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44943">
        <property type="protein sequence ID" value="OXR44943"/>
        <property type="gene ID" value="B7C42_02900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="285"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="39935" checksum="82C176925955D84F" modified="2017-10-25" version="1">MTTRRPVPAELPPDLYGGHGSDRPIRIIGAVAEARMRWASLIHRRPVTGAVDSGRLRVRVVERRIEAHDADVVSLVLRATDGNALPTWRPGAHLDLELPSGRLRQYSLCGDPADRYHYRVAVRRIPGGLGGSVEVHDELGVGAEVTIRGPRNAFPFVLPGHGSSAARVHFVAGGIGITPILPMVRMAHRLGVDWTMVYTGRSRDTIPFLADIESFGSRVTVRTDDDGGLPAAADLLPGVGVDTSVYCCGPVPMTSAIAAAVRDMPGVELYSERFSAAPVVDGKPFRVELARTGEVLDIPADRSVLDEVLRVRPDIAYSCRQGFCRTCKVRVLDGQPDHRDTVLTPGERADGELLICVSRCAGERLVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7T7</accession>
    <name>A0A231H7T7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44817">
        <property type="protein sequence ID" value="OXR44817"/>
        <property type="gene ID" value="B7C42_02771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022480">
        <property type="entry name" value="F420_MSMEG2906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03856">
        <property type="entry name" value="F420_MSMEG_2906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="29231" checksum="EFACF2826698C9B1" modified="2017-10-25" version="1">MPTANPRPIRIGVQIAPQHVDYPAIRSAAAQAEDIGVDIIFNWDHFLPISGDEHGKHFECWTMLAAWAEQTSRVHLGPMVTSVSFRNPDLVADMARTIDHISGGRMLLGIGAGAMERDFAEYGYDFGTPTARLQTLADALPRIEQRFAELNPPPTRKIPVLIGGGGEQKTLRLVAQHADIWHWFSSGAEFARKKQILIKHCADIGRDPREIELSAGVQGDPELVGAELLEQGVTTFTLEVHGPDFDMSVVRAWVAWRDKLADRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7U6</accession>
    <name>A0A231H7U6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44796">
        <property type="protein sequence ID" value="OXR44796"/>
        <property type="gene ID" value="B7C42_02750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="27345" checksum="7EE0FA90EB5E66D2" modified="2017-10-25" version="1">MNVEPSIQAKLLDLAAVDAELTRIAHRRKVLPEQQEVQRLEAERTDRKDAAVKVEIQLDDLDRDIRKLEGEIDAVRKREARDRGMLEGGNVGAKQLSELQHELGSLERRRGVLEDELLEVMERREAAEADHQHAGANLSRAEEDLILAQSRRDDAVADLDVAAQRCGTDREQLLAGFPDELLAIYDKQRAQHGVGAALLQARRCGACRIELDRGEIARIAKTDPQVVVRCPECGAIMVRTKQSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Y7</accession>
    <name>A0A231H7Y7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44958">
        <property type="protein sequence ID" value="OXR44958"/>
        <property type="gene ID" value="B7C42_02915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="32660" checksum="63A48570BAC44916" modified="2017-10-25" version="1">MGSGSTLAQRALGRELRRLRNAKGMGQSQAARIAETSHQTIGRIEEGQTTRITSLQVNALCDSYGASDEERRICLDLVKEIRASREGKVTASWWRAYADQISTGFNHYLALEDAADRLTIWKTTIVPGLFQTPDYRRAIAWAEYPEIPGAQLERRIEWQTHRQERLQDVNLRVSALLHEAVLCDQVGGQAVHSDQLRHLVNLAALPNVCIRIVPFVASSPLGSVAGPFTKLEFPDLPQSGLAQPPIIYVEGWAGDLYLERDAELQRYSQALRDVDRVALSPADSVALIKEHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H828</accession>
    <name>A0A231H828_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">drrA_6</name>
        <name evidence="6" type="ORF">B7C42_02966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45009">
        <property type="protein sequence ID" value="OXR45009"/>
        <property type="gene ID" value="B7C42_02966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="35713" checksum="8248881D619DA34C" modified="2017-10-25" version="1">METTATVRDRTRTSAIRVRGLARTFTTKTGPVRAVNGLDFEVREGEIVGLLGPNGAGKTTTLRMIATLLAPTAGEAQIADADLRRAPREVRARIGYVAQGGMTNDEELVIDQLVLQARLFGLGKAQATESAEHLLRTLELDGLGRRRCRELSGGQRRRVDIALGLVHRPRLVYLDEPTTGLDPQSRANLWDHVRRLRSEGTTIVLTTHYLEEADALCDRILVMDHGGIVASGTPDELKQRISGDVISLDIADAQADLAIEIADSVLELRSKLRADGLVHLTVARGDAAVVPLLRALDEHGIVPGALTVKRPSLDDVFLTVTGRSLREGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8C5</accession>
    <name>A0A231H8C5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-lysine 6-transaminase</fullName>
            <ecNumber evidence="4">2.6.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lysine 6-aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lat</name>
        <name evidence="9" type="ORF">B7C42_02398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21200"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="EC" id="2.6.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.36" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45273">
        <property type="protein sequence ID" value="OXR45273"/>
        <property type="gene ID" value="B7C42_02398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045484">
        <property type="term" value="F:L-lysine 6-transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017657">
        <property type="entry name" value="L-lysine_6-transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03251">
        <property type="entry name" value="LAT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="456" mass="50058" checksum="1F667F018C410F24" modified="2017-10-25" version="1">MGVTLELERPGTADAEVTNPASVTASRVHDILSAHMLADGFDLVLDLRKSRGRDLVDARDGTVYLDMFGFFASSALGMNHPALAANARFRAELTTAALNKPSNSDIYTVAMARFVDTFARVLGDPALPHLFFIDGGAMAVENALKVAFDWKSRHNAMHGRPADLGTKVLHLTGAFHGRSGYTLSLTNTDPIKTERFPVFDWPRIETPYLGPGVDIEAAERRALAQARAAFAENPHDIACFIAEPIQGEGGDRHMRPEFLRDMQELCHEHDALFLVDEVQTGVAMTGSTWAYQQFGLRPDVVAFGKKTQVCGIMAGGRVDEVPDNVFAVSSRLNSTWGGNLADMVRARRILEVIEAEDLAARAKELGALLRDRLRELADRHERLTDPRGRGLMCAVTLDSAELRDAVLAELRQRERVLFLGTGECGIRFRPPLTVTADELERAVDALDRVLAGMADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8N9</accession>
    <name>A0A231H8N9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inner membrane protein YdcO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydcO</name>
        <name evidence="2" type="ORF">B7C42_02350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45225">
        <property type="protein sequence ID" value="OXR45225"/>
        <property type="gene ID" value="B7C42_02350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042925">
        <property type="term" value="F:benzoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004711">
        <property type="entry name" value="Benzoate_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30199">
        <property type="entry name" value="PTHR30199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03594">
        <property type="entry name" value="BenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00843">
        <property type="entry name" value="benE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="421" mass="41960" checksum="A33202948F8665E5" modified="2017-10-25" version="1">MTATADSASHPPDVAEAQTGLQAAIADEHGSGGTGQAMSAGIIAALVGFTSSFAVVLAGLTAVGATPAQAASGLLAVCVTQAVGMWILSRRYRMPITLAWSTPGAALLAGAGAVTGGWPAAVGAFVVTGVLIVLTGCWSRLGRLITAIPVEIAQAMLAGVLLPLCLAPLRALTTSSAAVVAPVLVVWVVLQRYAQRWAVPGAFVTAVAGAAIAMVAGHRSIPAADLLPKLEITVPHWSWQAIIGISIPLYVVTMAAQNIPGVAVMSSFGYRVPWRASMTVTGLGTIVGAPAGGHAINLAAISAALAAAPSAHPDPHRRWTATMAAGGCYLVLAPAAAALVALAAAAPAGVLETVAGLALVGTFAAALTAALGVAEHRVAATVTFLVSASGIAVFGIGAAFWAVVAGLVVRWMLTRRDAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H902</accession>
    <name>A0A231H902_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776659.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45329">
        <property type="protein sequence ID" value="OXR45329"/>
        <property type="gene ID" value="B7C42_02454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="173" mass="18631" checksum="F1524E46D0891056" modified="2017-10-25" version="1">MAETMSLSQFLAPAAGSDAAAARQNGRAHRAAAGPVLGALDVDAGPFSGVRFQVPDGFIARELRGTKMRTTAGVFDEFAAALQFPYYFGDNRDAFDECLRDLDEFVGEAPGYVVVIRDSSGLLADQREDLEWFADAMTQAAEYWAGHGTVFRVVLQQHPAVLSPVELTMADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H909</accession>
    <name>A0A231H909_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase-associated protein RapA</fullName>
            <ecNumber evidence="3">3.6.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rapA_2</name>
        <name evidence="3" type="ORF">B7C42_02341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45216">
        <property type="protein sequence ID" value="OXR45216"/>
        <property type="gene ID" value="B7C42_02341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="479"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="782"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="955" mass="104538" checksum="28481F674C1742DB" modified="2017-10-25" version="1">MEDMLHGLWSPGSGLVLWRLPESAARPEEEAFGELPDPLGAIARSARFRHRVRVLVPGGAGPEVAEVRGHALAPEVAARVLTQALPETAVAADLRFLAHVALGLRRWVRAGRIVPELHRADGEWWVRWRLVGGQRQRAWLAELAAAMPPALRVPDARSAASILEDFVTELADPLVRLELSVREPSHPLTAALVAEVPLESGSHRVASVLDEWRASLTVGEPELVLRLLEPDDDPDDDPQAVDALWRLEVCLRSEGEAPQPVPIQGDPALIRLAGEKVAAAVQAYPRLQQVPRDPYGMDFLLPTPVVQELVAHGAHELRSAGVHLMLPRAWRIVSPSMRLRVQSPAATETAVGLSGLVSYRWELALGDTVLTPAEMGRLIQAKSDLVRLRGHWVQADQRSLAAAAAYLEGKVDERPATLTQLLGEIAATQVRQVPIEEVTATGWVEELFDGVRSGDPVDPPAGLKAQLRPYQLRGLSWLATMNRLGCGAILADDMGLGKTVQVLALLLHENESAATDSVPGPTLLVCPMSVVGNWQRETERFAPGLRVLVHHGSSRRSGAEFDAAVADSDLVLTTYALLARDVEELKRQPWERVVLDEAQHIKNAATRQARAARAIPARHRLALTGTPVENRLEELRSILDFAAPNVLGKPSEFHARFAVPIEREHDENAVSRLRAVTAPFVLRRVKTDPSVISDLPEKFEMTVRANLTVEQAALYQAVVDDMLAQLKASRATGSSAVNMARRGAVLAALTRLKQVCNHPAHFLGDGSALLRRGRHRSGKLALVEDVLESVLAEGERALLFTQFREFGDLITPYLSERFGTAIPFLHGGVAKKRRDGMVERFAEADGPPIMVLSLKAGGTGLNLTAANHVVHLDRWWNPAVENQATDRAFRIGQRRDVQVRKLVCVDTIEERIDDMLTGKQELANLTVGTGENWITELSTDELRDLFMLGAEAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9G4</accession>
    <name>A0A231H9G4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45471">
        <property type="protein sequence ID" value="OXR45471"/>
        <property type="gene ID" value="B7C42_02596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="3">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="322" mass="32620" checksum="6A79C752A7529DAE" modified="2017-10-25" version="1">MVEPPGDGFTGVVWEARPTERLARELTTGPGSVPMAEAASAWGRLAANFGAAVLDYDRIVSDIRGHWQSDRSDEVLERIARMRDWLLDAATAAGRNATHAAEQAAAYEVARLAMPHIAEIAALEQATHTVQAIGAAMGAPLVGAAADISADQDVAKAGAARVMRTYEAATEPLALPWQQLEPPVLATGDALAGEQAAAAVAAESAPAMPAIAGMPAMPNPAAFEMPRTLTGTRVQTVARAAQTTEFTALQSSPTQTGTAAGQAVPAAAGPAAAQSQEERTARAGMADAPGVGEFELEAGFAAAPAVLGGVEASPATGTASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9J3</accession>
    <name>A0A231H9J3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YtcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytcD_5</name>
        <name evidence="2" type="ORF">B7C42_02626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776499.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45501">
        <property type="protein sequence ID" value="OXR45501"/>
        <property type="gene ID" value="B7C42_02626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="14574" checksum="3F23D79B0C5D38EF" modified="2017-10-25" version="1">MTVGSQPGHDAWRGISDAFNTECPARELLEHITGRWGILILAALGAGPRRYSELHATIGGISEKMLSQTLRALVRDGLVARTVEPSLPPRVTYDLTPLGRGLTESMQPFLDWIRAHTAQVVTAQRRYDRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Z2</accession>
    <name>A0A231H9Z2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45669">
        <property type="protein sequence ID" value="OXR45669"/>
        <property type="gene ID" value="B7C42_01961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="28666" checksum="B31467425932FE22" modified="2017-10-25" version="1">MADLGDHATRPYQEETVTRRTSHRRRCHEAVNTCAATHVVRANRSSGGTPSSWFRTGAPSEELNGVLRIGDASPHEIERLRTLVDGVPASWHFWRDVDSPEIPDLLRRTGLALFETEPLMMLADPGRVVNGERDEPERIETVTDDGGLAEWAGLWSGATDVAALVAGLRQGMDRGSTRYLLWREGGEVLGCAAVVTSAAGASLEHIVTRADRRGQGIGSALTRHALDLALEAGARRVVLTASPDGEGIYRRLGFVTVGHVERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA17</accession>
    <name>A0A231HA17_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776461.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45557">
        <property type="protein sequence ID" value="OXR45557"/>
        <property type="gene ID" value="B7C42_02682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="17384" checksum="987179CDB6E8FA22" modified="2017-10-25" version="1">MSTETATYRGWKKLPDNRLGHALFSVGMIARVPYFGTVVPNVVRLEPGLCEVTAPKWFGIHNHLGTFHAIAACNLAEVAMGMLSEATVPTTHRWIPKAMNVQYLAKAESGLRAVAKLDRIPDFDTLTEGTEVVVPVSIYDKRGVEVVHADITTWVTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA61</accession>
    <name>A0A231HA61_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator YvdT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yvdT</name>
        <name evidence="5" type="ORF">B7C42_01994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45702">
        <property type="protein sequence ID" value="OXR45702"/>
        <property type="gene ID" value="B7C42_01994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="217" mass="24436" checksum="93B01EC297E53FF1" modified="2017-10-25" version="1">MSSPSEEPAWKQRAVERSIRTAKLRAEQRVQRFLDAAQAIITEKGTTDFTVQEVVDRSKQSLRSFYLQFDGKHELLLALFEDALSRTADQLRAAADGQDDPIDQLRVTIELLFELSRPDPTAQRPLFTDFAPQLLVSHPAQVKVAHAPLLSLITELMEKAQEQGRLRKELNARRTAAMVMQTVMFTAQSTGGTDEETTHPITAEEVWNFCAHGFAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAB8</accession>
    <name>A0A231HAB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-N-acetylmuramic acid deacetylase PdaC</fullName>
            <ecNumber evidence="2">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdaC</name>
        <name evidence="2" type="ORF">B7C42_01969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45677">
        <property type="protein sequence ID" value="OXR45677"/>
        <property type="gene ID" value="B7C42_01969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="45"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="26092" checksum="CAADDCE93A5DC30F" modified="2017-10-25" version="1">MKSVVAHAATAGAGAVLLNALPSVTAISTLRTRLTPGLSGYSETDTVALTFDDGPDPESTPAILDALAAAHVHATFFLLGSMLERAPALGAEIVAAGHEVAVHGWSHRCLLARGPVSTYRDIARGYDVITATTGSRPRHYRPPYGILSAAALATARRLGLAPVLWTACGKDWVRTATPDTVARRVVRELRPGATVLLHDSDCTSASGAWRATLGAIPRIVDECAERGLVVGSLAERTPIARHAPRSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAP7</accession>
    <name>A0A231HAP7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821332.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46024">
        <property type="protein sequence ID" value="OXR46024"/>
        <property type="gene ID" value="B7C42_00987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011314154" evidence="2">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="14118" checksum="4B94086ED48DCE9F" modified="2017-10-25" version="1">MKRLTVTAVALGALTVALTGCGGDDHSSADANGLRRNGSAVATSASAPASTTPAPAPPTEAPGTTAHPESSGLGPASATTCDEFRKLDIEGEKSLMDRILAENPGSKFDGSPNVALGTAKLVCLSKSEADKPVALAIGMVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAX3</accession>
    <name>A0A231HAX3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043351.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46083">
        <property type="protein sequence ID" value="OXR46083"/>
        <property type="gene ID" value="B7C42_01047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="78" mass="8254" checksum="06724AAE7851B988" modified="2017-10-25" version="1">MTAQPSSASPSIPVGVTVNGTDHVFAEPLTVRELLERLDLPCRGVALAVDGALFPKSRWDEPVGRGWEIDVLTAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBB7</accession>
    <name>A0A231HBB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadI_1</name>
        <name evidence="6" type="ORF">B7C42_01200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46234">
        <property type="protein sequence ID" value="OXR46234"/>
        <property type="gene ID" value="B7C42_01200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="302"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="445" mass="47043" checksum="F22BFE14CEC45449" modified="2017-10-25" version="1">MTTKARSAKTAPSSSRADKAKQAKPVAVLGGNRIPFARSDGRYAHASNQDMFTSALNGLVSRFGLQGERLGMVVGGAVLKRVGEHGMVRESVLGSELSPYTPAHDLQLACGTGLQSIVTVGDAIALGRIEAGIGGGTDTTSDAPIGVSESMREWMLDANRARNNKDYVKLVGRLRPSMVGIEIPRNAEPRTGLSMGDHAAITAKEFGIAREAQDELAYLSHKNMAAAYDRGFFDDLVTPFLGLTRDDNLRPNSSLEKLATLKPVFGNKLGDATMTAGNSTPLTDGASAVLLGSEEWAAERNLKPLAYLVDSEVAAVDYVWGPDGLLMAPTYAVPRLLARNGLTLQDFDYYEIHEAFASVVLATLQAWESDQYCKERLGLDGALGAIDRTKLNVNGSSLAAGHPFAATGGRIIAQAAKQLAEKGSGRALISICAAGGQGVVAILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCA1</accession>
    <name>A0A231HCA1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775078.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46510">
        <property type="protein sequence ID" value="OXR46510"/>
        <property type="gene ID" value="B7C42_01480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045522">
        <property type="entry name" value="DUF6474"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20079">
        <property type="entry name" value="DUF6474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="213" mass="23179" checksum="F2DDD31ECAF822F6" modified="2017-10-25" version="1">MGLFTKRKRRADRKAEAKALKHKAALEAKLGARNERKRQRAELRTQRDVAKAQIAALKAEEKAALKTAERADRELLTASQVKKYLGVARVLVPVLAPLAYRAATFVRGQIDTRRAHRLGIGLGDLGNFTGHGARLQARITGVESTLAGIENSGDKSGETQKFVAATRDRLASLSAAVRTAEQMPAPRRRAVHNSISHELSGVEADILARLGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCC5</accession>
    <name>A0A231HCC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PP2C-family Ser/Thr phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pstP</name>
        <name evidence="4" type="ORF">B7C42_01451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46482">
        <property type="protein sequence ID" value="OXR46482"/>
        <property type="gene ID" value="B7C42_01451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="494" mass="51431" checksum="308113747A3A7490" modified="2017-10-25" version="1">MTQVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLMIAALAHLDDDEPGDDLLGKLDRAIREGNAAIADQVEEEPELDGMGTTLTTILFAGKKLGLAHIGDSRAYMLRNGELAQITRDDTFVQSLVDEGRITPEQAHTHPQRSLIMRALTGNEIEPTLIVREARAGDRYLLCSDGLSDVVSDETIANTLREGNTDEAADRLIELALRSGGPDNVTVVVADVIDLDYGQSHPIVAGAASGEDEDTPPPNTAAGRAAAMRPPRAAPRRAAVAAEPPEPRKSHKGRWIALAVALVVAVVVGLVVGYKMIRSNYYVGADNGNVVIMRGLPGSVLGYSIQDVDQLVCVDSRNKVTLMRPGAGFPSGCKQLAVADLQQTGRDKVNNGLLPPGGFDSTRGQLEKLAATDLLPVCAKPAPPVAPPPAEGSTAAPGSPAPATPAPSPAPNTPGTSAPNPTNAPAHSEQPAPTTAAPAPQTPGENCRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCM4</accession>
    <name>A0A231HCM4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46427">
        <property type="protein sequence ID" value="OXR46427"/>
        <property type="gene ID" value="B7C42_01393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="22347" checksum="F93D4C89367E6752" modified="2017-10-25" version="1">MTENPPPGNYPPPEPYPQSGGEPGRSGEYPGRSGEYPGHSGEYPQQPGQYAQQPGQYGQQPGQYPGGYPPPPPGGYPGPPGQGTWEQPKGKGLAITALVLGIIAVLTCWTVLGGILFGLVALIFGIIATVKARRGTAAGGGMAMAGLVLGLLGLIAGIVIAAIGVNFFVNNGGKDFLDCVNKANGDQSKIDQCQRDWNQTLENKYSVTLSPRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCP2</accession>
    <name>A0A231HCP2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yidD</name>
        <name evidence="3" type="ORF">B7C42_01413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46447">
        <property type="protein sequence ID" value="OXR46447"/>
        <property type="gene ID" value="B7C42_01413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="13201" checksum="023AEE3C917D6FB9" modified="2017-10-25" version="1">MNRLRVVTRLPANLVIFLIELYRTYVSPTRMPVCRFTPSCSEYAVTALRTRGLVVGLGLTAVRLAKCAPWHPGGWDPVPERKRAAAEAAHETSRAHDEAAEHKSCKGSPRAVTGDTTDGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCQ9</accession>
    <name>A0A231HCQ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46701">
        <property type="protein sequence ID" value="OXR46701"/>
        <property type="gene ID" value="B7C42_01676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11644" checksum="9B99374A5FF55F4E" modified="2017-10-25" version="1">MRDRPIGLGWVHPEAAAPDWDMAQVRRLASRLGYRLVWAPETSRIPLADQVREVGAEAVIAPSTAHFDPLTLNAVMMVADVETVLPRLSFARWATRSPYERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCT7</accession>
    <name>A0A231HCT7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-Q tRNA(Asp) synthetase</fullName>
            <shortName evidence="5">Glu-Q-RSs</shortName>
            <ecNumber evidence="5">6.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">gluQ</name>
        <name evidence="8" type="ORF">B7C42_01711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46734">
        <property type="protein sequence ID" value="OXR46734"/>
        <property type="gene ID" value="B7C42_01711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01428">
        <property type="entry name" value="Glu_Q_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022380">
        <property type="entry name" value="Glu-Q_tRNA(Asp)_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03838">
        <property type="entry name" value="queuosine_YadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="7">
        <location>
            <begin position="16"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutamate binding" evidence="5">
        <location>
            <begin position="16"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="5">
        <location>
            <begin position="244"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="312" mass="34092" checksum="0F83AA5DE921022F" modified="2017-10-25" version="1">MSPAARMIPHTAGAGRFAPSPSGDLHLGNLRTALLAWLFARSTARNFRLRIEDLDRVRAGAEQRQLEDLAAIGLDWDGEVVRQSDRTARYAAAIERLDAAGMTYECYCTRREIQKAVSAPHGPMGAYPGTCRDLTEAQRAAKRAEGRPAALRLRARTTEFEITDEIHGRYRGLVDDFVLRRGDGTAAYNLAVVVDDAAQGFDQVVRGDDLLPSTPRQAYLATVLGFAVPAYAHVPLVLNTDGARLAKRDGAVTLRDRIALGETPRQVFTMLAASLGLRGETPRALLDQFTPATVPHAPWILDPAHPDPLRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCU2</accession>
    <name>A0A231HCU2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46616">
        <property type="protein sequence ID" value="OXR46616"/>
        <property type="gene ID" value="B7C42_01587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="18148" checksum="B3D90EDDD6AB1020" modified="2017-10-25" version="1">MAYEPSGPPASTPWLSSAQQRAWRAFMDGHQRLMVELNRQLQADSDMSLPEYRILVMLSEAPGGSLRMSDLADGVLSSRSRLTHQIRRMEDEGMVRRTSCEEDGRGVRAHLTEEGMRRLRAAAPGHVAAVRRTFVDLLSPEELTAIGDAFDRVNAKTDPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD34</accession>
    <name>A0A231HD34_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46617">
        <property type="protein sequence ID" value="OXR46617"/>
        <property type="gene ID" value="B7C42_01588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="10659" checksum="7039CFEB35F30F94" modified="2017-10-25" version="1">MTMTPTGGSVGATIVSVSIRTAGAEVQKHHTQSADPGSGMVMQMAIGFAVVSEALSAEAMGAATAPSDKMIAVVARAFADFLCMVRTFRRAPSKGNRKARSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD42</accession>
    <name>A0A231HD42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phthioceranic/hydroxyphthioceranic acid synthase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pks2</name>
        <name evidence="11" type="ORF">B7C42_01699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46722">
        <property type="protein sequence ID" value="OXR46722"/>
        <property type="gene ID" value="B7C42_01699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="7">
        <location>
            <begin position="4"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="9">
        <location>
            <begin position="528"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_DH" evidence="8">
        <location>
            <begin position="889"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_ER" evidence="10">
        <location>
            <begin position="1416"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_PP" evidence="6">
        <location>
            <begin position="2031"/>
            <end position="2088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="2108" mass="224557" checksum="D001EDD790C3676E" modified="2017-10-25" version="1">MSDIAIVGIGCRYAGGIDSPESFWDFVINKRDGVTEIPADRWDWRRYYDADRRTPGRMYTKRAAFMTGDPWEFDPDFFGISPREAAAMDPQQRLVLEVVWEALDDAGVAGRSAGSGLGVYIGAFTLDQLAVSVGGPALPHVDMHTAAGASYTMLSNRIAYALNLTGPAVTVDTACSSSLVALHLACQAIESGDCEYALAGGVTVMAQPEPFVSMCKGGFLAADGRSKPFDAAADGYGRGEGAGIVVLKKLADAERDGDRIYAVVKATGSNQDGRTTAITVPNADSQEALAKTVIERSGIPAHEITYVEAHGTGTPVGDPLELRAIGRAYGAATGRPGPVGVGSVKATLGHTEAASGIASVIKSALAITHRTIAPQGWLDTPNPDIPFEELGIRLQTEAEPVGPEVERMTVAVNGFGYGGTNAHAILQEYAGAPETGRAPQHFGVLPLSARNETAVRHLARGVAELIAEGADPGRLAEAAWRRRNHHNHRAAITFGDDTELVRGLVDLANGEGRISRTVAKRTAEPVYVFTGMGPQWWGMARELLTTDTAFADEARRIDAVFTDIAGWSIVEELLRPEEESKVTSTAIAQPANFLVQVALYAALREYGIEPAVVVGHSVGEVSAAYVTGMLSLRDALLVSYHRARLQATTAGTGGMLAIGLPADAAREVIAADSSVDIAAINSPSAVTLAGAVDRLDEIAEKLTADGIFARRLQVEVPYHSHLMDPILDELREVLAGLTVAEPRIPLYSTVTGEQVTTADWNADYWCANVRQPVRFADAITALVRSGNRVFVEVGPHPVLGANIREILIGAGETGTTVATLHRKQQDADSLRQTLSGLYAAGILDIDALFAGVPDPTPHIDLPRYPWQRTRLRNELPEFRLLRHGTPDAHPMLGDQHPDDSNAWRVELSLAALPWLADHVVGGTRILPGAGYLDAALSAAAVRTESDQVAVEGVRFVAPLVVEEGEAPIVELHVEDSTGRFTIRSRGAAGTIWTVHALGRLVEGSYAPITADVPDVEHMLAVDPAEFYAGLAARGLEYGPAFQRATAIRISPDTVVAQLDGTIGQGERYLAHPAIVDAALQSVAALLAGRGGAQEGAMVPVGVRTVRRLAPLPAEVTAVARFTEGDRPLADIDLLDADHTVVMQIRGMEFGSLTPGRGPLQRMTDMFYEERWELRDPVDTTALPGNDGLYTLVLGYGENIDSRIERVRDAVAGGAGSAVLLLDPADAELEPRLAQQLRDIFGDEDVRRLHVCVVPGHAPDGDVAALWTLRRIAVTLDGYLEERVTEHEIEIPLTGDGSMYATVVSAHAYAHPADETAPDPSQAAIAGARRVLLNEQSRLRWRLVDIDADTTVADLSAELAIPGGFQYDLVDEAVLRNGLRWTTVVTRTLPERLDALDTAEPLTDPEANFELELPRSRTFARLGWRRCDRREPGPGEVEVRMRAVGLNYKDALKVIGVLGERELSETFFGLVPGMEGGGEVVRVGPGVTDYAVGDAVSLTSKGMVARYHTTSTDSLTHVHPDTDAGRCSSVTAFTTAEYSLLELARIRAGETVLVHGAAGGVGSAAVQIAKLHGATVIGTASSEERRAYVLAEGADHAVGSRSLTFVDEVLALTGGRGVDVIISSAPGEILRQNFAVIAEFGRIVEIGKADIYTGGMLDLSAFDKNVSYFSFDLDRMLRLRHTEVMELGRKVNASFDNGTYRPLPFQKYGTAEVAQAFEEVARSTRIGRVALDLTEGQPLVRPQLPDIEIDPAAQYLITGGFGAFGLATGRWLVGHGARRLTLLGRGGATTEAAVAQLAAWEAQGIEVTIERVDITDADAVAAVVARAHRPEHPLRGVFHTAGAIDDKRITVMDAESLAKVFRAKADGARALVAGVQAAGARLDQFALWSSGSAMFGGVGQYAYTAANIALQAIGDSVIRAGGTALVVGWGHMSGGGMADDEHIARYLRNTGFDSITMDEGTEYLEQALRLGVTQASIIPVDWAKVNATAPFFAQTGRTKELIAAAAQDDSAAARLRVQLAELDEGKRNEVVAFMLAEQLAQVMGVSADSIDLTVPVPELGLDSLMAVEFGALVTKSLGVELMSMKMGRSFSLEQAGARVAEAIVQGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE61</accession>
    <name>A0A231HE61_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Group 2 truncated hemoglobin GlbO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glbO</name>
        <name evidence="3" type="ORF">B7C42_00186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030512691.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47066">
        <property type="protein sequence ID" value="OXR47066"/>
        <property type="gene ID" value="B7C42_00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="15564" checksum="651D82F076D2E1DD" modified="2017-10-25" version="1">MTSGEQTATSFYEAVGGAETFRRIVAAFYREVAADEILRPMYPEQDLGPAERRLRMFLEQYWGGPRTYSDERGHPRLRMRHMPFSIGPLQRDAWLRCMHIAIAEIEPDVLDDEHRRALLDYLEMAANSLMNSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEE4</accession>
    <name>A0A231HEE4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein HscA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hscA_1</name>
        <name evidence="4" type="ORF">B7C42_00386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47264">
        <property type="protein sequence ID" value="OXR47264"/>
        <property type="gene ID" value="B7C42_00386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="797" mass="78014" checksum="8C38AD01B7B3B58D" modified="2017-10-25" version="1">MTVGFGMSIGTVNSVWAATAGDRDRPAVRVRRTAVTVDRSGAVRVGGMPRFAPVATDFADLTQAREPVSLGGRIRSSADLVAAAATSLIDASDPEAGPVLTYPACYTDRQVAALQYALHRRGAFEVILMPEPVAAVEWLDDEYGVTASSSTLVYDLGANSLDVAVVRTEAEWNQRGVLGSALRSDAFGGRPLGAVLARYARTLAPDVPAPVSKVVPAEDTRRLRTWHVRNSLGVVRDCLKSARVTIDDVDRVLLVGGAARPVEVAEVLAELGPPVIVPPDPAHTVATGAAIASARFATSNSNVGRYARGAAVVSSAAVVSALAMSAATMIGGGPVGTDGPVMEFAPALAGPAEALREQVGELPQTPGFGAGFAALAARADTLMGTSLSGLRGYAGAAHDFSRSMTDRVENALHDYGAVTPCVPPRARTYSDPARFTNPMPFVNSGAAALLAAGAAARDLPGAGHPGQPGSGDQGTPPGGGSTPGDSSKPGNPAPKPAGTPDGSITPGTNPAPAGDATATTGATPGDSHSGEAASTPGSGHSSGTADSGAGSGADSNPAGGSSTSSNGSASTSAESHGAHGSANSGGTQNSGAGNSGTESSGTENSGTQNSDTQNSGAANSGAAHSGDATNSDTGSNPGGAGTSGDGTNSNGTANTGDHAKPGSPAPGGGGTDSAPAAGAQSGPGTSSSDTVPGAGTARTPGGGTATPPGGATRPGATNPAPAPPFTPASSRRATPAWVPPPAVASTADWAVVGSVAVSTRAVSVTDTVRRAGPATDAGPATTRLCADPGRRDSAGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEM0</accession>
    <name>A0A231HEM0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prodigiosin synthesizing transferase PigC</fullName>
            <ecNumber evidence="3">6.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pigC</name>
        <name evidence="3" type="ORF">B7C42_00297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47175">
        <property type="protein sequence ID" value="OXR47175"/>
        <property type="gene ID" value="B7C42_00297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="811"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="893" mass="96710" checksum="883A08F2B600B9D7" modified="2017-10-25" version="1">MHESEAGPAEAADAGGKAAGLRRLRDASLPVPDWLVVEPAMFEHMPAEIVTAAAEFVRAADLDEALTRGARLRASIMTATPPDALVAAMEEVWQRLGRAPVAVRSSAAVEDGTAYSFAGQFDSFLNVSGAEAIASVVTACWASALSPRLINYCFAHGLALPEMPAVVVQRLITAETSGVLFTCDPSTGATDRMLISAVYGLGEGLVSGAVDADTFVVDKFSGTAIDTVLGEKATRYRPDGGQGCIAVDVDPALRARPALTPEQVTRLIEVGRRIETATNGPQDVEWAFDAEGRLWVLQARPVTTAVGDPLRGAGEAVPDGELRIWDNSNIIESFSGITSPLTFTTAADIYGRVYRGYAESLGVPPSQVAQTDSWTPVLLGYFHGRVYYNLLHWYRMVGIAPGYPLNRRVLEAALGVAEPLPDDIAKTLRPFTFGNPLRRVMSRARTTAIYLRRIAGIDAMMRRFLDEFYRVYDDFESHDDSADSGAQAYARYRELDRELVHRWGPMMVLDAMLLTLTGLLYVLTRIFLPKAPEWFLYAVAGPGADVESAEPARAMSALAAIVRENEDLRKLLESTAPEGVYDALVTAGHDEFRARVDEYIDRYGYRSLDELKLETPDLREDPSGLFVMVLAALPEQQDRAADDAQRYLDTHLRGWRRAIYERLRRKVSRCAGHRESLRFCRTRAFGMVKRTIRIMGRDLVRRNIIDEFSDVFHLTLPQLRGCYEGGETAGLRAVVAARRQQRAADARLVAPARFVTHGGGFGPAELAAAGWVPITDTPAATAGSVFTGTPSGGGIGAGPAVVVDEPRDVAGGVLVTYRTDPGWVAVLPSATALVVERGSPLTHVAIVARELGVPTVVQIPGVTRSVRTGMPLRVDGSSGTVTVLEEGEAADAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEP1</accession>
    <name>A0A231HEP1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator KipR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kipR_3</name>
        <name evidence="5" type="ORF">B7C42_00576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030512998.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47451">
        <property type="protein sequence ID" value="OXR47451"/>
        <property type="gene ID" value="B7C42_00576"/>
    </dbReference>
    <dbReference type="GeneID" id="66720722"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="24466" checksum="136F5C4E78CEEA40" modified="2017-10-25" version="1">MRQHSGIGVLDKAMAVLYAVAEQPCGLNELCTRTGLPRATAHRLAVGLETHRMLARDAAGSWRPGPALSELATTAEDPLLDAAAVILPRLREITGESVQLYRLDGHSRICVAALEPTSGLRDTVPVGARLPLTAGSAAKVLLAWADPELQRGVLADAVFGERALAEVRRRGWAQSAAERSAGVASVSAPVRDGSSQVIAAVSVSGPIDRMGRRPGARWAADLVAAADALHKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFB3</accession>
    <name>A0A231HFB3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47416">
        <property type="protein sequence ID" value="OXR47416"/>
        <property type="gene ID" value="B7C42_00539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010846">
        <property type="entry name" value="DUF1460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07313">
        <property type="entry name" value="DUF1460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234772" evidence="1">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28541" checksum="12C0D7298455A466" modified="2017-10-25" version="1">MRSTRILPVLLVLVAAVLLLPTRASADAAIDDTTSHRIDELVALRAGATGANKGELLDLLSKQFLGTPYAANTLIGSATQPEQLVADFRQVDCFTFLDYVEALSRTTDRNRFEANLIDTRYAAAQVDYTHRKHFFTDWAHVADVAATDITGSLSPAAVTVSKHLNAKGDGSVYLPGIPVVDRDITYIPSASVDQGVINGLRTGDYIGAYADQPGLDVTHVGILISTPSGPVFRNASSLAANNKVVDTPLAEYLQSVPGIVVLRPRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFJ4</accession>
    <name>A0A231HFJ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47652">
        <property type="protein sequence ID" value="OXR47652"/>
        <property type="gene ID" value="B7C42_00777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="13026" checksum="A89C876B539A07AE" modified="2017-10-25" version="1">MDKSEPSADELVESVIRAGAEAGYRVDRDEAGRLRITAVREVPVDPALVFRVTDGELRDYYTRLSAESGGPLGAGTPWEAWMLLMSTHLDEAVYEAGRLDGPGAIVIGDTGFRAVSRSATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFM8</accession>
    <name>A0A231HFM8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_00875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47750">
        <property type="protein sequence ID" value="OXR47750"/>
        <property type="gene ID" value="B7C42_00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="80" mass="8487" checksum="FAF99DE440BAA1BB" modified="2017-10-25" version="1">MNVLIILALVLVAVAATVVVWTENPQRQAVTLGVYGALLSPLFLVLGAPDVALSQIAVGTAVVPLMVLLAVRSVRRRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFS3</accession>
    <name>A0A231HFS3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleamate amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nicF</name>
        <name evidence="2" type="ORF">B7C42_00946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.107" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47821">
        <property type="protein sequence ID" value="OXR47821"/>
        <property type="gene ID" value="B7C42_00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="23110" checksum="BE4A9CFBEAEF035A" modified="2017-10-25" version="1">MSRADAVTVEEQVRARYRKGGLLGTLTPGTHPALVVVDLQYGFTEARYGPGFDMDAVVAATRDLVDAAHEHDVPVYFTTIAFPADGDGTAGTWLRKMPAMRGLRNGDRSVRIDHRLGRRGDDPLVVKQAASAFSGTDLARRMAAAGIDTVLVTGATTSGCVRATVVDACAADLPAFVVRECVGDREEAPHRAALLDIDAKYGDVIPLATAHAIVKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG28</accession>
    <name>A0A231HG28_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47799">
        <property type="protein sequence ID" value="OXR47799"/>
        <property type="gene ID" value="B7C42_00924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="56" mass="6501" checksum="E07014294CD39E1F" modified="2017-10-25" version="1">MMGRQAAAVVYMLALVAFVVSVDVLFFRHYFRERLLVNVGIVLVFAAFYLRFVQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG31</accession>
    <name>A0A231HG31_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme chloroperoxidase</fullName>
            <ecNumber evidence="2">1.11.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cpo_2</name>
        <name evidence="2" type="ORF">B7C42_00913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.10" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47788">
        <property type="protein sequence ID" value="OXR47788"/>
        <property type="gene ID" value="B7C42_00913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016691">
        <property type="term" value="F:chloride peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="30857" checksum="E7F0F6C6E31D167B" modified="2017-10-25" version="1">MRDVPGERMRVRGIELYVEQRGAGQTCVLFESGAGAGRTLWDPVVSLLGDTVRTATYDRAGRGRSARVRPPQDIDEMAATLVALAEMLAPRRLILVGHSMGGLIVRRAAESIVPQPIGLVLVDPTPEAAPFYADWAATAARTDRILAVQQSLARCRPVIRALTGSYGRMFPADTYETMLREDFTPAGIASTRSEFDAFATGIGPFRDNPPQPPGGEVVVISALRADRLHARRHDTVREYQRRFADRVNGRFEDADSEHIVPAECPDQVAAAVLRMAGAPERAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSV9</accession>
    <name>A0A231GSV9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000081">
        <property type="protein sequence ID" value="OXR39710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780507.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000081.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39710">
        <property type="protein sequence ID" value="OXR39710"/>
        <property type="gene ID" value="B7C42_08212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="11785" checksum="21C119C0887B21F7" modified="2017-10-25" version="1">MSTDRDRVTEVMSRIERAKARILSTGELSERVGGGRAPARSTTFKRASAELHRAEQARNRLLLEMAGNADAVSGALAERLGLTGRHAASLLRISRTGSDQMRTYAFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSW4</accession>
    <name>A0A231GSW4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PPE family protein PPE29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_08221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000082">
        <property type="protein sequence ID" value="OXR39707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39707">
        <property type="protein sequence ID" value="OXR39707"/>
        <property type="gene ID" value="B7C42_08221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="3">
        <location>
            <begin position="46"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="501" mass="50450" checksum="ED7080A91BC7AF36" modified="2017-10-25" version="1">MDAVTGAAAGLGQVAGDVKASAEAAASLAGMAGAAVSFIEGFDFAALPPEVNSARLFAGPGPEPMEATSIAYEAVSEALMAAATGFEGSNGVMQVAWEGEAGTKAHTAFSRHTEWYRQQAVVAKQTSMIVGAAAAANHGARLAMPPLPMILANRAMSVALAATSSATMGATEPLIAANEMAYLFMWERASETMYTYQGISSGLIGALPPPTVAPTIAGDGGEFGGPSGTTYFDPPHTPGGGPTGHTGPTGPGGGPSGPGDGPGSGPGDGSGDMGGGHDPTSPGGGSTDPADTGVDPTQTPPGGTEAENAVSDVNDAMSSMTDSLGNSGGDGNYLTQEQHGFYGTSPYSTTLMGLNGGVGSAVTFSMARSGLGAVPASGAGFRMPANWNPMGARAFGALPTEPPTGPVPPRNVPRGAVAPKARMRRRRDDEKKPSKVFVPGEHDEVPVLEQAPVVGVIEYADDDHTIDAVPELVPAFGVLERVEDEPVPVSMDVPGEYRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSY5</accession>
    <name>A0A231GSY5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000085">
        <property type="protein sequence ID" value="OXR39692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781996.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000085.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39692">
        <property type="protein sequence ID" value="OXR39692"/>
        <property type="gene ID" value="B7C42_08238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="8147" checksum="907BFF31366EF9EB" modified="2017-10-25" version="1">MAIKYLSRAGVAERIGVKYDTLNRYKLPPADAEIGDRKGWLPQTIDEWNERRPGRGQVKNKRWNLPPDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT08</accession>
    <name>A0A231GT08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000149">
        <property type="protein sequence ID" value="OXR39611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39611">
        <property type="protein sequence ID" value="OXR39611"/>
        <property type="gene ID" value="B7C42_08321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="5193" checksum="1E43211B809DC12F" modified="2017-10-25" version="1">MIAGCAEYMRAWNTSPMMTADRMIALCPLSIIGKAKKPQVPAVTAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT11</accession>
    <name>A0A231GT11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000086">
        <property type="protein sequence ID" value="OXR39685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39685">
        <property type="protein sequence ID" value="OXR39685"/>
        <property type="gene ID" value="B7C42_08243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="5254" checksum="83684AC23D4FD748" modified="2017-10-25" version="1">MDQQGLAAAIGRSTSYVSTRMRGELPFDLNDVENIAIVLEIPYSQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT87</accession>
    <name>A0A231GT87_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000085">
        <property type="protein sequence ID" value="OXR39691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781995.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000085.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39691">
        <property type="protein sequence ID" value="OXR39691"/>
        <property type="gene ID" value="B7C42_08237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="71" mass="8094" checksum="A3F9B4A55EA416FB" modified="2017-10-25" version="1">MRQLPDMHAVLDFVEVLWTESMDAKELEEWHREMYREETIDMESGELKAVPAGFDAADELAGFDAFAAMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT92</accession>
    <name>A0A231GT92_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000058">
        <property type="protein sequence ID" value="OXR39839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39839">
        <property type="protein sequence ID" value="OXR39839"/>
        <property type="gene ID" value="B7C42_08080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="64" mass="7081" checksum="A9EBF5C5956ED152" modified="2017-10-25" version="1">MGYTRHIHIESGALTLDYRASAEQAQNVAAELMRGVYSEFGLRIIVDDNVTDELPSLPCGGLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTJ0</accession>
    <name>A0A231GTJ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000055">
        <property type="protein sequence ID" value="OXR39865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39865">
        <property type="protein sequence ID" value="OXR39865"/>
        <property type="gene ID" value="B7C42_08062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="15963" checksum="F8A0DE0055B63404" modified="2017-10-25" version="1">MNAETLPRAMGYVCVDLVTAIEPLLFQSQRIAARLGYDYIGMTRGSSLIVPEALIDHVATHEIELLIVPHIAHLRGRIPAELGEMTDIHDLATGRTYERGGGYAPEGGRRNPLDTSIPIERTGDKRTGLETINFQQPQSPGAHTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTK7</accession>
    <name>A0A231GTK7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39954">
        <property type="protein sequence ID" value="OXR39954"/>
        <property type="gene ID" value="B7C42_07961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="16416" checksum="5942C4039776457E" modified="2017-10-25" version="1">MNNLGNLLYVRRRLHEAHEQYRKAAERGNPEAMGNLAGLLHKVRHDREAERWWRAAAAAGSGDAVFNLAVFLDKTQRFDEAMNWYRQAAEMGQRDAMHNLAIRLRHRGSSDEAADWWQRAGHKKAQGPHERLRDPVSRVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUC7</accession>
    <name>A0A231GUC7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_29</name>
        <name evidence="9" type="ORF">B7C42_07760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40178">
        <property type="protein sequence ID" value="OXR40178"/>
        <property type="gene ID" value="B7C42_07760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="384" mass="42105" checksum="7A552A652A70FCCB" modified="2017-10-25" version="1">MERGHYNDDHRAFAVLARDFVRTEVAPHYLEWEAEGIVPRSVFARAGQLGLLGFAVPPDYGGLGAKDFRYNQILIEEFMAADCGGVGLNFALHNDICTPYLVDLSTEEQRQRWLPGFVAGNLIAAVAMTEPGAGSDVAGIRTSAVDGGDHFVVNGAKTFITNGINADLVIAAVRTSPERHRGITLMVIEQGLAGFGRGRNLDKLGLRSQDTAELSFEDVRVPKANVLGEVGRGFEYLMRNLAQERMQISVACLARARAALQTTVEYVRERKAFGQPIGAFQNTKFTLADVATEVSVAEAFIDTYVRELNAGRLTPADAAKAKLWASEMEFRCIDKCQQLFGGYGYMREYPIARAAADARITRVYGGTSEIMREIIGRDLRLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVV0</accession>
    <name>A0A231GVV0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40750">
        <property type="protein sequence ID" value="OXR40750"/>
        <property type="gene ID" value="B7C42_07174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="98" mass="11108" checksum="F40918F8AF01A35C" modified="2017-10-25" version="1">MQPGNYRVDLVGMQNLIDKAVDFEKRLEDRLSDIRKQVTNLHIDWTGQAAQTHQQASAEWVTGATEMHTALGELRKALDHARSAYHNAGETNHGMWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW24</accession>
    <name>A0A231GW24_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH oxidase</fullName>
            <ecNumber evidence="4">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40772">
        <property type="protein sequence ID" value="OXR40772"/>
        <property type="gene ID" value="B7C42_07196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="10"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="491"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="704" mass="74328" checksum="1D2527D13BE48E61" modified="2017-10-25" version="1">MPRNQTFPHLLAPGTIGPMTVPNRVVLPAMDMNLCEDGEIEQGDIDHFVARAAGGTGLIITGCCAVAYPVGCASTKEPGLSEDRFIPGLRALADAVHAAGSTLCVQMTHHGKIARIDTVQGRPLLVPSAPRGSADMSALADNTPEELQKLAAVTGGKQATYREATQDDIDWVVRCFAEAAGRVKAAGGDAVEIHCAHGYILGGFLSRADNKRTDDYGGSLVNRARLAVEVIRAVKAEVGDALAILVRIAGREFGEDDALTTEEAKQASALFEAAGADAIHVTGWGRNPFSNFTDGPLPDRVGAYTELAGEVKKAVSIPVITVGRVLPEIGEKVIAEGKADFAAMGRQLLADPELVNKLRAGTPQNVRPCINCYVCVQENFWDDTPLCAVNPALGDENVLPLVRATTSKRIVVVGAGPGGLEVARLAAERGHRVTVLDKADRLGGTLWFSSLTTPDNERLLNWLKGRVEQLDIDIRLQTEATVPLIQALNPDVVVVATGAVRDRPAVPGSELPHVHTGDTLRALMTGVGDVSRVPPLLRTVAKLGKVSGITKSPAAIRSVTRRFLPMGKNVVVIGGSLVGLELSEFLAERGRAVTLLEEGQQLGVPMAMPRRWTAVRHAGEAGVTIHRHATVQRITERHVEFRVGDRTSTAAADMVVVASGVSAQAPLADALAGLVPEVHVVGDAGSVDYIEGAIHSAWKVAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWA9</accession>
    <name>A0A231GWA9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_6</name>
        <name evidence="6" type="ORF">B7C42_07048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40913">
        <property type="protein sequence ID" value="OXR40913"/>
        <property type="gene ID" value="B7C42_07048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="284"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="317"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="538" mass="57446" checksum="0694576F8BFEC07A" modified="2017-10-25" version="1">MSTTGPLLRIDDLTVRYRDAAAPAVSGVSLEVAAGEFVSIVGESGSGKSTTIHAALRLLPPAAQVRAGALEIGGQDVSRWSDRRLARVRGPVVGFVPQDPGTSLNPVKPVGRQVLEALRLHRRADAGRDLVVEKLAAAGLAAPERVYRQYPHELSGGMKQRVLIAIALANDPVLLVADEPTSALDVTVQKRILDRLQVLREELGLGVLLVTHDLGVAAERSDRLLVMQRGRIVEQGAAAAVLSAPRHEYTRRLLAAAPAAHSGRLAPSAGAPVRSEVVSAPPVLRLSEVTKGFGGGVRAVDEVSLSVRAGTTHAIVGESGAGKSTLARLVVGLERPDAGAVWLDDVRVDGKGRRPRPLRRQIQLVYQNPYTSLDPRFDIASIIGEPLQAFGLIRDRAARRRRVAELLDAVALDRAHLSRRPAELSGGQRQRVAIARALAAEPRVLVLDEAVSALDVSVQAQILQLLTDLQAEHGLTYLFITHDLGVVRLIADDVTVMRSGRVVETGSVTAVFEEPEEEYTRTLLAAVPGARAQLPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWC9</accession>
    <name>A0A231GWC9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40872">
        <property type="protein sequence ID" value="OXR40872"/>
        <property type="gene ID" value="B7C42_07007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010581">
        <property type="entry name" value="DUF1152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06626">
        <property type="entry name" value="DUF1152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="24961" checksum="56B5149DEFB48AA9" modified="2017-10-25" version="1">MWLRDHGYPDRVFAIRKGGPADIRAAYAWLARELSLDAIVLVDGGTDLLMTGDEAGLGTPVEDVTSLLAAHTLDLPVKLAVCVGFGVDTYHGVCHAHFLENVAALSKSGAYHGVFALLPGIAATDAWLDAVDWVQRRTPGRESIVCASITDAARGEYGDHHSLTRTRAKGAELFINPLMSMVWGFDLDAVADRVLYRHDIAHATTPFEVAAAIEAFRDHIPLRPRRTIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWR9</accession>
    <name>A0A231GWR9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor Bm3R1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bm3R1_3</name>
        <name evidence="5" type="ORF">B7C42_06834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41064">
        <property type="protein sequence ID" value="OXR41064"/>
        <property type="gene ID" value="B7C42_06834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22830" checksum="1A4CE3118668523C" modified="2017-10-25" version="1">MPDDLPHPLRSDARDNRERILEVARALFATEGLDVPMREVARRAGVGPATLYRRFPTKQILATEAFAEQMHACRAVVDEGLAEPDAWRGFCLVIEKLFALHARSRGFTEAFTATFPHALDFTTDREYALKAVAALAHRAKDAGRLRPDFVVDDLILMLLANRGMHIGSPATRVAASRRFAAFVIRAFATTTDTTPLPPVARVAPAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWU6</accession>
    <name>A0A231GWU6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776924.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41079">
        <property type="protein sequence ID" value="OXR41079"/>
        <property type="gene ID" value="B7C42_06849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="31762" checksum="45243F8196537AA3" modified="2017-10-25" version="1">MTTEAKAALRSVTATTPLAEILDIVAEDGGVIIENFLSADQIARFNAEVEQPMAALAPGSTHENEIVAEFHGANTKRLTNLVTHSKTFREEVLEQDLIHELCDAVFLEESGTYWLTTAQLIEIGPGNRAQFLHRDLENWYPFIGMGPQGPEVCVNFMIAFTDFTEENGATRVIPGSHLWDDFQNRGTPEDTIPATMKAGDVFFYSGKTVHGGGANLTTDQFRRGLAFALNPGFLTGEEAYPFLVDRDIAKQLSPRVQRLLGFRSQYPTGSPGLWQVDYSELGDYLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWV0</accession>
    <name>A0A231GWV0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigH</name>
        <name evidence="9" type="ORF">B7C42_06832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41062">
        <property type="protein sequence ID" value="OXR41062"/>
        <property type="gene ID" value="B7C42_06832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="124"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="34093" checksum="C29F98CFF2C818B0" modified="2017-10-25" version="1">MTVLVDERPVTTGDSLSYPLIDIIVPDTGFDRRPSRAVDSDATATEGTSVTSDDELAADRPRGDTAGGSRPEDIEIPDDPVDDDPASEDAEAREDAEIDGDSTVRSTADEAELARRFERDALPLLDQLYGAALRMTRNPADAEDLVQETFAKAYQGFRSFREGTNLRAWLYRILTNTYINSYRKKQRQPAQYPTDEITDWQLAATAEHTSTGLRSAEMEALEALPDDDIKAALQSLPEEFRMAVYYADVEGFPYKEIADIMGTPIGTVMSRLHRGRKQLKGLLADVAHERGFDRNRTGNGARQEVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX27</accession>
    <name>A0A231GX27_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41180">
        <property type="protein sequence ID" value="OXR41180"/>
        <property type="gene ID" value="B7C42_06776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012782391" description="SLT domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="213"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="31397" checksum="BCF2AF724A7EE927" modified="2017-10-25" version="1">MLAGAAGPLAMAAMSTLNSMAGHFGEGVPSAETGRSAAPPTLADTGAPTGPIAWDSGAGAQYSAVRQSNTAESGALGEVNTELRRILGSTVEDTMAGRAAMAAIIAETDAALTALGKVGTGAAAQSQVVAALDAALQRAGSVLRGGQAQSAVSAEQINALAARYIRDSGGGRPARVYRAAGASGGPPGTRPAGAVGQWIDQAMQILRQNGYDTSRIDPADIATIIAHESAGNPHAINNWDSNAAAGTPSKGLMQTIDPTFDAYALPGHRDIWNPVDNIIAGVRYAIHRYGSVDRVPGIVGMHRGTGYVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX42</accession>
    <name>A0A231GX42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">guaD_3</name>
        <name evidence="4" type="ORF">B7C42_06738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41142">
        <property type="protein sequence ID" value="OXR41142"/>
        <property type="gene ID" value="B7C42_06738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="15641" checksum="D836189B2AF1851B" modified="2017-10-25" version="1">MQHDNDHLRRAIALGEEAGRRGNRPFGAVIVAADGTTVAEGRNEVAASGVVTAHAELGALTAAGPSADLVGATVYAGGEPCPMCSAALVWAGVARIIFAAAEADFAAIIGGHPRFALGCAEVVGASDAEIAVSGPHLGEEALVPFRRYAETAGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXE0</accession>
    <name>A0A231GXE0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="4">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acsA_6</name>
        <name evidence="4" type="ORF">B7C42_06701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41303">
        <property type="protein sequence ID" value="OXR41303"/>
        <property type="gene ID" value="B7C42_06701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="94"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="533"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="650" mass="69616" checksum="43F38F075CCBCFF7" modified="2017-10-25" version="1">MSTYVWNPTPDYLEHANVLRLARAHGIDSIDELRRRSTADVSWYWDAAVTDLGIPFATPYDSVLDLSNGIEFPDWFVGGTFNAVDACITRWLGDNADRAAIVHEAEDRSVHTITYGELAEQVGRVATGLTELGVGEGDAVAIYLPMIPEAVVACYAAAGIGAIIVPLFSGFAAPAIASRLNDAQVKAVFVAEGTVRRGRKVGMADELAKALAQTPSVRSVITVENIGGTVDFAGRDVATTAWSSLVGPEVAPYEFRPFPATQTLMLGYTSGTTGKPKGAVHTHAGFTIKVATEVAYSFDTNAGDTFCWITDMGWVMGPLAAFGTHANGATLLLYEGSPDVPDTCRLWDLVQRHRITMLGVSPTLIRALKSTPPAEIATRDLSSVHVLGSTGEPWDPDSYDWLAETVFGGRVPVINFSGGTEVGGSFLAPYPVEPIPSCSLGGPSLGMDVDVVDDTGKSLRGSIGELVCRQPWPAMTCGVWHDRERYLESYWSTFPGIWCHGDYARVDDDGQWYILGRSDDVMNVAGKRLAPAEVESVLTTHPAVAEAAAVGIPDPKKGECVWAFWVPRQGADTEGVSDELRTLVAEGVGKPFAPAKVWAVEALPKTRSAKILRRAVRAAAIGTDPGDLSSAENPEAVTAIRDVVHRTRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXG1</accession>
    <name>A0A231GXG1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41191">
        <property type="protein sequence ID" value="OXR41191"/>
        <property type="gene ID" value="B7C42_06787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="493" mass="47909" checksum="360074686025C00A" modified="2017-10-25" version="1">MPENTAGTETIGLPKLLQDGVTPTTGLPVAGSDGVTGSGPLGANPLAGPQFPAGGPQTDMRVINAPQTPGAGPPGTPGSAGPPPGGPHEPGGPTKPGPGKPGPTKPDPTKPDPTKPDPTKPDPTKPAPTKPAPTKPAPTTPPPANPEKHYWTVELDAPPGAKPAVKAIVALARTAIQTAVDLLGRGMPKPPPEVASLLKPVVFTNLGKSDTTVGYRQAMAAVNAKQTSLLEYDQEIARTSVLVAASKDETLASIKNIVAELQAVVKAVPAKATTAQQAALMQQISAAVAQVYRLVDAVYADNQSRAGTSSGSGSGSGTGTSSSSGAASGGTSASGGGGGLGDILGQLLPMAAMILPMGAMVAAPLVTQAMQKNQKDKEAELHSNGEVTPGTGAAPAAADPNAAVPNGAGPAAAPAAVAPNGAPTALAPGAAAPGTAAPTQLAGATGQTPGTPPPITAPATGASAKDRTKPPTAAAGPNAATPQEPENASEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYG8</accession>
    <name>A0A231GYG8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DegU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degU_4</name>
        <name evidence="5" type="ORF">B7C42_06280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036501594.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41639">
        <property type="protein sequence ID" value="OXR41639"/>
        <property type="gene ID" value="B7C42_06280"/>
    </dbReference>
    <dbReference type="GeneID" id="66719722"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="23019" checksum="DB8994DCBCFD4E43" modified="2017-10-25" version="1">MPITVLVVDDQELMRAGLKMVLGAHPDVDVVAEADNGATAVRLAGELAPDVVLMDVRMPVVDGVAATAQILESGCGSRVLVMTTFDLDEHALGALRAGASGFLLKDTPPEDLISAIRSVAAGDAVVSPKVTKRLLNRLIAADPARVRDPSVLDVLTAREREVLEQIAAGRSNAEIAAELYLSEATVKTHVGRVLTKLGLRDRVQAVVLAYETGLVTPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYU6</accession>
    <name>A0A231GYU6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmE2</name>
        <name evidence="5" type="ORF">B7C42_06094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780830.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41752">
        <property type="protein sequence ID" value="OXR41752"/>
        <property type="gene ID" value="B7C42_06094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="92" mass="10449" checksum="E4A8D57F9033D3D2" modified="2017-10-25" version="1">MKSGIHPEYHPVVFEDVSTGKRFLTRSTATSTRTVEWSDGNSYPLITVDVTADSHPFWTGAHRVLDTQGRVEKFERKYGRRTPRPGSVRGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYX6</accession>
    <name>A0A231GYX6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative L-galactonate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lgoT</name>
        <name evidence="7" type="ORF">B7C42_06158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41816">
        <property type="protein sequence ID" value="OXR41816"/>
        <property type="gene ID" value="B7C42_06158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="31"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="438" mass="45098" checksum="05F6942619DA8059" modified="2017-10-25" version="1">MQLNTTPARPAAGDSVVSTGLPGRARRYPWLVFALAFGLLLADYMSRQVLSAVFPLLKTDWGLTDSQLGSLNSVVALMVGLLTFPLSLLADRWGRVKSLVLMATLWSIATLLCALASNYHQMLGARFLVGVGEAAYGSVGIAVVLGVFAPRVHASLSGAFMAGGSFGSVLGVAAGGAIAVHLGWRWSFVAMAVAGLLLAALFAALVDERKLARHADPDSAEPVKHNGFRAPVSSLFTNPAVLCAYVGGGVQLFAAAVLLAWTPSFFNRVYGLAADTAAVAAAGVVLLVGAGMVCCGIVTDRIGRHDLSRKWLAAIAFCSISLVCLTLGFSIEHGAAQLVLIGVGAWFSGGSSGPTAAMVANLTHSSVRASAMGTLTLSNSLLGMALGPFVVGVLADHYGLTAALRLAPLAYLVAIAALVAGRCLYPAGLRSLAAVHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ26</accession>
    <name>A0A231GZ26_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41825">
        <property type="protein sequence ID" value="OXR41825"/>
        <property type="gene ID" value="B7C42_06167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="3">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="3">
        <location>
            <begin position="132"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="231" mass="25039" checksum="9551BA6061F85E9C" modified="2017-10-25" version="1">MCVPLGLNRDMRSDYHANLRQLAELLHAMCEQDRTAISAATYAVVNADIEQAEAALDVVGQVEEMAQRAEQEALRLLALQAPVASELRRVVTAIQLTGHLHRMGALAGHIATSARRRHPEHVVPEPVRPLVERLGSTACAIATSAAAVLETGDPYDAAGLDAQDDALDQLHEQLLAAVLDHEWAHGITAAVDLTLLGRYYERFADNAVEVGRRTIFLTTGETADNWAPDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ45</accession>
    <name>A0A231GZ45_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41884">
        <property type="protein sequence ID" value="OXR41884"/>
        <property type="gene ID" value="B7C42_05868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="38440" checksum="6B2A560D0558D3DC" modified="2017-10-25" version="1">MKMSRKYLIGTGAVVSLALIGGVGFTVVEPTGPQPQSGFCAQMPDAIGLYPGNPITQMGLQVGRVERIRPAGDHVEVTFSLDGGRRFPADVRAVTRSKSILADRSVELVGNYRSGPELTAGHCIPEDHSFTPKSISEIAGSAADFIDALSPNNSKDSFEKAVAGFEQALRGQGDNARSMMLHASAAAASPDRLTADIGAIIQNMAPLTDEALQRWPAIRSILDQMPEVVNAGIDLWPGVVDVCVGVGWLVNLLHDIQTNYGGDLWPLLQGPVADVIHLAASRSKDIASLLDSIPPVASMLRQQAANDGGMSIDYRPPTVQLDSPAAPELCAAANQVAPGSCSADQGHVQVPIADLLDMVLAKGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ61</accession>
    <name>A0A231GZ61_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetracycline repressor protein class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tetR_13</name>
        <name evidence="9" type="ORF">B7C42_05890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41906">
        <property type="protein sequence ID" value="OXR41906"/>
        <property type="gene ID" value="B7C42_05890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="23968" checksum="183C16E06B23C884" modified="2017-10-25" version="1">MPRPSQPLISRSAVIAASIEIIDSEGLDAFSLPKLAKYIGVSAPSLYHHFADRSAILSAVARHIAGAGPIPRRKPGPDWPEFFVQLALNFRRSILRHPNAAPILLQYLPRDLLIGTYEETARFLEASGVPTHLHVQILDGMERLTLGAALTDAVRGASTRTTIFPNVDPESQPVLARALAQNTLTSKGLYEEMVRSFLYGVMRNENGAVTKDSQTSSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZD9</accession>
    <name>A0A231GZD9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator AcuR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acuR</name>
        <name evidence="6" type="ORF">B7C42_05958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41974">
        <property type="protein sequence ID" value="OXR41974"/>
        <property type="gene ID" value="B7C42_05958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="22506" checksum="F710EC8F7991DAEE" modified="2017-10-25" version="1">MVEDVATTTEPAERQQSTRRGKPAPAQRLLDTATDLFSRYGIRAVGIDRVLAEAGVARASLYQSYGSKDALVQAYLEHLDRRDRSRWDEAVAAVREPVDKVLTFFDLALASAPTKGFRGCQYANAATEFPDQALEPVVAHRRWMFDTLTTLLRECGSADPEELAVRLQLVYDGALSGSKFAHSLEPLRTGRSLAAQLIAQSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZP8</accession>
    <name>A0A231GZP8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42022">
        <property type="protein sequence ID" value="OXR42022"/>
        <property type="gene ID" value="B7C42_06006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="21076" checksum="459EAEC7CCD6AD63" modified="2017-10-25" version="1">MAVTIEAAVEQVWPWLVQMGWDRGGFYSWDLFDNAGRPSAREVHPEWQDLGVGDRLKCLGLPSYAVVTLEPNRFLGLYWLADLRGQLLDPSRPRPSAYMEGLWGFRLTELPGRRTRLVIGGYQAARPRWFERLMYDWVFPLVVWTMQARMLAVLKRNVERTASALAEPQPRPADGGMSGDVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZR0</accession>
    <name>A0A231GZR0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 144</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782814.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42096">
        <property type="protein sequence ID" value="OXR42096"/>
        <property type="gene ID" value="B7C42_05695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="401" mass="42210" checksum="F89FDFF959749167" modified="2017-10-25" version="1">MTVPDLFSTEALQDPYPLLEQLRDAGDVHYLPDQQVYVVLGFEAIRTVLADPQTYSSNLVAVLSAASGSATVSVAEAGAGVDVLATADPPAHTAQRALVMSRFSPRAVAETTELIDAAVAPAVAGLVASGGGDWMTTVAHRVPVQVIGELIGLPRADHQRLAAWSDAAIDLVSGVASPERAGQAALAVLEFAQYLGERLDRADPGQDTGVLSSVAAAVASGTLTRDQGAMLLVQLVTAGAESTASLLGTAVRLLAGDQQLQAAVRAEPDRIGALVEEAVRIESPFRGHFRVTTARTRLAGVRLEPGARLMLMWGASNRDPRIFDHPDRVDLDRGQPKLHHSFGRGIHFCLGAHLARKETTQAVRALLEATATVSLSGPEPAYVPSLIVRRLAHLNLSLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZV1</accession>
    <name>A0A231GZV1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42120">
        <property type="protein sequence ID" value="OXR42120"/>
        <property type="gene ID" value="B7C42_05719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="18725" checksum="535947868F4EB0F3" modified="2017-10-25" version="1">MTDTLTDIPTAPLRLARPVPVARATSARPVPVTGAASEWQEAKTVLVTRVAGPQQLVTVPRLVVPIGLGQLAFRVSSQSPEADDLMRDGRVLVQAGDRRGHPALGSHQRQGHAQLVTAGTLVSFVHAEIEAKYRWQIPLAKFGHRLARGNAPYGDVVVLVTVQESPSRMLPPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H012</accession>
    <name>A0A231H012_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bphD_2</name>
        <name evidence="2" type="ORF">B7C42_05793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778514.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42194">
        <property type="protein sequence ID" value="OXR42194"/>
        <property type="gene ID" value="B7C42_05793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018774">
        <property type="term" value="F:2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="30549" checksum="679E8A617205A9D3" modified="2017-10-25" version="1">MTITQDSAARTVTTPDWKLRYYEAGPVDAAPIVLLHGSGPGATGWSNFSGNIPALAERFHVYAVDMPGWGESDAATVDRLDHVDAAVQFLDAVGVERAAFVGNSMGGHTSLRLAIHHPERVTHLITMGPPIGKGPTLFGAGDGPSEGLKVLISAYRDPSPENMRRLVEVMTFDKARFATPELVQARSDAALARPEHLHNYVAGLAAGTPIPEWVDRSRLADISAPTLLIHGKDDRVVSYENTLLLLAHIPDSRAVLLNRCGHWAMIEHADEFNRLVTGFVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H098</accession>
    <name>A0A231H098_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42171">
        <property type="protein sequence ID" value="OXR42171"/>
        <property type="gene ID" value="B7C42_05770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045991">
        <property type="entry name" value="DUF5947"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19372">
        <property type="entry name" value="DUF5947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="213" mass="23576" checksum="AE82CC622BBD0825" modified="2017-10-25" version="1">MNPTVRALRRLAAERPAAPAGERCEMCAEDIGATHQHVVDTASRHMLCVCRGCYLLFTDQAAALRYRAVPQRYVSFPDFRMSLPEWDGLEIPVGLAFFFHSSSAGRTVAFYPGPAGATESELPLNNWRAFTESHPEFGDLADDVEALLIQVPERDAAAARCLLLPIDACYEFVGRIRLLWRGFDGGGDVRDYVARFFAETTARARAYDAGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0I7</accession>
    <name>A0A231H0I7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A-factor receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arpA_2</name>
        <name evidence="5" type="ORF">B7C42_05594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505157.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42394">
        <property type="protein sequence ID" value="OXR42394"/>
        <property type="gene ID" value="B7C42_05594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="23753" checksum="51DA3C80D96B2C3A" modified="2017-10-25" version="1">MARQARAEITRDSVLAGAADVFLRLGYANASLSEIISQSNVTKGALYFHFGSKEELARAVVDQGNERLRGACQGFFDPRVPALEAAIGITYVVADLTMNDPMVGAMLKLTHQIGDYRGASGENITKTWGETQILLAERAIAQGDLKPDLDPETIGLLLQEMTSGVHITAVGTESIDQMAVRMERMWYFLLPSIVPDEKVAYFREFAARRLRRYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H238</accession>
    <name>A0A231H238_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42911">
        <property type="protein sequence ID" value="OXR42911"/>
        <property type="gene ID" value="B7C42_04797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="26479" checksum="56DA229B61C509D3" modified="2017-10-25" version="1">MGVREVDDGVIVLFGGRSEMGLEVVRRICADREIVLAARRSDRLGEETAMLRAAGARAVHAVEFDADDLSGHQPLLEKLAADHGRIGVAILAFGILGDQARAEQDPAAAVAVLHTDFVAQVSLLTVLANLLRAQGSGQLVVFSSIAGARVRRANYVYGSSKAGLDGFASGLSDALHGSGVHVLLVRPGFVIGRMTQGMSPAPLSSTPDQVAEAAVAALRRRATSVWVPRALGPAAAVARWVPRAVWRRMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H243</accession>
    <name>A0A231H243_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4333 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42915">
        <property type="protein sequence ID" value="OXR42915"/>
        <property type="gene ID" value="B7C42_04801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025637">
        <property type="entry name" value="DUF4333"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14230">
        <property type="entry name" value="DUF4333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4333" evidence="3">
        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="26467" checksum="2752108A3042B09F" modified="2017-10-25" version="1">MSGPYGPNETPGPGEGHSSDPTQQWSGQPQPGQSGPAPQWGGQQPQQPQWGQPAPSQQQWQPQQQPQQPQWGGQSQPSWPQQPPAQAQPWEPTQQQWGQPPQPSQQQWAQQQPTQQGWAPQPDQSQQQWGMQEPQLSTTPAKKSKKGLLFGGIGVLVVVVVAVVLAFVFLGSDKLDNKAVQDGVQKVLKDSYGIDDVQSVSCPSGQKVEVGGTFDCTLKVGGEQKKVTVKITKDDGTYEVGRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H254</accession>
    <name>A0A231H254_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biphenyl-2,3-diol 1,2-dioxygenase</fullName>
            <ecNumber evidence="3">1.13.11.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bphC_1</name>
        <name evidence="3" type="ORF">B7C42_04793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.39" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778342.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42907">
        <property type="protein sequence ID" value="OXR42907"/>
        <property type="gene ID" value="B7C42_04793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018583">
        <property type="term" value="F:biphenyl-2,3-diol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="142"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="31585" checksum="2433C495EC1DB3C8" modified="2017-10-25" version="1">MNIEQLGYLGLSARHPEAFVTYATDILGMQRVAGEDGTTHFRIDDRHHRVTVETGERDGGAYYGWELADGAALAAAVDELSDRGVAVSVATARELEIRRVADMVHFLDPAGNRVELYHGAAAGEGQFTSARDVEQFVTGDLGLGHVVLASPDVAALQDFYTDILGFKISDTMRTPFRASFLHTNPRHHSIAFVDGPFFGIDEPFLHHFMLEVPDMDQVGRTYDLVLDRDVPVTMSLGRHTNDKVFSFYAQSPVGVNTEFGFGGVLIDDETWEPTEIPGPDLWGHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H284</accession>
    <name>A0A231H284_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">B7C42_04823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778377.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42937">
        <property type="protein sequence ID" value="OXR42937"/>
        <property type="gene ID" value="B7C42_04823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="25901" checksum="2050F94CAAFE2FCF" modified="2017-10-25" version="1">MVIDLNSDLGEGYGAYTMGDDEALLDVVTSANIACGFHGGDPVIMRRTCDLAVAHGVRIGAHISYRDLAGFGRREMAVSPAELTAESIYQIGALEGFARAAGDRVRYVKPHGALYHSAASDPAAAEAVVAAMLTFGGLSLLGPADSELARAAEAAGIPFYAEGFADRAYTPEGRLVPRGRAGAVLAAEAALGQAVSIAVDGYAHTVAGDPVRVEVRSLCVHGDSPDAVRMARSIRQSLLDKGVELRSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2U7</accession>
    <name>A0A231H2U7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="2">2.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dlaT_2</name>
        <name evidence="2" type="ORF">B7C42_04602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009739.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43180">
        <property type="protein sequence ID" value="OXR43180"/>
        <property type="gene ID" value="B7C42_04602"/>
    </dbReference>
    <dbReference type="GeneID" id="66723514"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="8114" checksum="658854F5516B2770" modified="2017-10-25" version="1">MAHELLIPQLGVTMTEGTITAWLVEDGQTVQQGDLLYTLATDKTETDIESPAAGTLVIVGEIEVEYPVGSVVGRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2X6</accession>
    <name>A0A231H2X6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxo-5-alpha-steroid 4-dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.5" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43177">
        <property type="protein sequence ID" value="OXR43177"/>
        <property type="gene ID" value="B7C42_04599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="15"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="548" mass="57853" checksum="48CE706DDDDA9BDA" modified="2017-10-25" version="1">MSEQGPATTPEQVYDVVVVGFGGAGACAAIAAAEAGASVLVVDRFYGGGSTTHSGGVVYAGGGTPAQREAGVTDTAEAMFTYLAQEAGDAVGTATLRRFVDGSPGMIEWLTRQGVPFEGSLCPYKTSYPTNRHFLYYSGNEQVPSYADNAAPAPRGHRVRAKNFSGAAFYATLRDAALGKGIEFRPLAEVRELIVANGAVVGVEFDAPDPGVFGRRHKIRTEIAAKAEVWHPPLGDRLMAKVVSAQRKRSTRHRVLARGGVVLCTGGFGQNKELVRRHAPAWTEVSPLAAGGDDGAGLRLGAQVDAATSHLHKMSGWKFISPPSGFLEGVAVGMEGDRFANEQLYGATMSEPLIEQQGGRGFLILDAAGWRTARRQAREQSAFFQVPQSLYIFSPFGHRRAATVQALASACGIDPAGLAATVAKYNQDIEAGRPDRFGKADQYRRVLDRGPYFAVNLAPGVSPAYPFPFITLGGLAVDEDTGAVRRATGGTVPGLYAAGRAAVGICSNSYVSGLSLADAVFSGRRAGEHAARSGRDVEILESKNQETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H356</accession>
    <name>A0A231H356_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG_19</name>
        <name evidence="2" type="ORF">B7C42_04723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43301">
        <property type="protein sequence ID" value="OXR43301"/>
        <property type="gene ID" value="B7C42_04723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="25531" checksum="16C51B091AC8029B" modified="2017-10-25" version="1">MTDLFSLAGKVALVTGGSRGLGRQMVLAFAAAGADVVITSRKAEACEAVAKEVAALGRRALAVSCHVGKWDRIDALVEAAYAEFGKVDVLVNNAGMSPLAPSSAQTGEELFDKIVDVNFKGPFRLCALVGERMAAGEGGSIINVSSSGALMPQPGFGPYSGAKAGLNALTQVFAREYAPKVRVNTISAGPFLTDISKAWSEQARRFTPSAAGRPGDPAEIVTTALYLASPASSYTTASLIRVDGGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H381</accession>
    <name>A0A231H381_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase/lyase DddD</fullName>
            <ecNumber evidence="1">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dddD_2</name>
        <name evidence="1" type="ORF">B7C42_04731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43309">
        <property type="protein sequence ID" value="OXR43309"/>
        <property type="gene ID" value="B7C42_04731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="828" mass="88641" checksum="2D01BAB2E0E8430C" modified="2017-10-25" version="1">MTTGPDQGSSGPLAGLVVIDLSTTLPGAQASQFLADCGADVIMVDPPGGSDLRNLPGWPGLLRGKRSVTLDVRAGEDLATLRALLSTADVVITTMRPASATRIGLTPESLAEKYPRLVWASITGWGSSGPWKDYKGWEGLVMAKTGVMFEKRQLTIRPGPAFVTAPYASFGASQAAVHGILAALIERMSSGRGQAVESNLVTGMGAMDPYNWFYEMVLERYPDAFSPMDVAYDDAGRPQAYLIYALLIAATKDGRWLQFAQTAPRLMQAWLAELDLVKELADPKWTGFPMLPTPELRTEFWEMMLDRVGARTFEEWQQVFETNHDISAEAFRTPEEALDHPQVVAEGRVITVDNPAVGPVRQPSTLIHTEGKPLTVPGPAPLVGQHDDEVRAAVAAPAANRAAAVSNSSEESAAPQELPLHGVTVLEFGTMFAGPYGATLLADLGARVIKVEPIGGDNIRNLVAFPEAGGAKVLQGKESVAVDLTTPDGLELVYQLVRRSDIVLQCFRGAAAERAQIDETTLKAINPDIVYLSTPGYGVEGPYAARPAYAPSIGAATGLSALDGRDAANPPRDRDALRAGARTLHAAGAVPAVQSDGIAALGVASAMLVGLYAKRNGVELSNMVTTMLGTVHQALISYNTSYAGRPEIDVPDAQFYGLGALYRMYQAADGWVFLAAPLSSEWEALVKALSPYADLASDSRFSTVQDRHTNDAALADVLADVFAGKEKQQWEDELTALDVGCVAILERNSESALQSDPFFEAGYSVEAISPIFDEHRRLAPLTRFSRSRTKADAGCTVGQHTRPVLREIGIGEERIDELVELGIIACDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3F1</accession>
    <name>A0A231H3F1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036510848.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43400">
        <property type="protein sequence ID" value="OXR43400"/>
        <property type="gene ID" value="B7C42_04267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="71" mass="7805" checksum="700FF629F41E4E02" modified="2017-10-25" version="1">MATSYVPRSGLESMRLSIPTTALWLGGTTVLALLALYFIGIDQGAVSIFGDDMHVHEFVHDARHFLGYPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3N7</accession>
    <name>A0A231H3N7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="11" type="ORF">B7C42_04354</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43487">
        <property type="protein sequence ID" value="OXR43487"/>
        <property type="gene ID" value="B7C42_04354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="400" mass="42695" checksum="90B45F59946A6550" modified="2017-10-25" version="1">MSDNRSQVLEEPLVDESLPTADAPKHGFFERLYTGTGGFQIVGRRKLYYGIAAVLVLIAVLSIAVRGFTLGIDFAGGTKIQIPATSGMTTTSVEDTYSQALGHSPVTVQKVGSGSSASFEIRSETLDSAQQDKIADALFTKYHPTDASGTASRSVISVTEISETWGGQITRKALIALVVFVLLTMIYIAIRFERDMSIAAIASLFFNLIVTAGIYSIVGFEVTPAAVIGLLTILGYVLYDNVVVFDKVEENTRGVLHLTRRTYGEQANLAANQTLMRSINTTVIGILPIVGMLVIAVWLLGVGTLKDLALVQLVGMIVGAYSSIFFAVPLLVSIKERFGPVAAHTRKVLAKRAAGESGRAGETPARRASGAPVATRTRDSGSAAPRPGARPTGKRHKRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3U1</accession>
    <name>A0A231H3U1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">aroK</name>
        <name evidence="12" type="ORF">B7C42_04405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43537">
        <property type="protein sequence ID" value="OXR43537"/>
        <property type="gene ID" value="B7C42_04405"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR43537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="392" mass="41922" checksum="A47C4C50C169C8E9" modified="2017-10-25" version="1">MIVRSDPSRPSVILIGPPGAGKSTIGRKLARELGVSLYDTDAGIEQDTGRSIPDIFATDGEPEFRRIEERVVRRAILAEHGVVSLGGGAILSAATRELLRGRTVVYLEISVSEGLRRTGASTNRPLLNGDDPSAKYRELMRVRRPLYREVASIRIRTDGRSPGRVVRAILAKLGIEPAETPTPQQVSPSTEPTGTRRSRSRGRRRRTRAAADATQPTAASGETEAAQPDSPETDRTQPRRRARRSRRGGRRHSRNRTGTPPEAAPIGPAADRPTVTSEPAPGSADAKAPAAQPKARPGRVRRTATRAAGPPAASHNPGAIAAPHPEPARPVRSGPETQPAHAADDTPSPAARLAGETAQTAHDAVPGAGRSRRARARRARTRRALEESEQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H426</accession>
    <name>A0A231H426_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43532">
        <property type="protein sequence ID" value="OXR43532"/>
        <property type="gene ID" value="B7C42_04400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="4">
        <location>
            <begin position="45"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="21396" checksum="D5A966E018FA7D1B" modified="2017-10-25" version="1">MDKSENSEPSEPEPSRSGAAPEAGAARPDDIPAERPSARTDPGRGRRIGLDVGTVRIGVAASDPDGILATPVETVPTVKGGKRGPATDLIRVAEIVREYEAVEVIVGLPRTLRGASGSSAQMAARFARRLRDMIPGVPIRLSDERLTTVSAARALRDSGVRSRGRRQVIDQAAAVSILQGWLDERSAVLNSAGADEARWSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H472</accession>
    <name>A0A231H472_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_10</name>
        <name evidence="5" type="ORF">B7C42_04505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502493.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43637">
        <property type="protein sequence ID" value="OXR43637"/>
        <property type="gene ID" value="B7C42_04505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="310" mass="32990" checksum="7CB822E4F241FE19" modified="2017-10-25" version="1">MSAASEPAVCIDGVVKRYGDTTAVDGVAFEVGRAEVLALLGPNGAGKTTTVEMCEGFLSPDAGSVRVLGLDPVADSDRLRPRIGVMLQGGGAYPGSRAGEMLDLVASYAADPLDPQWLLDTLGLHDARRTPYRRLSGGQQQRLALACALVGRPELVFLDEPTAGMDAQARHLVWELIDALRRDGVGILLTTHMMDEAEQLADRLVIIDHGRIVAAGTPAEVTSAGAEGQLRFSAPPKLDLSLLESALPEGFAPSETAPGSYLLCGDITPQVLATVTAWCARIDVLPTDIRIDQRRLEDVFLELTGRELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4D9</accession>
    <name>A0A231H4D9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43576">
        <property type="protein sequence ID" value="OXR43576"/>
        <property type="gene ID" value="B7C42_04444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="309" mass="32761" checksum="FF4B11B65579D10D" modified="2017-10-25" version="1">MADVRPDLGFLELLVAIDDHGSLGAAARSIGMAQPNASRAVRQWEHRLGLALLRRSPRGSTLTPAGTVVVHWAREVLADLDRLLDAAAALRTDQEAELTIAASMTVAECLLPGWLGTFRRGHPDVKVHLQVHNSRQVCDRLVAGECDLGFVESPDVPDGLPHVTVAHDRLLVVVDPGHPWARRRAPLTVAELAATPLVVREPGSGTRSTLDVALAEYPRAEPLLELGSAAAIRTSVLGGVGPAVLSTLAVGDQLERGELRAVTVAGLDLRRTLRAVWRPPRKLGGPAGQLVSAIVHAQRAATPATPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4M5</accession>
    <name>A0A231H4M5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43814">
        <property type="protein sequence ID" value="OXR43814"/>
        <property type="gene ID" value="B7C42_04049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="30366" checksum="47AE97A94AE3507D" modified="2017-10-25" version="1">MREYLRSRRERLTPAEVGLPEAGRRRTPGLRREEVAVLAGVGVSWYTWLEQGRDIKVSGEVLDAVARALLLDEAERAHLYRLSGLNPPQREAAPSVPASPQMQALLDAWAPRPGYIRDRHWNFTAVNDAARRVFGYGDTDHNCLVSYFTNARYRVLHQQWAENAPGVAAGFRADSARYPDDPEFDRIATDLAQVSPEFAELWARHDAAEHSVAVKAVEHPEVGLLIFDATLFPVPDHPGHHLILHNPRPGTDTAERLERLLQPGGLTPRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4W4</accession>
    <name>A0A231H4W4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43911">
        <property type="protein sequence ID" value="OXR43911"/>
        <property type="gene ID" value="B7C42_04150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="23780" checksum="0BDFF585B9FB8B48" modified="2017-10-25" version="1">MTDTATCTLDGTGSRLRRARRMLGLAADIGLSPATYYLLIAAGCTSYRALVCSTVVAGIWALGIAAARRRADGVAVFVFLLNALGLVLAVLGGDERMMLAKDPITSAVISVLLAGSCVLGRPAMFAVSQSVHALGPDSAARWETLWHNDSDLRRTFTAATAVWSAGLAVDAVVRLLLIYSLPVSASVALMNPVQWAIIAALGLYTVRSRRRLDVKARLRALPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4W7</accession>
    <name>A0A231H4W7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43895">
        <property type="protein sequence ID" value="OXR43895"/>
        <property type="gene ID" value="B7C42_04134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="32973" checksum="D84DF0663C99BFF4" modified="2017-10-25" version="1">MDREELADFLRRRREQLQPADVGLLPGTRRRTPGLRRDEVALLAGMSTDYYTRLEQSRGPRPSVQVLGALARALRLSDDERDHLYHLCGHAAPHRGGGDRHVGPGLLYLLDKLEDTPACVVSDLGEILAQNRMHINMVGDHTRFTGMDRYLLWRWFTDPIGRETFPDADWDRLTRRHVADLRATAARRAGDADVTELVTKLRAVSPEFERLWSAHEVAVRISDAKRIRHPQVGLLDLVCETLVTPNASQHLLVYYPRPGTDAKERLELLRVIGTQSMTDDTDSGSTVFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H589</accession>
    <name>A0A231H589_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative quercetin 2,3-dioxygenase</fullName>
            <ecNumber evidence="6">1.13.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.24" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781082.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43896">
        <property type="protein sequence ID" value="OXR43896"/>
        <property type="gene ID" value="B7C42_04135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008127">
        <property type="term" value="F:quercetin 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="39"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="192"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="35715" checksum="6405C381EE3BAF7B" modified="2017-10-25" version="1">MSDLEANPAEALCESSPAPGPRADFHPAREVPLGGVRGVTVMRVLPQRDLPTVGAWCFLDHFGSTETSHRLPPDIDPHPHIGLQTVTWPFDGRIRHRDSVGSDVEIEPGQLNLMTSGRGIAHSEYTVPGAPAGQGLQFWIALPDAHRDIAPHFEQHRELPVLARPGLRATVLIGSLGEVRSPAITYSPIVGADITVGPGADAQLPLAPEFEHAVLVMSGEVRIDDVLAEPGPLLYLGSDRAELRLRSESGARVVLIGGEPFGEDLVMWWNFVGRSHDEIDAARTAWEKHDTERFGDVAGHTPQQRIPAPPLPNLRLRPRTRRTFPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5G3</accession>
    <name>A0A231H5G3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">metF</name>
        <name evidence="9" type="ORF">B7C42_03671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44114">
        <property type="protein sequence ID" value="OXR44114"/>
        <property type="gene ID" value="B7C42_03671"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="33630" checksum="EB10B46D569EDCDE" modified="2017-10-25" version="1">MVGQLGRRPDGTIPFSVEFNPPRDAAAEARLWRAAREFERMHPAFVSMTYGAGGSTRDRTARITGQLARETTLLTVAHLTAVGHSVAELRSIVGSYADAGIRNMLVLRGDPPGDPLGEWRKHPDGVEYAEELVRMVCELGDFHVGVASFPQGHYRSPDLDHDTRYLTAKLRAGAEYSITQMFFDVEHYLRLRDRVAAYDAEQGAKPIIPELMPITSLRTVQRAEELSGRPLPARVMQRLEQAAGNDPEANRNAVRAVGIEIATEIGQRLIDEGAPCLHFITLNFAKATTEVLTNLGYTVTPAAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5R8</accession>
    <name>A0A231H5R8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polyketide biosynthesis zinc-dependent hydrolase BaeB</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">baeB</name>
        <name evidence="2" type="ORF">B7C42_03612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063027503.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44056">
        <property type="protein sequence ID" value="OXR44056"/>
        <property type="gene ID" value="B7C42_03612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="28"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="237" mass="25879" checksum="145D6A13E055C1FE" modified="2017-10-25" version="1">MGSDRLYFRQLLAGRDWAVGDPIATQMRNFSYVIGDRESGECVVVDPAYAAGDLVDIAEADGLRLTGVLATHHHPDHVGGTMMGFTLRGVKELLERVQVPVHVNHEELSWVANVTGIAPSELTGHDHGDTLAVGGVEIEFLHTPGHTPGSQCFLFEDRLVAGDTLFVDGCGRTDFPGGDSDAMFRSLRHLAELSGDPVVYPGHWYSEEPSAALSSVRENNYVMRPTTLEQWHMLMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5X8</accession>
    <name>A0A231H5X8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44413">
        <property type="protein sequence ID" value="OXR44413"/>
        <property type="gene ID" value="B7C42_03202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="38572" checksum="1FCB70F6A933DACC" modified="2017-10-25" version="1">MVSPSRSSASPRQRDNAGKIVVGVLILLGLIASVFLIFSNNVQLVRVGLVAALWAAAVAALAATRYRRDAAIDQAKARDLQKVYELQLEREITARREYELGVESRVRREVGADAAELAALRSELTVLRESLQRLFDGDLLADRPALRAEAVRVQELTRATVANGSSQETDTWDAWSAPAVPLHVVSPVFDPDHPEPPAFASPYDDPVTAETAVVSAEASDEEGESPVRSPGSVSPESVSPGSVSPESASSKAGSSNAESSKVEAAGSESAQAAGDEHADPAATSAKSGTASANETSEPAGSGADSASESGDSRPNSAVPRLAPVRPATTMGTAGSRRRRHADSDEDQPGRKLTVAEIMANLRSEQNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D4</accession>
    <name>A0A231H6D4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator GltC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gltC_2</name>
        <name evidence="3" type="ORF">B7C42_03188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775686.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44399">
        <property type="protein sequence ID" value="OXR44399"/>
        <property type="gene ID" value="B7C42_03188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="32361" checksum="20CD2AB5B16DB094" modified="2017-10-25" version="1">MDPHLRDLRYFVAVAEELHFTNAAQRLHIAQPTLSRQIRQLERQLDVVLFDRNQRSVALTVAGKELLEGARRILELWEVTNVALQEAGEVLRVGIQSSIGRGLIAELESASGHRLALHSASWTDPSSGLAGRQADLALMWLPVPDSGRYRWQVLRTEARWVLLPENHRLADHEAIEFADLIDEPFIAMPAEAGAARDFWLGGDARGGRQAKIGGEAATAEERLEAVSLGLGVCLLAENNVPMYRWPGLTARPVAGLAPCELAMVWRADDDRPTILDFANRVVAGGFSVVEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6J2</accession>
    <name>A0A231H6J2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-6-deoxy-D-mannose reductase</fullName>
            <ecNumber evidence="2">1.1.1.281</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rmd</name>
        <name evidence="2" type="ORF">B7C42_03897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.281" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44336">
        <property type="protein sequence ID" value="OXR44336"/>
        <property type="gene ID" value="B7C42_03897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033705">
        <property type="term" value="F:GDP-4-dehydro-6-deoxy-D-mannose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="1">
        <location>
            <begin position="65"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="383" mass="41592" checksum="6775FCB19F72ED2C" modified="2017-10-25" version="1">MTLATSDTTPARRRTAPRLLIAGMTGQVGRGLAEALTDNPDPAAATAVVRRRTRADLDRAAVPRHQVIGDVAENLWGLDCSTLPEVDVVVDLAGIVDWTAGQAALDRINYLGALNGLALARELSDRLGRVVPYLYVSTAYVAGTASGNIAEDLHPAHPDRTPYELSKWFAEQHLIRRAAADGHPVLIARIGGVIGSSRTRSTTRWSSLYQLVTPMSSGQLPVLPVRPEARVDILPRDVIGEGLVRLLDHGAATDYASWRGGAIVHLVAGETAPTLAALLTVLQSKDITGRYDPPRLLVAPDRALRLAENLALKYARWNREMGNRLFGLRYVAIDRIFERTRLRALTDGWAPTYSVEDLIDVAFDLAPPVAPEPLPELPLGRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6M8</accession>
    <name>A0A231H6M8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44376">
        <property type="protein sequence ID" value="OXR44376"/>
        <property type="gene ID" value="B7C42_03165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="57" mass="6278" checksum="0C07F5EC00910B22" modified="2017-10-25" version="1">MIALGFAVAVGLPLIVLVAAILWPQRIPKDRTVAAIRQRVEDERRRDSNGGNGFHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6N5</accession>
    <name>A0A231H6N5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">panD</name>
        <name evidence="15" type="ORF">B7C42_03206</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775707.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44417">
        <property type="protein sequence ID" value="OXR44417"/>
        <property type="gene ID" value="B7C42_03206"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5011837737" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011837738" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR44417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="14956" checksum="EA354DA5A2EB11AF" modified="2017-10-25" version="1">MLRTMMKSKIHRATVTHADLHYVGSVTVDPDLMDAADLLEGEQVCIVDIDNGARLETYVIAGERGSGVIGINGAAAHLVNPGDLVILIAYGMMDEAELREYQPRVVFVDDRNRPVQLGSDPAHAPEGSGLTSPRSLTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H728</accession>
    <name>A0A231H728_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44659">
        <property type="protein sequence ID" value="OXR44659"/>
        <property type="gene ID" value="B7C42_03453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024495">
        <property type="entry name" value="DUF2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10969">
        <property type="entry name" value="DUF2771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013302766" evidence="1">
        <location>
            <begin position="38"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="19346" checksum="F2609E3E9FC72ACA" modified="2017-10-25" version="1">MTKPSTRTILALALAAVLVVAAAVAGIVAVAVHNAHEADPTVTAYAHGRTVTVPPYLYCTIGEPDPHGRVSPDCKRTEITAELNPPLGYPVQLSLPRHIADAPWVMVLEYQQIDNPGKTVQHLASYRDYPQGTRAVTVDSHPEPNLRLIGVEVQLLLLVRDEAGNEAFSPYQAWSIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H793</accession>
    <name>A0A231H793_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4,5-dihydroxyphthalate decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pht5_1</name>
        <name evidence="2" type="ORF">B7C42_03523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.55" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776287.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44729">
        <property type="protein sequence ID" value="OXR44729"/>
        <property type="gene ID" value="B7C42_03523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018796">
        <property type="term" value="F:4,5-dihydroxyphthalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="87"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="38530" checksum="DEC12EE2E08A9345" modified="2017-10-25" version="1">MTDPKLDLGVYRYEHTEPLFDGRVTIAGADVTLHTSPLISDVFRRMAERELDIAEFGLTYFLRAFDLDDSPFLALPIFPNRNFRHSSLFVNLDSGIEKPEDLVGKTVGEFALWGSDPGVWMKGVLAEEYGVTPDQMRWVIGGTDHAIPAFGWIPQPVPEGVDVRHAEEGRTLAAMLEVGEIDALLSVDVPAALLDGSTKKIRRLFVDYEAVERDYYRRTGIHPMMHVVAIRRQLAEQPGLAQSVYRAFDEAKTIVQEHYRVDAAKQHMSVITPWFSELFAENRALLGEDWWPYGLDANRKAVDTFLRYHHEQGLSKRLLTSEDIFVPGVEWATSPESGAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7J1</accession>
    <name>A0A231H7J1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ald_4</name>
        <name evidence="11" type="ORF">B7C42_02759</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 5"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44805">
        <property type="protein sequence ID" value="OXR44805"/>
        <property type="gene ID" value="B7C42_02759"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="10">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="9">
        <location>
            <begin position="163"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="312"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR44805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="386" mass="39528" checksum="38E5830133A52AF6" modified="2017-10-25" version="1">MIMAPRPDQGHDGGMRIGVPREIKPQESRVALAPAGAVELTRHGHRVLIESGAGLGSGFTDADYAAAGATIAESADAVWDEAELVLKVKEPVAPEYSRMRAGQVLFTFLHLAASRKCTDAVLASGVTAIAYETVRGPDGSLPLLTPMSEIAGKLAPQVGAYHLMAPEGGAGVLLGGVPGVRPAEVVVIGGGVAGTSAATVAVGMGARVIVLDTNPVRLRELDVRFAGRVTPLAANAADIERAVVAADLVIGSVLVPGARAPQLVPDTLVQRMRPGTVLVDIAIDQGGCFQSSHPTTHAEPTFAVANSLFYCVANMPGAVPHTATVALTNATLPYVRTIADLGWQEACRADPGLEAGLTADAGQLYSAAVARAHGLVGVGPGARWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H816</accession>
    <name>A0A231H816_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784192.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44932">
        <property type="protein sequence ID" value="OXR44932"/>
        <property type="gene ID" value="B7C42_02889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28653" checksum="B8B2B9FA1D4F1DFC" modified="2017-10-25" version="1">MTRPFRFGVVAPLMTDVPTWRDRVRRIADSGYSTLLVVDFPLTQPAPGPLLATAAALTDLRVGTWVYASPLRPPWQTAWEAHSLSLLTEGRFEMGIGTGRPGIEDELRDKGLPVVSPSERLAEVRKTVEALRDLDGPDRHTPVAMAVLGPKARALAAEVADTVTFALGDQSRGEVEKLARDFRIAGAPELALAVPVVGDTVAPHMAPPDTDPAALRAVDALAVLPDDPAAAAEEIQRRREEIGFSYFVFGADVAERLAPVVAELAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H858</accession>
    <name>A0A231H858_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent glucose-6-phosphate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fgd1_2</name>
        <name evidence="2" type="ORF">B7C42_03018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45061">
        <property type="protein sequence ID" value="OXR45061"/>
        <property type="gene ID" value="B7C42_03018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052749">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase (coenzyme F420) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="32918" checksum="82F1C1CD8FF4C910" modified="2017-10-25" version="1">MKIGIALTDFSWPVPGSGIGSAVTELAQAADASGIDSLWVMDHFFQIGISGHPPESPMLEAYAALGFLAGITDRIRLGTLVTAVPYRHPGVLIKSATTLDVLSGGRLIFGVGAGAPFDPEPMGPRTTFEAEGLGIPFPRLPRRFEQLEELLQIAHRMWSEDETPYRGNHYELARPLNSPNSIQRPHPPILIGGSGERKTLPLVARYADACNLFDLPRTGYADNLAHKLTVLRRRCDEIGRDYSTIEKTVTTALDIDAGHGPVLEHLKTLAATGIDHVILGPDGPWTPPRLERLIEIAPDIHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8K1</accession>
    <name>A0A231H8K1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_02468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513545.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45343">
        <property type="protein sequence ID" value="OXR45343"/>
        <property type="gene ID" value="B7C42_02468"/>
    </dbReference>
    <dbReference type="GeneID" id="66719113"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23501" checksum="8D8BBD62FC9CB57F" modified="2017-10-25" version="1">MARSVVGKPPRRTQEQRSSEMRVRLLDATIDCLVEYGYAGTTTPRVAERAGVTRGAQVHHFGSKTDLVVAAISHLAQRRTEAAMKELGRLRAGDDPIGATLDAMWELHQGPLFIAAMELWVAGRTDPVLAAEAEKVEPFVNNAVLMAVSQLVPDELRRKEVRDFAYTAMDTLRGILVSNFVSPDPERAHRRWQRASAHLRRAAESALPGLGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8X5</accession>
    <name>A0A231H8X5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45281">
        <property type="protein sequence ID" value="OXR45281"/>
        <property type="gene ID" value="B7C42_02406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="57" mass="5959" checksum="525B826BB1F73E7B" modified="2017-10-25" version="1">MTYASTAMRRSTRLVTQLLITAIAIAATVLFTYALQHSVSTGPVHSGHTSAPTSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Q8</accession>
    <name>A0A231H9Q8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45476">
        <property type="protein sequence ID" value="OXR45476"/>
        <property type="gene ID" value="B7C42_02601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11663" checksum="53E75EFDEC38FEB9" modified="2017-10-25" version="1">MSTATTRSGAIAVETTEQGLPLRISIEASELRRDPAELAAELLRLCSRAADRAGLARRRQLAEAGVSGDLLALTGLPTAEQVERQELIDEQEYDTEPQSWLRSVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9S9</accession>
    <name>A0A231H9S9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpx1_1</name>
        <name evidence="7" type="ORF">B7C42_01882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783973.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45590">
        <property type="protein sequence ID" value="OXR45590"/>
        <property type="gene ID" value="B7C42_01882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19498" checksum="26FEBD43BBFD3256" modified="2017-10-25" version="1">MTIHDFSVTTADGEDRSLADYAGRVVLIVNVASKCGFTPQYEGLEALYKKNRDRGLEILGFPCNQFGAQEPGADAEIQEFCSTNYGVTFPVLGKIEVNGPDADPLYTYLRAEAPGDFGPSAGPLYDHVKATRPEAIGTDEVKWNFTKFLVGRDGKVIRRFESTVTPEQIETEIAGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Y6</accession>
    <name>A0A231H9Y6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lgrB</name>
        <name evidence="10" type="ORF">B7C42_02642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45517">
        <property type="protein sequence ID" value="OXR45517"/>
        <property type="gene ID" value="B7C42_02642"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="2057" mass="223094" checksum="5C18C09779A4F7FB" modified="2017-10-25" version="1">MRSLEDLQVAMAARLAEEGLATAAAVPVRRNPQRAPLSFGQRYVWAHQQISPGSSAYNLCLALTFEGAVDAEPIDAGALRAAFAALVERHEVLRTTYHTDADGEPYQRIHADLPPRLMEEDLSGLAGEQARRRLRELTEAAARETFDLTAESSLRVTFVRMSAVELVAVVVIQHIAWDGMTLPALSRDVENFYRQALTGPVTVEPLRLQVADFAEWEADRFAAEDHAEDIRFWQSRFDGELPELQLPYDRRPVAATERGARCDRPLSAAADTALRRLTAELRTTPFSVFLAAYYVALREMTGRGDMVIGTTVANREESGMELLIGNLSNMLPLHIAGRDDQRFAELVEQVRGVITDAFGHKHFPQEGIVRAVNAATGNVGSNLFDTMVLFLHQKIDGPQLPGVTTSWELMDNGAALLPLVVETFMHGDRTDVQITYRTDLFDAVTIDRLHEYIDLVLAAATADRRVSELATLSPTDRAALAQWSHGAAVPIEAETADAMIRASARTYPDRTAVVFGDIELSYREFDTRVNRLARLLLEDGVRPGDRVGVYAERSERLPIAFAAVLRVGAVYFPIDPSYPIDRIEYMLGDAEPALLLTSAVKALSVETAVPTVDLVDPHVIERLSALDGSELSPAALPRPLHPLDPAYLLYTSGTTGRPKGVVIHHRGIANHVQWMRDYLGFGAERILQKAPIGFDVSVFELVNALCTGSATVLPPPQWWQADVEALAEIIHRHRITQISLVPSVVRAFIDAGPDPARLQSMRYVYLGGEAVPPALVEESSRFFGGTVLGLYGPTEGSMDLMHEDFAGRTNTEATAGTALEPALIGLPEWNSSVYVLDERLRQVPPGVIGELYLGGVQLAQGYHRRPDLTAGAFVACPFAGEPGARMYRTGDIVRWNSQGRMEYLGRVDDQVKVRGHRIELGEIGTVLRCVPGIASAVAITVPQSAQSHDLALVAYYVPEANSEFATGGDAENTERIKAALAQRLPEYMIPTALVKLAALPLTANGKLDRRALPQPDLGGSTGHGRQLRAGAEAAVAEVVRAVLHLGDSTALAADDDFLALGGDSISAIRMASALKKYGLLITTSALFDARTIARIAAACEQIVESSGPALVEAESPAGWIPLNPIAALLTEQSGDYHAYTQATAVVAPAHSTREQIAEVVSALAARHPMLRARLGTDPQGATAYYVPEPDEPTAAPAVAEIVIGDESWDRTAGARLNEQLAELSARLDPAAGRMLAAAWVHSADGTQGRLLLVVHHLVVDGVSWRVLHDDLRGLWGVAAATVEPQPGTSVKTWNTSLVHVANSDAVLATLPYWRGAAEAVDPLLGGRALDPAVDTVATVREVTATLDADDTAFLMSTATTAFGCDFLDIQVASLAVAIHRFRRRRDRDAEAVAVTMERHGRVETLFSGVDLANTVGWFTTTYPVSLRIPDAGEQVESAVKAVKEQLLAVPESGIGWGLLSRLNPATRAELAGSPSPQVSFNYMGRFAASGAADRESVRTWDAAPEFGYMGGHADPAMPAPALLDINTVALADGDSVRLHASFRFPAGPLSDDEAGELAQLWTEGLGELVKSVRDNPVRRLTPSDVVADEVTQLDLDRWQALYPGCVDIYPLAPLQAGLYFTALGSAGNDVYNVQTLIGVRGALDLPLLAASFATVLNRYPNLRVSISVSHAGQPYAVVADHMRIPVREIDFADLPDARQRLQEFFRADQAEHFDLTRGPLLRVTVAHLPDDHHMVVLTSHHLLTDGWSGQLLPREIFAEYAGRGGQPLGDPETFARFLRLTRDREQATEAAWQSYLEDVRPCLVAPARTPDSGGVPEGRTFVLDDDTVARATELAAAQGTTFSLVCQLAWANALRYVTGEQATVFGEVVSGRPADLDGVDHAVGCFANTIPVAIDLAGDRTWRDHLAEMQRHRVELMEYHQYRLTSAMRAAGGSGTAARKLFDSMFVFQSYPPGRDELETSLREGGLELVSFEGGGATDNALLLMIFPANSLLPGDAVQAVVFYAEDSFEADDARIVETAFRNTLRAIAEQPDRAVADTTVIDDEDQGLLVMRRMWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA98</accession>
    <name>A0A231HA98_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="10">PEP synthase</shortName>
            <ecNumber evidence="6 10">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppsA_3</name>
        <name evidence="14" type="ORF">B7C42_02051</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6 10"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45759">
        <property type="protein sequence ID" value="OXR45759"/>
        <property type="gene ID" value="B7C42_02051"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="365"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="464"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR45759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="776" mass="83679" checksum="9064209062B65024" modified="2017-10-25" version="1">MGDYVASLNDIRLTDAGQVGGKGANLGEMVAAKLPVPPGFVILRSTYETAVADGPHGPEIDSLHAEALRSAVAADNAGRAQLDLLCSRMRDLVHETRLDGAIEEAIVNGYHRLGDRVRVAVRSSAVGEDSADASFAGMNLSRTNIRGDAELLDAVRQCWASLFTPRVLTYRARRGMDRRPEMAVVVQQMVTVRCAGVAFTADPTTGRRDRVVIDAARGQGEVVVSGAVEPDTYVFAANGPMLTESRRGAQSFAIFADEDGDRRVDLPDDESHRPVLTAEEATAVARLALEVQQHYGRPQDVEWAFDDQRLWLVQARPITTLPDETPSAAPEETPAAVLLQGLPAAPGRARGAVRILRSPAEGSALRDGEILVAPMTNPDWLPTIARAAALVTDSGGMTCHAAIVARELGIPCVVGARTATTSLHDGQRIVVDAKAGRIRADSPEERAAEAATASAPAATTTMPAAAPVTETTGTKIYVNLALPEIAERIADSDVDGVGLLRAETLLTRALGGRHPRAVIAAGDENEFVATLAESLRRIAVSFAPRPVVYRATDLRSNEFRTLTGGEGFEPNERNPMIGYRGCYRYVHEPDVFRLELAALARVREYTPNLHLMIPFVRTRWELAACLELVDASPLGHDRGMHRWIMAEVPSVVHWLPEYVRLGIDGVSIGSNDLTQLILGVDRDSEECAELFDESDPAVLHAIRRIVTSARELGITSSLCGQAPSTRPEFAEHLVAAGITSISVTPDAVRNARRTVAAAERRLLLERCVHGDERRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAE1</accession>
    <name>A0A231HAE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45706">
        <property type="protein sequence ID" value="OXR45706"/>
        <property type="gene ID" value="B7C42_01998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013031314" evidence="1">
        <location>
            <begin position="35"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="17190" checksum="B8D53E214BBB3D1F" modified="2017-10-25" version="1">MRNKMIRGAAGLCGIAVIAAATVTGCSDDKSDNASSTTTTTAAAATTSAAAPAAGSSAADPATTKAVTDAYVLFFDAKQPADKRAAAVEKGDVFAPVLAAQAGNPQAQGTSATVSKVTTVDADHADVTYTLLMGGNPVLPDQAGQAVQENGQWKVAATTFCALLKLQGGTAPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAF0</accession>
    <name>A0A231HAF0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysQ</name>
        <name evidence="1" type="ORF">B7C42_01999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45707">
        <property type="protein sequence ID" value="OXR45707"/>
        <property type="gene ID" value="B7C42_01999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="25365" checksum="097FC3362CCA52E4" modified="2017-10-25" version="1">MDDHAVAAELAREAGELLLEIRDQGGAVGDRRSDELLLKRLAELRPDDAVLSEESTDDPIRLSRSRVWIVDPLDGTREYGQPPRADWAVHVALAVDGRAEIGAVALPVPGLVLETGAPPVLPPAHDGPPRIVVSRSRPPACVHHLTAALGADTIPMGSAGAKAMAVVRGEADIYAHSGGQYEWDSCAPVAVAAAAGLHTSRLDGSPLIYNQPDPYLPDLLICRPELAEEVLEALRDFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAH7</accession>
    <name>A0A231HAH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GTPase</fullName>
            <ecNumber evidence="3">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45964">
        <property type="protein sequence ID" value="OXR45964"/>
        <property type="gene ID" value="B7C42_02257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="40571" checksum="5F3793D81F395BC3" modified="2017-10-25" version="1">MSDADRSPAGDAPAGAGLPANAELPGTQALSTARGLPPALRVDGPQSQGGGRRRTIDVAELAGAIRDNQRAALARAITLVESTRADHREAAQRLLLELTAEAGAAASNRVGITGVPGVGKSTFIDALGMYLIGQGHRVAVLAVDPSSTRTGGSILGDKTRMARLSVEREAFIRPSPTAGTLGGVAKATRETIVLLEAAGYDVILVETVGVGQSEVTVANMVDVFCFLTLARTGDQLQGIKKGVLELADLVAVNKADGRHEVEARAAARELQGAMRLIHPRESLWRPPVLTMSGLNGTGLDTFWDTVLEHRRVLTEAGEFAEKRRRQQVDWTWTMVHDQLLRRLADSPGVKAIRAQVEKQIRDGSLTPALAAEELLRAFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAH9</accession>
    <name>A0A231HAH9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetoacetyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.1.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phbB_1</name>
        <name evidence="1" type="ORF">B7C42_02127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.36" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45835">
        <property type="protein sequence ID" value="OXR45835"/>
        <property type="gene ID" value="B7C42_02127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018454">
        <property type="term" value="F:acetoacetyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="24943" checksum="6646FA0F0C260AB4" modified="2017-10-25" version="1">MGVRTAVVTGGGSGIGLAVANRLRADGFRVATLDIKPGDSEFDHTADVTDRAQIDAALTAIREQLGPVTVLVNSAGAEGYRRFANLSFEQWERTIAVNLHGVFHSIQAVLPDMRAAQWGRIVNISSSSTHSGQPFMSHYVSAKSAVNGLTKSLALELGPEGITVNAVPPGFIDTPMLRKTEQAQLLGGTIDDHIARTPVRRVGRPEDIAAACAFLVSEEAGYITGQILGVNGGRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAY9</accession>
    <name>A0A231HAY9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_02292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778057.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45999">
        <property type="protein sequence ID" value="OXR45999"/>
        <property type="gene ID" value="B7C42_02292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="25125" checksum="85877E8090CD892A" modified="2017-10-25" version="1">MSTPRSRARARTMDEIVRIGREHLAVHGAAALSLRAVARDLGVVSSAVYRYVRSRDELLTMLVVDGYTELADAVDAALAAAPADGATRLRVLAHAVRDWALAEPARYGLLFGTPVPGYDAPAQETTAPGTRVIGSLLNIVETACRTGELATPDPIPAVPAELAADIERIRAEFGLEMPNWAMARTLTVWTGLFGAVSFDVFDMYGAQTFTDRAQVFDVHLDTLCAILGFPAAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAZ3</accession>
    <name>A0A231HAZ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778149.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45897">
        <property type="protein sequence ID" value="OXR45897"/>
        <property type="gene ID" value="B7C42_02189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="15544" checksum="C280C2AFE0DC25CC" modified="2017-10-25" version="1">MSDFDSNGPTPRLTAPLCRAARLLGDEVRAVLLHSPRPVFLFYLAQTFDQLEADLSSGRPPGPATPAQQLCLHLMLAQAEGQVPAEELSRARRRLLRHDTGEILAEVRAVAGKSGGSYDFIALGDVLAAGGMGAFFAPFEPSDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB58</accession>
    <name>A0A231HB58_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778016.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45957">
        <property type="protein sequence ID" value="OXR45957"/>
        <property type="gene ID" value="B7C42_02250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011283823" description="NMT1 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="38350" checksum="4D66402EE768DBB0" modified="2017-10-25" version="1">MSFRRPRVVRALAAVLALPVLAALAAGCSSSGAGTTADGKTILRYQGQAGTVTPYELAADLGYFSKIDLKWVGDTTSGPANIQAATTKQIEFGSAFNGAVVKLIAGGAPVTSVLSSYGADGQSFTGYYVRDDSGIKTAKDLIGKKVGVNTLGAHHEFITRQWLHDQGLTDDEIKQVQLVVLPPVNTEDALRKGQIDVAALGGPLQDIALAHGAIHPLYTDKGLFGEFDYGTYVFRNDYIADHQDAVADFVQGTARATRWLQITPHDQAVARLADIIHKRGRNENTKLLDSYKSSGIPVPGAVIQERELQIWIDWLVRNGELPAGKLAAKDLYTNKFNPYANGKYPAESGPTGEVVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA6</accession>
    <name>A0A231HBA6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46160">
        <property type="protein sequence ID" value="OXR46160"/>
        <property type="gene ID" value="B7C42_01125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011307892" evidence="1">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="26847" checksum="0D5ED3179AC9C228" modified="2017-10-25" version="1">MKLRRGTAVAAMVIGAMTVALGTANADPAPAPAPAADAKPGIDYSTKLVDKTVVTKLKNGTFELVEKHGATPDQKQQVVDIKDQAGNVALEMPIDYRIAGVQIPIKPVLKDNGTVLELTPDKPGNVDLTKPVAAAPVAAVADTKADQQTPIQADKPVLVAKDVASPIENQRAMSDFATKFGLATAIGGFVGTAIGAVIGCVVTIVAGCIPGLVTGAGVGGIVGTVAVGGPALVAAGVELVNTMQAADGSTQWSDAAMAAASGQPQQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBB0</accession>
    <name>A0A231HBB0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dmpP_1</name>
        <name evidence="17" type="ORF">B7C42_01103</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781449.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46138">
        <property type="protein sequence ID" value="OXR46138"/>
        <property type="gene ID" value="B7C42_01103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="15">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="142"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR46138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="42831" checksum="8D4D401B3BCDED4C" modified="2017-10-25" version="1">MDARSAALVRANFRSILEAPQGPERLIGAFYRHLFAEAPGLRDLFPHTMDMQPKRVCTAIQFVLDHLENWDRAQGFLEQLALDHRKYGVEAAHYDAAGRALLAAFVTYNGPLWTPDLEDGWRDIAILISASMAIGANSDTSRPYWEATVVGHRRVLDDLAIVRLQSDEPIPYQAGQYVPVSIPQRPKMWRYLSPAIPTNPYGEIEFHVRKVRTGWVSPAIVGETEVGDTWLVAGPLGGLHIDTESQRDVLMIGSGTGIAPLRAQLIEMGRRGVNPRVHFFIGGRYPCDLYDVENMWQLSLSNPWLTVVPVCESDTNPWWHPHPPADPPYGMHRRLIGNLGAVVASFGSWSDRQIQIAGSARMIADTKRALLAVGTPEHIISADPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBC3</accession>
    <name>A0A231HBC3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactate utilization protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lutA_1</name>
        <name evidence="7" type="ORF">B7C42_01126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46161">
        <property type="protein sequence ID" value="OXR46161"/>
        <property type="gene ID" value="B7C42_01126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="752"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1100" mass="114838" checksum="705BF73A4164356D" modified="2017-10-25" version="1">MNALTVTLGTIGAVLSLVCWASFIGGAWKIFSAIRVGQPAPDRWRPFFPRLKTMLVEFIAHTRMNKFRTVGWAHWLVMIGFITGAILWFEAYGQTFDPEFHWPIIGNWGVYHFWDELMGIGTVVGILTLITIRQLNHPRVPQRLSRFSGSKFGPAYVIEAIVLMEGLGMIFVKAGKIALNGEGNPATDFFTMRVAELLPANATMVSIFAFIKLMSGMAFLYYVGRNITWGVAWHRFSAFFNIYFKREDDGGVALGAAKPMMSKGRALDMENVDPDTDTLGAGRIEDFSWKGWLDFTTCTECGRCQSQCPAWNTGKPLSPKLLIMSLRDHGAAKAPYLLAGGRKDMGGDEVGLVDAEGKPNEAALAKISEAAKAEAERPLVGGEDVNGIIDPEVLWSCTTCGACVEQCPVDIEHVDHIIDMRRYQVLIESEFPSELAGLFKNLENKGNPWGQNAKDRLNWMSELDFDIPVFGQDAESFDGYEYLFWVGCAGAYEDRAKKTTKAVAELLATAGVKFMVLGAEETCTGDSARRAGNEFLFQQLAMQNIETLNSVFEGVEPSKKKIVVTCAHCFNALNNEYPQVGGTYEVVHHTQLLNRLVRQRKLVQVKPVSEKVTYHDPCYLGRHNKIYNAPRELMAASGANVTEMPRHGERSMCCGAGGARMWMEEQLGKRVNLDRTDEALATLDGGNSPSLIATGCPFCRVMLTDGVTARKDSGEVGQGVEVVDVAQLMLQSIDRVEPAALSENLKVIQQPKAPEPVAETAAPAAEATAAPTAEPEAAAPAEQAAPAAGKGLAMKGGGKAPGGGGLAMKGGGKAPGGGKGLAMKGAAKAPGAKATPEPEAAEASTEAPAEAPAAKPGGLAMKGAAKAPGGKGLAMKGAAKAPGAKATPKPAEAPAAEAGAAEAPAAESTETPAAPTAKPGGLAMKGAAKAPGGKGLAMKGKAKAPGAKPANEAPAEAEAGAAEEPAAEATPAQAPAETASAATGPTETKPTVAPKGLAMKSGFKRPGPKAPGAAKPAAESAPAATESGNGAAPADAAGSEAAEPEVPATESASASEAPKSAPAAATESADGGNGEVQPPTAKPGGLGFKSGAKAPGSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBQ0</accession>
    <name>A0A231HBQ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46176">
        <property type="protein sequence ID" value="OXR46176"/>
        <property type="gene ID" value="B7C42_01141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="33470" checksum="BE8DBEF916AEFF85" modified="2017-10-25" version="1">MADERASLPRRQLGRFVRRQREENTSLTQEAVAKAMQWSHSKYARLERGEPGKVLDRDLVELGKILEIPENQVGAMIELARQVAEKTWYNSFNDLIRANFDVYMRLETDARSMEIWRPDIVPGLFQTADYASALNRIYFPKESEEEHARRIQLKLQRQKILTRKKAPVVVDLVLHESVLHTVVGNHSVTASQLRHLADISTRPNVTIRVLPYSVGFPLGTPVGPFAILDFEASSNGVAEPTVVYVENYTGDMYLEEDADVQRYRRASATIQHTALDAVASRTLLRRAARKDATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBT1</accession>
    <name>A0A231HBT1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamine transport ATP-binding protein GlnQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnQ_2</name>
        <name evidence="6" type="ORF">B7C42_01274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46308">
        <property type="protein sequence ID" value="OXR46308"/>
        <property type="gene ID" value="B7C42_01274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="39"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="275" mass="29271" checksum="84BC9DAF2DFA49A4" modified="2017-10-25" version="1">MSDQNPKGVSDRNPKGVSDQNPKGVSDRTSAGVGTSSSLTGVDLHLTLGNNQVLRGVDIHVEAGHTTTVIGPSGSGKSTLLRVLNRLHEPDSGDVLIDGVSVLGENPDRLRQRIGMVFQHFNLFPHKTVAENVALGPRKLRGLSKEAARALALEQLEAVGLAARADTRPANLSGGQQQRVAIARALAMKPELMLFDEATSALDPELVKGVLALMADLASGGMTMIVVTHEMGFARSVSDSVVFMDQGKVVESGSPERLFDDPETPRLQQFLSQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCC1</accession>
    <name>A0A231HCC1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46416">
        <property type="protein sequence ID" value="OXR46416"/>
        <property type="gene ID" value="B7C42_01382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624275" evidence="1">
        <location>
            <begin position="28"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="173" mass="16820" checksum="49D189CC340B66ED" modified="2017-10-25" version="1">MKVTSAITGWAVAAGAVVCWATGTASATTVHCDADRNRDITIIADTTACRATGDNSGHARSAGIDGVGYAKATAGAIALGLGAGGGIGASEGAAGLPVAVGMGPDAFAFTSLAPEPAPGRIGLSFAMNGSQAQVVSGERSTVCLGSAALAWDSRTGAICLATPFGLWQVPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCD3</accession>
    <name>A0A231HCD3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">drrA_3</name>
        <name evidence="7" type="ORF">B7C42_01437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781834.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46468">
        <property type="protein sequence ID" value="OXR46468"/>
        <property type="gene ID" value="B7C42_01437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="35797" checksum="8EA9979B46F4A0A6" modified="2017-10-25" version="1">MPDAIIAEGLVKKYGRLVALDGLDLAVPEGTVTALLGPNGAGKTTTVRVLTTLLTPDAGRATVAGIDVLREPQRLRAHIGASGQYAAVDEYLTGFENLEMVGRLYHLGIQRSKQRARELLERFRLSDAADRPVKGYSGGMRRRLDLAGALVANPPVLFLDEPTTGLDPRARLDLWDVIEELVAGGTTLLLTTQYMEEADRLADAIAVIDHGTVIARGTADELKTLVGGDRIELTVEHADVLAVAQQALAGLAVGDIHVEPGLRRLTIPVDDGSQALVDTIERLSAHRVRIQDVGLRRPSLDDVFLTLTGHEAADSIDPADAAQTLEQATEGHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCK9</accession>
    <name>A0A231HCK9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036507346.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46407">
        <property type="protein sequence ID" value="OXR46407"/>
        <property type="gene ID" value="B7C42_01373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="124"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="41721" checksum="72C6B6357AAE663A" modified="2017-10-25" version="1">MSWLLRHKLLLSTIGLVIAFVVGATYLAVDVMRINPLRSTYTVTVALDRSGGLQPGNDVTLRGFRVGKVNSIKLADRGASIAAEAQIDTRYKIPKATQVVVHALSAAGEQYIDFQPETDKGPYLTDGSVIPFDPQKVQTPTPVSAVLENASGFFDQIDPDRFSTILTEFDTALSGGPDQLRDMVDALSLVTAGLDNLLPQTTNLLTSLRTIAATTSNAQPDLSTLTQNSSTLFIQFNNANDELRKVLDQAPAQMKSLGATLDETTDPITSLATNFVAVTKAAQLRLPALRALFPSLVVGSSAMGVPAHDGEFYTILDIWPRPFCQYSHAPVAPSVVTDGSFPKYNYCTNAPPDQQIRGSANAPRPDVPNNGAQMPSGADPNARTPKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCQ0</accession>
    <name>A0A231HCQ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46684">
        <property type="protein sequence ID" value="OXR46684"/>
        <property type="gene ID" value="B7C42_01659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11897" checksum="86D3046DA8A08B6B" modified="2017-10-25" version="1">MLSEFSAVPWDTITVEGVLLLFMGIIVGGRLIPRSWVKSLLAEKDARIEYQETAMAEQRATIASLVQQNAELTVSGRLSVALLQSIQTTATSNHTSTTDPGSGHVAPSVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCR8</accession>
    <name>A0A231HCR8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46586">
        <property type="protein sequence ID" value="OXR46586"/>
        <property type="gene ID" value="B7C42_01557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="631" mass="68415" checksum="C89C58A48D5F58D4" modified="2017-10-25" version="1">MVQGGPAVPDEQRPGVSAAVLSEGHQLRPLDPALGDRPSRGARLRDRLLASRADLVVAAVYLTAAVYVLSGQWRDTAHGYLVASGQDQSMWEWFFAETAHAVIHLHNPLGTNLQNYPDGVNMMANTAMFGVGIPLTPVTLLFGPTVTFALVLTLGLAGTGFAWYWLFSRELVSSRFAAALGGAFCGFAPAMVSHANAHPNFVGLAILPVLAVLVIRMARRAVRGEPVTRARRVREAGVLAVLVALQIALGEEPLLIFALGFGLFALVYYLHRPRTGLRVARAVTPTLALAAVITVAAAAVPLWWQFFGPQSYRSIDHGPMGNDLTALVEFPSRSLGGVFAPAETPAINPTEENAFFGWPLLVLTAVTAVWLWRSRNREYRVIRAATTVIAVYSILSLGVSLRIGRSDTGITLPWHWLDQVPLLNTVLETRFTMAAIPALAAILALGTQRILYYARSGTNDLRPVIWFTAVALALIPLVPTVLPVTHRDPTPRFFTDGTVDRYVGDGSVVIAPPPTRLDAQPLNWQVDSHFDFPLAGGYFVGPTAGKKGRYGPDDRPTATLLMRAQKTDRIQPVDVRARTRALADLAYWHADVVVLPPTEHGGAIRATLDQLLGIPGQVVDDVVVWDVRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCY6</accession>
    <name>A0A231HCY6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46557">
        <property type="protein sequence ID" value="OXR46557"/>
        <property type="gene ID" value="B7C42_01528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="368"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="412"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="628" mass="67481" checksum="4672EAF69FB0C656" modified="2017-10-25" version="1">MTDRTTESADRADSRRATTAPLLEVSDLHVSFPGEEGRIDAVRGVNYTVADGEVLAIVGESGSGKSVSSLAVMGLLPDQARIRGSIRLRGRELLGMGDKQLSALRGTRVSMVFQDPLSALTPVYRVGDQIAEALVAHKKMSKSQAADRAVELLDLVGIPEPAVRAKAFPHEFSGGMRQRVVIAMAIANDPELIICDEPTTALDVTVQAQILDLLRKARDITGAGVIMITHDMGIAATLADRVAVMYAGRIVENAPAAELFNSPRMPYTVGLLGSIPRMDGPARAPLIPIVGAPPPMHALPPGCPFAPRCPVSIDDCLAAEPPLQETAPAHRAACIRTAEVGTAELFAAYRHDTDSVAAAEPVDSDVVLRVSGLTKTFPVTSGVVFKRRTGEVRAVDGIDFAVRKGRTLALVGESGSGKSTTLSQIMDLAQPEAGTIEVFGADVATLSKQRKRDIRRRLQIVFQDPSSSLDPRLPIFDALAEPLRVDGRSRDEIRKRVPELLKQVGLRAEHADRYPADFSGGQKQRINIARAMALDPDMLVLDEPVSSLDVSIQAGVLNLLRDLQAERGLSYLFVSHDLSVVRNLAHDIAVMYRGKIVESGPAEQIFAAPQHEYTRALIDAVPLPVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI7</accession>
    <name>A0A231HDI7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46939">
        <property type="protein sequence ID" value="OXR46939"/>
        <property type="gene ID" value="B7C42_00055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="36241" checksum="9CBC85C872E038C5" modified="2017-10-25" version="1">MQQVRQPATGVKAVLGRIRHSDTLLGTVVVLVAVIALAAAGLLYMRPMHQKTVRFETTDASSINVGESVRVAGIDVGKISKVSMRPATVQVEARISDSTFVGTDSTVEVRMLTPVGGYAVTVVPAGTKALGEKVIPVDHVSVPYSIGDVLQAVPHTTDNVKGGTIDANIDQVAEALQHNSSSVSSIIQGMNSIATVMDHQREQVRTITDLASEYLQSFNGSREWVFELLRKSDLVLTTYDNTHVGFNEAYRLLGDVLYRVTPVMSFLLEHNPEIKPVIEKLRSSITDIQTSMGPALEQLENLRDRLAAWLGPDGLATLGGGTISASDICVPLPGRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDQ8</accession>
    <name>A0A231HDQ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protease HtpX</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">htpX</name>
        <name evidence="10" type="ORF">B7C42_00200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47080">
        <property type="protein sequence ID" value="OXR47080"/>
        <property type="gene ID" value="B7C42_00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="139"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="368" mass="40395" checksum="F561A9D4756E3677" modified="2017-10-25" version="1">MQSEDQWADQSPQQGRGPGWNPVTGMAGWDPRLGPPGWGPQQPFSPPHVPPFQPTRGLSPWGMPARHSWEIPLLIVVILVTVTGYLIALLFLLVGAVNYYVVLVTLAPLLLWFGRGTNYSMQRLNAVKMSPTQFPEGYRMVVEAAARFGMATVPDAYVVLGNGQINAFASGHGFRRYVVVYSDLFEIGGQARDPDALAFIIGHEVGHIAAGHVSYWRQLGMFLVPFLPIIGNSLIRAQEYTADNHGFCNRHLGAPGAMKTLAGGKYLNSLVDFDEMADRAPQDKGFFVWVVNAMASHPVLTWRMWALRDRSRHGRMFLRPSGPPPPRMTATPPPYPPAGPPQPMPPAGPDDRTGSYPGYGEIPGLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDS9</accession>
    <name>A0A231HDS9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-CoA:coenzyme A transferase</fullName>
            <ecNumber evidence="2">2.8.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cat1_1</name>
        <name evidence="2" type="ORF">B7C42_00098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46982">
        <property type="protein sequence ID" value="OXR46982"/>
        <property type="gene ID" value="B7C42_00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="1">
        <location>
            <begin position="263"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="420" mass="43870" checksum="CDB87109578D2167" modified="2017-10-25" version="1">MSVIVEHMDAASALALVGDGAHIVAGPGCGAPTTLLRAVNKQAPGRGWTLDSGMLLGDYPFLDVVRSGDLRYRTWHVMAPVRELVADGVVGYVPIRASRVAGLLAAHGVGAALVRVTPPDRHGYCSLGPSAGYGLDALRLAGMRIGEVDPDLPRTHGGTTVHRSVFDALVETEDPTPRYESAKPDAISKQIAAHILGLLPRDPTLQIGIGSIPEAVVSSLATADVGRVRFAGMATDEMVDLFERGIIAPEVDESPITSPELMGTERLMRFADGNPAVSVYPSSRAHDAALLGRIERFVSINTAIEVDLSGQVNSEMIRGRQVSGVGGSLDFVDAASRSPGGLRVIALPAATANGVHPKIVGAIGASGTVTMPRSMVDAVVTEYGVAVLEGLTSVERSEALIAISHPQHRAALTEYAGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE10</accession>
    <name>A0A231HE10_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47180">
        <property type="protein sequence ID" value="OXR47180"/>
        <property type="gene ID" value="B7C42_00302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005509">
        <property type="entry name" value="AfsA_hotdog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03756">
        <property type="entry name" value="AfsA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AfsA" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="AfsA" evidence="1">
        <location>
            <begin position="198"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="33859" checksum="8795ED33938CB629" modified="2017-10-25" version="1">MTIDTATIPTASHVHTISRHLAHRCAVSEVFVTSLHAARSDEFVVGAQLPRMHAFYGDHLAPWDGTYDPMLVMEAARQAAIALTHEYFGVPPDFGFVVRTFNGAVAESDSWVIGPAPADLVMSVQISRRHRRGEVLQGVDMVLDIECGGAPLMIVDGSFTWVSPSRWEALRDGLRTGLGLGDIGAALPPGQSAAAVDVGRANGRNVVIGPMRRVGAAAVAELAIDTGHPILFDHAVDHVPGSVLLEAARQTVVAMSASEPSRLIGVSSSFERFVELDHGAECVARASDAAPGQIDCEIHQCGAVAARIGLRYDTDEAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HED2</accession>
    <name>A0A231HED2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47095">
        <property type="protein sequence ID" value="OXR47095"/>
        <property type="gene ID" value="B7C42_00217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="727" mass="79324" checksum="28233D6F597EB5B2" modified="2017-10-25" version="1">MTTDTAPELTADSLVWQILFWPSPFREGAATSLLRHWAAQKHASQLILEARSTSDGVEYLVGSQLRHAQGVRRSVEQLVPGSVVTPFDTEERGDIATARRLKLTATDWPLEPVDRIASSRSILSALTAVKGTERLAIQVILGPRRQPMLPPAMGPTGGHQSTASKVWNGLLPDRRPNARQALVRKLGQHGFAAVIRIGVEAGTAERRKSLLLGLAAAIGTVETAGVHFKLADEKAGKINEPKATWSMLAPSQPLSVPELSHLLAWPVSDHDERFPGQPPLHPKPVRPTPPLLTGERVIAEANAPGVSGTLSYDVLDSMRHTWVIGPNGTGKSTLLLNLIVQDLKAGRPVVVIEPKDLVSDILARIPAERAGDIVLLDPLDEAPVGINPLAHSEGRTPEVIADSLFGTIHAIHGDLGPRSADILRNALEVLAKRDDASLTMLPLLLTNPGFRRSLTQRVIRDDPFAAGPFWAWFDSLSPEALDTKIAPLSNKLRPLLTKQLRAVLAQRNPKFNIRDVLRRNKALLVPLQKGVIGPEAAQLLGAIILAELWQAIRERAGTPEDSRTAVMVYIDEVQDYLRLPTDLGDALATARSLRAGFHLAHQYQKQLPPAMLDAFRNNARSRITFQLQAGDAKDMATGQSVLAPEDFGALPAHHVYASLMRDNTVQPWASGVTLPPPPETSDRNEIRRISRERYGQPLDEIEAGFAELLDQVNGEADGAPRRRRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEU1</accession>
    <name>A0A231HEU1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47328">
        <property type="protein sequence ID" value="OXR47328"/>
        <property type="gene ID" value="B7C42_00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009317">
        <property type="entry name" value="ChaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037205">
        <property type="entry name" value="ChaB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06150">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140376">
        <property type="entry name" value="SSF140376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho_N" evidence="2">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="15629" checksum="08101F1066A59C46" modified="2017-10-25" version="1">MPKTTRRGDPKPSELPSTIRKSDEHAQRIFAEVHDSALEEYQSEQRAHRVAYAALKHSYEKVGDHWEPKKQKGPSDERARHGGPEPAGKTAAGVDANASKQHLLDIAKRLDISGRSRMTKKELIESIERSNERARRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEV8</accession>
    <name>A0A231HEV8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Streptothricin hydrolase</fullName>
            <ecNumber evidence="2">3.5.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sttH</name>
        <name evidence="2" type="ORF">B7C42_00329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.19" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47207">
        <property type="protein sequence ID" value="OXR47207"/>
        <property type="gene ID" value="B7C42_00329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="20868" checksum="EF77FFE2DC10CABC" modified="2017-10-25" version="1">MSAVATPLRRVVGLDDELPRLADATVVMIDFQNTYREGVMRLPEADGALAAGARLLAAARALHRPVVHIVNDGGPGTPYDVGSDIGAIIAEVAPAEGEPVVVKNFPDAFHETDLHDLLRRTTAGPDLVLAGFMTHMCVAFTAQGAFNRGYHPTVVAEACATRALAAPGGTPLSANAVHAAALTTISDLFGRIAPTVASLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEY0</accession>
    <name>A0A231HEY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47531">
        <property type="protein sequence ID" value="OXR47531"/>
        <property type="gene ID" value="B7C42_00656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="41624" checksum="B7C315C1933AF1AD" modified="2017-10-25" version="1">MTGHGVGVDGDSGGGVASLVTVDADERRLAWVYLSRVVEGPCPALSALIARVGVVEAARAVRECDLPESLRGPTERRRDVDRAERDLELMARIGGRVITPDDPEWPQWRLLGLTQLDPARDADAAVPLVLWARGPLSLQQYTEQALAVVGARCSSGYGEQVTAELAGELSAHGWTIVSGAAFGIDGMAHRAALAAGGPTIAVLACGVDRPYPAQHERLLAEIAETGVVVSEYPPGAAALKHRFLARNRLIAALSDGVLVVEAGMRSGARNTAKWARRLGRPALAVPGPITAAASVGCHRMIRDREAILVTRVDEIHDEVGPLRLSLPTGGEAGAHLAGDQATVFAELPVSGSRLPKQIADESGLTIHAVRAALVALEVAGLVGSDSSGWFRTVRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEY2</accession>
    <name>A0A231HEY2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsA_1</name>
        <name evidence="3" type="ORF">B7C42_00648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47523">
        <property type="protein sequence ID" value="OXR47523"/>
        <property type="gene ID" value="B7C42_00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="680"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="840" mass="89725" checksum="379942B72E09E019" modified="2017-10-25" version="1">MSASVTTASEPVSTEATTGTEASVGTAPADAPATGKVRLASVGRRIAEELSVRDEQVRAAVELLDGGSTVPFIARYRKEVTGGLDDAQLRQLEERLHYLRELDERRNSILESIRGQGKLDAALEQQIMLAETKARLEDIYLPYKPKRRTKAQIAREAGHEPVADALIGDPATDPAAYTAEQLDGARAILVERFAEDADLVGELRELMWERGQVTSRVRTGKEEAGAKFADYFEFSEPFAKLPSHRILALLRGEKEDVLSLSLEPDTEEPEPGQRTIYEGRIAHKFGIADQGRPADTWLLDTVRWAWRTKLQVSLGIDIRMRLRQSAEKDAVDIFAANLRDLLLAAPAGTRTTMGLDPGYRTGVKVAVVDGTGKVVATETIYPHKPQGQTEKSLAVLGALVARFDVELIAIGNGTASRETDALAAELISRIGATPGARKPTKIVVSEAGASVYSASAYASQELPELDVSLRGAVSIARRLQDPLAELVKIEPKSIGVGQYQHDVSETLLARSLGAVVEDAVNAVGVDVNTASVPLLSRVSGIASSVAESIVAHRDQNGPFRSRTALLGVPRLGPKAFEQCAGFLRIRGGDDPLDSSAVHPEAYPVVRRMLEATGRDVPGLIGNTSALRALRPSEFTDEKFGVPTVTDIIAELEKPGRDPRPEFKTAEFAAGVEKVADLEPGMVLEGVVTNVAAFGAFVDVGVHQDGLVHVSAMSHSFVRDPREIVKSGDVVKVKVLEVDVARQRIGLSLRLDDEPGAGKPEKGGAGQRGGQNRGGQPRGGQGNQGRGGQGRGGQDRGGQDRGGQNGGGGQNKGQGRNQQRRSAPEPSGAMADALRRAGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFD4</accession>
    <name>A0A231HFD4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47592">
        <property type="protein sequence ID" value="OXR47592"/>
        <property type="gene ID" value="B7C42_00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="9558" checksum="A4A28731B07E2C9A" modified="2017-10-25" version="1">MTGDEELIQVEQVIERLIAGHPRVPPEDIELIVRGIHKRFSDARVHDFVPLLVEKAARQAISIRPSGTAAPSPRIRPRGTHPVTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFQ9</accession>
    <name>A0A231HFQ9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47556">
        <property type="protein sequence ID" value="OXR47556"/>
        <property type="gene ID" value="B7C42_00681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14606">
        <property type="entry name" value="Lipase_GDSL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="144"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="35825" checksum="E0371EF9264BB87F" modified="2017-10-25" version="1">MTDDLVNWDGVVAVSDAGQWRQPWRLPPDRLAAAFSPELAEHAAVATGVRLGLVTDAAEVTLPVHSTPIWQPRPRFVDVFVDGRLTQRVPVGSGAEDVVVALPGTRSRVELWLPHRGAVTRVGAPSVPAGATVEPWESDGPRWITYGSSLTQCLITEAPSDTWPARIARTHGWRMLNLGFAAQAYLDPFVARAIAARPADLISVELGPNLYIRGPFTARSLGGLAAGFLETIRAAHPDVPVVAFSPPVWVQRENEPNPHGLTLRDVRALVEDVVAVLQRLGDDNLHLVSGAELFGAGDAALTVDGLHPDAAGDALIAERFGPRLAAALATTAPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSS6</accession>
    <name>A0A231GSS6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000113">
        <property type="protein sequence ID" value="OXR39638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39638">
        <property type="protein sequence ID" value="OXR39638"/>
        <property type="gene ID" value="B7C42_08294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="32133" checksum="0ABA1BDBA1F3118C" modified="2017-10-25" version="1">MPPGAGDTPRIESDQVVAAQHIRFEHITDEVERVEPRRTRPARVGQQHTATVGCVARRDPRDRDGDARPLRVGVIEWHLDIRADRALRHQGRIRTRTPVEMLPQEARRRIHRSGDRDTGSRGHGHRESGNDHRCDSPADITQQTTRTTTLRGRAYAPLSNTHEDLTLQHVETESHGSHRQPRSGAAIAPEEPRTQANSGSHDVARPGPGFRGSGLAQASVASDHRGRPERRAGLPDIRKARIVTGGQRLVSALPAFQSAHEMFQSPSPSTPDRVSPTVFLTIAISPRLAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT33</accession>
    <name>A0A231GT33_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000066">
        <property type="protein sequence ID" value="OXR39783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39783">
        <property type="protein sequence ID" value="OXR39783"/>
        <property type="gene ID" value="B7C42_08148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="447" mass="48780" checksum="B9825810E6F62057" modified="2017-10-25" version="1">MIVSTWTGAEVRALRTVALRLTQEQFAERLGFQPPTIRKWERATHERPVRGDSAAALDVELARLTDEQRDRFASVTGKVARPVARDPRTPPRTTDNLGEHDELNTYGIEDEVKRREFGMFMGAAALTAAANAPCISHTVGVSDARQLAERVTELARREQTIGGAGLVMTGLRDLAIAKQLLETGTFSDRAASLFMSAAGELATITGWMAYDADIHPLARQCYADAFALANQAGDDDLTIHVCLNAAHQSIALSRTGESNPHRALGHLERARQLTHGRPPGRIHALIAIREALAHAILYDRTAFDRAVATAWRELDAAISYEPLSECPRWLRFVNASEIRSQEARGLGDLGQSRKALALLVADDDTDEAGTRNRANYRAGLAATLGKTRDINSAVTEGLSVLAELESAVSSTRTLRLLAPVRALADNLPDDEFARRYDNLQHQAIGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT74</accession>
    <name>A0A231GT74_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39819">
        <property type="protein sequence ID" value="OXR39819"/>
        <property type="gene ID" value="B7C42_08107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="35531" checksum="F66533C0CDA7E68C" modified="2017-10-25" version="1">MSNDEITISVDVRFAMVPLWVTQCELITDRALRLYIVLRQHADNATGTSWCKRKTLAAECRCSVKTLDRALRELVAAGAVTVRARWKSAGPNPSYSFEQSATHPEQTSSLYTVRSLPPAAPARGGDKFVPTPNADPEGGGDRFVPRGGDRFVPGVGTDLTPKLDPPELDPEEPEEGGCVSGVPHLPADSPVDNPTPQANPIEANEPPPPWCPDHPGNPGDVKCGQCKERRLERKAWEERAARARAAAEREQVASRMRADAATITACGMCDEDGFIEPALKCLHDPAAIETAREGSAKVRAALASRPRRYRNSPLINHHHRTREHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU39</accession>
    <name>A0A231GU39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40065">
        <property type="protein sequence ID" value="OXR40065"/>
        <property type="gene ID" value="B7C42_07869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="28466" checksum="37B9460EF5B38B52" modified="2017-10-25" version="1">MIMTDHPAWLQTEAGAAYRAVAVGDSAVLIKADSAEGTQVVDSGGSTLRVDTVDPSVLSGPDDLVAPLKDAGIVVRVANPSLWNAVTAAIMRQVVQAGHARTRYLRFCTAYGEPVTRDGLTAWLFPEPHPILALTDEQFGSVGAAFPKSALRDAARGFLTHGEVWETLSAIDLVQALQTIPRVGRWTACTAVADYTNDFSFYDYSDIAVQPAARRLNPERDWPQGAPAFKAAWEEMAGNQLSAWTILTLTWGINHGKLDRSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU63</accession>
    <name>A0A231GU63_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40118">
        <property type="protein sequence ID" value="OXR40118"/>
        <property type="gene ID" value="B7C42_07826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="28049" checksum="533016495E981CAF" modified="2017-10-25" version="1">MAGDLRCAAEPVVRQRRSLDAWQLRRGADRLPAARRTARLDRRHQCLRAGRSVPLRRPRGARVVARGSGRGAGREGIRPLRRARCPDLAIPADGAVGRCGGELAVGAVSRVRRRGDPAPQLPVDDCLRPPSRGASGRKRLVEHRIPVRRLARSRRTGRAPLGGEDRPSPGGAGVLLQGDLGTRRNRTRPRNDRGRTAFRCPGAARTRRIPARVRHRFWPRRRRHRHRLCPGHHVRHSGTGAGADGGGTAGNRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU79</accession>
    <name>A0A231GU79_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Catabolite control protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccpA</name>
        <name evidence="5" type="ORF">B7C42_07806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778638.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40142">
        <property type="protein sequence ID" value="OXR40142"/>
        <property type="gene ID" value="B7C42_07806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="34476" checksum="9E9C7E99E5864C0E" modified="2017-10-25" version="1">MPAAKQRVTASDVARSLGLSRATVGFVLNNTPGQTIPEKTRRRVLEEAERLGYRPNRAAQTLRRGSSHLVLLVLPDWPIEDSVADYLDELAVALDDAGYSLITYTRRSADRSRPLWETVTPDIVIGVADFDAAEQDSLRASGVRQIVTGTVAASEAAVAGVALQIEHLHALGHRRLAYAAARDDRLADLVQARIAEARAVAARLGLEPLAVAEVRPGDSSAVEQVQRWRDDGITGVVAYNDTVAAIVVGAALRAGIGVPAPLAVIGHDDTRLAEAFVPSLSSVRMDAAAMARYTAAVALHAAGRIPAAPEPVLPTMTVRRRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUB2</accession>
    <name>A0A231GUB2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="2">2.7.7.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498542.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40213">
        <property type="protein sequence ID" value="OXR40213"/>
        <property type="gene ID" value="B7C42_07728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23099" checksum="0E754814310D5A78" modified="2017-10-25" version="1">MSTVYDCSDPDSRAAGLTAARTTLKSGRLAVIPTDTVYGIAADAFDSTAVAGLLAAKRRGRDMPVPVLVGSWNTIDGLVFSVQPQARDLIRAFWPGGLSLVVQQAPSLAWDLGDARGTVMLRMPLHPIALELLREVGPMAVSSANVSGQPPATTVTEARHQLGNQVGVYLDGGPAEHGVPSTIVDLTGDRPRVLRAGAVTVAQVAEVLGMAPDELSPETTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUC3</accession>
    <name>A0A231GUC3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">atpC</name>
        <name evidence="10" type="ORF">B7C42_07738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498593.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40223">
        <property type="protein sequence ID" value="OXR40223"/>
        <property type="gene ID" value="B7C42_07738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="12904" checksum="2486FD140B797A64" modified="2017-10-25" version="1">MADMSVDLVAIERRLWSGTASFVSAQTTEGQIGILHGHEPVLGQLVEGGIVTIDSTEGERIVAAVHGGFFSCTGEAVRILAESAEFAGDIDLDAARAVLADPNASEQEQNAATARIRAVEAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUI6</accession>
    <name>A0A231GUI6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40294">
        <property type="protein sequence ID" value="OXR40294"/>
        <property type="gene ID" value="B7C42_07632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="80" mass="8734" checksum="80DC10D5D0E3FC60" modified="2017-10-25" version="1">MSESTFKPLSRDETVAVLVEALGPYIASTRRALGIAHTMATVVGGEPLTLLNHAIADYRTHERLVRVTYRALRSSASAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV53</accession>
    <name>A0A231GV53_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40517">
        <property type="protein sequence ID" value="OXR40517"/>
        <property type="gene ID" value="B7C42_07456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="11560" checksum="1A5F05A8839B2FD7" modified="2017-10-25" version="1">MRLQFLGKGGSGAGGCPTLYATDRDSYLVQGWVTPETGTVEIPHLLLGFAEPDTYVGAPLTDTGRGTFTLSGRPVTEPDVVGQLTLADDETAIEVPKQERKFYGATAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV69</accession>
    <name>A0A231GV69_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40514">
        <property type="protein sequence ID" value="OXR40514"/>
        <property type="gene ID" value="B7C42_07453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="160" mass="17202" checksum="BC6833B904A90C57" modified="2017-10-25" version="1">MSGGCSSTTDGTPTAPTTQDKQAATAALWDPCTIPHETWQQVGVAPSTLRPTIAGSDHVDGFKHCGGHDVPWTFGVDVWSQIYSVDDYRHKESGTTFTPVTIAGRDGFEYHKTADECNLIFASEKGSYSIEVLKQDPESAVVPCDQATTVANAIVPLFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV96</accession>
    <name>A0A231GV96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40526">
        <property type="protein sequence ID" value="OXR40526"/>
        <property type="gene ID" value="B7C42_07465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="39293" checksum="78D534CD337BD7CF" modified="2017-10-25" version="1">MTPTDTSVADTDTAFYTPPELDQHHRPGHILRLRPAPNLTGAGQSWQLLYSSCDSDGQLIAVSGTVMAPASAGDLGGSVLVYQPSFHGLGGTCAPSQLLVAGAEPDSAQIRAALARGFTVAVVDGEGLGVIGCGPHTFLAGRAAGQVMLDLGRAARRIPALKAAEAPIVLWGYGDGGRAAVSAGILQPSYAPELDLRGIAAGAVVTDPGKILQSLNLGTWAGLGFAALIGLSRAHRHLPLRHVFTEETRRLLADAEASNRVELCERYRHPLGVWCERIDPWNDPIWRVVLAHELISPTPAPAAPLHLYHGDADAIVPITVGRSLFHDYRARGAHVDWHEYEADHFRTARVATTDVLARLAEDLTHPTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVF3</accession>
    <name>A0A231GVF3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDE_Tnp_Tn3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_07279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40594">
        <property type="protein sequence ID" value="OXR40594"/>
        <property type="gene ID" value="B7C42_07279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="6">
        <location>
            <begin position="63"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="467" mass="52904" checksum="A6C02A6298A7E542" modified="2017-10-25" version="1">MSKALNRLDRGLTEGTTGGVRLTRRRGEQWISVPKLEKQPEPENLEKIKAEVARRWGTLDLLDVLKDADFLTDFTAEFTSVASREVIDRDTLRKRLLLDLFALGTNMGIRAIVNTGEQEESEAALRHVRRHFITRDNLRRATTKLVNATFAARDPNWWGSGTSCASDSKKFGSWESNFMTQYHQRYGGYGVMIYWHVERRNVCIYSQLKSCSSSEVAAMIEGLLRHCTDAEIAANYVDTHGASVVGFAFTELLGFKLLPRMKNIGSIRLYRPDDAGVYGELGPVLTRPIRWDLIAQQYDQMVKYATALRLGTAESESILRRFTRGGPKHPTYQALEELGRAVRTIFACEYLASEELRREINSGLQVVENWNSANAVVFYGKDSQLTGADREHAEVSMLALHLLQSALVHVNTLLLQAVLEDPEFHDLVGDTERRALSPLFWSNINPYGRFRLDMNTRLDLSRERVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVK0</accession>
    <name>A0A231GVK0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="9">PEP carboxykinase</shortName>
            <shortName evidence="9">PEPCK</shortName>
            <ecNumber evidence="9">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="9">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pckG_2</name>
        <name evidence="9" type="synonym">pckG</name>
        <name evidence="12" type="ORF">B7C42_07225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782634.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40667">
        <property type="protein sequence ID" value="OXR40667"/>
        <property type="gene ID" value="B7C42_07225"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="11">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="10">
        <location>
            <begin position="245"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="272"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="515"/>
            <end position="518"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR40667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="611" mass="66467" checksum="28E5D68EAC187CAD" modified="2017-10-25" version="1">MSDSSRVIARLDEVPVAHESVLAWIAEVAELTAPEHIVLCDGSRAEWDRLTARLVEKGTFVPLTGKPNSFWCVSDPEDVARVEDRTFICSERETDAGPTNNWVDPVDMRTVMTEHYRGAMAGRTMYVIAFCMGPLDAEDPKFGVQITDSEYVAVSMQIMTRSGDAVWEKLTAGTDFVKCLHSVGAPLGAGEPDAAWPCDTTKYISHFPERREIWSYGSGYGGNALLGKKCFALRIASVLGRDEGWLAEHMLILKLTSPQGKTHYVAAAFPSSCGKTNLAMLEPALDGWTAETVGDDIAWLRFGADGRLYAVNPEAGFFGVAPGTGATTNPNAIATIAKGNSIFTNTARTDDGDVWWEGLTTEPPAHLVDWHGNDWTPASELPAAHPNSRYCTPIRQCPSVAPEWDDPAGVPISAIFFGGRRATTVPLVAESFDWAHGVFTASVLSSETTAAAAGTVGVVRRDPMAMLPFLGYHVGDYFAHWLRLGAAADPVKLPKIFQVNWFRRGPEGEFLWPGFGDNVRVLKWALDRLDGTAEAVETPIGYVPAAEALDLTGLDDRQRARAAASLAVDIDEWVAEVPAIDHWYATIGGNRLPEPLREQLAALKLRLAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW13</accession>
    <name>A0A231GW13_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40755">
        <property type="protein sequence ID" value="OXR40755"/>
        <property type="gene ID" value="B7C42_07179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11420" checksum="89574D7855D46BAD" modified="2017-10-25" version="1">MSEVVNIRSSDQPVELVADYDSAVRTHEESEPEWAYHAFRTEPGTAARRLTPSGTDPPASNQGMPVAVSPTVLRPLASSRFACRKAGRSTPKHDHFTLCWLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWB6</accession>
    <name>A0A231GWB6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator MhqR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhqR_4</name>
        <name evidence="2" type="ORF">B7C42_07031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043743.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40896">
        <property type="protein sequence ID" value="OXR40896"/>
        <property type="gene ID" value="B7C42_07031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="15778" checksum="939E98106A9C1A0A" modified="2017-10-25" version="1">MAIGDPDPVTAFGALHRELSVLYGKVARSYGLTPQQLELLCLVHKSRPTFGELAAALGCDKTNVTGMVDRLERRELLAREQDPADRRITRAVLTGPGLALRDDIRATLERQLAARLPGTQRDRMIDAVATAAAALAQSRPDPETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWK5</accession>
    <name>A0A231GWK5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">suhB</name>
        <name evidence="6" type="ORF">B7C42_06934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40968">
        <property type="protein sequence ID" value="OXR40968"/>
        <property type="gene ID" value="B7C42_06934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31154" checksum="C86AE1C8632AFF73" modified="2017-10-25" version="1">METVPETNSPADIAEAPVLDPAEIAELRRVSVYLAETAAAHVRRRRPEVFGPGRGEDGSVRTKSTPTDPVTVVDTETERLIRSLLAEARPGETVLGEEGGGSLGAAGEIVWVVDPIDGTVNFVYGIPAYAVSVAAMRGGRSLAGAVVDVAGELTYSAGLGAGATVAGGDAEPIALRCNDIDSVRLALVATGFGYGAARRERQGELVARLLPRVRDIRRIGSAALDLCMVAAGRVDAHYEHGLNPWDWAAGALIAAEAGAVLRLPGADSTGAQGALTVAAAAGIADELAELFDRFGVTAPIPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWN2</accession>
    <name>A0A231GWN2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fadI_4</name>
        <name evidence="7" type="ORF">B7C42_06810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41040">
        <property type="protein sequence ID" value="OXR41040"/>
        <property type="gene ID" value="B7C42_06810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="10"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="290"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="430" mass="44797" checksum="29CCA6249C0600AF" modified="2017-10-25" version="1">MATKRSRRAVIVAGARTPFLRAFTDYTRMDTIDLGVLAVGGLLERTGLPKDQVQAMVWGGVILPSAAPNVAREIALDLGLDHGCEGYTVTRACASGLQAVTAAAAAIERGEYDIMVAGGSDSTSNAEVKLPQKMVHAAAPLALGKPKPRDYLSAVAQLAPFTDLLPRRPKIAERTTGEVMGESAEKMARIHGITREEQDVFAARSHHRAAAAIESGRFDREVLPVATADGKTVTRDGLVRANTSVEKLATLAPVFQRDGTVTAGNASPLTDGAAAVLLMSEEKARALGVEPLAAFRSWSFVSVDPSDQVLIGPAISMPRALDKAGLALSDVDLVDIHEAFAAQTLSVVSALGSDTWAKSRLDRDSAVGEVDPEILNVHGGSVSLGHPFGATGARMVTTMANELALTGKSTALLGICAAGGHGASAVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXK3</accession>
    <name>A0A231GXK3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036504798.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41329">
        <property type="protein sequence ID" value="OXR41329"/>
        <property type="gene ID" value="B7C42_06472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="30460" checksum="644D1F82BEC6B736" modified="2017-10-25" version="1">MSADEVARVFAIEDKVERLKAATEGVAAAQQTINELTRIRRAVIRELHAEGWTFARIGAAAGLSRARIHQVSTQGPVPEGLFFGHGPLTVLTPDLRAVTRATPLIGAPDAAAPHRLAELLRQLGFTVTVERFLPGRPVDLDREGLIVLGGPELSPSLRYLVSADPRLRRTLARAGRVRRAIEDRAARRIYRPGGTEPFDIAYLARLPRPDGHGTILVIDGLHPPGSLGAIRLLGTRLATLHERADTRAFSAVIGVRYDRHTGEPIEVDLLTPIYRHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY65</accession>
    <name>A0A231GY65_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41539">
        <property type="protein sequence ID" value="OXR41539"/>
        <property type="gene ID" value="B7C42_06431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059346" evidence="1">
        <location>
            <begin position="24"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="31720" checksum="2938DEB3FB6E2CE0" modified="2017-10-25" version="1">MLRVASIVVALAFSTAFPTLIAAAPQAGAVAGTRCGTPLSPAEIRTVADLSDTTTIGAGSTLGRFDEAVARNHRITEILTSHHDWRGLFDVGLDAVEQDPVLPLQHDPTAFVDPEYAHAISYELLRRFLVNLHAEFTDGTPEPHWAWYFQLAGQCGQSPARVAMAGYNAHLTVDLAYAVAAVGSKPENAPDFFHIVDAIARGGDRIVDRTKQVYNADLGPLWRFYFVGEGLDRLFGQGVATGPLLQVADLGYNVVVWTNGLALQNPATAEATRAEINALWSADDAAFAVLARLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYG9</accession>
    <name>A0A231GYG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41625">
        <property type="protein sequence ID" value="OXR41625"/>
        <property type="gene ID" value="B7C42_06266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="11689" checksum="CAA206AF35D8F34D" modified="2017-10-25" version="1">MPATPPWVRRNRMVAWTSYFCVLIGFGTLAMGLTAAGSGHLGWALVAGAICAAAFVGGFSLFGATAYHDRTTHHSGPSLLWDSSWPGATLEPSHAPRAAHHRLRLRRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYT2</accession>
    <name>A0A231GYT2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030515097.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41759">
        <property type="protein sequence ID" value="OXR41759"/>
        <property type="gene ID" value="B7C42_06101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="14272" checksum="D6DF188632FC375F" modified="2017-10-25" version="1">MTDTAQNSTDENLNWLVTRFTREVPGVSHAVLVSADGLLQATSPHLPSDRAEQLSAVTAGLASLSAGAAQLFNGGKVMQSIVDMQRGYLLVMSVGNGSHLAVLANKQHDIGRIGYEMALLVDRVGSVVQATARSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYV3</accession>
    <name>A0A231GYV3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycogen synthase</fullName>
            <ecNumber evidence="6">2.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41793">
        <property type="protein sequence ID" value="OXR41793"/>
        <property type="gene ID" value="B7C42_06135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="75"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="232"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="428" mass="45958" checksum="65E4B19997FB0450" modified="2017-10-25" version="1">MSSNPSGSDSSGPSGSSPVEYDDSLHYPESAYSASLEDASLADSESLIYRLHESGAPLHIVMVAPPYFEVPPAGYGGVEAVVAQLADALVARGHKVTLLGAGRSGTTARFIRVWDDILADRLGDPFPEVLNALKVRRIITELARTERIDVVHDHTFAGPLNAPMYTALGIPTVVTVHGPVDGEAQEYYTSLTDTAQFVAISDRQRSLAENLNWVGRVYNTVRPAEWPFQTRKQDFGLFLGRYAPYKGPDLALHAAHEAGIPLVLAAKMNEPPEKAYFENAVRPLLRDTDFVFGEADQIAKRLLLASARCLLFPIRWEEPFGIVMIEAMACGTPVVALRGGAVEEVVDHGVTGIICDDPAELPAAIAAADEIDPAACRRRVVERFSVDQLGAGYESAYYAAIDKLAGVPVPVASDGVPLIRPLSAVGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZN6</accession>
    <name>A0A231GZN6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.174</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">paaJ_4</name>
        <name evidence="6" type="ORF">B7C42_05686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782819.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42087">
        <property type="protein sequence ID" value="OXR42087"/>
        <property type="gene ID" value="B7C42_05686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="271"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="41006" checksum="E39EA2AFEA06D138" modified="2017-10-25" version="1">MTEAFLYTAVRTPFGRFNGALGGTRPDDLAATVIHATLAKTPALDPAALDEVVWGNANGAGEDNRNVARMAALLAGVPVSVPATTVNRLCGSGLDAAMIGSRQIETGDAALVLTGGVESMTRAPWVLPKPGRAFPAGDATLVSTTLGWRLVNPRMPAEWTVSLGEANEQLAQRFSISRERQDAFAVRSHTLAAAAWDDGFYDDLVVPVEGAELLRDEGVRTDATVEKVAGLKPSFRPEGTITAGNASPLSDGASAVLLGSSAAADLVGAAPVARIAGRGAHAVEPQAFGYAPVEAANRALARAGIGWDRVGAVELNEAFAVQSLACVDAWNIDPEIVNTRGGAIAIGHPLGASGGRILATLSKVLRERRERWGVAAICIGVGQGLAVVLENLETTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZW9</accession>
    <name>A0A231GZW9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase YtbE</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ytbE</name>
        <name evidence="5" type="ORF">B7C42_05756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42157">
        <property type="protein sequence ID" value="OXR42157"/>
        <property type="gene ID" value="B7C42_05756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="31168" checksum="7458BAEEDE9D247F" modified="2017-10-25" version="1">MVVNETYTLSNGVQAPKLGLGTWFIDDDKAARAVADAVEIGYRNIDTAQAYGNERGVGEGVRTCGVARDDLFVSSKLAAEIKNYADAAAAIDGSLDTMGLDYIDLMLIHSPQPWADFRGGDYAEGNREAWRALEDAYRAGKLRSIGVSNFEQRDLDNILSACTVAPQVNQLLVHVGNTPAELIAYCENTDILVEAYSPIAHGEILKNQDLAAMAARYGVTVPQLCIRYTLQLGTLPLPKTANPDHMRSNAQVDFVISDDDMHLLRNMEQFQDYGDSGKFPVFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0V4</accession>
    <name>A0A231H0V4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42468">
        <property type="protein sequence ID" value="OXR42468"/>
        <property type="gene ID" value="B7C42_05244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="16800" checksum="E1767FA45BEB9616" modified="2017-10-25" version="1">MKAVIVCVSVSHGNTRRIADALGEVLGARVVGPDELDPADLASCDLVGFGSGIFTMNFHPRLRELIRTLPAQSGTKAFVYATSGMPETPLRRYTRSLATLLTDRGFTVVDTFTCRGLDTWLPMRIVGGVSKGHPDAADLHAARTFAEGLRARITAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1G7</accession>
    <name>A0A231H1G7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgB</name>
        <name evidence="12" type="ORF">B7C42_05022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042085.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42686">
        <property type="protein sequence ID" value="OXR42686"/>
        <property type="gene ID" value="B7C42_05022"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="246"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR42686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="728" mass="81014" checksum="BE54F60667939A94" modified="2017-10-25" version="1">MNRRDLMLLAAGTHTDPHTVLGAHPHPDGTVIRTLRPHADSVSARIGGVDHPLHHIGHGVFEGVVGFPDLWDYRLVVAYPGSRTVLTADGYRFLPTVGELDLHLLGEGRHRRLWEVLGAHPRRYTTLDGEVTGTSFAVWAPNARGVTVFGDFDSWSGTSTPMRRLGSSGVWEVFVPGVAAGTRYKYRVHGADGRTVDHADPLAFAAETPPATASVVTDTAYRWSDQDWCAARARRDPTREPMSIYEVHLGSWRPGLDYRSAAEQLAEYVRAQGFTHVELLPVAEHPFGGSWGYQVTSYYAPTARFGSPDDFRAFVDHLHAHGIGVVLDWVPGHFPRDEWALARFDGTALYEHPDPRRGEQLEWGTYIFDYGRNEVRNFLVANARFWLEEFHIDGLRVDAVASMLYLDYSRPPGGWEPNVHGGRENLEAVDFLRELNAAVHTDHPGVVTIAEESTTWPGVTRSTEVGGLGFTLKWNMGWMHDTLGYLGRDQVHRSWHHNEITFSAVYAWSENYLLPISHDEVVHGKGTLWTRMPGDDYTKACGVRAVLAYMWAHPGKQLLFMGQEFGQFREWSHDRGLDWDELANPLHDGIRALVADLNVVYRAHPALWTQDTAPGGYAWIEADDRVHNVLAFLRYGTDGSVVACVFNFSGLEHRDYRIGLPAPGIWREILNTDATPYGGSGTGNLGAVSASACPSHGRPYSAQVTIAPNSALWLTPDHHRSIGNGRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1L4</accession>
    <name>A0A231H1L4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776864.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42732">
        <property type="protein sequence ID" value="OXR42732"/>
        <property type="gene ID" value="B7C42_05069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="18063" checksum="5982816EB27A1AC5" modified="2017-10-25" version="1">MNIDIPEGKDPIGYVWGEMVPGIGPAASKLSLAVYSHSTLGLREFEAARLRIAQINGCLFCQDWRTERDGQKVEVGFDQAVTEWRTTDSFDDRTRLAAEYAERYVLDHHNLDDEFWTRMRAHYSQAEIVELSMCIGSWLAFGRLNRVLGLDTVCVLPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1P7</accession>
    <name>A0A231H1P7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_18</name>
        <name evidence="3" type="ORF">B7C42_05108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42770">
        <property type="protein sequence ID" value="OXR42770"/>
        <property type="gene ID" value="B7C42_05108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="420"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="514" mass="54640" checksum="9B0DAED024C9B117" modified="2017-10-25" version="1">MYLTQGLHRAVQQNPDGVMSICGDRTRTFAEGADRVARLAAALRQLGVGAGDRVAILALNSDRYLEYVLAVPWAGATLNPVNIRWSPAEIAYSLEDSETAVLLVDDVFAAMVPALRAAAPVLATVIHCGDGPAPDGMLSYEELIAGADPVEDARRGGDAPAGIFYTGGTTGHPKGVVLSHAGLQISGLGSLSTGYLAQPGARYLHAAPMFHLADLAGCVTQIMMGGAQVMVPAFDPVAVMTAIADHQVTDTLLVPVMIQLIVDHPRVSEFDLSSVRGIVYGASPIAQAVLERAMRAFPQARFAQAYGMTELSPVATLLGPDDHLAGRLRSAGRAAPHAEVRIADAEDNEVPRGTVGEILVRGGHVMLGYWNRPEETAAALRGGWMHTGDGGYMDDEGYVYIVDRMKDMIVSGGENVYSAEVENAVSAHPSVAACAVIGVPDEEWGERVHAVIVCHTGATVTVEEIRDHAKRLIAGYKAPRTIELVDALPVSGAGKILKRELRKQYWGEAERQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H246</accession>
    <name>A0A231H246_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panE</name>
        <name evidence="5" type="ORF">B7C42_04805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42919">
        <property type="protein sequence ID" value="OXR42919"/>
        <property type="gene ID" value="B7C42_04805"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="177"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="37081" checksum="E786AC5AA720EC0C" modified="2017-10-25" version="1">MTFRVTVLGAGSIGLFVGGKLAAAGAEVSFVGRPRLLDEIGAHGLRLTDLDGGDDRVAASGFRTETEPDSAATADLVLVTVKSAQTAQAAAQLRNRVRADTVVVSLQNGIGNDAAIREVLPTAVVSAGMVMFNVVHSGPGHFHRGTDGTVAVAGDPALSRFAPLFERAGLPLDRHQDLRPVQWAKLLLNLNNAINALSGRPLREELAARDYRRCLALAQDEALAAMRRARIRPARLTVLPPRVMARLLTVPDAVFERVAGRVLAVDPMARSSMADDLALGRRTEIDWLCGEIVELGRMVAVPTPVNARLVELIRAAENGDERRWTGPDLLAELRGAVAREATRPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H252</accession>
    <name>A0A231H252_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative helicase HelY</fullName>
            <ecNumber evidence="4">3.6.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">helY_1</name>
        <name evidence="4" type="ORF">B7C42_04802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42916">
        <property type="protein sequence ID" value="OXR42916"/>
        <property type="gene ID" value="B7C42_04802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="rRNA_proc-arch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="rRNA_proc-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="260"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="896" mass="98685" checksum="288138617AFA0B6D" modified="2017-10-25" version="1">MGQPSLTGELAAFAADLKFSLDPFQQQSCAALENGHSVLVCAPTGAGKTVVGEFAVHLARAAGGKCFYTTPIKALSNQKYSDLVERYGRDAVGLLTGDQSINPDAQVVVMTTEVLRNMLYAGSDALHALSFVVMDEVHYLADRFRGAVWEEVILHLPPEVRLVSLSATVSNAEEFGAWMETVRGDTAVIVDETRPVPLWQHVMVGRRLFDLFDTKSSDQKILVDEDLVRYIKHREAADRMNGWSGPRHRGGPRRDFRPLPRPEMLARLDEEGLLPAITFIFSRAGCDGALAQCLRSRLDLSRPDDAAEIEAVIERHTGDLPRADLDVLGYWEWREALFRGLAAHHAGMLPAFRHTVEELFVRGLVRAVFATETLALGINMPARTVVLERLVKFNGETHAELTPGEYTQLTGRAGRRGIDIEGHAVVMWHPDVDTSAVAGLASTRTYPLRSSFRPGYNMSINLIDRMGAAQSRELLERSFAQFQADRSVVGLVRGIERNEAQVRKLRSQIGDDGFLEYLSLRERIKQRERELERQGRADRRGASVESLTSLRRGDVVAIPTGRRQGLAVILEPDASPGDPRPLVLTADTWAGRVSAADFPTPAQPLGRMRLPRHVDHRTARARRDLASALRSTGIAVPGRGRRGGRARAADDRELATLRRALRAHPAHSRPDREQLARLGERYNRLERETESMRQKVAATTNSLARTFDRIVALLSERGYVDGGEVTPDGRRLARIYTEADLVVAECLRQGLWRGLGAAELAGVVSVLVFESRQEGGYLGPAGPTEPVRRAVGATIGVWSQLRTDEARHKLPPTREPDLGFVTGIYKWARGDGLAESLLASGDQGSALSAGDFVRWCRQVIDLLDQIHQTADDTEIAATAAKSVRAIRRGVVAVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2D5</accession>
    <name>A0A231H2D5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HTH-type transcriptional repressor KstR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kstR2_8</name>
        <name evidence="8" type="ORF">B7C42_04891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43005">
        <property type="protein sequence ID" value="OXR43005"/>
        <property type="gene ID" value="B7C42_04891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="7">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="30882" checksum="1550EEEB4A65B03E" modified="2017-10-25" version="1">MGSRVRQARTDAGLSLRATAERIGVSPATLSAIENDKTGVSIARLRALAAALDTTVAWLIDESPAPRPARPRPRPSGTPEGGTARAWREFPPLDIDPVLAAAIDSFVETGYHGATMRSIAHRAGMSVPGVYHHYRDKQELLVRALDLTMDELHWRTRAARGEAIDGRDRLIRVVEALALFHTHRRELAFIGASEMRSLTPDNRRRITASRNEIQYLLDADIGTALAEANLPAAHARVAGRAIATMCTSLPQWFRLDGPATPEQIATEYAGFALGLLGMETRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2K0</accession>
    <name>A0A231H2K0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43075">
        <property type="protein sequence ID" value="OXR43075"/>
        <property type="gene ID" value="B7C42_04961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280098" evidence="3">
        <location>
            <begin position="28"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="363" mass="35930" checksum="D60F19B88295F72A" modified="2017-10-25" version="1">MRPSPATVLGPVLALSALITVLVTAFAWPTSNLTPRHLPVGVAGPAPAVEQVRQGLGAVGESAIDTTTYPDRSAAVRAIEDRDIYGAIVFGANGPEVLTASAAGPAVAQALSEAARSMSQRMQPPAPQTISGQSPQSSSPAAGQPAPTTPTPQQLSPTPVITDVVPTPAADPHGAVFGLTLVPMVIGGLLTGAALSLLTLGRATRIDAAVAVALIAGFAVTAVLQTWLDVLTGNYLANAGVVALAIGATALTLLGLRAAIGLAGIGVGAATFVALGIPLSGAMSAPELLPTGWGTLGTLLPPGAAATALRSTAYFGGSGSAAALAVLSCWTVGGLLLATLPRRTRHLPEQAHDAAPTQLAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H315</accession>
    <name>A0A231H315_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD</name>
        <name evidence="3" type="ORF">B7C42_04661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909036.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43239">
        <property type="protein sequence ID" value="OXR43239"/>
        <property type="gene ID" value="B7C42_04661"/>
    </dbReference>
    <dbReference type="GeneID" id="66723455"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="423"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="515" mass="56251" checksum="B97BCC0C6F2D3B99" modified="2017-10-25" version="1">MLVGDIPTNNARRYPDKAAVIESDCMRTWSQVDDRARRLANHLRAQGLVTGDRVLVIARNCAEWPEIVFAIAKAGLVVVPVNVRLAPDELAYLRDDCSARAAVIHTDQVERFGAELDDLDTVLEIGSAGASGHPDYETTLAQAAPTDPAPADLHPDAIVNILYTSGTTGRAKGVVNTHRNLLAQAIDTTLVTESNRSDVFLATTPFFTAGGSVRTLSWTYLGQTMVIHRKFDPQAVIDEIERSRVTFTTFIPTMLQRTLRILEEGPARDMSSLRRISYGSAPVPPGLARKAMDLLGCDLQQRYGLTECGGQATIFTPQDHRDMVAGKTSILTSCGQETPMCSIRIVDADGNELPAGEIGEIVIRSDANAIGYWNRPEQTAETFRPTGLWSGDLGYLDSERYLHITGRKTDMIISGGFNVYPAEIERVIGEHPGVELVAVVGVPDPEWGETPVAAVIARDGFDPDGLTAELQALCRSELAGYKQPRRFVYRSEFPLGPAGKILKRRIAEDLRVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H364</accession>
    <name>A0A231H364_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyl-CoA dehydrogenase fadE25</fullName>
            <ecNumber evidence="6">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43267">
        <property type="protein sequence ID" value="OXR43267"/>
        <property type="gene ID" value="B7C42_04689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="223"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="373" mass="40043" checksum="7F5E78B6667CCF04" modified="2017-10-25" version="1">MTLFATFTDEQNQLRALVRDYVREKSPETEVRRLMATDEGYDPVIWTQMARDLGLQGLAIPEQYGGQGAGWIELGIVLEETGRALLCAPFFSTVVLAATTLLESGDEEAKEQYLPAIADGSLIATVTLIVEHGCWNPDDVTVRATHDPDGWTLNGTQQYVLDGAHAQLIIVPARTATGISLFAIDTTDSAIVRTPSITLDQTRKLAVVELDSTPARLIGAEGGGRQVLERVLDFAAVALAAEQVGGAEAALDMSTAYLKTRVQFGQVIGAFQALKHMAADVLIEVESAKSAAYYALAAAAADNEELPAAAALARAYCSEAFVTAAHQNIQFHGGMGFTWEVPAHLYFKRARSSELLLGDAGTHRARLAQRIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3B1</accession>
    <name>A0A231H3B1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phenylacetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">styD_2</name>
        <name evidence="5" type="ORF">B7C42_04730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43308">
        <property type="protein sequence ID" value="OXR43308"/>
        <property type="gene ID" value="B7C42_04730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008957">
        <property type="term" value="F:phenylacetaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="28"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="487" mass="51353" checksum="F4D54FB2253CD29D" modified="2017-10-25" version="1">MTSQTIDTTRPAVHLRIGAERITSGSGGAHQHINPVDGRVDATIPLAGRAEVDLAARTAHEAFADWRRTRPSERRRLLLQLADLIEANADEFARLGAIDNGTPIPVAAGLVASSIEWTRYYAGWADKLTSEVTGSFGPDGEFSYSLGQPYGVIGVIITWNGPLISLAMKIPAALAAGNTVVVKPSELTPFTAELFADLVEQAGIPAGVVNILPGAPEAGAALVEHPLVKKVTFTGGPDTARKILHSCADLMKPSVLELGGKSANIVFADADLDQACSHGTMMSIGALSGQGCALPTRMLVQDSIYEEMIGRIKAFAEFITVGDPLAEGTVSGPVVNEAALHRILGMIERARADGARLVTGGHRIEGALADGFFLEPTVFADVDPQSELAQKEVFGPVLAITPFATEQEAIEIANNSEYGLSGYIQTNDLRRAHRVAEELITGEVLINGAMNLGVNRAFGGIGLSGLGKEGGRQGIEEFLRLKNIAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3F9</accession>
    <name>A0A231H3F9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cadmium-induced protein CadI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cadI</name>
        <name evidence="3" type="ORF">B7C42_04235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782667.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43368">
        <property type="protein sequence ID" value="OXR43368"/>
        <property type="gene ID" value="B7C42_04235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="170" mass="18008" checksum="038E333B56A7D909" modified="2017-10-25" version="1">MSRIQLALNVDDLDRAVAFYSTLFDTEPAKREPGYANFAVEQPPLKLVLLENTGAGGTINHLGVEVETSEQVHDEIARLSQAGLFTAEQIGTTCCFARQDKVWVTGPHGEKWEVYTVLADTETFGDAPEFADDTTAVQACCGTADAAGESARCATDAGRDALAGGATCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3N1</accession>
    <name>A0A231H3N1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43441">
        <property type="protein sequence ID" value="OXR43441"/>
        <property type="gene ID" value="B7C42_04308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="177"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="32390" checksum="3AFCB4F4B06AA050" modified="2017-10-25" version="1">MTTEESVTEKSAPAKSARTGQPETAKGPIVVAVDGSPTSLQAVAWAARDAALGGSSLQIVHSIAIPASFGPGLAAGTAQPDWLRTDGEQILTRATQVARDIGGPDLDIDAELGLELIIGDMLVRSETAGALVAGSRGRGALQRGLLGSVSSALVHHAKCPVVIVKSHSATDPVTAQRPVLVGVDGTENSEPAVDAAFAEAHRRGVELVALHSWSDTTGLDISMFGWDTIVRAEHAMLAERLTPWRERYPELPVTLQVVRDNPAKSLLEHSDSAQLVVVGSRGRGGFAGMLLGSTSAALIGSVECPIMVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3V1</accession>
    <name>A0A231H3V1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arsenical pump membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">arsB</name>
        <name evidence="11" type="ORF">B7C42_04415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43547">
        <property type="protein sequence ID" value="OXR43547"/>
        <property type="gene ID" value="B7C42_04415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="414" mass="43786" checksum="F32BDB0D0730AC3F" modified="2017-10-25" version="1">MSEPVAPERNARDPETEEASAPRVLDWIRIAVLAVGVLCVLTGWLPRADAEANMRRIGPLLLFLGSVIVLAHLARRAQVFDVIAHRIAIAGRGRYPALFVLCVGFASVTTMVLNLDTTAVLLTPVMLALARPARIPPLPLAMTTLWLANTASLLLPVSNLTNLLAADRIGLDATGFAARMWLPQLISLAATMAALWIWYWRRGRRGTDRYVAPPPIRLENARERALFATAGGACALFVLAIPFVGDHIGYAALAAAVLAIAGFAVFDRDALRPSLIPWQLLIFVIGLFLVIPTLGRYGLSDLMAALIGTDSGAAGAYRAAGAGLGLSNIVNNLPAYTAGEAVIPPEHRDQLLSLLIGTNVGAIATPWASLATLLCLEFCRSHAVRVPPVRFVCTGLALAVVATAGAVGGVLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3W2</accession>
    <name>A0A231H3W2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 39</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydaD_3</name>
        <name evidence="2" type="ORF">B7C42_04293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43426">
        <property type="protein sequence ID" value="OXR43426"/>
        <property type="gene ID" value="B7C42_04293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="29174" checksum="F391BE4CB11EF67B" modified="2017-10-25" version="1">MGFPEQQQQVPGVQQRMTPQPDCGEDSYRGSGKLTGKAAVITGADSGIGRAVAIAFAREGADVLISYLDEHEDAQQVVALVEQAGRKAVAVPGDLSDPEHCKAVIDRAATEFGRIDVLVSNAAYQMTHESLDEISGDEWDYTFKLNVGALFHLVKAAVPHMPAGGSIIGSSSVNSDMPSPTLAPYAATKAAIANFCASLAQLLGEKGIRVNSVAPGPIWTPLIPSTMPVEKVRNFGDDVPLGRAGQPAELAASYVLLASDDGSYISGARFAVTGGRPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Y7</accession>
    <name>A0A231H3Y7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43633">
        <property type="protein sequence ID" value="OXR43633"/>
        <property type="gene ID" value="B7C42_04501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="112" mass="11435" checksum="56E2E10312BBD0FC" modified="2017-10-25" version="1">MRSPPTQAARSPTIAAGYRANPAGPWRSGPPRTRHNFLMPTYAYRCRECTESFELTRPMSESGDPAVCPGGHRDTVKLLTTVALTGKAAGSGAPSAPPAPSGGGCCGGGCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H401</accession>
    <name>A0A231H401_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43466">
        <property type="protein sequence ID" value="OXR43466"/>
        <property type="gene ID" value="B7C42_04333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040611">
        <property type="entry name" value="TetR_C_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18556">
        <property type="entry name" value="TetR_C_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="206" mass="21741" checksum="8F36AC5AFDA74849" modified="2017-10-25" version="1">MGVATAPNFQSDMRRLLRERVIQTARGLVCTEGWGAVNMSRVAKEVGVSRPVLYKEIGTKQDLAEVVIANEVDVFLVGIAEQLAAHPDDVIAGLIAAVEFTLRSGADNMLLKAVLAGRSAPDTALLPALMTEPEPVLGRAIGAVTATVRAQYELASVGEEELASVAETVVRLALSHLFQPTGPVERALDQIRVVAVGLLEPLLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4L5</accession>
    <name>A0A231H4L5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator CdhR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdhR_8</name>
        <name evidence="2" type="ORF">B7C42_04122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781095.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43883">
        <property type="protein sequence ID" value="OXR43883"/>
        <property type="gene ID" value="B7C42_04122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="16416" checksum="7CACA8972AB4AE3C" modified="2017-10-25" version="1">MSSTPAPDQRLRDLARLRKVRDRIDREYAKPLDVEALARDVHMSAGHLSRQFRLAYGESPYGYLMTRRIERAMALLRRGDLSVTEVCFEVGCQSLGTFSTRFTELVGVPPSVYRREAADATLGMPSCVAKQVTRPIRNREAQVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5D5</accession>
    <name>A0A231H5D5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44109">
        <property type="protein sequence ID" value="OXR44109"/>
        <property type="gene ID" value="B7C42_03666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041098">
        <property type="entry name" value="Rv2175c_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18367">
        <property type="entry name" value="Rv2175c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rv2175c_C" evidence="1">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="13664" checksum="297A1BA9A6B0EB85" modified="2017-10-25" version="1">MQVSAFPCSDDVVPESVTLLPLPDVAEQLGIAVTRVHQMLRDHQLLAIRRDGIAGIPKDFFDSSGAVVKPLTGLITVMRDAKYTNEEILEWMYAEDDTLPGRPIDAIHGPLAREVVRRAAAEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Q4</accession>
    <name>A0A231H5Q4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">qcrB_2</name>
        <name evidence="10" type="ORF">B7C42_03648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777284.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44092">
        <property type="protein sequence ID" value="OXR44092"/>
        <property type="gene ID" value="B7C42_03648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="9"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="542" mass="60093" checksum="BA68537AEEF1B6CA" modified="2017-10-25" version="1">MSPSKVVAQANEMDERYRAAAFVKRSINKVFPTHWSFLLGEIALYAFIILILSGIYLTLFFDPSMSEVVYHGAYQPLRGVTMSRAYETALNISFEVRGGLFVRQVHHWAALLFACSIIIHLFRIFFTGAFRKPREANWVIGSLLLILAMFEGFFGYSLPDDLLSGTGLRAAFGGITMGIPLVGTWMHWLIFGGDFPGTIIIPRLYIAHVLLFPGIMLALIAAHVAIVWYQKHTQFPGPGRTENNVVGARIVPVFAADQGAFFMFTLGVLAVMGGVLQINPIWNLGPYNPSQVSAGSQPDFYMMWTDGMARLMPPWELYLGRYTVPAPFWVALIMGLVFAVLIAYPWIEKRLTGDTVNHNILQRPRDVPVRTAIGAMAIAFYLVLTLACVNDIIALKFDVSLNATTWFFRIALLVAPPIAYFLAYRLCLGLQRADRTVLEHGIETGVIKRLPHGEYIEVHQPLGPVDSHGHPIPLEYQGAPVPKKMNKLGWAGKPGSGSFLRADPPAEAEALTASEHEAEHKQLEVLATYQEQTSGSGGKHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5V1</accession>
    <name>A0A231H5V1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative endopeptidase</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777432.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44142">
        <property type="protein sequence ID" value="OXR44142"/>
        <property type="gene ID" value="B7C42_03701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011275663" evidence="3">
        <location>
            <begin position="38"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="76"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="191" mass="19150" checksum="C53925402AB323FB" modified="2017-10-25" version="1">MAPSSVRGSSRRRYTRYLLAAIAATVSVSIWAGPATAAPADTGSSSGSLDSGSSSGSGSGSASGSASGSAALPLPSPRASIALSVAGSQAGKPYEWGGTGPNAYDCSGLVQWAFRQVGILLPRTTWEQATAGSAVPFGAMMPGDVVIVNTDGSHEGIYAGGGMLLNAYGPGVPIGLTPLSEFDIYAIRRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H607</accession>
    <name>A0A231H607_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44260">
        <property type="protein sequence ID" value="OXR44260"/>
        <property type="gene ID" value="B7C42_03821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="305"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="446" mass="48542" checksum="E59276D02DCC74C7" modified="2017-10-25" version="1">MVEAGENRSDGVMDAEQLAQRYRTLVEHSPDGVVVHEDGVVVFANPAIVRLLAAPGVDEVVGHPVAQFVAHRDVPAMLERIDRLHQTGDASETAEMTLIRCDGQAVDVETVSVLTVWQNRLAYQVVIHDLTAQRRAEAAQRRAEHHFTAVVSQLEEGVVVIDREGRIESINPAAQRIFGQDGDNLIGRRIDSLPLALLDANAQPLAPSHHPVARTLATGETISRYVFGVDRPDGQRRWLSGSSRLLNPGAPDSPAVSSFNDVTEFRASRRQLEYQATHDPLTGLANRSLVLSRLATALGVDEQSPVSNVLFIDLDGFKAINDTLGHAIGDTVLQIVAQRLQRGLRTDDVVGRIGGDEFLVLLSGRTQPDDLDGLITRLRQTMAEPIIARGHRIHIEASIGVTALRPGDPRTPEAVLHDADLAMYRAKPATSESNALGRRPNNTHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6C5</accession>
    <name>A0A231H6C5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Geranyl diphosphate 2-C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.255</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.255" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777680.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44317">
        <property type="protein sequence ID" value="OXR44317"/>
        <property type="gene ID" value="B7C42_03878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="32018" checksum="350840B597A957A3" modified="2017-10-25" version="1">MTVLQPATDGVLHTSYQRAVAAYWNDNPNDDRVNTELGAVDGLYHHHYGIGEPDWSVLEGPEETRGERIVAELHRLETAQADLLLDYLGDIGPGDRLLDAGSGRGGTSFMAHERFGCRVDGVTISEYQVGFANDQARERGVDDLVRFHYRNMLDTGFEAASMRGIWTNETDMYVDLPDLFAEVARLLVPGGRYVCVTGCSNDVTGGRSAAVSWIDAHYGCMIHPRGEYFRALTANGLVPIAVTDLTSATIPYWELRTQCELATGVEEPFLTSYREGSFQYLVIAADKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6G2</accession>
    <name>A0A231H6G2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pstA1</name>
        <name evidence="9" type="ORF">B7C42_03403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497805.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44613">
        <property type="protein sequence ID" value="OXR44613"/>
        <property type="gene ID" value="B7C42_03403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="84"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="32249" checksum="A5BAAC7D94F9F293" modified="2017-10-25" version="1">MTTTLDKPIKAPTFRHVSLGRKVRNNVATSVMWLCFGIALVPLGWVLILVLNKGFHAIVSSGWWSKSQKGVLPDQFAGGVYHAIYGTIVQSAVAAVIAVPLGIMAAVYLVEYGRGWLAKTTTFMVDILAGVPSIVAALFVFALWIATFGFPQSAFAVSLALVLLMLPVVVRSTEEMLKLVPDELREASYALGIPKWKTILRIVVPTALPGMISGMLLAVARVMGETAPVLVLVGYSKSINTNIFNGNMASLPLMIYQELANPEAAGRMRVWGASLTLILIIALLYIGAAVVNKLLTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Q2</accession>
    <name>A0A231H6Q2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-2-oxovalerate aldolase</fullName>
            <shortName evidence="7">HOA</shortName>
            <ecNumber evidence="7">4.1.3.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-keto-pentanoic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-oxopentanoate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_03261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:36003"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17153"/>
            <dbReference type="ChEBI" id="CHEBI:73142"/>
            <dbReference type="EC" id="4.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22624"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:73143"/>
            <dbReference type="EC" id="4.1.3.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 4-hydroxy-2-oxovalerate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44472">
        <property type="protein sequence ID" value="OXR44472"/>
        <property type="gene ID" value="B7C42_03261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="37173" checksum="378F8F155E9873CA" modified="2017-10-25" version="1">MNYVLQPFSQELDVRVTDTSLRDGSHHKRHQFTATEVRDIVAAVDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELITIAAQTAKQAKIAVLMLPGVGVKEDIKISQDNGASIVRIATHCTEADVSIQHFGYARDLGMETVGFLMMSHSQPPEVLAKQARIMADAGCQCVYVVDSAGALVLDQVSDRIAAVATELGDDAQVGFHGHENLDLAVANSIYAVKAGAKQIDGSARRFGAGAGNTPVEAFVGVADKIGIKTGIDFFAIADAAEDVVRPAMPQECLLDRQALMMGYAGVYSSFLKHAERQAERYGVSAAEMLVRAGKRKLVGGQEDQLIDIALELQREQTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H738</accession>
    <name>A0A231H738_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777142.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44833">
        <property type="protein sequence ID" value="OXR44833"/>
        <property type="gene ID" value="B7C42_02787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="7297" checksum="03A2BA20C744A464" modified="2017-10-25" version="1">MSADLSMARWFKSSHSGGSQDCVEVAFLADGTVGVRDSKNPTGPALAFAPADWDAFTAAVEHGRLTDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H758</accession>
    <name>A0A231H758_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <shortName evidence="2">MSH acetyltransferase</shortName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mycothiol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mshD_4</name>
        <name evidence="2" type="synonym">mshD</name>
        <name evidence="4" type="ORF">B7C42_03400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol</text>
            <dbReference type="Rhea" id="RHEA:26172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16768"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="EC" id="2.3.1.189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. MshD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44610">
        <property type="protein sequence ID" value="OXR44610"/>
        <property type="gene ID" value="B7C42_03400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01698">
        <property type="entry name" value="MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017813">
        <property type="entry name" value="Mycothiol_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021524">
        <property type="entry name" value="MSH_acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03448">
        <property type="entry name" value="mycothiol_MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="273"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="305"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="34617" checksum="B4690965F1D118D8" modified="2017-10-25" version="1">MGVSVQVPDWTTELAPATAAKIVDLVERANAADAVAPISEQAVLSVTASGPAGHDSADAGTDAPVGRTRHLAVERDGELVAYANLVPAHGDHPAMAEAVVDPRVRGRGIGATLVAAALEAGGPGARIWAHGNLAPARAVAGRLGLTVARELWQMRRALTQAPDGDQATIELPELKVPADIVLRTYAGPADDAEILRVNNAAFDWHPEQGGWTEAEIAVRRAAPWFDPKGLFIAADPADPTHILGFHWTKVHEPDETSDAVGEVYVVAIDPAAQGRGLGRVLTLAGLHYLRDRGLGAVILYTEADNTAAVHTYTRLGFETAHIDAAYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H772</accession>
    <name>A0A231H772_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44774">
        <property type="protein sequence ID" value="OXR44774"/>
        <property type="gene ID" value="B7C42_02728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012737182" evidence="1">
        <location>
            <begin position="32"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="18036" checksum="5EDE341DF16C0730" modified="2017-10-25" version="1">MPRHPRASFTLPALAALTAAGLGFTAAPAEAESRRSAAHPATGCLWAGTTHPAGATVIAGGRGYTCGADGRGTPIWSAGATSDRPDTVANPGSAGDPAAHFSLGARQPGTAYNDYCVGNQLVEGTDDVYQVVRGHDGRLFWKAAEPVSAWRFDRGTVAPQPTWRGTGLCYEGNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7L0</accession>
    <name>A0A231H7L0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 107B1</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44839">
        <property type="protein sequence ID" value="OXR44839"/>
        <property type="gene ID" value="B7C42_02793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="45356" checksum="04A88A8AA9822247" modified="2017-10-25" version="1">MLNDTDAVRNSGRTSGHGSPARSAEPQIRLDSTDFAADPHRAYESMRRRGPLVPIELAPGVPATLVIGYQAALQILNDEARFPADPRRWEKNAPPDCPVTPMLGYRQNALRTAGAEHARYRRTITDALDTVNLHKVHGAVARAADALVNSFCERGTADLRMDYAFPLTFRVLSELMGFPEDAASAAYQGMAAMLDGVGAEEGQQRFIEALLAVVEQKRERPGDDLTSRLLTHPEGLDPMEMVNQAALLFSAGTEPTCNLILNTLLLLMADEEYGGNVLSGAMDTRDAIDEVLFADPPLANFCMTYPRQPQLIGDVWLPADQPVVVSLAACNTDPHIVGGDRRGNRSHLAWGVGPHSCPAQPLAQTIARQAIDLLLDALPDIRPEVPAQQLSWRTGQFHRALAALPVVFPACPPMRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7N2</accession>
    <name>A0A231H7N2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative low molecular weight protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ptpA</name>
        <name evidence="4" type="ORF">B7C42_02754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44800">
        <property type="protein sequence ID" value="OXR44800"/>
        <property type="gene ID" value="B7C42_02754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="17607" checksum="46393742E5447922" modified="2017-10-25" version="1">MTFICTGNICRSPMAEKIFAAHLERAGLADRVRVSSAGTTAWHVGSDADPRTTALLTRHGYPIGHVAAMIGPDHLDADLLIALDSNHDRELTRLRIPDTRRRLLRSFDPDADDHDVPDPYYGDDTDFELVREQIEAAVPALLAWVREQLGEPATTGPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7T1</accession>
    <name>A0A231H7T1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_4</name>
        <name evidence="4" type="ORF">B7C42_02804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44850">
        <property type="protein sequence ID" value="OXR44850"/>
        <property type="gene ID" value="B7C42_02804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="453" mass="49204" checksum="ACCF93A5FD3DAF47" modified="2017-10-25" version="1">MIRLNATGGDEGGYRYRRGMGSSARRRPLKIVTGVSGSPKIYDAAIDPRRSTLDDALGVAKLAEEHRFDALFAADLLSFGAQGAIGAQEPLIFLSALSAVTRHVGLIATVTTTFHHPYNLARLFGTLDHISNGRAAWNAVTSSLGEENYGAGDLPSPEERYARATEVLEVANALFDSWQPGALTPDGHGRAVLDAERVRPIDYAGRYFTVRGPLNIPPLPQRRPVQFQAGQSEGGVELGARFAEVVFTSLATLDDALTYTKKIRTRAAELGRADGLPYIFSSLHTTYGATEEEARRLVRERAEATDFAAGRHALADMLGGEIDLSELPLDRPIPDSLLPDVHAVNRRRGRVEIFTALARSGKTLRELIIAAKDTGHWAAAGTPEQLADAIQERYDAGVLDVIGLGGLDDPRNRDFLLEGLLPELRRRGIVGSDYVGETFRDNLELPPLPPRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H831</accession>
    <name>A0A231H831_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44950">
        <property type="protein sequence ID" value="OXR44950"/>
        <property type="gene ID" value="B7C42_02907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="24"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="295" mass="32041" checksum="57E36E6FD719BCA3" modified="2017-10-25" version="1">MTTTPLLTLNNGVRMPAIGLGVFQTPPDETAGAVEAALATGYRHIDTAAAYGNEREVGEAIRGSGVDRSEVFIETKIWISDFGYEATLHAFDKSAGKLGVDRIDLLILHQALPSRFDLTVDAYRALEQLLADGRVRAIGVSNFMREHLENLLKQTSVVPAVNQIEVHPYFRQPDVLAADAEYGILTQAWSPIGGITFYRDSGHTSTLDDPVITATAEAHGKTPAQVMLRWGLQQGRSVIPKSTRPQRIAENFDVFDFDLTGDELAAIDALDTGQRGGPDPADVTLETFGIDIPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H862</accession>
    <name>A0A231H862_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DapB_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44937">
        <property type="protein sequence ID" value="OXR44937"/>
        <property type="gene ID" value="B7C42_02894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="361" mass="39349" checksum="00B73EDAE56C2A2D" modified="2017-10-25" version="1">MSTSDTIRVFQVATGNLGTEMIGRIRNHPDLELVGLHCYTPDKIGRDAGEIVGLDPIGVTATGTVEEIIAARPDVLTFHGVFPDEDLYEKVLEAGINVVTTADWITGFHRDTNHAHPSGRKVSEVIQAACERGNATFYGTGMNPGLCQILGIVHTADVADIENVTVTESVDVSCHHSVDTWKAVGYGRPIDDPTLPDSLYQYTAVFADSVYLMADAFGLELDEVTFSYELGACTKDVDLGWYFMPKGSLGANYIKYQGMVDGVARVETHLEWQMTPHTDPSWEIKGCYITQVTGDPNIYSKHMIFPRKGFDLSNPENFASIGMTVTGLPALNAIRSVVAARPGIITSADLPLRSFAGRFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H863</accession>
    <name>A0A231H863_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigG_1</name>
        <name evidence="8" type="ORF">B7C42_02985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45028">
        <property type="protein sequence ID" value="OXR45028"/>
        <property type="gene ID" value="B7C42_02985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="148"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="37031" checksum="FDD7C43E0917E588" modified="2017-10-25" version="1">MTDDEGDAVTTGDLMAEARAGDGAAFRALTGPYRAELQVHCYRMLGSFQDAEDALQDTLLAAWQGIGAFQERSSLRTWLYRIATNRCLNARRAAGRRRAKEWDVPNVDPPEPSRLGEVVWLQPCPDTLLEQAPAGPEARYELRESVSLAFLTALQLLPPRQVAVLVLRDVLGFRATETARMLDTTLDSVNSALARARAALERRRPTGRSPAPGSADEEAIVARFAHAWESADVEALVRLLTDDVFVSMPPIPFEYVGREVAGRFCAEIFAAGRRFDLVPTRANGQPAFGAYLRGTDDSSHGTGLYVLSLTGERISALTRFESTVLPWFGLPRTLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H885</accession>
    <name>A0A231H885_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44957">
        <property type="protein sequence ID" value="OXR44957"/>
        <property type="gene ID" value="B7C42_02914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7225" checksum="455AA2F08CF57FA2" modified="2017-10-25" version="1">MNNDLSGAKWFKSSFSSSTKDCVEVAFLDDGVGVRDSKNPTGPALIFTPSEWSTFTASVEQGDFDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8C8</accession>
    <name>A0A231H8C8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45007">
        <property type="protein sequence ID" value="OXR45007"/>
        <property type="gene ID" value="B7C42_02964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="30664" checksum="19A38B5A147516D6" modified="2017-10-25" version="1">MAAPQYSLVVSSDLDHRRAAQRLRYRVFAGEPGFDIPFSADGLDADRFDEHCDHLLVRDEASGDFVGCYRMLPPDKVRAAGGYYTATEFDLSAMDPEGRRIVEMGRACVVPDHRNGSVLTLMWAGILHYIQLTGYDWVMGCVSVPMRDTPADPPGANVAAVRDLLLSKHAGDPARRVRPYRPVVVDGRGLDELDAPARPKLPPLLRGYLRLGAEICGEPAHDPDFGVADFVALLGLETINTRYLERLQSAAGAMDARAAEGTDARASQTDAARARDTGGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8E2</accession>
    <name>A0A231H8E2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Copper-exporting P-type ATPase A</fullName>
            <ecNumber evidence="10">3.6.3.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">copA_1</name>
        <name evidence="10" type="ORF">B7C42_03062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.54" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45105">
        <property type="protein sequence ID" value="OXR45105"/>
        <property type="gene ID" value="B7C42_03062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="774" mass="80880" checksum="DDB389A704983B22" modified="2017-10-25" version="1">MEDNGHGTVVLDLSGLHWASRQQVATRVLQARPGVLEATVNPAAQTATVGFDPARTSVHELRQWLRDCGIHCSGLSVPRHVCDPLAEPSEPAGAHRHEPAAPAHDHHGTHDHHDMSMAAMAADMRNRFLVALVFSVLVMMWSPMATDMFGIDLPVPFGLRQDVWALILSLPVIGYSSTIFFTGAWQALRARTLDMMVLVAVAIGAGWLYSLAITLTGGGEVFYEASTMLATFVLLGHWFEMRARGGATDAIRTLLDLAPPRAVVLRDGEEVEIPTAEVAVGDLLLVRPGAKIPVDGVVEDGDSEVDESMVTGESLPVHKQPGAPVIGASINVDGTLRVRADKVGSDTALAQIVNLVQQAQNSKAPGQKLADRAAFWLVLVALIGGAATLAGWLLAGATFATAMLFAITVVVITCPDALGLATPTAIMVGTGLGARRGVLFKNALALETAARVDVVVLDKTGTLTKGEPAVTEFVTSAAEPSPRLLAAVAAVERESEHPLAQAIVRYAEEGGVAPARAEKFENVPGHGAVATVDGQRVVVGNGRLLDREGIELGDLAAARARIADGGQTAVLVAVDDKAVAVVGLADAARETAAAAVREMHDLGVEVVMLTGDNRATADRIAAELGIDTVIAEVLPGDKADTIARLQSGGRKVAMVGDGVNDAPALARADLGIAIGAGTDVAIDTADVVLMRSDPLDVPTALRIGRGTLRKMHQNLAWAVGYNAVALPIAAGVFEPAFGFTLRPEIAALTMSGSSIIVALNAVSLKRLRLPQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8L7</accession>
    <name>A0A231H8L7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase IV</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dinB_2</name>
        <name evidence="4" type="ORF">B7C42_02488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45363">
        <property type="protein sequence ID" value="OXR45363"/>
        <property type="gene ID" value="B7C42_02488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="31"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="534" mass="57043" checksum="419E912CA7B87654" modified="2017-10-25" version="1">MKRPGFRVLAVWCPDWPAAAAAAVADLSPLRPVVVLHANRVVACSAVARDAGVRRGLTRREAQARCPDLHVAQADPDRDARLFEPVATAVDATVPGVEVLRPGLLVLAARGAARYFGSEEEAAERLVDAVAALGVECRIGIADELSAAVIAARRAQIVAPGAAANFLAPLPVGELAVEPSLAPPERAELVDLLHRLGLRRIGDFAALTPAEVASRFGADAIRAHRCARAEPERPPSAAPPAPDLVVEYRCDPPIERVDAAAFAGRMLATRLHERLAAASVACTRLAVHAETAAGEALSRIWRCAQPLTPETTADRVRWQLDGWLTHRARNTGKRGRTGDAEAPPSAPITLLRLEPVEVVAAGALQLGLWGGVGEEDQRARRALTRVQGLLGGEAVRIGVLSGGRGPVERVTLITFGEELVPAADPGLPWPGRLPQPAPAVVLGNRPEVRLESGDGSPIWLTDRGEFTAEPAELHWGKKSWLVAGWAGPWLLDERWWATGDSGGAVRVQILLDTEERALLLLGYDHIWHVEGLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9D3</accession>
    <name>A0A231H9D3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45459">
        <property type="protein sequence ID" value="OXR45459"/>
        <property type="gene ID" value="B7C42_02584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025350">
        <property type="entry name" value="DUF4254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14063">
        <property type="entry name" value="DUF4254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="18564" checksum="B4050B09F366DC3F" modified="2017-10-25" version="1">MVVVAWPDTPHTPTAVDFLTTEVLPSSDLLLRACRGHRVIGGPILWFARDLAVLFERQLGRGGSAPDPDSALMIEIGRRRMELVMAIDDWIVRAVPRQSSGATLHTETIGAVIDRLAEASVRAHHALMTLDANDEVLHGAWHHLAELADGYDDLVRDVLAGRRRLPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9E4</accession>
    <name>A0A231H9E4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rpsK</name>
        <name evidence="10" type="ORF">B7C42_02576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025347281.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45451">
        <property type="protein sequence ID" value="OXR45451"/>
        <property type="gene ID" value="B7C42_02576"/>
    </dbReference>
    <dbReference type="GeneID" id="66719007"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="14681" checksum="6A2B1F9B15C04ED7" modified="2017-10-25" version="1">MPPKSRASGPKKSQKARRRDKKNVPHGHAHIKSTFNNTIVSITDPEGNVISWASSGHVGFKGSRKSTPFAAQLAAENAARKAQENGVKKVDVFVKGPGSGRETAIRSLQAAGLEVGTISDVTPQPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9K2</accession>
    <name>A0A231H9K2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anti-sigma-D factor RsdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsdA</name>
        <name evidence="4" type="ORF">B7C42_02502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45377">
        <property type="protein sequence ID" value="OXR45377"/>
        <property type="gene ID" value="B7C42_02502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031928">
        <property type="entry name" value="RsdA_SigD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16751">
        <property type="entry name" value="RsdA_SigD_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RsdA_SigD_bd" evidence="3">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="41624" checksum="9E069BCD0B47437C" modified="2017-10-25" version="1">MARDGERGRGDWKARLGSPNSGPYAEASGESGDSGPVDIAAVRRDDALIDAIAGDGPVATDSAEEYQLASLLANWRADIVETPMPAGPDLDAVVAAVNQEIGAREARVNAHRRGRLRLVRPLMGAAAAVAVIAGGTTAFSYGAQPGDPLWRVKEVVFSQQAQTTIAQRADDDMTKAQTLIDQGHPEQAKALLESASTNTTQVDDNSRKQDLQLRWQHLLDQLKTTAPQVAAALESLEPKANTTPTTPTVVAPTTPGQSANPGQGQHESSGSKQNTPGPEIMRSQTAPETGANGSVPGTPGSEPGSGSKPPTQQQQQPPTTAEPPTHEQPPTQQQPPTNEQPPTQQQPPTNQPTANSPTTIGGGAVVPPTQPQQTVAPVRPSVPSAPTVVVPPAGGGLHTGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9R5</accession>
    <name>A0A231H9R5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45694">
        <property type="protein sequence ID" value="OXR45694"/>
        <property type="gene ID" value="B7C42_01986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="26391" checksum="783F2486BDD15B63" modified="2017-10-25" version="1">MEISGSSAIVVGGTGGLGEATVRRLHAAGAKVVVADVADDKGKELAAELGIRYVHTDATSEESVQVAIAEAQSLGPLRISVDAHGGPASGGRLVGKDGSPLALDGFRTTIEFYLTAVFNVLRLSAAAIAQSEPGEEGRRGVIVNTASIAAYEGQIGQLPYSAAKGGVVGMTLVAARDLSPLGIRVVTIAPGTFNTPAYGKAADQLETYWGKQVPHPKRMGRSPEYAQLVQSIVENDYLNGEVIRLDGALRFPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9T9</accession>
    <name>A0A231H9T9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadA_6</name>
        <name evidence="6" type="ORF">B7C42_02016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45724">
        <property type="protein sequence ID" value="OXR45724"/>
        <property type="gene ID" value="B7C42_02016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="258"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="39508" checksum="BDFD70B89B9A399E" modified="2017-10-25" version="1">MREVVIAAAVRTPIGKRNGALAGVHPVDLSALVLCALAERTGLDPALVDDVIWGCVSQVGDQSSNIGRYAVLAAGWPDTVAGTTINRACGSSQQAVDFAAAVVGSGQQDLVIAGGVEVMSRVPLGSARATGMPYGPKARARYHDFSFDQGISAELIAEKWGFTRTRLDDYAARSHELAAAAVDRGAFDDQIVDVTAGTATIVADEGIRRGTSAETLARLKPAFRADGVIHAGNASQISDGAAAVLVTTPDRARELGLTPLVRYRAGAVTGADPVLMLTGPIPATEKVLRRCGLSLAEIGVFEVNEAFAPVPLAWLAETGADLDRMNPLGGAIALGHPLGASGAVLLTRMIHHMRDNGIRYGLQTMCEGGGTANATVVELLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA14</accession>
    <name>A0A231HA14_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45680">
        <property type="protein sequence ID" value="OXR45680"/>
        <property type="gene ID" value="B7C42_01972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="100"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="29559" checksum="43E2E22D50DB2794" modified="2017-10-25" version="1">MVVMSASVDLRVYAELNDFVPPGARYVAQRRPIRPHQTVKDIVEAAGIPHTEVDLMLVNGESVGFAHHPRPGDRLAAYPVFETLDIAPATRVRPRPLRDPRFIVDVNLGGLARLMRLMGLDARIPSDTDDAALATAAADEHRIILTRDRGLLKRRTVTHGVFVRANRPLDQFVEVVRRLDLADRLLPFSRCLPCGGLLTDVAEQDVVDRLEPLTRKYYDTFRECRECHRIYWEGSHQRRLDDLVTRIRAAVGSDGQVHPAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA32</accession>
    <name>A0A231HA32_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">7-alpha-hydroxysteroid dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.159</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hdhA_1</name>
        <name evidence="1" type="ORF">B7C42_01898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.159" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821404.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45606">
        <property type="protein sequence ID" value="OXR45606"/>
        <property type="gene ID" value="B7C42_01898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008709">
        <property type="term" value="F:cholate 7-alpha-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="28238" checksum="5CC2E89625164C5F" modified="2017-10-25" version="1">MSLLSGKVAAVTGAGSGIGAASAKILAREGAAVVVSDINTAGAEATVAAITEAGGRAVATTVDVAVEEHIKAMVQLAVDTFGGLDILHNNAALVNPAFLGRDTTVVDIEAADWDRVMAINVRGPMLGCKYAIPEMEKRGGGSIIITSSVGAHHATVNQTAYGVSKGALDTLIKYVATGFGKRGIRCNGIAPGVVLSESALIALPPAVRDMHLMAQPTSRLGVPEDIGEMAAFLASDKAGYINGVTIPIHGGMTIINPHQVELWAHEGELVPFADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA47</accession>
    <name>A0A231HA47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45730">
        <property type="protein sequence ID" value="OXR45730"/>
        <property type="gene ID" value="B7C42_02022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012014212" evidence="2">
        <location>
            <begin position="39"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="72"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="464" mass="47757" checksum="724FEAB727EF30FA" modified="2017-10-25" version="1">MPVVSVPIRPRLIAAALTGVAVLFVACGCGSSSKPAPASTSPAAATTSPVPAVHPLDEPTLRGIVESVARPASVPGVVAFVRTAAGEVGTSYGTRTFGGGPAVTAADHVRIGSVTKTWTGTVILQQVQEHKLALDDPVSKYRTDVPGGAAITIAQLLDMRSGLYNYSETRELAEAMDADPGRVWQPDELLAMAYAHPPYFAPGQGYHYSNTNTILLGLIAEQLDGKPLEQIMRDRLFGPLGLTQTSFPARTSAAIPDPHPQGYMYGTNVLTMGTPPALPPEMQAEAKAGRLLPGDRTADNPSWAWAAGAGISTVGDLATWAEALSDGKVLDVDMQSKRMGSLQATDPANPPEAPQYGLAIAKFGALYGHTGELPGFNTFAGSDPAHKVTVVVWANLEPTADGNAAASAIAKQIIEHLYGTGTLPAGSATVPPGPTSAATATTPAAATPATPTPLSPTGAPTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAR5</accession>
    <name>A0A231HAR5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_10</name>
        <name evidence="1" type="ORF">B7C42_02109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45817">
        <property type="protein sequence ID" value="OXR45817"/>
        <property type="gene ID" value="B7C42_02109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="29866" checksum="CCB53B4808888ED6" modified="2017-10-25" version="1">MGWFEQRAGLAGTAAVITGGAGGLGRAIATDLAANGVHPAIIDIDADAVEHMRSALAAQGCDAVVVHGDVRDPDRLAEVFDAAEARWGRLDILVNVVGGTFRAAFTDTRPKGWDALLRSNLTHVLHACALAVPRIRAGGRGGSIVNITTIEAHRAAPGFAVYSAAKAAVEQFARTLAIELAPDGIRVNNVAPDYVPTPNLRRMPHGDAAMTDPRGVRVAIPLGRAGEVGDVSGCVVFLASALSAYLTGTTLHPDGGTGASAGWFNWPESGWANYAPMRYLAADTDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAV0</accession>
    <name>A0A231HAV0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein HsrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hsrA_2</name>
        <name evidence="7" type="ORF">B7C42_02274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45981">
        <property type="protein sequence ID" value="OXR45981"/>
        <property type="gene ID" value="B7C42_02274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="513" mass="53953" checksum="BE5671D4FBEFCD2E" modified="2017-10-25" version="1">MTSPPDIPAATSDPASDSLDAAVFKVAGVVVLGAIMSILDVTVVTVALPTFQHEFDTSYAIAAWTMTGYTLALASVIPLTGWAADRFGTKRLYILALTFFILGSVLCSTAWNIESLIAFRVVQGLGGGMLMPLGMTIMTHAAGPQRIGRVMAVLGVPMLLGPILGPILGGWLIGSFSWHWIFLINLPVGVIALILAVVVLPSDRPEPSESFDFLGMLLASPGLALFLFGVSSIPEQHTVASARVLVPAAIGLVLMVGFVFHALRTEHPLIDLHLFRNRQLTFAVLTAVFFAVAFFGSGLLLPSYLQQVQGKSTLVTGLLIAPQGLGAMITMPIGGKLVDKIGPGKVVMSGLAVIAVSMVFFTQLSADTSLPLMCVALFVMGLGMGCTMMPTMTAAIQTLTHAQVARGSTLMNIVNQAAGSIGTAIMSVLLTNMLENRPLAQAAIGSQFDPTIAQKLPPEQLDAGFDQAATAYAHTYIVALVLVLVTLIPAAFLPRSKPKLPQEGTDAPVLMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB39</accession>
    <name>A0A231HB39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_01005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46042">
        <property type="protein sequence ID" value="OXR46042"/>
        <property type="gene ID" value="B7C42_01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045977">
        <property type="entry name" value="DUF5933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19356">
        <property type="entry name" value="DUF5933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5933" evidence="7">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="194"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="448" mass="49047" checksum="91556D4AD07EC4E9" modified="2017-10-25" version="1">MLLDDPRSDFGDARRGRFRKWSPHIGVRVLLIAVPALLIVLQILAARNNFEGPLHSLWEDFAGTPKSVSVPWAGLALALVGLSWRWRFLAVGAAVIVDAVCATIRVLLGGPLTVGNGAVIALTAVALIAWLGWEGTRKRNALRAAALGSLLIIATKVGDVWLHFTVVAGPDVRDRYLVLADHAFGEPAWVMGRVIDALGPVVYGVLHWVYIELPVAAMVVAVWQLRKVVPTGTWPRHYLVRTFLVLGLVGPVIYLIFPVVGPMFAFGPDGHGLQVGNYWPHLVPPTDYHPEPMPFDRYTPRNCMPSMHTAWATALFLHTRRDNDGAPAPRWVRWPGTFWLLATLSATLGFGYHYGADLLAGAVLALTVESVLRAPERGWDRPRALLVAAGFTLLIGLLLAYRYLAVWMAEYPLPAGIIALGLFAGFVSAFYRTWFARTTADVAEPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBE0</accession>
    <name>A0A231HBE0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">trmB</name>
        <name evidence="3" type="ORF">B7C42_01229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46263">
        <property type="protein sequence ID" value="OXR46263"/>
        <property type="gene ID" value="B7C42_01229"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28858" checksum="897AD9A600E86F40" modified="2017-10-25" version="1">MDAVNDAANDTAGSDGAGGGSLRNHEGPAPEREPSRLYPRVTSFRSRRGALTATQQQSWERMWPRIGREVSDEPLDAAAWFGRTAPLIIEIGCGTGTATAAMAQAEPQFDLIGIEVYKPGLAQLVQRIEREGIENIRLLRGDAVDVLEHMIAKDSLAGVRVFFPDPWPKARHHKRRLLQPATMTLIASRLQRGGILHVATDHAGYAEHIAAVGAGEPQLVGLNEATGGDAEHPGTETVIGLERPVTKFESKAHRAGSAITEFIWGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBP3</accession>
    <name>A0A231HBP3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fatty-acid--CoA ligase fadD25</fullName>
            <ecNumber evidence="2">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46363">
        <property type="protein sequence ID" value="OXR46363"/>
        <property type="gene ID" value="B7C42_01329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="583" mass="60774" checksum="4CC7A350261E0D53" modified="2017-10-25" version="1">MTDRLAAAVAARAAEAPDDPAFTALAHPGGRQVAETVTTSQLHGAAGALAAAIRERTAPGDRVAIQCEHGLDYVVAFLGCLYSARTAVPLFPDTMRHNAGRLRTILGDAEPRLRLVSPGWAQPVPGARGPDAGRPPHGELLTVDAHARTDDVRVDTVGAHPAYLQYTSGSTTSPAGVCVSHANLAAALDQLRDALAPADDGPMVNWLPFFHDMGLVFALALPLYLGVHAITLPPSDFAKRPIRWLRACGEYRATATASPNFGLTLAVSGTSAEERDGLDLSSLDLLLNGAEPIRATALGAFTRTFAPHGFRHRAHTAGYGLAEATLPVTISRPEAEPICVEFDRAALGSGRAIVASAGHALGRADGLALVDCGRPAGQTVRIVDPITLTPREDGAVGEIWVRGPNVGAGYAGLRERTAATFGAVLPGEPGTWLRTGDLGFVHDGGLYIAGRLRDTIVIDGRNHFPADIEATAADSAPELRPGHIAAFGVDTGEREDLVIIAEMTSPPPAANDLGRRVRAAVATVHGVSPAEVLLLPRGAIPKTSSGKLRRGECRELYRAGEFGGGTGVEAALRPGNSARIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBY6</accession>
    <name>A0A231HBY6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">gyrA</name>
        <name evidence="11" type="ORF">B7C42_01420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781827.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46454">
        <property type="protein sequence ID" value="OXR46454"/>
        <property type="gene ID" value="B7C42_01420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="19"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="538"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="832" mass="92058" checksum="1EC9DCCBE5285CC3" modified="2017-10-25" version="1">MTETTLPPNGGAGDRIEPVDIQNEMQSSYIDYAMSVIVGRALPDVRDGLKPVHRRVLYAMYDNGYRPDRGYVKSARPVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSRGNDGAAAMRYTECRLTPLAMELLREIDHETVDFTPNYDGRSQEPVVLPSRVPNLLMNGSNGIAVGMATNIPPHNLNELADAIYWALDNYDADEETTLAACMERVKGPDFPTYGLIVGNQGIHDAYTTGRGSIRMRGVVEIEEDNRGRTTIVITELPYQVNTDNFINSIAEQVKDGKIAGISDIHDESSDRAGMRIVVTVKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQMIRLYVDHQLDVIVRRTRYLLRKAEERAHILRGLVKALDMLDEVIALIRRSANTDTARTGLMELLEIDEIQATAILDMQLRRLSALERQKIIDELARIEAEIADLKDILEKPERQRAIVRDELAEIVEKYGDDRRTKIVAADGDVADEDLIAREDVVVTITATGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDLVKHFFVTSTHDWLLFFTNLGRVYRAKAYELPEANRTARGQHVANLLAFQPEEKIAQVIRIKTYEDAPYLVLATRNGLVKKSKLTDFDSNRTGGIVAVNLRDGDELVGAALCSAEEDLLLVSAHGQSIRFTANDEVLRPMGRATSGVQGMRFNADDELLSLNVVRDGTYLLVATAGGYSKRTAIEEYTAQGRGGKGVLTIQYDPKRGSLVGALIVDDDDELYAITSGGGVIRTAANQVRKAGRQTKGVRLMNLGEGDTLLAIARNADEPDQVSGEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCF7</accession>
    <name>A0A231HCF7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46634">
        <property type="protein sequence ID" value="OXR46634"/>
        <property type="gene ID" value="B7C42_01608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="98" mass="10428" checksum="9A96075C700F444E" modified="2017-10-25" version="1">MSAADQHRIKAETALRRLPDEAIGLTPVGAEATAHALLYVGDQLAQLVEQQKLANVIAACALPEDRSPFDWPIKSAAGDYVYGRVGDIVNPATESDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCH6</accession>
    <name>A0A231HCH6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46654">
        <property type="protein sequence ID" value="OXR46654"/>
        <property type="gene ID" value="B7C42_01628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="55" mass="6276" checksum="713BD457133DBAEA" modified="2017-10-25" version="1">MTERAPYDFEMPTLQPGDPVSWVDRRGVMHHDIVTDYREEPRGSGNYVLETGGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCL5</accession>
    <name>A0A231HCL5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative peptide transport permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_01529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46558">
        <property type="protein sequence ID" value="OXR46558"/>
        <property type="gene ID" value="B7C42_01529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="109"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="350" mass="37450" checksum="9768D35BD3436584" modified="2017-10-25" version="1">MRFWIRGCGSDDRGWTVTETEIIAQGAPEPAAAGRRKLVWRRFLRNKPALVGAAVLIIMLIGAFAIPPLLSYDYQERDPYALLQPPSPQHLFGTNEIGQDMLAQTLHGLQKSLIIGICVAVLTSLIAVTAGSIAGLLGGWTDRAIMWLVDLLLVVPSFIIIAIFAPRTKGSSSILLLIVLLAGFSWMISARIVRGLTMSLREREFVRAARYMGASTRSVIVTHIVPNIASILIIDTTLAVGAAIMSETGLSFLGFGVQPPDVSLGSLIAFGTKSALTFPWLFLFPGGFLIAIVLCANLVGDGLRDAFDPSSKGARAGRKAGKRDKAPRGKSARTSGAGPDEQSDKRIEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCS3</accession>
    <name>A0A231HCS3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multidrug efflux ATP-binding/permease protein</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B7C42_01690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46714">
        <property type="protein sequence ID" value="OXR46714"/>
        <property type="gene ID" value="B7C42_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="49"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="366"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="400"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="623" mass="67450" checksum="D79F5C8AA2FE4BB3" modified="2017-10-25" version="1">MSVATTETVSDSEDDRTGTVAENSGARVTGAGSLRRLWPEIRPYRAALFGSAVLSGLGMLCDIALPFVTARIVDGPVAQRDFGGIWVPIALVVGLAVLSTVTSWWRRWIIAAPASRLEVSLRGRLFQRLQVLSVGVHDGMESGQLTSRAITDMSTLRRFFAFVAPSLLSLSATLGVGVALLFVLSWQIGLIELLIAVPLVLLALQFEQGYGSASRRAQDQSGHLATTVEESAQGIRVLKAFGRGPWFGRRFRAEARELQTLELAKVRLAARLWTALNTLSALGIAAALAVGGYLLTEQAMTVGALVAGITLTTYLQWPIMGFGFLLAEMNHARTAAQRFWEVIDTPVEITDPEHPVAPPQPLRGELRFDRVRFRFPDADRDLLHDISLRLRPGETVAVVGATGSGKSALLGLVPRLFDVAAGAVTIDGIDVRSMRLSDLRSQVSVAFEDPVLFSASVRENITLGYPDAGEERIRAALEVACAARFVDELPWGLRTRIGEQGLSLSGGQRQRLALARAVLDRQKHSGGHIVVLDDPLSALDVSTEEQVQVRLREALAGATVLLVAHRPSTAAWADRVAVLDGGRIIADGPHERLLETCSRYRELMGGELDAGEPERGRSFAHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCZ6</accession>
    <name>A0A231HCZ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46638">
        <property type="protein sequence ID" value="OXR46638"/>
        <property type="gene ID" value="B7C42_01612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="17748" checksum="56DD61F2B189C398" modified="2017-10-25" version="1">MTEPWPTVHTLAERVVINSEQRTITVDRHPLQSEVPPQVQLYKMGAGDGPDMLHGITITLRVNRLAVDSRGYLFVDDRLFPWLLSNNGPLISYYDRAFLITLELYAQRVDEVPQRVQLTDRGAAIVECGLSVRHMHELETGCSPDNLCAECRGYLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD48</accession>
    <name>A0A231HD48_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46627">
        <property type="protein sequence ID" value="OXR46627"/>
        <property type="gene ID" value="B7C42_01601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="10658" checksum="517DBEF703B3B2EC" modified="2017-10-25" version="1">MASVMKLPAEARIHASLSVARRERGMTQQQLAMRMRERGFNSWYSVTVSRVELGMRTLKLPEIITLALILGVALDLLVTAPPHAIRGCIRESGGAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDD5</accession>
    <name>A0A231HDD5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">qcrB_1</name>
        <name evidence="10" type="ORF">B7C42_01714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46737">
        <property type="protein sequence ID" value="OXR46737"/>
        <property type="gene ID" value="B7C42_01714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="528" mass="58763" checksum="F93D5AB1BBEE4C80" modified="2017-10-25" version="1">MAIADGADQRFRAAPFLKRSINKVFPTHWSFLLGEIALYSFVILLLSGVYLTLFFDPSMTEVVYQGSYQPLRGVSMSRAYESALNLSFEVRGGLFVRQVHHWAALLFAASIVVHLCRIFFTGAFRKPREGNWVIGSLLLILAMFEGFFGYSLPDDLLSGTGLRAAFAGITMGIPLIGTWLHWLMFGGDFPGTIILPRLYIAHVLLLPGIMLALIAAHIAIVWYQKHTQFPGPARTEKNVVGTRIVPVFVLDQGAFFMFTLAVVATMGGVLQINPIWNLGPYNPSHVSAGTQPDFYLMWTDGFLRLFPPWELYLFGHTVPSAFAVAVLMTLVFALLIGYPWIEKRLTHDRASHNLLQRPRDVPVRTAIGAMALAFYLVLTLACVNDIIALKFDISLNATTWFFRIALLLVPPLAYFLAYRMCLALQRADRAVLAHGIETGILRRLPHGEYIEIHQPLGPVDRAGRPVPLEYQGAPVPKRVNRLGLSGAPGSGSFLRPDSAGQREQLDAAAHEQERLHTATLRGHRDQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDK8</accession>
    <name>A0A231HDK8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranial dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">geoB_1</name>
        <name evidence="5" type="ORF">B7C42_00152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.86" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47033">
        <property type="protein sequence ID" value="OXR47033"/>
        <property type="gene ID" value="B7C42_00152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="17"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="491" mass="51803" checksum="86F5F449C518A5DC" modified="2017-10-25" version="1">MTDRLMYRREFYVGGTWVPPAGDERFAVISPSTEEAVGEVPVARTADIDRAVAAARTAFDDGPWPRLPPGERADTLARAAELLRKREADIAAVTVDEIGCPVSQSRQAQTGMVAALFDYYAELIRGFDFEHTVTAGDRSGLVTREPVGVVAAVVPWNAPVTLAAWKAAPALAAGCTVVIKPPPESPLSNFVLAEALDEAGMPSGAVNIVPGDREVGEYLVTHPDTDKVAFTGSTVAGKRIMSVCGERVRRVSLELGGKSAAVVAEDSDIATVLPAIVKGAMHMSGQVCGAHTRVLVPRTRYAEAVDAAAAAAAAVRVGDPHDPATLVGPLVAQRQRTRVEHYIALAREAGARVVTGGGRPAGLPRGWYVEPTILAEVDNAMRVAREEIFGPVLCLIPHDGDDDAVRIANDSPYGLSGGVWSADAERGLAIARRLRTGSIAINGTYPPFPRVPFGGFKESGLGRELGPEGLHSFLEPRSIGLPAALRRDAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDL3</accession>
    <name>A0A231HDL3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_1</name>
        <name evidence="6" type="ORF">B7C42_00026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46912">
        <property type="protein sequence ID" value="OXR46912"/>
        <property type="gene ID" value="B7C42_00026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="293"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="329"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="555" mass="59421" checksum="92974C5C313B1183" modified="2017-10-25" version="1">MSDHSDTEPVEPLLRVRDLSVAFRAGRTEHAVLHHVDLDIAPGEIVALVGESGSGKSTLSRSVIGLLPSGGRVTGGSIRFAGRELTTASASALARLRGREIALVPQDPATSLNPVRTVGSQVAEIFRLHPDLSGVARPDAASIRKQSIALLDLVGIDRPDVRYDQYPHQLSGGMRQRVLLAIAFGLRPKLLIVDEPTSALDVTVQRQVLDVLDGLAHEFSVSVLLVTHNLAIATDRAHRVAVMRGGRAVETATVDDIIAHPGNPYSRELLRNAVAAHLSRPPRGRAGNAQPAVVVGDLGKVFDVGTEKLHAVRDVSFTVARGETFALVGESGSGKSTTAKLVLGLHTPSSGTVSVLGHDITAAKHRDRRELWRDIQLVYQNPQVSLDPRWNVERIVAEPLSSFGLVKGRAARRDRVREALDRVGLPAAVLDRRPRELSGGQQQRVALARALAVGARVLVLDEALSALDVVTQAQVLDLLHRLQDELELSYLFISHDLAVVRAIADSVAVMHQGRIVESGPVGQVLDNPTDPYTRGLVAAVPGHRLTDPTALAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDV5</accession>
    <name>A0A231HDV5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46948">
        <property type="protein sequence ID" value="OXR46948"/>
        <property type="gene ID" value="B7C42_00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="27962" checksum="2251542FDC9A4D4A" modified="2017-10-25" version="1">MHNTRSQRLCVWSGPLFALLFFIGYGVVARYIPPPDPDRSAAQVAEFYRGHANAIRLGMVLSMFGLVFWVPFVAAISVQLKRIEGRHSPLTYAQLGLGATLPVAFIPALYYFEVAAYRPQRSDESIQMLNDMGWLPFTGIIYAIFVQNIVIGVAVLSDRRTVPIFPRWYGYFCLWSGLLYCPACLDVFFTHGPLAWNGLFSWWLSLVAFFVWLIGTTVVTLRAISAQALATGAESDQPAATHTRPGLFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE00</accession>
    <name>A0A231HE00_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,8-cineole 2-endo-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.156</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cinA_1</name>
        <name evidence="4" type="ORF">B7C42_00171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.156" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776972.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47052">
        <property type="protein sequence ID" value="OXR47052"/>
        <property type="gene ID" value="B7C42_00171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="45344" checksum="C701C7AADD00F5E7" modified="2017-10-25" version="1">MEKTTPNGVRLPDDWCLRQFDHLSPELAATLPETMARMRELCPVAHSDRYGGFWVASGYEEVLSVAQNWSVFSSAHGLSVTGTKGVVRNLPVEVDPPEQRAYKSLITPYFTPAAVADWERPTRDLVTRLLDGFLADGQCEFMDAFARPLPSLAFFELAIGAPADELDTVSRLASRSSIPNHPESRECWKGLYAWVKGFLADRREQPPRGDVVDAVLAAEIDGVPLTEDETIGAVQLLILGGLETTAGALGLMVERFCREPEIPQLLRERPELMPKAVEELLRLDSPFVSVGRTAVRETELAGHTIESGDKMLIHWASANRDAGEFPDPDRFDPNRTRNRHFAFGAGPHRCAGSNLARLNLRVALEEIVQRMDRIAVRDGAEIRYHAGLTRSPLSLPITFVAREPDRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE08</accession>
    <name>A0A231HE08_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF853 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47008">
        <property type="protein sequence ID" value="OXR47008"/>
        <property type="gene ID" value="B7C42_00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="2">
        <location>
            <begin position="99"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="574" mass="59716" checksum="9186E09610997055" modified="2017-10-25" version="1">MTSSEDKAAKAAAARKAAEEAARVAAEAAAAAEAAEAEAAAEPAADATPADSATAAAAADAKPAAGETNSVARQIAAGYAFEGAALELGAVVVDGEIDPAARVRIPMRTLNRHGLVAGATGTGKTKTLQGIAEQLSAAGVPVVLADVKGDLSGLAQQGESNDKLAARAAQTGDADWAPHGFPTEFVSLGTEGIGVPIRATITSFGPVLLAKVLGLNDTQESTLGLIFHWADTRGLALLDLKDLRSVIQHLTSPEGKEDLKGIGGVSAATAGVILRALVNLEADGGDTFFGEPELDPADLLRTAGGQGVITLFELGSQAARPVLFSTFLMWVLADLFQTLPEVGDVDKPKLVFIFDEAHLLFADASKAFLEQVEQTVKLIRSKGVGVFFCTQLPTDVPNAVLSQLGARIQHALRAFTPDDQKALSKTVRTYPKTAAYDLENALTALGIGEAIVTVLSEQGAPTPVAWTRLRPPRSLMNTIGDDGIRSRAQSSSLFEKYGRTVDRESAYEMLTAKVVAAEPEPQPVPQGSGGRAPEPDVSAAERIMSNPAVKSFLRSAASAAGREISRSLFGTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE34</accession>
    <name>A0A231HE34_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-[(3aS,4S,7aS)-7a-methyl-1, 5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fadD3_1</name>
        <name evidence="4" type="ORF">B7C42_00323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.41" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47201">
        <property type="protein sequence ID" value="OXR47201"/>
        <property type="gene ID" value="B7C42_00323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="19"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="487"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="572" mass="60693" checksum="4572AEFA3E65CF7B" modified="2017-10-25" version="1">MVCEEMTAEPATIPALVSAQAHRNGSTVAIVEGSARLTYAGLHTEALRVTRAAMARGVAAGDRVAIWAPNSAHWIVTAVGLLGAGATVVPIGTRLRGPEAAALLRRTRCRGLFTVRGFLGIDYPWLLADQGPLPDLEFTVLLSGTYATDDSATSPSMSDDDQDPPTGVARSVTGSGHRRRDRREPDGCARRPPDRRESAPIDWRDFIADAARIRSSDAESRIAAVPSDAISDILFTSGTTGSPKGVLTTHRQTLTVLDRWASAVTLRHGDRCLLVNPFSHTFGYKAGIVACLLRAATMVLVAVFDPRAVADLMTSERITVLAGPPTVFTDLLAVGRSYPELRLAGTGGTAIPADLIARMRAGLGADQVFTAYGLTESVGVVAVCPPGTDIERTAHTVGKALPGSEIRILSADGREVPVGMPGRIVVRGPNVMSGYLDDPDATAAAVDPQGWLHTGDVGTLDADGYLRVTDRLEDMFIVGGFNVSAAEVEQTLLGYPGIAEVAVVGVPDERLGEVGAAFVVPAGTAPFDADDLLAWCRTRLAGYKIPRMVRILDRLPRTTEGKVRKRRLRCAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE73</accession>
    <name>A0A231HE73_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ECF RNA polymerase sigma factor SigI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigI_1</name>
        <name evidence="8" type="ORF">B7C42_00196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47076">
        <property type="protein sequence ID" value="OXR47076"/>
        <property type="gene ID" value="B7C42_00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="428" mass="46474" checksum="23C20A2AA474FDB2" modified="2017-10-25" version="1">MPGSQVPAVPVGRPSERDEQRADSAQEAALLLREVAPVVLGILVRRYGDFDAAEDAVQEAMLAAVTQWPDKGYPDNPRAWLLQVAQRRLIDSVRSEIARRSRETTAALRDVPPADTDSAADDTLTLLLLCCHPALSPASAIAVTLRAVGGLTTEEIARAFLLPETTMAQRISRAKKRLGALPRPFAESAVAPEDWGSRLGPVLHVLYVMFTEGHTATGGSRLYRTDLAAEAIRLTRKVHRLLPDDPEVTGLLALMLLTDARRAARLGPSGELIPLAEQDRTRWDRDRAREGMGLATAAVEAGLGGPYRVQAAIAALHTRAPSAEETDWERILLLYNVFERLSDNPMVSLNRAVAVAMVHGPAAGLESANTLADRLRGNHRLDAVRGHLYEMAGDRATAIESYTAAAHLTTSTPERDYLMLRAAKLRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE97</accession>
    <name>A0A231HE97_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndk_2</name>
        <name evidence="3" type="ORF">B7C42_00301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47179">
        <property type="protein sequence ID" value="OXR47179"/>
        <property type="gene ID" value="B7C42_00301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="2">
        <location>
            <begin position="45"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="33103" checksum="48D5A8118DE1EFCA" modified="2017-10-25" version="1">MTLAQLLAASTPLPDKAAAYAEDTYVQETVDQLSAAGLDAADFSRRYSLLLLKPDAIVARAVEPTLRWLRDNDFRVVAARTCAVDRHLVRALWYFAWNIASAERRRLADLLTEISDALVLVVSGEPTALPTSVRLTTAKGPTDPGKRQPGELRYLLGRYSYLLNLVHSPDDPADVLREFAIYFDTGTRARVLREIESGRDRGVEAAACAAELYSRTPARDFGRSAATTRLLADVGDVPADFDPDRDEDCALLLRRAWATGRAIDPWSAIVLGSHVLPMRNGGRRQILPPVSAHDWLEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEK6</accession>
    <name>A0A231HEK6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low molecular weight protein antigen 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cfp6</name>
        <name evidence="3" type="ORF">B7C42_00524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47401">
        <property type="protein sequence ID" value="OXR47401"/>
        <property type="gene ID" value="B7C42_00524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20342" checksum="8C9256E148C35C8E" modified="2017-10-25" version="1">MSSPQQSVPPAQSSHTAEGGTDTGRVIRIPRLAHLGVFILLFCAAFPFFGWPAVLWILFLIPIAAAWWVERSRTTVSAGGLDLRTIFGTRHVDWSQIQGLRIPKRGWVRAHLSDDSEVALPAVSYDRLKDLIAASDGRIPDPFARPAKSAASADEKSGEQDPSADTGAESGGADSASTDVADKQDTSTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEM8</accession>
    <name>A0A231HEM8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Molybdenum import ATP-binding protein ModC</fullName>
            <ecNumber evidence="9">3.6.3.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">modC</name>
        <name evidence="9" type="ORF">B7C42_00462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.29" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47339">
        <property type="protein sequence ID" value="OXR47339"/>
        <property type="gene ID" value="B7C42_00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="8">
        <location>
            <begin position="284"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="37412" checksum="8409F1BE9062219C" modified="2017-10-25" version="1">MTLRAELEVRRERFRLDLSLSVAPGEVVALLGPNGAGKTTALRALAGLVPLTGGRLTVADAVWDEPPGVFVPPEQRQVGVVFQDYLLFQHLSALENVAFGLRARGMRRARARARAADRLARVGLAEHAHATARTLSGGQAQRVALARALATDPQLLLLDEPLAALDAGTRMQVRAELARHLRDYRGHTVVVTHDPLDAMVLADRLVILEQGTVVQQGAPAEIARRPRSDYVADLMGLNLFRGTADGTGVEIDNGGHLTVASPATGRVFLAFPPTAVSLHLQQPTGSPRNSWAVTVGGLEHHAHLTRVRLDGAPPVLADITPAAVADLRIQPDMRVWAAVKATEIHVYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HES1</accession>
    <name>A0A231HES1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47481">
        <property type="protein sequence ID" value="OXR47481"/>
        <property type="gene ID" value="B7C42_00606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="21004" checksum="5E194FD4B4B3404D" modified="2017-10-25" version="1">MRKLTYFVASTIDGYIATPDGSVDFFPVGGDHGPAITAQYPETLPTKIRESLGIDSPGESFDTVLMGRKTHDFGVRTGTSSPYSHLRQFVVSTTLPGDPDRDVELISSDPLGRVRGLKQEQGSGIWLCGGGELAQALLPEIDQIFLKLYPIVLGHGRPLFGAGPRLPEPALFRVLTGRVFEDGVAFVKYSRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF16</accession>
    <name>A0A231HF16_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione transport system permease protein GsiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiD_1</name>
        <name evidence="6" type="ORF">B7C42_00678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47553">
        <property type="protein sequence ID" value="OXR47553"/>
        <property type="gene ID" value="B7C42_00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="83"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="30121" checksum="E248C67D3F5F3AD7" modified="2017-10-25" version="1">MSRWSEVLRESPGARLRSVPWPVWIAAIVFAFLVVAALAPHLVTGVDPTAMARRQTLRPPSGEHLFGTDQLGRDVFARTVHATRISLGIGVAATAIGFGLGAVIGLLASGPSRLLDAVLMRLTDTMLAFPGMLLALVVIAVSGPGARNSAIAIGLATIPYYARLVRSQALEVRHSGYVEAARTLGQSRSRIALRHVLPNALTTLVVLATLGVGTAIVAGAGLSFLGLGVIPPTPEWGSMLSEGRNLVGRAWWIGVFPGLFVVASVVSITVLSRYWQRLAEGRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF26</accession>
    <name>A0A231HF26_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YtcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytcD_1</name>
        <name evidence="2" type="ORF">B7C42_00439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47316">
        <property type="protein sequence ID" value="OXR47316"/>
        <property type="gene ID" value="B7C42_00439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14600" checksum="B3237F385ED55EB4" modified="2017-10-25" version="1">MELTNDSGGAVAVGPCASIPAEHMDFIRQVLDRVGDKWSLLVIAVLDTGPLRYTDLQRQVPGISQRMLTLTLRQLQQDGLISRTAYAEVPPRVEYALTSLGRGLHEIVSSLIGWAAEHHDEIRAHHARTAIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFN3</accession>
    <name>A0A231HFN3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cpxA</name>
        <name evidence="10" type="ORF">B7C42_00620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47495">
        <property type="protein sequence ID" value="OXR47495"/>
        <property type="gene ID" value="B7C42_00620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="128"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="345" mass="37353" checksum="F4103F0E9C42AB68" modified="2017-10-25" version="1">MCSARFPRLPRRQLLRGRVIVAFTVTGLVSALLAVLIAKLDGGGWRTALACALGGTVIGAIFGIWLSHRLLEPLRQVTGTAAKIASGELGTRLPDTDDPDLAPTVDAFNTMVDSLQNRIDRERRLVGDVSHELRTPLTTLTTSVGVMSRYEDQLPERSRRALDLVRAELDHLRRLLDDLLALARAEARMHGADAEPLSVRALLTHTLAEMHYSPELLTVADDGIVTGRKLELERALVNLLENAQRHGGGVIAVGVARAGDEMVITVDDAGPGVAPQDRQRIFERFVTVRRGKRSGTGIGLALVAETVAAHGGRVKCDDRPGGGARFMVWLPTVTKFTDHTSVTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFR4</accession>
    <name>A0A231HFR4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthetase [glutamine-hydrolyzing] 3</fullName>
            <ecNumber evidence="8">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">asnO_1</name>
        <name evidence="8" type="ORF">B7C42_00672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47547">
        <property type="protein sequence ID" value="OXR47547"/>
        <property type="gene ID" value="B7C42_00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="6">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="607" mass="66970" checksum="BF1697CFAC902A83" modified="2017-10-25" version="1">MSAITGWLDRDRDLREHTATVRAMSDTLAHRGPDGGGIWLEQRIALGRNVLAVADLLDNGQPVVTGEAGRPIAVLTLSGEIYNTAELRHELSVRGHAFTGATDPDAEVVLHAYLEWGADAVRRLDGMFAFAVWDVRRGELLLARDRLGIEPLYYAEHPGGLLFGSEPKALLANELFRPQVDAEGLIDIFTVAMRRPGDAVYRGLREVRPGWIVRADHNGLHHHRYWQPVSAPHTDDVDTTIATLRELLTDIVERQTRTGTAAGLLSGGLDSSVITALAARARGDAKLATYSVDFAGSDTDFTPDALHVSRDAPYVRAVVDHVGTDHTEVLLDAPALLDEMGETLRARDIPGVGDLDVSLYLLFREVRRYADVVLSGEGADDIFGGYPWFAAEATASSGSFPWAAGNTDRNAMLSPELRAHLDLDAAVVDRHREAVAELAPLAGEEGPDRRVREVFHLELTRFLPFLLDRKDRMSMRTGLLVRLPFCDHRLVEYLWNVPWDLKRHGGQEKGILRAAAEPWLPPQVAKRPKSGFPFGQSPHYLAAVREATRAMLADPSAPALALLNTGALAELAEGDRWHSGTFTPPPWLPRALQLNTWLRDYRVEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSJ3</accession>
    <name>A0A231GSJ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000227">
        <property type="protein sequence ID" value="OXR39590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39590">
        <property type="protein sequence ID" value="OXR39590"/>
        <property type="gene ID" value="B7C42_08342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8885" checksum="35B78621FC469D3E" modified="2017-10-25" version="1">MQTALARLGRYDEEIDPPPGLTDARCWKIDDRDPVRSSTYKCALVRGRYVAVVESARMTFDAGLYQRAAAQYSILAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSK8</accession>
    <name>A0A231GSK8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_08315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000134">
        <property type="protein sequence ID" value="OXR39617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39617">
        <property type="protein sequence ID" value="OXR39617"/>
        <property type="gene ID" value="B7C42_08315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="PTHR11884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR39617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="16559" checksum="828F7246B6EDA6C3" modified="2017-10-25" version="1">MAICLTKQQDEEAKGNIEGKTLTDDCKGELAAFKIELGESINKNLALAKACKEDATKLCADQDPTDPVAVLTCLRDLKDSLSATCSAEIFNTQLEAAKDYRTDADLHAACEPDAKQLCANVNPGEGRIQDCLPRQGRLRVLGVPGGALPPGGGECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSP5</accession>
    <name>A0A231GSP5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000103">
        <property type="protein sequence ID" value="OXR39650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39650">
        <property type="protein sequence ID" value="OXR39650"/>
        <property type="gene ID" value="B7C42_08281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="130" mass="14392" checksum="8617EF60FD4813F5" modified="2017-10-25" version="1">MEKAVIADVIDSVEYRDDYVGGGVDPHGNVHGPYWLTSITPDCYLPRDRSAIRSVLDEWLAIGGALPSVLRSAIDVALRPLHDPAISCYELPRLSDSAINDYADIHNEYHEFLLISRNEKTAVLLVASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSV0</accession>
    <name>A0A231GSV0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000103">
        <property type="protein sequence ID" value="OXR39652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39652">
        <property type="protein sequence ID" value="OXR39652"/>
        <property type="gene ID" value="B7C42_08283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="50" mass="5593" checksum="2B6F566FD936FA99" modified="2017-10-25" version="1">MIVDWQIYYDAALKCQQIADDIRRADKPVHDAVKGECAGMAGQLGCRQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTS2</accession>
    <name>A0A231GTS2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782737.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40024">
        <property type="protein sequence ID" value="OXR40024"/>
        <property type="gene ID" value="B7C42_07908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8295" checksum="D34D49E589338B01" modified="2017-10-25" version="1">MTTTRLDPKVLAPLTQLLGWLAWLVLLLAIARTIWIGWQLAWRLHRDEAIEGLAGALLAAVLVGSASGIAAALFPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTS5</accession>
    <name>A0A231GTS5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytochrome P450 YjiB</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yjiB</name>
        <name evidence="4" type="ORF">B7C42_07943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39992">
        <property type="protein sequence ID" value="OXR39992"/>
        <property type="gene ID" value="B7C42_07943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="435" mass="47798" checksum="95F0F9737CB87D03" modified="2017-10-25" version="1">MTTTDSPMKALFDGDAKSIQCPYPSYARLRNEAPVFHDPEHDIYVVTRHADIEAVNTQPKLFSSQNPIGPTVTEAVTAIGRALSEASPEFIERVRVVLAKGDVLFTQDPPVHTRHRRVLNKALTPRAIARIEPQIREACHELIDGFATPGEPCEVEFISAFCDPAPIRVLAALLGVSAERSADFARWADAINSSTGTTMSNEALLASLDTQAEFWQFFEAEFADRVENPGDDLLTSIVQARDDDGTPLTPNEMVAFCSQLVAAGADTTSKLISSFMYMLCEDPELMARVRSHPDDLPRCLEEALRLESPIQGLFRIATADTEIGGVPIPAGAQVYVVYASGNRDESIFDEPCKYDPDRDRLRSHQAFGHGPHACLGATVARTVARISFEVLLERLADIEPAESGFVPHYSPNYIIRGMESLPLRFTGVARRGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUL7</accession>
    <name>A0A231GUL7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909919.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40317">
        <property type="protein sequence ID" value="OXR40317"/>
        <property type="gene ID" value="B7C42_07578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="366" mass="39272" checksum="6DE3EB569E6D9912" modified="2017-10-25" version="1">MTDMTRPDVDFYTPPALDGLHRPGDILRLRPAPALSGADQAWQILYVSRDSCDQPIPVSATVITPDASAPDLGGAVLVYYPSFHGLGGPSASQLLAMGAEPDGAQIRAALARGFVVAVADGEGLGVIGYGPHTFLAGRAGGQVMLDLARAATRVPALNAAESPVVFWGYGDGGRSAVWAGGLQLVCAPELDVRGIAAGAVVTDPGQALRSVNRGAWAGLGLAALIGLSHAHRRLPLRHIFTEESRQSVVGEAEVSNRGRFFERYRHPVGVWCERTDVWNDPLWQHVFALELINASLLPAAPIYLYHGSTDGIVPVTFGRRLAHEFRTRGAPVGWREYDGDHCRTARTAIDDVFDQLTEYLTRPTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUS5</accession>
    <name>A0A231GUS5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40374">
        <property type="protein sequence ID" value="OXR40374"/>
        <property type="gene ID" value="B7C42_07540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="34" mass="3770" checksum="7115335CD9B9EF65" modified="2017-10-25" version="1">MAAYQGSALLSNTLRDPTILTIAARRLTHWLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUT8</accession>
    <name>A0A231GUT8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA:oxalate CoA-transferase</fullName>
            <ecNumber evidence="1">2.8.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uctC_6</name>
        <name evidence="1" type="ORF">B7C42_07559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.19" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40393">
        <property type="protein sequence ID" value="OXR40393"/>
        <property type="gene ID" value="B7C42_07559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="380" mass="40484" checksum="7015ED5DC721E5FE" modified="2017-10-25" version="1">MRPLHGVRVVEFAHVAAGPFTGMLLADLGADVVKVEPPTGDQMRVWPPFADDGDERFSHNFASVNRNKRSVVADLRDPGDLARVRDLVAAADVLVENYRPGVLDRLGVGYEQVRHPGFVYCSISGYGLTSPYVDHGAYDVVIQGMSGLMSVTGEPGGGPVKAGVPVGDFTAGLYAAYSIAAVLPQVRAESRSVRLDCPMLDCLLGVSALQTSEFWGSGVEPARLGTAHPRNAPYQGFAAADGDFTVAAGNDRLWAAVADVVGAPELADDPRFLTQLDRVAHHAELAAILQERFASAKRDHWIAELRARGVPCGPVNSFGDILSDEHVRATGLVGSLDVPVAGPTPTVVFPVRIEGQDPRLDRAAPRLGGDDEIFDEWCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUU5</accession>
    <name>A0A231GUU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msuD_3</name>
        <name evidence="2" type="ORF">B7C42_07560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783555.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40394">
        <property type="protein sequence ID" value="OXR40394"/>
        <property type="gene ID" value="B7C42_07560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="373" mass="40748" checksum="DEA6227DF95C210B" modified="2017-10-25" version="1">MSYDDVEILGMIGTADASETRPGNGAVIDPDYTIRFARAHEDGGFDRVLIGYGSGWPEGSQVAAAVAAHTERLGLLVAHRPGVVHPTLASRTFTTLDQFSGGRVALNIVTGSTDVEQRREGDYLPHDERYARTDEYLRILRAAWDTTGPRDFDGDYYRFEGFHPHVPPHGNRHLELFFGGSSPAAYTVGARHADTYMLWGEPLRETAEQIATVTERAAAAGRDRRPRISVSFRPILGATDEAAWERAHRILDTITGGADNLRANQLHPRGAEPQNAGSRRLLAVAERGELHDRCLWTPTAKAVGGGGNSTALVGSPETVAAALLDYIEIGVNTVLIRGYDPLQDAIDYGRDLLPLVRQELAHRRATRSDRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUW3</accession>
    <name>A0A231GUW3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein Stp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">stp_17</name>
        <name evidence="8" type="ORF">B7C42_07538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40372">
        <property type="protein sequence ID" value="OXR40372"/>
        <property type="gene ID" value="B7C42_07538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="24"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="495" mass="52298" checksum="B8392DB1B2370BDD" modified="2017-10-25" version="1">MQEALRQEPGRRRLVLRSRLGVAVLVLLCAVQFLDIVDSAIVNVALPSIQHSLHFTQQNLQWVASGYILTYGGFLLAGGRLGDLLGRRRMLFAGLVVFASSSLTAGLTDDAGLLIAARLVQGIGAAFMAPAALSELTTSFREGKDRDTALGVWGGISGVAAAAGVFLGGIIAQGPGWRWVFFVNPPICVAVIACAVMLLADDRPSRTGRAAFDSHGAVLLTGGMLLLVYGLVRAPIVGWGSLSTVLCLGGSAALLAAFALNEARTRDPLVPAPVLRVKGLVAADLTQLIAFAGFFSLLFYATLYMQEILHYSPCRRQPGRLRRDARVGRGGDCDEHRPRPQRHHEESRQEIFEVGTVHRHLGHVIDACPGEQAAHDHHRAGADARDQLRRNASGDGEPGGDRKVGESGPDRRNSSQQVGSAAGLAILSAVAITRTDNLIAAGASAAVAADSGYQRALLVGAILMGVAALIALRTGNTRMRAPLVMVDAEASYPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUZ4</accession>
    <name>A0A231GUZ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carnitinyl-CoA dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">caiD_10</name>
        <name evidence="6" type="ORF">B7C42_07507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.149" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778545.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40449">
        <property type="protein sequence ID" value="OXR40449"/>
        <property type="gene ID" value="B7C42_07507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="26182" checksum="82C523DF1369CE99" modified="2017-10-25" version="1">MDKPVITQTFGNVMVITINRPEVRNAIDSRVFHGLGDAANELDERSDLAVGVLTGAGGTFCSGMDLKAYSAGNFGSGGRNLTADPPTKPLIAAVEGWALAGGCELALACDLVVAAENATFGLPEVTRGLIASGGGLLRLPKTVPYRIAMEIALTGAHFTAELACRYGLVNRLTPPGSALEEARRLAETISMNAPLAIRATKAVIRDSAGWTDASAWAAQAPVAAAIFDSDDAREGARAFVEKRTPQWSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV11</accession>
    <name>A0A231GV11_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acsA_8</name>
        <name evidence="3" type="ORF">B7C42_07405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780080.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40467">
        <property type="protein sequence ID" value="OXR40467"/>
        <property type="gene ID" value="B7C42_07405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="49"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="455"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="567" mass="62631" checksum="0E1C5BE5D4AA7AF4" modified="2017-10-25" version="1">MTSNTEVYRQARDRLVELATDYDTAVRTFEWPRLTGTFNWAVDWFDVIARGNDRTALWIVEEDGSELRVSFDEMARRSDRVATWLAELGVRQGDRVILMLGNQVELWESMLAVAKLGAVVMPTTGALGPADLIDRITRGEVRFVLTNARDTAKFDEVPGDYRRIAVGGPVEGWHDYAEAAAVESAGPFPAVTQVGDELLVYFTSGTTSKPKMVQHNQTSYPVGHLSTMYWIGVRPGDVHLAISAPGWAKHAWSCFFAPWIAEATIFVYNYGRFDAEALLGQLRRAEVNTFCAPPTVWRMLIQADLGERPSGLREILGAGEPLNPDVIAQVENAWGLTIRDGFGQTETTLQIANTPGQPVKAGSMGRPMPGVPVVLVDPVTGLPAEEGEICLDLSAHPVNLMNGYLQDPERNAAVMAGGYYHTGDVAARDDDGYITYIGRTDDVFKSSDYKVSPFELESVLIEHPAVVEAAVVPQPDDTRLAVPKAYVTLAAGWEPDRETARAILEYARDHLAPYLRVRRIEFTELPKTISGKIRRVELRQREEAAHAAGTGIAQEFRYEDVLAQPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV13</accession>
    <name>A0A231GV13_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40464">
        <property type="protein sequence ID" value="OXR40464"/>
        <property type="gene ID" value="B7C42_07402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="16003" checksum="A1F1D1B38EF04852" modified="2017-10-25" version="1">MTKPATPSDSFKTAPPAAPYGDAMAPQLNAIGVVVSDLTAALGFYRRLGLEFGEVVGGGHVEAPLPGGFRLMLDSEENIAQDVGGDRRWNAATGRIGLAVECRSAAEVDAVFDDLVAAGYHGETKPFDAVWGQRYATVHDPDGNGVDLYAPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVB1</accession>
    <name>A0A231GVB1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carnitine transport permease protein OpuCB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">opuCB</name>
        <name evidence="6" type="ORF">B7C42_07368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40559">
        <property type="protein sequence ID" value="OXR40559"/>
        <property type="gene ID" value="B7C42_07368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="43"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="25296" checksum="53E61FEF9B020FFC" modified="2017-10-25" version="1">MAVPLVACARAAGSIDCSNAAELWEDIALDTLWTFLVDHRRQLLTDSYLHVSAVVQSVLIATAVAVCLGIVVYRSPWGSAAATAAASIILTVPSFALLGLLIPVLGLGVRPTVTALVLYALLPILRNTIIGLASVDPAVSDAARGVGMNRVRILARIEMPLAWPSILAGMRISTQMSMGILAMAAYAKGPGLGNLIFTGLARLGSPTAVPQALSGTVLIIVLALLLDAVLVGVGRLTTSRGIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVJ3</accession>
    <name>A0A231GVJ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">7-alpha-hydroxysteroid dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.159</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hdhA_2</name>
        <name evidence="1" type="ORF">B7C42_07429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.159" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40491">
        <property type="protein sequence ID" value="OXR40491"/>
        <property type="gene ID" value="B7C42_07429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008709">
        <property type="term" value="F:cholate 7-alpha-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="275" mass="29671" checksum="1B55A372A218EE93" modified="2017-10-25" version="1">MSTTDQPIATTDTYRPLPLLEGKVVVLSGVGPGLGRALGAEAARMGADLVLVSRTERRLEKMAEVVRSHGRKALVVPTDITDEEQRNALVERALAEFGRVDCLINNAFAIPPMEPITGIELDALRTANETNVFAPLRLSTLFADALAATRGSIIMLNSCVSFDSEPVYAGYKLSKGTLAHLASSLATELGPRGIRVNSVAPSYIYEDVNKAYFDWLAAQDGVTHEEIYRRKAEPTDLKRLAAPEEVARAALFLASDLASAVTGQILTVDCGEYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVN5</accession>
    <name>A0A231GVN5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40689">
        <property type="protein sequence ID" value="OXR40689"/>
        <property type="gene ID" value="B7C42_07247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="73" mass="8207" checksum="011C5D0A770E0BF9" modified="2017-10-25" version="1">MRRPRSLPPAFTFLLRERPTDTDKITPLVLSSLPRILVMENNFGFTPGHAELPAPVERYLYILEPPASAPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVV7</accession>
    <name>A0A231GVV7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40759">
        <property type="protein sequence ID" value="OXR40759"/>
        <property type="gene ID" value="B7C42_07183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011269347" evidence="2">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="13552" checksum="C56360219CD27B49" modified="2017-10-25" version="1">MKRPTIVSAALFLACFASAVLLLAVADHKLDERSDALLESHCARTIPVPTAATASSWAATVLLICAAAAAVVFLVSATRFSSTPAKVLGIVVAASAVIISIGYALVVGSALLQPNTDEPISPRYHPCEAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW25</accession>
    <name>A0A231GW25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40814">
        <property type="protein sequence ID" value="OXR40814"/>
        <property type="gene ID" value="B7C42_07098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="21144" checksum="1A9F1F6ED1C63345" modified="2017-10-25" version="1">MAFSKRSAIIQLVFPPSGRVSARTQVSTRTRRAAVARLRGASAGSVSGALSIAAHGWAAGGMPVQSSTLMLLVAASTAVGALVAGLTPLRTTAVGLVTALWGGQLIGHLVMSADMAQMHDMPLWTPAMLGAHLVGAVCAAVVILGAEAAYRIGTAVARVLPVPVNLPATDEPILPRSVHRDRVILRIFPTETFRTRGPPLPAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW35</accession>
    <name>A0A231GW35_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methanol dehydrogenase activator</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">act_3</name>
        <name evidence="2" type="ORF">B7C42_07259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777719.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40701">
        <property type="protein sequence ID" value="OXR40701"/>
        <property type="gene ID" value="B7C42_07259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="22852" checksum="E2E5EBDA84946BE2" modified="2017-10-25" version="1">MSEPGSHDFRTVGSETVYSGAIVALRRDQVEMPGGRVAEREVVEHHGAVAIVALDDDGAVVLINQYRHPVGRRLLELPAGLLDQAGEDPLAAARRELAEETGLAAREWSTLVDVVLSPGFTDEALRIYLATGLSDTDRPDPEHEEADLAVVRMPLQEAVTAALSGRIENATAVAGVLAAWAARANGTTLRPADAPWPGMPTRLLERKAAEQARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW40</accession>
    <name>A0A231GW40_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40816">
        <property type="protein sequence ID" value="OXR40816"/>
        <property type="gene ID" value="B7C42_07100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172429" evidence="1">
        <location>
            <begin position="27"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="22872" checksum="382A3F0B2699E8EE" modified="2017-10-25" version="1">MGIKNITATAVLVAAALGLSTATAGADPTDAGAVGFQATTTPTGTVISTDAGSLSADDGVFTVKAADGTVLAGTQLSFRVDDFVFPIEAQIHDRTATLTPKFDLAHAAYQPVAMPFEDSAPWKTPYDREQAAWSRMTSTLSAGASIGTLVGGIGGAGIGCVLGGIAGATIAAATIVGMFGPFVPAAVVGCLGGIVAIGALGTLAGQLLVTAPVAVLAAAQYFTTVNSPFPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW76</accession>
    <name>A0A231GW76_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoglycoside phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40856">
        <property type="protein sequence ID" value="OXR40856"/>
        <property type="gene ID" value="B7C42_06991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="56"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="38604" checksum="5A43654CF6D94499" modified="2017-10-25" version="1">MTRVPTEQLPSMLEPILQQRIPNAQGGQVRNWSASPRGLATETCLFDFDCPGTTHSLVFRRPPEVALFPDYDLLRQVLVMQRLAGSGIPIPTVRWLDRDGGALGGPYMVMDRIPGEAPSDYPSYHTAGNYFDADRDGRQRMWWGCVDTIADVHRLDPQTLKLDFLAFPEHGDEPVEQIVGYIDAALRWACAEPPPALRRGVEWLRANTYEPVHVTLCWGDARMSNILYDTNLRVTGVLDWEVAYLGDHEADLAWMLFLDWACSEYEGHEPLPGTPSREQTIEYYEHRSGMPVENLRFNEILAATLLSIPLLRMTDRLQLPPELDLTAFCAARIDQLLETAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWG8</accession>
    <name>A0A231GWG8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40973">
        <property type="protein sequence ID" value="OXR40973"/>
        <property type="gene ID" value="B7C42_06939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="31718" checksum="D7469F836ED97CD4" modified="2017-10-25" version="1">MASSALNHYRSPWTRTLDLDAGRRHLLDWWHGPDRIYRAGKAVHDHLAGAPASCAYAFTLFVTWWTLRGISDFAGHRLILSASTNLHNMRREPVQVLVASAFWTDGGFPWVIILGFLTVMAFAERWLGTLRWIMVFACGHVGASMIVVTGIAFAVHHDLIPLRIAVASDVGSSYGSTAVLAALSFHLRGTPRAVWAAGLLVWFGFAAWHGRTFTDYGHLTALCIGFAVGAVAVALSRRLERIRDQRPAGTRRRLPDDTAPGPIEPPAPAQALVRENRPSADGRSESTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWN5</accession>
    <name>A0A231GWN5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein LpqB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">lpqB</name>
        <name evidence="7" type="ORF">B7C42_06807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LpqB lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780321.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41037">
        <property type="protein sequence ID" value="OXR41037"/>
        <property type="gene ID" value="B7C42_06807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01373">
        <property type="entry name" value="LpqB_lipoprot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023959">
        <property type="entry name" value="Lipoprotein_LpqB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011237329" description="Lipoprotein LpqB" evidence="5">
        <location>
            <begin position="32"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="6">
        <location>
            <begin position="201"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="601" mass="63401" checksum="4E13DCED60B2C5A9" modified="2017-10-25" version="1">MNRTRLATLLAALFSCVLVLAGCANLPDSSAPQALGTLNHEPTSTGPHPPIVGRDPDLLLHDFLEATADPTDHHRTARQYLTPAAAQSWDDTASTVIVDKPDTLRESRSDNTATYQIRARKVGQLEADGAYSPVDNLLESKIEMTKVGGEWRIDDLPAGVAIDSNAFYKSYRRFTVNFANPEGTAMVPDLRWVSARKEQLTRVLLSLLSQGPQEALAPAVRNMLADPVTVRGISKANGDVEGVGVGLGGVRVDLTGTGGLDPHSRELLAAQVVLTLSSADILGPYFLFGDGKPLDERHAESGWSVADVGNYNVINRAHNKIGLHVVRDGALMKVTDTSVVPVPGYFGAARNLQSVGLSEDGKLVAAVADSGQPAPAPAQTLIIGSHDGTAFPVAQGNSFTRPSWAFDGGSAWVVVDGNRVIRAVHDQANGNVSVQDVDSSDLFAVAAASSSGSVPPRLPITELRISRTGARAAMIIGGKVYVAVVVPRGDGKFALTSPQPVAVSLSTPAVSADWLGADTLIVAREGSVDPVQSVVIDGSQPNPFTSRNLTTPVRVVSASPDEQYVADSRAVMQLQSVEPNTERFWREVQGLGANAIPVLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWQ7</accession>
    <name>A0A231GWQ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor NicR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nicR_2</name>
        <name evidence="2" type="ORF">B7C42_06840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41070">
        <property type="protein sequence ID" value="OXR41070"/>
        <property type="gene ID" value="B7C42_06840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="15353" checksum="6226BD9A32C0A869" modified="2017-10-25" version="1">MPEAPHIDTAQLMEVLSVSLGVYYSDFTAAAASENLTASQGKTLTVLRRGPAAMRTLAEILACDASNVTGIIDRLEKRGLVRREASASDRRVTNLVITSEGERAVDAIRATMHRTREGLSRLGDEDRARLSSLLERAFVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX61</accession>
    <name>A0A231GX61_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41155">
        <property type="protein sequence ID" value="OXR41155"/>
        <property type="gene ID" value="B7C42_06751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="22788" checksum="5287106369190748" modified="2017-10-25" version="1">MTESTPQPPAGPTPQPPAGPEHTWVPPQTQPAATWSTKKSLAAVGIAAVIAAAGGGVVYAATHSGGSEHGGPGGPGGPGTSWGGGRNASGPGGMGMTGASLHGQFVISDGNGGYTTEITQTGTVTAVSDTSITAKSADNFSQTYTISGSTQHSAVKVGDTVRIQGTEVNGTATATAITSGTESGRTDGRTGRSSRFGGMAQGGDPGQNGPGPGGAAPGQGGGPGMAPPMDGAPNQPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY74</accession>
    <name>A0A231GY74_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41574">
        <property type="protein sequence ID" value="OXR41574"/>
        <property type="gene ID" value="B7C42_06215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="27071" checksum="78FAD21DB022FD09" modified="2017-10-25" version="1">MVLPCGFRDEHGYGRDNPCDIEAEMPVLLDSTRAHQFPYQRVAWGHRPARTAQVGDVERFTHNGFPVLGIVSTARRLLILPIRAADQVELGEVDFAGNGRCSRVDGRDVPHQIVGAVPVQEKVVCAQVEVRQIAGDAQQCEVGESVTGQIDRPAVVVVHPVASGGFRVALGAQIDTTEGLRKRAVDGEDRFAVVEGQPRAGCAEPGCRRFARAHEPFGVDIVIDRQESGHVVRDFGPELLGSPYRPLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY92</accession>
    <name>A0A231GY92_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41587">
        <property type="protein sequence ID" value="OXR41587"/>
        <property type="gene ID" value="B7C42_06228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="178"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="28614" checksum="CAC0A7BF6D129E37" modified="2017-10-25" version="1">MCWSYTGIAEFRTRAAEFLADGLDAGCRVCYIRPGTVGDIAEDLRELAGWSEALRDGRAEVISLSELHDADAVLDPSGQVQAYAEATERAVADGFRGLRVAVDCTSLVNDAPRLAVFARFEHLIDRYMAGHPFSALCGYDRSAVEAEVLAELACLHPCTDARAAGFRLYAPLSAGHTVALAGELDLSTRDLLAPTLKRIDLKPEGGEVVLDASGVEFMDHVSVTRLADWAAARDADLVIRTQWSGIDRVIRLLDISNVRAEQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYQ6</accession>
    <name>A0A231GYQ6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">uvrD1_2</name>
        <name evidence="10" type="ORF">B7C42_06078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41736">
        <property type="protein sequence ID" value="OXR41736"/>
        <property type="gene ID" value="B7C42_06078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="356"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="849" mass="93175" checksum="398580EFBC98568A" modified="2017-10-25" version="1">METTVAGTAAGTATVGTAATRGADRSAQADQQAQRLLEGLNPQQRAAVVHAGSPLLIVAGAGSGKTAVLTRRIAYLLAERGVTPGQILAITFTNKAAAEMRERVTDLVGPRAAAMWVSTFHSSCVRILRMQANLLPGALNSNFSIYDADDSRRLLAMIIRDQNLDPKKYSPRLLATAISNLKNELIDPETATADAESDETELPGIVARVYTEYQRRLRAANAFDFDDLIGETVALLQSHPQVAEYYRRRFRHVLVDEYQDTNHAQYVLVRELVGHHVRPAADELDDADAGAEAADPEFSPARRGDAVPPSELCVVGDADQSIYAFRGATIRNIEEFERDFPDAETILLEQNYRSTQHILSAANALISRNENRRDKKLWTDSGEGDLIVGYVADNEHDEASFVAREIDRLVDQGDYNYGDVAVFYRTNNNSRALEEIFIRMGLPYKVVGGVRFYERKEVRDVVAYLRVLENPDDAVSLRRILNTPRRGIGDRAEACVAVHAEQRDIGFAAALRDAADGKVALLNTRAQRAIAGFLDLLDEIRAAGVTDDTEFPDVGNVVEAVLDKTGYRAELEASDDPQDGARLDNLNELVSVAREFSSEARNNVEAAREEGLLPEAADGEPDPGSLAAFLERVSLVADTDQIPDEGSGVVTLMTLHTAKGLEFPVVFVTGWEDGQFPHMRALGDPAELAEERRLAYVGITRARKRLYLSRAVVRSGWGQAVSNPESRFLQEIPGHLMDWQRLEPTPPSGGRGFRRRGEDDGLERDWTRGDGWSQQRPGLRDRSPARPAAKHNNSGLVLAVGDRVSDDKYGLGRVVAAEGFGALATVTIDFGTAGKIRLIPQYSRTLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZA2</accession>
    <name>A0A231GZA2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranial dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">geoB_4</name>
        <name evidence="5" type="ORF">B7C42_05886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.86" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41902">
        <property type="protein sequence ID" value="OXR41902"/>
        <property type="gene ID" value="B7C42_05886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="16"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="489" mass="51455" checksum="D40F7461C7D21135" modified="2017-10-25" version="1">MDTNQDRTSLFVDGRWAAPASGATVEVIEAATEKVLATAALAAPADIDAAVAAARGALASWRALDGAERADHLDRFAAALKARAKQTAVLASRENGMPIATSINVNGYAPALMIEYYARRIRDMERDELRPSAFGGRTVVRREPVGVVAAITAWNYPQSLAAMKLAPALAAGCTVVLKPAPETALDAYVFAEAAEEAGLPSGVVNIVPADREAGAYLVEHPGVDKVAFTGSTPAGRAIGEACGRLLRPVTLELGGKSAAIVTADADLTEFAAKLLEVSLVNNGQTCHASTRILAPRSRYTEVVEAVTETVRALRIGDPLDKTTQIGPLVSAAQRDRVLGYIESGRADGYRITTGGGTPDDQPVGWYVEPTVFDGVDNNARIAQEEIFGPVLTITPFDTEQDAIALANDSAYGLGGTVWTTDEERGLAIADRIESGTFGVNHYLLDLGAPFGGVKSSGLGRELGPEGLAPYLRTKSVYFGTSASTERSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B7</accession>
    <name>A0A231H0B7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_05488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42289">
        <property type="protein sequence ID" value="OXR42289"/>
        <property type="gene ID" value="B7C42_05488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="26322" checksum="F5DDB1E47DBA1E2B" modified="2017-10-25" version="1">MTGPTAHELLWGNPQRPRRGPKPSLSLERIVTEAIALADADGMAAVSMQRLAERLGCAKMALYRYVPGKAELTALMLDYGMGQPPQVAAAESDPEPWREALRQWAGTMYERYRAHPWTIELTAGARPLGPNELGWMEAALAPLAGTGLRGSERLDTVVLLNGHVRSLVQQTASSGPEQAESEMAKQVGEVLAAHADRYPEVVAAFADTSADGRNAALSYGIERILDGVAALIARRRDRKPSNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0E6</accession>
    <name>A0A231H0E6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780607.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42292">
        <property type="protein sequence ID" value="OXR42292"/>
        <property type="gene ID" value="B7C42_05491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013207">
        <property type="entry name" value="LGFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08310">
        <property type="entry name" value="LGFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011235761" evidence="2">
        <location>
            <begin position="28"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="20323" checksum="B077DC8DE1E0690E" modified="2017-10-25" version="1">MHHFARRSAAVVMAFAGTALLFTAACSNDNSDNSSSGTTTTHAGMGETTGAMATGTTATMATGTPSPGETSPGNPAATETKIATQNGQEVAVSGHILTKYTEMGAVQSPLGEPTGAAVEGPNGGSCQEFTGGAICWSQQTDAHVVWGDIRTAWEGNGGVNGKLGYPTSDEKDNPTGKESDFTGGTITWNSADRQTTVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0K3</accession>
    <name>A0A231H0K3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine N-alpha-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Histidine trimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">egtD</name>
        <name evidence="5" type="ORF">B7C42_05601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:38471"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. EgtD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42400">
        <property type="protein sequence ID" value="OXR42400"/>
        <property type="gene ID" value="B7C42_05601"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030745">
        <property type="term" value="F:dimethylhistidine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02037">
        <property type="entry name" value="EgtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032888">
        <property type="entry name" value="EgtD_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="4">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-histidine binding" evidence="3">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="35343" checksum="9E126F2FA1A1D0CA" modified="2017-10-25" version="1">MSEPTLDIHLTDDDLDAALRSDARTGLTADPKTLPPKWFYDARGSELFEAITELPEYYPTRTERALLERVVGDIARTAQAEVLVELGAGSAAKTRLLLSALLAEGPLKTYVPQDVSVSALRGAAEQIGTEFPNLAVHGVVSDFTETLHNLPRGGRRMIAFLGGTIGNLVPQERAEFLAGIQQVLEPGEQLLLGAGLVTDPAVLVPAYDDAAGVTAEFNRNVLHVLNSRLHADFDPDAFAHIAHWDAENEWIEMRLAATRDMTVTVADLDLVVDFAQGEQMRTEISAKFRVDGLGRELDSAGFTTEEVWTDPDERFVLVLAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0S0</accession>
    <name>A0A231H0S0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42449">
        <property type="protein sequence ID" value="OXR42449"/>
        <property type="gene ID" value="B7C42_05651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024414">
        <property type="entry name" value="Uncharacterised_PrgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12666">
        <property type="entry name" value="PrgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="3">
        <location>
            <begin position="610"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="3">
        <location>
            <begin position="832"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1013" mass="106265" checksum="1AEA02C90C30ECE7" modified="2017-10-25" version="1">MNSYRIPSDVERPDRIVGPFTARQLGLLAGTGLVLLLAWAATRALVPITLFAGFAAPIAAVATAIVLTTRDGLSGDQLLLAALRHLGRDRHLIAAHPGDEHNGTPPRWLTDRAHGPLPPAAHPITCDTTALPRSISAGSGGLGVVDLGEEGIAVIAAATTINLALRTPGEQAGLVAALGNYLQSLSGGVQILLRSVRQDVTGRISDLRLAAQEMSPELADYARDHARHLAELADDDTAAQRQVLLIWREPLDPVTRLAASVLGGLTARGRDERRIAAHARHAAQTRLAARVTDATDMLAPLGIGVRALDEDAATAILTSCANPANLVPFGAAEAAGPTEIITTGASEYAGMHFDATLTADDEDETETPRGGRRLFGSRAGRRGARVQFAPESLTIGARHLQVGSDFIATIAVTGYPREVSPGWLAPLAAFGGRVDIALHIEPIDPRLAALRLRRQLARLESSQASAAVNGRVGDPAVDVAAEDAAALSAQLARGESRLFRAGLYLTVHASNEDDLAAQVSALRTLAASLLIDTCPTSYRAVQGWTATLPLGLDPVRVHRTFDSHALAAAVPFASAQLPPADPVSLTPAGALYGRDGAAGLLFHDRFGPAMHNHNEVILGRSGSGKSYLAKTSILRSLYRGIETLVIDPEDEYAVLCDALGGTHIRLGAPGVCLNPFDLDIHYGPSGHRTAPADALTRRKLYLHTVIAVLLGEQTPAQRAALDTAVTATYAAAGITDDPATWTRPAPTLNLLRDQLAATGGPVADDLAAGLAPYVDSGAFAGLLDGASSHDPSGALTVYSLRDLPEELRTIGTLLALDATWRRVSDPGLRRPRSVVVDEAWLLMRQRAGAEFLARLAKSARKYFAGLTVATQDAADVLATDLGKAIVANSATQVLLRQAPQAIDQVGDAFALSEGERRFLLAADRGQGLICTGVHQRTVFAAVASAAEHQLATTSPEYDLYDTDETGYDDVAPDTVGTEIDLGPDEFDPGAGDAYAGPDPARDLGPDEADKGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0X0</accession>
    <name>A0A231H0X0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">nuoB</name>
        <name evidence="4" type="ORF">B7C42_05275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514408.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42499">
        <property type="protein sequence ID" value="OXR42499"/>
        <property type="gene ID" value="B7C42_05275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="20013" checksum="00EEF1936EAA6543" modified="2017-10-25" version="1">MGLEEKLPSGFLLSTVEQFAGYLRKGSLWPATFGLACCAIEMMATGAGRFDSARFGMEVFRASPRQADLMIVAGRVSQKMAPVLRQVYDQMTEPKWVLAMGVCASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQEMPLGVDRAEAVRAAEAAALASTPTIRMEGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H100</accession>
    <name>A0A231H100_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase</fullName>
            <shortName evidence="8">DHK-MTPene dioxygenase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="8">ARD'</shortName>
            <shortName evidence="8">Fe-ARD</shortName>
            <ecNumber evidence="8">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="8">ARD</shortName>
            <shortName evidence="8">Ni-ARD</shortName>
            <ecNumber evidence="8">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">mtnD</name>
        <name evidence="9" type="ORF">B7C42_05321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 1 Fe(2+) cation per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="8"/>
    <dbReference type="EC" id="1.13.11.53" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777334.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42544">
        <property type="protein sequence ID" value="OXR42544"/>
        <property type="gene ID" value="B7C42_05321"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01682">
        <property type="entry name" value="Salvage_MtnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023956">
        <property type="entry name" value="ARD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="PTHR23418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 8 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="1 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in metal incorporation in vivo" evidence="8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in transmitting local conformational changes" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="site" description="Important to generate the dianion" evidence="8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="21255" checksum="6F6DAA08941FB81A" modified="2017-10-25" version="1">MTLLHIAADTDPADVRLHTTDPERIAAELATRGIVFDRWPAEAVTADIASEEILARYRDRIGDLNADGRYRHIDLARLHPDDSDPQWPEQASAARQKFLSEHRHAEDEVRFFVSGRGCFYLHLEPEVVAVVCEGGDLVSVPAGTRHWFDMGTRPDFVAIRFFEEADGWIGDFTGDPIAQGFPTLDELVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1L7</accession>
    <name>A0A231H1L7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">clpC</name>
        <name evidence="14" type="ORF">B7C42_05073</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42736">
        <property type="protein sequence ID" value="OXR42736"/>
        <property type="gene ID" value="B7C42_05073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="813"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="430"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR42736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="849" mass="92193" checksum="5704AB7ABA01DA72" modified="2017-10-25" version="1">MTAAWPSSFNSFDDLFNRFFGPGMAAQPPVQRIDLGRLLSDSAKELIAIARSTAQDWGNPEVTAEHLLYAATQVEPSRGIIGQLGLDPDKVAAQMRGAAGSGEATATAGGQVVLGPGAKLALRTAQRNAAEAGSSYIGPEHILLGIADNPESPAAQSLSGAKLPAAEGQKKPTDTPTLDEYGRDLTAEARAGKVDPVVGRAEEIEQTVEILSRRCKNNPVLIGDPGVGKTAIVEGLAQRIVNGDVPSTLADRRVVALDVGSLVAGSKYRGEFEERLTKILDEVREHSDELVLFIDELHTIVGAGTGGEGSMDAGNLLKPALARGELHAIGATTVDEYRRYIEKDAALERRFQPVLVPEPSVADTIEILRGLSDVYEEHHQVHYEDEALVAAAELSDRYITDRFMPDKAIDLIDQAGARVRLRTRMPGPDLRAAREELSRLEREKDAAVAGEDYARADELKGEISAAEERVGHITADEAPTVTLDDIAEVVSKQTGIPVSELTVEERQRLLQLEDVLHKRVIGQDEAIVAVAEAVRRARAGMKDPNRPIGSFLFLGPTGVGKTELAKALAEAVFGDEDRLIRFDMSEFQEKHTVSRLVGAPPGYVGYEDAAQLTDKVRRQPYSVILFDEVEKAHPDVFNVLLQLLDDGRVTDAKGRTVDFKNTIVIMTSNIGSDLILKATSAELDAITPRLMERLQQHFRPEFLNRIDETIVFHRLDQEQLRRIVDLVLDGPRRRLRAQHIELDVTDAARDWLSENGYQPEFGARPLRRTVQKQLENQVSRLVLGGELNPGDTVRVDADESGLIVAVVAGSGAERSLDASANGQKPKGKKANGKSDAKSEKKSGAKSGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1U9</accession>
    <name>A0A231H1U9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ECF RNA polymerase sigma factor SigI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sigI_4</name>
        <name evidence="7" type="ORF">B7C42_05150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42812">
        <property type="protein sequence ID" value="OXR42812"/>
        <property type="gene ID" value="B7C42_05150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="439" mass="47928" checksum="69828AACD36D041C" modified="2017-10-25" version="1">MLDDHSPGPARLDRSTDRVAAAVADAHRREWAFVLAATVRVTHDLELAEECVQDAYAQALVRWAADGIPSRPAAWLTTVARNRALDLLRRQSTARRALPLLIADETTTGTTDFDAIDPYDPQFPDDRLRLICTCCHPALAPQTQVALTLRLVCGLTTAEVARAFLVAEPTMAARITRAKKKIAAARIPYRVPGPAELPERIEAVLAVVHLLFTTGHTAPSGDDLIRRDLTERALDLARMLHGLLPEDPEIAGLLALLLLTDARRAARVTAGGAMVALADQDRARWDREEITQGIALVRFALERRPGRYALQAAIAAVHAEAPSYAATDWQEIRGLYDVLIRIWPSPVVALNRAVAIGMAGDPAAGYAALDTLAAEPQLAGYSYLPAARAHFLTALGRFDEARLAYSEALLLTENAAERDFLDRRLAELDRRASGRHNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Y2</accession>
    <name>A0A231H1Y2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42851">
        <property type="protein sequence ID" value="OXR42851"/>
        <property type="gene ID" value="B7C42_05189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16551" checksum="40BA669240BC1412" modified="2017-10-25" version="1">MATIRHEIAIDAPPQHIWDVLRDIGAVHERLLPGRVADTTLDGEHRILTFPDGHRIRERIVSVDDDLRRLAYSVIEGARPALTHHHASFEVRETDSRTGRLIWTTDLLPDERASEVRIRIEYGAAEMKRAIEAAAVPGASPGAAGVSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H261</accession>
    <name>A0A231H261_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anhydrotetracycline monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">otcC_3</name>
        <name evidence="2" type="ORF">B7C42_04819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.38" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778369.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42933">
        <property type="protein sequence ID" value="OXR42933"/>
        <property type="gene ID" value="B7C42_04819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047670">
        <property type="term" value="F:anhydrotetracycline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="533" mass="56352" checksum="27E4A5F1DC1D3F63" modified="2017-10-25" version="1">MSENTYDVLISGAGPNGLMLACELALSGVTALVLEKLPAPSTEPKANGLVGQVVRLLDMRGLYRRAAGADAPAIPPPLPGYSFSGLPLDLAEFADNPLYALPIPQPRLVALLAARARELDVAVRWGHALRDLETHRDHVVATVDSPSGAYRIPARYLVAADGGKSAVRKLVGIDFPGCTVVDRVTRFGHATVPDGLRTPDGGIDIPGAGRFHFGHNRVDKGMFIFAELTPGRPMIGVSEYGTDHLPAEDEPVTFAELRASIERVLGAEVPIEPPTGAGPHALRRTVGQNTRLAERYREGRVLLLGDSAHVHSAMGGPGLNLGLQDAINLGWKLASEVNGWAPAGLLDTYESERYPAAERVMMHSLAQSALIAPGPEVTGLRDLFAELVRIPAVADHLAHLLAGADIRYDVGDDHRLSGQLVPDYTVTTDGTRVRVADLLRTARPLLIDSTGVAAAAAANWCARVEIISGAITLTERGRPVGTAAESGTASPPTAILLRPDGYVAWAGDDASADGLHSALTRWFGSSPVPVHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2I5</accession>
    <name>A0A231H2I5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1992 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43063">
        <property type="protein sequence ID" value="OXR43063"/>
        <property type="gene ID" value="B7C42_04949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DUF1992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1992" evidence="2">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="20193" checksum="C26D6274D543D000" modified="2017-10-25" version="1">MTERKPAGMGFESWIDKQIREATERGEFDNLAGTGKPLPGMGEPYDENWWLHNYLRREGVGGEALLPTSLTLRRDLERLPERVAEMGSEAEVRAYVSELNMRIVEWIRMPHGPHVRLAPARADEVVARWRADRRIRQRPISGSGKPSPATTSTRFRDSRPPWWRRLLRRDRPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2J2</accession>
    <name>A0A231H2J2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ethanolamine ammonia-lyase large subunit</fullName>
            <shortName evidence="1">EAL large subunit</shortName>
            <ecNumber evidence="1">4.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">eutB</name>
        <name evidence="2" type="ORF">B7C42_04948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ethanolamine = acetaldehyde + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15313"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="4.3.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
        <text evidence="1">Binds between the large and small subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine degradation; ethanolamine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EutB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.7" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43062">
        <property type="protein sequence ID" value="OXR43062"/>
        <property type="gene ID" value="B7C42_04948"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008851">
        <property type="term" value="F:ethanolamine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00861">
        <property type="entry name" value="EutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010628">
        <property type="entry name" value="EutB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044939">
        <property type="entry name" value="EutB_dom_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044941">
        <property type="entry name" value="EutB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39329">
        <property type="entry name" value="PTHR39329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06751">
        <property type="entry name" value="EutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018788">
        <property type="entry name" value="EutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="473" mass="49489" checksum="B6B51E1EDA361535" modified="2017-10-25" version="1">MTRYQQTLHGRTYAFGGLVDLLAKATPLRSGDELAGCAASSDAERAAAQRALAEVPLREFLNDPVVPYETDEITRLILDNHDRDAFATIAHLSVGGLRDWLLAVAAGSEPEPPAAVLRSVAAGLTPEMVAAVSKLMRNQDLIAVARAAEVRSGFRTTIGLPGRLATRLQPNHPTDDPRGIAAAVLDGLLLGCGDAVIGVNPATDSPRAAAELLTLLDDVRTRFDIPVQSCVLAHVTTTLGLIEAGAPVDLVFQSVAGTEAANASFGVNLSLLREANAAGRSLGRGTVGDNVMYLETGQGSALSAGAHLGTGGRPVDQQTLEARAYAVARELEPLLVNTVVGFIGPEYLYDGKQIVRAGLEDHFCGKLLGLPMGVDVCYTNHAEADQDDMDTLLTLLGAAGVAFVIAVPGADDVMLGYQSLSFHDALYVRRLLGLAPAPEFEQWLAGLGMLDAAGGIAAVEPLSSPLRELAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H334</accession>
    <name>A0A231H334_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="2">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fadI_3</name>
        <name evidence="2" type="ORF">B7C42_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43228">
        <property type="protein sequence ID" value="OXR43228"/>
        <property type="gene ID" value="B7C42_04650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_C" evidence="1">
        <location>
            <begin position="247"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="383" mass="40123" checksum="42E7345C3E91CF7E" modified="2017-10-25" version="1">MNRKVAIAGVALSDVGRVEDKNAYELMAQASARALAETGLTPQDIDGLCSTGQGMLPPTDVGEYLGLRPRWIDSTSVGGASWEVMVSHAADAIAAGHADVVLLTYGSTARADLRKGLRTANINWGARGPLQWDAPYGHTLVSKYAMAARRHMFQYGTTIEQLAEVAVSARFNAADNPEAYYRDPISVEDVLSGPMIADPFTKLHCCIRSDGGAAAILVAEDRVPDLKSDPVWVLGSAEATSHMLTSQWEDMTIGPAAVTGPLAFRRAGLTPADVDVAELYDAFTYMLLLTLEDLGFCGKGEGGAFAESGALRLGGALPTNTDGGGLSACHPGQRGLFLLVEATRQLRGAAGPRQVPGAEIACVSGTGGWFCSSGTVLLGANKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3L2</accession>
    <name>A0A231H3L2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43372">
        <property type="protein sequence ID" value="OXR43372"/>
        <property type="gene ID" value="B7C42_04239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="21705" checksum="137E9C2D27FD69A0" modified="2017-10-25" version="1">MNITTAQSTIASVVVETPDPAAAAAFYESAFGLGDRLRVRRSDAETTGFRGYILSLVVSQPSTVDSFIGSAVAAGATTVKPAKKSFWGYGGVVQAPDGAVWKIATSAKKDTGPASREVDDFVLLLGVDSVKATKQFYVERGLTVAKSFGGKYAEFESPAGSVKLALYGRKAAAKDAGVPAEGSGSHRIAITSPLGSFTDPDGFAWEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3L6</accession>
    <name>A0A231H3L6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43447">
        <property type="protein sequence ID" value="OXR43447"/>
        <property type="gene ID" value="B7C42_04314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="45" mass="4725" checksum="DB5B48B92A53A3B0" modified="2017-10-25" version="1">MTWTTDPEETAAVDAMRAAVRAMADLLTTVDAARWADPAGGFGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H439</accession>
    <name>A0A231H439_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">uvrC</name>
        <name evidence="10" type="ORF">B7C42_04466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43598">
        <property type="protein sequence ID" value="OXR43598"/>
        <property type="gene ID" value="B7C42_04466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="259"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="706" mass="77280" checksum="13F5AE526E54C26F" modified="2017-10-25" version="1">MADPATYRPAPGTIPVEPGVYKFRDSYGQVIYVGKAKSLRSRLNSYFADVSSLHPRTRQMVTTAASVEWTVVSTEVEALQLEYNWIKEFDPRFNVRYRDDKTYPMLAVSMNEEYPRVFVYRGARKKGVRYFGPYAHAWAIRETVDLLLRVFPVRTCSAGVFKRHRQIGRPCLLGYIDKCSAPCIGRVDAAEHRRIAEDFCDFLSGRTDRMVRELERRMQSAAADLDFETAARLRDDVAALKRALEKQAVVLGTGTDADVIAFASDELEVAVQIFHVRDGRVRGQRGWVVDKSGDAVDLNWAGTEDAAGAAPIDEGGRGPSELAALVEQFVTQFYGEQAAFAEHTDTETPATAVPREVLVPELPGDPEQVQGWLSGLRGSAVALRVPQRGDKKALMETVQRNAQEALAQHKLKRAGDLTARSAALQGIQDALDLDSAPLRIECVDISHVQGTDVVASLVVFEDGLPRKSEYRHYTIKEAAGEGRSDDVASIAEVTRRRFYRLRKELDEMSAAAKADAGAAHYGDGTDASQHRAGAAAIATAEAEPADLPPGIDPATGRPRKFSYPPNLYVVDGGAPQVAAAAEVLDELGITDVAVIGLAKRLEEVWVPGESDPVIMPRTSESLFLLQRVRDEAHRFAITFHRSKRSRRMTASALDSVRGLGEARRTALVTHFGSVAKLKQATVEEITEVPGIGVATAKAVLAALNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4E1</accession>
    <name>A0A231H4E1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43698">
        <property type="protein sequence ID" value="OXR43698"/>
        <property type="gene ID" value="B7C42_03933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="48"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="20148" checksum="241FE1D8CF11A691" modified="2017-10-25" version="1">MVSTEPRIAPGRLRELGPVNWVVWQVLSRAAGTDDAHLFSTLGRTGGLFRGWLHFSGRLMPGGKLSRYETELVILRVAHLRNCEYETDHHIRLGKRAGVTKDILARLRTGPDAEGWPDKERALLTAVDQLVTTRDVDDATWSALAQHYDEKRLIEIVLLANQYEGLASTITTLRIQTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4G5</accession>
    <name>A0A231H4G5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43682">
        <property type="protein sequence ID" value="OXR43682"/>
        <property type="gene ID" value="B7C42_03917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="12989" checksum="19CC27955BDF457C" modified="2017-10-25" version="1">MLNQTERLDLIFRALTDPTRRYLLERLGRGPAAVSALAEPLEMSLAAVVQHLQVLQDAGLVRSEKVGRVRTCHLVPDALRPAEDWLHARQTPWERRLDALGAALAEHTIPEPEESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4G6</accession>
    <name>A0A231H4G6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43751">
        <property type="protein sequence ID" value="OXR43751"/>
        <property type="gene ID" value="B7C42_03986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="29106" checksum="E9B1ED735FD9B761" modified="2017-10-25" version="1">MRPHARTAPVGAITRGTTGINRLRRSDRWLIHDPLVVRRLRSAADPLVVDLGYGASPVTTLELAARLRRVRGDMRVVGLEIDPARVVPDRDGVRFARGGFELAGLRPVLVRAFNVLRQYDESEVAGAWATILGGSAPEGLLLEGTCDELGRRCAWILLDREGPISLTLAWDPFTVDKPSDIAERLPKALIHRNIPGERVHTLLTAADRAWSHAAPMAVYGPRVRWRAAAQLLREQGFPVRNYRRRMRDCVLSVPWECVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4P8</accession>
    <name>A0A231H4P8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hemL_1</name>
        <name evidence="7" type="synonym">hemL</name>
        <name evidence="10" type="ORF">B7C42_04033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43798">
        <property type="protein sequence ID" value="OXR43798"/>
        <property type="gene ID" value="B7C42_04033"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011246822" description="Glutamate-1-semialdehyde 2,1-aminomutase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="473" mass="48317" checksum="2C31CFAF5CB688E1" modified="2017-10-25" version="1">MRRPVLWGGSPHYTLSSTAPAGAATLVVVSSSPRATQVNVPVSARLFERAAAIIPGGVNSPVRAFNSVGGTPRFIASARGYTLTDADGNDYVDLVCSWGPMILGHAHPAVVDAVQRAATGGLSFGAPTEAEIELAEAIAARVDPVQRVRLVNSGTEATMSAVRLARGFTGRSKIVKFAGCYHGHVDALLADAGSGVATLGLPTSPGVTGAQASDTLVLPYNDLEAVATAFAEYPGQIAAVITEAAAGNMGAVPPLPGFNAGLRELTSEHGALLIMDEVMTGFRVSAAGWYGRDPVAGDLYTFGKVMSGGLPAAAFGGRAEVMDHLAPIGPVYQAGTLSGNPVAVAAGLATLRAADADVYAALDRNAERLGSLITEALTTAGVPHTVQFAGNMVSVFFAEGPVTDYATAKATATWRFPAFFHALLERGVYAPPSPFEAWFVSAALDEDAFDRIAAALPAAAAAAAAATPEGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4U1</accession>
    <name>A0A231H4U1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43838">
        <property type="protein sequence ID" value="OXR43838"/>
        <property type="gene ID" value="B7C42_04073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_9" evidence="2">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="SIP" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8251" checksum="018C4F1EDDE8EB3A" modified="2017-10-25" version="1">MREFRPAGQGEFGETAELDIDFAMHGGHTPACGWAANTTPGTALATSLRRHLANERGIAKADITFTGYWRFGKSAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5B4</accession>
    <name>A0A231H5B4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cobS_1</name>
        <name evidence="19" type="synonym">cobS</name>
        <name evidence="20" type="ORF">B7C42_03617</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042240.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44061">
        <property type="protein sequence ID" value="OXR44061"/>
        <property type="gene ID" value="B7C42_03617"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXR44061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="25441" checksum="F28B1587FD9F1136" modified="2017-10-25" version="1">MLWHRRIGVPAVIAAARLALSWLTVLPVRGPETVDRRAAAGAIAAAPVVGAVLGAGAAGLLWVLIRVGTGFALAGLIIVGALGLATRGMHLDGLADTADGLGSYGPPERAREIMKSGGAGPFGVAALIFAIGVQALSFAALAEHGRWFAVGLAVAVGRVAVVLACRGYASAPGAGFGALVARTQSAVTPAVWTLAALVAGVFAAPASWLGPVAVAVALAGAAVLVWHCVRRFGGLNGDVLGAAAEVTVAVTAAVLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5G1</accession>
    <name>A0A231H5G1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plsC_4</name>
        <name evidence="2" type="ORF">B7C42_03660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514742.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44104">
        <property type="protein sequence ID" value="OXR44104"/>
        <property type="gene ID" value="B7C42_03660"/>
    </dbReference>
    <dbReference type="GeneID" id="66721664"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="26805" checksum="39DCFF5096D2D491" modified="2017-10-25" version="1">MFYWLLKFVLVGPFMHIYNRPKVEGVENIPADGAVILAGNHLSFTDWLFTPLLSPRRITYLAKAEYFTTPGLKGRLQKFFFSGTGQYPIDRSGASAAEDALNTARKLLSEGRMVGLYPEGTRSPDGRLYKGKTGVARLALETGVPVIPVALIGTDEVCPPGPFRWRRRRVTVKFGAPIDFSRYEGMGGNRFVERAVTDEIMYELMRMSGQEYVDVYAASLKKGVPSGSRPEAERIPETLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5U8</accession>
    <name>A0A231H5U8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 16" type="primary">polA</name>
        <name evidence="16" type="ORF">B7C42_03792</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44231">
        <property type="protein sequence ID" value="OXR44231"/>
        <property type="gene ID" value="B7C42_03792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="14">
        <location>
            <begin position="45"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="13">
        <location>
            <begin position="345"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="15">
        <location>
            <begin position="692"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="936" mass="102133" checksum="D64D5E9B9DCF7AD3" modified="2017-10-25" version="1">MSVLVPRLCAVTPASTDQRQGSVSSTTAAAAAPKAGSTAAGAPGERPTLLLLDGHSLAYRAFYALPAENFKTVTGQTTNAVYGFTAMLINLLRDERPTHVAAAFDVSRKTFRVEAYPEYKANRISTPDEFRGQVEITQEVLGALGIPVMAIEGYEADDIIATLATQAVPQGFRVLIVTGDRDSLQLVNPDVTVLYPKKGVSELTRFTPEAVEEKYGLTPAQYPDFAALRGDPSDNLPGIPGVGEKTATKWIREFGDLPGLVERVDEVRGKVGDALRANLSSVVLNRQLTEMVKDVPLPYTPEQLAQQPWDRDKIHRLFDDLEFRVLRDRLFETLAPPEPEAESGFEISGGPVAPGAAADWLAEHAKAGARHGVSIVGTTTPVQGDVKAIAIAAADGEGGYFDVVALTPEDELAIGRWLADAETPKAVHEAKAAIHALRGRGWRLAGLTSDTALAAYLVRPGQRTFNLDDLSLRYLSRELRVEAAEDAQLSLLDDEDQVDTELAQAEILRARAVADLAEAFDTELDRIESVPLLTEMELPLLGVLAELEHAGIAVDCDKLDELQREFADRVASAAEAAYEVIGKQINLGSPKQLQVVLFDELDMPKTKRTKTGYTTDADALESLFEKTQHPFLEHLLAHRDATRLKVTVDGLLKSVADDGRIHTTFNQTIAATGRLSSTEPNLQNIPIRTDTGRRIRDTFVVGPGYESLMTADYSQIEMRIMAHLSKDAGLIEAFNSGEDLHSFVASKAFDIPIADVHPEMRRRIKAMSYGLAYGLSAYGLSQQLRISAEEAKAQMEVYFSRFGAIRDYLRDAVDQARKVGYTETLFGRRRYLPDLDSSNRQRREAAERMALNAPIQGTAADIIKVAMINTQAAIAEAGLRSRMLLQIHDELVFEVAAGEREALESLAREQMSSAIDLSVPLEVSVGVGRSWDSAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H609</accession>
    <name>A0A231H609_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44136">
        <property type="protein sequence ID" value="OXR44136"/>
        <property type="gene ID" value="B7C42_03694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="5">
        <location>
            <begin position="30"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="27350" checksum="22E499E9607F0B19" modified="2017-10-25" version="1">MNHAESGLGTTESEQGAPQSRAAGLAAALTRLEDRIDAACRAAGRERDTVRLLPVTKYFPASDVEILYRLGRREFGESREQEASAKVASLGHLAQMRWHMIGRLQRNKAKSVVRWADTVHSVDSERLVRALDTATAAARAEGARADPLRVLLQVSLDRDPARGGVVPDDLPMLADQVAKSENLQLAGLMAIPPLGAEPDAAFDELAGLHRTLLAAHPGATELSAGMSGDLEVAIRHGSTCVRVGTALMGERPITSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H618</accession>
    <name>A0A231H618_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpmI</name>
        <name evidence="7" type="ORF">B7C42_03831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518931.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44270">
        <property type="protein sequence ID" value="OXR44270"/>
        <property type="gene ID" value="B7C42_03831"/>
    </dbReference>
    <dbReference type="GeneID" id="66721505"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="64" mass="7361" checksum="4F8FF72F87CABF32" modified="2017-10-25" version="1">MPKMKSHSGTSKRFKVSGRGKLLRQQANRRHLLEHKSSRRTRRLDGTEVVAPADVRRVKKLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6H9</accession>
    <name>A0A231H6H9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclohexane-1-carbonyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="8">1.3.8.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_03244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.11" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44455">
        <property type="protein sequence ID" value="OXR44455"/>
        <property type="gene ID" value="B7C42_03244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="204"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="392"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="484"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="590"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="737" mass="76773" checksum="5E588EEC315BB0E1" modified="2017-10-25" version="1">MTIATTDEHKAVQESMRGWAAAVHPIATMRTGAPGYWREFWPGLVGLGVFRVAVPEEAGGAGGCVSDLAVLIEQAAHDLVGGPVTATALAGLVAGDTLDEDTPCGIALGRPVVLSHNATDALEVTGTWETVLGADEQTALLLPVRSGERELWCLLPAGTPGVTVEALEPLDPSTPLARVTCANVAVPGDHVFEPPYAVGDLVAALIAAEAAGIAGWCLETAVDYAKVREQFGRKIGEFQAIKHICAWMLCRTEQTRAVAADAAAAADLATAAAAADLATAAADASDSGRRELRLAAAVAMTIALEAAVENAKDCIQVLGGIGFTWEHDAHLYLRRATALRALLGGSAHWRAEVAKLTQAGVRRTVSVDLGDAEGGTAWEAAGLDAAEATVLAADLTRIAALPAAEQRAALADAGLLACHWPAPYGRDAGPIQRSLIEDQIRKAGIELPDLVIANWAIPTLLQWGTPEQIERFAPPTLTGEVIWCQLFSEPGAGSDLAALRTVAERVEGGWKLRGQKVWTSLADRATWGICLARTDSAAPKHKGISYFLVDMKSPGLEIRPLVEITGEARFNEVFLDDVFVPDDCLVGELGNGWRIARSTLSAERVAMGGKGIGEELEAVIAAAPTAGPGAEVVADRLGALIAESVAGTLLEARAAKKLLSGGDPAAESSVRKLVGVRHRQAVAEFAAELAGTAGALDTGVVKEFLLTRCLSIAGGTEQILLTVAGERILGLPRESKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7M0</accession>
    <name>A0A231H7M0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44849">
        <property type="protein sequence ID" value="OXR44849"/>
        <property type="gene ID" value="B7C42_02803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="32640" checksum="2080D3813F6926F6" modified="2017-10-25" version="1">MLAIGFEEPGGPEVLKPVEVAEPHAGPGEVRIRVAAAAVNPSDTVTRSGMAHDRYREVTPPYVPGWDAAGIVDEADPETGWRSGDRVVAITLPVLAGGGAYAEKIVVPASQVARLPEGSDFVSAATLPMNGLTAWFALDALDPRAGRTIAVTGAAGAVGGYVIQLAKTRGYTVIADAKPDDEQLVRDFGADVVLPRGEDLASRIRAHAPDGVDALIDTALQGDAVLAAVRDGGAFVLLRPAALGGGATPERGISVHLVMVADHLDEPHALSELSHLAAEGALTLRVARTFPAEHAARAHELLEAGGVRGRLVLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7M4</accession>
    <name>A0A231H7M4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nodulation protein NolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nolA_1</name>
        <name evidence="2" type="ORF">B7C42_02891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44934">
        <property type="protein sequence ID" value="OXR44934"/>
        <property type="gene ID" value="B7C42_02891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="32089" checksum="1B692467693F29D5" modified="2017-10-25" version="1">MTIGELSVRTGVPVRTIRFYCDEGVLEARRSAAGHRLFDPATAVDRLQLVRRLRALGLGLPAIMGVLTGTTSITDAVAIEKASLDTELAALTWRRAALAAVANTSPAQRAARLELLAAVGDRRRAYDELVAFWRRLLTPITPELFDAFVTMNVPAPPADPTPRQVVAYAELAIAATDPVLTAALAKQLWRHDPAHVRDKRALLAGIAEACAIVDPLVADHVEPRPGAELDRFLAAHAAARRVRPTAEFRRRLLYGADDNHPRIRRYWTLTTQITGTTTTGAAQDWLYRALSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H846</accession>
    <name>A0A231H846_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44970">
        <property type="protein sequence ID" value="OXR44970"/>
        <property type="gene ID" value="B7C42_02927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="137"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="359" mass="38227" checksum="F8543A10144BF700" modified="2017-10-25" version="1">MIRVIQWATGGVGRAAIEGVLDHPELELVGAWVHSPDKDGVDLGVLVGREPVGVTATTDAEALLALDADCVVYSPVFADTSVLRAILRSGKNVVTPLGWFYPRQRDREKFDAVCAEGGVTLHGTGIHPGGLTERLPLVVSALSGSVTGIRAEEFSDIRTYGAPDVVRHWMMFGADPDKAAQSTVAAMLAGGYSQSVWMLADELGFDLDPDIRTTHDVAVATAPIDSPIGIIEPGQVAAQHFRWEGTVDGEPVITAAVNWFMGERDFDPAWSFGPNGQRFEVEVRGDPGCVLTLSGLHAHDPAEGARRNPSIVATALNCVNAIPDVVAAEPGVRTYLDLPLPAGRAAPHLHRDRRTEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8A8</accession>
    <name>A0A231H8A8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
            <ecNumber evidence="2">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505766.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45075">
        <property type="protein sequence ID" value="OXR45075"/>
        <property type="gene ID" value="B7C42_03032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14139" checksum="92A9183A75697903" modified="2017-10-25" version="1">MIDTEGTRLFHSTMPFTEKLGVEVLEHGPKLVRSRLAWDESLCTLGGALHGGVLMSLADATGAVCAYLNLPEGKQGTTTVESKTNFLRAVRSGYAVASSTPLHAGRSFIVVETEIHDDAGKLVGKVTQTQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8J3</accession>
    <name>A0A231H8J3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_7</name>
        <name evidence="2" type="ORF">B7C42_03116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45158">
        <property type="protein sequence ID" value="OXR45158"/>
        <property type="gene ID" value="B7C42_03116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="30501" checksum="3682A8A7D03D4377" modified="2017-10-25" version="1">MTSTPSKYTPLPMLRAFRPLARGVVHSFRELGRVTIFVGKTFYLLPKTLMLYRQQTFKTMNSMAWGRGSLIVDGGVVGLMMLLGVSVGIAIAVQAYDALNLLGFGALSGIIGSFANIREIAPLLTGIGFAAQAGCRMTAEIGAMRISEEIDATEALGLQAIPFVVGTRLVGSMLCVIPAYLLALVVSFLTGGTIIKVFRGEAPGTYDHYFAQFLSPAEVGLSLAKAVGFCVAVTLIHCYFGYFAHGGPAGVGSASGRAIRMSLIVIVAMNFVLSVSIWGLSPVMVFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8L0</accession>
    <name>A0A231H8L0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45178">
        <property type="protein sequence ID" value="OXR45178"/>
        <property type="gene ID" value="B7C42_03136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="413"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="829" mass="88849" checksum="2ADDABA54490C3DE" modified="2017-10-25" version="1">MSTPVTTHGWLTRLLLAPGTALHDLAHALVSPLAIPAMTAVAGVLMVVRVLAGVRRRRLGAGARLITVMTPPQVDSKAATAVWLHLTGQLRPAWRRTLFGQPHLGFEYTITPEDGAAIRFWIPGSIPPGLVERAIASAWPGAHTDTQDCTEPPLPRPAGTRRVLAGGRLRLGRREALPIRTDHAGDLVRDLITAADDLGPGQGACVQILARPVTGRRVARATRSDRTRGGLVVGLARELLDILTPGSSRSSRDNKPPSDQQTAMEFASAARAAATKARGPHWETLIRYAASVPVDEQAGGVAEARRVARGRADALATVFGACADHNYYRRRRCWRLARALGERRLGRGDVLSVPELATLAHLPAEEGLPGLQRAGARALAPAPDIPASGEHTKPLGLADTASRRPVAVRIADARHHLHILGPTGVGKSTLLARTILADAEAERGLIVIDPKGDLVTDVLSRLPRRFADRVVLFDADSPAPPPCINPLDISQNGRAGLDLAVDNLVTIFRRVFAQWWGPRTDDVMRASLLTLCAQPGTATLEDLPRLLTEPAFRARVTRTTSDPVLRGFWEGYEQLSDAARAQVIGPLLNKLRAFLLRPFVRAAIAAGPSTVEFADVLDHGGICLARLPKGSLGEETSRLVGSLLVARTWQAATARARQPANDRADAALVLDEAHNFLNLSTTVEDMLAEARGLHLSLLLAHQNLAQLPRDLRDGISANARNKIIFAVSPDDARELARHTTPWLSEHDLTHLDAFHAAARLLVHGQQARPFTLTTEPLPPPTPGRARQIAAADRAGRSTRPGHHATGDPAGSATTGDDATSFPGVGDPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Z7</accession>
    <name>A0A231H8Z7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45167">
        <property type="protein sequence ID" value="OXR45167"/>
        <property type="gene ID" value="B7C42_03125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="33128" checksum="F6181C5AB5DE4B49" modified="2017-10-25" version="1">MSNSVLAVTQYPVPPLDLSAPSGLSWVFTVLCVVFGLVAVGYGAWLARRGEVMGLALLVGGLLTCTFEPLADYIGLLWFADDNVAVTVNLVGRHIPLYVVVGYMFFFGLLSYIDYRAIVLGAGRKYFLGSFAIAFVFDWTLQATGANFDLYRYYGADPFRIFGAPLWWFAIDGSATVLIAFVMFILRHRIVGWGRLLPVVCVLPLYAGWNAAVGMPIFAAKNSNFDPAVNGNGSNVLVLIGGLLTFAAVAFFGWIILGEIQRAQRGAGIPVMRRFSLRTLLFAPLAYEPVDARGARSSAVANQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H955</accession>
    <name>A0A231H955_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="3">1.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acr1_3</name>
        <name evidence="3" type="ORF">B7C42_02485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45360">
        <property type="protein sequence ID" value="OXR45360"/>
        <property type="gene ID" value="B7C42_02485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="35437" checksum="AE74A38F60325428" modified="2017-10-25" version="1">MSDNHAAEQGYLSRRRARRDLTGKHVVITGASSGIGRAAATAVAAKGAVVLLLARRDEELNAVVEEITAAGGKAYAYQCDVTDSDSVDRAVKSILDTHGHVDMLVNNAGRSIRRAVHRSTDRLHDFERTMAVNYFGAVRMTLALLPQMRERKSGHIVNISSAGVQVATPRFAAYLASKAALDKFTEVTAAEMLSDNITFTTIHMPLVRTPMIAPSGKQGPSESPEWAAATIVRALSERPRRIDVPVGTLAEYGTLFAPGIKDRVMHRYYRALPDSPAAKGELPVEDEPESEVPALQAKPQRRSSTAGRVTRSTLRRAARLVPGTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9L6</accession>
    <name>A0A231H9L6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL</fullName>
            <ecNumber evidence="2">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaL</name>
        <name evidence="2" type="ORF">B7C42_01936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45644">
        <property type="protein sequence ID" value="OXR45644"/>
        <property type="gene ID" value="B7C42_01936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="7"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="22636" checksum="0CC6C47BD09767F0" modified="2017-10-25" version="1">MSSEAMTTLDSTVPRLQEVFFAAEPALTKLDEITGDGDFGVNLREGLSEVAGRLAAPDSPAPWDTLRAVFLDEVGGTSGPLFGLLFQSLDTRAARSDSYIDALQAGISDGLAAIQRVGEAEVGDRTMVDALAPAVEALHAGDVGAMVSAAVDGALSTAALRARRGRASYLGERAVGHPDPGAVGVALLLCVLAEPVSGTEASDRERARLLDAVSGSTSGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAD4</accession>
    <name>A0A231HAD4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase FadD13</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45801">
        <property type="protein sequence ID" value="OXR45801"/>
        <property type="gene ID" value="B7C42_02093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="412"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="504" mass="52883" checksum="430350C0EEC38093" modified="2017-10-25" version="1">MGSDNNGVRIPASVAAILDPMLATRPGATAIEAVSGAWTYAELDEAAARAAGALWRLGVRPGDRVAACLPNDLPIVAAFHGAQRIGAVWAGIGEAAAASEQQLLCDLVEPSVVLAGPRFAPRVSQAVDPDRWTGLLRAADPPPRVETDPGAPAAIAFTSGTSGVPKAVVHSQRGMLLPGAVTVATRGWGPDLRRGDSFALTILNMMILSTLTTAQAGGTAVIMNRRDADGVAEWIAAHRVTVWNGAPAQLYDLARRTAELSSLREVWSGGGDTSDAVRDAFAETHGLVPRVTYGLTEAPTVVSIDPPGSAWRPGASGRVTPQFDVAAYDDDGRRLPAGEPGELRLAPAPAGPWAGRWTPMLGYWAEGRVRMGEPLPLPTGDIGAVDEEGWLRVIDRKKLVIIRGGANVYPLEVERVITGYPEVAAAAVCGIPDERLGQRVAAVVESTGPAIDFDALAAWCRRELASYKVPERWVQVPALPVNAMGKIRRTELAALVAAGPGEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAF4</accession>
    <name>A0A231HAF4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="6">1.1.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">garR_2</name>
        <name evidence="6" type="ORF">B7C42_02120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.60" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783435.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45828">
        <property type="protein sequence ID" value="OXR45828"/>
        <property type="gene ID" value="B7C42_02120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="164"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="27262" checksum="4EF57F4D169C4627" modified="2017-10-25" version="1">MRVGFIGLGSQGGPMARRIIAAGHPTTLWARRAATLEAFADTGAATAETPATLGAGSDLVCVCVVGDDDVREVLTGEHGVLAGMSAGGVVAVHSTVHPDTCRDLAKTAAVHGVSLIDAPVSGGGPAAEAGRLLVMAGGDAEVVQRCRPVFDSYADPVVHLGDVGSGQVTKLLNNLLFTANLATAMSTFTLGAGLGVDPARLGEVIAHGTANSFALGRIVDAGVSLDRLAQYAGALLRKDVSLVASLADAAGAEPGVVLTAADATLALMNHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAN4</accession>
    <name>A0A231HAN4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042699.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45911">
        <property type="protein sequence ID" value="OXR45911"/>
        <property type="gene ID" value="B7C42_02203"/>
    </dbReference>
    <dbReference type="GeneID" id="66720087"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_58" evidence="2">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="80" mass="8827" checksum="24FDCF8FD66E7C36" modified="2017-10-25" version="1">MSDRPAQGKSMLGKGTRVTGKSRDRLQTQLKKQYEAGASIRSLARETGRSYGFIHNVLVESHVQLRSRGGANRRKAVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAP8</accession>
    <name>A0A231HAP8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TetR_C_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45892">
        <property type="protein sequence ID" value="OXR45892"/>
        <property type="gene ID" value="B7C42_02184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_1" evidence="1">
        <location>
            <begin position="84"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="241" mass="25926" checksum="A6760AB263F2A181" modified="2017-10-25" version="1">MADSGEAVVAAGRRRGRPPRLNRRRILAAARDLEPENLTMQAVADALGVHRKSLNYHVSDRQGLLELVAFDAFDTRFGRVDLPERADWRELLRLFGHAVVDALVQVGALIAYVRFDGKAGLSALRLVERTMAALVRAGLDTSEAGRTLKLVAAMAYSAAREALDAGGGPIDPQAAAVRRTLGNEPGFPLLRAVATARETDGRVGEQFEFDLALIIEGLERRLEIRHGAGAPAAPGRAPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAU8</accession>
    <name>A0A231HAU8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator YvhJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yvhJ_2</name>
        <name evidence="5" type="ORF">B7C42_02293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR46000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46000">
        <property type="protein sequence ID" value="OXR46000"/>
        <property type="gene ID" value="B7C42_02293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="251"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="520"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="665" mass="69623" checksum="74B6F4B458CCB48B" modified="2017-10-25" version="1">MNDETEPIPVVDPRGGSGRSRHARPDDESPADRSGRHGPRTVRAGTPPWSRGIATPADQRDSERTRRATPPPAQRPARREQPAAEPSARRRPAPAQSPAPERGDTEPRRRATRTAPAAATTAAAAAETVAVAAEGAAPPPNRRARRARTAPPPRPNRGGRAVRVGGRLLAAVTAVVVVSGTGLAYYTERSVDQGFTRSNAISEADAAALDGDLNILLIGLDTRKDQNGNDLPKNILDQLHAGDGSEGGYNANSLILVHIPKDLKKVTAFSIPRDDYVSVSGIPGYDHAKIKEAYGLKKASVEQKLENQGVKDKVELERQGREAGRESIVQTVKQLTGVPINRFAEISLVGFYDLANILGGVDVCLNHAVDDEYYSGAVFPAGRQHLDAANALSFVRQRHGLDNGDLDRTHRQQAFLTSVAKQLKDSGTLTNIGKLQDLISAAQNDIVLSQGWNLLDFAQTLGRAGSIPIEFQTLPVKAYDTVDGQDVNIVDPAAIKKTVRTAFGVAEPQSSAPTTTPTSTVDVVNAGGAGGMAAKVSTALVDKGFRKGNVGNATYSDGSSSVVYFGSGADTDATQAADMLGGLPTAASKSLDPGTVKIVIGSDFSMPDSLTSTSASTVTTTDPTTGLTTTTSGGTSASTTATTDDRPDSGKPVTTSIGSDIPCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB42</accession>
    <name>A0A231HB42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46065">
        <property type="protein sequence ID" value="OXR46065"/>
        <property type="gene ID" value="B7C42_01028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="45" mass="4894" checksum="68BD0859116C0C81" modified="2017-10-25" version="1">MSDKSPRSTMSKKSGKSLKEKRAEKKAKGVTPSGVETTVDGKKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBD5</accession>
    <name>A0A231HBD5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rskA</name>
        <name evidence="3" type="ORF">B7C42_01155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46190">
        <property type="protein sequence ID" value="OXR46190"/>
        <property type="gene ID" value="B7C42_01155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="245" mass="25022" checksum="32DB5E8C73235325" modified="2017-10-25" version="1">MPDTSEHELLDLAYPYALDAVGDSERDEIEQRVAAAGPETSRAFTVVVRAVRETMGALSVLDAKEPAPELEARILAAIDRARPADPSAAVPLTRPSRRPRLRWLAAAAAVVVAAGVGGGIVAQQHAGQTANPPMAEQIMRQPDAHTASAPLSTGGVLMVHASIGMGAATVAFDSVPPAPQGHVYQLWVVPPTGAPRSAGVMDSMPSSSAPMVATYSGGDALAVTVEPAGGSPAPTTTPIGTMPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBP9</accession>
    <name>A0A231HBP9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA (Guanosine(18)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trmH</name>
        <name evidence="3" type="ORF">B7C42_01092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043377.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46127">
        <property type="protein sequence ID" value="OXR46127"/>
        <property type="gene ID" value="B7C42_01092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009020">
        <property type="term" value="F:tRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052665">
        <property type="term" value="F:tRNA (uracil-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="25661" checksum="1F7DBC688EEEA088" modified="2017-10-25" version="1">MTGVNHPLQPLPDPSDGEVPGPTEWGEHPHGVGPWRDEFGTEPPGDPRLDPELLAHGDRRNVVDAYRYWSREAIVADIDTRRHPFHIAIENFGHDANIGTVVRTANAFAAAAVHIVGRRRWNRRGAMVTDRYQHIVHHSDIAELLEFAEREHLTVVAVDNVPGSVPLETAALPRDCLLLFGQEGPGVTEAAKRAAAMTVSIAQFGSTRSINAGVAAGIAMHAWITQHADLERSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBT9</accession>
    <name>A0A231HBT9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46341">
        <property type="protein sequence ID" value="OXR46341"/>
        <property type="gene ID" value="B7C42_01307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="161"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="30463" checksum="F66F387B03AEEAE1" modified="2017-10-25" version="1">MPVQPVVLAGAVMDLAVPAGGGMPGVSMAGFRGRAGETVALQMIPYPALTVFVDFGDALVVDGVSGERTGGPLVVGLPRGALRGSGRAVDLLQIRLSPVVAHTVLGAGAELNGMVVGLGELWGGDAARIQERLRAARSWDTRFAIAHAALARRLATGPEVDPEVEFVWRRLTHSHGSARIEPLAAEVGWSRQRLWSRFRAQIGITPKQCARLVRFDHVAHRLAAGHRPARVAAETGFVDQSHLHRDIVDFAGMPASAVAAAPWLSVDHIAWPRRLPATRAPYPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC26</accession>
    <name>A0A231HC26_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46493">
        <property type="protein sequence ID" value="OXR46493"/>
        <property type="gene ID" value="B7C42_01463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="27738" checksum="7B24E7C02CFFD541" modified="2017-10-25" version="1">MRPLSWRELADLAFAVLQHRIRLIAGLAGAGSAVALGIVAGITALVSFATDGSSAGTAWAAILSTVCCAWVLRLWTVGVTVPIGLAVVGDHPITARIAAQRLFPVSGRLLLNQVISTSIGFGILLLGTPLIVTLIPAVIWLARVRGTRWPIAPVLFTESIPYRAAVRRAKLLTTGRVMPLAGLWLYLRAVLLVLAAPVAGLLGFLSDISGTHRWAVVILLSGAVLLISAFAAAVDAATAVVVHIDRRCGREGFDIRIPTGQATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCB6</accession>
    <name>A0A231HCB6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46530">
        <property type="protein sequence ID" value="OXR46530"/>
        <property type="gene ID" value="B7C42_01500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="28040" checksum="BD1C72A8C578FD23" modified="2017-10-25" version="1">MVPADRFAAAWPDPAAERDRFAIRVEIAIVLVVTFGTSGAGAALSLLESALAPGGIGGQQVALNPSRAAQSTIDLLFQLLSVARLIGWGALGLYLLWRSGIGPRLVGLARIRWRGDVIPGVVLAAVIGLPGLGLYLAAHALGVSVTIVPSSLHDHWWRLPVLVLSAVANAVAEEIIVVGYLISRLRTLGWSENRSLAASALLRGSYHLYQGLGGGLGNLVMGVIFGRYWQRTGRLWPLILAHATIDSVAYIGYTALHGHVSWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCR0</accession>
    <name>A0A231HCR0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85C</fullName>
            <ecNumber evidence="2">2.3.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbpC_2</name>
        <name evidence="2" type="ORF">B7C42_01547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775184.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46576">
        <property type="protein sequence ID" value="OXR46576"/>
        <property type="gene ID" value="B7C42_01547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013207">
        <property type="entry name" value="LGFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08310">
        <property type="entry name" value="LGFP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011270935" evidence="1">
        <location>
            <begin position="24"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="602" mass="64474" checksum="17BAA1D169419BD3" modified="2017-10-25" version="1">MLAAAVILPIASGITIAPLPASAEPAAVPAPAGATVEKVVWLTERRVALWVNSPSMGSPVQVQLLLARDWNSRPDARFPLLFMLDGLRAQDDESGWTKDAGAVDFYADKNVTVVLPIGGQSSFYSDWVQQDNGKNYKWETFLTKELPPLLENQWRATDAHGVEGLSMGGTAAMFLAGRNPGWVKYAASYSGFLTTTSVGMPQAIMFAMRDAGGFDANAMWGPPTNAEWSEHDPYQLAPKLKGISMYVSAGSGTTGAYDKPSDIPGISTNYAGMGLEMLSRLTSQNFVDKLNKLSIPVQANYRPSGTHSWPYWDFEMRQSWPQAAAALGVEADKPACAVNGAVAAAVQIDKWLGDCVTGEYQVTNGSAQDFKGGRMFWSQATGAHAVAGAIGGTYQATGGPGGPLGLPTYAEQPLPDGQGRFQTFQGGSVYWSPQTGAQVIRGAILAEWERQGFERGPAGYPTGPEARTPNKDGVVQGFQGGPMYFSDKTGAHRVQGLILGKYAQLGFENSWLGFPAAEEQPTKDLGRYSKFESGTIYWSPLSGAWAVRNGPIMDAWGQQGFENGKLGYPISDEFPVPGGVQQNFQTGFVVVRDGKPPEVHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCV5</accession>
    <name>A0A231HCV5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46632">
        <property type="protein sequence ID" value="OXR46632"/>
        <property type="gene ID" value="B7C42_01606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018330">
        <property type="entry name" value="RecT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03837">
        <property type="entry name" value="RecT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="415" mass="45913" checksum="D12192DDC375E968" modified="2017-10-25" version="1">MTTTEIALRGATRSALAITPDQNDWTPQQIAALRQLGIEDAPEGDLLVFRHVCMATGLDPFRKQIYMIGRKTKVKYWDDRQKKQVEDWVMKYTIQTGIDGFRKNGRAAAKREGEKISVDGPYWQGADGGGWHDVWLSDKPPAAAKFVIFRDGEPHTGIAMYREFVQTAPGSTGPNTMWAKMPANQLAKCAEAQAWRRAYPDDFAGMQLEDAAQIIDPDGAPADPVRAQSQRVTAGEILAGPASNPGEKPDTAQAEKPATRRKPRTKQVEQVTAEQLTEAKALFEQLGVPQDQMRAKVSEWLGIDFELDDVRRLTKVQGDELIADLTQRVAKLMTPATTEQIEALTAALVREKVTDENEQLTWVRNSVRNPDLQSLAQLTGTQAEDMTNFLIEAQAADERDRAGAQQALDTEAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCV8</accession>
    <name>A0A231HCV8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_01576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46605">
        <property type="protein sequence ID" value="OXR46605"/>
        <property type="gene ID" value="B7C42_01576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="99"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="25351" checksum="B50F686080A2C289" modified="2017-10-25" version="1">MKYGTPGGYRPGPQSRPLTLTVSGAGRCTRRDLAPFACAVSRSIAPAASPLATGIARWGTGVRYRRRVASSETATEPVDRTGDTLRHKVVTALRQGSAFLVVGAIGFLVDAGTYNLLVFWGGDGVLNRAPLVAKIISILVATVVTYFGNKWWTFAHKQGGSPAREYLLYTVFNVVAIGLQLGCLAFSRYVLHLSSPLADNISGTLIGQIVAVVFRYWAYDTFVFAESRSGRSDAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCY3</accession>
    <name>A0A231HCY3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA translocase SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIIE</name>
        <name evidence="3" type="ORF">B7C42_01609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46635">
        <property type="protein sequence ID" value="OXR46635"/>
        <property type="gene ID" value="B7C42_01609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ftsk_gamma" evidence="2">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="331" mass="36321" checksum="B460805580BCBEDB" modified="2017-10-25" version="1">MTTEFVVGTADLRRALEAIRPHVGKVTGTPEYARVRFIVGRENAVLTATDRFTAALAIVSIWEPGPRDGERSEVAEILISDVAKILTIHNVAGRESSDQPDYRLRIVISDEHFVVTDVSGLIEGRSLRVPRLATEDALSSVPLLIDHAHSGQLALLEDITDLTVNGDHLARFKAAASAYNSTLTMETRRYEHRKHTRLSVLVRCGESFLGLMVPRPVLDEDRVAAKQHAEDWNERLPAIVRSAPEAEADLLGRAVKLVVTMRNSMPSMLQRRLIIGYARAQGLLEKMTEHGILGADPGEGKNRPILVRVDELDEALARITGEPVAAASGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCZ1</accession>
    <name>A0A231HCZ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase YcgJ</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycgJ_1</name>
        <name evidence="2" type="ORF">B7C42_01762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46784">
        <property type="protein sequence ID" value="OXR46784"/>
        <property type="gene ID" value="B7C42_01762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="65"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="24142" checksum="85B61D44ECE6C259" modified="2017-10-25" version="1">MLLVEQALASDHEHMFRIEQDPHGILITNPRGYSAFTNVFFGGRRRRHAAALAAASGVRPGGRALDIASGPGTLVFALADRVGAGGEVVGVDAAREMVDYATARAGGRANCRFDYGVAQSLELPDAAFDVVTCTFGMHHIPEADRGRALAEMWRVLRPGGRVLLADLAPAGVHGQLTKRLSRHMDPAAVDIRRYRKALQETGFQDLDYRTIKPSTGVLTGVKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD06</accession>
    <name>A0A231HD06_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fadA_3</name>
        <name evidence="7" type="ORF">B7C42_01772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46794">
        <property type="protein sequence ID" value="OXR46794"/>
        <property type="gene ID" value="B7C42_01772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="281"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="42185" checksum="3C84DF04C6B54C2D" modified="2017-10-25" version="1">MTTEAYIFEAIRTPRGRNKKGSLHSVKPIDLTTGLVQELRNRFPNLDEDRISDIILGVVSPIGDQGADIARTTVLTAGLPDTVGGVQINRFCASGLEAVNMAAQKVRSGFEDLVIAGGVESMSRVPMGSDGGALFADPATSYDLYIAPQGIGADLIATIEGFTREDVDKFAVRSQELAAQAWSGGYFAKSVVPVKDINGLTVLDQDEHMRPGTTVEDLAKLKPSFAGIGEMGGFDAVALQKFHYIEQIDHVHHGGNSSGIVDGAALVLVGTEEAGAASGLTPRARIVATATSGADATIMLTGPTPAAHKALAKAGLSVDDIDLFEINEAFASVALKFQKDLKIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRNARYALVTLCIGGGMGVATIIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD17</accession>
    <name>A0A231HD17_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ArsA_ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041819.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46873">
        <property type="protein sequence ID" value="OXR46873"/>
        <property type="gene ID" value="B7C42_01852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="42500" checksum="9764FEC5757A07C1" modified="2017-10-25" version="1">MSHPSPLIPPATPLLDVEAVIADPTARVVVCCGSGGVGKTTTAAAIALRAAEQGRKVVVLTIDPARRLAQSLGVSDLGNAPQRVQLPETAEGELYAMMLNMRRTFDDMVLEHTSPDKAEQIFANPFYQTVASSFGGTQEYMAMEKLGQLVAKREWDLVVVDTPPSRNALDFLDAPKRLGNFLNGRMIRVIMAPGRGVGRFVTGAMSLAVRGVSTVVGGQMLKDASLFLQSLESMFGGFQDRAERTYAMLSRPGTHFVVVAAAEPDALREASFFVDRLSTDGMPLAGLVLNRTHPVLCTLSSAQATAAADRLSPGPGSASDGTAEEAVAAADAATDPATLTADILRIHAHRAVTAKREQHLLHRFTGAHPRVPIVTVTALPFEVSDLDALRAVGEQLAGSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD21</accession>
    <name>A0A231HD21_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46820">
        <property type="protein sequence ID" value="OXR46820"/>
        <property type="gene ID" value="B7C42_01798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8206" checksum="36A429E5156B2211" modified="2017-10-25" version="1">MVGYLRAATGIGRVRRPNSLPDQRRSRPGTALRGAATTAEPLRAIMIGANSPVHQRFPGSAGVGEPLPPEQPAYRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD22</accession>
    <name>A0A231HD22_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46702">
        <property type="protein sequence ID" value="OXR46702"/>
        <property type="gene ID" value="B7C42_01677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="39334" checksum="3F27A69E5DCE54FD" modified="2017-10-25" version="1">MSLLRKVEQGDRAASPAFIAAVARVLGVGIGDLTGQPYSPVRADAAAHATIPELRRSILAFDDEPPAIPLTFEDLSAALDRVREGMRRARYTDLTAELPDVIRGLHLLADAESPGSRSEEIHSALAYAYSKAMLFAYQYGYLDLAGLAADRCGWAASRSGDPIWPVAAEYNRALILLYSGAYAGGQKTIERAYAASEDIATSPNLLAVRGALHLRGSILAARAADAVTADSHLTEARQIADAIGSTRFRHYGTGFRPSNVDIHSVAIPVELSDGTTAISRAADIRLPASVAPSRAGHHFIDLSRAWLLHGDKQRALLTLQQARKVAPELTRNHSQVHETIRVLAHSRRGTDNLAQFARWANVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD24</accession>
    <name>A0A231HD24_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetracycline repressor protein class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tetR_5</name>
        <name evidence="6" type="ORF">B7C42_01809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46831">
        <property type="protein sequence ID" value="OXR46831"/>
        <property type="gene ID" value="B7C42_01809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="28827" checksum="4AA8D05D72B53A1E" modified="2017-10-25" version="1">MASRPDTTDSATTDSTPAESGETTQIRSVWTREHRQRREQPALSREQIVAEAIALLDAEGFESLSMRKLGSRLGAGATSLYTHVANKDELLELVVDEAFSELRLPAEPIADWRAAMLDLCHDIRRILLRHPWTSMVMTTAGLVYLGPNMLRLSESLLSISEGAGFDTATADRASNTLLAYVIGATSTEAAMLTSIARSGLDEQVWFDQFMAAAELAARPYPRISQRFAEHRGHDSTRIREDNFDEELGLILDGLHARRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD55</accession>
    <name>A0A231HD55_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein YdfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydfJ_2</name>
        <name evidence="8" type="ORF">B7C42_01703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46726">
        <property type="protein sequence ID" value="OXR46726"/>
        <property type="gene ID" value="B7C42_01703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="243"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="793" mass="84677" checksum="A383B104D9859582" modified="2017-10-25" version="1">MSVYLYRWGKFAFRRKWIVLPVWLLIFVIVGAVGVGLKKQSQDDFNMPDLPSQKATDILDREFPGQSAAFKFDAVTGTYVASATHGKLTDPDNHQALTALVEKINNLDIVDKSKINAQAPDPQRRGVLTDPVAATTAIGCTSGDRTDPNFVAKCGLAPLNVLGKNNNADTVAYFSVPFKIKSFSDITQADRDQAYKVADEARAAGLDVEISGTIATQQAPPGGQSEMIGYAVAFIVMMVAFGALIAAFVPILTGIVGVGMASSLIMAGTSIANIPNFTTVLAAMIGIALSIDYALFIVSRYKHELAVQDSPEEAAGVAIGTAGSAVVFAGMTVIIALCGLSIVGVSFLTWMGLGGALAALFAILVALTLLPAMMGAFGRFLFKPKLPLVARTDTEDDNAVTNGKRFARLIAKAPWVTLGASVIVLGLLAAPAVNLSLGLPGEDSQPKTTTVRKAYDLRTEGFGEGSNGTLLVVADLTKVKPEQRQEAVMALHDKLAGYQGMDFVTMPSTNKLTSEKTPDYVNSTGAQLTAVPDHGPNNSETQDLVKHARDAESDLQAKYGMEYGITGSTAIYADVSNALLGKIVPYMTIVAIAAFILLVLVFRSVLVPLTAALGFLLSMAATFGATVLIFQQDKLGLIGDQHPIVSFLPIMLIGLVFGLAMDYQVFLVTRMREEYVHGKSPKDAMVSGYHHGARVVTSAAIIMISVFGGFMLESDVTAKSMGFALAAGVLFDAFLVRMVLIPSLLVLLGKWAWWMPKWLDRILPDIDVEGTKLRELQQRDRDTAAEKEPVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDL5</accession>
    <name>A0A231HDL5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_00162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776964.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47043">
        <property type="protein sequence ID" value="OXR47043"/>
        <property type="gene ID" value="B7C42_00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="62" mass="6976" checksum="24CEF0D88F2F14C8" modified="2017-10-25" version="1">MHVSVDPDRCQGHARCWEICPEVFDLDDEGHGRATVSEIPAELRDRTREAADNCPERAIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDP7</accession>
    <name>A0A231HDP7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRP-like cAMP-activated global transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">crp</name>
        <name evidence="4" type="ORF">B7C42_01857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019044571.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46878">
        <property type="protein sequence ID" value="OXR46878"/>
        <property type="gene ID" value="B7C42_01857"/>
    </dbReference>
    <dbReference type="GeneID" id="66718485"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="24746" checksum="D0216E530B74157B" modified="2017-10-25" version="1">MDEALARAGIFQGVEPTAVAALAKQLQPVDFPRGHVIFNEGEPGDRLYIITSGKVKIGRRSPDGRENLLTIMGPSDMFGELSIFDPGPRTSTATTVTEVRAVTMDRDALKAWIDQRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKALLQLAQRFGTQEAGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWLRLEGKSVLISDSERLARRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDQ6</accession>
    <name>A0A231HDQ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46898">
        <property type="protein sequence ID" value="OXR46898"/>
        <property type="gene ID" value="B7C42_00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="18199" checksum="A2FCEF25C458C2E7" modified="2017-10-25" version="1">MLRWLDEQEQQTWSAYIRLRQRLDAAMAAGLARDGLSVPDYEILVALSDAREGSVRARDLAAQICWDKSRLSKHLARMDKRGLVVRSPAADDARGRLICLTDSGRRALEQAAPRHVDLVRRLFVDQLTDAEARALRSLADKVSARAERESDMPPAIGEVAHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE93</accession>
    <name>A0A231HE93_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47065">
        <property type="protein sequence ID" value="OXR47065"/>
        <property type="gene ID" value="B7C42_00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="26055" checksum="613546AC636DA624" modified="2017-10-25" version="1">MKQRHGARSHEARTHRQLQPADVHNRGSGATPLHILSAYSSPGHPSASPGHSSPGAITHRNTESAATAWSKSRVLLLNATYEPLTALPARRAIVLLVCDKADTVHHNPEGPVVHSAGASVALPSVIRLRNYVRVPYRARVPMTRAALMHRDRYRCAYCGGKAETIDHVIPRSRGGAHSWENCVASCAPCNHRKADKLLSELGWTLMHPLVSPTGPHWRLLSTTSDLDPVWLQYLGEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HET9</accession>
    <name>A0A231HET9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme chloroperoxidase</fullName>
            <ecNumber evidence="2">1.11.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cpo_1</name>
        <name evidence="2" type="ORF">B7C42_00522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.10" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47399">
        <property type="protein sequence ID" value="OXR47399"/>
        <property type="gene ID" value="B7C42_00522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016691">
        <property type="term" value="F:chloride peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="29910" checksum="7D3BE23B9C626ADC" modified="2017-10-25" version="1">MPFITTSDGVDIFYKDWGSGQPIVFSHGWPLSSDDWDAQLMFFLSHGFRVVAHDRRGHGRSAQVADGHDMDHYADDLAAVVTHLDLTNAVHIGHSTGGGEVVRYLTRHGQDRAAKAVLISAVPPIMVKTADNPGGLDKSVFDDIQEQVATRRSDFFRTFAEGPFYGYNRPGAQPSEGVIANWWRQGMAGGAKAHYDGVVAFSQTDFADELTKITIPTLVMHGEDDQVVPIENTGIRSAELLPNSTLKTYPGFPHGMPTTEAATINADLLAFIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEW7</accession>
    <name>A0A231HEW7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777076.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47217">
        <property type="protein sequence ID" value="OXR47217"/>
        <property type="gene ID" value="B7C42_00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31753" checksum="3A3D9A3D2DCC4C6E" modified="2017-10-25" version="1">MRIGIMLSEQTGPDALVRLTDELQQVAGEGFESAWLSHIFGLDALTALAVAGSKVPNIELGTAVVPTYPRHPGALAQQAATTALAVGRGRLTLGIGLSHQIVIENMFGYDFGRPARHMKEYLSILGPLLDGQPVSYQGETLSANLGLTAGETGRIPVLVAAMGTQMLKLAARRTDGTVLWMTGPATIADHIAPTITAAAAEAGRPAPRVVCSLPVLVTDDVDRGRERAATVFAAYGSLPSYRAMMDREGAEGPADLAIIGTEEQVAARIEKVFAAGATEFVAAPFVGGQAAERTRKLLTQLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFC6</accession>
    <name>A0A231HFC6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47518">
        <property type="protein sequence ID" value="OXR47518"/>
        <property type="gene ID" value="B7C42_00643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="162"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="39572" checksum="2CD915AAA878CB16" modified="2017-10-25" version="1">MHLRGVVLPGDEVRDLWVRDGTISFEPVRDAETLCDTGWIVPGLVDAHCHVGIRYGGGHEDREGAIAQAEVERDAGALLLRDAGSPIDTRFIDDHHELPKIIRAGRHIARPKRYIRELGIELDDERDLPEIAAEQARFGDGWVKIVGDWIDRSAGDLRPLWSDAILKEAIDAAHREGARVTAHVFGEDALPGLISAGIDCLEHGTGLTADTIEMMAEHGTALVPTLVNIDTFPDIADSATKFPVYAAHMRDLHRRVRDTVADAHAAGVPIYTGTDAGGSIKHGRIADEIDALAGAGLSRHEALAAASWRAREWLGRPGIEDGAPADFVVYRTDPRSSRDVLDAPAHVVLRGRVYPGRDPVTGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFD8</accession>
    <name>A0A231HFD8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispG_2</name>
        <name evidence="4" type="synonym">ispG</name>
        <name evidence="5" type="ORF">B7C42_00719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503535.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47594">
        <property type="protein sequence ID" value="OXR47594"/>
        <property type="gene ID" value="B7C42_00719"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="40428" checksum="93DF002AF7652786" modified="2017-10-25" version="1">MSTAITLGMPAAPAAVLAPRRKTRQLMVGTVGVGSDHPISVQSMTTTKTHDVNATLQQIAELTASGCDIVRVACPRQEDADALPMIAKKSQIPVIADIHFQPRYIFAAIDAGCAAVRVNPGNIKEFDGRVKEVAKAAGAAGIPIRIGVNAGSLDKRMLEKYGKATPEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPAEEVKVGGQILQSLNLRPRKLEIVSCPSCGRAQVDVYTLANEVTAGLEGLEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVVKTVPEHQIVETLIEEAMRIADEMGTDAETGEPVVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFE9</accession>
    <name>A0A231HFE9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efeB</name>
        <name evidence="7" type="ORF">B7C42_00694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47569">
        <property type="protein sequence ID" value="OXR47569"/>
        <property type="gene ID" value="B7C42_00694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014491406" description="Deferrochelatase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="411" mass="44282" checksum="03A65D64F454A36D" modified="2017-10-25" version="1">MNVSRRRFLSGAAAGAAGTALTAGILAEGARKDADAATVGTPKAEASYPFHGAHQAGILTPGPSAKQNAACFAAFDVTTTHRAELVEAMKALTARARFLTAGGAPTDLGLGQPPSDSAVLGPEVIADGLTVTTGVGASLFDGRFGLAAAKPAKLTPMRTFPNDTPDPAWMHGDLLIQLCAHHPDTVHHALRDITRQTRGALQLRWKIDGYNSPPRPSGTGRNLLGFKDGTANPTGADAESLIWTDGGGEPEWTRGGTYQVVRLIRMLVEFWDRVSINEQENMFGRRRDSGAPLDGNQEFDTPDYAADPEGSVIPLDSHIRLANPRTPETARQQLVRRSYNYDLGVERNGNMASGHIFTCFQQDVARQFEAIQTRLINEPLTDYVQPFGGGYFFALPGVRDEKDWYARALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFI6</accession>
    <name>A0A231HFI6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DhaL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47467">
        <property type="protein sequence ID" value="OXR47467"/>
        <property type="gene ID" value="B7C42_00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="624" mass="63787" checksum="32D83D6224CBA834" modified="2017-10-25" version="1">MRGVRERLDAAALRQWGALCVERLLAHREEINALNVFPVADSDTGTNLLITMRAALAATQAQGDADPSDAADPLGAMARAATAAACGNSGIILSQVLRGLAESADHDDLTAATLRIALRRAAVLVRESLSEPVEGTMLTVLEAAADRAEDCAEQTVAAVAVAAADGAVKALGETPSQLVVLRAAGVVDAGARGLLVLLDALVEVCTGSAPARPVYRVTASDAARTATGRVRHGADEDSPDVHANDTAVHADSSSELPEKAPLEVIAGDGPVTTRAVPPGNSDYAHIVSAPTRSADAALPVISPRQASGTEAVRRAGKESGRRHRASAPQYEVMYRIVESDPARIDRLRDALAALGDSVVVVGDGEGSWSAHVHCADAGAAVEAGLAAGVLGNIRIEGLFGTSVAAQGQSDRGILAIATGAGAVRLFEDSGAVVLTGAVTADRLLAAIRAMPQREVLVLPNGALPAPELVAIGMAARDGWREVMMLPSGSMVQGLAALALHDSGSLAVDDALTMSQSAASTRWGAVRVAAERALTIVGTCEEGDGLGLVGHDVVVIDPDLRRAARTLLDRMLGLGGELVTLLLGAQAPAGLADELTAHITTEFPGVEVVTYDGGQAVDLVQIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFV2</accession>
    <name>A0A231HFV2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47719">
        <property type="protein sequence ID" value="OXR47719"/>
        <property type="gene ID" value="B7C42_00844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="40526" checksum="93BFEDB52C76A0FC" modified="2017-10-25" version="1">MEIPHPDVRRTSGHRPLSASRHRPTPAPVTVNTGAPPLPQPRGELSAGICALLGGTACHVDFDTANADPYGEDLQLALHLCYELHYRGFDSVDPRWEWDPKLLRMRAHLEDRFLAAMRRDVPGGDDLDGELDDLLVEPVEGAGVGHFLNEQGQWWQVCEYFAHRSIYHHKEADPYAWVIPRLRGQAKAALVAVEYDEFGAGRGEDVHAQLFADLLAGAGLDNTYLHYLDAVPAPMLALVNMMSLFGLHRQYRGELVGHFASVEISSPPASRRMVETLRRLDAHPACVRFYAEHVEADAVHEQVMRRDVIGDLSAREPELIAPMVFGIQATTLLENAIDRHMLDSWSAGHSSLRDPEAIPRDRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGJ2</accession>
    <name>A0A231HGJ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator KdgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdgR_1</name>
        <name evidence="5" type="ORF">B7C42_00940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47815">
        <property type="protein sequence ID" value="OXR47815"/>
        <property type="gene ID" value="B7C42_00940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="71"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="28364" checksum="F55041B7BAE30622" modified="2017-10-25" version="1">MATVQLEQTPNAMIDRVASLLEAFVGQRPMTLADIARRSHLPRSSAHRILQRLVELGWVERHGFEYALGIRMFELGSQVVRQRSVNDVAMAVMTALHRRTGLTAHLSLLSGAEILHLNRVGAWPAPGRQWAVGARQPVELTAAGHALLAAMEPEQWPDLRFAGAPTCYSVRTRRQLERELEKVRDRSGVAVDSQGCALGVTVVAAALDIDVDRGRVAVSLCGPTRSIKTSAVVSEVRLAANEIRRVALAAPRTGLQPVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT91</accession>
    <name>A0A231GT91_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000070">
        <property type="protein sequence ID" value="OXR39765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39765">
        <property type="protein sequence ID" value="OXR39765"/>
        <property type="gene ID" value="B7C42_08166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="502" mass="54922" checksum="F5A1B3252643C225" modified="2017-10-25" version="1">MDPRELVIAENVRKDFDVAENPKQADSIREFGVGAPVLAEREPDGAVYVIDGQVRVLIAQAVGVSRVPVWITDAPTDVDAKQRRIDRTMAQINLNERRIPLTQADYAAGVALMLDLGASPTRVAKGLQQTKRADVRKLAAVGRSAAGRELADNGQYSLDQLAVIAEYDNLGDTDAVEKLTSASRYNFGYVAKAIAADREETRRRLHASLPYAAYGFGILTDEPGADDGYLPASDLVRADGEPVTDDDIYADPARWVVWVDVEENGELVDTATGALVDPDTVDWDTQHGPDAEPGDGLRRADGLAWRDRWIPAYYLPADQLDTTGLRLPVPAAADPQEALAATEGAAAAREESRLARRRVRELNKRGVAAAERREEFLTTYFKRNKPPTQAAHFVAEYLARNLAPGASQLVTKLLGISWSTEELMKVIGSASTNRAWVLALGMVLANREVTLDKSLWRTRSETTTRYLHLLADIAGPEDDFALVDVEQAAAGDIDYHDIPIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT93</accession>
    <name>A0A231GT93_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000058">
        <property type="protein sequence ID" value="OXR39843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39843">
        <property type="protein sequence ID" value="OXR39843"/>
        <property type="gene ID" value="B7C42_08084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="9280" checksum="7A09AB36D2714A2E" modified="2017-10-25" version="1">MTITGFLRWELGETPPAYVIERIPDGEAFAGALISPGERPGQMIALVFSPTSRTIGVEFVHLSKAHQNAIRKLKLGYEKGAVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTC0</accession>
    <name>A0A231GTC0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multifunctional conjugation protein TraI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">traI_2</name>
        <name evidence="3" type="ORF">B7C42_08066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000055">
        <property type="protein sequence ID" value="OXR39869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39869">
        <property type="protein sequence ID" value="OXR39869"/>
        <property type="gene ID" value="B7C42_08066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="2">
        <location>
            <begin position="11"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1368" mass="149458" checksum="5341781280303FD7" modified="2017-10-25" version="1">MTATLHKILAGTSYLYYQRQVAAADATDLGTSSLADYYSTRGEAPGTWHGTGLTALAISAGDQVAEDQMRCLFGLGRHPNATAIEYQVVTDAMAKGAKPKDAVYAAKQASRLGKAFPARHGDNTFRTRCAQAYREHNLAHGLDANAAIDEEIRARIRTDVATTMFVENYDRPPLDDRELSGFVARISRPQSAAVAGFDITFSPVKSVSALWAIAPKSIADAIQAAHNAAVDDAIAWLENNATYTRLGTGGVRQVDVEGLVAARFTHRESRAGDPDLHTHMLIANRVPTLDGKWRTLDATHFYRNLVVVSEIYNTRLEHHLETSLGIQFTERPAPTPNKRPIREIIGIPPELIRHWSRRDAAITHRLDSLAVSFQQQLGREPTPKELFALAERATLETRPAKHLSRSYAQQRHDWHTKAATLLGGPNAVDATVSSLLNRASGTRPTVDEAWISRTADEVIAVVSGQRSVWQHHHIRAETERQTRGHIQPTQWPNVVEAVVREALSPTRSLARGDPDITAEPVLQHSPEVLRRRDGTSVYTVPGSQTYTSARRLGTEQRLLDLSIQPSARTLPHDLVISAIDAYNTDPAHVRAQLNTGQTALITHFATSPAGIAVANAPAGTGKTTAMRVLVNAWHASGGTVLGLAPTAAAAAVLAENTGIRVETVDRLLHTLDRIQPRTPEQATASAEFPASVPEWMVQIDDRTLVIVDEHVKLGDDKRLRLFEFLTTRDATIRCLGDDKQLPSIEPGGTDTDTTHNAETPALTEVVRFASPAEARASLMLRDGDPAALGFYLDHQRIHSGTPAAVADKAYTAWFADHHHGRNTLMLATTHDIVTELNTRARTDRLTRTTDNPGPEVVLADGLAASAGDIICTRRNNPLLPVGDNDWVRNGYRWTITTVHPDGSLTATHHTNNGNSGATTLLPADYVAQHVRLGYALTLDSAQGITTDTCHTVLTGRESRNQLYVALTRGIHTNHAYIPTAPDYGEASPWAEPAILPRTSTEVLQHILARDATHTNAHNHLRDTLNPHKRLGHAIDTYLDATGIAIEHTLGPDTLHHIDTAADNLLPGLTDAPAYTVLRHHLATLALTGRDPVQALRTAAAERELDTAHDPAAVLDWRLDTTGAHSTQPGPLPWMPRHSHHITDPQLTEHLDARARIITTLTEQITTDTRTWTHTTAPPWAQPLLQNPLLIAELAVWRAAHHIPDTDLRPTGPRRYPTTERHHQHRLDTHITDALGDLHTATHTWSALAKRIDTRITTDPWWPTLAQHLDTAANAGHDIETLLTTAAAQRPLPDDMPAAALWHRLELPKRAPTDNAEADSGGAYIPSAGSAIESAVDTALPDTADLEYETVSGSEHDVHERSVITDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTZ4</accession>
    <name>A0A231GTZ4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40093">
        <property type="protein sequence ID" value="OXR40093"/>
        <property type="gene ID" value="B7C42_07848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="152"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="33851" checksum="48D47FE586971B08" modified="2017-10-25" version="1">MKAAWGRIALESFAVVATLVGAAGVALHFNRTESRWLILAASGAPYLMCAALLGVALFAAAKRWAGVAVAIAVVGVAIWTQAPLYVGRSPGDHGTPVTVMQSNLLFDGADPQALIEQVRERKVGILTVEELTPAAVHALEGVGLDRLLPHRYLSPGRTATGTGIWSAYPLSDTVECDGFVLNQLSATATVPGVGPVSVYAFHPVPPISGTHLWADELSRLRAILGRSPADRPVIVGGDFNATFDHAQFRAMLSGRFHDAAEQEGAGHLVTYPTDKRWPPLVGIDHILVADGHADTVDTIRLPGADHKALIAQLRLTRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV24</accession>
    <name>A0A231GV24_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6286 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40479">
        <property type="protein sequence ID" value="OXR40479"/>
        <property type="gene ID" value="B7C42_07417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="3">
        <location>
            <begin position="68"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20322" checksum="B556D67F0D13096D" modified="2017-10-25" version="1">MNRRPRRITPAVLVAVALLVIAVLVAVSLIQNLGNAKELVSYHSIAVHLHDTTWRSYWVLGVGIALAVLGAVLLLAALLPGRRVVEALDAGEGMDAGITRRSLDGALHDAAGSVAGLEAARVRRGRKNIRVSGRAAHPDHADLEQTVNAAVADRLARIAPKSAPPVSTRLRAAQQPERVDKRVHVRKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV32</accession>
    <name>A0A231GV32_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA:oxalate CoA-transferase</fullName>
            <ecNumber evidence="1">2.8.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfdE_4</name>
        <name evidence="1" type="ORF">B7C42_07496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.19" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40438">
        <property type="protein sequence ID" value="OXR40438"/>
        <property type="gene ID" value="B7C42_07496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="34471" checksum="771AA512498FBF2C" modified="2017-10-25" version="1">MLRAADGWIGLNLARPSDVELVPAWLEATGSDWESDIRQRSASVLAERARMLGLPASALPRNADEQLVARGQDREVRPFVLTGHAGPVARVVRDCLVIDLSALWAGPLCAHLLTTLGARVIKVESLLRPDGARNGPERFYDLLHSDQEAVALDFGTTKGRAQLAALIDAADIVIESSRPRALRHLGIRAEEVLARAGDKCWISITAYGRTGPWSNAVGFGDDVAVAAGLLAFDLETGIPAPCGDAIADPITGVNAALVAVACRMAGGRWLADLAMREQVAAVLDGRPEPYPDLVVAAPQTRHPRSRAPDVGADTARILREFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV47</accession>
    <name>A0A231GV47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063012258.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40494">
        <property type="protein sequence ID" value="OXR40494"/>
        <property type="gene ID" value="B7C42_07432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8431" checksum="930779E9D26BAB37" modified="2017-10-25" version="1">MTCQDRPPAPTVIDAGVERERIAALEKLRLRLESELDRTAAGTGYAAMAGQLRDTVNAIADARNRIYEVLLGDDEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVY4</accession>
    <name>A0A231GVY4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40732">
        <property type="protein sequence ID" value="OXR40732"/>
        <property type="gene ID" value="B7C42_07156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="13682" checksum="F435680B7F55FD2A" modified="2017-10-25" version="1">MADSNDVTLWKFLAEESKAGRLNLDPSVASDCLKACEDQLQVYRECRDMTRQMSHVTGLGDFPAADELAKMLGAKAVGGEGNFHEAFSEHIEVLTLIRDTIKSSVDRIGEQDRQNQREVAQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVY8</accession>
    <name>A0A231GVY8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40789">
        <property type="protein sequence ID" value="OXR40789"/>
        <property type="gene ID" value="B7C42_07072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="29006" checksum="1682E883C9780E64" modified="2017-10-25" version="1">MTIDDNPIAAFVPRLVDVDGVSKTVYTAGSGPAVVVMPEMPGISPDVLRLARWIRDAGFTVYLPSLFGVDGAYPTADDGAEVVRRACVSAEFRAFAGGGTSPVTRWLRGLARLAHDECGGPGVGALGLCFTGNFALTMTLEPAVVAPVVNHPSLPLDDPAGLELSEEDAAAIRDRIRRDGLTVLAYRFDNDRWCTGRRFAAYRALLGDAFDGRVLAGDAANPTPPPFFRDVVQTPHSIVTAHFVDQEGHPTRAARDEILAFLGARLHAPATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW15</accession>
    <name>A0A231GW15_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40768">
        <property type="protein sequence ID" value="OXR40768"/>
        <property type="gene ID" value="B7C42_07192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="34182" checksum="06D801702CDF34A0" modified="2017-10-25" version="1">MTLWEQINQPVTYAVPFFVLAMVLEIAALRGHAEDRAGYDVTDARTSLTMGFVSLFISGAAKFAALVGYAVLYVHAPWQVDPRNPLSWLAVMLAVDLLWYAYHRLAHRVRVVWAAHQVHHNSRYFNYATALRQKWNPWFELLAWVPLPLLGVPPWMIFTAWSFNLIYQFWVHTETIGKLPRWFEFVFNTPSHHRVHHASDREYLDRNYGGILILWDRMFGTFRAETFRPTYGLTKNIDSSNVLTLQYYEFGALWRDLRSTRRIREWAGYLFGPPGWDPGVARTGDIGDPLRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW99</accession>
    <name>A0A231GW99_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glyceraldehyde 3-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gpr_5</name>
        <name evidence="3" type="ORF">B7C42_07034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783816.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40899">
        <property type="protein sequence ID" value="OXR40899"/>
        <property type="gene ID" value="B7C42_07034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="35"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="37679" checksum="0BB42C2B69C5807E" modified="2017-10-25" version="1">MTVYTPDSPYSAADNRYETIPYRRSGRSGLDLPSISFGLWQKFGTDYPFATQREIILHAFDLGITHFDNADRYGPPHRAAQLTFGAVLSKDLAPYRDELILSTKAGNPIGASPYLRGGSRKSLVGSLEHSLRDLGTDYVDIFYHHSPDLETPLEETVGALVDVVRQGKALYVGISNYRPDRAHEIAELLRGEGVPLLIHQTRYSIYDRGPEQSGLLDTASADGFGVIVYSPLAQGLLTDKYLETIPEGARARNSAFLSPEVIDDTYRQRTAALNKIAESRGQSLAQLALQWVLRRPEVTSALIGASSTGQLDHNLAALSFPALTEEELALIEEHGVHGTGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD3</accession>
    <name>A0A231GWD3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative enoyl-CoA hydratase</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadB_5</name>
        <name evidence="6" type="ORF">B7C42_07064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783771.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40929">
        <property type="protein sequence ID" value="OXR40929"/>
        <property type="gene ID" value="B7C42_07064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="28037" checksum="7C74922F4412CBB0" modified="2017-10-25" version="1">MPEKTTRATGCLRSETSEGIATITIDRPPANAFDPGLTAELLEVLPPLANDPGVRCIVLRGTGRFFVAGADIAVMRDLTEQTQRAMRPWVDVQRLLETAPKPVLAALNGHALGGGAELALACDMRVMAESATIGFPEISLGLFPGAGGSQRLPRLLGAHRAKLLMMEGTRLAATDAVRIGLVDRVAPDAEFDETIAMTARALADKPTRTIGLLKHVVREGLSLPLEEALDIEFAAVLELIRTADAAEGLQAFLDKRAPEFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWG1</accession>
    <name>A0A231GWG1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40963">
        <property type="protein sequence ID" value="OXR40963"/>
        <property type="gene ID" value="B7C42_06929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="765" mass="77858" checksum="57FED7BCCA320163" modified="2017-10-25" version="1">MNMFGRGDHRSDHDSERDDTDYGDSYYGEGYAEGGYRTGTHRAPDPGDGGEYGESAYATGYSEPEYPAGRTGGRHGRAEPDQEMTPPGYGSPGRPAPPPYPGGRPDPYETGTHARVPARPGTPPRGEVPARPPRRAPGGPRPDLPPVPGDMDDTGPIPRIPPGPLPPRHAGGSGAIPRVPGGPAGTGAMPRIPGGPGGTGAIPRVPGGPVGSGATRRVPGGPAGTGATPRIPGGPAGTGATPRIPGGAHDVGAVPRNPGPSAGTGPTWRNPPGPEGTGAVPRLPGAAPGPVGPVTGAVRRIPPGANPAGPPTGSVPRLPAGPGRPVPGPGAGPGGRPAPGSPPAAAPPPPRRRPEPMGAHSPTATGRHPVVPAHQRPDSGDADYGHPQRGRHRPADVDTGYREPAQPRAAVPAPPDPYADHGYDPAESGPATGGFAAADPYRQPAGAHAGDAYAETPGYAGEPAGTSGYANGSAYAGAEAYAEDDGYDAEPLDHDADEYDADEYDAGYTDSDYEYDADDYDDEDGETEDSAPRTGPFDYEEVSEILAEISDQHLDLGSVLLPVPDGGQLQVEMTPDGTPQAVHLATPHGRLTVAAYAAPKSPGQWRTVAADLAESLRADGAQVSVQTGPWGRELHAVTEGADLRFIGVDGYRWMVRLVAAGPSGAADEGGPLVEAARAILAETVVRRGDEPMPVREPLPVVLPQELADQLIAAHQQQVEAQQQALAAQAAAAEAAATGTFPVVTAEQQGPRRGAGGSAMQQLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWY1</accession>
    <name>A0A231GWY1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41124">
        <property type="protein sequence ID" value="OXR41124"/>
        <property type="gene ID" value="B7C42_06894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="27002" checksum="882851F90E25EBCB" modified="2017-10-25" version="1">MIKTRSLVCSECGHDFEQVVRQGGRKAMTCSPECKKVRANRLFNERYVPTSDRRKRGTNKGCEAPDCDGRAKAKGLCSMHYKRLHDSGEIGPGGPVKDRCWAEGCESGTWARGLCRFHYQRVWTTGDPGPLRRKKRPNGQGRSLVRGYVRMTTPDGRRMDEHRFVMEQHLGRPLRRDESVHHKNGVRDDNRLENLELWVKPQLAGQRVEDLVDFVVSSYPAIVAAALEKAQLDNLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX06</accession>
    <name>A0A231GX06_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor KstR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kstR_4</name>
        <name evidence="5" type="ORF">B7C42_06732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783068.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41136">
        <property type="protein sequence ID" value="OXR41136"/>
        <property type="gene ID" value="B7C42_06732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="21719" checksum="3E06EEB8FF3DDB9D" modified="2017-10-25" version="1">MVRTNPERRQALLDASIEVLAREGARGLTFRAVDQEAGVPAGTASNYFPNRDALLVQVGNRYYERLIPSEEAMAKSRGPQTRESMTELMTEVVERVFHFRTGYLAILELRLEATRRPELQALLTERVRADLDFNIANFRESQLPGDEDAVVLLYLALNWLILERLTLPGIFDERRAAELVHTIVERAIPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX92</accession>
    <name>A0A231GX92_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoyl-CoA reductase subunit B</fullName>
            <ecNumber evidence="2">1.3.7.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bcrB</name>
        <name evidence="2" type="ORF">B7C42_06642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.7.8" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41244">
        <property type="protein sequence ID" value="OXR41244"/>
        <property type="gene ID" value="B7C42_06642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018522">
        <property type="term" value="F:benzoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="446" mass="50076" checksum="4DC26A70225C9F84" modified="2017-10-25" version="1">MTTQQSSTEKANRLSSTRAGGRMVADYWDNIFTAKERGKHVVWYNGAAMNPLFQAAGLEWCHGEAFAARLAAQHLEGPAQAAGAEYGYIGELCSYARTHLGCAVLTHQTVNGQSTGVVGMVDQQELAAKLPAPDFFVNGYAGCSTGQQWDAMTYRVFDRKLPLFNVSMPMLWGNKPDAGYMRGEEWTEVSRYVEGQLRELIGFLEHQTGRSFDWDALSESMFYIKRASELRLEGMALCAQAPTPATYWDWVASIAPINFLPGNQALVDYFAGVKAEIEQRLADGVSAVADERYRVYFDGIMNWNKLGFLTRKFAEYDVAVVAGRYTHESFWQEPQLIDPDNPLLGMAQHYLLCPLNHGLKNLQELLLRRLDEYAIDGIAFHSTRTCRAMTNPQAMLARTAEQERGVKSFFFEGDVADASFYNDELFDSRLEAMLEAIDVQRMKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXH3</accession>
    <name>A0A231GXH3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41317">
        <property type="protein sequence ID" value="OXR41317"/>
        <property type="gene ID" value="B7C42_06715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="37309" checksum="CC58D56E4B2DC0B2" modified="2017-10-25" version="1">MVNTSGTTFRDPLVGPEVTDLPDGFFDRLMFNAHPVDATTPSVIMGFGIYPPKGTVDGFVVVSGEHEQRNLRYSGPLGATNRDGSGPFRFEVVEPNQTWRLRLGPNEIDTEFDLTWRARTPAWFGEIAVTNASAERTSFDHLFQSGRYAGTLTIDGRPHSVDGWYGQRDRSRGVRTMAGGQGLHIWYQAQFPDFSIGFLLVETRSHERLLLEGAVMHESGRLDPITDVRHALVFTPDLDLVEGEVRVETAAGEHYVVQADGRAGGGFMAGAGYGGHHGNSSGADRIESDSYRLDGSVTPCSLDSALTDRLCSFTLGDVRGSGIFEFALTRSSKYHYRPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY05</accession>
    <name>A0A231GY05_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782552.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41504">
        <property type="protein sequence ID" value="OXR41504"/>
        <property type="gene ID" value="B7C42_06396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12510" checksum="471BD2AA9A9BB827" modified="2017-10-25" version="1">MTFLALGYLRRDVSRRHQHWDESQIRWLAGRLGYNLCKTVALSNRTCDPIQQLIDAVVRLDAEAVVVPSLDHFADRVIPADLLAITDVVTVTPEHTYARWASGELPELNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY30</accession>
    <name>A0A231GY30_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_20</name>
        <name evidence="3" type="ORF">B7C42_06419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41527">
        <property type="protein sequence ID" value="OXR41527"/>
        <property type="gene ID" value="B7C42_06419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="423"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="512" mass="55414" checksum="4A67A7866EB3D670" modified="2017-10-25" version="1">MSLDPCTHTIDGVLHRSAAKVPGRTALTFDGRSYTYRELDAAVTRAAAHLLDLGLAAGDRVAAYGTNSDAYVIGFLACARAGLVHVPVNYALKGGELSYLVAQSGARAVLADPALIGTLDHVRGDLTAVEYVVPLRDADGSLRAVADAAGEVSDFSSRAAATDLAQLLYTSGTTSKPKGAMMTHEALVFEYVSSVIALDLRPDDNPLVAMPLYHSAGMHVFMLPYLSVGATVHLMATPDIPEILRRIEQDRIGSLFLAPTVWVPLSHHPDLDRRDLSSLRKAQYGASIMPVTVLNRLRERYPDLGFYNCFGQSEIGPLATVLRPEEHAERPSSCGRPVFFVETRVVDTEGNDVGPGEPGEVLYRSPQLCRGYWDNPDATAEAFRDGWFHSGDLVTRDADGYITVVDRIKDVINTGGILVASREVEDALYTHPAVAEVAVIGIPDEKWIEAVTAVVVLHEGRETTADALIAHVKDLIAPFKVPKSIRFAAALPRNQSGKLLKRELREPMTTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYB8</accession>
    <name>A0A231GYB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783606.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41590">
        <property type="protein sequence ID" value="OXR41590"/>
        <property type="gene ID" value="B7C42_06231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="22"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="32055" checksum="C34F0969F9FBBE56" modified="2017-10-25" version="1">MQEHGTRTSVSTGRAVRLESFGGPEVLDLQEVPAPQAGAGQIRVRVTAAGLNPMDWFMTSDADTAARFGLSAPAGFGTDYAGVVDQVGDGVTGFAVGDRVFGGALSRAVADFVVVDVAGSIAKGGQAHHIPDGVDDRAAAVLTIAGCTAAAALAVVDPGPGDTVLIGGAAGGVGVFAVQLARLAGARVIGTGSPASEDFLRHLGAEPVAYGEGLADRVRGLAPESVTAAIDLHGLETAQVARELGVADTRITTIAGQIDGITPANGADADPGTLEEIARLVAANEIDVPIAATFPVDRIRAAVELQAGRHVHGKVVIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYE4</accession>
    <name>A0A231GYE4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">drrA_11</name>
        <name evidence="6" type="ORF">B7C42_06285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036501587.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41644">
        <property type="protein sequence ID" value="OXR41644"/>
        <property type="gene ID" value="B7C42_06285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="34751" checksum="CDA66F7AA1BEFAEB" modified="2017-10-25" version="1">MSLAVEVTDLVKTYGKARVLDGIDLEIPSGTVMGLLGPNGAGKTTTVRIVTTLLKPTSGNVRVAGVDVVHHPARVRTRIGLSGQYAAVDENLSGFENLRMVARLYGMDHKKSAERATELLSALGLEHAAGRRAGTYSGGMARRLDLAGALVARPTVVVLDEPTTGLDPRGRLDMWKVIGDLVDDGTTVLLTTQYLEEADQLADRITVIDKGKVIARGSADELKTSIGGDRLTVTLAEGQDPGPAKSVLSEVGLGEPIHEPGADHVSIVVGDGTRTMVEALRRLDDAGVCVVDAEVTRPSLDDVFLSLTGTPAEPIEESETEDVAEEIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYP3</accession>
    <name>A0A231GYP3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulatory protein GabR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gabR</name>
        <name evidence="3" type="ORF">B7C42_06068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41726">
        <property type="protein sequence ID" value="OXR41726"/>
        <property type="gene ID" value="B7C42_06068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="470" mass="50043" checksum="190886A1D5B72D36" modified="2017-10-25" version="1">MDELPLAVDRSDRRPLSVQIADELRNAATDGRLRGGDRMPSSRALAARLGVSRTVVTAAYDQLHAEGWISGRHGSGTYLTAAPAPASNHAGAQADSDSAGELLDLAPGAPCAEAMDSAAWRRAWRAAGDRGPAVRKDRAGDPGYRAMVAEHLLRHRGLRVDQPARIIATAGTSSAVAEFARAVLRPGDAVAIEDPGYLRAVGAFRSAGVEVVPVPMDRDGILVESIPAHVRAVYCTPAHQFPLGVRMPAGRRIQLVDLARRTGAVIIEDDYDGELRYDSAPLPLLAGLAPDLVVHLGTTSKILSPTLGVGWLVAAPWIVAAVLEHRESTGAWPAPAGQLVLAELARHGDLARHLRRLRREVPPRRTLTVTELRRHGLDIRGDDAGSHLVVPLPDAAAEGRAIALARRRGVLLDGLARHHAGPRQAFGIALGYTAVPRDQLPRALRIAAECLAAAAHGTHTDVRATFQGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYP4</accession>
    <name>A0A231GYP4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">B7C42_06086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41744">
        <property type="protein sequence ID" value="OXR41744"/>
        <property type="gene ID" value="B7C42_06086"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="534" mass="56208" checksum="9189AC866B77A373" modified="2017-10-25" version="1">MSERSERPEDTGARRAIRRALVSVYDKTGLIELATGLNDAGVELVSTGSTAARIADAGIPVTKVEDLTGFPETLDGRVKTLHPRVHAGILADTRKQEHLDQLVELGVEAFQLVVVNLYPFTQTVAGGATPDECVEQIDIGGPSMVRAAAKNHPSVAVVVDTGDYDDVLAAVRGGGFTLAERTTLAAKAFQHTASYDVAVASWMTNVLTAEDATDSAAGGQFPSWLGGVWTRDAVLRYGENPHQAAALYRNDSGPAGLAQAKQVHGKEMSYNNYTDADAAWRAAWDHAEPAVAIVKHANPCGIAVGADIAEAHRKAHACDPVSAFGGVIAANREVTVEMAEQVAEIFTEVIVAPGYADGAVEVLQRKKNVRILIADEPRRGGVELRPISGGALLQQTDIVDADGDDPANWTLATGEPADAETLADLEFAWRACRAVKSNAILLAHDGASVGVGMGQVNRVDAVHLAVLRAGDRAKGSVAASDAYFPFPDGPQQLIAAGVKAIVQPGGSVRDQLTIDACREAGVTMYLTGARHFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYQ3</accession>
    <name>A0A231GYQ3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41737">
        <property type="protein sequence ID" value="OXR41737"/>
        <property type="gene ID" value="B7C42_06079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="19501" checksum="F3E0E98DA7926CBA" modified="2017-10-25" version="1">MIEIRTVGADDWQLWRQARLAALAGAPEAFRTRLADWQGDGDREDRWRARLSIPGAHDLLALRHGEPVGIASGVPEPDHGAARVISVWVDRSARGSGVGDLLLRDLERWAAEGGYTTLRLDVFTDNEHAIALYRRNGFEFLPERDEPATPDELTDRRSQTRVERVMVKAVAPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZA7</accession>
    <name>A0A231GZA7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranial dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">geoB_5</name>
        <name evidence="5" type="ORF">B7C42_05889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.86" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41905">
        <property type="protein sequence ID" value="OXR41905"/>
        <property type="gene ID" value="B7C42_05889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="25"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="495" mass="52238" checksum="83970425942A71DD" modified="2017-10-25" version="1">MTTTDTAVAAPTVADREQVFIGGRWVDSAGAEWIDLIDPWSEQRAARIRSATADDVARAVETARRSFDSGVWSAKTMAERADVIDEIGTRLERRIEELTTIGVLEVGVPVSVSGPTQQMSAGLFHAVAAEARRFEQREDRVRADGGVSRILREPTGVVAAIIPWNGPIGTIAFKVAPALAAGCSVILKAAPDAPLSPSVFADVIAELVEEGLLPEGVVSVLVADREVSEKLVTDPGVDHITFTGSTAAGRRIAALAGDRIARVSLELGGKSAAIVLDDADLNHVLQSLPMGGCMQSGQACIALTRVLVSRRRHDEVVGALAAAYGALPMGNPWEPQNFLGPLAGARHRDRVQGYIDSAVADGARVVVGGGAPEGVTQGYFVAPTLLDGVRNDMRIAQEEVFGPVISVITYEDEDDAVAIANDSIYGLSGAIYTEDLDRGYALAQRIRTGTVSVNGSVIDFTLPFGGYKQSGIGREGGVEGLEEFFETKTVHMPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZP6</accession>
    <name>A0A231GZP6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate-import permease protein PhnE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phnE</name>
        <name evidence="6" type="ORF">B7C42_05669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42070">
        <property type="protein sequence ID" value="OXR42070"/>
        <property type="gene ID" value="B7C42_05669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="280" mass="29600" checksum="8C6F3BEFA51D18B2" modified="2017-10-25" version="1">MTTTITPPSADFAAAPERRIRRKRISSVASVAVIVIAFVASTIHLDVSAGQVLAAMPAFGRFIAENMWPPDFKGLSDLLLATLVTIEVAFLGTLLAAVVSLPLALLGARNLAPHRSVFVVVRFLIMVCRAVPDFVFALMFVAALGLGPLPGILGLAIHSIGMLGNSIGMLGKVYAERIEEVDPGPGEALAAVGASPLQIVKHAVLPQIMPSLVANTLYRFDINIRSSIVLGIVGAGGIGYELVTALQALDYRRAAAVMIIVLVLVAIVEAVSNRIRRSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZS5</accession>
    <name>A0A231GZS5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778948.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42021">
        <property type="protein sequence ID" value="OXR42021"/>
        <property type="gene ID" value="B7C42_06005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="120" mass="12749" checksum="ECCD8AFDA342ECAE" modified="2017-10-25" version="1">MDGGCLCGNIRFSATGDPDFPHLCSCEHCQRLSGAPVMAWVSFPEKGFAWTGPGGEPAWFETFPQICRGFCPKCGSSIASKGDEPGLVGVTITALDNHSGLIPVKQSFAHNAVPWLAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZT8</accession>
    <name>A0A231GZT8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator BlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blaI_2</name>
        <name evidence="2" type="ORF">B7C42_06015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42031">
        <property type="protein sequence ID" value="OXR42031"/>
        <property type="gene ID" value="B7C42_06015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="15277" checksum="307C3FB37EF0168A" modified="2017-10-25" version="1">MAHRFGDLEAVVMDRIWSAPDTITVRTVFEDLLRSREIAYTTVMTTMDNLHRKGWLEREREGKAYRYRARLSREQYSAQLMREALGGGRSDLVLAHFVEQISDDDTAALRKVLRRAKSRNPHTEQPGTEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B4</accession>
    <name>A0A231H0B4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_Apea domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42313">
        <property type="protein sequence ID" value="OXR42313"/>
        <property type="gene ID" value="B7C42_05512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041229">
        <property type="entry name" value="HEPN_Apea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18739">
        <property type="entry name" value="HEPN_Apea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_Apea" evidence="1">
        <location>
            <begin position="349"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="497" mass="55250" checksum="1BBD337EC67A2157" modified="2017-10-25" version="1">MPMEEPQAEDSTVDEPLDPDLWKLVLPAIRRAASVADAHLSKGGWYPRVRMPHVADLESGWPYLREPNWFPPDDAPVAYAELFTSENDGLSGLTYADIDEFAALYEYVIRDRGLRERLWPFKGASEERSDRMVEYEAAALPLSILDRARSIGKTTDDDYLSLYIQRERAWLLEALPVEYVIPLVLTELPLEAGEIVAIDPTVSLVRLERNDHLARAVSNSGTSNVPDMVVGAAKYAIVLSGHQWANLGPGQRLVKPPEAPSLTDVDMVCDALRILTGIDTGYAQVLCRPVGWADTWTYDLPVLLQIGTYRRYPEKFDRFGWMGRGEPVSREELNRLPMLVAALRGAPAKVHLAARRLSQAALRDSDDDRIIDACIGLEALLGEGRDELSHRLALRAATALASRRDSAFNPHMIYDLMKKIYNYRSIVVHGSSSVKSQTIDVNGLLVPAASLSVILLRELLKDLLSGVELWTAKSLDSRLLDALGPERSSADSADDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0C2</accession>
    <name>A0A231H0C2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ogt_3</name>
        <name evidence="7" type="ORF">B7C42_05471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42272">
        <property type="protein sequence ID" value="OXR42272"/>
        <property type="gene ID" value="B7C42_05471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="18798" checksum="F556E04012FDA0DD" modified="2017-10-25" version="1">MKTADYATVPTPIGPFTVIADADGAVLASGWTADAEGLRGLVHPQLRPAALRRYDALDELTDTVERYHQGELDAIDGVAVRQVSGPFLEHAWSVLRAVPAGAPITYTAFALRSGRPEAVRAAANACARNAAALFVPCHRILRTDGSLGGFRWGLGCKRWLLAHERAAEDKAQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0D1</accession>
    <name>A0A231H0D1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42201">
        <property type="protein sequence ID" value="OXR42201"/>
        <property type="gene ID" value="B7C42_05800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17735" checksum="AEA717480D929991" modified="2017-10-25" version="1">MTVIHNLPAHVLFVHFIVVLVPLTAILEIVCAVWPAARRGLLVWLTLVLAVIVMVLTPITIHAGQWLYNLRRNPDAILREHAERGETMLYFAIALLVVAVALTGLHLAERRGADLRALATVGVAVLAVVVGIASIVQTYRVGDAGSQSVWGDEIARLQKNRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0V5</accession>
    <name>A0A231H0V5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="5">FBPase class 1</shortName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">fbp</name>
        <name evidence="9" type="ORF">B7C42_05286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778673.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42510">
        <property type="protein sequence ID" value="OXR42510"/>
        <property type="gene ID" value="B7C42_05286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBPase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FBPase_C" evidence="8">
        <location>
            <begin position="200"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="39199" checksum="75D4BF91F7824E7E" modified="2017-10-25" version="1">MPDGMKTLTRYTIEQEHRHPGSSGEFSALLNVVSTAAKIIANQVTRGRIVGALGESDGADPPLSLHRRMDAIANDIMVEQSESSGPLSALLSEQMHGFHPVVGEVRRGKYMLAFDPLDGSSNIDVNLPVGTIFSVLRAPEDGRAPQAADFLQPGVRQVCAGFTLYGPATMLVLTTGSGVDGFTLDREIGAFVLTHPGMRIPEDTSGFAINAANERFWQRPVRRYVHECLDGVDGPRARDFNMRWVASLVADAFHILTRGGVYLYPYDTRDPGRPGRVSLLYGANPIAFVIEQAGGAATTGHERVLEVVPEHPHQQIPLVFGSRNEVRRIERYHREPDAGPPFDASLFGTRTLFRPARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0W1</accession>
    <name>A0A231H0W1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42515">
        <property type="protein sequence ID" value="OXR42515"/>
        <property type="gene ID" value="B7C42_05291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046288">
        <property type="entry name" value="DUF6325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19850">
        <property type="entry name" value="DUF6325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="15695" checksum="75B15E75479DF0C6" modified="2017-10-25" version="1">MNSAADIDEMGPIDYLVIEFPADRQPDGSALPMLRDLVDRGVIRVLDLAFVHKDADGSLTGIDIADVGLTGDLDVTLFAEAATGLLDEGDLREAGGALEPGHSAAVLLYENTWAAPLAVALRRNGAELVASGRIPVQAILSTLDSLEADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Y2</accession>
    <name>A0A231H0Y2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribulose bisphosphate carboxylase small subunit</fullName>
            <shortName evidence="3">RuBisCO small subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbxSC</name>
        <name evidence="3" type="synonym">cbbS</name>
        <name evidence="5" type="ORF">B7C42_05284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexadecamer of 8 large and 8 small subunits.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RuBisCO small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782033.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42508">
        <property type="protein sequence ID" value="OXR42508"/>
        <property type="gene ID" value="B7C42_05284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03527">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00859">
        <property type="entry name" value="RuBisCO_S_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024681">
        <property type="entry name" value="RuBisCO_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000894">
        <property type="entry name" value="RuBisCO_ssu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036385">
        <property type="entry name" value="RuBisCO_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31262">
        <property type="entry name" value="PTHR31262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00101">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00961">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55239">
        <property type="entry name" value="SSF55239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="2 3" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_small" evidence="4">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="16170" checksum="D33B9B5785ACBFD4" modified="2017-10-25" version="1">MHLRQGTFSHLPDLSDTEIGAQIRYALLNNWPVSIEYTDDPHPRNVYWEMWGLPLFDLDEPDGVLAEVNACRSTFPHHYIRVNAYDASYGRQTTALSFLVQRPADEPGFLVVRTETEDRRQHYGLRSYATDVPAGARYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H112</accession>
    <name>A0A231H112_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42538">
        <property type="protein sequence ID" value="OXR42538"/>
        <property type="gene ID" value="B7C42_05314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="372" mass="39965" checksum="72459CAA4A1A3EA7" modified="2017-10-25" version="1">MHTEICERLGIDVPIFAFTHCRDVAAAVSNAGGLGVLGAVGFTAEELEVELAWLDEHVHGVYGVDLVIPSKYEGKGIDGLSPAQLEAELAKLVPQGHRDFAEKILADHGVPKLPADEHHEQLLGWTATTAGPQVDVILKHPKAKLVANALGTPPDDIIKKVQDSGRLIGALCGSVKHALNHKRAGLDFVVCQGTEGGGHCGEISSLVLWPQVIDAVGDLPVLAAGGIGNGRQIAAAMSMGAAGAWTGSIWLTVEEANVPPAQMQTYIDATSHDTVRSRAWTGKPARMLRNDWTEAWERPDTPDPLGMPLQMMVALDGVKRGHRYPEAAKDVNFNPVGQVVGMMNKVERTSDVMQRLMEEYLEACERLNKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H168</accession>
    <name>A0A231H168_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_8</name>
        <name evidence="4" type="ORF">B7C42_05359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42582">
        <property type="protein sequence ID" value="OXR42582"/>
        <property type="gene ID" value="B7C42_05359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="38803" checksum="503B9C40CE86953B" modified="2017-10-25" version="1">MSSFPPLLGVELSGTGIHPASWRRADSRAEELFTPGYWLDAITAADRAGLDFVFLPDTFGVDAHGYGPLDAIALAARAAAATRSIGLIPQATVTHTEPFHVSKAIAALDYATYGRAGWEVAVSADAEQTTLFGRKQPQDDASLWREADEAIEVVTRLWDSWEDDAEIRDLATGRFIDRDRLHYIDFEGENFSVKGPSITPRPPQGQPPIAVRAESPASTRLAVHRADLIRVGAADLDEAAALRTRLRSAVAAAGRSPDEVRILLDVEVHLAATEDRAHAELDQLDAWGPAAPPATVRHLGTADGLRALLDRAQRECAADGLVLRPLAVPAFTAALDRPARSLRARIGLTRPANRYAVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H198</accession>
    <name>A0A231H198_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nickel-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nikA_1</name>
        <name evidence="3" type="ORF">B7C42_05364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42587">
        <property type="protein sequence ID" value="OXR42587"/>
        <property type="gene ID" value="B7C42_05364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371112" evidence="1">
        <location>
            <begin position="31"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="80"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="535" mass="56699" checksum="300DFA9BCBBFF9DE" modified="2017-10-25" version="1">MKRILSPALALTATLAIAACANTTGGGGDAGPPQPGGTLRYGLSQAPTCSDPAQAGTNQTLYVARQIVDSLTDQDPASGEIKPWLATSWQVSPDAKTFIFHLRPDVTFSDGTPLNATSVQKNFDAIVHTLTAAKAPLGASYLAGYAGTTAVDPLTAEVRFDAPNAQFLQASSTPQLGILADATTAKPAEQRCLGDNIGSGPFVYAGYRQDASATLVKRPGYRWGSAVFAHSGEAYLDRIEFTVVPEAGVRTGSLSSNQLDAVSDALPQDVPQLEAAGAKVQFDSNPGVPFGLQPNVSRAPLSDSAVRQALLHGIDRKQLVDTVLGPQFLPATGPLASKTPGYVDLSKSIAYDPDQARRILDQAGWVPGGDGIRVKDGRRLSFGVLFGAQFAANQATLELVQQQLRKIGVDIRLELTPVADYTARQNSGDFDATYFNTTRADGDILRTTFGRGQRNLNQRGPIPALDQALADQLSTTDPAARAGIIGQAQRSVIENGLWLPTIELSQAIGVSGAVHDLRFEASARLQFYDTWLSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1A9</accession>
    <name>A0A231H1A9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778213.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42643">
        <property type="protein sequence ID" value="OXR42643"/>
        <property type="gene ID" value="B7C42_05421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="160" mass="17477" checksum="AFB68EAF204CAEA0" modified="2017-10-25" version="1">MTQQTSDTQVRVELTVEAPIDTAFDVFTTGMDSWWPREHHIGAGPLAEVVVEPRVGGRLFGREADGTECPWGRVLVWDRPGHFAFSWDISLDWKYQPDPALTSRVDVTFTPVDATHTAVTLVHGDFGNHGEGWESMRDAVGSPGGWPGLADTYARAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1G4</accession>
    <name>A0A231H1G4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutamine amidotransferase YafJ</fullName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yafJ</name>
        <name evidence="2" type="ORF">B7C42_05435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42657">
        <property type="protein sequence ID" value="OXR42657"/>
        <property type="gene ID" value="B7C42_05435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="31115" checksum="6D68F1D52A5B50FC" modified="2017-10-25" version="1">MCRLFGLSAAPQRVHATFWLLEASDSLARQSRREPDGTGLGTFEADGEPLVRKQPIAAYEDQQFVREAMECESATFLAHVRYASTGATVAANTHPFEQHGRLFAHNGVVGGLPELERALGDYRELVAGQTDSERVFALITRCVDEHDGDVVAGIGAAVGWIADNLPVFALNFVLTTAQDLWALRYPDTHDLFVLERAAGGPGGGKHLDHAGTGPLRAHSPALADHPAVVIATERMDADPGWRELPVGRLLHVGPDLVTTSHTVVDHAPRHRLTLADLGEHAAASQRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1H7</accession>
    <name>A0A231H1H7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytochrome P450 126</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42667">
        <property type="protein sequence ID" value="OXR42667"/>
        <property type="gene ID" value="B7C42_05445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="44974" checksum="3F80D3B191D846C8" modified="2017-10-25" version="1">MDEDVDLTDLDRFTSGFPHPLFDRLRREAPVWFHPPTAHSPGGDGFWVLSRYGDIVAAATDTTVFSSESGGGRDGGGTTLEDMPLGVPVGALLNMMDDPRHAKIRRLLAPSTTPRALRRIEADLRRRAADIVDVAVAEGECDFLTDVAAELPLQAVAELAGVPQADRHELMNWANVTLDYDGREVGEVDDRLARAQARMFAYAADLLQRKRVAPGADLLSVITHALVDDEPLTDAEQHLFLSLIVAAGSETTRNSIALGTAALSESPQLWKQLQQDRTRLPGAIEEMLRWASSTPYNRRTATEDVWIGGHRIAAGDKVALWWASANRDDSVFTDPHRFDITRNPNPHLAFGRGVHFCLGASLARMEMRVLFDALLDRVETLTPRGPVEYVRSNKHTGIRHMPVTIGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1J4</accession>
    <name>A0A231H1J4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_13</name>
        <name evidence="2" type="ORF">B7C42_05060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776857.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42723">
        <property type="protein sequence ID" value="OXR42723"/>
        <property type="gene ID" value="B7C42_05060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="29126" checksum="132F623014CCBABB" modified="2017-10-25" version="1">MAPVTRASSGASAVRIVRKNFSDTVVSALRTFGRAVDIARESVTGTTTDIVRREFQWREAILQAWRLVTVTAIPAILIAIPFGVIVSVQVGNLIHTLGADSLLGATGGLGVIKQGAPLATGFLLGGAGAAAIAADLGARTIREEIDALNTMGISPIHRLVIPRLVAMILVAPLLNILIIFVGIVAGYAVAVGGQNVTPGSYWATFGSFTTVADVWVSLLKAVLFGFLVVIIACQRGLEAKGGPRGVADAVNAAVVLSVVSIAIVNLGVTQVVEMFLPTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1T6</accession>
    <name>A0A231H1T6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42787">
        <property type="protein sequence ID" value="OXR42787"/>
        <property type="gene ID" value="B7C42_05125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="120"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="388" mass="40671" checksum="1808F934AD5FB963" modified="2017-10-25" version="1">MLRNILRPIVGLLSIVAIAGVVALAVVMFRGGFADTVRVTVLSPRAGLVMYPDAKVKMRGVTVGKVAAVDERPDGLAAIQLAIDADQVRRIPSNVTVDIASTTVFGAKFIEFLPPAQKSATSIHAGQIFDSGHVTVEINTIFERLTAVLGQIEPEKLNETLGAIAGATNGRGEQVGQMLTDLDSFLAKIQPALPALSREITAGPNVAASYGDAAPDLLSTARNATTISRTVVDEQANLDALLVNAIGLADVGNQVLGDNGAPLASMLHLLVPTTDLAAEYAPALKCSIEGLDYMDNVKPVQVPGMGLTVNFLWGAEPYRYPRDLPKVAASGGPQCSVLPVPYNGKPKFVVVDDGAVPFPNTNRTLRVNPDLLQSVLFGAVDPTAGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1T9</accession>
    <name>A0A231H1T9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotinylated protein TB7.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036504493.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42806">
        <property type="protein sequence ID" value="OXR42806"/>
        <property type="gene ID" value="B7C42_05144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="71" mass="7437" checksum="97F7E307ABD5090F" modified="2017-10-25" version="1">MAEEVLAEMVSTVFQIVAHEGAAVREGDTLVLLESMKMEIPVVAEADGTVASINVKPGDVLQKGDLIAVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Z7</accession>
    <name>A0A231H1Z7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Voltage-gated potassium channel Kch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kch</name>
        <name evidence="3" type="ORF">B7C42_05206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780170.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42868">
        <property type="protein sequence ID" value="OXR42868"/>
        <property type="gene ID" value="B7C42_05206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="37992" checksum="C44BF76CB7CD42E3" modified="2017-10-25" version="1">MFGDSSRGLGRLTERPDYALVGILRIPEIRTSPWVSLTRRVAFAVLLLVAATLVVYFGRAGYHDNRGEELTLLDAAYYSTVSLSTTGYGDITPITEQARLINTIVITPLRVLFLIVLVGTTLQVLTERSRQAFKIQRWRQRVRNHTVVVGYGTKGRTAVDAMLGDGVQPAEIVVVDTDATVLEAAANAGLVTVHGSATQSDVLRLAGAQHAASLVIAANRDDTAVLVTLTARELNAKAKIVASIREAENTHLLRQSGADSVVVSSETAGRLLGIATTTPSVVDMIEDLLTPEAGFAIAERDVESDEVGGSPRHLRDIVLGVVREGTLIRVDEPEVDALETGDKLLYIRRVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H201</accession>
    <name>A0A231H201_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">narG_1</name>
        <name evidence="15" type="ORF">B7C42_05195</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42857">
        <property type="protein sequence ID" value="OXR42857"/>
        <property type="gene ID" value="B7C42_05195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1255"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR42857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1277" mass="140429" checksum="12317F6BD71FD44D" modified="2017-10-25" version="1">MCLDGGVVVISHEKGSAPSSTPNGVPAVSNGVAAVSNGVAESAADALLKVGRYFQRGEVSGDLRTVHKVGGREADEFYRDRWAHDKVVRSTHGVNCTGSCSWKIYVSDGVITWESQQTDYPSVGADKPEYEPRGCPRGASFSWYTYSPARVRYPYVRGVLLEMYREAKARLKDPVLAWESIVEDPEQAKTYKSARGKGGFVRAEWWEAAEIAAAAHVYTIKRYGPDRIAGFSPIPAMSMVSHAVGARFISLLGGSMLSFYDWYADLPVASPQVFGDQTDVPESADWFDAGYLIMWGSNVPVTRTPDAHYMTEARYRGQKVVVVSPDYADNTKFADEWVPARPGTDAALAMAMGHVVLREFFVDRSTARFDDYIKRYTDLPFLITLDERDGGWSGEGEYRGHTWLPGKFLTAADLAAAGLPGFDVDNAEHKTVLLDGDGNPVVPNGTLGDRFSESGAGRWNLDLGDVDPLMTLYGRTDDAAAVQFPRFDGETGTVTRSVPTTVVAGRRVTTVFDLLLAQYGVGRPDLAGDWPTGYDDPSAPYTPAWQESITGVPAAQAIRIAREFADNADRSGGRSMILMGAGTNHWFHSDQIYRAFFTLTLLTGCQGVNGGGWAHYVGQEKCRPVTGWSTLAFGLDWQRSPRQMQGTVFWYLTNDQWRYDPFTSETFASPLGSGAFAGRTAADNIALASRLGWMPTYPTFDRNPLDLVDAAEAAGQTPQDYVVGNLKSGDLEFACEDPDAPRNFPRVLTVWRANLLGSSGKGNEYFHRHLLGADSNLQADDSAGVPPQEVRRPEQAPTGKLDLLVSLDFRMTSTTLFSDIVLPAATWYEKHDLSSTDMHPFVHAFSPAISPPWEAKTDFEAFHRIARGFSWLAEKHLGIRKDLVAVPLQHDSADALAQARGRVLDWKTGECEPVPGRTMPKLVVVERDYPKLAEKMAALGPLIETLGVTTKGVTTVPDAEVEYLRGVNGTVVSGVAQGRPSLAKDVHAAEAVLALSGTTNGRLAVEGFHALERRTGTRLADLAAEHEGKRITFADTQARPVPVITSPEWSGSETGGRRYSPFTINTERLKPWHTLTGRQHFYLDHDWMIELGEQLPIFRPPLDMSVLFREPDVGAVGERGVTVRYLTPHSKWSIHSAYQDNLHMLTLSRGGQAIWMSDRDAAKIGVADNDWIEAVNRNGVVVARAIVSHRMPEGTVFMYHAQDRAVDVPRIEGTPDMRAGRGKRGGIHNALTRIMIKPTHLIGGYAQQSFALNYHGPTGNQRDEVTTIRRRSQEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H223</accession>
    <name>A0A231H223_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42895">
        <property type="protein sequence ID" value="OXR42895"/>
        <property type="gene ID" value="B7C42_04781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="90"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="26872" checksum="8FDDDF119B1A7D8D" modified="2017-10-25" version="1">MTLVRYGPHPSQHGILSVPDRPGLWPVAVVIHGGFWRTAYDADLTSGPAADLARHGFAAWNLEYRRVGDDPDRGSGGWPATCLDVAAAVDRLAAIGRSLETGGLDLSRVVAIGHSAGGQLAGWLAGRGSLPAGAPGASPRVPLTGFVSQAGVLDLQLALKEDLGSGAVRNFLGARADDPEAVSPACPTALLPMGVPSICVHGTADDDVPLSQSQRFVTAARRAGDDSRLLALPGIDHFALIDVTSSAWAACRAAVRELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H249</accession>
    <name>A0A231H249_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42921">
        <property type="protein sequence ID" value="OXR42921"/>
        <property type="gene ID" value="B7C42_04807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="165"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="345" mass="37529" checksum="8AB11ACEEC495DDF" modified="2017-10-25" version="1">MVHRRSGSPITLCRVAISKVERLMNLVIALLSTRQFLTAERIRDSVAGYEESASDEAFSRMFERDKNELRDLGIPLEVGPVGRFSGQEGYRINRDAYELPDIDLTSAEAAAVAVAVQLWESPELASAAESAVFKLRAAGVHVDADAASASVPAVPARTRGSEAALGKLLAAIDAGRAVRFEHRVTHNAPYTTRDVEPWGVVTRHGRWYLVGHDRDRDAVRTFRLSRIGADVEIYGPENAVHKPADVDLRQIVARVTGAAPVTGSATVWVAQERGQEIRRLGVVIAEETVAGRPGSVVEVPVRSRDWLARLITGLGPDALVLAPEDLRADVIARLRSVLERTEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2N1</accession>
    <name>A0A231H2N1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777922.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43096">
        <property type="protein sequence ID" value="OXR43096"/>
        <property type="gene ID" value="B7C42_04982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="239" mass="26110" checksum="EFC94B803AB383ED" modified="2017-10-25" version="1">MTAARRGRMPAVSDADIRRVARTLLVEQGPEAVTLRAIARELGITAPALYRYYASRDDLVGALRSDICADLAHELAEQVAELPEDGMVQLFAICKGFRQWALAHAHEFTLVFASPAGGSASAMRQFDEPFGRIFLEAAGRLLTTYDIVTPPTDVIPHALREDLVGFQTELLAVLAESGQKFPAEKLDLGVTYLMIQFWARLYGHVTLEVFGNYPMPVGNPDALFDATLADLARSIGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Q0</accession>
    <name>A0A231H2Q0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43116">
        <property type="protein sequence ID" value="OXR43116"/>
        <property type="gene ID" value="B7C42_05002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11451" checksum="47F31CD1D3F05575" modified="2017-10-25" version="1">MIEQRRDRRIRALHDKIRHLEQTATTDIAVHHTKQAAAVARMNEHGCSTDDIAELLKVSLKGVRQLLAAGRAKPEPGVQTAHRESESPLNAPQRSMESAEQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2V8</accession>
    <name>A0A231H2V8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crt_10</name>
        <name evidence="1" type="ORF">B7C42_04612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43190">
        <property type="protein sequence ID" value="OXR43190"/>
        <property type="gene ID" value="B7C42_04612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29571" checksum="E2B257DEBA4317E0" modified="2017-10-25" version="1">MSAQEQPKPPSGDWLGTPYLRFERDGVFAVCTVDRPEARNALTPAMYFGLRYVINRVDRDPAVAGLLLTGTGDTFVPGGDLGKSGTDDWLDFETALGMDVTPFDTLRRSAKPVVCAVNGLCQGGGLMIALCSDLAVVSDRASFRVPELLRGIADTYYAQVLARVVGVVRARDLLLTGRTLSAQEALDWGLVSRVVPHDELLGAATEALAQICRTAPAARREIKASLDGYLGHFARIAMESSLAGPEALEGFQAFKQRRSPHWVPAELRRDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Q5</accession>
    <name>A0A231H3Q5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43507">
        <property type="protein sequence ID" value="OXR43507"/>
        <property type="gene ID" value="B7C42_04374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="206" mass="22098" checksum="75B88D74274DA871" modified="2017-10-25" version="1">MTTRRGAGPITWRQRPAFRAPGRRPTARAFYANLVVMLVVSVALLSGCAGGSERAEPPASATSTPRQLEAAPAPDPGTPDGVAVAALREIFTWYPATEMQGASLARARKWLGPSLLRTLDAPPGEETPKPTLRWAEWGRSGVRVEAFTFASGEQAPGNGDSDHQQFKIGIEQTAVHSDGSRETLPPTTVIATVVRTPDGWRLDGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3S4</accession>
    <name>A0A231H3S4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782503.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43412">
        <property type="protein sequence ID" value="OXR43412"/>
        <property type="gene ID" value="B7C42_04279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7702" checksum="38337C0D528030BE" modified="2017-10-25" version="1">MDRGNTKHGAREDDQLRHELQGTLRGNRSSRAEEWRDPEPPADDDPQLTPPRTTTPEGAEHDRTGEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3X7</accession>
    <name>A0A231H3X7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator TtgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ttgR_3</name>
        <name evidence="5" type="ORF">B7C42_04436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43568">
        <property type="protein sequence ID" value="OXR43568"/>
        <property type="gene ID" value="B7C42_04436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="21496" checksum="FCC20E4E17973E1C" modified="2017-10-25" version="1">MTNSVDSTRAGGKRERLAAAAAEVFHRQGVEKTTIADIARAAEVPVGNVYYYFKTKDQLIRAAIGAHAQTLNGFLAELDREPRPVDRVRALIRSWVDQRDLAARYGCPSGTLATELDKRSDGMEQELAEVMGVLLAWVQRQFEEMGRADARELAVALIASYQGISLLTNTFRDPELMRTEGDRLERWIDSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H405</accession>
    <name>A0A231H405_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">def_2</name>
        <name evidence="2" type="synonym">def</name>
        <name evidence="3" type="ORF">B7C42_04439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43571">
        <property type="protein sequence ID" value="OXR43571"/>
        <property type="gene ID" value="B7C42_04439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20238" checksum="D2C7519BA115AEBB" modified="2017-10-25" version="1">MTIQPVRLFGDPVLRARADEVDAFDRDLEQLVTDLTDTMHASRGVGMAAPQIGVGLRVFVYDTGDAAGHVVNPVFEVLGADEQTGPEGCLSIPGLRYDVTRAHRVVARGVDMHGEPVKFEAEGLLSRCVQHETDHLDGVLYLQRLEPATRKQAMRAVRESEWFVAGKTVMSAAEVAGSRPESGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H443</accession>
    <name>A0A231H443_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_04458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43590">
        <property type="protein sequence ID" value="OXR43590"/>
        <property type="gene ID" value="B7C42_04458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="682" mass="72006" checksum="FA3C47ED6E41165E" modified="2017-10-25" version="1">MSSTSTAAAPTLLTGLWRRKLPHYPDTPARSWYLTLVVITSIVLYYQLFVAGAVGNQLIAYFHLSFAYFVWIFIIGAAFGAAASVAAGLLDRWGRANIVAYGVVICSLLTLFALPATTTKVAYLVVYCVVSVVEGAVLVATPALIRDFSPQLGRASAMGFWTLGPVIGALVTSEITARTLDSHPDWQFHYRLCGVISCAVAVVAVIGLRELSPRLRDQVMVSLRDRALVEARAKGLDVEALERGQWRQMMRVDVVGSALAISIFLAFFYTIVSFLPVYLATNFGFTPAQANALGNWYWIANAVALVVTGIVSDILKVRKPFMILGALISIAGLYVFLGYTDHPDTGYYSFAVVMTVIAVGGGIAYATWMASFTETVERHNPAATAVGLAVWGGVLRTVVTFTLFGLLMVVDAAGPLVNNGPRLQEIQAQYGPQLATIQTVGAQTMTQLGANPADPAAQMAALTKLTGAAPADIQATIALNARYPQELATLQAVDPATLGALAVNPTDARAAGAAVGQVAAKFGISPAEAAGRLAATQQVPRDQLAVASTVGPKLVTAQSQLQAVATVPADDLAYVAAHGPEVKQAAADSPVQWRQWWWICLIAQVLFLPFVFLMAGRWSPKRAAADAAEHDLRVRRELVALAEADAGVRTTAEPVAVAGSASGADESAEGEAAPPAEPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4F9</accession>
    <name>A0A231H4F9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43596">
        <property type="protein sequence ID" value="OXR43596"/>
        <property type="gene ID" value="B7C42_04464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="36328" checksum="D57BFD962DE02224" modified="2017-10-25" version="1">MLAKLRIDGFLLGLFAAMAIGLILPARGGAADVLEWVTKVAIAVLFLLYGTRLEPREALAGLRHWRLHTTVLTATYVLFPLLGLAMRLLVPSVLSDELYTGMLYLCLLPSTVQSSIAFTAIARGNVAAAVVSASVSNLLGVFLTPLLVMLLMQTTGDATVSPMAIVQIVVQLLLPFIAGQLLRPKLHRLLAHTTLTKVVDRGSVYLVVYAAFSAGMVEHVWQGLAVGRLLAVVGVAIVLLAVVLGVTAGAARLLGFDRADRIVVIFCGSKKSLATGLPMATVLFAGHPVGLIVLPLMIFHQIQLITCAALAGRWARAADKAEAARTAVTSPDAAVPDITPAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H506</accession>
    <name>A0A231H506_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43872">
        <property type="protein sequence ID" value="OXR43872"/>
        <property type="gene ID" value="B7C42_04111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="133"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="428" mass="45970" checksum="95D027F5781CF8C5" modified="2017-10-25" version="1">MQAALGKGSRRDPLTAIRESGRGTKIALALGTVAVVVVAGVLWWLFSSYNTTKITAYFDKSIGIYEGSEVRILGVPVGKVDSVTPQGDQVKVTMHVDRKYNIPADAKAAQITPSVVSDRYIQLTPVYKGGPKMPRNATIPRDRTATPVEVDRLYKSIQELSDALGPNGANKDGAVNELVRTGAANLSGNGDALANSLTQLSHAARYLSDARGDIFDTIKNLQVFVHTLAVNDQQVRQFNTQLADLAGFLSGERENLGQALNLLSIALGDVARFIDDNRDLVAENADALTKLTQTLADQRQDVANALPVLPVALSNLINIHNGESGTLDMRANFTDLQNPFGTVCKMLDLGQLRPGDPKFDAISRQMRPILDQCKVITDQIKSGVQTPSLVLPFGILSGENIQNTPAPGSVPGTPSDRQPPSQQEGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5T6</accession>
    <name>A0A231H5T6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase C</fullName>
            <ecNumber evidence="3">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">plcA_2</name>
        <name evidence="8" type="ORF">B7C42_03810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777593.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44249">
        <property type="protein sequence ID" value="OXR44249"/>
        <property type="gene ID" value="B7C42_03810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="509" mass="54382" checksum="F352A7359E7606CD" modified="2017-10-25" version="1">MGLFDGIKRRDFLAKAMAAGGVGALAAWANPIIERAHAADPAGMGGLGDIEHFVLLMQENRSFDHYFGTLSGVRGFDDASPAWKQYGYAPGVGPTADGFIVPFRLDTTRGATLDGECVNDPDHSWGGMHEAWNGGRNDRWMPMSVASVGAANGPAAMGYYTRADIPIHHELADAFTLCDHYHSSVLGPTDPNRLYWISATIDPDGLAGGPLVETPTLIPQNAYSWRTYPENLSEAGVDWKIYNNRDVGPISSVILDGMMGCFKQAADPNSELARRGKAPVYPQDFAADVAADRLPSVSWVIPPLLNCEHPALPPALGAVGIMQVLDILTSNPKVWEKTALIVSYDENGGFFDHVTPPTPPPGTPGEYLTVDLGRVPAAKGVAGPIGLGYRVPCFVISPYSRGGLVASQTFDHTSQLRLLERRFGVEVPNVTAWRRSVTGDMTSAFDFGSTPDSVPPRITDPKPKSDAALAQCGPNIALGTEDKGIPYPVPPNAMPSQEPGARRSPSGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H616</accession>
    <name>A0A231H616_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775754.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44453">
        <property type="protein sequence ID" value="OXR44453"/>
        <property type="gene ID" value="B7C42_03242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="251"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="476"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="857" mass="92974" checksum="58C1DDF44BBE6782" modified="2017-10-25" version="1">MSAQDLPHELRRALSAVARVPRLLVASDYDGTIAPIVSDPAKAYPHRESVSALRALAGLTTTTAAVISGRALRDLAALSRLPVEVQLIGSHGSEFDVGFVHAIDNDAKQLLTEVRHALAAIADDNPGVTVEAKPASIALHVRNATPEVGRRALQQARQGPASWVGIQVTEGKAVIELAVIQTDKGAALDIIRHQEGASAAVFFGDDVTDEKAFARLSGPDIGIKVGDGESLAEYRVPSTEEVAKALAFLLEERRTWLAGASAPRIERLTMLASPRSKALLTPDGTVSWFCHPEPDSAAVFAHLLGGPAAGHFTIAPERQSLPLSQRYVDGTMTVETRWSSLKIVDYLPHDVALERTDLTRVITGDARAVVTFAPRPEFGQVPVTLVREPAGLRVHGTNDPIVLRSPGVQWEISEEGIHHVARAVVDPSQGPIVLEMRCGTSDLAPAMVSEADRRNEAERYWRDWASDLNLPPLKPDLMKRSALTLRGLVHAPSGSILAAATTSLPEDIGGVRNWDYRYCWLRDASLTAHALVTLGSLSEAEDFLAWTHRVLETLAGPERLHPLYTLYGETLPPEAVLDQLPGYAGSRPVRVGNAANMQVQLDVFGPIVDLIAALAEAREGKGILDPAKALPDRDWELVQAMVSAVQRRWREPDHGIWEIRGNPRHHVYSKVMGWLTVDRALKLAERFDRGIDPVWVELRETIADEVKAKGWNEQVQSYTAAYDGTDLDAATLHIGLSGLIEPSDPRFAATVVATEAELRSGSTVYRYHHDDGLPGGEGGFHLCAAWLVEAYLLIGKREDAEALFAQLVDVAGPTGLLSEEYDPVAERSLGNHPQAYSHLGLLRCAQLLSQPVAAMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H632</accession>
    <name>A0A231H632_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tyrS</name>
        <name evidence="9" type="ORF">B7C42_03915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44354">
        <property type="protein sequence ID" value="OXR44354"/>
        <property type="gene ID" value="B7C42_03915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="248"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="444" mass="48142" checksum="7F88C949A48F0C71" modified="2017-10-25" version="1">MADPAQPIAPGAEEWEGVSADIIDELTWRGLIAQSTDLDALRADTAKGPITLYAGFDPTAASLHAGHLVPLLTLKRFQQAGHRPIVLAGGATGLIGDPRDVGERVMNSTDTVAEWADRIRGQLQRFVDFDESPTGAIIANNMDWTGNLSAVDFLRDIGKHFSVNVMLARETVKRRLDSDGISYTEFSYMLLQANDFVQLRRAHGCRLQVGGSDQWGNIIAGVELNRRLDGEQVHALTTPLVTSADGKKFGKSTGGGSLWLDPEMTSPYAWYQYFVNTGDADVIRYLRWFTLLDREELAELETATTERPHAREAQRRLAAEMTTLVHGEAHTRAVQLASQALFGRGDLHDLDEATLGSALAEAAGDGTVAEAGPESTIVDLLVASGLSDSRGAARRAVADGGASVNNARISDPEWVPTDTDYLHGRWLVLRRGKKNFAGARRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H683</accession>
    <name>A0A231H683_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44414">
        <property type="protein sequence ID" value="OXR44414"/>
        <property type="gene ID" value="B7C42_03203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="37318" checksum="BCC4864A19CA493B" modified="2017-10-25" version="1">MLSTAVKNTSADPEYHEILRGLSEGSVHKNFDPYVDIDWDSPEFAVDPTDTRWVMPDEDPLGRHPWYKAQPVERQIAMGMWRQAGIAKVGLDFEQLLIRGLMQYLVSVPNGDPEFRYVTHEAAEECNHTMMFQEMINRIGEDVVGMGTIDRKLTMIIWPAVKYFPELFFTMILGGEEPIDHLQKSLLRAGTDLHPMVQRVMQIHVAEEARHISFAHEYLRRNVPGMNPATKFVLSLLFPTAMRIMLDMIMTPPKEFVEKFDIPAEVMREAYWGSAESQVTMRNIFGDVRALATTSGLMNPVAKVAWRLLGIHGPTSRYRSEPARKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6K2</accession>
    <name>A0A231H6K2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ECF RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sigJ_6</name>
        <name evidence="10" type="ORF">B7C42_03907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44346">
        <property type="protein sequence ID" value="OXR44346"/>
        <property type="gene ID" value="B7C42_03907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="124"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="9">
        <location>
            <begin position="193"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="312" mass="34300" checksum="B9C926B83AA1A6A6" modified="2017-10-25" version="1">MDGEAEDAGAVTARPADPPADPGDAFDTHRRLLFATAYQLLGSVADAEDVLQDAWLKWHEADRDRVRHPKAYLVRTVTNLSLNRLTSARAVRETYVGPWLPEPLLSEPDATERVEIVDTVSTAMLVVLETLGPVERAVFVLRDVFGFSPAEIAGFLDRPEPTVRQISHRARNHVQARRPRYDTDPVARQEITEQFLAAANGGDVNALMQLLAPDVTLWNDGGGKVTAARRPLHGPDHVARWLLGVLAKPILTGIRMRAAVLNGELSVVGEIGGFPVGALTFDILDGRVQNLRFQVNPDKLAGLRPPQEIRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6M3</accession>
    <name>A0A231H6M3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase-binding transcription factor CarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carD</name>
        <name evidence="2" type="ORF">B7C42_03231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019931623.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44442">
        <property type="protein sequence ID" value="OXR44442"/>
        <property type="gene ID" value="B7C42_03231"/>
    </dbReference>
    <dbReference type="GeneID" id="66718574"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="17917" checksum="001004B6CCBDD50E" modified="2017-10-25" version="1">MIFKVGDTVVYPHHGAALIEAIETRTIKGVQKEYLVLKVAQGDLTVRVPAENAEYVGVRDVVGQEGLDRVFQVLRAPHTEEPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRREQDRGLSAGEKRMLAKARQILVGELALAEGTDDVKAETLLDEVLAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H701</accession>
    <name>A0A231H701_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enoyl-CoA hydratase echA8</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">echA8_7</name>
        <name evidence="1" type="ORF">B7C42_03422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776115.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44628">
        <property type="protein sequence ID" value="OXR44628"/>
        <property type="gene ID" value="B7C42_03422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="25690" checksum="6888274BE4356AB5" modified="2017-10-25" version="1">MSVTLSRIGAVGVLTLDRPPVNAFDEAQAGEFATAVTELGADPEVRAVVVRSAAKVFCAGADIAMMDSWRELPDRGVRLEKFCLLLQDAFAALAALGKPTIAEIGGAATGGGFELALACDFRVARATAKIGLPEVGIGLLPGAGGTQRLTRLVGPAVAYRLILGAELIDGTTAERLGLVHRAVEDPAATALTLAGRLADLPAHAYTAAKRCIDATGTGAGYALERTEIRALIHTEETGRRLDEFVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H889</accession>
    <name>A0A231H889_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YtcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytcD_6</name>
        <name evidence="2" type="ORF">B7C42_02903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44946">
        <property type="protein sequence ID" value="OXR44946"/>
        <property type="gene ID" value="B7C42_02903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="10177" checksum="3A9DEE3FD07E2F93" modified="2017-10-25" version="1">MELLGQRWMLRVVWELAPGPLGFLELRRRMDNCSSSMLSVRLQALQGAGVIVKRADKAYELSTAGIELVRALEPLWAWATDHLDPDATVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8G1</accession>
    <name>A0A231H8G1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780058.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45125">
        <property type="protein sequence ID" value="OXR45125"/>
        <property type="gene ID" value="B7C42_03082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8313" checksum="4635F5DCAB9ED44A" modified="2017-10-25" version="1">MSLTTRVLGIARPPSGVLAVDRIACTGHGICAHVLPEQIVLDEWGYPVLTDAEPDPALATEAIGLCPAAALRWVRLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8I8</accession>
    <name>A0A231H8I8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TetR_C_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45169">
        <property type="protein sequence ID" value="OXR45169"/>
        <property type="gene ID" value="B7C42_03127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_16" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="6923" checksum="09F5FDEA727BF379" modified="2017-10-25" version="1">MQAMVRSAFTNANAAETLHEFLSARVLGKLTDGLESDRPDLRTTLASAQLLARQLYFVVLRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8P9</accession>
    <name>A0A231H8P9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative enoyl-CoA hydratase echA8</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">echA8_6</name>
        <name evidence="6" type="ORF">B7C42_02325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45200">
        <property type="protein sequence ID" value="OXR45200"/>
        <property type="gene ID" value="B7C42_02325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="27713" checksum="E8EFF7A6786D503A" modified="2017-10-25" version="1">MTDFETILLERTGRVAVITLNRPKALNALNTQVLTDLTAALDEVEADAGIGAVVLTGSEKAFAAGADIKEMQSKSYMDMFLADFFQGWDRVGAFRKPIIAAVAGYALGGGCELAMMCDILIAADTAKFGQPEIKLGVIPGMGGSQRLTRAVGKAKAMDLILTGRNMDAEEAERAGLVARVVPAADLLSTAREVAETIAGMSLPSVMIAKEAVNRSYETTLTEGLRFERRVFHSLFATEDQTEGMTAFVEKRAANFEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8T2</accession>
    <name>A0A231H8T2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45230">
        <property type="protein sequence ID" value="OXR45230"/>
        <property type="gene ID" value="B7C42_02355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218054" description="4HBT domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="18692" checksum="EAE5FFA2307A206D" modified="2017-10-25" version="1">MVTRAAASARVAPVAVTIVGAVTTQQDYPVLWPVPTRWADNDHYGHVNNVTYYSYFDTAVNAWLMAATGTDIRELPAIGVVAQTSCQYLGSLSFPDQLRVGLRISRLGRSSITYDLAIFRVLDAGTAADTAGEDLELAATGTFVHVYVDNETRKSVEIPAIIRGAAAALVTDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8V4</accession>
    <name>A0A231H8V4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45232">
        <property type="protein sequence ID" value="OXR45232"/>
        <property type="gene ID" value="B7C42_02357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="DUF2075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="267"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="631" mass="70582" checksum="DA3BCA8DE32A5B3F" modified="2017-10-25" version="1">MLLGGVVVSYRVYRSTAEEVLHLSVEQQLSAIVSEHLGRTKRKVPTAEQRSWDVSLPWIAGDLVATGLVHVEMLIEYRLPETSRRADVILSGIHPQTGDDHYVVVELKQWGRAELIWNSDRIVRVQGLPGEHLHPIDQVRGYCRYLTRFVETLHDRPNAVRGVAYLHNATENSVSALRALPPDETGRMFTGEQREEFLTFLKSQFAPESGTGAANRLLESPIRAKPNLFGFTGAELRSATEYSLLDHQKLAYETVMSRVRLARQTDQKSVVVVTGGPGSGKSLIAVSLLAELHREGYRVRHATGSLAFTESLRKFPGKGSRELQDLFKYFRNFSDCEKNELDVLICDEAHRIREVSTNRFTPRAQRTNRPQVDELMAAARVPVFLLDEHQVVRPDEVGTVHAIRDHAARAGYVVHQIELDGQYRCGGSAEYDEWVRRLLGLRIGGPTPWTGDSAAFDVRIAETPQEMETFLRDKNADGWTARIAAGYCWPWSSPKKDGTLVDDVVIGEWAKPWNLRGERAVGGAPPSSLWATDPRGFEQVGCVYTAQGFEYDWSGVIIGPDLVIRDGHLATVRDATKDKALKGTKTKPVGDETFDTLVRNIYKVLLTRGMRGVVIHSVDPDTQAFLKSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Y6</accession>
    <name>A0A231H8Y6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45318">
        <property type="protein sequence ID" value="OXR45318"/>
        <property type="gene ID" value="B7C42_02443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="32584" checksum="920577C5EF42BDEB" modified="2017-10-25" version="1">MSEYGSTLPRRQLGRYLRNGREECGLTLHQAAALIQRSASTLQRIEHGMVAQLREVDIDALCKIYDFEGDAVLAMKALAVQGKELSWWCEYGDVIPENFDFYVGLEASARSLKTYEPERVPGLLQTPAYAGAMCSTAHPEDTAEEHARRVQLRMRRQTRITRKYQPAVLDVILRESALRCVVGGPKVMSAQLKHLADVSCLPNVSVQVLPDRAGFPLGEAVGSFVILDFGKDRGGQLAEPPVVYVEGFIGDMYLEKPVAVQRYHQAYEGLRQSVMDPVASRSLLRQIAKEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H912</accession>
    <name>A0A231H912_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper-sensing transcriptional repressor RicR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ricR</name>
        <name evidence="5" type="ORF">B7C42_02569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45444">
        <property type="protein sequence ID" value="OXR45444"/>
        <property type="gene ID" value="B7C42_02569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13849" checksum="D008F449BF29F8F0" modified="2017-10-25" version="1">MNHQGGSEEQPVSEDQINTVRTAEAAAEPGHDHATHGYITAKDDYLKRLRRIEGQARGLQRMVEEEKYCIDILTQVSAMTKALQAVAMGLLEDHISHCVVDAAVQGGPEADAKIKEATDAIARLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H999</accession>
    <name>A0A231H999_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase 2 membrane subunit SdhC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sdhC</name>
        <name evidence="9" type="ORF">B7C42_02431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051024341.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45306">
        <property type="protein sequence ID" value="OXR45306"/>
        <property type="gene ID" value="B7C42_02431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="15290" checksum="B5D818190BE14E8C" modified="2017-10-25" version="1">MTTTLEAPAQPKRKTLYRGDPGMWSWAMHRITGVTIFFFLFVHVLDTALVRVSPDTYDRAIETYKNPVVALMEMGLVVCVLFHALNGVRVILVDFWSKGPKYQRLMLWIVLTIWVLVSAAGVGRQFFYLLTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9C8</accession>
    <name>A0A231H9C8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45402">
        <property type="protein sequence ID" value="OXR45402"/>
        <property type="gene ID" value="B7C42_02527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20174" checksum="37420476C073A3A7" modified="2017-10-25" version="1">MTDNTPPPITPALRKAAAERPGGWVYVIDPFFPQDGNVPPYGIEGAWKVDDEGKISGEFQRNAKYRPSPVKLGMPKPGDDIERHLQLAATGYGTEESLTNALRSSDVYIPGDGTAETVIYSDSQGDFVALYTRPEIVPENYRFIERVPFETLLHRLPGDAAVVVNPGTPSSVRIPVAALIQGGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9D2</accession>
    <name>A0A231H9D2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ESX-5 secretion system protein EccE5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eccE5</name>
        <name evidence="6" type="ORF">B7C42_02565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45440">
        <property type="protein sequence ID" value="OXR45440"/>
        <property type="gene ID" value="B7C42_02565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03923">
        <property type="entry name" value="T7SS_EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="558" mass="59388" checksum="745FE8B266872EED" modified="2017-10-25" version="1">MAESSGTNSRPLLGRISLPNLLAAQLLGLVVGLVVLAVGVPGWYALAAAVVAGLVLLVPIGKRTIASWIATVWRYVTRQDYDLGDTVDFRGPDGRSLGLYWEGSRVVAVVEVLPPKGGLTRIDRNTVHASHLLPLPELAQCLSQHDILLSGIDIISHGHRSRSGTPAGPIYESLLGPLPATAHRTVWLAISFDALACPEAAARRGGGTEGAGRAVTIATQRIVRALEDADCASRVLTAPEIRKAVWQISAGVDPRALTHRWRYAELGNSVNIGAAVDPKQLGSDLLAQLWVAPSRGTTVAVRLRPGSTPETVNIGAAWRLTARELPEKTKRKGMVSLSGRHRQSLLAHLPIAIPGVDDTVPMGQYPIDVVGVLHLPSSGCGQLIGSDEDGNGVAVRLVGQGISTVYVAGELYLAQQLVFRALAVGERILIRTDRPHAWEQLVTTIGNPERLTIAVETHQSDAGFTAAVVDGVLAPAPHAGVTTIYVTGDPMGWPATNPDLSIHQPGAIGNHVVMRTGTTQVDLTLVSIPRETTYIGNPRGRRPMPQQDPRQRMAQAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9M1</accession>
    <name>A0A231H9M1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimodular nonribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dhbF_2</name>
        <name evidence="7" type="ORF">B7C42_02655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45530">
        <property type="protein sequence ID" value="OXR45530"/>
        <property type="gene ID" value="B7C42_02655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="457"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="565" mass="58605" checksum="6A78046433386B83" modified="2017-10-25" version="1">MSDSPVPNTTAPAASAPETAAAATQSRTGGRGIPLSPAQQAALLPERLRGVAAPNLFLALEITGDIDPADLDRAAVAAVSRHDILRTVYPDDRRIPYQRVVDAPDTVVETVETASADLDAALRSDAAHRIDPVRELPIRIRLHRTPDRDVLSLTAHPVAADDRSLELLVAELLEGSVAEPAAQYRGYAMAQMKSLVGDAAADPDLGYWLDRLADLPERATVAVAGASGAQPGPAAATRTLWVPAAAFGDHDVELSVVAALAAVLGAAGLGDDVPIGIADAGRAGAQEDSALGAYANHLVLRIDTAAAATPRALLAQVAELAVPARAHAAARIERITHQLRGAAAVAAGAPFQALVTTRTEVTGANAREIARRVARPHGTDVVADVVTGAEEVAVTLEFPAAFAGSAEFDALTSGIERWLLNFAAASENPLREVELPTVFERDAFYHGGTGLGGEPSTDAERLIADTIREVLELDADDEVGRADTFFSLGGDSIAALRMVTLLGERGYALDVQKVFEFPAVHELAAQLTEAEAAPAAEQTAPVAPMSASGLDPAALAALGKKFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA43</accession>
    <name>A0A231HA43_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidinol-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisN_1</name>
        <name evidence="1" type="ORF">B7C42_02003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45711">
        <property type="protein sequence ID" value="OXR45711"/>
        <property type="gene ID" value="B7C42_02003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28747" checksum="9A2188705EA463B3" modified="2017-10-25" version="1">MVHDHLDDDLRFAHVLADSADAATMDRFKGLDRAVRARPDLAAVTDAENAVEKLVRGQLRRSRPRDAVLGAGDGLEGGGPRCWVVDAITGLENYVRGVPVWATQISLLEVSAGGYRPIVGVVSAPALARRWWAAKDHGAFTGRSLTSASRLRVSGVSHLTDASFAYSTVTAWEEDGRLNNFLALSRDVWRTRAYGEFWSYMMLAEGAIDSCADPRLSPGDMAANAVIVTEAGGTFTGFDGTPSPLSGCAVASNGLLHNELLEYLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAI0</accession>
    <name>A0A231HAI0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhpC_2</name>
        <name evidence="2" type="ORF">B7C42_02162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.14" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45870">
        <property type="protein sequence ID" value="OXR45870"/>
        <property type="gene ID" value="B7C42_02162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052823">
        <property type="term" value="F:2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018771">
        <property type="term" value="F:2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="31366" checksum="6FADA97E7E0430A8" modified="2017-10-25" version="1">MPIAEIRGGEVYYEILGESGPLIVLTPGGRFSIDIPGLRPLAEALVAGGHRVLLWDRPNCGRSEVAFWGPTESHMRAEVLHDLLVHLDTGPVIIAGGSGGARDSILTAMLYPEIATKLIVWNIVGGNYGLIALGSHYIIPNITAAKITGIEGLIELPEWQERIQDNPKNKDRLLALDADEFQAQMLRWLDAYVPKPGQTIPGVADYEFSKLRIPTLIIRGGEHDIDHPKRTSMEVHCLIEGSVLIDPPWPEDAWQQGQKARARGEGNIFDTWVLAAPAILDFVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAN9</accession>
    <name>A0A231HAN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="2">1.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acr1_2</name>
        <name evidence="2" type="ORF">B7C42_02197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45905">
        <property type="protein sequence ID" value="OXR45905"/>
        <property type="gene ID" value="B7C42_02197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="35200" checksum="5E67F9C966C1D019" modified="2017-10-25" version="1">MSAQSPVVVVTGASAGIGRATARRFAADGARVALLARGRAGLDAAAKDVEQAGGEALPIPTDVADHDAVEAAADRVEQQWGPIDVWVNSAFTSVFAPFTEIEPEEFRRVTEVTYLGSVHGVMVALARMRPRNRGTIVQVGSALGERAIPLQSAYCGAKHAVNGFLEAVRVELMHERSGVHVTIVQAPAVNTPQFSWVRSRLPKKPQPVPPIYQPEVVADTIAFAAEHPGRKQYWVGASTVGTVVAQRLAPAVLDRYLARTGYDSQQTDAEETDRPDNLWRPLDDEHGHDFGAHGDFDGRAHRHSPQAWMSRCAESVAGSVARMARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAU4</accession>
    <name>A0A231HAU4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Modulator of FtsH protease HflK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflK_1</name>
        <name evidence="5" type="ORF">B7C42_02242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778790.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45949">
        <property type="protein sequence ID" value="OXR45949"/>
        <property type="gene ID" value="B7C42_02242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011291950" evidence="3">
        <location>
            <begin position="31"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="414" mass="44775" checksum="F50C7FA8F784156B" modified="2017-10-25" version="1">MAVLIVAIVIVVLVAVVVFKSIALVPQAEAAVIERLGRYSRTVSGQLTFLVPFADRIRAKVDLRERVVSFPPQPVITQDNLTVQIDSVVYFQVTSPQAAVYEISNYIAAVEQLTITTLRNVVGGMTLEETLTSRDQINSQLRGVLDEATGRWGLRVARVELKAIDPPPSIQESMEKQMKADREKRAMILTAEGNREAQIKTAEGAKQSQILAAEGSKQSAILSAEGERQSRILRAQGERAAAYLQAQGQAKAIEKVFAAIKSGKPTPELLAYQYMQTLPLVAKGDANKVWMVPSDFGKALEGFARNFGTQGEDGVFRYEPSDDGAAGTPDDDADEVADWFDIKTDPAAERAVRAAEAAAATPVDSPLVAPNQPRHLPPQSAPIPPSPPAQQQQPAPRPGDAGGRPWQPPEYPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAV9</accession>
    <name>A0A231HAV9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cysK</name>
        <name evidence="6" type="ORF">B7C42_02284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45991">
        <property type="protein sequence ID" value="OXR45991"/>
        <property type="gene ID" value="B7C42_02284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="346"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="442" mass="47724" checksum="03B5544FBB5496B8" modified="2017-10-25" version="1">MRYDDITDLIGDTPLLRLDPAVHRLPGVELYAKLEFYNPFGSVKDRVAWGMIRDELDEITARGQTLIEASSGNTAKALRLLGARHGVGLHAVTNRIKVGEVRDLLQLFGTRIEELPGLSECPDPTTPNDVYSVIETTMAKNPGAYHHPSQYTNEKNIDAHYHGTGREIHEDLAAAGVGADYLIGGLGTTGSTRGTATYLRKHHPELRTVAVVSQRGDFIPGIRSETEMWDVGLFQPEFYDRIVTIDAARAIEATLELATGYGILAGPTSGAGYAAALEVLADLPPRPAPIVAVLIVCDRIEPYLSYIKKRRPDLFGRTGSAVPALTDAELGSVRELSPGELRELDATARPTIVDTRGAMAYRIGHIPGAINIRDDQLDDMFAHGVPFSRSRPLVFVCPVGDLSRRFAAAAARAGYDAASLAGGIVAWRDAGFDLESAAPPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAY4</accession>
    <name>A0A231HAY4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase LipF</fullName>
            <ecNumber evidence="3">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lipF_2</name>
        <name evidence="3" type="ORF">B7C42_02179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45887">
        <property type="protein sequence ID" value="OXR45887"/>
        <property type="gene ID" value="B7C42_02179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="99"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="339" mass="35568" checksum="3B9BDC8A8BE6F61A" modified="2017-10-25" version="1">METRRSTETSPSATAPVPSSPSLRARLALTAGRYGVRPINCLLPANPLGIAAARGLVASIMALCGPVLPGTHVTQVRSGSLRGEWVRAAGVAHGDRALYYVHGSGYVICSARTHRGLASRLSRATGLPVFVVDYRLAPEHPFPAAADDVAEGYRWLLAHGYRAADLVIGGDSAGGHLCMDLLLDNARTGRAQPAGAVLFSPLIDLSFELARNCERRATEAMASARTGRAAVRLYTGDEPGDSPRLRLRIPAGIALPPLFVQVSGAEMLADDAHHLRDLARAAGVPCELEVWPGQIHVFQALPLAVPEAGAALRRAAAFITGVLARSPAAQPVSSAREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB03</accession>
    <name>A0A231HB03_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-talarate/galactarate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.156</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.156" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45907">
        <property type="protein sequence ID" value="OXR45907"/>
        <property type="gene ID" value="B7C42_02199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="143"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="38897" checksum="501B1BDA5F2D4713" modified="2017-10-25" version="1">MTATIDEAVRVGVYRFPTPEPEADGTLRWEATTAVTVEIDAGGQTGLGWTYSGGATAAIVREVLAPVLAGRSPFDIGDCRIRMQRACRNLGTAAVVAHALSAVDIALWDLKARLLDVPLSRLFGAVRPATPVYGSGGFTTLTDDELGEQIDGWLSAGCRDVKIKIGEDRGERTDRDLERVSFANGLLGDRAHLMVDANGAYSTALARRVGTELDRHGVIWFEEPVTSDDPSGLALLRAALRCDVTAGEYVYRHYDAAALIGSVDCLQLDVTRCGGYSGFVECAALAAAHGLDISAHCAPALHAPIVSSFAHLRHVEWFIDHSRLEPLLADGVPEVRDGALAAGRGAGHGMRLAGSAGKYSVEGAGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBJ7</accession>
    <name>A0A231HBJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46241">
        <property type="protein sequence ID" value="OXR46241"/>
        <property type="gene ID" value="B7C42_01207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022566">
        <property type="entry name" value="DUF2613"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11021">
        <property type="entry name" value="DUF2613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="56" mass="5634" checksum="F26ADD95844F2320" modified="2017-10-25" version="1">MKFAVPGVASAVAGALLGVIAVFVVVTATAQNSRPEVDRSGDASSSLLNNVEYGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC73</accession>
    <name>A0A231HC73_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">sn-glycerol-3-phosphate-binding periplasmic protein UgpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ugpB</name>
        <name evidence="2" type="ORF">B7C42_01388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46422">
        <property type="protein sequence ID" value="OXR46422"/>
        <property type="gene ID" value="B7C42_01388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013302759" evidence="1">
        <location>
            <begin position="36"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="439" mass="47979" checksum="E042F8BFB9E6410A" modified="2017-10-25" version="1">MTRPRTLTRRGFLTATSAAAGLALSACAGMGGSTGAGGDPKTIIFWSNHPGTSKNQETELINRFHAQHPDLTVKLVDAGRNYEEVAQKFNAALTGGALPDVVVLSDVWWFNYALNKAIEPLDEHIAAAAVPLADYVDSFVDDYRFAGRLWALPYARSTQIFCYNRGLWARAGLPDRGPQSWQEFDEWGPELQRAIGAGKWAHGWGDAKNYLAWTFQGPNWTFGGAYSDRWTLKFSDPHTVEAGNFLRDMINRKHYAAIRPQLAVDFGTGVVGSAITSTGDIKGIVANAAGKLDFATAFLPHPNGPGCTTGGAGLAIPSRISDQRKANALRFIEFITNPVNTAYFSQATGYIPVRKSAVHDPSEQQFLAANRNFATAVDQLPLTRSQDYARVFLPGADQIIGTGLEQIGLQNREVTSAFADITDRLQTIYDRQIEPKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCD4</accession>
    <name>A0A231HCD4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041738.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46550">
        <property type="protein sequence ID" value="OXR46550"/>
        <property type="gene ID" value="B7C42_01520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12137" checksum="22BA4EB8351B8B1E" modified="2017-10-25" version="1">MTIYQRLDPIDRATALDMINSGVSERAGEAILRLALHDSDSAWVTDRALELLANSDWRIRAVAATALGHLARLHGSIDKERVVPALRVLLDDRATAGRAEDALDDITMFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCU1</accession>
    <name>A0A231HCU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46659">
        <property type="protein sequence ID" value="OXR46659"/>
        <property type="gene ID" value="B7C42_01634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="235" mass="23748" checksum="802E61F855B13772" modified="2017-10-25" version="1">MSRHRFLIREFAEFLEGGNVAIKHAGPIPIWAGFIIEQNARIIEILENLTMTDQTQFQAEYAQLVQINTDVKSILSDANTKVADLQAQVDALKAKAGDGSITPDDLNNFASALNDLQSTVTSAHATSSTGPSTGAPSAPVDAQQPIVGAPADTGTTQATTDTGAALPDPNAGAAASVPAQQPIVPGDTSAPATSATTPADATDGGKVSGADEPTTTATTTATDGSTAADGTGYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCX6</accession>
    <name>A0A231HCX6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46770">
        <property type="protein sequence ID" value="OXR46770"/>
        <property type="gene ID" value="B7C42_01748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="81" mass="8699" checksum="B5724FF076AF49A7" modified="2017-10-25" version="1">MTSDSAGPRWVKSSYSQGGGDCVEVAYLGEHTVGVRDSKDRTGPTLVFTPAEWDTFTTALVAGQFEGSTAWGLQARRSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD82</accession>
    <name>A0A231HD82_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">acpS</name>
        <name evidence="10" type="ORF">B7C42_00005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517926.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46891">
        <property type="protein sequence ID" value="OXR46891"/>
        <property type="gene ID" value="B7C42_00005"/>
    </dbReference>
    <dbReference type="GeneID" id="66721133"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="15488" checksum="8A762E8236F2EE90" modified="2017-10-25" version="1">MTILGIGLDLVTISDFAEQLERAGTTMLRESFTAGERRYCQSKGTDPARSFAARWAAKEAVLKAWATSRFARRPQIGDNPYPLIEVVNDAWGRPSIKLHGLAAEFLPRVRVHLSITHDGDTAAAMVVLEDPGELADLIENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDH9</accession>
    <name>A0A231HDH9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_00096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46980">
        <property type="protein sequence ID" value="OXR46980"/>
        <property type="gene ID" value="B7C42_00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="15348" checksum="48F5FA79AAD5494B" modified="2017-10-25" version="1">MTDDVSVRPEVFAVGSSRRRVVCREISRTQIVQYAGAAGDYSSLHTDEPHAVRAGYRGVMVHGMMVMAATERLLSDWLGRDRLAHYGVRFVSPVWPGDSLEAVATVRAVRDDADGRYVELEVVTTNQDSVAVLAGSAGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDN7</accession>
    <name>A0A231HDN7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor FabR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fabR_1</name>
        <name evidence="5" type="ORF">B7C42_00132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47014">
        <property type="protein sequence ID" value="OXR47014"/>
        <property type="gene ID" value="B7C42_00132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="23268" checksum="C475C46A1991E63B" modified="2017-10-25" version="1">MLSEMSEQAETRVERKERTRRALLDGTLTLAAERGFAALSLREIARSAGIVPTAFYRHFDSLDELGTALVDEGVRQLRLALRHLRRTPDARLAETVRFVFAQIAGREDLYGFLIRERHGGAPALRTAIASEMQLITRELVVDMSRIPALDAWPTDDLELAADLIVSTVADHIADFVAAPLRERPLVVDRTVGQVRMIALGMAAWKPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDW8</accession>
    <name>A0A231HDW8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain type dehydrogenase/reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46976">
        <property type="protein sequence ID" value="OXR46976"/>
        <property type="gene ID" value="B7C42_00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="31286" checksum="AB8877D4987BADA4" modified="2017-10-25" version="1">MGTLDGRVAIVTGAGRGIGGSVAKLFAAEGATVVVNDIGASLNGLASDGSPADELVREIESAGGTAVTNGADISDHEAARDLVESTIERFGKLDILVNVAGILRDRMIFNMTEEEWDAVIRVHLKGHFNTIRPASAHWRKIGDPNAQNRIINYTSRAGLHGAPGQPNYSAAKMGIVGLTYSCAVALKRYGVTANAISPAAATRMTATFKDASAYADGADELSPDNIAPIAAYLASEQSGWCNGHVIHARGYEVSLYSDPQPLVTLRSDGPWDLRLMAKEVEAAFRPSTDAAPPNPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEN0</accession>
    <name>A0A231HEN0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fitB</name>
        <name evidence="6" type="synonym">vapC</name>
        <name evidence="8" type="ORF">B7C42_00307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47185">
        <property type="protein sequence ID" value="OXR47185"/>
        <property type="gene ID" value="B7C42_00307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15689" checksum="49E4887E60B86A68" modified="2017-10-25" version="1">MTFLLDTNVISELRKSARVASPAVRAWVAGRRPSELYLSVVTVMEIELGIGLIERRDAAQGNRLRMWLEDEVLDVFAGRILELDLASARRAARLHVPDPRPERDALIGAIASEHAMTIVTRNTKDFASMGVATLDPWSVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF23</accession>
    <name>A0A231HF23_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispG_1</name>
        <name evidence="4" type="synonym">ispG</name>
        <name evidence="5" type="ORF">B7C42_00696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47571">
        <property type="protein sequence ID" value="OXR47571"/>
        <property type="gene ID" value="B7C42_00696"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="375" mass="39592" checksum="0C895C3AC94F6068" modified="2017-10-25" version="1">MTAVFLSEPAAPTLRPRRESRRIDVGSVPVGGGAPISVQSMTTTVTADVEATLRQIAELTAAGCDIVRVAVPTQDDCAALPTIARRSAIPVIADIHFNPRYVFAAIDAGCAGVRVNPGNIRTFDDKVREIAAAAGAARVPIRIGVNAGSLDRRILDRHGGRATASALVESALWEAGLFEEHGFTALKISVKHNDPLTMIRAYRLLAQRCDYPLHLGVTEAGPPLQGTAKSATAFGILLSEGIGDTIRVSLSAPPVEEVAVGHHILAGLGLRPRTLDIVSCPTCGRCQVDVFELTKKVEAAFRDFPAPLRVAVMGCIVNGPGESREADIGVSAGNHKGQIFVRGEVVRTVPESMIVEALLEEALTLIEDAPETQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF66</accession>
    <name>A0A231HF66_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47524">
        <property type="protein sequence ID" value="OXR47524"/>
        <property type="gene ID" value="B7C42_00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="320" mass="35454" checksum="82712331CC66415A" modified="2017-10-25" version="1">MRRWFDDAILAEGRLPLLCFLLGFIVGFLLIRLSVRMIRKQVRWWPGNLRAGNVHIHHMVFGVVLVLTSGLGMVATYNSGVGTISALASTFGVGAALVLDEFALIYYLRDVYWEEQGRTSVDAVFVAVAVTGLLLLGFHPLWLLDINDIRHDGSVAGRSFLGIFALVNLVLAAIVIAKGKIWTGLFGMFFLPLLVVGALRLSRPGAPWARWRYGERRRLMYRAVVRERRYRRPVIRAKIFVQDLVAGKPDVAHVRSAAEEELARTVVPAPPAHLRTRAMRASMHEVPVRTSSADTSPPADTPRPADVDGLTAAHPQHSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF76</accession>
    <name>A0A231HF76_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47376">
        <property type="protein sequence ID" value="OXR47376"/>
        <property type="gene ID" value="B7C42_00499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="18748" checksum="82415FC2BAF1B671" modified="2017-10-25" version="1">MDQWDMRVRIRRARPEDFAAIAQLTVDTYVGEGHVHPESPYVAELSDTATRAREAEVLVAERDEDLLGSLTIARPGTPYADIARAGELEFRMLAVAKRARGAGVGTALVRTVVETARAESFAAVVLTTMPAMADARRIYERMGFGHVPERDWRTDAGLPLTVMRLALTPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFA6</accession>
    <name>A0A231HFA6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47406">
        <property type="protein sequence ID" value="OXR47406"/>
        <property type="gene ID" value="B7C42_00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="506" mass="53494" checksum="FB3819F5F761253D" modified="2017-10-25" version="1">MADAVPPGLELLHEGAAAHARGDVTEALRIFERAAHTTSGGVRVSALVNAASMRDELGDHAGAITGFRAALTEIPDDATEKRASTLVNYSQALQHVGDLDAAQTALEQARDLLIGHNELSTLRVSCLISLTAVAMHRSQWARAIELGTESLEFTTRFAAPLRGHPLANLAAAHFESGRGELGLDFAHQALTAFDAAGDGNGAAETQQTLAMMYARLGRSDEAEPYLSASQQYFEQAGLGYRAGLGLQLMAYLGERHGDLDHVGQLYRRALTSFEQSGAALESAGVRIRLATLDFAHGRVGDGQAQLAAAYEIYAVRGLGLQCARVDYWHAALWDSVIADMVTPPPAEVLALARDLAVTSALAIDAVRYSFANGTQREQWNREIAAPAVRLAFRFAHLCGNGELIADLIETVCAGTAFDTAAATESGPPRLPFDPGPTPDDALDLPDAGSLQLGSALAQVAAAAGLPVSPPPRLSASPDGHIALDTYIAAAEQRYGRPIRDDRVLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFG2</accession>
    <name>A0A231HFG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretory immunoglobulin A-binding protein EsiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">esiB</name>
        <name evidence="2" type="ORF">B7C42_00538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47415">
        <property type="protein sequence ID" value="OXR47415"/>
        <property type="gene ID" value="B7C42_00538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012963453" evidence="1">
        <location>
            <begin position="23"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="567" mass="60702" checksum="CE893F4D824F9688" modified="2017-10-25" version="1">MDFVISLVLSAIASSSSKDAVAQHVTDADGDLKRLIAERYPDVDVSALERKPDSEAKRASLAEDLDDAGAAGDRALASAAVNVMRAVHRPEAAPPELPGTALAGAEESTGSDAAALFGGAVAAEDTGRTQEAEALYRRAADKEHPGAMNNLGLLLEDTGRSPEAEEWFRRAADLGNANAMSNLGVRLRDAGQVADAEGWFRRAADLGHARAMNNLALLLEATERSECADEWFRKAADAGHTGAMNALGVRLEARGQVEEGEAWYRRAADTGDPNAMFNLGLLLEDAGKVEPAELWIRRAADAGHATAMFNLGVLADDSGRKPEAEAWWRKAADAGHPKAIFNLAITLEEAGRSEDAETWYRRAADAGHPASMFNLACALQEAGRRREAEALYRKAADAGNVTAMFDLGALLEAFGEVAEAESWYRKAAEAGEAVAMTNLGALLMESGRPEEAEWWYRKAAEAGRPVAMCNLAVAMEKTGRMTEAEAWYRRAAESDHSRAMFLLGGILEHRGRTDEAETWWRRAADAGHPGAMSGLAYLLALAGRVDAAETWRRRAAAAGDPGPTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFI4</accession>
    <name>A0A231HFI4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779563.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47642">
        <property type="protein sequence ID" value="OXR47642"/>
        <property type="gene ID" value="B7C42_00767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="36297" checksum="B90308451153D162" modified="2017-10-25" version="1">MAVSDIHVGHQGNKPVVEQIRADSPEDWLIVAGDVGEKTDDIRWALRTLRERFAKVIWVPGNHELWTTTKDPVQIKGAPRYDYLVALCRDLDVVTPEDEFPVWEGAGAEQYGGRVTIAPLFILYDYSWMPEGAHTKAEALTIARDRNVVATDEFLLASDPYLTRDAWCRARVQYSKRRLDALEPDTAVVLINHFPMLREPTRMLFYPEFSLWCGTEDTADWHTRYNVVCSVYGHLHIPRTTFYDGVRFEEVSLGYPREWQRRGLPDKLLRQILPAPEYGPDDLNEWGGHFKITPEMRAAAEEMRRLADRRRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFL1</accession>
    <name>A0A231HFL1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein MdtL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mdtL</name>
        <name evidence="7" type="ORF">B7C42_00789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779535.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47664">
        <property type="protein sequence ID" value="OXR47664"/>
        <property type="gene ID" value="B7C42_00789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="401" mass="41102" checksum="F57F1EF3303B1CEF" modified="2017-10-25" version="1">MAATVTVAPAQRTTQSWAYALILVASGVALGVSGVPAPLYGLYQKEWHFSPLTTTIVFAVYAVAALAAVLVSGKISDVVGRKPVLLGALATMVIGLIVFLFADNVAMLLVARALHGVAVGATVVAGAAALLDLRPQHGARSGQLTGVAFNVGMAVAILGSALLAQYVPHPLRTPYVVITVLCLLIGVGVVVMTETHTARMSGPIRIAKPAVPQEIRADFWFSALGVMAAWSVLGVLLSLYPSLAAEKTGVHNVVFGGAVVASTATAGALAQLFATAIPARRAAIGGDTGMAIALLLTIPALATHNWVVVLLAGVLLGTTFGLGFGGSLRHLSNVVPQHKRGETMSAYYLLAYTAMALPTVLAGWAATQWGMGTIFPWFVVVVALACLTAAAIGVRGSRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTA0</accession>
    <name>A0A231GTA0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsK_3</name>
        <name evidence="4" type="ORF">B7C42_08077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000057">
        <property type="protein sequence ID" value="OXR39853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043557.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39853">
        <property type="protein sequence ID" value="OXR39853"/>
        <property type="gene ID" value="B7C42_08077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="1496"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1735" mass="184586" checksum="3E096C0387CB744F" modified="2017-10-25" version="1">MSVMSSEGAATAFARAAAAAIRRELAAPRWGSRRLLLRQLHGLPPAAIFEALLDGVQTRDITVYPDGPGGNGATITSIVADGGTLIIPYLVDTSAATPNSGNEGFAASLRTHFLEGAQERRVLLILAADPQETIASTTDDAATLPAVSFDRLCKAAVLPPPGHPQPSRLLRVVVDDYVTRVQALAGTPTWQDAERLRDWVDRHHDDPDAAVGASLHELGMYVSDPDLTPATAARRLEESASWRQDLDQLVASPGQDLARVLSRRVGAVGIDKVLSAQTVRGTDYAGFTLSDLKDRGARPPVELDAITPVEGARLALQSGSAIALWLPVAGATLKFKLTRPLGRTEQARLWWHGSQRALLPVRGQSAEASVAAPPSGEWRFGWLELLDRGSVTARYQVGAVFSDGDAVAFEDALDIDTEMGGFNCGETPLLTAWDSKGRSLGAVRLDHADDDGDDPVRHVSGWIGSVRVGPVPVIPARADDDDGGGGGGAAGDGEDRGSDRGDGDSGGGAPGDGDEGAGDDGGTDNSGGISGASGDDGSLNGGSAGRGELPAASAEQPTLAHAMLAFRQQEWPGGATAAAGGTLVTGRYGAVRLKVHPRSERTELLPVEQAILAHPEWCMFSVAADGSSCSPMREFPRPEPEWASQLDAFLGARVRYFDAAVRAGSTYALDPRSEVAGDYTAAYRNLLNALPRDATSRAEYDDLLLVDRTEVRGIADALVAPTSPLTVAWHAALADRFSMLAAAGAAVDRADIAAFTPQHLLPVVMSFGDWYEAVPSKTALLWRRYAPLASSNPGALERNATFIASRIRFFLSVHPGLNRPETTVAVTFADADDGSAVVEAVRHFFSPERTLEMYRRPRLRAVIAGGGTEARRAVNSVLAGATSSDLDRIVQTRCDFIVSETASPPEFSDVSFLFRSPGSRGVRPVALDQRAPTTYSRSLCTTPGRIRVPDAEYVFATGTFAAPLSDDATDLEAIQYRSLELVGGQGGERLQPGWTRMVTATAAEADLADWYDQSAWVVHLDRLVGLEAFADADSGRTLLEYEEGADPAYFGYDGITGTRIAVQPYIAALRRALAGVASPRPDEARALMRVLEAVSGRWALQIVQRPLLKVLERTGTACAIRHLASVENALDADGGDSFNALVALEEIVPGFPEAGIPQRLRASRTGRAMCDDLLLLSVQPRGDQAPLVQATVIEVKFSQGGGADYSTAAEQVEETISWLQGRFCDAGELEELRGRDLAELIRSSHTRNTSFGLAPPLPAGAEDSLARISAGDYELDFGHWRRDAYRRGLVIAVEPRLAGPMELTQLNAQLGPIDLVSIRRDAAAAALEMHRLAPPGGWARLRLVPPLASAAGGAQPAAPDSGSGSSPAASPATDTGALSVELMRDAASLDAAFARYALTVEPFDPALAQAGPSVIRFRTRAVGRLSISEVERRSRDISREVGAPGVIGIGDEPGFITVDVPRAQRQPVPMPIALQALDAHDPKPGALSFVAGVAPSGEVRIEDLSRLPHLLVSGATGSGKSVFLRGMLVELLRSRTPEQLRLMIVDPKRLDFAPFTRAPHLERGEIISDPAEALERLRATLEEQIDRRQPILETAGVSSAAEFYESGGSLDELPQLVILVDEFADLVLAGPDRRGFSEMIQRYAQLTRAYGIFLVLATQRPSVDVITGSIKANLSARVAFSLPSVRDSMTILDRGGAEDLLGDGDLLFYRNGKIERLQAPFATLADVRAVLDVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTG7</accession>
    <name>A0A231GTG7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000052">
        <property type="protein sequence ID" value="OXR39909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39909">
        <property type="protein sequence ID" value="OXR39909"/>
        <property type="gene ID" value="B7C42_08014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="25946" checksum="5A9C6C9EB7C4E931" modified="2017-10-25" version="1">MTTVCKCGRNPSPRPLRRGLCPACYMTHRERQKAYGRWTPDRVPADPVRAHLATLKAAGLSYRRIVELAGLHRSYIGTLLVGKNGHPPAQYVSKSTADRILSVPVPADFTEAVSLSADGDRMPALGAQRRLQALVAAGWTMRELARQLGLVSNNFGPLMHGDGTITVARYREVVDLFERLQMQPGPSSRARVYARKRGWKLPLEWDEETIDEPDARPIPRSRRQIRTDRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTK0</accession>
    <name>A0A231GTK0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lipoprotein YerB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yerB_2</name>
        <name evidence="5" type="ORF">B7C42_07964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39957">
        <property type="protein sequence ID" value="OXR39957"/>
        <property type="gene ID" value="B7C42_07964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011240557" evidence="2">
        <location>
            <begin position="34"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048" evidence="3">
        <location>
            <begin position="62"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="4">
        <location>
            <begin position="212"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="34657" checksum="731C1BBF7EDFEED2" modified="2017-10-25" version="1">MRQRWWMWIAAFLTALGMCAVIGCVSGTRPEHAAPGSDTSSRVEGPGTSPQAGGSEAPSQVGAPVLVVKVDNSPQARPPVGLGAADMVYVEPVEGGLSRLAAVFSTNKPPVVGPVRSARETDLTLLAQFGNPTLASSGSAPELIPAIDGSSLQNASADRQPAAYFRDYSREAPHNMFVHPDQLPVGGGWPQASQLHFGPAPAGGRPTQHEETRYSGAVIGFDWSPGDHGWLVSMDGDAYTDADTGRLTASTVVLQSVPVRNSAISDVAGSVSPLAQTTGSGQARVLRDGQEFPAVWSRPSPEAGTTYTTPTGAVIPFAPGQVWTVLVPEQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU48</accession>
    <name>A0A231GU48_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator CdhR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdhR_11</name>
        <name evidence="3" type="ORF">B7C42_07830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40075">
        <property type="protein sequence ID" value="OXR40075"/>
        <property type="gene ID" value="B7C42_07830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="312" mass="33340" checksum="6DD61EE0800B1CE0" modified="2017-10-25" version="1">MHTVAVLALEGVVSFDLAAPIETFTRTRLPDGRPGYQVRVCAEQPEVDAGAFTLRAPWGLAGLADADTIMVPGTADPTAPLSPAVRDALRTAAANGTRIASICSGTFALAATGLLDGLRATTHWIAAAELAAAYPAIEVDPDVLYVDNGQILTSAGAAAALDLCLHMIRRDYGSAVAADTARLSVMPLEREGGQAQFIVHGFAPTPRGSDLEPLLNWLETNLAADLSLDEIAARAGVSTRTLIRRFREHTGTTPLQWLHRARIRRAQHLLESTAHSVERIGAQVGFGSPTAFRERFKRTTGVSPHSYRRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUI1</accession>
    <name>A0A231GUI1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40277">
        <property type="protein sequence ID" value="OXR40277"/>
        <property type="gene ID" value="B7C42_07615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="29382" checksum="A43F4960274E7DEC" modified="2017-10-25" version="1">MDALVVEVEPEPGRFCLAELESGGGFGGVGEADHVRQGDRVGAVGGVDSGAAGVDGRQLFVIADAADGGATGNEKFEQLQPFSIRQFDMFVDDHERLLVHLVDPHRYGGREIVGRPHLVGVVVWSVSVEDVQESVDGLHACAGGFGEDRGGGGLGREAENCSAGCAPGVDEHAHGGGFPGARRCGGDGDAGGGGGEVGDHGGLAGVEFLAVVRRIGVVGGDGGGHETLVDRACAGLHREFRKAVFEIELARGSEVLCAGAGVDAGAVATLNQFGHRGQGGLGNDIGVGACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUT1</accession>
    <name>A0A231GUT1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909911.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40328">
        <property type="protein sequence ID" value="OXR40328"/>
        <property type="gene ID" value="B7C42_07589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="30052" checksum="2CB5196166117E70" modified="2017-10-25" version="1">MHTGRPSDTAAAIAHIRAKYSKLHPEILADPLADRILCEPVLDHTVLDRGLAPDVAHRRGQYILARSRFADDRLAAAVARGVDQIVILGAGLDTTAYRSSHHVRFFEVDHPDTQTWKQRLLAEATIPVPDTVTFVPIDFEHTTLAAELATAGLDRSRPAVYIALGVTVYLTRPALEDMLGYILDHHGGEGVLDYFYPPHHASADHLHTRAESTARLGEPWRSCFTADEFHHLIQSFGGQLLEDHCASELVAAYAGRTEIPSTAAGTHVVHCSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV28</accession>
    <name>A0A231GV28_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40480">
        <property type="protein sequence ID" value="OXR40480"/>
        <property type="gene ID" value="B7C42_07418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="20438" checksum="939555AC98C509A1" modified="2017-10-25" version="1">MSSSSANRPARLNRALLALIGLALILAGAYAILAYAGVLHWVDRDAPLVPGTAEPSQWVFVAVVAGAVVVGLAALRWLAAQFARLPARMRWHIGTVGNSGETLMDSNVAAAPVATDIESYPEVRSAQARLSGPGRAPELHLVVTAEPDADLTALRRRILSDAVGRLRQALEVDAVPVSLELRLADRGRTARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVA1</accession>
    <name>A0A231GVA1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40502">
        <property type="protein sequence ID" value="OXR40502"/>
        <property type="gene ID" value="B7C42_07441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="11081" checksum="41B1BE8C061C4AB4" modified="2017-10-25" version="1">MAGPNDRFKVDLELLDEAVSVMGTFGTDVDSWLEDVDRHIAELHLSWDSQAAAAQRAAHDEWAAGVREMRENLDDLRAIAQKAHGNYSTAVDTNTRMWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVX9</accession>
    <name>A0A231GVX9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ssuD_6</name>
        <name evidence="2" type="ORF">B7C42_07204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40780">
        <property type="protein sequence ID" value="OXR40780"/>
        <property type="gene ID" value="B7C42_07204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019923">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03621">
        <property type="entry name" value="F420_MSMEG_2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="284" mass="31322" checksum="F8CE89F8E1F13DF5" modified="2017-10-25" version="1">MREFRFGVNFLNPGSADEWAAKCRRAESLGYDVLLVPDHLELPAPFPSVLAAAQAAERPRVGTFVLNAAFWNPVLLARDVVSTDRLTGGRLELGLGTGYVRDEFEEAGIDFGTPRSRVDHLEKTLTELRRLLPEPHPTILLGGSGNRMLRLAARHADIIAFTGGESVPGATDGSMRLSSAETVDDRVAAARRFVTEYDRDPEFNILVQQVVETTDRTAAATEIAAQMDHLSVVEVLDAPTLLIGTPAEMADQVRERRERYGFSYVTVLEPAMEAFAKVMREVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW19</accession>
    <name>A0A231GW19_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780135.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40819">
        <property type="protein sequence ID" value="OXR40819"/>
        <property type="gene ID" value="B7C42_07103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="9318" checksum="0C16C0B065FE2A86" modified="2017-10-25" version="1">MLFDIRTIVGALLGCYGLILVVTSLVHDTAAERVRTGGWNINLWAGVGMLVAAAAFLLWVVLRPVRELTESEPEQSETDTPGGPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW52</accession>
    <name>A0A231GW52_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 107B1</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40863">
        <property type="protein sequence ID" value="OXR40863"/>
        <property type="gene ID" value="B7C42_06998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="45620" checksum="103FBB3957CC490F" modified="2017-10-25" version="1">MSTTASFDITSPAFKHAPFEILADLRKDSPIAKIALPGGESGWLVTRYDDVEAFFRDSRLTNNPADVYPPEVLAMVFPHGEFSDALLHSVIFQSDPVHHARLRRLVSASFTPRFIETWQPRIQQITEALIDRLPGHGEIDFVQEIAFPLPMQVISEILGVPTADQEKFRIWSNLYVDAMGNPAAAMQIKDEMQEFLHYLHALLEAKQQQPAPDLLSRLLQVELEGDRLSRKEIIGMAQLLILAGNETTTALLSSAMLTFFQHPEQAEAVKSDPALLKQAIEEVIRYRGPLMNANDRWVAEDFEHQGQQLKKGDHIYLCVTSANRDESRFPDAATFDIRREDSQRHLGFGKGMHFCLGAPLARLEASVGLSTVLRRMPDIALAVGMDEITWRPGITSSTLEKLPVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW94</accession>
    <name>A0A231GW94_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ssuD_5</name>
        <name evidence="2" type="ORF">B7C42_07032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783819.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40897">
        <property type="protein sequence ID" value="OXR40897"/>
        <property type="gene ID" value="B7C42_07032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="38788" checksum="9E18B37DE36ACCE0" modified="2017-10-25" version="1">MSAEFLWYIPNQVTPGHRGDTVTTDHNSLDTLTAQARALEEYGWKGALLGTGWGRPDTLTVAAALAARTQSFEPLIAIRPGYWRPAHFASAVATLDHLSGGRVRINIVSGKDNLAAYGESEEDQAARYGRTEEFIRLVRRLWTEENVTHAGTHYRVTDSTVLPRIPAREGRPHPTLYFGGASAAAERVAATVADVQLFWGEPLADVRERIERLRELSEQHGRELPPLEFGLRVTTVVRDTTEQAWADAQARVAEMAKNHEAGPGPQWRAAVGQQRLYDLAARGDVLDDNLYTAPGRVGGGGAGSTWLVGSAEDVAKSLRKYQDLGITHFVLSDTPYLQEIHRQGEQLLPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWA0</accession>
    <name>A0A231GWA0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gdh_3</name>
        <name evidence="3" type="ORF">B7C42_07126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40842">
        <property type="protein sequence ID" value="OXR40842"/>
        <property type="gene ID" value="B7C42_07126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036761">
        <property type="entry name" value="GDH_Mll4104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1638" mass="178535" checksum="E3C68D1719A4EE4F" modified="2017-10-25" version="1">MVATTQQTISWKRFRDDPTDLEAVYFRWIQPGAAAPTITDRAEQIFRHHLELAAGRRPGTAVTRLYRAGDGSGLGPALQIVNDDMPLLVDSLTAALQRLGATVTEVVHPVFDVLRDRRGRLRAIAPSEGFDVAQANSASRSEGSGNVVTESWIHVQLGAGDSDAVLDRIERALPPLLGEIRQVAHDTEAMTRTMGTLAARLDSVPQPSATEAAECAQLLRWLTSGHFTLLGYGYYRVHPGADGPEPQQVSGTGLGVLRNGSGVDVGAPAPGTEQILRLSNGSLDSLLPGSPDVYVVSVADYAAETTPSVAGEVVGEHVFVGTFTVSGFHENILDIPVISRRVHQVIEWAGLALNSFSGQALLEMLQTFPRVELFSTDARRLFETVSAVMNLGLRRQIRLFLRRDVGSNAVYCLVYLPRDRYSTEVRVRMHEILRREFDAEQIAYSARVTESELAVVYFTVHRGADAEPADITESNRERIQDLLFATTRSWSDRLVSEAAGLAEIAAPVVQDYASAFPATYQQEYEPARALDDLCRLQRLADGQIDTDLYRTAGAPSGEWRFTLYVAGTEVSLSRVLPLLHSLGIEVVEEKPYRLELPGDSTRWIYDFGLRVAPNTLRGTGEGDPEADLDRAVALESLPDNSIRKRLPEAVSAMWFGDGEVDGLNELVLRAGLHWRQIAMLRAYAKYLQQAGFAYTFANITRVLLAQPSTARAFTELFEAYFDPEHLGPVATARAAAISSRLQDEIDAVVSLDTDRILRAILGLITATLRTNYFRRDEDGNPPGHLSFKFDPHAIAELPRPRPQFEIFVYSPRVEGVHLRFGAVARGGLRWSDRLEDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPAATGDATADRQAMQAEGIACYRTFISGLLDLTDNVDHAGGEVIPPQRVVRRDGDDTYLVVAADKGTATFSDIANEVAQHYDFWLGDAFASGGSAGYDHKAMGITAKGAWESVKRHFAEMNVDTQREEFTVVGVGDMSGDVFGNGMLLSEHIRLVAAFDHRHIFIDPDPVAGSSFAERKRLFGLARSSWADYDTSLISEGGGVFDRSAKAIAITPQIRAALDLDPGVSTLSPPEMIRAILLAPVDLLWNGGIGTYIKASTESHADVGDKSNDAVRVDADLLRVKVIGEGGNLGATALGRIEFCKLGGRMNTDALDNSAGVDCSDHEVNIKVLLGAAISSGELAESDRNALLAEMTDEVSALVLRDNISQNFRMGLSRSNAAAMVGVHRRLIAELETRRGVDRQLEALPSDAELDRRAAAGAGLTSPELANLLAHVKLSLKSDLLSGDLLDSSAFEALLPGYFPTPLRERFGAAIGRHPLRREILATMVVNDMVDYGGITYAFRLAEEAGATTDDAVRAFTAAVEIFDLRALWERIRTTPMPAAARNELEMETKRTLDRAARWLLTNRPQPIAVGAGIARYRDGVRALAARVPAWRPGALADDLMSRSGGPIGHGAPRELAEEVFLLIHRFPLLDVLDIADICERDADEVAALYYALDAHFDIQRLLSAVAGLDRGDRWQTLARLAVREDLYDSLRSLTADVLTTTEPVDTPEEKIAYWESTNRSRLSRARAALGEIFTSEAHDLATLSVAARQVRSMVGSAETTATVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD0</accession>
    <name>A0A231GWD0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783776.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40924">
        <property type="protein sequence ID" value="OXR40924"/>
        <property type="gene ID" value="B7C42_07059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="13294" checksum="D59D7A4A3F0C9AB1" modified="2017-10-25" version="1">MTSVRQVQITFDCAEPERVARFWSSVLGYEHRGSACVDPSGVGPRLLFQRVPEGKVVKNRLHLDVRVGTGLVGQERVAALEAECARLVALGAVRVRLLRADGVNESCLVMQDIEGNEFCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWE8</accession>
    <name>A0A231GWE8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA_dh_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40892">
        <property type="protein sequence ID" value="OXR40892"/>
        <property type="gene ID" value="B7C42_07027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="359" mass="38633" checksum="FF5F9069C72C544D" modified="2017-10-25" version="1">MTFAKTGTDHPLVAKVRDYADTVLRPRALATDRDGVDTAHIEELAALGLLNHTAPPRYGGAGVDRETDRQVHEIIAGACFNTWLVWAQHASLSERISTLEATGAPIPPLAQRILRGELLLGAGVSDVRRYPDHYIAARKAEGGWIFDGTVSWVSGWGLNSALTVAAVEKDTETVVTALVPVDDRLHSAGPLALGAVAGSRTARVALRDVFVPEENVLTTESIERARFLDQGVSNDARAQHFGLADTVLRELELTPEQPAQQVAAVWRPRFDQLRTTAYDLSDEARTHGGGAYRAEDRLAVKVAVGEALSAITRALLIARSGRGLAGDDTAQLYARTALFLLVQGQSADVRRAQLAELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF5</accession>
    <name>A0A231GWF5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_6</name>
        <name evidence="2" type="ORF">B7C42_07043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783806.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40908">
        <property type="protein sequence ID" value="OXR40908"/>
        <property type="gene ID" value="B7C42_07043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="37510" checksum="BCB63C80004641A3" modified="2017-10-25" version="1">MSLSDLRTLGRTGVRISPFVLGTMNFGARGNTSHEESVALIHRALDAGINTIDTADTYSRGESEIIVGKALAGRRDQVILASKFHNSVDDDPSHRGNSRRWIVRAVEDSLRRLGTDHLDLYQVHRPESITAIDETVGALDDLVRAGKIRYYGTSVFSPAELVEVQWSADRRRWHRAVSEQVPYSLLVRGIERETLPIARKYGLGVLTYGPLAAGWLSGKYRIGADQPASHRADLIPGRFDIDAPANAAKLAAADALARLAEESGLSLIELAIGFAGSHPDVSGIIIGPRTGEHLDTYLRAADVVLESEVLDRIDEIVPPGTYFHERDTGKIPDALADPALRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWJ3</accession>
    <name>A0A231GWJ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein ZapE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zapE_2</name>
        <name evidence="3" type="ORF">B7C42_06908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40942">
        <property type="protein sequence ID" value="OXR40942"/>
        <property type="gene ID" value="B7C42_06908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="33813" checksum="B2FA4EC2EF6174F8" modified="2017-10-25" version="1">MVPPPTFDEVSFASYIPDPKEPTQAAAVRAAEDFATRVGKIHAAAGKKSLFGKKKQVDGAGLYLDGGFGVGKTHLLASIFHASPGPKSFGTFGEVTNLVGALGFTNAVERLGGNSVLCIDEFELDDPGDTMLVSRLLTELTARGVSVAATSNTLPDQLGEGRFAAQDFLREIRKLGSLFDAVRVDGPDYRHRDLPPAPEPTDPGLLTEKAAATPNSTLDDFDALLAHLSTLHPSKYGSLIAGVSSVYISAVHTITDQAVALRMVVLADRLYDAGTPVTVSGAPLDKIFSEEMLGGGYRKKYLRAISRLLALSRFEVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWK2</accession>
    <name>A0A231GWK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41010">
        <property type="protein sequence ID" value="OXR41010"/>
        <property type="gene ID" value="B7C42_06976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167057" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="54" mass="5676" checksum="20529F5D3A1722F7" modified="2017-10-25" version="1">MWVRGLRVVSVLLGIAALVREGVHAVATTASNTLRRPVATEPATRQHTSPIGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWL1</accession>
    <name>A0A231GWL1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_5</name>
        <name evidence="6" type="ORF">B7C42_07016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40881">
        <property type="protein sequence ID" value="OXR40881"/>
        <property type="gene ID" value="B7C42_07016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="293"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="335"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="559" mass="59716" checksum="06178BEB835A5B7F" modified="2017-10-25" version="1">MTTSLLTAAGTAADPPGEPVAVVANLRVTVGPEDAPTTVVHDVGLDVKRGETVGLVGESGSGKTMTALGIAGLLPRGARLSGGRVLLAGLDPAQVSARRRARAVSDRIGVVFQNPTASLNPRLTISTQLFEALPRTLRRRRECAARAAELLEQVGIADVGKTLAAFPHELSGGLNQRVMIALALARQPALLIADEPTTALDVSVQAQVLDLIDRLKVELGLGVLLVSHDIGVIGDRTDRVHVMSAGRIVESGPTAEVLRTPRHDYTKQLLSATPALLRHRDGTAEAPSGPALLGVREVRREFRVTVPGRVRRARHIALDGVTLEVRAGAAVGIVGESGSGKTTLARQIVGLDRPDSGAIEYGGVALDALDRPAIRQWRRAVQYVFQDPYGALDPRLTVARSIAEPLELNGVDLGGTTVDERVRQLLAEVELPAEYAHRLPHELSGGQLQRVVIARALANDPTVIVADEPVSALDLSVQARILRLLERLRRERGLTLLLISHDLAVVRFLCDEVVVLQHGRIVEAGATGRIYTEPEHPYTRALLAAVPGKSIEPYRGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXK0</accession>
    <name>A0A231GXK0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mrp</name>
        <name evidence="7" type="ORF">B7C42_06490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41347">
        <property type="protein sequence ID" value="OXR41347"/>
        <property type="gene ID" value="B7C42_06490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="370" mass="39127" checksum="0C997C6DA3212F23" modified="2017-10-25" version="1">MRGALAKVDDPEIRKPITELGMVKSVSVRDDSSVHVEIYLTTAACPLRTKLTEMVTKAVADVAGVGAVTVDLDVMSDEQRTELRKQLRGDSADPVIPFAQPGSLTRVYAVASGKGGVGKSSVTVNLAAALAARGLSVGVLDADIYGHSVPRMLGTDQRPTQVERMIMPPVAHDVKVISIAMFTQGNTPVVWRGPMLHRALQQFLADVFWGDLDVLLLDLPPGTGDVAISIAQLIPNAEILVVTTPQPAAAEVAERAGAIALQTRQRIAGVVENMSWLDLPDGSRMELYGSGGGQAVADRLTRAVGAEVPLLGQIPITQELREAGDEGTPIVLSDPENPAAQALRGIADKLAVRRRGLAGMSLGIDTTRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY20</accession>
    <name>A0A231GY20_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41517">
        <property type="protein sequence ID" value="OXR41517"/>
        <property type="gene ID" value="B7C42_06409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="10558" checksum="7DFE24E2EA0DE47F" modified="2017-10-25" version="1">MSELSPVPACLTHRTTLAAAPEPRPQLSAREVEVLLAWILGETKGEVCRKLFIAPGTVNTHLARIREKYRGAGRPAPTKAALLARALQDGYLDLDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYH1</accession>
    <name>A0A231GYH1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41571">
        <property type="protein sequence ID" value="OXR41571"/>
        <property type="gene ID" value="B7C42_06464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="62" mass="6689" checksum="30F48E858013E6B1" modified="2017-10-25" version="1">MIGSTDDRLLGFAASERLVRRFPNSAGLVRVPGGHCAPLEYPEIVTAELRKLIDIRVPTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ09</accession>
    <name>A0A231GZ09_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cold shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspA_3</name>
        <name evidence="4" type="ORF">B7C42_06170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780742.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41828">
        <property type="protein sequence ID" value="OXR41828"/>
        <property type="gene ID" value="B7C42_06170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7251" checksum="CA5C8B0E222C5AF8" modified="2017-10-25" version="1">MSQGSVKWFNGEKGFGFIAQDEGGPDVFVHYSEISGSGFKSLDEGQRVEFEVGQGQKGPQAQNVRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ52</accession>
    <name>A0A231GZ52_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41887">
        <property type="protein sequence ID" value="OXR41887"/>
        <property type="gene ID" value="B7C42_05871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="23371" checksum="C3A2ED5DEF98F8D2" modified="2017-10-25" version="1">MTDTTAVLTDPEPTDTANTTPAEPEGGAERRSTPLSSILRRGRRTGESSIKLKTVAVAALVLVLAAAVAVLGWQLNDKTDQIAAAGAERADTAHAEQVALDYATAAAEMNFQDLAAWRTRLTKGTSPELSNRLTQAAGSMEQIITPLQWVSTAKPVAAKMRSHDNGIYAVDCFVSVMTKNSQAPEGIQSTATYQLSLDSHHNWTITDIGGVGSALGGANAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ71</accession>
    <name>A0A231GZ71_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41821">
        <property type="protein sequence ID" value="OXR41821"/>
        <property type="gene ID" value="B7C42_06163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="205" mass="23104" checksum="E2FC68A776DCF0A4" modified="2017-10-25" version="1">MPTPDRFKRSPLAMAVLGILHLEPMHPYAIQRRIKEWGKDKVVNVGQRAQLYKTIARLQDAGLVTVRATGRDQQYPERTVYEITDTGRAACTAWITDMLAVPRNEFPEFPAALSFLMLLGPDGAREELERRLKALRAGHSELETGIAQAVRFGLPRVTMLEDEYQRAVTEAEIRWLEGVVADLADGTLTWSWESLARFQDQGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZE5</accession>
    <name>A0A231GZE5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate transport protein NrtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nrtA</name>
        <name evidence="2" type="ORF">B7C42_05962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CmpA/NrtA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41978">
        <property type="protein sequence ID" value="OXR41978"/>
        <property type="gene ID" value="B7C42_05962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="40492" checksum="D2E6FF234C7C11DE" modified="2017-10-25" version="1">MRPPSISRRGLLCGCAGLVAAGGLAGLADLGVAAADRRGIGGDRLRIGYLPITDAAPLLIAERGPEFAQPVLFRSWSALAEAFLTRQVDIVHLLMPMAIQLRFGLGAPARILGWNHTNGSALTVAPGITEPGELAGTQVAIPFWWSIHNIVIQQWLRANGLRPVIRSSASRSAGTVELIVMSPSDMIPALANGSISAFTVADPFNAGAELRGVGHIHRFLGDLWRDHACCALVVHQDLLDSRPAVAQAVVDAVVAAQLRIGADRPAAAKQLAGRYLPQPLPAITKALTYSDRIPVRHPGWHPQRIGFQPFPFPSFTAALATAMHDTVVDGDTRFLSRLDPASAHGELVDDRFVRSALDRAGGPAAFGLPPGLTRIEEIDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZK5</accession>
    <name>A0A231GZK5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782299.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42056">
        <property type="protein sequence ID" value="OXR42056"/>
        <property type="gene ID" value="B7C42_06040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="33530" checksum="50ECA56B751B4AA3" modified="2017-10-25" version="1">MMAEPVRIGRVDSLVAERGPTALRIAVGGQLRKLREGAGITREAAGEHIRGSHAKISRLELGRTGFKERDVRDLLTLYGVENAEEREMFLDLVSRANQPGWWHSYNDLLPQWFETYLGLEHASKSIRTFEGQLVPGLLQTEEYTRSVVALGHENAEAARRVELRKKRQEILDRPGAPTLWAVLDEAVLHRPIGGEQVLRAQLDHLVAVSMKPNVTIQVLPYAAGGHAAAGSSFTMLRFAEPELPDIVYLEQLTSALYLDRQQDLELYRQVMDRLSVQAEPPERSREMMKKAAADLPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZV3</accession>
    <name>A0A231GZV3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative flavin-containing monoamine oxidase AofH</fullName>
            <ecNumber evidence="4">1.4.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aofH</name>
        <name evidence="4" type="ORF">B7C42_05737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42138">
        <property type="protein sequence ID" value="OXR42138"/>
        <property type="gene ID" value="B7C42_05737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="452" mass="48501" checksum="F9FA18A4B9727093" modified="2017-10-25" version="1">MTDVDCCVVGGGFAGLTAALRLKQAGRSVAVLEARDRLGGRTFTEVRPDGCWIDRGGAWIGPGQDRIRALMGEFGIGSYRQYTDGEAMMVVDGEQYRYTGTIPWTMSPWASINLGAGFAELAYLCRSIPLEAPWDARKAEKWDRITLAQWLTRIRSKTAHDLLETAVAGSYTSAASEVSMLFALYQMASGGGPNFMFSVRGGAQDSRPVGGMGAIYGAMADQVGDSTHLSQPVHGIEQDEAGVTVHAGASTLRAHRAIVAVPLAVAGQIRYEPMLPVDRSFLHQRVPSGSIIKTSVVYDEPFWRYDGLSGQSAAPGSPATVTIDACTDTARPGVLCVITEGPTARRVGRLDATERRTAIVRELVTRFGNRAGSPVDYVEQDWSAERYSGGGMLSHLPTGVLTQFGRALREPCGRIHWAGTESSAVMCGWVDGAVRSGERAASEVLRHELAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZW3</accession>
    <name>A0A231GZW3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782824.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42082">
        <property type="protein sequence ID" value="OXR42082"/>
        <property type="gene ID" value="B7C42_05681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011223125" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="37787" checksum="CC8B470495534A3D" modified="2017-10-25" version="1">MTTTRAGVTAAVCIAALLLSGCTALRTPGRAENHITADFRDTAGIFDGNPVTVLGLQIGTVDKIIPHGEYNEVHMSIDASVQIPEHVVAALVSPSIVTNRHIELTPRYTGGPTLPADAHLTVQQTRTPVELDTMIKTIDQFAAALEPEPGADTGPLSGQLLYSMVNGQGQKIHDTLAALSGALKVGVGNGDAIAGIINKLNELTTMLADNDHSEREFSDKMTQLSNLLAEQAPGLQATLDQLNGMLANTSGTLSQYQDQLAGTLSNLTSVTAQLRANAAGVTETVDLAPLLLQNLDRSMNRSQGFMRGHVVLGTALTGEVVSLFCERIQMRSDGCRTGRLEDFGPDLGLTSALLGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H062</accession>
    <name>A0A231H062_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aliphatic sulfonates transport permease protein SsuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssuC_3</name>
        <name evidence="6" type="ORF">B7C42_05844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779730.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42245">
        <property type="protein sequence ID" value="OXR42245"/>
        <property type="gene ID" value="B7C42_05844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="29726" checksum="DDCCEB392008C6CB" modified="2017-10-25" version="1">MTAVIAPAASTGRLAPPRSRVEKRRPAWLSVPLRFLLPVLIFAGWWIGSATGALSPQVLAGPPKVWSAFTELVHNGQLVDFALASFVRAGLGVGLGVSAGLLLGLAAGLSSLGEELVDSTMQIVRAVPFLALVPLFIAWFGIDELYKVLLIAVATVAPMYAYTYLGVRNVDRKVVEAARGFGLAGPRLVLEVILPSALPGILMALRVCLSISITGLIAAEQVGTSKGVGYLVTLAQEYNRTDYMVLCVVLYAVLGLVFDGAVRLIERFAMPWRGQVAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0J9</accession>
    <name>A0A231H0J9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_05556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42357">
        <property type="protein sequence ID" value="OXR42357"/>
        <property type="gene ID" value="B7C42_05556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="458" mass="48443" checksum="74632EF4D7B25323" modified="2017-10-25" version="1">MNGAMTTLPEQPGDRSAEAPLLLTTAPPRTLSFGDQAAFWANLGVSLIGFTGAFYVLQPAGHPQLPVAAAVLATAVGTVLGTAMVAAAGAVGARTGAPAMANFRGLFGTRLSYVPTVANIVQCIGWGVFELTVIAGGVAALTHGHLPHGAVIVGAGVLCTAMAIWPLNVLRILRKYVTVAVAVAMGWFTIQFLRQPLPPVTGTSWSGFFPGVDTALAVAVSFVPLAADYTRHARGARAATGATMVGYSIAQTWCYLLGIVALLQAGGDPDRIFDTFLGVAAGWLFFAVLVLRESDQSFANVYSTAMSLQNLLPRVDRRILAAAVGALATVLAMGVRDFTGFSNFLLLIGSVFVPLCAVLVVDYFLGRGRRGWDLSETAPARPLLLLPWFLGFVVYQVLNPGSVDWWARIWLWVQDVVGVHPGWWSSASLYSFLAAAACTGVLARLERVPDRAEPERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0K7</accession>
    <name>A0A231H0K7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_23</name>
        <name evidence="9" type="ORF">B7C42_05566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42367">
        <property type="protein sequence ID" value="OXR42367"/>
        <property type="gene ID" value="B7C42_05566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="136"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="253"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="43970" checksum="0E2103AE74CD6F65" modified="2017-10-25" version="1">MYKWSDEDLMLRDAVRGFIKKEIEPHVDRLESGALPPFDIIRKLYATFGLDEMAREGLAKSLAREEAGTPGKSGGFSGAGSMGVILNSELAGVSLGLVASMGVSLGLAVGTIRSRGTLAQKKRWLPELVTFEKVGAWAITEPDSGSDAFGGMKSYVRRDGEDYILNGRKTFITNGPYADVTVVYAKLDEEDGTDRRDRKVLTFVLDKGMPGFVQSAPFKKMGMNSSPTGELVFDNVRLTPDRLLGETENPAKGDGKDSAQESFAAERIGIASLALGIINECHRLCVDYAKSRTLWGKEIGHFQLIQLKLAEMEIARINVQNMVFNAIERTAAGESVSLAEASAMKLYSSRAATEVAMEAVQLFGGNGYMAEYKVEQLARDAKSLMIYAGSNEIQVTHIAKGLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Q2</accession>
    <name>A0A231H0Q2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064911059.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42454">
        <property type="protein sequence ID" value="OXR42454"/>
        <property type="gene ID" value="B7C42_05656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="28344" checksum="3739E34D229EAED8" modified="2017-10-25" version="1">MTTHAYIEPIAQLRAARDRAADARNLSRALELDNELEDLGQLGNSPRRTCWRCDSWADHVHEPHTGARMAVHGPVPADEAYTAVAVQVFALAATALPHHWSENDGVATVVVDMGAHRFAVTVHPGDGDGSHGYRRDVYISHCVHRPTGQARPFPALHAPWQRTAAIIEAYRYARNVGIAPAPAALAGPVRADDPDDLLRRLRLRHSEIDAEIDGHAADSDDGHRERLAALYRDAVALATVLDGHLSGGGRLPLDWAHATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0T7</accession>
    <name>A0A231H0T7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome P450 135A1</fullName>
            <ecNumber evidence="2">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42480">
        <property type="protein sequence ID" value="OXR42480"/>
        <property type="gene ID" value="B7C42_05256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="437" mass="48593" checksum="3FB5CFF9BAF2AE2F" modified="2017-10-25" version="1">MSTVFPPGPRLPRVAQTLLHAKWRGWFAGVASRRYGDVYTMRMIAPYAENLVVFSRPEHIREIFAGAPADLHAGEGNRVLEPVMGQHSLLLTDEDEHARARRLLMPAFTGSALRGYRDLVEAIAKHHIDQWQPDTTLVTLPRMNDLTLDVIMQVVFGISEQRGRADLAPRLRYLVDVGPLIFLGWKWHRLQRFGPWKRFADNKDAIDALLYEEIARRRGEPDPGDRADVLARLLAVGAQAGDEPLSDAELRDQLVTLLLAGHETTASALSWAMFELAAHPDVQQRARRAAAEGDDRYLEAVLKEAMRRHPVIGGTLRRLTRETTIGGYTLPRGTVVQTSIVLAHANPDNHPEPESFRPERFLDGSVAANTWLPFGGGVRRCIGAGFSLMEGTAVLSEVLGRFALAPVRTRERGRIRNITNVPAHGAPVLLRPHPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0T8</accession>
    <name>A0A231H0T8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064911053.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42446">
        <property type="protein sequence ID" value="OXR42446"/>
        <property type="gene ID" value="B7C42_05648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="32800" checksum="58A16A2B03C65B69" modified="2017-10-25" version="1">MPNARIPAHREATPLALIRQRFAGLTDYRVPGLPPGWDRLNANRLATLLNSQVPAEEVDAVWVRLIEAARTRDETAVLVCAGAALPMLSAITAKLCGHWAYRADTEAMVLVAFLDAVACLDVARPNVAYRLRWATFHRACPPVRERMAAPTPIDWLPDSGHSRDGKAVSSPQGHPELLLALAVEEGVLTAADAGLIIDTRLHPRRLKTIAAETGINYDGLAKRRRRAEHRLAAWLRERIADTQVSTRVETAALDTLTHTATRRPAPARMSKTGSAARVLPLPKSAPTAAHPSHEEQRRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0W6</accession>
    <name>A0A231H0W6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit M</fullName>
            <ecNumber evidence="6">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoM</name>
        <name evidence="6" type="ORF">B7C42_05265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42489">
        <property type="protein sequence ID" value="OXR42489"/>
        <property type="gene ID" value="B7C42_05265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="137"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="549" mass="57687" checksum="FA39E392D98CC301" modified="2017-10-25" version="1">MTEYPWLTTLWVLPLAGAVVVLAVPAGRRTLARATGLVLSLATLAVAIVVAVRFDPGGPQYQLVESHRWIPAFGAGYTLGVDGIALVLLLLTAALVPLLILAGWKDDREAGSGRRVAHIYVALTLIVEAMVLISFVSLDILLFYVFFEVMLIPMYFLIGGFGPRTSGGESAAVELALRQQRSRAAVKFLLYNLFGGLIMLAAVIGLYVLTARAHLGGEGGTFDFRAVTAAANSGQLGAGPAVLNALFLGFMFAFAVKAPLWPLHTWLPGAAVSATPASAVLMMAVVDKVGTFGMLRYCLLLFPAASTTYAPMISVLAVIGILYGALLAIGQTDVMRLIAYTSISHFGFIILGIFAMTDQGGAGATLYMVNHGISTAALFLIAGFLVSRRGTRAIAEFGGVQKVAPILAGTFLIAGLATLSLPGLAPFVSEFLVLVGTFTRYPVAAVFATGALVLAALYVLWMYQRMMTGPVRKGNERLPDLLPRELVVVVPLLAALLALGAYPKPVLDRINPAVAGTLTTIGKHDPAPMVAPDAATVPAATTPSGGNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H159</accession>
    <name>A0A231H159_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fluoroacetyl-CoA thioesterase</fullName>
            <ecNumber evidence="4">3.1.2.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flK</name>
        <name evidence="4" type="ORF">B7C42_05313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.29" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42537">
        <property type="protein sequence ID" value="OXR42537"/>
        <property type="gene ID" value="B7C42_05313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="PTHR36934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014972">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13240" checksum="51B5A3C796021C1B" modified="2017-10-25" version="1">MKVQPGLSAEFRVEVGATDTAVAVGSGDVAVLATPRVVALAEHATVLALRGRLSSAQTSVGIEVSVRHRRPSPPGTVLTVAARLAEVDGPRLAFRVVVHDGDLPVADGTIRRTIVDRASFLARAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1E0</accession>
    <name>A0A231H1E0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator MtrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mtrR_3</name>
        <name evidence="6" type="ORF">B7C42_05446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42668">
        <property type="protein sequence ID" value="OXR42668"/>
        <property type="gene ID" value="B7C42_05446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="21353" checksum="8A129D4D84E15438" modified="2017-10-25" version="1">MVAGKDGQVSTPATPRRTRADAARNRDRLLRAAREVFAEKGSQAQLPDVARAAGVGVGTVYRHFPTLAELVDAAAEQRFAEIENYARAECLAHAGEGLRRYLTHVGELLSADQGLSAAVEAARRSPGSEPRGSARARLETVVGEIITRDREAGALRQDCTAADAYMLVGAISATIRTGSGDWRRLLDLMLDGLRPRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1G1</accession>
    <name>A0A231H1G1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42676">
        <property type="protein sequence ID" value="OXR42676"/>
        <property type="gene ID" value="B7C42_05454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="31463" checksum="5360AC88B55FF4B7" modified="2017-10-25" version="1">MAATNNFVEYRSVAITEPLRQGDILERVADDSTVWNRHLLVMTADCDFAHNKHHGRVTCVPLLTKDEYLVKLQIPKLRSKAVIDLTKSLQDALIRLGTTSISEARLREWPSEQPTEKILASLPIPDDEHDAVRGMFDAIRALDSSEPSLAEATSILVQAQLQLPNPQSEKNLRRKIVNTLQNAFKNPPGDALFLSAIADGHDYGYFVYLRHLEQIWEPRVALSPSRTVMEYRRLSRLQDNFTHAIAQRFGLVFTAIGLPDAYEEMRNLHSDLLGEDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1N3</accession>
    <name>A0A231H1N3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42727">
        <property type="protein sequence ID" value="OXR42727"/>
        <property type="gene ID" value="B7C42_05064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="348" mass="37797" checksum="9B827EB0F78216FD" modified="2017-10-25" version="1">MQRLNRFGSGLFRPRDRRVADAATTRRREIRLGIVGVALVVVCAAAAGILYVVPFGKKTYSAELSEAQSVKVGDDIRVAGIPVGKVESLELHPDRVRMRFTVDSDVFVGDRSTLDIRMLTIVGGNYVALFPAGDKPLGDKAIPTDRVRLPYSLVQTFQDAAQPLRQIDGDTLRRNLAALDTSIESAPDALRTTLNTLGTYVDALNRQRTQVTDAIAVADEYVTMYDGAKHDLGRLMVNVNQMETLLVDKRAELREGVRLLRAVIERVAALAPTYDSALKPKLQQLGDALPQLEKLGGELEPVIGTVQSLQQKFSQLAGTDGPVTVDQSGQTVSAPADHLCIPVPGKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1U8</accession>
    <name>A0A231H1U8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036504456.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42819">
        <property type="protein sequence ID" value="OXR42819"/>
        <property type="gene ID" value="B7C42_05157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="232" mass="25326" checksum="1C394FC9F4DE8C92" modified="2017-10-25" version="1">MGANTSGALGVSTESDHRIPADHLGVTDLFAVLAYGEISAFYRLAEEAKLSPTLRGKVAVAKMAAAEMEHFATLERALQGRGVDVFDAMAPFVRALDDYHASTDPSNWLESMVKFYVGDGIAADFYAVLADALAPEVAAVVRDVLAETHHSEFVIEEVRRAVTVSRSERDRLTLWGRRLLGEAITQAQYVMAQRDELTELVLTATGDLNGVAALFERMQNSHAERMRVLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Y1</accession>
    <name>A0A231H1Y1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase</fullName>
            <ecNumber evidence="2">1.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42853">
        <property type="protein sequence ID" value="OXR42853"/>
        <property type="gene ID" value="B7C42_05191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="34142" checksum="2EE61B18E49EDD58" modified="2017-10-25" version="1">MNGSVGPAPSFGIKTTPAHIGYADILRVWLEADDIPEIEHAWLYDHLLPRAAVGLPGHDGGDSTGSRSAGPVLEGWTLLAALAAQTRRLRLGLLVSNNRIRHPALLAKMAATVDVISGGRLDFGIGVGGFPRNDPRFATMVAPEYAAYGIPVGTWRDAVSSLGEACVLIRRMWTEEVFDFPGEHFPLTGAQCDPKPVQRPHPPILLAGAGASTLPIVAAHADLWNVIGPPLTGVDTLREHSRALDDHCAAIGRDPAHITRSAQLPISYDDPGRIRETLLELIDAGFIHLVLNPPAPYPDGVAHWIADEIIRPTLDAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2F5</accession>
    <name>A0A231H2F5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RecBCD enzyme subunit RecC</fullName>
            <ecNumber evidence="6">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exonuclease V subunit RecC</fullName>
            <shortName evidence="6">ExoV subunit RecC</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Helicase/nuclease RecBCD subunit RecC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recC</name>
        <name evidence="9" type="ORF">B7C42_04915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RecC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43029">
        <property type="protein sequence ID" value="OXR43029"/>
        <property type="gene ID" value="B7C42_04915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009338">
        <property type="term" value="C:exodeoxyribonuclease V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01486">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006697">
        <property type="entry name" value="RecC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041500">
        <property type="entry name" value="RecC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17946">
        <property type="entry name" value="RecC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000980">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01450">
        <property type="entry name" value="recC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecC_C" evidence="8">
        <location>
            <begin position="844"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1156" mass="123705" checksum="5CF6A250F2461D07" modified="2017-10-25" version="1">MLHIHRAESARTLADALAAMLSNPLPDPFAAEVVAVGAHGVQRWLNQRLAVTLGARAGDGVAANIDYPTPAALVADISAAASDIAADADPWAPDRLVWPVLAAMDAAIGEPWAAVLARHLGVGAGPAEAYRAGRRLSTATHIATLFDTYGTTRPTLITDWADGADTDGCGADLPDDLRWQPRLWRRVREAIGIPAPAQRLDAVCRRLRTDPASIDLPQRLSVFGLPRIAAAQLAVLEAVAEHRDVHLWLAHPSPALWERLRSDTDAAVEGVRPTAGGVAGSGETAEAAAGPAAAATSVRTRPAAPRRVVADPIARHPLLAALGRDVREVQNRLATVDFADRHHQPGSGVDRLGAENDSGTVLSEVQAAIRADRWPPVGCAADDSVQIHACHGPARQVEVLRDVLLGLFQRDPTLEPRDVIVLCPDPDGYAPLVRAAFGQGPAALDDPGVNPAHGLRVRPAERSAGAANSVLAVLEDLLALAEGRVGVTQVLDLAATEPVRYRCGFDDDDIERLREWAAETGARWGIGQRQRQAFGLAEFGQNTLNAAVDRILLGVAAGESGEDWLDLALPLDDVDSGDVDLAGRFAEFVDRLAVCVRDLSGPTPAEPAGAPRPARQWLQILHRALDLLTDLPAAAAWQGVQARRELAAAFEHADAAELRLPDVIAALRARSRARAPRSNYRTGELTVCGLAPMRSVPHRVVVLLGLDDEVFPRTGGIDGDDVTARKPLVGERDPRSEDRGLLLDAVLAAEQHLVVLYTGADPVTGTPRPPVTPLAELIDVVCAHRGTGEVVRRHPLQAYDGRNFDALDPFGFDTLALAAARAAARPAQPSPPWLPGPLPAVARTDVELAELVSFAEHPIRAFLWQRLGIRVPEEDEDIDERLPIELTGLATWNIGERMLAARLTGADPGALRAAEWRRGTLPPFGLGASVLAEVESTVDRLVQVAAPLQQAPARTIDIAVDLGSGRRLTGTVADVHDDAVVRATYSRLAPKHRMAAWVRLLALAATERHQSWQAVSIGRGKFGRPAWRSSLTAPAPALAADLLRELADLREEGLAEPLSFAPSASAVYAERRCRGADLDSARAAAEEEFYGGPKGPRPFGDHTDRYLTYIRGPEPTFEQLETPLPEPDRYGETTTFGSVARRLWNPLLANESQGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2G1</accession>
    <name>A0A231H2G1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloacrylate reductase</fullName>
            <ecNumber evidence="2">1.3.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.103" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43040">
        <property type="protein sequence ID" value="OXR43040"/>
        <property type="gene ID" value="B7C42_04926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102523">
        <property type="term" value="F:2-chloroacrylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="32662" checksum="056C90FBC5964E8E" modified="2017-10-25" version="1">MKAIRLHEFGPAENLRYETVADPLPEAGQVRIAVAAAGIHLVDTRLRRGLPGPYPLPQLPTIPGREVAGVVDLVGSGADPDLLGARVVTHLGAAPGGCAALAVADAQRLQRIPDALEAAAAVAMIGTGRTTLGILGFAEVEPGQLAVVPAAAGGIGTLLVQYLRGAGVTVVGLAGSAAKVAAVAANGADLALDYTDPGWPDAVRARFGDRPAHWVFDGVGGAAGRAAVELLAPGGAHLVFGWSDAAVEFAPDELAARGITSRSVLGPEMLERGGGIAALETRALAAAGSGRLRPAVHRFALADAAAAHRALEDRATVGKVVLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2J1</accession>
    <name>A0A231H2J1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43070">
        <property type="protein sequence ID" value="OXR43070"/>
        <property type="gene ID" value="B7C42_04956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="13175" checksum="524649B0D5755778" modified="2017-10-25" version="1">MAAAAPNPADTPRQAVARAYIDALVSHDASAVPFAPDATRVEAGLKTGYSGPQLIQELNHGIQYSVIQDIRDLRMTECGDVVTARYLLDSGVAGVRLMTVDITETFVIPDGTIHTINATIDPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2L4</accession>
    <name>A0A231H2L4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517724.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43086">
        <property type="protein sequence ID" value="OXR43086"/>
        <property type="gene ID" value="B7C42_04972"/>
    </dbReference>
    <dbReference type="GeneID" id="66719420"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="17711" checksum="C1FC113706F58C76" modified="2017-10-25" version="1">MSEMRVIGIRVEQPQNQPVLLLREESGDRYLPIWIGQAEATAIVLEQEGVTPIRPLTHDLIKILIHDLGHTLKEVRIVDLQEGTFYADLVFDNDVRISARPSDSIAIALRVGCPIYAEEPVLEEAGLVMPDEREDEVEKFKEFLESVSPDDFKATDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2R4</accession>
    <name>A0A231H2R4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43141">
        <property type="protein sequence ID" value="OXR43141"/>
        <property type="gene ID" value="B7C42_04563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011721">
        <property type="entry name" value="CHP02096"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02096">
        <property type="entry name" value="TIGR02096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18390" checksum="BBE38538246A9EA6" modified="2017-10-25" version="1">MSTHEDHAQRWAKALTTDTAAAVELYADDLVYDDHADRDHVLSTAITKQELEPRLAPFANTDPANGVGIHRFDVFETFPLAGVGGNPAVVIRWQWTGEGLETYRGVPTGGKTLTTQGITWHQLDADGKIARETTYWNDTPVLQELGVPIITPEYWVEGFDPSTLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H301</accession>
    <name>A0A231H301_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43235">
        <property type="protein sequence ID" value="OXR43235"/>
        <property type="gene ID" value="B7C42_04657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="39662" checksum="F9F2F1F1B12BAFEA" modified="2017-10-25" version="1">MSAPSVAIAGLGMTEMSVRPGGTPLQLAVEATGAAIADAGIEHRDVDGVLVGSSQGVRPDRLGVGFAAQAGFADLRLLEHVEIKGATTIAMVQRAQLAIETGAATTVLCVFADAPLVAGKGAGSTYAHSGGNAGPRGLERASGVLGSVPTYALLARRWLHTTHSSEADLCRVVTTARGWALGNPAAVVRTPLEEQGYYDSPMVSDPLRRLDCARPVNGAVAVIVSADPAVGADGRLIVRGIGRHHPIRRRRAGRESWFGGGRRAVDDALEQSGMSRGDLDIAELYDPFSVVTLILLDEYRLTGAQPVSEFVRAGGIGPGGALPTNTGGGQLSGFYLQGMTPLAEAIVQLRGAGGERQVPDAVTALVGGIGGRVDHHAALILERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H323</accession>
    <name>A0A231H323_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-succinylbenzoate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menE_2</name>
        <name evidence="3" type="ORF">B7C42_04649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.26" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43227">
        <property type="protein sequence ID" value="OXR43227"/>
        <property type="gene ID" value="B7C42_04649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="416"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="514" mass="54406" checksum="9D22A8F4A951C89A" modified="2017-10-25" version="1">MTAAEILAPLDAGAFADTVELLEAAALVHGFRDAYVEADGTRISFADWVARARAVARQLSSHGVGRGDVVALMLPSGIDYAVCYAATAMLGAVTTGLNPRLGPREIDAALRQADPVLVVRAATMPATGRDLPELAASELTRELLRHAATPSRTIGRDAPVSIVFSSGTTGLPKGAWFDANNLAASAQAAGAMSAPYDRRLTSTPFAHVGYMSKLWDQLVWGITLVIAPVPWSAAAMFDVLRAERITVAGAVPTQWAKLLELPALTPQSLPHLRIGVVATAPASPALVRQTTERIGAPLVVRYAMTESPTICGTEPGDPPEVLYRTVGRPQTGVEVAITDAGGVTLPAGQIGRVRIKSGCSMRGYWNDPELTAAAFDEQGYLISGDLGRFDAVGNLVLAGRSGDMYIRGGFNVHPVEVEQVLAEHPRVRAAAVVGLAAEVIGEIGVAFIVPEDPDAPISLAELRDWAKARLADYKAPDHLIVVGDLPRTAMSKLDRHRLRQLAADNPPPPRRKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3I9</accession>
    <name>A0A231H3I9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43417">
        <property type="protein sequence ID" value="OXR43417"/>
        <property type="gene ID" value="B7C42_04284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17827" checksum="E78988EAA661B514" modified="2017-10-25" version="1">MGVPGSVEQVFAVLSDGWSYGHWVVGSTHMRDVDQDWPRIGSRIHHSVGAWPLMAQQATRVVAVDPPNSIELEAELWPLGVAWIRLAMTPIDADTTEVSMSEEVIRGPGRFIPDIVQTMALKPRNKQSLTRLCDLVASHYVDTRKPDTRRPGALAPDNPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H403</accession>
    <name>A0A231H403_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43492">
        <property type="protein sequence ID" value="OXR43492"/>
        <property type="gene ID" value="B7C42_04359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="16336" checksum="F2E40986FD7F9A7B" modified="2017-10-25" version="1">MNATRYIAPTGIDPIMNRIFNVLPKWGISVMGSRLLAVRGRTSGEWRTTMVNLLQDADGTRYLVAPRGRTQWVRNIRVAGGGELRLGRKTEAFTVTEVADADKVPVLRLYLKKWGWEVGKFFEGVTADATDAELAAIAPGFPVFRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H482</accession>
    <name>A0A231H482_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43516">
        <property type="protein sequence ID" value="OXR43516"/>
        <property type="gene ID" value="B7C42_04384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="556" mass="53473" checksum="DBA589E9C4997FEC" modified="2017-10-25" version="1">MHTIGSGTDSGVIAAPAAPAADTSPIAPAAPASIPDAELASAVQQGPITDIPLPQLPPDTPPASAPAFTTARKEFEDNGSHGIGAPHLPGGGAGPDAGDGHAGVLGDAASPLLGAGHDVLHQAAGALGGVPGAQHVLDGAQAALNQAPAALDGAAGAVQQAAAPVAAAVPANLPPMPADPVAALMSGMALPALPGIDVLFKPFLDLLSSFGTGVMGALNPADLLSQSSQVIQSAMQIGMGAMKSVEQVWQGQSASSAQTAGQQVQAHGEDASQRGFDISKLTDEAAAVVQRGNVQLTQVAQSFATQAGALAPVAFTPPGQATLIAAATEHLGQAVAIVNATRGELGGYTGQLANVVNQLAGQYAPQAADAAQAVAQNVGQPIVEQAQSLLSGGGADTQAAGLGDPSGSGLSGASTHASAFGGNGAHPGSMSGSGGGALSGLTGGLGGTASGGGAAAKPGLGSAVPGARPGIPGMPFGPGMPGTPGQGTPGSGFMGGGTPGAAGQRNADDDRGRTVQNYQSLTGNTDLTGPLGETTPEVIGQTHSDELISDYENDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4C5</accession>
    <name>A0A231H4C5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43715">
        <property type="protein sequence ID" value="OXR43715"/>
        <property type="gene ID" value="B7C42_03950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012330566" evidence="2">
        <location>
            <begin position="32"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="39815" checksum="002B451EE023BAEA" modified="2017-10-25" version="1">MRKLWAAVAGVACSLALAATATVIEAPGAAADTPAVQSVEPLSAAATLPGSVDSQRILYTTSTVGNQPTVASAAVYFPPGPAPAGGWPVVAWAHGTVGLGDSCAYSIAGPGDVERDWAYLGTWLKQGYAIVAADYAGLGTPGDHPYLNGVVEAHNVVDAVRAAVDHYSRLSHKWVVVGQSQGGGAAMFTARYATEFGGPELDYRGAVGTGVPAYIEDILMPLGPGIPPVKLSPHTTGYVLYILNGLRTTFPELGIESFLNDSGRSWLDRAKDECLLPLGDDLAAAGVVIGDLFTRPLAQVPDLHGLLAGYLGLPETGYDRPLFMGQGLRDTDVITPETLRYAGVLTANRQPLTFRVYPTDHSGTVNASLVDSLPFVRGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4D5</accession>
    <name>A0A231H4D5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phthiocerol/phthiodiolone dimycocerosyl transferase</fullName>
            <ecNumber evidence="5">2.3.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acyltransferase PapA5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phthiocerol/phthiodiolone O-acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Polyketide synthase-associated protein A5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B7C42_03960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol = a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase].</text>
            <dbReference type="EC" id="2.3.1.282"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol = a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase].</text>
            <dbReference type="EC" id="2.3.1.282"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone = a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase].</text>
            <dbReference type="EC" id="2.3.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyltransferase PapA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.282" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43725">
        <property type="protein sequence ID" value="OXR43725"/>
        <property type="gene ID" value="B7C42_03960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031641">
        <property type="entry name" value="PapA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16911">
        <property type="entry name" value="PapA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PapA_C" evidence="10">
        <location>
            <begin position="305"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="440" mass="47968" checksum="9F814AE01BAAF198" modified="2017-10-25" version="1">MVLRMVTQRPISPFESGYFQEHATFGSVPVGGMALFIGSTVEGEFDTELLRTVLAELAAENPLLSCRRVDDGGMLVLRHVEGYRPPVTESPGGDIEYVDFVNQPQPWDDGLFFARVFREDDRTRIVLVIHHGITDGRSAFALLDEMWRRYTAHHHGAPMPVRANHELPQAVDERLTAVVSEAEVTELLAAMRTIIGEPPARLPRDGTAGSGRGLFVAERIELEPEVTAAFAASARAAGIGVNALLSGCALAAVRAELGGVGALPMVCGYAADMRSALDPWLPDETVLNCASGWGTLLAVAESADPFDLGRVVHADVRAALERRDPARVALAGRYIRDEATARMLAEQPSIALSNIGRVPDHIVPEGVRLVRDNLLAMGPGMPPKLTAFTLGERLTVQVEYDTNDHSRAQMGRVRRNLAELLHRTAADVGVAPKFTWWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4K5</accession>
    <name>A0A231H4K5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43873">
        <property type="protein sequence ID" value="OXR43873"/>
        <property type="gene ID" value="B7C42_04112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="131"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="43617" checksum="1134243AB3B2AF12" modified="2017-10-25" version="1">MTPFAFRRTARGLGAVAVVGVTAMLVGSCSSNGIYSVPLPGGADVGDHPMRIDVRFDDVLDLVPQSAVKVEGVPVGRVESIDVAPDGWTASVHTVVNSSVKLPANAHAEVRQSNLLGEKFVELSAPKDEASPDRLKDGAVIPVDRTRHAVEIEQVLGALSLLLNGGGVAQLQPIVVELNKALAGRENRVRSLLDQADTLIDGLNQQVADIQHALDSLGTLSSRVGQQSDQIGKILDELPAGIKILDQQRPQLIGLLKQLDRVGQAGVDVLDKSKDNLIRDLQALRPTLQELGRSAPDLVTAFPLVLTYPFPDEAIKSTFGGSVNTWLSVDTQIGVLMSNLGVGKPDPVYIPPRYGPPVPVDPTNPYYNGNGPRPGWPTVSLVPLPPTVVAPAPAKPGDPIGSILDQLGVKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Z2</accession>
    <name>A0A231H4Z2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tycC_1</name>
        <name evidence="11" type="ORF">B7C42_04173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43934">
        <property type="protein sequence ID" value="OXR43934"/>
        <property type="gene ID" value="B7C42_04173"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="991"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2054"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3110"/>
            <end position="3185"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="4180"/>
            <end position="4256"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="5234"/>
            <end position="5314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3409"/>
            <end position="3429"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1026"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2089"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="3145"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="4216"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="5274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="5885" mass="632051" checksum="BF419AA7AEE5D2AF" modified="2017-10-25" version="1">[encoded data, 5885 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5K4</accession>
    <name>A0A231H5K4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500238.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44100">
        <property type="protein sequence ID" value="OXR44100"/>
        <property type="gene ID" value="B7C42_03656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="16186" checksum="E7734F3CC8FA8924" modified="2017-10-25" version="1">MADRTQRSITIDAPSDRVMAVIADLQSYPEWVSAARSVDVLETFPDGRARTAKFVLDAGVVKDTYVLSYTWRADGRAVSWKLVSGELQKAQDGTYELIDQPDGTTQVVYELTVDLTIPMIGMFKRKAEKVITDTALKELKKRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5S3</accession>
    <name>A0A231H5S3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytoene desaturase (Lycopene-forming)</fullName>
            <ecNumber evidence="6">1.3.99.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crtI_2</name>
        <name evidence="6" type="ORF">B7C42_03669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 4">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.31" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44112">
        <property type="protein sequence ID" value="OXR44112"/>
        <property type="gene ID" value="B7C42_03669"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="5">
        <location>
            <begin position="439"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="525" mass="56055" checksum="820AA5DC81D9517E" modified="2017-10-25" version="1">MKTVPGQCDRIVVVGAGLSGLAAALYLTGAGRRVTLLERADHPGGRVGVYRGPDYEIDSGATVLTLPGLIDEALAAVGTDAAAHGLRIHRLDPAYQARFADDSVIGVYADPERMAAEVRRTCGAEQAQRYLDLRGWLARIYAGAYDQFMDTNFDSPLDMVRIPEKRAALWELVRLGAFGRLGPRVQRILDDPKLARLFTFQALYAGTAPAQALAVYGAIPHMDTSLGVYFPVGGMRAIAATLAAAFTGAGGQLELNCEVSGIDYHAGRARRVRTADGRGFECDAVVLTADLGSSSRFGIRRRRPLRAAPSAVVAHGTIPAEVAARWPLQAHHTIDFGRAWDETFADIAARRGRGRLMSDPSLLITRPALSDPGQFVERATGRYEPLSVLAPCPNLDAAPLDWPRLGPAYLGELLAVLEQRGYRGIAEHFTVDHLDTPQTWFEQGMIAGTPFSAAHLFRQTGPFRTRNLARTPANVVLAGCGTTPGVGVPTALLSGKLAAERITGAFRHAGGATAPTGALGLPANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H672</accession>
    <name>A0A231H672_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter ATP-binding/permease protein</fullName>
            <ecNumber evidence="13">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B7C42_03168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44379">
        <property type="protein sequence ID" value="OXR44379"/>
        <property type="gene ID" value="B7C42_03168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="245"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="278"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR44379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="804" mass="86697" checksum="535F1E1CBC02F9E6" modified="2017-10-25" version="1">MQTRERVYRLHAGGSYNVGRDLAADIVVTDPRVSSVHAVLERGSDGWEIEDAHSLNGTFFDGQRVDRMLIDHDETFQLGHAVNGEQLACSVEGREGQHGRESSGDSGGDTMLVPDPGYQLDDEATVTTPHPGSRPRRVARSSPPAARPSAVVRIVSDTVRIGRASDNDIVVPDLMVSRHHAELRVTGAGRYRVVDLDSHNGTYVNGARVDSADLSESDLIGMGHTTYRLVGDELREYVDTGDVSVSVQNLIVRTAEGKVLLDEVSFPIPQRSLVGVIGPSGAGKSTLLGAVTGLRPATEGTVRYDGRDLYTDYDELRHRIGLVPQEDILHSQLPTRRALLYAAELRFPGDTRPEEREQRVDEVLAELGLARHADTRIDRLSGGQRKRVSVALELLTKPSLLFLDEPTSGLDPGLDKTVMEMLSELAHDGRTVIVVTHSVANLDSCDRLLVLVPGGRLAYYGPPAEGLQQFGQRSWAEVFQSFDREEDRDWAAEFRESPRFEQYVEVGPTDDVGPADVHAPAPPPAPQSKLSQLSTVCRRYLAVIASDRSYLALLGVMPLILGGLIAAVPSGEGFTGAPGTNADAPTKLMILAFGACFIGTGNSIREIVKEQTIYRRERAAGLSAGVYLMSKLLVLGVITILQAAVLFLIGTIGVSMPAKGVFTAVPLELILAMAMLGIASLALGLLVSVSVNTSEKTLPLLIVLSMAQLVFTGGLVRLPGTPVLAQLSYLSPSRWGYAAAAATLDLDTLSPHDGAPDPLWRHSLGTWLLDMGVVAGLGAVFLALAGYRLYQLRPRRRGARTARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6T8</accession>
    <name>A0A231H6T8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44569">
        <property type="protein sequence ID" value="OXR44569"/>
        <property type="gene ID" value="B7C42_03359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="7819" checksum="9D6750DE49B67058" modified="2017-10-25" version="1">MEAKNREIEPGAVWQRSGDGEGGVEVAFLASGNIGLRDAKNPDGPALIFTPGEWRAFVAGAKDGEFNRPGAQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Y6</accession>
    <name>A0A231H6Y6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776038.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44605">
        <property type="protein sequence ID" value="OXR44605"/>
        <property type="gene ID" value="B7C42_03395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="160"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="30863" checksum="FD775375C9D08D93" modified="2017-10-25" version="1">MARSDVLVSADWVEENLNTPGVVIVEVDEDTSAYDTGHIEGAVKIDWKKDLQDPVRRDFVNREQFSDLLSARGIANDDTVVLYGGNNNWFAAYAYWYFKLYGHQNVKLLDGGRKKWELDARPLSTDAVTRPATTYKASEQDLSIRAFRDDAIQAIGVKNLVDVRSPDEFSGKILAPAHLPQEQSQRPGHIPGAINVPWSKAANEDGTFKSDEELASIYKEAGLDGEKETIAYCRIGERSSHTWFVLQELLGHKNVKNYDGSWTEYGSLVGAPIELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7I9</accession>
    <name>A0A231H7I9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF35_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44894">
        <property type="protein sequence ID" value="OXR44894"/>
        <property type="gene ID" value="B7C42_02849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="15715" checksum="149BE83412F439FA" modified="2017-10-25" version="1">MSAPTLQHRSHTGTTASEEVLMIRRCAKCDKLFAPLTAGCSSCASDALERVPSSGAGSIVSWRVVERAGAGGVLAQSTVAIVELDEGPWVYTSLEGEVPLLADRPVRVHFQPRPRDDRFPVFVVCADRRHSESVTSSGSGGRDHAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H879</accession>
    <name>A0A231H879_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kshA_3</name>
        <name evidence="10" type="ORF">B7C42_02893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44936">
        <property type="protein sequence ID" value="OXR44936"/>
        <property type="gene ID" value="B7C42_02893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="350" mass="39282" checksum="5E9A014F20DE6A51" modified="2017-10-25" version="1">MAKPPLSMEPTGWFQVAWCTEIPIGAVHKMKYFGREMVAWRSASGQLAVFDAYCEHLGAHLGYGGRVDGENLVCPFHGWEWNRQGRNVCIPYESHPNKGRRIRSYPVVERNEAVWIWYDIDGRAPYFEVPDIFEAFGDDKTAADYYPPVPAATLFRPGLELHPQYIMENGVDFAHFKVVHKTPFVPEFTRHDFSGPVSYVDFTIAFDEGVSESDVSSGVESINAGLGCSITKSWGMVDNRTMPAVTPVDEYTSDVRFTVWIGRKPGDDSPEISRYGKTMADFVIEQFEADIDIWAHQRYSDPPALSRKEFQGFTALRQWAQQFYPDGGPAGTDPHRPHSGAVVPAADATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8V7</accession>
    <name>A0A231H8V7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amicyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mauC_2</name>
        <name evidence="4" type="ORF">B7C42_02519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45394">
        <property type="protein sequence ID" value="OXR45394"/>
        <property type="gene ID" value="B7C42_02519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13921">
        <property type="entry name" value="Amicyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035668">
        <property type="entry name" value="Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172439" evidence="2">
        <location>
            <begin position="44"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="3">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="14739" checksum="3FE4FC7C5D23C771" modified="2017-10-25" version="1">MAHSTVRNRAARLLPTAGALVAALLIAGCGSNTTTSTPPTTTAATPPGTAPASPTSAQPASVTVHVEDMKFSPDAVTVQAGDTVTWKFSDKVPHAVQGIGDAAMGINSPIFTGGEWSHTFAIPGVYRYLCPLHPEMRGTVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H987</accession>
    <name>A0A231H987_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">B7C42_02516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45391">
        <property type="protein sequence ID" value="OXR45391"/>
        <property type="gene ID" value="B7C42_02516"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="246"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="380" mass="40274" checksum="DBD55BBE63A4897D" modified="2017-10-25" version="1">MSSADPQVETVVDLDAIAHNVRILREHAGDAAVMVVVKADAYNHGAVQVGRAALAAGAAELGVTTISEALELRAAGITAPILSWLNTSDADYAAAIAADIEIGVSSTAHLRAVERAARASGTTATVTLKLDTGLNRNGVSSADYPHVLSLLQELVAERVVHLRAMFSHLAHADQPQHPVIDVQRDRFVEAIAVAKEYGLQPEVVHLANSAATLTRPDLAFDMVRPGIAVYGLSPIPEISDFGLRPAMTFRARVALVKRVAQGEGVSYGHEWIAPHDTTVALIPAGYADGVPRGLGGRIALRIGDAEYPNIGRVCMDQLVVDLGENRQGVQEGDRAVLFGGAPGDPHAQRWAELMDTIHYEIVCSPRGRVVRGYTGQAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9A5</accession>
    <name>A0A231H9A5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metabolite transport protein YjhB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yjhB</name>
        <name evidence="7" type="ORF">B7C42_02563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45438">
        <property type="protein sequence ID" value="OXR45438"/>
        <property type="gene ID" value="B7C42_02563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="424" mass="46395" checksum="5FD25B7F192B8662" modified="2017-10-25" version="1">MTVAGRQRLTSDQRNSFIAAQLGWTMDAFDFFLVVFVYADIAASFDMPKSDVAFITTATLIMRPVGALLFGLWADRVGRRIPLMVDVAFYSVIGFLCAFAPNFTVLLILRLLYGIGMGGEWGLGAALAMEKIPAERRGFFSGLLQEGYSFGYLLASLASLLVMNWLGLSWRWLFALSVIPALIILVIRTRVGESEAWESSREHMRLTQTSLRDVVMNPVVIRRFAYLVLLMTAFNWMSHGTQDVYPTFLSAVENGGAGLSSATAKWIAVVYNIGAIIGGLVFGSLSQRYGRRYTIIFCALLGLPIVPLFAYSTTAAMLCLGSFLMQLVVQGAWGVIPAHLTELSPDAIRGFYPGVTYQLGNLLASLNLPIQERVAESHGYPFALAVTIVPVLIAVAFLTLIGKEAKGIRFGTNESALPETPARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9C6</accession>
    <name>A0A231H9C6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45430">
        <property type="protein sequence ID" value="OXR45430"/>
        <property type="gene ID" value="B7C42_02555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218052" evidence="1">
        <location>
            <begin position="28"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="44808" checksum="BFC88ECCFECB8FD1" modified="2017-10-25" version="1">MKSPTVAAKIIAAIGLAAATAMSSACGTDTDATKVTDPVVDLAQLDVGGYSTKPVDLGLPKNMYVARFMEANRLGNVLPLPYEVDPKLTVGESSDTHAFLDVGPEFHLSEMFRWLHEETFNDAAKNYVAGFSTLGSSNEAYSLSYELVNSVLLFTDNESARNAAEQLSKAEFYKDGPTEQTTLPKYPASIAKWRPVQQVLASWTVDDRYVIVTIADNYENSELGVSDLPFLSDLSQKSIAASIDALRNFTPTPVADLMKVPVDPDKLRGRALRRPEGDSFANVPGIFDLRGALQLAAEPRATEKLYRDNGVDRVAFDAGELLQAKDSKAAQKIFESRTHPDKFMHVVDPPKNLPNAVCLQYKGPEINVRYYCHVRYQRYSAIVWSQQLRDAQQRISAQYAILANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9I0</accession>
    <name>A0A231H9I0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776488.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45515">
        <property type="protein sequence ID" value="OXR45515"/>
        <property type="gene ID" value="B7C42_02640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="44506" checksum="58B5852AB20142E8" modified="2017-10-25" version="1">MSDADPIVVSGFAVEAPGGIETPGQYWAALSQARDLTGPFPRDRGWPLAELLNLSRHEGWAAVCDAGGFLDRAAEFDPMFFGITPREAVAMDPQQRVALRVAWRALENAGIDPAAVDGDEVGCYMGASPTEYGPHGAEVNDYSGYRAAGAALGAVAGRISNCLGLGGPSIVVDTACASSLSAVHMAAAAIRAGECDWALAGAVCVMGSPAAFFEFSKNNALAADGQCKPYSDAADGTLWGEGAGVLVLERESRARAAGRRIYARVLATRVNHNGAGAPIAVPSSRAQERLIRATVAAAGISPEVVGMIEGHGTATAVGDPLELEALDRVYGSGSARLGSVKSNLGHAQAAAGMLGLIKVLLSGLHGQIAPTRFADNPTAEVDWDATGLRLAAKLEDWQPHDGVRYAAVSSFGVSGTNAHALLAVPAEEESHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA79</accession>
    <name>A0A231HA79_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45751">
        <property type="protein sequence ID" value="OXR45751"/>
        <property type="gene ID" value="B7C42_02043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="2">
        <location>
            <begin position="147"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="2">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="30322" checksum="6F84164ADE3ED067" modified="2017-10-25" version="1">MNFASTAPGARHGTVRRAESDDQGPEYDLPTVDIRLGDRVPSMFGEYARRRIGDAARCAPSKVASIRVRLADHRESALANPFVAQADIVAARPMRVQVTGATAREAVDLLQTRTRARLRMPIGGAATQPQRCDPPAATLLYLRPVTQRKIVRTKCFHLLDRTAAEAAADMALMDYDFWLFTESGADTESVLARTTGGHYRLTRLDERAATADAADLPLTVDEAPAPVLDRTKALTRLQLSGSPFLFYRDRELDRGCVFYHRYDGHYGFITSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAJ6</accession>
    <name>A0A231HAJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">(2S)-methylsuccinyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mcd_4</name>
        <name evidence="9" type="ORF">B7C42_02147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.12" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45855">
        <property type="protein sequence ID" value="OXR45855"/>
        <property type="gene ID" value="B7C42_02147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="135"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="416" mass="44942" checksum="8A1439335628F3BA" modified="2017-10-25" version="1">MSTTETVTAATESVDSFRDRARRWLRDTLPPAPPVRSGEQKSPQVWARARELQRILHDGGFAGICFPVDYGGLGLSPAHQRAFTEESRPYEMPLALNIPTLTICAATLLDMGSEEQKRTHIAAVLRGEELLVQFLSEPRGGSDLAGLTTRADRDGDEWVLNGSKIWSSGAYAADYALCLARTDWQVPKHAGLTMFLVPVNSPGLTIRRITQVDGSTEFCQEFFDDVRIPADAVVGEVDGGWAVATRLLHHERSAVGGGSPYASGVGQHSGRDVHSLLDIARRTGQFADPRVREDIGEAHAMNLVHDQLIAHVGARIAAGELAPAAGSMVRLFSARNSWLQADAAVRIAGAAAATGDPGGEPGLGRAGQDYLYRQAWSLAGGSTEMARNIISERVLGMPREYAADRDVPFDQVRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ5</accession>
    <name>A0A231HAQ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiocerol synthesis polyketide synthase type I PpsC</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ppsC_1</name>
        <name evidence="2" type="ORF">B7C42_02099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45807">
        <property type="protein sequence ID" value="OXR45807"/>
        <property type="gene ID" value="B7C42_02099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="17"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="34046" checksum="A3F64EAA9AD5DE71" modified="2017-10-25" version="1">MAGPVTAMRVAVCPRYGPPEVVRVENRPVPEPGAGQVRVRVRAAAVNYPDVLLVANEYQISVPPPFVPGSEFAGEVVALGPGCGEVAIGDRVRGTGLYGAFAEQAVVPATKLAPIPDGVDAAAAAAFGVTYRTAYHCIRSVARVSAGAELLVLGAGGGVGSAAVALGARLGLSVTAVASSPAKLEVAAALGATRLIDHRDGGLRDALRAALPDGADAVVDPVGGALSEPALRSLRRGGRFVTVGYASGTVPRIPLNLVLVKGIHVLGFQFQDLDRAEFDRNERELALLLSDGLRPHIGARFPLSDSAAALRLVADGHAVGKVVIDMDDEEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB37</accession>
    <name>A0A231HB37_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Undecaprenyl-phosphate mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_01031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GtrA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.54" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46068">
        <property type="protein sequence ID" value="OXR46068"/>
        <property type="gene ID" value="B7C42_01031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047267">
        <property type="term" value="F:undecaprenyl-phosphate mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="8">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="9">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="418" mass="45352" checksum="39488F3786AAC46D" modified="2017-10-25" version="1">MAFQAATTPDSTRTPVLEVVIPVYNEERDLAGCVRRLHAFLRDGFPFSTRITVADNASTDSTLAVAHELAAELPEVEVVHLDRKGRGRALRAVWEASDAQVVAYMDVDLSTDLNALLPLVAPLVSGHSDLAIGTRLAKSSRVVRGPKREIISRCYNLILRASLQARFSDAQCGFKAMRTDVARRILPLVQDGEWFFDTELLVIAERAGLRIHEVPVDWIDDPDSRVDIIDTARKDLLGVWRVGRGLATGALPINELRAAIGREPLVDGVPLGMVGQLVRFGIIGVLSTLAYMLLYVMLQSVVGAQPANFAALLITAVANTAANRAFTFGVRGSGNAVSHHFQGLLIFAFAWLLTSGSLFALHRWAPDASVHVELLVLVVANLVATLTRFVGLRWVFRNAVAGSAVEDIATAPAPTETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB84</accession>
    <name>A0A231HB84_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46108">
        <property type="protein sequence ID" value="OXR46108"/>
        <property type="gene ID" value="B7C42_01072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="19537" checksum="D4B94FF2E9DE018A" modified="2017-10-25" version="1">MSEPLIGEPPALDLVNTRPADGDLLQTTGQLTRWLGLQAGRLHGLPGDVTAADLAAVHAVRDHTARILEALLAERVPPTAAVDGLAAAQAAAPAVRTLEWGADGFTATVRRRGEPGTHVAAALADAAVDLLTDPAIARLRQCAADDCVLLFLPAHPRRQWCSPERCGNRARVARYYQRHKGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB99</accession>
    <name>A0A231HB99_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine-protein kinase/phosphatase DegS</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degS</name>
        <name evidence="5" type="ORF">B7C42_01093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46128">
        <property type="protein sequence ID" value="OXR46128"/>
        <property type="gene ID" value="B7C42_01093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="4">
        <location>
            <begin position="46"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="470" mass="49904" checksum="EA5C02D051492328" modified="2017-10-25" version="1">MEAMTETLAEPTLVLDRPDSRPTAGSVLRAILRAPFEARTWKELAYLIVAAILGCLVLAYLFAGYGVGLYSSILIIGAPLLAGVLLGGRIWGRIYRAVGAALLTADLPAPPDFTARPGLVGWFRSVFTDRTAWRALVFLVAEAILGVFVGYVVLTVIAVTVFTAISPIPWAVFHPVNVDPQGREHHSLAQFGDYYIDTWPRVLGLAALGIIGCFLLPWLVRAVCWAHRGLMLTLLTPTARDRRMAELQESRRVAVEDSAATLRRLERDLHDGTQARLVSIAMTLGRAEERLAAGADPAALIADARASSKDAIAELRELVRGIHPPALELGLEPALETLTARCAIPVELRVHLPQRPSPAIEAIAYFSVAELLTNVVKHSGASAAWVSVAPSGAATMMVSVRDNGHGGVRQPGPVARESGSDADAPTERLVGGGLSGLAARARAVDGDLSVDSPVGGPTNITITLPIAGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBB2</accession>
    <name>A0A231HBB2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_4</name>
        <name evidence="1" type="ORF">B7C42_01199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46233">
        <property type="protein sequence ID" value="OXR46233"/>
        <property type="gene ID" value="B7C42_01199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="453" mass="46011" checksum="181FF5AD9C8B6B47" modified="2017-10-25" version="1">MAASKSKGAPNLYGSFVNSAPGAFLAGKLGLPQPEKLRRYTPGEPALPGPVLLGGKGRVADAARTLLSDYTFVDAPTQGVKVGALVFDATGIGTVEELSQLFEFFQPAMRSIAPSGRVLVVGTTPELAGSVDAQIAQRALEGFSRSVGKELLRGATANLVYLHPEAAAAATGLESTLRFVLSAKSAFVDGQVFRVGKDDNAAAGIDWTKPLDGKVAVVTGAARGIGATIAEVFARDGATVIVADIPAAGEALSQTANKVGGTALAVDVTAADAADKIAEFATERFGGVDIIVHNAGITRDKLLANMDAARWDAVLNVNLAAPHRITEGLVAKGALKEGGRVIDVSSIAGIAGNRGQTNYGASKAGVIGMVNAEAPKLAEKGITINAVAPGFIETAMTAAIPVGTREAGRLLSSLLQGGQTVDVAETIAYFASPASNAVNGNIVRVCGQAMIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBG9</accession>
    <name>A0A231HBG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781502.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46211">
        <property type="protein sequence ID" value="OXR46211"/>
        <property type="gene ID" value="B7C42_01177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10332" checksum="F65DF692D5009DB4" modified="2017-10-25" version="1">MLMITPTAIEAVRTITSADGMPDDAGLRISTTDGAETLQLAVAAGPSDQDQVLNAEGPRVFLDEHVVDFLDDKILDTGLGPDGQGTFVLAQQDPNTAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBH6</accession>
    <name>A0A231HBH6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aliphatic sulfonates transport permease protein SsuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssuC_1</name>
        <name evidence="6" type="ORF">B7C42_01160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783287.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46195">
        <property type="protein sequence ID" value="OXR46195"/>
        <property type="gene ID" value="B7C42_01160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="284" mass="30355" checksum="C643D8CE6036E953" modified="2017-10-25" version="1">MTVVSAHLPALGARPAVAAGFTARPARRRLGLRRQIPFARLLGVVLLLAAWSAGAYLGLLDPRKLSAPWTVVTTGWDLLTEGQLLTTIAVSMQRVATGVFLGILIGTALALIAGLSRVGDSLVDGVVQLKRSIPTLGLVPLMILWLGIGNEFKIVLIMLAAAVTLYVPTHSALTGIDRRLVELSEIQGVSRFDFIRQVVIPGSLPGFFLGLRLAVNTSWLVLVVVESVNATDGLGKMMQDAQNYGQADVILVALAVYGIFGLACDSGIRILERKVLSWRQTLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBJ6</accession>
    <name>A0A231HBJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46314">
        <property type="protein sequence ID" value="OXR46314"/>
        <property type="gene ID" value="B7C42_01280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="114" mass="12811" checksum="EE1BE4AD713174CD" modified="2017-10-25" version="1">MEFWPERPPLRRGDAVLSAVVYLAGCGVAWLIWRYGLPYRDMAQQRTRPGPSHLPQAYAAVFLALVGALLLAGRWTLRALRERRPAWRYALLTLPLLAEAWLLGFAVALVVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBN8</accession>
    <name>A0A231HBN8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781702.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46354">
        <property type="protein sequence ID" value="OXR46354"/>
        <property type="gene ID" value="B7C42_01320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="20580" checksum="A14B62388C103865" modified="2017-10-25" version="1">MGKIVVAEFVSLDGFIQDPLWTAPFWCDGIANYKSGELEAVDALLLGRTTYQMFAASWPDHPEEGAYKDKMNSMPKYVATDSLRDLEWNAQRIEGDLAAGIAKLRTEQNLLVFGSASLVTYLREHELVDEYRLVVYPVLLGSGLRLFEAVEPEATLALADSEVLDNGVVLTTYRVSANSVVRPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBQ4</accession>
    <name>A0A231HBQ4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46249">
        <property type="protein sequence ID" value="OXR46249"/>
        <property type="gene ID" value="B7C42_01215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="19391" checksum="80F77D0153DB3F95" modified="2017-10-25" version="1">MDRCAECGYEYRPEEAPRAATAILAGVTELAATLNDCADARRRRLPELWSPLEYGCHVRDVLLVQRERVLLARRTDRPALVTMGRDERADHDGYAEQDPADVAQELLVSARLLANVLDRLDADDWNRRVLYNYPDRVERELRWVAVHTVHEVRHHLLDVRRQLVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBR9</accession>
    <name>A0A231HBR9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aliphatic sulfonates-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ssuA_2</name>
        <name evidence="3" type="ORF">B7C42_01161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783285.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46196">
        <property type="protein sequence ID" value="OXR46196"/>
        <property type="gene ID" value="B7C42_01161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011242096" evidence="1">
        <location>
            <begin position="26"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="82"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="348" mass="37201" checksum="94D003C384348862" modified="2017-10-25" version="1">MRLTRRVGAASFVVLVAACASSACAASGGSADFSKPLPTSVPAGTSLKISATDMKVALTSSGQIDKLPFTVPDWPNVSAGPDVIQAFKGGAVELASNAGIPSIQAHAQGLDTRIVAVLWRSTPNYGLATAPGSTIHNLQDLRGKKIAFSPGQAQGGVVLRTLQQAGLTTSDVTLVQLNSPQFLTALQGKQVDVAPLAEPSLTKYLAQYKSEGAGTVPSDAVDALSILWAPTSVLADDAKLAAVTEFVKFWARAKVWEWENQDRWIADYYVKNQGVSEADGRRIMATTERPYFPDNWDKSIDWEQQTIDLITSSGAFGKSFDAHQLFDRRFEKIAADAVAPQYRTKAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC60</accession>
    <name>A0A231HC60_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsF</name>
        <name evidence="6" type="ORF">B7C42_01302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030514152.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46336">
        <property type="protein sequence ID" value="OXR46336"/>
        <property type="gene ID" value="B7C42_01302"/>
    </dbReference>
    <dbReference type="GeneID" id="66717844"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="96" mass="10979" checksum="29D3888DCEECA15C" modified="2017-10-25" version="1">MRHYEVMVILDPNLDERTVGPNLDKMLSVVSQQGGKIDKVDLWGRRRLAYEIEKRAEGIYAVVDLTAEPATVSELDRQLGLNESVLRTKVLRQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC69</accession>
    <name>A0A231HC69_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxosteroid 1-dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ksdD_1</name>
        <name evidence="5" type="ORF">B7C42_01312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46346">
        <property type="protein sequence ID" value="OXR46346"/>
        <property type="gene ID" value="B7C42_01312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047571">
        <property type="term" value="F:3-oxosteroid 1-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="9"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="511" mass="54239" checksum="9987781A0A7B444B" modified="2017-10-25" version="1">MTDWNEEVDVLVAGSGGGLAGAYTAAREGLSVAVVEATEKFGGTTSYSGGGGVWFPCNPVLQRAGVDDTFEDALTYFRAVVGDRTPADLQETYIHNGARVIEYLESDDSFEFQMFPWPDYFGAAPKARTDGKRHIVPAPLPAATLGELATAVRGPLGTDRLGEPQPKYLIGGRALVGRFLLALSKFPHVSLQLNTPLVELVTEDGAVVGAIVEREGTRVAIRARKGVLLAAGGFEGNDELRRRFGVPGEARDTMGPWGNQGKAHEAGMAVGADTDLMDQAWWSPGMIHPDGRAAFALWFTGGIFVDGAGQRFVNESAPYDRLGRDIIARLDEGAMTLPFWMIYDDSAGPVPPVQASNVPMVDHEEYVRAGLRHSAATLEELAEKIGIPAQALVETVDRFNDFADRGVDEDFGRGDEAYDRAFSEGKSPLVPIRKGPFHAAAFGISDLGTKGGLRTDTAARVLNESGTPIPGLYAAGNTMAAVSGTVYPGGGNPIGASVLFSHLAALDMAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC76</accession>
    <name>A0A231HC76_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pbpA_1</name>
        <name evidence="4" type="ORF">B7C42_01449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46480">
        <property type="protein sequence ID" value="OXR46480"/>
        <property type="gene ID" value="B7C42_01449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127244" evidence="2">
        <location>
            <begin position="32"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="488" mass="50862" checksum="36639B01129F276D" modified="2017-10-25" version="1">MNTPLRRVAMAVMVMIVALLVNATYVQVIKADSLRNDPRNSRVLLDEYSRQRGQISAGGTVLASSVATDDRYKYLRTYPTDPSAYAPVTGFYSMQYGSTGLERSEDSVLNGSDSALFGRRLIDMISGRDPRGGNVVTTINPMMQKVAYDQLTSKGYTGSVVAIEPSTGRILTMVSTPSYDPNQLSTHDGARATQAWESMSADPSQPMLNRAVSQTYPPGSTFKVVVAAAALSMGIKPEDAFTAAPNITLPGTNTTLENYNGTPCGGGATATMHDAFRLSCNTAFAEIGMKVGAAKLKDEATAFGIGPHSGIPIPVADSTVGPIPDNAALAQTSIGQRDVALTPLDDAVIAATVANGGVRMEPHLVDRTQGPDLRDLSTTKPVSVGQAISAPVASQLTGLMIDSEKATAGGTQPRPYQIASKTGTAEHGSDPRNTPPHAWYIAFAPAQNPKIAIAVIVENGGDRALAATGGSVAAPVARAVLDAGLQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCD9</accession>
    <name>A0A231HCD9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigM_2</name>
        <name evidence="8" type="ORF">B7C42_01402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46436">
        <property type="protein sequence ID" value="OXR46436"/>
        <property type="gene ID" value="B7C42_01402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="23158" checksum="17851788D9A158D6" modified="2017-10-25" version="1">MSFEAIASGGTPESSAVRRRSIDPNETTDFELLSAHVAGDRDAFGILFRRHYHRLWQLALRTCRTPEDAADSLQDALLSAHRNAATFRGDAEVRSWLHRIVVNACLDRMRRNKSRPATSLSDESMAEPAVERDDIAQREVKMVVAAALFTLPPDQRAALVAIDMEGYTVAEAAQLLGVAEGTIKSRCARGRKRLEQELEFLRNPGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCE4</accession>
    <name>A0A231HCE4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46623">
        <property type="protein sequence ID" value="OXR46623"/>
        <property type="gene ID" value="B7C42_01597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="7172" checksum="6709EEA41CEF33DC" modified="2017-10-25" version="1">MHKTVNLLGVVEVAEMLGIGRRAVVDLIRTHQLTAKKLPGRTGAYVLTPEDVEAYRKVRDEKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCG3</accession>
    <name>A0A231HCG3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46498">
        <property type="protein sequence ID" value="OXR46498"/>
        <property type="gene ID" value="B7C42_01468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011293529" evidence="2">
        <location>
            <begin position="35"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="31195" checksum="FB967974A2452FA3" modified="2017-10-25" version="1">MRLKKVVAAAGAAVAVLAGMAVSGTAIGSGSASADPGCPSLYVVAIPGTWETGDHKPDHMVGPGMLSGVTRGLPSSTDVDYVSYAATAFPWEGDVYGASKKEATDNARGLIQGMAARCAGTHYAIVGYSQGADAAGDLAAEIGTGLGVVPPDRVSGVGLISDPRRSPTDVQVGPVVGGAGAGGPRVGGFGFLSDRVRTICAAGDLYCSTEDTDYVTRFAGFLAQASGASAANLWRYQLEAGSIIGDLMAHGGVAALQSQLTDDANQQRVEQLEHFYQSGTHTSYGSYSVGGGQTAISWMHNWIAGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCI9</accession>
    <name>A0A231HCI9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46542">
        <property type="protein sequence ID" value="OXR46542"/>
        <property type="gene ID" value="B7C42_01512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="32388" checksum="57E19768B9083995" modified="2017-10-25" version="1">MTAARERTDVRRWIGVLLGLCCGAGVAVQARINGDLGDRLNDGIAAAVISFGSGLILLLVVSGFSGRMRTGLAAIRRSVHAGRLRWWHLLGGLCGAFFVACQGLSVATIGVTAFTIAVVAGQLTSGLVVDRLGVSPAGITPVTPVRLGAAALAVAAVGVAALGRSGGESGSGGGAAYLLIALPALAGLGLAWQQAVNGRLATVGGPVPATTINFATGTAGLLVVEAAQLARIGWPTGFPTEPWLYLGGAIGVFFIAVAALIVRWIGVLLFGLTSVSGQLIGSVVLDVVAPTGTRLSALTIAGCVLTLLAAAIGVLAQGRTTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCR7</accession>
    <name>A0A231HCR7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46700">
        <property type="protein sequence ID" value="OXR46700"/>
        <property type="gene ID" value="B7C42_01675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15475" checksum="85F3F81FA16A614B" modified="2017-10-25" version="1">MNTGTGHVLPARIALDDLGLDYVVTRAITEHMNGLARSLSPLTWRLDRSPITGTRMLSGIADPGSGDDMAQWALALGLERGEAAWSLAYGVGRDDQTDKVTYSGTATIDHQTTAVRVWCYADQAAREAAREETARIRARWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCY5</accession>
    <name>A0A231HCY5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46709">
        <property type="protein sequence ID" value="OXR46709"/>
        <property type="gene ID" value="B7C42_01685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218060" description="Phytase-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="118"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="519" mass="53988" checksum="719458BD0DB3D8BD" modified="2017-10-25" version="1">MGTSHLLRFALAGAVLCAAAACSSGGGEPQWHTDRDRPLVVSLDDLSARTGGGAAVAFGTPAHGRLDRTADGSVRYTPEPGYQGDDTFTVTTSDAVHLYTTDIAPLGEFGGTTVQASGFGSAWTPVPGSAGEFYGLTDRGPNVDGPGKNEKLVPIPNFVPKIGKFRLTGTRAVLESTIDLKNRAGVGFNGLVDTAASTGETMRDLDGHTLPPIDHGLDPEGLVALPDGTFWVSDEYGPFLVHFDASGTEIERLAPGSGLPGELTMRTPNQGMEGLTVTPDGRRLVGVIQSGLQTPGSESAREVPMTRIVTVDLQTRAVAEFVYPLEDPKRKLAVSEITALDDHTFLVDERDGELAPKANKKLWTIDLNGATDIGPRANVPGTRYDPNLGLLVGDTPLETYVGKVSTADGIAALGTAGITPVAKKSNLDLAGLVAGLNPAGAFFGHDKVEGVATTDGGRTLYISDDSDFGLAGSTGSLPPFGLKPKILPDGRQDTGEILRVDTGALPARTTTHTVTVSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD74</accession>
    <name>A0A231HD74_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041769.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46762">
        <property type="protein sequence ID" value="OXR46762"/>
        <property type="gene ID" value="B7C42_01740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011218492" evidence="1">
        <location>
            <begin position="41"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="22932" checksum="705FDBB01FC62FD9" modified="2017-10-25" version="1">MSRRRVQAGVTLTGFVIAAALSAACLIAAALSFTAGRHHSDETRAAAAVSPTTTVAPVAAEAPVQPTGTSVTAAASDEPLVLNKGADQKHQGETVAVGDCVAAVVATPDAGAPVQKTACASTDSRYKITAKAVAGAHCPADADRSVAETLPGGATDTLCLDFNWVTGSCMNIADGSPTPVDCATAAPGRVRVVEIKNGTTDVNSCSDGDRGFVYNERRFVVCVTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDE7</accession>
    <name>A0A231HDE7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775517.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46842">
        <property type="protein sequence ID" value="OXR46842"/>
        <property type="gene ID" value="B7C42_01820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="20842" checksum="E700FC107E08EA19" modified="2017-10-25" version="1">MTVETVTPAWMHQQITAAEYESWSEEQCAGIEIVDGMVVVSPSASKRHNRLARVLANALDAASGPEWNADTDFDVRLQDVPLTNRRPDVVVYRADTIDITPTRPEHVLLVVEVVSPGSETTDRIVKVDQYAKAGIAFYWRVEQAATGVPLIYTYILDPATRAYRTGEMYTGIIKATAPFTVDIDLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDP9</accession>
    <name>A0A231HDP9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_00203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47083">
        <property type="protein sequence ID" value="OXR47083"/>
        <property type="gene ID" value="B7C42_00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="46038" checksum="E4B683769F8CD621" modified="2017-10-25" version="1">MITVRAERRQLLRQQHSDDTRYFPRIPILIGLLLSVSAALLISALHGFLDLQVYRVDTLAWLHHGALYGPPLPVAGHTDLPFTYPPSAALLMTPLAVMPLWLAEIAVTASSLACLWVTIWLVLSRVRPELNPRSKATVVTPVVIAMAALEPVHTTLWFGQINIILMAAVALDCLTEKPRWPRGVLIGIAAVTKLTPAAFVLYLLIRRDWKAAGTAAATAAGVVLAGFVLFPRTSTQYWLHAIVDTGRIGAPYYAGNQSLKGMVYRLGLPESAAAAIWLGLGLAVVAAGAVAMYLLFRAERTAGAAPIAAGNAPAITKLSVAALLVNAAVLLLVSPVSWTHHWVWVAPALVTAALWSTSRSAAAVAGAIAAVTAPFLIGQVLVPGGGDRELTWNWWQHLLGNTYVLVAVTLLGLALTRLLQRRASALPATQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDS2</accession>
    <name>A0A231HDS2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adc</name>
        <name evidence="4" type="ORF">B7C42_01835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.4" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46857">
        <property type="protein sequence ID" value="OXR46857"/>
        <property type="gene ID" value="B7C42_01835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047602">
        <property type="term" value="F:acetoacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="24470" checksum="CAEDE19D98803A86" modified="2017-10-25" version="1">MHSVLGEKVRMPVEIRDADACAATFLVDAAAAREIVAPTGLEPLTVAGRGVCSLVFVRYVDGDLGPYHEFGLTLMVRGRDRDLGVYIPWLPVNQTFTCAAGREIWGFPKEIADIRITPVRRGKRCEVRIDDRLVVAMEVGGGVPSPGGMGGASIAAYTHMDGILRRTPWVMNPSQVRMGLGGTTIELGDHPVAEQMRALGLPKRALFSSRIGLLRMTFEDAVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE05</accession>
    <name>A0A231HE05_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47114">
        <property type="protein sequence ID" value="OXR47114"/>
        <property type="gene ID" value="B7C42_00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="150"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="339" mass="38421" checksum="ED87F5B366F85843" modified="2017-10-25" version="1">MIHRNAPLTVEGRYRLVQRCQVRPIAHVAAEMGLSRQCASKWVNRFRRFGELGLLDRSSVPHRSPTATPAEVVARIELLRRQRKWSARRIATELRSEGTMISVRTVTRHLHRLGLNRRRFLDPAGASNRAPRRIIARRPGHMVHVDVKKVGRIPDGGGWRVHGKGSDQDKAVARAKKRGTRTGYVFLHTAVDGYSRLAYTEALPDEKAITAIGFMFRARAFFAAHGIGHIQRIVTDNGACYRATDFAKVLLGARHQRITPYTPRHNGKVERYHRILAEEFLYAREWNSEHQRTEALAVWNIHYNYHRPHTAAGNRPPASRLHTGVTNVTASYSPTGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE52</accession>
    <name>A0A231HE52_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpP2</name>
        <name evidence="5" type="synonym">clpP</name>
        <name evidence="11" type="ORF">B7C42_00261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777019.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47139">
        <property type="protein sequence ID" value="OXR47139"/>
        <property type="gene ID" value="B7C42_00261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR47139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="222" mass="24223" checksum="F348D88EF561F31C" modified="2017-10-25" version="1">MTLIDPRAGLSGSAPASPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPGGSFTSLMAIYDTMQYVRADVATVCLGQAASAAAVLLAAGTPGKRACLPNARVLIHQPSLEGGIQGQVSDLEIQAAEIERMRRLMETTLARHTGKDADTIRKDTDRDKILTADEAKDYGIIDTVFDYRKLSAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE59</accession>
    <name>A0A231HE59_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777052.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47174">
        <property type="protein sequence ID" value="OXR47174"/>
        <property type="gene ID" value="B7C42_00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="25384" checksum="65C5CC4BE982CE26" modified="2017-10-25" version="1">MSWSFTPDEFAHIWRETDLDRHPFPLRILETPRTEDEAATLRTTLEARLPLGADPDLSACLRILAAPHTRVVAIGGAHSPGTEIRAVAAAIYDHAVLAIQEPGRTPGFGGSIRLSIGHTAKLGARIAALLPDCPAGGEPARSAPAEAVRDDDCPRPASPPAPRIRRLLLKPHSAEGHIRIEAGLDRPTPPAPLYYTWIDVAEDGRYLIKAGDEVHIVPASRQQIGTHLQKRIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE65</accession>
    <name>A0A231HE65_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-3-phosphoglycerate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gpgP_1</name>
        <name evidence="2" type="ORF">B7C42_00362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47240">
        <property type="protein sequence ID" value="OXR47240"/>
        <property type="gene ID" value="B7C42_00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="27770" checksum="ED7E5FCFBCF96091" modified="2017-10-25" version="1">MNRGPEGGTARDPEVSGERAVDSDVSDASEGVAPAAGSRASKYPGVRRLILLRHGQTEWNAADRMQGQIDTELSELGRRQAKDAARELVSQDAVAIVSSDLRRAYDTALALAEHSGLEVVRDARLRETSLGDWEGLDHLEVDARYPGARKAWRLDPTVTPPGGESKLEVGARALPVVRELFAERADWPGRTIILVAHGGLIAALTAALLELPEHKWPILGGLANTSWVQLSSHGPGIEQPGWRLDVWNAAAKVAPDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF21</accession>
    <name>A0A231HF21_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47540">
        <property type="protein sequence ID" value="OXR47540"/>
        <property type="gene ID" value="B7C42_00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013076436" evidence="1">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="105" mass="10111" checksum="538C6CEBB679566A" modified="2017-10-25" version="1">MTITRRTVHILCAAALLGAAPLAVASPATAAVVPLIPEAATAPDRVDSAAPTGFTGPIPTGSTDAAFGSVDSGTPIISLLPAIPYLANWAVTGSSGCINPGGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFE0</accession>
    <name>A0A231HFE0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="11">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="11">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">gatB</name>
        <name evidence="13" type="ORF">B7C42_00518</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47395">
        <property type="protein sequence ID" value="OXR47395"/>
        <property type="gene ID" value="B7C42_00518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="12">
        <location>
            <begin position="345"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR47395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="495" mass="53666" checksum="9EE948514ED2A313" modified="2017-10-25" version="1">MDYADVIDRYEPVLGMEVHVELGTETKMFCGCPTAFGAEPNTQVCPVCLGLPGSLPVVNQQAVESAIRIGLALNCSITPWGRFARKNYFYPDQPKNYQISQYDEPIATDGYLDVVLDDGSVFRVDIERAHMEEDTGKSLHVGGATGRIHGASHSLLDYNRAGVPLIEIVTKPITGAGERAPEVARAYVTALRDLLKALDVSDVKMEQGSLRCDANVSLMAKGAKEFGTRTETKNVNSLRSVEVAVRYEMRRQGAVLSSGGTVIQETRHFHEGDGSTSPGRVKETAEDYRYFPEPDLEPIAPDADWVEKLRGTIPEYPWLRRARIQAEWGLSDEVFRDLINAGALDLIIATVDAGTTVDAARAWWVNYLTEQAKEREVALEDLPITPKQVAEVVALVDAKTINSKVARQVVDFVLAGEGDPGQIVEAKGLGMVSDDSALQSEVDKALAANPDIADKIRSGKVQAAGKIVGDVMKATRGQADAARVRELVLAACGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSC5</accession>
    <name>A0A231GSC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000729">
        <property type="protein sequence ID" value="OXR39533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39533">
        <property type="protein sequence ID" value="OXR39533"/>
        <property type="gene ID" value="B7C42_08399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7513" checksum="6D9BA4616FC4F732" modified="2017-10-25" version="1">MPAVVETAMCGGFFGFSDLLKPSNSLMLRPSWAIEMRAPLQASCEEPPPMDTKLSQPCCWYSATASITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSE7</accession>
    <name>A0A231GSE7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000578">
        <property type="protein sequence ID" value="OXR39550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39550">
        <property type="protein sequence ID" value="OXR39550"/>
        <property type="gene ID" value="B7C42_08382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="69" mass="7692" checksum="7B38C08DB0B37409" modified="2017-10-25" version="1">MVDEVRALDRAASVETVRGLQHVLHFLDGELEATVCTGERRRELARLRRIAGITLAEAYARAVLARDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSL0</accession>
    <name>A0A231GSL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000169">
        <property type="protein sequence ID" value="OXR39604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39604">
        <property type="protein sequence ID" value="OXR39604"/>
        <property type="gene ID" value="B7C42_08328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="54" mass="5614" checksum="3124077632F06E19" modified="2017-10-25" version="1">MASALLCNSFAGASLRSAVPTAGKGNRQVTRAAVEFYGPDRATFLGPFTDSPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSQ5</accession>
    <name>A0A231GSQ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000101">
        <property type="protein sequence ID" value="OXR39654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39654">
        <property type="protein sequence ID" value="OXR39654"/>
        <property type="gene ID" value="B7C42_08278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="490" mass="54136" checksum="8A6C6A2FB66D0370" modified="2017-10-25" version="1">MLRAHLEAVVFDGAQAEVMELPLPAGAGAPAPGRGPRSHRSDLVDSQTPQRQTQRQIQVLGHIRARLHHRAHLLPRIPAQRHVRSVHVPHRPTELPRPQQQLLAEPQEKPDRRIVIRAQPGHRGGVGVGAEVVADGGGPVVVDEGVGIGAGDEFATRLVESGIARRGDAAHQLMNQLHLRMRAGEFVDNGCGVVDTAVVDHDHLVDRILGDQPRQGSLDDASFVESRNYHRQDHQTSPATREWMNRSRGRALASGNHKPQPCAALDFPKHRRPARSHGDPNPSCRGLDGTEYSQRGHRFPHPIPRGYGRSHQQCCGRSEFAGRSSWPTAPMNRRHVGSSGYRRSAGGRADLAAFERATQFRDGADAVSGTLDDVADQLGESSSDRLLHRIRQSHEYRVGRRGGDLLLLKNGREMSVKILCANCNSRWIEPIEKAAAPILESTMRGERFPPARDLFRQAHWSTVVGRPRRRPTRTRGRGLTTWATQSTTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT10</accession>
    <name>A0A231GT10_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">parA</name>
        <name evidence="2" type="ORF">B7C42_08211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000080">
        <property type="protein sequence ID" value="OXR39718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778741.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39718">
        <property type="protein sequence ID" value="OXR39718"/>
        <property type="gene ID" value="B7C42_08211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="38394" checksum="3A046113F2120930" modified="2017-10-25" version="1">MAKTISLFNNKGGVSKTTTCFNLGWMLASRGKKVILVDADPQCNLTGMVLDLSGEDALDDFYRTNPGRNIKDALEPAFKSRPVPLTPVDCMEVSGCPGLYLVPGHVALAEDETSLGISQQLSESLQGLRNLPGSFHHLFAITADRYNADYVLIDLSPGLGAVNQNLVATSDFFLVPCSPDVFSVMAIDSLARVIPRWISWAHRASALEVLADADYPFPAPDLKFLGVLVQRFRLKSGKPTIAFQKYFDKLNEAISSTFVPALARSGSIFQDEKYAEAGLDSHYVLAEIPDFNTLIAHSQQERKPVFALTQEDIGRAGKLWGNQQANIENYKNTFTQLADRIELLTMSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT63</accession>
    <name>A0A231GT63_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782212.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39814">
        <property type="protein sequence ID" value="OXR39814"/>
        <property type="gene ID" value="B7C42_08102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="71" mass="8104" checksum="B1F799972CF2D00B" modified="2017-10-25" version="1">MAYLTNREAAELMHVHPGTLTQWRNKGRGPKFIKLGDGKQPRIRYTDTDVKAWMDQYNMTPEARDKAGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT96</accession>
    <name>A0A231GT96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000063">
        <property type="protein sequence ID" value="OXR39802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39802">
        <property type="protein sequence ID" value="OXR39802"/>
        <property type="gene ID" value="B7C42_08131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="44" mass="4965" checksum="9EE07B0F1A74D8D7" modified="2017-10-25" version="1">MATSYAPRSGLRTVQHSAVSILGEDMHVREFVHDARHFMVLACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTZ0</accession>
    <name>A0A231GTZ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_07842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043572.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40087">
        <property type="protein sequence ID" value="OXR40087"/>
        <property type="gene ID" value="B7C42_07842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="DUF4203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="DUF4203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4203" evidence="6">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="21504" checksum="536ADAF16C036F90" modified="2017-10-25" version="1">MNGIVVALVGALLCFYGIRSVHLGILAIGFGLGWLIADLFTSSFLWLLLFGAIGALSAWVVTSLIFRFAAYVIGGLTGAMVGAKLASVLQPGDKNWALSMIVILAVGVAGGFLADRFRARALLWLTSIGGASMVLSGIGRMNEHLSFLRAPDSTWQQIFSALAWIALSAAGWIVQRHLFAEKLGIDHLAGRDEHDGGGAVATGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU12</accession>
    <name>A0A231GU12_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043599.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40068">
        <property type="protein sequence ID" value="OXR40068"/>
        <property type="gene ID" value="B7C42_07872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="30434" checksum="8134AA285632218D" modified="2017-10-25" version="1">MAPAYPDFVTFAEQWLFPFITVRLAEANREHTWTWCSQWWRHRAVAVRIAHLHRAFEAMRADKNAAGLSTFILHHLDSHFGVILDAANGPLHRCTRTKHVALPSLSCEPVPPGWFKPPVKPDTESSNTKPYRFGHYADFVEQWLLPVTAVRIAANHREDQYTWCRRWWDHRSVAVRLAGLHVVFEAARIAEDRSAMSTLFVSHIDPHLRYILDAVNGPLHRCCPDRHTPETGLPTADVPANWFATLGNTAPTEDLGFGPDFRGNAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU97</accession>
    <name>A0A231GU97_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40200">
        <property type="protein sequence ID" value="OXR40200"/>
        <property type="gene ID" value="B7C42_07714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="57" mass="6408" checksum="11E1BCB0F7248F92" modified="2017-10-25" version="1">MSRLLTEKEVRELIPVGHSKYYELIGTGELRSVKVGRRRFVTEQAVAEYISALDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUG0</accession>
    <name>A0A231GUG0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MobC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40264">
        <property type="protein sequence ID" value="OXR40264"/>
        <property type="gene ID" value="B7C42_07689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="3">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18375" checksum="ED030D3EC6F2FA22" modified="2017-10-25" version="1">MVAEQESVGRRRRSQEISRERARRRRPNIVGPKRSVMVMVSESEYATLKAAADEAGATVPWYLVESALNPPAATAKPGRKAGPWLAWPKRKALADTIVSLSGLLAEIVLRDLSHVGANLNQLTRAANIDGVVGEELGDVIEELADTVAEIRDRAERLEKMAKEVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVS2</accession>
    <name>A0A231GVS2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40727">
        <property type="protein sequence ID" value="OXR40727"/>
        <property type="gene ID" value="B7C42_07151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12625" checksum="799EDE4D94040381" modified="2017-10-25" version="1">MRIDAIGYLRRDVSGVRQPWDEIQIRSLAKRLGYDLRKIITFTTEVDDVGLRVRNIAARLGVEAVFVPSVDHFEGGVVPAKLVEVVDVITVEPEYTYARWASGELPAEIGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW31</accession>
    <name>A0A231GW31_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisN_2</name>
        <name evidence="11" type="ORF">B7C42_07090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40806">
        <property type="protein sequence ID" value="OXR40806"/>
        <property type="gene ID" value="B7C42_07090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR40806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29072" checksum="83B11BAB8E11AB5B" modified="2017-10-25" version="1">MAPTGCADYGCRVSDHAGDLELALQLADAADAITRDRFGALDLKVNSKPDLTPVSDADLAVERALREILIDRRPHDAVLGEEFGGEAEFIGRQWVIDPIDGTKNFVRGVPVWASLIALLQDGVPVVGVVSAPALSRRWWAATGSGAWTRFEAGEPKPITVSEVGGLNSASLAISSLSGWRDLGLRDQLIELTDQVWRTRGYGDFFGYCLLAEGAVDIATEPEVSLWDLAPLDVLVREAGGRFTALDGTPGPHHGSAVATNGLLHDSVLAALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW79</accession>
    <name>A0A231GW79_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40828">
        <property type="protein sequence ID" value="OXR40828"/>
        <property type="gene ID" value="B7C42_07112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="27870" checksum="E296D269AE167246" modified="2017-10-25" version="1">MQRPSPARMYDALLGGSHNFEVDRWAAAEGRKLVPDLPRLALSNRAFLRRAVRFMIDSGIRQFLDVGSGIPTAGNVHEIAQDIDPSIRVLYVDIDPVAVTHAATILHGNDHAGAIEADLRKPEELLTRARETGLIDFDRPVGLLLVAVLHLLQDEERPREQVAALRAAVAPGSYIAISHLSSAHRPEAAARIHEESTSGVGIRFRDRASIVDMFTGWEPVEPGVVELPLWRPESGRDLHETPGRSLGLGGVGHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWA1</accession>
    <name>A0A231GWA1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase</fullName>
            <ecNumber evidence="4">1.14.99.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ncsB3_6</name>
        <name evidence="4" type="ORF">B7C42_07185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.49" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782947.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40761">
        <property type="protein sequence ID" value="OXR40761"/>
        <property type="gene ID" value="B7C42_07185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="423" mass="46016" checksum="C2014E4F493CB233" modified="2017-10-25" version="1">MTTSQFPTRPTMCPVAHGSPTSSDGPRVPLYTPDFSDDPHRVYREMRSRYGSLAPVELAPGVPATLVIGYRTAVRILNDPEHFPADPRVWQQTVPSDCPILPLLEWRPMASRSSGADFHRYREAITAGIDAVDLHSLRAAVEKATLPLINSFCQDGQAELITQYIYPLAFELVNVMLGCPPEIGAQVAAGTAKLLEGVDAEQGNRILGEALMSLVRLKRATPSNDITSVLQQHPAGLDDTEVSHHVSQIYGTGIEFELNLIANTLLLVLTDDRFGGSVLGGNLSSRDAVDEVLFNDPPLANLLITYPRQPMLIDDVWLPANQPVVISMSACNNDPVIRSDDMTGNRSHLAWGIGPHACPAQSIAYLIAQEAIDQLLDALPEIELATDAPSWRPGPFHRALTALPVTFPRTEPLNLNNKPAMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWJ2</accession>
    <name>A0A231GWJ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase-associated protein RapA</fullName>
            <ecNumber evidence="3">3.6.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rapA_3</name>
        <name evidence="3" type="ORF">B7C42_06945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40979">
        <property type="protein sequence ID" value="OXR40979"/>
        <property type="gene ID" value="B7C42_06945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="123"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="400"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="570" mass="61126" checksum="0AAC9384F44176F0" modified="2017-10-25" version="1">MTEPPPHGARESVRLAVPGPGAATIEVSEVACTVIDADRLDAVEVGHAGSSLSAWQRMAREAGGPELLPAAGHAVPNAAATAIVSADRAVRAYRETEEVVRALRAPLRARLRPYQARGISWLHRTTAEYGGAVLADEMGLGKTVQAIGFLLGRADGGPQLVVCPTSLVGNWVHEISRFAPGLRPLAWRGGELGDLASGAVIVTGYPTLRGYGPALADIDWATAIFDEAQVLKNPRTQVSRAARGVSARARVALTGTPVENHLDELWALLNLVTPAAFTHKAQFRRRFVRPIEEGSTAAVRRLHDTIEPIVLARRKLQVAATLPPKIHTDLVCDLTTEQQRLYDELLDRAEADGFGVGAERNARVLAALTALKQVCNHPGLVTGDLDELTGRSGKFDVCSDILANNLELDCPTLVFTQYRRTGELLARHCAERFAVAAPVFHGGLSQAERDAIVTTFQSAEGPPILILSLRAAGTGLTLTRAADVVHYDRWWNPAVEAQASDRAHRIGQTRPVTITTLTSATTVEEHIAGMHDRKSALAGLGAGDGRSAVARLARLDDDHLLAVLRRKRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWL0</accession>
    <name>A0A231GWL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil(1939)-C(5))-methyltransferase RlmD</fullName>
            <ecNumber evidence="7">2.1.1.190</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rlmD</name>
        <name evidence="7" type="ORF">B7C42_06921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.190" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40955">
        <property type="protein sequence ID" value="OXR40955"/>
        <property type="gene ID" value="B7C42_06921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="440" mass="46881" checksum="06A1BE8C9AABD700" modified="2017-10-25" version="1">MSAGPDWSGRTLQVRLGPPGHGGFCVARYEGRVLFVRHGLPGELVRARVTEDRGGSFCRAEAIEILEASPDRVAPNCPVSGPGGAGCCDFAFATPEAQRGVKAAVVREQLQRLAHWDTDIVVEPLPLGPADETVAAGAAPERSAEAPETGWRTRIRLVVDAEGRAGVHRYRSSDVIADLRCPQPVSGAVDGIAESRWTPGAELVIAVDADGMRHVVELAPPATPPRRGGDRRATAARRAAAHARRRERVVSGSGRAVQYVAGRRWDVSATGFWQPHRDAAQRYSDVVAGWADLDPGSTAWDLYCGVGVFAARLAEQAGPRAVVLGVESARSAVADGAAALRDLHAVDLHAERVERWIAGQDRAPQVVVLDPPRAGAGKQVIVPLTAAAPARIVHIGCDPAAFARDVGLYHEAGYRVRELRAFDAFPATHHVECLALLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXE3</accession>
    <name>A0A231GXE3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulatory protein NarL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">narL</name>
        <name evidence="6" type="ORF">B7C42_06692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41294">
        <property type="protein sequence ID" value="OXR41294"/>
        <property type="gene ID" value="B7C42_06692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="310"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="382" mass="41481" checksum="95B839675995D5EB" modified="2017-10-25" version="1">MTVQSATTRTRPGSDAHVAEQAFTRLLELIGPDPELLRLQDFNPSLSLVRDYASRALRIGLPAPEVTAEVATILMTVDKAIRADIARRIHVHSKQFGGLTRVVRAIDSARNASLSSVLTSELCTALGYGKAMYSVVSGSHWSPVSVSVNPELGHDYDPLVAAVDGRSIPLRDAPREAELVRRRRSYAVGPAEVNRHTYRPLLDLSRPAGYLAVPIVVANRAVAIVHVDRHDNDLNEADFHLITTLAQACALSAESAQLHASIAEQNRRTTEDLNKLQRALRELEDPKVAFDDLEGKPVEHSTELEFATRATHYPTALTARERDVLALIASGATNGAISRQLCISDGTVKSHVQRIFKKIGVSTRAEAAALYAGHRSPPGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXP8</accession>
    <name>A0A231GXP8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC_dehydrat_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41301">
        <property type="protein sequence ID" value="OXR41301"/>
        <property type="gene ID" value="B7C42_06699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="16603" checksum="717F08747321598D" modified="2017-10-25" version="1">MTSPTARQLPVGSVLDVASFEVEAGKIREFATATHALDPVHTDTAAATEAGFTNLPATPTHVVVAGHHRNQQQFVRDLGLAIERVVVGSVEWHYTRPPVVGDHLTGTRRVVDDTTKDGKRGGTMRLVTLETEWTDSAGDRVLTQREVLIERGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXT5</accession>
    <name>A0A231GXT5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780335.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41443">
        <property type="protein sequence ID" value="OXR41443"/>
        <property type="gene ID" value="B7C42_06586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="399" mass="41064" checksum="DB2B0DE1FD6BB428" modified="2017-10-25" version="1">MIAGTPVLDLDDVASLEAADSGGILRSAASGGAQVRATAAAVAENALGRLDGLRPRSLVLVSGTGRAARAATLLQAAFGDRAGLPIISATTIPQWVGSLDVVVVAGDDSADPRLTGAVDRALRRGAEVVVAAPDEGPMRAAAAGRAAMLPPRIRVLDHNRMLRFVAVGIAVLQAVDPVHIGPLVPNLDELADVLDAEALRDGPHHEVFHNPAKTLAARMRERRLVLTGDSPAAAVVAEHGAEVLLQTAGQIAAAVDLTEAVAANARLIESAEATAPGYDPLFHDEQLDGPAPVDRARVFVVSADGDQVAARRRLAVFGAGAGIVDADLVNVDIELMRTEASVPRDTDAGEPPAPAAGRGSEVEQLAVLVLRLEMAAAYLRLLGGPPAASRPAHYDGGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY06</accession>
    <name>A0A231GY06_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41480">
        <property type="protein sequence ID" value="OXR41480"/>
        <property type="gene ID" value="B7C42_06372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="25267" checksum="B0E517A2CE305CF6" modified="2017-10-25" version="1">MVSEGPVPTLFRDPGIPDGEKCRYTVATDGRRSGFELTSVVTHENGGYRTLLEASSGDGELELTIDQRFGRIGGFLRAEDYRAETRSSGVVVSREEAHFIDTVHLPIGGAPAPFPTDIMPIVGGMTLLRGLDLTEGAAQSIDTWLAFSVHWPLVARVDKRAVVAVGAGEIECRQVRLRPSFGQVNMLLDKMIGGLLPPFVVHIEVEPPHRLVRSSFPTELALSAPRSVIELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY73</accession>
    <name>A0A231GY73_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780895.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41567">
        <property type="protein sequence ID" value="OXR41567"/>
        <property type="gene ID" value="B7C42_06460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011278875" evidence="1">
        <location>
            <begin position="37"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="130"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="336" mass="35433" checksum="D0F6A6FDBC9DA82A" modified="2017-10-25" version="1">MRSVASIAWRMVAFALAMAGLLAVVVQAIQRPVADADVTYTAVFTDANGLKTGDDVRMFGVAVGKVESISLDRDYRARVRFTVQPRHPVYLTSTVAIRFQTLIGQRYIDVRQPNSPGAAQPPGVDIPTARTLGSFDITALFNGLQPVLAELSPAAVNHFAETILAVLDGGGSGLGPALDSIERVSSYVKDRQSVLAVLVANLRQVADRIDGRAQNAIVLLDGIDHVFGALEQKLDGLVDFVVTAPSVLTPIDSLAATLGLTPGDNPDLAQAVHTAFPDPHAAADVLARLPGLLQSLDAVVPRTGQEVNRTCSHGNADVPGALAILLNGTRISVCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYN3</accession>
    <name>A0A231GYN3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41717">
        <property type="protein sequence ID" value="OXR41717"/>
        <property type="gene ID" value="B7C42_06059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="322" mass="34090" checksum="D2785F1937EEFEFD" modified="2017-10-25" version="1">MSLGRPIGRIGLQSVGDLPCLRGVAATHIAVVREPPVRWPESCGGMGEGGAVAQVIDQRAAVGVSVVRSRHCRTDPPENRFGLRQRPQSIVGRSEFLRRPAADAIVGPRQPLPTGVGGGLDEVGRSADVVTDEGRVGRIHLDRSQRRADVVEVPEQGGAVGRGSAAGAVDDDCEVTAASCGNTLCPVDECAIEIIDRHMIDIGLQGIETANEEQGHTGCAGGFDEQARSLQPGAVRVFRIADDAGGRHIRHRFGNRAKLARPTGAGDMSGKLEQRPTCRNEPQRSRRARDTDPLSACYRLLERDSTGHSTESAGAVTAGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ08</accession>
    <name>A0A231GZ08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41849">
        <property type="protein sequence ID" value="OXR41849"/>
        <property type="gene ID" value="B7C42_06191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="15126" checksum="C0981423F1D636C5" modified="2017-10-25" version="1">MKAQVEALESLLRKLPDPTTPAPLPSARSKPGRARQLGTDQVQELVTGYMSGETVYQLGNRFGIARRTVSEILHRHGVPMRRRGLTAEQVDEAVHLCGLGWSLARVGRHLGVDGMTVLNRLRERGVPTRDPQGRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H065</accession>
    <name>A0A231H065_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aliphatic sulfonates-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ssuA_5</name>
        <name evidence="3" type="ORF">B7C42_05838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42239">
        <property type="protein sequence ID" value="OXR42239"/>
        <property type="gene ID" value="B7C42_05838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="34073" checksum="6BCFE3766C6D2A13" modified="2017-10-25" version="1">MTVRVGYFPHNNSLFVLRHRGILERALPDVEWVDLRALPQPPRADVKTALPSVHSDYLFDANGYDFIGTGFTPPITALGNDRDIVYVGISGPRIENGRLVTKAGNGIESVADLKGKRVGIAHGSWQTTLLLFALERSGLGWGDIEPVDTDVHDGGALLLDGSLDAWVGAYPGLAAVEAATPLHTLVDTESVFSHPSLWFTRRDFAQAHRPALEAIITALRESDAWIAENPRAAAQYFVDDIVARGGTADLDAWEAALRGRPFGLGPVTEQFLDEQQHAADLLHAKGLLSKKIRVRDAVDPTIAQFLTAPEPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0G1</accession>
    <name>A0A231H0G1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42333">
        <property type="protein sequence ID" value="OXR42333"/>
        <property type="gene ID" value="B7C42_05532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="17622" checksum="DB3686B9AFB67A3D" modified="2017-10-25" version="1">MSEAAPQSDRTDPDGRTADAATGATAAGSDRVSNRYGTGPVRNRRWVPIALGIVVVILGLIVAYVGYRQYGPKDIEPDQLGYDVVDDSTLTVHFKLTRKNPEQPVVCLVRGMDTEGSEIGRREVLIPGSDSGTVELTTTVRTTARPANGNIYGCSDQVPAYLKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0I4</accession>
    <name>A0A231H0I4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Demethylrebeccamycin-D-glucose O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.164</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rebM</name>
        <name evidence="2" type="ORF">B7C42_05568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.164" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42369">
        <property type="protein sequence ID" value="OXR42369"/>
        <property type="gene ID" value="B7C42_05568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102082">
        <property type="term" value="F:demethylrebeccamycin--D-glucose O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="25779" checksum="8FC9743B79358C95" modified="2017-10-25" version="1">MSDDLSVSGIDPTTVDFEQLYSGAALAPGLRLEKPPWDIGRPQPLLIALERAGRITGEVLDIGCGPGDTAVHLAECGYRVTGADIAPTAIDQARARAAGRDLPVTFAVADATILAGYDNHFDTVVSSALLHCLSPTQRRSHVAALARVTKPGGRLIQFSFAATEHAHLYAPYPLSEPELRSEFTTPEWDITTLRPEFIEAVNPPEEVRKLFVSKGFHPEKDETGGLRLPVHLLEAQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0X6</accession>
    <name>A0A231H0X6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ECF RNA polymerase sigma factor SigI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sigI_5</name>
        <name evidence="7" type="ORF">B7C42_05301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42525">
        <property type="protein sequence ID" value="OXR42525"/>
        <property type="gene ID" value="B7C42_05301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="391" mass="42468" checksum="A2BAE78BFDEEC652" modified="2017-10-25" version="1">MNESLLRELVPAVIGVLVRRGADFASAEDAVQEAVIRALRTWPDDPPRDPKGWLVAAAWRKFLDATRAETSRRERELAIEHEPPTGPVPGADDSLWLYFLCAHPSLSPGSAVALTLRAVGGLTTRQIATAYLVPEATMAQRISRAKRRLAGLPLDRPADPATVLRVLYLVFNEGYGGDIDLAAEAIRLTRQLAAATDEPEVAGLLALMLLHHARRSSRTGPDGRLVPLAEQDRTRWDTRLIAEGVAILQAALARDRLGEYQAQAAIAALHADAPTAAETDWVQIVEWYDELLNLTGSPVVRLNRAVAVGEADGPQAGLAELNTVDPGLPRYAAVHAYLLERAGDLEQAADRYAAAAGTATSVPERDHLTREAARVRGLLRRRTEQPTTFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1P1</accession>
    <name>A0A231H1P1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042098.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42758">
        <property type="protein sequence ID" value="OXR42758"/>
        <property type="gene ID" value="B7C42_05096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17663" checksum="F17BE45B04942A88" modified="2017-10-25" version="1">MTLHITDWLMTSDVTPESAQRLPSLPGRWLLSWLPGELLTQEQALSGMILDEILSDPAFVDDLGAVEMATLHAAELGITLDEAVIRLCARVLERTARRSGDIGPDDIEPGDIEPGDIGPGDRGASATEYGPVRGHPHLPHVHRTPVSLHRPRHTDHDLSAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Q5</accession>
    <name>A0A231H1Q5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780239.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42776">
        <property type="protein sequence ID" value="OXR42776"/>
        <property type="gene ID" value="B7C42_05114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="13117" checksum="BBFBF001A818D939" modified="2017-10-25" version="1">MTRPGRDDSPDRLYTLTGGRSHPDTDAFDLVTLVVAESAPVPGMQSEQVAILEICRAPTAVVEIAAELRLPVGITMVLLADLLDAGKITVRHPRSAPAWEPWKALPDTEILEKVLVGLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H215</accession>
    <name>A0A231H215_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dhbF_6</name>
        <name evidence="10" type="ORF">B7C42_04780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42894">
        <property type="protein sequence ID" value="OXR42894"/>
        <property type="gene ID" value="B7C42_04780"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="760"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1813"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="795"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="2594" mass="280564" checksum="A34EB8A436C4FE1E" modified="2017-10-25" version="1">MPEHLDLPTDRPYPATSDQHGAVVTIEWPAELQQQITHVAREHNATSFMVIQAALTILLSKISANPDVAVGFAVAGRDDPALDDLVGFFVNTLVLRVDLTGDPPFTDLLTQVRTRSLEAFEHQHVPFEVLVERLNPARSLMHHPLIQVLLAWQNFAGNNDPAAGLVLEDLDVTSLPLDTHSARMDIAFSLGERFTDTGQPAGLTGAVEYRTDIFDTTTINTLIHRLQRILVAITTDPEQPLSSVDLLDESEHTRIDEFGNRAVLRTSRSSSPSIPALFAAQAARTPDAIALSCGDRSYSYRQLEQAANRLAHLLTDRGVGPGCVVGILMERSAQAITAIAAVLETGAAYLPIDPEHPRARIEFMLTDATPVAVITTNDLARRLNGIDIPIIDVNDPALDTQPGSPLPVPSPDNIAYFIYTSGTTGTPKGVAATHHNVTQLLASSDVTPTSEKVWAQCHSLAFDVSVWEIWSPLLHGGRLVVIPDQITRSPTDFHDALAAEHVTVLTQTPTAAAMLTPQGLESITLILGGEFCPAQVIDQWAPTHTVINGYGPTETTMCVTLTTPLTPGSGAPPIGAPVPAAALFVLDEWLRPVPVGVAGELYVAGAGVSCGYWRRPALTASRFVACPFGGTGTRMYRTGDLAHWGTDGQLHYVARADEQVKIRGYRIECGEIRTALTQLDGIEQAAVITREDRPGDKRLIAYITGTANPTDIRTQLAEQLPTYMIPSAIMTLDALPLTVNGKLDTRALPAPEYSTSGYRAPSTPVEEILTTIYARILGLDHVGVDDSFFDLGGDSLSAMRLIAAINTTLDTDLSVRTVFDTPTVARLAPSIDNADTSRLPRLTPIERPDAVPLSYAQQRLWFIDQLQGPSAVYNVAAALRLSGGLDVDALGAALADVVGRHESLRTVFSATDGTPRQVVIPADRVPFECEVVDAAGWSQTRLDAAVNEAARYPFDLATEIPLRAMLFDVSGHEHVLVIVMHHIAADGWSLGPLATDLSAAYAARCAGRAPGWAPLAVQYVDYTLWQRTQLGELHDPHSRITTELEYWEHTLAGMPEHLDLPTDRPYPATSDQHGASVTIDWPAELQQHITRTAREHNATNFMVIQAALTILLSKISANPDVAVGFAVAGRDDPALDDVVGFFVNTLVLRVDLTGDPNLTDLLTQVRTRSLEAFEHQHVPFEVLVERLNPARSLMHHPLIQVLLAWQNFAGNTDPATGLALEDLQVTSLPLDTHSARMDIAFSLGERFTDTGQPAGLTGAVEYRTDIFDTTTINTLIHRLQRILVAITTDPEQPLSSVDLLDESEHTRLDEISNRAVLHAHTPPAMSVPALFAAQVARTPDATALSCGEDSWTYRQLDQTANRLAHLLTGRGVGPGCVVGILMERSAHAIATLTAVLETGAAYLPIDPEHPRARIEFMLTDTTPTAVITTTDLAERLDGIDVPIIDINDPALETQPSTPLPAPNPDNIAYFIYTSGTTGTPKGVAATHHNITQLLTNLSTGPTPASEQVWAQCHSLAFDVSVWEIWGALLHGGRLVVIPDSITRSPNDFHDTLAAEHVTVLTQTPTAAAMLAPQGLESITLILGGELCPAHIVDQWAPHTVINGYGPTETTMCVTLTTPLTPGSGAPPIGAAVPEAALFVLDRRLQPVPISVTGELYVAGAGVGCGYWRRSALTASRFVACPYAPGERMYRTGDLVRWTHDGQLHYVARADEQVKIRGYRIECGEIRTALTQLDGIEQAAVITREDRPGDKRLIAYITGTANPTDIRTQLAEQLPTYMIPSAIMTLDALPLTVNGKLDTRALPAPEYTTNHYRAPTTPTEEILTTIYAHTLGLDRVGIDDSFFDLGGDSISSMQVVARARAAGLVFRPRDIFVEQTVARLAAVAEGVGSAGGPVDEGLGPVVATPIMRWLHSVHGPIEQFNLMALLQAPAGVTEADVVVMVQALLDRHAMLRLRVDDDVDGWSLQVPEAGSVDASACLHSVDELSDEELTKAQSRLNPAAGVMLSALWVAPTRQLALVVNHLAVDVVSWRIVLDDLNTAWAQHRAGQQVALPTAGTSFARWASLLAEHARRPEVVGHAAVWRKVTAIPAALPTVQPEDTFATAEHMEVSLDVDTTRTILGEVPAALHAGVHEILLIAFALAWTEFLGNGGTPIGIDVEGHGREEELAPDVDLSRTVGWFTTKYPVSLAVGGLPWPQVTAGDTALGATIHDAQEQLRAVPNPVTYGVLRYLNADVDLTGSDPPIGFNYLGRLGVPVLDASADDDVWRIGYWGSLFTDNGNADHAMPLAHTAAVNAVTVDSDSGPHLHAQWTWASSKLDRAAMTRLSRLWFEALGGICAYARQGGTTMTPSDTATAQHCQQDIDAGSVDTVPAACPVGNLPDHADAPESEKPRKERLSYANYLHLDELLGAVQPLFANGDRCAYSDERYFLIVHQTSELWVSQILVDLELALESARRAEFDRAIDRMKRANAVLELMMSTESALQHLAVDAFQQFRPRLQGVSAAQSTQLATMLAGVRHAPVTALREIVDDRRDGDNRDRRQRLYLGAQLDVFIAGLTRWRLNHLDVVRRFIGDRRGTGGTVGLGFLIDRLSEGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H236</accession>
    <name>A0A231H236_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease</fullName>
            <ecNumber evidence="3">3.1.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42914">
        <property type="protein sequence ID" value="OXR42914"/>
        <property type="gene ID" value="B7C42_04800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="34165" checksum="02168364F5EEDA30" modified="2017-10-25" version="1">MRTGSVCAMLTSSASDRPLLLLDGASLWFRAFYAIPEKITAPDGRPVNALRGFTDMVAALITRHNPGRLVVCLDLDWRPAFRVELVPSYKAHRLDTTADAQPGAEEVPDTLTPQVDMIAEVLAAAGIATAGAAGLEADDVIGTLAACERDNEVIVVSGDRDLLQVVRADAPPVRVFYVGRGLARAELWGPAEVAAKYGVPQENAGPAYADMATLRGDASDGLPGVAGIGDKSAATLISRYGSLEALVAAVADPASDLARGVRAKLAAAEDYLKAAAPVVRVVRDAEVELSGPDLLPAEPADPDGLHALATAYNAESPVKRLTAALAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2B2</accession>
    <name>A0A231H2B2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42982">
        <property type="protein sequence ID" value="OXR42982"/>
        <property type="gene ID" value="B7C42_04868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="17563" checksum="04E690E3AB1D928E" modified="2017-10-25" version="1">MTPSDLFFQLGAEHRRQVHLSLCEDALSTWDDYVRGEPRELRYRDSVVGMRHKVEVELPADALRSARAGVDLAGVRDRYLEPICAMQDDDLVFPDPVEFAYYAIYNCFRKYARGDDIEDWLIVNQALSAHDIDEAAPRLTRTIDDVVRSRSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2F7</accession>
    <name>A0A231H2F7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_04912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042688.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43026">
        <property type="protein sequence ID" value="OXR43026"/>
        <property type="gene ID" value="B7C42_04912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="25105" checksum="E80D14A92709050B" modified="2017-10-25" version="1">MPQDGVVTTHNGAARRGRPPQTPAQADEVRSRIVAATAAVFTESGSRGLSVARIIEQAGISRPTFYRYFANATAPLDVVLTQSNEGLVGGIRRALEESEEPVALGIGIIDAYLDWARGHGPMLRPVFAELHDPASPVSAYREQAFDDIRALVREKFAVLGRQLPAPLDLDTALQVCAFVVYQVSLATAPGADPDPEAVAEARLTMIRTVLVTLGRREDVELALTIPGIFLPVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2I9</accession>
    <name>A0A231H2I9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Magnesium and cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">corC_2</name>
        <name evidence="11" type="ORF">B7C42_04952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43066">
        <property type="protein sequence ID" value="OXR43066"/>
        <property type="gene ID" value="B7C42_04952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="289"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="460" mass="49389" checksum="A099DD17B9EE84AB" modified="2017-10-25" version="1">MSVVLTIVSLLGFIALTAGTAIFVAAEFSLTALERSTVEAHAREGDRRARQVRHAHRTLSFQLSGSQLGITITTLVTGYIAEPVLARLIEPICTALGAGPGTAQGISLVIALVLATSLSMTYGELVPKNIAIAKPLTTARWTAGPMIVFTTVFSWLIKLLNGAANWAVRRLGIEPAEELRSARSPQELGSLVRTSAMRGSLDQRTALVVDRSLLFGERSAEDLMTPRVKIETLDQNDTITELIAAAGRTGLSRFPVIDGDLDNTLGIVHVKQAFLYPGGQRGTIALSSIARPVPIVPASLDGDTVLERVRADGMQLALVVDEYGGTAGLVTMEDIIEEILGDVRDEHDEEELDVRRTALGWNCSGLLRIDEVSRATGYDAPEGEYDTLGGLVLTTLGRIPVAGDEVLLPTPSSTNGHAMQPHTHGGWLARVERMDGRRIDRVLMQPVDADAVTTWELSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2M1</accession>
    <name>A0A231H2M1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator BlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">blaI_1</name>
        <name evidence="3" type="ORF">B7C42_04944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43058">
        <property type="protein sequence ID" value="OXR43058"/>
        <property type="gene ID" value="B7C42_04944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="14870" checksum="7F595AEF67E8F8EA" modified="2017-10-25" version="1">MDQLWSADEPQTVRQVHEALAARRELAYTTVMTVLQRLAKKNLVVQQRDDRAHRYAPVHTRDELVASLMVDALQQADEVGSRRAALVHFVEQVGKDEAAALRDALAKLEATETARNPSEDENTASDDNGVAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2P0</accession>
    <name>A0A231H2P0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777909.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43115">
        <property type="protein sequence ID" value="OXR43115"/>
        <property type="gene ID" value="B7C42_05001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="113" mass="12106" checksum="B88049F8C17EE5D2" modified="2017-10-25" version="1">MYDDLLTLAVESDRTLVLHGIPCGDCGKVMVLGLNTGVAACSTSWCVAAGISIQLWRILDAAILRALTVQSLEALVRNPASAVTIAQAQVHREADLAPEIGLTQDWRVPYGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2R2</accession>
    <name>A0A231H2R2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43139">
        <property type="protein sequence ID" value="OXR43139"/>
        <property type="gene ID" value="B7C42_04561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="15146" checksum="7A64A0C35E4A8F1D" modified="2017-10-25" version="1">MSTFKNADEVYTYIGGIFDIATKEQAFVEATTGTGLVVKLIQTDPDAVLVIDFPGQKVTTGDAARDMDATVQLRMSSDNSNRFWQGKLNFTLAMAQRKVKLDGKRSVALKLLPLTAGLFDVYKKLLVDNGREDLLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3B2</accession>
    <name>A0A231H3B2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crt_11</name>
        <name evidence="1" type="ORF">B7C42_04708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43286">
        <property type="protein sequence ID" value="OXR43286"/>
        <property type="gene ID" value="B7C42_04708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="28513" checksum="0F4E521F84017993" modified="2017-10-25" version="1">MTSAEVSKGPMLLTEQRGGVRILTLHRPAARNALTSHLIEALRRELAAADGDDRVDVVILTGADPAFCAGLDLRELGATGDNAARIAAADIPVGHPWRPLSKPVIGAINGAAITGGLELALACDFLIASERARFADTHARVGVLPGWGLTSRLPAAVGRGFARRMSLSGDFVDAATALRVGLVTEVVAHDQLLPTAMEVAVSVVGNDQNGVRTLLESYRRAEAHLLDPALAVEDATSRAWMAKFDPSAVAERRDAVIDRGRAQNRNAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3C4</accession>
    <name>A0A231H3C4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43349">
        <property type="protein sequence ID" value="OXR43349"/>
        <property type="gene ID" value="B7C42_04772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="10496" checksum="1A4013537C3AB1F9" modified="2017-10-25" version="1">MMSPERRELLSSDLDRGYKVASQVSDAANFIQTYADTADDLELAAFVRQFAVQLRTECMLRDRAELLAVKKPPMSWAEFSARHRTDTNERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3D3</accession>
    <name>A0A231H3D3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase PknK</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein kinase K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pknK_6</name>
        <name evidence="8" type="ORF">B7C42_04744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43322">
        <property type="protein sequence ID" value="OXR43322"/>
        <property type="gene ID" value="B7C42_04744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016236">
        <property type="entry name" value="Ser/Thr_kinase_PknK_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000574">
        <property type="entry name" value="Ser/Thr_PK_PknK_prd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1118" mass="121234" checksum="C7B719C4611647D4" modified="2017-10-25" version="1">MDNVTTQRDMSSGIVGELLAAGFGDPVEVGRGGSGVVYRCREYALDRYVAVKLLLSEVRGEERELFVREQRALGRLSVHPHIVQALHVDLTPTGRPYIVMPYFARGSLDQRMRQTGPLRWPEVVSIGVKMAGALAAAHAAGMVHRDVKPGNILLTDYGEPQLSDFGIVHVGEVTTGSTPLVHGTPAFTAPEILRGATATEAADIYGLGATMFCLLTGHAPFERRSEEPLEVQLTRIAEAALPDLREYGVPDAVCMVVESAMTREPADRPASVLELGERLRDVQRETGQPVDAVVVPPSDEDVAAGTGSGSPILPAVSAGSVTTPPPPSAATKFRPPTAARTAIERTRLREILDAGGRRRVILIHGPAGFGKTTLVAQWATALEADGVPVAWLTTDHDDDNVVWFLAHLVQAIRRVRPELARELGALLEERSSDATRAVLSALIDEIHDSDQAMVLVVDDWQLVRGENTLAAMNYLLEHGCHHLRVVLVTRGREGLALTKLLVQDELIEIDTTALRFDADEATAFLVGRNDLRLAAEDVAKVRRSTEGWAAGLQLAQLSLAGRDDPAAFIDNLTGRHHMIGEYLTENVLGSLDQPLLEFLMSTSITGATCADLAAALSGRSDSQELLELVADRNLFLQRMDEDDRWFRYHGLFAGHLVRRLEHQDPDRLRQLHSRASNWFAEHDMLVEAVDHALFAADPHRAVELVGARAIELIESFRTSTFLGLMAKLPTPLTESRPRLQLCLAWAALGQERHTQFHTALDRALAALETSDVDGRAARVLRAEAALLVGLEDYALDRLEIVPDTVTEHIDDLAAPVISVSAADLLAADALNRFEYPAGRRWHRSALRHGASSGALAVQHSHCIAGLAAWEQFDIAGAERHFAVTPTVPRGADLGTRIALMSGALLGDLRYRQGRLVEAERLLRAGATLERLGGMPDVLLASYGTGARLAIALGELTDAERLLSIGAQIAEDKSLPRLAARIVNERVRANLPIPDDIRSWLAALPPYRAQDTRIRAMTAELAQDSLIRLLLAERSPATIGEACDRSEILVREIGRQARPVALVQAQLLAACCQWAAGHHEKAKSLAAPVIARCIAQGVPRLVDDAGPGIHDIVGDLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3K9</accession>
    <name>A0A231H3K9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779331.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43421">
        <property type="protein sequence ID" value="OXR43421"/>
        <property type="gene ID" value="B7C42_04288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="153" mass="17668" checksum="7D4525B79F43B7C5" modified="2017-10-25" version="1">MTTVTESVDVHVPVTTAYNQWTQFESFPQFMQGVERVEQRDDTHTHWTVHVAGATREFDAKITEQHPDERVSWTSEAGPRHAGVITFHRLDEDHTRVTAQMDIDPDGFVENVADKLGILDRRVKGDLERFRDFIESRPQESGAWRGDVDRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3W7</accession>
    <name>A0A231H3W7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mmsB_2</name>
        <name evidence="4" type="ORF">B7C42_04319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43452">
        <property type="protein sequence ID" value="OXR43452"/>
        <property type="gene ID" value="B7C42_04319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="176"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="30169" checksum="66958BCE00D071AA" modified="2017-10-25" version="1">MSCADRDPDEEATVHIAVLGMGRMGRAVAGRLLDGGHRVTVWNRTEGKAAELISAGATEAGTVAAAVSGVDAAVTALADDAAVTSVAFGELQTTLDSGTPYIDCSTVSPALGAALADGFGDRFLALPIVGAPGAVTAGKATLLAGGPAHLRDQLGPLLGTLSERLRHYDSAAHALTAKVTTNFLLISGVAALAEAFTVGRSGGLGDDQLRELLAGAPVVAPALGNRFDAVLTASPDGWWTTVLGAKDAGLAVDIAAEAGAHLPLAEIVRKRYEDAARTNPDADIAAIAALYRDGGDSAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H489</accession>
    <name>A0A231H489_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bphD_1</name>
        <name evidence="2" type="ORF">B7C42_04525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43657">
        <property type="protein sequence ID" value="OXR43657"/>
        <property type="gene ID" value="B7C42_04525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018774">
        <property type="term" value="F:2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="28960" checksum="5CA9FF61B8B16971" modified="2017-10-25" version="1">MTTAQLTERVIDVWNESIRLRVKVAGSGPALVYLHPSAGLAWDGFLERLAQDYTVYAPELPGTSPSDPYAIHKVHDLWQLVLIYEEAIRKLDLDNPILVGQSFGGMLAAELAAAYPAHFGKLVLLDPIGLWRDDHPVANWITAPPEALPGLLFADPEGPAARAMLAPPEDPEQAIAAGAGMVWAVGCTGKFVWPIPDKGLVHRLHRISISTLIVWGEHDALISPIYADEFADRIADSSVVIIADAGHIPQVEQTEATYKAVDNFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H496</accession>
    <name>A0A231H496_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG3_4</name>
        <name evidence="1" type="ORF">B7C42_04480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43612">
        <property type="protein sequence ID" value="OXR43612"/>
        <property type="gene ID" value="B7C42_04480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="25115" checksum="E133F21155E1D8D8" modified="2017-10-25" version="1">MSGRLTGRVALISGGASGMGASHARAFVAEGARVMLGDIADDAGRALAAELGEQAGYVHLDVTESADWQAAVAATVERFGLLNVLVNNAGVLDGGPLGTYTEKQWQRVIDINLTGPFLGLSAARDALVAARPAAVINISSAAGIQGVGGMHAYTASKFGVRGLTKSAALELAPEGVRVNSVHPGGILTPMIGVTEEIAVDRGENVRARLGLPAEVSDLVVFLASTESSYCTGAEFVVDGGMTAGSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4K3</accession>
    <name>A0A231H4K3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4189 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43646">
        <property type="protein sequence ID" value="OXR43646"/>
        <property type="gene ID" value="B7C42_04514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025240">
        <property type="entry name" value="DUF4189"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13827">
        <property type="entry name" value="DUF4189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013348214" description="DUF4189 domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4189" evidence="2">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="14230" checksum="8F98096C6F2F4490" modified="2017-10-25" version="1">MSQMFSRRVRSAAVAAVAGAGFAVAGAAGSAQADGDLHGAIAYSDSSGVVAAATNFADAPSADAAARAHCGRGDCRVILDFSNGCGAVAQGADGRIAVGWGPTQIEAEKQARDFLGPSAPPFPDLGSASPRPATIALTSCTANAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4L6</accession>
    <name>A0A231H4L6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43795">
        <property type="protein sequence ID" value="OXR43795"/>
        <property type="gene ID" value="B7C42_04030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="78" mass="8470" checksum="950F5C47FBB51780" modified="2017-10-25" version="1">MRRLWILLDLVLVVACAVAAVPIWRHGVHRTWFAAVGDQPAFESTHYAGPWLALATVLVAAAGLAAIDLVVRCAVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H500</accession>
    <name>A0A231H500_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA polymerase III subunit beta</fullName>
            <ecNumber evidence="10">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaN_2</name>
        <name evidence="10" type="ORF">B7C42_04127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43888">
        <property type="protein sequence ID" value="OXR43888"/>
        <property type="gene ID" value="B7C42_04127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH merR-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="321" mass="34016" checksum="BAEF9350FF1E906D" modified="2017-10-25" version="1">MDPVSGYRYYADDQLERAVAIRGLREIGMPLDTIAAVLAAEGESAGQLIDEHVAGLEQHVRRARGRAAEIKAALGSGRGWAVATVSGPVFATAVEQILAATVHEPEHPVLSGVHVEASAEALTLTATDRYRLATRTLVPERPSSTEWAATVDGDDLRLAVPRIRRHHQVRLDAGPHSVRFRAGESAAGTCRILPGPFPDHRMLLGSIETARTRIVTPRDTLVRAMESLRARHIRLCVRAGAVTLANAGSGASEAVSATVTGPDAELTFDITTLYPAIGAAIGPEVMIDIAGPKQPVVIRSADDGDLTTLAMPVAPAHIEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5B8</accession>
    <name>A0A231H5B8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44143">
        <property type="protein sequence ID" value="OXR44143"/>
        <property type="gene ID" value="B7C42_03702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="40660" checksum="A94476055EAC7F9E" modified="2017-10-25" version="1">MSLHQLRHMAGHLLTPLLMCLGMGLAYLGAFHQPEPNHVQVAIVGDSPQVKVMAQTLKDRAGDALDVVTIADRADAVDRLQHRALAGAFVPAAQSPELLVAKANSDTTAMAVETVFGTVTAQQNLPLRTTDIAPTASGDPTGQGLFFVLVALSIGAYGSVAAISVAGAGTRMAVRALTAVATSFVVSVIGIALAGPVFHVVDHDYASIWAIGWLYAAGILFIGIGLHPFLKRWTTLAVMVLFVMLNFTTSGGIYRPELQNGFFGALHSFWNGAGFVEGARSLLYFDGNGGLGGRIASLALWFAAGVVLVVVGGAYERRRAAAHSTAHVPAHAATPGAVHDSARAVPAGAPAHAAATPAHAAAPAAAAPLSGNTAAADDFDEDSDAEEEIEQAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Z8</accession>
    <name>A0A231H5Z8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">argG</name>
        <name evidence="10" type="ORF">B7C42_03870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518242.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44309">
        <property type="protein sequence ID" value="OXR44309"/>
        <property type="gene ID" value="B7C42_03870"/>
    </dbReference>
    <dbReference type="GeneID" id="66721462"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="400" mass="43880" checksum="71D19EBC798E4623" modified="2017-10-25" version="1">MADRVVLAYSGGLDTSVAISWIGKETGAEVVAVAIDLGQGGEDMNVVRQRALDCGAVEAIVVDARDEFADEYCLPTVQANALYMGRYPLVSAISRPLIVKHLVEAAEYHGATTVAHGCTGKGNDQVRFEVGIGALAPDLNVIAPVRDYAWTREKAIAFAEENALPITVSKKSPFSIDQNLWGRAVETGFLEDLWNAPTKDVYDYTVDPTVNFEAPDELIVTFDKGVPIAIDGRPVSVLEAITELNKRAGRQGVGRLDMVEDRLVGIKSREIYEAPGAIALITAHQELEAVTVERELGRYKRQVEQRWGELVYDGLWFSPLKRALDAFVRDTQQHVSGEVRMVLHGGNVVVNGRRSEESLYDFNLATYDEGDSFDQSLAKGFVQIHGLSSKVAARRDLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6G7</accession>
    <name>A0A231H6G7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutY</name>
        <name evidence="15" type="ORF">B7C42_03237</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44448">
        <property type="protein sequence ID" value="OXR44448"/>
        <property type="gene ID" value="B7C42_03237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="14">
        <location>
            <begin position="59"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR44448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="34334" checksum="C1C12EF0CC188C98" modified="2017-10-25" version="1">MSSKTATGTTRDAVAEATRDPAAGVDSDVLIDWYEQSARDLPWRRPGVSAWQILMSEIMLQQTPVVRVEPIWREWVRRWPVPSAMAAASPGEVLRAWGKLGYPRRALRLHECARVLAAEYGDVVPDDVEVLLTLPGIGAYTARAVACFAYGQRVPVVDTNVRRVVARAVHGRAEAGNPRTRDLAETEALLPVRTDRAAVFSAALMELGATVCTARNPDCERCPLPRCTWVTSGRPASDVVRRTQKYDGTDRQARGRLLDVLRAATGPVERVALDLAWTRDPGQRDRALDSLLVDGLIEQTSDGLFALAGESGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6H3</accession>
    <name>A0A231H6H3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44390">
        <property type="protein sequence ID" value="OXR44390"/>
        <property type="gene ID" value="B7C42_03179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="7389" checksum="6F9A0AF4DF5A4BB0" modified="2017-10-25" version="1">MTQEIADSLKARVREKMLRQLNEDGAPDAEQDDPRQIAIENDLEAIDSVPDGDPLIEELAARYLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Q7</accession>
    <name>A0A231H6Q7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxocholest-4-en-26-oate--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.42" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775947.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44529">
        <property type="protein sequence ID" value="OXR44529"/>
        <property type="gene ID" value="B7C42_03318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="450"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="549" mass="59813" checksum="D3116C7239347B8C" modified="2017-10-25" version="1">MSYNIADLVEHTIDLVPDRVALADDVRSVTYAELEDRANRLAHYLQEQGVQPGDKVGIYSRNTIEAVEAMVAIFKARAVMINVNFRYVENELQYIFDNSDMVALIHERRYSDKVSAVRPNTPKLKTVIAVNDGTEAEVTLPADSVEYEAALAASHGERDFGDRSNDDIFMIYTGGTTGMPKGVMWRHEDWWRVLGGGINFVTGEAIEDEWQQAKAGAAGGQMVRYPIPPMIHGGSQSATFHGLFDGGKTIMLPEFSAHTVWQAIDRHGVNLIFITGDAMARPMLDALKEGNPETGEPYQHASLWAMASSAALFSPALKDEFIELLPNTVITDSIGSSETGFGGLSIAAKGATHTGGPRVKIDASTAVIDEAGNPVAPGSGQVGVLARTGNIPLGYYNDPVKTAATFKEFNGVRYSIPGDFARVEEDGTVTMLGRGSVSINSGGEKIYPEEVEGALKCHPEIFDALVIGVPDERWGQRVAAVVQCRGGNRPTLEELRPVLTKEISSYKLPRSLWFVDEIKRSPAGKPDYRWANEHARSRPADEESQASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6R8</accession>
    <name>A0A231H6R8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase fadE25</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_03281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44492">
        <property type="protein sequence ID" value="OXR44492"/>
        <property type="gene ID" value="B7C42_03281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="376" mass="41417" checksum="F95980BE90C69F72" modified="2017-10-25" version="1">MDLELDSAAAQFQLEVREFLRANVPAEPLPSMDTREGFEAHRAWEHTLADARLSVVSWQREYGGRDASLLEWVLFEEEYYAAGAPGRVSQNGIFLLAPTLFEHGTPEQLERILPRMARADDIWAQAWSEPEAGSDLAGIRSSAKRVEGGWVLNGQKTWSSRASFADWAFGLFRSDPEAERHKGLTYVMFPLSADGVTVRPIPQLDGEPGFAEIFLDNVFVPDRDVIGEPGAGWRVAMSTSSNERGLSLRSPGRFNATAARLIDLWRETADPADTAARNRVVDAWIGAEAYRLNTLGTVTRLAEGGKLGAESSINKVFWSELDIAMHETALDLLGAAAEHSSAWTDGYLFSLAGPIYAGTNEIQRNIVAERLLGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6T0</accession>
    <name>A0A231H6T0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3-dehydroadipyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">paaF_3</name>
        <name evidence="3" type="ORF">B7C42_03225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44436">
        <property type="protein sequence ID" value="OXR44436"/>
        <property type="gene ID" value="B7C42_03225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="28814" checksum="252FAAF3EBE9A05E" modified="2017-10-25" version="1">MSSELQVDVSAGVAVLTLNRPAQQNAMTPTMATELGTALRRCDTEDAIRAVVITGTPPAFCAGADLSARVGDVRGTIDPPPWQIRKPVIAAVNGHAVGIGLSLALQCDLRYMATDAVYGLNQVRRGAMADGYAHWTLPRLVGMANAADIMLTGRTFDGEEARQLGVANSSLPAGEVLPTALAVAHDLAAGSAPLPTALTKRLLWEGLGMSPEAVGRLESELHGFVGKSVDAAEGMAAFRDRRQPQWKGSISAEWPAGELSSPGERPGLDGTAEEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H715</accession>
    <name>A0A231H715_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 107B1</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44714">
        <property type="protein sequence ID" value="OXR44714"/>
        <property type="gene ID" value="B7C42_03508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="44641" checksum="9D7B79FB285AC0A5" modified="2017-10-25" version="1">MAEAEVSEQIELVEEDFHDDPHKYYERWRARGPVHHVRFTHERGIPCWVVVGHAEARAALADPRLHKNSAGTIDLFRRKGSAVLSNSDAQALSTHMLNTDPPEHTRLRKLVNNAFTPRRVAALRPRIEQIAAGLLDEVAAHDEVDLLHAFATPLPVTVICELLGVPFTDRDDFQLWTKILVGAAGDLTDRDRASADMGGYLTALLADKRARPGDDLLSGLATESDDGDRLTDPELVAMAFLLLVAGHETTVNLIGNGTFALLRDRPQFDALRADPEGIPAAVEEFLRLDGPVGWATVRYTEEPVDIGGTVIPAGELVYVALSAADRDPDRYHSPDALDIGRKPSGHVAFGHGIHFCVGAPLARMEAAVAFTALLDRFPKLALAPSFIPRWQPSLLMRGLTELPVRPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H771</accession>
    <name>A0A231H771_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44731">
        <property type="protein sequence ID" value="OXR44731"/>
        <property type="gene ID" value="B7C42_03525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="41"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="36531" checksum="44160C74EB769C8D" modified="2017-10-25" version="1">MSTDYRIIALEEHIVTTEVLTAWQKLEPRWRDLALTPSSQGDSGRRLADIGDERLAAMDAASIDVQVLSLTAPGVQNLEPADAIVLSCEVNDQLSDAVRTRPDRFQAFATLATPAPEAAAMELERAVTTLGLSGAMVFGRTRDRHLDAPEFQPLLETASALRAPLYLHPQSPPPGVREAYYAGLGDQLDAALATHGIGWHYDCGVELLRLILSGVFDRLPDLQVVVGHWGELMLFFLDRIDTNLTALAGLDRPISDYLRSNVFVTPSGILSQKYLRWAAETLGTDRILFAADYPFVPLSTRARTFLDAAASDPVVRAGIGSGNWDRIQARIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7U8</accession>
    <name>A0A231H7U8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44862">
        <property type="protein sequence ID" value="OXR44862"/>
        <property type="gene ID" value="B7C42_02816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="28909" checksum="786A110B0DB5ABCB" modified="2017-10-25" version="1">MRFAMNTVPPICWEPTEIDRCVVLDPDITLDAVTYRRFTDDLVKFVVEQPRAVIVCVDRMTIATETVLTAFTSAWLRTANWPGVPILLVAEDDALRRRLGRSAIRRFLAVQPSVGAAVAAAAEPPIRRRAAMTMTLSPVTGHRVRRLIDEVCAEWDIAGISEAAQIIATEFIDNADLHGHFTGVPDIDVRLEYREALLTIAIADPDPHEAVLREPEPGSAGRRLHGLHIVAELASAWGCAPRWPTGKVVWATLATARNRQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7X3</accession>
    <name>A0A231H7X3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxybenzoate 6-hydroxylase 1</fullName>
            <ecNumber evidence="2">1.14.13.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xlnD_2</name>
        <name evidence="2" type="ORF">B7C42_02780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.24" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44826">
        <property type="protein sequence ID" value="OXR44826"/>
        <property type="gene ID" value="B7C42_02780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018669">
        <property type="term" value="F:3-hydroxybenzoate 6-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="44912" checksum="281BE13380CD0600" modified="2017-10-25" version="1">MRIVIVGAGIGGLAAALSLHAAGFRDVAVYERADELRPLGVGINLLPHAVRELTELGLGERVATLGVAPRKLAYYNRFGQEIWCEPRGLEAGYNWPQLSVHRGELQRELLGAVHERLGAQTVRTGHRLVTADTDGRAHFATATGESTVDADLIIGADGIHSTLRHQHQPDEGPPVWNGLTLWRGTAKLPGFLDGRTMIMAGDAEQKFVAYPIRDAINVIAERRTVGFGGQNADWNRAVAPAQIVDLFRDWRFPWLDVPELLGAADEILEYPMVDRDPLDRWTYGRTTLLGDAAHPMYPNGSNGASQAILDARTLAFHLATARTPEEALAAYEQDRRPATTALVHSNRKQGPEQVMVLAHERAANGFAHIHDVISPKELSAIATGYKRAAGFDRDTLNARPSLTPPANEGNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Y4</accession>
    <name>A0A231H7Y4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44836">
        <property type="protein sequence ID" value="OXR44836"/>
        <property type="gene ID" value="B7C42_02790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="23827" checksum="0A5065392C176EB5" modified="2017-10-25" version="1">MSTLAVYPATPDETLVENARHSSVSHRMLLDLGSALLRVGPDPSATAGRLGRNDDRARSVRTDRLGSAILFRLRSRRPSTPFGQLSVGGAAVPVGGPNHGRCQRPGGQPAACGLVPGFGPIPAGTRNRRTPRLLNRLQSARQSLLTRATAVLGAGRATVPGLHTALQPLRLRGGPLRNFAIHDEPPGGCSWAAISTFYLRPVFGTRVDTRPAWCRPGRENADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H813</accession>
    <name>A0A231H813_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc-binding alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44866">
        <property type="protein sequence ID" value="OXR44866"/>
        <property type="gene ID" value="B7C42_02820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="118"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="34885" checksum="DBE529F3B581D656" modified="2017-10-25" version="1">MRGFAPGDRVVVCSTVSCGHCAYCRSGYTAQCDTANPNGPLAGTSFFGGPETTGPVDGLQAEYARIPYANNTLVKVPEGVSDDQAIMVSDVLPTGWFGARLAQVSEGDTVLVLGAGVVGQCAIASAFRQGAGRVLVVDGIADRLETARAQNAEPIDFHREDPVAVTRELTGGIGADRVIDAVGVDAQRPEQGPAADNLPVETDVFEEERRLAAPEGNTDSGQWLVGDAPSLAGRWAVQAVAKAGSVGVIGVYPPTFDRFPLGVVLNRNLTVQGGNCNHHRYVPGLLDKVGRGDLDPTRFITQHAEPQSMIDAYEAFDLRRTGWLKTVVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8E9</accession>
    <name>A0A231H8E9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal chaperone YciC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yciC_1</name>
        <name evidence="3" type="ORF">B7C42_03019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778763.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45062">
        <property type="protein sequence ID" value="OXR45062"/>
        <property type="gene ID" value="B7C42_03019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="230"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="38156" checksum="96F60493C84FCC5A" modified="2017-10-25" version="1">MDRRIPVLVVAGFLGAGKTTLLNHLLRRREARIGVVVNDFGAVNIDAMLVAGQVDAMVSLGNGCVCCAVDVSELDDMFARLAEPRHGIDVIVVEASGLAEPRNLIRMVIGSDNPRIRYGGLIEVVDAEHFDDSRARHPELAKHLRLADLIVLNKADRVSAARLDALRAEIEQIAAGAPVYATAHGRIDPPLLFDVPERGESTVARQLSFDELLDDHDHEVPGHHHLHDGYDSVSFTTATDLDPRRLVGFLEDPPPGLFRAKGATAFSVRGEGRKFLLHMVGRHVIFEPAAWSRGEARETRLVLIGSGLDPESATARLHATAHTGPEPLDEQALLPVWRYVPRDDTDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8L3</accession>
    <name>A0A231H8L3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45150">
        <property type="protein sequence ID" value="OXR45150"/>
        <property type="gene ID" value="B7C42_03107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="351" mass="37932" checksum="C206A7FCA10B5C4B" modified="2017-10-25" version="1">MKHRSRVSADTVLAWPPSADRSVAAALGVSAATPPPAPLDSLDSALLDLLAVDGRMTNRELAAATGASSATVGSRIRRLVADRVLIFTALFDWERAGFGWFVVATITVEGRSVREVANEVAALGECVGLATVLGSADLLGYFLVADRAELRRLSTERLGDVRGIGTVRMDLATDSTVTGLGRRFFLVRGEPLIRLPEPVIELDDLDTRIVAELLCDGRRSNRHIARKLDVSEGAVRTRLHRMTDSGLFCIEAMIEPTALGLVGALATVRIRADRNRVDRIAEAASRIAGVLLVASVVGDAEMVVAIGAADQFQLLAVIREGIRMLDGVRSVETHQMVEIVKFTPYFKRLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Y8</accession>
    <name>A0A231H8Y8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">abgB</name>
        <name evidence="3" type="ORF">B7C42_02415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45290">
        <property type="protein sequence ID" value="OXR45290"/>
        <property type="gene ID" value="B7C42_02415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="205"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="44743" checksum="02FEC009A038E9A9" modified="2017-10-25" version="1">MPRSGDERSWSRTDRSAHRAAASGCARAGDVDASVDPADPALLAAADAAVTAAESDLIALSHSLHAEPELAFAEHRSVAKTLAPLRECGFGIEMPVADLDTAFVATFGSGELVVGICAEYDALPEIGHACGHNIIAAAAVGAGLALAEVADRCGLTVKVFGTPAEESGGGKVLMLERGVFDGVAMALMVHPGPLDIVGARSLALADLSVSFHGREAHASAAPEYGRNAGDAATVAQVALGLLRQHLRPGQQLHGIVESGGVAPNIVPGHAELLYYLRADDSASLDDLLQRASACFEAGALATGCTHEIRALAPTYTELTPDSALLCAYREQIIGMGRMPLAPELEAARPLGSTDMGNVTNVIPGIHPVIGIEANGAVTHQREFAAACVTPSADLAVTDGARALARTAIQVAGDQLHRDRLLERSIQRQEEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9C3</accession>
    <name>A0A231H9C3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplD</name>
        <name evidence="7" type="ORF">B7C42_02679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776443.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45554">
        <property type="protein sequence ID" value="OXR45554"/>
        <property type="gene ID" value="B7C42_02679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="24368" checksum="98B5E48F444DEC6C" modified="2017-10-25" version="1">MSTDTVKSEKATNLTLPVKEPGGKTNGTVDLPAEIFDATANIALMHQVVVAQQAAARQGTHATKTRGEVRGGGKKPYRQKGTGRARQGSTRAPQFTGGGTVHGPQPRDYSQRLPKKMKAAALRGALSDRARNERIHVISELVAGQTPSTKAAKNFLAELSDRKKVLVVVGREDVTAWKSVANLQGVHPIAPDQLNTYDVLLSDDVVFSVEALNAFVHGPAESAQEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9V1</accession>
    <name>A0A231H9V1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45734">
        <property type="protein sequence ID" value="OXR45734"/>
        <property type="gene ID" value="B7C42_02026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="160"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="31190" checksum="0D5C45E7EDC75E0F" modified="2017-10-25" version="1">MSSDNGTERTIVAAVDGSGTALQAVRWAAAEAAVRRCGLRILLSSASAPRTGLSAMEIVGGREWLYWNGEGVLSEAAAMARHVADGVEVTTELTADPVIDTLVERSARTPMIVVGSHGRGAVRRALLGSVSSAVTRQARCPVAVVHRESLFTVGEDGRPVVVGVDEEGTAIGCAFEEAALRGVGLQAVRCCDDDVGGFVLDGELQQFRADETGALDRQLAPWHRKYPDVALESQIMFGGPAQILLERAGDAQLLVVGRHRWTGLAGTTMRSTRATVLHRAHCPTLVVPEHVDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA63</accession>
    <name>A0A231HA63_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">subB_1</name>
        <name evidence="1" type="ORF">B7C42_02125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517538.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45833">
        <property type="protein sequence ID" value="OXR45833"/>
        <property type="gene ID" value="B7C42_02125"/>
    </dbReference>
    <dbReference type="GeneID" id="66720164"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="6881" checksum="D741963E1FA04BDC" modified="2017-10-25" version="1">MKVRVDPERCQGHTLCAMVAPKSFVLSEIDGHSSAVSEDVPPDQEEQVREAAQSCPERAITIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAS7</accession>
    <name>A0A231HAS7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xthA</name>
        <name evidence="4" type="ORF">B7C42_01016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043337.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46053">
        <property type="protein sequence ID" value="OXR46053"/>
        <property type="gene ID" value="B7C42_01016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="31070" checksum="A190FEB4AD9C98D9" modified="2017-10-25" version="1">MRLATWNVNSIRSRVDRVVSWLDRADIDVLAIQETKCRDDQFPAERFEEAGYEIVHTGFSQWNGVAIASRVGIDDVEVTFPGQPGFDKDAEASLLSAPVVEARAIGATCGGVRVWSLYVPNGRTLTDPHYAYKLEWLAALRDSGHAWLRADPSAQIALCGDWNIAPTDDDVWSPEFFAHKTHTSAPERAAFEAVVAAGFTDVMRPFAPGPGVYTYWDYTQLRFPRKEGMRIDFVLASPALSARAVDAGVDREERKGKGASDHAPVVVEFSEQQPGPEVSSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAV3</accession>
    <name>A0A231HAV3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">accA1_1</name>
        <name evidence="12" type="ORF">B7C42_01038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13502"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46074">
        <property type="protein sequence ID" value="OXR46074"/>
        <property type="gene ID" value="B7C42_01038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="5"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="111"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="585"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR46074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="673" mass="71853" checksum="0C18D80BF9A3A893" modified="2017-10-25" version="1">MTVGPITNVLVANRGEIARRVFATCRRMGIATTAVYSDADANAPHVAEADAAIRLPGNTPGETYLRGDLIIEAAHAAGADAIHPGYGFLSENAEFARRVIDAGLAWVGPPVAAIEQMGSKVESKKMMDAAGVPVLAELDPDEVTEDLLPVLIKASAGGGGRGMRVVRSLAELPDQLEAARREAESAFGDPTVFCERYLETGRHIEVQVMADTHGRVWAVGERECSIQRRHQKVVEEAPSPLVERIAPMRERLFEAARLAAEAIGYEGAGTVEFLADEQGDFFFLEMNTRLQVEHPVTECTTGLDLVRLQLRVAQGYRLPPEPPPMRGHSIEVRLYAEDPAHDWQPQSGAVHRIEFAPGTAEFTVLTEPGLRLDSGVVDGSAVGVFYDPMLAKVISYADTREEAAHLLATALQQARIHGLVTNRDLLVRVLRHPAFLAGDTDTAFFATHGLEKLAAPLVSPGDEALSIVAAALADAAANRARARVGAALPSGWRNLPSQAQSKSYESRVSGTHEVRYRLTRSGLEVEGHEGLELIEATPDVVVLGVPGERGSVRRRFEVARYGDLVAVDSPLGPVAVRRLPRFSDPADQVAEGSLLAPMPGSVIRLGAEVGTAVEKGQPILWLEAMKMEHTIAAPAAGVLTELNVVAGQQVDVGAVLAVVHAEATAAPAEAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB86</accession>
    <name>A0A231HB86_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-CoA--L-malate CoA-transferase beta subunit</fullName>
            <ecNumber evidence="1">2.8.3.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smtB_3</name>
        <name evidence="1" type="ORF">B7C42_01069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.22" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46105">
        <property type="protein sequence ID" value="OXR46105"/>
        <property type="gene ID" value="B7C42_01069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="39212" checksum="6B888F9906AF01E6" modified="2017-10-25" version="1">MSTSSTTGQGPLAGIKVLELAGIGPGPHAALLLADLGADVVRVQRPGQLPGFMERPQWRGRTIVEANLKDPADIEKVLGLIDKADVLLEGFRPGVTERMGLGPDVTLERNPRLIYGRMTGWGQYGPLADRAGHDINYISLTGVLNAIGRKGERPVPPLNMVGDFGGGSMFLVMGVLSALVERSVSGKGQVIDAAMIDGALSLSHMIWGMRGMGLWSDERGTNLLDTGMAFYDTYETSDGKYMAVGCIEPQFYAEFLKGLEIDPEGLPMQIDPNGQDQLRKLFTEKFKTRTRDEWAAIFDGTDACCTPVLTFTEAVENGHITARESLVEIDGVVQHAPAPRFSRTQGGGVGVPPSAATAIDEVWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBE3</accession>
    <name>A0A231HBE3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore germination protein GerE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gerE</name>
        <name evidence="4" type="ORF">B7C42_01120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46155">
        <property type="protein sequence ID" value="OXR46155"/>
        <property type="gene ID" value="B7C42_01120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="765"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="742"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="836" mass="87787" checksum="15276012E179B3E8" modified="2017-10-25" version="1">MVGNLAVAFGAIPGAREILRELDSGSPDPLVYLIRGRCGTGKSTLLAAVRNRLRRSGIGCFDDVSATTTPPDTRAAVVVDDAHTLDQLQLEKLCAAVESDSRTIIVATRPQPHDTALRALADAVSRRGRVVELRPLGTADIAPFARELGMTVPRAVADHVHRNTGGIPGGVVAALTAACATRLEGGIEAVDQAVTSWARTLLDDTEPQLLEVLTVATTGAGLDPSELAEVLGTDEATAVGLVDRARAGALITDADLLLSPAIEPLRTLVGERRFVSIQRRLLTARLEAGLLRDHTALQLAESGVRDERLAEFLRAAADNAGGEASRYYTAAVASGYDAQRIAVPRATAAVFGGDDESALRLAEPVLARTDAAPAELAAAVRICASVQARRGLIGRAVQLYSWLGTTRTGADWATAAAVFHLAGAVGDAQAVSGSAAQWPPTETNARTGRFATALAQSITGESRSAATSAAAALIQLARTAAPEDRMLPCAPVALATLLCLSMGEPRRAADALRGTDPQDPQIQVLTAWTAMLGGDEQTAAKTVAAVDTTALPPRDRLLAHGVLVGLARRAGDHGVLLRAWEAAYPTFDEVDADLPALLPIGELWLAAIRLGEQERIARLVEAARDVLRSAGNPPAWANVFHWYEIQAAIAHERPDELMPPARLLKTAAQAGDPHAAILADAGRTWVLVLRGEVAEDRVTAAVRRLAAIGMVWDAARLASEAALSAGDPATATALLKLARTVRTGSRPSAAPERAPAAPRAATTPEPAAASVLSEREREVAELVLLGLTYREIGARLYISAKTVEHHVARIRRRIGAGSRSELLSMLRAMGHGSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBP1</accession>
    <name>A0A231HBP1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DegU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degU_2</name>
        <name evidence="5" type="ORF">B7C42_01234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46268">
        <property type="protein sequence ID" value="OXR46268"/>
        <property type="gene ID" value="B7C42_01234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="23234" checksum="78DCC36C1482A10C" modified="2017-10-25" version="1">MSGSEDAAAHDVSVMVVDDHPMWRDGVSRDLTEAGFRVVATADGVGTAGRRAAAVGPDVVLMDMQLPDGTGAQATAEVLRVSPRSRVLVLSASDERGDVLEAIKAGASGYLVKSASAAELIDAVRATAAGQAVFTPGLAGVVLGEFRRIAGAGAGTGAERPVLTERETEVLRLVAKGLSAKQIATRLSVSHRTVENHVQATLRKLQLGNRVELTRYAIEQGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBP4</accession>
    <name>A0A231HBP4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781540.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46239">
        <property type="protein sequence ID" value="OXR46239"/>
        <property type="gene ID" value="B7C42_01205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="17953" checksum="BC7E34CD4DDC31E3" modified="2017-10-25" version="1">MTCDLMLIAYDGSENAKRAVEYAGRFLSAPRAVVLTAWEPMVRQAARLSGLSGVMQPEWLPDEEIEDIAYVDAKQINAEGVRLAKLAGLNAEPRTAECTSTIWNAIVDVADELNVDIIVAGTRGSTGIRALLHSSVAEAVLKHCHRPILLVPPGKEPIPVSDLAGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBR2</accession>
    <name>A0A231HBR2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781574.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46275">
        <property type="protein sequence ID" value="OXR46275"/>
        <property type="gene ID" value="B7C42_01241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021414">
        <property type="entry name" value="DUF3054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11255">
        <property type="entry name" value="DUF3054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="14331" checksum="C4FD3174A5E56E42" modified="2017-10-25" version="1">MRKWLPLLIDIVLVIVFCAIGRRSHDEAVAAGLLRTVWPFGAGLLIGWVIALAIAGRGRPSAALARVDGSAVWPTGVVVWLSTLIGGMVLRVLSGQGTAVSFVIVAATVLAVFLLGWRAVWAVAARRIRVTGAPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBT3</accession>
    <name>A0A231HBT3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="2">1.1.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">garR_1</name>
        <name evidence="2" type="ORF">B7C42_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.60" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46279">
        <property type="protein sequence ID" value="OXR46279"/>
        <property type="gene ID" value="B7C42_01245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="30468" checksum="5A71234550D13275" modified="2017-10-25" version="1">MSERSSVTVIGLGPMGRAIVRTLLAAGTEVTVWNRSAGKAEAMAELGARRAESVADALDRNEVIVLSLTHYAAMYDVLGAAPERLRDKVIVNLSSDSPERTRAGADWVRSHGARFLSGGFMSAGDNITHPASYIFYSGPREVFDAHADLLRPLSAPEYLGADDGLAQLFYQALLTLFHPWLIGYNQALAVIERAGHDVDRFLPFAQRSAEAFPFFMAEYAAAAKAGGWGDEAAARMMVAGAAHVVETSEEAGVDATLSHTVRELWEKVAGAGVPMYRLLRDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC21</accession>
    <name>A0A231HC21_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">betI_2</name>
        <name evidence="6" type="ORF">B7C42_01364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46398">
        <property type="protein sequence ID" value="OXR46398"/>
        <property type="gene ID" value="B7C42_01364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="26370" checksum="6BE51D12FE5CB1E6" modified="2017-10-25" version="1">MAIPSASEPAPIGGRQARWQTHNDTRRGRIVEALIELLEESGGGEISMQQIAKRSGLAKSVVYRQFSGRDELDRRARSVIAEQFIDTVDAALDIWDGSIHRILHRTVAAVADWLTEHARLYDFARSGPAMGDPDDVDALSSIKATIAARTRLLVSSLAGVIGVVDEATADTMTFAIVSMTEATVGRWARDPDPMLSREQLISEVAGYAWSVLDGAARAHGLTLDPELPLIELVNALAEGVDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC29</accession>
    <name>A0A231HC29_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46306">
        <property type="protein sequence ID" value="OXR46306"/>
        <property type="gene ID" value="B7C42_01272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="54315" checksum="AA543C956941F66D" modified="2017-10-25" version="1">MDTAEQVTGPDHAPAAAGVRHATPGRRAYLKVTSQNREMNGPGFTPTQLAARASYLLRGNDLGTMTSAAPKLYPHMWSWDAAFVAVGLAPLSVERAVVELDTLLSAQWRNGMIPHIVFANGVDGYFPGPSRWECRRLATNAPAGPDTSGITQPPVHAIAVQRILDHSRRHGRTTRAVAAEFLDRRWVDLMRWHRWLAHARDPKQHGRITLYHGWESGMDNSPRWDRAYANVVVGDLPPYRRADIDVVDPAQRPSDREYDRYLWLVEQMRRCGYDDFQLASTMSFAVEDVFVTAVFALACEVLAGIGEDYRMPHADVRELYEWADYFRAGVIATADPRSGAARDFDLRADEWIGTETLAMFAPLLCGGLPRATERSLLRLFEGPRFCGHPDLRYALPPSTSPVSKDFRPREYWRGPVWPVMSWLFSWVFARRGWAERSFMLRAEGLRQAGDGSFAEYYDPFTGDPLGSMQQSWTAAAVLDWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCQ1</accession>
    <name>A0A231HCQ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46691">
        <property type="protein sequence ID" value="OXR46691"/>
        <property type="gene ID" value="B7C42_01666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013348195" evidence="2">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="17260" checksum="9447003C6F4D76EF" modified="2017-10-25" version="1">MRRSTIAAAVTLATLTLAGCGSSDTPSSSSPSPTPAATSARQAALIQPVPDTHKNKYVVGPFTVTLVQGIAQQPSGKTGSELLVENTSNDFTGYCNPEIQYTQGNEVVATSNPSTGSLAPGQKQTVWVDIVPDRDVSGQYVDAQLVSVWFGTDRGEPGTRLQLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDG3</accession>
    <name>A0A231HDG3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hoxN_1</name>
        <name evidence="9" type="ORF">B7C42_01840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041816.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46862">
        <property type="protein sequence ID" value="OXR46862"/>
        <property type="gene ID" value="B7C42_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00802">
        <property type="entry name" value="nico"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="368" mass="39787" checksum="2CD7DDD9D6B9F5F8" modified="2017-10-25" version="1">MSSRRRLLRDVLRDWSRRDWLEAGVLLGVVALMHLIGFGLLFGAIAPHGYRIGTEVFGIGLGITAYTFGLRHAFDADHIAAIDNTTRKLMSDGKRPKSVGFWFAMGHSTIVFVLAALVVAGAHVVGTLVDEDSPTRRTLGTISTVASGSFLYLIGLLNVVALIGIWRVFRRLRDSGHYDRAELEAALDSRGFLARLLAPVMRMVGRPVHVYPVGVLFGLGFDTATEVALLALAGSGAAAGLPWYAIVVLPLLFAAGMSVMDTIDGLFMNVAYDWAFSDPVRKIFYNLAITGLSIAVALFIGSIELIKVLHDDTGFGGPVAEWISGIDLNNAGFAIVGLFVVAWVVAVAYWRLAKVDERWTPAPTEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI3</accession>
    <name>A0A231HDI3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Nudix hydrolase NudL</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nudL_1</name>
        <name evidence="6" type="ORF">B7C42_01861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. PCD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46882">
        <property type="protein sequence ID" value="OXR46882"/>
        <property type="gene ID" value="B7C42_01861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009132">
        <property type="term" value="P:nucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000059">
        <property type="entry name" value="NUDIX_hydrolase_NudL_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01293">
        <property type="entry name" value="NUDIX_COA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="59"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="27057" checksum="AEAB4952075E8D60" modified="2017-10-25" version="1">MPDRSDMNDNSTAEHRPHLLATDIPDWLRGVAEHEPADPTGVNQVLNRTAGKLVSAALRPREAAVLVLFGGSPDADPGARGGLPADADVLLTQRAATLRQHRGQVAFPGGGVEPGDDGPVGTALREAREETGLDPVGVEPFAVLPKIFVPPSRFDVTPVVAYWRTPGEVGVVSETEAARVVRVPLADLIDPANRFVVRHPLGYMGPAFAVDGMLVWGFTAGVLAGLLAVSGWERDWDHHDVRDLQASLAAVGMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDV2</accession>
    <name>A0A231HDV2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46925">
        <property type="protein sequence ID" value="OXR46925"/>
        <property type="gene ID" value="B7C42_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="13975" checksum="25C23F68A4F10AFE" modified="2017-10-25" version="1">MADFWSTRADDVAAYWVRWHPLVGNLERAVAALESGRSSWTTPLGVVRPALGDDAASVTADRLRTVIGYLIVAGHWVPGIPDIWIVADADNDACSSRASVPPPEGGMSGQSIETLRPGPADRPERFDPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE02</accession>
    <name>A0A231HE02_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47006">
        <property type="protein sequence ID" value="OXR47006"/>
        <property type="gene ID" value="B7C42_00123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="99" mass="10972" checksum="6130D8FD011FFC8E" modified="2017-10-25" version="1">MDWKHDQIARRELQRGDTPVIVRIGRPYQEGISWFCPFRIEGLQNEPFEQAAGGADSVQALYLGLKMIDTVLNSFNADGSITWDGEADLGFPRTSVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE58</accession>
    <name>A0A231HE58_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylserine dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psdht</name>
        <name evidence="4" type="ORF">B7C42_00178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776978.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47058">
        <property type="protein sequence ID" value="OXR47058"/>
        <property type="gene ID" value="B7C42_00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="27"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="316" mass="32749" checksum="3284F00D041F57DA" modified="2017-10-25" version="1">MTEAPARIPRLFRADIRAARERLGNDVRVTPVFHTEVAGPEGPVKVTLKLEHLQHGGTFKVRGSLNALLQSADDGRPVVIASGGNAGIAAALACALRGRPCTVVVPETAPHTKVAAMWGYGAEVLWHGTTYAESKRHADAVTAERNALQLHAYDLPAVVAGAGVVGLEIERQVRGRPPVLMAVGGGGLMAGIAIALGPRSRVIGVEPKGAPTLYAALSAGRPVDVPVDSIAADALGATRIGDIALDTAIRYGVGSLLVGDDAIAMAREYLWREFRLVVEPAGAVALAAVQSGAYVPEPGERPVIVLCGANTDVSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE98</accession>
    <name>A0A231HE98_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent monooxygenase, oxygenase subunit HsaA</fullName>
            <ecNumber evidence="3">1.14.14.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hsaA_1</name>
        <name evidence="3" type="ORF">B7C42_00336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.12" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777073.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47214">
        <property type="protein sequence ID" value="OXR47214"/>
        <property type="gene ID" value="B7C42_00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036383">
        <property type="term" value="F:3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="234"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="387" mass="42640" checksum="790A7B7EBDCB4D56" modified="2017-10-25" version="1">MANKVLDRVRDLLPAIGERAVTAEQERRVPAETIRELTEAGVFRMLQPSRFGGAEESPVAFYEVIRTIATVCPSTAWVSSVLGAHPWQLALFDPRAQQDVWGEDPDTLVSSSYAPTGKLTPVDGGFEMSGRWSFSSGCDHADWAFLGAVVPNDKGGADYLTVLVPRADYRIEDVWHVSGLSGTGSNDIIVEKAFIPAYRTYSAADQSALVGPGQEVNTAALYRISFASVFSNTITAPIIGAAQGAYESHLRRQRERVRLSYGGQKVADDPFAQVRIARAASEIDAAILQQERNISEQLRYAEAGEEIPYELRLRTRRDQVRGTERAIYAIDLLFENSGGHSIRKPNVIERNWRDAHAGNAHVINDVERALAMYGQGEMGVEVTERMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HED5</accession>
    <name>A0A231HED5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fkbP_1</name>
        <name evidence="8" type="ORF">B7C42_00258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777018.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47136">
        <property type="protein sequence ID" value="OXR47136"/>
        <property type="gene ID" value="B7C42_00258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011226227" description="Peptidyl-prolyl cis-trans isomerase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="106"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="19507" checksum="D94558C7FCB46F07" modified="2017-10-25" version="1">MQTLARIIGTAAVAVAAVALTACGGNDDNGSATTSSTVAGAQPRAGTSAAAAPTASHGRECTADDIGVTGGFGQAPTITIPDNCDPPKQLVTKDLVEGTGPAAATGQPVEMNYTLVTWSDKKKLDSSFDRGQTFPLTLGTGEVIQGWDQGLIGIKQGGRRLLIIPPDLGYGQGGQGVKPNETLVFVTDAVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEF0</accession>
    <name>A0A231HEF0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47353">
        <property type="protein sequence ID" value="OXR47353"/>
        <property type="gene ID" value="B7C42_00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016888">
        <property type="entry name" value="UCP028498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10012">
        <property type="entry name" value="DUF2255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="14127" checksum="BE39981802C47FA4" modified="2017-10-25" version="1">MAWTAAQLDRIGSSEELEITSYYENGALRDWTTIWVVRVDNDLYIRSAYGQSGGWYRHAMHTRGARVRAHGVETDVTLHPVTESYINDRVRKAYESKYRDQPIALEPMLAPAAENTTLRVDPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEM5</accession>
    <name>A0A231HEM5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate/thiosulfate import ATP-binding protein CysA</fullName>
            <ecNumber evidence="7">3.6.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysA_1</name>
        <name evidence="7" type="ORF">B7C42_00380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.25" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777104.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47258">
        <property type="protein sequence ID" value="OXR47258"/>
        <property type="gene ID" value="B7C42_00380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102025">
        <property type="term" value="F:ABC-type thiosulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03296">
        <property type="entry name" value="ABC_CysA_sulfate_importer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005666">
        <property type="entry name" value="Sulph_transpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024765">
        <property type="entry name" value="TOBE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12857">
        <property type="entry name" value="TOBE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00968">
        <property type="entry name" value="3a0106s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="331" mass="36357" checksum="38508EC997560AD3" modified="2017-10-25" version="1">MITVTDANKRYGSFAALDNVSLDIPSGELTALLGPSGSGKSTLLRSIAGLESLDSGIVTIADRDVTRVSPQKRDIGFVFQHYAAFKHMTVRDNVAFGLKIRKRPKNEIRKRVDELLGIVGLDGFQHRYPAQLSGGQRQRMALARALAVDPQVLLLDEPFGALDAKVRHDLRTWLRRLHEEVHVTTVLVTHDQEEALDVADRIAVMNAGRIEQVGTPEDVYDRPANEFVMSFLGAVAKLNGHLVRPHDIRIGRDPGMALAEHEGTAESAGITRARVERVVRLGFEVRLELRNAATGDLFTAQVTRGDAEALRLAEGETVFARATRIPELPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HER7</accession>
    <name>A0A231HER7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Meth_synt_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47364">
        <property type="protein sequence ID" value="OXR47364"/>
        <property type="gene ID" value="B7C42_00487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="356" mass="36970" checksum="03F096CA6FC889E3" modified="2017-10-25" version="1">MMSENRSDAAPVLRGGIATGVGSWPGADPREAAATIVGELPDLAHLPELPGRGAGSDIVGRASALLIDMQFDTTTRGYRLSARPGATARRAHDLLRTDLDALEEAWETAGLTGAGRTLKVQSVGPLTLAAQVELANGHRVLTDSGAVRDLSESLAEGLRNHAAEVGKRLGADVVVQLDEPSLAAVLEGSLRGASVLNTVRAVPEPEALHILDTVVTAQPGPVLIHSCADTPPLSFLRASAAAAIGFDMAAVATGNLDAVGELLDAGKYLALGLVPTTAPATPPTWRQLAEPGVRLVDRLGFPRRTLTDRVLVAPACGLASAPLTWARRALDLSSDVARAYADDPDSLTFDQRHGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HET1</accession>
    <name>A0A231HET1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">kdpB</name>
        <name evidence="15" type="ORF">B7C42_00616</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47491">
        <property type="protein sequence ID" value="OXR47491"/>
        <property type="gene ID" value="B7C42_00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="406"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR47491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="717" mass="75138" checksum="1D182130F858B647" modified="2017-10-25" version="1">MTTPTNDSVTTPRAVEPSSRRGGHGIFDPAMLARSLPEALRKLDPRTLWRNPVMLIVELGALWSTILAVAHPTVFAWAIVIWLWLTVIFANLAEAVAEGRGKAQADTLRKAKTDTVARRLVDWHPGAEAALEETVPAPELRRGHYVVVEAGQVVPGDGDVVEGIASVDESAITGESAPVIRESGGDRSAVTGGTTVLSDRIVVEITQEPGGSFIDKMIALVEGASRQKTPNEIALNILLAALTIIFVFAVVTLQPPAIFAKANNPGVGDSAALTAHGVTGIVLVSLLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVNTLLLDKTGTITLGNRQAAGFVAMPGVTEDEMADAAQLSSLADETPEGRSIVVFAKTAYGKRERTPGELAGATWVEFSAQTRMSGVDLRDGHRLRKGAASAVTEWVRAHGGSVPEEVGRTVDGISASGGTPLVVAELLDGRARLLGVVHLKDVVKQGMRERFDEMRRMGIRTVMITGDNPLTAAAIADEAGVDDFLAEATPEDKLALIKSEQAGGRLVAMTGDGTNDAPALAQADVGVAMNTGTSAAKEAGNMVDLDSDPTKLIEIVEIGKQLLITRGALTTFSIANDIAKYFAIIPALFVALFPGLDVLNVMRLHSPQSAILSAVIFNAIVIVALIPLALRGVGYRPSSASTLLSRNLAVYGAGGIVAPFIGIKLIDLVVRFLPGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF13</accession>
    <name>A0A231HF13_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47398">
        <property type="protein sequence ID" value="OXR47398"/>
        <property type="gene ID" value="B7C42_00521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15538" checksum="FB6277CE919CADB8" modified="2017-10-25" version="1">MEPPSYRAIERLIADYALLVDQGDFASVGALFATGAFGGSAGMIEGSAAVEKMLSATVIRYDDGTPRTKHLVTNLVIEVDAAEDTAAARSYFTVLQATPDLPLQPIVSGRYADRFHRPDGRWAFAERAVTMDLIGDVSHHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF22</accession>
    <name>A0A231HF22_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47408">
        <property type="protein sequence ID" value="OXR47408"/>
        <property type="gene ID" value="B7C42_00531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="473" mass="50722" checksum="8ADC5DD5C5C19D2C" modified="2017-10-25" version="1">MVLDEVWRGIDGVEALSGAQGGPLRRTVKLILDPLVIRPVQYPACAGPMLTADGATLLAARVHAAGDVLRATAAWFSLLKQVRRALRITDGNPQDLYFQRCFELATVSGAPDPVRDRPTATATLHDIHHLAAGRTTQALKDHLTDRSTTGELAALIDTAWLRRPQSAPAGADHTTALAALLDACATARADDAARELRALITERAGAHSGITLWHNTSGDSAQELGLTVHRLPVAPALGTGASTATLALPFDRTVYERVFTVLQASTERSDLPTIPELVTEEIARSCAPWALLDESLRVTAAAGVELALGLAPAAGTVSSPASEPAISGRSDRVPDPKRSAHQSLSSQTSISTRQGGTAAHRVINGRWRREAYVLQARRLAVHETSEPADPLSMIAAELRHPWRSYLRRLWVRLHGRDVRNASLSQASPDVTELWDLLDGVARSVILDHRTRVRKALTATSPAAVDDSLESRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF54</accession>
    <name>A0A231HF54_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779600.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47611">
        <property type="protein sequence ID" value="OXR47611"/>
        <property type="gene ID" value="B7C42_00736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16875" checksum="167792B426E29DEB" modified="2017-10-25" version="1">MMSTVALKRSWAADLDTATLYKLLKLRVEVFVVEQKCAYPELDGLDLLPETRHFWLDDEGEIICTLRLLEEHHNGVKSFRIGRLCTTPEARGHGYTTRVLQAAIAEAGSATVRLNAQTYLVDLYTKHGFKPDGEEYEEDGIAHIPMRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF96</accession>
    <name>A0A231HF96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47653">
        <property type="protein sequence ID" value="OXR47653"/>
        <property type="gene ID" value="B7C42_00778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601733" evidence="1">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="155" mass="16723" checksum="ED6FDCB0C5490550" modified="2017-10-25" version="1">MKIRAFVMAAAALVAPMVLSAPAPMAHASSPWGACGTRTDESKVVTTYGEWKLLCGNKNYGYRHIQDRHQAEWEGLADIEGRNWRDIADMAIAKAHDAPDWHGPQGSGKYCYTGQIYLVNHVTGAIVKTVQPTVIVAENGQVVTAFPGGACRGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFG1</accession>
    <name>A0A231HFG1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hflX</name>
        <name evidence="8" type="ORF">B7C42_00836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47711">
        <property type="protein sequence ID" value="OXR47711"/>
        <property type="gene ID" value="B7C42_00836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="295"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="532" mass="57118" checksum="D0657ABAD346E30D" modified="2017-10-25" version="1">MRKSQTYEFTPIEQLDSDTDYADQDYSIGDDDADTGVTDYDADETEGGGYSGNGWAAEPTVGELQLDERSALRRVAGLSTELTDITEVEYRQLRLERVVLVGVWTEGSAAQADASMAELAALAETAGSQVLDALIQRRDKPDPATYIGSGKADELRSVVLETGADTVICDGELTPAQLNALEKVVKVKVIDRTALILDIFAQHATSREGKAQVSLAQMEYMLPRLRGWGESMSRQAGGRAGGAGGGVGTRGPGETKIETDRRRIRERMAKLRREIKEMKTARDTKRSRRTSSGIPAVAIVGYTNAGKSSLMNALTGAGILVQDALFATLDPTTRRAALDDGREVVFTDTVGFVRHLPTQLVEAFRSTLEEVTGADLLLHVVDGSDALPDQQIKAVREVITDVLREQGEGSGPPELLVVNKIDALDATQLAHLRAQLPGAVFVSARTGRGIDQLRERLAEILGGLDVEVSVLLPYTRGDLLARIHSDGRIISSSHEEGGTRVRARVPRALAPTLSQYAHAGTIGSAEAAGPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFK7</accession>
    <name>A0A231HFK7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxynitrite isomerase</fullName>
            <ecNumber evidence="1">5.99.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ferric nitrobindin</fullName>
            <shortName evidence="1">Nb(III)</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="1">Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.99.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47598">
        <property type="protein sequence ID" value="OXR47598"/>
        <property type="gene ID" value="B7C42_00723"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062213">
        <property type="term" value="F:peroxynitrite isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="2">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="37"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="20442" checksum="5E468FF8B4F2EA89" modified="2017-10-25" version="1">MVLPPSAARGTKLCAVLEPQPAVAPHPDIAHLAPLLGTWRGSGHGEYPTIEPFDYHEEIRFGHVGRPFLTYRQRTRHAADGRSLHAETGYLRSTGADRVELILAHPTGVTEICEGRIAVAEDGLRLELDSTHIGTSSTAKTVTALGRSIHLSGDTIDYKLRMAAVGQPKQHHLSASLHRAEQNEKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFM2</accession>
    <name>A0A231HFM2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor Bm3R1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bm3R1_1</name>
        <name evidence="5" type="ORF">B7C42_00632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47507">
        <property type="protein sequence ID" value="OXR47507"/>
        <property type="gene ID" value="B7C42_00632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="21196" checksum="EC573EB1B48BA159" modified="2017-10-25" version="1">MVPEPIRPDSLRADARSNRDHILLAALDVFAERGTDVPMKLIADRAGVGVGTLYRRFPDRDALVVATAQAHLDRLARMAASAGAEEATAWDGLRRFLRECALLRLGALAAAIEPAVHAMVRTDPRVGAVRAGVLDRIDELIRRAQRDGDLRTDIGLTELGLLMTVQVYAQPGESYPAAVDRVLAIVFDGLRPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFN9</accession>
    <name>A0A231HFN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47536">
        <property type="protein sequence ID" value="OXR47536"/>
        <property type="gene ID" value="B7C42_00661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="61" mass="6243" checksum="D80D4711C225846B" modified="2017-10-25" version="1">MLAISCIVLSAVIALGAFGRWRLVGAAMREGRPLPNTVMVPILAIGIAVIAMLAGIGLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFT6</accession>
    <name>A0A231HFT6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">rlmN</name>
        <name evidence="14" type="ORF">B7C42_00670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779781.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47545">
        <property type="protein sequence ID" value="OXR47545"/>
        <property type="gene ID" value="B7C42_00670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="114"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="240"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR47545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="40105" checksum="D36AB8C1A7F21961" modified="2017-10-25" version="1">MTTSLPLVFDAPRRGMPPRHLADLDSAQRRQAVEELGLPKFRADQIARQYYGRLQADPRQMTDLPEPMREKIAEALFPPLLSEVRQVVCDAGTTRKTLWRAGDGTLLESVLMRYPDRNTLCISSQAGCGMACPFCATGQGGLNRNLSTAEIVDQVRAAAAALRDGEVAGGAGRLSNIVFMGMGEPLANYKRVVAAVRRITSPAPDGLGISQRNVVVSTVGLAPAIRKLADEGLSVTLAVSLHTPDDELRDTLVPVNNRWSVAEVLDAARYYADKTGRRVSVEYALIRDINDQPWRADMLGQKLHKALGARVHVNLIPLNPTPGSKWDASPKPVEREFVRRVEAQGVPCTVRDTRGQEIAAACGQLAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFT8</accession>
    <name>A0A231HFT8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycinamicin IV hydroxylase/epoxidase</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mycG_1</name>
        <name evidence="4" type="ORF">B7C42_00692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779765.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47567">
        <property type="protein sequence ID" value="OXR47567"/>
        <property type="gene ID" value="B7C42_00692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="45304" checksum="8BE248A743E1A5CE" modified="2017-10-25" version="1">MSNSIDETLDYYPFPLGPLGEPPERFSELRAQCPVTKVRLPSGDTAWAVTGYDEVVAAMSDSRLSRAALREPGAPRVINGPDFADNPFNLLSQDGADHRRLRRLISPAFTPKRAEQIRPRIQEIADELVDELEAGPRPADLHHDFAALLPIWVITDLLGASRERRADIQRWTDHLVSITAHTADERLTAREESAAYVVSLLAQRREALGEDLLSDLITARDDGDRLSEQELVWLTINLLVAGHDTTVSALSRAAFMVLRHPDQWRLLVDQVDDRQVVRHAVEELLRYAPPSEIGFIRVATEELEIGDVVVRQGEGVIPIMHAAGRDTRHVTEPDRLDLTREDVKHVAFGHGSHFCPGAGLARLELEIGLATLARRLPNLRLAVAPENIDWSSGLLTLRPNTFPVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGD5</accession>
    <name>A0A231HGD5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47786">
        <property type="protein sequence ID" value="OXR47786"/>
        <property type="gene ID" value="B7C42_00911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13307" checksum="6684D10880DF57AF" modified="2017-10-25" version="1">MSERADVSPNLTEQGRGPAIARVATELIAWVAAPWALASWSVAAAVIAVTVLIGVPSIFATRGDKKQVLVAVPGWATIAMMLVLVAAAVLGAWFAWPAWVAVLVTVLAVVTVGTELPRWRWLARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSZ3</accession>
    <name>A0A231GSZ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000074">
        <property type="protein sequence ID" value="OXR39743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39743">
        <property type="protein sequence ID" value="OXR39743"/>
        <property type="gene ID" value="B7C42_08182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8753" checksum="C7F64880D1B9CD29" modified="2017-10-25" version="1">MLDGVTDDVLLDVPAGLRQWLCGADSRAEIDGHGVHITPTWWARNLVTYGFDNPVADSSVTRGSCSRWPMPRSRQPMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT04</accession>
    <name>A0A231GT04_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000072">
        <property type="protein sequence ID" value="OXR39753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909767.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39753">
        <property type="protein sequence ID" value="OXR39753"/>
        <property type="gene ID" value="B7C42_08175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="12709" checksum="BD4E81C8E37F450D" modified="2017-10-25" version="1">MTSGQTLLRVVMPTAATAVLATGLAVAVNYATGANHSVWAWVAVVALTVGVFAVSLWVQHAPSTDRELAIGVDLRNVKTERGLRVKGVRSTGTGIRAARVRSGGDMSFEDIRTGVDNPTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT72</accession>
    <name>A0A231GT72_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043521.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39816">
        <property type="protein sequence ID" value="OXR39816"/>
        <property type="gene ID" value="B7C42_08104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007499">
        <property type="entry name" value="ERF_bacteria_virus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04404">
        <property type="entry name" value="ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="23897" checksum="5C764C57031CC905" modified="2017-10-25" version="1">MADAKPTVFEAFSAVQGEIQAIEKNEHNSQQGFNFRGIDAVMNAVGPVLREHGVFIIPRGLSIQFERYETKSKTAMRNATVEMEYTVFGPAGDSFTGSAYGEAADSGDKAVSKAQSVAFRTFLLQGLTIPTRQDDPDASSHDRVTFSQEAQDARDDLTELCAQLGIHPRKAMRDFADANGGLDIRQATDPGPIRGLANRYRAENPAPDFAENQGAAGDEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT94</accession>
    <name>A0A231GT94_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000063">
        <property type="protein sequence ID" value="OXR39798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39798">
        <property type="protein sequence ID" value="OXR39798"/>
        <property type="gene ID" value="B7C42_08127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="37" mass="4349" checksum="B972FF0A3409307E" modified="2017-10-25" version="1">MPSSLLILAWGRRVSQTKVRSTVFQALVHFRWYDVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTC3</accession>
    <name>A0A231GTC3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000055">
        <property type="protein sequence ID" value="OXR39866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39866">
        <property type="protein sequence ID" value="OXR39866"/>
        <property type="gene ID" value="B7C42_08063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="56" mass="6590" checksum="7D674CC25963FCF1" modified="2017-10-25" version="1">MITLFIGCVILSIIIYITIVCWPQRIPPERRVTEIRHRIERENTDPAGPHGDTYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTL9</accession>
    <name>A0A231GTL9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitinyl-CoA dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">caiD_12</name>
        <name evidence="2" type="ORF">B7C42_07956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.149" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39977">
        <property type="protein sequence ID" value="OXR39977"/>
        <property type="gene ID" value="B7C42_07956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="27511" checksum="045373A32BC96D8C" modified="2017-10-25" version="1">MEEVVRYEVDSGVAWLTIDRPHARNSLSKAVRHGLFEGVRRFNDDAGAKVLVLTGAGDKAFCAGGDLKEMSEEKLTIPPVDYVPQFGRNIDVVKPTIAAVNGAAFAGGFLLAQTCDLCIASTTATFAISEVKVGRGSPWAAPLPLMIPRRVAMEIVLTGAPMTAQRAYEIGFVNQLAEPDQLRERAQAFAQQIVANAPLSVLAGKQTMALTAQYPLREAFDRAETIWAPVYSSADAQEGMLSFTEKRAPRWQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU57</accession>
    <name>A0A231GU57_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactate utilization protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lutB_2</name>
        <name evidence="10" type="ORF">B7C42_07816</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778478.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40108">
        <property type="protein sequence ID" value="OXR40108"/>
        <property type="gene ID" value="B7C42_07816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="LUD_dom" evidence="7">
        <location>
            <begin position="83"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="323"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3390" evidence="8">
        <location>
            <begin position="408"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="481" mass="51905" checksum="564B2513AAB27877" modified="2017-10-25" version="1">MNDVFLGVPTPPGRSPLHAPIPFPEAARTAVADAQMRRNLGAATATIRAKRGRVVDELPDWEQLRTSARDIKRYTMAHLADLLEQFEQQVIARGGVVHWAADATEANRIIGDLVAATGATEVVKVKSMLTQEIGLNDALAARQITAHETDLAELIVQLADDRPSHIVVPAIHRNRSEIREIFAAAMPGFDPAAGDDPRALAAAARTYLRQKMLTAEVAISGANFAVAETGTLAVVESEGNGRMCLTLPNTLITIVGIEKLVPTAQDLEVFLQLLPRSATGERMNPYTSLWTGVHPGDGPQNVHVVLVDNGRVRTLADEHGREVLHCIRCAACLNVCPVYERTGGHAYGSVYPGPIGAVLSPQLTGVADNPSLPFASTLCGACYDVCPVAIDIPSVLVHLRAEVTATQRVPNGQSAAMATAAWVMRSPRRFAVATRSMRIARLLGRRRGSIGPLPPPLSAWTGARDLPRPPRQTFRDWWGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU69</accession>
    <name>A0A231GU69_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High-affinity branched-chain amino acid transport ATP-binding protein LivF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livF_3</name>
        <name evidence="5" type="ORF">B7C42_07796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778628.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40132">
        <property type="protein sequence ID" value="OXR40132"/>
        <property type="gene ID" value="B7C42_07796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="26413" checksum="325AAA64AF3718CB" modified="2017-10-25" version="1">MTTVLECRDLSAGYIKQRPCLRGVDLDVRPGEITCLLGPNGAGKTTLLSTLAGLLPRAGGEMRVEGADIVSGRPRAAVRAGVVLVPDDRALFRQLSTRHNLRLAVGERARRRTAIPEVLQYFPALEKRLSVDAGRLSGGEQQMLAIGRAILQRPKVLLIDELSMGLAPVIVREILDVLRALADDGMSVLLVEQHVHLALGIADRAAILVHGTVADSDTAEALRADPRRIERAYLGEAAEDTAAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU70</accession>
    <name>A0A231GU70_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phenylacetone monooxygenase</fullName>
            <ecNumber evidence="5">1.14.13.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pamO_3</name>
        <name evidence="5" type="ORF">B7C42_07755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.92" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40173">
        <property type="protein sequence ID" value="OXR40173"/>
        <property type="gene ID" value="B7C42_07755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033776">
        <property type="term" value="F:phenylacetone monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="459" mass="51509" checksum="5DE066B74AC9CC33" modified="2017-10-25" version="1">MASRKKVRETDRVCIVGAGPAGLSAARALKRLGIPYDQFERYSDVGGIWDLDNPGTPMYESAHFISSRKTSGFFDFPMPDTYPDYPGNRQILEYTRSFAAAYGLRDAIRFDCPVTDVQEDGDKWLVTLGDGSQLSYRAVICATGVTWQPRMPTHRGEFSGEIRHSSTYRSPLEFRNKRVLIVGLGNSGADIACDAAANADAAFVSIRRGYHLIPKHIFGIPSDELAHNGPQLPLWLQRPAFRAALRLTQGDLTKYGLPKPDHKLFESHPLLNSQLIHYLQHGDVAIRPDIKGFEGSRVRFADGSSEEVDLVLYATGYDWSIPYAEKYFDWNEGRPDLYLSVFNREHRNLFGLGYIEINSSAYTLFDHISNIVAQYLHDQDHAPARASAFDRMIAGDTPKLNGGINFLASARHRSYVDAHAYHKYLGTLRKRFDWQNLEPGLFEPIRSGRGIGTVSGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU84</accession>
    <name>A0A231GU84_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor YvoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_4</name>
        <name evidence="2" type="ORF">B7C42_07701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776373.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40187">
        <property type="protein sequence ID" value="OXR40187"/>
        <property type="gene ID" value="B7C42_07701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="25249" checksum="4DE196226F98CB19" modified="2017-10-25" version="1">MAEPAYVSIAGEYARRIRGGELPPGTQLPSYSEIAARNNVSDIVVRKALELLQSQGLVRSVRRRGVFVSDRPNLIRISPERQMEDPEVTFANETDSTVEIDRVTETVPATEALADALGVSVGEEITHVVTRASEDGRPISVSDTYQPADVTGTSDAATLEETVADSIPVPSHAEWLKTTPGDLVKTVHQRYMTATGRVIMVSDVSYPRDRYYAFVFRMNLKPELEAAAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUH9</accession>
    <name>A0A231GUH9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Virulence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_07795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778627.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40131">
        <property type="protein sequence ID" value="OXR40131"/>
        <property type="gene ID" value="B7C42_07795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="177" mass="19200" checksum="2902588E6DABC300" modified="2017-10-25" version="1">MRGINHVVLYVSDLRRSLDFYESVLGFRRLPGAFAGAAFLRHADSANDHDLGLFQSRDRATPVPGAVGLYHVAWEVDTLTELAALHERLVAARALTGAGDHGSTKALYGRDPDGIEFEVCWLVPDECVEQALAPGTPPTAPLDLAAEIERYGASTPGGPRTDPAVWERIAARYADEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV76</accession>
    <name>A0A231GV76_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40533">
        <property type="protein sequence ID" value="OXR40533"/>
        <property type="gene ID" value="B7C42_07342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="18845" checksum="644019FB6D9B05B7" modified="2017-10-25" version="1">MWAVTTTIDRPSVTTNSRQQTVISTAKIVSMSADVMATLQAFYAAEAAYLTEGAEFGEMARHLASDVVMYQAASLPYGGEWHGHDGFRKFIAAMGDSWDGLWFDEQQFLSDGDRVVVHSRGRLRARRTGRELKTSLLQWISFRDGLITEFRPYYHDTSAVLAVLDEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC6</accession>
    <name>A0A231GVC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Osmoprotectant-binding protein OsmX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">osmX_2</name>
        <name evidence="4" type="ORF">B7C42_07365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40556">
        <property type="protein sequence ID" value="OXR40556"/>
        <property type="gene ID" value="B7C42_07365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646856" evidence="2">
        <location>
            <begin position="28"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="53"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="329" mass="34748" checksum="2EB0041529D8971E" modified="2017-10-25" version="1">MKRPGKAARRAATAAATLLVAVVAACGLEAGGAVPLPVGPGSIAPIPALDGVQITVGSKDFTEQNILGYLIEFALTAAGAQVRDLTNITGSNSLRDAQLHGQVDVAYDYTGTGWINYLGNETPIPDSTRQFEAVRDADLAQHGMVWADPAPMNNTYTMVTDAGSAARTGATTISDYARLVNTDPSTGPTCLGTEFSVRQDGFPGLARKYGVDLGKVHKQIMQDSLVYSATANGTCQFGDVTATDGRTKALNLVQLTDDLNFFPKYNAALVMRKSFADAHPQVAQVMAPISALLTNETITELNRKVDVDAAEPATVAREWLIRQGFVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVG9</accession>
    <name>A0A231GVG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40606">
        <property type="protein sequence ID" value="OXR40606"/>
        <property type="gene ID" value="B7C42_07291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="39" mass="4125" checksum="F6A6B40F8A91C2CF" modified="2017-10-25" version="1">MVVYPITTLAVGCSADFEAVESFDSTARTERLLRSSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVW4</accession>
    <name>A0A231GVW4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40712">
        <property type="protein sequence ID" value="OXR40712"/>
        <property type="gene ID" value="B7C42_07270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="23571" checksum="FABA6665F8F21697" modified="2017-10-25" version="1">MQASDLDGAVRRDLLSLDKNNAEAVARHLVMAARLLDEDPEQALEHARAARRRAGRIAVVRETAGVTAYHAGEWAEALSELRTARRMSGGSGLLAVMADCERGLGRPERAIELGRSDEARALSGDEATELRIVVAGARMDLGQYDQAVVTLQTPELEPSRSGPASARLFYAYAEALLAAGRSDEALQWFLNAAAADVDGDTDAEERADELAGAQVDDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD1</accession>
    <name>A0A231GWD1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40791">
        <property type="protein sequence ID" value="OXR40791"/>
        <property type="gene ID" value="B7C42_07074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="229" mass="25625" checksum="93A32E375E4C7372" modified="2017-10-25" version="1">MSTTALPPVVDAETWQRELDALRVREKAATRELDAIAAARRRLPIVRMPDYTLEGEEGPVRLADVFDGRSQLIVYNHMWFPGETWQCPGCTGFTSQFTRLEFLDNWDARFVIVTQGPIDEALAYKRRVGNAMTWYSTANSSFGTDVGAPPGGGFAVNVFLRDGDTVYRTWHTDGRGTEQLGYTFALIDLLPYGRQEEWQDSPEGWPQSPTYSKWSGSKEIAAAYGEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWH8</accession>
    <name>A0A231GWH8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40922">
        <property type="protein sequence ID" value="OXR40922"/>
        <property type="gene ID" value="B7C42_07057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="31959" checksum="159DDB6765DE8ACD" modified="2017-10-25" version="1">MSAPTPIVSVEPVTLSAPERGVDLQVRVSAPVRGSGLPIVVLAHGFGQTMSSYDPLVDHWAANGFVVVQPTFLDARPLGVTADDPRYPDIWRIRVTDVVRVLDDLDRVVAAVPGLGERIDRERIAVAGHSWGGQTVSMVLGARVLGADGRPGPDMTDPRVKAGVLLATAGLGGDDLTPFAVANFSFMNPDFDGLATPALVVAGDHDQSQLSTRGPDWFTDVYTHSPGAQSLLTLFGGEHSLGGIHAYNAADTTDESSERVALIREAAWAYLRSALGIDTAAWEKVQAELAGTADPIGRIDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWK7</accession>
    <name>A0A231GWK7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_06970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517257.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41004">
        <property type="protein sequence ID" value="OXR41004"/>
        <property type="gene ID" value="B7C42_06970"/>
    </dbReference>
    <dbReference type="GeneID" id="66723729"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="21496" checksum="BD003EC322D2CD44" modified="2017-10-25" version="1">MALLTIGDQFPAYNLTAVIGGDLSKVNAQQPDDYFTQVSSDDYAGKWRIVFFWPKDFTFVCPTEIAAFGKLNEEFADRDAQVLGVSVDNEFVHFQWRAQHEDLKTLPFPMLSDLKRELVTATGVLNADGVADRATFIVDPNNEVQFVSVTAGSVGRNVDEVLRVLDALQSDELCACNWKKGDPTIDAGELLSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWN9</accession>
    <name>A0A231GWN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative helicase HelY</fullName>
            <ecNumber evidence="3">3.6.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">helY_2</name>
        <name evidence="3" type="ORF">B7C42_06964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40998">
        <property type="protein sequence ID" value="OXR40998"/>
        <property type="gene ID" value="B7C42_06964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="223"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="835" mass="92535" checksum="2BC3362152C1C250" modified="2017-10-25" version="1">MQLSELVPDRAVPDVDADWLYETFAEWTSAQGLTLYPAQEEALIELMTGANVILATPTGSGKSMVAVGAHFAALNRGERSYYTAPIKALVSEKFFALCEVFGADKVGMVTGDAAVNPTAPIICATAEILANLALREGADADIGQVVMDEFHFYADPDRGWAWQVPLLELPRAQFLLMSATLGEVEHFARDLERRTGRSTAIVTGSERPVPLLFSYVRTPITETLEDLVTTSQAPVYVVHFTQAAALERAQALTSVNFASKAEKDAIAQALGGFRFATGFGKTLSRLIRHGIGVHHAGMLPKYRRLVERLAQDGLLKVVCGTDTLGVGINVPIRTVLLTGLTKFDGVRTRRLKAREFHQIAGRAGRAGYDTVGTVVVQAPEHEVENARLVAKAGDDPKKLRKIQRRKPPEGFVSWSEDTFDRLVAAQPEPMVSRFRVTNSMLLNVIARPGNCFDAMRHLLEDNHEPRPAQRKHILKAIRLYRALRDAGVVQQLDEPDATGRRARLTVDLQRDFALDQPLSPFALAALELLDKSAPSYTLDVVSIIESTLEDPRQLLLAQQHRARGAAIAEMKADGIEYDERMELIEDITWPKPLAELIEPAFETYRAGHPWVSEFSPSPKAVVREMIERSLTFAELISQYELARSEGLVLRYLADAYRALRRTVPESARTEELEDITEWLGELVRQVDSSLLDEWEQLTNPGAETDDDQLAFGADTVRPITANERAFRVMVRNSMFRRVELAARQRWDELAAFDDGPDWADDLAPYFDEYGAIGTGPDARGPALFAVETRPGFWRVRQVLDDPAGDHGWVLEAVVDLAESDAAGEVVFDEMTVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWW1</accession>
    <name>A0A231GWW1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41089">
        <property type="protein sequence ID" value="OXR41089"/>
        <property type="gene ID" value="B7C42_06859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9282" checksum="8F775E3525F8A23E" modified="2017-10-25" version="1">MEDLSRAAGAASTLSKLVVRQQTREVLDHFGSCPECGYAANAFMNVTYYADGTATVTTRGTCGLPCGWSGPTEVTKMTGPTSPRVDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWX4</accession>
    <name>A0A231GWX4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_06977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR41011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41011">
        <property type="protein sequence ID" value="OXR41011"/>
        <property type="gene ID" value="B7C42_06977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="79"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="303"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1366" mass="150801" checksum="51C93F44DF61A30B" modified="2017-10-25" version="1">MTSTATTRELRARLADLSLRDEHRLRRQLDKARGNDGEIERLEREIAAAQARIETRRGAVPVIRYPEQLPVSAHRDDIAAAIAAHQVVVIAGETGSGKTTQIPKICLELGRGIRGTIGHTQPRRLAARTVAERIAAELDTELGDVVGYTVRFTDQASDRTLIKLMTDGILLAEIQRDRLLRRYDTIIIDEAHERSLNIDFLLGYLRSLLPKRPDLKVIITSATIDPELFARHFADPVSGEPAPIVEVSGRSYPVEIRYRPLAPEMTGTDDEDEFEEEPAPRRGRPSGRAAEDARDQTDAIGDAVRELLAEGDGDVLVFLSGEREIRDTADTLRDLKLPRTEIVPLYARLSAAEQHRVFQPHTGRRVVLATNVAETSLTVPGIRYVVDPGTARISRYSMRTKVQRLPIEPISQASARQRSGRCGRVADGICIRLYSEEDFEARPAFTEPEILRTNLAAVILQMTALGLGDIESFPFVEAPDRRAIRDGIALLLELGALGRPGETPARGARRRRGRGSDAAAGSHVRAPEGGDELVLTAVGRQMAQLPVDPRMARMLVAAEANGCLSEVLVIVAALSIQDVRERPAEFQQAADTKHARFTVEGSDFLAYLRLWDYLRGQRKSLSSNQFRRMCRDEFLHYLRIREWQDLQGQLRTITKSLGWAAAESIAPQQNPEALPWDGEGIHRALLAGMLSHIGVREAESREFLGARGAKFMIFPGSALAKKPPRWVMAAELVETSRLWGRMAARIEPEWAERLADDLVKRNYSEPHWSSRRGAAMAYERVTLYGIPLVTQRRVDFGRIDAQLSRELFIRHALVQGEWQTRHGFFHRNRELLDDVADLEHRARRRDILVDDQVLFDFYDQRIPADVVSVRHFDSWWRKTEREDPHLLDFSTATVVNAQAAQLDPAAYPDSWRQGELSFPLTYQFEPGQADDGVTVHIPVAQLAHVRAVGFDWLVPGMREELAAALIKTLPKQLRRSVVPAPDFARAALARLTPRAEPLRTGLSRELSALASTSIAPADLDPGALPDHLRMTFAVTGPDGADLARGKSLAALKTQLSQQVSQSVAKATSAAERAPATVWTAQTLGTVPQTIRREVGGQTITGYPALVSEDDGVAVRVLSSPAAQRAAMRTGTRALLLREMPAAQRSVTSGLSAADRLALSQNPYGSMDALLDDCRACAADELIAAHGGPVRSPEQFTRLVDQVRPQFAGAVARVLALVVPVLAAAHRVRTALADTTDRDIADDVAGQLDELVFAGFVSEFGTTRLREIPRYLHAAEARLLALPASADRDRQGAAELDRVHAAYARLLDRLPGARRTAADVTEIWWMIEELRVSLFAQQLGTPYPVSAKRIVKAIDGIGAAPAGARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXC1</accession>
    <name>A0A231GXC1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glycerol-3-phosphate dehydrogenase 2 [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA2</name>
        <name evidence="7" type="ORF">B7C42_06681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41283">
        <property type="protein sequence ID" value="OXR41283"/>
        <property type="gene ID" value="B7C42_06681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="6">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="183" mass="19010" checksum="1BAEEE7A3CBCF8DE" modified="2017-10-25" version="1">MPDPDYAERLAGLFRTSRYRVYSSTDVVGVELCGALKNVYAIAAGMADGAGAGYNTKAMVITRSLREMASLGSALGGELATFSGLAGNGDLIVTCMSPRSRNRRLGEALGRGLTIEDALATLTQVAEGAGAVGVVKRLADRVGVDASLVREVDAVVDHGATVADAYRGLLREIPGHETHGSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXG2</accession>
    <name>A0A231GXG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.90</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xylB_3</name>
        <name evidence="4" type="ORF">B7C42_06687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.90" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41289">
        <property type="protein sequence ID" value="OXR41289"/>
        <property type="gene ID" value="B7C42_06687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018456">
        <property type="term" value="F:aryl-alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="37537" checksum="AD19BEEC180CE2C7" modified="2017-10-25" version="1">MQALAAVARAPHSDFSLETITIDGPKPGEVLVKIEAVGICHTDLAARDGALPVALPAVFGHEGCGVVEAIGEGVTKVAPGDRVAITFASCGYCPACRADSPSYCHNFMHLNYAGVRADGTGPLSAGAEAITGLFFGQSSFATHSVALERNVVKAPSDLPAEIIAPIGCGIQTGAGAVLRSLACRPGSSLLVAGAGSVGLAAVMAAVVRECATIIVIEPHASRRELAIELGATHAIDPAAGPVAEQVRAIVAAGVDYAIDTSGMPAVIDGLVKSMTFHGKLGLIGVPADPEAALPISVIETLVLGLTVVGIIEGDSVPDEFIPELIELYRAGRFPIDKLVTTFDFAKINDAVAAQHRGEVLKPVLVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXN3</accession>
    <name>A0A231GXN3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">log_2</name>
        <name evidence="2" type="ORF">B7C42_06468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41325">
        <property type="protein sequence ID" value="OXR41325"/>
        <property type="gene ID" value="B7C42_06468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="19884" checksum="F89B8B6EC083D5EF" modified="2017-10-25" version="1">MVSGQPFAVCVYCSASAADPDALRLAAEVGSEIARRGWQLVSGGGHVSMMGAVAVAARAGGARTTGVIPKRLVHQEVADVDSDELIVTDTMRERKQIMEDRADAFLTLPGGIGTLEEFFEAWTGGYLGLHGKPLVVLDPNGHYRGLFAWLDELCAAGFIGRPALDRITVTADVASAFRALTAPRIDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXP1</accession>
    <name>A0A231GXP1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450-terp</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41291">
        <property type="protein sequence ID" value="OXR41291"/>
        <property type="gene ID" value="B7C42_06689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="440" mass="49684" checksum="061FF204C4DD35D3" modified="2017-10-25" version="1">MSTTEQATELIPDTVARQIVLPEGHRDNDALFEAYRWLRENNPLGRAVVEGYDPLWLVSKHADIMEIERQPDIFTSAGGEDKGSVNPILANQAGDAFTKSINNGSLRILETLTYLDPPEHTEIKDIALDWFRPQNLAQWESVIRELAKSAVARLLETDGRIDFVKDFALQYPLHVIMSLFGVPESDEPRMMSLTQEFFGTADPDAARGDVEQLTPDAAAKQWVATIQDFFAYFETLLQDRRRNPRDDLATIIAQARNSDGEYYPNEVAYGYFIAIATAGHDTTSSTLAGGLLELARHPDQLELVRNDLSLVPHLVNESLRWASPVKHFMRMATQDYTLRGREIHAGDRFMLLYQSGNRDADANPDPDRFDLTRRPNKHIAFGYGPHMCIGQHLAKLELRVMLEELLPHVKSITPTGDPRFIQTNFVGGLKNMPVAIEFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXU2</accession>
    <name>A0A231GXU2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41341">
        <property type="protein sequence ID" value="OXR41341"/>
        <property type="gene ID" value="B7C42_06484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="164" mass="17823" checksum="D1E8063D44ED106A" modified="2017-10-25" version="1">MRSLSRSQPVRTATSTATTGRFFRREPAPAAAVGRYRTVAYRVATGAIVAEAAVGGVWDLARIPFVTDVVTHLGYPRYFLVLLGVWKLPAAIVLAAPRLPLCKEWAYAGTFFVYTGAIASHLVTGYARAEVGVLSAMTLLTVTSWALRPADRCLPGRQPLRMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY24</accession>
    <name>A0A231GY24_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pnbA_2</name>
        <name evidence="3" type="ORF">B7C42_06574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41431">
        <property type="protein sequence ID" value="OXR41431"/>
        <property type="gene ID" value="B7C42_06574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="522" mass="56222" checksum="84277FE89E05D2F1" modified="2017-10-25" version="1">MSTQFFEATPVEDTAGPVAHTTSGAVRGFRTGSVNVWRSIPYAAAPAGPKRFARPEPPEAWSGVRDCTEFGEIAPQTMGDMVPVDSGLRMGEDCLWVNVWAPAAEPVQPRPVMVWLHGGAYCLGTAAQAIYDGRRMVETCDVVIVAVNYRLGALGFLDLSSLGDGFVANLGLHDQIAALEWVRDNAAAFGGDPGNVTVFGESSGAGCVTALLTSPRAAGLFHRAIAQSPPATTVFGPDRAAGVASRFLELMDLPPERAQELLECPIERIVDAAGVLLDEVPLQSPGRLAAAPVVDGDLLPTYPTDRFQQGRSHRVPLIIGTNKDEASLFRLFRSPIMPVTPDAVNAMLNAVAGEHPGLSHERIAEITSAYPDLAKTRGALAMSTDAAFRMPAHWVADAHSRHSRTWMYRFDQATPMLKAARVGAGHATELPYIFGNFGSFDHDPTFWLGGRKVASEVSGRMMRRWLAFAEHGVPAALDGSKHWPPYRESTRTTLVVDAVDRVLDDPDHDLHTAWGDQAVGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYX1</accession>
    <name>A0A231GYX1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780757.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41806">
        <property type="protein sequence ID" value="OXR41806"/>
        <property type="gene ID" value="B7C42_06148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011266093" evidence="2">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="23030" checksum="2A2FD05C0EFB0F9E" modified="2017-10-25" version="1">MKIRISTIAAVCAATLAAAGTAAADPAPAVVSYHAETTDSRSVTVELTHGTFAVDPDGTAVTIRDEAGRALYALPLAYAIGDQRMPIREQIGEDATTLTLTPDTAGVRRDALTPVASPLENQLAMNDLVNAVSIGTSVGALIGTAVGAVLGVGLGIALAGASCAVLSVACVVAVLPIVSLAGAAGGVAGLVLGGGPTTAVGLYRYVTTLLAPPGTSEYASDLRGRPGVPDTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYZ8</accession>
    <name>A0A231GYZ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41818">
        <property type="protein sequence ID" value="OXR41818"/>
        <property type="gene ID" value="B7C42_06160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14769" checksum="A851DA4728370299" modified="2017-10-25" version="1">MFDSPTPISTPVVDAMRAGGSWNPLWDQLYEWDPEWTERFMAMNATPIARHIFPPEFVELLSIAIDAACTHMYAPGIRRHIRAALDLGVPPEQILTVLQMVSVLGIHACNLGIPILAEELGTPLTPTPRQADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ94</accession>
    <name>A0A231GZ94_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">azoR</name>
        <name evidence="2" type="ORF">B7C42_05918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41934">
        <property type="protein sequence ID" value="OXR41934"/>
        <property type="gene ID" value="B7C42_05918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="155" mass="17065" checksum="8B6EF2975B89DFD9" modified="2017-10-25" version="1">MLAHGATDLDRLGELVNSPAQQRAWAIVEPLLAELRAADIVLIGTPMYNYSIPAGLKAWLDQITFPRMSLAPTRFVVASARGGAYSPGTPKAIYDYQERYLRDFFAGHFAVEDTVFVHSELVNSRQDPALAHLRDKHDASHAAALATARTLGKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ95</accession>
    <name>A0A231GZ95_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG_24</name>
        <name evidence="2" type="ORF">B7C42_05879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779060.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41895">
        <property type="protein sequence ID" value="OXR41895"/>
        <property type="gene ID" value="B7C42_05879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="25438" checksum="0A85E4A551E19D28" modified="2017-10-25" version="1">MSAESARVAVVTGGGRGIGAAIARRLGADGFSVVVNYSASEEPARRVVEEIAAAGGKATAIRADVSDADQAAELMEQATAEFGAPTVLINNAGMNLFGSARQLSPEHWDRVIGVNLDGAFYCTHAALPAMYENGWGRVLFVSSPSGGRRPSPGMSAYAAAKAGLAGMTRVMAQEVARRGVTVNAVMPGFVETDIIASGGSDAARTLADHWPRIPAEAIADTVSFLVSDAGQHVSGEEIGVWLGGPVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZH9</accession>
    <name>A0A231GZH9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymethylenebutenolidase</fullName>
            <ecNumber evidence="2">3.1.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clcD_2</name>
        <name evidence="2" type="ORF">B7C42_06011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042718.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42027">
        <property type="protein sequence ID" value="OXR42027"/>
        <property type="gene ID" value="B7C42_06011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008806">
        <property type="term" value="F:carboxymethylenebutenolidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="27718" checksum="7A83F55E064D253F" modified="2017-10-25" version="1">MTEEIVGRHAEVEVDGSPMAVYLARPARGGRLPVVLVGAELWGLTAEVRAVVDRVAALGYVAVVANLYHRCGPETAAGLAESDENRARAFDLLGTLTRDGVEADLRAAVAFAREQGEGGDTTGALGFSLGGHITYFAATRLDLDAAAIFYPGWLPVAGTALSIPDPLLAHTSSIAERGTRLLLLLAERDHVIDAEQRAAIDAALAQAGADYELVVYPSAQHAYFFPGRPVHDAAAAADSWQRVTELFAATLGAVTDEFPAPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZR5</accession>
    <name>A0A231GZR5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neutral ceramidase</fullName>
            <ecNumber evidence="3">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_06026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42042">
        <property type="protein sequence ID" value="OXR42042"/>
        <property type="gene ID" value="B7C42_06026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102121">
        <property type="term" value="F:ceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="PTHR12670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850511" description="Neutral ceramidase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Ceramidase_alk" evidence="5">
        <location>
            <begin position="41"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Ceramidse_alk_C" evidence="6">
        <location>
            <begin position="526"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="687" mass="73128" checksum="CD03622691942904" modified="2017-10-25" version="1">MTFTRRSMLAGTVTAAVAASVGATASAEAAPIRVTGDEAGYLVGAGIADVTGAVAGQGMMGYSELDQVATGLLMRTWARAYIVVDRASGERVAFVNADIACLFQSVHLAVMQRLAQRFGALYTERNVNLNATHNHNSCGGTAREYAYSLAAYGFQNNSHQAEVDGIVAALVAAHENLAPGTLSLGHGELHDASANRSRVAFDLNPPDDTAAFPNAIDPQVTVLRLRQGGNDIGAITWFATHGTSLTDANTLISADNKGYASYRWEHDEMGVRPGAGKPGFVAAFAQTNAGDMTPNIGLTPWHPSGPTEDNRLNCSLIGERQYRAGRAAFDAARPMRSGGVDAALRYLNMADIAIDGSYTPDGKPARTAPAMMGAAAAATSSEDNWKTQLSFLQEGNANPVVAALGGLDGPVEQWMRDVQAPKLIVAPLGVLPPRPWVPLTVPIQILRIGDLVLASGPAEYTVVSGLRIRRVVAHALSVPLENVLLQGYANGYCGYVTTPEEYASQQYEGGETLYGRWTLPAYVQEFDRLARAVAARVDLGRGPAPLDWTAGIQPNLLPPVPADAPMTGRAFGEVIIAPKPGYGHGETVTAEFCGAHPANDFHTGGSYFEVQRAEGEQWRAVFDDNDWCTELHWSRPPGQPEASRVAIHWTVPADAEAGRYRIEYRGDRRDGAATVPFTGTTAEFTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0D5</accession>
    <name>A0A231H0D5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">greA_2</name>
        <name evidence="7" type="synonym">greA</name>
        <name evidence="11" type="ORF">B7C42_05533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780623.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42334">
        <property type="protein sequence ID" value="OXR42334"/>
        <property type="gene ID" value="B7C42_05533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="84"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR42334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="164" mass="18042" checksum="B974B38F85F90357" modified="2017-10-25" version="1">MTETQVTWLTPESHERLKSELDALIANRPVIAAEINERREEGDLKENGGYHAAREEQGQQEARIRQLQELLNNAKVGVAPTKSGVALPGSVVKVYYDGDETDTETFLIATREEGLGQSDLETYSPSSPLGGALIDAKVGETREYRLPNGNMMKVTLVSAEPYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0G3</accession>
    <name>A0A231H0G3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_05517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030518151.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42318">
        <property type="protein sequence ID" value="OXR42318"/>
        <property type="gene ID" value="B7C42_05517"/>
    </dbReference>
    <dbReference type="GeneID" id="66724476"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="98" mass="10971" checksum="5B306CFE9880AF9C" modified="2017-10-25" version="1">MTEFGGIPPRIDTDPESVERGLVTLVLTLVELLRQLMERQALRRVDAGDLTDTQVERIGTTLMLLEQRMAELREHFGLTPEDLNIDLGPLGPLLPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0V0</accession>
    <name>A0A231H0V0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42466">
        <property type="protein sequence ID" value="OXR42466"/>
        <property type="gene ID" value="B7C42_05242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="26931" checksum="D08D91BF6148B189" modified="2017-10-25" version="1">MSVESRLSPRRHVLLELGFATRRAGDEVHGSATIVPELHAPGTMHLRTSILATWADTVAGLLASLVMHPRVPVTLELDVHLYRPAPAAGQLEAIGRTVKVGRSVFVAEIDFAVDGEPLGLAGASFMVAPDPDLHLPRALSLDMPAGRDRLTTPLAERLGCERVRPGVAVLPRTDEVLNAAGSVNGGLIAVAAEEAVLSLAPGDSLAFLGLRYLQPAKVGPVTATATVRGGVGRVDLRDTGSDDRLATIATARTFGAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Y4</accession>
    <name>A0A231H0Y4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mak_N_cap domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778085.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42482">
        <property type="protein sequence ID" value="OXR42482"/>
        <property type="gene ID" value="B7C42_05258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="187" mass="19873" checksum="92A73CF4EB2857AB" modified="2017-10-25" version="1">MAVVHHTTLEPGKLELLTAWLPTREWFTGTTPHLHKAGGFRLDDPDGEVGIEHMLVVDTADARRPVYHVPMTYRGAPLPGADAALIGTSEHGVLGTRWIYDAAHDPVALAQMAALLSGRAVAQDQNLSDTPDRTVEVSAVAAATPKTVRVNRIPPRSAASAHGWVRVGWTDAEGTAAEGVVLEAAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Z9</accession>
    <name>A0A231H0Z9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778136.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42523">
        <property type="protein sequence ID" value="OXR42523"/>
        <property type="gene ID" value="B7C42_05299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="18909" checksum="547668B7F5F3E987" modified="2017-10-25" version="1">MEQHTITEILNRPISRELLSRDLLRLAYVAKDGTPRNIPIAFTWNGSQIVLCTTKNAPKLHSLRHNPQVALTIDTEVHPPKILLVRGRAELDVVDGIPEEYLQMNGSYEMTPEQRVEWEAEVRSLYDGMVRIVITPTWAKLIDFDTTLPTAVEELVRQRAERQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H139</accession>
    <name>A0A231H139_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777345.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42568">
        <property type="protein sequence ID" value="OXR42568"/>
        <property type="gene ID" value="B7C42_05345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011278888" evidence="1">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="180" mass="17462" checksum="9C8FD56BF2995BCA" modified="2017-10-25" version="1">MRAKKFAATALLAVGATTAAAGVVQAAPATASEIAVRGVEQGVGFVTAPTADHTGLTTTVDAGSFTVTGDSVTLIDAAGRAVASVPLGLRTASGTVGLTPRVENAGRTLTLTPQSATERTAQAIDEASDTLARKQYNAGVGALVGAGIGAVLGFFLGGVGALITIPIGAGIGALIGYSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H164</accession>
    <name>A0A231H164_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42605">
        <property type="protein sequence ID" value="OXR42605"/>
        <property type="gene ID" value="B7C42_05382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="94" mass="9786" checksum="F9E7E1F20931C96C" modified="2017-10-25" version="1">MPLLTVRLAADPTLAAALRELHLTEAEVDLDYGLVAVDTDQHLYALRVSDAAATRAAAVSDTAEIFADPRIGPAHDAGPDTSSPRLPPDDSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H199</accession>
    <name>A0A231H199_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42629">
        <property type="protein sequence ID" value="OXR42629"/>
        <property type="gene ID" value="B7C42_05407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="96" mass="10313" checksum="FF91C1920CBCCF4C" modified="2017-10-25" version="1">MFSSRIGARAKALPRTAIGRATPPRAPQPLPRFGGLLPPLPLGSNPANVDAPWELSLTPEGIYYALRYFARKFPGAPLFIVESGMPTDNGRPRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1A8</accession>
    <name>A0A231H1A8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-aminohexanoate-cyclic-dimer hydrolase</fullName>
            <ecNumber evidence="2">3.5.2.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nylA_1</name>
        <name evidence="2" type="ORF">B7C42_05374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.12" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42597">
        <property type="protein sequence ID" value="OXR42597"/>
        <property type="gene ID" value="B7C42_05374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019874">
        <property type="term" value="F:6-aminohexanoate-cyclic-dimer hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="474" mass="49660" checksum="A809AAB324926BB3" modified="2017-10-25" version="1">MRDLFDHTDMTGLAAAIEAGDVSAEEVLEFSLSRLAERNPAINAVVSERGDQARREVTAGLPDGPLRGIPFVIKDLHMDVGGLPTTNGSRLFADAVATADSELVQRYRRAGMVIIGKTNSPEFGLNASTEPVLFGPTRNPHRLDHSAGGSSGGSAAAVAAGIVPAGQASDGGGSIRIPASSCGLVGLKPSRGRVPAYPARTLLAAPMSVNHALTRSVRDTAILLDIGAGAVPGDPYVIAGPSMRYVDAMRIDPGHLRIGIATTLPSGAAVHPDCFAATRDIAGVLADLGHDVVDEAPDFPFEEIMTGLQYLMAVPVAVEVKARLAALGRDLRDDDLEPMTRMIYDGANQDSAADYVRALRDLETAATMLGGYFADHDLLLTPTLGTVVAPLGLLDTTDPASLWEHAMSFSGMTSPFNVTGQPAISLPLGTDSTGMPVGIQLVAAFGREDLLLQVAAQLEQARPWRTTPVWPPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1C6</accession>
    <name>A0A231H1C6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42648">
        <property type="protein sequence ID" value="OXR42648"/>
        <property type="gene ID" value="B7C42_05426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="23"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="25859" checksum="27CFBDF00C8CF6A7" modified="2017-10-25" version="1">MAGVMVGLRGAGIDPARADRIVGTSAGSVVGAVLAAGGDLEHLGAARSPGGESFAPDPRRLAEIFSLRTTSGDAREIRRRMGELALAADAGDPGAHVERIARLAGVTEWPDADLRVTTIDIGAGELQVWTRDTAATLPQALAASTAVPGVFPPIPIGESRYFDGGVRSALNADLAAGAEIVVIMEPLAHMFPRTRADSTHGAATEISLAPDADAVAVFGFDVFNPAALAPAYEAGLRQSADAAKQLADVGFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1L8</accession>
    <name>A0A231H1L8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="1">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ogt_2</name>
        <name evidence="3" type="ORF">B7C42_05081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42744">
        <property type="protein sequence ID" value="OXR42744"/>
        <property type="gene ID" value="B7C42_05081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="2">
        <location>
            <begin position="79"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17057" checksum="A41A72A2EF1D2C0C" modified="2017-10-25" version="1">MTVYTTTASPLGELMLVGELRPAGVALTALSIAGGKGAGAQSDWVEDQAPFVSVLDQLDGYFAGQRTRFELDYAVGGSEFRRRVWQALDDIPYGRTVTYGDIAARVGAPRAAMRAVGAAIGANPVLIVRPCHRVIGANGRLTGYAGGIDRKRQLLELEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1M7</accession>
    <name>A0A231H1M7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776873.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42754">
        <property type="protein sequence ID" value="OXR42754"/>
        <property type="gene ID" value="B7C42_05092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="503" mass="53988" checksum="58341DF224CDC901" modified="2017-10-25" version="1">MASALSAIEQQVADHRRAAAQQRSAEAELRLATSLCELARACLDTKAEGADRDRAPAALEPAQEAVLIRLHWLTAGHVTAQFAGQVTEALRLFEQAARTIGHRELATATIRQACDAYHQVAQNYPMAAGVCADGLSKCGVWLCRLDPESAVAASAEAVRIRAGLFAANPDQAGRYLASLNMLLRTLMIGRGRKQALATYRERYSAWTTPEMTTRLRETSIDELEFTSKTHAALVKLECPTLERAGYLTQQQILYQTAGDLTTIEEINWKLGLVGLKPLAAGALADPPSKPLEIATSYGALSVRCAAADAVARVRAAVIEAYAADGAHPVDSSAFAGVGETHWHMPDPALNTAANLGDDVVLLQRAGSWVHVLSLFWELAPTGKNPLALRLSRQWPVLAVNTIENLTYELCWYADGAARQFAALGRPAGQEPLAEPLAPLDFAMLADYGADYASETQVRAAFGNSGMFAKLTNLPASGIRQAGQARALADYGDQILFFRGAPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1U6</accession>
    <name>A0A231H1U6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42816">
        <property type="protein sequence ID" value="OXR42816"/>
        <property type="gene ID" value="B7C42_05154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="42653" checksum="78DDAA1B9C37E64E" modified="2017-10-25" version="1">MLAPERRTRADLYAAVAIAVVVAIAAVVVWSTSDARGTESDPAAHPASVAPSADRLPDALTERWHAPDDVAARALTSSGVAITGDGGTVRGLDAATGRELWKYQRDLPLCALESQFATVIATYRDPRGCSQTTMLGAEDGRRRTARSSYMDSQVRLSTDGTYVLAQGPRRLEVWRSDLVRTLEYGYVDAQVNPHTQPRHGCTLLSAASGGSRLAVLERCPDDAADRLTVLNPAPKDASAPEEYGSHVVTEPGAAAANARVVAVTDNRIALYLPGTDAAPPEFAIYDTNANSLAVHRLTAPIADNSTVTRLGSAYFVFTGNSVIALSASTFEPLWTAPDALGAPAMMAGNVLVPVADGIAALDPGSGAQQKRIPLRRSDYHGEPISLAVSGPVVLELRGGRLYGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1V3</accession>
    <name>A0A231H1V3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase (NADH) small subunit</fullName>
            <ecNumber evidence="6">1.7.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nirD</name>
        <name evidence="6" type="ORF">B7C42_05168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.15" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036504441.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42830">
        <property type="protein sequence ID" value="OXR42830"/>
        <property type="gene ID" value="B7C42_05168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017881">
        <property type="entry name" value="NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40562">
        <property type="entry name" value="PTHR40562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="130" mass="13460" checksum="A12D15612EA62286" modified="2017-10-25" version="1">MTVIDTPGFAPATTTGWTSACRLDYLIPGRGVAVLLRGGRQAALFLLPDGTLYAVGNIDPFGRAAVMSRGIVGDRAGVPVVASPLLKQSFSLLDGRCLDDDSVALPVYGVRVVDGVVAVTNEPVQYGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Z8</accession>
    <name>A0A231H1Z8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nudC_2</name>
        <name evidence="5" type="ORF">B7C42_05207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780168.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42869">
        <property type="protein sequence ID" value="OXR42869"/>
        <property type="gene ID" value="B7C42_05207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="156"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="308" mass="33476" checksum="0615BB7C9481CDC6" modified="2017-10-25" version="1">MSVFELNGLPLLSRSALDRAETLRSDEQALKQGWAEAKLVRMNRRGQVRIDGDQLVLEAALDYASEPVPEAVLLGVVDGAHIWAVRDNELEGRLMDLRVVGTTLHLDDVILGILSTALALLNWHDRAGYSAVDGSPTTVSNAGWSRVNASGHEEFPRIDPAIICLVHDGGDRVLLGRQQNWPEKMFSLLAGFVEAGESLERCVEREVREEVGVAVRDIRYLGSQPWPLPRSLMLGFAAVADPDAPLVFSDGEIAEAHWFTRDEVRTALAAGAWGSVTGDTGNAEQQRLLLPGSISIARTIVESWAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H292</accession>
    <name>A0A231H292_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42964">
        <property type="protein sequence ID" value="OXR42964"/>
        <property type="gene ID" value="B7C42_04850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="10183" checksum="8E6D6535FF705F1A" modified="2017-10-25" version="1">MRGRVPVRRSGAIRGNAVHSETGPEIPTVQLIPETGLASIPCGWLLPELPTALLIAVFVGTGWVGYAASDRPIPDPPLTVVVAPGDRDSLSVTFGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2D1</accession>
    <name>A0A231H2D1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoserine phosphatase RsbX</fullName>
            <ecNumber evidence="2">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsbX</name>
        <name evidence="2" type="ORF">B7C42_04889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778456.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43003">
        <property type="protein sequence ID" value="OXR43003"/>
        <property type="gene ID" value="B7C42_04889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039248">
        <property type="entry name" value="Ptase_RsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35801">
        <property type="entry name" value="PTHR35801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="21681" checksum="192554B287F919E6" modified="2017-10-25" version="1">MHDDGSVGTVEWAVAGRALPGQRVSGDRSVVLDAGDGSVLFAVLDGLGHGAAAADAADRAAQVLADNRAEPLDVLMVLCHRAMADTRGAAVSLVLFTGDDELQWLGVGNVESRVVAIGPGKPEVRATALLTGGIVGYLLPPNLQTQTVAIRPGDVLVMSTDGIVSDFVDTLDLARPTTDIADDILRHHVKDTDDALVLAARHRGPIAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2D3</accession>
    <name>A0A231H2D3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43009">
        <property type="protein sequence ID" value="OXR43009"/>
        <property type="gene ID" value="B7C42_04895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="56"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="28283" checksum="42ED3032145C9A3B" modified="2017-10-25" version="1">MRRMERTFEELLGDAAAAPVDGWGFEWLNGRATEQRPSWGYQRSMSARLATATAALDLETGGGEVLAEADTFPPTMAATESWAPNAAAATARLHPRGAVVVATTADAPLPFADAAFDLVTSRHPVVVRWAEIARVLRPGGTYFAQHVGPASVFELIEYFLGPQPEARRRRHHDDEAAAARAAGLRIVDLRHERLRMEFLDIGAVVYLLRKVIWLVPGFTVERYRDRLRELDDRIRREGPFVAHSSRTLFDAVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2I2</accession>
    <name>A0A231H2I2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_04945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777969.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43059">
        <property type="protein sequence ID" value="OXR43059"/>
        <property type="gene ID" value="B7C42_04945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="325" mass="34200" checksum="45CD9420ACD6EE40" modified="2017-10-25" version="1">MNATAPVFAGLALLLAGPVPALLSRATWPYRTPRAALVLWQAVALAAVLSAFGSGLAIASLLLVPGPDGRPTTSPTKEIDALGLGLWLIYVVVFALTLLVGARLIYASIRVGVHTRRRRARHRMLVDLLDQGGDPNHGDLIATSPLAGTRAADIRVLAAAEPIAYCLPGLRQRVVLSQGTFANLSKSELTAIVSHERSHLRARHDLVLEAFTAAHEAFPRVVRSKSALDSVKLLIELLADDSAVKVTGPTPLARALVTCSNSTAPQGAMAAGGPTTLIRIQRLTGPLGDLRIATAAYATAAAILVVPTLAVAIPWLVELNRLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H310</accession>
    <name>A0A231H310_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acryloyl-CoA reductase (NADH)</fullName>
            <ecNumber evidence="8">1.3.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acrC_6</name>
        <name evidence="8" type="ORF">B7C42_04673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.95" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43251">
        <property type="protein sequence ID" value="OXR43251"/>
        <property type="gene ID" value="B7C42_04673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="238"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="394"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="500"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="607"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="753" mass="78064" checksum="B86B6747A9DAF823" modified="2017-10-25" version="1">MINSSVVVADTEEQQSLVEAIAQLLDRHWGPGSAHKLIQDPDRVSEVSLWSQLAEVGVAGLPVPESQGGSGGSWADFAVAAEALGSAVAPTPVIAVAGALGALSAPNVAGGDLSAQIASGRVVPAVAWTEHTGMPAVAGRFEAVAGDHPGRALVSGTAALILTPEADVVLVLAESESGPLLIAVPTSDTDAVRTERTQSLDLLRPLGAVNLRQAAGTVLATGDDAVVAIRRSLVTAGLALAGDLTGVASHCLWAAVDYAATREQFGKPIGAFQAVKHKCADMLAHVELARATAREVAGLLDSGAGAAALDQAVALALLESVTAAQHVTADYIQVLAGVGFTWEHEAHLYYRRAGASAPLFGGVSAARERLDPTRDAAASTVAAEIAPGSPAAELAAAVESLLPLHHEQWGADDSFPARLSWQQRLHQAGWIAPHWPTEFGGRGLSIVDQVACDQVLAGSRAPMLAGVLGVNNVAPTLMHYGTAEQREHLAAIQAGTEVWCQGFSEPGSGSDLASLRTRATLDGDEFVINGQKIWTSEGMEGTHCLLLVRTDPQAPPHKGISALLVPMDTPGITRRPITQITGEGGFAEVFFDDVRVPRSALLGPLHEGWKVTMTTLGFERAGVIMMAGRLEQTVLDLVTTLAGHELPAHARAELTDRLSEARAVGLLGKRALGRIAAGGAPGAEHSVIKLVWSTTMQAIGDTHLRVLGPAAITTATGAAAQHDYLMSRSATIAGGTTEIMRNILAERVLGMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3C9</accession>
    <name>A0A231H3C9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin arsenate reductase</fullName>
            <ecNumber evidence="2">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsC_1</name>
        <name evidence="2" type="ORF">B7C42_04232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43365">
        <property type="protein sequence ID" value="OXR43365"/>
        <property type="gene ID" value="B7C42_04232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="14474" checksum="BFCE9889BBA6F388" modified="2017-10-25" version="1">MKPSVLFVCVHNAGRSQMAQGFLTHLAGDRIDVRSAGTEPADRINPVAAEAMREAGIDITTGAPAVLTPGAVRLSDIVITMGCGDTCPYFPGVDYRDWQLDDPAGRDIDAVRRIRDDIRSRIEDLIAELLPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3F0</accession>
    <name>A0A231H3F0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43413">
        <property type="protein sequence ID" value="OXR43413"/>
        <property type="gene ID" value="B7C42_04280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040701">
        <property type="entry name" value="Bact_RF_family2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18844">
        <property type="entry name" value="baeRF_family2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="348" mass="37126" checksum="DA260915E39D9AA6" modified="2017-10-25" version="1">MTEHPGPFASVYIETVSDTEDAAHQQRLRSRAVREALDGNGADRAVLDAVERGLSDPPPGRAGQAVIADADGVLLTEALPEPPARTTVRLSSMPYLLPLLQLRSPAMAHVVAVVDDRGADLYTVDGDGHRTDHRTEGAQHPVHKAHGGGWAHRSMQSRVEETVRRTIDATAEEVVRLADEAGAGLIVVAGEISARTALVGALASHHRRVVQIDGFTRHTSEDRADLDRRVGEVLQDLARTRVRDVLGEFEQRRAHELAVQGLPGVAAALTERNVETLLIDPAVIGDRAVHVGQDPTAVQASDLPSGRGVVRRADEALPLAALAAGADIVTIDRDPAPTDGVAALLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H415</accession>
    <name>A0A231H415_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KsdD-like steroid dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43594">
        <property type="protein sequence ID" value="OXR43594"/>
        <property type="gene ID" value="B7C42_04462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="UCP036654"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="PTHR43260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="8"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="556" mass="60497" checksum="B6D9F8B062B0AD12" modified="2017-10-25" version="1">MAPSQQPDVIVVGAGLAGLVATYELTRAGRRVLVLDQENRNNLGGQAFWSLGGLFLVDSPEQRRLGIKDSFALAWQDWLGSAGFDRDDEDHWARQWARAYVEFAAGEKRQYLHDLGLRVTPLVGWAERGGATADGHGNSVPRFHLTWGTGPEVLRVFLEPVLAAEQRGLVEFAFRHRVDDLIVEHDAVVGVRGSVLEPSDLDRGVASSRTTVGEFEFRAPAVLVSSGGIGHNHELIRKNWPTERLGPCPQTMISGVPAHVDGRMLEISESAGGRIVNRDRMWHYTEGIHNWDPIWPDHAIRIIPGPSSLWFDANGKRLPAPCFPGFDTNATMKAILDTGYDYSWFVLTQSIIEKEFALSGSEQNPDITGKDLKLTLKSRAAKGAPGPVEAFKRHGVDFVVADTLPELVRGMNEIARGPQLEVAALEHQIVARDRELDNKYSKDAQLMAVANARRSLGDKLGRVAAPHRILDPAHGPLIAVRLNVLTRKTLGGLQTNLDSQVIRSDGDAFPGLYAAGEVAGFGGGGVHGYNALEGTFLGGCIFSGRAAGLALARLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H495</accession>
    <name>A0A231H495_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ECF RNA polymerase sigma factor SigG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sigG_3</name>
        <name evidence="10" type="ORF">B7C42_03919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43684">
        <property type="protein sequence ID" value="OXR43684"/>
        <property type="gene ID" value="B7C42_03919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="156"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="9">
        <location>
            <begin position="229"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="38904" checksum="4E97274E3A67C3B4" modified="2017-10-25" version="1">MKPFTDTDTGRPGNGPVVGARCDDGAMAESSIAAGVDEQTFRELTEPYRAELRTHCYRMLGSMYDAEDALQETLLAAWRGMAEFEQRSSVRTWLYRIATNRCLNFRRAALRRPVAPLPFDAPEPTRHAEVSWLQPCPDALLDPQQVLTARASVELAFIALLQQLPPRQAAVLVLRDVLEFSAAEVADLLGSTPVAVKAALQRARERLSRHEGRRPEPERGSPTERGLSERFARAFEAADVDAVVELLTDEAWLTMPPWPHEYHGRAAIGEFLRGIPAFRDRAEIRLQSVRANAHPAFGCYSRRADGPFRATGLLVTTYGPDGISALAHFPPAENFPRFGLPLALPPEGATIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H499</accession>
    <name>A0A231H499_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acsA_5</name>
        <name evidence="5" type="synonym">acsA</name>
        <name evidence="9" type="ORF">B7C42_04518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43650">
        <property type="protein sequence ID" value="OXR43650"/>
        <property type="gene ID" value="B7C42_04518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="85"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="540"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="394"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="418"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="654" mass="72171" checksum="8BFDC67523D70C4C" modified="2017-10-25" version="1">MTPPNTTQPAVHRFPPSDEFAAQANANTELYHQADADRLEFWAEQARRLDWASEFDQVLDWSEAPFAKWFVGGALNVTYNCVDRHVAAGNGDRVAIHWVGEPGDSRDITYAQLKDEVSKAANYLSGIGLNAGDRVAIYMPMIPEALISMLACARLGLIHSVVFAGFSAGALRSRVDDAQAAVIITADGQYRRGNPVPLKSAVDEALALGNGDHAATSVRKVLVVRRTDHDPDLPWVDGRDVWWHETVDEQSTTHEPRAFDSEHPLFLLYTSGTTGAPKGIVHTSGGYLTQVSYTFHHVFDHKEGRDVFWCGADIGWVTGHSYLVYGPLSNGATEVVYEGTPNFPDEHRHFEIIERYGVTIYYIAPTLVRTFMKWGREIPDAHNLSSVRLLGSVGEPINPEAWKWYREVIGSDTAPIVDTWWQTETGAIMISPLPGVTAAKPGSAMTPLPGISARIVDDRGAPVSAGEQGYLVLDQPWPAMLRGIWGDDERFRETYWSRFAEQGWYFAGDGARYDDDHALWVLGRVDDVMNVSGHRISTAEVESALVGHSWVAEAAVVGAADETTGQGIVAFVILREGVATSGDRLIQELRDRVAREISPIAKPREINVVPELPKTRSGKIMRRLLRDVAEGRDLGDTSTLADPSVFERLRVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4H4</accession>
    <name>A0A231H4H4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43764">
        <property type="protein sequence ID" value="OXR43764"/>
        <property type="gene ID" value="B7C42_03999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="53" mass="5588" checksum="3E69943F24FBFF29" modified="2017-10-25" version="1">MSEPGVVPDREGSGASAPEPSVFRRIGVDWWAVIVAGAFVLLAVADALPKIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4J7</accession>
    <name>A0A231H4J7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gppA_1</name>
        <name evidence="3" type="ORF">B7C42_04010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.40" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43775">
        <property type="protein sequence ID" value="OXR43775"/>
        <property type="gene ID" value="B7C42_04010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008894">
        <property type="term" value="F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="32148" checksum="1E14E9B859B2646A" modified="2017-10-25" version="1">MPMSSTKATLRLSENMDDAGCITPEGAAKLTKTITEFASIAKTSGCVELMPFATSALREAANSDAVLAQIRARAGVDLRVLSGVDEARLTFLAVRRWYGWSAGRILNLDIGGGSLEMSNGCDEAPDAALSLQLGAGRLTRDWLNGDPPGKRRVAVLRDWLDAELVIPAKQLLEVGRPDLAVGTSKTFRSLARLTGAAPSAAGPRVRRSLTSSGLRQLIAFISRMTAADRAELEGVSSDRSQQLVAGALVAEASMRALSLDTLEICPWALREGLILRKLDTDLGTDPGPGSTRPIGVPGPTEAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4P2</accession>
    <name>A0A231H4P2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiol-disulfide oxidoreductase ResA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">resA</name>
        <name evidence="7" type="ORF">B7C42_04035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43800">
        <property type="protein sequence ID" value="OXR43800"/>
        <property type="gene ID" value="B7C42_04035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011266098" evidence="5">
        <location>
            <begin position="34"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="54"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="21597" checksum="A097936ACA55CA7B" modified="2017-10-25" version="1">MSGAVRRLLPMLLACVAVVAALAGCSSGNDAVAQGGTFDFVSPGGKTDIRYDPPAARGTIGHLSGPNLLTGKTVSVDDFPNQVVVLNLWGQWCGPCRAEAPALEQVYEQSKDKGVAFLGINVRDPQQDKARDFVTDNHVGYPSIYDPEMRSLLALGGKFPTSVIPTTLVLDRQHRVAAVFLRSLLAEDLLPVVNQVAQEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H578</accession>
    <name>A0A231H578_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036505726.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43942">
        <property type="protein sequence ID" value="OXR43942"/>
        <property type="gene ID" value="B7C42_04181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="145" mass="15644" checksum="52E9AAF768EEF1B5" modified="2017-10-25" version="1">MSQNRIRPRPTVPDIVALFHDDDQAGELFMRTDEVIAVPAGQFVAMARAVAQLADRALVGGGIHADRPDEGTLGAFGDAGENSVTEPEPVTRGLYVDADGDVWEHDELGWRLLLQAGVVVDPVSHWDWILGHVGEFGPFTFVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5D4</accession>
    <name>A0A231H5D4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR43992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783863.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43992">
        <property type="protein sequence ID" value="OXR43992"/>
        <property type="gene ID" value="B7C42_03548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="34791" checksum="FAF8134034D40AD7" modified="2017-10-25" version="1">MIVDWQTYYDAAKKCQDLAAELRKADKPVHEAVKGDCKGMAGDANGCKQWGEAYDKSALHTLQASASLANALTNYGAVLYAHGYNWGIANKSNPPPPRPDIRQVGEYTVDLSGSSSVPADGGRGFDDHGGVKAFFDKLVVAVLNKFHKLPNGNAAKLDKAHTTWNTFATHQTVTGASASIAAISGLFDGMDDAAHRQQLQEHFTTLKSSADNVVTGAQNISAPTGQYHAATVSFGHETANKINWLEAGVAAAAVAGVALAIFTVGMSVEAAGEGITAAVAATIGAIEEAFSSSALVEILGVTTLAIGAVATVKAFEAVPVDDLEKMPPNSLPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5U2</accession>
    <name>A0A231H5U2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">murC</name>
        <name evidence="15" type="ORF">B7C42_03690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44132">
        <property type="protein sequence ID" value="OXR44132"/>
        <property type="gene ID" value="B7C42_03690"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="140"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="355"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="142"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR44132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="515" mass="53911" checksum="927606AAF1769B4C" modified="2017-10-25" version="1">MTGGNETAEVGAADPVNQTGQAFAELPELLRRVHMVGIGGAGMSGIARILLARGGEVSGSDAKESRGVLALRARGAQVRIGHDASALDLLEGGPSAVVTTYAAIPKTNPELVEANRRGVPVLMRPTVLAELMRGHHTLLVSGTHGKTSTTSMLVVALQHCGFDPSFAVGGELNEAGTNAHHGTGGYFVAEADESDGSLLQYDPDVAVVTNIESDHLDFFGSDEAYVQVFDDFVARLVSGGLLVVCLDDPGSLALARRVADRVAAGELDIRVAGYGSTETADAPVPMQARLVSWEPRDVGGVATVQLGDEPAPRTLRLSVPGRHMALNALAAVLAARDAGAEVDEILQGLEGFGGVHRRFQFVGRENGVRVFDDYAHHPTEVRAVLGAAAELVRQEAADGARSRQGRVIVVFQPHLYSRTATFAEEFGAALSLADEVVVLDVYGAREKPLPGVNGALVAQAVTKPVHYQPDMSRVGRQAASLARAGDVVITMGAGDVTMLGGQILDGLRVRPSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6A0</accession>
    <name>A0A231H6A0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hicd</name>
        <name evidence="3" type="ORF">B7C42_03797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44236">
        <property type="protein sequence ID" value="OXR44236"/>
        <property type="gene ID" value="B7C42_03797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="2">
        <location>
            <begin position="8"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="37450" checksum="5CD5FE97A1104E73" modified="2017-10-25" version="1">MDSRRVVRLGLIEGDGIGPEVVQATRAVVDEALAAAGAATPEWVELPIGHAAIAECGEPLPETTLSALADLDAWILGPHDNVSYAPHHRIGAPPGGAIRKRFGLYANIRPARTFPGVRAAATDIDLVIVRENSEGFYADRNMFAGSGEFRPTADVAMAVAVITRAACERIAHQACALAAARSGRLTIVHKANVLPMTMGLFRDVCWEVAAGYSGVEVNDEHVDAAAAHLVRAPGDYDVLVTENLFGDILSDLAGELAGSLGLAASLNCSADKAMAQAVHGAAPALAGRNRANPGALQLSAAMLLRWLGTRDGDPALLGAGDRIERAVAATLAAGIATADLGGLASTSEFTEQVRARVHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7C7</accession>
    <name>A0A231H7C7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase CzcO</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">czcO_2</name>
        <name evidence="6" type="ORF">B7C42_03486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44692">
        <property type="protein sequence ID" value="OXR44692"/>
        <property type="gene ID" value="B7C42_03486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="446" mass="47274" checksum="55AB6E049C5AB95E" modified="2017-10-25" version="1">MTAVTAPDFEIVVIGAGQAGLSVGYHLRRLGLTPGVDFVIVDHAPGPGGAWQFRWPSLTLSTVNRVHDLPGMSFTETLPAGSDSVPAATAVPHYFELYEKRFDLQVRRPVSVRVVCDRATTATCPGTLVDGLLHVETAAGENRSAAGVSVVRPPVTGDDGLPSTAREASTAAEPGGSTPRDAFTDPGSPDEPSAAADSRRSTDAPTGSPGATGETLRVRGVINATGTWEKPFIPYYPGAETFAGRQLHAHDYRSAAEFAGKHVVVVGAGISAVQLLDEISQVTSTTWVSRTEPRWREGPFGPDEGRRAVAMVEDRVRRGLPPRSVVSVTGLPVDDRIRAARARGALTWHPMFARIEPEGVRWVDGSFRPVDVILWATGFRSALDHLAPLRLRGPGGGITMTGRLATQVATDPRIHLIGYGPSASTIGANRAGRAAAVELTRYLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7T0</accession>
    <name>A0A231H7T0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45073">
        <property type="protein sequence ID" value="OXR45073"/>
        <property type="gene ID" value="B7C42_03030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="397" mass="43101" checksum="57667754CD56E944" modified="2017-10-25" version="1">MSTVFRRRISPTERMYFPMRDMAPPFLMQLAIPGTGALDAERLRRAVAVAAAACPGARLRREGKYWVDTGVPPAVREVPGHIVHYDRLEADPVLASAISPTPETTCEVLVLTGDPVTVIFRVFHGVMDGMGMVLWARNVLAALRGEQPEELRDPVADRELVRRLGAPGRPTAMIPRFRSAVGHGPQEVGSPRHLLRHRSIAATGSGAVARVSALLADAAGSTQRIMVPVDLRRHDAQLRSTANLALPLFLDIRPGQDWRQVRDGMRAALRERTELNQLAASAIANAPHAVGRTILRTTNALGARFGRNLASATVSHMGRFDLGELAVPGWSPKSVRVLPQHSVAMPLLFAMVEAGGRTELTVSARNGHGIENRLEALLDRIAATLESELPQRDSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8B0</accession>
    <name>A0A231H8B0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776754.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45253">
        <property type="protein sequence ID" value="OXR45253"/>
        <property type="gene ID" value="B7C42_02378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="102" mass="11478" checksum="B8863A16DA2CCB3B" modified="2017-10-25" version="1">MAGVEITDRFVRRTLDNGRIEEVTWLELTEVRIITTADGPFADDVFFVLIGVRGNGCVVPHSAADTEFLARLQKLPGFDNAAVIEAMETVGDRQFLVWRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8G4</accession>
    <name>A0A231H8G4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3 9">2.7.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apbE_1</name>
        <name evidence="10" type="ORF">B7C42_03085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3 9"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780059.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45128">
        <property type="protein sequence ID" value="OXR45128"/>
        <property type="gene ID" value="B7C42_03085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="34227" checksum="05ECCC036F64D0CB" modified="2017-10-25" version="1">MSTARGAAVASETFRAIGTSVVVVCTDARELARAADLVRARLDDLDRAASRFRADSELAVINSRSAESARAGRSEQLRIPVGTTLGSCLRAAMRTQRLTSGLVSASLGAALIACGYDDDLDAVRARGDVGPPAPDRISIPLRHMIFDEQRGEVALRPGTALDLGASAKAWAADTIAAELAATGPGGYLVNLGGDIAVAGTGPPRGWSIGVRDWNDAVVQVVTSTGQAFATSSTRLRTWVRGGIRRHHIIDPRTGRSARTRWAQVTCAGPDAVQANAASTAAIILDDQAPRWLTDRGVPACLMTVDHEVVTTPGWPAPTAARKRHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8L1</accession>
    <name>A0A231H8L1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CaMKII_AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45185">
        <property type="protein sequence ID" value="OXR45185"/>
        <property type="gene ID" value="B7C42_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CaMKII_AD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="8317" checksum="03B5EA129D0B5436" modified="2017-10-25" version="1">MANSFATVLANSTVTDDIGDIRFLGADHAVVVSKAAILFAGETEVPADRYVNATWVMHRRDGKWTVAAYHNSPAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8X8</accession>
    <name>A0A231H8X8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uppP_2</name>
        <name evidence="14" type="synonym">uppP</name>
        <name evidence="15" type="ORF">B7C42_02311</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45186">
        <property type="protein sequence ID" value="OXR45186"/>
        <property type="gene ID" value="B7C42_02311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR45186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="312" mass="33585" checksum="A7304940C1C7FEA7" modified="2017-10-25" version="1">MLTYFQAMVIGAVQGFTELFPISSLGHSVLVAAWLGGRWGALPGRGGTESAATYLAFVVALHVATAVALVIYYWRDWCAIAAGFVEMVRTRRLDTVPQRLAWLIVIATVPVAILGPLLEHPLHDVFAAPLCAAAFLTVNGVVLVVGEGLRRRNEPTLAEYGRRFALNQANSRMRTATTLSLPQSDRRLAALDSRDAVGIGLAQAGALLTGFSRAGLTMVGGLWRGLEHEHAAKFAFLLATPAIFGAGLVDLPDLITPRAEVIWGPIVVGAVVSGVTSWLAVRYLERYFRTRTLLPFAAYCVIVGVVSIFRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H904</accession>
    <name>A0A231H904_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glpD2</name>
        <name evidence="10" type="ORF">B7C42_02407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776736.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45282">
        <property type="protein sequence ID" value="OXR45282"/>
        <property type="gene ID" value="B7C42_02407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="8">
        <location>
            <begin position="31"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="9">
        <location>
            <begin position="408"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="582" mass="63616" checksum="D4B51162391EF59A" modified="2017-10-25" version="1">MNEKSHGQHTGELGPEQRAATWESLGAKHFDVIVIGGGVVGAGIALDAATRGLEVALVEARDLASGTSSRSSKMFHGGLRYLEQLEFGLVREALRERELSLKTLAPHLVKPLRFLYPLTHRGWERPYVASGLVLYDTMGGAKSVPGQHHVTRSGALRLAPGVRRDALIGGVTYYDTVVDDARHTMTVARTAAHYGAVIRTSTQVVDFLREADRVVGVKVRDSEDGRTTEVRGHVVINATGVWTDELQALSHVRGRFHVRASKGVHIVVPRDRIASDAALILRTQTSVLFVIPWGSNHWIIGTTDTDWNLDLAHPAATKADIDYLLERINEVLVTPLTHDDIQGVYAGLRPLLAGESDETSKLSREHAVAQIAPGLVAIAGGKYTTYRVMAYDAVDLAVHDIPQRVSSSITDKVPLLGADGYFALLNQTPQLAQTYGVHPYRIEHLLNRYGSLITDVLDLAEGKPELLQPITDAPGYLRVEAVYAAVAEGALHLDDILARRTRISIEFSHRGIECADEVARLVAPVLGWDEEQIRREVSTYNARVDAEIRSQTQPDDISADALRAAAPEPRPEILEPVPLPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9K4</accession>
    <name>A0A231H9K4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45416">
        <property type="protein sequence ID" value="OXR45416"/>
        <property type="gene ID" value="B7C42_02541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="457" mass="46100" checksum="34AA72EC54BA2DB1" modified="2017-10-25" version="1">MRRPTALRRRPTAARNDTTTPATTSDPSVDPPIVATLVRPLLDLRAALGTGVATPAATITGALSSASTQAADTEGPHRDGVHALESTWTGPGSDAAVPALRTTQTQIGDISDRGPAYLGVLADAHATSARAADRMDRIIADFRRDARTILGNATAAPDTDAVINRATQALRDAITTVTSARTEMDDHSRRLDEMGPLTVTTPAGLNSAQSWGDTPATVLPSAYGAVPGQYGAVPAQYGTAPGQPIDPAQLAQLQLQQLLVQAGVQVGTSAINAGVDIGTHLIDKIAEVGTHTIDTVASSVDQAIPQLINPDHATADKTNPAGHSGDSAKLFDFGPGKTAPGTTGPGSIIPGAPAPDKAPADKSPADKSDPPPPSPSSILPPPADPPPMPKPPAPTPAPAPAPEPAHPGGVAGGMALPPPAGSGQDHKPRDGQLGVTVPAAETTVPAAVIGDFGDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAE8</accession>
    <name>A0A231HAE8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enoyl-CoA hydratase echA8</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">echA8_5</name>
        <name evidence="1" type="ORF">B7C42_02113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45821">
        <property type="protein sequence ID" value="OXR45821"/>
        <property type="gene ID" value="B7C42_02113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="27882" checksum="14246D8C50D063FB" modified="2017-10-25" version="1">MTEPVVTVEHADGVATVTLHRPAVRNALNRALMDAVWDAVAAAGANSDVGAVVLTGADPAFCAGIDIGAAASGPAPVRSPGSGPGRGPDGLFRFLPVIDIPVIGAINGACVAGGLELALQCTFLVASERARFADTHARMGMMPGGGVTVGLTRTVGWRRAVELSLTGNFLTAEDALAYGLVNHVVPHENLLPFTRTLAADLLAGDSEARTRLLRHYRALAEEDGRRAQLLEGVMAETWSPGTARMAEYGARVIERGREQMRERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAZ1</accession>
    <name>A0A231HAZ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase-like protein YjlD</fullName>
            <ecNumber evidence="3">1.6.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjlD_1</name>
        <name evidence="3" type="ORF">B7C42_00984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46021">
        <property type="protein sequence ID" value="OXR46021"/>
        <property type="gene ID" value="B7C42_00984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="38143" checksum="61691389597AA620" modified="2017-10-25" version="1">MSAHQIASHRILVLGAGYAGLAAAGRLCKSRGAQITVVDSRAEMVERVRLHQLAAGQTIERRDLRTMLERKGAHFVRGRVAAIDTAAQEVSLSDGSVLGYDTLVYTLGSAADVDSVAGVREYAHPVATLENIAALPPLRGRVAVVGAGATGIETAAELAESHPELPVALVSSERPGFWLSDRAQRHIAATLERLGVEVHAGAKVVEVAADGVRLAGGGRIEAETVLWTTGFTTSDLAARAGLAVDARGRVLVDATLRTSDPHVYAAGDCAAIAGPGGRELRMACATALPTGSHAARAALARMRGAEPDELRFRYLLQCISLGRRDAVVQFVRADDAPTPRALTGRPAAVVKEMIVRGAAMQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB25</accession>
    <name>A0A231HB25_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="8">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hemH</name>
        <name evidence="8" type="synonym">cpfC</name>
        <name evidence="10" type="ORF">B7C42_02220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45927">
        <property type="protein sequence ID" value="OXR45927"/>
        <property type="gene ID" value="B7C42_02220"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR45927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="37777" checksum="FC38061E5E0D6B32" modified="2017-10-25" version="1">MTGTVDALLLLSFGGPERPEDVMPFLENVTRGRGVPRERLDEVAQHYLHFGGVSPINALNRELIAAIEAEFAVRAVDLPVYFGNRNWHPMIEETVATMRADGIGHALVFPTSAWGGYSGCRQYDEDIERARAAVDGAPELTKLRQYFDHPLLIDSFADAVRAAVRELPADSRERARLVFTAHSIPVAADVAAGPPADGGHLYSRQVAEAARLCAAATGFDDFDVVWQSRSGPPQVPWLDPDIVDHLEALSGKGVEAVVVCPVGFVSDHLEVVWDLDNEAAEKAAELGMAFARAATPGPDPRFARMVAELVGEHLHGNEPRRSGTVPGYGCTRNGAICAPGCCEPVRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB63</accession>
    <name>A0A231HB63_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rkpK</name>
        <name evidence="12" type="ORF">B7C42_01148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783309.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46183">
        <property type="protein sequence ID" value="OXR46183"/>
        <property type="gene ID" value="B7C42_01148"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="323"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR46183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="440" mass="47152" checksum="69C2D036CB50D218" modified="2017-10-25" version="1">MRLTVFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSDGVVPFYEPGLEAVLRRNLDAGRLRFTTSYEEAAAHADAHFLGVGTPQKKGEYGADLKYVHAVADSLAPLLERPSVLIGKSTVPVGTAAELGRRMRARAHTDVEVAWNPEFLREGFAVRDTLRPDRLVLGVDGERERADWVRAQVREIYADLIAAQVPFLLTDLATAELVKVSANAFLATKISFINAVSEVCEATGADVTMLADALGHDARIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGADHAVAFLREVDNINMRRRTKVVDMAAKACGGSLLGANVAVLGAAFKPESDDVRDSPALNVAGMIQLHGAVVTVYDPKALENSRRVFPTLNYATSVAEACDRADVVLVLTEWDEFTALSPRDLEPVVRGRSIIDGRNCLERAAWTAAGWVYAGLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB90</accession>
    <name>A0A231HB90_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_5</name>
        <name evidence="5" type="ORF">B7C42_02280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042413.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45987">
        <property type="protein sequence ID" value="OXR45987"/>
        <property type="gene ID" value="B7C42_02280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="23200" checksum="C27A192A335B387A" modified="2017-10-25" version="1">MRTGQDSADNDTRIWGGTTLTERREARRTALLEAALDLIGEAGAGAVTMRAVCRRAGLTDRYFYESFTGRDDLLDVLYRQVADDFREPMTSFAAAADPDRDRELARVLVDKVLADPRKSRLFLVEPYSSTGLGQTTIAVMPTFTRLIQDHLFTDIDDPMRRRMAAVTMASGNAGLFAAWLNGSLRADRDQVVDHLVAVIGAYRSMYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBB1</accession>
    <name>A0A231HBB1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46125">
        <property type="protein sequence ID" value="OXR46125"/>
        <property type="gene ID" value="B7C42_01090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="37318" checksum="8A7C2FF71FC80C12" modified="2017-10-25" version="1">MSATRRLLDLLAYLQTGRRYTGAELAARLETSPRTVRRDVERLREYGYPVITQPGPGGFYQLTAGRILPPLVFDDDEAVATVVALGMLAATSEPQGQSEPQRQSEPQRQSDIGAAALRAFGKIDQLLPKRLRGRANAVRATVETAAVAAPAVDAAVLALVARAAADHEHLVFDYRTRTGVIARRRVEPYRQVYQHLRWYLLAWDRDRGDWRTFRLDRMADIAATATFFEPRPLPAETAAGYLRRELTAGRHRAVVTVAAPAASVADILKFQNCDIESRGPRRCRITTWVDSFEWLVLNLAFLDADFVIEEPPAFRDRSRALAARLDRAADAAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBF3</accession>
    <name>A0A231HBF3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaJ1</name>
        <name evidence="6" type="synonym">dnaJ</name>
        <name evidence="10" type="ORF">B7C42_01107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781459.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46142">
        <property type="protein sequence ID" value="OXR46142"/>
        <property type="gene ID" value="B7C42_01107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="212"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="226"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="40829" checksum="5E1AD77EBBF1625D" modified="2017-10-25" version="1">MNREWLEKDFYKELGISSGATQDEIKKAYRKLARDLHPDKNPGDTKAEERFKAVSEAHAVLADPEKRKEYDEARRLFASGGFGRGGYAPGGGYAGGGGFSNEFNLGDIFGGAAAGAGDGGLGDILGGLFNRGGTRTTSRPRRGSDVETETTLGFREAAQGVTVPLRMTSPSPCTTCHGSGAKPGTSPRVCPHCNGTGVISRNQGAFGFSEPCDDCRGTGSIIDDPCTDCHGTGIQNRTRTITVRIPPGVRDGQRIRLAGQGEAGLRGAPAGDLYVTVHVSQDKVFGRNGDDLTLVLPVSYSELVLGTTVSVPTLEGRVGVKVPPGTADGRTLRVRGRGVPKRGGGAGDLLVTVKVAVPQKLDDEASEALRRYAEAEKAGGFDPRAGWAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBJ1</accession>
    <name>A0A231HBJ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadA_2</name>
        <name evidence="6" type="ORF">B7C42_01279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781604.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46313">
        <property type="protein sequence ID" value="OXR46313"/>
        <property type="gene ID" value="B7C42_01279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="267"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="40395" checksum="E10D5EE0D0A94A6D" modified="2017-10-25" version="1">MRDAVIVEAVRTPIGKGKATGALHDQHPVDLFAHSLREVVRRSGIDPVLIDDVIGGVVTQIGEQSVNITRRAALAAGYPESVPATTVDRQCGSSQQAIHFAAQGVLAGAYDIVVAGGLESMSRVPMGSSVAGATDINGVAFAERYPDELVPQGISAELIAARWGISRTAMDEFSLASHEKAAAATKNGSFEAQLAPLAGLSTDEGIRVGSTLETLAGLRPAYYSEAYAARFPEIGWNVTAANASQINDGSAAVLIMTSEKAAQLGLRPLARLHSFAVAGDDPLLMLTAVIPATRKVLQRSGLSPADIDLFEVNEAFASVVLAWAADTGADLSRVNVNGGAIALGHPLGASGARLATTLVHALHERGARFGLQTMCEAGGLANATIYERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBV4</accession>
    <name>A0A231HBV4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0060 membrane protein B7C42_01265</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0060 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781594.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46299">
        <property type="protein sequence ID" value="OXR46299"/>
        <property type="gene ID" value="B7C42_01265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="110" mass="11689" checksum="FC813728330ABA42" modified="2017-10-25" version="1">MTVVRSILLFVLAALAEIGGAWLVWQGVREHRGWAWMGAGVIALGLYGFVATLQPDAHFGRILAAYGGVFVAGSLLWGVAFDGFRPDRWDVAGAAVCLLGVAVIMYAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBY2</accession>
    <name>A0A231HBY2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redox-sensitive transcriptional activator SoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soxR_1</name>
        <name evidence="2" type="ORF">B7C42_01298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46332">
        <property type="protein sequence ID" value="OXR46332"/>
        <property type="gene ID" value="B7C42_01298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="13493" checksum="4656B8A31550B015" modified="2017-10-25" version="1">MRIGELARRTGVSVRSLRYYETQGLLASTRTSGGQREYREQAVDRVVRIQEMFAAGLHSRTIAELLPCINDTDGTPARTATPWLSETLTAERERIDACIKDLVRTREVLDGVISAAHGEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBZ8</accession>
    <name>A0A231HBZ8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MecA_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781622.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46276">
        <property type="protein sequence ID" value="OXR46276"/>
        <property type="gene ID" value="B7C42_01242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MecA_N" evidence="1">
        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="560" mass="58788" checksum="8E261403BE365478" modified="2017-10-25" version="1">MDVWGSRRFRVRGAVALAAIAAVAIVMGSCDFHSTPSGPEGVVEHFTQLMDDRDAAGAAALTSYPSGAESTLKSMFDGLQPGKPDYKLVQFISLDGDSAMFNLKAAWNFGPGKDWSYDLQGNIRKLAIGWRISWDPTVVMPQLDSKRSVKLVRTEATPPPKVNDNDGQPLLTQQTINVIKVDPTKTGDPVGTTNALADAIAPVAPLITGASLMQQLAGSQGKPITAVSLREDDFAILEPRMASIPGVVMEKQPRLIVADRRVWSPMTEALQKVWQENRDQHAGWGVQLFEPDGRMVTQLAGYQGPPGPDIASTMDQKLQRAAEDAVVSVGTAASIVAIQPSTGAVVAAAQNNYASAQGAPAFTATYPVGGAMDLFKAVASIQKKKAPQDVSVQDAAEAAAMLGVGIGFKVPGLDETTGRLPIGGRGVEQVKQGANDPILASPFGMAIAAATIARGSVAPPMIEIGRPGTTEAKLEPLPGDVVDKLRGMLRDATGSPQEVTVSRYAGVTAFTANAGSDGWLIANAGDLAFAIHIDDVDSGDATSRMAARMLQSLATPDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC08</accession>
    <name>A0A231HC08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anti-sigma-L factor RslA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rslA</name>
        <name evidence="4" type="ORF">B7C42_01252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46286">
        <property type="protein sequence ID" value="OXR46286"/>
        <property type="gene ID" value="B7C42_01252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="304" mass="32004" checksum="27A273C1C1C8B733" modified="2017-10-25" version="1">MTADTASHDDYATWDAPYLLGALDRDQRLEYEAHLADCDECRLAVADLSGLPGLLSHVPDDVALSLLDDETAADHAGSFGDAGFDALLNRVRASEATTDGAGMLPFESHPATGPAAESGTAEPDRAAETPAVRETPPEAGRAEPGEAPASLAAARERKRSRSGPWLALAGAVAAAAAAVAITIPITVAHTEHNNPPTAEQVVTERQMDQVIPSPITANFTLTQLRSGTRVNMSCNYAPSDTDYTWDGALWVVHTDGTQSMVAQWTAHPGQTVTADGITSAPPDQIRSVEIRSTTTNQVFLRGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCA7</accession>
    <name>A0A231HCA7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043455.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46396">
        <property type="protein sequence ID" value="OXR46396"/>
        <property type="gene ID" value="B7C42_01362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="205" mass="22428" checksum="EDE84D6ACBD2362E" modified="2017-10-25" version="1">MTESPDRRPDIAERRSEPAVRITDHERAQVERLLQLALRDGSLDLAELDRRLAAAYAATTHDELAAVTADLPVAATREPLVLTTVSGSLRKDGQWIVPAEITATAASGSVRLDFTEAICPHAVVELHVGIASGSVRLTVPRGWQVDVDRVAFVSGSAKNRVNEPPLPGCPTLRVDGSITSGSLRAEYPKPPRRGFWAWLFRRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCE6</accession>
    <name>A0A231HCE6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb_1</name>
        <name evidence="6" type="ORF">B7C42_01303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036507149.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46337">
        <property type="protein sequence ID" value="OXR46337"/>
        <property type="gene ID" value="B7C42_01303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="179" mass="18387" checksum="B137D45DE337CEA4" modified="2017-10-25" version="1">MAGDTVITVIGNLTADPELRFTPAGAAVANFTVASTPRVFDRNANEWKDGEALFLRCNIWREAAENVAESLTRGARVIVSGRLKQRSYETREGEKRTVVELEVDEVGPSLRYATAKVNKTSRGGGGGGFGGNSGGSGGGFGGSNGGSRGGQSSAGDDPWGSAPAAGSFGGGQMDDEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD61</accession>
    <name>A0A231HD61_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dibenzothiophene desulfurization enzyme C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soxC_1</name>
        <name evidence="2" type="ORF">B7C42_00027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46913">
        <property type="protein sequence ID" value="OXR46913"/>
        <property type="gene ID" value="B7C42_00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="1">
        <location>
            <begin position="242"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="43943" checksum="E2110DD2455EE7CA" modified="2017-10-25" version="1">MTSTQTEHIPPALDSAELQAVIDEIAADARRRRDAGGGRPDRALALAREHRLGAVRLPRELGGAGYSLREFFALAVRLAQADPDVPHILRIHWATAEEALRVRDTDRGERWLQWIRESKIFAGAQSELSGQPGVYTYDTTVTAEGDHFRLNGRKFYSTGSIYADYLRIGANNEAGEQVSIIVPGDREGVVHVDDWDGIGQRETGSGTTILDNVLVHSDEIGEFRLLPGPGRPRGPLAHLLLHAIAAGILRALTEDTATLLRERTRSYSWGNAELARNDPQLLAVVGSLSSTAFVVEAAVLAAADALDAATRHVWEHGVPDDRLELAASLQTSQVKVAVEKIALRAAAEAFDAGGASWTRASVRLDRHWRNLRTLFSHNPTVYKARVVGDVVVNDAELPSVGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD96</accession>
    <name>A0A231HD96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46901">
        <property type="protein sequence ID" value="OXR46901"/>
        <property type="gene ID" value="B7C42_00015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046193">
        <property type="entry name" value="DUF6221"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19730">
        <property type="entry name" value="DUF6221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="8499" checksum="F24E8F9B6FEA1E8A" modified="2017-10-25" version="1">MGSIIEFIDARLREDEYAARAVDGERRAWREVLAKRLIVTLAQLPDGGGSEDRLLRCVALCWADHADYRPEWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDV0</accession>
    <name>A0A231HDV0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47002">
        <property type="protein sequence ID" value="OXR47002"/>
        <property type="gene ID" value="B7C42_00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="221" mass="22702" checksum="4E2F5901D5B17D65" modified="2017-10-25" version="1">MPVVFSEVVEAVELVLGAAGRVVRSTMRLHSDDCTPQYVLRVSLCGVTEIEETISEMYARIIALLALKGGEHCHANPDHLPFIAGRIALTVEAALQASISSHAVWVDLCEKCEQPLEVVLDVRPASSESVSEFSGGLGGSGGWFGAGGGGGGVGLLNGGAGGEGADGALLIFQIAEDNSLLDIDAFVTTGSFLWTRRPDVDRIEVVAIGGGGGGASGGRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDZ7</accession>
    <name>A0A231HDZ7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">valS</name>
        <name evidence="14" type="ORF">B7C42_00283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47161">
        <property type="protein sequence ID" value="OXR47161"/>
        <property type="gene ID" value="B7C42_00283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="29"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="449"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="626"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="13">
        <location>
            <begin position="829"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR47161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="900" mass="100055" checksum="151A7775A1C7D11D" modified="2017-10-25" version="1">MTSAAPDNSRNRADALPKSWNPSDVEADLYERWVAAGYFTADPASDKPPYSIVLPPPNVTGNLHMGHAFDHTLMDLLTRRKRMQGYEVLWLPGMDHAGIATQTVVEKQLAVDGKTKEDFGRELFVDKVWDWKRESGGAIQGQMRRLGDGVDWSRDRFTMDEGLSRAVQTIFKRLYDAGLIYRAERLVNWSPSLETAISDVEVKYEDVEGELVSLRYGSLNDDEPHVIVATTRVETMLGDTAVAVHPEDERYKALIGTTVHHPITGRQIPIVADDYVDPEFGSGAVKITPAHDPNDFEIGLRHNLPMPTIMDKTGKIADTGTEFDGMDRFEARVKIRERLADEGRIVAEKRPYVHSVGHSERSGEPIEPRLSMQWWVKVESLAKAAGDAVRNGAVTIYPASQEPRWFEWVDNMHDWCISRQLWWGHRIPIWYGPEGEIACVGPDEQAPEGWVQDPDVLDTWFSSGLWPFSTMGWPDATPELSKFYPTSVLVTGYDILFFWVARMMMFGMFVSDDPVIAAGKDSGRQQVPFDDVFLHGLIRDEFGRKYSKSKGIGVDPLLWIDEYGADATRFTLARGAQPGSDLSVGPPHVQASRNFITKLFNASKFALMNGAAPGDLPERAGLTDTDRWILDRLDEVRAEVDGAFDRYEFGKACEALYHFAWDKLCDWYLELAKVQFAESEERAASTRIVLGNVLDSVLRLLHPAIPFVTETLWQALTEAGADDSLVIAAWPQPSGVATDTVAAQRIADLQKLVTEIRRFRSDQGLTDKQKVAAKLIGIDTADLTGLHAEIASLARLTEPDADFSATAAVEVRLSGATVTVELDTSGTVDLDAERRRLEKDLAAAQKDLAATTAKLGNEAFLAKAPDEVVAKIRTRREVAESEVTRIGARLAQIAESVANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDZ9</accession>
    <name>A0A231HDZ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46998">
        <property type="protein sequence ID" value="OXR46998"/>
        <property type="gene ID" value="B7C42_00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="14045" checksum="F65E3A2A3921BF81" modified="2017-10-25" version="1">MLKRLQADPRYRRMCAVKVLREVGGTVVEVSDEMPLVFPGRGDVLRDPHNFNRTWRAARGTVYKDVTQYTFRKTVATLIAEMADSKTAAKQLGHSRDGITERHYIASPERAPDSSAVLEAGLGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE13</accession>
    <name>A0A231HE13_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase-associated protein RapA</fullName>
            <ecNumber evidence="3">3.6.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rapA_1</name>
        <name evidence="3" type="ORF">B7C42_00246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47124">
        <property type="protein sequence ID" value="OXR47124"/>
        <property type="gene ID" value="B7C42_00246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="DUF3883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="124"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="517"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1188" mass="135137" checksum="2DF25A7E64516688" modified="2017-10-25" version="1">MSETTETTVSLATLRTGQRLRGLVPGQTVTLIAVDPIDSALYEIFYRDDAGRSGARTLTEADTVRLELAGDFDAAPAFDGDPDEFRLAAEALRIKYAALYDPMVAVNSSDVDPLPHQIRAVYEELLPRIPLRFLLADDPGAGKTIMAGLYIKELILRSDCERAIVVAPGGLVEQWREELSQKFDLHFEVFGRQMVDDAQGRNVFTRHPYLIVRMDQLSRSDDLMEQLSDVTWDVAVVDEAHRMSARYSSWAGEVDETKRFRLGRLLSETAHNFLLMTATPHAGKEEDFQLFMSLLDRDRFEGQFRQGVHRTDTRGLMRRMVKEDLLTFEGKPLFPERRAYTVEYELSAAERELYELVTAYVRTEMGRAERIAQAGDKKRGNNVGFALTVLQRRLASSPEAILRSLDRRQQRLEGRLREMRRAQDAARYTTGPTYPSQTDTELPAMAIEDFEDFDEEATEEERAQFEAQVDQVVDLATAAQTIPELQAEISILEDLIRVARRVRLQDDDKKWVQLRTILDEQVLAHDGAGAARKIIIFTEHRDTLDYLNQKISARLGRADSVITIHGGIRREERKAAREKFTYSPETVVLLATDAAGEGLNLQRAHLMVNYDLPWNPNRIEQRFGRIHRIGQREVCHLWNMVAKDTREGDVFVRLLSKIAQMSMAYNGNLFNVLGDADAFQERSLRDLLIEAIRYGDQPETKARLDRIIDAGVSHGLDEMVAERALHPEMFSALDLDEVRARMEKARERRLQPGYIAAFFLPAFERLGGRIRKREKGRYEVTRVPTRVIDTARRLNRWAQVADQYERVTFELHLTRPTGQTTAALIAPGHPLLHAVIEATIEDLGAVLKRGTTLVDRREKQTDAPMLMYAVEQRIENAAPGAHTVSHHFDYPLLEQTGTVTVSAAPPYLDYDAPDPHEADAITAIAASDWARKNHEKAVRAWSFRDGLQPRMDEIKARLDIETSRTRKQVKDRLLAEINHWDREYTRLEALERAGTIGRLRAETAYARARQLDERLDHRLRELDEAAQLVAVPAIIRGTALVIPSSVIADEAHHQPQIFARDTDEAERRAVAAVLDAERSLGRTPIEMPRNNPGYDIQSIDSDGRIHYIEVKGRVVGSDTFTITANEVTFAQTQVDRHRLALVLVSPEGAEHDELRYIINAFTHLEPSATTRSYNEKWRDYWFRGGPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE15</accession>
    <name>A0A231HE15_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ctaE_1</name>
        <name evidence="10" type="ORF">B7C42_00063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46947">
        <property type="protein sequence ID" value="OXR46947"/>
        <property type="gene ID" value="B7C42_00063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21923" checksum="8CF4B5C37900CF11" modified="2017-10-25" version="1">MRDTIATWGRTGRGRRLPAEAGVWVFIGGDLIVFGFLFVVYLGYRAKDPDLFARSQRALSVDAGAVNTLVLLTSSLLVVLAVRAIRAADPRVAPRLVLGAMTCGIVFATVKAFEYDHAIGHHHTPTGNDFFLFYFLLTGLHLFHVVLGLGVLTFLWSLALRAHRLSPLGISFAEGCACFWHVVDLLWIIIFPLVYLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEB9</accession>
    <name>A0A231HEB9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG3_2</name>
        <name evidence="1" type="ORF">B7C42_00321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47199">
        <property type="protein sequence ID" value="OXR47199"/>
        <property type="gene ID" value="B7C42_00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="243" mass="25288" checksum="9E9BB1D304C2F554" modified="2017-10-25" version="1">MGRIDGKTVVVTGAARGMGAAFAQRLVSEGASVVITDVLTEEGKRTAARLGDAALFVPHDVTDESAWNDVVVQAESAFGPVSGLVNNAGIVHVDPIETLAEADYRKVIDVNQVGVFLGMKAVVGSMRRAGGGSIVNISSVGGIIGFSNILGYTASKWAVRGMTKTAAQEFGPMGIRVNSVHPGVVMTEMTSDSARSNSMFHDQPLARPGTPEELANLVLFLISDESGYSTGSEFVADGGFTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEN6</accession>
    <name>A0A231HEN6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">katE</name>
        <name evidence="17" type="ORF">B7C42_00445</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47322">
        <property type="protein sequence ID" value="OXR47322"/>
        <property type="gene ID" value="B7C42_00445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="16">
        <location>
            <begin position="27"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR47322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="689" mass="76460" checksum="FED3C4C584D09161" modified="2017-10-25" version="1">MTDNVAGRPGNGGETHQEASGDDVRLTTQQGVVVGDDQNTLRAGERGPALLEDFHFREKIFHFDHERIPERVVHARGFGVHGYFENYDSLSDLTRADPFQEAGRRTEAFVRFSTVAGNKGSFDLARDVRGFAVKLYTREGNWDLVGNNIPVFFIQDPIKFPDMVHAAKQEPDRGFPQAQTAHDNFWDFVSLTPESTHMLLWIMSDRAIPRSFRFMEGFGVHTFRLVNAEGRSTFVKFHWKPKQGLQSVVWNEALKINGADPDFHRRDLWDAIQSGDYPEWELGMQLFDDDFADRFAFDILDPTKIIPEEEVPVRPVGKLVLNRVVDNFFAETEQVAFCTQNIVPGIDFTNDPLLQGRNFSYLDTQLKRLGSPNFTHLPVNAPKCPFATFQQDGHMAMVNPKGRVNYEPNSWPDDIKGPREDPERGFTTYPETISGPERRLRAESFADHYSQARQFFVSQTSIEQQHIVDAFVFELSKCDRVEIRARVVGALRNVHEDLATAVADGLGLAELPEPARCAREPITDLPPSPALSIVRNGPDSVAGRKIGVLVTDGVDAKAFAEVRDAVQAEQAILEVVAPKVGGVTTDDGGRIEADQKIDGGPSVLYDAVVILATDAGAAELATLPPARDFVSDAYAHGKFIAHRNAGSLFAAAGLTGELDAGVMDLAAGASVADFLGRCREVRYWARFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEV7</accession>
    <name>A0A231HEV7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781661.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47419">
        <property type="protein sequence ID" value="OXR47419"/>
        <property type="gene ID" value="B7C42_00542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="25509" checksum="11C23CBFEC49E00B" modified="2017-10-25" version="1">MTIPSWTDIRLGAKRRVALWLMQVVGEGNLFTKSQLREAFPDTQQIDRRMRELRDAGWRIDTNREDPSLEMHEHRFVSRGKPVWEPGQSSRADIAVTATERYALMTRDGHKCRSCGIGPGEKYAGTSVTSQLDIARRAVRMPDGATRTQLVVECNRCRIGSRDLTASLADVMARIEHLPVYERKMLAAWVEQDARSFSEVEELWAHYRTLPAEARDEVRVALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF19</accession>
    <name>A0A231HF19_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DesR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">desR_1</name>
        <name evidence="5" type="ORF">B7C42_00428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777813.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47306">
        <property type="protein sequence ID" value="OXR47306"/>
        <property type="gene ID" value="B7C42_00428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="21727" checksum="2EB6653CC0C00560" modified="2017-10-25" version="1">MAGATAVIRLLLADDQALVRGALAALLGLEADLEVVAEVGRGDEVLDAVRRTTPDVVLLDVEMPGMDGISVAAQLHAEFPRIRILMVTTFGRPGYLRRAIDAGAGGFVVKDTPARELADAVRRVHMGLRVVDPALATETLTAGTSPLTAREREVLAAAADGSTAGVIAKRLHLSEGTVRNHLSAAIGKTGTRTRAEAVRAAERLGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF53</accession>
    <name>A0A231HF53_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47448">
        <property type="protein sequence ID" value="OXR47448"/>
        <property type="gene ID" value="B7C42_00571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28655" checksum="0B07510657F7AF0F" modified="2017-10-25" version="1">MFGQVDRLFAMRLGRVASPDGVAFVSIETDGSDEIAREIAEHPFGTPTFTGRTWPLADVRLLAPILASKVVCVGKNYAAHAAEMGGPAPEDPVIFLKPNTAIVGPNLPILLPPNSSQVEYEGELAVVIGRPCKDVPAARAADVILGYTVANDVTARDQQRHDGQWTRAKGYDTFCPLGPWIETELDPGDLEITTELDGEVRQRSRTSLLLHDIPKVIEWVTRVMTLLPGDVILTGTPEGVGPMTDGQTVSVTVQGIGTLTNPVAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG86</accession>
    <name>A0A231HG86_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddn_2</name>
        <name evidence="3" type="ORF">B7C42_00830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779496.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47705">
        <property type="protein sequence ID" value="OXR47705"/>
        <property type="gene ID" value="B7C42_00830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14967" checksum="CF233BB35A578867" modified="2017-10-25" version="1">MDVREINRGVIEQFRAGGPIEGMHRERLVLLTTTGRRTGTPHTTPMMFHPDGDRLLVVASNVGAPQHPDWYLNLVADPAVTVEVDRETYQATAEPLQGADYDRAWAELTTLYPFFAEHATKTERTIPVVALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSQ3</accession>
    <name>A0A231GSQ3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000102">
        <property type="protein sequence ID" value="OXR39653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39653">
        <property type="protein sequence ID" value="OXR39653"/>
        <property type="gene ID" value="B7C42_08279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="43774" checksum="D6D0DE5E1F6BAD9A" modified="2017-10-25" version="1">MTDEPDIYIGQRVRQIRARRGITQQVLADRSGIGRSALAKYEAGLRPVDSRRTLLALAAALGCTLGDLTGYEQDRIDPSAAGFHAAVPDIEIALWTQGNATHTGPPSSLDDLSRLAQRAAQLRIACDYATLGPMLAPMLTDCYRHIRDAHDDDLYRAWDVLSTIAHTTAAALKARGYGALAWTAAQAAENAARQIGGTAALAAIAFARSQVLLSRPGSLPAALEHAEGTADTIAPDIRTIGEIETFGMLHLQASLVTAAMGGDPEPHLDEAAEHSRRLADAPAGHSILRNPTFGSANVQLWRMSAAMERREPGRVLALAPSLSVDDLPAEGRRAQYFVEIGRAHAMKRDYREALYALLRAEHAAPQHVRNMVHVRELVGHMMRTARRDLTTGDLGKLAQRVGVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSS0</accession>
    <name>A0A231GSS0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000205">
        <property type="protein sequence ID" value="OXR39595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39595">
        <property type="protein sequence ID" value="OXR39595"/>
        <property type="gene ID" value="B7C42_08337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="54" mass="6336" checksum="94489139C1212DFE" modified="2017-10-25" version="1">MAFVVDDIETEYQRVQREGVPIVTPLETEPWGERYFQTLDPNGIVIQLVQWVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT23</accession>
    <name>A0A231GT23_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ferredoxin/ferredoxin--NADP reductase</fullName>
            <ecNumber evidence="6">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fprB_5</name>
        <name evidence="6" type="ORF">B7C42_08155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000068">
        <property type="protein sequence ID" value="OXR39770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39770">
        <property type="protein sequence ID" value="OXR39770"/>
        <property type="gene ID" value="B7C42_08155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR39770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="568" mass="61350" checksum="692F7E007C99C2D0" modified="2017-10-25" version="1">MAYVITQNCCNDASCLAACPVGCIHPTPDEPGFATAEMLYIDPDTCIDCGACADWCPVDAIKADSALTANQQPFRQLNADYYHDNPVRPGWRYKTPPAVVTLARGRLRVAIVGAGPAAWYCAKELLAQPDVEVSIFDRLPTPFGLVRHGVAPDHPATKRIVDQFRFDRDQARRLALFLNVEVGTHVTHADLMDHHHAVIYAHGAATDRRLDIAGEDLPGSLPATRLVAWYNGHPDHARLDPDLNGRRAVIIGNGNVALDIARLLTTDPGRLAGTDIADHALNALRHSTIEEVVIVGRRSAADAAFTTPELLALTQLTDVDVVLDTPITAEEANSAVDAAARRKLALLTPLPTAEQDRTPGRKRIVLRFNSTPVEIVGTSTVEGVVLATTETRVDPDGIRRPIVGDHTETLPAGLVIRSIGFKGTPLPDIPFDDATGTVPNQAGRVTESGSQRPLPGVYTAGWIKRGPTGVIGTNRLCAQQTVANLLEDFLADRLVTPRTGGDELARLVRSRQPDTVDSRGWSAIDTAERSAGAATQRPRRKFTDRDALLDAARQRPARRLPLIPARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTE7</accession>
    <name>A0A231GTE7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000053">
        <property type="protein sequence ID" value="OXR39893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821358.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39893">
        <property type="protein sequence ID" value="OXR39893"/>
        <property type="gene ID" value="B7C42_08039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="38521" checksum="5FC3589228237295" modified="2017-10-25" version="1">MAKYAVVRGKRLRATLVDACGMPLAGPRSRLVTKGFVTVKASPVWKDANDIEQENADGETCVSDRTPPSLKWWALSIELCGVDTALFNMLLDWDVVTSYDGKDIGFSDKKNVPFETGVAIELWSGVGSEDACEVPTSDDILVGAGGNLVLPYGYSVWPVFKEAQLGDLEYGAKASTFTLNGITAYAPRWGRGPYNVMPIDVDNTGGRLLQPMQAEQQHRQFRTTIAPPEITDGACPLILPSPYYGETAAEIAPEQPACGTTATNEKQSVTLTGTPTGGTFTLTYKSQTTAGIAYNAANTAVKSALEALANVGTGNVNVTGTGPYAVEFVGDLAGMDLPLMTASGAGLTGGTTPGVTVAETVKGGVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTH8</accession>
    <name>A0A231GTH8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000056">
        <property type="protein sequence ID" value="OXR39855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39855">
        <property type="protein sequence ID" value="OXR39855"/>
        <property type="gene ID" value="B7C42_08067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="293" mass="31993" checksum="CC4ED276D36DF5DE" modified="2017-10-25" version="1">MTTHPPTDPIADLHARLDAAHALPGGPARERAITEAALAAVVTEIRRRAPSVRYVEFDWAAYGGLDAHAFLDTRGNEIEVPGLAGDLAHWATDLRSPDMAAMIAISPRGPFLLDLEAAPTVTAAGGEPCEGSANPRKRAGRVRDAYCPILVGDQLAYADRPGLLAEVTRLRFESGFLDECEVLRADGVRESVLPWMLVPTDGTIEPWQTRMRMLYAFRRAHANDLLRDNSLALAERADALSRTLAAMAADLRNRVIPHASAMTTQAARDIDEGVEGLASLYDELNYLHEHWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUE4</accession>
    <name>A0A231GUE4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40236">
        <property type="protein sequence ID" value="OXR40236"/>
        <property type="gene ID" value="B7C42_07661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="15373" checksum="BBF9CB9A73DFD7DE" modified="2017-10-25" version="1">MWQYIVPILVGVIASLLAPIVQNIMQALVQNSASRSQRRRDLVDEWRRGLAEAGDSLDDLPAIRSSQWYERLRPYLSDEVRKTFEHGYPPGSTTMVVENFPRPPGQDKQVDLRRRRNTLAARVDELAEKWKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUN3</accession>
    <name>A0A231GUN3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40292">
        <property type="protein sequence ID" value="OXR40292"/>
        <property type="gene ID" value="B7C42_07630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="2">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="27326" checksum="445A65CDC37FEC9A" modified="2017-10-25" version="1">MVDSDRLLTRIGALMRQAEGTDNPHEAEAFLARAQQLATQHSIDLAVARAVAADRGRARPMPGMRRIEIGAKHTKGLATYVQLFVAIAHANDVRVDAAHNSTWVIAFGLGADIDTTQLLYTHLLAQMVRGSRTYLHSAAHQRHPVAGVTARLAYQRAFAARVGQRLRAARDQARADALDTSAPAGPGTALALRDKDIELRDYYTAHSTAKGTWPGHHRAGGHAPAAAEAGDRDGQRARLHGLGEIDGQRKGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVE0</accession>
    <name>A0A231GVE0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40515">
        <property type="protein sequence ID" value="OXR40515"/>
        <property type="gene ID" value="B7C42_07454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="16968" checksum="A7C8B1EA4BC4AACB" modified="2017-10-25" version="1">MDAETPPRAMGYVCADLVKTMHTLEFPMRAVARRLGYNFIGITKSSSLVVMAALLDHVQAHCVELLVVPDLGHLRGRVPPQLAEITDIHDLATGRTHERRGGYAPVDVKLTNPLAGTDTAAAASYSPNGESEPYGTGMVGGHECDAQPQHWPLEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVT3</accession>
    <name>A0A231GVT3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40591">
        <property type="protein sequence ID" value="OXR40591"/>
        <property type="gene ID" value="B7C42_07276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="32" mass="3613" checksum="0BA9DC9E44D156AC" modified="2017-10-25" version="1">MWSGLPATAMTESRWITGVPQNSECLESRFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVT8</accession>
    <name>A0A231GVT8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transport accessory protein MmpS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mmpS2</name>
        <name evidence="4" type="ORF">B7C42_07167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40743">
        <property type="protein sequence ID" value="OXR40743"/>
        <property type="gene ID" value="B7C42_07167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="16923" checksum="EC1FDDC81DF0982A" modified="2017-10-25" version="1">MTNPPNAQQNPYPPGPPPGYYQPPKKRKKWPWVLGGILVLFVVLLGSCMALVGGVAHEVDKESKREVTVTYQVEGTSASSSITYSGRDFNIAQETDATLPWSKQVTIDGLGKTVSLSATTDEQGGDITCRVLVGDKVISEQKSSGPFASAHCTGDAGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWP8</accession>
    <name>A0A231GWP8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41060">
        <property type="protein sequence ID" value="OXR41060"/>
        <property type="gene ID" value="B7C42_06830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="18488" checksum="E3CF58E28AD664A0" modified="2017-10-25" version="1">MDSEQVIDQIAQQLIRLGRIRERTNAQVAATSHGDVDLSAYRIIFRLLWDGPMRSGALAEAMYSDASTISRQVAALVKRGLLRREADPGDGRASVLIVTDAGKEMAAQLRARRNEMIGRILTDWNDPDREQFAVLLHRFVDDYEAARPAILTLPSPTEGRATEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXH2</accession>
    <name>A0A231GXH2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonyl-CoA reductase</fullName>
            <ecNumber evidence="2">1.3.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ccrA2</name>
        <name evidence="2" type="ORF">B7C42_06697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41299">
        <property type="protein sequence ID" value="OXR41299"/>
        <property type="gene ID" value="B7C42_06697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="325" mass="33975" checksum="E14FE6CA52E79D30" modified="2017-10-25" version="1">MKAIVMSDFGGPEQLVFREVDEPICRNGWVTVDLRASALNWHDVLVRRGQYRSPLPHTPGADGAGVRTDTGEEVVILPSLFWGDRHDAPAADFEILGDHVAGTYAERVCVPEQCLAPKPAGYSWEEAAALPLVGVTSYRALVTRAGLSAGESLLIIGAGGGVATMALSLATALGAQAFVTASSEEKLARARNSGAAGGVLHSREDWPGQAKALSPGGDGFDVILDPVGLWDRSVEALRPGGRVVVLGANVAEHVTMDVRRFFFGQYSLLGTTMGGPGDFRGLLNLVATGAVAAPTIAATYSLADAAQAHRRLEAGDTIGKIVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXJ6</accession>
    <name>A0A231GXJ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA:coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cat1_2</name>
        <name evidence="3" type="ORF">B7C42_06706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41308">
        <property type="protein sequence ID" value="OXR41308"/>
        <property type="gene ID" value="B7C42_06706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="257"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="409" mass="43344" checksum="FBC1124C98AE64C0" modified="2017-10-25" version="1">MVDFSGLLRRDMGVWWSQAAAEPRPLVDQLLAQAPELGPLRLFTGLSWNDQLAQAISPTDTMVSYGGLGALRELGATDQLEVVPCHYSALPRMFAEHRLPCDAGLVQVSPPDRDGMCSLGIGVDYMADAIGHTPLLFAEINKQMPAVPGSPRIPLSRFAATCETDRPLQQEARRPASDTDRVIAAHIAGLVDDGDTLQVGIGSLGAAVFDALAGHRDLGVHTGMITDGVLTLIDKGVVTGGRKPIDTGLSVAGTALGSADMYARIAELPVRFRPTSYTHAPQVLSQLDALVAVNFAIEVDLTGQVGAEMSRGTYLGAVGGQVDFARAAALTGKRSIIALRSTMRGRSSIKFGLDEGVVTTARADVDCVVTEHGVAHLRGQPLAERRRRLIDVAAPEFRDELASAARLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXK6</accession>
    <name>A0A231GXK6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780463.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41354">
        <property type="protein sequence ID" value="OXR41354"/>
        <property type="gene ID" value="B7C42_06497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17260" checksum="8BF79B4EF6A375F6" modified="2017-10-25" version="1">MTNPLGSPNRNRPGLPTPPSGWPVASYPTYAEAQRAVDYLADNQFPVENMTIVGVDLMQVERVLGRLTWGKVIGGGMVSGAWLGLFLGLLLSLFTTGGVIGPLVVGLVGGVIFGLISAVIPYAATRGTRDFASTMQLVAGRYDVLCDPKVAEQARDMLARLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY79</accession>
    <name>A0A231GY79_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783595.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41583">
        <property type="protein sequence ID" value="OXR41583"/>
        <property type="gene ID" value="B7C42_06224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011234124" evidence="2">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="18260" checksum="0AA42320BF329252" modified="2017-10-25" version="1">MFLKKLVATILFTIAATAIATVTANGQAEVTDVSLHGVDGTVAYTTNLAADHSRATVDLASGKFSLAPDAITVTADNGSVVGTIPTTLRMQTGETFTVAPSLNSTGTVLTLTPVSAPTTHPVATPDQLNGLLHNALFIGAAVGAGIGCAIGIAIGIWFFVVGAVVGCAVGAVIGAAIGFFAPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYD5</accession>
    <name>A0A231GYD5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase</fullName>
            <ecNumber evidence="1">4.2.99.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menH_3</name>
        <name evidence="1" type="ORF">B7C42_06223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.20" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41582">
        <property type="protein sequence ID" value="OXR41582"/>
        <property type="gene ID" value="B7C42_06223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070205">
        <property type="term" value="F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="413" mass="44878" checksum="90347DDB0F9DC10B" modified="2017-10-25" version="1">MSDRQQSEIEALARLAGDELGGAVDGVATVHRAISDHVFAAVRLGVGPATLPVQVVHDTIADSVYRIVSGSAVSAGVLAQHAATLSGVSTPSRTVFGSGFLAALQGLIGDTLAQQRPILAAPMTFRSAGEPVAPEQLAERITNPSGRVVIFLHGLAETEHAWRLGGRPTYAERLETDLGCTSLQVRYNSGLHISENARQLNDLLERLVEHWPVEVEQLSLVGHSMGGLIARGACFEAAEQGRSWVRRVRQVVCLGSPHLGAPLEQFVHYLSAALVRIPETRPFGRLLRRRSAGIRDLRQGSLVDQDWDDVDADALRRRAIREVPLLEGADHYFVTATITRSPHHPLGRVIGDGLVLTTSGSGRNRARRIGFDDDNGMHLPGANHFTLLNHEAVYEALSHWLRGEREQTSLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYI8</accession>
    <name>A0A231GYI8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_06318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783114.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41677">
        <property type="protein sequence ID" value="OXR41677"/>
        <property type="gene ID" value="B7C42_06318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PTHR43246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17469" checksum="4EC690BDCDCDB433" modified="2017-10-25" version="1">MTTVLLNTSAGDITLELDETKAPQTVANFVDYVKSGHYDGTIFHRVIPGFMVQGGGLTADMQQKPAPNRVQNEAKNGLRNDKYTVAMARTADPHSASAQFFINTANNDFLNYPGQDGWGYAVFGRVVDGNAVVDSIEGVRTGSKAGHQDVPVEPITIVSAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYM4</accession>
    <name>A0A231GYM4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">katG</name>
        <name evidence="12" type="ORF">B7C42_06339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41698">
        <property type="protein sequence ID" value="OXR41698"/>
        <property type="gene ID" value="B7C42_06339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="141"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-107)" evidence="8">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR41698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="741" mass="81001" checksum="D7B23110FC4D01B7" modified="2017-10-25" version="1">MPEEHPPIAEANTEPPESGCPVVGRMKRPVEGGGNRDWWPEQLNLKVLQHNPAEIHPFGADYDYAAEFATLDLAAVKADIIEVMTTSQDWWPADFGHYGPLFIRMAWHAAGTYRIEDGRGGAGSGMQRFAPLNSWPDNASLDKARRLLWPVKQKYGRKLSWADLIVYTGNVALEHMGFQTFGFGGGRVDEWEPEEVYWGPELEWLGDERYSGQRDLENPLAAVQMGLIYVNPEGPNGNPDPLAAAIDIRETFHRMAMNDVETAALIVGGHTFGKTHGAGPADNVGPEPEAAPLEQLGLGWKSSFGTGVGKDAITSGIEVTWTPTPTQWDNSFLETLYGYEWEQTKSPAGAWQWVPKDGAGAGTVPDAHDPSKTQAPAMLTTDLSLRLDPIYGPITRRWLDHPEELAEEFAKAWYKLIHRDMGPKARYLGPLVPEETLLWQDPIPAVDHDLIGDAEITTLKARILDSGLTVAQLVSTAWAAASSFRGSDKRGGANGGRLRLQPQNGWEVNDPDELAQVIRTLEAIQEAFNTEQTGSVRVSFADVVVLGGVAAIEKAARDAGFGATVPFTPGRSDATQEQTDVESFSALEPKADGFRNYLGKGTRLPAEYLLVDKANLLRLTAPEMTVLVGGLRVLGANHKQSPLGVLTDNPGVLSNDFFVNLLDMSTEWKPSPADDGTYIGTDRATGEQRWTGSRVDLVFGSNSQLRALSEVYAADDAKAKFVDDFIAAWDKVMNADRFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYX0</accession>
    <name>A0A231GYX0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4,5:9,10-diseco-3-hydroxy-5,9, 17-trioxoandrosta-1(10),2-diene-4-oate hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hsaD_6</name>
        <name evidence="2" type="ORF">B7C42_06149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41807">
        <property type="protein sequence ID" value="OXR41807"/>
        <property type="gene ID" value="B7C42_06149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102296">
        <property type="term" value="F:4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="31391" checksum="175AF88C7092E8CC" modified="2017-10-25" version="1">MAEFVYRGRRVVYDRAGHGDPIVFIHNAGAQRRIWDDQVASLRDRYEVFALDLPGYGESEQPQGYRLADYVAMLEAFLDEHRLSRVVLVGNCLGSATSLSFAIGDPARVRGLVLINPLTWNTVRHGDQAPLMWFDRFAPLAPLARRLALPKALVTLIVANQLGPRGRDRKLQKDARLQAYWTDRGRLLALDRLVQDFPAFAALDEFIPGPDFPPICTVWGKRNRILSAAAGARLDRTLCPRERLVLSDCGHLPMVEDPETVTSAITAFLAGLPATEQHLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZV9</accession>
    <name>A0A231GZV9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42135">
        <property type="protein sequence ID" value="OXR42135"/>
        <property type="gene ID" value="B7C42_05734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="19939" checksum="BAF0AA37CAB6F7F5" modified="2017-10-25" version="1">MSLDGYINDRDGSIDWSNPDDELHQFHNDRYRDIEISLHGRRLYELMADYWPHVPEDAPPIQREFGRLWTEKPKVVFSRTLTEVHWNSTLVGENAVEQVRRLKAEGDGVMEVGGATLAASLIPHGLIDEYQVFVLPVVLGGGTPMFPLLDERIPLRLAETRHFDTAVMLRYVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H016</accession>
    <name>A0A231H016_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-2-oxovalerate aldolase</fullName>
            <shortName evidence="7">HOA</shortName>
            <ecNumber evidence="7">4.1.3.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-keto-pentanoic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-oxopentanoate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mhpE</name>
        <name evidence="9" type="ORF">B7C42_05794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:36003"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17153"/>
            <dbReference type="ChEBI" id="CHEBI:73142"/>
            <dbReference type="EC" id="4.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22624"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:73143"/>
            <dbReference type="EC" id="4.1.3.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 4-hydroxy-2-oxovalerate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42195">
        <property type="protein sequence ID" value="OXR42195"/>
        <property type="gene ID" value="B7C42_05794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="36450" checksum="3B8BA4888ADF8769" modified="2017-10-25" version="1">MTTQLFIQDVTLRDGMHAVRHRITPDDVGTIVAALDAAGVDAVEVAHGDGLAGGSLNYGPGSNTDWEWIEAAADNLTHARLTTLLLPGIGTIEHLEQAYRLGVRSVRVATHCTEADVSAQHIGKARDLGMDVSGFLMMSHMAEPEQLAEQAKLMESYGAHCVYVTDSGGRLTLNGVRDRVRAYRRVLDPATEIGIHAHENLSLSVANSVVAVEEGVTRVDASLAGHGAGAGNCPIEPFVAVADLYGWKHNCDLFALQDAADDLVRPLQDRPVRVDRETLTLGYAGVYSSFLRHAEAAAQRYGLDARTILLEVGRRGLVGGQEDLIVDIALDLLGESSATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0E9</accession>
    <name>A0A231H0E9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate cyclase 2</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cyaB_2</name>
        <name evidence="5" type="ORF">B7C42_05501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780594.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42302">
        <property type="protein sequence ID" value="OXR42302"/>
        <property type="gene ID" value="B7C42_05501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="318"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="503" mass="53990" checksum="F6207F70648CB2B6" modified="2017-10-25" version="1">MTSRLVLWALRARWGLSTVVMVCNLGGLAVIVVELWLSGFLGNLGEDWLSAVAQTAIYPVIGALAGIVLAVRDRVYYFSWIDQTRRPTRPEAERLLKLPIAITVRALAIWIPGVAIATALFAQVVPTRALWAIGAMFFLGGLESAGFTFLVVDRLIRPTIPVIARVLGGTSHWSATVLNRLVISWAVAGAMPLLMLITVLGDPVADATDRVRTALYMSLVGLLVGALTTATLARSVAAPLGTLRRALDRIARGELSARVPITSASEIGRLELSVNELAENLSERERMRDVFGRHVGNEVAERALAGGVDLTGDVRVVTALFVDVTGSVEMSTELAPREFVDQLNRLLAVVVSATEDNGGLVNKFEGDAALCIFGAPIALGDNATPALRAARRIRDEVALGGEFDIGIGLARGSVFAGDVGTDTRLEYTVIGDAVNEASRLTTEAKEVPRRILASQAVIDAATESERSRWVLYDKIQLRGRREPTACWTDRKPVGLGADAPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H131</accession>
    <name>A0A231H131_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator TtgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ttgR_4</name>
        <name evidence="5" type="ORF">B7C42_05352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42575">
        <property type="protein sequence ID" value="OXR42575"/>
        <property type="gene ID" value="B7C42_05352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="212" mass="23600" checksum="B1689B0481EDD9F6" modified="2017-10-25" version="1">MARTSLLRELPTTERGLRTRSALIAAARRVFETSGYLDTRLVDITTAAHCSSGTFYTYFSSKEEIFAAVLEIAQEDMLHPGMPHVPEADDPAAVVAASNRAYFEAYQRNAKLMGLLEQVANIDPEFRVLRQRRAEAFIDRNARSIESLQRRGLADPELDPLLASRALSGMVSRLAFGHFVGGDDTDRPVDLDELTYTATRLWVNALRIPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H188</accession>
    <name>A0A231H188_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="3">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dapE_3</name>
        <name evidence="3" type="ORF">B7C42_05393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42615">
        <property type="protein sequence ID" value="OXR42615"/>
        <property type="gene ID" value="B7C42_05393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="207"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="449" mass="48854" checksum="8D00F185C0357E69" modified="2017-10-25" version="1">MTGVQRESRSRAEAEVVELVSTLIRFDTSNTGVLETTKGERDCAQWVADQLQQAGYTTEYVESGAPGRGNVFARLPGADPSRGALMIHGHLDVVPAEAADWSVHPFSGAIRDGYVWGRGAIDMKDMVGMMLAVARQFKIEGTVPPRDLVFAFLADEENGGKWGSQWLADNRPDLFEGVTEAVGEVGGFSLTVPRRDGTERRLYLVETAEKGLGWMRLRAKARAGHGSFLHDDNAVTILAEAVARLGKHTFPLVLSDSVAEFLAAVSEETGIDFDPDSPDIEGQLAKLGTISRIIGATLRDTANPTMLRAGYKANVIPQTAEATVDCRVVPGRQAAFEREVDELIGPDVEREWITKLDSYETTFDGHLVDAMNDAILAHDPDGRTVPYMLSGGTDAKAFARLGIRCFGFAPLQLPPDLDFSALFHGVDERVPVSALEFGARVMEHFLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1J2</accession>
    <name>A0A231H1J2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE</fullName>
            <ecNumber evidence="2">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiE_4</name>
        <name evidence="2" type="ORF">B7C42_05053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42716">
        <property type="protein sequence ID" value="OXR42716"/>
        <property type="gene ID" value="B7C42_05053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="22926" checksum="561A98FFBE7F1273" modified="2017-10-25" version="1">MRGMNSLVTRAMSTVAAQLGNPHGVLGKVVAPMLNRANRFAIDAAVEAAEVGAGQAAADIGFGGGVGLSILLREVGDAGTVHGVEISPDMSARARARFTRDIGTGRLRIVEGGLTELPLASASLDAVITVNTVYFVDDLDRAGAELARVLRPGGRVVVGIGDPAAMARMPFTAHGFRLWPVDDVSDALERAGLAVEHRRIDRQPIPAHLLIGRRVRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1S6</accession>
    <name>A0A231H1S6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-beta-hydroxybutyrate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bdhA_2</name>
        <name evidence="1" type="ORF">B7C42_05134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.30" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42796">
        <property type="protein sequence ID" value="OXR42796"/>
        <property type="gene ID" value="B7C42_05134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003858">
        <property type="term" value="F:3-hydroxybutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="28553" checksum="C728677FF7EECB04" modified="2017-10-25" version="1">MSFPQRYGPWALVVGAALGLGAEFCRQLAERGLNLVMVALEKDELDTLATDLADRYGIRTQTVTGDITAPEVLESVALLVDDVELGLIVYNAGLSVCGMWLDTPLERHLKTIDINVTSMMTVLHRFVPPMIERGRGGVVLLSSMSGLLGTPMYASYAGTKALTLNLAESLWDEWRPHGVDVVAVVPGPTDTPGYRADQPRTIRNSPKVMPVAPVVAAGLAALGRRPSVIPGRANRFNGTLLSRVLPRSKAVALMGKSMREMYAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H226</accession>
    <name>A0A231H226_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative iron export permease protein FetB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fetB_1</name>
        <name evidence="7" type="ORF">B7C42_04786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42900">
        <property type="protein sequence ID" value="OXR42900"/>
        <property type="gene ID" value="B7C42_04786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="PTHR30028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="25077" checksum="0C3A57EDD7B0E7E4" modified="2017-10-25" version="1">MSVASPGVGLAVLCLVLVAASAAVYRFAYLGSMLIVPGAAVRAIVQLSVVALVLAAALRHLWSSFLVLGVMFAAAVFTSARRARAGRSGAWLAAALAGGWAAVLPVMLVSGVVPLSGPAVVPVGGIILGGAMTATSLAARRALDAVHDRRGEIEAAMSLGFDDRHARLEIIRSTAADALLPGVDQTRTVGLVTLPGAFVGVLIASGSASRAAAVQILVLLGLLLAQSCAVAVTIELVARGRIRRPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H227</accession>
    <name>A0A231H227_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable potassium transport system protein kup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">kup</name>
        <name evidence="13" type="ORF">B7C42_04784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42898">
        <property type="protein sequence ID" value="OXR42898"/>
        <property type="gene ID" value="B7C42_04784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR42898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="654" mass="70753" checksum="2D27D50379A43728" modified="2017-10-25" version="1">MARAKGTIGGGPAFEVEPDRPPSHTDAVRWGVVVGALGVVFGDIGTSPIYTLQTVFDPGDPHPVPVTTDNVFGVVSLVFWSVMIIVTVTYVLLAMRADNDGEGGIMALITLLRRWSSPRGRKTAIGLAALGIFGASLFFGDSMITPAISVLSSVEGIKVVEPALKDFVIPATVVIIVALFVVQRRGTATVGRMFGPIMIAWFLTIGTCGIGGILRNPRILEALSPTYALGFLIGHFGTAFFALAAIVLAVTGAEALYADMGHFGRRSITRAWLILVCPACTLSYLGQGALILDDARNISSPFFLLAPGWARLLLVLLATAATVIASQAVITGAYSVAAQAAQLGYLPRLRIAHTSESTIGQIYVPWINWLLMVSVLTLVFAFRSSTALAFAFGMAVTGTITITTLLFFYVAQTRWHIPRWILVAGALPLLTVDLLFVAANLTKFAHGAWLPLLIGLTAFTVMTTWQRGRRIVTAERIRREGSLRTFVDELAAGTPATTHVPGTAIFLNRGKETAPLALRANVEHNHVRHHHIVILSIHTEPVPRIPDNERIATDPLGPPDDGITHVTARYGYMETPDVPRALTLVDERDTEGPLDLDHASYFLSTIELRRGTTPTMADWRKRLFIATSYITADAADYFSLPRDRTIIMGSQIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2E9</accession>
    <name>A0A231H2E9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA pyrophosphohydrolase</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rppH_2</name>
        <name evidence="5" type="ORF">B7C42_04909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43023">
        <property type="protein sequence ID" value="OXR43023"/>
        <property type="gene ID" value="B7C42_04909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="166" mass="17986" checksum="9373A2641DD5E83E" modified="2017-10-25" version="1">MRRSGRVILADAEDRILLIAYRGTLDPLYWITPGGGIDAAESPAEAAARELGEETGLRVTAADLGPQVAVAAGYLEIPGWLSGLFREDYFFYRLPTAGADLDTSGLLTYESTAIDEFRWWSVDELASTDQEVYPLGLAGLLGDLLAGRIPPEPVTLPWRDRSGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2K6</accession>
    <name>A0A231H2K6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43083">
        <property type="protein sequence ID" value="OXR43083"/>
        <property type="gene ID" value="B7C42_04969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="19558" checksum="51552AC8B652CB9D" modified="2017-10-25" version="1">MSEEQRSGERLPAEQRSGCPINAAIEVVGDRWTMLVLRDIMFGDRRHFRQLQAQSEEGIASNILADRLKNLVDAGLLTRDEVRRGQRATYSLTEPAIQLVPVLVALGSWGLRHRPTTHELRVRAELLEAGGPQLWAEFMDELRERHLGIARPDTGRPSATQRLAEAYAQAVAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2P2</accession>
    <name>A0A231H2P2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43133">
        <property type="protein sequence ID" value="OXR43133"/>
        <property type="gene ID" value="B7C42_04555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="23993" checksum="029D03A83C111057" modified="2017-10-25" version="1">MTHRIAVSARTAPEPSEEDGGAAEATAAEESSAALASEDTGIGDLDAAADTETAGDAEAAGARTASRSVLRMLLRPGRSAVGAALIVVVLAGLSAAAITLGLAHRASDRVGDQDLAVLSAARQGVVNLISPSAKDPTASANRIAADATGQWLAEFRAVKDKFVGAIDESKTDSTGEILGAGIEHHNPDGSTTVLVTAVSKVSNSTGAKDDPRTWRLRVDVVDEATGYKLSKVEVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Q7</accession>
    <name>A0A231H2Q7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43140">
        <property type="protein sequence ID" value="OXR43140"/>
        <property type="gene ID" value="B7C42_04562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011721">
        <property type="entry name" value="CHP02096"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02096">
        <property type="entry name" value="TIGR02096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16530" checksum="9C8ADE27843AF751" modified="2017-10-25" version="1">MSHTFAIKWLKAFRDSPEAVVALYADDFLFEDPILGQKITDKQELLRVFAPYANKDTENGIGINNFRIDEVVGDEKSAIYRWTWAAPTATAFVGVPTNGKVPGSRGITFHVYNDEGLIVKEASLWDVATSVAELGQPIQPRSVTKSLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H374</accession>
    <name>A0A231H374_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nreB</name>
        <name evidence="7" type="ORF">B7C42_04699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43277">
        <property type="protein sequence ID" value="OXR43277"/>
        <property type="gene ID" value="B7C42_04699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="5">
        <location>
            <begin position="162"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="423"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="514" mass="53885" checksum="0F6CAAE9E65ACF41" modified="2017-10-25" version="1">MIPKPSHGRGWRFRRLSLSMRPAPPSLSLGLTVAALVIAAETVVVLGLERIAPGNSFGVLYLLGVLMISTVWGLGPAVITSVVSAIGFDYFRHWPTESGPVAPQNAITVAVFLIVAVSANTLAALARSHAAEADRRRREADRVARQQAALRRVATLVARGATSSEVFSAVARESARCLGVFNATLLRFQPDGSAVLVAARDEPELPRMPVGMRFTLEGDNVAAMVLHSGTTARMDSHDRAAGSAAALIRFYGLHAGVGAPIVVDGHVWGAIVAGTTGREPLPPDTEQRLAEFADLVATAIANSEAHAELTASRARIVVAADQARRRFERDLHDGAQQRLVSLGLALQTARTAVPSELDTLKTELSQIVRGLVDVSEDLRAISRGIHPAILSNGGLGPALKALARRSAVPVDLAVDIDRSMPESTEVAAYYVAAEALTNAVKHAQASEVTLCATMNDGGLCLRIHDDGVGGADPGKGSGLTGLTDRIEALGGHLHITSHIGHGTTLTAAIPVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H388</accession>
    <name>A0A231H388_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA protection during starvation protein 2</fullName>
            <ecNumber evidence="4">1.16.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dps2_1</name>
        <name evidence="4" type="ORF">B7C42_04694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43272">
        <property type="protein sequence ID" value="OXR43272"/>
        <property type="gene ID" value="B7C42_04694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="17350" checksum="69894EA3CD6C5CBF" modified="2017-10-25" version="1">MTQTETRLGFRASAQLAGHLQRVLVDLTALHLNGKQAHWNVVGHNFRDLHLQLDEIVDAARDASDTIAERMRALDAVPDGRPRTVSAATGLPVLPPGEQDTSSVVDLVTTQIRTTVATMREVHDEVDAEDSSTADLLHAMIDQLEKLAWLLSSENRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Z0</accession>
    <name>A0A231H3Z0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43551">
        <property type="protein sequence ID" value="OXR43551"/>
        <property type="gene ID" value="B7C42_04419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="23244" checksum="2FCAC09D96C4037E" modified="2017-10-25" version="1">MSTPLQRSLFDGFGDIELGPLDGVCRTQLTEGAWVDLLPGWLRGADELFERLATRVPWRADRRPMYDRVVDVPRLLRYYGENETWPDPILEDARAALSGHYGPELGEPFRTAGLCYYRDGEDSVAWHGDTIGRGSTHDTMVAILSIGAPRALLLRPRGGGASIRYHVGHGDLLVMGGSCQRTWEHAVPKTRRPVGPRISIQFRPRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Z3</accession>
    <name>A0A231H3Z3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ORF">B7C42_04432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43564">
        <property type="protein sequence ID" value="OXR43564"/>
        <property type="gene ID" value="B7C42_04432"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="183"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="188"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="42100" checksum="ED81D82B72CE9F48" modified="2017-10-25" version="1">MRIVVGVGGGIAAYKACSLVRKFTETGHDVRVIPTESALQFVGKATFEALSGNPVHTGVFADVPEVPHVRIGQEADLVVIAPATADLMARAASGRADDLLTATLLTARCPVLFAPAMHTEMWEHPATIANVATLRAHGSTVMEPASGRLTGADTGPGRLPEPEEIFALASLLLERSDALPRDLEGRRVVVSAGGTREPLDPVRFLGNRSSGKQGYAMARVAAQRGAQVTLIAGNTIGLEPPAAVEVVHVTTAEQMGTAVDKHSAGADAVIMAAAVADFRPVNVAAAKIKKGAHEPNSIELTKNRDILAGLVQARRDGQLGGLAIVGFAAETGDEHGDVLTHARAKLARKGCDLLVVNAVGDGKAFEVDNNDGWLLGADGTEQSLDHGSKALLASRVLDALGPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H478</accession>
    <name>A0A231H478_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43630">
        <property type="protein sequence ID" value="OXR43630"/>
        <property type="gene ID" value="B7C42_04498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="15874" checksum="E7B241A0214E87B5" modified="2017-10-25" version="1">MFADLNGAHGFQFYTPCAANTDRAVGRALPDGKLHAMSETATAAPVAPSSTVVESVKKFVAAHGGSGTAVLQPIGRIGVRITLVGADGVLGDRVVADLATAKAVVEAVDGLAETEHWDRDLSSIATPAKGHWARMAGWVARQTRFPKARNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4G2</accession>
    <name>A0A231H4G2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">murB</name>
        <name evidence="19" type="ORF">B7C42_03989</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43754">
        <property type="protein sequence ID" value="OXR43754"/>
        <property type="gene ID" value="B7C42_03989"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXR43754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="363" mass="37444" checksum="61C3109F9E1FD4A7" modified="2017-10-25" version="1">MVAFDNVRELLSATGAQVRESVPLAQLTTLRVGGPATVAECRTTEALVETVRTLDAAGVPVLLIAGGSNLLIADGGFDGVVVRIATDAVELGSGSVTAEAGADWDGVVAATVAAGFGGLECLSGIPGSAGATPVQNVGAYGVEVAQVLRRIRLLDRASGEIRWAAPEELGFGYRTSVLKHSDRAVVLAVEFAVNPDGASAPLRYGELARAFDATDGESRPAAAVREAVLALRAGKGMVLDAADHDTWSAGSFFTNPVVAHDRAPAVLDAIRAHVGDITIPTYAAEGGVKFSAGWLIERAGFGKGFPGPEAPVRLSTKHTLALTNRGSARAADLVDLARIVRAGVEQRFGIRLEPEPVTVGLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4I7</accession>
    <name>A0A231H4I7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme chloroperoxidase</fullName>
            <ecNumber evidence="2">1.11.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cpo_4</name>
        <name evidence="2" type="ORF">B7C42_03992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.10" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43757">
        <property type="protein sequence ID" value="OXR43757"/>
        <property type="gene ID" value="B7C42_03992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016691">
        <property type="term" value="F:chloride peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="285" mass="30301" checksum="96BD2974240B077E" modified="2017-10-25" version="1">MPQSRPVSLTSMAIREVVSADGTNIVYQLSGPEQGRPLVLLHGWAGTLRCWGRAAEILAETFRVIAVDLRGHGYSGAPEAGYDDPKNWAADVAAVLAGEDITAGAVLLGWSYGGIVLSDYLTAYGTGALAGVVYCGSQAGIGRGVEGSQPGPAMQKAIPDVFEESAGRAMRGFAAFGNANTGPGRDKGEDAQRLFGGSLATPPRVRKALFYRTVDNTEALRNLDVPVFVMHGTADPVVPVENGRYIAEQAPESRTSFWDDAQHGLFVEDPQRFADELTEFVASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Q6</accession>
    <name>A0A231H4Q6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Nitrate reductase</fullName>
            <ecNumber evidence="22">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">narB_2</name>
        <name evidence="22" type="ORF">B7C42_04079</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="22"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43844">
        <property type="protein sequence ID" value="OXR43844"/>
        <property type="gene ID" value="B7C42_04079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
        <property type="entry name" value="MopB_CT_Nitrate-R-NapA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041957">
        <property type="entry name" value="CT_Nitrate-R-NapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="21">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="19">
        <location>
            <begin position="820"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="1033"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="965"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OXR43844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1399" mass="151122" checksum="B5291ABE9AE8780D" modified="2017-10-25" version="1">MSSAENSTSTVRTACSYCGVGCGITVRTERDAAGAPVIAKVSGDKLHPVNAGRLCTKGATHLELMRAPGRMTTALHRPRRGQEPVELAVEEAVRQAARRLRAIVDEYGPDAVALYVSGQMTLEAQYLANKLAKGYLRTVNIESNSRLCMASAGTGYKQSLGADGPPGSYDDLDRADLFFVIGSNMADCHPILFLRMAERLKAGAKLIVVDPRRTDTAARADLFLQIRPGTDLALLNGLLHLLVGNGDIDAEFIAAHTEGWEAMPEFLAAYPPARVAEITGLAEDDIRTAAAWIGAAGEWMTLWTMGLNQSTHGTWNTNAVCNLHLATGAVCRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSALVDADRRFVETAWQLPAGTIRAESGRGTIDMFRELADGRIKACWIICSNPVASVANRKTVIAGLEAAELVITQDAYLDTATNAYADLLLPAALWAEADGVMVNSERNVTLLRHSVEPLGAALPDWEWIARIATAMGFEGFDYSSSAEIFDEIRGFANPATGYDLSGMSHAALREGPMQWPCADAAQRRNPIRYRTGDAGALVFPTASGRAVFWPRPHMAAAEMPDDDYPFVLNTGRVQHQWHTMTKTGRVAKLNKLNPAPFLDVHPDDARALGVRPGDQIEIASRRGRAVLPVQITDRVRPGACFAPFHWNDEQGEYLTINAVTNDAVDPDSLQPEFKACAVTLRRVGPARDTRDDTGDAPAPHPLAAMLGLDSASAPTLSEAERIYLGGYLAALQSLPVQGQPVLPESAPLSDRSRWWIDGLLAGMYSRAPDYPPGGTAAAPSAAPAGPQRRPVTVLWASQTGTAEELAAALAAALAAHGHAPRLVEMNACELRELTGDVLLVTSTFGDGGPPDNAADFWDRLQDSGTRFNGLRYGIFALGDSSYDDFCGYGRKVDRLLSERGGVRLLDRVDSEPDHEDSSQEWITAVLAALGDGRGNAATDDGAGAPSGGGAAATRSGGEGVGATTDDGRAGAPAGLGVRVLDRVEARTAAPARTTRSVPAPFTRNAPVPAPLVRNELLSRPGSGKEVRQFGFDLNGLEAAYEVGDSLGVWPANGTAAVRNWLAATGLDGARPVEIDGRDVPLESALRTHFDITKINGDLLSFVAAHNPSQQLAKLLRRDNRNELDRYLWDRHAVDVLRDFPVRADLVEWLAVLKKLQPRQYSISSSPLVSPREVQLTVGVVRYGAADDPRGGVCSTFLADRDETGGVPVFLQRAPHFRPPLDPNAPMIMVGPGTGIAPFRGFLHERRALGCRGRNWLFFGDQHAQDHFYYRAELEDMFRSGFLTRLDLAFSRDQRERIYVQHRMIEHGAELWTWLRDGAHLYVCGDAARMARDVDDALLTIARIHGNLDEEAALAFKKQLTAEKRYVRDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4R1</accession>
    <name>A0A231H4R1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43851">
        <property type="protein sequence ID" value="OXR43851"/>
        <property type="gene ID" value="B7C42_04086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019639">
        <property type="entry name" value="DUF2505"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10698">
        <property type="entry name" value="DUF2505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="176" mass="19144" checksum="AF28B66B6DDED2E3" modified="2017-10-25" version="1">MVPIACALMSRNFRFTVSYTVPVEELHRALTSDEFWHARFEGAETATIELTHPNGPGTIHLRMTETARQDKIPAIVRKVLKAELVLERTDDWGPLEGNSAAGTFSATSSGISSEMTGKYLLRAAGTGSELEVTGSVKVKVPLVGGAIEPLAEQLQHRVVNSERKFVEKYFAAESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H522</accession>
    <name>A0A231H522_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777235.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44043">
        <property type="protein sequence ID" value="OXR44043"/>
        <property type="gene ID" value="B7C42_03599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="240" mass="25820" checksum="67D7DB74FCF38617" modified="2017-10-25" version="1">MASRKTAGLRTVDVARQAGCSVQQVRNLERDGVLPAAERGSSGYRTYREVHVLSARAYRLASAALGPAEARVVLREAHSGQRLPVLMDAAHARLDAQRRELRLAQRAAEAIAEEPIGDAKPADSMTVSELAGALGVRPSTLRHWDAEGLVVPGRARGARLYAPEDVRDARIAHQLRLAGYRIPALRELLSASRTFRGGDVSAALAAREAEIDTRSWALFEAAALLFRIVSASGDDSVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5H9</accession>
    <name>A0A231H5H9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_03697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777427.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44139">
        <property type="protein sequence ID" value="OXR44139"/>
        <property type="gene ID" value="B7C42_03697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="30029" checksum="C4F056F3D0BC5165" modified="2017-10-25" version="1">MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVEQELSRLIEENADLRQRVAELDAELADAKKSRPAPQAVKPAPPQPEPPKPAPVAPPVPVPAPAPVAPKDNSAADANLQAAKVLSLAQEMADRLTTDAKAEAEQLLSNARANSERMVSEAQTRSDAMVGEARQKADSLLSDAQTRSDSQLRQAKEKADALQADAERKHTEIMATITQQRSVLESRIEQLKTFEREYRVRLKSYLESQLEELENRGSAVPVDGGEAFEAVSNSHGPASFAKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5J2</accession>
    <name>A0A231H5J2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase DbpA</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dbpA</name>
        <name evidence="4" type="ORF">B7C42_03542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR43986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783850.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43986">
        <property type="protein sequence ID" value="OXR43986"/>
        <property type="gene ID" value="B7C42_03542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="264"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="723" mass="78765" checksum="D70A9901B08D49C6" modified="2017-10-25" version="1">MIEQAAPNPIERLDTVLVHHIVNTLGWPDLRPLQRASIDPLLRGDDAILLAPTAGGKTESACFPLLTAMAAGNWPGVSVLYLCPLKALLNNLVTRIDTYAQWIGRSAALWHGDTSESARNRIRREPPDILLTTPESLEAMLIGIKTDHQALLGSVRAVVVDEVHAFAGDDRGWHLLAVLERLQRVTGQPIQRIGLSATVGNPHRLLAWLQGSGSGRRRGTVVAPDLPELATQDTPAGSRFPTDSPPLPRPAGEVELDYVGSLDNAAKVIAALHRGEKRLVFCDSRRQVEQLGAALRERDVTVFLSHASLSASERARSEQAFAEARDCVIVSTSTLELGIDVGDLDRVIQIDSPSTVASFLQRIGRTGRRAGTTRNCLFLTTTTDALLQAAGLLLLWSRGWVEPVTAPPQPRHLVAQQLLAVTLQHGTIGKRLWSQEWNGLAPFDRSAEPIFTYLLEAGYLDSDQELAFIGPQAEHRFGKRNFLELTASFTAPPQFTILAGRQEIGMTDVSVLTDDRPGPRLLLLAGSSWRVTYIDWQRRRAFVEPAEGGGIAKWSSLGIRGLSAELCRAMREVLLGSAPDVSLTRRAQTALTGHRQEKAGTVARDATLITREESGTRWWTWAGYRANATLAAALAPVADPAQRPDDFAIRLDSGLTPAVWTAMRKTVDVDRLPLPGVDSRAVAGLKFSALLPDQLASATIGSRLTDPQTAQVVLREPVRWSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5L2</accession>
    <name>A0A231H5L2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042290.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44184">
        <property type="protein sequence ID" value="OXR44184"/>
        <property type="gene ID" value="B7C42_03744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021213">
        <property type="entry name" value="DUF2567"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10821">
        <property type="entry name" value="DUF2567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="21791" checksum="A3F2B3A19CC02F08" modified="2017-10-25" version="1">MTSRGAAAASPAPRELRAALWIVAAVLVVSIIGGGVWAMLAPTQKVFVVEPGSGMALTGESAHRFDAVAIFACVGLVTGLLSAAAVWRRRAIRGPIMLVSLLIGSLAGAWVMSWFGEQVARWIHPRSHNPPVHTVVELAPTVEGWTALLLQPLIAGLVVLLLSALSTSEDLGSGRGETAEPAPRTLSDVTYGPYHRPGSYQNADSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5N8</accession>
    <name>A0A231H5N8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gtaB_1</name>
        <name evidence="5" type="ORF">B7C42_03704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44145">
        <property type="protein sequence ID" value="OXR44145"/>
        <property type="gene ID" value="B7C42_03704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="31589" checksum="34248C41119D5F5E" modified="2017-10-25" version="1">MTIRKAVIPAAGIGSRLLPLTKAIPKEMLPVGDKPVIEHTVRELVASGITDITIVVSGGKSLIQDHFRPNPALVAQLRADGKSAYADAVEEVGELGRLGHITYLDQHGPYGNGTPVLNAARALGDEPMLVLWPDDVFVAEVPRAQQLIDAYNKTGSPVLALMPMDPADSQRYGVPVVEDSYEPGLMRISGLREKPKPEDAPSAYAAIGGYVVTPGIVDELRKQVDQWYTHHTGEVYLTDAINVFAASNPVYGQVIRGRWYDTGNPADYLAAQFASALSHPQYGPLLRDLCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5W2</accession>
    <name>A0A231H5W2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monoterpene epsilon-lactone hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mlhB_3</name>
        <name evidence="6" type="ORF">B7C42_03757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.83" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44197">
        <property type="protein sequence ID" value="OXR44197"/>
        <property type="gene ID" value="B7C42_03757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="5">
        <location>
            <begin position="70"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="31808" checksum="2A43FC0F34CD1A1F" modified="2017-10-25" version="1">MSEEQRAQVDAMLRRPHPAQPRSVAEIRADFRTLMAQMAVPSGIRTRTITLGTRPAVLVEPPEPAGAGTILYFHGGGFVFGSPGTALTLTGNLVCKTGFRALSVDYRLAPEHPFPAAIEDTLGAYRALLDSGAQPSAIAFAGDSAGGGLTITTALAARDAGLPLPAAIVAFSPGLDMTRTGASMETKAGIDPLFTRASLDHTGAMYLAGQDPEQPLLSPAVSADLTGFPPILLQVGTNEMLLDDSTRLAARAREAGVDVILDVTADVPHVFQSFTGLLDEADEALDRAAHFLGQRIRIRDRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5X9</accession>
    <name>A0A231H5X9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_062998936.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44245">
        <property type="protein sequence ID" value="OXR44245"/>
        <property type="gene ID" value="B7C42_03806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="59" mass="6640" checksum="597F9FA3D29A849C" modified="2017-10-25" version="1">MAKREPKKVLVRLDPAVHEAIAKWAADDLRSINAQIEYALRMALDQVGRSPRRAGETPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D2</accession>
    <name>A0A231H6D2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_03373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44583">
        <property type="protein sequence ID" value="OXR44583"/>
        <property type="gene ID" value="B7C42_03373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="461" mass="50074" checksum="0A5309D77F753A19" modified="2017-10-25" version="1">MGSPCQSNGCQTHPDQAAPVHRYAEPVNDRSRVADPDELPATTSSARSTGGLTTRQRRLLMIAIALFVVSAIVSWAAHIWTGYIDLQVYRNGAHTWLDGGDLYGPMPKVHGIGLPFTYPPLAALFFAPLALMPLAVAEWLVLLTSMASLAVTLWLVLVRVRPRMDRSTRVILLIGALAVLGLSEPVRQTYNFGQINLILMAAVALDALVRKPFWPRGTLIGITVSVKLIPAGYLLYFLLRRDWRACLTLIASAIGAIALAFLLFPHDSTEYWFHTLIDTGRIGPPQYAGNQSLKGFAFRLGVSDAAATGIWIGLSLIAIGLAALWMKRLLDAGHQVSALLVNSAAVLLVSPVSWSHHWVWVAPALLVAGDLIARMPAADAPGTPGRAARRRMWIAITAAITVLFMVGPQWVLPHNADRELRWAWWQQIIGSSYVLVTFAALVIAAIAYRPSGVRNAASAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6E1</accession>
    <name>A0A231H6E1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">coaX</name>
        <name evidence="7" type="ORF">B7C42_03207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775709.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44418">
        <property type="protein sequence ID" value="OXR44418"/>
        <property type="gene ID" value="B7C42_03207"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="28605" checksum="1713DD8D0CFBCF19" modified="2017-10-25" version="1">MLLTIDVRNTSIEIGLFSGSGAHAELVHTWRVHTNPLLTADEFAMQVRGLVGERLDQVVGVSALSTVPPVLRELRTMLGRYWSHVPHVLVEPGVRTGIPLLVDNPKEVGADRIVNCLAAYHRFESPAIVVDFGTAICVDLVSAKGEFLGGTIAPGVEISTEALVARSALRRAELARPRSVVGKNSMECMQSGAVFGFAGLVDGLIDRIRDELDAFAGDDVSVVATGPTAPLIVPESETIDHHEPHLTLDGLRLVYERNQQRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6K5</accession>
    <name>A0A231H6K5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxosteroid 1-dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kstD_3</name>
        <name evidence="5" type="ORF">B7C42_03258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44469">
        <property type="protein sequence ID" value="OXR44469"/>
        <property type="gene ID" value="B7C42_03258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047571">
        <property type="term" value="F:3-oxosteroid 1-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="567" mass="60886" checksum="B87CAF9C6C97535E" modified="2017-10-25" version="1">MTDREYDVVVVGSGAAGMTAALAAAHHGLRAVLIEKAAHYGGSTARSGGGVWIPGNKALKASGRPDDREEARRYLHSIIGDVVPEEKIDTYIDRGAEAFDFVLDHSPLKMTWVPGYSDYHPEAPGGLGSGRSCEPKPFNLKVLGAEAANLEPPYAKAPLNVVVMQTDFVRLNLIRRHPKGMMRAMRVGARTYLAKFTGKQIVGMGQAIIAAMRKGLQDANVPVLLNTPLTKLITEDGRVVGVEATVDGEPTIFKARYGVVLGTGGFEHNAEMREQYQRKPITTEWTTGAAANTGDGIRAGMEVGGDIGFMEDAWWGPTIFKGGKPWFALAERNLPGAIMVNADGKRFGNESAPYVEAVHTMYGGKWGQGDGPGENIPAWLVFDQRYRNRYIFAGLQPGQRFPSRWMENDNIVKADTLEELARRLGVPADNLAATVARFNAFAEKGVDEDFGRGKSHYDRYYGDPTVKPNPCLAALVQGPFYAAKIVPGDLGTKGGLVTDTAARVLRADGSVIDGLYAAGNSSTPVMGHTYAGPGATIGPALTFGYLAVMDIVEKAREEKAPTSAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Q3</accession>
    <name>A0A231H6Q3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775928.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44519">
        <property type="protein sequence ID" value="OXR44519"/>
        <property type="gene ID" value="B7C42_03308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="36498" checksum="0EC13C16BDAB8BD2" modified="2017-10-25" version="1">MTFWLTALLVWMAAGARIGRVLVKPATTARVAIVIAVAAVAAAATLGIPEIAVAVDHALPQGINGAALADRLVVATWLLFAVATSVVAAAAWPVVSRRNLRQIAWMVYGFGALVIAATIGWSMLFGWVMTLLGCAFIAVTGLRNLDWTALGRGIALYTTGTVIAGVLAALSIRRLAIGDHPVRPGDPGWFWPVWQLASLLIAVGAVWIVIELWVRARLLLRQIRALHRTMIKRFPEVVAHEQTVSATQLKASDQVAQIMDALYLQTGGGMEVAAAGVPARSVTDRAERVARWARNPLGDEIVDARWIAPPEGLSPRGWVQAIARAFEHTAADRKSAVAQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6S6</accession>
    <name>A0A231H6S6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44723">
        <property type="protein sequence ID" value="OXR44723"/>
        <property type="gene ID" value="B7C42_03517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="958" mass="100567" checksum="7B96837C96762A58" modified="2017-10-25" version="1">MVSTVGIAAPRNIRADHGIHHGSGTWWHRYGRQNGHVSKQIAAEISAREAEVLALVGQHRSNAEIAAQLFISVRTVETHVSSLLRKAGVPDRRALAERAGALGDRRPAAAPVTVLPTTLTSFVGRAREQAELRALVAAHRQVTALGPGGVGKTRLTLAVAAESADEFAGGVWFVDLVPVTDPEMTGAAVAQALGIGEQPGRDLDDSVAAALGDRRLLLVLDNCEHLLDGVAPFLERLLARCPGVTVLATSRSRLMVPFEQVYAVPPLTLAENADAVALFLDRAEALGWSVPPEQTDRVAEICARLDGLALPIELAAARLPTLGLDGLTASLSDPLRLLVGGRRADERHRSVRATLDWSRALLTESDRRLLQRVAVFAGPFTAAAAAEVTGGPPLTPEEVPDGLARLTEQSLLTVVPAGTGIRYRMLATVRQYAREQLDSLGELPDMLARHLAWSRVTATALAHRSETDSWRTEFDGVADDLRAALNWAAAEPEQRAAASELALTLARITFTRNLIGESQRRYEQAAALTEEPSVAAEALREAAATAGCRLHGSEMYRLYLAAAEVARSSGDDAAAAAARDLATAVSTCFRMSDTFDEPPALPEAIELLATARSLAGDDPAAAAAIALAECGLRAAESEGSQAIASAERAVGLAGRTADPLARSAALDALAAAQWWCGDAAASAVTTRRRVELLAAAPPTAAGALERVGALSEAADSCVGNGDLAGAQLWATQLRDLPLLAERGDLATSRVLVARALAGDAHAVGADSQRFADARELSGRARAPQLAVSAAAVALIHGLRGDLPAQARWQASAAELSGAPAAWRAVFAALQSLHAGHAHRAWAELATAPDDLDQQELWIWRHWYVALRAEAAVLAGRPNAATILDSARHAVMGNPIATAIVSRGIALLADDRPAVLATAADFEAAHCPYQQARSSILALDPDGAALLDALGLTPDRSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6T9</accession>
    <name>A0A231H6T9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative CoA-transferase subunit beta</fullName>
            <ecNumber evidence="1">2.8.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775899.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44512">
        <property type="protein sequence ID" value="OXR44512"/>
        <property type="gene ID" value="B7C42_03301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="27140" checksum="A74BE7801E52EDF1" modified="2017-10-25" version="1">MSETTTVTRAEVCAVACAEIFRGAGEIMASPMSPTPTIGARLARLTFEPDLLISDGEALLLADTPALGAKAPTEGWIPFGKVFDVVASGRRHVVMGANQIDRHGNQNLSAFGPLQQPNRQMFGVRGAPGNTINHATSYFVPKHSKRVFCETVDIVCGIGYDKIDPENPAYRFHHLHRVISNLGVFDFGGPGHTLRALSLHPGVSADEVAENTAFEVAGLDSAEVTRTPTDEELRIIRTVLDPKGIREKEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7C3</accession>
    <name>A0A231H7C3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44626">
        <property type="protein sequence ID" value="OXR44626"/>
        <property type="gene ID" value="B7C42_03420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167059" evidence="1">
        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="13146" checksum="7EEDACB5AF4F4000" modified="2017-10-25" version="1">MTVVRKVVLGGAIAVLLGSGAGAAAAETVPFQINPAPYGNPNGSVDSLPARCVAGTGARAGEITITGANDRGWGCYSAPVRWLNLATGASGEAHLSDGLNGIPPAVTVVTGSGPVVAVVLTGGVYTPGLVSVQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7M6</accession>
    <name>A0A231H7M6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44848">
        <property type="protein sequence ID" value="OXR44848"/>
        <property type="gene ID" value="B7C42_02802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="31370" checksum="46A5C597EDC311EF" modified="2017-10-25" version="1">MSRPRPGRTVTGMQVGQPSTTAMATAQARAYHQLADEPRIFTDPLAVRIVGEQAARDNPFDKGVDPELARRRRLFLATRSRFADDTVAEAVAGGTRQVVVLGAGMDTAAYRNPHPEVRFFEVDHPDTQAWKRNRLSEAGIEVPQSMTFAPVDFHRDDLADALAQAGLDRARSAVYVWLGVVVYLEHDAIAETLRYIAGQGGGADLVFDYSYPPDAGQQARGKRVAAVGEPWVSFFTEEQMRSELESAGFTDIEDHSGIALVRSYADLPADGPALPGPHLVRARTAVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7M8</accession>
    <name>A0A231H7M8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777186.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44792">
        <property type="protein sequence ID" value="OXR44792"/>
        <property type="gene ID" value="B7C42_02746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="11087" checksum="E4DF36472E754356" modified="2017-10-25" version="1">MDATPRQIIVTGYLRVDPADRDRYLATCVEVVNAARQTRGCLDFALSADLVDAGRINILERWSDRAALDAFRGAGISGEQGAMIREAQVTEFTVGDETLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7R0</accession>
    <name>A0A231H7R0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">betI_9</name>
        <name evidence="6" type="ORF">B7C42_03010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45053">
        <property type="protein sequence ID" value="OXR45053"/>
        <property type="gene ID" value="B7C42_03010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="25957" checksum="A332BB8CDC8C0C03" modified="2017-10-25" version="1">MNCDTPDSPPSNSSHSSDPHASDPVFAAAPHPGALPLEAVAVELPPSAITTALPVAEHSERSDAVRNRQLLLDAAEELVREFGADSVTMDAVAKRAGVGKGTVFRRFGNRSGLMLALLDQSEQKLQAAFMFGPPPLGPGAPPLQRLIAYGRARLAGIEVEGEMRRAADESGRYASAPYNISKTHVSLLLRQLEVGGDIALTADTLLAILDAGLVLHQLRVLGYRPEQIADHWENVVRALVAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7X5</accession>
    <name>A0A231H7X5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">aceE</name>
        <name evidence="13" type="ORF">B7C42_02856</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44900">
        <property type="protein sequence ID" value="OXR44900"/>
        <property type="gene ID" value="B7C42_02856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="181"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="12">
        <location>
            <begin position="529"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR44900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="974" mass="107635" checksum="BBB5DEC39895AF0B" modified="2017-10-25" version="1">MTDLMHPISSSSASDPEPTSSNGSADHQSAPARPAGARVRVIREGVASYLPDIDPEETSEWLDSFDEMLEREGPGRARYLMLRLLERAGERHVTIPSLTSTDYVNTIPTENEPWFPGDEEVERRYRAWIRWNAAVMVHRAQRPGIGVGGHISTYASSAALYEVGFNHFFRGKDHPGGGDQIFIQGHASPGVYARAFLEGRLTEDQLDGFRQEYSHGGPGHGLSSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHYLHDRGIKDTSDQHVWAFLGDGEMDEPESRGLLQVAALEGLDNLTFVINCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIKVIWGREWDALLGADRDGALVNLMNSTPDGDYQTYKANDGAYVREHFFGRDPRTKDLVKDLTDQQVWNLKRGGHDYRKIYAAYAAALAHQGKPTVILAKTIKGYGLGKHFEARNATHQMKKMTLDDLKAFRDVQRIPITDAQLEADPYLPPYYHPGMDSHEIGYMLDRRRALGGFLPERRSTAKPLPLPGDAPYASVRKGSGKQNVATTMAFVRLMKELLRDKEIGKRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTSVDAELMLAYKESQVGQILHEGINEAGSTASFTAAGTSYATHGEPMIPLYIFYSMFGFQRTGDGLWAAADQLARGFVLGATAGRTTLTGEGLQHNDGHSLLLASTNPAVVSYDPAFAFEIAHIVRDGLRRMYGGGRPQLGPGGTPASEVPGTHPVMKDDVFGGENVFYYITLYNEPYQQPAEPDDLDVEGLLKGIYRYRRGGDGDVRAQILVAGVTVPDGLRAQELLAQDWGVQADVWSVTSWSELRREALAKEIHTLRHPDAGTDAPYVTRVLSQAQGPFVAASDWMRAVPDQIRKWVPGDYTTLGTDGFGFSDTRQAARRVFNVDAESIALAALEALGRTGGIDPAVVAQAAARYRIDDVDAAPKSMSSEEQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H814</accession>
    <name>A0A231H814_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45153">
        <property type="protein sequence ID" value="OXR45153"/>
        <property type="gene ID" value="B7C42_03110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="32915" checksum="4614EB8278DF2AB2" modified="2017-10-25" version="1">MSGMAVIAVASVLCMNHLGLHFDIGENRRTATMAVRDTNGLALGSKVLLRGVEIGEVERMTPSASGVEVEWKYDDSYRIPVHSNFRVDTLSAMGESYIAVSPAATAGPYLPDHARIPSGDVTVPATIQDLSAHLTRLLDQVKPEQVRDIVAQLDIALPNHGVVLVDLSRAWSLFADMTLDRADDLTAVLTKFQALLADSTWISPDLAGSANIVRKFGVGFGDFLDSAVGTTRVAPLPEGISEGVGPFIDKLQQFLDKAAPDLQVLGVAILPSVRAASAAMRTVDISALLDRAIADSSGGAVTVHVGVPEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H836</accession>
    <name>A0A231H836_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051024835.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45019">
        <property type="protein sequence ID" value="OXR45019"/>
        <property type="gene ID" value="B7C42_02976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15028" checksum="0D8084EF06997990" modified="2017-10-25" version="1">MATPGTTVTDGDNKLSWMLEDLTVPGVRFAVLLSEDGLRIAHVGAISLDDAERFAAAASGLRSLGKALSEFCGPANTVRQNMTEYDEGMIFITAAGEGALIGVSTMPDVDVSMVAHRMNELAVRVGRELGSLPRHRPGSDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H860</accession>
    <name>A0A231H860_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44972">
        <property type="protein sequence ID" value="OXR44972"/>
        <property type="gene ID" value="B7C42_02929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="29247" checksum="4BA9001DB70C9F4F" modified="2017-10-25" version="1">MPRFDPHPDVRPVLIAGASSGIGAATAIMLAEAGFPVALGARRVETCRELADKITADGGTAFAGSLDVTDDASVDAFVTAAEEALGPIEVAVSGAGDIEFGLAYEMDPQTFLKQVDVHLVGAQRLAHRILPGMISRRRGDFVFIGSDCADQVRPRNGAYNAAKTGLEAMARQLRMELEGTGVRASIVRPGATQTGMGMNAAPEQVGPLLDDWVKWGFARHPFFLRASDLAAAIAALVNTPRGAHLVLVEVQPEAPLREPERADKEALRRADKDGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8W6</accession>
    <name>A0A231H8W6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776721.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45298">
        <property type="protein sequence ID" value="OXR45298"/>
        <property type="gene ID" value="B7C42_02423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12783" checksum="0829918B891D86BD" modified="2017-10-25" version="1">MSRPQQQIPSVTVAASTNRAGTISVRATDQGIPVEIKFERSEYRYGAQALAAEILRLTKRSAIVAKARRRELLAESGMPTEILDKLGLPTRQEAVDELDRMDDEDTGPTSWMRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Z4</accession>
    <name>A0A231H8Z4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Adenosine deaminase</fullName>
            <ecNumber evidence="1 3">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">add</name>
        <name evidence="5" type="ORF">B7C42_02426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1 3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45301">
        <property type="protein sequence ID" value="OXR45301"/>
        <property type="gene ID" value="B7C42_02426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046936">
        <property type="term" value="F:2'-deoxyadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="358" mass="39581" checksum="0243EB2B007F6C0D" modified="2017-10-25" version="1">MTLASIRQAPKAVLHDHLDGGLRPATVLELAEDCGYDQLPATDAEALAHWFREAADSGSLERYLETFAHTVAVMQTPEGLRRVARECALDLAADGVVYAEVRFAPEQHLERDLTLDEVVEHTLAGFREGERLAAEAGTPIRVTCLLTAMRHAARSREIAELTVRFRDRGVGGFDIAGAEAGYPPSRHLDAFEYMRANCAQFTIHAGEAFGLPSIHEALAFCGCDRLGHGVRITDDIFDSDTAEPTLGLVANYVRDKRIPLELCPSSNVQTGAVPALDKHPFDLLARLRFRVTVNTDNRLMSDTDMSREMLKLVETFGYGWSDLERFTINAMKSAFIPFPDRLRIIDEVIKPGYAVLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9G2</accession>
    <name>A0A231H9G2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ESX-1 secretion-associated protein EspG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">espG1</name>
        <name evidence="2" type="ORF">B7C42_02595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45470">
        <property type="protein sequence ID" value="OXR45470"/>
        <property type="gene ID" value="B7C42_02595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="27266" checksum="06B9D757CFAB73A8" modified="2017-10-25" version="1">MATLTNDAVLAVAELLGVQTLPLVLEVGPRQDSIDAFTAARTEALRGLRGAGLVDRYDDVDPELGAALTILAQPECELAARIGTAAGVRRVSVVRRGAGHAVAVRTGDEIDVRTIWADEDGAALARPILDVLGPAEPADIAGFSAATDELAQRLDNATAATEFAEALHGLDVTERAAIEFGMALSRCHAHAEIVAYVHADGITTRSSGAVAVYDTARGRIAASPGAASDQRMWTTFTPGSDHRVAQAITALIGTLPGGRWMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9L2</accession>
    <name>A0A231H9L2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mshD_3</name>
        <name evidence="2" type="ORF">B7C42_02512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776618.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45387">
        <property type="protein sequence ID" value="OXR45387"/>
        <property type="gene ID" value="B7C42_02512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="177" mass="19190" checksum="B89DBD996BB37DF7" modified="2017-10-25" version="1">MSTESSPVVHIEPMGPADIARCVELELLLFPEDDPWQDVAFRSELAGSHNRYLVARDDAGRMLGYAGIALLGTADHPEAEIHTIGVDPDVHRGGIGTVLLRALLAEAGRRGGPVFLEVRTDNAPAIALYEKHGFHIIGLRKSYYQPSGADAFTMRRPAMTGFPHPGAERAHDSEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9S7</accession>
    <name>A0A231H9S7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783975.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45591">
        <property type="protein sequence ID" value="OXR45591"/>
        <property type="gene ID" value="B7C42_01883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18805" checksum="B4DDC554DF83D30A" modified="2017-10-25" version="1">MENKLTLDQMEELLAIHEMAEFNVDLDATMATLVDNPVYELPTLGWHIEGQQAVRELYKRLLHGGDIYNLWADKRVHATSPTSLAREAYVYIDTPDGRVTGQYFVAMDFAGDKIAGERMYMDTTFAQAMTDILGPDFADIPGVTPLPATVPTPRPRLDRAAAHAADSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9T0</accession>
    <name>A0A231H9T0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid metabolism regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fadR_3</name>
        <name evidence="7" type="ORF">B7C42_02687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45562">
        <property type="protein sequence ID" value="OXR45562"/>
        <property type="gene ID" value="B7C42_02687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="228"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="419" mass="45779" checksum="33F9ACA2678B731F" modified="2017-10-25" version="1">MVADRSEAGLASARPGTTPTTRRRPKNRKAQIVRVAARAFSERGYHPVGVDEIAAEVGISGPALYRHFANKYALLVAAAEAGAQQLLDAAEAADEPGLDPKSRLTALIRALAEHTIDVRREGGLYRWERRYLEREDRARIRVIYDELQDLIESAVAALRPEASPADVELIATGMLGVIGSITAHRTALSNARLTDLILDMSWSLLHTELPPLPDPAATGAPVRGLPLSSKREQLLTEAIRIFGRQGYHEASIEEIGAAVGINASSVYRYFASKSDLLAAAFHRTGERVAIANSEALAEATSRSEAALRIAARFARLTFSTPEILPVYFAEFSNLPAAEQQKLRSVQRQNVLEWAHLLDDDPAEARCRVHAAIAQVVDVGRRVRFENRPEHVARVCALMEAVLLGWNSAPEATEGEQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9V5</accession>
    <name>A0A231H9V5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">calB</name>
        <name evidence="8" type="ORF">B7C42_01913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784002.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45621">
        <property type="protein sequence ID" value="OXR45621"/>
        <property type="gene ID" value="B7C42_01913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="7">
        <location>
            <begin position="25"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="498" mass="52170" checksum="F5E71891F8E88DCD" modified="2017-10-25" version="1">MTMTAEPTVDVAPEELQRLLDAQRAAQALDPIPDAATRRDRIDRLVAAVLEHRDELAAALNADFGARPATTSLEVDILGGLPEIADTREELEAWMAPTEVPAAMGGAIPAFVQNRPKGVVGVIGPWNFPLVLVFVPAVEALAAGNRVMIKFSDMTPRTGAVFARAVASRMSPEEVTVVNGGLKTAAAFSDLRFDHLFFTGSPKVGRLVATAAGKNLVPVTLELGGKNPAIVAPDADVADAAARIAAARLFNNGQVCLSPDYAFVPAPSRDAFVAAYRQAVLTYFPTFADNPDVVSIVNDANYSRVTGLVADAKAKGATEIVIVPEGEKDRVPGPESRRLPPTLLLDTTPDAEINNEEIFGPVLVVHTYSDVDEAIAYVAAGEHPLSAYWYGGDTDDFQRFLVRTTSGGVSRNDFGLAYSNPAVPFGGVGMSGSGAYHGKAGFDTFSHQRPVASHDLPGGLAGALVPPLTPERVEAVAAAAAAAAAEVTARLRGSDGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA28</accession>
    <name>A0A231HA28_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitinyl-CoA dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">caiD_2</name>
        <name evidence="2" type="ORF">B7C42_02096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.149" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45804">
        <property type="protein sequence ID" value="OXR45804"/>
        <property type="gene ID" value="B7C42_02096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="28078" checksum="47DAE22C8D2C3C15" modified="2017-10-25" version="1">MADTPATDAPGTEAVLFDARADGIAVITLNRPATRNCLDAEIRAGLFAAWDRFEHDAALRIAILTGAGDKAFCAGGDLKEMVATGMQVPPRDMYPLPYDTIELSKPTIAAVNGAAFAGGWMIAQACDLCVAATTARFAVTEVKVGRSSPWAAPLIHMIPQRIMMELLLTGAPIDAQRAYEIGLVNRLAEPGRLLDAAIELAREILSGAPLSVRAARETVMLATEMGRAAALQAARAASERCYRSEDAQEGPAAFAARRAPVWKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA71</accession>
    <name>A0A231HA71_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase, short-chain specific</fullName>
            <ecNumber evidence="3">1.3.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45712">
        <property type="protein sequence ID" value="OXR45712"/>
        <property type="gene ID" value="B7C42_02004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004085">
        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="185"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="34079" checksum="7B89170320B1F94F" modified="2017-10-25" version="1">MTMDADEIALLTDSLRATMTGSTGDALDHALLDFGWLDLLTETPEVAIPLVFRLLGETGAHAPVLNDVIARAAGRDLPATVALPFTGGRWMMWERTVVAPSSPAATPVTAADPGPDPTGRAAPGPGGIQPDAVDPADRSTADARLDADGVSGGTDPTASQSFSAAPGLDPELPLRRVPAGETLPLAEGRRALAWWLAGTSRAMLNLARRHALDRVQFGRPLAAHQAVRHRLAETLVAIEGAEATLTTADTDLGALLAKAAAGHAARIAARHCQQVLGGIGFTAEHDFHRHARRALVLDGLLGSAAELTREAGAWVRTRAAAPRLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC0</accession>
    <name>A0A231HAC0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">(R)-benzylsuccinyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bbsG_1</name>
        <name evidence="9" type="ORF">B7C42_02102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.3" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45810">
        <property type="protein sequence ID" value="OXR45810"/>
        <property type="gene ID" value="B7C42_02102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033734">
        <property type="term" value="F:(R)-benzylsuccinyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="247"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="433" mass="48152" checksum="0FE778426604BE86" modified="2017-10-25" version="1">MAWDFETDPQFQHKLDWADAFVREEVEPLDLIWPHEQFVPPDPARRAVLDPLKQQVRDQGLWATHLGPELGGQGYGQLKLALLNEILGRSSWAPVIFGCQAPDTGNAEIIAHFGTEEQKRRYLRPLLEGELFSSYSMTEPQAGADPTRFTTSAVRDGDDWIINGWKFFSSNAATAAFLIVMVVTDPNVSAYQGMSMFLVPTDTPGVHIERTVGLYGEPLDGGAHALIHYDNVRVPDSALLGGAGQAFAIAQTRLGGGRIHHAMRTIGLARSALDMMCERALSRETAGSRLSDKQFVQGYIADSYAQLQQFRLFVLYTAWEIDKYNDYRKVRKDIAAVKVVMPTVLHDIAWRAMQVHGALGVTNEMPFFTMIHGAGVLGLADGPTEVHKGTVAKQVLRDHRPSEDLWPSQWIPKKVDAARAKFADHLEHEVGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAY8</accession>
    <name>A0A231HAY8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopimelate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lysA_2</name>
        <name evidence="4" type="ORF">B7C42_02285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45992">
        <property type="protein sequence ID" value="OXR45992"/>
        <property type="gene ID" value="B7C42_02285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="56"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="340"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="51609" checksum="9876E57FADAAFB9F" modified="2017-10-25" version="1">MSAPPALPALLHPLVRAYLDCPHALTAAVARFGTPAHLLFPQVCLDNLRQLRAVAMRHRLRHRICYAHKVNHSRALLATAHHAGIGVDVASAQELAAARDVGFAPGDIEVTGPKGRRLLRALAGSGVTVNVDNPWELRELTALADPSAPIPVLLRLSGFPGPGGQVAVSRFGIGPAEVAEQLTLLAHCRDRIILRGFAFHLDSGEIGERVRAVEACLDWIERAYAHGLAPTVLDIGGGFRQVFTADADRFDHYTLALRESMVGRGEPMSWAGNTFGYTVDDTGAHGIPVFHKYANTMSGPRMLDDLLAAPLPAHGGQPLARVLADNLLELWCEPGKALADHAGITVAGVEFVKRTADGSIVVTVDIGRDSITPADQEVMVDPLLLPGPESADRAAEDPGGPVGVYIGGHLCLERDLISNHKVWLPRLPQPGDLLVFPNTGAYHMDLSAARASMHPLPPKLAVTYRDDDFHVVPDADHRPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBA4</accession>
    <name>A0A231HBA4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative protease YdeA</fullName>
            <ecNumber evidence="2">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydeA</name>
        <name evidence="2" type="ORF">B7C42_01063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46099">
        <property type="protein sequence ID" value="OXR46099"/>
        <property type="gene ID" value="B7C42_01063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="22003" checksum="3ABE8EA7017E59FF" modified="2017-10-25" version="1">MSKTVHIAVYDTFADWEPSYVTAGINRPLMQREPGTWQIRTVGATAEPVTSMGGLRVVPDLTLDQLSPADSAMLVLPGADIWEDERLAPFAGAAAEFLSAGVPVAAICGATYGLAKQGLLDARPHTGNAPENLASTGYSGAGHYVDEPAVTDGDLITASGIAPIDFARHIFARLDLFEPAVLDAWYRLYADRDPSAFFALQAGAVEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBB5</accession>
    <name>A0A231HBB5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46102">
        <property type="protein sequence ID" value="OXR46102"/>
        <property type="gene ID" value="B7C42_01066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="16312" checksum="C62B95413538D2D8" modified="2017-10-25" version="1">MSDSDPAGRSDPRGDDPATSIDQRDTTRSAKPFLIAAAIAVLAVLAVVILGVTRPAENNLTEPDRVAIAARNFATARSDSDADRRKTTECAGFDEKKSPLGAGSVGKKVEIAGVDAVHIDGDHATASVTSRIDGHESAANWNFGRENGTWLVCGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBF4</accession>
    <name>A0A231HBF4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase</fullName>
            <ecNumber evidence="3">1.14.99.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ncsB3_1</name>
        <name evidence="3" type="ORF">B7C42_01175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.49" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46210">
        <property type="protein sequence ID" value="OXR46210"/>
        <property type="gene ID" value="B7C42_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="427" mass="46955" checksum="E3F6C8BA23761993" modified="2017-10-25" version="1">MTTPQSPLPEPYTTATGMCPVQHGSPFDADDDRFPMYTAEFVADPHAAYREMRGQYPSLVPVEIAPGVAATLVIDYAVAVRILNDPDHFPSDPRTWQKTIPQDSPVRPMMEWYPAARYNTGAAHARYRAPSVAAIDHIDLHSVPAIVERVAVPLVNSFCEQGSADLVMQYSFPLVLEVLNRMVGCPADIGTRVANGMAARFDTVRGQQGMDMLKEALMELIAFRREQPGDDVTSQLAHHPNGLNDIEVFAQLMSFYGAGFEAQRNLINNALMLILTDERFRFGDILGRNLSTTDALDEILFNDPPMANFCTTYPRQPIMIDGVWLPANQPVLISLAACNNDPKIRGEAASSIGNRSHLAWSTGPHACPAKSVAYLTVQNAIDQLFDALPEIQLAVPAAQLEWRPGPFHRALTSLPVVFPKSPPLPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBM9</accession>
    <name>A0A231HBM9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-hexosaminidase</fullName>
            <ecNumber evidence="5">3.2.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nagZ_1</name>
        <name evidence="5" type="ORF">B7C42_01195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46229">
        <property type="protein sequence ID" value="OXR46229"/>
        <property type="gene ID" value="B7C42_01195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375774" evidence="3">
        <location>
            <begin position="28"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="67"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="392" mass="40401" checksum="22CB2AD0627C539D" modified="2017-10-25" version="1">MRNVAGIVLAVAAVALAGCSGGGGSSSTTTTGPSAAPGTTNAAGGTAATTTTGNQQDCAAGYLAQFTTRQKLAQLLTVGVKNAADAEQVVRGEQVGGIFVGSWTDQSMLSGQGLDQVKAAARTPLMVTIDEEGGRVSRLQNLIGQAPSARVAAQTMTADEYYQQSLTRGQAMKKLGLTVDFAPDVDVSEEPDDAVIGDRSYSQDPQVVTEYAGAYIRAMHDAGVGAVMKHFPGHGHGSGDSHTGAVRTPPLDQMQQVDLVPFRNLIDSGAAVMVGHLDVPGLTSPNVPASISPEAMALLRQGTGYNAAPYDGPIFTDDLSGMAAITARMGIADAVAAALEAGADDALWISTDAVSSVLDRLEQEVRDGKLPMKQVDDSVLRVAKYKGIQLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBX6</accession>
    <name>A0A231HBX6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_01301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46335">
        <property type="protein sequence ID" value="OXR46335"/>
        <property type="gene ID" value="B7C42_01301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR46335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="455" mass="49268" checksum="FACE876D3685C92D" modified="2017-10-25" version="1">MADAIVRARATGRAAAAAAVLACAVTLIFAYLNKARCAGAPFDGDGRSLIFDRIKDAEVCYSDIQFLWLGRGIDEHLFPYVGGGITPDGTLTGGAVEYPVLSGLLMWLGAAGVHDDAGFLLHSALLLAPFALLTAWMLGRMSGAVALLWSVGPPLVLYAFHNWELPVVCTAVGAVYVMTTLTRYSLRTRGIGAAVLLGIGFCLKLYPGIFVLPLMLYIFLGEPDLGERPDAPRRGYDPAGAFAAAGAAIVTVAAINLPFALLGYDGWRASFTFQQMRQADITTNSIWYWGLRPMFPDGQSGEASFQDVVATASPVLVVVSFALAVWLGWKRFPALGYYPWVGVSAAMLSGFLLFHKVHSPQYTLWVLPFFVLLEVPWAAVGAYLLADLALGIGVFRYFHALGSGTGADFYEKLVQFGVWGRAILLVFFFFAFVRARPRGYRPMVSPEARELVPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCW6</accession>
    <name>A0A231HCW6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041768.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46760">
        <property type="protein sequence ID" value="OXR46760"/>
        <property type="gene ID" value="B7C42_01738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="24997" checksum="7F1FA09F17AF5C2F" modified="2017-10-25" version="1">MAGEPYRWVATGETDMVELRDPVSGRAVEIVRPSDDDLPAPLLREVETLVFDWANLLTQYEAWSDLHTLYRSEPDTVLWALSWLLALWAVVGETRTGKPADAIIRDLDYRGGWRDLRNAEDERIWTGLTQRVRLGGIAALTEDPRAVRAYHDACVEPADIGPILLRHTLIHLDALSQDMDRAGMRARGLASSVLDHTAPDPGPRRRLCFRPSRPGTDGLRDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCY4</accession>
    <name>A0A231HCY4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aliphatic sulfonates-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ssuA_3</name>
        <name evidence="3" type="ORF">B7C42_01758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775384.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46780">
        <property type="protein sequence ID" value="OXR46780"/>
        <property type="gene ID" value="B7C42_01758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011283832" evidence="1">
        <location>
            <begin position="26"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="121"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="475" mass="50476" checksum="BE8A5EF9DD40CC30" modified="2017-10-25" version="1">MKYRRARILAAAALIATLAAGCSLEQTGSGDTVRVVVGYQSKTINTVTAGTLLRAKGFLEKRLNDLTAKGGPKYQVEWQDYDTGAPITAQMVAEKIDIGSMGDYPLLINGSRTSASERSATELVSITGYQPRGSLNMVVTAPNSTATTLSDLAGKKVSASVGSAGDGTLRQALSRANIDPAHGVDVLNQQPQIGASALESGQVQALSQFVAWPGLLVYQDKAKLLYDGAELNVPTFHGVVARRDYSKSHPEVLDAFLQAQLDATDFLHAKPLEAAQLVADNSGLPAEVVYLYNGPGGTSFDTPLKPQLVQAFKGDVPYLKSIGDFADFDIDKFVDDAPLRKVFAERGANYDAAVANFANPAPITGTDPSTGKPVSDPALAGEIWFDGQSTAQPAGSPTDLLRAVKAARAQGKKIRAAYVPDAELGTRWFADKAQWVREGDTYLPFITPSAVQRYQARHPGAVAVSYDQAIGEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD08</accession>
    <name>A0A231HD08_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46863">
        <property type="protein sequence ID" value="OXR46863"/>
        <property type="gene ID" value="B7C42_01841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="30542" checksum="7AF88D13D4935E42" modified="2017-10-25" version="1">MSQSSAAYPSVVPVGVDTARASIARVYDAALNGKDNFEIDREVLAQVRAVAPQVNDLAWANRDFLIRACRFLAAQAGIDQYLDLGSGLPTAENTHQVVQRIRPEARVVYVDNDPMVLAYARALLEANAQTSIVACDIFRPHEVLTDPTVRDDLDFSRPLALFQIGTLQHYLDDDAPALMQTYIDALPSGSYVAIAHFYDPEDSGPGELARKMEDRFVHSPMGSGRFRTREEIQALFGGLEMIEPGLVLCDDWWPDGPRLTPLSDVRQCILGGVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDA6</accession>
    <name>A0A231HDA6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46707">
        <property type="protein sequence ID" value="OXR46707"/>
        <property type="gene ID" value="B7C42_01683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="29566" checksum="C1DF056C3E27370D" modified="2017-10-25" version="1">MADDDLHDFEHATFTHEGKSRTIFRQGSGPAVIVMAEFPGISPDVFDFARRVARIGCTAVVPHLYGNPGRDPDPAAHGTLAAVANIAGQFGPICVSREFVVLATGRTSPVVQWLRALAEAEHRRCGGPGVGAVGMCFTGGFALGMAVDDRLVAPVLSQPGLPLGFTARQKSSIDVSPGDLDRIKQRCAAGLSVMGLRFRGDRRSPAERFDFLRAQLGDAFIAIELDDAAANPDGVLSAHSVLTEHLIDEPGEPTQAALHRVLDFLAERLEVPGRVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDB3</accession>
    <name>A0A231HDB3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46786">
        <property type="protein sequence ID" value="OXR46786"/>
        <property type="gene ID" value="B7C42_01764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="506" mass="53445" checksum="E2E30B56CD6633EB" modified="2017-10-25" version="1">MSIITDVKLSEAGLLEVAETVKVPPGGQFHMALPLRVGRDDGSERRFGVTDISSTGPGSAKVTGDVFSVDAPPGESSFKYTVHGTVSDAPGTQLFHWTGVLNTDVASFDGSVISPSYQMGIADCTVGSVGSTRKCNDARVEPDGVLTMHEENLHKGDILDVTLQVPPGTVKANADIRGGRGSGAFAVTAPVLIAFGVLLAALAAFGAYLARSRRQDAAALTSTSTLDPVQRNGNHSEFVSPDGILPGEAGLLLDGSADAADIAATVVDLAVRRYLWIAAVSDSDWRITRANPADDHLRSYEKHVYTTLLPEGADSVLLSELRAPGRVAAEPVRSALRRDALERGTLIDHNRRGLAFWIGIALLVVGLGATVGLAVAGGYALVGVAIALGGAAILLLGRYLPVRTAAGRALAAQVKALQNGLDAQRPDQIPPADRELLFSRALPFTIIGGRADNWIRTFRDVDPGADRQAGLYWFGGFDRDRNLHRFAGHFPYFITALEGLFTTSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDB5</accession>
    <name>A0A231HDB5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tyrA</name>
        <name evidence="2" type="ORF">B7C42_01693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46717">
        <property type="protein sequence ID" value="OXR46717"/>
        <property type="gene ID" value="B7C42_01693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="308" mass="32335" checksum="B6464AF3D361EEDB" modified="2017-10-25" version="1">MCVLGTGLIGGSLLRAAAAGGYRAWGYNRSAPGAQAARADGFDVESDIAAVLSRAAADDALIVLAVPMPAIDTVLADVKTFAPDCPLTDVVSVKEPVRAEVHRQELGARYVGGHPMAGTAESGWAASSPDLFRDAAWAVGVDPGTRAEPWHRVARLALDCGAIVVPVLADEHDRAVARISHLPHVLAEALAVAGAAGGDLALGLAAGSFRDGTRVAATAPELVRAICEPNAAALTEAIDDALRLLEAARDSLRDEGTLGELIDAGYSERDRYDTLRRWDITDIRPGDQDWLERLRDAGRRGGVIRSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDD0</accession>
    <name>A0A231HDD0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmgC_2</name>
        <name evidence="9" type="ORF">B7C42_00079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46963">
        <property type="protein sequence ID" value="OXR46963"/>
        <property type="gene ID" value="B7C42_00079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="143"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="246"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="42301" checksum="C3BF07C26F06DC75" modified="2017-10-25" version="1">MTNRCSAEARGPAPRPERTVVTFTPTDEQRELQRLVRRFCEEKSPITEVRRLMESDSGFDTGVWDQMGKELGLQSLHIPEAYGGMGFTVVELGLVLEELGRALLCVPFLSSVVLAANAILAAGDEEQRRSLLPGIAAGEVRGALAFAESTDTWAPEAVATEAVADSDRYRLSGAKTMVVDGHTAHTLVVSARVPAGTGREGVSLFIVDCDDAPGMTRDAMPTLDQTRKLATVTFDRTPARLLGSEGSGWPALERTLQLAAVALASEQVGGAARCLDMSVEYAKVRQQFGRPIGSFQAIKHRCADMLLDVESARSASYYAMSAAAENVELPLAAALARAHCSEVFSRAASACVQIHGGIGFTWEHDAHLYLKRARGSEALLGGIGHHQDLVAAGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDI6</accession>
    <name>A0A231HDI6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxocholest-4-en-26-oate--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.42" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46856">
        <property type="protein sequence ID" value="OXR46856"/>
        <property type="gene ID" value="B7C42_01834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="441"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="537" mass="58791" checksum="B2C593FF165AA2B5" modified="2017-10-25" version="1">MPNNFADLFEHAVDAMPDRVALIQGERQVTYQELERRANQLAHHLAAVGLGEGSHIGFQMHNSIETMETLIAAFKIRAVPININYRYGADELRYVYDNADLEAVVHHRCYAQVVDQVRPQVTTLRHAFVVDDDQGGDGLPSESTPYAEAFENSSSARDFAERSADDLFMMYTGGTTGMPKGVMWRQEDMWRVLGGGIDFYTNVPVADEFEQSRVGSQNDPLRWLILPPLIHAAALMPTFTALWSGNTVVYEPRFDADRVWQVVATRRANIVVITGDAMARPLLNSYRQSPVDASSMVALASGAALLSQPVKNEMLELFPHAVITDSIGSSETGFGGIGVAQKDDDPSRGPRVQTGRGAVVVNEEGREVAPGEEGWMAKKGAVPLGYYKDQTKSDKLFKSVDGVRMVITDDRARVEADGTITLIGRGNMVINTGGEKVFVEEVEAVVKAHEGVYDVVVIGVPHERWGHQVAAVVSVAGADPLDFADLEAHVRKHLAGYKLPRSIWVVDAVGRTPSGKPDYRWAKGHAESHPPAYTVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDV9</accession>
    <name>A0A231HDV9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Terephthalate 1,2-dioxygenase, terminal oxygenase component subunit alpha 1</fullName>
            <ecNumber evidence="8">1.14.12.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tphA2I</name>
        <name evidence="8" type="ORF">B7C42_00168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.15" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776969.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47049">
        <property type="protein sequence ID" value="OXR47049"/>
        <property type="gene ID" value="B7C42_00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018628">
        <property type="term" value="F:terephthalate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="54"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="42911" checksum="E718DC98D093E3F6" modified="2017-10-25" version="1">MDRQALEHSLARRLLDHIDAGTTDLAPDILELPTDIYSTQRHAEEFDVLFRGHPLVLCLSGALPHAGTYRAVDLCGVPILLTRNDEGRVRAFANACRHRGVRVVDGGGARSRFACPFHSWTYDLDGRLVAVPVQDAFTGMCLERKGLVELPVAEGYGLIVGSLQPGPTVDIDEYLGPGLADELAVLEFADWELYGEPHVHPVGANWKVTLDTFRENYHFRFLHRRTLAKYAYGGVLTFDPFGRHLRNCSALRTIDELREVPDEQWGDVMGHISLQYALFPNTSLTFDSRHVELWQIVPVDANSSEVVHSTYLRPGLSESERAKAVEMAPWICETVVDGEDFWVAARTEPGIRAGVLDTIVFGRNEPAPQHLHRGFDDALAAARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDY7</accession>
    <name>A0A231HDY7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bmr3_1</name>
        <name evidence="8" type="ORF">B7C42_00273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47151">
        <property type="protein sequence ID" value="OXR47151"/>
        <property type="gene ID" value="B7C42_00273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="492" mass="49940" checksum="97799FD28280B6C6" modified="2017-10-25" version="1">MERRGSLLTGVLAFAAMIVTVMQTQAVPILGLIATKLQVSTTSVSWVTTATLLSAAVFTPLLGRIGDLYGKKPTLLGVLAVATAGSVVSALANSLGVLLAGRVLQGVATAIFPLALAVLREEIPARRLHHAMAIVSGTLGFGGGLGLVSTGLLTKGTDPDYHIVFWFTAVLSVVALAAAAVAVPATGKRHPGSVDLPGALTLGGFLVLLLLPISQGHEWGWTSATTIACFAGAVATAVAWVVTERRVRTPLVDLPMFTHRPVLFTNLSGMFIGFAMFMQFMGVSYLAQMPSRVAGYGFGASILRASVEYLLPATLSSMLAAPAGGILVGRLGGRRVLALSGAIGAAGFGGLALAHDATGSVIAASVVIGVAISFAYAAMPALIAASVPHHQSGIANGINSISRTVGSSLASAIITTLLTAKLLPHLPLPQESQFTIAFWVGAAACAATVLAALFGLRPEGHGAGTDGGELGAAETGSGTVSFERPELPSRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDZ5</accession>
    <name>A0A231HDZ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46927">
        <property type="protein sequence ID" value="OXR46927"/>
        <property type="gene ID" value="B7C42_00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="9528" checksum="D238F9E3B974612F" modified="2017-10-25" version="1">MARTGRPRSGPDLVVTEAQRRELVRGARAATSNIADGTVIGELHRRHRATEFRKLLTSIDNAVPAELDVHVVCDNCDGDRVPSRVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE74</accession>
    <name>A0A231HE74_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47241">
        <property type="protein sequence ID" value="OXR47241"/>
        <property type="gene ID" value="B7C42_00363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="183"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="413" mass="42881" checksum="BAF0A6EC7DEFB95F" modified="2017-10-25" version="1">MSSERSSDDRDEPVRQVSDELLRKASEGPVRRLPDALFGGPVAPVEPAGESDAAAESGDAGDDGGSTGPPAVLSDAPAAAEQNAEPAEDAREDSVTGGSETTPSTATHAVSGDATVSGDDDAHRKSGAGSGAATPGEPTVSSAAVDAVSGIDDAVSADALPSIGDAAGAPEGSARPVLVVIADSLSYFGPKGGLPADHPRIWPNLVAAELDWDVELVARIGWTCRDAYWALIGDPRVWAAVPRAGAVVLATGGMDTLPSPLPTALREMIRYLRPPVLRRQVRTGYQWLQPRLSKLGRPVALPPHVSIDYLEQSRHALAQLRPDLPVVSVLPSVHDCEAYGKVHSGRAPAVRALQEWSAKTGVPLVDLGEAVRDDIFSGEANPDGIHWGWEGHAAVARAMVKVLSEVRSVEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEA2</accession>
    <name>A0A231HEA2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47096">
        <property type="protein sequence ID" value="OXR47096"/>
        <property type="gene ID" value="B7C42_00218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="8670" checksum="A0B5554EB9C3364E" modified="2017-10-25" version="1">MSKTGRTNPRRADREAKRRKASSRGERKITVRSEKRTPPDLYKLSRAVIAIALAEADADADTKRARGKREEDHHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEP4</accession>
    <name>A0A231HEP4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47278">
        <property type="protein sequence ID" value="OXR47278"/>
        <property type="gene ID" value="B7C42_00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18917" checksum="7F8BBFB55B44D10B" modified="2017-10-25" version="1">MGADTTPSPGLLTSSLTEAQNGNLSVSFGDSIRVSADEFVYIERDCIAFKEEIRALQRLAQNISRREKWGLGEFTEGLESSKVLVGWFRGKAKIVDASKDTSNNVWDILEQHYQIVDQLQQLHHVIAQKYVETDQEFAAEYNALMANTPASPIGKVQIQPGVVPQSPAVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEQ4</accession>
    <name>A0A231HEQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amicyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mauC_1</name>
        <name evidence="4" type="ORF">B7C42_00492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47369">
        <property type="protein sequence ID" value="OXR47369"/>
        <property type="gene ID" value="B7C42_00492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13921">
        <property type="entry name" value="Amicyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035668">
        <property type="entry name" value="Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257569" evidence="2">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="3">
        <location>
            <begin position="73"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="16013" checksum="0D9CD8DAF1C022C2" modified="2017-10-25" version="1">MHRHLVLNGTAAAMAALGVMTLTACATSADKGTSPPAPTLRSDDPGLGMTPGAPAPMPDMPGMSSAPRAPAVAAGPNAVTIDNFAFGPQTVSVKAGTTVTWTNRDEEPHTVVARDGSFHSPGMGTGATFSFTFAQPGTFAYFCSIHPFMHATVVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEY7</accession>
    <name>A0A231HEY7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47295">
        <property type="protein sequence ID" value="OXR47295"/>
        <property type="gene ID" value="B7C42_00417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="30306" checksum="E6613170F97612A0" modified="2017-10-25" version="1">MSHELVEFDTDKAHSARMYDYYLGGKDNYPADREAASKVMEAFPETAQAARANREFVHRAARFAARNGVRQFLDIGTGIPTEPNLHNAVQAVDPHCRVVYVDHDPLVLAHARALMIGSEEGRTEYIPSDVRDPEVILGSERFRAVIDLSRPVALNLAAIMHFVTDEEGAYDIVRTYMDAFAPGSYLSITHASSDVNPERLAKVAAVYAQAGMKVALRNKAEVTRFFDGLELVEPGVVPMHRWHPNPDFYIPEERLAWADEAFGIWAAVGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF58</accession>
    <name>A0A231HF58_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503669.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47514">
        <property type="protein sequence ID" value="OXR47514"/>
        <property type="gene ID" value="B7C42_00639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="10872" checksum="F5C2A3A00D29572C" modified="2017-10-25" version="1">MANEVVSSSMITSDSTHHIARCVGGDHWVVSWLPGRTLTGGQAVAAMKLAGALVDGTPGDSDWATLDAMALPLGLTGREAVYLVAYEQHDFSRAPRPRHSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFT3</accession>
    <name>A0A231HFT3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxosteroid 1-dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kstD_2</name>
        <name evidence="5" type="ORF">B7C42_00935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.4" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47810">
        <property type="protein sequence ID" value="OXR47810"/>
        <property type="gene ID" value="B7C42_00935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047571">
        <property type="term" value="F:3-oxosteroid 1-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="14"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="569" mass="59823" checksum="955D2F13FA1BD1A8" modified="2017-10-25" version="1">MNSSENHTAAQEVDLLVVGSGTGLAAALTAAEAGLSVLVVEKSEYVGGSTARSGGAFWVPGNFLLREQQPADDARAAAAYVEAVVGDSAPRERGAAFLEHGPAAVEMLARTTPMTFMWADGYSDYHPELPGGSAAGRTCECKPFDASQLGAHRSRLRPGVMEASGLPMPVTGADYKWLNLIARTPRKALWRGMKAMAIGVGGLAFKREYIAGGQALAAGLFAGAIRAGIPIWTDTSLVRLLVGEDGAVTGAVVDRDGVRTEVTARRGVVLAAGGFDHDTEMRRKYQSDRLVEHASLGCETNTGDAITLAQEAGAAIGLMDQAWWFPAVAALPGGQPAVLLAERALPGSFIVDQSGRRFVNEATDYMSFGQRVLERERAGDPVEQMWLVFDQRYRNSYIFAAGLFPRQPLPQPWYDNGIAATATDPASLARAMGVPADAFAATFDSFNAAAELGVDHEFARGASAYDRYYGDPTIGPNPNLRPLGSKGTLYAVKLVLSDLGTCGGVRADGSARVLREDGSVIQGLYAIGNTAANAFGNTYPGAGATIGQGLVFGYIAAKTAAGHHSFQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFT9</accession>
    <name>A0A231HFT9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">dxr</name>
        <name evidence="11" type="ORF">B7C42_00711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779634.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47586">
        <property type="protein sequence ID" value="OXR47586"/>
        <property type="gene ID" value="B7C42_00711"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="254"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR47586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="379" mass="39641" checksum="628FECAB0ACF5E4D" modified="2017-10-25" version="1">MSDIVKVLLLGSTGSIGTQALEVVAANPDRFQVVGLAARGGNTDLLAEQIRATGTDNVAVADPAAAAKLGVALAGPDAVTELVRRTDADVVLNALVGALGLRPTLATLESGRRLALANKESLVAGGSLVTRAATPGQIVPVDSEHSAMAQCLRGGRADEVARLVLTASGGPFRGWTTEMLESVRPEEAKAHPTWSMGLMNTLNSATLVNKGLELIEAHMLFGIDYDKIDVTVHPQSIVHSMATFTDGSTLAQASPPDMKLPIALALGWPDRVPGTLAPIDFGTAFTWEFEPVDTEVFPAVELARAAGKAGGSVTAVYNAANEIAVQAFLDGALRFPDIVRTVARVVESADRWAAEPSTLDEVLAADAWARQRARTLVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFZ6</accession>
    <name>A0A231HFZ6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47738">
        <property type="protein sequence ID" value="OXR47738"/>
        <property type="gene ID" value="B7C42_00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012917924" description="DUF218 domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="68"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="21093" checksum="A1962F3C01C2499F" modified="2017-10-25" version="1">MPGFRTSLRPNGFRFLAAAALAVGALTAVAFPTAAADPLTDAAGVIEQLRAVGDPLPPLPAPHGPTTAIVVLGYGLLPDGGMRPELVARLQAALVQAMVSPASPIIVTGGNPRGGTTEADAMAGWLVGHGISPERIHIESRASDTVENAVNSAELMHILGAGDAVVVTSADHMPRAVADFVDAGVLVVGTVSPQDLPPVVLEVFGPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG81</accession>
    <name>A0A231HG81_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">bcr</name>
        <name evidence="10" type="ORF">B7C42_00963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47838">
        <property type="protein sequence ID" value="OXR47838"/>
        <property type="gene ID" value="B7C42_00963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="22"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="446" mass="45474" checksum="503D19D2341870F5" modified="2017-10-25" version="1">MTSSIRDAGRVSPGEGAGRTRLVLILGLLTALGPFTVDMYLPALPTITRHFHTTDTAVQLTLTGTLTGLAIGQLVAGPLSDIYGRRKPLVAGTFLHVSASVACFFAPSIAALGAFRTLQGLGAAATGVIAMAVVRDLFTGRAAAVVLSRLMLVMGVAPILAPSVGGLVSGAISWQGVFLVLAVLGAGMMALGGCALPETLPPDARAGRGISQVLNGYGRLIRDPQFVVLVLVCGLGRSVLWAYIAGSSFVMQGQFGLSSVSYGFAFAAGGVALIGASQVNVALLTRWSPLRISLVSLLVSTIVGGGFVVLSALRAGGFPGFAVPVLVLLFATGFVMPNAPALALSRHGGVAGTAAATVGFAQFGAAGVVAPIVGLLGNTSLAVAITMTAAATLAFTVLALMSISRRERPRARGQDGQNVVRSGPVWATEPAHPVARYHAPTDRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGJ7</accession>
    <name>A0A231HGJ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47837">
        <property type="protein sequence ID" value="OXR47837"/>
        <property type="gene ID" value="B7C42_00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012669325" evidence="2">
        <location>
            <begin position="48"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="27439" checksum="8FBF8E933CF30AA3" modified="2017-10-25" version="1">MRNMLHISGSASSNCARRSLRIGARRGIGTATLAVAALMCATNVANADRTAGSPVAPEINYTAQIRDQSVFFSTDVGSLAVRGERLDVLDPEGNEVAAIPLTYRMNNLEHRISAVVTDRTVVLTPSVDPTAAVPSPDVPRADVLPIDDALEHVAATYPSPDARSADALGTLVQQVTVASMLSGMIGTIVGAGIGCVAGLVVGTAATTPVAWLLGAGPIAGCVGGAVLFGSIGAIGGTLLVGGPITVGALFQYFQTMNAPIVPAETQQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSK9</accession>
    <name>A0A231GSK9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000129">
        <property type="protein sequence ID" value="OXR39620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39620">
        <property type="protein sequence ID" value="OXR39620"/>
        <property type="gene ID" value="B7C42_08312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="7476" checksum="BC1920AECAB108A7" modified="2017-10-25" version="1">MDTPLRVLADDVTTWRALTDVFAEHLPGIPIDGKAPEAAAVSLNTILEYIPGGAPALQADLQAALHTAGKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSL6</accession>
    <name>A0A231GSL6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000139">
        <property type="protein sequence ID" value="OXR39614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39614">
        <property type="protein sequence ID" value="OXR39614"/>
        <property type="gene ID" value="B7C42_08318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7521" checksum="B70D74A1950069AA" modified="2017-10-25" version="1">MGVIAADAIDIISGERDGKLALCGSPTCRAAFFDTSQSRTRKWCDMNTCGNRQKKARFNATHRKKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSP6</accession>
    <name>A0A231GSP6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000105">
        <property type="protein sequence ID" value="OXR39644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39644">
        <property type="protein sequence ID" value="OXR39644"/>
        <property type="gene ID" value="B7C42_08287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="362" mass="38792" checksum="2385E05B92E8D85C" modified="2017-10-25" version="1">MVAAAGEQHQIVGGHVVDGVGGGQPVENARCDGQFTGAAGRRAVDPRQGPCRAHAAGGRALDAEVFAAGGTFGRAGAGAAQGAIGQSAPQKHLNRDAQRHVSLVPQHVQPGGGRQRGDAIEGLFLRQSDEEVQLERAGEVLGEDAAQAAVARIDAAEQFALVQPGGDRVITLPGARAPQWLLVGQDLREPIPVGHIRQPHHPIQHRQTRAVVEQLPHGDRFLAVRGEFRPVLRDRRLVVEHPTRDGTRHGECRHPLRRGEDRNHGVALPRQLSAAIAEPRPQIHHRPVPVVDGHGRADLAESGEVASKRVRDRLETARHLTVYLSNLAHSATDGNGHRCGVVRCPPGSETDQAAWIRELSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSW6</accession>
    <name>A0A231GSW6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000079">
        <property type="protein sequence ID" value="OXR39719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39719">
        <property type="protein sequence ID" value="OXR39719"/>
        <property type="gene ID" value="B7C42_08207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="505" mass="55524" checksum="C2536883287B69BA" modified="2017-10-25" version="1">MVRQIAGGATGQSQMLGRLAPLMMIPGEAWLAIIFPDGEEQWHVLSNDEVKPRGELVELELEDGTNYTMDPETDTLSRIWRQDPRRARLAWSPAKAALPILKEIVRMSQNIEAAGKSRQAGNGILVLPTEISMPAKPAPTGAPDPDAPNLPAPAPLSRFVTADEVRVALQEAMAKAIQDPSSAEALVPIILQVAGEWVDKIRHIKFDSEVSDKAQAAREKAVRRLAMTLDMPPEVLLGLADLNHWSLYGVEEEAVRWHAAPEMETICAALTTQLLRPMVPDADVVIWYDTSDVEAEPDQVEKVRTGFTDGVVRAEAYLRELGMSEEQDGYDLTTREGWTAWVLDQVRKDAALVPVLEPLLRTLVPALGLPELKPAPAAPPTPPPPAPELEQQRVPDTREQLAAAADTAVRICVNHAMKLAGNRRRTRPNHTQLQGIPPRDMHLKQHLGPCQPAEVDRLINGWDEVLDDEICATAGVSRDKLQALVASVCREALTTGTHPIWRSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT24</accession>
    <name>A0A231GT24_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000068">
        <property type="protein sequence ID" value="OXR39773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39773">
        <property type="protein sequence ID" value="OXR39773"/>
        <property type="gene ID" value="B7C42_08158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="299" mass="34502" checksum="CC0D879A9DAC74D1" modified="2017-10-25" version="1">MTTSSQPAARDQVAARLIEGSVRRSHNSLLEIDWDAPQDPDLFYMPPELVTLYGTPLWESMTHRQRVELSRQEVANTFSRAVWFENTLNQGLLRAMLHQDPTSAHVHYALTELGDETRHMVMFGKMISAIGAEPYRLSLIQALTVQAMPLFYRGLMLYLAALCGEEVIDDVQRKFLRHPDLQPIVAQTMRIHIAEEARHIRFAREGVRRHARRASWPVKTFCATANGAAAFILDRMFMDKRAYERCGLPVAEAVRQARANEFNRIRRRAAFADFHAFLEDNELLNPVSRFMWRRYGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT73</accession>
    <name>A0A231GT73_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39820">
        <property type="protein sequence ID" value="OXR39820"/>
        <property type="gene ID" value="B7C42_08108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="7488" checksum="958EBBB3C57F7567" modified="2017-10-25" version="1">MSDRSRYPDPTPRELEWHHNRCRKGWLSPWNAPHPIPCLVCKPHLRRTLATNDCDPNAPYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTL3</accession>
    <name>A0A231GTL3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent RecD-like DNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">recD2</name>
        <name evidence="5" type="ORF">B7C42_07963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39956">
        <property type="protein sequence ID" value="OXR39956"/>
        <property type="gene ID" value="B7C42_07963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043764">
        <property type="entry name" value="DUF5710"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18974">
        <property type="entry name" value="DUF5710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="944"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="353"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114892" checksum="5FC57BB06A5A423A" modified="2017-10-25" version="1">MSESKRPFPIDELLRAVELEVVTARRSEPRDGVKVSLSAGRVVSSAAERYEYLFTCKKWHRSLDTAAVLVRPSTSRGSWMPAEAARLPDGTVRLVTAESLGTVPLNVQLREDDSTGFTRAIERLESAADDDALHLETAGWVVGRGEPRSGIDDNPSRWVANWPALKLNSRQRIAVQRSLASEVLFLWGPPGTGKTDVVGHVVEGNFRQGRTVLFLAPTKVAVDQALERICDLLNNEAGFSDGLIQRAGDIEVGTLRARYGSSIDPEQVIDRVTVELDEAIAQSTEAWTRAQTQLRLYDDAGSLLERLHNARSAKKDAELERIRAGQDYRKADADAQKFQEKLIRVTPPRGMFADRKEGRIAALRRDLADAEGQRQRAAQQRQAAEDAIAQSAGEIDKAEHELAAVTSILENIEPHPTLVDRAEGLRKQLDELNQQRAKIRQAVRGRCRIMGTTIAKAIQSRRLLDRIDVVVIDEAGMVDLPSAWLAAALARERVVIAGDFRQLPAVTKADSDRKASDDDRAHARMWSSRDPFRASGLVTESGTVRDDPRLVALDTQYRMREPICDLVNAVAYPDAPLRTGRNNTSRIPANPLVETPMILIDTSRQRIPNRQNQSNTVHEAVIHELIRGLQYEGVLPGRKWQESEVAHGSRPTDRLAVITPYRKQVKALQSSVKYRFGTDYDALVDTIHRFQGSQRPIVIFDTAAGAGSDPGYFYTGSGLSSQTCRLLNVALSRAQDHLIVVADVDHLRQHLPAHSEARVMIEHLENHAQVLSADQLVPIREAAQLSELSEEELRRPAFFPADEVEKAVEWDIARAVTSVELYCPFLDPVPVNKWSKRLGERAGAGVRVVVYTRSVEEQRDPPAAERHRARIEQLRSAGCAVDFRERMHEKVLIIDREILWHGSLNLLANSGPTDLMMRFTDPGACERVGTVIERARKDRAARNFTAPSNSDFGQQTLRTPVTSGGAGPDEREVVPGTVVNGRLYLAVGYDEKDEAKRLLRARWDRTNKLWYVDSERVTREQARRWLPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTV4</accession>
    <name>A0A231GTV4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetoacetyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.1.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phbB_2</name>
        <name evidence="1" type="ORF">B7C42_07928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.36" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000046">
        <property type="protein sequence ID" value="OXR40008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40008">
        <property type="protein sequence ID" value="OXR40008"/>
        <property type="gene ID" value="B7C42_07928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018454">
        <property type="term" value="F:acetoacetyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="27290" checksum="2F20FD6E3216500E" modified="2017-10-25" version="1">MAESTKGELVFELDGRIALVSGAGQSVGEGIATVLARQGATVVVNDLHAERAERVAAAIAEEGNKAIARAFDVTDYQATVDAVRSAEAELGGHVNILVNNAGIAEKRVAKPFRELTPDQWPPSIELNIYGAMNCIKAVIDGMCDAGWGRIVQISSGSARTGQNINVSMYATGKSGIEGFIRHLAAETGQYGVTANIVALGLQANLVEKMAPEYLERLIAGIPIGRLGDPIEVGAFCAYLASNEAGGMTGQTLDFNGGSQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUG9</accession>
    <name>A0A231GUG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40274">
        <property type="protein sequence ID" value="OXR40274"/>
        <property type="gene ID" value="B7C42_07699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="19607" checksum="15D967ABFD445461" modified="2017-10-25" version="1">MEYVSVCNEILMNSVDIKGAFNAFRDMVFNRAGAPDPKAGDKIDHALKVAEENKRIVEPYNRLRMVAPNNVIDAAVKLNAAMLAVLKATTEPLAQPVTRKAAADEMENFINVFRAEVGKEQYTASEAHEKTISFLANLKRQVNDYVKESREEMRAAGFPSTPWDDMKENPMSDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUP2</accession>
    <name>A0A231GUP2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40288">
        <property type="protein sequence ID" value="OXR40288"/>
        <property type="gene ID" value="B7C42_07626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8780" checksum="F3998217A5381884" modified="2017-10-25" version="1">MPSANSVPTLSRAEFDRLEHRGAAGTTVVLAEMDSAAADRWRDEHTGWRGRHWAYLDDEHGVLRLHPINVTRTSSQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUX5</accession>
    <name>A0A231GUX5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-CoA:(R)-benzylsuccinate CoA-transferase subunit BbsF</fullName>
            <ecNumber evidence="1">2.8.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bbsF_2</name>
        <name evidence="1" type="ORF">B7C42_07487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.15" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778557.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40429">
        <property type="protein sequence ID" value="OXR40429"/>
        <property type="gene ID" value="B7C42_07487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033877">
        <property type="term" value="F:succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="781" mass="84374" checksum="C9360E509DF985B8" modified="2017-10-25" version="1">MGNSAGDTRLLSGLRVVESSRTIAGAYAGKLFADLGAEVLLAEPADGHPMRSANGSDQPSPLFSFLSAGKCSSTRHWRELVEAADVLVLETEGLPDLEELRRLARARVVVAVTPWGLAGPWAEAERPWTEFTLQAEAGSLSNRGNPHSYPVALGGSETLWVAGSLAATAAMGAVAGLDRSGVGELVDVSLLEATTYAATMFGDLRATIAGERPEQVSLRRPLLPSVEPAADGWVGFNLASAQNLEDFLVLIDRPDWLADEDMKTPEGRYRRGAEFSAAVRAWTRQHTVAEIIETASLFRIPCAPVHSAATILGDEHVRARDFYIDDATSRFRQPAVPMLFNGIRPGVGKPVSAPADVGFEGEPDRGRASATTEDDLPLRGLRVVDFSNWWVGPLVGTVLGSLGADVIKVESTRRVDGSRMLGGSATSRPDWWEYSWVYLGANHNKRGITLDISQPEGRELFERLIADADVLLENFAPRVLENVGLDWAAVHEINPSLVMLRMPAFGLTGPRRDMVGYAQTVEQYSGMCWRTGYPDGPPMNPSGPADPMGGSNAAFALLAALYRQTRDGSGLLVEAPLVEAALTMTAEQVVEFTANGRLLERDGNRSRGHGPQGVYAGAGTEQWLAVSVITDDQWHALAGYTGIAGWADPELSTSDGRWRHRDRLDADLAAWTAGRNVAATVADLIALGVPAAHVVDQRFVHAHPQIAARSYFEDIHHPARGTMPIPVLPFRFGRIPRWSRIAPPTVGEHNQEVLERDLGLSVERIRELAAKNVVGTRPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV82</accession>
    <name>A0A231GV82_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenylacetone monooxygenase</fullName>
            <ecNumber evidence="6">1.14.13.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pamO_2</name>
        <name evidence="6" type="ORF">B7C42_07513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.92" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778541.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40455">
        <property type="protein sequence ID" value="OXR40455"/>
        <property type="gene ID" value="B7C42_07513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033776">
        <property type="term" value="F:phenylacetone monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="541" mass="60068" checksum="F0244C9FAA6129D8" modified="2017-10-25" version="1">MTEGISIDRRRSVDVVIVGAGFAGLYAIYRLRGQGLSVRCVEAAEGVGGTWFWNRYPGARCDVESIDYSYSFDPSLEQEWDWTERYAAQPEILRYLEHVADRYDLRRSITFGTRVIAARFEEEIGHWLVELADGSTLTARFVVFATGTLSAVHAPNLPGLETFTGRTFHTARWPHEDVDFTGRRVGVIGTGSSGIQIIPILAERADHLTVFQRSANFSIPSPNGPHTAETRAAYRASYAERRRLSWDSGGGSPHRPHDKGTFEVSEQERLEIYERQWQLGGVLFSKAFPDQMNTDEANAPAREFFAAKVRTMIEDPALAAKLIPTDHAIGTKRICTDSGYYPTFNRPNVALADLREAPIDEVTPTGVRRGDIDHPIDDLIFATGFDALTGALAAIDIRGRAGHSLRDEWAAGPRTYLGIEVAGFPNMFIVNGPGSASTFTNMVLSAEHQVDWIGDTITHLDSRNLWGIEATSSAQDKWVRHCAELAENTLFPRANSWYMGANVPGKPRVFMPYLGGFATYRKRVAESVAEGYRGFALLRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVB3</accession>
    <name>A0A231GVB3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40577">
        <property type="protein sequence ID" value="OXR40577"/>
        <property type="gene ID" value="B7C42_07386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014529">
        <property type="entry name" value="UCP026631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026631">
        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="475"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="574" mass="61886" checksum="762B318A048844AC" modified="2017-10-25" version="1">MSDSPAGVAADEWRRLDMRMLLVHPVRELFKYIPVLLGAVIVGTRSGGPAWSPVAVATVIVVFALTRWFTTSYRIGADTVQLRRGLLQRRTLTVPRSRIRSVDVHADLMHRLLGLVVLVIGTGQHADREKRFHLDGVDARQVPELRALLLRPAENTQPDPATAAGAFGQSNSVHNGISAGRAALQRALNGGESGALADDAIEIGHWRPRWVRYAPLSLTGLAIVGPVIGLAAKVGVADVLVHSEAVRDLTEHSAVFIALAVTGAVVVLLVIAAIAACIRYLTTYFGLRVLDDGTALHIRSGLFTTRQTTLDLSRLRGATVKEPLLLRLAGGAELEAIMTGTSPRQKLLPQAPRAAVDRTLAQLLTSRSRRGTAASEHAAPQQLWDDPATAAAPASVALEQHGPRARRRRYTRAFIPVWILLAAFAATVLAGRHVPPWAWVLPVMVAFVAAALAHDRYRGLGHAVIPSDGERPVWLITRRGALDRDRDCLEAPGVIGWTVRQTFFQRRAGLATVIAASAAGKKKYSIVDLPIERAWTLIDQVTPGQLGMRAEYETTPVPTPDSVPDGAVAKPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVF8</accession>
    <name>A0A231GVF8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase 1</fullName>
            <ecNumber evidence="2">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qorA_6</name>
        <name evidence="2" type="ORF">B7C42_07344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40535">
        <property type="protein sequence ID" value="OXR40535"/>
        <property type="gene ID" value="B7C42_07344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="30562" checksum="ADDBA860C0E804FD" modified="2017-10-25" version="1">MKKVSFAEFGGPEVLDLVGAEEPHAGPGQIRIAVRAAGVNPVDWRIREGQFQQAHPLELPAGVGQDAAGVVDEIGEGVTGFAIGDAVFGEGSSTYAEFAVLSAWAPMPDGLAFEEAAGYPSVVETALRIIDQVGARPGHTLLVSGASGGVGSAVLQIARERGITVIGTAGAANQDYLRSLGALATTYGEGWVERVRRLGRVDAALDLAGSGVIAELVELTEDPQRVITIADLGAPEFGVRFSGVAGSMPDALGAAADLIARGKLHIPVEKTYTLAEAAAAHVDSQAGHTRGRRVIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVS4</accession>
    <name>A0A231GVS4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40688">
        <property type="protein sequence ID" value="OXR40688"/>
        <property type="gene ID" value="B7C42_07246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="53" mass="5735" checksum="12E8B1C983EAA433" modified="2017-10-25" version="1">MGPNSRISTPHDTAAVHNALMLDVYYGLFLLLFEGERLSHIFGVALDSGNLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVY5</accession>
    <name>A0A231GVY5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="234856">
        <property type="entry name" value="M.Nce30759ORF7162P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40738">
        <property type="protein sequence ID" value="OXR40738"/>
        <property type="gene ID" value="B7C42_07162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="152"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="665" mass="75189" checksum="9C9758E4ADFF244E" modified="2017-10-25" version="1">MNTSKHTELANHAWSVADLLRGDYKQSDYGKVILPFTVLRRLECVLEPTRDKVRETAERFEGQDIDVDSFLRRASGNTFYNVTDLRLKTVLGDPSHLAKNLQAYVGGFSENAREVLDRYEFNQQIKRLDTANLLYKVTGKFADLDLRPEVVSNHNMGYVFEELIRRFAEQSNETAGEHFTPREVIELMVNLLVAPDADLLSVPGVVRTVLDPACGTGGMLSSAEEHIKQMNPQAKVEVYGQELNPESWAICRSDLMIKGQNPDHIVFGNSFSDDGHKNVKADYLLANPPFGVEWKKVKEEVEWEYKNLGDAGRFGAGLPRINDGSLLFLQHMLSKMKPAEVGGTGGSRVAIVFNGSPLFTGAAESGESNIRRWIIENDWLEAVVALPDQLFYNTGISTYFWILTNRKSPQHRGKIVLLDARDYWQKMPKSLGDKRKRLAPEHIEEITRLYGNAVEVADDPEHPLHGKVKVFRNSEFGYRRITVERPLRLRFELTAEALDQLVEASAVRKQYSDPDAFRKLLAPLVGSSWDKKTDAVTALKDLVVGAGEPWPTGAPFAKALRDILGVRDPAGEIQLVKGAPEPDTDLRDFENVPLDEDVDDYLAREVLPHVPDAWVDHIKTKVGYEIPFTRHFYRYKPPRPLEQIDTELKALETEIQQLLREVTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW21</accession>
    <name>A0A231GW21_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40827">
        <property type="protein sequence ID" value="OXR40827"/>
        <property type="gene ID" value="B7C42_07111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="261" mass="28750" checksum="945AEC47F307BE2D" modified="2017-10-25" version="1">MSSRYLPGLSEERRAVIEFCGELTDEQWAAPSAAAGWSVAEVVIHLTTGVRALLTPSAAAIVATRDLERLNEQLVDEKRSHTTRHVLLEFDTWSRRGVRALTVFTAAGIRRIQLPIGELGWYRLDLIPAMLLFDWHTHLRHDIAPALDLPPPPTDALRMNAILTWLTVLLERSHREALSWLDAPVALTFTGPGGGTWRIEPRGGRLRVRPGRAAGAAAHIAALALEFPQWGTRRLPWRAGAVAITGDAELGARVLDSINLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX97</accession>
    <name>A0A231GX97_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_30</name>
        <name evidence="1" type="ORF">B7C42_06635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41237">
        <property type="protein sequence ID" value="OXR41237"/>
        <property type="gene ID" value="B7C42_06635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="26886" checksum="C6CE38ECC35FF9AB" modified="2017-10-25" version="1">MTGTEIATTATTSNVTFDFTGQTVIVTGAARGIGLEIGRFFHTAGAHVYLVDYDADALDAASADIGCHSAVADVSDTPSVQAVVDKVIAETGRVDVLVNNAGILRDRVLWKLTDEDYEQVMAVHAGGTFRFTRACAPHFRAQHHGRVVNVTSYTGLHDNVGQSNYAMAKAGIIGFTKTAAKELAGFGVTVNAISPNAETRMIASIPDDKRAELTAQIPLGRFADPREMATTVAFLASAEAGYITGVVVPVDGGISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXA6</accession>
    <name>A0A231GXA6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin CarAc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">carAc</name>
        <name evidence="5" type="ORF">B7C42_06652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41254">
        <property type="protein sequence ID" value="OXR41254"/>
        <property type="gene ID" value="B7C42_06652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="108" mass="11966" checksum="7D7FD9B0AC376DD7" modified="2017-10-25" version="1">MEGTRTTERRFVCTVDRLDRGESMTVAGDVPIALFRNDDGDFYATADTCTHEDWSLGEDSDLEGNEVVCPLHMARFDIRDGRPLCFPATVALATFEVEVADGNVYIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXN9</accession>
    <name>A0A231GXN9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043052.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41387">
        <property type="protein sequence ID" value="OXR41387"/>
        <property type="gene ID" value="B7C42_06530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="25826" checksum="25406219F3908451" modified="2017-10-25" version="1">MFDSGVEKAVRSLLDNGAQVQAPAVAKYVDRFRRAHPDESPAQILDRLEKIYLTTVTGSGTAVGATAAVPGVGTLTSLAAMSAETTFFIEASAVFTLAVAAVHGIAPEDKERRRALVLAVVLGESGMEIVQQSVGHSAKNWGTLLAERIPGIKGMNESLMKRFVVQFITKRSMLMFGKVLPAGIGAAIGGFGNRALGKNVIANAHKAFGPAPMRWSGGTARGTVIDADPLPALGNPDGTASGSTAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXU5</accession>
    <name>A0A231GXU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase FadD13</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780413.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41392">
        <property type="protein sequence ID" value="OXR41392"/>
        <property type="gene ID" value="B7C42_06535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="418" mass="43622" checksum="2285506230F0AB7F" modified="2017-10-25" version="1">MTQLLIEYPQTRNPWCGNPLARGADGVLRYGNLNPALTELLDVQVHAFSAREAVVEIGGPRLTYRQLWHAASRIAGGLQEHGIGYGDRVAVRMPVGARWVQAFLGALLSGAVPVLVHDGLPDAVAAQVIADSCADFVLDGGGAEAGYADFPDGAAFIDDGASLSELALLCYTSGAAGQGFSEAPGGPRGVELTNENLLSAVRSVVGAFDLPTEGLRNLVLSPLAHASGCVDQLLPTFAVGGTVVLAPDPAMIAETIVAERIDMVAATPRIFAGLLPELAGLRAEGVRQVCSAGHRAELAATDAGTAEIVAEALREVFPLARQWSVWGATETSGIGLALVDSGTTPGRDVLGFPFGGTELALWGPRAEVGSGELLCRGPNITPRYWNDPQTTESRFTGSWFHTGNQVSIDTDGLVHRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY42</accession>
    <name>A0A231GY42_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ECF RNA polymerase sigma factor SigG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigG_6</name>
        <name evidence="9" type="ORF">B7C42_06429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41537">
        <property type="protein sequence ID" value="OXR41537"/>
        <property type="gene ID" value="B7C42_06429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="345" mass="37271" checksum="4183EC94541330B1" modified="2017-10-25" version="1">MSVSASEPLPESGRPESGVAGSGVSGPGALEALRIPLTGYCYRMLGSSADADDAAQETLVRAYTRFDRFDPERGRLSTWVHAIATNICLDMLRSARRRMLVWEGPVSTGFDPDAVVPADRWLDPVADARVLDPAERVVRRESVRLAFVAALQHLPPRQRAVLVLREVLAFSAAETATMLEVSPAAVNSALQRARTTLAAVRPAATDPLDPGDPDDRDLVRRYVTAFENHDVDGLAALLCEDAESGMPPFAWRLSGRELIVSVFAAGDACAHDRLVPVRMNGSVGFGQYRPDTDGVLRPFALLAVEARSGLIARQVTYLGSGDRFAEFGLPPIFRARTDEFSPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYC5</accession>
    <name>A0A231GYC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular esterase EstB</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">estB_9</name>
        <name evidence="1" type="ORF">B7C42_06226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41585">
        <property type="protein sequence ID" value="OXR41585"/>
        <property type="gene ID" value="B7C42_06226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="24865" checksum="B79C72AA163ABE8F" modified="2017-10-25" version="1">MLIHGLSNDTISWNTLSPVLAHTGYCVYTITYGTESLGPIGATVPVQDSATQIGDFVDEVEAATGAKHVDLVSHSIGGAVAYYYLSRLGGASKVGRYIALAAPLHGSTLSGLAGLQPLVESTGSGAAATRRCGPCQLSPGTPFLQDLEPNPGATPQIPFTMIVTRYDQIATPYTTGLLDGPNVHNVVLQDLCPTDFTEHNELTSDPVAIHEVLDALDPAHATPPTCTMVLPLLGPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYE5</accession>
    <name>A0A231GYE5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778300.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41653">
        <property type="protein sequence ID" value="OXR41653"/>
        <property type="gene ID" value="B7C42_06294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="116" mass="11984" checksum="054C3243503ADD75" modified="2017-10-25" version="1">MTVVYNLVVIAHLLGLAAVIGGYAAGRPAVSQVMLWGARAQIVTGLILVGMADSIDSLDKNLDMAKIVVKLVIAVAVAGLAEIAHADAKRGKTIAWMADAAGLLAIANVFVAVLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ06</accession>
    <name>A0A231GZ06_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Redox-sensitive transcriptional activator SoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">soxR_3</name>
        <name evidence="5" type="ORF">B7C42_06188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41846">
        <property type="protein sequence ID" value="OXR41846"/>
        <property type="gene ID" value="B7C42_06188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="151" mass="16877" checksum="5B1D93C0C3AC4D0B" modified="2017-10-25" version="1">MTPPHPEVAEVTIGELAERSGVPASALRFYERQGLIHSRRTIGNQRRYTRATLRQVAFIRASHHLGIPLSVIGKVLALLPPGEVPGQEFWARASDCWAEDINSRIARLERMRDRFSECIGCGCLSFQQCALVNPNDELGKEGPGPRRLFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZH6</accession>
    <name>A0A231GZH6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic hydroperoxide resistance protein OhrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ohrB_2</name>
        <name evidence="2" type="ORF">B7C42_05997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42013">
        <property type="protein sequence ID" value="OXR42013"/>
        <property type="gene ID" value="B7C42_05997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="14696" checksum="1E0FA0367A53C212" modified="2017-10-25" version="1">MADITYTAVATSTAEGRNGGRATSDDGALDITLAVPKALGGAGGGSNPEQLFAAGWASCFVGAVRRVAAAKKVTPKDLAVVAEVTLHHHTERDEFRLSAALHLEASGIDQQTADELVAGAHLVCPYSKATRGNIEIELDATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZM2</accession>
    <name>A0A231GZM2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42058">
        <property type="protein sequence ID" value="OXR42058"/>
        <property type="gene ID" value="B7C42_06042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="354" mass="37468" checksum="929029AFA859A247" modified="2017-10-25" version="1">MVLAPEIDTPTMIEHAAERVARVPRSGPGVEPVLVAVLYLPGPARSVADGERALSPTAAGAVLAGGDPRRQARAVDSSHGYFAVDGRGFTPNRMAASQWSADQVVGPALCGLLARALDNEHATDGFVPVRLTVDLFKPARMHELSVSTTRVRNGKRIRLADAVVTQDGEPAARASVVFLQPSEQPPGEIWTRDRQPVPPSLEVAPPSDLPTAPLWHSDDSAHWSRVPSEHENGSRKRSWQHPVNVVDGERPSPFVVAAMAAEQTSMVTNWSSAGVGFINTDLTLALVRMPEGADIGLEADNHLSRDGIAAGTATLFDRHGAFGSAMITAVSNAARQITASHLDGVIASASGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZS4</accession>
    <name>A0A231GZS4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42108">
        <property type="protein sequence ID" value="OXR42108"/>
        <property type="gene ID" value="B7C42_05707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="6980" checksum="A08B3A771D6B981A" modified="2017-10-25" version="1">MKITVDYARCEGHGLCAEQAPEVFSLDDDAELIYHFDGVNVPEDKVTAARAAIVSCPVAALREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZX1</accession>
    <name>A0A231GZX1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator YttP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yttP</name>
        <name evidence="5" type="ORF">B7C42_06035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42051">
        <property type="protein sequence ID" value="OXR42051"/>
        <property type="gene ID" value="B7C42_06035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="20938" checksum="DA3B315AB7ECB74D" modified="2017-10-25" version="1">MAGRRTDTRDRIRSVAMELFSAQGYEHTSIREIAERLAITKAAVYYHFRSKEDIVVSLADDLRTGIDDLLAWAENQPPGPETGREILRRYGAVLHHTGREMTRFMYENQPAFRRLGVGSVLRYQFRAVADAMTAPGHDPLAVFHARQALLAISWSIGMMGDVDLTDEQCRRAAEDIALAIYERAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZY1</accession>
    <name>A0A231GZY1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome P450 136</fullName>
            <ecNumber evidence="2">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42160">
        <property type="protein sequence ID" value="OXR42160"/>
        <property type="gene ID" value="B7C42_05759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="447" mass="50829" checksum="AFE8F11B696711AE" modified="2017-10-25" version="1">MTADALETRPLPTQRREDRGYPVLGQLLQYAQDPLALFQREWDHYGPVAPMYSLGRTAALLLGPDACGEALLNKDGALANEPAWSRLVGPFFHGGLMLIDFDEHKRHRRIMQQAFTRPRLQAYTERLHPAIEQGVEHWGESESFPAYWKLKQLTLDIAADLFMGGAADTTPAEMDRINRAFIACVQAAAGIVRGNVPFTRWGKAYRGRKILEDFLRHYLPAKRAEQTDDIFSVLCHIEDEDGARFSDDDVVNRMIFLMMAAHDTSTITTSTILQYLGQHPEWQQRCRSEAAALGPAPSMAELERLESVDLVMREALRLRAPVPVLVRYAVKDTVIHGVRIPAGTDVVIGIQFTHLMPQYWTDPHTFDPDRFGPERREDKSHRFAWEPFGGGAHKCIGMHFGGLEVKSIMHRLLRDYHWRVDPAYVPPLDYHSLPYPKDGLPITFVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H015</accession>
    <name>A0A231H015_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator KdgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdgR_4</name>
        <name evidence="5" type="ORF">B7C42_05797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42198">
        <property type="protein sequence ID" value="OXR42198"/>
        <property type="gene ID" value="B7C42_05797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="78"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="28226" checksum="6031C3574C7316C8" modified="2017-10-25" version="1">MSTAESASNGARPVDGSTVLGKVMAVLESFSIDDGGLSLAEIGRRTGLPKGTLHRVLSDMVTVRLLERTEVGYRLGGHLFELGMRASVERSLLEVAIPFLEELNARIHETVHLGVLDGTDVVYLTKIGGRRQASAPSRIGGRMPVHCTAIGKTLLAHADRSLRDRVLTGPLPAHTPRTIVLPGTLRRQLDRIAAEGVAYEFEESAPGLVCVAAPVREADSVVAAISIAGASHRFHPESHVASVRAAADGIGATLTRRARMMSAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0J0</accession>
    <name>A0A231H0J0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42338">
        <property type="protein sequence ID" value="OXR42338"/>
        <property type="gene ID" value="B7C42_05537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011296663" evidence="1">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="15394" checksum="61FDA3BAA64A6D83" modified="2017-10-25" version="1">MPKTARAAAAAAATVGAVTAIASASASAQTVEFPQTPSVFYGGLCGGNIRTWVDTSPDWPGRAVFNVQALAIQGVGPGQFPLAPLCNVDTTVAWRNTNTGAAGEYRLNVVSGIYGSILYAEFQNTGPGHIEVTVTTNNLNIPAHGAFDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0M9</accession>
    <name>A0A231H0M9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate--cysteine ligase EgtA</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthase</fullName>
            <shortName evidence="2">GCS</shortName>
            <shortName evidence="2">Gamma-ECS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">egtA</name>
        <name evidence="4" type="ORF">B7C42_05604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2 3">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42403">
        <property type="protein sequence ID" value="OXR42403"/>
        <property type="gene ID" value="B7C42_05604"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02034">
        <property type="entry name" value="EgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017809">
        <property type="entry name" value="EgtA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035434">
        <property type="entry name" value="GCL_bact_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011556">
        <property type="entry name" value="Glut_cys_lig_pln_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378">
        <property type="entry name" value="PTHR34378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378:SF1">
        <property type="entry name" value="PTHR34378:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017901">
        <property type="entry name" value="GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03444">
        <property type="entry name" value="EgtA_Cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="428" mass="45539" checksum="381E7E9043A86292" modified="2017-10-25" version="1">MAVTVDKAPAGLSAGLSSRAAAEAYVGGVCFKQGPPTLIGAELEWLTARGELSAPDSRPRLSMLADALGPYAPQSVSPDSPAKVLPGGSRITLEPGGQIELSSAPFADAAQLCARLLEDSRFLSDLLETRSIRTYSAAADAGRQARRVLRLPRYRAMERAFAGVGPYGKLMMCNTAATQVSVDAGADPAEIAARWNALYAVGPALVAAFACSPHLHGAPAGAWASQRMRTWLRLDHVRTRPPVRSWADPLTDYGRWALDTPLLCVRRGPAETDWSAPPGATFADWLCGALDDEIGRRPEVEDLDYHLTTVFPPVRASGHLEVRYLDAQPGDQWSVPIHVVDALMSTPAVVAEATALAEPVADDWASAARCGLADPQIRSVAVELLTLAAEHARSDDAAEQIWAAVRRCRSGRMPDGEAAHCAPAETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Y3</accession>
    <name>A0A231H0Y3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enoyl-CoA hydratase echA14</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42467">
        <property type="protein sequence ID" value="OXR42467"/>
        <property type="gene ID" value="B7C42_05243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="25274" checksum="9AA2EFDE0F963C5C" modified="2017-10-25" version="1">MERRDTVAVVTVSDPQRRNALTLGLSEQLAAAIAEAEADAGVHAVVITGAPPAFCAGADLSALGEAAEEGLRAIYAGFLAVAECSLPTVAAVGGAAVGAGLNLALAADVRLAGPRARFDARFLRLGIHPGGGMTWMLQRAVGAQRAAAMTLLGEILDADAAHSAGLVHRVVLGDHDDLVSAAVELAAGAAEAPRELLITTKATMRHTRTLDSHAEAVDAEIVPQVASLDSAEFAARLAAMKARISAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H150</accession>
    <name>A0A231H150_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTP pyrophosphohydrolase</fullName>
            <ecNumber evidence="3">3.6.1.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nudG</name>
        <name evidence="3" type="ORF">B7C42_05297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.65" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42521">
        <property type="protein sequence ID" value="OXR42521"/>
        <property type="gene ID" value="B7C42_05297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="139" mass="15397" checksum="248057E79508DA12" modified="2017-10-25" version="1">MRIESSRRLIDTVAWVLIEDGRILCARPDGKDEFYIPGGKREGEETDRQTLTREISEELTVVLIPESIAHVGTYEAELPGATEVSVRMSCYTADYAGTIEPSSEIAEIAWFSYADRAAVPPVDQVLFDDLVARGLLPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1B7</accession>
    <name>A0A231H1B7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42601">
        <property type="protein sequence ID" value="OXR42601"/>
        <property type="gene ID" value="B7C42_05378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="17615" checksum="45F2BCC3644924BF" modified="2017-10-25" version="1">MDSADRLAITALTAEYARAVDRRDSAALTALFAPDAVLVLPPVLNGTERAVELAGTQRVVSSVTDAVSGFVLTRHVVEQCVLEPVSRDRVRGEVYCTAHHVSRRPDGYRDRRVAIRYQDTFDRIGEHWLFSRRELVVDFIEDVAVRVPEAPGAEDAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1V5</accession>
    <name>A0A231H1V5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sensor histidine kinase pdtaS</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdtaS</name>
        <name evidence="2" type="ORF">B7C42_05145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780226.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42807">
        <property type="protein sequence ID" value="OXR42807"/>
        <property type="gene ID" value="B7C42_05145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011102">
        <property type="entry name" value="Sig_transdc_His_kinase_HWE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00911">
        <property type="entry name" value="HWE_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="305"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="504" mass="54345" checksum="05BD48AF8527583E" modified="2017-10-25" version="1">MSTLSDLLAEHTDLPGAAVDHLQRVVGDWQLLADLSFADLQLWVGIGPVTDGADVVCVAQCRPTTAPTVQPDDLVGSLASRQEHPQIFQALSSGEIVRVEGDGESTGVYHPTPARVIREGIPVRCGTDVIAVLGRDTDMQRSKVRGSLEHAYMSCADDLCQMIADGTFPTLEDRTGSHSSPRAGDGFIRLDTAGLVVYASPNALSAYHRMGLQSELAGHDLAQSTRSLITDPFDAQEVVSDIQAALAGKSGRRMEVEARGATVLLRTLVLRPHGELAGAAVLVRDVTEVKRRDRALLSKDATIREIHHRVKNNLQTVAALLRLQARRTENEEARVALTESVRRVTSIASVHEMLSMSVDEEVDLDEVVDRLLPIMADVATVHTARIKVRRDGSLGVFSAERATPLVMVLTELVQNAIEHAFDAGENGTVTIRSERSARWLDVIISDDGRGLPEGFSLDGSDRLGLQIVRTLVTAELGGSIGLHPGADIGTDAVLRVPLGRRNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1V7</accession>
    <name>A0A231H1V7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42834">
        <property type="protein sequence ID" value="OXR42834"/>
        <property type="gene ID" value="B7C42_05172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="276" mass="31325" checksum="B17A8D9B43D892B2" modified="2017-10-25" version="1">MTGTVEVTQELGAFLRTRRERLDPGDFGLPLRRRSRRTPGLRREEVADLAGVSTDYIVRLEQGRGVRPSPEVLDALAQALRLAPDERIYLFDLARQRPPDDGKPATTASPELARLVADLAPIPAMVLNHRYDILAWNREMSRLLLDFDTLPPRQRNSMWLCLLYPGMGNFYADRERTVREGIAGLRAAWAAHPDDRVLAELIDEFRTGSAEFAELWKRRDVRVQGRGRKTMHHPRVGAVTVAYEALMPLQDPDQRLIIYRPADEASRAALDRLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1X8</accession>
    <name>A0A231H1X8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036504404.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42846">
        <property type="protein sequence ID" value="OXR42846"/>
        <property type="gene ID" value="B7C42_05184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="138" mass="15488" checksum="69B1090465014345" modified="2017-10-25" version="1">MKYMLIMRATDEAYASMGEVDFGTMLETMGKFNDELIRAGVLLAAEGLDPAESVVVDYDGETPVVTDGPYGETKELFGGFYLLNVASKEEAVEWAKRMPVIVKGCKTEIRRVPTIDEFPQDNVWIQKERAWREATGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H234</accession>
    <name>A0A231H234_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein B7C42_05225</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_05225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42887">
        <property type="protein sequence ID" value="OXR42887"/>
        <property type="gene ID" value="B7C42_05225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="912"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="930"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109750" checksum="077BD5B438FDD3BD" modified="2017-10-25" version="1">MGMRPPTGLPSLSRRSRILLITALVIAALLLVGPRLTDAYTNWLWFGEVGFRQVFTTVLVTRLLLFLIVAVVVGALVWLALLAAYRTRPVFVPVSGPSDPIARYRTTVMGRLRLFGIGIPVLVGLLSGLVAQSSWVTVQLFLHGGSFGIKDPQFNIDVGFYAFDLPFYKLLLNWLFVAVVIAFFANLVTHYIFGGLRLSGREGTLTRPARIQLALIAGTFVVLKAVAYWFDRYSLLSSTRKEPTFTGGSYTDINAVLPAKLILMSIAIICAVAFFAGVVLRDLRVPAMAAALLLLSSILVGAVWPLVVEQFEVRPNAATKEATYIERNITATRQAYGLTDDKVSYVDYKGSQTKDPGSIPADQQTIGNIRLLDPNLLTQTFIQRQQLQNFYGFPDPLDIDRYTINGEKQDYIVAARELVPQNLSGNQTDWINKHTVYTHGDGFVASPANRVNVAPPKETQQAATGAGTSSSSGGYGYPVFNVGDKSTVSDLFTPKDKQAIPVDQPRIYYGEMISKSDADYAIVGGNNQPPREYDTGTDQYTYTGKGGVPIGNWFNRLAFAAKYAERNILFSGAIGSDSKIIYNRDPRSRVQQVAPWLTTDGDMYPAVVNGRILWIVDAYTTLDNFPYAQRTSLEGVVEDSIDQNTGRTLPRKEVSYIRNSVKATVDAYDGTVNLYDVDPTDPVLNAWRGVFPNSVKPQSEISPELRAHFRYPEDLFKVQREMLARYHVNDPREFFTNNAFWSVPNDPTSDTPTNAHQPPYYVLIGDPKTGRPQFNLTSAMVGFKRQFLAAYIQVASDPENYGKFTVLKLPTDSQTPGPQQVQTSMTTDARVSNDRTLLTGGNTNKIKYGNLLTLPIGEGGILYVEPWYLERNSGPTTASFPQLVKVLASYGDKVGYQSTLGDALNDVQDGLGAATTQQPGQAAINPPGQQGSTSPPPSNQNTPPPSTTAPPPTTGSAGKDAAVKELNDALKGVEDAQKSGDLGQLGKALQGLQKAIDDYNKAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2C4</accession>
    <name>A0A231H2C4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42993">
        <property type="protein sequence ID" value="OXR42993"/>
        <property type="gene ID" value="B7C42_04879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="29228" checksum="ADD23CB34BCB0917" modified="2017-10-25" version="1">MTSDRTIGELLREWRHRSRLSQLDLAIQAEVSPRHISFVETGRTIPSSAMVLHLAEQLGVPLRERNRLLVAAGHAPVFRAHPLHDPDLARVRETVQQVLLGHEPYPALAVDRRWNLLAANSAVDVFLQGADPALLTPPINMMRVGLHPDGLAPRLRNLEQVRGYLLPRLAHQAARTGDPHLHALYEELAEFGPAHEPSPPDPTDIALPIRIAHRGTELCLVNTVTTFGAAFDITLDEIAIEAYFPADLATRRFFRTNGTSGDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2R5</accession>
    <name>A0A231H2R5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_15</name>
        <name evidence="3" type="ORF">B7C42_04575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43153">
        <property type="protein sequence ID" value="OXR43153"/>
        <property type="gene ID" value="B7C42_04575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="443"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="531" mass="58193" checksum="13D977BAD8BBF4D6" modified="2017-10-25" version="1">MSATELHANLIHRVNVGDSLTRSADRRPNAIAVVEGDARYTYAALNTWVNRVANALHDRGYRRGDSLALASGNCVEFLVTYYACAKLGVVCVPINLGWRSQETAYVLEHSSSRGIVVESQLLEQISDALLQVPAVAEVIVAPGIGAGEWNTVPGRSRLTFAELTSAGSVAEPEHLVGDRDPITYLYTSGTTSFPKGVVGNHTAIYLESMSMALESGFRDDDRFIAMLPMFHTAQLNCHCTAALMVGATIYIRRGFDADGVLDQIEREAVTQIFGLPTMYRAMLEHPQLKERDLSSLRRACYAMAPMPNAQLEQCLTAFGCDFYLLFGQTEMSPTATMFRPEHQLSHAGAVGTPVVNIQVAIMDAEGDRLPRGAEGEIVYRGPHTMTEYLNNRAATEEAFAHGWFHSGDIGHIDGDGILWFSDRRKDVIKTGGENVASIEVEKAVYAADPNVAEAVVVGLPHDRWSEAITAVVVAKQGARIDETELKAALRHHVDAYKVPKAVIVVDALPRTSTGKIQKNIVRQQFSDYYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Z9</accession>
    <name>A0A231H2Z9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-(Acetamidomethylene)succinate hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.29" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43243">
        <property type="protein sequence ID" value="OXR43243"/>
        <property type="gene ID" value="B7C42_04665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047411">
        <property type="term" value="F:2-(acetamidomethylene)succinate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="59"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="324" mass="34842" checksum="18C29369E2D101D3" modified="2017-10-25" version="1">MVGEPVTGCVRPNGAVGSQPSSVVRKGAVSVRHLEHSLPGAGVRLAADRWAGDHADGRGVVVLLHGGGQTRHSWRRTGIRLAEAGWVSYAIDLRGHGDSDWHPGGDYSVAALVDDLRELLAPIRRANPGLPVALVGASMGGKISLIAAGEDASLAQALVLVDIAVRVEVRGGRRVREFMQSAPDGFASLEEASARIAAYNPHRPRPSSVEGLRKNLRLREGRWYWHWDPAMMRSADGDDDRPVSPQVYERAKAAAQRITCPVLLVRGQLSDVVSDEGVAELRELIPHSEVIDVREVGHMVAGDDNDVFTANLLGYLNSSLPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H370</accession>
    <name>A0A231H370_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase</fullName>
            <ecNumber evidence="2">1.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43246">
        <property type="protein sequence ID" value="OXR43246"/>
        <property type="gene ID" value="B7C42_04668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="32989" checksum="0F7D367AA5AF27F3" modified="2017-10-25" version="1">MSLKFNLMFPMRAVKHYPRWIGESDFGAVAKFVEDAGFDGLSVSEHPYPDKKWLANGGHHAFDPFVALSIAAQATTRLRLITYVMVAGYRSPYLGAKSAASLDLLSGGRLTLGLAAGYLKSEFEALGADFAHRGALLDEAIAAMRATWSGVDHEGPQFGAAGHISLPPPQQQGGPPIWIGGNSAAARRRAVELGDGWLPMGQSAEMAAITRTPPLEDIGTLRTMIGEQNARRAELGKSVLDVSFVPFEANLLHSGDSTAFCDAVQPLLPEYADAGVTWITIEPASRGIDDFRADISMIADRLIKPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3K0</accession>
    <name>A0A231H3K0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43427">
        <property type="protein sequence ID" value="OXR43427"/>
        <property type="gene ID" value="B7C42_04294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025492">
        <property type="entry name" value="DUF4383"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14325">
        <property type="entry name" value="DUF4383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="174" mass="18161" checksum="71A8F3D5717392B1" modified="2017-10-25" version="1">MATASVSRHRARVSPVQAAAYVVGAAFLVVGVLGFIPGVTTNYDMLTWTGHHSGAELFGVFQVSALHNIVHLVFGVAGLAMGRTTMTARTYLIAGGVVYLALWVYGLVVDKESTANVIPVNTADNWLHLGLGAAMLLLGLFLGPAGDRPILFEGSPQPGRPESAPPGTGHGRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4E9</accession>
    <name>A0A231H4E9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPK2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43731">
        <property type="protein sequence ID" value="OXR43731"/>
        <property type="gene ID" value="B7C42_03966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="65"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="32229" checksum="6F806FDF848EA689" modified="2017-10-25" version="1">MAKSPWTEPATTALRAAGVRLDSYDPSGTPGFTGDKKLGEQLLPERGEVLSDLQEMLFANGRSGDHRNLLLILQGMDTAGKGGVVRHVIGMVDPQGVRHAAFGVPTDEERRHHYLWRIRHRLPAGGQIGVFDRSHYEDVLVVRVQNLVSREVWEPRYDEINDFERELTAAGTTIVKVAMFVSLDEQKRRLGERLERSDKYWKYDPSDIDDRALWPEYQRAYQDVLDRTDTEHAPWYVVPADRKWFARLAITELLIDALSGLKLTWPAPHFDIETEKARLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4F1</accession>
    <name>A0A231H4F1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">proC</name>
        <name evidence="6" type="ORF">B7C42_04014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781190.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43779">
        <property type="protein sequence ID" value="OXR43779"/>
        <property type="gene ID" value="B7C42_04014"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="163"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="27830" checksum="E769F6355648B0B9" modified="2017-10-25" version="1">MTRIAVIGGGRIGEALIAGLLEAGRPGKDLVVVETVTARAQVLSERFGIRVTDSLAEAAAGADVLVVAVKPHDVDAVLTELGKLELDNDRDQILVSLAAGVTTARVESKLPAGFPVVRVMPNTPMLVGQGMSAIAAGRHAKSGELDTVSELLGAVGRVVTVAESQMDAVTAVSGSGPAYFFLVVEAMVEAGVGLGLTRDVATELVVQTMLGSAALLEESGQDAAELRAAVTSPAGTTAAAVRELERGGVRSAFWEALHAAKRRSVEQGATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4U5</accession>
    <name>A0A231H4U5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43875">
        <property type="protein sequence ID" value="OXR43875"/>
        <property type="gene ID" value="B7C42_04114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="27635" checksum="C07CF1C0F2E8DFB4" modified="2017-10-25" version="1">MSSDLPNPSSQPAVEPPDAAEKAVADASPEETARPGAPVGDATGESVRPSAGEQPSAARPGSSTLRTVVTSVAAVWLVAALVLAAWFGAGWVRAVWFTDGPRADARDTALDAARQAAINLTSMNPGDVEGSITTMRSSMTGDMLTQLNENHDRIKDAAEKSKTKIDSKVLGAALSSLDSERDKASAIVVLKLTQTAPNVPVQSFRATWTLDMKKDGDTWKAEQANSLGQLVSLDTPGPAGAAPPPANGNAAPAPSAPANPSEAPAPQPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4V5</accession>
    <name>A0A231H4V5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517105.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43901">
        <property type="protein sequence ID" value="OXR43901"/>
        <property type="gene ID" value="B7C42_04140"/>
    </dbReference>
    <dbReference type="GeneID" id="66723045"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="7184" checksum="2E01C045A6E69E35" modified="2017-10-25" version="1">MAKEIDRVRARSALETVKESPFIALVAAVPVIVVLGVVWALTNWFVALLVLVLLGAVVVVRGKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Q8</accession>
    <name>A0A231H5Q8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44219">
        <property type="protein sequence ID" value="OXR44219"/>
        <property type="gene ID" value="B7C42_03779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019051">
        <property type="entry name" value="Trp_biosyn_TM_oprn/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011746">
        <property type="entry name" value="Trp_synth-assoc_CHP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09534">
        <property type="entry name" value="Trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02234">
        <property type="entry name" value="trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="341" mass="34959" checksum="DA98456EDBFEC404" modified="2017-10-25" version="1">MSNPESDPAQRHSPDRPEGTAAPGTNGTSPTAASPRRSDAGSSAADRAPVPPSADRDPIRSGPGDEDAGADAAAAVRRDDPSAPRTGDGDPDRYVPETDTGEAENPPAKRARPVLPVLLLAIGAAALWGSSRMTWVTVRSSDGLTEPRTQHLDGGLWFGALTPLALVLLASIAAVFATKGWLRRLIGVVVALVAAVAAVPGLALLTQHGKLAERAARLAELPARAHVDAATAATFPAALSVVGALAAFAAGVLLARMPETTARMSGKYDNPVFRRAAAAEQVAELRRTGETSSAAKAADAPRPATPASPPHPEPESGELSQRVLWDALDAGADPTDDEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5T4</accession>
    <name>A0A231H5T4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2235 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44167">
        <property type="protein sequence ID" value="OXR44167"/>
        <property type="gene ID" value="B7C42_03726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="DUF2235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="DUF2235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2235" evidence="2">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="441" mass="48274" checksum="A45078E3F0063F8B" modified="2017-10-25" version="1">MKRLVVCCDGTWGSESNPTVSNVVKIAESVRSSAVSDAGDHVGQRVFYVDGPGSRGYLADKLLGGAFGLGLDANLSTMYWQLALNWEPGDEIYVFGFSRGAYTARSLVGMVNRLGLLTADAMIERAYPEALAIYRQRKVDPDGPDRPEWIEFRERHCVYPVPIHFVGVFDTVGALGVPLLTSWRYRFHDVRLSRNVRYARQALAIDERRRMYAPCLWEVTDDPDGGPTGADRVQQVWFEGVHTDIGGGYADSRLSDITLRWMVDQARRAGLSFDDERIEQLLNGRTPVQPAAAPDSTVAVPDSAVAVPDSAVAVPDSAVAVEDSTTKSPPRAHDSLTLFYRVLNRVGWALHPRNPRFYADSWRRLSAPGDRLVYLADCAAPCATYRPPNVVRWAEELAGPLPTLPVGEHDEGADRRHPAAEQHVPGGEHPAGSGSVAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H624</accession>
    <name>A0A231H624_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argH</name>
        <name evidence="8" type="ORF">B7C42_03872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777672.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44311">
        <property type="protein sequence ID" value="OXR44311"/>
        <property type="gene ID" value="B7C42_03872"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="20"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="371"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="471" mass="49811" checksum="DBE8BC951F471E8C" modified="2017-10-25" version="1">MSQATNEGALWGGRFASGPAAAMAALSKSTHFDWALAPYDIRASKAHARVLHKAGLLSEADLAGMLDGLDRLAADVASGAFTPAESDEDVHGALERGLIDRVGAELGGRLRAGRSRNDQVATLFRMWLRDAVRRIAFGVLEVVDALVEQAAAHPDAVMPGKTHLQAAQPVLLAHQLLAHAHPLLRDVDRLRDFDKRAAISPYGSGALAGSSLGLDPEAIAADLDFDAAAANSIDATSARDFAAEAAFVLAMIAVDLSRMAEEIIIWSTPEFGYITLADAWSTGSSIMPQKKNPDVSELTRGKAGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPLFDSVAQLELLLPAIAGLVSTLTFHTERMAELAPAGYTLATDIAEWLVRQGVPFRVAHEAAGACVRAAEARGVGLDELTDAEFAAVDPALTPQVREVLTVQGSIASRNSRGGTAGVRVAEQLGEVRTTAAEARTWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H636</accession>
    <name>A0A231H636_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor KstR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kstR2_5</name>
        <name evidence="5" type="ORF">B7C42_03828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44267">
        <property type="protein sequence ID" value="OXR44267"/>
        <property type="gene ID" value="B7C42_03828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="21718" checksum="5456FBB97C3A4E98" modified="2017-10-25" version="1">MSPRRAAALHDRDDHDLRAHLIATAEKLFAERGAAGLTVRAIARAAGVSDGVLYNHFDDKEELLAAALRAHVESVDRSFPPLPVAGSGELAENLAVCLRQGLALHQAVLPVFAGLVTQPAVLARFAETEGRQRMWREQLVEYLRAERELGRVAADADVDAAAAVLIGICHDAVLSSLLSGTPRPFVPPPVEAVVATLMSGIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H643</accession>
    <name>A0A231H643_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">argF</name>
        <name evidence="10" type="ORF">B7C42_03861</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44300">
        <property type="protein sequence ID" value="OXR44300"/>
        <property type="gene ID" value="B7C42_03861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="150"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="314" mass="34051" checksum="AFAC6B0B47302B07" modified="2017-10-25" version="1">MTMVRHFLRDDDVTPAEQAEILALAVELKAAPISRRPLEGPRGVGVIFEKNSTRTRFSFEMGIAQLGGHAVVVDGRDTQLGREETLADTGRVLSRYVDAVVWRTFEQHRLDEMASAATVPVVNALSNEFHPCQVLADLLTLREYKGELAGRKLTYFGDGANNMAHSLLLGGATAGLDVTIAAPEGFQPYDWVLEAARKRAAETGATITLTDDPVAAATGADALVTDTWTSMGQENDGLDRVGPFRPFQLNAELLAHAASDVVVLHCLPAHRGEEITDEVLDGPHSVVWDEAENRLHAQKALLVWLLERRSGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H681</accession>
    <name>A0A231H681_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_03149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44361">
        <property type="protein sequence ID" value="OXR44361"/>
        <property type="gene ID" value="B7C42_03149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="51"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="19161" checksum="56B8A7E74CA75E01" modified="2017-10-25" version="1">MALLCSGAALLALPGRITPVARLRAAGGASPVPRRDLRPAAGDPLAVASALDLLASCLRAGLPAATAARAVAPIAPEPFASALRRAADLLALGADPVIAWERAAREAPGAEMSALARLVRRSARSGAALTGAVSELAEKCRAAVEDAAAARAERAGVLISGPLGLCFLPAFVCLGIVPVVAGLAGRVLGGGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6E6</accession>
    <name>A0A231H6E6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775641.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44362">
        <property type="protein sequence ID" value="OXR44362"/>
        <property type="gene ID" value="B7C42_03150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="7343" checksum="C49DEFB84158C378" modified="2017-10-25" version="1">MLTATQSVVRELRSRLIQLAVTDDGMSTAEYAIGTIAAAAFGAVLYTVVTGDSIVNALTKIIDRALNTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6M2</accession>
    <name>A0A231H6M2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cold shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspA_2</name>
        <name evidence="4" type="ORF">B7C42_03154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011206895.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44366">
        <property type="protein sequence ID" value="OXR44366"/>
        <property type="gene ID" value="B7C42_03154"/>
    </dbReference>
    <dbReference type="GeneID" id="66718505"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7338" checksum="F961B7CC51D05CE6" modified="2017-10-25" version="1">MAQGTVKWFNAEKGFGFIAPEDGSADVFVHYSEIQGSGFRTLEENQKVEFEVGQGTKGPQATGVRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6T4</accession>
    <name>A0A231H6T4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44558">
        <property type="protein sequence ID" value="OXR44558"/>
        <property type="gene ID" value="B7C42_03348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895516" evidence="2">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="162" mass="16519" checksum="8BA56324F3FD6D87" modified="2017-10-25" version="1">MTPATRRILATTAFAALSVSIAGATASVASADTPSAAPTTSSAPSAPKLSTGSAFGADKHNDGDGDDQPAAPSVDAIQKVLTKIQNTDKPEDLEKSLDKDVDTLTHNEAAVPAEVKKEFAKFRQELQQAKAKNSLDGSSAADTLKTIKGDAKTLGADLKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6V7</accession>
    <name>A0A231H6V7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44654">
        <property type="protein sequence ID" value="OXR44654"/>
        <property type="gene ID" value="B7C42_03448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="4">
        <location>
            <begin position="508"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="793" mass="84872" checksum="2835A5450CD38BE8" modified="2017-10-25" version="1">MFARRSLDWMTTTDARASDDGAGTHSGADAGPAELGTLTDWLSSRGDDDLVRLLGLRPDLAVPLPGSMTVLAARAEQRASVLRAADDLNTLEFAVIETLATHNAFGGGRQERPLPRARLHELLADRVSPAAVDTALARLIERALVWGTDDLFVVAAAPETLPWQMGATTELPDALTEPEIETALREIGGAERALLDKLATTGPRGRTRDAAPGTDPERPIQRLLARRLLIWIDDETVELPPAVGQVLRREPVTDPHVLTPPHPQTREHSAADVNAAAAGEVGELLRHAGDILEVLSQVPAPVLRAGGLGVRELRRIAKQTGLDEVRVGLLVEVLAAARLLDKGIPEPEPDNDAGEDYWAPTIASDGWLEGPAARRWAVLAHAWLELDRFPWMIGLRDVNDKPLAALSAELRTAHAVPDRRAILAVTAEFPPGTAITAADVARVLSWRMPRRRRHFRIEAVERTLSEAAALGIVGRGALTSAGRALLHGTVADAEAEMDAALPEPVDHVLVQADLTVVAPGPLVPELRERIALVADIESAGAATVYRIGEGSVRRALDAGMTAAELHQLFTAHSRTPVPQSLTYLIDDVARRHGRLRAGMAQSFVRSEDPALLAEVLAAPVAAELALRAVAPTVAISQAPLGEVLERLRAAGFSPAGEDSSGAIVDLRPRGARLSTRPNERHAWRPTPPSAEQLRLLVGELRAGEKAARSRSGQRVRSDGTRTSTAATLALLQLAVRVRRPVHIGYVDAQGVATQRIVEPVRVAGGQLDATDPDTGAIRHFTLHRIASVALVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7D3</accession>
    <name>A0A231H7D3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dapE_1</name>
        <name evidence="2" type="ORF">B7C42_02723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777201.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44769">
        <property type="protein sequence ID" value="OXR44769"/>
        <property type="gene ID" value="B7C42_02723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="202"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="452" mass="48737" checksum="8656E8A4300BEDDE" modified="2017-10-25" version="1">MTATGTTATTVDDATAQRLAAALRCVTVSRDDADADEVEFDRLASLLDTEFPLVHTHLELERFGHSRLYRWPGTEPGTAAVLLAHQDVVPVDDEQRWTHPPFAGVVDDEFIWGRGAIDDKSRVLAILEAAESLLAEGRRPRRTVYFAFGHDEEIFGRAGATRMAARLRELEVRADLLLDEGGVITQGVADGATAPVASIMLGEKGWATVQLSTTDTGGHSSMPGRETAVGRIARAVARIQDHPMPLRMTPVIADMLARMRPAMAEPRRSALRLAPIAGGVITRMMAARPQTEALVRTTTAPTVIRGGVKANVLPQRAEALVNFRILPGDSVSGVLDHCRRVVADPRVVIEVLGTASEPSRITGPGPAFDVIADITRAVVPDAVVTTGIVPGATDSRHYDGLATTRCNFAPIVVDAADLERIHGTDERLSRANYARLIEFNRRVLAHYTSPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7I4</accession>
    <name>A0A231H7I4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multidrug resistance ABC transporter ATP-binding/permease protein BmrA</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">bmrA</name>
        <name evidence="11" type="ORF">B7C42_03511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44717">
        <property type="protein sequence ID" value="OXR44717"/>
        <property type="gene ID" value="B7C42_03511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="53"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="377"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="409"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR44717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="612" mass="65498" checksum="9FBA4730877FDD30" modified="2017-10-25" version="1">MSANTLSRPRAVGSNENGGKMSADDSGVRQGDSWPRRVGALLRILVPQRRSLLAATALLLVGTGLSLAQPLLAGQVVRDASSGATIAWSLAALVGAYLLYAVADTGGTYILERSSESVLLSVRRRLTGHLLRLRITTLESQRVGDLISRVTLDSTVIRNAVGSSLVQIVTGAITLVGTVAVMIYLDWLLFSIVFVTVGVAAGAMLLVMTRIEVASVRLQESVGALSADIERALNGVRTVKVNNAEDREHERLTELAGAAFAAGVRAARLKALGNPAMHLAVTGSFVVSLLVGGVRVANHQMELSSLVTMMLLAMNLLIPVGDLFNGSVGLQKALGALSRIESTLSLPAEDVDESAHDGLEPAGSVIEPYSENGHPALEFRDVRFSYDERPILHGVSFSVPPRGHVALVGHSGAGKSTVFSLVSRFYNPDTGDILLGGRSYAGRPRRLWRSEISLLEQNAPLLFGSLRDNLTYRQPGLGDEDLRRATELAGLADLLARLPRGLDTPVGEHGVLLSGGERQRVALARALIRRPVLMLLDEPTAMLDAETEKALNVTIRNVRKECALLVIAHRLSTIREADTVLFLKDGRIVDSGPHDELVARNADYRQLVGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7J7</accession>
    <name>A0A231H7J7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44762">
        <property type="protein sequence ID" value="OXR44762"/>
        <property type="gene ID" value="B7C42_02716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="30158" checksum="4CDAC0DBB0B3D706" modified="2017-10-25" version="1">MTVMTQPRDGELAGRAVGRIGYGAMQLESGADGVAVLRRAVELGVGHIDTAGFYGNGSVNALLREALHPYPDDLLLVDKVGAVHTDGGLVPAQQPGQLRAAVEADLRALDAEQLAVVNLRRVDAPPGIVATGDQIVDLDDQLAELTALRDEGKIGAIGLSNVTVEQLRHAAPAGIACVQNLYNLLERDEEPLLAECCSRGIAFVPYFPLGSGFPGRPKVADDDVVRDIAGRLGATPSQVGLAWLLARDPHILLIPGTRSLDHLEQNMAAREVELDAALLAALDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Q1</accession>
    <name>A0A231H7Q1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44746">
        <property type="protein sequence ID" value="OXR44746"/>
        <property type="gene ID" value="B7C42_02700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21970" checksum="36A4BB1ED2C48098" modified="2017-10-25" version="1">MPVLGVEPDARMADFARRDGLRVEVARLEEWDPAGRVFDAVVSGTAWHWIDPVEGARKAAQALRPSGRLALFWHVFQLPPVVAEAFAEVYRRLLPDSPFRPPARPGRAVDPYEPILVNSANGIRDAGGFGDVQRWRFDWEHRYTRDEWLDQMPTQGTLTQAPAEVVDQVLAGVGEAIDAMGGGFTMSYATMVLTAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Q3</accession>
    <name>A0A231H7Q3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyco_hydro_19_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44964">
        <property type="protein sequence ID" value="OXR44964"/>
        <property type="gene ID" value="B7C42_02921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011280554" description="Glyco_hydro_19_cat domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_19_cat" evidence="3">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="26348" checksum="5BD1E866559F04EE" modified="2017-10-25" version="1">MSSKLARRTSVTSLVRTAGAVAAAAAAVAAITTAAGVSESAKPDAVALHALSTPVVPAAPAAAAPAPAPAPQPSAAPAPQPIAAPAALPGADQAHVSAWLPQINTAMAAAGIDDTPQRAAAFLAQIGQETDGFATLTEYSDGSAYDGRADLGNTEPGDGPKYKGRGALQLTGRHNYELASQALGVDFVNHPELVADPQYAFATAAWYWTTHNLNAVADNAHPQNPASIDPVSQIINGGSNGRDVRRDHFIQVCQVLKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Z2</accession>
    <name>A0A231H7Z2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadE_2</name>
        <name evidence="4" type="synonym">nadE</name>
        <name evidence="9" type="ORF">B7C42_03011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45054">
        <property type="protein sequence ID" value="OXR45054"/>
        <property type="gene ID" value="B7C42_03011"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="30582" checksum="924A7A25B72A19FE" modified="2017-10-25" version="1">MGNLREQIIAELGVAAGIEPKVEVRRRVEFLADYLSSTPATGFVLGISGGQDSTLTGKLCQLAAEELRARGREATFVAVRLPYGTQADAEDAEVALDFIRPDRSVEVNVKPGADAVAAATAEGVRKLLGDQAQLRDFVRGNIKARERMVIQYAVAGQLNLLVVGTDHAAEAVTGFFTKYGDGGVDITPLTGLTKRQGAALLQELGAPPRLWQKVPTADLEDDRPALPDEEALGLKYSQIDDYLEGKDVSPEVAERVEEIYRNTRHKRTVPVTPLDTWWKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H802</accession>
    <name>A0A231H802_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45064">
        <property type="protein sequence ID" value="OXR45064"/>
        <property type="gene ID" value="B7C42_03021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012149937" evidence="1">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="13683" checksum="E60BFE3853AA4D07" modified="2017-10-25" version="1">MRGRTFVIAGTVASAVTMLGSGTAAADPATTIPGDGMYRVGVDIAPGIYQSAGPADPAHDCSWERLWKIPEPGDPPDPNAAIVASDRTHTTPVRVLIKSSDVAFASANCGGWVLMPAPPPTGSYGPGGLFGSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H809</accession>
    <name>A0A231H809_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="3 6">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bfmBAB</name>
        <name evidence="8" type="ORF">B7C42_02842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 6"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44887">
        <property type="protein sequence ID" value="OXR44887"/>
        <property type="gene ID" value="B7C42_02842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="PTHR11624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="35401" checksum="BBFF6429269CE2A9" modified="2017-10-25" version="1">MPVMTYREALRETLREEMRRDDDIFLIGEEIGVFEGSYKITAGLLNEFGDKRVRDTPIAEEGFVGAAIGAAMLGLRPVVEIMTINFSLLALDQIVNHAAKIYGMFGGQTSVPMVIRTPGGGGQQLGATHSQNIELYYAFVPGLKVVAPSTPADARALLKAAIDDDDPVLFLENLSLYNTKGEVPEGLSPAQIGKAAVTRKGTDITLIGYSRMATVCTQVADKLAAEGISAEVIDLRSLRPLDRDTLVHSVRTTGCAVIGEDDWLTYGIGAEIAASISDGAFDYLDAPVRRVAMAEVPLPYAKPLEKLALPSVESLYTAAVETLAAVGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8A4</accession>
    <name>A0A231H8A4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="3">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fabH_4</name>
        <name evidence="3" type="ORF">B7C42_03025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45068">
        <property type="protein sequence ID" value="OXR45068"/>
        <property type="gene ID" value="B7C42_03025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="118"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="257"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="38222" checksum="6CC3B208F18538C2" modified="2017-10-25" version="1">MPHSRFEAIGAYLPEKRVTTEELISRLAVPPAFDLEKITGVRERRVHDTRPESYEDSFVLAGKALDECLSRSQYSGSEIEAVISTSITRSKDADKIYMEPSFASALAQRIGANNAITFDLSNACAGMLSGTYILDRMIRSGMVRNGIVVSGEAITPIADTAVREISDKYDLQFASLTVGDSAAAVVLDRSVDEADRIDYIELVTASEFSHLCLGMPSDKSQGVALYTDNRKMHNEARFLLWTDSQRMFYEKRGTTFAEENFDFVIHHQFGAAAIPYMNAIAEREFGAPMPPDLNVLAEYGNTSSTSHFIVLHDHLSRGEIPAGSKLLMVPAASGVVGGFLSTTISSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8D2</accession>
    <name>A0A231H8D2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45095">
        <property type="protein sequence ID" value="OXR45095"/>
        <property type="gene ID" value="B7C42_03052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="19283" checksum="0050BC0C1EEA81D0" modified="2017-10-25" version="1">MEQAQSAGGREDRDREWDREVRGGETETEQLDRNLTSLIQELRVVQTGVQLLTGFLLTLPFQARFTVMSTPMRGLYLAVVAASIAATVFLIAPVAAHRILFRQHRLGSVVRTAHTFALVGLALLGLALTGVAVLIFDTVAGAVAATVIGVCFAVLFLLTWFAHPWRERRRGVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Z0</accession>
    <name>A0A231H8Z0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782371.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45196">
        <property type="protein sequence ID" value="OXR45196"/>
        <property type="gene ID" value="B7C42_02321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="178" mass="19476" checksum="05C2CC4B3B27213C" modified="2017-10-25" version="1">MAAPRPLPLDPIEEAHRQWTSHGWGDVADGMAAVTSLVRAQQIVMARVDEALRPSGLTFSRYELLTLLGFSKTGALPMATASARLQVHPTSVTNTVDRLEAAQLVKRVPHPSDRRATLIEITAAGRDLAAAATRELNEKVFARPGLPPERLHLLLQLLAEFRREAGDFDSGDTPTRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H973</accession>
    <name>A0A231H973_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45399">
        <property type="protein sequence ID" value="OXR45399"/>
        <property type="gene ID" value="B7C42_02524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="821" mass="86673" checksum="C9AA04F4BF5D9E1D" modified="2017-10-25" version="1">MGIEIPTELQWVAKYVVGAGDWPKGDETAMRRLADGWDQLADALTEIQTDAGSVTTSALAAVDGKTHEAIKEFWDQVAGDKGLWPGLIEEVKGLSKDLDDTATDIEHTKYVIIATLVILAIQMIQAIATACTGIGAPAAAAEEAAAQVAARLTIRQIIKWLIQKISTRALAKAAIIGVTQGAGVDAGASLLQMAQGKRGGFTGEEVKGLFAESVSGAVGGAVGAKLGSDGLAKGLVDKAGSTAGKFAARTAADAVGGAVGSVAGTAASVPFGGKFEIDPTTLATSSVAGAAQGAVGQVHEGRTAPASHESGTTDAGDTSAQPSPHTSEPAPAGTETGTTAHNTDSAPAPDRSAQPDHGNGPPHHTENTAPQHNTPTMDGSPAPHTAGTENGPSGHPAPVEHSVPEQSPRPGSSLNWDTDSPAPAGTTHPGASETSPSHDSPPPDHAAPQHPDASSPPHDAPATTRPGTDQPGSPHSDPATPPSAAHPDSPAAAPDPSRHPDAGTPVGRHDSPSPQPDPAQPTATPHGSSVTRPQRRLPAATERRLRPRPPRQPRTPTPPRLRRRRRPPRWGRWDLSVQPVVKVRIDRTPQLTLRLTRIHRTPILDRQRRTSDPKPHRARTIPGPRATTREPTLPRRAGPSLRVRRHPRRARRPARSRIVTHPARPPPTTLRRALDRSRPHRHALRSRAAHAFRMTETGTRRTGIPPSRLSSDRPALPPMVRALRLRTELGHVSPPMCPVVVPHTRVTQKPRPTAPASNTRATTRSPHPTTVPMRNRPNQRGPTPTAARRRNRPQRRRSRPRTARVSTPRCTHTSPVTTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H988</accession>
    <name>A0A231H988_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Erythronolide synthase, modules 5 and 6</fullName>
            <ecNumber evidence="6">2.3.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eryA_2</name>
        <name evidence="6" type="ORF">B7C42_02639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.94" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45514">
        <property type="protein sequence ID" value="OXR45514"/>
        <property type="gene ID" value="B7C42_02639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047879">
        <property type="term" value="F:erythronolide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="942"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1014" mass="107099" checksum="4CDE5F922821DFF7" modified="2017-10-25" version="1">MSSYRLPDGSIPILLSSDNPDLLGAEAAAIADYLAGHPEVTPDRVADMLFRTRSPRRHRALVMAGAQTDVIAALRAVADGHPHPAVVRSERAASAQRVAYVFPGQGSQRPGMGAMLYEHSSAYRDAVDECDKVFHDLYGWSPRAYLLEADRQADDKALTVQPALFMQMVGVAAMWQAAGVTPRVTVGHSQGEIAAAYVSGAQTLRDAVRIVTTRAQIVDSMELTGYSMAVLGVDRDECEDLIARQADFVELSVINSRHIIAISGERTAVVDIVETLNAAGKFAKEIRVQYPAHTSFVATAREPLSGTVSSEMDNAAFLDADIECFGATFGDRLHSGLSIVDYWYLNLRNRVRFDLAVKKAAAAGATTFVEISEHPTLMLAIQENLSEIPGQREFQALGTSRRTAEDLREFTRNLATVAVHDANYRWEALREPGDGGVPALPLLDFPNTRMSAKSLWAPFDYARAAHKPLADSDSDDSTVAPQRVVETWTRLQRRTMVPPRTFAVIDPAGANEDLAAAVRAAAPRQGATVAEPGSGTRPDTVVVLAPPSSADGPVHDVAEFLGARAWLDDLDGIGDIWLVTSGGEQVVESDLPDPFHAAVQAGFRCLAAEHVGVAFRHADLGTGADAAAAAKALLGAIHIAAEPELAVRDGGFYAKRLILDDTAGDAPLRAEELREVVIVGGTGKLGLDFCAQFAAAGAGRITLISRSGGTAAAGARIAEIGARYDTEVVVRRCDAGDAEALGALAAEYAASPATLIVHAAVDYEAAAADPDPATIRAAAAAKSVVLHNLVRMFPRTDDGRVVVCSSLSATLGGRGHMVYSAINRMLDAQAAHYRAEGIRCSSVQWGLWRAVGADHAEALARISGTGLLPMDPAVAVAAGFAPRAANVLVAAAQWGRIRDLFSVFGFAPLFAELPEDEPAPVSPVAQPAAAPVPAADVAAGSRDVADSVRDALRVVMGLEPEEAVDGSVPLVALGLDSLQALDLRKRVEAELRRDLPVTAILGGASLDEVVALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9H3</accession>
    <name>A0A231H9H3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ORF">B7C42_02577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030513443.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45452">
        <property type="protein sequence ID" value="OXR45452"/>
        <property type="gene ID" value="B7C42_02577"/>
    </dbReference>
    <dbReference type="GeneID" id="66719006"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="14176" checksum="EC6362AD810B88FF" modified="2017-10-25" version="1">MARLMGVDLPREKRMEIALTYIFGIGRTRAKEILDATGVSPDLRSKDLSDDDVTRLRDYIEASEFKVEGDLRREVQADIRRKIEIGCYQGIRHRRHLPVRGQRTKTNARTRKGPKKTVAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9J2</accession>
    <name>A0A231H9J2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sensor histidine kinase LiaS</fullName>
            <ecNumber evidence="9">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">liaS_3</name>
        <name evidence="9" type="ORF">B7C42_02492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45367">
        <property type="protein sequence ID" value="OXR45367"/>
        <property type="gene ID" value="B7C42_02492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="508" mass="53637" checksum="9E644F9290AA238F" modified="2017-10-25" version="1">MYPSMPAFDARSGFDGRVGFEPRAGVDGLGPDGRGADPVLEQPRLLRRSGGRVVGGVAGGIADHLGVDVFKVRMAFVLLSALMGAGIVAYGLLWIFTSSGADGPPPTASERRQAVGLVLLGLALSVSMAWLFNGTAARVVAPIIVVAVGAALVWREFDAEGPRSILGLPARPTVLTWTRILAGATLIVVGLGVVVLARINLSSLGSALIAVAVTLIGVGLLTVPLWLRMMHALNAERSARIRNEEREEIASHLHDSVLQTLALIQRQADDPQEVARLARSQERELRKWLFEDSMPAQSSLAAALRTIAGEVEDQHGVQVTPVTVGDVSMDVGDTGFGLPKEHFTALLGATREALVNAAKHAGVPTIDVFAEVEPHQVSIFVRDRGTGFDPAAVPADRQGLAKSIHARIERRGGTVEVQTAPGRGTEVRIMMPRKDSEGQGETGGFDGAETEMSTAGDADLAGAQGGPQQAETQQTETQQTEPQQAEPQQAEAGRPRGETAETGPRRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9K9</accession>
    <name>A0A231H9K9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acryloyl-CoA reductase (NADH)</fullName>
            <ecNumber evidence="6">1.3.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acrC_1</name>
        <name evidence="6" type="ORF">B7C42_01995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.95" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45703">
        <property type="protein sequence ID" value="OXR45703"/>
        <property type="gene ID" value="B7C42_01995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="192"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="35820" checksum="6E2900B69EA6F937" modified="2017-10-25" version="1">MLLEFDSEQRLWRDTVREAVGKQCPASLIREIADKGGDPMPLWRTYIELGWTELTGDAAAVALAIVLEELGRATDPTPYLATMTQFAPLAPEFADPAVAGTAVYDGVDAVLDADGWVLDGTAHHVLDGDRAEQFAVVTEAGVFVVPAAEVQVRRSAVFDPVLHIAEVRFDGVRAGHDRRGTVDVARARQFAATGMALTVVGACRRILDLVLDHVRARHQFGVPIGSLQAVKHKAADMHVAIERARALAYFAALTIAEDDPRRALAASMAKAGAGECQNLVFRNGLQLFGAMGFTWENDLQFALKRAQAGELMLGGAAEHRALIAEECRATEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA03</accession>
    <name>A0A231HA03_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45576">
        <property type="protein sequence ID" value="OXR45576"/>
        <property type="gene ID" value="B7C42_01868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="37" mass="4020" checksum="24418E007E2C1938" modified="2017-10-25" version="1">MIVEEPGQLIDRGRVVGKLAGKPGERCHRGEDANMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC1</accession>
    <name>A0A231HAC1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein LiaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">liaR_2</name>
        <name evidence="3" type="ORF">B7C42_02067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043678.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45775">
        <property type="protein sequence ID" value="OXR45775"/>
        <property type="gene ID" value="B7C42_02067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="277"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="347" mass="37470" checksum="E59E8E697BAD5461" modified="2017-10-25" version="1">MVRAEEQAIHRVRTVGGEVACSVVGSGPALLIGGWWCSHLLLNWKDPLFRAFMSRLATRFTVIRYDQPGRGMSATAAPVDPDGEIAVTAEIVDALGFERVAVLGASSGSAVAAGLAARLPRRVHRLVLYGSFARGADIAPEGARRALVDAISAHWGLGSRLLADVFVPGADSAERERFARFQRLSATAEQAARSLSATYELDATEYLAAVTVPTTVLHRRDDRAVPFALGVDVARRVRRATFVELYGEDHFPWRGDATAVADAILRGLGYPVRSRPPPPGPEAVTDREREILRLVAEGLTDAQIGERLTLSPHTVHRHVANARIKLGVRSRAAASAAIRTDRPDRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC8</accession>
    <name>A0A231HAC8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadA_5</name>
        <name evidence="6" type="ORF">B7C42_01988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45696">
        <property type="protein sequence ID" value="OXR45696"/>
        <property type="gene ID" value="B7C42_01988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="258"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="39106" checksum="9FC01C5138238C7E" modified="2017-10-25" version="1">MPEAVIVSAVRTPIGTARKGTLRDTNAFDLAHHVVAAVARDIDPGRVDDVVLGEGRYGGGVLARHAAVTAGLTTVPGLAANRHCAAGMAAVQSAAAGIRSGMDELVIAGGVNSDSTGPRVRFRVGADEWIDPWVSPSHPNRPDAPNLDMSITVGWNTAVKAGISRAEMDAWALRSHRNAIAAIDEGRLEEEIVPIETPHGEFSVDEHPRRDTSLERLAGLKVLHPEIEGFSVTAGNASGSNDGAAALAIASDRLGLPALGVIRSWASVGVDPADTGLAPIEAITKAVARAGISLSEVKLIEINEAFASVPLAAVKALDLDPERVNYSGSGCSLGHPVAATGARMIVTLVHELRRRGGGLGIAALCAGGGMGSATVVEVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAH5</accession>
    <name>A0A231HAH5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45848">
        <property type="protein sequence ID" value="OXR45848"/>
        <property type="gene ID" value="B7C42_02140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280101" evidence="1">
        <location>
            <begin position="40"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="31073" checksum="31D2FC452C51B927" modified="2017-10-25" version="1">MQRIGLAGIGRRRGANCRGMSIVAALVGLCIVSLGVAQTAEGEPGANAADTGFAVPFSGAPGYEQVAPTQMVRPDQLNQPLGEAAADRVAAQIGLDRAAALTDQQYQDLSSGGGVGGDRDAANVINACVDILANTVGRPIYSDVAGQRTPSTLGSYGLYVNPGGMLESPANADAPTRQVNTLIAPGGYIGNWLRDNGATRSLVALYRSAYTVQAAYGFVAQQISGAAQLVTNTKGNVTTVVGMSMAPPLWIVNFALIYILKPSLAAAMPAYWAPIPGPVVDAVKASPTGRVPFAEYASFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB20</accession>
    <name>A0A231HB20_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781342.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46045">
        <property type="protein sequence ID" value="OXR46045"/>
        <property type="gene ID" value="B7C42_01008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="37"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="317" mass="35194" checksum="FE2049A4DFD5FB54" modified="2017-10-25" version="1">MTCPVSHETSTRAPAASGHAAAATPSAAVERFERVAGSVFLGLFGLGLYDQTMLPAVSAALEVTGRVRDEPWGRARRTAAADQILYQGEEADRLAEAERLLRLHRDVKGVGSDGVRYSALAPESWNWILYSAFFVQYHAYRTVTGDEPTAADDQAIWDAFRASTAPLHLPGRSTPIADYREMVEHYNRVVAEQLRRTPTLAAATGAIDAAPRPDFLPPIAEPLWRVAAPFIRHVIIVLGCGIMHPQVRELMPYPWTPRREREFHALATVLRVAYRALPAAVTDTALARNRRRYRRLVTKYRGMGLNSFAPDLVSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBB3</accession>
    <name>A0A231HBB3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoniazid-induced protein IniC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iniC</name>
        <name evidence="3" type="ORF">B7C42_01116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46151">
        <property type="protein sequence ID" value="OXR46151"/>
        <property type="gene ID" value="B7C42_01116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="2">
        <location>
            <begin position="72"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="553" mass="59026" checksum="DB5C5E422AF9A089" modified="2017-10-25" version="1">MRAGRSRNHGTGIPRLLGYGRRVSYQVSDQTPGIVGEARRLVSAARQAYAPRSRPAAMLGDCARRLDQPLRVALAGQLKAGKSTLLNALVGQDIAPTDATECTRMVTWYRHGPAPRVSALATDGASADVVVRRTPGADGLPGAHGLSFDLSALRWNAAGEHEVDHLDVQWPAATLARTTIIDTPGTSSLSREVSLRTSRLLTPDEDAAVTVPEADAVVYLLRRLDASDIGFLERIGAGGAARQGVSGPLGVIGVVSRADEIGAGRIDALHSAREVSARFATELERTGLCQAVIPVAGLLAFAGATLRQREFDAFETLARISVDDLSIALLSADRFAHPELPLPVPADLRAHLAARFGLFGIRMAVTLIRLGVRDSATLARELAERSGVEELRTVLDVQFAQRADQLKAHSALTAVARIVAAHPGTRADDLLPQINSLLADVHGFAELRLLGRLRTDELPLPADDVTELYRLIGGSGVAPHLRLGLPPDAPGGEVQAHAVAAVRKWRGRARHPLADRFTTEACLTAARSAEGIVDQLREPETTPMSRVRPPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBI3</accession>
    <name>A0A231HBI3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional xylanase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xynD</name>
        <name evidence="4" type="ORF">B7C42_01270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781598.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46304">
        <property type="protein sequence ID" value="OXR46304"/>
        <property type="gene ID" value="B7C42_01270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011229400" evidence="2">
        <location>
            <begin position="32"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="79"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="28927" checksum="335A4490AABBEBCB" modified="2017-10-25" version="1">MGDARPNRRQLLTLLAAGTAAALTGCTTAHSATGDRAKPAVAPVISPPAPPPPLLPPPPTGPKAVVPAGTMTALPGVGANLALTVDDGASPEVVGAYIRFARDTGARFTFFVTAVYDSWTVHRDALRPLVDSGQIQLGNHTWDHPALTKISGSAVADQLRRTKTFLHNTFGVDGTPYYRPPYGYHNAAVDRVAADLGYTVPTLWFGSLSDSSIVTEDFLMQMAAKYFNPQAIVIGHANHPAVTHCYGRLVDIIRERRLSMVTLDDVLSPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBR8</accession>
    <name>A0A231HBR8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trehalose transport system permease protein SugB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sugB_1</name>
        <name evidence="6" type="ORF">B7C42_01287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036507022.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46321">
        <property type="protein sequence ID" value="OXR46321"/>
        <property type="gene ID" value="B7C42_01287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="30834" checksum="2E8D5EA2C3B18394" modified="2017-10-25" version="1">MTTATSGRKPWRSARVYVGALIVLIWGLAPFYWMAVTAFRDPDYTFDNTPWPTHVTFENFRNAFDTSRGNDFGRALTNSVVIGAATTVIALLIGMMAAYALARMAFRGKTLVAGLILSASMFPVVVLVTPLFQLFTNIGWIGHYQAMIIPNISFVLPMTVYVLASFFAELPWELEEAARIDGASRFQAFRLVMLPLAAPAVFTTAILAFIAAVNEYLLASLLSVDRTEPVTVAIARFSGNDPLVQPYAAIMAAGIIVTVPLVIMVLLFQRRIISGLTAGGVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBU2</accession>
    <name>A0A231HBU2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46318">
        <property type="protein sequence ID" value="OXR46318"/>
        <property type="gene ID" value="B7C42_01284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="2">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="30597" checksum="22CB719035AA8A71" modified="2017-10-25" version="1">MSTQMPQDKLLTRIGGLLRQAESTDNEHEAEAFMAAAQRLATRSSIDLAVARAHIAGRERRPTPVQKVVPIGEPGKKGLRTYVQLFVAIAAANDVRCDVTRTSTQVYAYGFDTDIATCEALYTSLLVQMVRASDHYIKSGAYRSATVEKIVVETRWGRTVQRRIQAPVAAVTARLNFQMAFADRIGRRLAQVKADVEAEAVDADTTAAESAGTALALRNKDLELTDFYSRTSEARGTWRGPQESTGYSPAARRAGDRAGRTARLGLSPELPSARGTLEAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC50</accession>
    <name>A0A231HC50_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036507131.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46326">
        <property type="protein sequence ID" value="OXR46326"/>
        <property type="gene ID" value="B7C42_01292"/>
    </dbReference>
    <dbReference type="GeneID" id="66717834"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="3">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="21058" checksum="858ECC1EC04F5C92" modified="2017-10-25" version="1">MLELAILGLLLESPMHGYELRKRLTGLLGPFRAFSYGSLYPTLRRMQTDGLIAEESPAGAVTRRARRVYQLTESGRERFGELLADTGPQNYTDDGFGVHLAFFSRTPAEARMRILEGRRRQVEERREGLREAIKRASGTLDRYTRQLHQLGLESSEREVRWLNELIAAEQSMKAAPQKEGNVGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCB0</accession>
    <name>A0A231HCB0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775131.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46531">
        <property type="protein sequence ID" value="OXR46531"/>
        <property type="gene ID" value="B7C42_01501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="257" mass="27345" checksum="D1B1D8A951E8E5F8" modified="2017-10-25" version="1">MRRTITSAAPSAAERIRSACAHAESAVLALPGTDPIPTTVHHLRACGDVVVAVARNSAAVAAAAAEVGSPGVLELTDHAPLALREPVRALVWLRGRVRAVPGHAQRALASQVAGEYPHPGLLDVGHTSTLLRVVLESAVVADSAGAESVCPHDLRSADADPFWELEAAWLQHMDSDHADVIARLARHLPVRLRGGSVRPLAIDRYGVTLRVEGPDTDHDVRLPFHAPVDDVQQLSRAVRILAGCPFFDRMHGSDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCB5</accession>
    <name>A0A231HCB5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497026.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46583">
        <property type="protein sequence ID" value="OXR46583"/>
        <property type="gene ID" value="B7C42_01554"/>
    </dbReference>
    <dbReference type="GeneID" id="66718242"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046030">
        <property type="entry name" value="DUF5988"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19450">
        <property type="entry name" value="DUF5988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="7276" checksum="2744B7AA2164F297" modified="2017-10-25" version="1">MGSSPKAVLEGGPADLPHRIVPITPPGIELRVQNAGGYERFKSTPRRQDTPEGNLPVYEWIEHVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD16</accession>
    <name>A0A231HD16_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">clpP_2</name>
        <name evidence="3" type="ORF">B7C42_01640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46665">
        <property type="protein sequence ID" value="OXR46665"/>
        <property type="gene ID" value="B7C42_01640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012106">
        <property type="entry name" value="Phage_Mu_Gp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10123">
        <property type="entry name" value="Mu-like_Pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="422" mass="45187" checksum="F39C73E699235DF5" modified="2017-10-25" version="1">MNRDHFFEHMRTPRNSGKRDWYTIRNAVDGDAATARIDLYDEIDPFWGVSAADFVADLRALDAETIQLHINSPGGSVYDGIAIMNALRQHDARVVATIDGLAASAAGFIAVGGSDELIMAENSEFMAHEAWGIAIGNAADMTKMAGDLDRLSSNIASIYAAKAGGTVDDWRAVMEAETWYTAEEAVEAGLADRVAEPAKKSAAKASFDLAIFNYAGRRAAPAPRLHQSPSARVRAEVTPGKEGAMPDLIEGLRGVLGLPEDADEATVLAAVTERVDSAGAATGETTPGEPAEPTLQQITASAKRLNLTLVDKDQYDAVVAQAEQGAKAFAKMQKQHHEKVLNEALRTGRIAKAQRDAYAAQLERDAKKGLDDTEKFLMALPKNTVVPVEELGHAGEPDAPDIDAEYQATFAQITGVPYNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD67</accession>
    <name>A0A231HD67_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pbpG</name>
        <name evidence="11" type="ORF">B7C42_01850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46871">
        <property type="protein sequence ID" value="OXR46871"/>
        <property type="gene ID" value="B7C42_01850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="732"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="796"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="801"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="831" mass="87196" checksum="C63F0956DD70625F" modified="2017-10-25" version="1">MGPAQDRARNFWYARPCEGRATRGHDAPPTAHRACDGGPIRLGRVPISQTLARLAGACVLAAVLVAGLLFPLAGGFGYLSNRAADAVDNVSAELVAGTAPAVSTMVDATGAPIAWLYEQRRFEVPSDKISNDMKLAIVSIEDKRFAEHGGVDWQGTLRAFLTNTSSGEVQQGASTIDQQYVKNFQLLVVAKTDAERRAAIETTPARKLREIRMALTLEKELTKDEILTRYLNLVPFGNGSYGIQDAAQTYFGVDAKDLKVAQAAMLAGMVQSSSKLNPYTNPKGVLERRNTVLDTLIQNIPSRADEFRAAKEQPLGVLPEPKGLPRGCIAAGDRGYFCDYALQYLANAGISKDQMDKGGYLIRTTLDPAVQNSVKAAVTANTDPNLENIAEVMSIIAPGQDSHHILAMTSSRTYGLDQGAHQTVQPQPYSMVGDGAGSIFKIFTTAAAMEKGLGTSAQLDVPSFFAAKGMGNGGAPGCPPATYCVKNVGNYRSPESVTEALAQSPNTAFVKLIQDVGVTPTVDMAVRLGMRSYTEAGTSGHGNQSLADMIKQQNLGSFTLGPVAINPLELSNVAATLASGGKWCPPSPIAEVIDRDGKQVPLTQQACEQVVEPGLANTLANALSQDAVGGTAAGSAHAVGWNAPVSAKTGTTETHRSSAFLGFTNSMAGSAYIYGDSPTPGEICSFPLRTCGDGNLFGGNEPARSWFGGIKPVLDKFPPPALPPLDDKYVRGSNNAQIPDVNGMSESEARSVLIGAGFQVSTVTTPGSAAKGTVTATTPNGSAIPGSVITVLVSDGTQREIPRPGPPPAPPALPGLPQIPRLPPIPIPIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDV7</accession>
    <name>A0A231HDV7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pepN_1</name>
        <name evidence="16" type="ORF">B7C42_00194</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47074">
        <property type="protein sequence ID" value="OXR47074"/>
        <property type="gene ID" value="B7C42_00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="117"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="241"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="535"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR47074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="864" mass="94515" checksum="A01F416C139693D6" modified="2017-10-25" version="1">MSAPNLTREQAIARAATISVENYRVELDLTGQPTGPAANAGETFFSRSTVTFTATPGAQTFIDIVAAGVRSAVLNGTELDISGYDESQGLTLTDLAENNVLVVEADCVYSHTGEGLHRFVDPTDDKVYLYSQFETADAKRMFACFDQPDLKATYDMTVTAPADWEVISNGAATATRTVGEVVEHTFATTPRMSTYLVALIAGPYAKWIDVYTDDQSTIPLGIYCRASLAEFMDAERLFTETKQGFAFYHRNFGVPYVFGKYDQLFVPEFNAGAMENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMKWWDDLWLNESFATFASVLCQAEATEYTGAWTTFANVEKSWAYRQDQLPSTHPIAADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLEPFLAGLRDYFAAHAFGNATFDDLVGALEKSSGRDLSDWGAQWLKTTGLNTLRPDFEVDADGKFTRFAVVQGGAEPGAGEHRVHRLAIGVYDDRDGKLVRTKRVELDLDAAERTEVAELVGVERGQLVLVNDDDLTYCSLRLDPQSLDTVIARIADIAESLPRTLCWSAAWEMTRQAEMRARDFVALVQRGIGAETEIGVVQRLLMQAQTALASYADPEWADQTGWPAFADRLLELARAAEPGSDHQLAFVNALTGARLSPWHSEVLGTLLLDSDPAAAALPGLAVDTDLRWRIVGALAAAGQLDAESTDTPVIDAELERDPTAAGRRQAAAAATARPQAEVKEKAWHTVMDDDSVPNITARAIVGGFAPVGQGELLAPYVQRYFDEIASVWERRSSEVAQTVVIGLYPHWAISEEAVAVADKFLADEHPPALRRLVIEGKAGIERSLRARAADIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDX0</accession>
    <name>A0A231HDX0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47022">
        <property type="protein sequence ID" value="OXR47022"/>
        <property type="gene ID" value="B7C42_00140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="28371" checksum="4CD1DDCE17322A97" modified="2017-10-25" version="1">MRALSGVYSRLFGAGFRRQWNYRSAVFAGLAANVVFGLIRAAVMITAARSAPGFGGYTGASIGAYVWLSQAMLGALRVMGPPHDIAERVRTGDVAVDLQRPIDIQFFYLATDLGGSSCTLALRGLPSVATGLITAQLVLPGTFAPYLLGAVSVVAAVTLSLLLLFSVSLLGFWLIETRGIRMLYQILSTFFAGLYVPVHLFPAPLAAAARLTPFPWLLQGPVDVLSGRATGSAAWSVIGMQMLWIAIAIGIGRTLIAAGRRKLEVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE55</accession>
    <name>A0A231HE55_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47092">
        <property type="protein sequence ID" value="OXR47092"/>
        <property type="gene ID" value="B7C42_00214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="14253" checksum="C61A0FDD08A5875B" modified="2017-10-25" version="1">MSEPSSKEITLAIRIDTARHAQLSWIAELRGTSLKAECFNAVDAHIEAAKNDPELMAKADAARAAIEEEARARQTAIANLFTASPPPPVNVEDAAGPDATAEAEETTDSAASQGNRRPRSRRATQQGDGEQVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE89</accession>
    <name>A0A231HE89_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">recO</name>
        <name evidence="10" type="ORF">B7C42_00415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47293">
        <property type="protein sequence ID" value="OXR47293"/>
        <property type="gene ID" value="B7C42_00415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="9">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="290" mass="31212" checksum="FA9E6EF7E814E136" modified="2017-10-25" version="1">MTGYVGGGGNVAPDRGPVAWGRGHVGVAWETMSVLLYRDQAIVLRQHKLGEADRIVTLLTRQHGLVRAVAKGVRRTRSKFGARLEPFAYIDVQLYPGRNLDTVTQVHTVEAFAADIVADYGRYTTACAVLETAERLAGEERAPAPRLHTLTAGALRAIAAGRRPHELILDAFLLRAMGFAGWAPALDECARCATPGPHRAFHVAAGGAVCVHCRPPGSATPAVGVLELMSALNRGDWDGLDVVAESVRRQASGLTAAHLQWHLERQLRTLPLIERSRPHEAAESPASRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEP9</accession>
    <name>A0A231HEP9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47344">
        <property type="protein sequence ID" value="OXR47344"/>
        <property type="gene ID" value="B7C42_00467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15315" checksum="BD9EDB553FB556BB" modified="2017-10-25" version="1">MAKLTVSVDVPIPPDRAWSHAANLGELDQWLIMHEAWRGRVPDELTAGTELVGIASVKGLRNRVRWTVRAAEPPRRLVLSGAGKGGTKLGLELLVAPNASGSAVTVDIDLGGRPLFGPIGATVARALRGDIERSLDRFVDLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEV0</accession>
    <name>A0A231HEV0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777089.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47236">
        <property type="protein sequence ID" value="OXR47236"/>
        <property type="gene ID" value="B7C42_00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12389" checksum="F9ECCDD4B3B75D7E" modified="2017-10-25" version="1">MSDLLRYCLRKPGAWRDEPWEGDVVAKVGDKIFAFVSPETVTLKCGRNRLEADELVHIHPEDVTASAYIGRYGWNTVRLGGSVSDAEVRELIDQSYAEVVAKLPKSKRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF09</accession>
    <name>A0A231HF09_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator PrpR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prpR</name>
        <name evidence="6" type="ORF">B7C42_00594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051024804.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47469">
        <property type="protein sequence ID" value="OXR47469"/>
        <property type="gene ID" value="B7C42_00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026281">
        <property type="entry name" value="HTH_RamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019251">
        <property type="entry name" value="Rv0465c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="470" mass="51734" checksum="6E72F0EA475023E6" modified="2017-10-25" version="1">MYAGARLRRLREERRMTQAALAKSLELSPSYLNQLERDQRPLTIPVLLKLNSTFDLDVQFFAADSDARLVSDLHEVLVEAAGGTAPPAAEVEDLATRLPEVAKTIVAMHRRLRATTDQLDLLSSKVAAPAGAPGVPMPYEDVRDFFYDHHNHIPQLDLAAERLFDECGLTIGSIDRQLARVAEERAGVTVLVRGDGADPAVPKRRYDPETRTLILARRLRPGQRAFQIATTLAFLLHGDLLDEVLDATPSLVGESRALARVGLANYFAGAVVLPYGKFLRSAEELSYDIDLLSLRFEVGFETVCHRLSTLQRQGQRGVPFFFVRTDRAGNISKRQSATAFHFSRVGGSCPLWVVHEAFSHPGRILTQVAAMPDGRRYLWIARTTYPSPHGFGTATKEFAVGLGCDIEYADRLVYSQGLQLDEPAAAVPIGAGCKVCERPACPQRAFPQIGRPLAVTENSSVDLPYPPAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFA3</accession>
    <name>A0A231HFA3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acylamidase</fullName>
            <ecNumber evidence="2">3.5.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aam</name>
        <name evidence="2" type="ORF">B7C42_00776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.13" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47651">
        <property type="protein sequence ID" value="OXR47651"/>
        <property type="gene ID" value="B7C42_00776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047680">
        <property type="term" value="F:aryl-acylamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="463" mass="47895" checksum="93430E8C6EA79A35" modified="2017-10-25" version="1">MAHPGTGTDPAAMTAAELASAYSAGALSPVEATQAALDAIAARDDALNAYCLVDSERALIQAKESEIRWNNGHAQGLLDGVPISIKDVFLTQGWPTLRGSTSIRPDAPWPVDSPATARLREDGLVFLGKTTTPELAWKATTDSALTGITRNPVDPALTSGGSSGGSAVAVAAGMGPVSIGTDGGGSVRIPASFCGVVGFKPTHGRIPLYPASPFGPLAHAGPIARTVEDVALLMDILSLPDPRDPTAGAPPLTTFRGELQREVRGATVGYSANLGFAQVDPEVAAVVAAAVRKLDEAGLRVVEADPGFADPREAFERMWAAGAATLLSTFPPGTRDRVDPGLGAMWDRGLALGAVDYLNARAVAAEIGIAMGAFHTVYDVLITPTMPITAFEAGYDVPPGSSMDSWPQWTPFTYPFNLTQQPAISIPAGTTAAGMPVGLQIVGPRHSDDFVLALARFAELVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFN4</accession>
    <name>A0A231HFN4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_00819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47694">
        <property type="protein sequence ID" value="OXR47694"/>
        <property type="gene ID" value="B7C42_00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="37877" checksum="4C41A6934E2D3B2D" modified="2017-10-25" version="1">MNPEDELESSVLDPLDKQIVHGLVTDARIPFATLGAILGVSEQTVARRYRSMRERGILHVSGQVNAMPLGNTRWMLRVRSTPDKALRLAESLARLPDVSWVALLSTGSEVTCVSRPRSIEQRDALLLNVLPRASQVTGLMAYEIIHRFPLAEEWPRYSRLLTAEQLRQLGPRPAMNDQRGPDAPTDLSAADEAMLGVLARDGRASYARLAAETGWSPTRVARRMSELVTAGVLYFDLDFAVERMGYAVRASLWVRTRPAELDAVGRAIATHPETAFVAATTGPTNLVVSVVCRDSSHLYRYLTGRLGALDGIVDVEVTPTLRMLKQAQALMQTDRIAVVPTATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFZ2</accession>
    <name>A0A231HFZ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YlxR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47636">
        <property type="protein sequence ID" value="OXR47636"/>
        <property type="gene ID" value="B7C42_00761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13771" checksum="7CFF286ACC1C1AD2" modified="2017-10-25" version="1">MAAVQWTQAQRESSVSALSAQVGARVRTRTPGPVRTCVGCRKRELAADLLRVVAQSPGSAPDRDAVVAIVPDPRRRLPGRGAWLHPVSACLSMAERRRAFGRALRVSGKLDISALEHYVENRHEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG54</accession>
    <name>A0A231HG54_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042821.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47665">
        <property type="protein sequence ID" value="OXR47665"/>
        <property type="gene ID" value="B7C42_00790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="448" mass="48238" checksum="D5ACB7A5046B9F25" modified="2017-10-25" version="1">MARRGTFLQRQAQRIQRSALLVSVVTVVLGGLAIAGIAWWALWLVLGAKADTPNQLDLTKIALSVSAGVGGAVALVVAYRKQRDNERGRFAQLFGAAAAQLGSADVAVRMAGVYAMAGVADEFAARGMRQQCIDVLCGYLRLPYDPDEGATHLSSRKVTEEAGSSQVERAYQLRQNDREVRRTIVAVIASRLRPTAEISWSSYYFNFDDAVLEDVDFRGAVFAGRHTHLRGARFTGSRSANFTDVKFVGQHVTFHAAQFDNDVLFHNTHFATTAYTDHTARAGTSFVDAVFHRGADFTGAEFLGPGTRFLRARFAGESTSFSGASFGADMTDFRETRFEGGRTHVDDVRFAGAVTRFDDAVIRGSHITFANTRFDASRTVFDHARIGADGDSPHADFRGVTCRGSVSTEGAAIPGCPFGPATPEETPALEGVRDPDGAGPVVAGQPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSX9</accession>
    <name>A0A231GSX9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000085">
        <property type="protein sequence ID" value="OXR39688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39688">
        <property type="protein sequence ID" value="OXR39688"/>
        <property type="gene ID" value="B7C42_08234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="71" mass="7802" checksum="04039E45187EB8AD" modified="2017-10-25" version="1">MEDRQPTGSVPIGDIATLTPGQQMKAKVEVSWYTSAWGIDWYTTAWGDPVPSRLGKVGPVRLDLFSVPVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTA8</accession>
    <name>A0A231GTA8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000065">
        <property type="protein sequence ID" value="OXR39785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782122.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39785">
        <property type="protein sequence ID" value="OXR39785"/>
        <property type="gene ID" value="B7C42_08137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="21315" checksum="49CD8F6BB5EB6C93" modified="2017-10-25" version="1">MSIAICSSEMMISGPRGTGFAEAWMPRIVAERFTTSTKDGNVQRAPDPVIFIDAEMSWTNATGSDQQCWLSTHRAPRTIIATNPNTYALDDAVSSDIAVSPNAVDPYATEDGIGCRASITPFALNQINYGRFFRGWDDNVRFQSLGVVPAGQTAHIRYRALYTTPGQWRDPNQVLQVVRAYWVRLLLWAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTU3</accession>
    <name>A0A231GTU3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000044">
        <property type="protein sequence ID" value="OXR40043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40043">
        <property type="protein sequence ID" value="OXR40043"/>
        <property type="gene ID" value="B7C42_07888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="18388" checksum="D6C10B09315E35A2" modified="2017-10-25" version="1">MPGRSTPTSSKRRDTTTTTPAGDDSSIHEQRLTARASSGPHLLAWVAATRQTFTICNPGGHPVAHDRFHRDLLIDSDDVATETAALQAIWLAAHGKDLWGADVATFRIVTSRLVTDTDALHRAAVTSGLVLDLVVDATTNPATDHQLGVRVEWRRADLTCLIQHPRNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU26</accession>
    <name>A0A231GU26_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782764.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40055">
        <property type="protein sequence ID" value="OXR40055"/>
        <property type="gene ID" value="B7C42_07859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="63" mass="6795" checksum="B5C8FEA61EC49D92" modified="2017-10-25" version="1">MLEVGALVKKSADSDRVFEIVEIEDDARALIAPTGDTAHAPGSYPYWWPLRLLTPAEGTAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU91</accession>
    <name>A0A231GU91_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsK_2</name>
        <name evidence="4" type="ORF">B7C42_07708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041938.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40194">
        <property type="protein sequence ID" value="OXR40194"/>
        <property type="gene ID" value="B7C42_07708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="448" mass="48384" checksum="9E88BD317F0FCEE7" modified="2017-10-25" version="1">MSVVNMVPVAVSAASALVFAAYILPWGRRPATTTAHGLARDLEETSEVLRPAVLSFASTAHAQLMFSDLKLGSPEIGYPRVEWWDFSRYGLTVDLLMRGGQTLSDWSDDEMRSRIADYVGVDQVIASSPAPGWVRLELRVRDTLAEAVVTNIDTGTVTAAGVDLEAVPAGVREDGTPWLLRILYSHILVAGATGSGKGSVLWSILAGLGPAIKAGFVDVWLADPKGGVEFGVGENKLFVRFATDAPSILGVLEEAVQVMQERQARMRAAGLRKLVPSKDEPLILLIIDEAAALSSYAEREEQETFRRKTGMLQSQGRAVGVSVIAAVQDPSKEVMPNRQLFPTRIGLRLEEPTQIAMIHGQGARDRGALCDEIPEDTPGVGYVGEDGKKGFARVRAFWITDEQTKEIVERYSPAADVDFAPTQDYSDFDPDDLGDDIPGDGYTGPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUA8</accession>
    <name>A0A231GUA8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="8" type="ORF">B7C42_07725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498540.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40210">
        <property type="protein sequence ID" value="OXR40210"/>
        <property type="gene ID" value="B7C42_07725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="81" mass="8832" checksum="8594F9B70567636A" modified="2017-10-25" version="1">MKAGIHPAYVPTTVVCGCGNTFQTHSTKESGHITVEVCSQCHPFYTGKQKILDTGGRVARFEARYGKRAKKAEQSESSEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUP1</accession>
    <name>A0A231GUP1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909912.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40326">
        <property type="protein sequence ID" value="OXR40326"/>
        <property type="gene ID" value="B7C42_07587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17730" checksum="5BC1B0EEE0871969" modified="2017-10-25" version="1">MSTTPDVAALQGKASVALPMERAFAFFTESFGSWWPSAYHIGASEMADAILEPQVGGRWYERGVDGSECDWGRVLVWEPPHRLVVTWQITGHWQYDPDPERASEIEVRFTAEGPAQTTVTLEHRHIDRLVEGAAMAKTIVEGGGGWNSVLEAFAKTAEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUU6</accession>
    <name>A0A231GUU6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40338">
        <property type="protein sequence ID" value="OXR40338"/>
        <property type="gene ID" value="B7C42_07599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="17719" checksum="6E8E5A2A8E84CCC9" modified="2017-10-25" version="1">MSTVLTDPSTLPVQPSPSGFRTTREYERCLYEGLFGGCFYEPRTRALTIRTHRVRAIMAPEDLAEVAAGRMHGYLPIVTLVHRSGPGVWVLLTRPPASGDDLLALARRAKTRSIVMVGPGAELALPTAGVSRRRWRGPVPTAATIVGDFPAYAEVIEALTHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV50</accession>
    <name>A0A231GV50_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40503">
        <property type="protein sequence ID" value="OXR40503"/>
        <property type="gene ID" value="B7C42_07442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026835">
        <property type="entry name" value="YqcG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14410">
        <property type="entry name" value="GH-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="475" mass="50777" checksum="F2824663C67FCD4C" modified="2017-10-25" version="1">MVPPPIVVDPNGFTTAAQTYADIHGNSLVPAITELCTTLNACGGSAGSDNAGLAWSRDYDPVAYDTVDALGDLALACGQMHDLLQFSGANHANANSQSGPNADPNALVFPPGSLTVYNPPEPPNAFGGSDPEPTGWSWVKGAVQGQVWPNGHPDKLRSAAGAWRLMATKLRMATIALPGARSHIEAQQSPETQQALEQHDLVKGQFDSLAGTCDQLATSCDSYADSLHTTKTAIVKALVEMVALIAVDQAAGFVGAWLTGGGAEVAAQGGMALAISIYGARIATLIRALIGLAEVARVPVAVSQAIARGSEALIPLLRARPALAAADGAVAPGPFTTFANLRRPYLRQETTDAIEAKAEKWRRQGDSSDDWYTVESEPDVKVPIDKSYANKPGVTDLPKTPDGKYYVDAANGARYPVNPNWEYGHNSGFEHRRLLEEAQKQNMDQQQFNDYVNSHPDYFHIEDQTGNRSHRREQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV51</accession>
    <name>A0A231GV51_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40499">
        <property type="protein sequence ID" value="OXR40499"/>
        <property type="gene ID" value="B7C42_07438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="112"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="425" mass="45823" checksum="138C340EAD499376" modified="2017-10-25" version="1">MNLGRRYWNSLIRPVPVPTGAARGRTGYSFLQRYWASLTGYRLPEIVSATRSDEGGRASLQLGKPRANRKALGGWFTHVTAEQRNAEPSAPGSAQARGEWLVPAAPKTAALPVYLVVDESTSMAAYRDELQGGLASLIDTLRTATTAGANLRLAVLGFSDDVQSRLDLSDVREASSAPLMQVRGVANYRAVFEYLLRRIPADSERLRNEGHLVYRPVVYFVSKGQPTDASDESWHRQHAALVDRSRTRDAPNIVAFGIGAELTETMFEVATDPGLVFVAERGTSSTRALRGFLHSVATSLIPSGQTADAVDSNATVSLGVLLAEAGREESAETWWRRGADAGQLSAMFNLGSLLNKAGRHDEALAWLQKAAEAGHADAMTNLGSLLSKAGRHDEALAWLQKAAEAGHADAMTDLRTTTRKQEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVF9</accession>
    <name>A0A231GVF9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">betI_30</name>
        <name evidence="6" type="ORF">B7C42_07399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40461">
        <property type="protein sequence ID" value="OXR40461"/>
        <property type="gene ID" value="B7C42_07399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20552" checksum="C9BA00DE9E68326D" modified="2017-10-25" version="1">MTKSSYHHGDLRETLLTAAAEQIAADGVDAVSLRALAQRAGVSHAAPAHHFGNRQGLLTALAIRGYELLADELRGARDDFREMAVAYIRFARRHPGHFDVMFRHDLLRADDPELIAARTVSGEELRSGVAQLGVAESARPATELAAWSLVHGFASLWREGALTDSELGGADPEQLARQMVATVDFVGAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVL0</accession>
    <name>A0A231GVL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40511">
        <property type="protein sequence ID" value="OXR40511"/>
        <property type="gene ID" value="B7C42_07450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="459" mass="50029" checksum="0778134286410385" modified="2017-10-25" version="1">MVRGRAWTGFEAAALQEAMRYSVRDFAQMLGVELTTVANWRAGLSAVTPRTRTQAILDTAHRQRATPEDRERFTQILAEGEAAWRLRHGHGQREAGTDDPAPMSDAVVSSVAPEARTTDGPSAKLRDDGLQDTAQGSLEFARWATDASADQFSIDSLYFDLARIATTYVHKPLRPLLADLTDQRNVAWRLLGDRPRPQQTRDLLVLGGVAITILAHITDDLGNPFAAMQHTLAAERLAHQADHAALKAWIAGTQALITEWSGRPSKAMEFVRRASRNVPPGHQRVRLAALEARAAARAGKVDDARNALRRTRVAIDGTAASDDLQEIGGILTFPIPKAMYYTASALTLIGDHQEAERVALDAINAYETGAAEERSYGDEALARSDVAIARIARHDLDGAVDALTPVLKLPAPQRIQSIRDGLAQVEKHLVDNRHTTAPTAQHLRQEIAAFTPVALQALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW56</accession>
    <name>A0A231GW56_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40844">
        <property type="protein sequence ID" value="OXR40844"/>
        <property type="gene ID" value="B7C42_07128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="359" mass="37402" checksum="10438EC20916CE82" modified="2017-10-25" version="1">MIVATIRDMPAEDQGDLFLRHRGAVLDTLLSDPSFGSPEFAADEGPAAGPSATEYPNGVDSVADSDSIPSVRKVSSGPKASDRIMALLSGESPAGSSQLEFTSDFSERSARLGAAAEESEQRAGAAPESREKAADRTSADRPQFPQVVLAQLRKPKVALAVAAALALVLVLVLVTTGGKKSNPDQLAVVTPVAAAPPSSKPGAGPESAPSESSSAPIKVRSAQARCPAGSTDAMDAFSGEPGKAWSCVRAFKIDGQVMTIDLGKKYQVDSIGIVPGWDSVGSDGADQWNKYRTVSRVSYLFDDPTATRYTQQTLDQRSLVVTKMSPAVSASKITLTIQQSKGEPSINTTAISSIVITGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW85</accession>
    <name>A0A231GW85_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498834.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40838">
        <property type="protein sequence ID" value="OXR40838"/>
        <property type="gene ID" value="B7C42_07122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="12734" checksum="568B4575176A0CE4" modified="2017-10-25" version="1">MDDMADARPSAAERERALQELSQQLGAGRLTLPEFDERTALATRADTRVELAALFTDLPVVTPDPPAAPAPANPLPSLAVLAGAITVFAVVSAWAAGNWLWLLLIAAAPVAVVLWRVRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWE2</accession>
    <name>A0A231GWE2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heme-dependent peroxidase</fullName>
            <ecNumber evidence="4">1.11.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40947">
        <property type="protein sequence ID" value="OXR40947"/>
        <property type="gene ID" value="B7C42_06913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="26974" checksum="B0641C0CCFA7EB33" modified="2017-10-25" version="1">MEAMARLDYQALNSTIRYLMFSVFQVTPGVLGDQRDTVVKQAREFFDSLEERGVVVRGLYDVAGLRADADFMIWWHAERIEDLQAAYADFRRTTDLGRASTPVWSNAALHRPAEFNKSHIPAFLAGEEPGNYICVYPFVRSYDWYLLPDEERRRMLADHGKQARSYPDVRANTVASFALGDYEWILAFEAPELHRIVDLMRDLRATDARNHVREEIPFFSGPRVDVEQLVNALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF4</accession>
    <name>A0A231GWF4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic di-GMP phosphodiesterase Gmr</fullName>
            <ecNumber evidence="4">3.1.4.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmr_3</name>
        <name evidence="4" type="ORF">B7C42_07061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.52" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821401.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40926">
        <property type="protein sequence ID" value="OXR40926"/>
        <property type="gene ID" value="B7C42_07061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="121"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="196"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="278"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="433" mass="46909" checksum="93F286A8AFC8B1F7" modified="2017-10-25" version="1">MDDLSTALAQQWERALATITTHPSYADVEISFLRNLLEELHAGLTAEIFDAAAGSRVGAALAGAQLTDPAVPVVSAPVLHRLTEFSDHPDTGPRMAALLVAFGHGHHFLADAIRADDVEEDRRRFRLVFDHASIAIAIGDTNGVLLEANPHLADMIGVPVDSLRGISVYDFAHPDDQAAIRQMVYDDLVPARAGTAKIERRLQRADGSTGWATFAITYVRSAFGPDYLLAIGEDVTERHQLQEQLHYQARHDALTELPNRRHLLDTLRAVISTAGENDQMGLCFTDLDHFKEVNDRYGHGVGDQVLATVARRLHDSLQDDGCLVARIGGDEFVTLIPPPADTRRVSAVADRLRGALSHPLIVGGHRLHISASIGAVVTPVAGKDPEWLLDAADTSLYDAKSGARGNWILHTVHAAESADEGFDSDYPAAGNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF7</accession>
    <name>A0A231GWF7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A</fullName>
            <ecNumber evidence="4">1.14.14.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntaA_12</name>
        <name evidence="4" type="ORF">B7C42_07037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40902">
        <property type="protein sequence ID" value="OXR40902"/>
        <property type="gene ID" value="B7C42_07037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018529">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102977">
        <property type="term" value="F:nitrilotriacetate monooxygenase activity (FMN-dependent)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="414" mass="45110" checksum="39FD209F2F56A6F2" modified="2017-10-25" version="1">MSEYLHINVNILNAGVFGGSWRFPGTDPLASYGIDHYTSIAKKAEEATLDAVFLADGPALDPSVEHRPGNNLEPTTVLARIAARTERIGLIATLSSSYNDPVELARRLGDLDHLSGGRFGWNVVTTAGPVAARNFGRDAEPDHALRYRRAAEFVERVVASWAERTEFRSPQGRPVVVQAGGSSDGKRLAARVGEVIFSAEQDLGTARAFRTELREGARAFGRDPDDIVILPGLSTVVGSTEAEAARRRELLDELLPAAYARNRLAGQLGISLDGLADDERIPADLLPEPDDAGGSQTFYRVVKDIIDRERPTLRQLLKKLSGGGGHRIVVGTPEQIADDIERWFRAGAADGFNVMPDVLPSGFDDFADHVIPELRRRGLFRTEYDGRTLREHLGLGVPEVPVGVWDRGPLEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWM3</accession>
    <name>A0A231GWM3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor ComR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">comR_6</name>
        <name evidence="5" type="ORF">B7C42_06948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40982">
        <property type="protein sequence ID" value="OXR40982"/>
        <property type="gene ID" value="B7C42_06948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="22137" checksum="30050A79F5773EB1" modified="2017-10-25" version="1">MAERGRPRGFDRDVALRRAMEVFWEHGYEGAAMSDLTSAMGINSPSLYAAFGCKEQLFREAVELYGRTEGGYTARALETAPTARAAVEAMLRDNAAAYCDPATPRGCLVVVAGNTAGPRHGAVRDLLAERRRHTTEAVRQRLERGIHDGDLPADADIEGLADFYTAVLFGLSVQAGDGTDLQRLGRTIDRALQAWPKSVPAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX88</accession>
    <name>A0A231GX88_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41198">
        <property type="protein sequence ID" value="OXR41198"/>
        <property type="gene ID" value="B7C42_06596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="204" mass="22033" checksum="EDC8AFB06C3AB214" modified="2017-10-25" version="1">MDAAIGCLSERGYAAISQSLIAQRAGVTRGALHHHFPSFELLLTAAATRLAITRAAELDAAFGDLCRDSASISQCLDRLWSVHHNPTYTAMIEIVVAARSHPALAEDLRFLQSSLQTDLVAAQIYSSPWITRSRAAQQWAATALDGIAGLVIGTWSRAALDDRRAHWQRLRRHLIASAPPNHDGAAANPRHSSADACKPMTSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXA8</accession>
    <name>A0A231GXA8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD_binding_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41218">
        <property type="protein sequence ID" value="OXR41218"/>
        <property type="gene ID" value="B7C42_06616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059345" description="NAD_binding_2 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="29786" checksum="23CBEC54B832E386" modified="2017-10-25" version="1">MGAALAARFLVSGVATTVWNRTASKAAPLSEAGAHVALDPEEALWRSAVCVVCVEDYSQVRDLLSRGVGRGENFHGRTIVNLTWGTVPEARDARDWVEMYGGRYLDGAILDYPANMGPNALVLYSGDKAAFDEHAELLSTIARPRFEGTDPAAANALGMAGALFHNIALAGFYEAAAYAAQHGIAARTLFDLTAEIGFDLCARAFSDGLNRIESDDYHTDQSTIGIHFDTTLVQEAGFAEIGQAGTLNKAVRDILESATSAGEGGLAMSALYRRFLQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXB1</accession>
    <name>A0A231GXB1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putrescine importer PuuP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">puuP_1</name>
        <name evidence="6" type="ORF">B7C42_06626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41228">
        <property type="protein sequence ID" value="OXR41228"/>
        <property type="gene ID" value="B7C42_06626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="511" mass="54559" checksum="0EC820F50DF43FA0" modified="2017-10-25" version="1">MNNNKAARHSREITAEGDSTHFTRSMGVVETLSLGFTYMSPLGAIAALMPFGLMTAGPPSIWWLPIVAAGQLLVALVFGEVVSQYPITGGIYPWARRLWGKRYAWLAAWIYLCALIVTITSFTQFAVPYVGSLFGFVPSNAQGFLIVIGLLLLALAMNMGGTKTLGAVARIGFYAEIVGVIGYGLYLLAFQRHNSVSVFFHAMGTGGGAPYSSTFLLAALTGLFLFYGFEACGDVAEEVRRPGRTIPRAMILTVLCGLVSAGMAFLGFILAAPDLQSIVDGTITTDPVSAILDGTVGPWGTKVFLIVTLTAFLSCVLSLEAALSRLVFAFARDEMLPGSTYLSRLSKHGTPRVAMLFACAAPVALSVFVLIAPNSLPRFTAFAVCGIYICFHMVTFAALRMRFKGWRPAGDWRLGRAGFAVNVLALMWGVAAILILARPGSGDLAFLDRWIVVAGLVVVIVSGLGYMVVARPWGRSTAPSGDALEVAERMRAARLPATARSDDAPLSQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXD6</accession>
    <name>A0A231GXD6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450-terp</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41277">
        <property type="protein sequence ID" value="OXR41277"/>
        <property type="gene ID" value="B7C42_06675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="439" mass="48850" checksum="C0163768EB18C005" modified="2017-10-25" version="1">MTTVESDTGTVPDDIARTVVLPEGHADDAKVYEAYRWLRENQPLAQVRVEGFDPLWLVTKHADLMEIERQPEIFSAGGGPEKGTHNPILANQAGDEFTKKLTGGSLRILDALPYLDPPEHTTIKDVAFDWFRPANLKKWEDQIRENAKASVQRLISGSPVLDAVSEFSVFFPLRVIMTLFGVPEEDEPRMFALTQDLFGVADPDAIRDDVEALSPDAAAQQFAAAVADFYAYFDLLVEDRRANPRDDLATLIAVAKDETGEYFPKTFAYGWFVAIATAGHDTTASTLAGCLQQLAANPDVLARVKSDPSLIPHLVNESLRIVSPVKQFTRMALSDYELRGQKIKAGDRLMMLFQSGNRDAEVFDNPDTFDIDRRPNKHIAFGYGPHMCIGQHLAKLELKVMLEELLPRLAKVEVTGTPKMIQTNFVGGLRHLPVRLTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY89</accession>
    <name>A0A231GY89_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780909.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41559">
        <property type="protein sequence ID" value="OXR41559"/>
        <property type="gene ID" value="B7C42_06452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="265" mass="27903" checksum="40DE166509255D72" modified="2017-10-25" version="1">MIDIITLRGTGEPRNADGSPAGMLAAVTDLLSTDSFSFFEPDWPASVGPDPNLWGPSLDTSVRLGIAAGVEAIQQSPNVCALLSYSLGGICASRILEGVARGEYTNTDGSPLEIAFAVFIANPLRKAGDSVNNLCPPTTFGLHGQRGTWPAAVATREYANPGDIITASPADSPLRIIDVGISPFSFVEGARFGNASYLIFAQLLQFLMSNPVANLQRFATAVNGVIGYLTPYPDGQHVLYPAHDMPGTGVTWTTAAAEWITANFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYH8</accession>
    <name>A0A231GYH8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41649">
        <property type="protein sequence ID" value="OXR41649"/>
        <property type="gene ID" value="B7C42_06290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="437" mass="47407" checksum="C45EFF96ABEFE529" modified="2017-10-25" version="1">MSNIDERIRMAVEWLRGSQLPHLDGGAGWGWIPDVPPNPQNTAEVVCILHRAGCEIPRAAKVAMLVRATVVQRPIGDEWYFRTPIDVAWRIRALRCLGIAETDPDLAGSVRNLLDQQDSETGGWRMSGFLGPVSITATAAAVEALIGGGAFDGERHQAISRGIAYLVSSMYQEPRTLPMYAAAHIAAVLARPEIVRIGDKRAERACELAVKRLLTGLRRGEWDIETEIFRRDDLVDTWRHLTLHLAVGAVIAADSRTIFDPAVRAAIVALLDMQEMDALAIYRGGFRISDEGPVTSYATTQALEALLQVRPAINERVNPAKVYDEICRVDGAHRTDPQAIATLGGHRMLMNSTAGQAMLVLAASAGATVFALAVSFDTVFGTVGSRALVVWGTFLVAVGTYCGLATRFPRLPKRRVASAVFAAFTALVMPVVTYLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYV2</accession>
    <name>A0A231GYV2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_06136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41794">
        <property type="protein sequence ID" value="OXR41794"/>
        <property type="gene ID" value="B7C42_06136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="126" mass="13656" checksum="91912D640D647141" modified="2017-10-25" version="1">MSIDKLRLRRASYMVAAFGVLALVVTGPLDRLMLGVFICIGLGLGWLNAQLTLRSVTGITRSESPNKQALALSTAARLIIVTVLAIIVAFLTRPNGVGIFFGLALFQVILVLHTVVPEWRGLRQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZI7</accession>
    <name>A0A231GZI7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tgs1_2</name>
        <name evidence="13" type="ORF">B7C42_06007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42023">
        <property type="protein sequence ID" value="OXR42023"/>
        <property type="gene ID" value="B7C42_06007"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00343"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="11">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="12">
        <location>
            <begin position="219"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR42023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="359" mass="38269" checksum="A0A20E6C5B082DC1" modified="2017-10-25" version="1">MDRHLTHLRWPQPGTRRALFDIAADLLCRPFAPDLPLWQAYSVTGTGDTALVVVLHHVLADGLGSLAVLTALADEGNHAAVARFPRPAPSIRELAVDATLAKLHAIGSLAADLRRGCAGLRELTFGAPLLRPAERISLLRPTTHRRRVASTAVALNEVAATAHRFGGTVNDVVLAAVTGALLEILDARGERPHRLVMSIPVSGRRTTTVSDLGNDTGVRPLAVPAITDDAARLTAIVTATTAARGSSPRASSARPLGLAFRLIHRFGLFRLFIDHQRLVHSFETNLHGPATALHLVGHRIDALVPLVATPGNVGVTFAVLSYAGTLTVNTIADPDILPEQDTLTRALHATFTRLAHTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZN0</accession>
    <name>A0A231GZN0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42045">
        <property type="protein sequence ID" value="OXR42045"/>
        <property type="gene ID" value="B7C42_06029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="359" mass="38464" checksum="45C216541C30A518" modified="2017-10-25" version="1">MLIRRLARPLLASVFVVDGVDTLMHPEPRAQAATTLVSHGEQRLPDSVSAKLPSDPAKIVRINAVVRVGAGTLLALNRAPRLSSLALAVTVIPATVTEQDFWNESDAQQRAAKRTAFLKDVGLLGGLLIAAADTEGKPSLGWRGRRAARKAAAALPFTATTADTVRDRLQQQAVRGRELASVAADKGADLASVAQSRGAELASVAQSRGGELAEAAREHGTEWAELARDRGAEWAGAALDHRGEWAELAKRRGADLAEAAREHGSDWAEIAKRKSAELADTAGDHRGDWAELAKHRSTEWAEAAREHGGEWAEVAKQRGSIFARQARKRAEKAAEAARERAEKAADTARERLAEARNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZZ0</accession>
    <name>A0A231GZZ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42183">
        <property type="protein sequence ID" value="OXR42183"/>
        <property type="gene ID" value="B7C42_05782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="296" mass="31801" checksum="878BA02BDC465835" modified="2017-10-25" version="1">MAVGSEPALRYRVFRRAEVRVLLRTVRAAWSDELSDWAAALTYYSMLSLFPALLIAIVVLSIAGPAPADSLAGAAGRLGPGGGTSLISDSIHHLQSVKSLSGPMAVVGLLSAFWTVSTYLGAFIRAANDLYGVRESRSLWRTLPLRFALGLMLVVAVVVTVLGFAITPGLAEHAGNRIGMGSAGLLVWSIVKWPLLALLVSVALALLYWVAPNTEGQRWRWLTSGSVIAVGIWIAGSAGLALYAAHFDSLDRVYGSLTAAIVLLMWLWLTNFAILLGAVVDAQITRERTLREHPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0E1</accession>
    <name>A0A231H0E1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42231">
        <property type="protein sequence ID" value="OXR42231"/>
        <property type="gene ID" value="B7C42_05830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="38" mass="3827" checksum="A8E8F64938932025" modified="2017-10-25" version="1">MRKSEDTVEFLGSVAGILQMVIGTILANTGSGGSGSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0U2</accession>
    <name>A0A231H0U2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Resuscitation-promoting factor RpfB</fullName>
            <ecNumber evidence="5">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpfB</name>
        <name evidence="5" type="ORF">B7C42_05628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42427">
        <property type="protein sequence ID" value="OXR42427"/>
        <property type="gene ID" value="B7C42_05628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="4">
        <location>
            <begin position="210"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="380" mass="40283" checksum="F2A269F85EDE11B9" modified="2017-10-25" version="1">MPEFRISALQRINASRSPLLYAAIAAMLITLIIGASLAIVSRKTVTLVVDGQRTTVTTMAASVKGVLKAGGYKLAGKDSVSPSGDAGVSNGATITLNRARQIALTFDGKTKQVWTTAYTVADALTQLQLPGDVFVSPSRPTPLPLQGAALAVTSPRTVQLSDNGEPMSYVRLAAPTVGELLQVQGVPLTGEDTVQPTAVTPLHDGMKITVTRKRTEKVTEREPLDPTENVIEDTDLNMSRTVVENPGKAGVQDVTYAVSIVNGKEESREAVGHTVVVPAQPKTVRKGAKPGTEVPPVRDGAVWDALAKCESGGNWAINTGNGYFGGIQFDQSTWSRQGGLKYAERPDLATREEQIAIAEVTRARQGWGAWPACTSRLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H144</accession>
    <name>A0A231H144_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcoA</name>
        <name evidence="3" type="ORF">B7C42_05355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42578">
        <property type="protein sequence ID" value="OXR42578"/>
        <property type="gene ID" value="B7C42_05355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="37115" checksum="E559348B91B18E5D" modified="2017-10-25" version="1">MHVTEFFMPFDSEGANPAESEAEQVMWAWLERCDLVPSEPTRRRMRRTRPARMYALWCPYAGVDALGLLSRFTAWAFIVDDQFDIEIPDSARTLATITELEEVFEYGAQPRGVLAVAFAELWRELCAGRSSQWRHAVRTELSAWLWTYYTESIGRLTDRYPDLDDYRAHRRDSVALYVFLDISEIAEGVDLCAAARGLPALRAIREASVEHMGLFNDILSIDSDEASEYLYNSVLLAERQQGLDRKQAVEVVDRMLTECVRRMLTGIDALPAELDAAGLSGRERADILSTATCYTRYVRANFDYHYQAARYTSAPREALEHGAPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1C8</accession>
    <name>A0A231H1C8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase FadD15</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42617">
        <property type="protein sequence ID" value="OXR42617"/>
        <property type="gene ID" value="B7C42_05395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="610" mass="64075" checksum="F47ABE87EC2BB909" modified="2017-10-25" version="1">MTTAEIGYTHHTGATVRTVPEAFQQTATLRPNQVALRTVGGTQQITWADYARRVRAIAAGLAKLGVAHGDTVGIMLTNRPEFNLVDTAILHLGATPFSVYNTSSPEQIAHVFGNAENGVVVTEQAFLAPITASGAKLEHVIVVDGAAPEGGLTLEQVENDPAEDFDFDAAWQAVRPDDLATLIYTSGTTGPSKGVEITHANVVAQIVALTNGALVADIDARAVSYLPAAHVADRISGHCLTLFTGVTITCVPDPREIAAALPDARPTFFFGVPRVWQKIKAGVDAAIATESSPVKKALAQWAIGVGVATARARLAGGNGGPLLAVQHKLADALVLSKLRATLGLDELKVASSGAAAVPPETLEFLLGLGFTVSEVWGMSETTGVGTFTELDKPRPGSVGRAVDGVEIRLDSDGELLIRGGIVTHGYRKMPEKTSEAIDSDGWLHTGDIATIDGDGYVTIVDRKKELIITEAGKNISPTNIENSVKAASSLIGQIVAIGDSRPYIAALVVLDPDTAAVRAKALGIPDADLDTLAAHPQILEEVRGAIVAGNAKLSRVEQIKRFRILARAWEPGGVELTPTLKLKRSPIAAEYAADIAELYTDPVPEGVHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1U4</accession>
    <name>A0A231H1U4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036504454.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42820">
        <property type="protein sequence ID" value="OXR42820"/>
        <property type="gene ID" value="B7C42_05158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="7741" checksum="A02B6FA22F71250F" modified="2017-10-25" version="1">MEVKIGISDSPRELVIASSQTPEEVEALVSGALSGSGGVLTLEDEKGRKYLIQASKVAYVEIGTSTSGRVGFAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2A1</accession>
    <name>A0A231H2A1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778422.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42975">
        <property type="protein sequence ID" value="OXR42975"/>
        <property type="gene ID" value="B7C42_04861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="289" mass="32561" checksum="FCEB46921FB9E9EA" modified="2017-10-25" version="1">MAEPGEPLSLPKRQLGYYLRQAREETGMSLAEAAAHIGRSAPTLMRIEKGLTQKLSVPEIEAYCRLYEFDEEKIDAMKGLAQQADTKNWWHEYDDLIPADFDIYVGLETAAQEIATYQPELIPGLLQTPDYARALLRSALPDDPDEEIERRVQLKMRRQLLITRRVRPARLELIIHEAALWRVVGGAKVMSSQVRYLADIGTRANVDVRILPFTAGVPIGEAIGPFVMLRFGHATHNVVYAETYTGDLYLEKPASLRRYAGAYEVMQSAALDAARSRITLRQIAKEHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2N7</accession>
    <name>A0A231H2N7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="3">1.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acr1_5</name>
        <name evidence="3" type="ORF">B7C42_04990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43104">
        <property type="protein sequence ID" value="OXR43104"/>
        <property type="gene ID" value="B7C42_04990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="2">
        <location>
            <begin position="6"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="671" mass="72265" checksum="CC9BBFB26A8CC7A9" modified="2017-10-25" version="1">MATYIVTGGTGFLGRRVVEGLLSADTDAVVHVLVREASAAKLAELAARWNATDRVFPLVGDLTADGLGLADEPPAAQHVVHLGAVYDMTADEESAYAANVNGTRAVIALATGLDAMLHHVSSVAVAGDHRGKFFEDDFDLGQNLESPYHRTKFAAERLVRESTGLRWRVYRPAIVVGDSRTGEMDKIDGPYYFFPAIARLAALPGGLPLPLPDLGATNIVPVDYVAQAMVELIGRPGLNKRTFHLVNPRPQPFTEIYSALSRAAGAPGGVGPVPGSQTALATLNRLPGVTAARDFLLSQFGIPAEVAPHTSFASEFVSDSTRALLRRTDLEVPAFDTYAENLWRYWRAHLDPDRARRHGGGDRLRGRIVLITGASSGIGLATSHAVARRGATVLMVARGIDELEAAAAQVREQGGDAYSYSCDITDEKAVELLVKQVLADHHHVDYVVNNAGRSIRRSVLNSTDRMHDFERTMAVNYFGAVRLILALLPAMRERRFGHVVNISSIAVQTKQPRFAAYVASKSALDTFSEIAAVENADAGITFTSVRMPLVRTPMIAPTEMYRSLPVHSPEQAAAIVVRALEERPARIDTPIGTFAQVVDTVMPSVKKAILHQGFRRTGESAAARHGRTASSDTAETGGRSPLLALAPVVQPLMGLPTPAARIINRLPGLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2R1</accession>
    <name>A0A231H2R1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43132">
        <property type="protein sequence ID" value="OXR43132"/>
        <property type="gene ID" value="B7C42_04554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="469" mass="49262" checksum="3CCD2C58069BB40E" modified="2017-10-25" version="1">MILSRFVRIQLLIFAVVTVVALLVMGLVYMRLPSLVGVGRYTVRVQLATSAGLYDSANVTYRGKTVGIVTGVVPTGAGAEATLSVDSSVRIPVSAIANVHSRSAIGELYLDFVPTSQSGPYLENGDVVPATRTTVPQDIAPLIDTLDTSLTSIPKDKLSTVIDETQRAFGGSGDALQRLLEGTDRVLDQAHTDTDAVTTLIDDSAPFLDSQQVSSPAIREWVAHLSNSVRQAQASDQQIRDVLKTGPGAAREASRLFGQLHLTAPLLAANLTSLGQVAVTYNPSIEQLLVLLPASVSALKTINLPDSGGTNRAFLDFKLNLNAPPPCTTGFLPPEQRRDGSSTDAPVRTPAPIYCAIPQDAPNAVRGARNLPCMDNPGKRAPTVEECDSDRPYVAQGTNPWRENPTPTADNPQAPAAAATPTPRVGTAAYDPATGGYVGSDGTVHTQPGLVAGTGQIAPTLQTLLTGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2U9</accession>
    <name>A0A231H2U9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43181">
        <property type="protein sequence ID" value="OXR43181"/>
        <property type="gene ID" value="B7C42_04603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="125" mass="13544" checksum="0EAAE019A40FC0EF" modified="2017-10-25" version="1">MARGILYVETRPSAPQRTAEYHSWYDETHLREVVAMKGFVSGRRLEPVADDGPFVALYEIEADDLQAVVDRLLAAAVGGALHMSDALCMDPAPVVRLLRTITVQESEPEPGPGRSALADSGTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H393</accession>
    <name>A0A231H393_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Caffeyl-CoA reductase-Etf complex subunit CarC</fullName>
            <ecNumber evidence="8">1.3.1.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">carC_9</name>
        <name evidence="8" type="ORF">B7C42_04710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.108" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43288">
        <property type="protein sequence ID" value="OXR43288"/>
        <property type="gene ID" value="B7C42_04710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="207"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="349"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="458"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="564"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR43288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="713" mass="75093" checksum="68C8C22F07FBCF41" modified="2017-10-25" version="1">MPLALTDDHLAIAEAVRSFLTEQQAHALARRFLDDPETDATELWKPLAGLGWLGLHLPTEFGGDAYGLPELAIVAEELGAVVAPVPFVPTVVVSSLLAESGTEAAKKALLPGFADGSEVAGLGLHGDVSADGSGALSGGAGHVVGAGAATLLAVRVGGDIALIRSDADGVDAQLVDALDSSLQIRRVALRGVTPEAVLSGTAATAARTARILGAAEAAGGARATLEQALAYAKVREQFGRAIGSFQAIKHHLADMLAGSELAVATAWDAARAGAHGEQGVLTANVAGAIAYDEYVRNAEKSLQIHGGIGFTWEHDCHLYLRRAQSIRALFGAVDVALDAVYTDAVAGVRREYAVDLPPEADEFRSAAAAFVTELNTAPESERRRMLVDSGYLMPHWRKPFGREAGPIEQLVIDEEFAEVDMPNLGIGAWVTLTLSQHGTPEQIERWIRASLLGELVWCQLFSEPGAGSDAAAVSTRGVRVDGGWRVTGQKVWTSNAQNCNRGLATIRTDRNAPKHKGITAVVIDLGAPGVQVRPLREITGDAVFNEVFFDDVFVPDSDVVGEVNNGWTVARATLGNERVSIGGMSHGRTPFDLIDLVHIAGDELAAKREVAGLLAMEQALQVLNLRHVARAVTGAAPGPEGSVTKMLSAEHLQHTAEAGMRLAGEAAVVGQLPEVSRDYLFGRAHTIAGGTSEINRNVIAERLLGLPREQIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Q0</accession>
    <name>A0A231H3Q0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase 2</fullName>
            <ecNumber evidence="3">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB_3</name>
        <name evidence="3" type="ORF">B7C42_04341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779294.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43474">
        <property type="protein sequence ID" value="OXR43474"/>
        <property type="gene ID" value="B7C42_04341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="31287" checksum="365DF8F8B598E050" modified="2017-10-25" version="1">MATIEEALEIERLERDIFRGAITKSQLARTFGGQVAGQALVSAVRTVEPRFEVHSLHGYFLRPGNPAEQTVYLVERIREGRSFCTRRVTGVQDGEAIFTMSASFHVGDEGPEHQDVMPEVPLPQDIPDERAAMSPERLWLMREWEHWDIRLVPQEQVVRRDGLASQQQVWFRYRHPLPDDPLFHVCTLAYMSDMTLLGSSKVTHRDEPTQDASLDHAMWFLRPFRADEWLLYDQNSPSAGYGRALTSGRIFNQRGQFVAQVVQEGLIRTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4N6</accession>
    <name>A0A231H4N6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent Clp protease ATP-binding subunit ClpC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">clpC1_3</name>
        <name evidence="4" type="ORF">B7C42_04059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43824">
        <property type="protein sequence ID" value="OXR43824"/>
        <property type="gene ID" value="B7C42_04059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="21188" checksum="8AFF1F205DEF013F" modified="2017-10-25" version="1">MFERFAKAARSAVVDAQEEARELRSPSIDVEHLLLGLATCADVQLRKVLEDNGITAEAIRSSLPGRPRAEEPLGEEDAAALKSIGIDLDAVRDSVQASFGEGAFDEAVPVPDKGRGRFRFGGGMTFGHIPFTREAKKTLELSLREAISRGDDRIEAGHVLLGILRAPNPTTRELLGGNEGMERVRGAVQEMLDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4S6</accession>
    <name>A0A231H4S6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rplJ</name>
        <name evidence="9" type="ORF">B7C42_04103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781107.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43864">
        <property type="protein sequence ID" value="OXR43864"/>
        <property type="gene ID" value="B7C42_04103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="18909" checksum="9F193A7AFA994100" modified="2017-10-25" version="1">MAKPEKVTAVAEITEQFKSATATVITEYRGLSVGNLTQLRRALGSNATYSVAKNTLVKRAAAEAGVEGLDDLFVGPTAITFITGEPVDAAKALKTFAKDNKALVIKGGYMDGAALSVSEVERIADLESREVLLAKLAGAMKGNLTKAAGLFAAPAGQVARLFAALEDKQRAAGGAEAAPAADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4V2</accession>
    <name>A0A231H4V2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme chloroperoxidase</fullName>
            <ecNumber evidence="2">1.11.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cpo_3</name>
        <name evidence="2" type="ORF">B7C42_03981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.10" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43746">
        <property type="protein sequence ID" value="OXR43746"/>
        <property type="gene ID" value="B7C42_03981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016691">
        <property type="term" value="F:chloride peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="338" mass="36273" checksum="DEDCA542A0816B98" modified="2017-10-25" version="1">MLVNLPENVADLRTGIGALTGGYRAKMRSRTYRTAELNCAPDAEVLSVTTTDGARLRVHAYGPVDGDVIVFVHGWSCCLEYWNPQINAFARDHRVIAFDQRGHGASTLGTGRFDAEQLADDLCAVLDAAVPAGRKAVLVGHSMGGITIQAWAKFHPEQVAQRASAALLLTTTAGDIAAETRVLPIFNDIVPAPNWLGRALFGQPVPFPAGAPVRGIFKARIMNRYATADQVDFGLSIVRSCRPLVRAKYALALIELEIHGAAANLCVPTSVMAGAYDNLLPESMSRKIADELAAAGNLDRYSVLATGHLANIEASAEFNAELRRLIEVTRFGRRAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4X1</accession>
    <name>A0A231H4X1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030516176.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43766">
        <property type="protein sequence ID" value="OXR43766"/>
        <property type="gene ID" value="B7C42_04001"/>
    </dbReference>
    <dbReference type="GeneID" id="66724335"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13733" checksum="842B7165C64EDF49" modified="2017-10-25" version="1">MTVANALAITSHVDTAKLRPAELARQLVQHLGPTLVALIAGVRDRKLPHKWSHAEGPTPRDAALARLQVAHRCWIILATAEDSDVARSWFIGANPRLGEESPALAIRADRFRETIAAAVAFVDGSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H503</accession>
    <name>A0A231H503_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43920">
        <property type="protein sequence ID" value="OXR43920"/>
        <property type="gene ID" value="B7C42_04159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="741" mass="76197" checksum="89E375E1C816866A" modified="2017-10-25" version="1">MGCMTDPANARFGEPHTAREGHRLTRSEEEPGQQGGSGGPAHGGAEKFGLRWDSAEFGDSGSGESVFGPPPGASPTDVPSYSPDYLSGSAVPTPPAAPPLPVRDTSARTAIPPLPTREPALPTREPAQRSMFASPFDADYERGAGQDHPAADTDESAPTSSFAVSAAETPPVDPRSGVLGSSTPPGGIERAATEKARWADELDAGSQDPEDTVRRIAESLGIDPGRQSRSRSAEPKAAKSSPAEPPSAEPPEPRRADAAESDASSTASDPAPPKLPTRLPTPAHGIARAESADAGTESAAASASAEARPEATRRPIPRAARRARDNEQPAANTTASRLSGEITASPAAEPAGEGQHGTARPASTEPPATTATPADAEARGTTTNDGASATRRATSPGGDADPAPALPAATPPAGQPGDDARRSATATESVTDGDHTPPGTRADSARIAAEHPVAEANPTTNATTEEDEKSPAAARLPHRHSNEPARTDHAETTGPAHSGPADGTDRLDSEDPQSWQNTDTLPAIRGRAESTDATSRPLPTRNGATVGLRSASASTLLDQSDTDILRRRAAQAPAAEYVPTSRHRSPAEETGTDDQPATESAEAVATSHDSANDAAHAEPAAGTGGRRNRRATDDHHSGDTPTDIASRTGVPPTSRRAARRRAETTGEPPAIDVGLVMQLLLASHTLENVARNAEAGDVDLNGLITAAHRTRTAAVELVTTWFGGADQMREFAEALLAATEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H529</accession>
    <name>A0A231H529_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor SdpR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdpR_2</name>
        <name evidence="2" type="ORF">B7C42_04210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776408.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43971">
        <property type="protein sequence ID" value="OXR43971"/>
        <property type="gene ID" value="B7C42_04210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12441" checksum="098BC13C95633D3A" modified="2017-10-25" version="1">MTEFGPEEEAGVFRALADSTRRQILEDLRSGELTAGDIAAKFPISGPSISRHLGVLKAAGLVRERRVANRIYYSLVEERLALCVGRFLSAICPEQVVVRQRRLRTTKNRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H571</accession>
    <name>A0A231H571_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43958">
        <property type="protein sequence ID" value="OXR43958"/>
        <property type="gene ID" value="B7C42_04197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="15182" checksum="17B80B79646157A9" modified="2017-10-25" version="1">MPSITDPEVREFLAAGTRTGKLALVASDGRPIVNPVWFILDGDDLVFNTGKTTAKGKALARDPRVALCVDLDEPPYAYFQVQGVATLSEDPAELLRTATAIAARYMGPDRAEEFGRRNAVPGELVVRVRPDKILGGLNMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H577</accession>
    <name>A0A231H577_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44005">
        <property type="protein sequence ID" value="OXR44005"/>
        <property type="gene ID" value="B7C42_03561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="15113" checksum="D5C778E05251B207" modified="2017-10-25" version="1">MNQEPDRPADVREPGNPPTARLSARENAYPPVEMPPYPPSAGDLVEYHPHHPPAQPMPYPPSKQLDPLALGLPYTSVPQGVSQPVPPMLMVQQFHPGMGQVVVKRSFPHGLHLVLTLITCGLWAPIWLIHYLLADNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5A0</accession>
    <name>A0A231H5A0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043262.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43906">
        <property type="protein sequence ID" value="OXR43906"/>
        <property type="gene ID" value="B7C42_04145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="10911" checksum="37515D53DE09F481" modified="2017-10-25" version="1">MAGPNDPPANAMKIDPAALQSFAKTLRDESDAIGKLDSGLAGAAGALPGTGWDAACTGAKDSVENALKRIGSRVTHIADTVEQAGKVIIDTDQQLRDDLNKIGIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5K7</accession>
    <name>A0A231H5K7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44141">
        <property type="protein sequence ID" value="OXR44141"/>
        <property type="gene ID" value="B7C42_03700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="8206" checksum="DB3812F1AFDF65EA" modified="2017-10-25" version="1">MSLDRVGSVGSVGSVGSVGSVGSVGSVGSVGRMYTQVDGGYTPHLSEATGVSAACGASIPGMTWGVSREAETDHGCGLVLVVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H621</accession>
    <name>A0A231H621_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YtcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytcD_8</name>
        <name evidence="2" type="ORF">B7C42_03846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777631.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44285">
        <property type="protein sequence ID" value="OXR44285"/>
        <property type="gene ID" value="B7C42_03846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15718" checksum="F330516E5D0EB5E4" modified="2017-10-25" version="1">MTAKVFEGARSSSEYNAFLAACPSRQLLDRISDKWVVLILCALSGDAGAASDRPGAPRAMRYSELSRLLVGVSQKMLTQTLRALERDGLLTRTVTPTVPVTVTYELTQLGLSLHHLTRGLRSWAQDHMGEVLAHRESHDARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H694</accession>
    <name>A0A231H694_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44381">
        <property type="protein sequence ID" value="OXR44381"/>
        <property type="gene ID" value="B7C42_03170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046134">
        <property type="entry name" value="DUF6131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19626">
        <property type="entry name" value="DUF6131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5241" checksum="7F25412536C2047F" modified="2017-10-25" version="1">MITLGVVLLVLGFLLGIPILWTLGIIALVVGAALALLGALGRPVAGRAHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6H4</accession>
    <name>A0A231H6H4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cysS</name>
        <name evidence="13" type="ORF">B7C42_03228</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775743.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44439">
        <property type="protein sequence ID" value="OXR44439"/>
        <property type="gene ID" value="B7C42_03228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="338"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR44439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="461" mass="50726" checksum="D42F6AEB5524C53E" modified="2017-10-25" version="1">MTLRLFDTATRTLRDFTPLVPGRASVYLCGATVQGEPHIGHVRSGVAFDVLRRWLTANGYDVAFVRNVTDIEDKILTKAAAAGRPWWEWAATHERAFDRAYEALGVLPPSVEPRATGHITQMVEMMQRLIDRGHAYASSGNVYFDVRSYPEYGALSGHKLEDVQQGESAGEGKRDPRDFTLWKAAKPGEPTWPSPWGPGRPGWHLECSAMAEFYLGPEFDIHCGGMDLVFPHHENEIAQSRAAGDGFAQYWLHNGWVTLGGEKMSKSLGNTLSVPNILTQVRPVELRFYLGSAHYASMLEYSEQALRDAAQTYQRLEAFVQRTVERVGEVAVGKWTDAFAEALDDNLAIPKALAEIHRVVHEGNRALEAGAGESAREAAGQVRAMLGILGVDPLDPHWAGPKDTSAAESALDILVRAELERRQQARSEKDWATADAVRDRLVAAGIEVVDTAGGSDWSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6R5</accession>
    <name>A0A231H6R5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="6">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acdA_1</name>
        <name evidence="6" type="ORF">B7C42_03328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44539">
        <property type="protein sequence ID" value="OXR44539"/>
        <property type="gene ID" value="B7C42_03328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="214"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="38865" checksum="E1EE7251CC5C146D" modified="2017-10-25" version="1">MDFTLTEGQQDLARLTGEVCAKLVTADRLRELDKAEVRFDDQLWRSLAETGVLAAALPESVGGSGLGALEQTAVLREIGKSAAPVPYLWSVVLGAGALARWGDQAQRELAAKAGAGETILSVALSEERNWEPAKPTTTATEDGGWKLAGAKTVVPFAAQAARILVPATVSGKAAVFLVDPADARVTPQQVVDRSPQAEVEFDSTPAELVGTVDDGAEILGWLLNHGWLGLAAQQLGTLERAVDLVAEYGREREQFNRKIGSFQAVAQRLADGYIDLQGLRLAVTQAAWRVDEGLPAEAEIHTAKFWAAEAGHRIAHTAVHVHGGVGIDRDHIVQCYFTAAKHNEFALGGATDHLRALGTLLAEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6U7</accession>
    <name>A0A231H6U7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051041837.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44467">
        <property type="protein sequence ID" value="OXR44467"/>
        <property type="gene ID" value="B7C42_03256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="14988" checksum="089E4BB0B5908E04" modified="2017-10-25" version="1">MTKFLAVLSGLLLTTAVGIVLPWAAIPVFVAVVVGWRFRTVAVLAVLVALGALAWADTGALAAAGTGLVATTYLLNTATLHAPAGVVPTTLPSVFGALAFAAAAVLATLIPGRLAWLPLLAPVLVIVLYAAIVQGVVGREDAPDTAEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7F4</accession>
    <name>A0A231H7F4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776332.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44722">
        <property type="protein sequence ID" value="OXR44722"/>
        <property type="gene ID" value="B7C42_03516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="11623" checksum="9559276DC86252B4" modified="2017-10-25" version="1">MSTLGIRTVLHPVTDLAAAKAVYAALLGVPATAESAYYVGFEVGDTHVGLVPGGGPQGMTAPVTYWAVPDLEAKLAELTAAGAVVGEPIRDVGAGRRVATVIDPDGNVLGVLQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7H9</accession>
    <name>A0A231H7H9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine catabolism regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pucR_1</name>
        <name evidence="4" type="ORF">B7C42_02839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44884">
        <property type="protein sequence ID" value="OXR44884"/>
        <property type="gene ID" value="B7C42_02839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="176"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="402" mass="43518" checksum="6DE1549703EC89E6" modified="2017-10-25" version="1">MAVVAPAEIPEQVPDSAELARACGSDIAELTARLMAAVFTDNPEWTDYSAVSRTDLQEGCRRFLTRVLELLAAKGAGAERDDVAAAIGRQRAAQGVPLEAMQRTFRLGGRIVWEALMDRAGDMSPADFREIGTAMWAVVDGMSSALVTSYRGAELDRVRRDERRRHALIEDVLSGRGRDAAFAAYAARELDLPAGGDYLVVVARGEPQPLRLGTESALAAMGIRSVRHDRGDHTVGIVALEQHSPQQVAELLGPLVLGRAGLSPAVDGLAEIDVAHALATLALDTAPRDREATLTLLDDRYPEALLVRAPDLAQRLVQRCLGPILALPARERDILLRTLTVWLAENCSAAHAAPLLHCHRNTVINRLQRAATLLGRPLEGRRHQFELTLALTARDLLDHSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7K5</accession>
    <name>A0A231H7K5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetoin dehydrogenase operon transcriptional activator AcoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acoR_2</name>
        <name evidence="2" type="ORF">B7C42_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44861">
        <property type="protein sequence ID" value="OXR44861"/>
        <property type="gene ID" value="B7C42_02815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="103"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="422" mass="45557" checksum="5F04BA326591B623" modified="2017-10-25" version="1">MGSFEAITPGTDLPRYARDLVRMHDAVIGGGRAPLRPRTVVARSWSRVLAAGLAPDRTNTRAILPFDEIEQRRRTSPLQEVIGDLSRILTGVADSSQMMMVVADADGIVLWRSGAARVRGRADELGFREGATWTETTVGTNAIGTALAEAVPVQLFSGEHFEQSQHPWYCTAAPLHDPRTGDLLGVVDVSGPALTLHPTVTALVSAAVEIAQGQLLHRQYERLQRLRDTAMPALSALPGPALVIDRNGWVAHATGVAPARRIAVPNSERAVQVPGLGLCIAEPLAEGWLLRPMTGDTRIRMTLDLSGAPVVRSTGGESDWHTPLSQRHAEILLLLHRHGRRGISVTELSTAIHGDPDHAVAIRAELSRLRRILGSVIENRPYRLSAAVEFTVELGDTLTGDAYLRGAGFSPENDAFRGRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7Y1</accession>
    <name>A0A231H7Y1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44981">
        <property type="protein sequence ID" value="OXR44981"/>
        <property type="gene ID" value="B7C42_02938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17380" checksum="0F5839B54492FEB2" modified="2017-10-25" version="1">MGASARRIKKVLDRLPVPDPWDRTRFVAAVAAARGRPITLIPMAMHDVIDTPCGLWLVREDDDVIIHEDATSEYHIDQIVCHEIGHMVLGHDRGTSGGGCDSTLGAVLPDIDPATVRAVLGRSGYGSGPEREAELFASLVMVSATAGRRGQSLRNVLFEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H890</accession>
    <name>A0A231H890_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACP_syn_III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45069">
        <property type="protein sequence ID" value="OXR45069"/>
        <property type="gene ID" value="B7C42_03026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="1">
        <location>
            <begin position="84"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="30834" checksum="D083BD40D355E199" modified="2017-10-25" version="1">MGVAITSTGISREGDTFSIVEHSGRAARRSLERAGVAPEQVGVLINAGIFRDSNTVEPAVSALIQKEAGIGLDYRFGDPRSFSFDLMNGATGVLNAVQVAQSILETAGSGHVLIVSGDTHPSLTRSAADDEFPYATAGAALLLEHTDEPVGFGRVHTVAGSGSPAVQSYVDVTTMGTAGRGLMTVEREPGFEDRLLEIAAEAGRRALDADGIDTAATVLIASTPTPKFPRLLADTLGIGAVRTPDLSAGDPHTASLPLAYHRAVEEDSLLGFDTVLFVAAGAGPSAAAAVYRLPVAAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8P7</accession>
    <name>A0A231H8P7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase subunit beta</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bkdB</name>
        <name evidence="2" type="ORF">B7C42_02353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776782.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45228">
        <property type="protein sequence ID" value="OXR45228"/>
        <property type="gene ID" value="B7C42_02353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="35843" checksum="77F2805F9EEEC43E" modified="2017-10-25" version="1">MITTFANALNTGMRRALEDDPKVVLMGEDIGRLGGVFRVTDTLQKDFGNNRVIDTPLAESGIIGTAFGMALRGFRPVCEIQFDGFVYPAFDQIVSQVAKIHYRTQGKVRAPITIRIPFGGGIGSVEHHSESPEAYFAHTAGLRVVSPSTPEDAYRLLRQAISCDDPVVFFEPKRRYWDKADLDFTALDADPLPLDRARIRRSGRDATIVAYGGMVATALTAAEIAAGEGHSLEVIDLRSLSPIDFDTIEESVRRTGRLIVTHEAPVFAGLGAEIAARIAERCFYYLEAPVLRVGGFDIPYPPAKLERHHMPDPDRILDAVDRTFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8T5</accession>
    <name>A0A231H8T5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator AcrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acrR_3</name>
        <name evidence="5" type="ORF">B7C42_02337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45212">
        <property type="protein sequence ID" value="OXR45212"/>
        <property type="gene ID" value="B7C42_02337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="22332" checksum="CF1A5679675C06A1" modified="2017-10-25" version="1">MTKAPATRGRIDKRQAILDVAFDVFARRGYGRACVQEIADEAGVAKPTVYNHLSDKETLFRSTVEAAADQVGAQCLAAVETLRAVDGDPGPALTATARELVHICAGPRSHALRALAYAELGTFPDLVLTVQERTSLRLAQTLADRFARLALSGVLRRSDPELAAEHFLALLTGPLEARSRLGTRAVEPAELDEIADAAADAFLRAYGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8U0</accession>
    <name>A0A231H8U0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="5">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_03103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45146">
        <property type="protein sequence ID" value="OXR45146"/>
        <property type="gene ID" value="B7C42_03103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="522" mass="57844" checksum="3EE64D38E265D979" modified="2017-10-25" version="1">MFGKALRRGAGQSLSVAIVGSGFGGLAAAIELQRNGFTDFTVFERADSVGGVWRDNHYPGAACDVPSVIYSFSYALKPDWSALFGKQAEIQQYLERVARETGVLSHIRFGTEVTATIFDETTGKWRVELGTGSSVMVDAVVMATGQLSRPKMPQVEGLASFKGPAFHSAEWDHSVDLTGKKVIVVGSGASAIQIVPAIADRVAELSVVQRSPNWVIRKSKRVHGSVARAILERSAVMRKLHHDMMFLAYECRWPLVSRKAKPVRLASEWWYKRIIRKTLKDPEAVRAATPDYTMLCNRLLLSNEWYPTLAKKHVRLFGSGVAEVVEDGIITADGRKVDGDVIVWCTGFKASEFLSPIKIVGRGGADLHKLWQHGAEAYLGLSVSGFPNMFMMFGPNTNSITNSIVFLLERQAEYVRMALEQVVRAGGGWFDLLPAEQARFQQWLQGKLGETVFTDTCPGWYTNAEGKVTAMWPLSHITYARMTRRFDASKYEYGTERGKRGRTATQAATAPPSDEDYVVDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8U2</accession>
    <name>A0A231H8U2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45107">
        <property type="protein sequence ID" value="OXR45107"/>
        <property type="gene ID" value="B7C42_03064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="49023" checksum="AC68F4C422E41866" modified="2017-10-25" version="1">MSAVTFGSPDIRGHVQRLSAGITDTHWLRVAAETSAACITAAVAGLAMMMPISQSWLSPGSALQVDLLIFNMPLALTAGALIAVIAVSVAAAIGNSRLAWCTVFCASAAMLVNHTLLVRLETRTLSTLNYVDSMLAGVILGCLAAAVWHRRAPAGGYLFGALASILFADLTQAPDFASAVPGEGILRGAPPVWLILVALGLMLFTAVLFRQERQPEPDNSAVVPLKPVVSAVVIVSATLATSVWMARGGALVSILVGGAILLLATMVAALLLPERDGLLIVVMVAFASAGSALLTVPRPSWSTLLVVAAAGAGLYAGWRIRLPMPAVAGSVVLAIAAAVSAALVDVPTAAVTVPSCIALAAMAGYALGCAIGPRATSAVVGIVILFVPSAGVALQGRDLGRLEYSHTWFRSAEAAVTAVPGIVAAGIGIGCAAIVLLIGRLRPEDALGRRRAGGVVGPKPNPAQARRNSLTTSKSTPSASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8U5</accession>
    <name>A0A231H8U5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="1">MTA phosphorylase</shortName>
            <shortName evidence="1">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnP_1</name>
        <name evidence="1" type="synonym">mtnP</name>
        <name evidence="3" type="ORF">B7C42_02568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45443">
        <property type="protein sequence ID" value="OXR45443"/>
        <property type="gene ID" value="B7C42_02568"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="30640" checksum="68B806FA9C0BF00A" modified="2017-10-25" version="1">MWGEAAGAAAAAYARIAGMSSDPRPALAIIGGSGFYDFFGDDATTLEVETPYGVPSAPITVGEVEGRQVAFLPRHGRKHEYSPHTVPYQANMWALRSIGVRRIFAPCAVGSLRADWGPGTVAVPDQLVDRTSGRAQTYFDNGGIHVSFADPYCDDLRSIATRAAVPELPMQSAATMVVVQGPRFSTRAESRWFAGQGWELVNMTGYPEAVLARELEMCYAAIALVTDLDAGLEAGEGVSAAAVFAEFERNLVPFKTLVRRAVAGVEGTETCEHCTVHAGVALPFELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9I3</accession>
    <name>A0A231H9I3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">map-1</name>
        <name evidence="2" type="synonym">map</name>
        <name evidence="5" type="ORF">B7C42_02616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498219.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45491">
        <property type="protein sequence ID" value="OXR45491"/>
        <property type="gene ID" value="B7C42_02616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="27955" checksum="EE91CB23023AE777" modified="2017-10-25" version="1">MVFGLKQKKVVPFRTAGELDAMAAAGAIVGRALVAVRAAAKPGVSTLELDEVAEQTIREAGAVPSFKGYHGFPGSICSSVNDRVVHGIPSKDEVLAEGDLVSIDCGAILEGWHGDSAWTFGIGEVIEADRLLSEATRLSMDAGIAAMLPGNRLTDVSHAIELGTRAAEKEHGRAYGIVDGYGGHGIGRQMHMDPFLANEGAPGRGPKLVVGSVLAIEPMLTLGTTETTVLEDDWTVVTTDGSRAAHWEHTVAVTEDGPRILTVRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9P9</accession>
    <name>A0A231H9P9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ESX-3 secretion system protein EccB3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">eccB3_2</name>
        <name evidence="12" type="ORF">B7C42_02591</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45466">
        <property type="protein sequence ID" value="OXR45466"/>
        <property type="gene ID" value="B7C42_02591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXR45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="496" mass="51177" checksum="CD691B2E23751495" modified="2017-10-25" version="1">MPAQLTTRAQVNGYRFLLKRYEHALVRRDVRMLHDPMRTQFRSLVIGAVLGLLGVAGAAILAFLHPQGSVGDSKIVMGKDSGALYVLVDGTLHPVLNLASARLITGVAASPASVKDGKLTQPRGPLLGIPGAPGALSGSGDPRRSTWTMCDNLLPPATGPLTTVIAGPLDNPAGGTHAVPVRADQALLATHGGKTFLVYDGKRAEIDPADSVLIRSLGLRDQRPRPIGGALLDATEPVPPLTVPEIGGHGAPGPGKLSDVPVGGVIRVHGVDADELYVVLADGLQRVTPFAAGLIRDANSQGMNEISTVPPDRIVGIPVLHRLPIDDFPQQVPAVLAPDADPVACVSWTRAADDARATVTLLAGRALPLPADAEPVVPATADGAGDRIDGVYLRPGTGEFVRSVGAEPGAVSNGPLFYVGDNGIRYGIPDADTAKVLGMPKTPKPAPKPIVEALSAGPALTRQDALMSHDSLPQCPDAGPSATACARPIPPPGKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9X2</accession>
    <name>A0A231H9X2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45763">
        <property type="protein sequence ID" value="OXR45763"/>
        <property type="gene ID" value="B7C42_02055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="169"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="308" mass="32117" checksum="691579F410A90126" modified="2017-10-25" version="1">MTPDPASDIRHSAAAAVVVGVDGSGHADLAVDWAAGMAAQRGRELRIVHALDLNRIQLGIGSLDSPAAAMLSAARERGAALVERSAQRVQAVLPGLRISTEVVDRDPARALVNASVSAYVVVLAAHGTHRLAGHFGSTVSAVAAHATGPVLVVRTDPREEDRVHTEGPVVLGVDGGPVSEAAIGAAFEEAAERGAELVAVHVCHDVYYGQFADDPHILYSAREVEVRERAVLAERLAGWQEKYPDVPVTRQVSLADPGAVLLKSSSSAQLLVVGSRGRGAVLGALLGSTSHALVQHAWCPVMVVHPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA39</accession>
    <name>A0A231HA39_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE12</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_02012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782717.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45720">
        <property type="protein sequence ID" value="OXR45720"/>
        <property type="gene ID" value="B7C42_02012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="392" mass="43515" checksum="7EB58F1AE99ECF87" modified="2017-10-25" version="1">MSAGMTFEPTEDQQVIRSAVAELCRKFDDRYWMRKDQDHEFPTEFYQAIAAGGWLGITIPEEYGGHGLGLTEATILAEEVARSGGGMNAATAIHLSIFGMQPVVRYGSEELKRRTLPRVAAGDLHVCFGVTEPGAGLDTSRITTFARRDGDHYIVNGRKVWISKALESEKILLLTRTTGYDEVTRKTDGMTLFLTDIDRAHIDIRPITKMGRNAVSSNEVFIDDLRIPVEDRVGEEGEGFRYLLDGLNPERMLIAAEALGIGRVALDRAVKYAGERVVFDRPIGMNQGIQFPLADSLAHLDAAELVLRKATWLYDNGKPCGREANTAKYLCADAGFTAADRAMQTHGGMGYAEEYHVARYFREARVMRIAPVSQEMILNYLGSHTLGLPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAA6</accession>
    <name>A0A231HAA6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_9</name>
        <name evidence="1" type="ORF">B7C42_02092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45800">
        <property type="protein sequence ID" value="OXR45800"/>
        <property type="gene ID" value="B7C42_02092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="259" mass="26920" checksum="AA448161B318CB83" modified="2017-10-25" version="1">MTEQHGSGGADIFELKGRVAIVTGASSGLGAAVARTLAGLGARVAVVARRRDRLDELAAEIDGLAVTADLSELDRIGVIAEAAAAGLGPPEILVNAAGTMFTEERAESEPLPAIRSTLELNLAAPLLLSQAVFEHMRAAGRGSIVNISSISGRVGIPGIPQASYAASKVGLSGLTAELAVQWARHSIRVNTVAPGFFRSEITAPLYDNERPREYLRRNTPLPRHGTPEDVVGAVAWLAGDAAGYVTGQTIVVDGGWTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAG9</accession>
    <name>A0A231HAG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclopentanol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cpnA</name>
        <name evidence="1" type="ORF">B7C42_02104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.163" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45812">
        <property type="protein sequence ID" value="OXR45812"/>
        <property type="gene ID" value="B7C42_02104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055041">
        <property type="term" value="F:cyclopentanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="277" mass="29099" checksum="32FE4DD9933D3325" modified="2017-10-25" version="1">MTTVGLVTGAGRGMGSECARALADRVDVLVLADRDEAGATAAAEQLRSEGARAEAFVVDVADRDRVSELATYLAEEGELRAVAHAAGISPTMADWRRIFVVDLIGTAHLLDAVRPLAVAGTAAVVFASMAPLLDPNPPDPAALAVLDDPLHEDFLDRIRDAVGPALEHPGIAYGWAKRGVQRLVWREAVRLGPAGARICSVSPGIIDTPQGRQEAAEHATMRRLVERTPLRREGRPAEVAAVVAFALSDAASFLNGTDLVVDGGVTAALRAGPDSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAJ0</accession>
    <name>A0A231HAJ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative NAD(P)H nitroreductase acg</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acg_1</name>
        <name evidence="1" type="ORF">B7C42_02039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45747">
        <property type="protein sequence ID" value="OXR45747"/>
        <property type="gene ID" value="B7C42_02039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="356" mass="39633" checksum="7DC48062471D9316" modified="2017-10-25" version="1">MTIGPTTRDQCPYSHRLAVVRLDTMTTAKHSTIVDRPDDRTVAAVVELAQRAPSVHNTQPWRWIFDRHQLLLYTDPDRVLAGADPHGREQVISCGTVLHHARTAFAARDWHTDIVRMPDPQEPGLMAVLEFRPWGDPPDGIPHRAAAITRRYTDRLPMDAPRHWEQVAPRLRALVTPHDLDFDEFAGDIRARVAAISRAAAAARRDDWMYQDELHWWAGHVEGSEGVPASGLISDAELARVDVARAFPSAPHSQRRAGHLDHARLVAISSPEDARPYWLRTGEALSAVLLECTATGLGTCPVTHLTEVPAGRRSLAALLPHHHFPQVLVRIGNSPADEPIPPSTPRRDIDEVLTFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAP6</accession>
    <name>A0A231HAP6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46023">
        <property type="protein sequence ID" value="OXR46023"/>
        <property type="gene ID" value="B7C42_00986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511458" evidence="2">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="86" mass="8728" checksum="1E23A8490B1407DD" modified="2017-10-25" version="1">MKKFVVAALSSAALAVTLTACAHDEKTCCAPPASSVTPTPVPSDDGSGLRRNTSPSPAPPSGESARPHITLPHLTWPKRDPGAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBD0</accession>
    <name>A0A231HBD0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781316.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46027">
        <property type="protein sequence ID" value="OXR46027"/>
        <property type="gene ID" value="B7C42_00990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="7594" checksum="440238F7E44986AA" modified="2017-10-25" version="1">MNIRTILHRRQAESIPLLPDSESGPLAAAFRNHGRRSRRNLAEREERLERLLTPSELDLVEHRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBK1</accession>
    <name>A0A231HBK1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase [NADP(+)] 1</fullName>
            <ecNumber evidence="3">1.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gabD1</name>
        <name evidence="3" type="ORF">B7C42_01164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.79" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46199">
        <property type="protein sequence ID" value="OXR46199"/>
        <property type="gene ID" value="B7C42_01164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="17"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="486" mass="52017" checksum="7A85B8D5715A0778" modified="2017-10-25" version="1">MTSTNVQPMSASGPDAEPFETIDAYTGETLAELPYLATEQLDALLERADDAYRSWRAAPIEQRARVVSAAADLMRERKDDLARLITREMGKRISESEFEVDLAASILQYYGENGPRILQPTTLPVDEGEARIVNAPLGVLLGIEPWNFPLYQVVRFAAPNLVLGNTILLKHAKICALTAIELQKIFTDAGAPEGVYTNVFLRISDVEHVLAHPAVQGVSLTGSDAAGASVAEIAGRHVKKCVLELGGSDPFIVLDADDLDDTIDAATTGRMANTGQSCVAAKRFIVPDELYDRFVAGLAERFGALRPGDPSDPETTLGPLSSTKAADDLLEQVEDAREKGATVVTGGGRPEVPAPGRRDAFVDATVLTDVTPDMRAYSEELFGPVAVVYRVGDERGAIELANTSKFGLGATVYSSDPDRARAVAEQIDSGMVWINHPTSSQADLPFGGVKQSGFGRELSELGMFGFANRKLIRSLPRRTASAGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBL4</accession>
    <name>A0A231HBL4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5666 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781448.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46136">
        <property type="protein sequence ID" value="OXR46136"/>
        <property type="gene ID" value="B7C42_01101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043724">
        <property type="entry name" value="DUF5666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18914">
        <property type="entry name" value="DUF5666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5666" evidence="3">
        <location>
            <begin position="223"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="30543" checksum="8B06082AA583799F" modified="2017-10-25" version="1">MTNPSDPWAQRPDSPDTPTEKLGASGRHPDDGASHTTEYSEAYGQSPEPYESTRPYGHPGPYEHTAPYEFPSHPEYQGRYFEQSPGPNATRELPPYDGQWGAYESGYSEPGDYPPYGSGAPGTTAPQGAVGPTGLPVEPPRRSRTGLWIALTAAVFVLVVLGGIAAGLLLAGNDSSSSDAAATGRPAPTRVPVVPPNPSGGAKPSLPQLPGLGDIDGLGATMGTVNSNDGTTIMLQSLLGNSVTVHTDADTQVISMGTGKVSDLKQGDMVVVQGDKNPDGSIKAKIIISTQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBN7</accession>
    <name>A0A231HBN7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46117">
        <property type="protein sequence ID" value="OXR46117"/>
        <property type="gene ID" value="B7C42_01082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="819" mass="75704" checksum="69AE9850AFFFE000" modified="2017-10-25" version="1">MSDPNDDQKPHQGASGDRPRQAASGAGPDGPAKPGAAPTAPMPSPSAQTQVIRAPGTKNASAQPNFGAGDKSGAGAPGAKPGGSGTAGSGKPAAGATASKASDGGEPAEPAGAEKGAAGKPGTAPSGAAAGEAETVAIPRRGESGKKIGEPGKAPTSEEPGKSGAATGTAESAATNGPTTNGPAAAPDAERTAKGTKDPGAAKAGAAAKAGGAEGAAAGQGVADAARAAAPGSKAPNAAANENGSGTDESKTVALPKISSGKGGEKTAKSGPAQQSGGANSGRGATAPDPKAEAPQDVPAISNPSDDATTILPIQKPDPAATEKLRATPPGAGQSGPKRPGAQGGPGGEQGAPGAPGSRGPGGPAAGGPGPKGRVGGPAAAAGAAGLGAAAAAGAQRGPAGGAPGQSGTSGSGGPGQGPGGSGQGSGGPGQRVGAGPNGPAQQGPAGGPGTQGRGQGPQRPGGPNPQGPGSQVPGTQGPGAPGPAAQGLGAKGPGVQGPGTKGPNTQGTGAQGPVAQGAKAQGPGGPGPNAQGPKGPGAQGPKGPGVQGPGGHGPQGQGSPGPQGPGGHGPGAPGPRPGGPGMSGAAAALGAQGLKGSAAQGDQASRPGGAPSPADTKMTAPALSAQPNGPGAPGGPGGPNQPGGPQPVPPRPMAQPQRVPAAEPDAAPGRAARSKRWLLLAGGAVVVVIVAIVAVVALATGGSDNSPEAQVKGAVNSYTNALASGNLSQLQSATCGKLHDFYQNIAPDQYAGVHKLAVDQKKIPKVAGVDGVQITGDKAVAQVDIYTDADPSRSTARTFDLQQTDGGWKVCDPAGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBR5</accession>
    <name>A0A231HBR5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781550.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46262">
        <property type="protein sequence ID" value="OXR46262"/>
        <property type="gene ID" value="B7C42_01228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="451" mass="48275" checksum="C49842DAEB19DB81" modified="2017-10-25" version="1">MSVSVDVIGDDGTAVATKNDRPLPPSQDPFYRAPADIATHAPGTVLRSRPVQIALLGLIPQRVTAWQLLYRSNDLHGRAEVAVTTVLLPADAEPGERRPLLAFESAIDAVSERCAPSYALRRGAVVPGSITQLELLLVANALRRGWAVSIADHEGPDGRFGAPREPGYRSLDGIRAAMHFRPLGLSNDTPVVVWGYSGGGMAGSWLVEMAPTYAPELTIAGAVLGAPVGDPGEVFIRLNGGRYAGFPAIVISALRQVYPALGEVLDGRISAAGERLLERAAQLPPIVALARLAGQDVSKYLDRPLEEVLSTPAMCDMFDDMRLGQHTPHCPILVIQPLHDRIIDVSCIDAQVERYRAGGAAVGYLRDRLSDHFTLLPLATPLSLEWLADRIAGLPVTDADTDTRTVWSVVASPSRWRGLVELAGTAGRMLLGLPLGKQSEPQLPDEQPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBZ4</accession>
    <name>A0A231HBZ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.222</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiG_1</name>
        <name evidence="2" type="ORF">B7C42_01183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.222" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46217">
        <property type="protein sequence ID" value="OXR46217"/>
        <property type="gene ID" value="B7C42_01183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="25107" checksum="BF431F3B1D504A2E" modified="2017-10-25" version="1">MDAAEWDERYAQSELVWGAPPNATVVEHIFGLERRVQLVPDAPGEEPPELPRALDLACGEGRHALWLATHGWQVRAVDFSQVGIDKGRTVASRLSRSVRSRIDWECADVTDLAGAGIDGPFELILAVYIHLPAEQRRTLLLSAAERLSPGGTLLVLGHDTTNIADGYGGPQDPAILFTPDDVVADLAAAEHIRVDTAQRVIRETEGRDAIDALVVATATVPDLEEQATATPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC51</accession>
    <name>A0A231HC51_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46277">
        <property type="protein sequence ID" value="OXR46277"/>
        <property type="gene ID" value="B7C42_01243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="194" mass="21170" checksum="5E37A9806DB94DD1" modified="2017-10-25" version="1">MRHGHGRGFGRPGGWQQADLPDAADAPDWFAGRLPSEWFNGPATIEIDRDEIVVIGELALPAPESGDDDAAGSEPSAATVDGLIARFRESTRPARMQIAQEAQARYGRNVAWGVSVNGERTLFTHLSVPVMTRLRQPERKVLDTLVDAGVARSRADALAWTVKLAGKHAEEWLAELRTAMRKVDDLRAEGPRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC71</accession>
    <name>A0A231HC71_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">drrB_2</name>
        <name evidence="10" type="ORF">B7C42_01263</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46297">
        <property type="protein sequence ID" value="OXR46297"/>
        <property type="gene ID" value="B7C42_01263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="10"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="27103" checksum="B1647FD5550B6912" modified="2017-10-25" version="1">MTTYTLADSRTMLRRNLLHAKRYPGMTISMFIMPLVMLLMFNYIFGGALEKATGGSYIDYLVPGMMLIIPAYLVVGVAVAVASDMTKGIVNRFRTMPMAHSSILTGQVAGTVIQGVLGVGLMVAVAVLIGFRPDATIVEWLAAFGLIILVIFGLAWLGVGFGLAAKTPEGASNTPTPLIFLPFLGSGLAPTDTMPAGVRQFAEYQPFTPLTETLRGLLMGTAIGGNGIAAVAWCVGFAVVGYLWSRSLFRRKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCF8</accession>
    <name>A0A231HCF8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46509">
        <property type="protein sequence ID" value="OXR46509"/>
        <property type="gene ID" value="B7C42_01479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="201" mass="20239" checksum="BA2EF8950D2D669A" modified="2017-10-25" version="1">MLHRARTATGSPPHRRAVRRPGIDGLRGGLVGMAVVVLAAAAHGWAGGGYPGSATAALLLLSAAVAGTFASMLPPAGGAWRRAGVAAALGGGQAASHIALSLLPAHGPGETSCGSGHSGLTSIFPSSWMMLAHTLATVACAALIVAVEHLYAAVSHSVRAVTTRPLPPVDITTPRWRTAARPAWQQWRAGALGSRAPPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCH3</accession>
    <name>A0A231HCH3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1775 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46508">
        <property type="protein sequence ID" value="OXR46508"/>
        <property type="gene ID" value="B7C42_01478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353200" description="DUF1775 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="22135" checksum="22E336232B823E46" modified="2017-10-25" version="1">MSTSLSRALVATGAAAGLALLASGTAAAHVTADAPGAAQGGYAVITFRVPTESATASTTKLTVALPQLSAARTEPVPGWTAKTEKNDKNQFTSVTWTANPGSPGITPEQFQRFALAVGPLPKQDKISFPATQTYSDGKVVNWNEPMPAGGDEPEHPAPSVTLAAAGSEHDHAAGMSSETDSDESDSDNTARWLGGIGLVLGALGAALGLGSLIRSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCX5</accession>
    <name>A0A231HCX5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xerC_2</name>
        <name evidence="6" type="ORF">B7C42_01674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46699">
        <property type="protein sequence ID" value="OXR46699"/>
        <property type="gene ID" value="B7C42_01674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="94"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="30777" checksum="1AECDADC34E1DA71" modified="2017-10-25" version="1">MQYSNYLRAGGSAESTIERRTSDLEQIAREVGPDGPATITGEMLVQWAGTKDWSLETRRGRRSSARSFWKWALAAGRVTEDASAAWPHVPPAVPRPRPVPDRIYRPAVEAAAPRVRLMLRLGAELGMRRAEISCVHVGRDLSEDVDGWWLIVHGKGRKDRTLPVPDELARHIRAGAPGHSPGLGHPRTGYLFPGRIDGHLSPRRIGELCSAVLRAQQEEGEDDWTTHKLRHRFGSRALRNTRDIMAVKTALGHVSVATTQVYCAIDRSEVRNAVNSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCZ5</accession>
    <name>A0A231HCZ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46666">
        <property type="protein sequence ID" value="OXR46666"/>
        <property type="gene ID" value="B7C42_01641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011231">
        <property type="entry name" value="Phage_VT1-Sakai_H0018"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09956">
        <property type="entry name" value="DUF2190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="11956" checksum="C0CA7DC90388D6C5" modified="2017-10-25" version="1">MSGDYLPLFDPGDQIPMVTGAPVTAGQVLYVSADNTVSATATAVVPIGIAGQDDPVGGATIMVKRRGVWVLAASGAIAAGALVIPAAAGAVATIASDTNYGHVVGSALAAAANNKVTVALRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDF3</accession>
    <name>A0A231HDF3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator FurA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">furA_1</name>
        <name evidence="3" type="ORF">B7C42_01804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775502.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46826">
        <property type="protein sequence ID" value="OXR46826"/>
        <property type="gene ID" value="B7C42_01804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="15159" checksum="4F5F8E8430CA2BFA" modified="2017-10-25" version="1">MHTEGFDPRERLRAAGLRVTRPRVAVLEAVAAHPHSDADRVAAAVRQELGSVSTQAVYDVLHACVGAGLLRRIEPAGSAARYETRIADNHHHLVCRNCGTVVDVDCAVGRAPCLDPSDAHGFTIDEAEVVFWGLCPQCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDT2</accession>
    <name>A0A231HDT2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46905">
        <property type="protein sequence ID" value="OXR46905"/>
        <property type="gene ID" value="B7C42_00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="62" mass="7314" checksum="6AD9FB5F6F7CAA3C" modified="2017-10-25" version="1">MTQQRGVSQPEHDSGRRSENYRTRDPGDLAQPPNESHFRRLRRALTRGHRTITHIDHPMNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEB6</accession>
    <name>A0A231HEB6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47118">
        <property type="protein sequence ID" value="OXR47118"/>
        <property type="gene ID" value="B7C42_00240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="718" mass="80383" checksum="ECD6BF352465A2AD" modified="2017-10-25" version="1">MPDHQLPALIIHDGRLPGGLGATVLGRLMSRSGQPLREVRALNREQNAFSFWTEGVEHLLSLPNVENTKLILFDITYYDVDPNFCNDALDRLDVRFGELEVWSNRWPGGYVHSNRHVKIPPDDIVYTDLGRYLNMDEKQLLRFALTAAETIPTAALSDDVRRAGALAMWIETDPPTRWRQLLETDKLGDVLAQSEELEVAPSRSREATVHDDSLAEQGFIDIEITPQAARSELPVIDALCRERNVPPSAVILAWLGRERVLLIRRDTSFSYPALRWQIENRHADLVPDAYRGRHYGPQDAVYYRIDSTTHERSQLRPQFRNLASRLAVTQSGGRYLPAGLARVIAQIANSVLQSTDLTGAYTGAPPAIEVAAQDLYVLLHQSSRTGKWRQTLTIPIHVRDAGATAFLYRDNGYNLQKAERLMEGALIGLAQRQLEWLGDTRQPVRLRIDVRHEMRESRREFTREVQSALQQPRMSPIPADVRYVSSDSLIGRFLKMCDMHKLVCYDESETIGPSVAHALTLLATARTVQGGKAGARVLDLFSGSGVANRLLSRFGHQVTSVDKYVSAASVEVNAEHGDGLWLRADARRVLDEKEPIIEQAFDVIGLDPPHAELLELLFGGSERASLVELCATRANTMVMYQGHSTQLGRLRLVYEGLVAAGWVHVRILQVEEEIIVVAGTSAMTEFNDFYARVIASLKSIVEENKLGGLDIWTVFSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEJ3</accession>
    <name>A0A231HEJ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_00504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47381">
        <property type="protein sequence ID" value="OXR47381"/>
        <property type="gene ID" value="B7C42_00504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027787">
        <property type="entry name" value="Alpha/beta-hydrolase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027788">
        <property type="entry name" value="Alpha/beta-hydrolase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10081">
        <property type="entry name" value="Abhydrolase_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15420">
        <property type="entry name" value="Abhydrolase_9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9_N" evidence="4">
        <location>
            <begin position="485"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9" evidence="3">
        <location>
            <begin position="680"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9" evidence="3">
        <location>
            <begin position="834"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="906" mass="95480" checksum="7ED04F170FB81401" modified="2017-10-25" version="1">MPSAAMPGRAGTYERFVRHWRRGYLPGIVGVAAVVAAVIAMLVALSPGAGAAEIGPASENTAARDAVRALTGDRPGLAVIPADFAATQGYRPVEMAGMPVDPSGECSSPVPLPAEFDTACKAHDLGYDLLRYAELRGHPLGAWARRAIDNALETRMFAACDTRDDLLARARCTTMASVATAAVDLNSRRQNYAAPMPEYLFGRQLSGTELGPQLAHILVRVGMVLLMVAALFAIVRRTVRPRREGQCTAPPSSSWLPGSDSNRGASAARRWRRRSGGSTGNHDRRVLPAAHIGAAASRTARGARKWLSRNAVQLRRVIARGFDGIGLWPGAPATAAAGGGAGGWAAERARPAVAALELSPLQRPGTRREISRTQPASDRRRTATQGTSAGTGRNGNHLSTPKHYHRPAGTTGAPGTSSSVGVPDATVRTCFAPPSPGEATATTPSSHSSERARHALGTAIRRLVTIGKPRTGTPMASAAGISASLAPGLLPRTSVAQALLTAVLVLIALSVAGLGRKVLGHWAIDTEARTMRFRSAIVIACCAVTAAALIHAWYWQNRLREAMNFPPVGVRYWLQWAFGVVAVVVPIVLVLRGLRWAAGYVGRLRAAALVTATVLACQFALLPAVVNWQRSAFASADAAMDPTLVRPVSYTRSGSPDSAVSWASLGAEGRKFVTERGRSVRVYIGLNSAPDLDSRVALAIREIERSGGFDRGHLVVMVPTGSGWLDAGAARGLDERFDGDATLVGMQYSQAPSWATFLFARAEAERSAQALFTGIERHLAGLAHPPKLYVYGQSLGATAGSAIFADDRDESARVCAALWAGPPASAVHRGGATVLANSSDPVVQWSPRLLWRAPDLTGTRHDAPHPMWLPGLSWVQTTADMLSALAPGPGHGHRYGADQGTALGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEL6</accession>
    <name>A0A231HEL6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative murein peptide carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ykfA_1</name>
        <name evidence="6" type="ORF">B7C42_00239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47117">
        <property type="protein sequence ID" value="OXR47117"/>
        <property type="gene ID" value="B7C42_00239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="181"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="32488" checksum="42EB70DBFB5F01C4" modified="2017-10-25" version="1">MNHLSNDTATLPWARLRPGDTVRLVSPASFPDDASTIDQLAETLQGWGCRVEVADHALDRHGYMAGRDEDRVADLNAAYADPAVRAIITTRGGAGAYRLLEGLDYGAIRADPKPLVGFSDITYLHLAIWHHCRVSGIHGGLAGLHAIDSVHHLLTNPEPYALERNPVLQSAAVESPGRARGFVIGGALAAMAGMVGAGLADLSGAIVAIEAQRHVGLGHIDRQLTQLIRSGALDHVAGFALGRFHGFEDYTDRGWNLVDVLRDRLVPLGKPILGGLEFGHGPDPRAIPLGTIAELDTATGRLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEQ9</accession>
    <name>A0A231HEQ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG3_1</name>
        <name evidence="1" type="ORF">B7C42_00318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47196">
        <property type="protein sequence ID" value="OXR47196"/>
        <property type="gene ID" value="B7C42_00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="25994" checksum="0B016BE78B180BDA" modified="2017-10-25" version="1">MLDLTGKVALITGAARGQGAAEARLFVERGARVVLTDVLDADGKQLADDLGEAARFVRHDVTSAGDWNAAVAVAVSEFGALNVLVNNAAIYTAKPLTDTTPEELEKILQVNLVGAFRGIRSVVGPMSEAGGSIVNISSQAGLEGLMGHSAYGSSKWGLRGLTKTAALELGPMGIRVNSVHPGPIATPMVPYLTTGPGSFPTLPLQRTGVPEEVAELVAFLASDASSYVTGAEVTIDGGLAAGKFMPPESQEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEX4</accession>
    <name>A0A231HEX4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xylose transport system permease protein XylH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xylH</name>
        <name evidence="7" type="ORF">B7C42_00562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042882.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47439">
        <property type="protein sequence ID" value="OXR47439"/>
        <property type="gene ID" value="B7C42_00562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="36287" checksum="DC679E891F166817" modified="2017-10-25" version="1">MNDTATVSESTTPAAIGPSLVNRLIVRPEIGAGLGALVVFAFFAVITDRFLSPLGVATWLDDASTLGIMAVAVALLMIGGEFDLSAGVMTASTALVTAMLSVHAGWNVWFALGASLLFALAVGALNGWVVMRTGLPSFIVTLGTFLALQGLNLGVTRLVTGTVQVSGIRSAPGYASAGWVFAATTNLGDARIQASVLWWIAVTAVATLVLVRTRFGNWIYAVGGSLPSARAVGVPAARTKILLFMGTAFAGWIVGSCNLLRFASVQANQGVGLEFQYIIAAVVGGCLLTGGFGSVLGAAIGALIFGMARQGIVFARWDSDWFMLFLGVLLLAAVLVNNAFAKRAERLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF63</accession>
    <name>A0A231HF63_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47613">
        <property type="protein sequence ID" value="OXR47613"/>
        <property type="gene ID" value="B7C42_00738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="35" mass="3827" checksum="16BCA77D7BF74512" modified="2017-10-25" version="1">MLADDTVETLAARVLEAEHVVLPLVVRRIAAGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFE8</accession>
    <name>A0A231HFE8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="9 10">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">miaB</name>
        <name evidence="15" type="ORF">B7C42_00828</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="9 10"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47703">
        <property type="protein sequence ID" value="OXR47703"/>
        <property type="gene ID" value="B7C42_00828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="162"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="412"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXR47703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="530" mass="57083" checksum="AC5A112316E873EC" modified="2017-10-25" version="1">MQVAAHSAAGRAPGSATDPRSPRTYEVRTYGCQMNVHDSERLSGLLEDAGYTKATGGRTADLVVFNTCAVRENADNKLYGTLGHLAPIKAERPGMQIAVGGCLAQKDRDTVVRKAPWVDVVFGTHNIGSLPVLLERARHNEQAQVEILESLEAFPSTLPARRESAYAGWVSISVGCNNTCTFCIVPSLRGKEVDRRPGDVLAEVQALVDQGVLEVTLLGQNVNSYGVNFAEPALPHGHPADFAPEHRDRGAFAKLLRACGSIDGLERVRFTSPHPAEFTDDVIEAMAQTPNVCPQLHMPLQSGSDRVLKAMRRSYRKDRYLGIIEKVRAAMPHAAITTDIIVGFPGETEEDFQETLDVVRQARFTSAFTFQYSIRPGTPAATMADQVPKAVVQERYDRLIELQEQISLEANRALIGTEVELLVAEGAGKKNAATARMSGRARDGRLVHFRPGAAAIRPGDIVTVDITEAAPHHLIADGPIHSHRRTRAGDAHERGVLPKTAPIGVGLGLPRIGAPEPLPAAAGCDTGCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFJ9</accession>
    <name>A0A231HFJ9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47654">
        <property type="protein sequence ID" value="OXR47654"/>
        <property type="gene ID" value="B7C42_00779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024532">
        <property type="entry name" value="DUF3830"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12903">
        <property type="entry name" value="DUF3830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="18695" checksum="A8F406869E9B6839" modified="2017-10-25" version="1">MARYLTITLTKAGVRCRARLLDDQAPRTCAAVWDALPQEGDAFHAKYARNEVYTLVPRITAAPHRENPTVTPIPGDVCLFDFEPWEIGNPAYGYEPGSAAHAEQGATDLALFYDRNNLLINGDMGWVPGNVFATIEEGLPELAAACNALWLRGVEGETLSFTRCLDAGQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFQ1</accession>
    <name>A0A231HFQ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adhT_1</name>
        <name evidence="2" type="ORF">B7C42_00926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47801">
        <property type="protein sequence ID" value="OXR47801"/>
        <property type="gene ID" value="B7C42_00926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="32321" checksum="ED7A24A56B64BF4C" modified="2017-10-25" version="1">MRAIIVRDRDSGIAGLTVTDMPYPHAAENDVVVRVHAAGFTPGELGWPATWSDRAGRDRTPAIPGHELAGVVVELGYGTTGLTVGQRVFGPTDWARDGSLAEYTAVEARNLAPLAADIDYTVAAALPISGLTAWQGLFDHAHLTCGRTVLIHGAAGGVGSIAVQLAREVGAHVIGTGRAGDRDIMLGLGAQAFLDLDGDDLRDAGAVDVVFDVIGGRILERSTELVRPGGTLVTIAMPPTTQPRDGRAVFFVVEPNRVRLADLAERVRNGRLEPVVGSVRPLAETASAFARRHRTPGRTIIRVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFQ7</accession>
    <name>A0A231HFQ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arylmalonate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.76" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47648">
        <property type="protein sequence ID" value="OXR47648"/>
        <property type="gene ID" value="B7C42_00773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047436">
        <property type="term" value="F:arylmalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="26088" checksum="FEF5AD7FF6B99E5D" modified="2017-10-25" version="1">MQRIPTVGFIYPDHAAEDEYPWAAAQLGVDLRVAHIYGTDLHAVPELLDLGSPEKLREGARLLASCTPRAVVWACTSGSFVYGPQGARDQVDRLARDCGVPASSTSFAFVDAVRAIGVRDVAVCASYPDEVAALFVDFLAAADIRVVSMSSAGIDTAAEVGTLTPEQVLALAVANDHPDAEALLVPDTAMHTIQLLPELESALGKPVLTANQVTVWQGLRLADLPAVSPPSGPGLGTLFSERPIHVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFX3</accession>
    <name>A0A231HFX3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="2">FNR</shortName>
            <shortName evidence="2">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yumC</name>
        <name evidence="4" type="ORF">B7C42_00975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779644.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47850">
        <property type="protein sequence ID" value="OXR47850"/>
        <property type="gene ID" value="B7C42_00975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="15"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="35025" checksum="395135EC401662D8" modified="2017-10-25" version="1">MNTSSIASGAELDVDILIVGAGPAGLYGAYYAGFRGLRVAVIDALAEPGGQVSAMYPEKAILDIAGFPAIKGRDLIDGLLAQAAPFDPIYLMGEQALGLTHDAFGNAVVATDAGRRITAGAVIVTGGIGTFTPRPLTKGLDFLGRGLSYFVPDLSEHAGKDVVIVGGGDSAFDWAMHLEPIANSVTLVHRRDKFRAHKSTVAKVYDSSVRVLVNADISSVRGNGWIAEVDVAHRADKSTTTLPAQSVIAALGFTADLGPLTEWGLEIDSRHIVVNTRMQTNVDRVYAAGDITDYPGKVRLIAVGFGEAATAVNNAAAVLDPDAEIFPGHSTEQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFZ0</accession>
    <name>A0A231HFZ0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CbiG_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47617">
        <property type="protein sequence ID" value="OXR47617"/>
        <property type="gene ID" value="B7C42_00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_C" evidence="2">
        <location>
            <begin position="45"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="164" mass="17297" checksum="1C9F61C51A845D4E" modified="2017-10-25" version="1">MRTDSLRRDRGAGITPVPDRNSSLRRTRPAFDHRPGKRGSMSGAVVVGIGSRPDPAAEAIVAAVRKVMGHTAIRCLATIDRRAEEPGIVAAAAAFEVPVIGFGADELAHVDVPHPGDRAAVAVGTPSVAEAAALLAWRRWGRRGRLIVPKTVFGTITIAVAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFZ1</accession>
    <name>A0A231HFZ1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE</fullName>
            <ecNumber evidence="2">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiE_1</name>
        <name evidence="2" type="ORF">B7C42_00929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47804">
        <property type="protein sequence ID" value="OXR47804"/>
        <property type="gene ID" value="B7C42_00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="123" mass="12917" checksum="A27E5733903B41E3" modified="2017-10-25" version="1">MVNVEAFEKYRANDYLRRLADSDIGRHYKAIALEQLDIQPGHTVVDLGCGPGADLGSFAAATGPAGRVVGIDSDAAALTEARSDIRAGEPIALYTATFTVSAFPGLPSIAHTPTGCCNMWPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HGI9</accession>
    <name>A0A231HGI9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">alkH</name>
        <name evidence="4" type="ORF">B7C42_00961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47836">
        <property type="protein sequence ID" value="OXR47836"/>
        <property type="gene ID" value="B7C42_00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="21998" checksum="F433BFA842C2CDF1" modified="2017-10-25" version="1">MNAEVAGTLKAIDYALEHLESWMEPAVREPGLGQSSVCIQYEARGVCLLFGPWNFPFNLVMKPLVAIFAAGNIAIVRPNEPAPATSAVTVAILREAFEPHEVAAFGGDASLAERLPSTARPLRRRGARVIGRPEFDEESRTIAPGVLLDVPLDSQILREEIFGPLLPYRFSTRFRELSHARSVVAPNLMIMTNSSFQGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSN2</accession>
    <name>A0A231GSN2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000112">
        <property type="protein sequence ID" value="OXR39639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064908131.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000112.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39639">
        <property type="protein sequence ID" value="OXR39639"/>
        <property type="gene ID" value="B7C42_08293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="32946" checksum="BE4BC597BF713802" modified="2017-10-25" version="1">MASLAVAGRADLTDAQWARLEPLLPRGKKAGRPPKWTKRQLIDGIRWRCRVGSPWRDVPAEYGSWQAVYGLFRRWQRAGAWAAIVTSLQAVADAAGVIDWQVSVDSTITRAHPHAAGARRDGAGQAEPPAGPGQSEPGDHGLGRSRGGWTSKLHLACDQGCRVLSVLVTAGQAGDSPQFTAVLEGIVVPKLGGGRARARPERVLADKAYSGRGNREWLRRHGIRATIPVPADQAEHRRRRGRGGGRPPAFDVAIYRDRNAVERGINQLKQHRAVATRFDKLAVRYQATIHVAVINQWLRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSW0</accession>
    <name>A0A231GSW0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000081">
        <property type="protein sequence ID" value="OXR39714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780511.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000081.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39714">
        <property type="protein sequence ID" value="OXR39714"/>
        <property type="gene ID" value="B7C42_08216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7263" checksum="3FAE27AFDDC4565C" modified="2017-10-25" version="1">MVKPPLPQRRPSDDIQASWSASIALLDSLLTALQAWQPSQLPPAAPTEQDIAVLAAFGTKVPNHSFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSW9</accession>
    <name>A0A231GSW9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative aminoacrylate hydrolase RutD</fullName>
            <ecNumber evidence="1">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rutD_6</name>
        <name evidence="1" type="ORF">B7C42_08288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000105">
        <property type="protein sequence ID" value="OXR39645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39645">
        <property type="protein sequence ID" value="OXR39645"/>
        <property type="gene ID" value="B7C42_08288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="120" mass="12607" checksum="BAF44B05C721AF15" modified="2017-10-25" version="1">MVLLSGYSAAFTNSLPDEVFSRYLAQIAAQVPGGAAAQADLVARVDTRADLPRVAVPTRVIAATADLLVDPANSRELAAAIPGADYVEVAAGHVLMHEAPQAWHRAVLDYFADSSRIHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT12</accession>
    <name>A0A231GT12_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000070">
        <property type="protein sequence ID" value="OXR39763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782110.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000070.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39763">
        <property type="protein sequence ID" value="OXR39763"/>
        <property type="gene ID" value="B7C42_08164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="480" mass="53757" checksum="EB9A68418E22AFE8" modified="2017-10-25" version="1">MTETSTFLDAIAELDHNITGDRRAARRTFTTALTHATPAEREVLDDMVDTFTLYPYRTALLRLDAAFRYDEPKRALLTRLLPGTDPGLHVRERAERIAILDQRARANGSSVDDEAFRDYAPLTAAETDRTSIRLWRNPPARVYLAPSRATDKSRMTPEQITARVRARGKRRPALVEPDVVAAYVADNLHRDTMAGELARIRASEQRFRDLGLLAEPTPSSAVRVQGAQPRSDEDVRARWDLEFVHHVADQHAHDAANAEPSRRISHDNALAYAEARTGVRGDLRPEVPFQGNSVDYTREAMTPISGWRCVACFIERSTRDQDPIHSDSGRRRSDDGLCDYCRGDDRTPRLPELPTGFTATDLARTYCRFLTTTHPGAAPALLAETRRRAPRWLISIIDEFSLQPEHTENANDPLADVETDAAQAKPPTPRRRGPMTGAGQRQARCEGCTRIRAIHDDGFCTECRVWLGLVTPPTRQTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT37</accession>
    <name>A0A231GT37_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hmgA_3</name>
        <name evidence="4" type="ORF">B7C42_08291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000109">
        <property type="protein sequence ID" value="OXR39641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39641">
        <property type="protein sequence ID" value="OXR39641"/>
        <property type="gene ID" value="B7C42_08291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR39641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="372" mass="41032" checksum="F64D45F3FDBB8B4F" modified="2017-10-25" version="1">MGEEGFTGDSSLLYHRGLPPAIVDSSAWRPPNSRTVPNHPLRHRHLRLHELFPDAVLAQTDVVTGRRLILGNDDVRISYVAALRESPLYRNAIGDELVYVESGSGVVDTVFGRLPVRTGDHVLLPRATTHRWRPDGPEPLRGYIVEATGHITAPKRYLSAFGQFLENSPYCERDLHGPAEPLQESGAEVEVLVKHRPGAEILGTRMIYADHPFDVVGWDGCLYPYRFNIADFEPITGRVHQPPPVHQAFAGTNFVICDFVPRKVDYHPLSIPVPYYHSNVDSDEILFYCGGSYEARRGSGIGPGSVSVHPGGYAHGPQPGAYERSIGVEYFDELAVMVDTFRPLGLGEGALACEDPDYAWTWSGRGPSSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTN0</accession>
    <name>A0A231GTN0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782412.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39938">
        <property type="protein sequence ID" value="OXR39938"/>
        <property type="gene ID" value="B7C42_08001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="308" mass="34469" checksum="CAD6A18CDD8864DE" modified="2017-10-25" version="1">MSATCACGAPAYGRGKCFNHYQVHRNRQIAYGRWEPQPLLPADEVRAHIEQIQAKGIRSRRLAQLAGVDPETLRRITRLPDAQVTPEIRKSILAVSVPERAADLVPDNALVPIHGARRRVQALVAFGYPRAELARQLGVATNSNAMNVLFGHRRDGGPQVGQSIMAKRDREVKELFDQLQLVPGPSDQARAHGRRKGWALPFEWDEQALDDPNGRPIKARWNSQSAVEERREQVADLTARGWTVTQIAQQVGATDRTVLRDRARHREQPEIAATQQVSEIEAMGELAVQARRDIAARRAAPTVRERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUC5</accession>
    <name>A0A231GUC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000036">
        <property type="protein sequence ID" value="OXR40227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40227">
        <property type="protein sequence ID" value="OXR40227"/>
        <property type="gene ID" value="B7C42_07652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="101" mass="11426" checksum="E62399BC267B3E14" modified="2017-10-25" version="1">MGFPITIPAPTTILSRTAPIEELAKYDKRDETLIIELDEIDQAGVSYTRSALVKTITAKFDRAADPQRTIVVEFAHPDLEPRTFPLGEQVTVHYLTYEHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUF0</accession>
    <name>A0A231GUF0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prmC_2</name>
        <name evidence="6" type="synonym">prmC</name>
        <name evidence="9" type="ORF">B7C42_07727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40212">
        <property type="protein sequence ID" value="OXR40212"/>
        <property type="gene ID" value="B7C42_07727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="31918" checksum="6EC389D97822FFE8" modified="2017-10-25" version="1">MMQAPGEAGQHRVPLRPAIIEAARTLAAAGVHSPQIDAEFLAAFVLEVERSRLALIPMVTPEQLERFRKLVARRAERVPLQHLTGAASMGEVDLEVGPGVFVPRPETELIFAWALAQLEAAGHEHPPIVVDLCTGSGALALAIANARPDAEVHAVEIDPTARQWAQRNADRQAAQGDTPIVLHAGDVTDAQVLAALNGRVDVVVANPPYIPSGARLDPEVAEHDPHLALFGGPDGLEVIAPMVATLARLLRPEGVAAVEHDDSHGPQVAALFAGDGRFCDIVEHPDLAGRPRFVAARRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUM2</accession>
    <name>A0A231GUM2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfide dehydrogenase [flavocytochrome c] flavoprotein chain</fullName>
            <ecNumber evidence="2">1.8.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fccB</name>
        <name evidence="2" type="ORF">B7C42_07585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.2.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909914.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40324">
        <property type="protein sequence ID" value="OXR40324"/>
        <property type="gene ID" value="B7C42_07585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070225">
        <property type="term" value="F:sulfide dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="179"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="391" mass="40479" checksum="E5ED92A17C99B50E" modified="2017-10-25" version="1">MSKTVVVLGAGVGGLTAATELRKTLPAQDRIVLIDRGFDGTLGLSLLWVLRGWRSTEQVAVRPSAAALPGVDRVTGQIERIDLDSRTIDCGPAGTIGYDALVIALGASLDLDRLTGLSAALEAGVAGQFYTADGAADLHNKVEALETGRVMVLVASTPFKCPAAPFEAAFLLADQLGEKFTSTQVRVDVFTPDPLPMPVAGPAVGNALVDMMAAKGIGFHGGTSATRVDPSTRSVEFADGSTETFDLLAVVPPHAPGAAVASTGLGPNGWIPVDAGTLATATAGVYAVGDSTALLLPNGKPLPKAAIFAEAQALVAAHQVARHLGYDAPDTRFTGKGACYVELGDGLAAKGEGEFLASPAPQVSLREPSAAYHHEKEQQERDWLARWNIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUY8</accession>
    <name>A0A231GUY8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-dehydroadipyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">paaF_7</name>
        <name evidence="1" type="ORF">B7C42_07501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000032">
        <property type="protein sequence ID" value="OXR40443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042665.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40443">
        <property type="protein sequence ID" value="OXR40443"/>
        <property type="gene ID" value="B7C42_07501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="27684" checksum="497E91FA18494C66" modified="2017-10-25" version="1">MSFVEVERAGSVAIVRLNRPERMNALGTEILAELRDAYARIDSDDDIAVGVMTGTGRAFCAGRDMKEANTGEVDLSEQATTKNIDLYMENNRAKPMISAVNGYAGGAGFYLATRAVDLVLAAESASFQIAEVPRGILHGWQTGYWFNLSHAASMELAYGFRISGRRAYECGLANMVTGDGELMDVAMRWAEHVAAMPRTVLQANRQLRSRLENEVPASVDVDGSRMFREILDSGVAAEGDRSFLEKRTAQFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV56</accession>
    <name>A0A231GV56_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40510">
        <property type="protein sequence ID" value="OXR40510"/>
        <property type="gene ID" value="B7C42_07449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="29"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="286" mass="32413" checksum="AB67886321D2F892" modified="2017-10-25" version="1">MKPSVLAEACRQVQLRCDDARLLRAHSASVYLLPTERAVARISFPEHEGLRPERSPAIARWLLSQGYPATEPLLDHAIELDGATVTFWVYYPQDAVDIPPASKLGGLLRRLHALPAPPFPLPEYQPLAGLGLALDEPSTLSEDNREWIRERREVLVDQYQRLDSYLGVGLVHGDAYTGNTLWDGDEVLLGDWDEASIAPRELDLINVYQDIRYGTPESELSAFSEAYGWDARDWPGFTTLRDMRDLHTLTGFIRRSLRDPFVAAELQLRIEVLRNPDDRRLWSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV84</accession>
    <name>A0A231GV84_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40540">
        <property type="protein sequence ID" value="OXR40540"/>
        <property type="gene ID" value="B7C42_07349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="16444" checksum="E269A59313409408" modified="2017-10-25" version="1">MAIKRMDNVLIVVEDIDAVIAFFVELGMERENKGPVEGRWVERIIGVDDVRQEVAMLRTPDGHGRVELAMFHEPQPVRSEPRHAPANTLGLRRIMFAVDDIDDVVTRLRAHGAELVGTVEQYEQIFRLCYVRGPEGIIVGLAEEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVI1</accession>
    <name>A0A231GVI1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-gulono-1,4-lactone dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780073.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40481">
        <property type="protein sequence ID" value="OXR40481"/>
        <property type="gene ID" value="B7C42_07419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="48291" checksum="37D7C2144C4C428C" modified="2017-10-25" version="1">MTNSWVNWAGDQRCAPATYAAPRTRDDVAELLARAETEGHTVRVAGAGHSFTDTVLTDGTLLQLSQLNRILQVDRATGLARVEAGATLNELSTALHPLGLAFPNLGDIDVQSIAGATATATHGTGAALQNISAALHSVELMLADGSVVELDERSDPDGWRAARVNLGALGVVTAVTLQLVPSFVLEGVERPVPVEEVLTDLDEFVDGNEHFEFYMFAHSPLAMTKRNNRVQLAEQPRAKAVDWFADILMSNHTFDALCRLARRQPSLIPWIHRGAAYAGSYRRQIDRSYRVFASPRLIRFTEMEYAIPREYAVDAIREIKAVGQHFDSPMPTEVRFVAPDDAFLSPAGGRDTCYIAVHQYRGMEYEPYFRACEAIFDRYHGRPHWGKRHFQTAETLRGRYPEWDRFQDVRRRLDPKGRFANAYVERVLGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVM7</accession>
    <name>A0A231GVM7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40679">
        <property type="protein sequence ID" value="OXR40679"/>
        <property type="gene ID" value="B7C42_07237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011238952" evidence="2">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="7984" checksum="35EBF34DAA862B12" modified="2017-10-25" version="1">MKMMKSKLAKAAVAGGVVLGTVGIGAGVASADPGHQQQQPAPEQHQPTQQHQNQQPNPQPAQHGFWLFGQWIPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW10</accession>
    <name>A0A231GW10_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1775 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40817">
        <property type="protein sequence ID" value="OXR40817"/>
        <property type="gene ID" value="B7C42_07101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012195442" description="DUF1775 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="3">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="22672" checksum="1CEEB5A014A44BCB" modified="2017-10-25" version="1">MNESWFRRAALAGIATAAATILAAAPASAHVTVSGPDAARGGSAVLTFRVPNESATGAATTQLSVRLPALTEAETEPVPGWKTKVTRDDNHRVVAVTWMADPGGGIGAGQFEQFSVLADGLPDSETVTLPATQTYADGRVVNWDQPTSGNTEPEFPAPTLALAPAHEGGAQNHGDVHAAAAAEEHETDTTARWLGSIGIVLGALGVLAAATMFTRNRSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW97</accession>
    <name>A0A231GW97_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036499276.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40845">
        <property type="protein sequence ID" value="OXR40845"/>
        <property type="gene ID" value="B7C42_07129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12581" checksum="4B2770944AA8B921" modified="2017-10-25" version="1">MLINVVADSQTDGDIQPPDGDDSLTPRQSAAAIFSRRLSELIAESVVSTEDGSTRSLTLYSLAQHLELAYPDVPVSQSGLYRLVHGEAIPRLDLIIALARVFDVPPEYFVTERPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWG7</accession>
    <name>A0A231GWG7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">dut</name>
        <name evidence="7" type="ORF">B7C42_06930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40964">
        <property type="protein sequence ID" value="OXR40964"/>
        <property type="gene ID" value="B7C42_06930"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="6">
        <location>
            <begin position="70"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="218" mass="22249" checksum="834A14BD13558C18" modified="2017-10-25" version="1">MGLVGHHIMLGQADIFAVGGSRCAPSATAVDRCRHIGARRSHGPAAGRVGSLDVTGIAPIPLLRLDPGVPVPTRAHPGDAGVDLCTTEDVILEPGERVLVGTGIAVALPVGTVGLIHPRSGLAAKTGLSVVNTPGTVDAGYRGEIKVCLINHDPRTAIQLRRGDRIAQLLVQRVELVDFVEVDQLDETSRGAGGYGSSGGHHSLSPQSGGAGRAGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWH7</accession>
    <name>A0A231GWH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">K(+)/H(+) antiporter YhaU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhaU</name>
        <name evidence="6" type="ORF">B7C42_06940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40974">
        <property type="protein sequence ID" value="OXR40974"/>
        <property type="gene ID" value="B7C42_06940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="14"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="392" mass="40092" checksum="48423C5AB833F976" modified="2017-10-25" version="1">MESTALALFELGAVLFALGVLGRVAGRFGMSPIPLYLLGGLAFGDGGVLTVKAASEFGHLAGEIGVVLLLLLLGLEYTAPELVSGMRKSWLAGLLDIVLNATPGAVVALLLGWGPTGAITLAGVTYISSSGIAAKVLNDLGRLGNRETPVVLSVLVFEDLAMAIYLPILTTILAGVGWMAGLRSLALALLVIAIVLVIALRYGRFVSAIVDSKDREVFLLQLLGAALLVAGIASGLNVSAAVGAFLLGIAISGSTAQSAAKLLEPLRDLFAAIFFVAFGLNTDPQKIPQVLGWAVLLAVITTLTKIGTGWFAAKRQGIGRLGRARAGAALVARGEFSIVIAGLAVSVGAVPGKLAALASAYVLLMAILGPVAARVVEPAVRSMQRRFAPAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX28</accession>
    <name>A0A231GX28_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41167">
        <property type="protein sequence ID" value="OXR41167"/>
        <property type="gene ID" value="B7C42_06763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045425">
        <property type="entry name" value="DUF6508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20118">
        <property type="entry name" value="DUF6508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="141" mass="15683" checksum="CDA36520E7B53EB9" modified="2017-10-25" version="1">MTQANPMTVESAEAALARLTAHDRGVLTDLVCRVDKAASGTTAARSRKAPVLDEVVRFLVDRQLLLTHFNWGAWEEGQQAIQRRDRATLATCTAQQCLQYLTLLVRADRFTEGTLASAFESGLMQALLHRLHQHTYPHAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX65</accession>
    <name>A0A231GX65_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase NlhH</fullName>
            <ecNumber evidence="2">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nlhH_5</name>
        <name evidence="2" type="ORF">B7C42_06621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41223">
        <property type="protein sequence ID" value="OXR41223"/>
        <property type="gene ID" value="B7C42_06621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="125"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="355" mass="38207" checksum="0A83DA496A8AF98D" modified="2017-10-25" version="1">MASITSADTVPLHPVALSTAERLQRALFIALGRLPRPVLSRVAPPSVNAAGDEMAPEIAAIMKVAQQAGADFSDGSVADAREFVEAEGRIYAETFPRFAIEEDLELGNGLRATRYRAGAQSRGVVLFFHGGGFVLGSRTSYDGPARLIALRGGVDVVSVEYRLAPEDPFPAAVEDAMTAWRHVVAQAPVWGHTAERIVLLGDSAGANLCAVLTHQLRGSAVQPALQVLMYPVTDLTTERDSHREFRDNPALTTKQIQWFSDHYVPRHADRADPRVSPLLYDDFTGLPPALVTVAGFDPLRDEAIAYAGRLRDAGVPTRLLRESGLVHGYISMTKISPASRAAVARVTDAIARALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXF2</accession>
    <name>A0A231GXF2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41181">
        <property type="protein sequence ID" value="OXR41181"/>
        <property type="gene ID" value="B7C42_06777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019710">
        <property type="entry name" value="DUF4226"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10774">
        <property type="entry name" value="DUF4226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="397"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="495" mass="50271" checksum="FEF57820533D6089" modified="2017-10-25" version="1">MTSAETWQATVPEDTPEPVESGSETGEEQSTRPTPWSRPARQSPGRAGLPVSGSPAASDTAAATPVSDSIRPEATSGPRTVPAASSVPASPATTSPWAAGRTASVESATTPATDSAGPAPVRAAGSGLVTPRSTATAVGDGEAEDGGMSDPSALTSAMLPAMSMLPMLASALAGLGKNGSGAQQSGSGNGTGSNGSGGLTPEAQQALDALRKLKNTYGDEGKAPTDPETGGSGKQLDTRTGSGSSVGSGKTAAQIKAHQLFQRNAATAFNTLDNDLVDYMRRHAGKHTIDKKAVAQLLRDVDTALAQLGSAAYTKTGQLQVHRILTKALEQATRIVGGGSANSKEAASEINRLTKQYMYNLAGQQLSHSGGSGTKVGGTVGQWIEQALGVLAAAGVDTSRIDPQAIAIIIQYESGGNPSATNNWDSNAASGTPSIGLMQTISPTFNSYALPGHRNIYNPVDNIVAGVRYAISRYGSVSNVPGVVAVRNGQAYRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXF5</accession>
    <name>A0A231GXF5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Caffeyl-CoA reductase-Etf complex subunit CarC</fullName>
            <ecNumber evidence="5">1.3.1.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">carC_10</name>
        <name evidence="5" type="ORF">B7C42_06702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.108" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41304">
        <property type="protein sequence ID" value="OXR41304"/>
        <property type="gene ID" value="B7C42_06702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="213"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="355" mass="37678" checksum="781644D88D7CE6F3" modified="2017-10-25" version="1">MHWELSEEQELFAASLREWLTAKFPTEVVRKLQSGEDPDRFTDALVKEGWWGVGYSEEVSGQGGGVLELALAAREFGRAAVPDSRWLAAALVAPSLTGQELGDQLAGAKRFTLAIRADRIPTFEPLVAQDGSLTGTVRHVVGARGTDVFVVPVKGPEGLGLARVSAADAVIGPDRLLDRSRDAATVEFTGAPILEAVPTDESSLSRTTTLAGVLVAADALGSAERMLDLAVEYSKQRKQFGQFIGSFQAVKHAAAQMLVTVEASYSTALYAAAALDAGIDAAATIAAVAKAQVTGTVADLAESALTVHGAIGYTWEHDLHLFYKRAKLDRTLFGPPAAWNERIAAVLLDEPVRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXT0</accession>
    <name>A0A231GXT0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic serine endoprotease DegP</fullName>
            <ecNumber evidence="4">3.4.21.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">degP</name>
        <name evidence="4" type="ORF">B7C42_06474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043081.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41331">
        <property type="protein sequence ID" value="OXR41331"/>
        <property type="gene ID" value="B7C42_06474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="416"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="524" mass="53872" checksum="5FC868B689D6D1B1" modified="2017-10-25" version="1">MVAQVEFANVTTESTPSASSDSAARGNLRPSDAPVLGPRPVYRPDIDKHTARAFRRPEGQAGSFAPHAQAVPAPRHDAPELVNRPPDAVLAEAFGRPAGSEELLQRDPEAGADTPDTSAPVDPWRDPAAAARLGDPAIHTPAPQPLPPGVKLGAREVLFGGKVAPKALAILGVAALIIGVLGGLVGRFTAENTGALTSRKIALQQESNTDKPHSQVAKVADAVLPSVVSIRETVGDNGALGSGVVIDGNGYIVTNNHVISMAAQDKSGRAKIQATFSDGTRAPAQLVGRDPKTDLAVLKVDVKNLTVARLGKSGDVQVGDDVLAIGSPLGLSKTVTSGIVSALHRAIQESPEAGDDTAGAFDAVQTDAAINHGNSGGALVDGEGRLIGINTAIRSESGGSVGLGFAIPVDLVQRVSQTLIRDGVMYHPWLGVSAKTKQVENDVMSGAAVADVVGNSPAAKAGIAEGDVIVKVGDRQVTEPAELTVAVQSHQIGETVNFQLIRDGRQVDVPVTLESDKNAPQAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY19</accession>
    <name>A0A231GY19_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41523">
        <property type="protein sequence ID" value="OXR41523"/>
        <property type="gene ID" value="B7C42_06415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="10882" checksum="2F8B5EB92D8ADC08" modified="2017-10-25" version="1">MAQDKRAVFRDLVDRVLDGDGRTPREQRAQAFANAGPLPLRELVDKVATRPTAVTDADFAAAAASGFGEDELVELVIAAAVGQSARQYDAGLAALAEATRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY21</accession>
    <name>A0A231GY21_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41496">
        <property type="protein sequence ID" value="OXR41496"/>
        <property type="gene ID" value="B7C42_06388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011251650" description="MlaD domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="37975" checksum="16650504B0F0F7CA" modified="2017-10-25" version="1">MTRRTANLRRICACALVAATLAASAAACGFQPADIPVPGTGVGGPTYRLRIEFADVLNLPQGAKVIANGVRIGQLTHITVVEPVPATGTAAARKGYVIADVAIRTSVRLPVGTTARLRQATPLGDVHIALTEPAHPTAGEIRPDATIPISDTRPQLPIEDILAQLATFVGSGAVHDIQNIVHTVNGIMPADPAVTARISDVLGADLNDLAAHTDSIHQLVSGIQATVDEGLLNHTSTWDPLLTPDGVQHTTDVIRAEIGVVFVLTALGPFAPSTTWLGPVLDSTTAAARAVVPMLFGSAPLDTGSPSNMTRLTNLLQSQIIPFAERGPKINLAGVTISPPPAPGLPPEEQTTRIVDTLRMIGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY46</accession>
    <name>A0A231GY46_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkane 1-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.15.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alkB_4</name>
        <name evidence="10" type="ORF">B7C42_06594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.3" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043027.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41451">
        <property type="protein sequence ID" value="OXR41451"/>
        <property type="gene ID" value="B7C42_06594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018685">
        <property type="term" value="F:alkane 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052869">
        <property type="term" value="F:arachidonic acid omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03512">
        <property type="entry name" value="Alkane-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033885">
        <property type="entry name" value="AlkB/XylM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38674">
        <property type="entry name" value="PTHR38674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="141"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="408" mass="46827" checksum="C1EBD1B5D2525DF8" modified="2017-10-25" version="1">MSTEAGTADGLLDSGWRDRKRYLWLWGLFAPTGLFIIGLPLIWGLNELGWHTLAKVPFWLGPILIYLVIPAADLFFGADGENPPDEVMEYLENDRYYRYLTYIYLPFQYASLVMACYLITADNLSWLGIDGGLTVVDKIGLALTVGMVGGIGINTAHELGHKKVHLERWLSRIALAQTFYGHFYIEHNRGHHVRVATPEDPASSRVGESFWAFWPRTVWGSLRSAWGLERARLERLGKRPWSLHNDVLSAWAMSLVLYAALVAGFGLEVLPYLVLQAVVGFSLLEAVNYLEHYGLLRQRTDRGRYERPTPRHSWNSDHLVTNIFLYHLQRHSDHHAYPTRRYQTLRSWDGAPNLPSGYASMIMLAYFPPLWRRVMDKRVVAHYDGDLTQANLQPSKRDKVLARYQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYA6</accession>
    <name>A0A231GYA6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41565">
        <property type="protein sequence ID" value="OXR41565"/>
        <property type="gene ID" value="B7C42_06458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="357" mass="36337" checksum="8916B72C5335191D" modified="2017-10-25" version="1">MSVALVLLPAAVVVAGYFLVVAPVEKTRAYCATMPDAIGLYVGSHVTVRGIPVGTVTALTPGPSSVRVDFRMAADHPPRGDVAATTLSDSLVADRDLAILFDGNAPTTWDPHRCITRTLTPKSITETLDAVSRVAGELDGKGDPAAATQIHDGVAALRAATAGTGPALNTLITELGAALRSPDAATRHLGDLIDAISALSQTLAVDWDDVKAAIGRLGPGFEFIDNSIMGLAIPIIDRVGQLLVWANSIVRPLGGPVLDGLEAAVPSLRMLAAGVGSLKEIITMIPPIVSAFGRAADPGPNEAALTYSAPKVALPPADSARVCAALNALTPGGCPDSGDHPATIGLAQLVSAAMGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYB9</accession>
    <name>A0A231GYB9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gabD2_7</name>
        <name evidence="8" type="ORF">B7C42_06413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41521">
        <property type="protein sequence ID" value="OXR41521"/>
        <property type="gene ID" value="B7C42_06413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="7">
        <location>
            <begin position="15"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="511" mass="55256" checksum="D90F755565B9F56A" modified="2017-10-25" version="1">MAIVHPLPTSEGDRRTLALDSPVDRRRIGELEVDTTAEVQSAVARARAAQPAWAARSIAERAEILRGAVGVIVARRAEIAETIRTETGKPEAEALGVEIVPACDFLNYWTGRARRDLRSHRQRLHGYLKPFKKLYMQYQPLGVVGVVTPWNAPFVLSLNPVVQALVAGNTVVFKPSEVTPRSGEWVARVLHEAGVPKDVVQVLHGDGETGAALVDSEIDKVCFTGSVGTGRKIAAACATRLLPCTLELGGKDAMIVCADADLERAAAGAVYLSMFNTGQVCMSVERIYVVDSVADEFIRLVTEKAAAVTYGPGDTDMGPLFWDRQRDIVIRHIDDAKAKGADIVVGGAADTGDGLYFQPTVVVGVHHDMELMTEETFGPVTAIMRVRDEDEAIRLANDCKYGLSGSVFTKDAAKARRIAAQLTTGSVVHNDAAVIYGVPEAPFGGRKDSGVGQVNGPGALRGFTHAQPVLIDRWQPKGESIWYPYSEKTIRSLDGLIRYGFGNKIMRKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYX3</accession>
    <name>A0A231GYX3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moeA1</name>
        <name evidence="9" type="ORF">B7C42_06114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780806.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41772">
        <property type="protein sequence ID" value="OXR41772"/>
        <property type="gene ID" value="B7C42_06114"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="187"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="44458" checksum="BA69269AF7514E8F" modified="2017-10-25" version="1">MRSVEDQQIKVTAAAVAPRPVRVAISEAQGLLCAEDVVTERPLPGFDQAAIDGYAVRSVDVQGAGADIRTEDGDPIDLTLPVVGEVAAGSRQPIRLQPRQSVRIDTGAPLPTLADAVLPLDFTDGGRARIKIYEPVRSGDYVRRIGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRDKVLVHPRPRLSVISIGGELVDIDRTPGPGQVYDVNSYALAAAARDAGADVNRVGIVSADPKRLRDVVEGQLVRSEVVVIAGAVGGWASDQIREALEGLGELTIDRVAMHPGSVQGFGRLGRDEVPTFLLPSNPVGALVVFEIMVRPLIRIALGRRHPMRRVVRARTIMPITSMEGRRGYLRAQLMRDEQTGEYLVQPLGVNGSSHLLSTLAEANSLIVIDPEVTDIRTGDEVQVAFLAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYY6</accession>
    <name>A0A231GYY6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41826">
        <property type="protein sequence ID" value="OXR41826"/>
        <property type="gene ID" value="B7C42_06168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375769" evidence="1">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="32684" checksum="7EFFD1CC0AD340C7" modified="2017-10-25" version="1">MGRRSALALLAGLPLLVPGTARAQSALPGVGADPQRAPTRYTMAAFRADSDSTVAVYESVDGTRFTPVAEHAFTPRTGLARDPSVMLHTDGWYYLTYTTAPDATSIGLARSRDRIAWTEITPAPMLVPGRPEGTWAPEWYVDAAGRVGIIASLTWGHGFTPHLLLPVGAGLSTWAPPIPLVGVGPSGPGSLGFIDTQLVRWSGRVYAFAKNEDTKLVELAVADHPLGPYTFVAKGDWAGWGGPREGPSVVPLPDGGHRIYLDAYTEGRYLYSDSYDGFRTWSAPTELPGLSGVVRHGTVLAEFGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYZ0</accession>
    <name>A0A231GYZ0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780755.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41808">
        <property type="protein sequence ID" value="OXR41808"/>
        <property type="gene ID" value="B7C42_06150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12238" checksum="992B24752C4BC9E2" modified="2017-10-25" version="1">MNIAYYIVGTAAALWIGFSGYSLFTKSEFVVEPLHRYGVPRSWWNWLALAKSAGALGLVAGFIVPAIGVAAAVGLILYFLGAMATTVRAHSYGTTIFPALYLLPAAATLALQLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ05</accession>
    <name>A0A231GZ05_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F420H(2)-dependent quinone reductase</fullName>
            <ecNumber evidence="4">1.1.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41844">
        <property type="protein sequence ID" value="OXR41844"/>
        <property type="gene ID" value="B7C42_06186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="3">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="40835" checksum="E8456648C98E2B2D" modified="2017-10-25" version="1">MIARNVLPDIAHPDVDTVLIVRSAAEEVFADLERGSWPKELISCTAFVSTDGEKNVTYTQWRNGAAGREYLTGFAGIEAVEYRLYRSSVGVNPPVPGCIVILDVEFDGPDPDRQQRWVDTVFDAMAGETDPHPGGISGHFHVSTDGTRVLPYAEWTTADAHRDAIERSGQSMIGAGSGWRRVKEFPGVTDSGFTRYHLLHSLSESSAPEPDDVHDSPTDWVADHVRDYVETDGQSGHLYQGRPSLLLTTRGRKSGKLRRTALIYGEDDDRYVLVASNAGSPTHPAWYLNLLADPDVTIQVGAEKFTARARPATAEEKPPLWHLMTAIFPLYDTYQAKTHREIPLVIIERRPEGLIEPEPAPPGLETSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ36</accession>
    <name>A0A231GZ36_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyketide synthase PksJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pksJ</name>
        <name evidence="8" type="ORF">B7C42_06123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41781">
        <property type="protein sequence ID" value="OXR41781"/>
        <property type="gene ID" value="B7C42_06123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="725"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2352"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2433"/>
            <end position="2535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2445"/>
            <end position="2459"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="760"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="2552" mass="270938" checksum="4488BACDA6AE0D16" modified="2017-10-25" version="1">MQADFLPGVLAIATDFRRAPVQRYLRAREEYRPGASGPAVAALIALIHRYSEHAEVTLGVIAPEDDSPIPLRIAVEPDRTAEALAAEVDAARSRLVAARAGFDIDELIGKLCPTPVFDRHPLFQIAYCELTGDHDPDAAEDALEAVVGCDLVFVDDRGAGELRCEYDAELFEPRTVRRLLAQWALLIDAFTAHPDTELAALPMLPEDDRAALDGWSAGPPVARPATTLHALVAERAARRPHSPAVISEAGTLSYGELDDRAARAAGYLSAVGVRPRQIVALCLRRSPRVPVLALGVMKAGAAYLPLDPADPDARLATILADSGASVVLCDDAGIAGRLSAEGVTAIDLDEVWQDLEQVEPAPARVGAPTDLAYVIYTSGSTGRPKGVLIEHAAICNRLLHDAIRIDESDRVLQKTPLTFDVSVWDLFYPLVHGAQSVLCDAEGHRDSRYLLETIRAQKITVAHFVPSMLRTWLAEPGVEACTSLRYVTTSGEALPADVAAEFHRLLPDTALHNYYGPTEAAVDVTCEQVLPGAAVTLGRPIENVRALVLDAAGQPVPVGVPGQLHLAGVCLARGYVDPADEIGRFVADRRTGERLYATGDRVRWLPDGRLEYLGRADHQLKLRGLRIEAGEVEAALRTADEVREAVVTVFGDDPERSELVGYVSPADDAAVDADALREHARALLPAYMVPARIVVLEDFPRNAAGKIDRRSLPAPVVTVRGTTTASANELSDAIAAVWARVLECDSVPATANFFDLGGNSLLVARVHVALEEALGISIARTDLFRYPTVAALAAALAGSVAARDVADEAGDHSGPFAVIGMAVRVPGAADLDEFWDVIADARTTMTELDDEQLRAAGESAERIAAPNYVRTAAVLDDIAGFDADYFGFTAREAQVTDPQHRLLLECAVEALEHAGYGGAPQRPRTGVFVGGLPSSYFHRYFADDFTRLPSTQHYQIKVGNEPDFLPTSIAYRLDLHGPAVTVQSACSTSLVAVHLACQSIGRGECEIAVAGGVAVRVPDRVGYLHQEGMVASPDGHCRAFDEQAGGTIFGNGAGVVVLKRLDDAVRDGDRIFAVVRGTAINNDGAAKVGFTAPSVDGQVEVIRRAHRVAGVAPAEIGYVEAHGTATPMGDPMEIAALTEAFGGPREDRCDVGSVKANIGHLDTAAGVAGFVKAVLALDHAVLPGLANLERPSSRIPWSETPFQVSPRPRPWPSDRPRVATVSAFGIGGTNAHAVLEAAPPRAATAVPEGWTGLFRLSARSDAALRDLAHRYLDRLNDDTAIEDICYTTGFGREQHERRLAAVISSLPELRAALTAYLRGEPAAALFTEAEQDADRRLCLVLGDAPEAGVDAFLDLYAEDSVVRTARAEVTDALGGTEPTGVQADLARLYVLVQVWRACGLQWDAVIGYGTGEYVAAAISGVVDLATALRYAAAATPLTTGGDRRELRLVSQASDVESCVTAAGCDRMLVLGRRSDERARLRLAADRQGVHTVLAADGPHDFQRTFLIAAAKLYAVGMDICPTPWGPFAVGRRIPLPTYAFQRSRFWVEPERALRRTVGAAEDTGLPGRPVDLPLSEEIRYERSFACDSPSYVTDHRLFGTAVVPGASHIAMVLAAAAHHLDGPYALRDTLFLNPFAVSDGGSRRAQLVLRPNGSGWDVTLVAEEESGAGAAWPALFRTALDSAVAESDSTFGDAARGDVLARCPQELSGLEFYRDVWVPGLDTGNSFHWIETIWRGDNEALCLTTRPEGVEIGPEPLHAGLVEAAFQVLNSCWKYDNALLRAQENIYVPFSIDRYYFSGRRTAGPLWIHARLAGGHGAGDEAFTAHIRMYDVTGELVVAVDGFESRRISRAQVERALAHKTADTTHEQHWQRTEATGAGAEPVSLLVVDDEPDRLSRFARVLRERAIPAVTVLIGAEVPPASGITRHAVTDAETGSWPAELAAADRRGFVDLRGLSSTDGESAQFVGEAAQRCAAAVRPLPALASERVRVWWPTRGAQPVTCDTDVTEPAATMLWGIATVVRREYPELRCSTVDLDDDTDSSLVRLAAEIHRWSPEMRIAHRGANRYVARLRRAQPGTDVRIRSDRSYLVTGGLRGIGPRVARLLAEQGAGHLVLVGRTAPDPETAQLLDELRDGGCPVTVHTADIGTESLAGVIAAAPHPLGGIVHAAGVLDDATIAGLDAGRFEKVLAPKVGGIRSLRDIIGAETDFVVCFSSLTATVGAGGQANYAAANAYLDGYASVLRAQGIPATSIAWGPWGEIGMAARLDAEERERSRLRGYRPLSPEQGLRLLAGNLVAAGPTVVAADLDWPKLAAAAGGDPWYGSVAATPAAAGPAASLRERVLAAARTDRPALVRDLTATEVKAVLGLDDGHLIDPEEGFTQLGMDSLAVVELRSRLQDGFGLALPATFGFDYPTIEKAAEYLSATLAAEKADTPDGTVATAAPRVRPQQPTTQDGPPHPAATSPDGSVPTESYSGAAASSEPAAAGSAPPVSGPAASGSPAPVIAAASPAGPASAESPPASSARPAASPPEDPIAAELALLEAALHSDAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ93</accession>
    <name>A0A231GZ93_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigJ_8</name>
        <name evidence="8" type="ORF">B7C42_05904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41920">
        <property type="protein sequence ID" value="OXR41920"/>
        <property type="gene ID" value="B7C42_05904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="306" mass="33654" checksum="E162BAC53A7521AC" modified="2017-10-25" version="1">MTSTDEHTERFVHLRPLLFTIAYEILGSATEADDVLQDSYLRWRRVDLATVRDTKSYLAQLVTRQALNALRASVSRREEYVGPWLPEPLLLTDGDASSDVVLTESVSMGMLIVLETLTPIERAVFVLREVFGFDYDEIASATGKSVGAVHQTARRARNHVHARRKRSGPVDTVRTAAVTERFITAATTGDMEGLLSLLAPDITWTTDSGGKVTALPELVMVGAERVGAILMAVFRYALRRPEVRIETVNCNGQPALACYIGDKLEAVLAFDIAEDRIVGGYGIRNPDKLAALDIPRAISRTETPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZA1</accession>
    <name>A0A231GZA1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="4">G6PD</shortName>
            <ecNumber evidence="4">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">zwf</name>
        <name evidence="8" type="ORF">B7C42_05912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41928">
        <property type="protein sequence ID" value="OXR41928"/>
        <property type="gene ID" value="B7C42_05912"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="7">
        <location>
            <begin position="178"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="463" mass="50754" checksum="93ADC00A77B3BD4A" modified="2017-10-25" version="1">MIRRLVIFGGTGDLAGRYLLPGLAALHETGRLEPGFEVVCADRKGRDDEQFREWAAAQLDRYAPAASADTQRAILDAARYQQADIGDPAQVAEAIGGAGAVAVYLALPPALFSTAIRTLDAARLPSGSRLVFEKPFGEDLTSAQELNTLLADLVPEQAVFRVDHFLAMTTVQNLLGSRLANRVLESLWNSAHIAEVEIVWEETLTLEDRAGYYDQVGALEDMVQNHLLQLLCLVAMEPPITLSERDLRDRKVDVLRSIRTLTDDDIPRRTRRAWYTAGVIGDRHVPSYTDEPGVDPQRRTETFTEVRLAIGNWRWAGTDFVLRTGKALAADRKEVAIHFRPVPHMPFGHHGTAAPNVLRFGLEPENLTLALTAIGAAAGTLVPLSMNAAIPPPDLPAYGRLLLDVLLGNPALSIRGDEAEESWRVVTPIISAWSRDLVPLEDYPAGSAGPGTSHTPNRKDRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZA9</accession>
    <name>A0A231GZA9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779012.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41943">
        <property type="protein sequence ID" value="OXR41943"/>
        <property type="gene ID" value="B7C42_05927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="1">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="225" mass="25288" checksum="94D5BBF755CA8867" modified="2017-10-25" version="1">MDNEHDHPAAETAPADPGSVPRVGSFRFWFATRRWEWSEEVYRMHGYIPGSVVPTTELLLSHKHPDDRDDVAARIARAADMGESFSSRHRFIDTAGRVHNVMVVADRLYDEAGAVTGTAGFYIDLTETLAESERETLSAALPDVIEHRAVIEQAKGVLMRMYRVSAEQAFKILSWRSQETNTKLRDLAAQLMAELPTLPDAEPQTLTAFDHLLLTVHTRIPGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZN8</accession>
    <name>A0A231GZN8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42073">
        <property type="protein sequence ID" value="OXR42073"/>
        <property type="gene ID" value="B7C42_05672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="203" mass="22081" checksum="218F81CBBF0BA51A" modified="2017-10-25" version="1">MKTSTEMLRELDPQALGPSAFCAALFSYLEHEGATMYDETVTQLEHGLQSAALAEQEGYGPDLQIAALLHDIGHLMLSEHDARDDFLATDLQHEIVGAHLVTQWFGAEVGGPIALHVPAKRYLVATDPGYADGLSAASIRSLEVQGGPMSTEEVQTFETLPYHAEAVLVRRWDDRAKVAGLEVAPLQHWRPAIELLISAAADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0V7</accession>
    <name>A0A231H0V7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor ComR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">comR_5</name>
        <name evidence="5" type="ORF">B7C42_05249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42473">
        <property type="protein sequence ID" value="OXR42473"/>
        <property type="gene ID" value="B7C42_05249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="213" mass="23699" checksum="45156B12D2C770B6" modified="2017-10-25" version="1">MLDGMTSPWSVRAARERSETDRHRALLDAAAEVFIERGYAATTVAAITARAGVSRATMYVYFASKDEIFHALATRVRDEFLAAQEPDLTDSDPREMLRATIESFAEAVLHAGPLLRLIEERGTVDPRIGELAAEISERPIRRFTRYLDREHRAGTITPAAPVRVVAETVGYALTRGILDRRADPPPARARYLEQMRRIAETLLGLRPAAENSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0X2</accession>
    <name>A0A231H0X2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">NADH-quinone oxidoreductase subunit I</fullName>
                <ecNumber evidence="10">7.1.1.-</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">NADH dehydrogenase I subunit I</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">NDH-1 subunit I</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">NADH-quinone oxidoreductase subunit H</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">NADH dehydrogenase I subunit H</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="9">NDH-1 subunit H</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">nuoH</name>
        <name evidence="10" type="synonym">nuoI</name>
        <name evidence="14" type="ORF">B7C42_05269</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 11">Cell membrane</location>
            <topology evidence="9 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42493">
        <property type="protein sequence ID" value="OXR42493"/>
        <property type="gene ID" value="B7C42_05269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="591"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXR42493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="640" mass="69114" checksum="0AA8219323EABBDB" modified="2017-10-25" version="1">MSEMSPAVLVAAPADLSAFGHDPWWLVVVKSIGIFVFLLLIPLLAVVIERKVVAWMQMRVGPNRVGPRGSLQSIADGVKMLLKEDIVPAMVDKPIYILAPIVALIPAVMAFAVIPLGPEVSIFGTRTPLQLTDMPVGVLYILAMTSIGVYGIVLAGWSSGSTYPLLGGLRSTAQVISYEIAMAACFAAVFLLAGTMSTSGIVDRQWGTWNVWLLLPSFLVYAVAMVGETNRAPFDLPEAEGELVGGFHTEYSSLKFAMFMMAEYINMGTVSALATTLFFGGWHAPFPLNLWDGANSGWWPLLWFTLKVWTFLFVFIWLRGTLPRLRYDQFMNLGWKLLIPVSLLWVMIVATLKVVQDNGHDVQTAGLVTAGVIISVGLLAIMLRAGRAGDNPAPETAGTQQFSDFPVPPMPDTAPAATKAGLLEPIGGFWVTFATMFKKKNTEFYPEEKVPTAPRYHGRHQLNRHPDGLEKCIGCELCAWACPADAIYVEGADNTDSERYSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTNEYELADDNRADLIYEKDRLLAPLGDGMIAPPHAAYPGATEQDYYLGAVPAAPGTDRDTGLGSTGIAVARQPGSDGPDLVSPDAAESAADVARQPAATAAQGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Y9</accession>
    <name>A0A231H0Y9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative oxidoreductase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_05310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42534">
        <property type="protein sequence ID" value="OXR42534"/>
        <property type="gene ID" value="B7C42_05310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="6">
        <location>
            <begin position="119"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="7">
        <location>
            <begin position="644"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="759" mass="83873" checksum="3894F2CD453F7559" modified="2017-10-25" version="1">MVDNASARRSPEPEFHPYDHPAAGWGAAKSVTRFLAREREGIDGPRAILKMNHENGGFDCPGCAWPDDMKGLHLDICENGIKHVAWEMTHKRVGREFFAAHTVSELSEWSEFELEDQGRLTEPMTYDPDTDRYVPISWPDAFELVGRTLRETDPNAAAFYTSGRLGNEATFLYQLMARELGTNNLPDCSNMCHEASGRALQAALGTGKGTVDLADWETTDALFILGVNAASNAPRMLTSLVEAHKRGARIVHVNPLVEAAARRAIIPHDFAQMATFRATPTSSLNLQPRIGGDMALIRGIAKAVLEESHSNPKAVDAEFIQRYTAGIDDYRAVCESTSWSDIERQSGVAVGDIRAAARIYTDADRSIVSWCLGVTQHEHGVDTVREIVNLLLLRGNLGREGAGPSPVRGHSNVQGNRTCGIDHRPTAEFLDRLARVCRIDPPRRHGLDTVATIDAMNAGRVRVFVGMGGNFALAAPDTAYTFAGLRRCDLTVQVSTKLNRSHLVHGARALILPCLGRTERDEQRGGLQETSVEDSMSMVHLSKGMKKPASPHLRSEPAIIAGIARAALPHSATPWEFYVEDYDRIRDTMAEVLDGFEDFNRRVRLPLGFRIRQPARELVFRTPTGRAEFSAAALPDLDRAPGTLTLATMRSHDQWNTTIYSDNDRYRGVRNLRTLIFMNADDMRERGLALFDEVDITSIARDGSTRMVRNYKVVPYDIPPGCAAGYMPDLNVLCAIGDYSTQSDQPIMKNLTVTVRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H123</accession>
    <name>A0A231H123_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1-deoxy-11-beta-hydroxypentalenate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.340</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ptlF_3</name>
        <name evidence="1" type="ORF">B7C42_05351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.340" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777355.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42574">
        <property type="protein sequence ID" value="OXR42574"/>
        <property type="gene ID" value="B7C42_05351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="28243" checksum="E722F9690EDCCD1E" modified="2017-10-25" version="1">MQVAQKVAIVTGGGGGIGGALAARLAAAGARVVVADLDEAAAKSVADAVAAEHPGACVSAGADVSDPEAIANLITLAEKTFGPVDLYFANAGIAGAVGLEVAEADWDRSFDVNVRAHIRAATQLVPQWLERGEGYFVSTASAAGLLTQIGSATYSVTKHAAVGFAEWLSVTYGDKGIRVSCLCPMGVDTPLLYAGRDSGDRLGEASTRAVTAAGEVLEPAQVADAVLAAIDTEQFLILPHPSVLEMYRRKGSDYDRWLAGMRRYQHSLLDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H174</accession>
    <name>A0A231H174_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42551">
        <property type="protein sequence ID" value="OXR42551"/>
        <property type="gene ID" value="B7C42_05328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="159" mass="17279" checksum="7BC4F465B0499581" modified="2017-10-25" version="1">MVRIGVTGHMDITDDTRRLVYGKITRLLARWDDVTGISCIARGADSVFAQAVLDSGGRLEVVIPSRNYREKKVEPDHAPVFDELSKRAEVVNVMPFDDTGPEAYGAANEAVVGTCDRLVAVWDGQPGKRSGTGSVVEFARARGVPVDVVWPEGARRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1B8</accession>
    <name>A0A231H1B8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoserine phosphatase 1</fullName>
            <ecNumber evidence="2">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pspA_3</name>
        <name evidence="2" type="ORF">B7C42_05414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778208.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42636">
        <property type="protein sequence ID" value="OXR42636"/>
        <property type="gene ID" value="B7C42_05414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022492">
        <property type="entry name" value="Phosphomutase_MSMEG4193_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03848">
        <property type="entry name" value="MSMEG_4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="26547" checksum="99BD515C3ED9BB21" modified="2017-10-25" version="1">MTVILLRHGVSTSNTARTLAGRSPGVELTERGTEQALAVAERLAPLPIEHIVHSPLLRCTRTVSPLADKLGLDPEPDERLLEVDYGEWTGRLLSELVKEPLWKVVQQHASGAVFPGGEGLAQVQYRAVAAVRAIDAELAERHGRDALWVACTHGDVIKSLLADAFGIHLDGFQRIVVEPASISVVRYTPAAPYVWRVNDTGSDLSALAAVAQPSEQRAGPVPGGEVGAASRADNGNIADPPDSGNERNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1C2</accession>
    <name>A0A231H1C2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase LiaS</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">liaS_5</name>
        <name evidence="4" type="ORF">B7C42_05389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42611">
        <property type="protein sequence ID" value="OXR42611"/>
        <property type="gene ID" value="B7C42_05389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="478" mass="49631" checksum="9F49E03D01895919" modified="2017-10-25" version="1">MSPSPWALLRRTPRQPGADSAAGPPGGELRAVRRSLTRQSVAVAVVAALVDAVVFALSGIFAVAPGPASGILVAIVAADLAFAAPPATAAVVAVVQVAIRLAVTVLLHRHGLPVRVADVGFLVAGYRAGAWLSGRSSLVTVPVLVLGACGAPLIAGGAPAADWRLLLTSAISGGVVPWLVGRYTAGRGAYIAELEQRERLARQQQRTALERALTDEREAIARDLHDVISHHVSAIGIHAGAARLALHGSGAATAAATRSLSAVESESRAAMVDLRRQLDLLHGREDAARQPGMADIDDLVDRVRGAGLELTVTTSGAELPRSLDITVYRIVQELLTNALRHGAGSARLTVRNDGTGVEIEQSNPLTGEQVSITSAPCVPAARATAPLDSAATPHGADAVHIPVSQRATTPATARFRSGRRAPMRERGPGTRAAPEATTGVHRGLDGIRRRAELFGGRVDHGVADGHWRVLVRLPGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1N5</accession>
    <name>A0A231H1N5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42763">
        <property type="protein sequence ID" value="OXR42763"/>
        <property type="gene ID" value="B7C42_05101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007427">
        <property type="entry name" value="DUF475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04332">
        <property type="entry name" value="DUF475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="427" mass="45304" checksum="A1EDDA503751C3F1" modified="2017-10-25" version="1">MTREVIPPAGVELTKGIGMFVRVFALSFLVAAASLVVAVLYGGPEAVVLVAALGVLEVSLSFDNAVVNASVLQRMSAFWQRIFLTVGMVIAVFGMRLVFPLVVVAIGAHLDPIEALRLAMNPPAGGAPFFPDGRPSYETLLNDANPKIAAFGGMFLLLLFLNYICAQREVTWLSWLERPLARIGRFSMFTVVIALIALVLTAGVLAPNTKADVVMVSGALGMATYFLVDGLGAHFENEQPGQGPSRAALLTGRAAFFGFVYLEVLDASFSFDGVIGAFAISADPIVIALGLGLIGAMFVRSITVYLVRRGTLAEYIYLEHGAHWAIGALAAILLVSTGHHLNEVVTGLLGVGIIAAAYLSSIVHNRRHRTPAATETELERLSLGGDELTLRGDTGTLSSLDGGLPIDRVTLRGDALPARDKLNTDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H251</accession>
    <name>A0A231H251_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tatA_2</name>
        <name evidence="7" type="synonym">tatA</name>
        <name evidence="9" type="ORF">B7C42_04804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778353.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42918">
        <property type="protein sequence ID" value="OXR42918"/>
        <property type="gene ID" value="B7C42_04804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="96" mass="9876" checksum="41710FCA21DEF30B" modified="2017-10-25" version="1">MGSLSPTHWLIIALVILLLFGAKRLPDAARGLGRSLRIFKSEMSEMQSEGSANAGSANTGSANASGTTPQSAPAAELPPAQPVNPAPQADKDRHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H282</accession>
    <name>A0A231H282_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pknB_4</name>
        <name evidence="10" type="ORF">B7C42_04839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42953">
        <property type="protein sequence ID" value="OXR42953"/>
        <property type="gene ID" value="B7C42_04839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="545" mass="55069" checksum="F165599B0716748C" modified="2017-10-25" version="1">MTSDRLIAGRYRLADPIGSGAMGVVWRASDVRLRRTVAVKQLLLAPGLTKAQALEAKMRAMREGRIAARLHHQNAVTVFDVAEEDGQPWLVMEYVDAQSLAALMRDKGPLEPREVARIGAKVAAALAAAHDAGIVHRDVKPANILVADNGTVKITDFGISRAVGDVTVTSTGFLAGTPAYLSPEIARGEDPEPSSDVFALGSTLYAAVEGAPPFGEGDNPLAVLHSVVSAKVPEPKRAESLGPVLMSLLAADSADRPTMREAQQALEAVADGRPAALVPAATKVLPQPGADAAATTVLSAPEQTPAAPAPAGAASTARTPAPQPKPGPLRDRRIWAAAAAAVLVLAVIIGLVATSGSDDNHSTAAGNGTTSAPEQPSATAFAPPGAATPDAPGGSSANGAGGSASLGSPVPNGQTPPPAPSGAPAPGTSGTRTPPSGTSAPYGPAQPADVASFISGYYGMLPGNTSGAWAELAPSYQSQTGGYAQYSNFWSTVSSVRVGGVTQSGPGRAVAALTYTLKNGTVTSESRWFTVDTATGRMLITASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2J9</accession>
    <name>A0A231H2J9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malonyl-[acyl-carrier protein] O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.197</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bioC_2</name>
        <name evidence="2" type="ORF">B7C42_04962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.197" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43076">
        <property type="protein sequence ID" value="OXR43076"/>
        <property type="gene ID" value="B7C42_04962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102130">
        <property type="term" value="F:malonyl-CoA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="57"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="25923" checksum="17E6C4461CC63BC3" modified="2017-10-25" version="1">MPTFADFDRRHYRTVDVAIGYDGWAPTYDQTVMDDMDLALLNRLHRPNWERVRRAADLGCGTGRTGHWLRERGVAHIDGVDLSEGMLSVARDRGAHTTLTHADVRDSGLPSGTYDLVVCSLIDEHLPDLTPLYAEARRLAAPGGAFVLVSYHPQFLMVTGMPTHYTGESGEPLAIDTHLHMFSEHVTAGNDAGWRLEEAAEALVEEAWLAAKPKWKDLLGHPFSMALAWTLPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Z0</accession>
    <name>A0A231H2Z0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acryloyl-CoA reductase (NADH)</fullName>
            <ecNumber evidence="3">1.3.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acrC_5</name>
        <name evidence="3" type="ORF">B7C42_04590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.95" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43168">
        <property type="protein sequence ID" value="OXR43168"/>
        <property type="gene ID" value="B7C42_04590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="195"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="351" mass="36532" checksum="C0EA8E73D45641D9" modified="2017-10-25" version="1">MSEVVRRDPDLVRLVTEFFSQTFTPDVVTTVENAGFSPGLWSSVEQLGLPLIGIEEDLGGSGGSLLDLLAVGHGAGEYAVPLPLAETSLAAWLLTCAGAPVEPGPMTVITDSTRLRLDGNRLSGTAGDVAWARGATRVVAIVEDGSGSSRVVSVNAADLDIEAGTDLAGMPRDRISAAHVEVQTWAGDVTADALLLRGALLRSAQMAGAMTAAFDLTKRYVEQRVQFGQPIGAFQSVQTHIVELAQASASTTLSVDRAGAAALRGPASFEIVAAKSLANRNAGLAVRAAHQAHGAIGMTREYSLQLLSRRLQGWRGDFGDEMTLNMRLGAAMARERGIAAAVTSVGSTVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3G1</accession>
    <name>A0A231H3G1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional cytochrome P450/NADPH--P450 reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cypB</name>
        <name evidence="2" type="ORF">B7C42_04271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43404">
        <property type="protein sequence ID" value="OXR43404"/>
        <property type="gene ID" value="B7C42_04271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="53316" checksum="6F3D9ECB74EC185F" modified="2017-10-25" version="1">MHREPDPHGDTDSRSPADPARPTPAPGRAAHRLTGPRAAAAVADLGLASVAAGVIARRRGMMAVLERLGADDRAVHRMHRLRREFGSGPVELVLPGRRVVVPLDPADIPRILDGAPSPFHPANREKIAALRTFQPHGVLISEGAARDQRRRLNEQALDTDRPLHHLADPFAGVVADAAREQIRTAIQRGGLDAAHFTTDWWRLVRRIVLGRRAREDDSITDRLWRLRAAGNWSYFARPHRRLRERFYEQLYDYVQTAETDSLAGALTQLPAPGAVDPVGQIPHWLFAFDAAGMATIRALAVLSTHPEQLARARLDAQEPERAMPRPYLRACVLESVRLWPTTPAILRDTTEDTEWGHGDDRFTVAAGAALLIPVPAFHRDADTLPFAHAFEPDIWLDGRAERYPQLVPFSAGPARCPGRDLVLFLTTSLLAHLIDELDLELRSHPRPIPGAALPITFDNFRIDFTARARALQAAQSPSSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3P2</accession>
    <name>A0A231H3P2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43451">
        <property type="protein sequence ID" value="OXR43451"/>
        <property type="gene ID" value="B7C42_04318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="146" mass="15582" checksum="BE30437FD2FBD0EC" modified="2017-10-25" version="1">MRAQIHAITLGVRDLEVSLRFYRALGLESPGIIGTEFRPDAANPGGAVVMFPLGNGVTLALYGRDDLAEDAGIPPERMHGSAMSLGWFVDSDAEAERVLDLAGASGGTVVQPARPRPWGIYAGYFADPDAHLWEVVHFAQPLAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3S8</accession>
    <name>A0A231H3S8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043566.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43396">
        <property type="protein sequence ID" value="OXR43396"/>
        <property type="gene ID" value="B7C42_04263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="74"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="253" mass="27926" checksum="BFDF6FDBA9B3B8A1" modified="2017-10-25" version="1">MNAPISTADPVALPPSVEFDNRDAVYEYYRTHRAPRTRARLFYAITAYRKRPAVHYAEGARAAIRQLIRDNRRMIIAINHVSVEDPRTVAAFAWRSVFRPRIGHIRVLAKDELFTEPGQRSRIDVMGAIPVFRGKDHGARAAYAAGQQLMDVCVGRMVDGDDLALFPEGTCNETDPSRVQTIGTGIGHIAARARNAGAAPVFVFLGLTYGPGGRATFYLDEPLPDFPERPAQITRVVGTRMQRALDGAIAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H488</accession>
    <name>A0A231H488_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeS cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sufB</name>
        <name evidence="4" type="ORF">B7C42_04508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778879.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43640">
        <property type="protein sequence ID" value="OXR43640"/>
        <property type="gene ID" value="B7C42_04508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="3">
        <location>
            <begin position="153"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="486" mass="53780" checksum="579A7B883E422AA4" modified="2017-10-25" version="1">MTSTTAASRESDAPQNQPLTQEETIASLGTYGYGWADSDIAGASAKRGLSEDVVRDISAKKNEPEWMLDARLKALRIFDRKPMPSWGSNLEGIDFDNIKYFVRSTEKQAESWEDLPEDIKNTYDKLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGVIFLDTDTGLREHPEIFQRYFGSVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIVDEGAYVHYVEGCTAPIYKSDSLHSAVVEIIVKKGGRCRYTTIQNWSNNVYNLVTKRAKAEAGATMEWIDGNIGSKVTMKYPAVWMTGEYAKGEVLSVAFAGEGQHQDTGSKMLHLAPHTSSTIVSKSVARGGGRASYRGLVQVNKGAHGSKSTVKCDALLVDTISRSDTYPYVDIREDDVTMGHEATVSKVSEDQLFYLMSRGMTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4F0</accession>
    <name>A0A231H4F0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multiple sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msmE</name>
        <name evidence="2" type="ORF">B7C42_03943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43708">
        <property type="protein sequence ID" value="OXR43708"/>
        <property type="gene ID" value="B7C42_03943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012398506" evidence="1">
        <location>
            <begin position="27"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="417" mass="44481" checksum="35A7A34289758A2B" modified="2017-10-25" version="1">MTLVSGRPRVPFALAALLVVLSTAVAACGFRGRSADDSDPNALALLVPAYSDATRAEWSTIIANFRAQNPAITIHLQVESWDSINEVVRTDLQSVTTTPDILGIDAYSAYATDDMLYAATDIADPAVLHDIDPGFARNASIDGTQWALPLFASTRTLFYNTDLFARAGIPGPPRTWSELREDAHRIQALGGGISGYGLPLGSEEAQGETSIWTFGAGGSWSDGTTLTVDTDANREGVREMAALAAAGDTQPNPGSTDRKDVINAFIQGRIAMIEGLPPVLGMIDRQNPALRYATAPSPTKTGAPVTLGVADHLMAFRKHGNKQAAIRQFLNFFYSPAVYSDFVRAEHFIPITASGARALAHDPVTETFAATLPVARFYPSADPNWAAVQGAIRQQMGTVTQGADPAEVLRRIARAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4G8</accession>
    <name>A0A231H4G8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43737">
        <property type="protein sequence ID" value="OXR43737"/>
        <property type="gene ID" value="B7C42_03972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="340" mass="38955" checksum="B3FACA6DD055F419" modified="2017-10-25" version="1">MAQHTENFAGDASDGRERVAQRLLRSSAEHFYDADIDIDWEQPWQPDKAWLPEHRISLYGTPLWDRLTPEQRIKLGKHELVSLLSFGIVAEGLLSKYLLRIVARDPTSQHAMYALTELSEEARHSIMFARLIDKTGIPPYRPVALNRMQLRVAEHFPIGPVVYAGTLLIEEILDRGQREAMADSEIQPHVRQLMRIHVLEEARHIGFARDALARGMARRSRWQRLPHQLLLAYFALVLYPMLVNPQVYRAVGIDPRRGFAAAFTGPQYRRTMSFLSEPMLRYFDEVGMLDGAAVHTLWRLTRSLPDDLCRRSVNGPAPQANPSFRPARPRWSARPAAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4L9</accession>
    <name>A0A231H4L9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gpmA_1</name>
        <name evidence="4" type="synonym">gpmA</name>
        <name evidence="6" type="ORF">B7C42_04003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43768">
        <property type="protein sequence ID" value="OXR43768"/>
        <property type="gene ID" value="B7C42_04003"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR43768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="248" mass="27319" checksum="DB667780088B9F2C" modified="2017-10-25" version="1">MTCMTYTLVLLRHGESEWNALNLFTGWVDVHLTDKGVAEGKRAGELLAEHGILPDIVYTSLLRRAISTANIALDAADRHWIPVVRDWRLNERHYGALQGKNKAQIRDQYGDDQFMMWRRSYDTPPPPIEADSEYSQNGDARYAGIDVPATECLKDVVARMVPYWESTISRELVAGKTVLVAAHGNSLRALVKHLDGISDEDIAGLNIPTGIPLRYELDENLRPIGPAEYLDPEAAAAGAAAVASQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4S1</accession>
    <name>A0A231H4S1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2-succinylbenzoate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menE_1</name>
        <name evidence="3" type="ORF">B7C42_04065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.26" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43830">
        <property type="protein sequence ID" value="OXR43830"/>
        <property type="gene ID" value="B7C42_04065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="47"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="287"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="377" mass="39091" checksum="D7439CFDFDD255A3" modified="2017-10-25" version="1">MPTGAAVGDVLPHLREALEGNGPAWLPIPTGDRRESHRLSSALRPGEEIEDDVALVVTTSGTTGVPKGAMLTSAALRASGDATHERLGGPGQWLLALPTHHIAGVQVLLRSIQAGTEPVVLDVSGGFLPGGLATAVSAMTGPRRYTSLVPTQLIKALDDPVGAQALAALDAVLVGGAATPKPVLDRARAAGINVVRTYGMSETCGGCVYEGVPLAGAKVRIEDGRVLLGGAMLAKGYRGIPDHPAFAEPGWFRTEDAGTFDDGVLTITGRLDEAIMTGGLLVIPQVVEAVLATHPAINEAVVLGLPDPRLGQRVAVAVVPNPGATLTLDELRAHVVAELDPIAAPRELAILDEIPMRGPGKPNRVKLREHLLEQATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4T5</accession>
    <name>A0A231H4T5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781104.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43874">
        <property type="protein sequence ID" value="OXR43874"/>
        <property type="gene ID" value="B7C42_04113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="121"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="413" mass="44218" checksum="D77C611C01255735" modified="2017-10-25" version="1">MSRLVRYQLIAFAVIAVLGVVFVGAKYIHLDHMLGFGQYQVKVKAKTTANLSKGAEVTYRGVPVGRVDSLDITPDGVMIYLELDSGKPKVPASAKAVIANRSAIGEQYLDLVPETSKGPYLRDGSVIDGAETPIPVEDLLASVNHFSSTTDLTALSTTVTELGKAFDGQGDNLRILVDSLNKFSQTGVEALPQTVQLIRDAQTVLGTQADQSPAIRTFSDGLDRLAVQLRANDPDIRRLIGTGADAGEQIGKLLDQSAQPLTTDLSNLRLLLQAVSPQTYTLKPLLQMLPLLSVGGSATAPGDGTTHFGLVLETNNPPACTVGYEGTQRILDQMKAQNPNFDDTRDDFPFNTDAKCDVPFGSPTDVRGGARAQYADPNVPQPWDSKPKTDPDKLNLSPVAIQLATLIGVTPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H510</accession>
    <name>A0A231H510_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="2">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ahpD_3</name>
        <name evidence="2" type="ORF">B7C42_04137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43898">
        <property type="protein sequence ID" value="OXR43898"/>
        <property type="gene ID" value="B7C42_04137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="17423" checksum="45518ED38E93183B" modified="2017-10-25" version="1">MQTPAADARIWIDKQSPEPFHALSNVALAVRTAAAAAGLDRSLVELVNVRVSQINGCAYCLDLHSQAALKAGVTRQQLDVLPAWRRTELFTPSECAALALAETTTTLPDEDTLQRVYAHARKQLSDEQFSVIVWVATTIGAFNRVSIMSRHPVRERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5C5</accession>
    <name>A0A231H5C5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036500236.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44099">
        <property type="protein sequence ID" value="OXR44099"/>
        <property type="gene ID" value="B7C42_03655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="13926" checksum="B93DF6C86E062E75" modified="2017-10-25" version="1">MSSIQVADQTFVAASGAAVAEVLADRSRWHRWWPDLTLEVREDRGDKGIRWSVSGPLTGTMEVWLEPSLDGVILHYFMHAEPPGAAALSPRTLMAANRSRRVAGKKMSFEVKSRLEAGRPAGVAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H668</accession>
    <name>A0A231H668_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44503">
        <property type="protein sequence ID" value="OXR44503"/>
        <property type="gene ID" value="B7C42_03292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046252">
        <property type="entry name" value="DUF6285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19802">
        <property type="entry name" value="DUF6285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6285" evidence="2">
        <location>
            <begin position="378"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="461" mass="49473" checksum="D7D3005BA9061DEA" modified="2017-10-25" version="1">MAVSAESAAAEPVTLTEGVRAVLADTLGTSLTDVALRQFTGGASRQVYAVEARDGTGAAVRAVLRRDPPGHGDSARMHAEAVCLRAAGAAGVPVPAVLADGATAPGIDAPYLLMERVDGESIPRKLQRDPAFAAIRDRLAGDLGYVLGLIHRTPLDNLDVLDDHDPLAALEQIYRDLDDPRPAVEAGLRWLREHRPAERPKALVHGDFRLGNFLIEPDGVRAVLDWELAHLGNPIEDLGWLCVRAWRFGAEAPVGGLGSRQQLLDGYERSAGYRPTAAELHWWEAFGTLKWLVLSRFQAHRHLSGDERSLELAAIGRRVCESEYDLLTVLDLLDDTVSAPTPSDMPATVHDRPHPTEILELVADTLAAEIGPTLPPEQSRSRYLLRVCANLLGIAARELAAGPAATAEVHSRLAALGCESEAELAARLRSGAASYTDDAVRAAISAAVLARLRIANPRHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6C4</accession>
    <name>A0A231H6C4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782879.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44340">
        <property type="protein sequence ID" value="OXR44340"/>
        <property type="gene ID" value="B7C42_03901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="19203" checksum="A9FC8E7D2FC82128" modified="2017-10-25" version="1">MSIHGLYVAPGEGKRLVSAAHEVVFKVTGEHSTAASSFEVLVPPGFDVGAHLHHHSEELFYLVAGELEFLAFEPVSWEGHWSQWRSEEGRTVITAGPGSVVFVPPGCPHAFRNASDAPAKMFFQASPPPDHEHYFEGLIEIFRTGAAVDPAAVAALRRKYDIEQISELRYQPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6L0</accession>
    <name>A0A231H6L0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44663">
        <property type="protein sequence ID" value="OXR44663"/>
        <property type="gene ID" value="B7C42_03457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="944" mass="100446" checksum="3FB41E1149574CDE" modified="2017-10-25" version="1">MTADPFGTADLRAGVLTAWRNSPTRLREDAATEADLVRAGYRDRLLTELAQNAADAAVKAGVSGRVSVWLRGRALHIANTGAPLDLSGVHALTALRASGKTGTAVGRFGVGFTAVLSAGDEVEFRSTTGSLRFSRAQTLSELRDNGIDVPVGADGPAVPVLRLAWSVAVTPEPGFDSEIVVWLREDVDAADLLAAMRAEAVDLLLELPGLHTIRIGDDESWRAVEDLGNGLQQVRITAPSGEDFRWWQYTTERARWLLPMRDGRAVAASADVLRAPTRTDEELSLPALVIADIALQPDRRRLMPGARVAELAEGYADFARALPPGDRLVLVPAPGFARSEADGLLREALVKQLRENPWLPVLAPAAGASEDPADAGFALPDFGAGASGDDVAAPVRTDAAPARASVFPGVTTELADLLATLLGPLVVPELSGRATAELLGVLDVHRIGLARVAELTGSVQRPPQWWYSLYDALEPFVTDPLAAEELGALAVPLSDGRLVTGPRTVVLDDQLEDAVAVPWARLVHPEAAHELLGRLGAQQAGVEDLLTDTALRAELDHRPDDEDLREAVLGLAAHLPAGITLPTWLGGLELPDSTGESRPADELLLPDAPLAEVLVGDSPFGTLDPEFAQHHPASALRAIGVGWGFTVVTETDPTGPDHDLDDEDRWWRGLPEDPPEFAAVRDLDLVADDAWPQALGLLLSEPATRGLLADRDGYTAWWLRRYARVDGRPLGVHRAGSDPVFADLLPDLPGFSAADLAALDAVLADPANITVDLAVALLEALADPAKRPTPEAVSQTHRRLAAAVPQLDLDEIGVPERVRALSGAVIDPDRALVLDRPWLGLALPPDRLVAGDIEHAGELATLLDVAAASEAVHAEVLGAGKRTTWADEPLGVLLRLQFGLPPLAGELVLHDRLEVRLTGAYEATVAVPWWRSGETTHVQRQPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Z5</accession>
    <name>A0A231H6Z5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44517">
        <property type="protein sequence ID" value="OXR44517"/>
        <property type="gene ID" value="B7C42_03306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="30524" checksum="3535221CC7E55F60" modified="2017-10-25" version="1">MSQPAAGAGVVAQQGPSGSAGPTPSDDGQYDGDLTIPGRSATSSTTAPSQVSAAPPPVTPTPVAGEGFAGLASILGTGSAAVGSAAAGSAASGSALTGSALGGTGSAATGSVAGATGSALAGTGSAAAGTGSAAAATGSAATGSALATTGSAAAGVGSLLAGILGTGSAATGSALAGLAGTGSVATGSALATLLGTGSAVTGSAAVGSAAAMSPLLLLLLLQPVPPPAAPAAPPLAIPPVPPVPAVPGAPVVAAAPAAVPPAAPPAPAPAPAAPAAPAPALAQPNPAVRPTAATSGLPEVKTLAVLGGVIAMALAAAGSGAVSFQSASAAQARIDAARAEFFGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H752</accession>
    <name>A0A231H752_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-methionine sulfoximine/L-methionine sulfone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pitA_1</name>
        <name evidence="2" type="ORF">B7C42_02708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44754">
        <property type="protein sequence ID" value="OXR44754"/>
        <property type="gene ID" value="B7C42_02708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="183" mass="20324" checksum="0F6462F40250A668" modified="2017-10-25" version="1">MTDIQSGGPRIRDAEERDIPTILAIHNDAVAETTAIWDTQPVDLDDRLHWWRDRVAAGYPVLVAIIDGQVAGYASYAQWRPKSGYRYCVENSVYVSERFQRRGAATALLTALLGRAEESGRVHTVIAAIETSNKTSILLHEKFGFRIVGQLPEVGHKFGGWMDLTLMQRTLPGPISAGVESFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7L3</accession>
    <name>A0A231H7L3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44716">
        <property type="protein sequence ID" value="OXR44716"/>
        <property type="gene ID" value="B7C42_03510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012195443" evidence="2">
        <location>
            <begin position="29"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="26083" checksum="1D3AAE2FFBB6458C" modified="2017-10-25" version="1">MKSSVLIAVVVGAVALSGCGAGDDGASAPTSSDPVARQMTAAPDQDAGCPLPAAPSAGPYSAITVPVREQTPSLTTDVVLPQLEAGDQAVRDRFNSAMRASLADLSGGAANGALHAARLRCGETSRVTRIGAHVVAGVLITDHTWEGGPHPVNQIGTVVIDTGTAQPVMLPTALRDPGQAWGALATAAQSLVPADGPTLFTHTPGADDFAAWVPAPAGLTVYFPVAHARGDYYPVQLPWNRIRDLFDPAALATLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H815</accession>
    <name>A0A231H815_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfofructose kinase</fullName>
            <ecNumber evidence="2">2.7.1.184</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yihV</name>
        <name evidence="2" type="ORF">B7C42_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.184" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44988">
        <property type="protein sequence ID" value="OXR44988"/>
        <property type="gene ID" value="B7C42_02945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061594">
        <property type="term" value="F:6-deoxy-6-sulfofructose kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="288" mass="29743" checksum="98B64CFF6F3AE653" modified="2017-10-25" version="1">MSVPLFVGLTTVDLSYAVDAYPGEDTKTRAREQFLGAGGPAANAAVACAILTGGARLLTAVGQHPLTALIRDDLRSHGVELVDTTPGRTDPPPISSIVVAAAAGTRTVVSLDGSGIAASFDDECAALVQDASVVLVDGHHLELALGIARVARDAGIPVVLDGGRWKPEHAELLPLVDIAICSASFAPPGAQDVFDHLHRIGVRAVAVTRGQQPIVYSANGFRGEIAVGDVDGADTLGAGDILHGAFCAYHSRGHDFVDALTRAAAVATLSCRFFGTRAWGDRLDELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H817</accession>
    <name>A0A231H817_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peroxiredoxin</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_02853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_062999484.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44897">
        <property type="protein sequence ID" value="OXR44897"/>
        <property type="gene ID" value="B7C42_02853"/>
    </dbReference>
    <dbReference type="GeneID" id="66721990"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="16984" checksum="AD1850C7CB1D0086" modified="2017-10-25" version="1">MPLEVGTAAPDFTLKDQNNQDVSLADYRGHKNVLIVFYPLAFTGICQGELCKVRDELPKFQNDNAEILAISVGPPPTHKIWAAEQGYTFPLLSDFWPHGAVTQAYGVFNDKTGFPNRGTFVVDKDGIIRFAEMNGPGEPRDQAAWEKALTALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8P8</accession>
    <name>A0A231H8P8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45172">
        <property type="protein sequence ID" value="OXR45172"/>
        <property type="gene ID" value="B7C42_03130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024414">
        <property type="entry name" value="Uncharacterised_PrgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12666">
        <property type="entry name" value="PrgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="2">
        <location>
            <begin position="591"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="2">
        <location>
            <begin position="748"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="998" mass="105618" checksum="8E37697D9FC148BC" modified="2017-10-25" version="1">MTTPVRIPADVERRDRLIGPFTARQLAILAATALLLYLAWMATRAVLAPLAFLAVATPIATVVTVAISTTRDGLPGDQLLVAAIGHKLRARHLVRDAGRTEPVPRWVADQAMRGPRPPLPATLSTDAVRLPRAVTGSVSGVGVVDLGADGLAVVAAAGTLNLALRTPAEQDSLLAQFSGWLHTLRQPVQILIRSARLDITAHLSALDAATADMSPQLAAVARDHADHLADLAATENLIQHQVLLIWREPIRTPDAPALSPLIPRQRRSLGRASAAARRAAESRLVRRLSEATDLLAPLGVSVTALDEFQATAVLDSCCNPGSLVASSADIAGPDEIITAAGVQPTRVGGIGLVAEEDDESGAEALSFGPESLSIRARHLEVGSDWVATVAVTGFPREVTSGWLTPLLSHPGRLDIAVHVDPIDPVTAAGRLRRQLARLESSRLHDTSRGRPPDPQVDVAVEDAAELSARVARAEARLFRVGVYVSVHADSETELADEVAAVRALAASLLVDTCPLGFRAAQGWVTSLPVGLDLIRIQRTFDTAALAAAFPFDSPQLPVTDPIAATQPRGVLYGRDAAAGLVFVDRFAPEAHNHNMVVLGRSGAGKSYLAKTEILRSLYRGIEQVIIDPEDEYRRLADAVGGTHIRLGAPGVRLNPFDLDIRTGSDGRRTAPSDALTRRKLFLHTLIQILLGDQTATQRAVVDTALTATYAAAGITDDPATWTRPAPTMSMLRDQLAGFDTPTAHELAAGLHPFVDAGAYAGLLDGPTTTDPDGGLVVFSLRDLPDELKTIGTLLALDATWRRVSDPATRRPRMVTVDEAWLIMRQPAGAQFLYRAAKSFRKHWAGLTVATQDSADVLSTELGRAILSNAATQILLRQAPQAIDEVAAAFKLSDGEQQFLLTAARGSGLLALGGGDRAVFASLASPTENALITTDPSELAFLADGSDDVDIEVSALPSSRPHASHGKQGYREDDTETAGAAGIDIDVAHEVVVEAEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9K6</accession>
    <name>A0A231H9K6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xylulose kinase</fullName>
            <ecNumber evidence="4">2.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xylB_1</name>
        <name evidence="4" type="ORF">B7C42_01926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45634">
        <property type="protein sequence ID" value="OXR45634"/>
        <property type="gene ID" value="B7C42_01926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="492" mass="52532" checksum="DAC7505CE6549031" modified="2017-10-25" version="1">MFIGIDIGTSGSKGVLTDADGTVLARSERPHEVSMPRPGWVEHDAESVWWADFVAIARELVDAAAGARLEGLGISGIGPCLLPADAQGNPLRAAILYGVDTRATVEIAELADELGEAAVLERAGSPLTSQAVGPKLRWLARHEPDVYARTRMLLMASSFLVHRLTGRYVLDHQSASQCVPMYDLRKREWSEWTEQCAPGLLLPELAWPTELVGRVTAEGAAATGLPEGLPVTTGTVDAWAEAASVGVRGPGDAMVMYGTTMFLVQILTQPRPHPGLWSTCGAWPETYSLAAGMATSGAVTDWLRRLVGGEFGDLIEEAGKVPAGSRGLLMLPYFAGERTPLFDPDARGIVAGLTTSHGRADLYRAALEATGYGVRHNLEAMSDAGGRARRLVAVGGGTRGGLWIQIVSDVTGLPQELPAETVGACLGDALLAAEAAGVDTSRWNPVTSVIEPDSERQAIYDQYYRRYRELYVSTADIAHFLAAEQHRTADHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9L4</accession>
    <name>A0A231H9L4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776481.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45521">
        <property type="protein sequence ID" value="OXR45521"/>
        <property type="gene ID" value="B7C42_02646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="405" mass="43722" checksum="AD404E3E52151B2B" modified="2017-10-25" version="1">MGKVGEQHAGVAVRVAQARKLAGLTQSQLADRANISVGLVRSVEQRRVPATAAFVGAVSKALRVSVTDLTGQPYPPAPGADTAMHSVVAVLRTELAAFDIDNANISWVRPMTNIATDVERISRYRRNASFHKLAEELPALLGEVRATVHRTSGQIRDQALMMMCELYYSSHSLAHKLGYTDLATVAVDRIAWAAGESTSQLWKATSQFQRAALLSSGGDWAAALTFLEQCRVEIEPRLGAGRRSDLIAWGGLHLQSGLAAARSGKRGLADAHLSEARETASRLGDDRDTILSFGPTNVGIWSVALAVEAMDGTEALNRAKALVIPSDAPKERAGHHYIDLSRAFLLHGNRRHAFTALQTAKSIAPAQTRYNPMVHETVRALARAEARSVETVRGFAVWCGIADRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA29</accession>
    <name>A0A231HA29_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkaline phosphatase synthesis transcriptional regulatory protein PhoP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoP</name>
        <name evidence="6" type="ORF">B7C42_02002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782724.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45710">
        <property type="protein sequence ID" value="OXR45710"/>
        <property type="gene ID" value="B7C42_02002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="233" mass="25615" checksum="F21D94D692E76C39" modified="2017-10-25" version="1">MEQNPLVEGTPARRILVVDDESTIAESVAARLRAEGFTVATAPDGPAAVAAARTFEPDLVVLDVMLPGFDGLEVCRRIQAERSIPVLMLTARTDETDQLIGLGVGADDYLTKPFSLRVLTARVHVLLRRVERAGDQRGAVTVVGDLRIDSDQRRVWRGGVEAQLTPLEFDLLARLARRPRAVLARERLLEEVWDWADAAGSRAVDSHIKALRRKLGADLIRTVHGVGYALETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAB7</accession>
    <name>A0A231HAB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45903">
        <property type="protein sequence ID" value="OXR45903"/>
        <property type="gene ID" value="B7C42_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="66" mass="7469" checksum="4E4F649FFBF31B99" modified="2017-10-25" version="1">MWQWLCRFVAGRRRLTDMTTLLIIAVVAAVAAALFDTVAPRGDRAEFRCALRHARHSLTDWGAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAM5</accession>
    <name>A0A231HAM5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B7C42_02297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR46004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46004">
        <property type="protein sequence ID" value="OXR46004"/>
        <property type="gene ID" value="B7C42_02297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="88"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR46004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="676" mass="71174" checksum="38345CD38041B881" modified="2017-10-25" version="1">MTVTTADTAVPVSPESARPPDPDLPPPRRRDRIALALLLAATAAAYLWHITVNGMGNGFYAAAAWSGSRDWKALLFGSLDPANFITVDKPPVSQWVMGLSGQLFGFSSASMLVPQALMAVAAVALMYGAIVRATGSRGAGLLAGLLLALTPVVALMFRFNNPDAVMVVLMTAAAYCTVRALRHASPRWLVLAGVALGFAFLAKMLEGLMVLPALGAAYLVAAPAGLGKRIAHLLAAAVALVVSSGWYVLLTILWPADSRPYLAGSKDNTFMDLVLGYNGFARYLGHNHAGRKPFELPPGYELPHMGGGSGGFGSGPDRLFTGEIGFEISWLLPAAVLGFVVVLGTRWKSPRTDIVRGAALVFGLWLLIDGVAFSAMKGGMHAYYTLAIAPAVVGSFVLGLAEVWRCRDRAWGRAGAAGLVAAGGVWGFVLLDRNPDWQPWLRWSILAVTVVAAAALLATVLPAMSRRTPARAVAVAVGAGVLAAAAGSSAYAVATLPQSHTGGSPVVGPARPELPQALNPFRRQIGMLMGGTDTDPRLVEMLRATHTTWSAAIDRSGPAAGLELASRTPVIAIGGFTSEDPVPTVAGFQDLVRDHRITYYLAPEMKLPESWRTRDQHRSPGATPTPATAPDPSAAGTEPELWHPVGNTDIYAWVAAHYTPQHLGGLEVFDLTAPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB04</accession>
    <name>A0A231HB04_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen regulation protein NR(II)</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glnL</name>
        <name evidence="4" type="ORF">B7C42_00988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46025">
        <property type="protein sequence ID" value="OXR46025"/>
        <property type="gene ID" value="B7C42_00988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="324"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="509" mass="55981" checksum="E6D0F8BD074D4E63" modified="2017-10-25" version="1">MSDSDQNGAVSDSDQNGENRTVTGPRTLCDPAELRTLFLFEKLDEEQLAWLCREGRVEYFEPGPVYREGEPATCFYVLMDGEVVLSKLSAGEDLELVRTDHRGSYAGAWTAYMGERADQNYTGSLTVTKPSKFFVLDAETFARMMREWFPMALHLLEGVFFGNRNTNEIIGRRERLLALGSLSAGLTHELNNPAAAAVRATSSLRDRVAGMRHKLKMMAHGKFDSAALEALVQLQEEAATQVAKAPTLTAMEAADREDELGDWLADHNIANGWDLAPNFVQAGFDIDWLEKVAGTLEHCDDGVFEGAIRWLNYTVETELLMNEITDSTGRISSLVHAAKQYSQMDRAPFQVVDIHELLDSTLVMLARKIGDDVAVVKDYDRLLPEVPCYAAELNQVWTNLIDNAVAAMNGSGTLTVRTYRESDCAAVEIGDTGPGVPEELRDRIFEPFFTTKPVGEGTGLGLDISFRIVVNKHGGDIRVESTPGDTRFIVRLPLEAASGRGSATAAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB35</accession>
    <name>A0A231HB35_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaK_2</name>
        <name evidence="6" type="synonym">dnaK</name>
        <name evidence="10" type="ORF">B7C42_01109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030516678.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46144">
        <property type="protein sequence ID" value="OXR46144"/>
        <property type="gene ID" value="B7C42_01109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="583"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR46144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="613" mass="65397" checksum="75480E9D541F0E81" modified="2017-10-25" version="1">MARAVGIDLGTTNSVIAVLEGGEPVVVANSEGSRTTPSVVAFAKNGEVLVGQPAKNQAVTNVDRTIKSVKRHMGEDWTVEIDDKKYTAQEISARTLMKLKRDAEAYLGEEITDAVITVPAYFEDAQRQATKEAGQIAGLNVLRIVNEPTAAALAYGLDKGDKEQTILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDNRIVTWLVDKFKASSGIDLTKDKMALQRLREAAEKAKIELSSSQSTSINLPYITVDAEKNPLFLDEQLTRAEFQKITSDLLDRTRAPFQSVIKDAGISVKDIDHVVLVGGSTRMPAVSELVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTKLIERNTTIPTKRSETFTTADDNQPSVQIQVFQGEREIASHNKLLGSFELTGIPPAPRGVPQIEVTFDIDANGIVHVTAKDKGTGKENTIKIQDGSGLSKEEIDRMIKDAEAHAAEDKSRREEAETRNQAESLVHQTEKFIADNSDKVPAETKEKVEAAIAEAKQALQGSDIAAVKSAVEKLATESQALGQAIYEASAAEGGAAADGAGNASAGDDTVVDAEVVEEPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB74</accession>
    <name>A0A231HB74_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fadB_1</name>
        <name evidence="2" type="ORF">B7C42_01036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043343.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46072">
        <property type="protein sequence ID" value="OXR46072"/>
        <property type="gene ID" value="B7C42_01036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="270" mass="28741" checksum="EFEB383AB13A9B4A" modified="2017-10-25" version="1">MSETTETTGTETTGAETPFVRYDLRDGFAVLTLDSPHNRNALSSKLVRELLDGLRKAGADEQARGVILTHTGNTFCAGADLKEALDADPAAAADIRTRWMIDVLRGIVELHKPVLAQIDGNVRAGGMGIVGACDIAVAGPSSSFALTEARLGLAPFMISLTLLPRLTSRAAARYYQTGETFDAAEAERIGLITVAADDAAAEVARLCGELRKGSPQGLAESKRLVNASLVAEFDRTADELAKRSGSFFGTPEVIEGMTAFFQRRPPSWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBB8</accession>
    <name>A0A231HBB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46170">
        <property type="protein sequence ID" value="OXR46170"/>
        <property type="gene ID" value="B7C42_01135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="279" mass="28988" checksum="260AF0BC8B985623" modified="2017-10-25" version="1">MATDKVWLITGASSGFGFALTRAVASAGGRVAATARDPERARALRALAAEHPEQILVAPLDVTDAEQSRHAIEQAKQTFGRIDVVVNNAGYGVFGALEEIPDSDVRAVFETNVFGSLNVVRAALPVLREQRSGHLVQISSVAGVAAPSPGLGLYAATKFAVEGMNEGLLREVAHLGIDVTIVEPGMFGTGFVASLGITPAAHPDYGDSVRAAYDRLSTLDPSVYGDPDDAARRIIAAVESPTPPLRLPIGRDAITAIRAKLTGELAALEALDSATASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBI7</accession>
    <name>A0A231HBI7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46077">
        <property type="protein sequence ID" value="OXR46077"/>
        <property type="gene ID" value="B7C42_01041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="571" mass="61039" checksum="B58AA038FD8CB9A4" modified="2017-10-25" version="1">MTSLGADPEVLRIGNCSGFYGDRLSAMREMLEGGQLDVLTGDYLAELTMLILGRDRMKDPSLGYAKTFVRQLEDCLGLALERGVRIVANAGGLNPAGLAQRVTEVADKLGLTPKIAYIDGDDLLPRAQELGLGAPLTANAYLGAWGIAEALNAGADIVVSGRVTDASVVVGPAAAHFGWAREDFDALAGAVVAGHVIECGTQATGGNFAFFTEIENLDRPGFPIAEIRRDGSSVITKHANTGGAVTVDTVEAQLMYEIQSARYAGPDVTARLDSIRLAADGDDRVLISGVTGEAPPPRWKVSLNTLGGFRNEMTFVLTGLDIEAKAALAQRQLESWLPVRPAELDWSLSRLDRPDAETEEQASALLRCVVRDPEPDKVGRAFSSVAVELALASYPGFTMTTPPGNGAPYGVYTAGYVDAAEVAHTAVLPDGTRVPIAPPTQTRELDEVPEPELPQPLPAGETRRLPLGSIALARSGDKGGNANIGVWVRTDDQWRWLVHTLTVDTLRALLPETAKLTVTRHVLPNLRAVNFIVEDLLGLGVAYQARFDPQAKGLGEWLRSRHLDIPVELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC12</accession>
    <name>A0A231HC12_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781724.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46375">
        <property type="protein sequence ID" value="OXR46375"/>
        <property type="gene ID" value="B7C42_01341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="65" mass="6940" checksum="523FA8B925A1C4CE" modified="2017-10-25" version="1">MDRGLRNTSPRYRKLLPGDWVEHLIVGMLFVVSAVGVYVLTGAMLSSLLIGALVAVVAIGVVTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC15</accession>
    <name>A0A231HC15_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46237">
        <property type="protein sequence ID" value="OXR46237"/>
        <property type="gene ID" value="B7C42_01203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="11897" checksum="53EEA5EC82EFF24D" modified="2017-10-25" version="1">MHTAYVTVTIVAAVVIFGATVVDIVNPEWVRGNMRSYGVPDWALMPLAAIKAAGALGLLAGLVFSAIGLAAAVGLVLYFVGAVITIVRARWYAHLPYPMPCLVLASAAACLSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCD2</accession>
    <name>A0A231HCD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036496952.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46505">
        <property type="protein sequence ID" value="OXR46505"/>
        <property type="gene ID" value="B7C42_01475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="152" mass="16763" checksum="C481644334D224F6" modified="2017-10-25" version="1">MTAVKIVADCAAPAETAFDYVNDYRHLPEFVTEVHSFRPITDQVAGLGATFDTEIKLGPASLTSRLQIVRWEKNVAIAVKAVTGFEIESTFLFHPRGDRDCTVDAIVEYRVPGGLAGKVLGKTIEPFVKLSVKHTTHNLTTKIAEYQRTLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCG9</accession>
    <name>A0A231HCG9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_01489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775118.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46519">
        <property type="protein sequence ID" value="OXR46519"/>
        <property type="gene ID" value="B7C42_01489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="238" mass="24664" checksum="D946582654C9DE6D" modified="2017-10-25" version="1">MIAAILLSFGVLFVAELGDKSQLMALTFALRYRWWIVLGGITVASVLVNVIAVGVGHFLGAALPTDFIALCTGLILLAVGVWTLWAARHEEPDPDEPETTGPASPGRAFLIVISSFLLAELGDRTMFATIALASNHSWVAVWVGSVAGMVAAGGLAIAIGITVGKHIPERAVAVASGLLFLYIGAATLLGAIAPDLGKLGEYSIAAVVPLVGGALWGVLGRANRTDEEPAEPHSLHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCX0</accession>
    <name>A0A231HCX0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46764">
        <property type="protein sequence ID" value="OXR46764"/>
        <property type="gene ID" value="B7C42_01742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012872849" evidence="1">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="18405" checksum="3A5C794B63DFEB5B" modified="2017-10-25" version="1">MAACRLAIVLLAAVVPVLAACNGADDGGSGSTTSAAAVKLWDPCTQIPDDVLRKTGVDPATKESGIAGVHQSGWEICNWKGKQYTVNVLSGKRSVQEIENKDGNVDFRDVAFAGRQGRQFRVEGASKNDTCDVVFPAAQGVFQVMISNSAIVDNPGDPCVTLGKVSEQLVPLFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD03</accession>
    <name>A0A231HD03_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46676">
        <property type="protein sequence ID" value="OXR46676"/>
        <property type="gene ID" value="B7C42_01651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10145">
        <property type="entry name" value="PhageMin_Tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMin_Tail" evidence="3">
        <location>
            <begin position="212"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1501"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1510"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1828" mass="189411" checksum="6A16B4A0B194A107" modified="2017-10-25" version="1">MAAVYFDIVSRIVGMEAAAAEVVGKSVKAGEQAGTGFADAFKQKVLGESAGMSAQMTAQVNSATAALESASARTVKARQAEADAAGRVRIAESAMNDARQKYAADSTKYIKAEENLETAKRKQIAASGDVVAALAAEGKAQESLTAKHDAAAASAGTMGMAMKGAAVTGVAAVGVAMAESVKAAADFQETQTRLVTTAGESKDALAGVSQGLLQMAGETGYSAQELSKAMYTVESATFHGADALTVMKAAAQGAAQEGAPLHDVVDALTTSLKDFQLPASEASNQVSQMVAAVSHGKTTFGEFSASIGSVEEAAHQSHIPMSDLYADLATMTLHGITADRATQNLNRAITTLQKPSSDMTTGLANIGINAADLADKLSNKGLSGTFEDISVAIMQHMGPAGRVMIDTFNQSKTAAEDVAKAYAGLPDKLKTIADAVKRGDIKPTVGALEGQGLNLDEAHIVAQYAQMEAKATGLNSTLTSLKNSDKTYQQMLIQATGNQETARVAANLVGGDEGDTGGSAGGNFADVQAARADIEAAHSEGPAGDVKGWAEVQSNFNQKLKETKAQVGAWAIEMGDHLLPAATKVLEGVQHLVQWTEQHRAGIANLAREIGSDAMPVLNGLGHALGDVTHWLMDGAHWLQEHKTLTSDLVHAIVWAGEAWLGWKAATATFSLVKGGVEGITGAIGGVKSAASTVGSAWTSLSSGASTAASAAQDWWNWTGKFKAQAIGDFVATKVSAASEAAQAAGAWVMQGLRAGGAWVAMKAQAAAQFAATTASATAEAATTAGSWVAAQVTTGAGWVGMQTKAIAAFVATKVSAGVNALETAGLWVAQNARVIASFVAVEGAAIATGVAQKGMAAATWLVNAAMDANPIGLVIAGLTALVAGVVYAYNHFEWFRDGVNAVWHFIWDDVIHPIVDFIVDYYKAWFDIGVWLYDHGVKPMMDNIGAAWHWIHEKVIQPIVDLIKAEIRGWGEIYQWLHDSVIKPVGDKIGDALGLVRTGFSNTVQWIGDQWGKVEKIVGTPAVAIIDLVYNNGIVSLWNGIADVFHLGKLDKVDTSKIPHYATGGVHGVMSGWSPGRDDRMIAVGGGEAIMRPEWTAAVGSGYVHAANAAAMHGGIRGVQNFIAAGGAHFDTGGIFGDIVDAGKSLVSDVVDVAKFSAKLATDPAGAVRDLFKPVLDQAAQTPDGGSDQGMSQWRDMLIGLPGHFVDAVIDKAVSLGKSLIGMSGGNEPWVSGAGAEQWAPVIIQALQLEGFPTTPEYVNATEAQIMTESGGNPNIRQQVIDVNSGGNEAEGLVQVTPRTAAWLGLAELGGNIHDPLTNLRLGMRELKAQHGGDLLGTWGHGHGYAEGGIVPGAAGVTTTQKPASGPEQALAQIREHQSTMYAWGGADLATGVDCTGLIGDAIQIAQGVANPTGRLGDTTSLLAGQWPHVLSGASSSDIFTIGANATHAAANILGTNIEARQTGERIRIGTDAVSPFDSQFTAQFHVDPSVFNPPYIAAATGTGSKSKKTPAEKAKALRDSEQKQLDAAKKSDESAAKHDQAVNDYHAKAAHAQELADKSQGKARDRHLAAVKDYNDKADAAKAAADKARQQAEEHRKKAADYEQKAKTAESQPDTSTSTGTSSSGSGTGTTGTGTESGGLLTFEQLGERAGGIAANAFIETFGLGDTLLADPNKSPLLKAAGQLGNLKIQGQPVFINPLQHLNSGPAKALPLVQAAPQAQAIPEQLKIVDPDDMSDDLDPTHDLGGLLPPGLSIVNNKLGHGEVTVLPHEKLGPAEQPVGAGVGSSPSRSGPLLHIENWHAGGNGGTSDARAIAREFAVYEGALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD99</accession>
    <name>A0A231HD99_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46697">
        <property type="protein sequence ID" value="OXR46697"/>
        <property type="gene ID" value="B7C42_01672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="24197" checksum="D3DF9A3AA5AEAD00" modified="2017-10-25" version="1">MREVGEVIEARRVDLGLTAKQLAARMGTTEVQISRWVNGKQQPGPPYLRLLAQVLNLTADELLGFVEYETDLSKKWIAFWDTTRGGEPVIDQHTIQATHRGAYFTFSADGDYLWTGNLKLGNGSLTGTYLSAEADRLFEGALYFTLSPDAKAAVGKWSGRWADGLVGGGWGVLARDERRGDWLIRKVIADGPLSEWPADDPWLQERADAAHTEMMEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDB7</accession>
    <name>A0A231HDB7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative succinyl-CoA:3-ketoacid coenzyme A transferase subunit A</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">scoA_1</name>
        <name evidence="3" type="ORF">B7C42_00036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46921">
        <property type="protein sequence ID" value="OXR46921"/>
        <property type="gene ID" value="B7C42_00036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:3-oxoacid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="247" mass="26084" checksum="F50822F7B0BD0007" modified="2017-10-25" version="1">MKRYESAASAVADIPDGASIAVGGFGLCGIPSQLIDALAAIEVNGLEVFSNNCGVDDWGLGILLSAGRIRRVTASYVGENKEFARQYLSGELEVELTPQGTLAERMRAGGAGIPAFYTPAGVGTSISDGGLPWRYHPDGSVAVASPARETREFGGKTYVLEEAIVADFALVHAEIGDTEGNLVFNKTAMNFNPLAAMAGRVTIAQVEKLVQPGELDPSQVHLPGVFVQRVVHTGLQDKRIEKRTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDJ2</accession>
    <name>A0A231HDJ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46949">
        <property type="protein sequence ID" value="OXR46949"/>
        <property type="gene ID" value="B7C42_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="73" mass="8762" checksum="AF11A315F7F89F71" modified="2017-10-25" version="1">MTSETWFPPADDVHLRIWLGDMVFDYAVSAVVVHNLIEDWSRRRWCTIEFMRDTAEKRLLPRRLPCERLFLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDM1</accession>
    <name>A0A231HDM1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">menG_2</name>
        <name evidence="2" type="ORF">B7C42_01826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46848">
        <property type="protein sequence ID" value="OXR46848"/>
        <property type="gene ID" value="B7C42_01826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="243" mass="26980" checksum="5E8A8B363982D1A1" modified="2017-10-25" version="1">MLTVDFDRLGIGPGVRVIDVGCGQGRHSFEAYRRGADIVAFDQNADDLADVKIMFGALAEADEAPDYAQAETVQGDALALPFEDGEFDVVIASEILEHIPADDGAIAELVRILKPGGALAITVPRWLPERICWLLSDEYHANEGGHVRIYRADELRGKVTARGMRFIHSEHAHALHAPYWWLKCLVGVDKPDARPVQLYHRMLVWDMMKRPWLTRVAESALDPVIGKSVALYFTKPAVSGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDY6</accession>
    <name>A0A231HDY6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47094">
        <property type="protein sequence ID" value="OXR47094"/>
        <property type="gene ID" value="B7C42_00216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="36988" checksum="C4E54C61AF373DEB" modified="2017-10-25" version="1">MTREHSRGRSGSDGGTTSVDGIRPAIRPDPTTNSPLTPPFPPLRKPNDGALSGTTPARKRPVRDLGKVAKQLSDRDWSILRSVAEHRYLTVSHIHAMHFGNMPPDSGLRTAQRVLARLRRDRVLGALKQRIGGHKAGSTGSVHYVDEVGDRLLRQASARQSRRPFREPTERFLDHQLGIASAHVALVEADREERIELVRCAIEPAAWRAYLGIGGVRLTLKPDLYAETASPPGSEYVDAAFIEIDMGTESIPTLLKKCHEYDAYRRQGIEQDRSDGAFPFVVWSMSADTEAKAERRRIALREAIDKDRKLPSSLFRVIAPDQLIAVMQKGADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HED0</accession>
    <name>A0A231HED0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper transport protein YcnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ycnJ_1</name>
        <name evidence="9" type="ORF">B7C42_00177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47057">
        <property type="protein sequence ID" value="OXR47057"/>
        <property type="gene ID" value="B7C42_00177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="8">
        <location>
            <begin position="246"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="678" mass="71949" checksum="F046E43EBF7BFDAF" modified="2017-10-25" version="1">MSSPQDPPADSDPQAVRPEATAFPVLAVVAVGLTALVAPIVVSLSAAQALTLLGIPDPGPLTTYGLPAVRALADFSGAVAVGSLLFAAFLCPPQRDGLLDVGGYRALRRAGIAALAWAVTSALLVPLTLSDTTGQPVRSVLRPDQIWHAIGKVDVAGSWRATAIMAILLAIGCRLALRWGWTPVLFAWSLLCLIPVALTGHSSSGGAHDVATNSLILHLVGMAVWVGGLFAVLAYAMRGGKYTGLAARRFSVVATCAFAVVAVSGVLNAWVRVPWDELFTTTYGRLVIAKTVALCLLGVAGFLQRRRALPALADNPRDRSALISYAGVEVLIFAATIGLAVGLGRTPPPDLKRVPSPAEVELGYNLAGPPTAARILFDWRFDIMFGTLAIVLAVLYLVGVRRLRARGDSWPVGRTVAWLCGCAVLLIATSSGVGRYAPAMFSVHMAQHMLLSMLAPVLFALGGPVLLALRALPAAGRDAPPGPREWVLAAVHNPVSRFLTQPAVAAALFILGFYALYLGGIFDAVVGEHGAHLAMNLHFLVSGYLFYWVVLGIDPKPRQVQPLTKVGMVFGSLPFHAFFGVALMSMTTVMGEWFYRGLGLSWNTDLLGDQRTGGGLAWASGEIPLVLVMLALLVQWSRSDNRTAKRFDRAADRDHDAALAAHNAMFAELAKRDREVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEH2</accession>
    <name>A0A231HEH2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase</fullName>
            <ecNumber evidence="2">1.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777820.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47294">
        <property type="protein sequence ID" value="OXR47294"/>
        <property type="gene ID" value="B7C42_00416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="31614" checksum="B972A85BCA772994" modified="2017-10-25" version="1">MELGFHIPIFDIDGGTPAIAGELARVGQAAEAAGATWLSFMDHYFQIEPTGLPAEANMLEGYTTLGYLAAHTTSIDLGLLVTGVTYRHPGLLAKIVTTLDVLSGGRATLGIGAAWFEREHRGLGVEFPPLAERFERLEETLRICAQMWDPQNNGPFEGKYYQLAETLCSPQPIHRPNVLIGGGGEKKTLRLVAQYGDACNLFGTSPEDVAHKLDVLRRHCDDVGRDFDTIRTTIMANNPRPNPDVRDEFVRSMADYAKLGIDAVLITPTTGSPAAWIEDMAPAVPQLADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEI6</accession>
    <name>A0A231HEI6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036499775.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47314">
        <property type="protein sequence ID" value="OXR47314"/>
        <property type="gene ID" value="B7C42_00436"/>
    </dbReference>
    <dbReference type="GeneID" id="66720840"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="81" mass="9056" checksum="F5D707FD198E7A39" modified="2017-10-25" version="1">MLRLIIGVAAGYVLGAKAGRARYEQISKTTRAVAASPVTRKLVQASRQKLSDRLNTQPRLEPMEPIDERTTVLVPQDQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEK0</accession>
    <name>A0A231HEK0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotine blue oxidoreductase</fullName>
            <ecNumber evidence="2">1.1.1.328</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nboR</name>
        <name evidence="2" type="ORF">B7C42_00473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.328" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782086.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47350">
        <property type="protein sequence ID" value="OXR47350"/>
        <property type="gene ID" value="B7C42_00473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="183" mass="18729" checksum="51D1A25264387F1A" modified="2017-10-25" version="1">MPDRVVGVVLAAGAGRRFGRPKATVGNWLTTAVDALRDGGCAEVVVVLGAARVPPIPATTTVTAPEWAQGMSASVRTGIGAAQRLDAAYVALHVVDTPDVGADVVARVIEAALAGPSGIARASFAGRPGHPVVIARRHWADLLPTLSGDRGAAAYLRSVRAPTVECGDLATGRDIDEPGDLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF86</accession>
    <name>A0A231HF86_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">frr</name>
        <name evidence="6" type="ORF">B7C42_00667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503637.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47542">
        <property type="protein sequence ID" value="OXR47542"/>
        <property type="gene ID" value="B7C42_00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR47542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="20824" checksum="701A4E7C0F955066" modified="2017-10-25" version="1">MIDEALFDAEEKMEKAVSVAKDDLGSIRTGRANPGMFNRVVVEYYGSPTPITQMASITVPEPRMVVIKPYEQGQLQTIETAIRNSDLGVNPTNDGTIIRVVIPQLTEERRRELVKQAKSKGEDAKIAIRNVRRKSMDELNRIQKDGEAGEDEVGRAEKELDKTTQKYVAQIDELVKHKESELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFG9</accession>
    <name>A0A231HFG9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47723">
        <property type="protein sequence ID" value="OXR47723"/>
        <property type="gene ID" value="B7C42_00848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15190" checksum="35A33A99367EF488" modified="2017-10-25" version="1">MMFADVRDPDGIRAVYAERGLPVMMIGPRPHLVTGGRFGLVAMPNRLGHRVIDALPVCGPVLGQPRSRRLAFVVASPAPDPPLALLHLLGLHAVVVVAPGRCVALPCHDGAGRSVLWVNEPRRDAAAPREAVIIDVALRLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFJ3</accession>
    <name>A0A231HFJ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042877.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47477">
        <property type="protein sequence ID" value="OXR47477"/>
        <property type="gene ID" value="B7C42_00602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="219" mass="23240" checksum="9E216E7BEC585AE3" modified="2017-10-25" version="1">MSAQSGSGSRRRQTDADFVLDTRSLGRAPGSIRQVHRVVTASGKIGLDLIAIPAGAEIDLDLTLQAVSEGVLVTGSVSAPIEGECSRCLESFTDDLELEITELFAYPDSATEQTTEEDEIYRLVDDMIDIEPVITDAVGLELPLQPLCEPDCAGLCPECGVRMAIAGPDHTHEILDPRWAGLAKFASETPGTGVSDAPSDVDRSLADRHGSASSTTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFX8</accession>
    <name>A0A231HFX8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobQ_1</name>
        <name evidence="4" type="synonym">cobQ</name>
        <name evidence="7" type="ORF">B7C42_00732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47607">
        <property type="protein sequence ID" value="OXR47607"/>
        <property type="gene ID" value="B7C42_00732"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="269"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="524" mass="55029" checksum="8CAEB65B422FDB36" modified="2017-10-25" version="1">MRFAAAAGAVNGALLVAGTTSDAGKSVVVAGICRMLARRGVRVAPFKAQNMSNNSVVTLDGGEIGRAQALQARACGLEPSVRFNPVLLKPGSDRRSQLVVRGVAVDTVGARDYFRHRRGLREVVAGELAALRAEFDVVICEGAGSPAEINLRATDLANMGLARAAKLPVLLVGDIDRGGVLAHLFGTVAILEPEDQRLISGYIVNKFRGDVELLRPGLDRLTALTGRPTLGVLPYSDELWIDAEDSLGTVADAPVGRPRPPVGTEWLSVAAIRLPRISNSTDIEALACEPGVAVRWVSDPSRLAGADVIVVPGSKSTVSDLNWLRRTGIADAIAAHAGAGKPVLGICGGYQMLGRRIHDDVESGAGEVDGLGLLDLEIEFADPKVLRRSAGHGAASGAAVAGISLSGYEIHHGRVRRSGDPAWVEISGVETDSREGSVRGAVRGTHLHGLLESDEFRRAWLREAARQAGRTGFAVASDTCVEAVRTAQLDLLADLIEKHLDIAALERLISDGAPAGLPTLTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFZ8</accession>
    <name>A0A231HFZ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779586.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47627">
        <property type="protein sequence ID" value="OXR47627"/>
        <property type="gene ID" value="B7C42_00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="13621" checksum="ACD5D29E83EA6D6A" modified="2017-10-25" version="1">MATDGVDPDLVELATKVFELARTGEAATLAAYIDAGVPVNLTNDNGDTLLMLAAYHGHQAAVTALLERGADPDRANDRGQTPAAGAVFKGEDDILKALLAAGADPDAGTPSARESATVFGRTELLELFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSN4</accession>
    <name>A0A231GSN4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cobS_2</name>
        <name evidence="19" type="synonym">cobS</name>
        <name evidence="20" type="ORF">B7C42_08296</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="NGAF01000115">
        <property type="protein sequence ID" value="OXR39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39636">
        <property type="protein sequence ID" value="OXR39636"/>
        <property type="gene ID" value="B7C42_08296"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXR39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="244" mass="23970" checksum="C6D47C9061F03C4A" modified="2017-10-25" version="1">MARLALSWLTVLPVRGPETVDRTAAAGAIAAAPVVGAVLGAGAAGVLWVSTWVGMGFALAGLVTVGALGLATRGMHLDGLADTADGLGSYGPPERAREIMKSGGAGPFGVAALIFAIGIQALSFAALAEHGRWFAVGLAVAVGRVAVVPACRGYAPAPGAGFGALVARTQSVVTLAVWTLVALVAGVVATPVRWLGPVAVAVALAGAAVLVWHCVRRFGGLNGDVLGAAVEVTVAVAAAVLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSR4</accession>
    <name>A0A231GSR4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000093">
        <property type="protein sequence ID" value="OXR39670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39670">
        <property type="protein sequence ID" value="OXR39670"/>
        <property type="gene ID" value="B7C42_08259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="49" mass="4768" checksum="61ECF3F0CD875661" modified="2017-10-25" version="1">MVVRISSTGLLGARYPPAVYSGAGSARVSSLPLTVSGSAATTITAAGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT45</accession>
    <name>A0A231GT45_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000065">
        <property type="protein sequence ID" value="OXR39790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39790">
        <property type="protein sequence ID" value="OXR39790"/>
        <property type="gene ID" value="B7C42_08142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="47" mass="4938" checksum="009175E22B070759" modified="2017-10-25" version="1">MDQYQVVDLAQRSVSSTGAVPEGHEPEPSYLGVVGLTPPSPVVADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT97</accession>
    <name>A0A231GT97_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000083">
        <property type="protein sequence ID" value="OXR39701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39701">
        <property type="protein sequence ID" value="OXR39701"/>
        <property type="gene ID" value="B7C42_08225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="48" mass="5351" checksum="473DA6E05634F9D7" modified="2017-10-25" version="1">MNAWALLGLAVCIGLPLSVLIATLVVPQLIPKDRKVDAIRRRIENEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTC2</accession>
    <name>A0A231GTC2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000059">
        <property type="protein sequence ID" value="OXR39832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39832">
        <property type="protein sequence ID" value="OXR39832"/>
        <property type="gene ID" value="B7C42_08094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="30" mass="3571" checksum="EEDF8FC131107446" modified="2017-10-25" version="1">MYRLSFYGDIKADSSNLVLTTVKEWFMQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTH2</accession>
    <name>A0A231GTH2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782398.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39924">
        <property type="protein sequence ID" value="OXR39924"/>
        <property type="gene ID" value="B7C42_07987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="106" mass="11362" checksum="0529B1F60447BDF4" modified="2017-10-25" version="1">MGADLFAAVANTYDTQVVELLENALSSGTEEMTLAVAAGLSEAPRTFIWDQPDFVCSALHAADRIGEEALQEMAGALWGATISGIRRSVPREPAPETIEQPIDHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTP6</accession>
    <name>A0A231GTP6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoglutarate oxidoreductase subunit KorA</fullName>
            <ecNumber evidence="6">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">korA_2</name>
        <name evidence="6" type="ORF">B7C42_07940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000047">
        <property type="protein sequence ID" value="OXR39989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39989">
        <property type="protein sequence ID" value="OXR39989"/>
        <property type="gene ID" value="B7C42_07940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="270"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="531"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR39989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="661" mass="70772" checksum="272FACE91B9E4D75" modified="2017-10-25" version="1">MQKANDVSQTKQVEQLDRVIIRFAGDSGDGMQMTGDRFTQESAVFGNDLVTLPNFPAEIRAPQGTIPGVSSFQIHFADHDILTAGDRPDVLVAMNPAALKANIGDLRKGATIIVDTADFTKRNLDKAGYDVNPLDLLGDSNDMLGDFDVQPVDLTGITVEAVKEFGLTRKDASRAKNMFALGLLSWMYGRPVEGTIAFLEKKFAKKPAIAGANVAAFKAGWNYGETTEAFVVRYEIKPAVLPPGTYRNITGNLALSFGLVAAGVRADLPVFLGSYPITPASDILHELSKHKSFGVTTLQAEDEIAGIGAAIGASFGGALAVTTTSGPGIALKSEAIGLAVTTELPLVVVNVQRGGPSTGLPTKTEQADLLQAMYGRNGEAPVPVVAPRSPGDCYAAAIEAARIAVTYRTPVFLLSDGYLANGSEPWRIPTLDELPEIHPDFATCPNHTAPDGTEVFWPYKRDEETLARPWAIPGTAGLEHRIGGLEKGDGHGDISYDPANHDFMVRTRQAKVDAIAKSLPPLEVDDPSGEAKVLVVGWGSTYGPIGAACRRVRRAGYNVAQVHLRHLNPFPSDLGDILESYDKVLVPEMNLGQLSKMLRAEYLVDAQGYNHVYGLPLKAAELAEAIGALVGRAEGREVDLREHGLDLPADHETDPSKEDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTZ6</accession>
    <name>A0A231GTZ6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40090">
        <property type="protein sequence ID" value="OXR40090"/>
        <property type="gene ID" value="B7C42_07845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="305"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="43146" checksum="350A13BF4EC0D8FF" modified="2017-10-25" version="1">MDEPGAEAPRLRELGADPAAVLRLIRYFDGFDESDSNADTVVRAAALLAECPAAASWPSGTVIRYDAAGRPLPAVMPPPEATGEPAVWLERTGAAHALDAVLVDRLRHCLRVVAVRGSATAPTGLDDPALLEVVLSEKQRREDRVRAMRLLGIDPAQPTRVLAVSGPGAAEAVRIIGARGRVVRSAVIGATTAVLIQDRETCRELSDVLNSAVVQEFPASRRGAGGPWVGMGERLPAYAAATSWEQARRALRFASSTWHGRRVVAYERLGSLALLGELPVQRLLGTSDVLRVNAFAATEAGALAVDTLEAFCVFGSLRRTAAELHLHHSTVAARIAQVEAVMGWDVDEALDRFMATLALMVRRIALSSAELAADPGAAGRADPTDVGGIRPFRRHAAGDPDHSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU21</accession>
    <name>A0A231GU21_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor ComR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">comR_7</name>
        <name evidence="5" type="ORF">B7C42_07787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000040">
        <property type="protein sequence ID" value="OXR40123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042678.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40123">
        <property type="protein sequence ID" value="OXR40123"/>
        <property type="gene ID" value="B7C42_07787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="213" mass="22829" checksum="40FAA1AECA92780E" modified="2017-10-25" version="1">MPPNTAARRGRGRPSVLDTRAVAESALRLWSERGYSTTSWSDLADATGISARTLLRHFSSRSDIAYLGVEPATSRLRDALGKATDADDPSAVIRAAVVESVSHDPRISRIAPHWLRLISAEPELAAIAPLAYRPWIDTLATYISGVLPDAPLAICRALATAYQAASFAALVEWADGGAEGDCADVVDEMLRWMDIHAPVGVRGDRSTPATNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU43</accession>
    <name>A0A231GU43_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000039">
        <property type="protein sequence ID" value="OXR40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40147">
        <property type="protein sequence ID" value="OXR40147"/>
        <property type="gene ID" value="B7C42_07771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="372" mass="41236" checksum="21367785744A5F74" modified="2017-10-25" version="1">MTIALKVLLQNQRLHEHSAFSAEYKRHAAALGMDRNAAVPPTKGQYYKWLAGTLTSVPRGHHCRVLESMFPGWTAEDLFSTTDMVGDRLKRLSRNSFGRGQLADAVAAALQARDISVTGWGSARLPVTVGTGAPQLPDAVGDFDEADLPPDARRIGKKLAALAQVLRLSPTETVQLAGLVGNVVELELRIEVHIDGDGNSRLVYTHDVFNMSGEPLTRVARQLWFEHAAPNGLRIEPLRRDHRQVSIDRTHNAGPTMAKFSCQVSPAIQPGETGVISYTCTGGQFIDAFYWRQDILRYTRHFTIVMRQAGGHRLLTCTGEQVQPNGLITSATEDLLWDYDGDDIVVTLTRDYLRPNESVTLRWEIDRDQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUR0</accession>
    <name>A0A231GUR0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-ISL3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043710.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40370">
        <property type="protein sequence ID" value="OXR40370"/>
        <property type="gene ID" value="B7C42_07536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="1">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="95" mass="10595" checksum="B853AACE1D3084D0" modified="2017-10-25" version="1">MVFSGLSMLIVDDVVDEGPRVVVRAKAAPVPAVCSRCGAESSKVHSYHHRTVADPPVDGRLVVVRVRVRRLVCPTPQCCRTFREQIPGLLERYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV23</accession>
    <name>A0A231GV23_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS-type transporter EfpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">efpA_5</name>
        <name evidence="8" type="ORF">B7C42_07421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40483">
        <property type="protein sequence ID" value="OXR40483"/>
        <property type="gene ID" value="B7C42_07421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="35"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="505" mass="52426" checksum="A88FCC43C1189431" modified="2017-10-25" version="1">MTSAIDLEKSRSDLPSRHSSGSAGRRGSHAMRWWVLAVLGVAQLMVVLDATVVNIALPEAQLDLGFSNADRQWVVTGYALAFGSLLLLGGRLSDLFGRRTTFIIGLVGFAVASAVGGAANGFEMLVVARVAQGVFGALLAPAALSLLTVTFTEPSERAKAFGIFGAVAGTGGALGLLLGGALTEWASWRWVMYVNLIFAAVALVGAVLLLAKHTAEHRPKLDIPGTVTVSAALFGIVYGFSHAESHGWSNGLTLAFLIGGAVLLGVFAWLQTRVEHPLLPLRILLDRTRAGSYMTVFVMGIGMFAIFLFLTYYMQLTLKYSPIMTGVAFLPMIAAMIASSTTVPSLLLPKIGPKITVAAGFLIAAAGMAWLTRIGLDTGYASHILPALILLGLGLGGAMSTAFQGSTAGVHHEDAGVASAMVNTSQQVGGSIGTALLSTIASSAAANYLSGRQPTQLAVAESLIKSYTTSFWWATAIFVVGAIAAAVLMPSTAPAPAEGEPVLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVC4</accession>
    <name>A0A231GVC4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40587">
        <property type="protein sequence ID" value="OXR40587"/>
        <property type="gene ID" value="B7C42_07396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="282" mass="32168" checksum="BFE41870F34CC222" modified="2017-10-25" version="1">MTTSIRMSPGQPVAEYDVAAHLDGSAAFFGAAANVIMQLSLAPVGYGVVESTVDSGKVMLHPVKRTRTTLTYLAVAMLGSDDERAAYRAAVNWQHRQVRSTAQSPVKYNAFDPKLQLWVAACLYWGSRDLYERMHGPMPEQEAEAFYRHAARFGTTLQMPQAMWPADRAAFDAYWNRQLAEVRIDPTIRAYFDDLVDLKMFPPPVRLPFKRFHRWVVAGLLPPNLRAQMEMPWTASDDRRLARLLHAVGAVEERVPKQLKMFPVNAYMFDMRIRRRLGLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVG4</accession>
    <name>A0A231GVG4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-invertase hin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hin</name>
        <name evidence="2" type="ORF">B7C42_07289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909782.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40604">
        <property type="protein sequence ID" value="OXR40604"/>
        <property type="gene ID" value="B7C42_07289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="68"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="28607" checksum="4FD2C8E50BCCAC9D" modified="2017-10-25" version="1">MSACAAPAGSPCRTGTGKVATQYHTVRFRLVPALAKALSVTTPAIRNPGRAWIELPRPAALSAPAGHARIGYARASTLRQSLDTQLDALTAANVSRVFSEKISTRATHRPELDAAVTLCRELRASGVAVTLVVHEHKRLGRGIDLAALADNLKSADIGLEFLTGELQGSHDPAGVVFTVLAALSGMEREYIRDRTLEGHESARKRGKTIGGAHVTDPDMLAMALHLRDQQLSLRDIAARLVITTGTKKGRQPSPATVMRMLHDHDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVI0</accession>
    <name>A0A231GVI0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909816.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40640">
        <property type="protein sequence ID" value="OXR40640"/>
        <property type="gene ID" value="B7C42_07325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="12"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="352" mass="38571" checksum="B61E0DF3A0A5B843" modified="2017-10-25" version="1">MPIVADHYRFVVGVDTHAATHSYAVVESLTGRIIDQATFPTTTAGLARAQAWIGRRTDSEIDTVLIAAEGTGSYGAIAADRLEHAGYRVVEAPTPSAKRLRDNGKTDTLDAVTAARSTIVTDLYDLRDRRRGQVRAALNILTVARDQMATERTRTVNTLTALIRSYDLGIDARRALSAAQITEVASWRRRDEPIGLAVARAEAIRLARRINELGDQLKTNRAQLDEILAEHAPQLLALHGVGAVTAAVILTVWSHPGRIRTEAALAKIAGTAPIPASSGNTTRHRLSRGGDRQLNRAIHTIVLTRLRTDPNTRAYLQRRLAAGKTKREVTRCLKRYVTRQIHRTLTQANATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW41</accession>
    <name>A0A231GW41_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40785">
        <property type="protein sequence ID" value="OXR40785"/>
        <property type="gene ID" value="B7C42_07068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="85" mass="9130" checksum="C3C94B28EFC8230F" modified="2017-10-25" version="1">MTLPIARDLASVNIRVVTIAPGLFHTPLFATLPEEAIKALGAQVPHPARLGDPAEYAALARHIVENPMLNGETIRLDGAIRMAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWT1</accession>
    <name>A0A231GWT1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41038">
        <property type="protein sequence ID" value="OXR41038"/>
        <property type="gene ID" value="B7C42_06808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="22046" checksum="C329ED4642FDDBE0" modified="2017-10-25" version="1">MRTLLDLVLPQYCGGCGSAGAGWCEDCAAALSAEPMRVWPRTDPGVPCWALSGYAGPARRAVVAAKESGRRDLAAPLGRALARGLGLLRAPGRPLILVPAPSRRVAARRRGGDPVLRTARVATGWLSDCHLAPVLWARGGVRDSVGLSARARRDNLAGRIAGRIDASSVLVTLAAADIVLVDDVLTTGATAAESVRVLAAAGVNVRAVMVTCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWU4</accession>
    <name>A0A231GWU4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glutamine amidotransferase</fullName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776927.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41083">
        <property type="protein sequence ID" value="OXR41083"/>
        <property type="gene ID" value="B7C42_06853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="251" mass="27035" checksum="B307775F6F0558EC" modified="2017-10-25" version="1">MKPLIAITGRRISATTLVGVDGRWAACRADMFWAEFGMKIAEAGGIPVLLPYESAGPEVMSRVDALVLTGGQDVDPELWGGPPPTPNSTGGEVLTIDRRRDDYEIALVRHAIARGKPILGICRGHQVLNVALGGTLIPDLPDQGIEHYSLAAVPDRRPDREHRVDFDAGTLAAKLYGPRSAVNSWHHQAVDRPGEGLVVSGRAPDGVVEAIELPGRPVLGLQWHPEAIVDLDPCFPWLVEQALPQRLGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX32</accession>
    <name>A0A231GX32_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036509625.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41174">
        <property type="protein sequence ID" value="OXR41174"/>
        <property type="gene ID" value="B7C42_06770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="89" mass="9450" checksum="C65B253D5E39F7D2" modified="2017-10-25" version="1">MGSQLGYILFNILQFVRWAGIIIIAIAGMTLLISEGVKSKLSPGKVLGVAASAIVAAILFWILPTVVNYARVDSNRIVPDQPVGGVYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX85</accession>
    <name>A0A231GX85_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(R)-2-hydroxyisocaproyl-CoA dehydratase beta subunit</fullName>
            <ecNumber evidence="2">4.2.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hadC</name>
        <name evidence="2" type="ORF">B7C42_06641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.157" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41243">
        <property type="protein sequence ID" value="OXR41243"/>
        <property type="gene ID" value="B7C42_06641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="43457" checksum="FF3947320BB072F3" modified="2017-10-25" version="1">MSELDPTVMSALRAVTDDPTTYAQGWKARRGGMAIASFPMNFPAELVHAAGALPVIIQDDPTPITEGRSLLAEFYCGYTRSVADQAARGSLDIFDAFVAADHCVQLLGAVDVIRWARPDKPVHFAQFTSAMDDAWTKPRVEGRIEELKQEIEKVLGTEITTSALAASIALFNENRGLLRGLYDFRRSGRARITASDMQVLIKSSMVMDIEEHTALLERLLTQVDPAAQPRADLVRLHLSGHFCHAPRPEILDVIEESGALVVDDDLYTGFRYISTDVPQAGDPLQALSQWYLDRNRTAPCPTRVTTDVDWDTYLIDSLRRSRSDGVVVLMAKFCEPHMLYYPELRKALEAHGIPLLLLETEHEGNPVETLRTRVETFVERVRRQPAAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXJ1</accession>
    <name>A0A231GXJ1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_06496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41353">
        <property type="protein sequence ID" value="OXR41353"/>
        <property type="gene ID" value="B7C42_06496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="6">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="241"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="364" mass="39058" checksum="8D3BA277DC087A46" modified="2017-10-25" version="1">MSEVTVDQATADQAAAGEATADAAAYTRSLVGYAYRAEDYYEVGREKIREYARAVQDYGSVHWREADAAQCGYGAVVAPPTFLSIPAMLANRRLFERVITGYDVYVQTDQVFEFHRPVVSGDRLVSDVEVTAVRTIAGKDLITVTNTFTDQFDEVVHMMHTTAVGVTGEDIDAGIAGAIERVIMHGVGAPSAAQGLSEAELLDAAVAPRRDHRFSEVSRTRVPHTVVRFDQVSVGDELPPRTARITRGDLVNYAGVSGDANPIHWHDGVATLAGLPDVIAHGMLTMGLGAGFVTGWLGDPGALIRYAVRLSNYTIVDARSAGVVEFTGRIKSVDHRSRTAVVVVVAKSAGRKIFGLATAEVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXN6</accession>
    <name>A0A231GXN6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780453.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41370">
        <property type="protein sequence ID" value="OXR41370"/>
        <property type="gene ID" value="B7C42_06513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="529" mass="58697" checksum="3377CDB52D7300A0" modified="2017-10-25" version="1">MSRRVTDNGRSDALGGGSSDERSRSVAGARHVHTLIVGSGFSGLGLAIRLSQQGRDDYLVLERGNDVGGTWRDNTYPGAACDVPSQLYSYSFALNPNWSRSFSKQPEIQSYIQGVADRHGVRDKHIFDCEMTGARWNEERARWEVQTSQGAFTADILVSAVGALCEPNLPDIKGINGFQGRIFHSARWDHEADLTGKRVAVIGTGASAIQIVPSIAPKVAHLDVYQRTAPWLLPRIDRPYTLPERLAFKYVPGVQKLSRAAIYAARETQVVGLAKFPPAMLALEGLARLKLRLEVPDPQLREKVTPNFRIGCKRMLISNEYYPALGRDNVDVVTDGIREIRANSIVTADGTEREIDALIVATGFHVTDSPVYETIAGRDGRTLTELFDEIGQQGYKGAAIHNFPNMFFLLGPNVGLGHTSMVYMIESQINYIADAIDTFDQRGLRTVEVRKDVQDSYNRDLQNRMSNSVWLNGGCASWYLDKHGNNTTLWPDFTFRFRKLTEKFDVAAYDTTRPADGAARPDLKVVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY17</accession>
    <name>A0A231GY17_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_06353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41462">
        <property type="protein sequence ID" value="OXR41462"/>
        <property type="gene ID" value="B7C42_06353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR41462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="432" mass="46895" checksum="4C7CAE72BCD864FA" modified="2017-10-25" version="1">MSLPEVSGRPHAGADGRSSAARAVEAAWRIEWPKLVAGLTRLVGDIATAEEFAQDAHLAALEQWPRDGIPPNPGGWLMLTAKHRAIDRIRRDATFARKLPMLGHDLLTEHTGAQPDTNDIEDDLLRMVFTACHPVLSQPARVALTLRMVGGLTTDEIARAYLVPETTVAQRIVRAKRTIAEKMVPYEVPSGPQLAERLESVLEVVYLIFNEGYAATSGENWVRAELCDDALRLARILTGLMPREPEAFGLAALLELQASRTGARSDTTKQLVLLPDQDRSRWDQLSIRRGFAALGRAHNLAVRRGVPPGRYALQGAIAAAHAMAATSDDTDWRRIAGLYAVLAERFPSPVVEVNRAVAVAMVHGPAAGLDLVDAVAATGALDSYHLLHAVRAHFLVQLDRPADARAAYLRAADLTANAAEQALLRDRAARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY41</accession>
    <name>A0A231GY41_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hca operon transcriptional activator HcaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hcaR_6</name>
        <name evidence="3" type="ORF">B7C42_06412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41520">
        <property type="protein sequence ID" value="OXR41520"/>
        <property type="gene ID" value="B7C42_06412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="32170" checksum="4642D35675DBED3C" modified="2017-10-25" version="1">MDGVELRHLRYFLAVAEELHFGRAAARLHIAQPALTQQIRRLETLLGARLFDRTSRTVALTPAGAVLRERAEALLGHAHRDLAEVSRIGQGGQGTLYLGFVPSVLPLEPLRGVRAFRDRYPLVEVDLVEGFTSHLMERLANGALDLAIVRDPDPQPGTTTTPLMTEPFVAVVPDDHPLAARDTVTGADLVDHPMVFFPRAAGSLAHDRNLAPLLRSGRRPRIVQEATNWTIILYLVAAGLGITVAPRSATFTAPASARIIALTETDADTTIYTAHRTGDERALVHNLLALLPGPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYP0</accession>
    <name>A0A231GYP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-substituted formamide deformylase</fullName>
            <ecNumber evidence="2">3.5.1.91</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfdA_2</name>
        <name evidence="2" type="ORF">B7C42_06282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.91" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41641">
        <property type="protein sequence ID" value="OXR41641"/>
        <property type="gene ID" value="B7C42_06282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="46"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="532" mass="54990" checksum="5FB5B46B21F2FE16" modified="2017-10-25" version="1">MSTQLLVGGRIYSSSSPDATAMAVTDGTVVWLGAERPGRALHPDAEIIDLDGAFVAPAFVDPHVHVTALGLQLTGLDLSQANSLAQCLDLVREYAAAHSGTIIGDGWDETRWPEGRPPTVEEIDAAAGPGRAVYLSRVDAHSAVASTALLDAVAAVRAATGYTAGAPLRADAHHLVREAALDGLDRTQRDRARATALDYAAAHGVVAVHECAGPQISGRTDVRELLAFEHGVRVRAYWGEAVTSADEARALVGELGVHGLAGDLFVDGSFGSHTAWLREPYADRDTTGVSYLDAAAIAAHVRACTEAGIQAGFHAIGDAAIDAVVEGFARVAAELGAPAVATRGHRLEHAELLDAGQIAKLAEYGVIASVQPGFDAAWGGTEGMYATRLGAERAAATNPFAAMAAAGISLAISSDAPVTALNPWEAVRAAANHRTPGHHISPRAAFAAATRGAWRAGGVRDGIAGTLVPGAPADYAIWDTTELVVAAASDTVQRWSTDPRSRVPGLPSLDGGAELPRCLRAVRAGVTIYYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ13</accession>
    <name>A0A231GZ13_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41854">
        <property type="protein sequence ID" value="OXR41854"/>
        <property type="gene ID" value="B7C42_06196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="40" mass="4495" checksum="27E765FFD787116D" modified="2017-10-25" version="1">MTDDRRVVFVMFDGMKTLDVTWPAEVFAEANRLGGTYSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ79</accession>
    <name>A0A231GZ79_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLP1_add_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41898">
        <property type="protein sequence ID" value="OXR41898"/>
        <property type="gene ID" value="B7C42_05882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLP1_add_C" evidence="1">
        <location>
            <begin position="408"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="495" mass="52977" checksum="49D246D8F75CCEB8" modified="2017-10-25" version="1">MTLDPRTPILVGGGQINEREGGCEPVDLIVYAASRAATEAGTARLLELVDSVRIVGLLSWRYRDPGALVAERIGATPRHTGYTGSGGSTPQVLVNQAAQDIAAGRCDVVLVGGAESWRTRMKLRAQGIRPHWTIQDDTVAAAPMLVPEVPMRSDTEKRAGLDRPAYIYPLFEQALRVSAGRSVDDHRAAIGALWSRFSEVAASNPHAWTQRVHTAAEIVTPSETNRWIASPYTKLMNSNNMVEQGAALLLCSVEVAARLGIPRENWIFPHAGTEAHDTYDIAERGALDRSPAIRHAGAHVLELAGIGVDELAHIDVYSCFPSAVQVAARELGLPTDDPARPLTVTGGLTFAGGPWNNYSTHAIATLATRLRRAPGSYGLLTANGGYLTKHAFGVYSSEPPRAGFRRVDVQERVDREPTVRAHPGYAGPGEVEAWTVVYDRTGNPEAGFVAARTPDGGRTLASTRRSADVEHLVSAEVTGAVVEIGADGDLRFGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZI6</accession>
    <name>A0A231GZI6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42000">
        <property type="protein sequence ID" value="OXR42000"/>
        <property type="gene ID" value="B7C42_05984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="210" mass="23482" checksum="FAEB72DF1CA1F1C4" modified="2017-10-25" version="1">MTHVSRSSLLALHAIRLGGFIGTHAVAGRYRMPADLAESHVRDFRERGWINRFRFGTDAGWSLTESGRAQNERQLADELSECGAKASVEDVYRMFLPLNARLVRACTAWQLTILPDGSMQDNDHRDAQRDRPILAELESLAQELVPLTNTLTERLARFAGYDTRFAAALALAADNPEMVTGTEHDSAHRVWFELHEDLIATLGIDRAQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZK7</accession>
    <name>A0A231GZK7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42020">
        <property type="protein sequence ID" value="OXR42020"/>
        <property type="gene ID" value="B7C42_06004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="269" mass="29352" checksum="BFD0B2A38D430F25" modified="2017-10-25" version="1">MDQMFSALGDGSRWRIVELLAERPRSVGELAEATGLRQPQTTKHLQTLARAGVVAVFPLGQRRVYALEAGPLRELARRLCEVAETAEAHAGERDVVARYRAAIDAETAAAQQDRWADGRTFTFERILSAPRGAVWRHWVDPDLLAAWWAPAPMRITECVLEPTPGGRAVLDYRDPEGQRYRSQGRVLAAEKNERLVFDLSVLDAAGAVAFTGRYSLTLTETAEGTRLHVALTITETTVDAVAFIAGIETGWAAVLDNLADAVGASTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZL0</accession>
    <name>A0A231GZL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782297.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42054">
        <property type="protein sequence ID" value="OXR42054"/>
        <property type="gene ID" value="B7C42_06038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="29545" checksum="16F5EEBA8CFFDA2D" modified="2017-10-25" version="1">MPPRQQQPSRQREIRTDIPHTARIWNYWMGGRQNYEVDRRVGSAATELDPGITALAAESRRFLRRAVGHLAGDLGIRQFLDIGAGLLATDNTHEVACGRNPAARVVYVDNDPLVLTHGRTLLTDPRATYLDADLREPDVLFARAADILDLDEPVAVMFMGVLGHCERIGELRGVVADSMARVCRGSYLAYWDGTTDSADFVRMCATYENVTAVPYFPRDHCELRSIFTGLELLEPGFVPLTRWRRPAGEPVPTVPVSGYGAVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZM8</accession>
    <name>A0A231GZM8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">accC_2</name>
        <name evidence="8" type="ORF">B7C42_05945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41961">
        <property type="protein sequence ID" value="OXR41961"/>
        <property type="gene ID" value="B7C42_05945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR41961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="452" mass="48350" checksum="39044785461FB37D" modified="2017-10-25" version="1">MFDKILIANRGEIALRVARTCREMGVPTVAVYSAADHDSAVVEFADEAVRIGPAAAKRSYLDAAAILAAAEITGADAIHPGYGFLSESPDFADACRAAGVTLIGPPADVMAELGDKQSARTLMAKAGLPLLPGSLDALEFDEAQALADRIGYPVIIKAVAGGGGRGMAVVHDGAEFARAYRDTRATARMLFGDSRVYVERYLDRARHVEVQVLCDSFGAGVHLGERDCSVQRRHQKLVEESPAPRLPDGLAARIGRSAVDGVLAAGYTGAGTVEFLLDSAGNYYFMEVNCRIQVEHPVTEMVTGIDLVAEQIRIAAGEPLAWTQDRIQPKGAAIECRINAENPAAGFAPTPARISEFTAPGGPFTRVDTHIRAGYSVPPDYDSLLAKVIVWAPDRDAAIARMNRALAEFRVGGERLCTTREFLLDVLDQPKFRAGTHTTALVEEMFEGTAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZS2</accession>
    <name>A0A231GZS2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sialic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nanT</name>
        <name evidence="7" type="ORF">B7C42_05689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782818.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42090">
        <property type="protein sequence ID" value="OXR42090"/>
        <property type="gene ID" value="B7C42_05689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="410" mass="43153" checksum="D2FE8C5AD98431F6" modified="2017-10-25" version="1">MRRSRWIVLGGCFLAYLFDALEIVLLSMALPTIRQDMGLTITQGGLLATATLIGIGVSSVLGGYVADNFGRKKALVASLLTFGAFTAAIAIAPNYETVLLLRFLAGVGLGAVWSVVSAYVVETWPEEHRGRAAAFVISAFPAGGAMAATVAGWFLPDWRLMFLVAGTAVTLPVAVVVLFFAESESWAAERAHTDTDVVSVRDVLGSSLRRRTVLGTVMAALALFGYWGATTWLPTYLTTERDLPSSSVATFMTVLNVGMFLGYNGFGFLADRIGRHRTIVLTLLGVSLTLPVYALTTHQTALLWMGPVFGAFTAFFGLFGSYLGELFPTRARATGAGFCFNVGRGVSALAPFILAGLATSIGFRGGLIVCAGFFALAALVALLLPRAGAGAEDVAAEPITDPRDGTPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H018</accession>
    <name>A0A231H018_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein YdfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydfJ_4</name>
        <name evidence="8" type="ORF">B7C42_05799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42200">
        <property type="protein sequence ID" value="OXR42200"/>
        <property type="gene ID" value="B7C42_05799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="209"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="745" mass="78361" checksum="8CB10A7137163523" modified="2017-10-25" version="1">MAAWLYRLGRFSFRHKWWVIATWVIAAVTVAGLVGALNPKFAKDFDLPGTDSGTATNQVEKYFPQVMEQQKHASTSILVAADDGIANHTAQIDALVADLKTLPEVADPQTVVDPVLAAQVNPAIAASVVGDNGKVGLIQVRQNIEIMDLKVDQKHQLQDILAKHDGHGLQVEATGSLMQVMETGGKAEMIGFAIAFVVMIVAFGALVAAFIPLVTGLVGVLITILLVTLSAKFLSVNETATGIVTMLGIAVSIDYALFIVSRYRSEVKRGGTRAEAAGRAVGTAGSAVVFAGLTVVIAVVALMVIGIPLITQMGAGAAVAVAIAVLAALTLIPALLGAVGRFAFTPRIPWIRHAEQSETVDTNGVRFGRAVVRRPLPFIVAGLAVLVLAALPMSKLELGLSMSSPDEARAMALLERGFGKGVNGPLLVMVHDSGGDVSRAADDAVAHIKTLPDVANAGTLTWVGNGTAQPNSGANTALIMVTPNSGPAEQATHDLMEQIRDYAPSVAHDGAELHVGGQTAIMSDLSAKLDKALIPYLIVVVGLAFLIMIAVFRSIWVPLIGTVGFVFSVLATFGVTVAIFQEGALGLIDNTQPILSFLPIFLIGVVFGLAMDYQVFLVTRMREEYIHGMSATDAIIAGYRHGARVVTSAAVIMISVFAAFMLAPDTTSKMLGFALAIAVFFDAFVIRMIVVPAVIALLGDRAWGLPRWLDRLVPNFDIEGGAVRNRGIDVEAEAVPAAEAVGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0K6</accession>
    <name>A0A231H0K6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">xseB</name>
        <name evidence="4" type="ORF">B7C42_05480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780580.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42281">
        <property type="protein sequence ID" value="OXR42281"/>
        <property type="gene ID" value="B7C42_05480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8411" checksum="14D3F009F180413C" modified="2017-10-25" version="1">MTDSDVTEIATFGYERARDELVNVVKMLEQGGMDLDDSLALWERGEALANRCEEHLAGARRRVEDALSRRGGDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H175</accession>
    <name>A0A231H175_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42557">
        <property type="protein sequence ID" value="OXR42557"/>
        <property type="gene ID" value="B7C42_05334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="456" mass="50987" checksum="01710E623367A63E" modified="2017-10-25" version="1">MTTVNTFAHQQKSNSVYLDIAANDHGDEKGALVHHALTRLQTADPDLVEIGPGGGAAVRYLASRLTAASRARLTLIEAPGVISHSLEEAMEAFAAVGTCQLVQGWAKDLSTLITDPVDVISASALMHEVYSYGGAYTGLHTMMRVLPTVIRHYGFFVYRDVYAVDAPTLHERVVHCYSSRSWLQFLRMFVPHYLAEGAHPYHHHDDEVVARQNSRIVPVADLDTHVCAVIEAPVGVFREVQRHYITLRDHVWRSGILGFKPILDGELSVDWVDFRSGHKRVHYTLTDSEMVSPHPDALLAVSERYSDHYVIDGDIFDAVTDAALMAFLSGAELADLRCEPTWRGWLAREGHETYAYLTADDLLTAFAVNSLEGRPDQDTVLMPVSVEDVFTRDRLYYNRFLAKRLANPLVDAKQLILFQNIPTHDAHTMQRALATLQQLCSKSNVARLHTAIHWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1G3</accession>
    <name>A0A231H1G3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776882.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42694">
        <property type="protein sequence ID" value="OXR42694"/>
        <property type="gene ID" value="B7C42_05030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="192" mass="19835" checksum="96867A2054747973" modified="2017-10-25" version="1">MGRALIVVDVQNDFCEGGSLAVAGGAAVARQISDYLAAHRDDYAAIAATRDFHIDPGAHFSERPDYVDSWPPHCRAGTPGADFHPNLDTSALDAVFSKGAYSAAYSGFEGSTDDAVELATWLRDKGVDAVDICGIATDHCVRATAADARAAGLTTRVLLNLTAAVSPETTATALDGLRAAGVELAGSLPTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1V6</accession>
    <name>A0A231H1V6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3152 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42822">
        <property type="protein sequence ID" value="OXR42822"/>
        <property type="gene ID" value="B7C42_05160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3152" evidence="2">
        <location>
            <begin position="148"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="355" mass="38152" checksum="DE1B1F2BA65E4B2C" modified="2017-10-25" version="1">MLAARAESAGAGRRDRQQTTEIPEFYDPLGLYSGYGHGDRSHQPLRAKWDPTGAHDAANRPRPERDTKKQSALGRFVSTYGWRAYALPVLVIITVLVVVDAVKGGTDTSGGSTPALGRLSQHTSKAGIIGAPPKGDGKFAGDPPSGALPAGGAFTETAAGTWHIVPGTSAQIGAGQEHQFTYTVEVENGVDTTSLGGDDSVAKMVEATLANPKSWTHDPRFGFRRIDTGEPDFRVSLTSRQTTKSACGFEIPIDSSCYNSDLGRVVLSEVRWVRGATAFEGDIGSYRQYQINHEVGHAIGYHEHQPCEIDGGLAPVMMQQTFGTRNNDIATLDPQGVVPMDGKKCRFNPWPYPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H230</accession>
    <name>A0A231H230_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Salicylyl-CoA synthase / salicylate adenylyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sdgA_1</name>
        <name evidence="4" type="ORF">B7C42_04789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42903">
        <property type="protein sequence ID" value="OXR42903"/>
        <property type="gene ID" value="B7C42_04789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="463"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="573" mass="61463" checksum="5CF8E55EEAA13052" modified="2017-10-25" version="1">MTIRRQAAIDGVVPWPDDIAAEYRKAGYWQDRSIGSYVEAQVAHRPDQVAVVDGATRLTYRRLWDRAASCAQALLDLGLAPGDRILVQLPNCWEFVALTLGCLRIGIVPVMALPAHRRHELTHLAAAAEAVALVVADTDRGTDLRHVAQQVAAEVPSVRAVLVHGESSAEPGRSAPEYRLADALTTTVAFDEAEYAPRGSDVALMLLSGGTTGLPKLIVRTHDDYACNILRCAEVSEFDSATVYLGTLPSSHNFPLACPGILGALFSGGRTVMLPSPSPQRALRTIDAEGVTVAAAVPAVAQVWIEHQREHAPMRGTTLRVLQVGGSRMPDELAARVEPVLGARLQQVFGMAEGLINMTRIDDDADVVVSTQGRPVSAADEILVVDEHGNPVPDGTPGALLTRGPYTPRGYFRAPEHNLRAFTPDGWYASGDIVIRRPDGNLVVAGRDKDMINRGGEKISAEEVENFAYQIDGVEMAAAVAMPDPALGERLCLYLMLRPGCVVEPADIEAVMEAAGAARFKIPERIESVAAMPMTKVGKIDKKALRDDIRARLARTAESTRSPGAECGTAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2A4</accession>
    <name>A0A231H2A4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42981">
        <property type="protein sequence ID" value="OXR42981"/>
        <property type="gene ID" value="B7C42_04867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="243" mass="26044" checksum="A1040C124D7651C4" modified="2017-10-25" version="1">MHFTSEQRLGDDVLEREFTLGEIPGILWTPVSAPAPTPLILLGHPGGLRRMYPRLAGRARHAVADGYAAATIELPGSGERPPSPAAEQARADLRRAVQAGVPVDDEIVDRLILPLADKAVPEWRATLDALLSLPGISGPVGFSGGVIGIAVRLAAVEPRIAAAVLFAGSYVPRSMFDEARQVTIPLLVLLQWDDEGNDRQQALDLFDALGSKEKTLHANMGGHTGVPQFEGDDGSRFFARHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2B7</accession>
    <name>A0A231H2B7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778413.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42967">
        <property type="protein sequence ID" value="OXR42967"/>
        <property type="gene ID" value="B7C42_04853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="155" mass="17066" checksum="6EEE9A6395E925FF" modified="2017-10-25" version="1">MTVSNDFQSGADRVAADEAEIRRQIGRVIDGLRAKDLEAVRRAYATDVVSFDVEPPLQHVGIAAKLDNWAKVFLFFDDVNYEIRDLTFTVGEDVAFGHGFARLHGTMKNGVANSGMWVRVTYGMRKIDGIWLIAHDQVSVPFDIAGGAGVVDLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2G4</accession>
    <name>A0A231H2G4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43039">
        <property type="protein sequence ID" value="OXR43039"/>
        <property type="gene ID" value="B7C42_04925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="20521" checksum="6EA2FC2500E92A2C" modified="2017-10-25" version="1">MYIEAVRADAARNIEQVLTTGARLLADDPSASLSAIAAEAGVDRRTVYRRFASRDELLAAVYQARYDAVEEAIASVRLREAPVAVALHRYVEAIIGVNRRWPVQTARLVADDTIRERRAPLIAEVDAFLRRATDEGLLRPGLPEGWVSTLLAQLMVNAAENLPQLDPARAADIVVDTLLRGVGTSAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2J3</accession>
    <name>A0A231H2J3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43073">
        <property type="protein sequence ID" value="OXR43073"/>
        <property type="gene ID" value="B7C42_04959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="237" mass="24878" checksum="A953E3B09E29BE3E" modified="2017-10-25" version="1">MTVGTAITIPTHIHGYPDLAFGGYVAGMLADRVGGEVRVDFRRGVPVRTPVQITDTESGSVLTDSDGTVLAEASPGSVELAVTPPPTWEEAVAASQDSFAAGRAIPDCYGCGTTNAPGRGLRLYPWRLRDQDLVAAAWIPDAELAGPGGHLTTENIWSAVDCPGGWAAIELSGMSPGGLTAALTTRRIGPVRAGEKYLVWSWPIAASGRKHTVGVAISTPKGDLRVLAEALWIEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2S6</accession>
    <name>A0A231H2S6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionyl-CoA:succinate CoA transferase</fullName>
            <ecNumber evidence="3">2.8.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">scpC</name>
        <name evidence="3" type="ORF">B7C42_04577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43155">
        <property type="protein sequence ID" value="OXR43155"/>
        <property type="gene ID" value="B7C42_04577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="262"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="401" mass="42459" checksum="85A2B6AB934C6BD4" modified="2017-10-25" version="1">MPTDTVAFTSLIRPDTTIAIGDGFGAPRELSEQLTAVAENTEGLRLVLGWMPVADPDLDPRAFADARTFMPGWGLRSAVAQGHIRFLPVRLSGTPALLHGPLRPDVLMATVVHTPSGYRFANEVSWQRAAIDGGARVAALVSRAAPVCAAGPVLPAERLTVVGETDHPPLNMPDEPVAPELERLVENLVRFIPEGARLQIGPGALGATVLRKLEVPVRIDSGLLPDSVVDLAERDLLIGTPVATYLAGGPRLREWVSGRDVLHPIEFTHDPGRLSASPLFAVNTAVEIDTDGQINVEGTERAVVGGIGGHHDYAAAAARSVGGLSIIAVPTTHRGRSTLVERLSRPVSTPSHDVDIVVTEHGIADLRGLDRPERTEALRAAWGSAGVREPDDSSETDSGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Y5</accession>
    <name>A0A231H2Y5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">E-cinnamoyl-CoA:R-phenyllactate CoA transferase</fullName>
            <ecNumber evidence="1">2.8.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fldA_3</name>
        <name evidence="1" type="ORF">B7C42_04624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.17" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43202">
        <property type="protein sequence ID" value="OXR43202"/>
        <property type="gene ID" value="B7C42_04624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043785">
        <property type="term" value="F:cinnamoyl-CoA:phenyllactate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="403" mass="43652" checksum="50798C9F80392CE2" modified="2017-10-25" version="1">MEPILEGVKVVELAAWTFVPSAGAVLADWGADVIKIEHPETGDPQRGLVNSGVVAGSTGVNHFIEQPNRGKRSVGLDVANPQGLEILYKLVEQADVFATNLLPGSQQRLGVDLDAIRARNPKIIYARGHGYGPKGPQADRGGFDLAAYWARGGIGDALAAGDGSYPPIQRPAFGDVFGGFAIAGGVAAALYRRERTGQASVVDVSLLGTALWQLGPDVVGSKVIGSNIPKYDLDEMPNPVTSIYRTQDNRFLALVLLQSDRFWPDLCARIGRSDLVSDDRFADARVRFANRRECTAELRRTFEAQPLEYWRKQLEDFDGVWDAFESALELHDDPQVTANGYLPKVTDANGNTFALAANPVQFDETPAALRPAPGHGEHTDDVLQELGLDWDRIIALKESGAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H339</accession>
    <name>A0A231H339_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative CoA-transferase</fullName>
            <ecNumber evidence="1">2.8.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43269">
        <property type="protein sequence ID" value="OXR43269"/>
        <property type="gene ID" value="B7C42_04691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="823" mass="87912" checksum="7AF66B3EBFAA7574" modified="2017-10-25" version="1">MVAASDAIAEQVLGQNISYEPTWELALSDITPSYDPPLLGVRVVDLVSGPMQNVGRLLIDLGATVVRVRLAGVTDDSGFGPVVGGIALGSAIAARGAGAVTIDPATDAGRSEWENVLAASDILIENTAPGSSAEATLAIPEITTTHPSLVVLSISDFGRDNDFSRWQATTPVIHALTSELSRSGLPGRAPLMPPGELPYDVAAAQAAFEALSMYVDRLRTGSGCRIDFSVLDGAMQALDPAYGMTGSASAGVPLSSLPRGRADERYKYPIIACKDGFVRICVLAQRQWRGMFEWMGRPEEFADPKYDKLLVRFKSPDLLPAIGRHFADKTRTELEQQGQEYGVPTASVLTPDEALATEQIRSRGFLREVELAPGVIVPVPAGAMEIDGARAWVDTPPETTAEQRPRGDILAARPRTRPGLPLDGIRVLDFGVIVVGGDTGRLFGDLGADVIKIENSAFIDGARGAQGPAGMTPGFAAGHRNKRSIGIDLRNPAGQKLVRQLVRSADIVLTNFKPGVMNSLGLDYGSLEDVNPGIVVVDSSAFGPTGPWSRRLGYGPLVRAATGCTARWVYPDDPGSFSDAITVYPDHVCARIGALGALALLIRRERTRLGGSVSVAQSEVMLGHFAPVIAAGHLLEGGLPQVDVLERDAPWGLFPAAGDDEWLAVTVRDDTDWAALCSAIGRTDLLDDEALSTAADRHAQRDRIDTALAKWTREHAPSDAMKLLQEAGVPAGAMLRGADLPDWAYCKQRGAFREERHPRGREPYVLENVQIHADPVAEPPYGPAPLLGEQTRRIAEDLLGLDEDQIDDLLRKGVLEIAVPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3E2</accession>
    <name>A0A231H3E2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782661.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43374">
        <property type="protein sequence ID" value="OXR43374"/>
        <property type="gene ID" value="B7C42_04241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="16469" checksum="B4031F87FC50515F" modified="2017-10-25" version="1">MTRPVLADTAWTDPACPVARTLDLVGDRWSLLIVRDAMDGARAFRDFQQATGIARNILTDRLRRLVARGILERTPGPSGRRHIYTLTPAGRDLFTVVVALRQWGERHAFGPAEEHSVLVDERGVPLPELRPASSSGGAVDSETTFVRKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3G7</accession>
    <name>A0A231H3G7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamide-nucleotide amidohydrolase PncC</fullName>
            <ecNumber evidence="2">3.5.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pncC</name>
        <name evidence="2" type="ORF">B7C42_04244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.42" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782659.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43377">
        <property type="protein sequence ID" value="OXR43377"/>
        <property type="gene ID" value="B7C42_04244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019159">
        <property type="term" value="F:nicotinamide-nucleotide amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="154" mass="15719" checksum="45DD24D95814A07C" modified="2017-10-25" version="1">MTEDAAERIAELAAAAGSTIAVAESLTSGKIAAALGAAPDAGQWFRGGVVAYSPEVKRSVLDMPDVPVVSRPAAEALAANVRKLLGASYSVAVTGVGGPEPSDGEAPGTVWFATASETAVTASRAEFDGEPEEVLEQTVRFALSCLLDRLTADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3G9</accession>
    <name>A0A231H3G9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2,3-dimethylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="7">4.2.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dmdA_1</name>
        <name evidence="7" type="ORF">B7C42_04255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.85" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43388">
        <property type="protein sequence ID" value="OXR43388"/>
        <property type="gene ID" value="B7C42_04255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006250">
        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01342">
        <property type="entry name" value="acon_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="6">
        <location>
            <begin position="540"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="668" mass="71303" checksum="1448F00E9544D361" modified="2017-10-25" version="1">MTGQQPHTDGPRTVAQKLIESHLVSGRMRPGEEIALRIDQTLTQDATGTLVMQELEALGLDRVRTELSAQYVDHNLLQTDDKNAQDHEFLLSACRRYGLWFSKPGNGVSHPTHMQRFGRPGVTMVGSDSHTPAGGSLGMLAIGVGGLEVALAMAGEPLYITMPQIWGVELTGELPPWCSAKDVILEMLRRHGVKGGVNRIVEYHGPGLAGLTAMDRHVIANMGAELGATTTVFPADDAVREFLRAEDRAADFTELRADEGASYDLDEHIDLSAIEPLIARPSSPGDVVPVREVAGEPVAQVVIGSSANPGLRDFAMAAAIVSGRQTHSDVSFDVNPSSREIFEDLTRMGATFELIRAGARIHQSGCMGCIGMGQAPAVGRNSLRTMPRNFPGRSGTDEDSVWLCSPETAAASALTATITDPRDLADELGLDYPVLELPAHASVNTAMLVAPLPEAEARTVELVKGPNISALPDFDPLPDVIEAPVLLVVGDNISTDDISPAGARALPFRSNIPKLAEFAFTRIDPDYPRHAAEISGTTGHVVVGGDNYGQGSSREHAAIAPRYLGLRAVIAKSYARIHWQNLANFGIVALEFADPADYDRIGVGDVLRIEGLRAALTAGSVVTAHDVTANVDIPLRHRLSERQVETVLAGGIIPRLAAAQAAREMSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3L4</accession>
    <name>A0A231H3L4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA</fullName>
            <ecNumber evidence="2">3.1.4.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cpdA_4</name>
        <name evidence="2" type="ORF">B7C42_04298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.53" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821285.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43431">
        <property type="protein sequence ID" value="OXR43431"/>
        <property type="gene ID" value="B7C42_04298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016538">
        <property type="entry name" value="UCP008292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008292">
        <property type="entry name" value="UCP008292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="12"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="27889" checksum="112F330F674922E4" modified="2017-10-25" version="1">MTGPERTDGVVRIAAVADIHLGADSRGTLRPAWERLPAEADVLLVGGDLTRHGTLDEARVVATELADPGVPVIAVLGNHDYHSDLQDDITALLCDHGIRVLEGTSTTVTVGPYSLGVAGTKGFGGGFAGKCASVFGERIMRDFASYTVDLADALHVALCGLDTDVKVALTHYSPCGDTLHGEPPEIYPFLGSYLLGEAIDTCGGADLAIHGHAHAGYERGTTPGGVRVRNVAQPVIRAAYTVYDLSVPERADGSGAPSESHEAARTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H448</accession>
    <name>A0A231H448_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gmk</name>
        <name evidence="11" type="ORF">B7C42_04430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779181.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43562">
        <property type="protein sequence ID" value="OXR43562"/>
        <property type="gene ID" value="B7C42_04430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="8"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="20810" checksum="F036B1BF79A6969B" modified="2017-10-25" version="1">MVEHTQKGRLVVLVGPSAVGKSTVVRCVRERLPELVFSVSATTRAPRPGEVDGRDYRFVTRADFDTMIEEGELLEWADIHGGLQRSGTPAAPVKAALAAGKPVLVEVDLAGARSVRAAMPEALLVFLAPPSWEELVARLTGRGTESPEVIERRLATAKTELAACDEFDIVIVNDDVTTACEQLVSLFVSTNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H458</accession>
    <name>A0A231H458_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042773.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43496">
        <property type="protein sequence ID" value="OXR43496"/>
        <property type="gene ID" value="B7C42_04363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="41250" checksum="48F15BCAC3CF4EAF" modified="2017-10-25" version="1">MLKPYKQVQRWFPALEPEHAVPAAAPGESDAVDDEAEPGAARYPHYIRDTEPEPFDIPFADEPATRRSEFVGGWTDWVGSHAPGPDDDYPVHEGEVLRLPRDAETGEGRTRGRRRTRAAGADGDDAEGSGARSPVDDFDERDDPDTDDLDTDDVDTPEWILPPRREHGDGGAGRIVRRAPGPASPALRDYIRPSRLRVALVLAVAVLLLAVAGGFALYLLRSGDDGKQSVAPLPVRPALGDEAPMLRLTSAFGADSGARVGSAAHCPTERSARVVRGAEVGGTDSGPDAIMWFQHAFYVERSAERAREVVAPNAAVSPAPIIQRGIASVPLGTEYCVRVVTVDENRYSVEVTERRPGATPATYDKQLVTTAVVGGRTLITGITAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H484</accession>
    <name>A0A231H484_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin--NAD(P)(+) reductase fdr</fullName>
            <ecNumber evidence="1">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fdr</name>
        <name evidence="1" type="ORF">B7C42_04542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43674">
        <property type="protein sequence ID" value="OXR43674"/>
        <property type="gene ID" value="B7C42_04542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="9971" checksum="469E8918DAD1F2C5" modified="2017-10-25" version="1">MTSKPEDGQHVDVLLIGGGVATAGTAEELRRRGFRGSSALAGREGDPPYHRFPLTEDYLRGFIVAHDRAVRLPEWSFENDIQSGCAPRFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4T4</accession>
    <name>A0A231H4T4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c biogenesis protein CcsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ccsB</name>
        <name evidence="9" type="ORF">B7C42_04037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43802">
        <property type="protein sequence ID" value="OXR43802"/>
        <property type="gene ID" value="B7C42_04037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="37"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR43802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="567" mass="62216" checksum="9690BFA2F513D4A5" modified="2017-10-25" version="1">MTATMTPPSTAAKPPRQSLPRRAFALLRNAWRGLTSMRTALMLLFLLALAAIPGALLPQRSLNPQKVDKYIADRGTLGPWMDRLQLFDVFSSFWFTAIYALLFVSLVGCIVPRVFDHYKALRTPPVMVPRNLSRLPHHAATTTDDTPAEAIEQARRGLRGWRTVVRDESDVRNGRPGEVTLSAEKGYLRELGNLVFHLALVGLLVAIAAGKLFGYEGNVIVVADGGPGFCTTSPAVFDSFKAGRVNDGTGLTPVCVRVKDFKADYLPNGQAEMFTANISYQTGDDLATDTWRDTTIQVNHPLRVAGDRVYLQGHGYAPTFTVTYPNGQKRTETIQWRPDDGATFLSSGVMRFDPPGGMYGSEDERRKNQIAIEGLFAPTALMHGSLLTSSYPGLTDPAVAIDIYRGETGLDTGRAQSLFSLDPEMIKQGRLTKQQRVNLRPGESATLADGTKVTFDGAQQYANLQVSHDPAQSWVLVCALTMMAGLLVSLVVKRRRIWLRAYPEGPDDDRSGERRTVVEMGGLARTDQAGWGGEFDRLLTRLLGSDRTDTGRPADQRPVARTESTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H568</accession>
    <name>A0A231H568_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mycofactocin biosynthesis glycosyltransferase MftF</fullName>
            <ecNumber evidence="2">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mftF_3</name>
        <name evidence="2" type="ORF">B7C42_04171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43932">
        <property type="protein sequence ID" value="OXR43932"/>
        <property type="gene ID" value="B7C42_04171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023981">
        <property type="entry name" value="MftF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43646:SF6">
        <property type="entry name" value="PTHR43646:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03965">
        <property type="entry name" value="mycofact_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="465" mass="50410" checksum="62145662951BF76E" modified="2017-10-25" version="1">MRHDRLPDGFGVRIDPRVRTYSGGRLLVGGSPTRLLKLAPEAAALIGDGYLEVTDPQSAVVARRLLDSGVANPRPRLLPSPEEVTVVVPHYNDAAGLQRLLSTLRGHSVVVVDDGSDRPVRIPRTRGRCRVTVLRHDSRQGMVAARNAGLQAATTEFVAFLDSDVVPRAGWLEVMLGHFSDPEVALVAPRIVAREPEASVLGRYESARSSLDFGRRETAVSSRGSVSYAPGAALLVRRHALLAEGGFDEQMRSAADVDLCWRLERAGWRLRYEPAAHVACDQPASFGKWFGRKVSHGAGAAPLARRHAGMVAPLSVPFWTIAATALLATASRAGILGGLATLLAALIRLRRVFAELDNPTRVAAIHLARGFSAGVWRIVSALCRHYWPVTVLAMIASRRIRRLALALAVADGLADWFTHRDTGGLDPVRYLMCKRLDDLAYGTGLWSGALRARNVAALRPAVPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5I7</accession>
    <name>A0A231H5I7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.345</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pimB_2</name>
        <name evidence="5" type="ORF">B7C42_03654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.345" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44098">
        <property type="protein sequence ID" value="OXR44098"/>
        <property type="gene ID" value="B7C42_03654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043750">
        <property type="term" value="F:phosphatidylinositol alpha-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="185"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="41989" checksum="727A704F33E0395D" modified="2017-10-25" version="1">MGRTLLITNDFPPRPGGIQSYVHSLALRMPPEDLVVYAPRWRGDSHQRFDAQQPFEVVRHPTTLMLPTPLVLRRAAKLLREHRCDTVWFGAAAPLALMSPALRRLGADRIVASTHGHEVGWSMLPGARQVLRVIGDHTDVVTYVSKYTRRRFAAAFGAQAALEYLPPGVDSTVFHPDPAARAELRARYGLGERPTVLCLSRLVPRKGQDMLILAMREIRRRIDGAVLVIAGGGPYEDTLRGLVRSLDLDADVVFTGRVPAAELAAHHTLADVFAMPSRTRGAGLDVEGLGIVYLEASATGVPVVAGNSGGAPETVLEGRTGTVVDGRDERAVADAVVGILSDRDAAARMGAAGREWVADQWRWDVLGGRLRTLLDPGAHSGAAGSDGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5R0</accession>
    <name>A0A231H5R0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44160">
        <property type="protein sequence ID" value="OXR44160"/>
        <property type="gene ID" value="B7C42_03719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023294">
        <property type="entry name" value="Tachylectin2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14517">
        <property type="entry name" value="Tachylectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tachylectin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Tachylectin" evidence="1">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="29131" checksum="F9AC46DB450F09CD" modified="2017-10-25" version="1">MTTVVGTAMYGIKPDGDLQWYRHDGVQNGGAYWTAGEGGKKISGGWDVYSTVFSGRDSGVIYAVKPDGDLQWYRHDGWQDGGAYWTAGAGGNRISGGWGSYDTVFSIGRGVIYGIKPNGDLQWYRHDGWEDGTARWTAGAGGNRVSGGWNIYDTVFGSYLGVIYGIKPNGDLHWYRHDGWVDGTARWTAGAGGIKISGGWNIYDTVFAGYDGAIYGIKPNGDLQWYRHAGWRDGTATWEAGEGGKKISGGWDIYRTVFSGDTYLHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5S1</accession>
    <name>A0A231H5S1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">nadA</name>
        <name evidence="10" type="ORF">B7C42_03748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44188">
        <property type="protein sequence ID" value="OXR44188"/>
        <property type="gene ID" value="B7C42_03748"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="353" mass="37509" checksum="551AA46F02002A20" modified="2017-10-25" version="1">MASTSLTTATTGPTTQAFAAQVIDGPDGFGGVEATPEWAQEIKRLARERNATILAHNYQLPEIQDVADHVGDSLALSRIAAEAPEDTIVFCGVHFMAETAKILSPDKTVLIPDQRAGCSLADSITADDLRAWKAEHPGALVVSYVNTTAAVKALTDICCTSSNAVDVVASIDPDREVLFLPDQFLGAHVKRVTGRENMHIWAGECHVHAGINGDELTEQARTHPDAELFVHPECGCATSALYLAGEGAFPADRVHILSTGGMIDAAKAARSNQVLVATEVGMLHQLRKAAPGIDFQAVNDRASCKYMKMITPAALLRCLTDELDEVHVDPETAALARNSVQRMIAIGNPGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H654</accession>
    <name>A0A231H654_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator NmtR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nmtR</name>
        <name evidence="2" type="ORF">B7C42_03173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775672.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44384">
        <property type="protein sequence ID" value="OXR44384"/>
        <property type="gene ID" value="B7C42_03173"/>
    </dbReference>
    <dbReference type="GeneID" id="66718515"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="120" mass="13004" checksum="DF132DB2A3092218" modified="2017-10-25" version="1">MGHGVEGRDRPIARLDSESAAHVATTLQALATPSRLLILSELRQGSRPVSELAEAVGMEQSAVSHQLRLLRNLGLVTGTRAGRSIVYSLYDTHVAQLLDEAVYHSEHLRLGLSDRPRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6H7</accession>
    <name>A0A231H6H7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">topA</name>
        <name evidence="11" type="ORF">B7C42_03155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44367">
        <property type="protein sequence ID" value="OXR44367"/>
        <property type="gene ID" value="B7C42_03155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="31"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="853"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="924"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="944"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR44367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="980" mass="107045" checksum="5626204E2738527B" modified="2017-10-25" version="1">MATRDRGASPTPDAASAGPDAAAAGRGRPLRRLVIVESPTKARKIAPYLGRGYTVEASVGHIRDLPRGAADVPAKYKGQSWARLGVDVDHDFEPIYVVSPDKKAKVSELKTLLRDADELYLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAADTRELDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRIVVQRERERIAFRSAEYWDIAAKFDAGGRESDEANPRIFGARLVTVDGSRVAGGRDFGSDGQLKTRNGVTVLDEAVARRLAAGLEKADFQVTSVESKPYTRRPYAPFMTSTLQQEAARKLRFGSERTMRVAQRLYENGYITYMRTDSTTLSESAISAARAQATQLYGPEFVHPTPRQYTRKVKNAQEAHEAIRPAGDTFATPGQLHARLDQDEFRLYELIWQRTVASQMADARGTTLTVRITGRAGTGEECVFSASGRTITFAGFLKAYVESVDEDAGGQSDDAESRLPALTEGQNVNATELTPDGHTTNPPPRYNEASLIKALEELGIGRPSTYASIIKTILDRGYVYKRGSALVPSWVAFAVVGLLEEYFGRLVDFDFTAAMEDDLDAIAGGREQRGNWLTSFYFGGDHGAEGSVARSGGLKRMVGERLDDIDAREVNSIKMFTDDQDRDIVVRVGRFGPYLERMVQNPDDPDGDPVSQRANLPDDLPPDELTPEVAEKLFATPQEGRSLGVDPETGHRIVAKEGRFGPYVTEILPEPEADLDAKKGAKKAAAPKPRTGSLLKSMDLSTITLEDALKLLSLPRVVGKDPESGDEITAQNGRYGPYLKKGTDSRSLATEDQIFTVTLDEALKIYAEPKRRGRQAASAAPLREMGNDSATGKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDERASELLADRRAKGPVKKAAKKTAKKAPAKKTAAKSTAKKTTATAKKTTAKKTAAKKAPAKKAAAKSTAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6P6</accession>
    <name>A0A231H6P6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44396">
        <property type="protein sequence ID" value="OXR44396"/>
        <property type="gene ID" value="B7C42_03185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="378" mass="40869" checksum="AAAF9497407720B2" modified="2017-10-25" version="1">MTGSGDPADGRTADDAVVAGREATDVAKNASAKRSVLAGSVDWQLAARAGSAVVPSGPRTTRYSAEQVVEELSEASVRAESPVREVSLLLDDQPVPQATIVDRRGWIRAAAESMSELTGSADDDRGRFAGKPAGVQAGAMLAFLSTAILGQYDPFSGPDGTLLLVAPNIMAVERALGVSPSDFRLWVCLHEVTHRVQFSSAPWLADYMKQNVDTLGAVGDESVNEVLTRLLEEMRRRRDNGVSDDPADRGILGLLRATQPPPQREALDRLLMLGTLLEGHADHVMDAVGPAVIPTVAQIREAFDQRRRRPANPIQRLLRALLGVDAKVAQYVRGKAFVDEVVGKVGMQRFNTVWTDADTLPRPDEISTPQRWIDRVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H705</accession>
    <name>A0A231H705_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Salicylate synthase</fullName>
            <ecNumber evidence="3">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mbtI</name>
        <name evidence="3" type="ORF">B7C42_03433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44639">
        <property type="protein sequence ID" value="OXR44639"/>
        <property type="gene ID" value="B7C42_03433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019996">
        <property type="entry name" value="Salicylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03494">
        <property type="entry name" value="salicyl_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="194"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="458" mass="48287" checksum="7AB3D0AE44FDBAEA" modified="2017-10-25" version="1">MSTTDERVRNGYGDGPGATGQLAPGTEVTGTAPAIAPADAMAALAAADRFGEYVGYEGPDGWVFAADPIGSIELDSGELRVEWEGRATVEPWQGRPAAVIDAALAALPLQGRNAYGWIGFEFCAWALGADAHVPARTTLAHLMIPRIEVRIDASGVRVSGATPRETAEIHELIAQASAQPPAPARPVDVTIDPTDYRGRVAEAVDEIRAGRYQKVILSRKVDLPFPVDVPQTYRLGRANNTPARSFLLRLGGLEAAGFSPELVASVDRHRVVTTEPLAGTRAFGRGETADAAAREELVGDPKEIVEHAISVQTSFGEIAAVAEPGSTAVSDFMAVRERGSVQHLASTVRGTLAGDKSAWDALEMLFPSVTASGIPKRTGVDAVFRLDHDARGLYSGAVVTVSAGGALEATLVLRAIYQTTEGAWLRAGAGIVSQSRPEREFTETCEKLGSVAPYVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H775</accession>
    <name>A0A231H775_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">purS</name>
        <name evidence="6" type="ORF">B7C42_03366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517414.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44576">
        <property type="protein sequence ID" value="OXR44576"/>
        <property type="gene ID" value="B7C42_03366"/>
    </dbReference>
    <dbReference type="GeneID" id="66718711"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="78" mass="8458" checksum="52172377C6C15858" modified="2017-10-25" version="1">MARVVVEVMPKAEILDPQGQAIAGALGRLGFPGVSDVRQGKRFELDIDDSVSDAELEKIAEALLANTVIEDWKVVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7G5</accession>
    <name>A0A231H7G5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4,5-dihydroxyphthalate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pht5_2</name>
        <name evidence="1" type="ORF">B7C42_03524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.55" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44730">
        <property type="protein sequence ID" value="OXR44730"/>
        <property type="gene ID" value="B7C42_03524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018796">
        <property type="term" value="F:4,5-dihydroxyphthalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="37780" checksum="EEE9625487C2509F" modified="2017-10-25" version="1">MSEPTLYVGTMPYETTQALLDGSVTFHGIRARLDTADLASDIFRRMVHDREFDVAELGLTVYLRTLDSEESPFVAIPAFPARIFRHSAIFVNTASGISRPEDLAGKTVGEFGMYGQDSGIWAKGILSDDYGLTPEQCRWVIGGLDRQMPPFDFVPHIHPAHVRVEQAPPGRSLSAMLERGEIDALISSNVPRCVMDESPHVARLFPDHEAVERDYYRRTTIFPIMHTVVLPRSLVASRPGLARIVYEAYLAAKNAGTDRYRTGRKLYQVRTMLPWTNALFDRNAELFPADWWPYGLDANRKTIDTFLRYHFEQGLSPRRLTCEELFVPELLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H834</accession>
    <name>A0A231H834_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45094">
        <property type="protein sequence ID" value="OXR45094"/>
        <property type="gene ID" value="B7C42_03051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="105" mass="11102" checksum="FDDE9EE442B42429" modified="2017-10-25" version="1">MPGSPGIAPDVSDFDALEVNPLSEHEKGGGREGLEGVVEGAKGKAKEAAGQVFGKDDLREEGKAQQSRAESQREAAQKEAEAEKHRAEAGVEEKRQQAFQGKDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8G9</accession>
    <name>A0A231H8G9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45026">
        <property type="protein sequence ID" value="OXR45026"/>
        <property type="gene ID" value="B7C42_02983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="187" mass="20215" checksum="48BA4AD78A1A38A4" modified="2017-10-25" version="1">MPAGSLPLMNRYAAWLRGIMPSNPNMRNEKVRAVFEGLGYEGVGSVLASGNIVFGSTETDIAAMESRIQTALQAELGIAGGTIIRSRDEVQKLVDSDPFPGLTHCRGTYLTVTFVKDRAGAAPPELPGDLESAVRIVRFDEPARALLAVIDNSVAGTPNHMAWMETVYGKDITTRTWLTVQKVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8U4</accession>
    <name>A0A231H8U4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KipI antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kipA_1</name>
        <name evidence="6" type="ORF">B7C42_02347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45222">
        <property type="protein sequence ID" value="OXR45222"/>
        <property type="gene ID" value="B7C42_02347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="5">
        <location>
            <begin position="43"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="362"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="673" mass="72707" checksum="18C4EF47BADF6979" modified="2017-10-25" version="1">MTTAAEIGTGTATLESDSADIEVLRPGMLTTVQDWPGRVGYWHVGVPPSGPMDDLSFRLGNRALGNDEGAAGLECTLAGPALRFRTATRVCVTGAPATVTVDGERIRQWRTVEVPAGGTLDVGAVQGPGMRTYILFVGGLDLPEYLGSTATFTLGRFGGGTGAALRAGDRLPLGEPTGTVGSGVPMAEQPVLTRRWELAVTEGPHGAPEFFTRADIDTILGTDYEVHFNSDRTGVRLIGPKPHWARSDGGEAGLHPSNIHDTAYSIGALDFTGDTPILLGPDGPSLGGFVCPVTVVAAERWKLGQLCPGDTVRFVPVRADRAASIRALGPARRADWPIVLSDGGDGDDGILARADADDTTTVTYRRAGDDGILVEYGDMTLDLALRARVHALHRHLLEYAEPAITELTPGIRSLQVRFDPDRLATPKLLRLLREAESALPAVTELVVPSRTVHLPLSWDDPATREAITRYMHGVRADAPWCPWNIEFIRRMNGLSTVADVFDTVFAAEYLVLGLGDVYLGAPVATPTDPRHRLVTTKYNPARTWTPENAVGIGGAYLCIYGMEGPGGYQFVGRTTQVWDHSSTGDAEDPWLLRYFDRIRWYPVSAEELLDLRADFARGRGALRAEEGEFRLADYRDFLSANAESIADFRAVQAEAFAAERDSWQAAGELHERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAB6</accession>
    <name>A0A231HAB6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA:oxalate CoA-transferase</fullName>
            <ecNumber evidence="2">2.8.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfdE_1</name>
        <name evidence="2" type="ORF">B7C42_01978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.19" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45686">
        <property type="protein sequence ID" value="OXR45686"/>
        <property type="gene ID" value="B7C42_01978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="360" mass="37888" checksum="63E36194C097C330" modified="2017-10-25" version="1">MSTHASPDPGSAGPLAGIRILEVGTMLAGPYATMMLADLGAEVTKLEPAGGDISRQVGDSYFASLNRGKRSIRLDPGSVEGRARLGELVANSHALLVNLKPSAIHRLGLTYASLREFNPAIVCVAITGFGLYGGDDPAFDYIVQAATGVAALTGDPAGPPTLPGYSSADNSTGLTAALGLLAQIVSGRGGQVDVCLRDVMLSQLNYHAAAYLNDGRRPQRRPFGAHSYYVPAQLFPTADGYLALFVTHDRFWKAFAAEAGVTGFDTMAERVSRRAEVLAVVTAALARDDARGWEVRLRPLGIPAAAVRTLPEALDATPEVVAEAGAYRLVASPIRIDGYTPEYGPPPQLGEHDSQEPVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAE5</accession>
    <name>A0A231HAE5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45934">
        <property type="protein sequence ID" value="OXR45934"/>
        <property type="gene ID" value="B7C42_02227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="13995" checksum="A8A3B33BF60F7F22" modified="2017-10-25" version="1">MIVILGLVILIAAVVAGVVGVVVNTGAGHALNGNFTAFGYHFTGSTGTLFLYGIVVGAVGMAGLSLLLAGSRRNARRASAARRELDATRRDAPIYYGPAATPDAPHTASQPVGGTQPATPKRGLGRMFGRGRSVHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAP3</accession>
    <name>A0A231HAP3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor AcnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acnR_1</name>
        <name evidence="5" type="ORF">B7C42_02210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45918">
        <property type="protein sequence ID" value="OXR45918"/>
        <property type="gene ID" value="B7C42_02210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="20912" checksum="D197FC675341B28A" modified="2017-10-25" version="1">MPKVSDDHLAARRSQILDGARRCFAEFGYEGATVRRLEEAIGLSRGAIFHHFRDKDALFLALAQEDAGRMAEVAANEGIVQVMREMLDNPAQYNWLGTRLEIARRLRTDPEFAAGWTQRSAELTAATLARLERRKAAGALRDDVPTDVLLSYLDLVLDGLIARIASGHVNENLTAVLDLVEASVRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAX8</accession>
    <name>A0A231HAX8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45995">
        <property type="protein sequence ID" value="OXR45995"/>
        <property type="gene ID" value="B7C42_02288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019719">
        <property type="entry name" value="DUF2599"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10783">
        <property type="entry name" value="DUF2599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="160" mass="16699" checksum="710A8DEC05CAEB17" modified="2017-10-25" version="1">MVSAVLTVAGCGGGDSASTESATPATTPAATLTSEATTGPTSVAPTTEPTTDPFAGSPLIDHTEWTDDPDGRRLHVYPSAAGRADQFPAALDRAWSEVLADSPDADSPGMYDQFECHWVWARMVAPNKPSWNLEPWRPAVGYQATVQAMCNPGGPDPAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBE9</accession>
    <name>A0A231HBE9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-methionine-sulfoxide reductase catalytic subunit MsrP</fullName>
            <ecNumber evidence="4">1.8.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrP_1</name>
        <name evidence="4" type="ORF">B7C42_01156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.-" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46191">
        <property type="protein sequence ID" value="OXR46191"/>
        <property type="gene ID" value="B7C42_01156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="248"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="521" mass="55167" checksum="9C89FF8E50A7A632" modified="2017-10-25" version="1">MIETGTRGPTAHRGTLGFAAAALAGVLAGAAVLGIGELVGAILDPRSSPFFAAGATVVDHTPRQLREEAIRRFGSHDKDVLFAAMGAAMVALSALCGVLERRRRIGSAVFAVLGIAIAGAALRRPDAQWWYAIPTAAGVVAGLIALRLLLGSAGIPVHADPSDGIRLGRRRFLAMAAGVGAIAVGAAAAGRFVAQRLRDVAADRSRFVVPKPVSDVAPVSPAMTRSVPGLTAFVTPGTDFYRVDTALQVPAVSSAEWRLRIHGMVDRTVEFTMDDLRRRPAIARMITLTCVSNEVGGTLAGNAVWTGYRLADLFHEAGVHPDADMVLSRSADGFTAGTPIQAMTDGRDALLAVGMNGAPLPLEHGYPARLVVPGLYGYVSATKWVVDLEVTRFDRAQAYWTARGWAEQAPIKTASRIDVPAAFASLPAGPVVVAGVAWAQHRGIASVQVQVDDGPWHAADLTTEYSPDTWRQWTYRWQATPGTHTLRVRATDTTGTTQPAQRRPPMPDGATGRHSRTVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBK5</accession>
    <name>A0A231HBK5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46251">
        <property type="protein sequence ID" value="OXR46251"/>
        <property type="gene ID" value="B7C42_01217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="657" mass="67209" checksum="A46ADD9958961BF7" modified="2017-10-25" version="1">MAYSLALALVVVGPLLGPGYLLLRDGVSTPRSYATDAALGLGDAAPRAVPQDGLLAALSVVVDGGIVVKAILVLALAAAGWGAARLAHSLLRVSLAPQLVAATVAIWNPYVAERLLQGHWSLLAGYAALPWTVVLGQRLRSGAGQAHPATRTSHGDMASGPDDAGSTTAGADADRGPRTDTSEQAPGGRARPGWARTAVPWAMLGGVLAAAGLTPTGSLLAGLLAILTVGRRNVVGAVALWLVSAGPWLVATALSGSGAEPSDPTGVAAFAARAEPGLGTLGSLAGLGGIWNGDAVPGSRTTLFAVLSTLVLLAIVLSGVRAVAAPGERCTRYSRRMLLVLAAICILLPALGATGWGLSIGESLIERVPGAGLLRDTQKYVALAMPAYALCAAAGCRALASFRRRGVPEFARQPAPQTDTVHTDAPADSATAPTSPTAGSEPSRGDGTTLRPNTLAVQPLIAALCIAAIILTLPDLAWGVGGALRPVHYPPAWQRVAAVVDGPGDVAVLPAGMFRVFPYSGRIPVLDPAPRMLRSDVLQTGVLPVRGRVVAGEGARAQRVENLLLRGADPADLAAQGVGWILVEHRTPGAVGDARTTLSRLQPVYSDADLTLYRVPGAKESAKASTVSRTIALTAHILWSALLLAGLVSALIRYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBN1</accession>
    <name>A0A231HBN1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate 2-kinase</fullName>
            <ecNumber evidence="5">2.7.1.165</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">garK</name>
        <name evidence="5" type="ORF">B7C42_01247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.165" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46281">
        <property type="protein sequence ID" value="OXR46281"/>
        <property type="gene ID" value="B7C42_01247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043798">
        <property type="term" value="F:glycerate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="387" mass="39259" checksum="6207F915E4FF3E7B" modified="2017-10-25" version="1">MVRAKPWRVVIAPDKFKGSLAAPEVAAALAAGIAREAPDAEVRQVPVADGGDGTVDAFVAAGWERARVDTVGPTGAPHSASYAVRGSTAVVELAAAVGLVELPGGRTDPMGASTYGLGVLIRHALEHGIREVVLGLGGSASTDGGAGMLQALGLRILDEDGAEIGSGAAALARARRLDYAALHPAVREATFVLAGDVDNPLLGPDGAATVFAPQKGASPRQCAELEAILAQWAHLVDTSGHPFGTWGAHQRGADLAAHPGAGAAGGTGFGAMAVLGARQRSGIEVILELIDFAGRVRDADLVVTGEGAMDEQTLRGKAPAGVAAAAAGARVVAVAGRCTLSPERLRATGFARCYPLSDLEPDPGRSIAEAARLLEELGAQLARDYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBP8</accession>
    <name>A0A231HBP8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46364">
        <property type="protein sequence ID" value="OXR46364"/>
        <property type="gene ID" value="B7C42_01330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="93" mass="10195" checksum="7150787414F7B30B" modified="2017-10-25" version="1">MRVNGTAVKPAHQIKSGDEVRVRNAGVERIVVVVRLVVKRVGASIATQCYIDKSPPPPAPEIVAAMPKRDRGAGRPTKRERRETDRLLGRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBV2</accession>
    <name>A0A231HBV2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781707.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46360">
        <property type="protein sequence ID" value="OXR46360"/>
        <property type="gene ID" value="B7C42_01326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="323" mass="34667" checksum="EC5E3A98A5F8ACC3" modified="2017-10-25" version="1">MLRTRFTEMFGIEHPIVQGGMMHVGRAELVAAVANAGGLGFITALTQPTPDDLRREIERTRQLTDKPFGVNVTILPSINPPPYQEYVQAIIESGVKIVETAGSNPEPFLPYYKEAGIKVLHKCTSVRHALKAQKIGVDGVSIDGFECAGHPGEDDVPGLILIPAATKALDIPVIASGGFADARGLVAALALGADGINMGTRFLCTEESPVHRKVKEQIVAHTERDTELIFRTMNNTARVAANEISRKVVEIEAAGGKFEDVRDLVAGARGRRVFDEGDLDAGIWSAGQVQGLIDDIPTCAELISRIVDEAETLINSRLGSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC47</accession>
    <name>A0A231HC47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative inactive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46513">
        <property type="protein sequence ID" value="OXR46513"/>
        <property type="gene ID" value="B7C42_01483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011278881" evidence="3">
        <location>
            <begin position="45"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="450" mass="46682" checksum="9900A9BB4C85568C" modified="2017-10-25" version="1">MQLGDRAQRSRASGSPRRGGGGFRRIIALGAAACAGAALGCAAAGTSTATPVSEFYTPPAQFATTPGSVIKTEAMPVFVAPPGFGPWPANAQKVMYTSQTQDGAPTAVSGTYLDATAAWQGTGPRPTVVIAPGTSGQGDQCAPSQAFATGLYARITPPSISANQEAVSAMVWHALGARVFVTDYIGLGTPGVHTYVNRVEEAHAVLDAARAANALSGTGAQTPLAFWGYSQGGGATASAAELQPSYAPELNLKAVWAGAPTADLSAVLQKIDGNLIGGVVAYALNGFLERYPDLKPELDERVTPQGAGLLAELQDSCVGDVILKHPLLRGSDFTRDHRPILDNLREVPAAMDILDRQRIGTLSPTAPVLITSGVNDDTVPYPQARRLADDWCGKGATVTFRSNGLPPILPGMALPNHFGPEIIDGFSPSGVIPYLMDRLNDKPIAGCTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC61</accession>
    <name>A0A231HC61_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator VirS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">virS_1</name>
        <name evidence="5" type="ORF">B7C42_01253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46287">
        <property type="protein sequence ID" value="OXR46287"/>
        <property type="gene ID" value="B7C42_01253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="239"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="344" mass="37772" checksum="06C7A6A51CB4A6EE" modified="2017-10-25" version="1">MDKPVPAYNAVIVRCVLKTAADGLDIHALLRESGVPDSVLTSEYGMVTSSAYLRLWERAEFRQPAPDSGLRISTTYHLGKHGIFDYLFSTAATVGAGLDTVRRAGIAMATNHRYTVRTDELRGEQTLALELVEGDGRGAELTVQASFASTVARIRHGSGRQVSPSRITLRQKPPRSHRSFAEAFGTDRIDFDAPADTLTLRTADLNLPLPTADPALAQIVERYATMMATPLLCEPTWPDRVQRTLAHALAERDATLEAVARRLAVSPRTLQRRLAESGTTWRRELDLARRSVAGTVAETTTQSALAYRLGYSDARALRRAARRWKSDIAGETAMEGDLDSRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCK6</accession>
    <name>A0A231HCK6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plsC_1</name>
        <name evidence="3" type="ORF">B7C42_01518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775151.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46548">
        <property type="protein sequence ID" value="OXR46548"/>
        <property type="gene ID" value="B7C42_01518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="37"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="28456" checksum="D78956B07FBB9122" modified="2017-10-25" version="1">MEPVYRTIIGLARTVFFVQGLKFDVTGAENIPAQGGAVITINHTGYMDFTYAGLPARTPKRYIRFMAKKEVFDNPISGPIMRVLRHIPVDRGAGADSYKAAVDYLRRGELVGVYPEATISRSFEIKEFKSGAARMAVEAGVPIIPMTIWGAQRVWTKGHPKRLGRTNTPISIAVGKPIFPPAEADEKAVAELTETVRATMQDMLLGLQKDYPHEPGAYWVPARLGGGAPTREEADAMDAAEAKAKAEARAARRAAETGDADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCT1</accession>
    <name>A0A231HCT1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46720">
        <property type="protein sequence ID" value="OXR46720"/>
        <property type="gene ID" value="B7C42_01697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012963456" evidence="1">
        <location>
            <begin position="41"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="147" mass="15645" checksum="9BF8AA6033949D6E" modified="2017-10-25" version="1">MQGRVEVERNRNLNTRILAAGIVSGAVCAAVAALAPSASAQPFPAGVSCTETTCTNDTDETYLIEAWQHCRVVGGISETETPFNLVVRAHQTVRVEGVDCPPLVVERPDLIGGTDTTVLRTEPTRISYFKAVRHDPDAPKARTGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD01</accession>
    <name>A0A231HD01_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46648">
        <property type="protein sequence ID" value="OXR46648"/>
        <property type="gene ID" value="B7C42_01622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11680" checksum="C31808B75CBAC59C" modified="2017-10-25" version="1">MTENAPAEHVCVMAWDFERCWSVCGICGRIEPDEALSRGTVTERQEPMRIRYVGPRDTIGHFFAGDPVSSTLDDGSPWCVLELEMTEAVRREFEATQIEETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD18</accession>
    <name>A0A231HD18_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein B7C42_01782</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46804">
        <property type="protein sequence ID" value="OXR46804"/>
        <property type="gene ID" value="B7C42_01782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="112" mass="11253" checksum="B6937887D8A335A3" modified="2017-10-25" version="1">MEPGGQLDMQALLAQAQQMQQAVMAAQAEIAATDVTGEAGGGLVRVTIKASGEVQSLQIDPKVVDPEDVETLQDLVVGAVNNAMANAQQLAAEKLGPLAGGMGGGSVPGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDA5</accession>
    <name>A0A231HDA5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug-efflux transporter 1 regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bmrR_1</name>
        <name evidence="2" type="ORF">B7C42_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46802">
        <property type="protein sequence ID" value="OXR46802"/>
        <property type="gene ID" value="B7C42_01780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29869" checksum="51D50985ABC5E977" modified="2017-10-25" version="1">MPATVSIGEFSRLTCLSVKTLRYYHEIELLEPVSIDPGSGYRRYSTAQVEQAHLIRRLRDLDMPMPQIRAVLAAPDRSTRDAALAAHLERMEAELLRTRDVVASLRALLSPGAPIDVRYRLVPEFTAVTIRALVSRAEIGAWCGAAFPRLYDVLAVAGVAPGGPSGATYSADFFENEIGEVVAFAPLAADPGDAFDRHREIAVRRFPQRRFAIAVHAGPFTDFDRTYGALGSHVAEHDTALSEPIREIYVVGPQDCADPAAQRTEVCWPIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDF8</accession>
    <name>A0A231HDF8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46909">
        <property type="protein sequence ID" value="OXR46909"/>
        <property type="gene ID" value="B7C42_00023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012782387" evidence="1">
        <location>
            <begin position="34"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="90"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="541" mass="58822" checksum="1C2126BA3B7FFFBD" modified="2017-10-25" version="1">MTSRFTRRGFLAAGAGTIGALALAACGSGREGAQTGTAPTGAPVRGGTLVISDTQAVPSWQNQRLGTYSSGNLVFGVLVFLLYFDPVTKKLVPWVASEWSHNPANTEFTFRIRPGITFSDGTPLDAEIVRRNLERLARGDQARNITANPYLKPGFDHAELIADDTVKVVLTRPNQGFALRTSQLQNGIVAASTLELNVDDAGKPENVVSAGPFVFESQVPNQEVVLRRREGYNWAPQTSRNQGPAYLDKVVWRVLPEIGLRTGALQSGQVDIARGIQPIDEKALQRSGYQVLATRPTLGTSNFAAFRIGNPLVSDERVRKALQITINRDEMSRTALSANFPPAKSILNVDHPAFEDHSADLAYNPGRGRQLLDEAGWRAGADGVRVKDGKRLELTVPQDAQQAALGGAWEYIAQQWRQELGVVLNVRNDVTFANAAQTDPQVPVTVSRISVVSLAQQFGAPGNTALLVTDPELVAFRERELDAADDAALAQVQREEQKYLIDKALVIPTFEEAQVYGVSSKVNVEFNATTYPLFHTAWKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDG2</accession>
    <name>A0A231HDG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46993">
        <property type="protein sequence ID" value="OXR46993"/>
        <property type="gene ID" value="B7C42_00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="10637" checksum="4120DF1652C82ECF" modified="2017-10-25" version="1">MFPPGVGGGRGFFSITFASHTPVGEYLAVVMCDALGWHYRCPDENAGTWHETGLAAETDPTTAAHWFSDWFEVRAMTSRTPADAGRRSVSAQDAMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDK7</accession>
    <name>A0A231HDK7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">leuA_1</name>
        <name evidence="3" type="synonym">leuA</name>
        <name evidence="6" type="ORF">B7C42_01785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775479.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46807">
        <property type="protein sequence ID" value="OXR46807"/>
        <property type="gene ID" value="B7C42_01785"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="67"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="600" mass="66028" checksum="DA82F54C653BF689" modified="2017-10-25" version="1">MSPADAFVSGTRTITAPSKPAPADQPAWNQQKNSSMPAFRYRPFAEEVEPITLPDRTWPNQVVDRAPGWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEDGAIPDDVSIQVLTQCRPELIERTFEACQGAANVIVHFYNSTSILQRRVVFRADRDAVKKIATDAATLCLEIEQRYPDTNWRYEYSPESYTGTELDYAREVCDAVSEIIAPTPDKPLIINLPATVEMATPNVYADSIEWMSRNLARRDSIVLSLHPHNDRGTAVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGMNLFSRGVDPQIDFSDIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKSAADNADSDIDDIVWEVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLVLPRRLQIEFSQAIQKITDGEGGEVTPKEMWDVFADEYLNPILPLERIRQKMTAAETDSGTDTITAVVKVDGAEQEIVGSGNGPLASFVDALATIGYDVRVLDYSEHAMSSGDDAQAAAYVECAIGDKVTWGVGIATSITTASLRAVVSAVNRAQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDQ2</accession>
    <name>A0A231HDQ2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gdh_1</name>
        <name evidence="3" type="ORF">B7C42_00181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47061">
        <property type="protein sequence ID" value="OXR47061"/>
        <property type="gene ID" value="B7C42_00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036761">
        <property type="entry name" value="GDH_Mll4104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1633" mass="179641" checksum="D2AFB36846ADCD74" modified="2017-10-25" version="1">MTVSSELSSNAWAESLPEPLRGELATLESAYFRHVDAGDVDCAITGSSALVFRRHLELGLQRPAGTARVRVYHPDDGSGIGAAVQLVTDDMRLLVESVASALTRIGVTVSEVIHPIFEVMRDDEGRLHSAAPHEVDGNGVTGLRESWIHVQLHPSTSRDVLERIESEVPDVLTDVRQVIGDTEAMRAVQDRLAHDLIRTADAGTSPYPVVDLVDCAHLLEWLADGHFTLLGYARYQRRPAAGAETKSVVVPDSCLGVLRPNVGTDFQVPGNGGRRPLLMLTQGLVPATVHRSVYPYFVGVAESDASGTVVGEHLFIGVFTVAALHENVLDIPVIARRVRTVIEQCGFDLESFSGQAMLEVIQSFPRTELFSSDIDTMRRTASAVLSVGIRRQVRLFLRQDSYGRFVAAMVYLPRDRYTTRVRLEIQDILVRELGGESIDYSARVSENELASVYFTVHLPEPGTRVDTSETNRLRIQNLLAEASRTWDDHLRDEVARSTVLDPAVVQRYAAALPDGYKEDFEPSRALADIVRLERLDGGAIDQHLYRRPGAEPGSWRFTLYVGGGISLSQVLPLLQSLGVEVVDERPYEVEFGDGRMAWIYDFGLQARPDLLRMSLDRNMDAELVETADRLDVLHAQERGLRERFTEAFDALWHGRAESDPLNELVLRAGLPWRSVSILRAYSKYLQQADFPYSQANIARVLLASPDIAQLFVGLFEAMFDPDSASSDRADELRAAVRKRINEVVSLDADRILRAILGVVTATLRTNYYVVDADGRPREYLSMKVEPHAISELPRPRPQFEIFVYSPRVEGVHLRFGPVARGGLRWSDRLEDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPAPSGDPATDRQALQGEGVECYRTFISGLLDVTDNVDHASGEVIPPARVVRRDGDDTYLVVAADKGTATFSDIANDVAKQYGFWLGDAFASGGSAGYDHKAMGITAKGAWESVKRHFAEMNVDTQREEFTVVGVGDMSGDVFGNGMLLSEHIRLVAAFDHRHIFIDPDPVAGSSFAERKRLFGLARSSWADYDTSLISEGGGVWDRTVKAVPVSPQIRRALGLDEDVVSLSPPDMIRAILRAPVQLLWNGGIGTYIKASTESNGDVGDKSNDAVRVNASDLRVRVIGEGGNLGVTALGRIEFCKLGGKCNTDALDNSAGVDCSDHEVNIKVLLDGVVSAGELPVGDRNPLLSSMTDDVSDMVLRDNVSQNYLMGMSRTEAPRMLNVHMRVIEDLEQRRGLDRELEALPSTKELARRAEAGTGLTSPELANLLAHVKLSLKADLLDSDLPDSAYFAARLPKYFPAALRQRFGGAIKRHRLRREIVTTMVVNEMVDLGGITYAHRLNEEIGASATDVVRAFAATSQIFDLHSLWQRIRAADVPTAVKDELELETKRTLDRASRWLLSNRPQPVAVGAEIHRYSGSVRELAPKVPGWLRGHHLDTLTEASAEIVSRGVPEDLATEVFGLLNLFPLLDVVDIADITDRSGEEVGALYYALNEHLKIDWLLQAVSHLERGDRWHALARLALRDDMYGSLRSLTLDVLSAGDPEETAEEKIAYWESKNQSRLGRARAALSELFASGAHDLATLSVAARQVRSMVSGVGAQSEVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE53</accession>
    <name>A0A231HE53_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46987">
        <property type="protein sequence ID" value="OXR46987"/>
        <property type="gene ID" value="B7C42_00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="8993" checksum="D976E4B754AD7DCE" modified="2017-10-25" version="1">MFRNACVTCELILICQEMGEHDPLAHNESANAVPCNGAAIAMTSDVAAATSGQNFAIQAAMIPPWLWPRIATGRPEISWARIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEC1</accession>
    <name>A0A231HEC1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47047">
        <property type="protein sequence ID" value="OXR47047"/>
        <property type="gene ID" value="B7C42_00166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15529" checksum="697D4C5918EC2213" modified="2017-10-25" version="1">MTAQPDSSHDTPSRDGLEIVTELSRRFAAGDGAGALALFHPEIRIEQPASLPHGGSYHGHAGVAAMGESFGRHWERSIDNPRIFGSAESVVQLTTQTWTARESGRHATVDVVELFSFADGLVREIRVFQQDTHALLKTLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEE6</accession>
    <name>A0A231HEE6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="3">2.7.9.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppdK_1</name>
        <name evidence="3" type="ORF">B7C42_00324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821362.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47202">
        <property type="protein sequence ID" value="OXR47202"/>
        <property type="gene ID" value="B7C42_00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="73"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="268"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="384"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="709" mass="74302" checksum="8EA962790D04BBE7" modified="2017-10-25" version="1">MTAGAELAQRSETVVGLDGNCPLSRDRIGGKAWSINHMRGLGLPVPPAFVLTTDAWRDFTERGAIADDIWQAVCDGVAMLEHGTGRTFGSIRRPLLVSVRSGAAVSMPGMMDTVLNLGINDGVEQALAAATGSADYAADTHRRFRAQYRETVLQSPDGVVPADPWEQLRAAITAVFRSWDSVRAKAYRRNRGVSDDLGTAVTVQAMVFGNLDDASGTGVLFSRNPNTGDGPAYGEWLVGGQGEDVVSGRTTPRPLSELAATQPQVHDRLIAAAELLERDGRDIQDIEFTVESGTLWMLQSRPAKRSARAAVRAAVAMAEEGLITAAEALQRVGADQIRAVLQPATTAADAGEALARGESACPGLAFGVVVTDPDEAEARAAAGENVVLVRPTTSPDDLPGMIAARAVVTELGGTTSHAALVSRELGRPCVVGCGPGVVDALAGHSVTVDGGAGVVWAGEVAGGAVDGAVLDDVRRLAEWAAVAPDDLAGALAGDAEVVVAQAVVRTVSELELLRLIGVKGRVRGDAVAASLGGDADEVSARCADLVAGGLCADTPAGVRLTPDGRQRLGELLSAERGEVDTAAMAAAYEDFCVVNAELKEIVTAWQMKDAATPNDHGDAEYDAAVLDRLTELHTRVRPLAERLGSIAPRLARYRERLDTAVERIAAGDHTWVARPIMDSYHTVWFELHEDLIGLCGLSRAEEAAAGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEF5</accession>
    <name>A0A231HEF5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsfS</name>
        <name evidence="3" type="ORF">B7C42_00361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47239">
        <property type="protein sequence ID" value="OXR47239"/>
        <property type="gene ID" value="B7C42_00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="134" mass="14724" checksum="98D1307F9BD900CA" modified="2017-10-25" version="1">MTASAQAVEMAQVAARAADEKLATDVVVLDVSDQLVITDCFVIASAPNERQVNAIVDNVEEKLRLAGHKPVRREGTREGRWVLLDYVDVVVHIQHSDERNFYALERLWKDCPQVEVPGLEAPAQAQASGSGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEI4</accession>
    <name>A0A231HEI4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777099.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47252">
        <property type="protein sequence ID" value="OXR47252"/>
        <property type="gene ID" value="B7C42_00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="51"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="296"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="682" mass="76250" checksum="FA36CEBB88314962" modified="2017-10-25" version="1">MASYDEPITEQPLIETLDDMSPPRDALADISDAEIGANYLPISAGVVHKSSYPPIDDYAFLSDCETCCLIARNGAVEWMCLPRPDSPSVFGAMLDRSAGHFRLGPYGVNVPAARRYLPGGMIVETTWQTDTGWIIVRDALVLGPWHNNDRRSRTYRRTPEDWDAEHILLRTVKCVSGVVELEMSCEPAFDYHRAPANWEYTGEVYEQATATATCSHDELPCGELVLTTDMRLGLEGREARARTRMHEGDQLFVALSWSPLPAPRTFAEAAEKMWQTTECWRQWITLGKFPDHPWRGYLQRSALTLKGLIYSPTGALMAAATTSLPETPGGERNWDYRYSWVRDSTFALWGLYTLGLNREADDFFAFLHDVATAKDGEAQPLQVMYGIGGERDLDESEIPHLHGYDGARPVRIGNGAYQQQQHDIWGTILDSVYLHVKSRQQVPETLWPMLKRQVEAAIENWRKPDRGIWEVRGEPQHFTSSKVMCWVALDRGAKLAELHGEADYAEKWAALAAEIHADVLAHGVNDKGIFTQTYGGDTLDASLLLVVLLRFLPPTDPRVRATVLAIASDLTQHGLVLRYRTDTTDDGLSGAEGTFTICSFWLVSALVEIGEVRRARHLLERLLGYASPLKLYAEEIDPYTGRHLGNFPQAFTHLALINAVMHVIRAEHSTGAGEFHPAHPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEI9</accession>
    <name>A0A231HEI9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvH</name>
        <name evidence="10" type="ORF">B7C42_00526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503889.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47403">
        <property type="protein sequence ID" value="OXR47403"/>
        <property type="gene ID" value="B7C42_00526"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="18060" checksum="537522168F86FD99" modified="2017-10-25" version="1">MSTTHTLSVLVEDKPGVLARVASLFSRRGFNIESLAVGGTEVPEISRMTIVVTVEDLPLEQVTKQLNKLVNVIKIVEQDADASVARELILVKVRADASVRTQVIESANLFRAKVIDVSPDALTIEATGTRSKLEALLRMLEPYGIREIVQSGVVAVGRGPKSITATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEK7</accession>
    <name>A0A231HEK7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">27 kDa antigen Cfp30B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777037.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47155">
        <property type="protein sequence ID" value="OXR47155"/>
        <property type="gene ID" value="B7C42_00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="145"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="27782" checksum="A46E320B159B9866" modified="2017-10-25" version="1">MSYTFEPGDPCWIELFTADTDRAVDFYGELFGWTAESDEQYGGYITFRKDGNAVAGGMRNDGSDGAPDQWTVYLTSVDVHATAASAADHGGRVVVEPMAVGELGSMAVLADPSGAGVGAWQPGVHHGFGSFGIAGGGNWSGHVGYPSWFELHTPAYADALKFYREVFGWRDPFTVGDSPEFRYTTIHSATPMLGGVMDSAAYLPAGSPGGWRVYIGAEDVDATVKQVVSLGGSVESEPENTPYGRLAALRDPSGVAFSVGGNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEW4</accession>
    <name>A0A231HEW4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">smc_1</name>
        <name evidence="5" type="synonym">smc</name>
        <name evidence="9" type="ORF">B7C42_00628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47503">
        <property type="protein sequence ID" value="OXR47503"/>
        <property type="gene ID" value="B7C42_00628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013121991" description="Chromosome partition protein Smc" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="8">
        <location>
            <begin position="509"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="758"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="297"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="403"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="803"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1202" mass="130338" checksum="5BCE5C2DA9C57449" modified="2017-10-25" version="1">MHLKSLTLKGFKSFASATTLRLEPGITCVVGPNGSGKSNVVDALTWVMGEQGAKALRGGKMQDVIFAGTAGRAPLGRAEVTLTIDNSDGALPIDYSEVSITRRMFRDGAGEYEINGNSCRLMDVQELLSDSGIGREMHVIVGQGQLSAILESRPEDRRAFIEEAAGVLKHRKRKEKAVRKLDAMQANLARLTDLTTELRRQLKPLGRQAEVARRAATVQSELRDARLRLAADDLVARRRELESQQSKEAFAREQQITVQAELDGANAALAQQEFQLSRLTPGAEAAAQTWFQLSALVERVNATIRIARDRARNLTIEQPTGTGRDPEQLEAEADRVQAEEAELLEAVEVATATLEAARDQLLDREQAAKAAEQAHLAAVRAIADRREGLARLAGQVDTLRHRAQSADGDIARLSEALAAARQRGDAAEAEFESVQTELSELDAGEEGLDAAYEHAAQALELADARVTELRERDREAGKKVASLTARIEALTMGLARKDGGAWLLDNRADGLQGRLSGMVRVHSGFEAAVAAALGPLADAIAADAHPTAQAAVRALKDADGGRAAVVYGGAAQPRGEIGDLPAGVRPLAEVIDCPDPLRGAVAALTAGTVVVDDLTQAADILSRRPELRVVTRDGDLSGSGWVLGGSDRAPSQIEVQADIDAAAAELVSWQRQAEEVEAALSGALAEQNDRKQAVDQALLALHESDQALVAIYDRLGRLGATARSAHSEYERLLAQRAEAESARDENLTALAELEGRLRHAESEQSDLDSDADAGTDTAGQEREQAAAALAEARAMEVEARLSVRTAEERAESVRGKADSLRRAARAERETRARAERAQAARRRAAEVAAVVAESAERIAAELETVVGEAAARRDELVRRRTECAGQVDQIKERVRALSTQLTQLTDAVHRDEVARAQSALRIEQLETTIAEQFGIALDELVAEYGPHVPMPPTALEMQEYEQARERGDQVSPPQEMPYDRATQERRVKRAEKDLATLGKVNPLALEEFAALEERYNFLSTQLEDVKKARQDLLDVVAEVDARILQVFTEAYEDVEREFVQVFGRLFPGGEGRLLLTDPSDMLTTGIEVEARPPGKKVKRLSLLSGGEKSLAAVAFLVSIFRARPSPFYVMDEVEAALDDTNLRRLIGLFEQLREKSQLIVITHQKPTMEIADALYGVSMRGDGITQVISQRLRGENLVGATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF92</accession>
    <name>A0A231HF92_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mycofactocin biosynthesis glycosyltransferase MftF</fullName>
            <ecNumber evidence="2">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mftF_2</name>
        <name evidence="2" type="ORF">B7C42_00478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47355">
        <property type="protein sequence ID" value="OXR47355"/>
        <property type="gene ID" value="B7C42_00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023981">
        <property type="entry name" value="MftF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43646:SF6">
        <property type="entry name" value="PTHR43646:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03965">
        <property type="entry name" value="mycofact_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="102"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="454" mass="48459" checksum="EFCADE6F43C61993" modified="2017-10-25" version="1">MTVTLRPDARLRSSPDGRVLLGGSPLRMLRLSPAGARRVRAWFAGEPVGSDPGAQALAQRMLAAGVAHPTIDRGGHTIADVTVVVPVKDNPAGLSRLLAATGDVGSRIVVDDGSAVPITGDGEPSPTVTIVRHASARGPAAARNSGYRAARTELIAFLDSDIVPDPGWLDPLLPLFDDPAVAAVAPRVRTFEHGVLGSYEAHRSSLDMGGEPAVVRPGGRISYVPTAALVVRRSAVDQAGGFDESLRYGEDVDLIWRLVGDGKLVRYQPDSVVRHEPRTTLRAWLRQRYDYGTSAAVLARRHPGHLHCARLPRATALRWATVALGRPWLGLATAAAPVRQLRRLRAAGLPASMAATVVGEAELAAVHQLADALRRIWWPAALFGRRGRRLLLAAYLPVVVRAVTAGRDPRAGLLRIADDLAYGLGVWAGCLRTRTAEPVVPLLYRTDGDGDAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFG7</accession>
    <name>A0A231HFG7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_00570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47447">
        <property type="protein sequence ID" value="OXR47447"/>
        <property type="gene ID" value="B7C42_00570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR47447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="391" mass="39802" checksum="742B4233D70B3D35" modified="2017-10-25" version="1">MTTVTQVRATRRWTMLALGVFAQSSSAVIVHGTPFLLPALTDRGMPLATAGLLVAMPTVGLVCTLIAWGYIVDRVGERSVLVAGPVVMCVAGVAAATATNYGTLGVLLFLAGMGAASTNGASGRVIVGWFPVDQRGLAMGIRQTAQPLGVAIAAMSIPAVAAAHGFSTAILVPAAMAGVAAIGCLIGIVDPPRPASTGEHPDNPYRGDSTLWRIHAVSVLLVVPQATLWTFALLWLHRDAGLSLPVAGAIVTATQILGAAGRIGAGVWSDRVGSRLRPLHTVATAAVVSMAALAGAAWLHWWWAAIPILFAASVITVADNGLAFTAVAEIAGPYWSGRGLGIQNTGQNLASAAVAPIFGALITAAGFPATYLVAAIIAAAAVPMVPIARNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFL8</accession>
    <name>A0A231HFL8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dapA_1</name>
        <name evidence="9" type="synonym">dapA</name>
        <name evidence="11" type="ORF">B7C42_00799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779529.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47674">
        <property type="protein sequence ID" value="OXR47674"/>
        <property type="gene ID" value="B7C42_00799"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR47674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="31351" checksum="D062E41AE83C31DF" modified="2017-10-25" version="1">MTNGESTRTGLRASGTVGVAMVTPFTAEGKLDVDAGVALAARLVDRGVDLLAISGTTGESPTTTESEKFDLLHAVVDAVGDRATVIAGAGTYDTAHSIELARNAERAGAHGLLVVTPYYSRPSQEGLLAHFTAVADATDLPVTLYDIPPRSIVPIAPDTLRRLAEHPNIVAVKDAKGDLGAGAELIADTGLAYYSGDDVLNLPWLSVGAVGFISVIGHLVPERLVQLRDAYAAGEVTLARDINAGLLPVNRAMARVGGVALIKSSLRLLGMEVGEPRLPQLMPVGVNLESIVAELRLAGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFQ8</accession>
    <name>A0A231HFQ8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ffh</name>
        <name evidence="10" type="ORF">B7C42_00640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779826.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47515">
        <property type="protein sequence ID" value="OXR47515"/>
        <property type="gene ID" value="B7C42_00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="261"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR47515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="527" mass="55778" checksum="99925BA8DB68B5B4" modified="2017-10-25" version="1">MFESLSDRLTGALKDLRGKGRLSPADIDATAREIRLALLEADVALPVVRQFIARVKERAKGAEVSAALNPAQQVVKIVNEELIGILGGETRRLQFAKNPPTVVMLAGLQGAGKTTLAGKLAKWLKGQGHTPLLVACDLQRPGAVTQLQVVGERAGVPVFAPHPGTSIGGGDNALGVTAADPIRVAEAGIEEAKQKHYDIVIVDTAGRLGIDEELMRQAAGIRDAVHPDETLFVLDAMIGQDAVSTAEAFRDGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILGMGDLLTLIEQAEQVYDQQQAEEAARKIGSGELTLEDFLDQMLAIRKMGPIGNLLGMLPGAGQMKDVLAQVDDKQLDRVQAIIRGMTPAERANPKIINASRRLRIANGSGVTVSDVNQLVDRFFEARKMMAAMGRQMGLPGARRNAKGKKGKKGKKGGRGPTPPKGMRGGFPGMPGMPGGMPGMPAAGMPDLSNMPAGLDELPPGLEGFDLSKLKFPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG29</accession>
    <name>A0A231HG29_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsK_1</name>
        <name evidence="8" type="ORF">B7C42_00802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779521.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47677">
        <property type="protein sequence ID" value="OXR47677"/>
        <property type="gene ID" value="B7C42_00802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="7">
        <location>
            <begin position="497"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="514"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="862" mass="91962" checksum="86DF2810E0E4E5B2" modified="2017-10-25" version="1">MAGKSRGTTTSSSRAGSTRGRAPARTRSGGSRARSAPRGRTTATRRPVRRSPQTAPLAVIGRGIGNGWSVLARGFGATTRTISRAGEIEHGHRRDGIALALVAFSVVIAAAVWLSAGGPVGHWVDTAVRAIAGSAAAVLPFVASGIAVVLMRTEPRPEIRPRLVLGGLLVGLPALGIWHIFAGAPADAHGRAHAAGFVGYVLGGPLRNGLTAWLAVPLLLLAMLFGLLLVTGTTVREVPHRLRELFGLPDAEFADDDGQYGLYDPENYDADGFPVHKSRSSRRGRTPAENYPADEFGGADAVTEVLGEPPLRDAKDIAEADETPPPATKPKTRKAPKVVDQTPEPPPAQQLEFVTDREVDGDYQLPPLTLLTDGDPPKKRSAANESMIEAITEVLVQFKIDAAVTGFVRGPTVTRYEVELGPGVKVEKITALARNIAYAVATENVRLLAPIPGKSAVGIEVPNADRELVRLADVLKAPSTRNDHHPLVIGLGKNIEGEFVSANLAKMPHLLVAGSTGSGKSSFVNSMLVSLLGRATPDEVRMILIDPKMVELTPYEGIPHLITPIITQPKKAAAALAWLVEEMEQRYQDMQASKVRHIDDFNKKVKSGQITTPLGSERVYRPYPYILAIVDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQPGAEKLIGMGDGLFLPMGASKPTRLQGAFISDEEIQAVVDFAKNQAEPEYQEGVTTAKAGEKKDVDPDIGDDLDVFLQAVELVVTSQFGSTSMLQRKLRVGFAKAGRLMDLMETRGVVGPSEGSKARDVLVKPDELDGLLYSIRGGGEAEEAAEPDAIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSG1</accession>
    <name>A0A231GSG1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000443">
        <property type="protein sequence ID" value="OXR39563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39563">
        <property type="protein sequence ID" value="OXR39563"/>
        <property type="gene ID" value="B7C42_08369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="72" mass="7703" checksum="7F3D30A6291A4ADE" modified="2017-10-25" version="1">MFTDEELGKFGFKAYHIGDPVDGALLQADHPEYAELTPADLPGIKVLVDGRHVVDPAVWGDVEVIVVGDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSL7</accession>
    <name>A0A231GSL7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000136">
        <property type="protein sequence ID" value="OXR39616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39616">
        <property type="protein sequence ID" value="OXR39616"/>
        <property type="gene ID" value="B7C42_08317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="12055" checksum="94CA92A52535FCD4" modified="2017-10-25" version="1">MLRDVTVEDTRADLASFRGSKFQKVVFTGCNLAGADFQRVRFRSVRFEGCDLTGAQFSQASIEHNTTFADCRMVDVRGVRGLKGAHVRGDDLLGLAESLAREVGIEVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSR1</accession>
    <name>A0A231GSR1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-asparagine permease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ansP1_3</name>
        <name evidence="3" type="ORF">B7C42_08276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000099">
        <property type="protein sequence ID" value="OXR39657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39657">
        <property type="protein sequence ID" value="OXR39657"/>
        <property type="gene ID" value="B7C42_08276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="97" mass="10450" checksum="EBC280D348AA1144" modified="2017-10-25" version="1">MIGAPYTGYATLTFLVAVVALMACSSDPIQRWAVVATVCVMGPVLVGGWFLTRRKVLRIAAIRHDHTGQFPVVAERPWPGRPAEPQVIVEDPGPRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSS8</accession>
    <name>A0A231GSS8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_08249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000088">
        <property type="protein sequence ID" value="OXR39679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39679">
        <property type="protein sequence ID" value="OXR39679"/>
        <property type="gene ID" value="B7C42_08249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="192"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="421" mass="46855" checksum="705BE654B69221F9" modified="2017-10-25" version="1">MGGRLPKPVGTFGLPTKPKKQPNGRWRTTVRFYGASGSTQIERIGRSSDDASNRLAEAMRDFKEQLGYHRVTRNTKLIELAAELLSDLEADEAYTDGNVEDYRREIYVSTDKRANSKTVKIENSVGNLQVWQATTGELDRHLKRLVAAGLRRKAKQHKIILRAMMQIAVRHGAIDTNPIDGVSAFTRRTSRARGKVLDQDALPGFRAQVRAWAAGEAIPGTPAYTCGPPRDWSVVWVVDLICGTGLRPHEVFAVRLDDINLDADTPYLDVTGTLVEVKGSGTGGWVRKPFPKSVHGWRRMLLPEHAVQACREAMKDLEITGQPNPHGVLFPARNGSLRNPNNFGRVWRAARGENYAWVTPRTFRRVVATVIDNAYGDPERAARQLGNTEAVAKTHYIDIPETAPDNRAVLERWARGDGPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSY9</accession>
    <name>A0A231GSY9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000075">
        <property type="protein sequence ID" value="OXR39739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39739">
        <property type="protein sequence ID" value="OXR39739"/>
        <property type="gene ID" value="B7C42_08189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5759" checksum="10C0E0D9A3B26369" modified="2017-10-25" version="1">MQEQLVRYAETGEIDSVLVLTSDPDMAEIDWPRYLAVPLFIVLLAGRRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTJ3</accession>
    <name>A0A231GTJ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000051">
        <property type="protein sequence ID" value="OXR39936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782409.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39936">
        <property type="protein sequence ID" value="OXR39936"/>
        <property type="gene ID" value="B7C42_07999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="11833" checksum="45443E2A46DFDFC0" modified="2017-10-25" version="1">MTRENDRRAVLARVADEAEVLAEQLRFYEDCVISAPADRSYDYAVYMTDPYADEQEFDRRFDEYVAGMEASLARITRAVERFVAANRAELIELGIDYLPGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTM4</accession>
    <name>A0A231GTM4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000059">
        <property type="protein sequence ID" value="OXR39831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39831">
        <property type="protein sequence ID" value="OXR39831"/>
        <property type="gene ID" value="B7C42_08093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="187" mass="20305" checksum="532DC14D53F65F22" modified="2017-10-25" version="1">MEQIEKIAESIAASPGQVVAVEVGDRDRVADLVARLQPIYDYGYDADDGADVRLALGSACSTLERALEHFAAAMQLPYGAARTLWEFFEAVSQRPSAYRSCLVVADAAELLADEDELMWRALADELVDGPRCMGGGWDTLVLVDDHTGWASSRFGSAADAELAAKARLSSDEYAALQRGLELRYRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTW6</accession>
    <name>A0A231GTW6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782758.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40060">
        <property type="protein sequence ID" value="OXR40060"/>
        <property type="gene ID" value="B7C42_07864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="11922" checksum="B0ECCFD69F66F79B" modified="2017-10-25" version="1">MSIDAIGYVRSDVSGTHQKADEERLRAHAKCHGYNLKKTIVFGSHTDDPEHRLGVVLDRMDGVEAVIIPTVQHFDGDQVPDAISSRVDVVVVAPPTKLARLAQLARVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTY0</accession>
    <name>A0A231GTY0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000043">
        <property type="protein sequence ID" value="OXR40052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782766.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40052">
        <property type="protein sequence ID" value="OXR40052"/>
        <property type="gene ID" value="B7C42_07856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21568" checksum="5274628F49844D6C" modified="2017-10-25" version="1">MTALDELTRLLPPPAGAGRSFDWTAVEQRLGVTALPDDFKALLGVYGDVRFCNALRLYRPSTEPWLDLAEVTLAAREPLADTEFGEPPAEIPAGVSIDPATLIQWGGSFGGDYCLWDAHDPDPARWTLVFTDLDKLDWGFYPGTVTQYLLDWLTGRTAPIPLWGLDAVLPDGGTPFAETYDPTDFTGAATDRIDAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU00</accession>
    <name>A0A231GU00_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40097">
        <property type="protein sequence ID" value="OXR40097"/>
        <property type="gene ID" value="B7C42_07852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="75" mass="8254" checksum="FB2E6E360F420205" modified="2017-10-25" version="1">MDAKPRRTRLYVFPGGVLETADYGDDACGGVYLESRINALPQRVSGATDVPSPVRSMEPADAEMCERVLRLLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU05</accession>
    <name>A0A231GU05_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778480.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40100">
        <property type="protein sequence ID" value="OXR40100"/>
        <property type="gene ID" value="B7C42_07808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="DUF1593"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="DUF1593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1593" evidence="1">
        <location>
            <begin position="13"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="473" mass="52929" checksum="FDD57A5AA7917027" modified="2017-10-25" version="1">MNDETAHGPSKHRLVVLTDIKRGLENDDIQSMARLLLYANVIDIEGLIAVSSCWHRRGGRARDAAIIHSLIDAYSSVKHNLDAHATGYPDPALLHSRTFVGVPAYGNAPGDGFAEQRFSQNPGVQAILQILEDPDPRPVWFALWAGANTLAQALWIAEQTYTDRAFERLLGRLRIYAISDQDAAGHWLRDVYGERLFYIVSPSPASGGRFYRHATWPGISADRFSHGSEDGIRGGGFTGADRRLVSRRWLHRHIRRGSYGHRYPLHRFIMEGDTPSFLSLIPNGLNDPNRPDWGGWGGRYRRYIPDSAYAGRDETYPIWTNAADTVLGSDGNKHHSPQATIWRWRSEFQHDFAGRIAWTLTDNFADANHPPIARLAHHDNFTVVSGEKIELDASPSSDPDGDQLEFRWFFYAEAGDCPQPPHLTGADTPTASFTAPTTDVACELHVILRVTDTGTPPMSAYRRVRVRVEPLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUC1</accession>
    <name>A0A231GUC1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">atpH</name>
        <name evidence="7" type="ORF">B7C42_07734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40219">
        <property type="protein sequence ID" value="OXR40219"/>
        <property type="gene ID" value="B7C42_07734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="291" mass="31011" checksum="BB4982A4ABF12BC7" modified="2017-10-25" version="1">MTQVTGARPLRAPEFNTVKVGSMYAASREASSRAREALSAALTGSDSVAATTGSELFAVVAVLDDQRSLRVALADKSVSSSVRAELAERVFGGKISAATQAVLTTAVAQDWSRTRDLVDTLVLLGQEALLRAAADRGRIDAVEDELFRLGRTVEDNPDLEQALTDRGKPAAAKRDLLARLLTGKVEDVTMQLAEQAVGRSRGDVGVAFDQLSDLAASLRKQIVAHVRSATALTQQQREHLAASLQRIYDKPVTIHVQVDPALLAGVVVRIGDDVIDGSAVGRLQRLRQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV46</accession>
    <name>A0A231GV46_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline shock protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_07414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780090.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40476">
        <property type="protein sequence ID" value="OXR40476"/>
        <property type="gene ID" value="B7C42_07414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="171" mass="17312" checksum="07D3CFC8DFB7497F" modified="2017-10-25" version="1">MTSTTAGKGAENAKAEAGKDTGGGAGQGGAAAKAPARTSSALVSDQGTTAIADAVVQKIAGLATREVRGVHNLGGGAARAFGAFRDRIPGASASVGQGVSVEVGETQAAVDLEIVVEYGVSIAELARAVRRNVITAIEQMTGLEVVEVNINVNDVFIEEDEDQPPARERVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV60</accession>
    <name>A0A231GV60_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000031">
        <property type="protein sequence ID" value="OXR40513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40513">
        <property type="protein sequence ID" value="OXR40513"/>
        <property type="gene ID" value="B7C42_07452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="122" mass="13650" checksum="5B49234B9114EDAD" modified="2017-10-25" version="1">MAESDDITLWKHLAEESKAGRLDLDPSIAADCLKACEDQLDVYKECQSLVKQAEHVTGLGDFPASDQLAKMLSMKAVGGEGNFFDSLKEHIEVLSLIRDTIKYSVDRFTDQDHQNQQQIHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVF4</accession>
    <name>A0A231GVF4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780517.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40586">
        <property type="protein sequence ID" value="OXR40586"/>
        <property type="gene ID" value="B7C42_07395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23746" checksum="8188AB3C11E3DBA2" modified="2017-10-25" version="1">MTGSTKLSTRLLPLVRGAGPEDRNQTTVLDAALLAFLDFGIKRTSMVEVARRGRLSLATLYRRFAGKSDLIQAVGLWQARQFVEQVDAAVQRQIDRDASAEDQIVELFVAFLDGLRGNKLLDRLLTTEPEVVLPYLTVQGAPVIELGRDYVAEFITRLQTEGKLPHYDPLPLAELVARNALSLALTPQTLIPVDDEAACRRFARDHVVPGFRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVK1</accession>
    <name>A0A231GVK1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multicopper oxidase MmcO</fullName>
            <ecNumber evidence="4">1.16.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mmcO</name>
        <name evidence="4" type="ORF">B7C42_07287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909780.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40602">
        <property type="protein sequence ID" value="OXR40602"/>
        <property type="gene ID" value="B7C42_07287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="1">
        <location>
            <begin position="213"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="377"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="487" mass="52225" checksum="D4B1AB1D341ACC0D" modified="2017-10-25" version="1">MSRRDVLKLGGAAVVAGGAAAGCGRSPSATTADYTLRIAAGSVEVAPGKTVSTTLYNGQFPGPLLRLTEGTPMVVDVYNDTATPEQVHWHGQAVPAEVDGAAEEGTPFVPAHGMRQLSCTPGPAGYRFYHTHLAAGSDLTIGQYNGLVGPVYIEPASHPGAYDQEVFLTLKEFEPSLSQGGDMAADFLAGEPVPQLRDRGEAAMAASLASGAPHGYEVGYATFTINGRMLGHGDPIKVKQGQRVLLHVLNGSATENRSLALPGHTFTVIALDGNPVPNPVAVPVLWLGTAERVSAIVEMTNPGVWVLGDLSDDDRGNGMGIVVEYAGATGDPVWTAPPAFRWDYRLFADPRAHAPAAPDQVFDMLIEKRNAADGGFNVWTINGQRFTMSESSMQAQPMWQLERGKRYRLHLRNATDDIHPMHLHRHTFELTHVAGTATAGLRKDVAMLGGYQQMDIDFVADQPGLSLLHCHMQLHMDYGFMGLFDCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVS9</accession>
    <name>A0A231GVS9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40730">
        <property type="protein sequence ID" value="OXR40730"/>
        <property type="gene ID" value="B7C42_07154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="101"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="33356" checksum="DFDBA6D005B3C475" modified="2017-10-25" version="1">MTTGSTLPRRILARLLRDARTDAGIAVDTARKAIGVSGQTFWRMETGQPTRINPLFIRHLAELYKVSEETTDVLLALTEESQGKGWWHTYSEEIPKHFDFYVGLEDAAKRFSSYSTLLLPGLLQTADYRREVIWTEFPSMPTDEVERRIELSQRRQQRLRDKTNPLTVCALIDECTLRRLIGSREVMAAQLHHLIEIGSLPNVSVRVVPMQVGRHIGTIAGPFVLLEFPRHPTAKLTEPPVVYIQGFTGALYLEKPDEVRQYRNAYAEIQRAALDDGDSQNLIRTLMKELRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVY9</accession>
    <name>A0A231GVY9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA_2</name>
        <name evidence="1" type="ORF">B7C42_07190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40766">
        <property type="protein sequence ID" value="OXR40766"/>
        <property type="gene ID" value="B7C42_07190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="27702" checksum="9F8971147D9DFA8A" modified="2017-10-25" version="1">MTAMGGPDPSSAFPSVPSAAIPPRYRIRDLWIVRHGESRANAAFSAGADEAFPGSDSDVELTSTGYEQATRLGRWLAGLAPDRAPQLVVCSPYVRAQQTWATMARTADGITAGSGAVPAVTDERCRDREMGIFELHTPQAIRRRAPQEYERRARLGDWFYRPPGGESVADVALRMRDLLSELDRTTAERILIVAHDAVVVTAAHVLAGVGATPLDAPPPVPNASITQWRNDETHLRLAAWGLTPPGRDDAMPESDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWC3</accession>
    <name>A0A231GWC3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent urate hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpyO</name>
        <name evidence="2" type="ORF">B7C42_07054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40919">
        <property type="protein sequence ID" value="OXR40919"/>
        <property type="gene ID" value="B7C42_07054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="491" mass="53332" checksum="0B9BCB0CE837F8A1" modified="2017-10-25" version="1">MLRRFGPDPANWVQPSAADHDVVVVGGGQAGLGIGFALRRAGIARVSVIDAAAPGETGVWTTTARMVDLRTPKQWPEPEFGYPELSFQAWYESVHGEEAYESLTRIPRLTWARYIAWIETHLGVPVRHHTRLTDIEPGPDGLTLTLTVRRPDGTETTIQEITRKLVLANGVEGTGGPYLPPELGDIPASLLAHTGHHIDFARLAGKTVGVLGAAASAFDAAATALEAGAAEVHLFTRRPDLIVQGAGGAGPSGNLGARNNYHRRGDEARWRQRVLAARAGRSVPLESVRRATAFAGFHIHLDAPWSAATQAGDRVIVEAADGRHTVDFVIAGTGYQYDPRTRAELRGIAEDIALWGDRHHPGPDLADPALARTPYLGNGFQLTERQPGRAPWIGRIHIFSAAAHLSFGYPIGDTQSLAHHIPRLVDALGRDLYFEDQQSSPAPPPRHPPHRCAITIGTRSGHHNKRPSATWRSPSRSTMRLWQSPEGARWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD7</accession>
    <name>A0A231GWD7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Riboflavin biosynthesis protein RibD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ribD_2</name>
        <name evidence="2" type="ORF">B7C42_06909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779367.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40943">
        <property type="protein sequence ID" value="OXR40943"/>
        <property type="gene ID" value="B7C42_06909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="37"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="263" mass="27693" checksum="06005C7E54DCDBFA" modified="2017-10-25" version="1">MQRVPDAIQFTALTTDGAGEITDLVQLYTYPAALERPWIRVNFIASLDGAVTVDDRSGALGRPADATVFAILRDLADVIVVGAGTARVENYGGARTDSRRRMRLHHHGLGGARDGAPPPIAVVTASAALDPASRLFTDTQRPPMILTTAAADGERKRLLAETGAEVIEAGQSTVTAADIRRVLGERGLLRVLCEGGPSLFGELIGASAVDELCLTVSPLLVGGTAGRIAVSPNALPTPMSLRHALIDDDGTVLTRWERSRTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXB8</accession>
    <name>A0A231GXB8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator CynR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynR_2</name>
        <name evidence="3" type="ORF">B7C42_06737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41141">
        <property type="protein sequence ID" value="OXR41141"/>
        <property type="gene ID" value="B7C42_06737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="318" mass="34382" checksum="BF439D508D686DB1" modified="2017-10-25" version="1">MQNSGDSVQDTLPIIVIGATYSWPMELRHIRYLLAVADHGNFTRAAESLHISQPTLSQQIKQLERVLGVVLLDRSGRTVRLTDAGQAYARHARLALRDLEAGERAVHDVQDLSRGHLRVATTPTFTAYLIGPLVHRFRSEHPGISLTIRETTQDAIEADLLADRLDLGIAFAGAHAAGVEHTALFTEKLGLVVGSDHPFATAAQPLSAGALAGVPLGLLSADFATRLHIDRYFDECGVAPDIAVEANSISALLEFVRRGSLATVLPDAITRAQADLHPIPLNPPLPIRTVELLRRHTAYHSAAARAFTGAVHAIARDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXF9</accession>
    <name>A0A231GXF9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative succinyl-diaminopimelate desuccinylase DapE</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dapE_4</name>
        <name evidence="2" type="ORF">B7C42_06466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780505.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41323">
        <property type="protein sequence ID" value="OXR41323"/>
        <property type="gene ID" value="B7C42_06466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="171"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="366" mass="39459" checksum="A406318CEFA280AD" modified="2017-10-25" version="1">MTIDLRADPISITATLVDIPSVSRDEAAITDTVAWALREQTEGFEVLRHGNTVLARTNRGLPHRVIMAGHLDTVPIADNVPGRFETIDGEEVLFGCGSVDMKSGDAVFLHLAATVADPVCDLTLIFYDCEEIAAEYNGLGRIERELPEWLDGDLAILGEPSGGWIEAGCQGTLRVRLGLGGTRAHTARAWLGDNAIHKLAPVLQRLRDYVPREVDIDGCVYREGLSAVKVEGGVAGNVVPDEAEVLVNFRFAPDRTLDEATEHVREVFDGLDVSFERTDGAPGALPGLSAPAAKNLVQRVHSHGGGGVRAKYGWTDVSRFAARGIPAVNFGPGDPNLAHKVDERVPTRQITVVTEILRNYLTGHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXZ5</accession>
    <name>A0A231GXZ5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41487">
        <property type="protein sequence ID" value="OXR41487"/>
        <property type="gene ID" value="B7C42_06379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="54" mass="5995" checksum="0C0A9C5B09A81F49" modified="2017-10-25" version="1">MSERFDDQSRPANPEREDVSLSDSPVTNRKSPILLVVTMVIVLIVIVVLFVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY96</accession>
    <name>A0A231GY96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metallo-hydrolase YflN</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yflN_1</name>
        <name evidence="2" type="ORF">B7C42_06393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782549.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41501">
        <property type="protein sequence ID" value="OXR41501"/>
        <property type="gene ID" value="B7C42_06393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="24796" checksum="555A9B73D659F7D5" modified="2017-10-25" version="1">MSAIEQVADSVYVVAGTNVNWSLITGDSGVVLVDAGYPRDTGAVLDSLRQIGHEPADLAAILLTHAHLDHIGAIPTLVERTGVPVYTGADEAAHARREYLQQITPVDMARQLRTPGGPRWVFQTLRALGGHVGMSVPTATAYDENTLRQLPGGIVAVPTPGHTTGHTAYLMPGEGILFSGDALVTGHPLLPDTGLQALPEVFNHDEAQTHTTAESLIAQRPRLLIPGHGKPMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYC9</accession>
    <name>A0A231GYC9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41572">
        <property type="protein sequence ID" value="OXR41572"/>
        <property type="gene ID" value="B7C42_06213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="32475" checksum="032E4CDDC5DCCD79" modified="2017-10-25" version="1">MELVDEPESLLGIRQRNPLGARHNLQRRLSGAATMPVQVVGETLDRGRVEQIPHRHFPAQRELQPRAHPCSSQRVSTQGEEIVIESRSVSTQYLRERLGDDLFGARLWRPERRGGKHRCRQGLTVDLSRGGQRELVEHHDLRRHHVIGQPRAQPPTNGGDFEVGVRVVGVDGDSTISGGGQVEVSQSRGGPAVRVGRDDENGIEGAGARTPRDGDLISGDFAYAMQLFGGSGVGDDVGFRECVGSRQPIGERAFDEDIGDQSGAGDVGNAYGGGMFGDQLRLQPAQSRESGPRPSGCRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYK9</accession>
    <name>A0A231GYK9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41679">
        <property type="protein sequence ID" value="OXR41679"/>
        <property type="gene ID" value="B7C42_06320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="273" mass="29846" checksum="2207B3E116F2EA94" modified="2017-10-25" version="1">MQPSQVGLPPGTRRRQTAGLRREEVAALAGLSVDYYIRLEQGRDRNPSPEVLAALASALLLNSDEAAHLHRVARLAGTRSAAVAAPVETAGRGMVLLLESVRPTPAFVLDQVSNLLAANPEGLRLLWGIEEWEPVRRNLIRYVFTHPAARTVFEDWTGMARDCVAHLRVVQGAGSHPVELAALTDELCAATADFEALWAHYDVRAKRGTRRMFRHPAVGRMELTSEILTAADGQRFVAFQAEPGSPDRDAVTLLGLVGDDVPERGEGAEHEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ01</accession>
    <name>A0A231GZ01_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41805">
        <property type="protein sequence ID" value="OXR41805"/>
        <property type="gene ID" value="B7C42_06147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013076432" evidence="2">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="23079" checksum="A44705C195086C67" modified="2017-10-25" version="1">MSHRTIAALTAATAALTASVAIATAEPPAPSIETISGAVVLSGFAPGAFRAGPDGDVRVTVDGTPVATLPASFTVDGVAHRIDTRIGDGGRTLTMTPDIARRPAASAMENQLALNDFATIMSRGPVIGTVVGTVLGALVGAAVGASTCLVVGPGCLATIPAAVLAFAGAGGVAGTVLVGGGALAAGLWNYLTVLQAPPGQSSYAGQGGLLDPNGTGTPDAQLQLPSGSANGLGAGSASGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZB8</accession>
    <name>A0A231GZB8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsfB_3</name>
        <name evidence="4" type="ORF">B7C42_05924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41940">
        <property type="protein sequence ID" value="OXR41940"/>
        <property type="gene ID" value="B7C42_05924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="13700" checksum="3E8BF6F43354125D" modified="2017-10-25" version="1">MYTSVMYGGGEEMSVLVDDNGLSVEVDRTGGALVISAHGDVDAMTADQLQSVLDRMSEAFEDADQAAPVIDLSGVGFLGSAGLSVLHAAATTVTPRRLRVVASGAAKRVIQVTGLDRMVSVYDDLASAGVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZR3</accession>
    <name>A0A231GZR3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="2">4.3.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42103">
        <property type="protein sequence ID" value="OXR42103"/>
        <property type="gene ID" value="B7C42_05702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="312" mass="33651" checksum="9BC63B2AEF75FEF5" modified="2017-10-25" version="1">MSISVLRTTDGWWVSTPAGVARVDTTATSTGELLADRAALAAASVSTRLVPADSLSLVSPVTAPCRVVAQMTNFASHVTDAGGDPDTVPLTFFRKSSGSISGPFDEVIRPAHVRLLDYEVEIGLVFGRDMPVGTTITAENLADYVAGLVVTNDISARDVQLPKTQFYEGKSYPTFTPVGPALVLLDADELQRFTELRLRLSVNGEIRQDMTVADMIYHPVQTLQALTRFQHIAPGDLLLTGTPVGTAISAPPKPVEIIGSLLPAATKWRLFFKAQAKNRKYLQDGDVIEASVATDDGKIDLGRQRTVVRYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZY9</accession>
    <name>A0A231GZY9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator RcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rcdA_2</name>
        <name evidence="5" type="ORF">B7C42_05721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42122">
        <property type="protein sequence ID" value="OXR42122"/>
        <property type="gene ID" value="B7C42_05721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="226" mass="23400" checksum="E962B5503D684692" modified="2017-10-25" version="1">MTTRRHRPSAQARREALLAAAVEVTAAVGAAGVTHRAVTEKAGLPLTTVGYFFDSIDALTEEALRVYTDADADTQVALAEALAEAHSTPDEIAAALSSAATPRSPETPALFEAYLHAARHPEFRDAAARALDAARRAAAAGVRAAGSPEPDTAAPAFTALAHGLALHEMAVPGTLPPESVHAAFRALFLGFLLDNGHVELALRLRRQGEGDADSAEGDGQSAEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H008</accession>
    <name>A0A231H008_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42185">
        <property type="protein sequence ID" value="OXR42185"/>
        <property type="gene ID" value="B7C42_05784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="12012" checksum="1A5A88CCA94C3383" modified="2017-10-25" version="1">MTTTVTVIDEIAIPRDRVEEWSRRWRDDYLPGAGDRGMRVVRQCRRFTSPDTVTLEIQWELPGIYEFYGMRAAAGADDAVSSFWQWTDSLALSRARRVLEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H058</accession>
    <name>A0A231H058_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidase AmiC</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">amiC_3</name>
        <name evidence="2" type="ORF">B7C42_05720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42121">
        <property type="protein sequence ID" value="OXR42121"/>
        <property type="gene ID" value="B7C42_05720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="473" mass="50363" checksum="8F1D12BAB61151EF" modified="2017-10-25" version="1">MTSLHAFRDDALGEHDAVALAELVRDGSVSPQELAAAAIERARAVDPQLDAVACAIYDAPRYHSRSDAALYGVPTFVKDNSDVAGLPTNHGSEAFRARPAAKNGAYTDQFLGTGLTLLGKSRLPEFGFNATTEFMTEPPARNPWDLDRSIGASSGGSAALVAAGVVPIAHANDGGGSIRIPAACGGLVGLKPSRGRHIDGEQVRHVPIHMISEGVLTRTVRDTAAFVAAAENVWRNPKLAPIGEVLGPAQRRLRVGLLTHSVTGAEVDASTRAAVEHTATLLEKAGHVVEPIALPVTEQFAADFVQYWALLADLAVSTGKLILDRSFDAAATDGLTRGLRAHHRRNLHRTPAALRRLQRIPATYARLFAQSEVVVSPVLSHTTPPLGHIAPTVPFPELIDRLTRYVSYTPLNNIAGTPAVSLPMGRTPDGLPVGVQLSAAYGDERTLIELAYLLEAEQPFPRIQEQATNSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H081</accession>
    <name>A0A231H081_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sbcD_1</name>
        <name evidence="7" type="synonym">sbcD</name>
        <name evidence="10" type="ORF">B7C42_05474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42275">
        <property type="protein sequence ID" value="OXR42275"/>
        <property type="gene ID" value="B7C42_05474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="9">
        <location>
            <begin position="268"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR42275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="42006" checksum="E5ABE760126C0E06" modified="2017-10-25" version="1">MRMLHTSDWHIGRTFHGVDLLADQARALEAVAELVAAERVDVVVVPGDVYDRSIPSADAIAVCNKGFEAIRAAGATIVATSGNHDSPTRLGALGSFAAAGGLHLRTSVAEVDRPVVLTDEHGPVACYGIPYLEPEITRAELDVPQARSHAEILDAALARIRADRQRRGDPRTVVLAHAFVVGAEATGSERSIAVGGVETVPLSSFEGIDYVALGHLHSPQTLSESVRYSGSPLPYSFAERSHRKAVWIVDLDAAGLVSVQRHDLPVVRGLRQLTGVLDDLLSAADYADAEDDYVSAVLTDHARPVDALRRLRQRFPHAVHVEWSRPEGNAQLRYRERVHGRRDSEIAHSFLSDVRGEPTAGEMALIEQALSAARREPATEVVAAAAELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0B2</accession>
    <name>A0A231H0B2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">fumC</name>
        <name evidence="5" type="ORF">B7C42_05486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780586.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42287">
        <property type="protein sequence ID" value="OXR42287"/>
        <property type="gene ID" value="B7C42_05486"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="16"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="406"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="468" mass="50011" checksum="13276846BDEE84E2" modified="2017-10-25" version="1">MTDDQTQYRIEHDTMGEVRVPVNALWRAQTQRAVENFPISGRGLERAQIRALGLLKAACAAVNRDLGLLDGVKAEAIIAAANEIAEGRHDDQFPIDVFQTGSGTSSNMNANEVIASLAAARGVTVHPNDDVNMSQSSNDTFPTATHLAATEAVVKELLPALDHLRLRLLDKATEWRTVVKSGRTHLMDAVPVTLGQEFSGYTRQVEAGTERLVAALPRLGELPIGGTAVGTGLNAPAGFGAKVVAELRKTTGLDELAEARNHFEAQAARDGLVEISGSLRTIAISLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAVAWGGGNGAFELNVYIPMMARNVLESIRLLSNVSRLFADKCVAGLTADTERLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALRENKTIRETVVDRGLIGEKLSEEELDRRLDVLSMAKVEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0K1</accession>
    <name>A0A231H0K1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42415">
        <property type="protein sequence ID" value="OXR42415"/>
        <property type="gene ID" value="B7C42_05616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025506">
        <property type="entry name" value="DUF4393"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14337">
        <property type="entry name" value="Abi_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="33120" checksum="DBEFF82383F269F0" modified="2017-10-25" version="1">MAVSGSAPENGDGAEFSIEYAEVVAESGDAAAGTGATEIETVFPEPDARSTDLVARRSAELMLPEDARPGWAGPVRTTTGVVRVALSAVTEAAAWSLGTAVGVTATVVRGSMSGQPPRHVLSEAGEQVRDSLRRALGIDATPGGAPAPTAPSLRDRGAELLRRSADVHCEDSDHPAFARILAELAPDEARILRFLYLDGPQPALDIRTGRPLSSGTQRIEVGMSLIGETAALRFADRAITYLTNLRRLGLITVEGDQLDNPVRYQLLESQPEVRRLLKRGFGTKVAYRSIALTSFGTDFTCACLPVPPLGHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H130</accession>
    <name>A0A231H130_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42558">
        <property type="protein sequence ID" value="OXR42558"/>
        <property type="gene ID" value="B7C42_05335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="21084" checksum="D4AC8550EF111037" modified="2017-10-25" version="1">MHLIEVERKRALTDAPSLRDRLIALGYHENARVTETDVYYSRPDVDYMQTVECLRVRRRGDFCEITYKPPSDSGTHGASHIIAKHEINVALAGIADSEAARALLEAVGMRELAVVEKNRYVFRHPDRQDTVVALDSVTGAGEFVETEVCASDPHDAATHLEQVELELRIDTLPVVTLPYRDLVMMAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H132</accession>
    <name>A0A231H132_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactaldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aldA_2</name>
        <name evidence="3" type="ORF">B7C42_05308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.22" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42532">
        <property type="protein sequence ID" value="OXR42532"/>
        <property type="gene ID" value="B7C42_05308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008911">
        <property type="term" value="F:lactaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="36"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="463" mass="47935" checksum="9EB035999DB38B4C" modified="2017-10-25" version="1">MSAGDVCPRTPGYSEPMTEIDNATRIEADSVTGNLDLMTIVGAAHTAQSNWARTPAASRAEALRAGATALREHADELAATLEAETGRPADSGREGVLAGAGTLDQYAELGPVHRGHTLQGSWDATDFMIAQPRGVVVALTPWNDPVAIAAGLVGAALATGNAVVHKPSERCPQTGALFGRLLEQHCPDGVLQTVRGDGRVGAALAGLPGVDVVAHVGGTATGRTIAAAGARTGAKVLLENGGNDPLIIDADVDPVWAAEQAALGAFANAGQICVSVERIYVHREVADAFVSALCEQSQRWNLDPQPLVDERLRTQVHAQVRDAISAGAKAPVGGRIPEGPGTTYPATVLTDCRPGMRVIREETFGPIAPVQVVSDFATGLDAACRDDYGLAATVLTGSMDHMQQAWRTLPVGTVKINSVFGGAPGGAAQPRGTSGTGFGYGPELLDEMTTTKVVHMEPAPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H135</accession>
    <name>A0A231H135_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42559">
        <property type="protein sequence ID" value="OXR42559"/>
        <property type="gene ID" value="B7C42_05336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="89" mass="10175" checksum="ABEB78D893A1B31D" modified="2017-10-25" version="1">MDGRPAPVRRFLPELIRLIWDRTIAPGKVFDLTLPLGDAAKGYRAMDERRGDPVSRRTRGRRTISVPGRRYARAVRGRLCVSEGYITHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1C5</accession>
    <name>A0A231H1C5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative diguanylate cyclase YcdT</fullName>
            <ecNumber evidence="3">2.7.7.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycdT</name>
        <name evidence="3" type="ORF">B7C42_05441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042544.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42663">
        <property type="protein sequence ID" value="OXR42663"/>
        <property type="gene ID" value="B7C42_05441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="221"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="366" mass="39114" checksum="770EAE56FFF40E1D" modified="2017-10-25" version="1">MNGGKTLRAWWNDPVDYCWLIRSLTARSALGPLKVLVGVAGAMIAAMGAVITGSPVGPPGHPGIASTVGVSCGTLWALRWWLLRWPGRTESLLLIGGADVLFILEFLQVPDRLFAAMGTVLLVVTGSYLGFFHNARVLAAHSAWSLLAVIVMSVRIATGGGQLRLAVAVGLLLFVSVVSAVPALQILYWLLRTESMSDPLTELLNRRGLEIRLPLLVDQHPAISVMTFDLDKFKSVNDTWGHRVGDTVLVRTARRLHEAAGRTAVVARAGGEEFVVATPIAAGAAHAEAERLRRIVAEPSGTTVEVTASVGVAVYDAATCPRCPRPTPDRLLQSADAAMYRAKQAGGNLVVVEDLTPPPDHHRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1L1</accession>
    <name>A0A231H1L1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42697">
        <property type="protein sequence ID" value="OXR42697"/>
        <property type="gene ID" value="B7C42_05033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="2">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="200" mass="21817" checksum="195299F9BC5EC601" modified="2017-10-25" version="1">MTSDRDGYGSPVRKWSRKNSLSGLKLRSEMDPREADVLRSLVGAVTGLLTDRAQSSPEDDLAELTGLRTGNSIPPDDPRLARLLPDFHRKEPGSPDADRADLNSALRSLHEPEIIDAKVAAGTVVLETLPERGGKIVLTPEQADAWLNALNDVRLALGTALGIDADTPDQLDPDDPRAPHLDVYHWLTWMQDSLLHALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1P9</accession>
    <name>A0A231H1P9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase</fullName>
            <ecNumber evidence="4">1.14.99.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ncsB3_3</name>
        <name evidence="4" type="ORF">B7C42_05111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.49" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42773">
        <property type="protein sequence ID" value="OXR42773"/>
        <property type="gene ID" value="B7C42_05111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="410" mass="44724" checksum="51574566DF2832CB" modified="2017-10-25" version="1">MNASCPHAAPLVIDPMVGDLAGETARLRDAGQLTRIELLGVPAWTVTGHTLARQLLIDPRLVKDINSWSLWRDGVVTRQWPLIGMIDVGVSMFTVDGPEHRRLRIKTTQALTARRLTALRPFIESTVAALLDDLAAASGDGTADLKSVFAYPLPMRVISELMGVDHADHPMLLDWYKAFFSLLTPQDERLAVIERMGEYFTAMVRKKAATPADDLTSALILATDGGEPLSEAEVVGNLQALVAAGHETTVSLILTTVRALLTHPEQFALVRSGQIDWETAIEETLRWDGPVTHLLMRFATEDITVGDTVIERGEGVVMSYRAIGRDTTVHGADAGEFDITRPTAKRHISFGHGPHICPGAALARLEASIALPALFERFPQLSLAVPVEEIHNLPVLTQNDLAQFPVRLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Q2</accession>
    <name>A0A231H1Q2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42747">
        <property type="protein sequence ID" value="OXR42747"/>
        <property type="gene ID" value="B7C42_05084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="125" mass="13934" checksum="EF39B1D95EC5AA58" modified="2017-10-25" version="1">MDAVVTEVAVEGKRLIDEVWLGRISREQAVHRFVQVGDGLVEFDTAADIVDDGLAWLDSHASRLRLLAWCSWLELPVFGGLAVLGVLTEDYLSTGFSLILLAALQLVHRHIGPPRPPIRRRQRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1S9</accession>
    <name>A0A231H1S9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42798">
        <property type="protein sequence ID" value="OXR42798"/>
        <property type="gene ID" value="B7C42_05136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="15"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="162"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="297" mass="31678" checksum="1D9E7DDA456BD42D" modified="2017-10-25" version="1">MTESADAYLADEPDRPIVVGVDGSEISYQAVAWAAVDAVLHGRRLDIVTSATLPTGFGSEMWTGGADWVREDGERIVAEARRVAGLVQGPLEINAELVFDPIIPTLIARSERAYRLVVGSRGRGAVRRVLLGSVSSAVVQRAHCPVAVIPGNSATDMVTAAKPVVVGVDGTENSEPAIGVAFDEASRRKVPLIAVHTWSDISLPEVVVAGWDTLRESERAALSESLAGWREQYPDVDVRPVVWADRPARALLAESEHSQLVVIGSHGRGGFTGMLLGSTGHALLQSSECPVIVVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1V0</accession>
    <name>A0A231H1V0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42824">
        <property type="protein sequence ID" value="OXR42824"/>
        <property type="gene ID" value="B7C42_05162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013402">
        <property type="entry name" value="CHP02569"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02569">
        <property type="entry name" value="TIGR02569_actnb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="30213" checksum="31F406BFAF11C407" modified="2017-10-25" version="1">MRATFGLREVSPVALGDWDGGWRCGEVVLSPVADHARAAWSAKVRETLRVDGVRLARPVRATDGRYVVSGWRADTYMDGTPEPRHDEVVSVSLRLHYATARLERPRFLAQQPIAPWVDVDVFVAADRAAWETVPLRSLKAGGMLPVTTPDGRHSIDMLAQLATLRKPVQIPSQLVHGDLFGTVLFTNGQAPGLTDITPYWRPASWAAGVIVVDALSWGGADPGLLERWSDLPEWPQMLLRAVMFRLAVHALHPRSTPEAFPGLAHTADMIRLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H242</accession>
    <name>A0A231H242_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiocerol synthesis polyketide synthase type I PpsC</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ppsC_4</name>
        <name evidence="2" type="ORF">B7C42_04788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42902">
        <property type="protein sequence ID" value="OXR42902"/>
        <property type="gene ID" value="B7C42_04788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="254" mass="25022" checksum="2904F01D95D49EA5" modified="2017-10-25" version="1">MRELGADVTGLAVGDRMAAVALGGGGFAEIATARAELTVPVPDAVSLSSAAATPLGLATALLLLTDAGRFTAGDTVLVHSAAGGIGGAVAQLVPLLGGGRLLGAVSRARGSLPGFDSVLVRGDGLAGEIRSATDGRGVDLVLDPLGTEALDLEVTRPTGRIVLFGNAGSGAPAPLPPFGRLLGGNLTLTGFSHRGLVAGAPSKVAAATRQVLDYLAGGALSLPVTEMASLDEAITAHDLPASGHGTGKYVARIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2U3</accession>
    <name>A0A231H2U3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063009759.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43169">
        <property type="protein sequence ID" value="OXR43169"/>
        <property type="gene ID" value="B7C42_04591"/>
    </dbReference>
    <dbReference type="GeneID" id="66723525"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16631" checksum="4728EAC429A58F80" modified="2017-10-25" version="1">MTRSVPLAEGLFTWPSDDPALIGGKASDGSIVFPYREHRLVGGRREKLEPVELPRRGTLWTFTTQRFCPPIPPYAGDAEAFEPFAVGYVELPGALRVEARLTEPDPEKLRIGQPMELRIVPFGKNKEGAQTMMFAFAPVDEEEDSRGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2V7</accession>
    <name>A0A231H2V7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid metabolism regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fadR_8</name>
        <name evidence="5" type="ORF">B7C42_04596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43174">
        <property type="protein sequence ID" value="OXR43174"/>
        <property type="gene ID" value="B7C42_04596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="209" mass="22763" checksum="9454536D74A60C80" modified="2017-10-25" version="1">MSAPARMGRPVNADGEQTRLRIMTAAMDHIAEVGYAKATMKSIAEQAGLTSAAIYHYFPSKVELVTATLNVRIDEVMARLAHAVDFPGTLREHFVALLDEAIACVRDYPSVTRFDATVYLESARYPDLGAAVTRRQRAEEALYSWLVDEAVRAGEVAPGIDARSVVDMLTSLTWGLAHLSATATADRHRAAVRATEALLAGTLLIERNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H312</accession>
    <name>A0A231H312_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43198">
        <property type="protein sequence ID" value="OXR43198"/>
        <property type="gene ID" value="B7C42_04620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="277"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="37872" checksum="A9E85C1C315542AA" modified="2017-10-25" version="1">MAVEAGCAARRGGGQIARVTLVTRDFPLLEGGSGAVLLAGLGLDPDIEVTERIGGAPAALDAIATARPRTLVIAVDLEPAGAAAAVIGETGLTVRPVARLARSLPVRTRDAAGATRDYGDPRLLRERGILRSVRTAWPGEVSAVAGVDHKTATALSSATAPQLPTTGASAAVFALARMAETGTEGVLLGVEQATVSGLGVDGGTASVVRNELQARPVPHLVRAPGLDIPISLAAYERAFDAKLRWQASRNPATGALDFPPRLSIDTEGRLVEPAELVELPRTGAVYTQVTVHVPVPGLPSPYSLVIVELDGVAVRALAKTTAAESGSVGIGDRGRMVLRRVAVRSGVPDYGYAFIPDTAQHTQKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H344</accession>
    <name>A0A231H344_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43247">
        <property type="protein sequence ID" value="OXR43247"/>
        <property type="gene ID" value="B7C42_04669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="21456" checksum="C6D357DF84F85F88" modified="2017-10-25" version="1">MVSQLPETHERTTSDYAELAETVRRLQAAVCAADPPPDVIRRVVRELARTSAELEGHRVPEQQRPAHRRPTPAVTHPSLIPYVITEVDATRLVAATRFTDAHLGGNGAVHGGQIPLLFDDLLGIFVEMKAQPGSRTAYLKVDYRRITPVDRPLRVEASIDRVEGRKTFVNGRLLDGACVCAVAEALFVRLLPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3A0</accession>
    <name>A0A231H3A0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43335">
        <property type="protein sequence ID" value="OXR43335"/>
        <property type="gene ID" value="B7C42_04758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="134"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="223" mass="23572" checksum="3476DCBE6E32C4B5" modified="2017-10-25" version="1">MIDWIAPARRKLLSRLTPGDPSLTALPIDDPLNDSAIAVRRIIGALARTAPDDAALPAAAAELERIAEALESRTRPVRAQLSQMWQGEGIARHDPATGPENPIAPPLTMRDAGNGWAEGVVTLGLPYQGPPALVHGGVSALLLDGALAVANELSGSGGMTAQLEISYRRPTPLYVPLTVRARRLRRDGRKVYTMGEIVADGQVTVSAQGLFIVTDRPRAGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H417</accession>
    <name>A0A231H417_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rubredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rub</name>
        <name evidence="7" type="ORF">B7C42_04541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821270.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43673">
        <property type="protein sequence ID" value="OXR43673"/>
        <property type="gene ID" value="B7C42_04541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR43673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="54" mass="5658" checksum="4EB0E92D0AF3F5C1" modified="2017-10-25" version="1">MFCLVAVAGGTSSDPAEGDPDGVGAPGTAFEDIPEDWLCPVRGARRSDFIPYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4B0</accession>
    <name>A0A231H4B0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor BepR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bepR_2</name>
        <name evidence="5" type="ORF">B7C42_04414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43546">
        <property type="protein sequence ID" value="OXR43546"/>
        <property type="gene ID" value="B7C42_04414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="20196" checksum="79362D8DB1F79918" modified="2017-10-25" version="1">MAQQRRERADAARNRRAILDATRALLAEGGAEAVTMDRVAATAGVGKGTVFHRFGSRAGLLHAMVAEPAETLRAAITDGPPPLGPGAPAGERLLAFFDAMATMVADNVELMVAAYRSVPPHPRTSEFHATWAEHITKLLIEARPELDAEAVGHLLFGMLGSDYALAAVREGESERLRAAVRQVVLAVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4J4</accession>
    <name>A0A231H4J4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">deoC</name>
        <name evidence="4" type="ORF">B7C42_03983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43748">
        <property type="protein sequence ID" value="OXR43748"/>
        <property type="gene ID" value="B7C42_03983"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="224" mass="22588" checksum="0940872C90CECF38" modified="2017-10-25" version="1">MSDTAPTAYTRAQVAAMIDHTLLAPEATAADVANTIAEARALGVYAVCLSPSMLPVTAPGLAVATVAGFPSGKHHSLVKGAEARFAVEQGAAEVDMVIDVGAAIAGDYNAVLADIVTVREAVEDRALLKVIMESAALSDAAIIEVCRAAERAGADFVKTSTGFHPAGGAEVRAVRLMHETVGGRLGIKASGGIRTAAAAAELIAAGATRLGLSRSADVLAGFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Z5</accession>
    <name>A0A231H5Z5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="2">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ahpD_2</name>
        <name evidence="2" type="ORF">B7C42_03842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44281">
        <property type="protein sequence ID" value="OXR44281"/>
        <property type="gene ID" value="B7C42_03842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="19017" checksum="CAA199B9C07D0272" modified="2017-10-25" version="1">MFVHDNDHDSKDDVMEPRFTLTDNALGAKFAKRFGNTSMVILQSTLPKATQDLMMLRVSQINGCGWCTDVHSKDLAAAGEPAVRINLVAAWREASVYTDAERAALALAEEGTRLADAHQGVSDETWAQVRKHYDDDQIAALVGLVAQINAANRLGVIVRQQGGSYDPGMFAEITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H667</accession>
    <name>A0A231H667_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44196">
        <property type="protein sequence ID" value="OXR44196"/>
        <property type="gene ID" value="B7C42_03756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="389" mass="42681" checksum="420BD6B657F3F3F7" modified="2017-10-25" version="1">MRSITVAQRRARLARRHRLAFEARGTDPADIAESMVALHATDPATVYLSVCARTRGLAPADVERALYDDRSLLRLLAMRRTMFVAPVDLVPVLQAAVADALAVKQRRAYGKYLAQAVEGDIDAWLAEVADETHRELLARGSATGAQLSAAVPRLRTQVDTAPGKPYSKPTNITTWVLLILGCDGLIVRGRPNGSWTSSQYTWAPREAWLPDAAPVALDAARAELARRWLRTFGPAPVDDLVWWTGWTKTDVRKTLSSLELTEVDLGGRTGVLLSDDTDPEPESGPWAALLPALDPTPMGWQSRDWFLGPHTPALFDTNGNIGPSIWVDGRIVGGWAQRADGDIAWRLLEDVGADAKALIDAEVERTAAWYGDVRAIPRFRTPLERELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H670</accession>
    <name>A0A231H670_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44335">
        <property type="protein sequence ID" value="OXR44335"/>
        <property type="gene ID" value="B7C42_03896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="332" mass="35845" checksum="A477E48C8BCEF8EF" modified="2017-10-25" version="1">MKILVAGASGYLGSTVSRLLDADGHEVVALSRSGRTRYGTGIAGDVNSPGFGSTDEALDALTDVDAVVCGFGSVDMGSDPTGVVNLHLNGTRNVLDLAASIGSVRRVVYVSSILALGRATGPITNRDLSRGQTFRNWYEYAKYRGELIARRERRVPVTVLRLGTLLGPAPAELIPRRGGPVSVLPHLLSGLPVTLHDCGRYPVYAADVEVAARVVRDITVCDEHRSGCTYFDPERPTLADVLERLCRPWQVVPKIVDATGPAWTRRLLTRRFGLEEDVVDYARPLFDFDPGIFDTLPTPDIRSATDYIAETGVALRNSGLTSRSIDVLGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6D7</accession>
    <name>A0A231H6D7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44484">
        <property type="protein sequence ID" value="OXR44484"/>
        <property type="gene ID" value="B7C42_03273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="30049" checksum="987D20182585B3A7" modified="2017-10-25" version="1">MSGRQLAALAGWHESVVSKIETGDRSPTEAHLRAYCAHTGNEDQLPDLIATLRNVQAAYLEWRKVLGTGTKRRQQEAVKLAEESKLMRIFQPTIIPGILQTAEYAAAVLRRYIDFYQVPDDLDEGVSKRLERQQMLYRGDHRFHILVAEQALHTTVGTDAVVLGQLDRLLAVIGLPRVLLGIVPAQAEVPMQTTNFVIFDERLTLVEAVTAELTITQPREIAVYGRLFAELVEQSVTGDQAREIIRRAIESRTAETPRHLPRVPWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6Z9</accession>
    <name>A0A231H6Z9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tcrY_1</name>
        <name evidence="11" type="ORF">B7C42_03350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44560">
        <property type="protein sequence ID" value="OXR44560"/>
        <property type="gene ID" value="B7C42_03350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="310"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR44560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="532" mass="56940" checksum="335433372116F67F" modified="2017-10-25" version="1">MSDPRSVRERAVHDASDIEPVRPTGESEPGTDPGSGGVAGPAADAAGVAPPRRGIRRRISRRLAAVPLRVTLVLALVCLAGLGLLVSGVAVTSAMRNVLIDKVDRQLFDASHSWASPDATPPQHLPQPPGRERPPALFYVQVTGSTGNQRLLLSSGPTVPDTPSDLSKHPETVGSVGDPSEHWRAIKVVTPQGSSVVALRLTETENIIDRLIGLQVAVGLIVLAVLAVVAQFVIRRSLRPLGEVEKTAAAIASGDLHRRVPVQGTNTEVDRLSQSLNGMLSQIQSAFAATEASEESARRSEARMRRFVADASHELRTPLTTIKGFAELYRQGALADPALFMDRIERESKRMSLLVEDLLMLARLDAQRPVERRPVDLLALASDAVHNARAVDAAQRPEEPRRPVDLEIRPGTGTLEVRGDEARLRQVLNNLVNNALIHTPPEAAVTVALTPAPDEVVIEVSDTGPGLPAEDAERIFERFYRTDTSRSRDSGGTGLGLSIVQALVAAHGGTVSVRSAVGQGTTFAVRLPRSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H753</accession>
    <name>A0A231H753_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_8</name>
        <name evidence="3" type="ORF">B7C42_03416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44622">
        <property type="protein sequence ID" value="OXR44622"/>
        <property type="gene ID" value="B7C42_03416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="394"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="481" mass="50818" checksum="77674302CF158D7E" modified="2017-10-25" version="1">MHLSELPDLRSRHDPGGPCVADDQVELTNAEFADAVRRAATALAAHGVSSGDVVAVMLPNTVALVVSLFAAWRLGAAVTPINPSLVPAEAGYQVTDAGAEVLVTDRPTDIGVTVLTPAELTARPPADIAPETRDDALALLVYTSGTTGRPKGVMLDHANLNAMCAMAIGAFELTAGDHSLLVLPLFHVNGIVVSTLSPLLAGGRTTIAGRFSPTAFFDRLERSRATYFSAVPTIYTMLADLPPDVAPDTSSVRFAVCGAAPASAELLRKFENRYGIPIVEGYGLSEGTCASVVNPLRGRRKPGTVGLPLPGQTIRIADPDGNPVADGAAGEVLIQGPNVMRGYLNRPEDTARTLIDGWLHTGDIGRIDEDGYLVLVDRAKDMIIRGGENIYPKEIESVVYQLPEVAEAAVVGRASELYGEEPVLFLALNSGATLTAEQVLAHTRRNLSKYKLPVAITFLDGLPKNAVGKLDKPSLRRVTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7H5</accession>
    <name>A0A231H7H5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44831">
        <property type="protein sequence ID" value="OXR44831"/>
        <property type="gene ID" value="B7C42_02785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="185" mass="19797" checksum="63CE7A50E3D6ED87" modified="2017-10-25" version="1">MKGLNPAGEEAESIAALRDVAGALAVMSVARSKAVGLVRTEISGPDTARHDIEIQCLAHHLGFRWLCTLRPPEGARDPVGDILAIAAGMDASAVLVYDLTHVGDRPERVSADFDLATVAPPRLWLAGTTEPYAVEPPPLNDCTWEPTHLERDCARRLWEIHRDCFPGCLAGLAASAALSALDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7L5</accession>
    <name>A0A231H7L5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_8</name>
        <name evidence="5" type="ORF">B7C42_02825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783355.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44871">
        <property type="protein sequence ID" value="OXR44871"/>
        <property type="gene ID" value="B7C42_02825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="182" mass="20533" checksum="492D78EAF5FFFCE9" modified="2017-10-25" version="1">MAPPVRTPRRAWVDAGLSVLEHQGPDAVRVEALAAQLGVTRGGFYRQFRSRDELLEAMLDDWERRAVDDVREEVEREGGDPKRKIRRAGTLTFAQDLTPLDLAIRAWARRDPDVEARLRKVDNARMDYLRTLLRNSGVASEDVEAVALLSFSMVIANHLIKAEHPGQSRSEVLAHAARLLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7V0</accession>
    <name>A0A231H7V0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE</fullName>
            <ecNumber evidence="2">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiE_2</name>
        <name evidence="2" type="ORF">B7C42_02824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44870">
        <property type="protein sequence ID" value="OXR44870"/>
        <property type="gene ID" value="B7C42_02824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="29025" checksum="641836D7BEF0AB89" modified="2017-10-25" version="1">MSDEQGVPSFHIDQVDHPEQDLIVRILDSQAALPGVVRMREWARAALALRPGETALDLGSGTGTEVVELAAQVGESGRAIGVDPNPSMLTVARERAADVKAEFIEGSAYDLPLPDASVDAVRCERVYQHLDDPAKATAEIARVLRPGGRVVLIDSDWSTAIFHPGDPEVVAALQQRMETNSPNRNSGRHLRGRLVEAGLVIDDIGSEAVIWEPEAILPMFTAVTERGVADELITAEQRDRVLADVRRAAESGDYHFSVTMFAVVAHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8C1</accession>
    <name>A0A231H8C1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_03046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781005.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45089">
        <property type="protein sequence ID" value="OXR45089"/>
        <property type="gene ID" value="B7C42_03046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="220" mass="24228" checksum="AA095FD429F55647" modified="2017-10-25" version="1">MADSPHTPKTGSRPWRGREPADRIAARRERLLQAGYELMAGAGAAETSMRGVCRQAGLTERYFYESFANLDDLMTTVLENTVEQCRDRLLAALADAPEDRDLLFGHVVRAFTDFLTEDPRRGRILFVESIATPALTRRGSELVAVITGPIASVIAADDTDTPAPDETDATLNAMAIFGALAYCYRPYLIGDITIDRERFDNHAAAIIRQLSTVRSAPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8E8</accession>
    <name>A0A231H8E8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45108">
        <property type="protein sequence ID" value="OXR45108"/>
        <property type="gene ID" value="B7C42_03065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5154" checksum="A37C8A3FEA8C89F9" modified="2017-10-25" version="1">MSEQPNLFSHSPVPIETPAPAGGVAHRPLFRSASSSAGPEGGEAPADDVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8I4</accession>
    <name>A0A231H8I4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase fadE25</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_02379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776753.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45254">
        <property type="protein sequence ID" value="OXR45254"/>
        <property type="gene ID" value="B7C42_02379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="385" mass="41425" checksum="70E3DC0F04135AA2" modified="2017-10-25" version="1">MAGNPDFDLFKLDDIHDELRAAIRGLAEKEIAPHAKDVDGNARFPKEALDALNAAGFNAVHVPEAYGGQGADSVATCIVIEEVARVCGSSSLIPAVNKLGTMGLILQGSEELKQKVLPDLVEGKMASYCLSEREAGSDAASMRTRAKRDGDDWVINGSKCWITNGGQSTWYTVMAVTDPEKGANGISAFMVHKDDEGFVVGPLEHKLGIKGSPTAELYFENCRIPGDRIIGAEGTGFKTALQTLDHTRPTIGAQAVGLAQGALDAAIAYTKDRKQFGKAIADFQNTQFMLADMAMKVEAARLMVYTSAARAERGEKNLGFISAASKCFASDVAMEVTTNAVQLFGGAGYTTDFPVERMMRDAKITQIYEGTNQIQRLVMSRQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Y0</accession>
    <name>A0A231H8Y0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">birA_2</name>
        <name evidence="4" type="ORF">B7C42_02387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45262">
        <property type="protein sequence ID" value="OXR45262"/>
        <property type="gene ID" value="B7C42_02387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="11"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="260" mass="27308" checksum="DAE0A1A2EA8D4EA6" modified="2017-10-25" version="1">MDADILRHAVAEQPDLSFFSRIDVVESTGSTNADLIGEAGDPSSDRRVLIAEYQDSGRGRHERSWVSPPRAQIAMSILVRLGGIEPAVLGWLPLLTGVAVVDAVRETTGLDANLKWPNDVLIGGRKVAGILAEVASGAGAPAVVVGVGLNVSLTEDELPVPHAISLTLAGAENADRNALVLALLRAFSRHFTEWRTENWNVGALADAYRARCATLGADVRAELPGGEVLTGVATDIDGYGRLIIGGRSVSAGDVTHLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8Y1</accession>
    <name>A0A231H8Y1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase iron-sulfur subunit</fullName>
            <ecNumber evidence="8">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhB</name>
        <name evidence="8" type="ORF">B7C42_02434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036498394.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45309">
        <property type="protein sequence ID" value="OXR45309"/>
        <property type="gene ID" value="B7C42_02434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="28779" checksum="BA584F55018650E8" modified="2017-10-25" version="1">MTAVAEAPAGQKPAPVPDGSTMVTVKVARFNPEDDKGAHWDSFQVPVLPTDRFLNVLIYIKSYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVLMRDMLPKNGKELTVTVEPIRGLPVEKDLVVNMEPFFDAFRAVKPYLITSGNAPTRERIQSQTDRHRFDDTTKCILCACCTTSCPVYWSDGSYFGPAAIVNAHRFIFDSRDEGARERLDILNDVEGVWRCRTTFNCTDACPRGIEVTKAIQEVKRALLFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H915</accession>
    <name>A0A231H915_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45321">
        <property type="protein sequence ID" value="OXR45321"/>
        <property type="gene ID" value="B7C42_02446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="406" mass="42581" checksum="250EA61DE06747ED" modified="2017-10-25" version="1">MGIEIPDYLKPVASLVACDWPKADETALLRMADHWEHMGDTLSQIRAEGDAVTTAILARIDGRTHESIQQFWRTAGDDLDGLVTFCKAIAIACRVMSVLILAVKLYIIAMLAELAINLAIAAAAAVETLGASMAEAAAAEVATRVVILQALKQLLTRIIKETAIEGFKGFMKGAGKELAWEAGENALGLRDGFSLDDIGKAGLHNGISSAASGALGGALRKVGVDEHNKSPDGRNPHTHEPESPGAPKTEEREKFEGKVGDFGEKVAGEVVEGPQDDKKRLKTDATQLAKHWFGHDSGSSTPTSAAQLPSSTPNLLSDSATDLYSWYPDANPDGGGLDHGPSGATVPGSGDDPSVLYPDSRPDGGNAESPQPAVSSAVASGGSGFSLDLDGDTFYREENGGRLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H944</accession>
    <name>A0A231H944_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45322">
        <property type="protein sequence ID" value="OXR45322"/>
        <property type="gene ID" value="B7C42_02447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="119" mass="12759" checksum="7FF1A18FF8EF94F5" modified="2017-10-25" version="1">MTSGNEFRIELDEFRRHAPRLGQLGKQLEQDLKNLTVDLGEVTGTWGDDIFGSAFAQNYLPKAEQALQDIAKAALMFAHLEESSGAAADTLEAADEGLAGVLNTVREAIEKNGINGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9L0</accession>
    <name>A0A231H9L0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal large subunit pseudouridine synthase A</fullName>
            <ecNumber evidence="2">5.4.99.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rluA_1</name>
        <name evidence="2" type="ORF">B7C42_02663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.28" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45538">
        <property type="protein sequence ID" value="OXR45538"/>
        <property type="gene ID" value="B7C42_02663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="99"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="35744" checksum="B72083305D809D68" modified="2017-10-25" version="1">MRRRQQPPLPKRHGLDPARLRLPEDGTWATIRDHLVHRLPRVPAARIDEMLAGGDIVDLDGPIEPDAPYVPGGAVWFHRDLPDETPVPFEVTVVHRDDHLLVVDKPHFLSTIPRGQHILETALVRLRRDLDLPDLIPAHRLDRTTAGLILFVVDPARRGAYQTLFHKRRVHKQYEAIAPYDPRLTLPRTVRSRIIKERTILRAFEVEGEPNAETLIELIDHRDGLGRYRLSPHTGRTHQLRLHMNGLGVPILGDDFYPELTDRPVDDFTRPLQLLAARLAFTDPISGAERVFETTRTLQAWTDYAGWNGEPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Q6</accession>
    <name>A0A231H9Q6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacetyl reductase [(S)-acetoin forming]</fullName>
            <ecNumber evidence="2">1.1.1.304</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">budC_1</name>
        <name evidence="2" type="ORF">B7C42_01880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.304" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783970.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45588">
        <property type="protein sequence ID" value="OXR45588"/>
        <property type="gene ID" value="B7C42_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052588">
        <property type="term" value="F:diacetyl reductase ((S)-acetoin forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="275" mass="28075" checksum="132F4D382A7CADAE" modified="2017-10-25" version="1">MTWPSGEAAFVTGAASGIGLGIARALVAAGAAVALADVDGTRLAAVVDEITAQGGRAVAIELDVSAEDAWAAAADRAEAALGPTSILVNNAGVISNAPIAETTPEAWRRNFRVNVEGQFLGTSTFLSRFIERGGRAHILNTASMGGLMPIPGVGAYCASKFASVGLSLVLREELRGTDIGVSVLTPGTVATGMTAAEGAGGANPDRVGEQVVEALQAGRFLIPTHGDFEPILANIHREIEQAFADTDDRHGPDPSAQMILAGVDPLNELLADGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9U4</accession>
    <name>A0A231H9U4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase TesA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mbtB_1</name>
        <name evidence="6" type="ORF">B7C42_02641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45516">
        <property type="protein sequence ID" value="OXR45516"/>
        <property type="gene ID" value="B7C42_02641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Thioesterase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="27196" checksum="DCB05855ABA0B1D4" modified="2017-10-25" version="1">MAAAPGWIRQFHAPRGASAPLIICPHAGGGASTYRPFSKQLREHFDVGVLQYPGRQDRAREAALRTLPEIAEGAFDEFALSPWNRDEPITVLGHSMGSIVAFEFVRIAESEGVPVRLLAVSGAVPPGRVAEMPGHPTEDEQLLDHMAGLEGTGSDLLGNRELMRMALPALKADYAAFDRYSCPADVRVQAPVQAMGGSDDDYVTMGDLYGWQQHTESHLRVSMFDGGHFYLHDHVEGIAELLAAEMETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9X4</accession>
    <name>A0A231H9X4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45640">
        <property type="protein sequence ID" value="OXR45640"/>
        <property type="gene ID" value="B7C42_01932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="14123" checksum="AE462F6F4F336253" modified="2017-10-25" version="1">MIESLILRVWRSKDSTPLPALLAEEATFSSPVADYHGRARAAHLLATIATVLDSVHQTRQWTDGQQRIFAFTARFAGQELEGVLREELSETGSLTHVTLFLRPYRVLRAAIAEMARRLEASPPPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA02</accession>
    <name>A0A231HA02_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45670">
        <property type="protein sequence ID" value="OXR45670"/>
        <property type="gene ID" value="B7C42_01962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="170" mass="19390" checksum="D62A407FFB3C7E24" modified="2017-10-25" version="1">MFGRTFTYRLERRGPAAPEAMFDLIRDAEGWPRWAGPLITYATWRDGKTGVGDDIVGRVRLMGTPRFQTPEQITVDDRPHVHAYRILTRWPVRDYHARVEFTPHDDGTTTVRWSGEYIERIPGTGWLWKRFLLRFLGDLADNLLIAAAEPSSDSEQRDAGPGPGRTADHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA24</accession>
    <name>A0A231HA24_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caffeyl-CoA reductase-Etf complex subunit CarC</fullName>
            <ecNumber evidence="3">1.3.1.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">carC_2</name>
        <name evidence="3" type="ORF">B7C42_01981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.108" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782607.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45689">
        <property type="protein sequence ID" value="OXR45689"/>
        <property type="gene ID" value="B7C42_01981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="170"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="301" mass="31953" checksum="EF19942A79F598DF" modified="2017-10-25" version="1">MDVRLTSEQRQLRDAAAKLADDLGPGSVAELADRERITRLDKTVELTGWRALRSDGASGVEVALVAEEFARGLVDVAFLGPVLADDLRGHPAGDEGRWTLGVRGRAVDAAGCDRAVVLADGQVLAGRLGSAAPLADPTRTAADLDGRLEYIGELSADQASQWFALALVGTTADVLGAARGAQRLAVDYAKVRAQYGKTIGSYQAVAHLLAESQALIEGSVSVLRYAAWGVDELAPDEAVRAARIAKIYCARAARTVCETAIQVHGGIGNTWECLAHIYLRRVLVSTELFPVRLEEIARGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAA2</accession>
    <name>A0A231HAA2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inner membrane protein YgaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygaP</name>
        <name evidence="2" type="ORF">B7C42_02047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778179.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45755">
        <property type="protein sequence ID" value="OXR45755"/>
        <property type="gene ID" value="B7C42_02047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="80" mass="8393" checksum="E0C38231243BDA07" modified="2017-10-25" version="1">MPNLPRHQGWSIARVVPLLAGTLVLISVVAAAAWSGWWLVLTGFVGANLLLYGVAGWCPATLLLRRLGLPATAGCAVSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAB0</accession>
    <name>A0A231HAB0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Neopentalenolactone D synthase</fullName>
            <ecNumber evidence="1">1.14.13.171</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ptlE</name>
        <name evidence="1" type="ORF">B7C42_02080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.171" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45788">
        <property type="protein sequence ID" value="OXR45788"/>
        <property type="gene ID" value="B7C42_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="608" mass="68443" checksum="26EC3EE65FAD8A33" modified="2017-10-25" version="1">MKPCAPTRTPEVDREALRQKYLAERDKRLRPEGQQQYLEAAGEFADFYEADPHLPVVPRAPIDADIEVVILGGGFAGLITAHRLQQAGVTDFRIVELGGDFGGVWYWNRYPGIQVDSDAYCYLPLLEETGFIPKEKFSHGDECYEHAQRIGKHFGFYDKAIFHTLVRALEWDEQIARWRIATNRGDEIRARFLIMCQGPYNRPKLPGIPGITEFEGHTFHTARWDYDYTGGDLHGGLDRLGDKKIAVIGTGASGVQVIPHLARGAKHVTVFQRTPSYIFERDNHPTDPEWVASLQPGWRTERQRNFHNAAFAFYSPGEPDLICDGWTEVARNLAAKLNETDGWAALADPATFLELKEIEDYRAMERLRRRVEEIVEDPETAEKLKPYYRNMCKRPVFNDDYLPTFNRPNVTLVDVSDTKGVERITRTGVVAHGVEYEVDCIVFASGFEITTALDRQFDIAPFAGRGGKSLYEHWGKGFRTLHGIMAHGFPNHFATGFIQGGVTAATTLMYEQQADHIAYIIAQAQSRGATRVEPTAAAEEAWVQTIRANTVDNSTFVTECTPGYYNSEGEPNGRSFLGDPFWGGFYVLEDLLQAWRAAGDLDGLTLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAL4</accession>
    <name>A0A231HAL4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45900">
        <property type="protein sequence ID" value="OXR45900"/>
        <property type="gene ID" value="B7C42_02192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019919">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03617">
        <property type="entry name" value="F420_MSMEG_2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="35830" checksum="E6D1343E06539028" modified="2017-10-25" version="1">MKVHLQVEGSPLRARDSARAIAALGADGIFSFEGTHDVFVPLVLAAAETDLHLMTNVAIAGPRSPLHLAHTAYDLQALSGGRFRLGLGSQTRVHIEKRYGSRWERPAARTGESVAAVKAILAAWEGHAPLDFRGEFFTHTLMPPTFDPGPNPFGPPPVLMGALGPVMTRTAAAVADGLLVMPFNSATHFTGRTVPALRRGLADSGRTLDEFEVVAQAMVALGRTAGELAGAVDAVARLIAFYASTPAYRPVLDAEGWGEVQPELNALSKQGRYAEMPALITEPMVRTIALVGSPADCAAQAHARFGDYARDICCYFPGYDPASDAVAEFVARLQSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAN2</accession>
    <name>A0A231HAN2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <ecNumber evidence="2">6.3.5.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gatA_3</name>
        <name evidence="2" type="ORF">B7C42_02307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR46014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46014">
        <property type="protein sequence ID" value="OXR46014"/>
        <property type="gene ID" value="B7C42_02307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="482" mass="51421" checksum="CFE2F112266122FC" modified="2017-10-25" version="1">MDWNFQSAEEIAAAMRAGAVTSVELTDAAIARIERDDKAINAICVPDFDNARAAARAADRARARGEDRPLLGIPVTVKESYDIAGLPTTWGMPQHANYVPAEDAVQVSRLKAAGAVILGKTNVPVMLRDIQSFNEIYGTTNNPWDHDRTSGGSSGGSAAALACGFGALSIGSDLAGSLRTPAHFCGIYAHKPTLGLAPTRGMVAPPAPALPVDLDLAVAGPMARTARDLTLLLEVMAGPDPLTHGLAYDVALPPARHDRLAEFRVLVLEEHPLIPTGSAVRAGVNRVAEALVDEGARVERHSPLLPDPAEAATLYMQLMLSNAAAGLPLEVYRELQTRAAALSADDRSLDAARLRGMVLSHRDWVGANNGRELHRHGWRQLFAEFDAVVCPITPTPAYPHNHDGELEDRHVDIDGVEYPYFDQLVWAGVATMPGLPATAIPAGRSPEGLPVGVQLIGPMFEDRTPLRLAELLEEKIGGFQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAR9</accession>
    <name>A0A231HAR9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036502267.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45948">
        <property type="protein sequence ID" value="OXR45948"/>
        <property type="gene ID" value="B7C42_02241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="14843" checksum="589474185C262F89" modified="2017-10-25" version="1">MAAIVWLVAGILLAAAEMLTGDFTLLMLGGAALITAGVAGIAQTSVVIDAVVFAISAIGLLFVVRPMLLRRFATPPPTPTNVDALPGKTAKVLEAVNENSGQVKIGGEVWSARPFDPADEYAEGETVYVMKIDGAHAVVWKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB16</accession>
    <name>A0A231HB16_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46124">
        <property type="protein sequence ID" value="OXR46124"/>
        <property type="gene ID" value="B7C42_01089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014512">
        <property type="entry name" value="O_gly_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021505">
        <property type="entry name" value="O_gly_hdrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="391" mass="42573" checksum="030654938C5E7796" modified="2017-10-25" version="1">MQPRPHLRRGRARVDSAAEPGAEIWAQRADAAESAIVSRHLRRLWLLPGAELGVVGWPATRGERLFLNWNYWWQAHLIDCAVDAANREPTPVRTARIAAVAHALRLRNITGWTNNYYDDMAWLAIALERAERTQGRTEVRGGLIALEQQLMAGWQPEIGAVPWRKGADYFNAPANGPAAIALARLGHHERAAQIADWIDATLRDPETGLILDGIHLPSGRIERPTFSYCQGVVLGLETELAVRTGDARHLARVQLLLRAIEDHMTERNVVTGGGGGDGGLFNGILARYLALVAIMLPGDEMPQRSARRSAAAIVKASARAAWDRRLEVEGDPLFGHDWNEPARLPGGTAGAGRPTSGGSVTSSRTPERDLSVQLSGWMLMEAAQVVTAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB29</accession>
    <name>A0A231HB29_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_01002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46039">
        <property type="protein sequence ID" value="OXR46039"/>
        <property type="gene ID" value="B7C42_01002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR46039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18813" checksum="2EBE43C1D7CF97F7" modified="2017-10-25" version="1">MTRERLVRIGVLIWLAVVYTALWGNASVANLLAGLVVGILIMVLLPLPRVPVNGGLRVLPLLELIMLTAYYAIESSLQIAWFAVRPAGAPVSGVLRVRLAIDSDLVLVLCADVLNLIPGTMVLELDRVAGVAWVHVLDVGSDDAVEKFYYITRRLEGLLIRAFEGRKQEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBD8</accession>
    <name>A0A231HBD8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46254">
        <property type="protein sequence ID" value="OXR46254"/>
        <property type="gene ID" value="B7C42_01220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="103" mass="10600" checksum="D538EEC5F5A1077C" modified="2017-10-25" version="1">MKITPESLREAAIGLGKLGEAVSDTNIFPLLNAERGVTALQGSPIAAALSGADAASSQAKRTLSSRHAALADLLYSTAATFQGQDEDLANQLKDFGDLNAKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBG4</accession>
    <name>A0A231HBG4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0301 protein B7C42_01250</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_01250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46284">
        <property type="protein sequence ID" value="OXR46284"/>
        <property type="gene ID" value="B7C42_01250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="208" mass="22960" checksum="7DDEC681834B0E5C" modified="2017-10-25" version="1">MMTTVARAEEHGDRPRRESRYEEQAVRPGTLLVSATELVEPTFRRTVIYIVEHNDAGSLGVVLNRPSETAVQDVLPRWADLAAGPRTLYVGGPVKRDSALCLTTVRVGASIDGIRGLRRVDGRVALLDLDSDPDSIAPLVEGIRIFAGYAGWTFGQLEGELERGDWIVLSALPSDPLARRTDLWAHVLRRQPLPLSLLATHPIELERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBS9</accession>
    <name>A0A231HBS9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-ethylmaleimide reductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nemA</name>
        <name evidence="2" type="ORF">B7C42_01297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46331">
        <property type="protein sequence ID" value="OXR46331"/>
        <property type="gene ID" value="B7C42_01297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="13"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="362" mass="38769" checksum="32311176E86ABFA2" modified="2017-10-25" version="1">MLLLTDYHASHLHLPNRVVMAPMTRLRSHPDGSPTDDVATYYAQRADAGLIVTEGIWPHSTGQSEAWVPGLATEAHIAGWRRVTEAVHGAGGRIFAQLMHGGRWGHPLARIDGTLPAGPSAVPAADPVHLIDGGKAAAPRPRAMTRAEIARAVEHYAAATANALAAGFDGVEIHGANSYLVHQFLADNTNLRTDEYGGTIANRMRFALEVTDAVAAVAGPHRVGIRLSPGNPQFGMHEADPAPLYRALVGELAGRDLAYLHLTDNDDYPALADLRPRWSGTLIANIGENRAPTAPAAAERVLADGRADLVSFGRAFIANPDLVSRIRHDRALAPVREDGLYGRGPAGYTDYPAWIDHDERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC80</accession>
    <name>A0A231HC80_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_062994910.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46491">
        <property type="protein sequence ID" value="OXR46491"/>
        <property type="gene ID" value="B7C42_01461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="246"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="327" mass="34893" checksum="6978009E2AD519D6" modified="2017-10-25" version="1">MTTAQTNHTPTADQALRALGEVRAEIGKAVVGNDHAVLYLVLALLCRGHVLLEGVPGVAKTLLVRSLAAALELEHTRVQFTPDLMPGDVTGSQIYDPHSAEFTFRRGPVFTNLLLADEINRTPPKTQSALLESMEERQVSVAGVPQPLPDPFVVIATQNPIEQEGTYPLPEAQLDRFLFKVDIQLPGRDDEFRILQRHAAGFDPRDLGAAGVRPVAGAAHIAAARAAVAQVTVNPEVLAYIVDLCRATRTSPAVQHGASPRGATAVLASARALAWLNGRAFVTPDDVKTVAVTVLRHRLQLRPEAELDGVTGDGVMSSLLAAVPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCD0</accession>
    <name>A0A231HCD0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46317">
        <property type="protein sequence ID" value="OXR46317"/>
        <property type="gene ID" value="B7C42_01283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027595">
        <property type="entry name" value="CHP04338"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04338">
        <property type="entry name" value="HEXXH_Rv0185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="176" mass="19464" checksum="7024DA9165C58DC1" modified="2017-10-25" version="1">MVRESAVTQRDSQRSRVYDAEGLVRRMFDRAEEFGARTVDLHGSQLTLPIERKFASVESVQRYVDRVLALNWIRAQWVRADTPLAVRARAGTAAAHYETGRSVLAVPLHTGGTAWALRELVILHELAHHLEPPGADLAPHGPEFCTRYLELVDGVIGPEAALLLRATLHDCGARVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCG1</accession>
    <name>A0A231HCG1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative decaprenylphosphoryl-5-phosphoribose phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46570">
        <property type="protein sequence ID" value="OXR46570"/>
        <property type="gene ID" value="B7C42_01541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="79"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="20253" checksum="F8A1973C9B5BA3FE" modified="2017-10-25" version="1">MTAPASSDPAGAPHLQVVADPEVSKPAEVKILNAVQGAIGTPPVIKAARGMSHFGEHALGWMAIGAAGALVDKSRRRQWAGVAVGAFGAHAASVVIKRIVRRPRPHDPSVQVNVSTPSKLSFPSSHATSTTAAAVLLGKLTGLPLPAVLVPPMLLSRVVLGVHYPSDVLAGSALGAASAAAVLAAEKRFASDRTGKNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCL6</accession>
    <name>A0A231HCL6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46703">
        <property type="protein sequence ID" value="OXR46703"/>
        <property type="gene ID" value="B7C42_01678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="278" mass="30148" checksum="B871AA433DB034A9" modified="2017-10-25" version="1">MAELALTAERREELAGLLGDEQRLRAEYSKVADYLDTAPMLPGTGNDPADAAFDLRLVHYMTGGPSISANPYWDIVGPSVSEHQGRRVVDGGRPRGSARLGFAQTILQAAYAYAIPSPETVAWMHQFCNGRSVVELGAGRGYWAAQLASAGLDVAAYDWQPPDQSDNPSFTQAEGQADVWLSVGDLGRFAARSVGSADEVLFLCWPPGWGNPMASDALAAFDANGGRRLVYIGEPKGGKTGDEAFFDALDSRWKIESEDSDFVSWWNLADRAQGWVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCP0</accession>
    <name>A0A231HCP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46674">
        <property type="protein sequence ID" value="OXR46674"/>
        <property type="gene ID" value="B7C42_01649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15027" checksum="110A7C96865DECE7" modified="2017-10-25" version="1">MSEPISTPTAGVVPPALAAVPGTVPSPSAPPPPPDPVELGDTIRNMVRFREQGLEGLGAAAGIKFQPGGPGTEVFTIPHPLLMSDEQNEELAKPQGFLGIAKLILNSEADPHVYERFRAAGGQAGDVMIAWRTLSNGLDVPKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCW0</accession>
    <name>A0A231HCW0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46761">
        <property type="protein sequence ID" value="OXR46761"/>
        <property type="gene ID" value="B7C42_01739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371124" evidence="2">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="206" mass="20831" checksum="26243D7678115FE8" modified="2017-10-25" version="1">MKFGTFAATSILAVATVGITAGTVNASPPAAPPAAAKEITTSGTDRGVTYHAVLSDFSRVLTTVVEHGRFEVDKDATAVALKSDNGTDLVTVPLTYRMAGSTVHVAQHISDDGHKVVLEPKATATEIGEMQPINSMARLTNEINQNVVGLVAGGVLGGLIGAVLGMGFFSIITGPIGMVVGAIAGGYAMGGQPFLDAVNAVVSGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD25</accession>
    <name>A0A231HD25_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46668">
        <property type="protein sequence ID" value="OXR46668"/>
        <property type="gene ID" value="B7C42_01643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="15882" checksum="09C46A43E5ECA3EA" modified="2017-10-25" version="1">MRYRVLANLVIANDSAGRAHHVYKDGIITDLAAKQRPHLLDMGMIEEIPDATPPGVVGPDDEDDQGDAPAIVAQPVTVPQTTDNAGSTPVVSQQVGDNPESNSGQSEVPARPPQIAKKEVWLDWAVKAQKVTPEQAESMTLEQLKALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDJ8</accession>
    <name>A0A231HDJ8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_00006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46892">
        <property type="protein sequence ID" value="OXR46892"/>
        <property type="gene ID" value="B7C42_00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="67"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="264" mass="29978" checksum="BEBD41E565EB6C33" modified="2017-10-25" version="1">MGYESDRIAGTEVGTVCHPRVATASLVDVVEARTAPRSNRRPDPALELQDDPQELMPRRRPTQERSKRKFDALLQSSRELLVEVGFESFTCEEVAARAEVPIGTLYQFFANKYVIVCELNRQDLVAVSQELADFHGEIPSMDWLRHMNKLVDHLAELWMTDPSRREVWLAMQSTPSTRATGAIHEKEFAEAVQQMLRPLMPRTPRGRRSMMAQVLVHVVYSMLNFSVQDGLSHEAAVAELKRLMVAYLLIAEKESRTGQRDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDL4</accession>
    <name>A0A231HDL4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46855">
        <property type="protein sequence ID" value="OXR46855"/>
        <property type="gene ID" value="B7C42_01833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="416" mass="45236" checksum="BA76449FAD24AA0E" modified="2017-10-25" version="1">MSSVSASRFAALSREQLAALVPELLLCGHLIDRSGMAHSIGAFGRDGMAEVAIEEWQLASPIYTRRMRAALDIPGDGVVTIFKGLQLDIGAPPQFMDFRFRVDDDHNGEFWLDHCGALADVEPMGEDYVVAMCHTIEDPTFDATALATNPHAQVRPIHRPPRQPADRVPVCAWTVRIDPANEPPAVPRNAARMAEFAAVDIELAPIEAGGPGRSDYRGPLLSDIDFASFSHSALVRMADEVCLQQHLLNLGFLIAVGERADAQTTAAIARKQFTGIAGLTSERLRAVLGLGTGFEDLAQVLRLHPAWNPLPYVDMQVDAYHDSAILRIARDSPGVRDGGWPAAVDAEHLEPLAAMVRGVNPRFDVHAREGDERELVVEITAAATPFREAPEVAITRFSTGADFHFSPRQSLPLTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDS1</accession>
    <name>A0A231HDS1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051042139.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47034">
        <property type="protein sequence ID" value="OXR47034"/>
        <property type="gene ID" value="B7C42_00153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="89"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="400" mass="45549" checksum="D8C76775651A400D" modified="2017-10-25" version="1">MADPDGAGAALCERYAVADVDSHIIEPADLWTSRISKKWGDLVPHVRFHERRQEDYWYIGDKKLYGVGAFAQAKWPEFPPSHPKKLSEAFPAALDAEARLAYMDEVGIYYQVMYPNILGFHSHVFLNSMPHELATECVRAYNDWLAEWCSADSRRLVPMMMLPFWDIDEAVTEMKRAYELGHKGVLFAARYDKVGLPRLVDDYWEPLLGQAQDMGLSMNFHVGFLNSPDDLKGAVDQSQKLDFTQESALVLLGNARNIAEVVVSGVCHRYPELNFVSVENGAGWLPFLGESMDWQWLNVGAHHEYPDRLLPSEYMRRQIYGMYWFENRSLRPVIGELADNLMFETDFPHATSLSPGPASESPSPRDIIDRSLTGIPDETVAKVLQHTATRLYHLDPPQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDT0</accession>
    <name>A0A231HDT0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778120.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47019">
        <property type="protein sequence ID" value="OXR47019"/>
        <property type="gene ID" value="B7C42_00137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="110" mass="12082" checksum="A7CB366F994F9E5F" modified="2017-10-25" version="1">MPAYISSPELTFGFLFALEDPERIAEVVRNLMERRTVSVFRLAHVSGAAGPPERYVVNWAAIPQISITTAAPDADAMQAERIMLVNAFLGEGGEVSLYSADSNRPDDKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDW5</accession>
    <name>A0A231HDW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase YngG</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yngG_1</name>
        <name evidence="4" type="ORF">B7C42_00074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46958">
        <property type="protein sequence ID" value="OXR46958"/>
        <property type="gene ID" value="B7C42_00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="33795" checksum="CAF50EE7A86536F2" modified="2017-10-25" version="1">MVMLTPSRFTAAGLPESVTIYEVGPRDGLQNEKGVIPTAAKIEFIGRLGAAGLRTIEAAGFVHPVRVPQLADAEAVIDGLDLEAGVRYPALVPTVSGLTRALGRGIRDIAVFGSATETFSQRNLGRSVDESLEMFAPVVAKAREAGASVRGYVSMCCGDPWEGEVPVAAVVDVAVRMMELGCTQLALGDTIGAGTPGHVTVLIEALVEAGIDIDSIAVHFHDTYGQALANVLAALRSGVRTIDSSAGGLGGCPFAESSAGNLATEDLVWMLHGLGIDTGVDLHRLVATSVWMAERLGRPSVSRTVQALAAEVQTPISESASVAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE67</accession>
    <name>A0A231HE67_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777033.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47149">
        <property type="protein sequence ID" value="OXR47149"/>
        <property type="gene ID" value="B7C42_00271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="15849" checksum="B5E974B5C47E80D3" modified="2017-10-25" version="1">MTHVKTAVPATIAFRLGTLGAIVTDRFAVAIEELDLKPKHVGVLVALDHGVAASQQDLAARLGVAPSLVVALADHLERLGAVRRDRDPDDRRRQILTLTDHGRELLAATEERARRLDREFTGSLTAAQRTALQSALAVLAADAGLPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFA2</accession>
    <name>A0A231HFA2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47663">
        <property type="protein sequence ID" value="OXR47663"/>
        <property type="gene ID" value="B7C42_00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="114" mass="12200" checksum="D5D8670ABE854FD1" modified="2017-10-25" version="1">MSDSNKTVESRPVATVQEVLGALHDPVRLEMVRRLSNAGGPVRCGMLYDTINKSTATHHLKILREAGVTERIVADGQTYARLRSEEVEHALPGLLAAVVGAANRADDSGAAPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFU1</accession>
    <name>A0A231HFU1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma-F factor RsbW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsbW_1</name>
        <name evidence="1" type="ORF">B7C42_00879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47754">
        <property type="protein sequence ID" value="OXR47754"/>
        <property type="gene ID" value="B7C42_00879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="15757" checksum="C3FBAAD72F353278" modified="2017-10-25" version="1">MSLSEWISPSTDPAPAGSVVGVRVLAQARQLLMLRALAETVALMAEFALDEVTDIRVALDEIATALIERAVDGSSIECDFGYDGDRMSVAVTAVAVTPEALHRDGLGWHVLTSITDSLEATTAPFDSAVAGYPVTVEFRRSRRHGITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSJ8</accession>
    <name>A0A231GSJ8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000156">
        <property type="protein sequence ID" value="OXR39610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39610">
        <property type="protein sequence ID" value="OXR39610"/>
        <property type="gene ID" value="B7C42_08322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="61" mass="6675" checksum="8D8A6779C303C425" modified="2017-10-25" version="1">MSTSSIGDSIETSNTGSQGDAEKLFGTIDSEVLRRWLADDDELAVLDIRPALLLHDFRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSL5</accession>
    <name>A0A231GSL5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000157">
        <property type="protein sequence ID" value="OXR39609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39609">
        <property type="protein sequence ID" value="OXR39609"/>
        <property type="gene ID" value="B7C42_08323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010148">
        <property type="entry name" value="CRISPR-assoc_prot_CT1975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09344">
        <property type="entry name" value="Cas_CT1975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="8389" checksum="5E6AEF98AA493EF4" modified="2017-10-25" version="1">MNLVTAFEEPVNAVGAARSVAAAKALVTRYSAIESSFGDGATRNFVVATGEGADTLSAIAEPVSFAEAVEGVVDTVRAALGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSP0</accession>
    <name>A0A231GSP0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000418">
        <property type="protein sequence ID" value="OXR39565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39565">
        <property type="protein sequence ID" value="OXR39565"/>
        <property type="gene ID" value="B7C42_08367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012940676" evidence="1">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="7716" checksum="62936020A208A5A7" modified="2017-10-25" version="1">MLATQSISVRIAAATAVLATALLTGAGAAAAAEPDRQAEPTSVAPRGPQHLLHQFVTGIIGATGSQCSFDTRPDCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSQ4</accession>
    <name>A0A231GSQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000143">
        <property type="protein sequence ID" value="OXR39612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39612">
        <property type="protein sequence ID" value="OXR39612"/>
        <property type="gene ID" value="B7C42_08320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="45" mass="5258" checksum="B579CA832666EC60" modified="2017-10-25" version="1">MRARVATVAEYPALRREFVTMTADYEFYRRQAGGRTIPLVVLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSQ7</accession>
    <name>A0A231GSQ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000096">
        <property type="protein sequence ID" value="OXR39660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39660">
        <property type="protein sequence ID" value="OXR39660"/>
        <property type="gene ID" value="B7C42_08265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019276">
        <property type="entry name" value="DUF2303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10065">
        <property type="entry name" value="DUF2303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="197" mass="22076" checksum="C35520549B14243C" modified="2017-10-25" version="1">MIFADETQQRLTAVIDYTGWREHRIILQMMLSDQFARWKKGNGDYVAQTTFAEFIQDSAADIVSPTAADMLELAQSFQATKSVDFTSSNRISNGQVQLSYRETIDAQAGNAGQLEVPEQFTLHISIWRGGAVVEVKAALRYRIEHQQLRIGYKILHLDDLMRAAFEHVTDEIASKLDSGHGHELVFGPAPAVIEPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GT59</accession>
    <name>A0A231GT59_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000061">
        <property type="protein sequence ID" value="OXR39810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782192.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39810">
        <property type="protein sequence ID" value="OXR39810"/>
        <property type="gene ID" value="B7C42_08122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="14639" checksum="2C3E36DB70FD4B40" modified="2017-10-25" version="1">MAAGRTNLRDFENTGVEDRLLAGLAAHGVPEPMRNQVRSHLDEARDNCASTGQQAHWIQDRWAGRREKVALDRNPGPPAYDSPERLALLEHNWRQAGLTDDEIRQCRTAEKGRAKPPSAPANPIARNRRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTC5</accession>
    <name>A0A231GTC5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000060">
        <property type="protein sequence ID" value="OXR39828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39828">
        <property type="protein sequence ID" value="OXR39828"/>
        <property type="gene ID" value="B7C42_08116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="6864" checksum="BB3170579CD78EBF" modified="2017-10-25" version="1">MDAFVAAEDIEGDSAVTVRVVGLSVSGAFLRELGDGVGFGARGGRVVHACLASRVSGVTILMPENWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTD3</accession>
    <name>A0A231GTD3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator GltC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gltC_9</name>
        <name evidence="3" type="ORF">B7C42_08191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000075">
        <property type="protein sequence ID" value="OXR39741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39741">
        <property type="protein sequence ID" value="OXR39741"/>
        <property type="gene ID" value="B7C42_08191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="300" mass="33228" checksum="27B89140133D9B86" modified="2017-10-25" version="1">MERHEIEVFLTLAEQLHFRRTGEHLGLAHGRVSQIVAKLERRIGAPLFERTSRSVALTPIGEQLRDQLGPAYRAVQDAIADAIAAGKGIRGALRVGFSSPWCNEIVLAAAEIFRARYPECVVRIQEIQLHDPFGPLRAGELDLQLSEFPVIEPDLRTGAVIFTEQRALLVPSGHRLAQQDSVSMEDMADAPLLVVDGDIPQHWMDAIFPARTPAGLPITHVAAAVYWQEILTMVAAGRGVSTVSLRARHFFQRPGLAYVPVRDGPPIRYGLTWRRNCETARIRAFADIVVGLAPEFAEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTL0</accession>
    <name>A0A231GTL0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000049">
        <property type="protein sequence ID" value="OXR39967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782956.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39967">
        <property type="protein sequence ID" value="OXR39967"/>
        <property type="gene ID" value="B7C42_07974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011237333" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="77" mass="7612" checksum="0C8F537C5530AA2A" modified="2017-10-25" version="1">MKRLAVLAVTVAALGIAPAGIAAAGTGIPLEYSNTDQITANESVVLHTGSTVIDLLAYIGAGCIGSWSPAPPAYCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTN2</accession>
    <name>A0A231GTN2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE12</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_07959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39980">
        <property type="protein sequence ID" value="OXR39980"/>
        <property type="gene ID" value="B7C42_07959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR39980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="383" mass="41003" checksum="FF5917AB7305DA60" modified="2017-10-25" version="1">MDFAESDEQQELRRAIGAITDKYGPAYYAERAVAHEPTTELWQDLAAHGFIGINLPERYGGGGAGMTELAMVCEETAAHGCPQLLLLVSSAISGELLTKYGTDAQQREWLPRMASGTKVVFAITEPDAGSNSHRISTTARRSGSDYLLTGTKYYISGVDEAAALIVVARTGRDESTGAARMSLFLVPTDAPGLIKHRLPVGISVPEKQFTLHFDNVRLPAASLIGIEGEGFRHVFDGLNPERITGAAVCVGIGRFAIERGAAYARTRSVWGAPIGRYQGIAHPLAKAKIEVDLAAMMTAKAAWLYEKGLPAGEAANIAKYAAAEAAVAAVDQTIQLHGGNGISAEYGLLPQWGLARLLQIAPVSREMILNYVAQHSLRLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU47</accession>
    <name>A0A231GU47_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40098">
        <property type="protein sequence ID" value="OXR40098"/>
        <property type="gene ID" value="B7C42_07853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="172" mass="18645" checksum="67D059E4C43043B5" modified="2017-10-25" version="1">MRGRPPGRIHALIAVREAQAEAALGDRVAFGRAIATAWREMDHAAQFEAIEDCPQWLRFMNHAEIGGHEARGYGDVGDLPRSLELYTIAADQQAGTRNAINLRAWIATTRAQMGDVAGALESGTPVITDLSTVASTRTLRVLEPIRRAADNIAAGDTFRHQFDALTQKAITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU82</accession>
    <name>A0A231GU82_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40184">
        <property type="protein sequence ID" value="OXR40184"/>
        <property type="gene ID" value="B7C42_07766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="144" mass="15856" checksum="C7149EECCF24EAE2" modified="2017-10-25" version="1">MIPPLTPPQGPLEQLVRGPLAAPPEQAPIADDEILCGVCTLGESGRVLDRYIFKTLDWRPGTRLQIEPTDNLLLVSASCEGTVRITADGYFRVPFRQRRRVGLLTGDRVLLTSRRDDSRLLLHPPAAVATLLAARVTLLDRVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU94</accession>
    <name>A0A231GU94_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40197">
        <property type="protein sequence ID" value="OXR40197"/>
        <property type="gene ID" value="B7C42_07711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="52" mass="5883" checksum="26FD4EE8F76BA3C6" modified="2017-10-25" version="1">MTAKQKAPQVNPIVQAAADRARKSKRRKVKNLPANWERPGQPGLFKESEVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUA0</accession>
    <name>A0A231GUA0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argS</name>
        <name evidence="13" type="ORF">B7C42_07718</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000037">
        <property type="protein sequence ID" value="OXR40203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40203">
        <property type="protein sequence ID" value="OXR40203"/>
        <property type="gene ID" value="B7C42_07718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="429"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR40203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="552" mass="58997" checksum="DE1378FF07F1F75A" modified="2017-10-25" version="1">MTPADLAELLRATAAKVLVERGSDPAVLPDEVKVERPRNPEHGDYATNVAMQVGKKAGMNPRELAGLLADALAATDGIESADVAGPGFLNIRLAAAAQGAIVEQIRAAGAAYGTAQALTGTKINLEFVSANPTGPVHLGGTRWASVGDALGRILAAQGADVTREYYFNDHGAQIDRFAESLVAAATGAPTPENGYAGAYISEIAGQITAAHPDAVSLPENERHELFRREGVELMFAHIKQTLHDFGTDFDVYFNESSLFASGAVEKALDQLKASGNLYEKDGAWWIASTEYGDDKDRVVIKSDGKSAYIGGDIAYFQNKRSRGFDLCIYMLGADHHGYIGRLKAAAAAFGDDPNTVEVLIGQMVNLVRDGVAVRMSKRAGTVVTLDDLVEAIGVDAARYVLVRSSVNSSIDIDLDLWTKQSSENPVYYVQYAHARTCAVARNATDFGFAGVTADLGLLVADEEGELIRTLGEFPAVVASAASLREPHRVARYLEELAGAYHRFQTNKTLRILPQNDDPVLPVNAARLQLVDATRQVLSNGLALLGVSAPERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUB6</accession>
    <name>A0A231GUB6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000038">
        <property type="protein sequence ID" value="OXR40168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40168">
        <property type="protein sequence ID" value="OXR40168"/>
        <property type="gene ID" value="B7C42_07750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="659" mass="69089" checksum="7483AF1A644B084D" modified="2017-10-25" version="1">MSRISKSLSADVGRRLTALRRSRIASALLILILIVPTLLSAVYMWILWDPTNYLDRIPVAVANDDAGSSAGGSPHNFGEEILDNLTSGKQLQFHRVTSHEAVEGLRQSRYSFSVIIPSAFTEQIESVTDAKPVQARIMVYYNDFNGTLGSSVADSVLAQAQQQITASIGRQYADQVLVGLNSLGAGLGDASRGSGQLAAGAGELADGSAQLATGLDQAASGSAELATGARQLSSGAGELATGATQLLTGTDELGSGANRIRDGIDQVVTPILDLLAPGDQLATDLGPLLDRLAATGDPAASGSAGRLKALLDQLRRTDAEGFTGQLAQLRDGTRELARQLTDPHADYRAGVLALTSGSGQLRDGAAQLDTGAGQLSTGLQQLAAGGRQVRDGAHQLDDGAGQLDSGLRSGAAQAPQISDVDASSHMFSEPFTLDVHNQEPGQLVVDGDKSHKKLARGSGPLIVLLATFLGTIVAWMYADPNRGEIHGRRVRPAARAVLRRMWIGVAAGVAAAGVASAYGAYLGWSPHNWPAMLAVVAATGAAAGIIAQFFVTAFGRVAGSMAAVAFFMFQLFAFGGVFPAGTTPPAFRPFEDIAPMTFARRMILRCDIGLYDRMFWISLVILVVMTVSAIAAAITARWLRQWADISERPHDDRPVTAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUH7</accession>
    <name>A0A231GUH7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40284">
        <property type="protein sequence ID" value="OXR40284"/>
        <property type="gene ID" value="B7C42_07622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046229">
        <property type="entry name" value="TnpC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19776">
        <property type="entry name" value="DUF6262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="14176" checksum="A110D4239A3E1646" modified="2017-10-25" version="1">MPPADNTRFLLEATQRRSVEARTRAEAAIATAARSRGRVTVAAIAKTAKVSRSWIYTQSDLVEAISVLQQRNPASGHPARASASTESLQTRLAAATERNKQLRRQLAQLTEQLETAYGEIRALRNAQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUI0</accession>
    <name>A0A231GUI0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KAP NTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40280">
        <property type="protein sequence ID" value="OXR40280"/>
        <property type="gene ID" value="B7C42_07618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KAP NTPase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="738" mass="82379" checksum="0B8DD3279E008B09" modified="2017-10-25" version="1">MSDVLEDAHGINTDTEITKMANDGLERVPFARRVTDRIRAAGAEQSVVFGLAGPWGSGKSSALNMIAEILNTEHADQWSVAWFTPWSASDHDALTAEFYRAIASAMPDNKQGNKARKLLRSAAPMLSAVVKAAAASVTDKYLGDDAAAKITTAATDAAADTLGELPEPEEDPFSQRFLKLSEAIAAAGRNVLVIVDDVDRLHTDELLTVMKAVRLLGRFDRVHYLLSYDEQTVIDVLVETDLARNNRRRAARYLEKIVQYPFMLPPIQQLHLAEAFRTQIDAVANRYQILSTGEPDADPDYRGVTEAVFALLPSYTLTLRSIGRLCSQVDIMLALVGAAEVDLFDMLLLTYLRLEYRQLYLALPGWRQQLVSTRRRDHSDDRETLEQWTSRVAEAAEVDPTSQDGSLVYKIMASLFPALPKPRRFFVRSRQGKCRLGDDSYFDRYFAHRLPLGDIADEEVRTHLSILARTGTVDANSVFSLCMPDRDRRQLLLGKTLQNLDVIAEVPDPGSCAQAASALTGLLPNESRDYYFTRWGEVIFVFLGHSVSLAEPDHARQLVADHRARHGLDATVDVLFRHIEFPTIDEPKMLHATSVVRQEVLDVCLYDLTHDILAAGSRYSQGVLSFIHCFDADLWARLRTEVARIREEDGTPVYEFAARFVNVMEFSGSGGRSDNEKVVHFEPTTFAELIPAEEWNLDDLPTSTSEDVFEPGTLDHRRAVAIDRLRRALLKMQGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUJ7</accession>
    <name>A0A231GUJ7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000035">
        <property type="protein sequence ID" value="OXR40297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40297">
        <property type="protein sequence ID" value="OXR40297"/>
        <property type="gene ID" value="B7C42_07635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="27178" checksum="40EC693A95CDEC94" modified="2017-10-25" version="1">MCLLTYYPAGAAIDKGALRFGADANPDGHGFAIVAGGRIITGHGMNADTVIGTFARTRADHPDGPALFHSRYATRGAIDLSNCHPFRLGGDAQTVLAHNGTLPKRVHPRAYDRRSDTRIAAEDYLPTQPFGPIDTVAGARGLSGWLGTSKLVILTVDPAYAHTAYLFGERAGQWVGGIWYSNRSFLPPEQRWPARRRTVCGYCLDRDLERTSRYCRTCGWCFGCHHALFSCTCESAPTSRTPTRFPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUU9</accession>
    <name>A0A231GUU9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_07586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40325">
        <property type="protein sequence ID" value="OXR40325"/>
        <property type="gene ID" value="B7C42_07586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="398" mass="38875" checksum="B8DF1E7EADA3738C" modified="2017-10-25" version="1">MLNVLVAAQILSGAGLAAGITVGALLAQDMLGSTGLAGLPSALFTAGSALAAIAVGRLSQACGRRPGLAAGYLTGALGSLGVIAAAVLDNPVVLFVALFVYGAGTATNLQARYAGADLAEPAHRGRAVSTVLVATTLGGVVGPNLAAPTGDLADTLGIPYLAGPFLLAALAYSLAALVLGLWLRPDPLLLARELGAAHPVDTAQAANTVSARGIERGIATGGFVMAVTQLVMVAIMTMTPVHMLAHGHGTAAAGVVIAVHVGAMYLPSPVTGWLVDRYGRLPVAAASGITLLGAGLLAALAPGDSIVLLALALALLGLGWNLGLVAGTAIITDTVPLATRAKTQGTVDVSIAIAGATGGMGSGLMVAATSYPALALAGGVLALAVVPVAAFSGNRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVB0</accession>
    <name>A0A231GVB0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40563">
        <property type="protein sequence ID" value="OXR40563"/>
        <property type="gene ID" value="B7C42_07372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="136" mass="14463" checksum="DC8861F07311DC27" modified="2017-10-25" version="1">MSTVDQLERSAPTTSDTGAAPRVRRGKAGHSVMSRRSYRSVLSTRSHRSILSFRSERSILSIGSAYSVLSIGSVGSVLSVGSVGSFFSLGSAFSGLSRWSLLSWMGVRDAPEARPTLTVVADEPDLVADPTCHCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVN4</accession>
    <name>A0A231GVN4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator HmrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hmrR_3</name>
        <name evidence="2" type="ORF">B7C42_07248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40690">
        <property type="protein sequence ID" value="OXR40690"/>
        <property type="gene ID" value="B7C42_07248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="12476" checksum="0A84BF30442C9209" modified="2017-10-25" version="1">MKIGELAERTGVSVRALRYYEERGVLKPERTATGYRVFGEPDIRTVAHIRTLLAAGLHMDLIGEILSCLSGDSLLLDGCRERLEVERRRITGDIDRLVHTRSLLDDLLATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVU2</accession>
    <name>A0A231GVU2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40753">
        <property type="protein sequence ID" value="OXR40753"/>
        <property type="gene ID" value="B7C42_07177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046179">
        <property type="entry name" value="DUF6188"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19686">
        <property type="entry name" value="DUF6188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="176" mass="20130" checksum="7102489B883AABC0" modified="2017-10-25" version="1">MKADEISRAIIEHEDRWLFKPLRGRTVIRIEWKSDHLELVLDDNYFHVFVGYDAELSARSLAKDSPDRHRIDHWNRAEVEEFLGSKIVSAVFFKSGAVRLGLKNGWILFVEANPQGFSAEVQFGDRAVWNTAGITDHSIFEIQPLDAWTGQPVTPTHWPGRPDHLKDNPGSDDIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW18</accession>
    <name>A0A231GW18_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/glucose cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT</name>
        <name evidence="8" type="ORF">B7C42_07104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000026">
        <property type="protein sequence ID" value="OXR40820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40820">
        <property type="protein sequence ID" value="OXR40820"/>
        <property type="gene ID" value="B7C42_07104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR40820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="573" mass="61312" checksum="1A220117466D8278" modified="2017-10-25" version="1">MQPLAQLPHRFDAAAAVLGADQLRLDAAPVDYALVAVYFVFVLGIGLMARARVSSSIDFFLSGRSLPAWVTGLAFISANLGAVEIMGMSANGAEYGMPTMHYFWIGAVPAMLFLGVVMMPFYYGSKVRSVPEFMRRRFGTGAHLVNAISFALAQVLIAGVNLYLLGSIVNVLLGWPLWVSVIVAALIVLSYITLGGLSAAIYNEVLQFFVIVAALLPLTLVGLHRIGGVSGLKDQVTARPDGSEQWHSWPGHELSGFSNNILSVTGIVLGLGFVLSFGYWTTNFVEVQRALATHSISAARRTPIIGAYPKMFIPFIVVIPGMVAALLIPQIAELKNTGQGDATYNQALLYLMKEVLPNGLLGVGLAGLLAAFMAGMAANISAFNTVFSYDLWQQYAVKDKPDGYYLTVGRLATIGATAIAIGTAFIAGSFSNMMDYLQTLFSFFNAPLFATFILGMFWKRMTPTAGWVGLVCGTLSAVVIFILNKAEVFHLSGQGSSFVAAGVAFVVDMALSIAVSMWTTPKPDAELVGLVYSETPKAQLTDPDAATLPWYQRPVLLAGIALVIVIALNIFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF8</accession>
    <name>A0A231GWF8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein Stp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">stp_15</name>
        <name evidence="7" type="ORF">B7C42_06902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40936">
        <property type="protein sequence ID" value="OXR40936"/>
        <property type="gene ID" value="B7C42_06902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR40936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="472" mass="47402" checksum="69AF5CC4592CB6B1" modified="2017-10-25" version="1">MTSTPQVRNPAIILTVMCAGMFLVLLDVTIVNVALPAIGRGLRTDVASLQWVVDGYVIAVAGLLLAAGTVGDRIGHRRMLLAGFAVFGPTSLACALAPAIGVLIAARVVQGVGGALLLPATMAVIVDVFPDRVRQAKALGTWAAVSSLALPAGPLLGGILVDRFGWRPVFWIAVPLTIAATVAARAVVPAAPARHGGRLDVPGLAGFVLGLSALVFAIISAGHHAGTAVVGIAAVVAVGALAGAYGSGRRSTHPFLPVDLLRHKEFLAPNVVALMMNLIFNGILFLGMLYLQDTLGRSPVAAGVSVLPLALPLVLLAPVSGRLTARHGPRPAIAIGCALAACGSAMLLTLDGGGGSGGLLLSFTVLGCGSGLITTSVVAATVRATPADRSGLATGVSNTARQVGTACGVAIFGAVAGSPTGAGFVDAVHTLAIGSALAWVVALLITVFAIEAGGSRRAEADRNSRPTEPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWK6</accession>
    <name>A0A231GWK6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron-dependent repressor IdeR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ideR_2</name>
        <name evidence="9" type="ORF">B7C42_06959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036503122.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40993">
        <property type="protein sequence ID" value="OXR40993"/>
        <property type="gene ID" value="B7C42_06959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040767">
        <property type="entry name" value="DtxR_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18357">
        <property type="entry name" value="DtxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR40993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="25196" checksum="11C8D48FDA13E294" modified="2017-10-25" version="1">MKDLVDTTEMYLRTIYDLEEEGVVPLRARIAERLEQSGPTVSQTVARMERDGLLMVAGDRHLELTDKGRAMAVAVMRKHRLAERLLVDVIGLDWQNVHAEACRWEHVMSEEVELRLLEVLNHPTTSPYGNPIPGLDELGVNSINSGEETLVRLSDLPPGQVSAVVVRRLSEHIQADPDVIGQLREAGVVPDARVTVETKPGVVIISVPGHVGFELSDEMAHAVQVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXE1</accession>
    <name>A0A231GXE1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41269">
        <property type="protein sequence ID" value="OXR41269"/>
        <property type="gene ID" value="B7C42_06667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="337" mass="34943" checksum="7258E41BF4090FD2" modified="2017-10-25" version="1">MTIRGPLIKLLVFVVVTTLAGFLVASTVGNIRFTPVTSYSAVFTDASGLKVGDDVKVAGIPVGKVHSVELTGPREALVKFDVDSQRPLTTATKLQIRYKNLISDRYLELTDSSPSAPALAAGAVIPASRTGAGLQMDQLVNGFRPLLQGLDPDAANRLTASLVEVINGRSDKIADIVRQVATLSGTLADKDRAIGAIITNLGAVMNTADQRGGDLSAAVTNLQKLVSGLNEDQATVTGAVDQLDGATSTLSSVLAEARAPLAADITQLGSTAANLNAETDSLNALLGGLPHAYQKISRASSYGNFVNFFVCGLAIRYPGPQGGADTPMVVAPADRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXI9</accession>
    <name>A0A231GXI9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoglycoside phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41316">
        <property type="protein sequence ID" value="OXR41316"/>
        <property type="gene ID" value="B7C42_06714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="30"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="346" mass="37641" checksum="9F980F52A6B51539" modified="2017-10-25" version="1">MAWDWDRETRNALAEFLTSRGIVSGPITTQAIGDGHSNLTFLVSDDTTSVVVRRPPPPPIPPGANDMLREATLLHALSATEVPVPEVLAVAQEGEVLDVPLYVMSFAPGPVVTIRTPPPLDTPEHRRAVGYSMIDTLADLHGVDWRAVGLDRMGRPEGFNARHLQRMRRLVADDEGNPPAEFADVDAWLQANIPPESGATLIHCDFRIGNVVLAPTTPGRVAAVLDWELATIGDPLLDVGYLLATVPEPGRPMNPTAQLSAAMLEPGYPSKDQLAQRYSARTGRDLDTLAWYTTLALWKLAVLYEYSRRRVLDGIGDPYYSDPALVRSFLDDARRAAGLAGVSAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXS9</accession>
    <name>A0A231GXS9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41388">
        <property type="protein sequence ID" value="OXR41388"/>
        <property type="gene ID" value="B7C42_06531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="185"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="34276" checksum="25BCE38323A0ED48" modified="2017-10-25" version="1">MSGVSAGARRLPAPSLRPYLGRYDGYLLHGFDPGVHVGMPSTTITVILTIDEPIDVPVSSHPDQAGGRWDALAGGLTLRPTLIAHNGYQHGIQLAVTPLGARALFGIPAGELGEWIVDLSDLLGSDAERVRERIAATTDWRARFAVLDEILCARVATLDPRRLEMDANLRRAWRLLTDPAGAPAVARVAHDIGWSRRHLAARFTAEFGITPKEAARLTRFEVSHRLLRRPEVSIAEVAAATGYYDQAHMAREWRESAGCPPSVWRAREVFPFVQDDGVPSEKGWEHDRNNPYRNDRNRDDVGSAVADVHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYF2</accession>
    <name>A0A231GYF2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_06278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41637">
        <property type="protein sequence ID" value="OXR41637"/>
        <property type="gene ID" value="B7C42_06278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR41637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="255" mass="25658" checksum="EAFF2BCCD5C203A7" modified="2017-10-25" version="1">MDVADWAVLLPAATVAGWVDAVVGGGGLIILPTLLLVAPTLAPQTALGTNKIAAFAGTSAAALTFARRVPMNRPLMLSGAVIAACAAAAGSAAVALIDRRYFIPIVMAVLIGVAIVVATRPSIGVTMATHPPTRRRTILVVGLSAGLIGGYDGLVGPGTGTFLIISFATLLGTEFVRAAAMAKVINCGSNLGALILLAATGHIIWSVGLGMAVANIAGSVVGSRMALARGAGFVRAVLLIVVTAMVIRLGWQQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ27</accession>
    <name>A0A231GZ27_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalase</fullName>
            <ecNumber evidence="3">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">katA_3</name>
        <name evidence="3" type="ORF">B7C42_06192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41850">
        <property type="protein sequence ID" value="OXR41850"/>
        <property type="gene ID" value="B7C42_06192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="80" mass="8539" checksum="B1EAF6EBC207E60D" modified="2017-10-25" version="1">MHDNTDPLTAAAGAPVTDNQNSLSAGPRGPLQLQDLWLLEKLAHFDREVIPEHRMHAKGSGAFVPVSSFTPTSTCARTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ88</accession>
    <name>A0A231GZ88_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41917">
        <property type="protein sequence ID" value="OXR41917"/>
        <property type="gene ID" value="B7C42_05901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="143" mass="15778" checksum="19205E668A02E45A" modified="2017-10-25" version="1">MPKPFSEAERQEFLAGKHIGVLSVAATDGRPPAAAPIWYDYTPGGNIRINTGAARRKARLVREAGVVTLTVQREELPYQYVIVEGTVVDAETPSPRDARVSIASRYLGPEEGRAFADRMDGNDSVLFTIRPDRWISQDYSGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZZ6</accession>
    <name>A0A231GZZ6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Periplasmic [NiFeSe] hydrogenase large subunit</fullName>
            <ecNumber evidence="1">1.12.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.12.99.6" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783729.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42169">
        <property type="protein sequence ID" value="OXR42169"/>
        <property type="gene ID" value="B7C42_05768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033748">
        <property type="term" value="F:hydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="598" mass="67715" checksum="E26A43BE162285B6" modified="2017-10-25" version="1">MTQIIPEASHKKIEPDSLVEMAWDPITRIVGSLGIYTKIDFENREVVECHSTSSIFRGYSIFMRGKDPRDAHFITSRICGICGDNHATCSCYCQNMAYGVKPPHLGEWIVNLGEAAEYMFDHNIFQENLVGVDFCEKMVAETNPSVLDAARKAEAPHAAMHGYRTIGDIMEALNPFTGEFYREALQVSRYTREMFCLMEGRHVHPSTLYPGGVGTVATVQLMTDYMSRLMRYVEFMKKVVPMHDDLFDFFYTAVPGYERVGLRRTLLGCWGSFQDPEVCNFEYKDMEDWGRRMFVTPGVVVDGKLVTTSLLDINLGIRILLGSSYYDDWTDQEMFVKTDPLGNPVDRRHPWNQHTNPKPQKRDLDDKYSWVMSPRWFDGKDHLALDTGGGPLARLWSTALAGLVDIGYIRSTGHSVQINLPKTALKGPVELEWKIPEYGSNTIERDRARTYFQAYAAACALHFAEKALTEIRAGRTKTWEHFDVPDEGIGCGFTEAVRGVLSHHMVIRDGKIANYHPYPPTPWNANPRDSFGTPGPYEDAVQGQPIFEENDREHFKGIDIMRTVRSFDPCLPCGVHMYLGKGTTLDLVHSPAQISTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H020</accession>
    <name>A0A231H020_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42208">
        <property type="protein sequence ID" value="OXR42208"/>
        <property type="gene ID" value="B7C42_05807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="85" mass="9398" checksum="B6841A443EAC18A5" modified="2017-10-25" version="1">MDARRVRRWSVVLQPGEALDYVAADWADTLVVVTRGELELECRSGRRARFAAGAVLAPAAIPVRRLLNPGPEPLMLSAVARRPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H026</accession>
    <name>A0A231H026_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">18 kDa heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778524.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42204">
        <property type="protein sequence ID" value="OXR42204"/>
        <property type="gene ID" value="B7C42_05803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="15881" checksum="55D960EF16887F14" modified="2017-10-25" version="1">MLMRTDPFRDLDRSTQQVFGTQARPVAMPMDAWREGDEFVVEFDLPGIDPDSLDVDIERNVVTVRASRPGIDSGRSMIAAERVRGVFRRQVMLGDSLDTDHIRADYRDGVLRLRIPVADKAKPRKISVDRVDNDRQAITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H048</accession>
    <name>A0A231H048_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RCS-specific HTH-type transcriptional activator RclR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rclR_4</name>
        <name evidence="5" type="ORF">B7C42_05710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42111">
        <property type="protein sequence ID" value="OXR42111"/>
        <property type="gene ID" value="B7C42_05710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="295" mass="31897" checksum="7F2D829A8E0A40E5" modified="2017-10-25" version="1">MLTTAVLEAPWRIRFADQAPLTMVTVLRGEGTLLLPDGLERRITVGDTAIVRGPETFVLVDGGDTAARPHQEYEVACFAPDAKCDPELDGVRWDADPAGETALIVGAYRASGRRHERLLRAVPPVLVVNDDVEVCAWMESMAADAARRPAGAQAMMDRLLDWALVCTLRDWFDGLEADAPGWYRGPADPVVGPALEAMHGRPAAGWTVASLAARAGVSRALFARRFTEVMGQSPLAYLTECRMDEAEELLADRSLTVAQVAKAVGYADAFGFSAAFKRRRGIRPSDFRATADIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H051</accession>
    <name>A0A231H051_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiolase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42234">
        <property type="protein sequence ID" value="OXR42234"/>
        <property type="gene ID" value="B7C42_05833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="399" mass="41978" checksum="2FA661112912B3A1" modified="2017-10-25" version="1">MPDNDRDIAVLGAGMHQWGKWGRNFVEYGLVAARAALADAGVDHRDVGYIAGADTIRNGYPGFVSGATFAQALGWSGARISSSYAACASGAQAIANARAQILAGLTDVTLVVGADAAPKGFFQPVGGERRDDPDWLRFHLLGATNPIYFALYARRRMALHGATLDDFAAVKVKNAKHGLNNPYARYRKEVAAEEVAASAIVSDPLRLLDICATSDGGAALVLTSMDYARRHGIADPVRIRALSTVTPTFPKTVLDLPDFATDSAVAFDAPSRSFRSAIADAAYEEAGLGPADLSFAEVYDLSTALELDWYEDIGLCEIGGAEELLRSGATTLGGRVPVNPSGGLACFGEAIPAQAIAQICELTWQLRGQADGRQVENAHAGIAVNQGLFGHGSAIIATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0K4</accession>
    <name>A0A231H0K4_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42348">
        <property type="protein sequence ID" value="OXR42348"/>
        <property type="gene ID" value="B7C42_05547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556643" description="DUF305 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="69"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="213" mass="22641" checksum="D35970CAA93DFA0D" modified="2017-10-25" version="1">MFTSRIRMLSTAALAAAALIVAGCGSDDSGSSNTAAPASSSHSPMADMPGMNHTGAPSTATRTDYNDADVSFLTMMYPHHAQAVEMAKLVPARSQNQELITLAANVEKAQAPEMEQFAALLHSFGKPAPQATMNHPMDGVMTPEQMTQLRNASGADFDRMWLQMMIAHHQGAVDMANTEIADGTNADAKALAHNILTAQQAEIQQMRGMLGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0Q9</accession>
    <name>A0A231H0Q9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ispE</name>
        <name evidence="11" type="ORF">B7C42_05619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42418">
        <property type="protein sequence ID" value="OXR42418"/>
        <property type="gene ID" value="B7C42_05619"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="84"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="199"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR42418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="298" mass="30625" checksum="1BDE36A71DC2CCC0" modified="2017-10-25" version="1">MRAPSKVNLHLGVDDLRSDGYHELTTVFQALSLSDDVRIAPAGSLAVSVHGEGAAQVPTDRTNLVWQAAVRLGHLAGRAPLVEIEIEKGIPVAGGMAGGSADAAATLVGLNELWSLEMSRDELADVAAELGSDVPFALHGGTALGRGRGEKLLPVLSRNTFHWVLALAKEGLSTPKVFGELDRLRENGDPPRLGDPQELLQALASGDATQLAPLLGNDLQAAALSLNPALRRTLRAGVEAGALAGIVSGSGPTCAFLCGSEDDAVEVSAELSGAGVCRSVRTATGPVPGARVLADGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H102</accession>
    <name>A0A231H102_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypoxic response protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrp1</name>
        <name evidence="3" type="ORF">B7C42_05278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778102.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42502">
        <property type="protein sequence ID" value="OXR42502"/>
        <property type="gene ID" value="B7C42_05278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04623">
        <property type="entry name" value="CBS_pair_bac_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044725">
        <property type="entry name" value="CBSX3_CBS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="142" mass="15369" checksum="CC8B96245CF7203B" modified="2017-10-25" version="1">MRISEVLRNKGADVVTIAPEASVGRLLAVLAEHNVGAVVVCGAGGALDGIVSERDVVRCLHRQGAQLLTRPVSDIMTAIVHTCSPEDRVESLRATMTEHRIRHLPVVDHGRMVGIVSIGDVVKSAISELQDEREHLEHYLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H138</accession>
    <name>A0A231H138_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42566">
        <property type="protein sequence ID" value="OXR42566"/>
        <property type="gene ID" value="B7C42_05343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="68" mass="7199" checksum="45ECEE91ABAA61B9" modified="2017-10-25" version="1">MPDSPTSSAVAALIRWQDSGGVWRVLGRRGAHVTIGLFECTGGDEVDRIVSTDPALRAFVGQRAGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1B5</accession>
    <name>A0A231H1B5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase</fullName>
            <shortName evidence="9">L-Cys:GlcN-Ins ligase</shortName>
            <ecNumber evidence="9">6.3.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mycothiol ligase</fullName>
            <shortName evidence="9">MSH ligase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">mshC</name>
        <name evidence="11" type="ORF">B7C42_05417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26176"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778210.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42639">
        <property type="protein sequence ID" value="OXR42639"/>
        <property type="gene ID" value="B7C42_05417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035446">
        <property type="term" value="F:cysteine-glucosaminylinositol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01697">
        <property type="entry name" value="MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017812">
        <property type="entry name" value="Mycothiol_ligase_MshC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03447">
        <property type="entry name" value="mycothiol_MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="10">
        <location>
            <begin position="37"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="9">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="9">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="9">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'ERGGDP' region" evidence="9">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR42639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="412" mass="45450" checksum="7455D803296E920C" modified="2017-10-25" version="1">MQSWSEISVPAVPGSGPPLRLFDTADRQVRPVSPGATATMYVCGITPYDATHLGHAATYLAFDLINRILRDGGHEVHYVQNITDVDDPLFERAERDGVDWRELGTGEIELFREDMAQLRVLPPRDYIGAIESVGEVVELVDKLLAAGAAYVVDDAEYRDIYFRHDATEQFGYESGYDRATMERLFAERGGDPERPGKRDPIDALLWRAARPGEPSWPAPFGEGRPGWHIECAAIALNRLGPEFDIQGGGSDLIYPHHEYSAAHAEALVSHRRFARHYVHAGLIGLDGEKMSKSRGNLVFVSKLRRAGVDPSAIRLGLFADHYRTDRQWSDAVLEQAQQRLARWRQAAALESGPAAEETVARLRQHLADDLDTPKALAAVDSWVQQALEYGGPDTAAPGLVRTAVDALLGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1C3</accession>
    <name>A0A231H1C3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pepN_3</name>
        <name evidence="13" type="ORF">B7C42_05427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42649">
        <property type="protein sequence ID" value="OXR42649"/>
        <property type="gene ID" value="B7C42_05427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="244"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXR42649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="452" mass="49892" checksum="1D6F371840B5432B" modified="2017-10-25" version="1">MKLGRGGAEAPIDDYLPQNGNRGYRVSRYELDLVYKVAANRLTGRATITAVTTAVQPRFALDLSQTLSVAKVFVDGAKPAKYTHTRGKLTITPARQVPAGAALSIVVHYGGTPKPVRGPWGEVGWEELTDGVLVASQPNGAASWFPCDDHPSSKASYRISITTDSPYHALANGVLTARTTKSSQTTWVYEQSEPMASYLATIQIGPYRSHRIDPGRATKVPMTAVLPPRLRTVFDHDFARQPQMMAEFERRFGPYPFHGYTVVVTDDDLEIPIEAQGLSIFGANHCDGQRGAERLIAHELAHQWFGNSLTVRQWRDIWLHEGFACYAEWIWSQAGGGPSADQLARAARQNLARAAQDLVIGDPGPASMFDDRVYKRGALTLHALRLRLGDDAFFTLLRDWTARHRYGTVAAEDFTDLAGHYSPAPLRELWDSWLYRTALPELPQHGLGAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1F1</accession>
    <name>A0A231H1F1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_05015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051024364.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42679">
        <property type="protein sequence ID" value="OXR42679"/>
        <property type="gene ID" value="B7C42_05015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="36532" checksum="38955B52F1F23DD6" modified="2017-10-25" version="1">MSSTEPDRNRFVALPFTVVRKGYDRDEVRNYFDRFDAELRVTATDRDAAAAQARNLAAQLEDARDEIDELRKEVDRLSVPPTTAEGMSDRISRMLRLASDEASEVRAQAQAEAAEMISIAEQQATEMRGKYESLLAETKEKREALEVEFEQTLSNARAESAKIVEAAQADATRITKEAEAKRKAAQQDFEATMAEKRTKLTKAMEELEASSRSDAAQRIKEATDEANRLVTSATQSADRKIAHAKELAEEMRVLRGRVLAQLLGIRGQLDSVPAMLAAVNRESELLDGAPEQRSLSGKQSGAGRQKAIPEVKAEDEESVDEERESAEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1I1</accession>
    <name>A0A231H1I1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B7C42_05041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42705">
        <property type="protein sequence ID" value="OXR42705"/>
        <property type="gene ID" value="B7C42_05041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR42705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="202" mass="20884" checksum="60A012B1DEBF92FB" modified="2017-10-25" version="1">MARRVLVASRNAKKLGELRRILDEAGVAGLEIVGLDEVPPFPEAPETGATFEENALAKARDGAAATGLPCVADDSGLAVDALNGMPGVLSARWSGRHGDDAANNDLLLAQLGDVPDDRRGARFVSACALVADGREVVTIGEWPGTIARKPVGDGGFGYDPLFLPDGEKVSAAQLTPADKDAASHRGRALRALLPALADLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1P8</accession>
    <name>A0A231H1P8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_05113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42775">
        <property type="protein sequence ID" value="OXR42775"/>
        <property type="gene ID" value="B7C42_05113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="215" mass="23224" checksum="99575E3CFFC215AC" modified="2017-10-25" version="1">MDSATSDPRRTGVGDRPARAQAPLADTVRHGLKVVIVGGFGVGKTTMVRAVSEIRPLDTEATMTSMGIGIDDPTGAPAKSTTTVAFDFGRITIDAEHVLYLFGAPGQERFWFLWDRLFTGALGAIVLVDPRRITDSWYAIDRLEHQQTPFVVACNIFGPTSHDDTQLRAALDLDPHVPMVPCDARSRDSGKRVLIALVEHLHAAGLRAAARGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H281</accession>
    <name>A0A231H281_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Haloalkane dehalogenase 2</fullName>
            <ecNumber evidence="5">3.8.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dhmA2_3</name>
        <name evidence="5" type="ORF">B7C42_04841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.5" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42955">
        <property type="protein sequence ID" value="OXR42955"/>
        <property type="gene ID" value="B7C42_04841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018786">
        <property type="term" value="F:haloalkane dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR42955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="366" mass="40945" checksum="65C8F47730D763D3" modified="2017-10-25" version="1">MTVSGSAQIAPFRVDVSDDTLDDLARRLAHTRFADESCSEAGISTSYVRELVEYWRSGYDWRSWEGLLNSYPQYTTEIDGQMIHFLHIRSDRPDGLPLILTHGWPGTVVEYLDIVEPLTRAGYHLVIPSIPGFGYSAPLNDRGWNRQRTARAWAELMNRLGYHRYGAVGNDLGSTISLELGHLDSDHVTGVHVTQIFSTPSGAPGELTDLDPGSLDRWRRLQRFMATQGAYLTVHANQPHTLAHALADSPAGLLAWNAQLFGHGVDPDFTITNVMIYWLTETAGSAMGFYHEDSRSPAPSEPTSIPVALAEFTDDVFASIPRFAHRDHRNIISWNQFQGGGHYAAHQEPTRLANDIDAFYRRLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2A3</accession>
    <name>A0A231H2A3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42974">
        <property type="protein sequence ID" value="OXR42974"/>
        <property type="gene ID" value="B7C42_04860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="117" mass="13321" checksum="0551E551608C6BBF" modified="2017-10-25" version="1">MPYSPIDEDALLALPGICDLSQIELAHDLMQHHRTCRIDQCAWKQVAYRTLVHFRRVEPPRLSPRERAHRRGVEFPVGSGVSGSSRPNVVPIETFQQVLAGLTELANNMHPNVFRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2E1</accession>
    <name>A0A231H2E1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Release factor glutamine methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.297</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prmC_1</name>
        <name evidence="5" type="ORF">B7C42_04905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43019">
        <property type="protein sequence ID" value="OXR43019"/>
        <property type="gene ID" value="B7C42_04905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022446">
        <property type="entry name" value="CHP03704_MeTrfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03704">
        <property type="entry name" value="PrmC_rel_meth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="4">
        <location>
            <begin position="83"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="28636" checksum="45DA2AC90220C52A" modified="2017-10-25" version="1">MIDPESEESGTDAIVADLRRAGCVFAEEEAALLRQAASSSGELAALVARRIDGIPLEYLVGWADFRGVRVALDPGVFVPRQRTAFLIDEALERTAARPGDRRTVVDMCCGSGALGLAATTALRTGGVDVELVAADIDTVAVACARRNLEPLGAQVFQGDLFAALPGELVGRVDLLLANTPYVPTAMIARMPPEARDHEPRTALDGGEDGLDVLRRVADAAGRWLTVGGWMLVEIGTAQMDTATAIVAAAGLRPAIAESSDYGATVVCGTRTHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H322</accession>
    <name>A0A231H322_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43249">
        <property type="protein sequence ID" value="OXR43249"/>
        <property type="gene ID" value="B7C42_04671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="93" mass="10632" checksum="6A4D8E99ACD18D3A" modified="2017-10-25" version="1">MTEQGGNPPERADKDDHDLLTYSEVAVRLHEEVESLAQRARELAAAGESEELTRVEQRLAVLEAARDRNSRQPINDDNFEKFFGYKGFARRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3Q1</accession>
    <name>A0A231H3Q1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779264.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43498">
        <property type="protein sequence ID" value="OXR43498"/>
        <property type="gene ID" value="B7C42_04365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23271" checksum="91D84CD8E0386D8D" modified="2017-10-25" version="1">MTAAMKEPRSSENPPAAGVVAPAESRRAPIWDRPVPGAGRAPLVWLLGVHGGAGASTLAHVLAPAADSHRRWPGVFERESPFVVLVARETIAGLTRAHDLLRQHRAGLAGPSEVLGLVTVAARPGRIPAEIRRYRDVVGALAGQVWQMPWIEEWTLVEPDQLPVWSPSDPPPQQRKRKLDPLQEVPHEVDALGMSIVDLVRETVGAGSQQEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4G3</accession>
    <name>A0A231H4G3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glkA_2</name>
        <name evidence="1" type="ORF">B7C42_03945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780377.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43710">
        <property type="protein sequence ID" value="OXR43710"/>
        <property type="gene ID" value="B7C42_03945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="307" mass="31400" checksum="8CB1CEF9479A887E" modified="2017-10-25" version="1">MREAGKLDPVLAMDVGGTTIKAEISDADGRIAAAATVPTPPGERAFDAMAELGDRLLSEVSSGTRAGVRRGAIALPGIVDAARSVAVFSSNIGWREVKVGSRFQDRWGFPVLIEHDVAVAGWAEWRLGAGRGADDVLVVNLGTGISGALIVGGRLVRGGAGQAGEYGHIPVRRDGRRCSCGNIGCVETVASGPSIARAYRERTGRDIDSAEAVFAIAPDDAHARAVIADAIDALADGLLGVVHAVCPQRVVIGGGLAGAGPVLIDGLRARLERLVRVAPVPEVVAGAFGARAGLVGAARYARLGGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4L8</accession>
    <name>A0A231H4L8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 17" type="primary">hemA</name>
        <name evidence="17" type="ORF">B7C42_04022</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43787">
        <property type="protein sequence ID" value="OXR43787"/>
        <property type="gene ID" value="B7C42_04022"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="173"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="326"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXR43787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="462" mass="48277" checksum="AB46956FC6265581" modified="2017-10-25" version="1">MSVLLVGISHRSAPVAVLEKVAVTEEDRPKLTDRMLASQHISEAMIVSTCNRVEIYAVVDAFHGGLAEVGDLLARHSDLPLPELTKHAYVRYSEAAAEHLFAVASGLDSMVVGEQQVLSQIRSAYAAADAQQAAGRTLHELAQHALRVGKRVHSETGIDRAGASVVSVALDRAANVLGDLAGRTAVVVGAGAMGGLSVAHLARAGIGRIIVVNRTLARAQRLAHTATTMHGAPATAMELSNLVSAMADADIVITSTGAVGSVVSLADAHRALNVSRAGHQMVICDLGLPRDVDPAVAGLPDITVIDMETLQRDPAAGAAADDTSAARALVAEELAKYLSGQRMAEVTPTVAALRQRAAEVVEAELMRLESKLPDLGDPQREEVARTVRRVVDKLLHAPTVRVKQLASAPGGGSYAEALRELFELKPGAAQAVAAPMEIATLGGELADDFTTSHLGDEQGHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4R3</accession>
    <name>A0A231H4R3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">menG_5</name>
        <name evidence="4" type="synonym">menG</name>
        <name evidence="5" type="ORF">B7C42_04080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43845">
        <property type="protein sequence ID" value="OXR43845"/>
        <property type="gene ID" value="B7C42_04080"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="214" mass="23630" checksum="F645986CCB67549D" modified="2017-10-25" version="1">MFDGVAKRYDLTNTVLTGGQDRYWRWATRRALALRPGERVLDLAAGTGVSTAEFAKSGAWCLALDFSKGMLEAGRFRRVPMVNGDATALPFADDSFDAVAISYGLRNVSEPDAALREMLRVTKPGGRLVVAEFSTPVFGPFRTIYMEYLMKVLPKVAEAVSSNPDAYVYLAESIRAWPNQRQLAMRISDAGWSSVQWRNLTGGIVALHRGYKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5C9</accession>
    <name>A0A231H5C9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43936">
        <property type="protein sequence ID" value="OXR43936"/>
        <property type="gene ID" value="B7C42_04175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="29" mass="3036" checksum="1F36D77F16184AF1" modified="2017-10-25" version="1">MDGTVDYAAIITQVLSFLSSGSSIAYTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5N0</accession>
    <name>A0A231H5N0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tdcB</name>
        <name evidence="7" type="ORF">B7C42_03874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44313">
        <property type="protein sequence ID" value="OXR44313"/>
        <property type="gene ID" value="B7C42_03874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="368"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="443" mass="46132" checksum="57002A1F1BCC6A42" modified="2017-10-25" version="1">MWVQLPRLVPILRSGSHLPPARPALPGFAATVWQHGRMELIGFDRISAAQKMLAPVIRRTPVIASRVLSERTGADVRLKCENLQRTGSFKPRGAYFRIANLAPAERTHGVVAASAGNHAQGVAWAATTLGIVSTVFMPVGAPLPKLVATRAYGATVHQVGETVDEALLAAQEFAERSGATLIHPFDHPDIVAGQASVGSELLEQFPDVGTVLVPTGGGGLLAGIAAALHPVAPQVRVIGVQAALAAAWPDSLRSGEPVALQRMSTIADGIAVGRPGEVPFAHVIAHQPTIVTVGEDALSAAVLLCLERAKLVVEPAGAAAVAALLSLPADELRLRGPVCAIISGGNVDPILLTRIIGHGLSTGGRYLAVRITISDRPGSLSRLLDAVAGTGANVLDVVHARTPAGLAIDEVEVQLTLETRGPAHRDDVLDALDRAEYAVRVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H646</accession>
    <name>A0A231H646_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775854.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44483">
        <property type="protein sequence ID" value="OXR44483"/>
        <property type="gene ID" value="B7C42_03272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="249" mass="28610" checksum="79F1AA21F1D9C60B" modified="2017-10-25" version="1">MTETNRGRVRTEAGHRRIRAYVGGHVVADTIRPLLVWESPYYPMYYVPVEDVRAELVATGSTKHSTSRGEGDIYDVVIGDTTRPAAALRYPESPIPELREHIRLEWEQMDRWFEEDEPIYVHPRNPYTRVDILASSRTVRVELGGEVVAESNSPHILYETGLVPRYYLPLTDVRMDLLTPSATTTSCPYKGTAEYYNIRVGDTDYPDLVWYYRTPLPESQKVAGLVCFYNEKVELYVDGVRQEHSTPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6T7</accession>
    <name>A0A231H6T7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44733">
        <property type="protein sequence ID" value="OXR44733"/>
        <property type="gene ID" value="B7C42_03528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="151"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="284" mass="30077" checksum="2FE80E7C6F289670" modified="2017-10-25" version="1">MASKAPVVVGVDSSDDALRAARWAANDAALHRVPLEVISAVPPVPQDRAADEGVHAYHERSREQAQRAVAEAARVAADIAPKIDIDTAVIDAPIIPALLSQADEARLVVVGARGLGAYQRSLLGSVSTALVRHARGTVAVVPADPLLGSERPVLVGYDDSPCSAQALAIAVDEARRRQTDLVVVHTWQRFGDYPSPAALEEEGNRLLDDALAAHEDPDEPISVRRVVVEDRPVRRILDESAAAQLVVVGSHGKGGFPGMTLGSTSQALMHSVECPIVIARPRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6V3</accession>
    <name>A0A231H6V3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pstS3</name>
        <name evidence="7" type="ORF">B7C42_03401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44611">
        <property type="protein sequence ID" value="OXR44611"/>
        <property type="gene ID" value="B7C42_03401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013211984" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="33"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="48"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR44611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="370" mass="37916" checksum="05C1994C62ED7681" modified="2017-10-25" version="1">MNFKRSGALLGVLAAAGTLTLTACGSDDNSSATGNTSKVDVACGGKKALKASGSSAQKNAMDRFIAAYEQNCDGAKLDYTSSGSGAGVNEFVGGQTDFGGSDSALDPKKDEPKKAADRCGAPAWNLPTVFGPIAVTYNLDGVTNLTLDGPTAAKIFNGTVTKWDDPAIKGLNQGVNLPSDPIHVIFRSDESGTTDNFQRYLDAASNGAWGKGAGKAFAGGVGEGAKGNEGTSAAIKSTKGSITYNEWSFARSQNLSTAQIITDAAVKPVALNAESAGKAIASAKIVGQGNDLIIDTNSFYKPTDPGAYPIMLATYEIVCSKYADADTGKAVKAFLTSAITNGQNGLEDSGYVPIPDAFKTKLTTAINAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7A5</accession>
    <name>A0A231H7A5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfB_10</name>
        <name evidence="3" type="ORF">B7C42_03534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44739">
        <property type="protein sequence ID" value="OXR44739"/>
        <property type="gene ID" value="B7C42_03534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="57"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="455"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="544" mass="58403" checksum="815F43553F561F96" modified="2017-10-25" version="1">MTVNLLRTLITRAWAELEYLRLAVGSGVVGIESPLTLLSAGDALLRHGALPALLRLAAARYGDRAAVIDELGTLSYRELEDRSNRLANEWRKRGLRTGEGVAILARNHRGLLDAVFAAAKCGARIILLNTDFAGPQLRDVAAREGADLLVYDEEYESILGDLSPRRGAYRAWSETGHTSSLESLITAGSPATPPISRSGAKIILLTSGTTGTPKGAPRSEPRSLEPLGAILSKVPFRTREVTECPAPLFHTLGFAMSLLAIGFGSTLVIRRRFDPQRVLDSMAEHRATALIVVPVMLARMVESGPQAVRERDLSALRIVFVAGAQLGAELCRRVTAAFGPVVYNLYGSTEVAYATIATPEDLAVEPGCVGSPVVGAVVEILDEQGEPVPPGTSGRIFVRNAIPFDGYTGGGGKERIRGLMSTGDVGHFDSAGRLFIDGRDDDMIVSGGENVFPAEVEELLDAHPDVREAAVIGVPDDEYGARLVAFVVRITETLGAEEIKAHVKANLARYKVPRDVVFIDELPRNPTGKVLKRRLREWGEGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7H7</accession>
    <name>A0A231H7H7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44798">
        <property type="protein sequence ID" value="OXR44798"/>
        <property type="gene ID" value="B7C42_02752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="39610" checksum="7E339023B63E9892" modified="2017-10-25" version="1">MVTATNSVVTLKDLIGVLDGAYPPRLAESWDSVGLVCGDPAASVSRVLFAVDATAAVVDEAIGWGAQALVVHHPLLLRGVDTVAASTPKGALLHRLIRSDCALFTAHTNADSADPGVSDALAHTLGLTVTGPLEQKSTAPVDTWVVFVPRAHTDAVLAAMFEAGAGGAGFYRECGWRVPGTGQFRPMAGANPAIGQVGDLEFVEEDRVEVVAPPSARAAVLTALRAAHPYEEPAFDVTERAALPSAQGLGRIGTLPEPETLRAFTARVRAALPGTAWGVRAAGDPEREIRTVAVCGGAGDSFLGTVAKLGVDAYVTADLRHHPADEHLRAGGPALVDVAHWASEFPWCAQAEGVVREALPGVETRVSTLRTDPWTLGAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7J8</accession>
    <name>A0A231H7J8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] synthase 1</fullName>
            <ecNumber evidence="5">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kasA_2</name>
        <name evidence="5" type="ORF">B7C42_02860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784171.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44904">
        <property type="protein sequence ID" value="OXR44904"/>
        <property type="gene ID" value="B7C42_02860"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="14"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR44904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="416" mass="43359" checksum="9431C3BF5EE6FCC1" modified="2017-10-25" version="1">MTTPSTLNGNFPNVVVTSLAATTSIAGDVDATWKGLLNGESGIDVLEDSFIEEYDLPVRIGGHLKVSPDTLLSRVEIRRMAYVERLAMVLGREVWKNAGSPEVDPERLAVAIGTGLGGGDALIDSVDKLKNGGYRKISPLAVQMVMPNGPSAVVGLELGAKAGVVTPVSACSSGSEGIANAWRMIVMGDADMVVTGGVEGYISDVPIAAFSMMRAMSTRNDDPKGASRPFDKDRDGFVFGEAGALMVVETEEHAKARGATIHARLLGAGITSDGFHLVAPDPTGAGAARAMERAMQTAGLSKSDITHINAHATATPIGDTAEANAIHKAVGKHASVYAPKSALGHSIGAVGALESVLTVLSIRDGIVPPTLNLENQDPEIDLDVVHGEARRQDIEYAINNSFGFGGHNVALAFGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7K9</accession>
    <name>A0A231H7K9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44914">
        <property type="protein sequence ID" value="OXR44914"/>
        <property type="gene ID" value="B7C42_02870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="167" mass="17492" checksum="3722A74849F156CD" modified="2017-10-25" version="1">MTVRVRHSGTMTNPKGDSGRKPGGARVPGATEILAAAQAAAQAAQTAAGQAIDAAQVTAGTAFGTAVRLPPASVQLAAQLPDLIENLATAIDRLNSTIDRLDRTLALADPAFAAYDRLLPRLEAVIALGEDVLSRLSKLPGISMLGRLTSREAEPPQPEPKSRRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8F3</accession>
    <name>A0A231H8F3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">General stress protein 39</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ydaD_2</name>
        <name evidence="1" type="ORF">B7C42_03108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45151">
        <property type="protein sequence ID" value="OXR45151"/>
        <property type="gene ID" value="B7C42_03108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="258" mass="26473" checksum="F5F514CFFB501D1D" modified="2017-10-25" version="1">MSKRLEGRTALVTGGSRGLGAAISRQLAGDGATVAVHYRTEADAAREVVAAITSEGGRAVAVSGSMGDFAAVDRLVDDTVAAVGPIDLLVSNAGSASRGRSVVGSPDDEYERLLRIHALGPIHLVRRVIDGLRSAPRGDIIAISSSTVADAPPFAAPYTIAKSALETAIRTLAREERQHGIRANIVAPGLIDTDMGQRLVRAKTGSDIAGVGSQSPFGHVCQPQEVSGLVAFLASAEGGYITGQRITVNGGGQDPGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8H9</accession>
    <name>A0A231H8H9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45181">
        <property type="protein sequence ID" value="OXR45181"/>
        <property type="gene ID" value="B7C42_03139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012691980" evidence="3">
        <location>
            <begin position="44"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="501" mass="50489" checksum="88BA30F631F879FE" modified="2017-10-25" version="1">MTPTPAPAHRRARTRCAAPTLICAIVAAVVTAVSALVCGAATATPVSGPPSCPRWTAMLVPGTGEAQPTDERGGMLAPIGAGLRQRYDSDIEVRTLTYPASAVPYSTSETAGTQNLSTLLHGLCSSTQVVLAGYSQGADIAGDLATEIGNNRGPVPASRIVAVALISDPRRSSGTPQLGTPSPGEGIAGPRRHDFGTLADRVRTLCATGDLYCSTSPQASPALAALGRAFTGTDLPPTSNDTTKHPSPDQTTTSATAPVTSSRAAPDSGLDASGSFAGLDPSEIIGQVVAVLSGLSGFAADLPAIGNDLAQLPALIASGNLPGLHQISGDLNNQFAPLVQMADRIDLHLVARALALAAPLDTSGWTAVAAQIVNILAGLDIGRLATDIGQAQEIAWNAAQKLVTGDPAGAALALSGLVPVAADLAAAAASALTGDAGAHLTGLAHTFTATTTPDTSTALADLARQSGDATRFATSGVHQNGYSTALEQALDWLINRIDTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8R9</accession>
    <name>A0A231H8R9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenoxybenzoate dioxygenase subunit beta</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pobB_2</name>
        <name evidence="8" type="ORF">B7C42_03044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45087">
        <property type="protein sequence ID" value="OXR45087"/>
        <property type="gene ID" value="B7C42_03044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="52"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR45087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="363" mass="39551" checksum="EDD10413B9A48508" modified="2017-10-25" version="1">MTAVAYPVAADRPEYRPSLPLRAVGAVFDLYRRGVTTEPPIEVLSRPNPVRRSGFERELIVARRETQPGDVVVLTLVAPYGGQLPRWVPGAHIDVFLPSGRQRQYSLNGDPADRGSYRIAVRHLPEGGGGSDEIHRDVAVGDRLRVRGPRNAFGYIDAPHYVFVAGGIGITPLLPMVADAERRGIDWRLVYLGRSRATMPFLDELSAHRGGLLEVRPDDEFGLADLDLILADVPRGTAIYVCGPPPLMAAALSTDAAHEPTVSVHTERFSPLPVRRGRPFRIRLRRSGHTVDVAADESALAAIGRVLPDVAYSCRQGFCGTCAVTVHAGAVDHRDRRLSPAERETTMLTCVSRAAGDTLELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8S9</accession>
    <name>A0A231H8S9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane protein YbjJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybjJ_1</name>
        <name evidence="7" type="ORF">B7C42_02356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45231">
        <property type="protein sequence ID" value="OXR45231"/>
        <property type="gene ID" value="B7C42_02356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="451" mass="45911" checksum="318AD150711A42E5" modified="2017-10-25" version="1">MHSSVETTRRGTVAPAARRARAAVFAVFALNGFLAAMWVVHIPVITDRTGVSHGTLGILILVMAGSGIVGMQAAGPLADRFGSRTLVTAAVAWLIVAVSGPAWATGPVQLGIALAIFGFGNGALDVSMNAQAVQVERVYRRPIMAAFHALFSCGGLVGSLAGAAAMHAGADIRMSFAVAAVLGLLVMLASVPSLLPRLHATSHVEPAATVAESAAVPDHSAAENGVAVTESAAALPAAGAPASGSRTGRRATDSAVRRRVRHWLPPKVLALAAIAFALLMAEGVANDWSALQTHEHLGVSDATAALSFGAFSIAMTVGRFTADRVSERFGRIAVVRWGSVLGAAGLAVIMASPWLPLSLAGWILAGLGLAGGVPQIFTAAGNLSTATAATDMSKVFGLGYLGFLAGPSVIGWLAQLTSLTLAFTFPLLAVLLCAWFAGTVGEGAPAEHVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9N7</accession>
    <name>A0A231H9N7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784073.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45664">
        <property type="protein sequence ID" value="OXR45664"/>
        <property type="gene ID" value="B7C42_01956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR45664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="127" mass="14097" checksum="EFAD13AECB54C71B" modified="2017-10-25" version="1">MATNGPFGIDPEEFERALREAEIEVRDLLGKAAGYLDRTTVNSLTSLFGQFVRPDHTRSPEPDDATTGETGSGVWAVYSVDDAGEARVEQVFPTELEALRAHRDNTDERRKVRFLPYGVPTSVLDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9T8</accession>
    <name>A0A231H9T8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45625">
        <property type="protein sequence ID" value="OXR45625"/>
        <property type="gene ID" value="B7C42_01917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="175" mass="19364" checksum="D2916A64A6EAE134" modified="2017-10-25" version="1">MSDMTLREMEEVLLAHEIAELEQDVEATMATLAPNPHYELAFVGLAVDGEDAVRETYRRILSGNQGRDVAAEARVYGVAANTLMREAHMTFTTRQGERVNGLYLVVMSFDPETKLICGERMYTDPLVGEMMTEQLGANFESLPGVTRIRDTAPTIAQHDAFRDAEAQGRSINVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Y9</accession>
    <name>A0A231H9Y9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45675">
        <property type="protein sequence ID" value="OXR45675"/>
        <property type="gene ID" value="B7C42_01967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="305" mass="30163" checksum="126002F1BECD5499" modified="2017-10-25" version="1">MNQSLTYGLPAVVVAAALYGCAPVVQAAAARQTAPGGGLGLALLARLAVRPLWLLGLSCEIGGFAAEAYAFSIAPATLVAPLLTLDMVFLVVLARRGLGERLAVVGRYGIAAMVLGTGLMAYAFAGESSLGSPASDAQMVLFAVVGAVAAGAGAVAGDLGSRTGRASVAALGFGAAAGIAYGIATVATRQFGLTFDVHDPWRLLATPTPYVLAVCSLLAISLLQRGLQAGAAVLTFPVTSVVSSLVPVALGIAVLGDEVPGGRAGAAFAVALVAISVGVTCLGRDRAAAARGIETATDLTTRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA09</accession>
    <name>A0A231HA09_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4173 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_02000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45708">
        <property type="protein sequence ID" value="OXR45708"/>
        <property type="gene ID" value="B7C42_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="3">
        <location>
            <begin position="381"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="606" mass="63576" checksum="FF01286BF409AAB7" modified="2017-10-25" version="1">MPEEPTPDRTRTPEPVDSAAHDRPARSGASSEPERAGTPPDLDGPLGPDVPEVSDDQVTPAPASPAASAAKPVAPQPCSTADTTVGNGVGDTTGGASNDDRLTAGSGAWLPGQAPGPQHFRSGRQWAPGDPGSAPPVPPHRRRVVYPAGVLPAAGVAGLVAAATVPLDRPGIGWLLAGSVTAVAVGTVHRRATDRSDTPAERRIRPGRWWTAAALALLAVGTFRAAGWLFVLCVIAAAVCGSLAVVGRPSARGVFHDAIAVPLASAGALAWVYAAQGRRRGSTGARHWRLGASVVATVVILAVFVPLLAGADATFAAIVTGLVPRTDAATTTRWIVLFLLAGTATLGALYLLAGPLAPAEAQRAPAKRTLARLEWALPVGALTVLFASFLGAQLVALFGGDDYVQRTAGLTYADYARSGFWQLAAVTLLTLAVILPVLHRATRDSARDRFWLRGLLCAISGLTLVIIASAFGRMWTYQQAYGFTVLRLLVGTCELWLGVVYLLVIVAVLRLETAWLPRTTLATAVAALLVLAVANPEALVASENIDRWQRGEELDVDYLSGLSADIVPVLDRLPAPIRLDLRQRLTHGPDDETWNSWNLARMRAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAL2</accession>
    <name>A0A231HAL2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">csd_1</name>
        <name evidence="4" type="ORF">B7C42_02287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45994">
        <property type="protein sequence ID" value="OXR45994"/>
        <property type="gene ID" value="B7C42_02287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012533934" evidence="2">
        <location>
            <begin position="24"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="80"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR45994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="474" mass="50302" checksum="34718FC9ABEDAD49" modified="2017-10-25" version="1">MVASVRAEGSVTLRSPTPLPAHAHPASAPASAHTPAHVSARIPAPPACEPPGPASIETAAARDPGAVRDLFPALTGDGPVYLDSAATTQKPLPVIEVIEGYHRRHTANSGRGTYPWATTLTRAIEQVRADTARFLHAEPDEVVFTAGATAGLNAVALAWGLTTLTDGDEILYSPRDHASNVYPWLQLRATLAHFGRRVRLVPYRTTALGEADIDDIAAKLGPRTRLLTVSHLHHVYGARNTLEELRGGLDPRVAVCFDCSQSGGHIPVDVRELGADFAVLSAHKMFAAPGTGVLFCHRRIHDQLGPFLPGGNSGVSVRDSALRPARMPQRLEGGTHNIPGILALGAALRVLDAIGIDTIEQHNRMLTRRLVDGMRALPGLRLLPGPAHAPCDTGYGIVSFTLDGITATDLGFVLSELGFLVRTGAHCVPSDTADDAELVAAEADSVRVSTHVYTTAEEIDRFLGCLTTIATEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAQ4</accession>
    <name>A0A231HAQ4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45931">
        <property type="protein sequence ID" value="OXR45931"/>
        <property type="gene ID" value="B7C42_02224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="32378" checksum="DA160A0259AF1291" modified="2017-10-25" version="1">MACDQLIHRYCAEVDIALEWDQHPGTGLRLAAELAGRTGLPLLEDISVADGTADLLGVIAARGGGELLGWAELRDAGLGEAWVQAVSAQRLVHSLHLGRADESEPQAAETEMVCRLTAEAVRRATAAGYRVLRWQGTDIGPSGRAAVELGARRVDEYARLWELDLTRPPVPDTSAPLQRLVHTLAESADPPGRVLLTTVLSARSATEPITTITTFAGGAEAYISAEEGFAHREADADLLTAAFGAVVAELRAVMPDITMLRVFEFDDEALRAALARIGMRVCGRYNDYELNLPESPTGEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB50</accession>
    <name>A0A231HB50_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase FadD15</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46059">
        <property type="protein sequence ID" value="OXR46059"/>
        <property type="gene ID" value="B7C42_01022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="597" mass="64438" checksum="D9F7BD67FC3FB076" modified="2017-10-25" version="1">MHEFSLPALYDVPAEASLGDLVYRNAELHPDLGVIGLKRDGRWHDMTAAQFLAEVRATARGLIAEGVGPGDRVAMMSSTRYEWTLFDFAVWCAGAVSVPIYPTSSAEQVQWILSDSGAVAVVTETNVHTAVVNKVHEQVPDLAHIWEIEAGAVDVLTRAGTEVDDAEPDRRRSAVGPDSLATIVYTSGTTGRPKGCGLTHGNLLAELGNTTARLPQLFRTGESSILLFLPLAHVLGRIAEIAATLVPIKIGYVADVKDVTAELGTFRPTLILGVPRVFEKVYNGARSQAQLTHRGRIFEVAAATAISYSRALDRGHVPWHLRVRHALFDRLLYSKLRAALGGRATHALSGGAPLGARLGHFFRGVGFTVLEGYGLTETSGAITFNPDDQPKIGTVGQPAPGCAVRIDDDGEILLRGPSVFTGYWHNPAATEATFRDGWFATGDVGSLDAEGYLTITGRKKELIVTAGGKNVAPAVLEDRIRSHAIIGEAMVVGDGKPFVSCLVTIDTEHLPTWKQLHGKPAEATLADLYSDPDLLSSVQDAIDEGNRAVSQAEAVRKFRLLRTEFSEANGYITPSLKLKRNLVLRDFADEIEELYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBP6</accession>
    <name>A0A231HBP6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-(1-&gt;3)-arabinofuranosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aftD</name>
        <name evidence="3" type="ORF">B7C42_01208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.47" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46242">
        <property type="protein sequence ID" value="OXR46242"/>
        <property type="gene ID" value="B7C42_01208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021798">
        <property type="entry name" value="AftD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11847">
        <property type="entry name" value="DUF3367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1486"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1553"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1592" mass="166026" checksum="FD46D204A1CCB363" modified="2017-10-25" version="1">MSTARADAAPAAAPSADSRSSATAPLGRRWFAGTVLVAFLLTFLQAPGNTVADTKYDLAQNPVGFLQRAAHLWSSQAPMGQVQNQAYGYFFPHGAFFSLGHVLGLPAWVTQRIWWALLILAGFWGIVRLCEVLGIGTRGSRVVAAVAFALSPRVLTTLGSISSETLPMMLAPWVLLAPAALGVVGMPRIHAARSGWRRLLPHRPTAESVSMRGATSPAASALALALMGSVNAVATVAAFLPAALWWASYRPDRTWWRFTRAWIPLLILGTFWWVVPLLVLGKVSPPFLDYIESSGVTTQWASLGEVLRGTDSWTPYVSPERIAGAVLVTQPAAVLATGALAAAGMAGLAMRSMPGRGRFALVLIAGLVGICAGYAGQLGGPFAESVRIFLDSGGAPLRNVHKLEPLIRIPLVIGLAHLLRRVPLPASVPMPVWRSAFAHPERNRMVAVAALLLAALALSTSLAWTGKLAPRGAYDKVPAYWQQTADWLAHNASDTRALVVPGAPFGSQIWGLTRDEPLQALARTPWAVRDAVPLTPPGAIRAMDSVQRLIADGRPSTGLAPTLIDQGIGILVLRNDLDPDTSRSTRPMPAHEAIEGSPGITKVAEFGNPIEVGHGDGLVADGDLRPTYPAIEIYRVSDGDSGQPADIRSGPGAPASFPGARTVPLNSVPVVQGGPEVLERLRRNGSGTSGPTLLAADAARAGLTPSATTITDTPMDREADFGRVDNHNSALRAPTDARRTHNLVPDYPVPGAQPVEGQWSGATVTASSSAADATQLGGAAPGSSTAAAFDGDPSTAWLSTSAEHAVGQWLRLGLDHPIRAGALQVTTSPAAIGDPVKWIEVRTANGTVAARISEPGAPVSVSLPPGRTDWLTITATRTENGTGGGQFGLSEVQLFDYSNRDAPTPVTIRHRTVLPPVPAGTPVRGWNLGQEFPGRSGCFDAPDRVRCSKGLALPAEEPGAFERTLDVPDPMTVAPRLTLRTRQGPALESLLTDPERPIARGKADVGDLRGSAFAATDGDPRTSWIAPEDTVRNRTGAKPTLTVQLPRPELVTGLEVTPPMGALPARPTSIAVNLGDGPQVREIPPAPKGRDPESTAESPGRTSPTATPPRDAPAPQPKSTDTPAPMSAPPTPVRLELHPYVTDHIEISIDTWKPVLDRTALGLTQEQPPGLAEVSVLGPDYPAPAAGDRSVTVDCDHGPTLAVAGRVLHTSVTATADELRTGKPVSATVCAPGDTGNGGETVGLPAGSVDVTVAPTELFSVDELRMDNTAFEGGTAVDRPAPESAGGADRPAGIDAPAGDRLLVLPLSTNVGWTAHTGDGHTLRPVVVDGWKQGWVLPADAHGPVTVGFPIDRWYRLAIFGGLLLLIPLALLALPVPGRLRKWLRHRDNDHHAAHLPVDETAPLPTEDRTPGDTALSAADSRAPGDGAPTTGDGALAHGIGDGTTPRPHGASSTSDDHTDNPVTAVPAQASSAVSYDPPPRTWNSWWLGAVGVLVAAFLIAGPIGTVCAAIGVVAVRVLPRAPLALAVLAGAGTILGEAALSTGPWRSGEVYMGGSLWSQFPALVAVVAVGVAALPARKPWGRVGSTTRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC58</accession>
    <name>A0A231HC58_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043457.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46399">
        <property type="protein sequence ID" value="OXR46399"/>
        <property type="gene ID" value="B7C42_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="349" mass="39510" checksum="28FB0CC67AE151C5" modified="2017-10-25" version="1">MTLSKSIRTDIFGPDYREMLAILSEGSVHRNFDPYLDIDWDSPELAIDPDDPRWVLSPDLDPLGGTDWYKSLPLERRIEIGKWRTANVIKVGAAFESILIRGMMQYIMKLPNGSPEFRYCLHEMTEECNHIQMFQELINRIGVDVPGMRPLFRALSPFIGVAGGYAHAILFIGILGGEEPIDHYQKAIIREGESMPPAVLRTMQIHIAEEARHISFAGEFLKAHIERMSPFGKAMCALAFPITMRWLAGEIMAPPRSFAKEFDIPREVIEDAFWRSPNSRRILSGYFGDMRKLADELGLMNPVTRKLWTLLHVDGDTSRYRGEPDRRNAAAAVAERLPVVGSLVGWLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCE7</accession>
    <name>A0A231HCE7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="21">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="21">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">lysX_1</name>
        <name evidence="21" type="synonym">lysS</name>
        <name evidence="25" type="ORF">B7C42_01472</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="21">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the LPG synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="21"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46502">
        <property type="protein sequence ID" value="OXR46502"/>
        <property type="gene ID" value="B7C42_01472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 21" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="18" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="24">
        <location>
            <begin position="808"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="608"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1040"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OXR46502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1135" mass="125254" checksum="9261A458A33B839F" modified="2017-10-25" version="1">MTVHEQDSPGGLLPSSGPSPHTGAVTSTQDQLHSRDRGSPSSPVPHRAHGRLSEVPHLVGLVLGVFSILCALWSISPGLRYITSVPRHYLDAYYFDAPDTNLMWAVIVGLLAGATASRKRIAWWLLVGYMALFALANGLDFAEEQDPHALAALFVHLAVIGLMIAAWPEFYTRVRRGAVWKALGVLVSGLVISSLLGWGLVELFPGSLPRGAQRPLWAVSRVTATILVADNNFDGHPPHVVNLLLGLFGAIALLAAALVLFRSQRASNAMTGLDESAVRGLLARSDVEDSLGYFATRRDKAVVFAPSGKAAITFRVELGVCLASGDPIGVREAWPQAIDAWLRLADEYGWAPAVMGAGELGATAYRRAGLSALRLGDEAILDTRSFSLAGPEMKQVRQAANRLHKQGFTVRVRRHSELSPDEMAQMIARADSWRDTETERGFSMALGRLGDRLDGDSLLVEALDRDGRVWGMLSLVPWGRSGVSLDVMRRDPKGPNGIMEFMISQLALTSEQYGITRVSLNFAVFRSVFEEGGRIGAGPVLRLWRSVLMFFSRWWQLEALYRSNVKYQPQWVPRFFIFEERRQLPRVALASALAEGFLPRFGTQPDASAHTGLHSAVPPTLTGLHADGSPPEAPPSELEQAAARRPEQVRVRMDKVRRLESADIDAYPVAYAPTHSIADARRSPKGTTVRVCGRLLRIRDHGGVTFAELRDWSGDIQILIDRDRVGARRSRSFGEYFDLGDLIEVSGQIGTSRRGELSLLAQDWRMIGKCLHPLPDKWRGLADPEARVRQRYVDMTINVEAREVLAKRSAVVRSLRDTLNGWGFLEVETPVLQQVHGGANAAPFRTHINAYDLDLYLRIAPELYLKRLCVGGMEKVFELGRVFRNEGVDYSHNPEFTILEAYEAHSDYERMMHACRQLIQNAAIAANGACVALRPDADGTLTEVDISGDWPVRTVHGAISDAVGETVTPDTPVERLRLLCDKVEVPYQPGWDAGQIVLEMYEHLVEDRTLEPTFYIDFPTSVSPLTRAHRRIDGVAERWDLVAWGVELGTAYSELTNPIEQRRRLTEQSLLAAGGDPEAMELDEDFLEALEFAMPPTGGLGVGVDRVVMLITGRSIRETLPFPLVKPRTGQGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCF3</accession>
    <name>A0A231HCF3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039775051.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46488">
        <property type="protein sequence ID" value="OXR46488"/>
        <property type="gene ID" value="B7C42_01458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="330" mass="35277" checksum="C564428614C563B8" modified="2017-10-25" version="1">MDVDAYSFAQRRHWDRLDRLTAQRRLSGAEVDEFVALYRRTSQQLARLQSHSPDPELINGLSAVLARARGRLLGARTDTWSQIGYFFTHRFPAAVYRAWPWWAGVAAAFLAVSTGVGIWVSGSGSARRTLGLPSDAASLTAPGGRFESYYSEHPHDAFAAQVWTNNAWVSAIALFTGILILPAAYLLFMNALNVGVSAGLMADAGRLDSFFGFLLPHGMLELTAVFVAGGAGLKLGWTLIDPGRSSRAEALARQGRATATIALGLVAVLLVSGLIEGFVTPAGWPAPVRIGIGLVAELGFLTYVFGAGRRAAQESAALRATADADERISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCQ3</accession>
    <name>A0A231HCQ3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46566">
        <property type="protein sequence ID" value="OXR46566"/>
        <property type="gene ID" value="B7C42_01537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="199" mass="20117" checksum="2A6EF42F5D8AC637" modified="2017-10-25" version="1">MSYPYGPGYGGNGYPPAGYPPGYPPAGYPAPGYAPYGYQEPRPSGGAAITAGVFALLLALLAAFGIIGLLSAASSVSHSYGSYRSHNSGSADIFYIMAAVDGVIALLWAVGGIMLMNHKNAGRVMLVALSSLGLLGGLAGIVMSLANGVPAASIGGIVGLLFAVLMLSLTLSGSAKRWCGVGMSAYPPAAYYGQPPYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HCS2</accession>
    <name>A0A231HCS2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46721">
        <property type="protein sequence ID" value="OXR46721"/>
        <property type="gene ID" value="B7C42_01698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="198" mass="21885" checksum="1A24FF993F9A0C4B" modified="2017-10-25" version="1">MRTATRDDITGMVRVLAAAFAHDDPIEEYVFPDETVRHRRAPRMLRTMIEHRFLPAGGAEVAELDGRIVGALLWYPDGYRPGGLREFLAGPLFLAGMGTAVGRGTEVDRTMDRAAPAEPHLFHVYLGTDPSLQRSGVGRALYASFTDKADRQGVLLCGICKDENVGYYEALGNERTGSVRLGRTGPEMNIMIRRPRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD14</accession>
    <name>A0A231HD14_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46658">
        <property type="protein sequence ID" value="OXR46658"/>
        <property type="gene ID" value="B7C42_01633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="109" mass="11551" checksum="1CA9F6C5B099DDA6" modified="2017-10-25" version="1">MSVVDQALVDMRNGGRVLVVAPTQSAAVALFDNASRRLTDGETGHRSHSPRIRGAGEGWIQFQSFSAAGRGLTLDRVYVELSALVTELAPAVGGDLANIRINPLHTAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD92</accession>
    <name>A0A231HD92_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46687">
        <property type="protein sequence ID" value="OXR46687"/>
        <property type="gene ID" value="B7C42_01662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="140" mass="14766" checksum="FCF65C3E56889B4C" modified="2017-10-25" version="1">MTTVLIVRDVLAADGSRMPTQGRFIDSADLAKYQAYGWRLPLGAPAIPVPASTLDGFTKSPTDIDSWQWDWSPYLMAGETVTASQFFTVPGLTLSSPTLVGATTKVLCAGGTSGTTYVVTNRVATSAGRQGDALFTVTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDK2</accession>
    <name>A0A231HDK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_01823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036497351.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46845">
        <property type="protein sequence ID" value="OXR46845"/>
        <property type="gene ID" value="B7C42_01823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041642">
        <property type="entry name" value="KstR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17925">
        <property type="entry name" value="TetR_C_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR46845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="19958" checksum="D324A63D6FFE6348" modified="2017-10-25" version="1">MEATRRRLTEKQADTVDRLTKAALEVLSREGFAGLTVRMVAAAAGVGTATAYTYFSSKEHLVAEVFWRRLAADAPPEPEAGADRTTRVVAVLRQIAMLVADEPALAGAVTSALLGTDPDVAHLRTRIGTEIRRRLLDALGPDADPDVVETLELLYAGALVRAGVGYASYAEIADRLEKSALQVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDM6</accession>
    <name>A0A231HDM6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_00149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47030">
        <property type="protein sequence ID" value="OXR47030"/>
        <property type="gene ID" value="B7C42_00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="604"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="1157" mass="124022" checksum="B88DE5DF1445E125" modified="2017-10-25" version="1">MTAATPVLSGVQTLVRLLALRHELDLRDGTTTATMVSGYPGSPLGGFDLELEQHDPQRHRIVHRPGLNEELAAATVWGSQMGAALAYDGVDGVVGAWYGKGPGLDRSGDVLKHANAMGAGPSGGAVVFCGDDPAAKSSTLACDSQYTFADAGMPVLFPGDQQDVLDLGMHAFRMSRYAGCWVGLKIVTAVADGIGTVDPDLGRHHPAEPRVSIGGRIWTHRPQATIGPHAVPGQEELINEHRLRAARAYARHNGLDRTVGPDTAELGIVCAGATYFDVVQALSERGVRRADLAAAGVRILRLGMTYPLVEETVVEFADSVRRLLVVEEKRPFVETQLRAVLHEAERRIPVLGKRDRDRAPLVPGSGVLDPKSVGEILDRVLPALRPATPPRLELPLLVTPARAPAYCSGCPHNRSTVAPEDALVGGGVGCHGIMYFEARNRDLTTLPPTPMGAEGVPWIGLSPFVEAPHLIQNLGDGTLTHSGTLAIRASVAAGTDITFKILYNAAVAMTGGQEVTGLRDVPALTRQLQAEGVREIVVCAEDPGRYGRRARWAPGVEVLGRDRLAQVQQRLRTVSGVTVIIYDQRCAAEARRLRKRGLLPEPPRRVVINEAVCEGCGDCGTKSNCLSVLPLDTEFGTKRRIHDSSCNRDYTCLDGDCPSFVTIEPKAGARQRNRVRRARPRLPSGTLPEPAPPAVGERYSIYFTGIGGTGIVTANRILVRAAEAAGWVVGGMDQTGLSQKAGAVVSHLHLAADRAGLTAAAVSGGGADLYLSGDILQAASADHLAKARAGQAIAVVDRNVTPTAAMLQSHTAAPDVAALEAAIADRIGAQRTSVIDARRVAERVFADHLPANVVVLGAAFQLGGVPVSAADMAGALAGRGRAAADNRLAFEWGRWLVHDPTAVAAALGDERVASTARGYEPTVAAGAAAERLVAQRFVPVELRDRLVRRTAQVIDYQSVGRARRYLELVEYVAARDDAAREWELSRTVAESWFALLTYKDEYEVARLHLAADYDAVAAELGLDGGYTLTYHLHPPILRRLGMARKLPAGRTYALAFRVLRRMKRLRGTPFDPFGWDRDRRTERAVIVEYARLVTEITDPGADLPYDRQVELAASAAAITGYGPIKERSIERWRAGIAAWRLEHTSAEPMSEASGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDT5</accession>
    <name>A0A231HDT5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47091">
        <property type="protein sequence ID" value="OXR47091"/>
        <property type="gene ID" value="B7C42_00213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="137" mass="15219" checksum="A485D091FF3A0C3C" modified="2017-10-25" version="1">MREKFQNAQPNSGEAIPYAEANHDREQRLAWDVSEALLQAVYDAAERTGEDARSVAVTVALQQVERTHAFDVSNEDDQHVLAAQANYVADRLIELIDAYDELTTSDLQGAIEALALRLVHHQLPVGRVEQTEGGDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HDX2</accession>
    <name>A0A231HDX2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded DNA-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ssb2</name>
        <name evidence="4" type="ORF">B7C42_00179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47059">
        <property type="protein sequence ID" value="OXR47059"/>
        <property type="gene ID" value="B7C42_00179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="169" mass="17765" checksum="BCEB4B483E99185D" modified="2017-10-25" version="1">MYEANTAVIGTVVTHPARRSLPGGEQVVSFRMASNARRFDRDTGGWVDGGTLFLTVTCWRRLVEGVDASIRRGDPIIAYGQLRTNEYRTREGVQRHDLEMRAAALGPDLGRCTAPVMRRGGARNSGPDLHVVPGGDDAVPEAPPGESGPAAGVVSTTVDPVSAAAADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE96</accession>
    <name>A0A231HE96_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_1</name>
        <name evidence="5" type="ORF">B7C42_00425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47303">
        <property type="protein sequence ID" value="OXR47303"/>
        <property type="gene ID" value="B7C42_00425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="311" mass="32278" checksum="8004C2564542D7C7" modified="2017-10-25" version="1">MTSALTSGSAERVAAAPVIELRGLTKTFRSSGGPVRAVDGLDLTVTAGEVVAFLGPNGAGKSTSIDMMLGLLRPDAGTARILGGTPAEAVAAGRVSAVLQSGGLLPDLTVGETVRVVASLHRNPRPAREVLVRAGIDGIADRMVGKCSGGQQQRLRFALALLPDPDLLILDEPTTGMDVEGRRDFWNAIRADAGLGRTVVFATHYLDEADAYADRIVLVRGGRVVADGSAASVKNLASGRTVSATLPDADPASLLALAGVDRVEQRGDRVLVHGNDSDAVARYLLTRTPAVDIEITGRNLEDAFLALTGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEC8</accession>
    <name>A0A231HEC8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47128">
        <property type="protein sequence ID" value="OXR47128"/>
        <property type="gene ID" value="B7C42_00250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="421" mass="45916" checksum="34EC1EED5441BD58" modified="2017-10-25" version="1">MASPEALPARGAVFWPVGTGDSTTLVVDESTVLQIDLHDLAKAQDEENPEVAVVDRLVDALPTQDGKPYLATFALTHADKDHCLGFADLLSKVQIGELWSTPRLWREFNDPDAPEPCPDAVAFREESERRIEATMAAIAKGGQPASGDRIKVVGYDDEHSKQAYDELPDEYKSWPGKSITKLDGRDYSDRFEAFIHAPFREDCAAPRNETSLAMQVTLTDDTGTTGKLLLFGDLAHDTIMKIFEYSEHHDRANYLEWDLLLAPHHCSKKVMYKPNDSGNDELQLDIMDAFERHRLESGVVIFSSGIVPSSDTPGANPPHRKAADRYAEISDETICTMSWGDEKAPSPIILGIDATGARIVREIDISAASRLAAVTAAATSLASALPSLAPETEDTTDPIEDAVISDRGGERAPDQAVGFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEF2</accession>
    <name>A0A231HEF2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036508828.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47321">
        <property type="protein sequence ID" value="OXR47321"/>
        <property type="gene ID" value="B7C42_00444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="81" mass="9034" checksum="4466E633E520DD4E" modified="2017-10-25" version="1">MGKEQETGQFTGTLDKDYNLVWFTEQCMSNALRMEVYSRDAERAGDAELADFFRRAQADSRKGADMGKELLAQRLAGAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEM4</accession>
    <name>A0A231HEM4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DegU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degU_1</name>
        <name evidence="5" type="ORF">B7C42_00513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47390">
        <property type="protein sequence ID" value="OXR47390"/>
        <property type="gene ID" value="B7C42_00513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="234" mass="25193" checksum="B48B74FF78BAA716" modified="2017-10-25" version="1">MNPGQTPLTETDTATTTVLVVDDQELVRGGLRRILRRRDGFVVTECGDGDEVPAALTEHRPDVVLMDLRMKRVGGIDATRRLRTRPDAPPVLVLTTFDDDHLLSGALRAGAAGFILKDSPAEDLIRAVRTVAEGGSWLDPSVTGRVLSAYRTARPVPADTRSRMAELTARELEVLKLIGRGRVNSEIAGELGISEVTVKSHVGHIFGKLGLRDRAAAIVFAFDHGVVAPGESAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEN2</accession>
    <name>A0A231HEN2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cold shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cspA_1</name>
        <name evidence="3" type="ORF">B7C42_00564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47441">
        <property type="protein sequence ID" value="OXR47441"/>
        <property type="gene ID" value="B7C42_00564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="8530" checksum="C343FC12C96DD4F6" modified="2017-10-25" version="1">MKWFDSEKGFGFIIPDGGGPDVFVEYTEVHGDGFRRLVQGQRVEFDVRHTKAGPEAEGVRIEPMRRLWPDTHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEU5</accession>
    <name>A0A231HEU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease YtrF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ytrF_1</name>
        <name evidence="9" type="ORF">B7C42_00517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47394">
        <property type="protein sequence ID" value="OXR47394"/>
        <property type="gene ID" value="B7C42_00517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="745"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="280"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="474"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="730"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="830" mass="84841" checksum="D458A95EB8378225" modified="2017-10-25" version="1">MITAGWDRLRLFNIGELFTHKGRTAMSMAVMGVSAGLLVAVLSISGSVTGSVDRLTSALGGKAQLEISGVTESGFGQDLVPQVRAVPGVEAAVPMIRTGVGNPADRTLLIGADASVSALGSDLNGAMSAQAAKLLSVPGGVLVGAGLGRHEGDTFTLGNRQVTVAGVLDDATSHKLNSGHIVIATLPVAQQLAGRAGMLDSIQIVPKPGTDVGQLRSALTTLVNGRAVVADPSLRTAQASGAIQLVRFSTTMASAAALIVSGFLIYNAMSMAVAQRRPTLSLLRAIGGRRRPMVRDLIVEAAVIGLIGGAIGSVVGIFAGRMSIDTIPSAMVAAVDTRTEYMVPGYAIPFAIAACVLASVAAAAIAARQVYKVQPIEALAPVGVSKADAVGPWLRWGALVGGLAMVGGAIVIARADLGRASLAAISLSIAGTVALCFAAMGPIVRLAAAVARIFGAPGALGATTIERAPRRVWATAMTVMIGVTATVAMGGASSNLVDSATDSFSDLGRRDAYISPTSLAEFPTGPLLPADLKEAVRRVPGVADVGSAQMAFATVGSDRVMLQAYQSNIRSSVLADLGPDVLQQMSSGEGVVLSRDVARSLGVGAGAQLELPTPTGIHSVRVLRVIPYFSALSGIVLMDLDVLRQWYDRPGETILGVNFAPDADKAQVIDAIRAVVPPGLHVDTGAEALAAVSQGVQQGTSLSGSILWIVVLVSTAALLNTLMLSVLERRRELGVLRAMGTSRRFLLRTVLTEAAGIGLAGAALGLVTGAAVQYLATMAMGHAMTIDVVYHPSPMLLVYAVAALVLALLGSIPPSLRAARMPIVEAIAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEW6</accession>
    <name>A0A231HEW6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781663.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47414">
        <property type="protein sequence ID" value="OXR47414"/>
        <property type="gene ID" value="B7C42_00537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="256" mass="26401" checksum="C583ECED8338968D" modified="2017-10-25" version="1">MDRSSFRKLFDLSGRTAIVTGGTRGIGLALAEGMACAGANVVVASRKPEACEKAAERLRELGAEAIGVPTHLGEIDQLQGLVAKTVETFDGVDIVINNAANALAQPLEVMQKAAVDKSFAVNVQGPLFLVQAALPYLRASKHAAVLNFASIGAFGFSGGLAMYSAGKAALLSFTRSMAAEFAGDGIRVNAIAPGAVDTDMVRNNPQEVVDAMAAAPLLRRLGEPDELVGPALLLCSDAGSFITGQTFVIDGGTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF00</accession>
    <name>A0A231HF00_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47442">
        <property type="protein sequence ID" value="OXR47442"/>
        <property type="gene ID" value="B7C42_00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="38" mass="3821" checksum="3EF1739ACE7789CB" modified="2017-10-25" version="1">MIPVIIDTGSAAVNGLFDTLGAAFHGLVNTLWTGSFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF39</accession>
    <name>A0A231HF39_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779770.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47560">
        <property type="protein sequence ID" value="OXR47560"/>
        <property type="gene ID" value="B7C42_00685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="216" mass="24447" checksum="3B40352512E83335" modified="2017-10-25" version="1">MVTRLNLTTDELLTTTRAVRKRLDLTRPVEREVLEECLHLATQAPTGRNRQRWAFVVVTDPEKRAALANLYRKGLMAPTEAVPEDGIDWRDDPAQIQRGHDSGHHLFRYLHQVPVLLVPCVHIVRRTRPGAVDLANSFGSILPATWSFMLAARERGLGTVWTTPHLQYEREAAELLGIPYESVLQTALIPVAYTIGTSFRPAARTDLDNVAHWDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HF85</accession>
    <name>A0A231HF85_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_00669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47544">
        <property type="protein sequence ID" value="OXR47544"/>
        <property type="gene ID" value="B7C42_00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="7">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12602" checksum="C7ECA5F79BC362FA" modified="2017-10-25" version="1">MTSDAVPSQGPDPVPHTDPPRVDTPPSTAPARRNRALKTRAGYTWVALVAAAVIGVLLLIFILQNLDQVRIHLFFWQFNLPLGVTLLLSVIAGALVMALAGGWRIMQLRRAAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFU3</accession>
    <name>A0A231HFU3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator KdgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdgR_2</name>
        <name evidence="5" type="ORF">B7C42_00978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47853">
        <property type="protein sequence ID" value="OXR47853"/>
        <property type="gene ID" value="B7C42_00978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="63"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR47853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="271" mass="29404" checksum="F3642EDB3AF8FBCA" modified="2017-10-25" version="1">MSSVLGKARLILDAFDTECSDLSLTELARRSGVAKASVHRLAGELVEWGLLERAGTKYRLGLRLFELGQLVPRQRILRDAALPYMEDLLLATQETVHFSVRDGIDVLYIEKIIGHRGLNQQSRVAGRLPLYCTATGKMILAFSPQSVFDAVVEQGFTALTRRTTMSVAVLRTQLERMRKEQLAVEVEETRLGYMSVAVPVFSGPGVLAGALSVTGPTARLNVSRITGALRTAGVGITRTLQAMRCTHTPGEPSRPTGACSPAMCSFNGCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFW5</accession>
    <name>A0A231HFW5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC_dehydrat_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779652.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47840">
        <property type="protein sequence ID" value="OXR47840"/>
        <property type="gene ID" value="B7C42_00965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="161" mass="17644" checksum="5F3D32106B299663" modified="2017-10-25" version="1">MRPDLRTAEARARALVGTAEHRALGQLRAAETVAFAHACGERDPRLLDPDTDGFRVHPLYLPSLLRGPDGGVDADYREDGMFRDEVPGTDGLAVNLMAGGQSIAFHREVPLGDPIELRRTLDAVDRKGRPGKEFLLLTVSKVYRAARAGDLATVTERFIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFY1</accession>
    <name>A0A231HFY1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xanthine dehydrogenase subunit A</fullName>
            <ecNumber evidence="3">1.17.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pucA_2</name>
        <name evidence="3" type="ORF">B7C42_00917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782844.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47792">
        <property type="protein sequence ID" value="OXR47792"/>
        <property type="gene ID" value="B7C42_00917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="199"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="371" mass="39020" checksum="725D20A147966742" modified="2017-10-25" version="1">MRDVLAALTSVWRSGGTAGVATVVRTRGSAPRPVGAAMVVAPDGTVAGSVSGGCVDAAVYELAAEVARTGRPRLHSYGVDTDELFGTVLTCGGEIDIFAEPISRTTCPHLPVMIAAVAADRPVATATVVANSDCARPGRRLIITPDTVHGSLGSARADAAVTERARELLAADHAELIGCAPLEAGTDVFVNTFASRPRLLIFGAIDFAAALAQQGALLGYRVTVCDARPRFATADRFPAADEVVVDWPDRYLTAQAQRNTLDGRTVVCVLTHDPKFDVPLLRVALRLPALGYVGAMGSRRTHDDRLRRLRVAGVTDTELCRLASPLGLDLGARTPQETAVSIVAEIIMRTHGGAGHPLTELGGRIHHDHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG00</accession>
    <name>A0A231HG00_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative siderophore biosynthesis protein SbnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sbnA_1</name>
        <name evidence="4" type="ORF">B7C42_00894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47769">
        <property type="protein sequence ID" value="OXR47769"/>
        <property type="gene ID" value="B7C42_00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="25"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="369" mass="39429" checksum="4E3A59408566ED90" modified="2017-10-25" version="1">MDDIVLDHPQPIPAAPIPAHRPRGLVGNTPVLWIGEPLSGRGRGFWAKLEGANPGGMKDRPALHMVRSAEIRGDLRPGARIVESSSGTLGLGLALAGMVYSHPVTVVTDPGMEPMVVRLLRAYGARVETVTEPHPTGGWQQARRDRVAALLATEPDAWSPDQYSNPDNVDGYESLALELVQQLGRVDVLVCAVGTGGHSAGVARVLRRNNPRLRLIGVDTVSSTIFGQPAGPRLMRGLGSSIHPRNVDYDAFDEIHWVAPAEAVWACRTLAATHHASGGWSVGAVALVAGWAARVHDTGARIAAVFPDGPHRYADTVYNDAYCDEHGLLDADPPVEPDTIGHPAERVVTSWTRCTTVVDPRTLDPEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HG17</accession>
    <name>A0A231HG17_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YbjI</fullName>
            <ecNumber evidence="2">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybjI</name>
        <name evidence="2" type="ORF">B7C42_00914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47789">
        <property type="protein sequence ID" value="OXR47789"/>
        <property type="gene ID" value="B7C42_00914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="36233" checksum="5FD408A57551BA96" modified="2017-10-25" version="1">MNAPDDSRRRTYWSRHGRGDDDRTRGVVHDESGWVRSGSASDELSEDDGHLGGSTDPAPPPWSSIPPGDHGVRLVVCDMDGTLLTKAGAVPDTFWPLLEVMRSRGVTFVPASGRQYATLAALFERAADEVSYIAENGCLVVHSGVTVSATCLDVDIVRQVVQAVREAPAATELGLVVCGLDSAYIERTDPAFVAEAAKYYARLERVDDLTAVTDKVLKLAIYDFTDAERTAAHVFGSIAAREQVVVSGEHWIDIMSRDADKGRAVRSLQQTLGIPPARTAVFGDYLNDLEMLDAARWSFAMANAHPEVRARARYLAPADDEDGVVTVLSRLFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSR8</accession>
    <name>A0A231GSR8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase PknD</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pknD_4</name>
        <name evidence="2" type="ORF">B7C42_08262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000094">
        <property type="protein sequence ID" value="OXR39669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39669">
        <property type="protein sequence ID" value="OXR39669"/>
        <property type="gene ID" value="B7C42_08262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="789" mass="84264" checksum="7C8C06724D178368" modified="2017-10-25" version="1">MLVVAVTLAAAWPTQRFASTRWDESVEWAVRLGLLAAVVIGFFGPVERERLGFRSQAERFTMVMVLGFAAAFAAGGLSYWAWADMSYRSAIVETAVGNAQYVAESFLLIALVVGFLRAPMGSSPTAALRESPRVADTAAGRFRAHIGPIAGTAAVVGVVFGLIFAIGVFTEHVVLKHESVRDAVLVALREWLTVGPIVGICSALAVQLGRRILRPGFEAAAERATMRQPRIFAAVTVTMVGTLAGSALLPLVRDMLGSGEAGWGPVVRAVKSSVQLALGPAIILGFLPWEPRPMSLQLRLRGRLVRLLTVSAIAGAAGAATLWFAADLPDAGQKARDCLLVGLPFGLAVGILAVALDRPVTLDRPIGPLESLRLDRRAAAIYSLAYAVAAGAATWLHAAISPTTTLGAQDIGLFAVAFFVISYFLTASGRHTITSVWMWLAGRMPLRDMEFYCTAHRRGVLRQVGSVYQFRHALLQDRLATGGRRPFPHSRTHAVLVLVAAAVLVLSSVAALAHHAYERRESLARSNAATLPFDDVSFPLGVAADHAGTLYVAGTTFEKSGDIVEKDATLGRLWRWKTDAPTPSMLEITDLGIAFTLAVDRANNLYIADSDKHHVLAVSPRSVVPVTLPFPELVKPIGLDVSESDDVYVSDNGTGTVWKLSAGSTTATALPFPKLDHVTGVAIDSAGTVYANEAGRNRVLKLTIGSTVPTALPFDGLDKPSGIAVDSEDTLYVCDWSGRVMKLRAGSATPEVVHMTGLNRPQSIAVDDAHNLYVTNPYDNRVLKLPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GST8</accession>
    <name>A0A231GST8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000085">
        <property type="protein sequence ID" value="OXR39689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781993.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000085.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39689">
        <property type="protein sequence ID" value="OXR39689"/>
        <property type="gene ID" value="B7C42_08235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="180" mass="20966" checksum="AC22AFBDAA1EC331" modified="2017-10-25" version="1">MSWSDVIKAVPPFALGALLIALYNLYLKHREMTIHGWHVVTERSHTVTNGWRDAAVTFRVMGPHTMYEINVHGWGDIEIPEDYAGEIPKMTSESDPIRLELTYRYDPDEDGPWVGVVWTEASRLGVVEHGARINLLTSDYERWQWHHVRNFFRPWRKPTGGWHPAAEMRARRTYQVPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSU6</accession>
    <name>A0A231GSU6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_08228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000083">
        <property type="protein sequence ID" value="OXR39704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39704">
        <property type="protein sequence ID" value="OXR39704"/>
        <property type="gene ID" value="B7C42_08228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="476" mass="53195" checksum="0DA24EC2FCD41075" modified="2017-10-25" version="1">MAGEPPWVDRRGIIRTSNSVHVSPLPDVIRAYMRAHGLTKHEEMARVLGVDRTLVSKYLTGARDCRDVLQLRHFAQAMDLPPETFGLMELPQSIPVDSADTVADWRFVRRTLNRNRHELTATAARLYWDSVPIEGTTCITRPNWMAPVPLDLDSIRLEFDDDAPPPMCDGTEVESEPYRPMRPNGLSRYTRYSQAVRAIARPTLFENRASYRLLDVSFDECGGRMAFGSTTYFDMVDVCEVIAHETAAVWTAHRGASRITMEDLPFRNRVGDLFDPGRRPILPSINTLTIRRAPEGDTFFLHRRGSNSVTLAAGLTHIIPAGVFQPAAIGQVNMSRDFSLWRNIIREFSEEFLDTPEHDGSSGTPVDYDIEPLRTLTDARAAGKVRAWCFGVGLDPLAPAGEILTAVIIDSDVFDSAFEELVSRNSEGEMYPSEDGTLGIRWTSKNVRRVLNREPLAAAAAACVALTWRHRATLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSY1</accession>
    <name>A0A231GSY1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_08195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000076">
        <property type="protein sequence ID" value="OXR39734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39734">
        <property type="protein sequence ID" value="OXR39734"/>
        <property type="gene ID" value="B7C42_08195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR39734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="27403" checksum="EB1EC8B20109A94F" modified="2017-10-25" version="1">MSWTHVLTTHEFWAGFPSGALVSGIVTPIITARAVRASDRRKFAQEDRVLDRKEARENKIRDEESLYNVAMEYVSVCNEILMNSVDIKGAFNAFRDMVFNRAGAPDPKADDKIDHASKVAEENKRIVQPYNRLRMVAPKNVIDAAVKLNAAMLAVLRATTEPLAQPVTRKAAADEMENFINVFRAEVGKEQYTASEAHEKTISFLANLKRQVNDYVEESREEMRAAGFPSTPWDDMEENPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSZ2</accession>
    <name>A0A231GSZ2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000075">
        <property type="protein sequence ID" value="OXR39737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39737">
        <property type="protein sequence ID" value="OXR39737"/>
        <property type="gene ID" value="B7C42_08187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="31308" checksum="13413713C307D56D" modified="2017-10-25" version="1">MASDPSKVQQSGHKSETAWVNALAGWLPPQYQIGQRKYLLLEDDSAGRAISAETDIVIFQPSYPERLRNREEILVSGVAAAFSVKLTLDRAGISEAIQQAAMVRRGTKIRSYSVTDEVLPPLFYGILAHSHRWKQPGSNPTENITRALVELDQEHSKHPREGLDLVCVADLDCWSRVTTVSTFPEPGTPRAVIDPYGGVRSGFFVEGEPRPTGPPVATLISLLLNKLSYRDPTVKPIADGLRLTSSGGDGDGDLRHWYLPEALSRQAQEQLRGQPWGWEPVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTG3</accession>
    <name>A0A231GTG3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mycofactocin radical SAM maturase MftC</fullName>
            <ecNumber evidence="8">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mftC_2</name>
        <name evidence="8" type="ORF">B7C42_08086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="NGAF01000058">
        <property type="protein sequence ID" value="OXR39845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39845">
        <property type="protein sequence ID" value="OXR39845"/>
        <property type="gene ID" value="B7C42_08086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="40"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR39845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="381" mass="42588" checksum="FDD8DAA71498C1DD" modified="2017-10-25" version="1">MTSTDLPMPSPKPNSNGYGHARMPRGANVPEPQKIDRVPYGRFRNIYLYITEACQLRCEHCYMGERLDRALKMPLPKIVDTLTTWRRLGGSKLTILGGEPTLHPHYCEAIRLSKKLGYEHVITTTNAQKPALRRFRQLAPDDFAYVQVSLDGGSQATHDGVRGAGTFDEAMETTRELAERGFDVRIICTVNKANERDVVQLLDIADVVGVSLVKFHVFSTIGTGHGNPEMAMTPPEWVDFCDQLNTVAPQYNTRVWYQPTYARRDQMERYAAEGYQGCIGRTLDRISIFPDGRCYVCSYLFDTDLYFAQMTDGQVQLNHGVNEFDLFTSVLNESSCGGCKSSGCMGGCPAEEVVMGKSSCAAYEDIVPVCRLWKSSAKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU09</accession>
    <name>A0A231GU09_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monoterpene epsilon-lactone hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlhB_4</name>
        <name evidence="2" type="ORF">B7C42_07812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.83" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000041">
        <property type="protein sequence ID" value="OXR40104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40104">
        <property type="protein sequence ID" value="OXR40104"/>
        <property type="gene ID" value="B7C42_07812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="70"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="313" mass="33503" checksum="A6C988F841AE641F" modified="2017-10-25" version="1">MPSEAFNAVADWLRQNLRSSESDLVAEREAMAQYAAAYRPLFGVADEPAPVGQPGSYVMTPTACRDDVVVLHIHGGGFRSGNAGLLRLVSAQLAADTRARIVLPEYRLAPENPFPAAIDDCMEMFDYAATLAPRIVVAGHSAGANLALAVLLRTVGDERAAGGVLFSGVYDLRPERFERGSWVERASSELVLTHEGGLSMHHDYLAGRSATDPLVSPLLADLTGLPPLFLQAAGKERLLDDSLMLATAAAQAGVHVELEIWPDMFHDWTAAATMPEATEALSRAASFIDRVASGRIGKPALSDGVTLQHRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUR1</accession>
    <name>A0A231GUR1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40369">
        <property type="protein sequence ID" value="OXR40369"/>
        <property type="gene ID" value="B7C42_07535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="118" mass="12610" checksum="7C635C3B87B1B7CA" modified="2017-10-25" version="1">MPTWQFLRNALLRSRDFDVSAAILPTRGRSGGWGKIGFDVVADLLFVAGAVNGGNDEGAQPFSEVGVIDADHGGVQDLGVIGELNALAIAFEGRITPSGNQPYRVRFTGDPALAHFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUS6</accession>
    <name>A0A231GUS6_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_07522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40356">
        <property type="protein sequence ID" value="OXR40356"/>
        <property type="gene ID" value="B7C42_07522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR40356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="227" mass="23697" checksum="748E80ED1687B0A0" modified="2017-10-25" version="1">MRHAVARIWARRPTRPLEEYSALRIGLAAVVVLAAVVGGTVFVNSRHLGRETYRADFAQAAGVGAGDGVTLAGIEVGTVTGTRLAGDHVVVTMKLRRGLPLGADTGAAIKLTTLLGSRYVELRPAGPGHLAGNAIALAHTEVPYDLETALQNATTTFSGIDADRIAQAMSALTDQLRGTPVVVPETLHNINTLASVIGNRRPSSGSFSPVPTRSPRCCVTSSGSWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUT5</accession>
    <name>A0A231GUT5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_07603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40342">
        <property type="protein sequence ID" value="OXR40342"/>
        <property type="gene ID" value="B7C42_07603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR40342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="29501" checksum="E82DBDC4C2640D84" modified="2017-10-25" version="1">MDYALAHHYLEGAELAARSGDRDTLSWYRTHSRTFPPHWFTTTPIGPTIVQCPDPRTLRQSPIADTPYHLLGPNTEPAPPLATELVAAAFDIGAEYGFGDLIADHAPIVCLLIERKLGEPLNSWAITRLPGTVFLDHVGDPTILARDLIHEAAHNWLNTALAAADVELDDGKTWNSPWKNTRRPTFGFLHSCWAFPLTMLFAARAVRRVPQVLATYLAQHRRKLASTAADHQHALAAVTDTDLRERLRTVHALALRACPDQPPLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GUV3</accession>
    <name>A0A231GUV3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB</fullName>
            <ecNumber evidence="2">3.5.1.110</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rutB_2</name>
        <name evidence="2" type="ORF">B7C42_07573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.110" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000033">
        <property type="protein sequence ID" value="OXR40407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782155.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40407">
        <property type="protein sequence ID" value="OXR40407"/>
        <property type="gene ID" value="B7C42_07573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="212" mass="23182" checksum="C62D22272111E7C2" modified="2017-10-25" version="1">MQYDTNRTALIVVDPYNEMLAEGGKVWPRLREVAERVGTREHLEQLLTAARAAGMPVMYAPHRRWRPGDGAGWQHTPRPHSAVVQAHLFAEGSFGGQWYAPTAPGHSDVVAYEHWGMSGFANTDLDLQLRMRGIERVIIAGMTAPGCVEGTARHAMELGYPVTLVTDATAAYSDELMHAAHHLNGPLFAEHILTTEEVITVLATTPTAADAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV14</accession>
    <name>A0A231GV14_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Baeyer-Villiger monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000034">
        <property type="protein sequence ID" value="OXR40321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40321">
        <property type="protein sequence ID" value="OXR40321"/>
        <property type="gene ID" value="B7C42_07582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="487" mass="53465" checksum="CA26298CB764D596" modified="2017-10-25" version="1">MAAELRSSGIDNFVVLEGGEDVGGVWRENTYPGCACDVPSHLYSFAFDPYRGTDIRFPGQADILDYMRQVADRHGLRTHLQCGTTVLGADFDSATSTWTLTTTAGQKIRARSVVWAVGQLHRPAYPTLPGAHSFRGRAFHSARWDHEADLTGHIAVIGTGSSAAQMIPELARTAASVTVYQRSSAWILPKPGKRFGPVSRWVLGRVPGAHQLYRAGLYHGADAVLAPIMRGGWSARPATWIAHAHLRRQVPDPALRQALTPRYRIGEKRILLDNMFYPTLMRPNVELVTDRIDRIVADGIYSADSTHRRADVIVYATGYRATELLGGIRIRGRGGVDLHDRWNSARPEAFLGLAVPGFPNMYLIAGPNSFTAANSNPSLKADQARYIARCIALSDRWDAPIEVTTAAMSQYRVWLDAQLARTVWPTGVRAWFKRPSGEVTNAWPTTARAFRQMTRTDAARAFYPVPGTSAASAATSSSKTTTAHTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GV83</accession>
    <name>A0A231GV83_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_07356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40547">
        <property type="protein sequence ID" value="OXR40547"/>
        <property type="gene ID" value="B7C42_07356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="121" mass="12722" checksum="0211AD5CCBA1B6B5" modified="2017-10-25" version="1">MEIAYWIVGSLLAVFYLYSGGIKILRSKDQLRPMMGWIDTVPLGLVRGIGVSEVLGAAGLILPPLTGIAVVLALLAAVGLALVQVGALALHLRRGEVKLIGLNAVLLVLAVVAAWLSTVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVL8</accession>
    <name>A0A231GVL8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000028">
        <property type="protein sequence ID" value="OXR40663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40663">
        <property type="protein sequence ID" value="OXR40663"/>
        <property type="gene ID" value="B7C42_07221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="35007" checksum="5B570834656606AE" modified="2017-10-25" version="1">MRGRDAARPVGPRVAAAGAPWRMRRRDEEPNQSAALPNSLHAGLDVRFTSVAGVWHGLLPGLFLRWAGRPASERQGSSVRSALRKGRDSGIGADPSTSNAVAGRFSTAMAAKRSCAQWPAGTTTGLSPSRSVASGGAGGGHRVRPRRSGISRTRRSGSASKAGAAPISLLPLHRSLLDQGCGPNGCGGNWNGAPSSIHTASTSSSATTWTGIVIHMSPCRTSRRCTVDPTANLGMVATLTRSTMLFGDLLPAAFRHTLSKAMCPKPRRARACGNGVTREGFSLGADGRDGRADGCRADRPCRSDTSTALPDGCRWVSNLADGDAVHSTREPRGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVN0</accession>
    <name>A0A231GVN0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase-like protein YjlD</fullName>
            <ecNumber evidence="3">1.6.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjlD_3</name>
        <name evidence="3" type="ORF">B7C42_07340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40531">
        <property type="protein sequence ID" value="OXR40531"/>
        <property type="gene ID" value="B7C42_07340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="42084" checksum="FA31ECBCA0FAEFB7" modified="2017-10-25" version="1">MKHRIVVLGAGYAGAFSAGYLARQLHPDDFEITVVNAEPDFVERLRLHQLAAGQELRHRPLDEVFADTGVRLRVARVTAVDVEERTVTVADGDAIDRLGYDTLVYALGSTAADQGVPGVHEHAFHVAARPSALRLRTRLDELGEDGKVLVVGGNLTAIEAATEFAESRPGLRVGLVTSGQLGGWLGAKARRHLLRAFERFDISVHEHTTIGRVEKDAAVATDGTVFTSDATVWAAGFAVHPIAAASGLEVIANGQITVDRQMRSVSHPDVYVAGDSVFVIGENGRPLPMSCASAGFTAMQATAAIIGDRTGRKIATTSLSYVGNHISLGRKDGIFQLVGGDAHAKSWALCGRTAARVKSTILDTAAWSLSHPTFGKPSHKYRAAAALEHSPRVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVZ3</accession>
    <name>A0A231GVZ3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_07336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000029">
        <property type="protein sequence ID" value="OXR40651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064908885.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000029.1"/>
    </dbReference>
    <dbReference type="REBASE" id="234280">
        <property type="entry name" value="M.Nce30759ORF7336P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40651">
        <property type="protein sequence ID" value="OXR40651"/>
        <property type="gene ID" value="B7C42_07336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="165"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="524" mass="58274" checksum="24AEAFDFFEDDC834" modified="2017-10-25" version="1">MAVTQQEIENRLWDAADELRVAMPEAQYSSVVFPLMFWKYLSDTWEHHHQEFLEENRGLEDLSDGEAREIEYRDYQSFEIPNIHPGTVHERRASWSSILATITQPGLGQRVRASLQAIETANPDKFSRLFGSMTWTSEEVLRSEVLAAVMRAMDRVPKMHEGNMSHDVLGGAYEYLLKRFSDGSGTRAGQFFTPREVVELLVELLDPKGFESVYDPTCGSGGMLIASANLLKAHGGRGYTLRLYGQESVLDTAGVARMNLFMHNLTQFQIEVGDTLKEPRFKMPDGSVAQFDVILANPPYSLKWKPWNKDPRAIGGVAPQSTADWAFVQHMIASMHPTKGRAGVVLPHGVLFRGGQEAAIRQRVLDDDLLEAVIGLPANLFYSTSIPTAILLFRAHGSKAMERKDGVLFVDASKRITKAKNRNVLTQTDIADVVATYHSNFDSDVDSVCTSGNGTLPARFVPTTEIAANEYDLNIGRYIKQTTAEAEDLGTLIDAYNIARAERQKAEQRMLAVLAAAAIEGFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWB0</accession>
    <name>A0A231GWB0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_07195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40771">
        <property type="protein sequence ID" value="OXR40771"/>
        <property type="gene ID" value="B7C42_07195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="177" mass="18954" checksum="24A66FE71A82C581" modified="2017-10-25" version="1">MPGVTDRIRPPYVVVMGVSGTGKSTVGRLLADRLGIPFADADDLHSPANIAKMSAGIALTDEDRAPWLAAVGRWLHDRMGEETGGVIACSALKRSYRDTLRTAAPGVFFVHLTADREELLARVTGRRGHYMPVALVDSQLQTLEPLDAAERGAVLRTDRAPEVLAAHAAALLAPNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWD6</accession>
    <name>A0A231GWD6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nickel-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nikA_2</name>
        <name evidence="3" type="ORF">B7C42_07020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40885">
        <property type="protein sequence ID" value="OXR40885"/>
        <property type="gene ID" value="B7C42_07020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012014210" evidence="1">
        <location>
            <begin position="30"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="88"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="520" mass="56075" checksum="09944CFD1EF39BE9" modified="2017-10-25" version="1">MKYSVSGGRKLLAVLAVGAAVLTGGCSSALGGDSGSGGALNSDRTLTLALSRQFTGLNPHNGGSPDSDGSVKGTVYEALTTLDPSGGVHPRLATSWTSPSPLEWRFTLRQGVHFSDGTPLTAQEVAWNFAELLDPATKSQLGAQFKIYADSVTAEGADTVVFHLKQPAIDLPSRLWNFYLTTQKFWETGNLNTQALGTGPYVLKSIDLENGAQIEANPEYWGTRPAFPHVKYRVLPSEAARVSAVQAGEVDIALNLDPLSLDQFAGNKDYRSTLSDSSWVQVISINSNKGGPLADIRVRQALNYAIDKKSIISGLLKGAVQPSQGQIIAPPFFQPNPAITAYDYNPDKARALLAEARHANDVVLNLDIPAGTYAAGTAIGQAVVQQAAAVGIKINITETPFPAWLARQNQPSDQAADLVYIGWGAYYKDAWTVFDPFTSKSRYKQSNITDTVFDDLVNRLQAATDPGTARDLANQATQRYHDQAHTVFLWPGTFTSLVRNGLTWAPRTTRYLYAQEVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWF9</accession>
    <name>A0A231GWF9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heterocyst differentiation ATP-binding protein HepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hepA</name>
        <name evidence="10" type="ORF">B7C42_07040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783808.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40905">
        <property type="protein sequence ID" value="OXR40905"/>
        <property type="gene ID" value="B7C42_07040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="30"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="351"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR40905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="600" mass="63939" checksum="A681482259B70F22" modified="2017-10-25" version="1">MNSAAPHRDSIPALLRRLDRHAPVPRTALLGIALLVVVAGGGRIVIPVTIQYALDHALLADTTPAARSHIVFEAVGVGVAAVLAAMLSSSLVNRRLIRIVERFLFELRTAAFTRVLRRDPADRGTDSGGDLVARVTNDLDMVTVYAQSGGVTLVQNLCQMVLALAVMAVYSWPLAVLVLIIGTLVPIAGRRLQRLVSQRFDAVRVRIGELYAGLLELLLGIDTIRGYGIEERMRAGTERRIDAVLTAQRKTLWPVGFNMSVGEWASGLITTSVIVVGTAAGIGPLHASAGDIVAFLFLATFFVRPMQFAVTSLADARNAEAGLRRVAAVLDAPISSRTPRHTTLPPGAATVELAGVTFGYVPGRLALGPVNLRIAAGEHVAVVGETGCGKSTFAKLITRQLLPSGGRVALWDIDTGDIDGGVLARRVAIVPQDPFLFDRSIEDNIALGRDGASREAVLDVLDRLGLREWIDHLPDGLQTVVGRRGEALSAGERQLVALARTALTDPDLLVLDEATSGVDAATDVRLQRALVQLTSGRTTVTIAHRLHSAEIADRILVFHAGRIVEDGPHEQLSAAGGRYARLHAAWAPDAANRSRGELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWU5</accession>
    <name>A0A231GWU5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41058">
        <property type="protein sequence ID" value="OXR41058"/>
        <property type="gene ID" value="B7C42_06828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013053785" evidence="2">
        <location>
            <begin position="35"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="112" mass="11341" checksum="E694CED7CED887E5" modified="2017-10-25" version="1">MTHRPRVRSLLAATAGAALLALGSGLLTAAPAGAAPNAPVPVHDPNYPLGGDAQHPGTPEQDPQAEKAEKLGGHATTDIIELATDTTTKIVEMGADVLKCGLNIAMPSVKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX07</accession>
    <name>A0A231GX07_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cynS</name>
        <name evidence="5" type="ORF">B7C42_06735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783052.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41139">
        <property type="protein sequence ID" value="OXR41139"/>
        <property type="gene ID" value="B7C42_06735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009439">
        <property type="term" value="P:cyanate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="PTHR34186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="SSF55234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate_lyase" evidence="4">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="16618" checksum="6AC1C4900F32C2CF" modified="2017-10-25" version="1">MVHAQFDPAARQALAATAVEAKIAKDLTWQQIADTAGYSTAFVTAAILGQHPLPKQAAEAVAELLGLGDDAAALLQTIPTRGSIPGGVPTDPTIYRFYEMLQVYGTTLKALVHEQFGDGIISAINFELDVRKVPDPEGGERAVITLDGKYLPTKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX70</accession>
    <name>A0A231GX70_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaK2</name>
        <name evidence="6" type="synonym">dnaK</name>
        <name evidence="10" type="ORF">B7C42_06871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41101">
        <property type="protein sequence ID" value="OXR41101"/>
        <property type="gene ID" value="B7C42_06871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR41101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="626" mass="67101" checksum="9F777B6ADA03F9BC" modified="2017-10-25" version="1">MATAVGIDLGTTNSVIASWQGGEPVVISNTEGARTTPSVVAFTESGERLVGQLARRQAILNPKGTIYSAKRFIGRHYDEVSEEAKAVSFDVVPGDNGEARFDVRGRKYAPEEISALVLRKLVDDASKFLGEKVKEAVITVPAYFNDAQRNATKDAGRIAGLDVLRIINEPTAAALAYGMDKQTHETVLVFDLGGGTFDVSLLDVGDGVVEVRATAGDSHLGGDDFDRRLVDYLADEFQRAENIDLRKDAQALQRLFEAAEKAKVELSSVTQAQVNLPFVTADANGPKHLTTTVMRSKFEDLTADLVERCLGPVKQAMSDAKVTANDIDEVILVGGSTRIPAVQALVRRLTGGKDPNMSVNPDEVVALGAAVQAGVLKGEVSDVLLLDVTPLSLGVETQGGVMTKIIERNTTIPVRRSEVFATAEDNQSAVDVVVLQGERERAADNRVLGRFRLEDIRPAPRGEAQVEVTFDIDANGILNVTARDKDTGKEQGITISEQGNLDQSEVERMLAEAERNRAEDEALRKAVDARNALDSVAYQVERRLAELGDSAPPHEKARAEMLIADARKAVQDNASPAEVEPLTSELQQLLYGLASAQTGGDGQQAGGGGASSSDDDDVIDAEFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXB6</accession>
    <name>A0A231GXB6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Geraniol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.347</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">geoA_2</name>
        <name evidence="4" type="ORF">B7C42_06662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.347" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000021">
        <property type="protein sequence ID" value="OXR41264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41264">
        <property type="protein sequence ID" value="OXR41264"/>
        <property type="gene ID" value="B7C42_06662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="367" mass="37434" checksum="1412BA041B62260E" modified="2017-10-25" version="1">MEIKAAVLGGVDEKFSVETVELGAPAADEVVVEIVGVGICHTDLAIRDGHLPFPLPGVVGHEGSGTVVAVGAEVSSVAVGDAVAVSFNSCGSCAQCDHGAPAYCANFMAYNFGGVRPDGSSALAQDGKTLGSNFFGQSSLATHAVAHERNVVKLPDDAPVEIVGPLGCGIQTGAGAVMNSLDVQAGSSLVVAGGGAVGLSAVLAAVVREARVIIVVEPHESRRKLAVDLGATHAIDPNAGPVSEQIRAIVPEGADYAIDTTAIPDVLVQLVLSLGARGALGLIGVPSNPEAALPVPLIPLLIQGLSVRGITEGDADPHTFIPQLLDLHRQGRFPFEKLITTMPLAQINEAIEAQHRGEAVKVVLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXK2</accession>
    <name>A0A231GXK2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase FadD17</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_06469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780526.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41326">
        <property type="protein sequence ID" value="OXR41326"/>
        <property type="gene ID" value="B7C42_06469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="49"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="465"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="589" mass="64470" checksum="CD3ADA8484C72976" modified="2017-10-25" version="1">MTAEARNTISLWDLARRLPAMAMETPGMLRGATGMLVRADDKSSVGLYFQKAARRYPNRPFLRFEGREYTYGEANTEVNCFAEVLAQRGVRRGDVVGVLMTNRPETLFVVLATVKLGATVGLLNHNQREQVLAHSFGLLNSTVNVIGEECEEALRSLPEPPPNLLYTQELQELARAADPADPAVCADVRARERAFLIFTSGTTGLPKASVMTHLRWTKSMAGLGGLGIRLRGGDTMYCCLPLYHNNALTVALGAVLGSRATLALGRKFSVSNFWNEVVATRSTAFIYIGELCRYLLNQPESPREHEHSVRLAVGNGLRPELWDEFRRRFGIGRVVEFYGASEGNIAFINAFGVDRTAGFGPLPYAVVEFDEETGKARRYPDGRLRKVASGGVGLLLAKVTDRSPFDGYTDKSATESKLVRNAFDDGDCWFDTGDLVRDQHWRHIAFVDRLGDTFRWKGENVATTEVEGAFDGAPGITEAVVYGVDVPGADGKAGMAAVTLDADADFDGSALAARLYDRLPGYAVPLFVRVVPELETTSTFKSRKVDLRKQGFASDDATAVYVLKGRDQGYVPFYASYPDEVAAGTAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXS8</accession>
    <name>A0A231GXS8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase fadE25</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_06549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41406">
        <property type="protein sequence ID" value="OXR41406"/>
        <property type="gene ID" value="B7C42_06549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR41406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="42900" checksum="635CF371F13EDB39" modified="2017-10-25" version="1">MKLALSPDEVAFRDELRTFFRTEIPAEIRDKVENGRELSREDIVTAHKLLHAKGIAVPKWPVEWGGQDWTSMQRHIWEDEMQLACVPEPLTFNANMIGPVIAQFGSEELKQRFLPPTAALDIWWCQGFSEPDAGSDLASLRTTAVRDGDSYIVNGQKIWTTLAQYADWIFCLVRTDPNAPKKQAGISMLLFEMNSPGVTVRPIKLIDGRHEVNEVFFENVRVPADQLVGEENAGWTYAKFLLGNERTGIAGVGRTKVVIATAKKHAAQIPTGSGTLLEDPVFAARVAELENELLALELTLLRVVANSAEGKPNPVSSVLKLRGTELQQAATELMLDVAGPDAVPVGADDIAAPDWAQRTGPTYLNYRKTSIYGGSNEVQRTIIASTILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXY3</accession>
    <name>A0A231GXY3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41459">
        <property type="protein sequence ID" value="OXR41459"/>
        <property type="gene ID" value="B7C42_06350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="51" mass="5428" checksum="98D320DAEB378761" modified="2017-10-25" version="1">MNHPDNTGAHTDAEQDDQETQGKRTVDAPPETSGKLAGPGPARDQKEDPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY67</accession>
    <name>A0A231GY67_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41512">
        <property type="protein sequence ID" value="OXR41512"/>
        <property type="gene ID" value="B7C42_06404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7453" checksum="EB00C6934D3164C2" modified="2017-10-25" version="1">MAADFAHRVKLNVDLFFRYLRTGIEPGEDDTADMVRLAVERVRDGAAVTDVLDAPFMLNLFGKPVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYJ1</accession>
    <name>A0A231GYJ1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778297.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41659">
        <property type="protein sequence ID" value="OXR41659"/>
        <property type="gene ID" value="B7C42_06300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="266" mass="29515" checksum="EAF02DC485455D59" modified="2017-10-25" version="1">MPTHTAGDLLRHWRRTRRLSQLELAGRAETSTRHLSFVETGRSTPSRQLILHLSEELDIPLRERNRMLLAAGYAPVYAEPGLDTPTMAPVRTAMRQILTGYEPYPALAVDAQWNMVDANSGVALFLDGIPADLLTPPVNALRLSLHPQGLAPRILNLAQWRGHLFERVDRQIEATGSADLAALRSELLGYPGGRDDPGLPEPDQAVVPLRLRHHDGERGDIELDFISTMTIFGSPMNVTVAELAIESFLPASPETAEFLRRRSQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYN2</accession>
    <name>A0A231GYN2_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778318.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41631">
        <property type="protein sequence ID" value="OXR41631"/>
        <property type="gene ID" value="B7C42_06272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="87" mass="9092" checksum="61014A22416D5F0A" modified="2017-10-25" version="1">MVRLPLTPAQVEAGRRLGAHLRAVRGDRDPAEIARAAGISPETLRKIESGRLPSPAFGTVVGLSGALGIPLQELAEVWQSARLSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ14</accession>
    <name>A0A231GZ14_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator VirS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">virS_3</name>
        <name evidence="5" type="ORF">B7C42_06157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41815">
        <property type="protein sequence ID" value="OXR41815"/>
        <property type="gene ID" value="B7C42_06157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="232"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR41815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="339" mass="37998" checksum="4ED5E569A58B61DA" modified="2017-10-25" version="1">MKPLARYAALNDYVDLGQSLGLDPARLIREAGLDPAGLSLQDRWVPAAAVTELLERSAAESGRQDFGLLLAERRRLSNLGPLSLVIREEPDVRSALELMVRHQHTYNESLHIRLTERNGIAHVRLSLDIGEHRSTRQATELAMGAMQGILRGFLGATWQPAETTFAHSAPRDRSTHLRLFGPQLRFEHEFSGITLYTSDLDTPNPMSDPLLRPYTQQLLGAVDTAHETAMRDRVQELVEMLLPTGRCSADQIARSLGVDRRTVHRRLADEGHTYSEIVNTTRLDLARRVVGNQGRSLTEIAEMLGFSSPASFTRWFRSHHGCSPSQWRRAASKNTVDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ20</accession>
    <name>A0A231GZ20_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780736.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41838">
        <property type="protein sequence ID" value="OXR41838"/>
        <property type="gene ID" value="B7C42_06180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="165" mass="18777" checksum="3FAA768B62045138" modified="2017-10-25" version="1">MCPRPIEPARISADLKRALGFYHGTVEDLTRELLRVLGVNETDRRALEIVLADDEKSTTPGMLAERLGITAAGVTIMLNRLEKQGYIARSLHPTDRRRVIVMATDLAAHRIQQLVVPMIVESYKMLLSWYDSAELEIIADFLTRAGELQRIHRQRLRDVDPFSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZ99</accession>
    <name>A0A231GZ99_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000017">
        <property type="protein sequence ID" value="OXR41841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41841">
        <property type="protein sequence ID" value="OXR41841"/>
        <property type="gene ID" value="B7C42_06183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="168" mass="17342" checksum="0E2192C2CA840B9F" modified="2017-10-25" version="1">MSRPVNLVVGAAAKVGGAAGRVLGFGFAVGRHVPGVEPVLAELGQRGAETLEAVDDLTERVLQAVIGRIVRTAVGAVDLTAIVVDNVDLDAVAERIDVDKIIGRVDLVGLADTVIDGVDLPRIIRESTDSMSAEAVLGIRSQGMHADDAVAGFVGKLLRRTPSESGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZI1</accession>
    <name>A0A231GZI1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hbpA</name>
        <name evidence="4" type="ORF">B7C42_05969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR41985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41985">
        <property type="protein sequence ID" value="OXR41985"/>
        <property type="gene ID" value="B7C42_05969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012420938" evidence="2">
        <location>
            <begin position="19"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="99"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR41985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="520" mass="55969" checksum="0F21B5607AE9089D" modified="2017-10-25" version="1">MTRAHRLSLLLAAVTAIAAVPLSSCGTGGDSGGSPAVQTTQAPTPPEDRLDTDATVNVRLTLEPTSLNTFTTAGVALDQVLLDNVYQGLVSIDTNDRDKIVPALARTWELSPDGLQYTFHLAPNATFHDGSPLTAADVVWSLRQEIAPGARALKAADFSSVADVSAPDPATVRIVAKQRDTTLLWALSQRGGIVYKQGTDFAGLDGAENGSGPFRLAQWNRGSSITLARNDSYWGARPKVAKVVFHYIKDPNAANNAEATGQTDIQAGADPTLLQPFTGNDRFTVLRGTTTDKYTLAFNGTRAPFTDPAVRHAIRQAIDTQAAIRTYGAGIAIGSDVPPQDPWYEDLTAIDSYNPDNARKLLAGAGFGNGLALTLDVPNIYPASITDLLVSDLKKVGITLTVHQVEFQTWLSKVYAGKDFELSLVDHADARDLANYTKPTYYFGYDNKQVQQWYDQARTAATDAERDALLKKVARQISEDAAAEWLLLAQTTTVVRQGVYGVPQAETSNRYNLATLAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZK9</accession>
    <name>A0A231GZK9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000016">
        <property type="protein sequence ID" value="OXR42057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42057">
        <property type="protein sequence ID" value="OXR42057"/>
        <property type="gene ID" value="B7C42_06041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="83" mass="9345" checksum="AD43D8E65189F07C" modified="2017-10-25" version="1">MNQPMGLGRLGVMDRNRTGHHIYSRETATSFVISAVESTGAATRDDFDIDRIVTTAHALVNDWDFDAMQPEAFWRIASSFIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZP3</accession>
    <name>A0A231GZP3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782827.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42078">
        <property type="protein sequence ID" value="OXR42078"/>
        <property type="gene ID" value="B7C42_05677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="133" mass="14663" checksum="31B956BCC7D388F3" modified="2017-10-25" version="1">MTRETTSAAVESTIRSLEDQRYAAVIAGDVDGFLALAHPDLVYTHSNAEVDALDSYVDKLRSGHYVYHHIDHPVSRIVVAGDTAVVVGEMHADITAGGVRKKLANRALAVWVRDRDRWLLLAYQPTVIPGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H022</accession>
    <name>A0A231H022_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative heat shock protein HspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hspR_2</name>
        <name evidence="2" type="ORF">B7C42_05804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42205">
        <property type="protein sequence ID" value="OXR42205"/>
        <property type="gene ID" value="B7C42_05804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="117" mass="12785" checksum="CB620346DD0801B2" modified="2017-10-25" version="1">MGSDRREGHLPGSGQAVYPISVAAELAGIEIHTLRLYEQHGLITPARSAGGTRRYSGDDLARLQRITALTRQGIHLSAIARILDLEDDNSALRAHNTALTAERDQLRDTITGRQLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0R9</accession>
    <name>A0A231H0R9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42371">
        <property type="protein sequence ID" value="OXR42371"/>
        <property type="gene ID" value="B7C42_05570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="191" mass="19387" checksum="6A1C450D2FCFEC0A" modified="2017-10-25" version="1">MSTLAVTKSERAALIRLYLGRGVLAVAWAAVFATAHESLDALAVGLLVAYPLIDAVSSLIDYKATDAGPERRVTAFNATLSTLAAVAAGTAAITGGVAATLATFGAWAVLSGAAQVAVGLYRRGPELGKQWPMLIAGGLSFLVGLFYIGQSVGDAPSLDVLSVYATGGGVFFIVQAGLLVWKGRSTSLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0W7</accession>
    <name>A0A231H0W7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rsmI</name>
        <name evidence="9" type="ORF">B7C42_05632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780721.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42431">
        <property type="protein sequence ID" value="OXR42431"/>
        <property type="gene ID" value="B7C42_05632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR42431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="281" mass="29760" checksum="4763ECBB745BD7AB" modified="2017-10-25" version="1">MGEHGGRLVLAATPMGDIGDASQRLRDALASADVVAAEDTRRTRALAKALEVEITGRVVSFYDHVEAARIPLLLDEIESGRTVLLVTDAGMPSVSDPGYRMVAACIERDLPVTCLPGPSAVTTALALSGLPMERFCFDGFAPRKSGQRKQWLATLVTEPRAVVFFEAPHRLAGCLADAAEVLGPGRRAAVCRELTKTYEEVVRGGLGELADWAVEGARGEITVVVEGAQPVSADPVDLVDEVEELVADGTRLKDACAQVAARAGGVSRRELYDAVLAARAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1F8</accession>
    <name>A0A231H1F8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42672">
        <property type="protein sequence ID" value="OXR42672"/>
        <property type="gene ID" value="B7C42_05450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="17512" checksum="F853022573464C68" modified="2017-10-25" version="1">MTTPPTTHAELVPRLMSAFGRFRRQVGRIAGRSFDRPGVSASQAEFLRLVGRNPHISVKSAAAEMGLAPNSVSTFVTALVKDELLVREPDPADRRVMRLSLPAHVQRDVDDIRRRRHDIVATALDALTPAERDDLLRGLAVIDKITELLHDHEQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1P6</accession>
    <name>A0A231H1P6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine catabolism regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pucR_2</name>
        <name evidence="2" type="ORF">B7C42_05107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42769">
        <property type="protein sequence ID" value="OXR42769"/>
        <property type="gene ID" value="B7C42_05107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="42725" checksum="FC2ADCB9C0724AC8" modified="2017-10-25" version="1">MSESSEVPNSPRQRLLVRMRAERDALAARIVDRARADIPDYRTIEAADLLPTTTAIMDRLFASLAGTADIEPPEGARMTDYGRIRANQDVSMEALLRAWRLAERLHLETLSAVAAECGADDAVLFEITRDLLRLVDEAATSFSDAHHEVERTRAGHDRIQRAEFTRSVLAGTISATELTLGIQRYGLRADAEYRAFRARADAAPPTEFDRLLRPQGADYAFRTVIDGDYAGFTDRTIHIPVTALLAFGPPRPLAEAPRSFRLAGRALATAAALGHTGTCEFDGLGLLPGVAADPELGAELVRRYLAPLGSSGSATTLIDTVTAYLDTGMRIEATAQRLIVHPNTVRYRIARFEELTGCDLRRAHTGAQVWWAIQYDRLVRPGATNFASAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1R2</accession>
    <name>A0A231H1R2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bmr3_7</name>
        <name evidence="8" type="ORF">B7C42_05095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42757">
        <property type="protein sequence ID" value="OXR42757"/>
        <property type="gene ID" value="B7C42_05095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="30"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR42757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="844" mass="88535" checksum="FAE9018BAAEF1CC7" modified="2017-10-25" version="1">MTTSTIREPAAQPASGPAPGTLSHRQILTILSGLLLGMFLAALDQNIVSVAIVRIANSLHGFDQQAWATTAYLITATISTPLYGKLADIYGRKPFYLLAIGIFVVGSAACTFATSMYELAAFRAFQGLGAGGLMSLAFTIIGDIVPARERVRYQGYFMMVFGTATVAGPVLGGFFSDYDTLWGIDGWRWVFLVNVPIGVLALAVVAKVLNVPHERQRHRVDWFGAIALAICVVPLLIVAEQGRGWGWESPRALICYGIGAVGLVLFVLVEFLMKDAALIPLRLFRNSTFSITILGGFIVGIAMFGAISMVPLYLQVVRGYSPTKAGLLMLPLVLGIMIGSLIAGQVTKLTGRYKILPVLGTFVIACGAALYAQVHYDSPLWQPLVYSAVIGFGLGGCMQTLIIAAQNAGPRSDMGVSTASATFFRQMGGTLGVAVFLTILFNLLPHKIIDAFGGVLPPGFDTGKLDQLQSNTSGIAALPAQVRDPILIGFTDSLHGVFYAAAGVALLACVVLLFMKEIPLQDSSAPPQRAEQPQDARTVAEAEAAEAPELWEPEQLWEADGEAARPESAPALAESAAHTAFPEVIGDVPGDAPVSGHIHREDGQSIPGAALTLIDQRGHQVSRATTDGAGGYRLSVPDAGNYVLIVSAEGHQPAAVNVAIGSEPQTVDLTLQGSGELSGIVTEGPGRPLAGVTVTLTDRRGEVVGAAVTGADGAYACHGIVAGTYTLVAVAGHRRPDATTLTVPQTGMLRYDIELAPTAVLSGRVRSERGPVAHAHVAVLDSGGAVVAAALTDGDGRYRIDDLPAGDYTVVGRGYPPASARVAVDGERIAHDLRLCYDGAADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2B6</accession>
    <name>A0A231H2B6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42983">
        <property type="protein sequence ID" value="OXR42983"/>
        <property type="gene ID" value="B7C42_04869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021607">
        <property type="entry name" value="DUF3224"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11528">
        <property type="entry name" value="DUF3224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SSF159238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="13979" checksum="AE772EE350C5DDAE" modified="2017-10-25" version="1">MTDQHQASTVEARFQIVDFTETVYDQPEVGPKLTRVQIRKNYSGVIEGSGVVEVLTAQGDSGAGFVASERIDGILDGRRGSFVIQHGGVMQGDTQSTYGTIVPGSGTGELVEISGQATEVQREVLTLTYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2C0</accession>
    <name>A0A231H2C0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42990">
        <property type="protein sequence ID" value="OXR42990"/>
        <property type="gene ID" value="B7C42_04876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="132" mass="14613" checksum="B37BD6015411B958" modified="2017-10-25" version="1">MTFTSNEQKFLAEAGIGRLATVSPDGVVQNNPTNYRVNADGTIDIGGMRMRASRKYRNVEAGSRVSFVVDQQVSLEPYEIRGIEVRGTAVALDDEEPPFPPQERAVIRIHPERIISWGIDGGSFEFTSRTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2W7</accession>
    <name>A0A231H2W7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43203">
        <property type="protein sequence ID" value="OXR43203"/>
        <property type="gene ID" value="B7C42_04625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="283" mass="30239" checksum="6E6744C5E8BA6252" modified="2017-10-25" version="1">MDKTVGKLEDRVVFVTGAARGQGRSHAIRCAEEGADIVGIDICADIDLVPYKLGTSEDLDETVRLVEKTGRSMLARKADIRDLASLQSAFDAGVERFGHIDTVLANAGVLLSNTAEADAAEAFRTGIDLLLIGPWNTVRVAMPHLIERGRQGHRDGNIVVTSSMAAMLGLGNGRGGDDAYGMAKLALTGMVRQYANYLAQYHIRVNGVAPTNCATPMVTQNPELVNVLGAYPNLANAMQTLLPDLPMIEPRDVSEAIVFLITESGRSFTGSTLNVDAGMATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Z7</accession>
    <name>A0A231H2Z7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC_dehydrat_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43214">
        <property type="protein sequence ID" value="OXR43214"/>
        <property type="gene ID" value="B7C42_04636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="148" mass="16270" checksum="5830AB196AEC9155" modified="2017-10-25" version="1">MNEPAPVGTVGTPWEVIVERGKIREFARAMQSENSAYEGPDAIVPPTFLITAGQWAPPGARVDVGFDRARLLHGEQEYIFHGPLPRAGDHLTAREKVVDRFEKPGKRGGVMRFAVVATEFRTGDGELVAEARATFIETAPREKKEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3C5</accession>
    <name>A0A231H3C5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B7C42_04250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43383">
        <property type="protein sequence ID" value="OXR43383"/>
        <property type="gene ID" value="B7C42_04250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR43383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="207" mass="22127" checksum="D8A505650699601D" modified="2017-10-25" version="1">MSGTPDDSRAKLVAGAAEMIRRRGLAATSVRDLAKFADAPLGSTYYYFPGGKAELATEAVALAGDRTAATLARELRKGSVEGLHSFLRRWRKNLLDSDFRAGCPVLAVSVEDVPDAEGRPREAAAAAFARWTDLLARSLREDGAEQAEAERTATLIIAALEGSLAMCRAERSTTALDRIDDQLESLLKAAIPAPGTIPPSRTRSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3T2</accession>
    <name>A0A231H3T2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43573">
        <property type="protein sequence ID" value="OXR43573"/>
        <property type="gene ID" value="B7C42_04441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="8856" checksum="9E16B93A58A765F2" modified="2017-10-25" version="1">MALGRLGNLPWGSRSRRDLRQARVLRGAGAPENRRGVPTRGVGRVEIPAATIRRAARIPVGRTVMCAGPVAPQTGFRDDAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3T5</accession>
    <name>A0A231H3T5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoglutarate oxidoreductase subunit KorA</fullName>
            <ecNumber evidence="4">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">korA_1</name>
        <name evidence="4" type="ORF">B7C42_04388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="4"/>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039779220.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43520">
        <property type="protein sequence ID" value="OXR43520"/>
        <property type="gene ID" value="B7C42_04388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="262"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="650" mass="68657" checksum="366BE53D46AB634A" modified="2017-10-25" version="1">MVSNQGVDRPTGSEKLEKVVIRFAGDSGDGMQLTGDRFTHEAAAFGNDLATQPNFPAEIRAPQGTLPGVSSFQIQIADYDILTAGDQPDVLVAMNPAALKANIDDLARGATVIVNTDEFTKRTLAKVGYERDPLTDDSLGDFVVHRVPMTSLTLTATEPTGIGKKDGQRAKNMFALGLLSWMYGRPLGGTEAFMREKFAATPEIGEANVLAFRAGWNYGETTETFATTYEVAPATLPRGTYRQITGNTALAYGVIAAGQLSGLPVFLGTYPITPASDILHELSKHKNFGVTTFQAEDEIAGIGAALGASIGGALGVTSTSGPGLALKSETIGLAVMTELPLVIIDVQRGGPSTGLPTKTEQADLLQALYGRNGESPVAVVAPRSPADCFAAAVDAARIALTYRTPVLLLSDGAIANGSEPWSIPRVGDLEPIDPAFEPPAEADAADGHPFQPYARDPETLARPLARPGTAGLAHRIGGLEKADGSGNISYDPANHELMVRLRQAKIDGIAVPDLEVDDPDGTAELLLIGWGSSYGPIGEACRRARRRGVPVAQAHLRHLNPLPANTGEVLRRYRRVVAPEMNGGQLALLLRGTYLVDVQPWTKVAGTAFSAQELVGVIDAALDGSIGELEQNKAFDARARATYRTTGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H3U7</accession>
    <name>A0A231H3U7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_04398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000009">
        <property type="protein sequence ID" value="OXR43530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43530">
        <property type="protein sequence ID" value="OXR43530"/>
        <property type="gene ID" value="B7C42_04398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="63"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR43530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="447" mass="47217" checksum="A826BBA83DB87353" modified="2017-10-25" version="1">MSEGLFEAPELEDVSGTSAALPPAGRMSPLAVRMRPASLDEVVGQQHLLGPGSPLRRLIEGSGAASVLLYGPPGTGKTTLAALISTATGRRFEALSALSAGVKEVRAVIELARRRLLAGEQTVLFIDEVHRFSKTQQDALLAAVENRVVLLVGATTENPSFSVVSPLLSRSLVLQLKSLSDNDIRTVLRRAIDDERGLAGQYTVTEAALDHIVRIAGGDARRSLTALEASAESSLDGTVDVDLVEASVDKAAVRYDRAGDQHYDVISAFIKSLRGSDVDAALHYLARMISAGEDPRFIARRLMIQASEDVGMADPTALQTAVAAAQVVQLVGMPEAQLALAHATIHVATAPKSGAVAAAIGAAMSDIAAGKAGAVPPHLRDGHYAGAAKLGNAQGYKYPHDHPDGILTQQYPPDELVGADYYTATDHGYEREIGPRVTKLRRIVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4R8</accession>
    <name>A0A231H4R8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dapA_2</name>
        <name evidence="9" type="synonym">dapA</name>
        <name evidence="11" type="ORF">B7C42_04053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43818">
        <property type="protein sequence ID" value="OXR43818"/>
        <property type="gene ID" value="B7C42_04053"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR43818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="30344" checksum="4DEBD7740461F784" modified="2017-10-25" version="1">MTFSGLFVPLVTPFTADGELACDALGRLAHDVLDAGAAGIVALGTTGEPATLTPEEKRRVVDICAQVCAERDAPLIVGTGSNSTADSEHALAALDERVAAALTVVPYYTKPSQRGVVEHFRRLAQRSPVPLLIYNVPHRTGRPLDPETLIELAELPNVAGFKHAVGLVDETTVAWLAAVGDRTTVLCGDDLYATPLLAMGAQGAILTCSNVAPAAYAELIAAWRDGRVEAARKIGNRLVELARALFAEANPTVVKGVLAAQGRIPSAHVRLPLLPACAESVSAALAAAGPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H4Z8</accession>
    <name>A0A231H4Z8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000008">
        <property type="protein sequence ID" value="OXR43925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781046.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43925">
        <property type="protein sequence ID" value="OXR43925"/>
        <property type="gene ID" value="B7C42_04164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="115" mass="12352" checksum="7C6E9095B5531D29" modified="2017-10-25" version="1">MLTENRTLSFVAVALGVYTALSPIWTDHSNRAMWTLIVLGVLIALTGVVQFTRPGIAGTDYAMGLFGVLLFISPWVMNYSGFSAASWTAWIVGVLTVVVALAALPQVSARMHTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5S6</accession>
    <name>A0A231H5S6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B7C42_03716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44157">
        <property type="protein sequence ID" value="OXR44157"/>
        <property type="gene ID" value="B7C42_03716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="177"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXR44157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="326" mass="34124" checksum="59164A2117B90478" modified="2017-10-25" version="1">MRLVRVRGAVNDVEEATGGGGAAGGRGRWGRSPAGGGVAVGAGAYLIWGMFPAFFGLLDFAGPVEILAQRILWTLVVVLVLLLAAGRLRELGAIDGHTWRLAAVAAAAISINWGTYVYGVTSGHVVECALGYFINPLVTVLFAVVLFRERLVWPQWVALGLGGAAVVVLTVDYGKPPIIALVLACSFATYGLVKKVIRLDPMRSVAAEGVVSAPFALAVVIALGVRGDAEFGHGAGHTALMVATGPVTLLPLLLFAFAASRVPLSTMGILQYLTPALQLAWGVLVGHEPMPASRLIGFGLIWTALAVFTGDALRRSRRLARRDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5T3</accession>
    <name>A0A231H5T3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 20" type="primary">uvrB</name>
        <name evidence="20" type="ORF">B7C42_03815</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44254">
        <property type="protein sequence ID" value="OXR44254"/>
        <property type="gene ID" value="B7C42_03815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="66"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="470"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="690"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="686"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXR44254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="735" mass="82499" checksum="FE9106041081C212" modified="2017-10-25" version="1">MPRFTLVTMAFATEIPADSDAPGEQPLAHSEFRPIGAIERSDGRFEVVSEHRPAGDQPAAIAELERRLRGGEKDVVLLGATGTGKSATAAWLIERVQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYLDRSVQLEVGTEVERDRLLRLLVDVQYTRNDMAFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGDVVRQVDTLRIFPATHYVAGPDRMERAVADIETELEQRLANLERQGKLLEAQRLRMRTQYDLEMIRQVGFCSGIENYSRHIDGRPAGSAPATLLDYFPEDFLLIIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSAVDNRPLTWEEFADRIGQTVYMSATPGPYELGSTGGEFVEQVIRPTGLVDPQVVVKPTKGQIDDLVHEIRTRTERDERVLVTTLTKKMAEDLTDYLLGMGVRVRYLHSEIDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSATSLIQTIGRAARNVSGEVHMYADKVTDSMRQAIDETERRRAKQVAYNEANGIDPKPLRKKIADILDQVYREADETEVEVGGSGRNASRGRRAQGEPGRAVSAGVYEGRDIANMPRAELADLVAQLTDQMMNAARELQFELAGRLRDEIADLKKELRGMDAAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5X3</accession>
    <name>A0A231H5X3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44294">
        <property type="protein sequence ID" value="OXR44294"/>
        <property type="gene ID" value="B7C42_03855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="181" mass="19588" checksum="7E92D48EDC462CBB" modified="2017-10-25" version="1">MSTDRDAGNYPIGSISARWPAADIAAAWQRELPGVRTESIEIITPVWRIAKALADDRRRTLSELGVDPSTLDLLSVIRRSGPPYELTTREITDRTMITAGAVSQRIARAEQAGLVERSPSAVSHRAVAVRLTEAGHTLIEATVRQLLEHEADLISALAPAERVALTGLLAGLEQALVTPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Y0</accession>
    <name>A0A231H5Y0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777664.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44304">
        <property type="protein sequence ID" value="OXR44304"/>
        <property type="gene ID" value="B7C42_03865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="268" mass="29076" checksum="99148E8ABB3B2D23" modified="2017-10-25" version="1">MTASDSSATSDAEAPSSARIYDYALGGKDNYEVDRRALEKVMEGFPTVRIAARHNRQFMHRAVDALADAGVKQFLDIGTGIPTEPNLHQVAQERAPEARVVYVDHDPVVLAHARALLAGSPEGRTTFIQADLTDPEAILSAPELHETLDLASPVALSLVAVLHFLSADQNPAGVLKTLLDNLAPGSFVIASHITADLDPEGMDRALDMYRRSAVHAQARTRDEFAAFFDGLELLDPGVVAVNRWRPGIEPPSWLDKQVNCWGAVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H5Y9</accession>
    <name>A0A231H5Y9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_03816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777581.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44255">
        <property type="protein sequence ID" value="OXR44255"/>
        <property type="gene ID" value="B7C42_03816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="17232" checksum="28C267A0F27CC4C7" modified="2017-10-25" version="1">MSKDVDPIPEGYHSINCFLAVPDGNKAIEFYSAVFGAKVLSRNDLPDGQPAHAELAIGDSTIQMGMPIPEHGVRAPESDWVHTSIVHYCPDADAVVARAAEHGAARVEEPQTFVTGDRYGLVMDPFGHRWVVMTRVEDVSREEAERRVDEWMATQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H605</accession>
    <name>A0A231H605_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter glutamine-binding protein GlnH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glnH_3</name>
        <name evidence="4" type="ORF">B7C42_03798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44237">
        <property type="protein sequence ID" value="OXR44237"/>
        <property type="gene ID" value="B7C42_03798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011968916" evidence="2">
        <location>
            <begin position="32"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="63"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="302" mass="31889" checksum="A2968395FCDE7300" modified="2017-10-25" version="1">MSVRLGARGYILRAACVIVGAAVLAAGCADNTEDESPKVPKVPVTKVESIAAQLPPKIAQAGRLVVGVNVPYQPNEYRDPHTGQIIGFDVDLMDAVAGVLGVRADYQEADFEKIIPAIEAGTVDVGMSSFTDNLTREKTVDFIDYFSAGIQWAQRKGRPVDPNNACGKKVAVQRTTTEDIDEIPAKSKACTDAGKPEIHKMSYDEQSAAATALVLGQVDAMSADSPVTAYAIKRNPDTIEAAGPVFEAEPYGWPVPKGSPLAPVLQAALQHLIDSGVYRTIAQNWGVEAGAITTSVINGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H661</accession>
    <name>A0A231H661_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromate reductase</fullName>
            <ecNumber evidence="2">1.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_03902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44341">
        <property type="protein sequence ID" value="OXR44341"/>
        <property type="gene ID" value="B7C42_03902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="262" mass="27427" checksum="8691C515D7D21706" modified="2017-10-25" version="1">MTSVLGLAGSLRRQSYNRMFLEVVPHLLPFACRYQVFDGLGEVPLYNEDIDTAAPPPGVRALRAAVAASDGVIVASPEYNQSVPGVLKNALDWLSRPHGGGALRGKVIVPVVVTLSRSNGARGLADLNRVLSYLGNTVLYQPEIVLASAPSLLRPGADGSVDITDPAVRALVALALEQFGNVLGAGTARAGAEFVAAHRAVVERARFAPMVREALSRGAPPGVVAERLRNAGISAHEAQEWISAEMASGPVLSSNGHRSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H666</accession>
    <name>A0A231H666_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ppa</name>
        <name evidence="6" type="ORF">B7C42_03183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030517366.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44394">
        <property type="protein sequence ID" value="OXR44394"/>
        <property type="gene ID" value="B7C42_03183"/>
    </dbReference>
    <dbReference type="GeneID" id="66718526"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR44394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="18519" checksum="F288793C43E31E51" modified="2017-10-25" version="1">MEFDVTIEIPKGQRNKYEVDHETGRVRLDRYLYTPMVYPADYGYIENTLGSDGDPLDCLVLLPESVFPGVIVEARPVGVLLMSDEAGGDEKVVAVPAGDKRWDHIQDVNDIPEFERKAIEHFFEHYKDLEPGKWVKVDGWDGRAKAETLADEAFKRLQEQGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H695</accession>
    <name>A0A231H695_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD-box ATP-dependent RNA helicase CshB</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cshB</name>
        <name evidence="3" type="ORF">B7C42_03153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44365">
        <property type="protein sequence ID" value="OXR44365"/>
        <property type="gene ID" value="B7C42_03153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="81"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="304"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="791" mass="83788" checksum="87E9C321D1E35DD4" modified="2017-10-25" version="1">MNPKGPGSDAAPAEAIGYGTSLLNRVLFGVPDAESRITHVTELPARAARSTGWPSWAAPDVVDALRESGVDAPWTHQIRTAELASAGTHVVVCTGTASGKSLGYQLPVLTDLQRDSRATALYISPTKALGADQFRAAAQLTHAGSLRDIHPATYDGDTPPEVRQWVRANARWLFTNPDMLHIGILRAHQRWARMLRRLRYVVVDECHAYRGVFGSQVAMVLRRLRRLAAHHGANPTFVLCSATSADPAAAAERLIGAPVTAVTDDGSPQGARTVALWEPPLLGDLSGENGAPVRRAATTEAARIMTDLVVEGARTLTFVRSRRAAEVVAIDVQRMLAEVDPSLAGRVAAYRAGYLAEDRRELENGLADGSLLGAATTTALELGVDIAGLDAVVMAGFPGTVASFWQQAGRAGRRTQGSLVLLVARDDPLDTYLVHHPHALLDKPVEATITDPHNPYVAGPHLLCAACEHPLTDAEIDDLGVRDVAADLAAQGLIKRRENGGGPARWYPTSSAYPHDDVDVRGGIGSQIAIVDATSGRLLGSADSGRAPATLHAGAVHLHQGETYVVDELDLEAGVAFVHAEQPGWTTSARMVTSVEIDERTHEQVYGRVTAALAKVRVTRQVVGYLRTLPSGEVLDLIELDMPEQTLPTQAVFYTVTPRLLTAAGIEPRRVAGALHAAEHAAIGMLPLVASCDRWDVGGVSIAEHPDTGLPTVFVYDGHRGGAGFAERGFARVRTWLAATRAAIASCSCPQGCPSCVQSPKCGNGNSPLDKEGAAALLTAVLSDLPDEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H6A4</accession>
    <name>A0A231H6A4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein Mmr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mmr</name>
        <name evidence="8" type="ORF">B7C42_03873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000007">
        <property type="protein sequence ID" value="OXR44312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777673.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44312">
        <property type="protein sequence ID" value="OXR44312"/>
        <property type="gene ID" value="B7C42_03873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR44312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="107" mass="10933" checksum="CFCDA6F1AA2F1425" modified="2017-10-25" version="1">MMFLFLGLAIVTEVSATVSLKLSEGFTKLVPSIVVVVGYVAAFIFLSQALKRGMSVGVAYGVWSAIGVALVATIGVLFLDEPLTAVQIGGIALLIAGVLALELGGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H712</accession>
    <name>A0A231H712_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063065915.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44570">
        <property type="protein sequence ID" value="OXR44570"/>
        <property type="gene ID" value="B7C42_03360"/>
    </dbReference>
    <dbReference type="GeneID" id="66718705"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR44570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="70" mass="7782" checksum="FB3E1262CB2D9B8D" modified="2017-10-25" version="1">MAPVFDSCAVVPRHLTVEQAHNILHSHSSCPTDQCPRRKAALFFLMESRRSARGNGRDLRRPAPRTTGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H746</accession>
    <name>A0A231H746_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_03335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000006">
        <property type="protein sequence ID" value="OXR44546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44546">
        <property type="protein sequence ID" value="OXR44546"/>
        <property type="gene ID" value="B7C42_03335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="41"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="118"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR44546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="343" mass="37008" checksum="4B629B84AC61BD2F" modified="2017-10-25" version="1">MRLKPHATSVKLGIFTLVMVLVLALLVVIFSQMRFARENGYHAVFTSSSGMLPGSKVRIAGVPVGSVKSVKVGKDHLAHVDFDVDRQYKLYVSTQAAVRYENLVGDRYLELMDAPGTAQVLHSGATIGLDKTKPALDLDMLLGGFKPLLRGLDPQQVNSLTEALLQVFQGQGGTLVALLNSSGSFAKTLGDRDALIGSVIENLKTVLATIDDHNKDFDTTLTELQRLVSGLAADRDPIGAALPRLAGATGDLTDLLKQARPDLKATFDQLGRVADNLDQKSDDVEWVLQNLPSTYKELVRLGSYGSFLNMYVCGTNFLVDGPDGKPMHVNLPGLQTTGRCSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7C2</accession>
    <name>A0A231H7C2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome-partitioning ATPase Soj</fullName>
            <ecNumber evidence="3">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">soj_2</name>
        <name evidence="3" type="ORF">B7C42_02702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44748">
        <property type="protein sequence ID" value="OXR44748"/>
        <property type="gene ID" value="B7C42_02702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="77"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="356" mass="38387" checksum="4770C389367E2D14" modified="2017-10-25" version="1">MEGLGLVELRSETSSGQRTGSVEVVGPLGAAQPANAAADEDGFDWLGRTRAGRVLRLERPQRIWEAERAPGRSRPYVVATFNLKGGVGKTTTTAALAEILSAEFDKRVLLIDLDPQANLTAMMVGENRAMELDSGDGTLAAIFAAALAGRPAPDVRALIQHEVSPMHAVTTVDLLPASPKLIALQDEMPALRQGEPTAVLARALSGVLEDYDYVLVDCPPNLGPITQNGLRLSDGYLIPTIPDIMSTYGIPPVQAHLRHLAARWGDPLEELGVVVTKYRRSSAVHRTTLEILQANRTLPRLFPTRIPDSNQIAAAAAFTDFGSLRRKYGTGGQFLALRELTADFLATTRITLAWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7C9</accession>
    <name>A0A231H7C9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase FadD13</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784181.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44923">
        <property type="protein sequence ID" value="OXR44923"/>
        <property type="gene ID" value="B7C42_02879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="55"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="467"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR44923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="551" mass="59180" checksum="F3139587CBE6BC9D" modified="2017-10-25" version="1">MTTTSMPDIAAVMRELTGPGGRFELVEEEVLGARMPVLRHRRRAVAELLAASVAFGDRDYLVTEDRRLSYREHAAAAAALAAALHEEYGVGRGDRVAILAANTVEWVIAFWAAQSLGAIAVGLNGWWVPREIEYGLALTEPAVVVVDAKRAKLLADIDTPAAVVTMEEDLPRLIAAHAGAEPTVPDVAEDDPAVILFTSGTSGKPKAALHSQRNLLAVTGYFEYTDALAAAFTGKTPEPGAPLDLRCLLTSPLFHIASLHNLVVPRLATGSAVIMPQGGFDADRILRLIETERVTNWGAVPTMASRLLEHGDIGRYDTSSLTAFALASAPSSPAFKQRLREEVPFAADALVDSYGLTECSTAVAVATPADLAESPGTLGRPIISVALEIRDADGTPVPEGVEGEVYVRSPFVMLGYWRNPEATAAAIDAERWLRTGDFGVVEQGRLRLTGRRSDLILRGGENIYPVEIEQCLDEHPDVVECAVVGEPHPDLGQQVAAVVVLAEGSTASEADLRAFARERLAYFKVPERWRITSEPLPRNITGKLIRAGITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7G0</accession>
    <name>A0A231H7G0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysX_2</name>
        <name evidence="9" type="ORF">B7C42_02729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44775">
        <property type="protein sequence ID" value="OXR44775"/>
        <property type="gene ID" value="B7C42_02729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="133"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR44775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="457" mass="50972" checksum="AFEB3EC30C640DD4" modified="2017-10-25" version="1">MAELNSAVTGYRTYRHAALNPTRAVRVPLIVVLLLVGVVLLYAADRASREGVNRGWFVAVSLSGLFVARGLHLRRPITLPHFTVAVIVLGVSNIAYRSDHGTVGFVCLASTGLILMLPQSSRPQPDQRHRIAALVDRTVEDPLAPFALHSAKSYFFSADSNAAIGYRARFGIAVVAGDPVGNCAEFGRLIAEFSEFASARGWRIAVLGASPAVTELWRTRAADHHGLHAIPIGRDVVVEVDSFDMVGRKFRNLRQAVSRTRNFGVKTEVIPERELDREMRETLLGIVDEWGSGHQTRGFSMILDHLLDGRNPGMLVVIARDGEGRVAGFQRYGSSNHGSELSLDVPWRRKDAPNGLDERMIVDLVDYGRDNDVHRISLAFAAFPELFADKERSRSKQAIYVLARTLDPLIRLESLYRFLRKFNSFGNQRFVLIRWREIVFTALALLTLEFVPHRKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H7L1</accession>
    <name>A0A231H7L1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_02779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR44825">
        <property type="protein sequence ID" value="OXR44825"/>
        <property type="gene ID" value="B7C42_02779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012489086" evidence="1">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="188" mass="19531" checksum="888D67338A182031" modified="2017-10-25" version="1">MRGDQREASVIRKAATAVLAAAVVLVGGGCSSSTSGTASPETSDPKVATAALWDPCTLDSAAVAQMKVDPSTRKSDIAGQSSVEGFKKCTWHDTPWTYSVNVWSTVYTVDDYRKKEAGANFEPVTIGGRSGVKYDPADDSSGDQCFVQFPSGHGSFIVSVLRQDPSSAEAPCDRATAAAAAVVGALPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H823</accession>
    <name>A0A231H823_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_03041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45084">
        <property type="protein sequence ID" value="OXR45084"/>
        <property type="gene ID" value="B7C42_03041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="14406" checksum="36B095EA1A593207" modified="2017-10-25" version="1">MDPEDPLGEMRCAMVDIEITGTTVTVHVRGTHRLLSLCERVRFDLSHIVAVAPAEVDLRPPWMRAPGTFFPGVIAAGVFRGKGRKEFWDTRFDGRGVRIELTGTEFSRIVVDVEEPDEVRRMLARAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H8K9</accession>
    <name>A0A231H8K9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator BetI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betI_10</name>
        <name evidence="5" type="ORF">B7C42_03069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000005">
        <property type="protein sequence ID" value="OXR45112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45112">
        <property type="protein sequence ID" value="OXR45112"/>
        <property type="gene ID" value="B7C42_03069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="407" mass="44521" checksum="C0BCC890A55AACD8" modified="2017-10-25" version="1">MPATHNPERVIRRRPKNRRAQIASASAAAFGSLGYHGVSMEDIAARLGISSAALYRHYPSKYALFREELLRLSAAAVTAVTLPVEVQGHSAEARLGLVIDAIVADTIANRPTAALARWEARYLDRDDRRAFDERFETAISALRALIGELRPELARREGLVRAVAIFSVVSSIGDHHAHLPAKSLAGVLSEAAWSLIRTDLPVAADAPEPVRANDIPQSFKHQVLLNKAVELFHERGYPNVSVEEIAAAAQLSAASAVYRYYRSKDALLAAAFRRVADRMAAAIAPAVAASQTSEEALATLIDLYVAGSFAERELTFVYYAEFGNVGAYERTVLRNIQRLVVAEWVELLVDARPELARAQARILVHAGFGLVVGLGRLFGNNQQMCPRAHVVRLMEMTLFGRLATRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H953</accession>
    <name>A0A231H953_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_02486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45361">
        <property type="protein sequence ID" value="OXR45361"/>
        <property type="gene ID" value="B7C42_02486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010350">
        <property type="entry name" value="Aim32/Apd1-like_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030108">
        <property type="entry name" value="Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="PTHR31902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF10">
        <property type="entry name" value="PTHR31902:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035042">
        <property type="entry name" value="UCP035042_thirdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="319" mass="33421" checksum="B731BAB99A018568" modified="2017-10-25" version="1">MGADSRSAPPTSQAPAIDVEGLPCSAAAADIPLPGSATRVSGWLCVEQPGAWGRDVIGDAVLGAELTAELAARTKAARVRPTLIRRPGRGEFTGVRTVLLAASRPQGSWCERLTVTDPQQLLDIDLQVLNGPAPGIGERVTDPLTLVCAHGKRDQCCARLGRPIAARLAGDYPDQVWECSHTGGHRFAPAMVILPEGLTYGRVDGEDAVRAVAAVGRNALSLKGFRGRSGLSPVEQVAEIAVRERVPAALDQLTVTAVEPDTPISDPATFAGAAEVTHTDGRRWLVTTRTVGYPPRQASCGAAPKPASAIVADELRETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H965</accession>
    <name>A0A231H965_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PspC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_02495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45370">
        <property type="protein sequence ID" value="OXR45370"/>
        <property type="gene ID" value="B7C42_02495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="608" mass="61861" checksum="EB8074CBA4D73D08" modified="2017-10-25" version="1">MTTASGGTGGTSRTGFSEQLQHLWRTRPTRLPGQSPVAGVASGFGRRYGVDPVLIRVAFVVSTIFGGAGIVLYLAAWLLLPPAGDAVSPAEGLISRGHSSQSSTKTIVLIVALAIAVTTMGPVGVGLGGSGVISFALMVAGWWLLYMRQPEPPFDGSFPLTAEGGIAATGYPGASFPGGSPWSGSPYGPFTKLPDHYEPDPNGVAGSQVPAMPTQPTDDNASTATEPIGAATAPLRVDPVTVTPESPPDEARADSPDTASSADAATESIAAEGVPAEESRPAPSASEADPGTSEPGTSEPVAAESNSPSEEMAEDEMPADDRPTVAMTRPLPVESEAAAAPDERTAEDESDPDDSSGPGGSARPTPTPPPGPRPSGTRPIPDPAHIGPTPAGWDPLGVAPMAWDLPAPTQERPVAVVPAQRPRSRLTPVVIGLAVLAAAAAGAVAAAGADWMTPARIGAVALAVVGLGLIVGGFLRRGYGLMVVLAPLAGFVILASMVGPVEFDRGAMGDHVWTPATAADLASEYKITMGSGTLDLRQLPLTENRTVHVNVQMGDFRVLVPESMRLHATCNASMGDVSCPQGPTGPADGPILTLDIDVHAGNAEVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H971</accession>
    <name>A0A231H971_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ECF RNA polymerase sigma factor SigK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sigK_3</name>
        <name evidence="7" type="ORF">B7C42_02506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45381">
        <property type="protein sequence ID" value="OXR45381"/>
        <property type="gene ID" value="B7C42_02506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR45381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="196" mass="21669" checksum="3EEBDA37EC573B2E" modified="2017-10-25" version="1">MATPSVDSAITARASESIELAALLERCGRSDRQAFAELYDRTSARVFGLVLRVLHDSGYAEETTQEVYLQIWRTAANFDPAKGSAVTWLMTLAHRRAVDRVRAEQAHAQREVTYGAATLGNEFDEVTEEVGRRLEQQAVRESLATLTETQREAISLAYFGGRTYAEVATYLGVGLPTVKSRIRDGLTRLKKSLGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9F8</accession>
    <name>A0A231H9F8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784058.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45653">
        <property type="protein sequence ID" value="OXR45653"/>
        <property type="gene ID" value="B7C42_01945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="DUF4242"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="DUF4242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="84" mass="9176" checksum="14C827BADD8E5C07" modified="2017-10-25" version="1">MVLFIDVHEHLPEGTTAQDVAAAHAADQAIQGDYGVTYQRYWVDESSHTAFCLVDAPDADTAITVHREAHGLVPDRIYPVVEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9K8</accession>
    <name>A0A231H9K8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039776448.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45545">
        <property type="protein sequence ID" value="OXR45545"/>
        <property type="gene ID" value="B7C42_02670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="74" mass="8508" checksum="F76D6363E54C03A2" modified="2017-10-25" version="1">MAWTMRFPEDEGAELDAQAREEGRAKSEIVRDAVRMYLLAHRRWDVAFVDEEDTVDLGGPIRKEDIRGAMNRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9L8</accession>
    <name>A0A231H9L8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase fadE25</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B7C42_02005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45713">
        <property type="protein sequence ID" value="OXR45713"/>
        <property type="gene ID" value="B7C42_02005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="120"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="223"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR45713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="365" mass="40174" checksum="F5AE87774E4FC82A" modified="2017-10-25" version="1">MGITEIATFRDELRRWLADHDLAPGPDRTLDGQVAQLARVRRALFDAGWMRYGWPEQVGGLGGPAVLRAVLGEEVATRGLAEPGIYSMVEVLAPTMISYARPELAAAMVPALLSGREQWCQGFSEPGSGSDLASLSTKAVADGDTWIISGQKVWTSLAQYSARCVLLTRTAPGHQGISAFFVDTDSPGITVRPLRTMHGVDEFAEVYFDDVVVPGERMLGEPGDGWRVAMDLLPHERSTCFWHRIAYLFTRLDALIAETDLRDDAALGAAYLALHTVRCRSHATQRRLADGQPLGPETSIDKVLLATAEQQLFDTARDLLPGAVEFDDEEWRTEYLYSRAATIYGGTAEIQRNIIARRLLDLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H9Y4</accession>
    <name>A0A231H9Y4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039784075.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45665">
        <property type="protein sequence ID" value="OXR45665"/>
        <property type="gene ID" value="B7C42_01957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="82" mass="9490" checksum="707716DD58F7B734" modified="2017-10-25" version="1">MLTLAERARLSHGDVHVRIWLGRTAFDYRATVAAAVTLIHDCRRKRWCAIEVFLHGIEDALPETRLPNERLFLDPQPLRQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA13</accession>
    <name>A0A231HA13_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmC</name>
        <name evidence="6" type="ORF">B7C42_02672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000004">
        <property type="protein sequence ID" value="OXR45547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025347181.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45547">
        <property type="protein sequence ID" value="OXR45547"/>
        <property type="gene ID" value="B7C42_02672"/>
    </dbReference>
    <dbReference type="GeneID" id="66718919"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR45547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="79" mass="8967" checksum="2C7DAE8C7D226CA3" modified="2017-10-25" version="1">MATGTPAADLRELNEDELVARLRESKEELFNLRFQMATGQLQNNRRLRVVRHEIARIYTVMRERELGLASGPEGKGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HA19</accession>
    <name>A0A231HA19_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45586">
        <property type="protein sequence ID" value="OXR45586"/>
        <property type="gene ID" value="B7C42_01878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR45586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="315" mass="33740" checksum="CB61935DAC39F9CD" modified="2017-10-25" version="1">MSERSRDVSEALDVVRFFDALIAGGAGLDVLLRGAAVRAGTVAGFERNGRISRFAPTGQSVPGNNQGLRKLERSFDGGSVWLERDDDATRDKDELIVERLAFAVGLLATRGTGSAGLALVVDPTRSIDERMPGLVRLHIDPSTRIRLIATERGTALSGISAAVPTRYGLLQATLDITGQVTPAGPAGLGEWVRADHAPESWEGAVIAHRLTTSSTPVVDATALGAMTILARAHDPDSPHRDVKALARLDDHSAEVLQALCDAPSLRSAAVELSMHHSTLQAKHESLTRLLGYDLRTTAGRMRYIAAEFLRRLGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAC6</accession>
    <name>A0A231HAC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-succinoylsemialdehyde-pyridine dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ald_2</name>
        <name evidence="3" type="ORF">B7C42_02077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.83" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45785">
        <property type="protein sequence ID" value="OXR45785"/>
        <property type="gene ID" value="B7C42_02077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="13"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="477" mass="49668" checksum="E3324844AEA21EF3" modified="2017-10-25" version="1">MREYLTFYIGGRWVDPASTQTIEVTNPATEQVCGRVAAGSAEDVDRAVAAARTAFGTWPATTVADRLAVLQAVADEYQRRRDDLAAALTEEMGAPAALAGGFQVDLGAGHLDTAIAALAGYRFEQRQGASLVVKEPIGVCGLITPWNWPLNQIAVKVFPALATGCTVILKPSEQSPFTGQIFTEILDAAGVPAGVFNLVQGDGPGVGVPLSGHPDIDMISFTGSTRAGIDIARNAAPTVKRVTQELGGKSPNIVLDDADFAANVAKGVVTMMTNSGQTCSAGSRMLVPAARMDEAKDAARAAAGTVTVGDPTGEVAMGPVVSGAQFDKIQALIRKGIDEGATLVTGGTGRPDGLDVGFYVKPTVFADVGNDMTIAREEIFGPVLTILGYDSLDHAIEIANDTDYGLAGFVAGADLEQARAVARRIRAGSVAINDGFDFACPFGGYRKSGNGREWGAYGFEEYLETKAILGYAPEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAD5</accession>
    <name>A0A231HAD5_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_02217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778819.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45924">
        <property type="protein sequence ID" value="OXR45924"/>
        <property type="gene ID" value="B7C42_02217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="90"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR45924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="35857" checksum="0E0C67B9154341EA" modified="2017-10-25" version="1">MSISHFTSAIWLAFLIVVAAIALLYVLVQRRRKRHMLRFSNMETLEQVAPKRPSAWRHAPVALMLVGLALLTVAAAGPQAAKKVPRNRATVMLVIDVSLSMEATDVPPSRIQVAKKAATDFVDGLTPGINLGLVTFAGTASVQVSPTTNREAMKAAIQNMKLAERTATGEGIYSALQAIDTLASVLGGAQTPPPARIVLMSDGKQTVPDDKDVDNPRHGFVAARVAKQKSIPVSTISFGTTWGSVEIPDQDGKGSQRVRVPVDDDSLREIAKISGGDFYTASTLEELSAVYDTLDKQIGYEMQMGDASRPWLLLGLLLTAAGVVSGLVYRQRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HAT1</accession>
    <name>A0A231HAT1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ydjZ</name>
        <name evidence="5" type="ORF">B7C42_02254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000003">
        <property type="protein sequence ID" value="OXR45961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR45961">
        <property type="protein sequence ID" value="OXR45961"/>
        <property type="gene ID" value="B7C42_02254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325515" description="TVP38/TMEM64 family membrane protein" evidence="4">
        <location>
            <begin position="35"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR45961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="24169" checksum="4E66D7731A0D98CB" modified="2017-10-25" version="1">MALRLLRNRRVVMLAILATALVAVALLAPHPAPQQIRDWADSVGPVFPLLFFLVHALVTVAPFPRTVFTLSAGLLFGPILGITLAVAATTVSAVLALLLVRALDRDQVAARLTHPAVRAVDRRLARRGWLAVGSLRLIAPVPFSVINYCAGLSSVRMMPYLLATFVGIIPGTIGVVVLGDALTGKTNPGLLALSGVCITIGVIGLIVDARWGAEQFAAVTTEGAEEPAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HB82</accession>
    <name>A0A231HB82_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783277.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46203">
        <property type="protein sequence ID" value="OXR46203"/>
        <property type="gene ID" value="B7C42_01168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046288">
        <property type="entry name" value="DUF6325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19850">
        <property type="entry name" value="DUF6325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="150" mass="15697" checksum="680F704365936B9A" modified="2017-10-25" version="1">MTSAAGIDEMGPIDYLVIEFPAGRPPDGSALPVLRDLVGRGIIRVLNLAFLRKEGDGSLTGIDIADIGLECETSVALFAEETTGVLDDGDLREAGAALHPGRSAAVLIYENTWAAPLSVALRRNGAETVAAGRIPVEAILTTLDTLDDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBM6</accession>
    <name>A0A231HBM6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_01256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46290">
        <property type="protein sequence ID" value="OXR46290"/>
        <property type="gene ID" value="B7C42_01256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR46290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="158" mass="16116" checksum="4119E57493C55191" modified="2017-10-25" version="1">MLTTSAQVLAVLAVLTNAIVYGTDVAAALIFRPVYAKLDDATMTVSAGWGHYYGDRRMPFAGAGGVISTVLAVLVAAVAGATGAAVAAGIALLALLSWLGLYARIAKPINTAQTRAAMTGAIPADARALQDKWESILGYRVGLQALALAALCTTLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HBN3</accession>
    <name>A0A231HBN3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_01224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46258">
        <property type="protein sequence ID" value="OXR46258"/>
        <property type="gene ID" value="B7C42_01224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="76" mass="8024" checksum="0121E28441746A9F" modified="2017-10-25" version="1">MGMTELGFDAVSGLAGARWADPEVDIAPTAASTPLQRAAARLQAVLPPGWQVEIDLAAPRPHGDPQPVLRVRLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC57</accession>
    <name>A0A231HC57_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_01368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46402">
        <property type="protein sequence ID" value="OXR46402"/>
        <property type="gene ID" value="B7C42_01368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017518">
        <property type="entry name" value="CHP03084"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03084">
        <property type="entry name" value="TIGR03084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Wyosine_form" evidence="1">
        <location>
            <begin position="187"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR46402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="267" mass="28613" checksum="E9263EAE554B9C55" modified="2017-10-25" version="1">MLSVMADLEALLDDFEAECADLDRLVAPLDPAGWTRETPAPGWTIAHQIAHLTWTDEVSTIAATDAAAFAELLREATATIATFVDDAAAEVAGTPAPELLERWRRGRAGLAQALRAVPAGTKLPWFGPPMSPMSMVSARLMETWAHGQDVADALGVVRTPTARLRNIAHIGVRTRDFAYAVHGRQAPAEPFRVELTAPDGSIWSWGPEDAAQRVSGSASDFCLLVTQRRHRDDLPLVTTGSDAAEWLTIAQAFAGPPGSGREVGQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HC94</accession>
    <name>A0A231HC94_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chromosome-partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">parB</name>
        <name evidence="4" type="ORF">B7C42_01408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039781818.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46442">
        <property type="protein sequence ID" value="OXR46442"/>
        <property type="gene ID" value="B7C42_01408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="67"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR46442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="333" mass="36360" checksum="72A2B877E605772A" modified="2017-10-25" version="1">MSQAKKGGLGRGLAALIPTGPADVQGLGSAAANAVIGLDPIGPHPASAYLHRVPDAAEESGAGAVYREIPPDQIERNPKQPRQVFEEDALAELVHSVREFGLMQPIVVRVLESSPTPRYQLVMGERRWRACQEAGLETIPAIVRETTDDAMLRDALLENIHRVQLNPLEEAAAYQQLLEEFGVTHEELANRIGRSRPVVTNMIRLLKLPIPVQRRVAAGVLSAGHARALLGLEAGAEAQERLAERIVAEGLSVRATEEAVTLANRYPEDEVKPTPKRRQIYAPGLDKVAERLANSFDTRVTVSMGKKKGRIVVEFGSVDDLERIVGLMEQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD19</accession>
    <name>A0A231HD19_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS-type transporter EfpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efpA_2</name>
        <name evidence="7" type="ORF">B7C42_01568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46597">
        <property type="protein sequence ID" value="OXR46597"/>
        <property type="gene ID" value="B7C42_01568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXR46597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="492" mass="51462" checksum="B037B2DA23A9BFCF" modified="2017-10-25" version="1">MFRDMTSTATLPAASAADTRWPIRLWGMLITLCIVLFLDGLDVSMVGVALPSIGTELHLETSTLQWLVSGYVLGYGGLLLLGGRTADLLGRRKVFLIALAVFAVASLAGGLVSSGPLLIATRFVKGLAAAFTAPTGLSIITTNFAEGPARNKALSIYTVFGAGGYSMGLVFGGLMTGFGWRWTFLLPVPIALAALISAAILVPKDKGDTAEGGHDLLGALFSTAAMLLLVYTVVSAPQAGWGSARTVGSFAAVLVLFVAFVAVEKRVRHPLIRLGILRKATLVRASLVIVAVAGSYFSWQFIVTLYLQDSLGWSPLTLAMALLPVGVLVALSSVFSDKLVDRFGTGPIIAVTTTVMAIGYLLFLRIDTAPSYVAVILPAVLLIGIGWIGFPAINIQATNGIEDEEQGLAAGVLQTSMQVGAAIVLAITTALISSGPHGNSPQAVLDSYRPGLIFAGIAAIIGALIAFTHFLPTRRKQQEVEDIEQAPELAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD43</accession>
    <name>A0A231HD43_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B7C42_01812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46834">
        <property type="protein sequence ID" value="OXR46834"/>
        <property type="gene ID" value="B7C42_01812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="335" mass="35419" checksum="6D2C9A87B9859565" modified="2017-10-25" version="1">MANLGPGWFASVMATGIVSRAVGAAGWEWGGDALLIVGLIAYAVLVVATLLRIAFFRDRVIGDARNPATGFTYLAFVAATGVLSAGLSRHAWVGAALALLLVATVVWAVLGYAIPALLMLHHGAPTAVTGANGTWFLWVVGTQSLAVAATALPPPWGQRFAIPALLCWSVGVVLYGIVATVVLGTLFGTSLTAERLAPTYWIFMGATAISVLAGTQIMNQRSVALIATVRPMLEGATLVLWAFGSWLVPLLLAAGIWRHLVRHFGLSYEPGLWSIVFPVGMYGVGTAELGKATGEQWMVDFGHGEAWVALAVWAATAADLVITLIRRRRTREFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HD58</accession>
    <name>A0A231HD58_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative succinate-semialdehyde dehydrogenase [NADP(+)] 2</fullName>
            <ecNumber evidence="6">1.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gabD2_2</name>
        <name evidence="6" type="ORF">B7C42_01838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.79" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000002">
        <property type="protein sequence ID" value="OXR46860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46860">
        <property type="protein sequence ID" value="OXR46860"/>
        <property type="gene ID" value="B7C42_01838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="45"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR46860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="541" mass="58106" checksum="E7F832534FF057C4" modified="2017-10-25" version="1">METTTHSGAEATSHSGAASTLPPRITTTLIDRLTGLITAGTAGEKREPYDMIEVYTGAVVGELPQSSPEDVAAAADKARAAQREWANWPVKRRLQVFEKAHELILSDLDTIADLIQIGCGKTRRMAIEESCDPVMVISHYLKHAERILKPIRRGGAMPIISTSTEQHRPKGVVAVIAPWNFPFAISISDSIPALIAGNGVVIKPDNKTALCTLYGVELLRKAGLPRDLIQVVCGTGPDVGPTLIDHSDFVMFTGSTATGRTIGERAGRNLISCSLELGGKNPMIVLEDANLDEVIPGAIFAVYGNSGQACMHIERIYVHDRVHDEFVRRFVAAAEELGSKAGASYTADPEFGSLVSVDHMRRVAAHVDDAVAKGATVLTGGKARPDIGPAFYEPTVLTGVTPEMEHATVETFGPVVTVYRYTDENEAVRLANATTYGLNASIWSSDLARAEKLADRLEAGNVNVNDGFVATYSAKMTPSGGVKQSGVGTRHGDAGLLKYTDTVNVGVQKKQVLSARAGMPFEKQLKSTLLTLRLSRRLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE20</accession>
    <name>A0A231HE20_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR46995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR46995">
        <property type="protein sequence ID" value="OXR46995"/>
        <property type="gene ID" value="B7C42_00111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR46995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="105" mass="10997" checksum="97B84EEAE563C6A5" modified="2017-10-25" version="1">MSDYSPIETVALADKVAELRAAWKAGQPLTGGQVFGLPALDGDVWVDTAGATVITGAAPKTITSYLSRGKPKSNPFPAPSKFLGRNYWPASALLDWAATQPADGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HE32</accession>
    <name>A0A231HE32_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ORF">B7C42_00355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777088.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47233">
        <property type="protein sequence ID" value="OXR47233"/>
        <property type="gene ID" value="B7C42_00355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="13"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXR47233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="422" mass="43986" checksum="8646B261F2F4C993" modified="2017-10-25" version="1">MTAGTVGEVDTVREAVHEAARRARVASRTLAQLTTAQKDAALHAAADALLAHKDAVLAANAEDIATAEAGGTAASLLDRLRLTEPRIDGIASGLRQVAGLPDPVGAVLRGSTLANGLEIRQVRVPLGVVGMVYEARPNVTVDAFGLALKSGNAALLRGSSSAARSNAALVEVMREALVAQGLPADAVQLLPSEDRSSVTHLIQARGLVDVVIPRGGAGLINAVVRDAQVPTIETGTGNCHVYVHAAADLEMAESILLNSKTRRPSVCNTAETVLIDRAIAETAVPRLIGALEQAQVTIHGDLPGLVPATDEDWADEYLSLDIALKVVDDLDAAVDHINEWGTGHTEAIVTADLKAAREFTARVDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMALPELTSTKWIVWGDGQIRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEC6</accession>
    <name>A0A231HEC6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional repressor SmtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smtB_2</name>
        <name evidence="3" type="ORF">B7C42_00422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47300">
        <property type="protein sequence ID" value="OXR47300"/>
        <property type="gene ID" value="B7C42_00422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="14132" checksum="34BF15A04A0444D2" modified="2017-10-25" version="1">MTADSGVPARRSRVAVEAPTPIPHDPYPYRAPTAPAVPARTTLDNAGELLRALAAPVRIAIVLQLRESPRCVHELVDTLGVTQPLVSQHLRILKSAGVVRGERTGREVIYELVDDHLARIVVDAVAHAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEG8</accession>
    <name>A0A231HEG8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_00209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47087">
        <property type="protein sequence ID" value="OXR47087"/>
        <property type="gene ID" value="B7C42_00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR47087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="156" mass="16861" checksum="33EC42AA8CE67F6B" modified="2017-10-25" version="1">MRTRARAISFGGQYDVDAQALKVVVHRAVPVGACASDGAWTREDDAPDIWVLFQVGKQSSKYGATPQACCGRADLDEFLHDAKLVLSRSAEPCFTLELNADRLTACRPICFGHGSYGQEHHGWHEACVVEGSILRSHAALPLGLPGTAEPVWSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HEN1</accession>
    <name>A0A231HEN1_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ilvD_1</name>
        <name evidence="15" type="synonym">ilvD</name>
        <name evidence="16" type="ORF">B7C42_00523</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNM20130759</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47400">
        <property type="protein sequence ID" value="OXR47400"/>
        <property type="gene ID" value="B7C42_00523"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXR47400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="613" mass="64484" checksum="13C94E53ADAFC2F6" modified="2017-10-25" version="1">MPPLRSRTTTAGRNAAGARALWRATGLTDSDFGKPIVAIANSYTQFVPGHVHLKDVGEIVADAVRAAGGVPREFHTIAVDDGIAMGHGGMLYSLPSREIIADSVEYMVNAHTADALVCISNCDKITPGMLNAAMRLNIPTVFVSGGPMEAGKAVVVGGVAQAPTDLITAIAASASTEVSDEGLSEVERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHAARRALFERAGSTVVDIANRWYREDDDSVLPRNVANAKAFRNAMALDVAMGGSTNTVLHTLAAAQEGEIDFDLATIDEISRRVPCLSKVSPNSDYHMEDVHRAGGIPAILGELRRGGLLETDVTTVHTASFDEWLDTWDIRSGKASDEAIELFHAAPGGVRTTVPFSTENRWSSLDTDAEGGCIRDIAHAYTVEGGLCVLRGNIALDGAILKTAGIDEDLFTFEGPAVVLESQEDAVSAILGKKITPGDVVVIRYEGPAGGPGMQEMLHPTSFLKGLGLGKVCALITDGRFSGGTSGLSIGHISPEAASGGAIGLIENGDRIRIDVHTRALELLVDDEVLAERRAKMEARERPWQPVQRDRPITTALRAYAALATSADKGAVRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HER0</accession>
    <name>A0A231HER0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein ScoF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scoF_1</name>
        <name evidence="4" type="ORF">B7C42_00566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025351824.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47443">
        <property type="protein sequence ID" value="OXR47443"/>
        <property type="gene ID" value="B7C42_00566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR47443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="67" mass="7192" checksum="2EFB2B35451C6EA0" modified="2017-10-25" version="1">MAQGVVKWFNSEKGFGFIAQDDGGPDVFVHYSAVSGSGFRSLDEGQRVEFEIGQGQKGPQAQNVSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFF9</accession>
    <name>A0A231HFF9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47437">
        <property type="protein sequence ID" value="OXR47437"/>
        <property type="gene ID" value="B7C42_00560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="163" mass="18006" checksum="0FBEF312936C944E" modified="2017-10-25" version="1">MVVGKRGRAPIDSPGFELPLLLFAGFRSLIDELHAELARQGHPDMRPAHGFAMQAIGVQGATASDIGRKLGVSKQAAGKTVERLTALGYAERVEDPEDARRKIVRLTPHGIDALRQSAEIFERLRRRWVKELGAQRVRDVESALRTMVPPESFRLDVAGWFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFJ8</accession>
    <name>A0A231HFJ8_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47609">
        <property type="protein sequence ID" value="OXR47609"/>
        <property type="gene ID" value="B7C42_00734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="99"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="378" mass="41995" checksum="8C045FE95DA3D221" modified="2017-10-25" version="1">MRLPAVHFNLILPLTMPVSETVTHARSARLAVQAPERVEYREAVTNETPLAPSTTHAWQPDVLGEGYRQLTIPLGPDPDGEGVVDATLVRHEPDIAEPAAGAVLYVHGFTDYFFQKHLAEHMSARGYRFYALDLRKCGRSRRPGQTAHYVSDLRLYDAELDRAVQIVREETGLPVLLMAHSTGGLVLPLWLNRRDAAAEGITGLVLNSPWFDLQGPAYYRHIGTAVIGGVGRVRAMTRLPGGELSTYGDSLHTSVSGEWDYNLDWKPLGGFPVHLGWLRAIRRGHAELHRGLDVGVPALILRSKVTKFMRKYGPAADVSDVVLDVRQIQRWSGCLGGRTNIVPIEGARHDVFLSAPEVRSHAFTELDAWLSWLRDFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFN0</accession>
    <name>A0A231HFN0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_00908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47783">
        <property type="protein sequence ID" value="OXR47783"/>
        <property type="gene ID" value="B7C42_00908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR47783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="46" mass="4988" checksum="1428DBE2A2798B72" modified="2017-10-25" version="1">MNVSITASHRRRRATSNEPEDVRSAVLVLMVWAALIVAAGVLLISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFS7</accession>
    <name>A0A231HFS7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47535">
        <property type="protein sequence ID" value="OXR47535"/>
        <property type="gene ID" value="B7C42_00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR47535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="435" mass="49256" checksum="9858285377C08B4B" modified="2017-10-25" version="1">MSERLYQLVHRDPTREQAEGSADPGEEGAFTGEGEAIVELGALGGGRRLGRGCRRRLSCGCRRRLGRRRTRRLGRMRTRRLGRMRTRRLGRRRTRRLGRRRTRRLGRRRTRRLGRRRTRRLGRRRTRRLGRRRTRRLGRRRTRRLGRAGRRRLDIAAGGRARTAAARVRRCGFGGAGRFGTHEPDLLRARGGRGDGAETRTATCLSTGRIVPANDAAVIESATSRHTIIDLPFHGASPADLGHSVLPERALFTCFRVVHTRRNRSFHVPRFRRGWDACAGCRHFSWGRRWWPRPAAPPRQRPRPRPDSAGRCSRVRPSCVVSTNRPTIGYRAIAESISPAPPGRRYSPPAPESWCSRVRWAANRSSRSTIRAGCARPTSRCERMCRSAAESSADRRWGRCNPDMWAAPASACIGVCGAAVTIWTPSAWCATHPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231HFZ3</accession>
    <name>A0A231HFZ3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B7C42_00884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNM20130759</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000001">
        <property type="protein sequence ID" value="OXR47759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR47759">
        <property type="protein sequence ID" value="OXR47759"/>
        <property type="gene ID" value="B7C42_00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXR47759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="124" mass="14087" checksum="9C52B4D8F811C771" modified="2017-10-25" version="1">MPVWDVFWLIIMSFAFAAYLVLLFWIFTDLFRDRDTSGWVKAVWVVFLFVLPLLTSLVYLIVRGRGMAQRSARAAKEAEQAQHAYIKDVAGTNSATQIADAKRLLDEGTITAQEFEQLKSRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSK3</accession>
    <name>A0A231GSK3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000261">
        <property type="protein sequence ID" value="OXR39586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39586">
        <property type="protein sequence ID" value="OXR39586"/>
        <property type="gene ID" value="B7C42_08346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="44" mass="4647" checksum="45155113D51B3BE7" modified="2017-10-25" version="1">MLSLFREIRRSGGAPIMPDVARVLGRAPRDPAVWIGEQGASAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSK4</accession>
    <name>A0A231GSK4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000171">
        <property type="protein sequence ID" value="OXR39603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39603">
        <property type="protein sequence ID" value="OXR39603"/>
        <property type="gene ID" value="B7C42_08329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="52" mass="5770" checksum="9EC7E50962FDED04" modified="2017-10-25" version="1">MVLEFADRVGQYQRAGHRPLLDTLGALPADDRVFDHTPDAIAYARTRLTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GSX0</accession>
    <name>A0A231GSX0_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_08218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000081">
        <property type="protein sequence ID" value="OXR39716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39716">
        <property type="protein sequence ID" value="OXR39716"/>
        <property type="gene ID" value="B7C42_08218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR39716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="91" mass="10515" checksum="8A632C837AA4264B" modified="2017-10-25" version="1">MPMTQGRYGDSTEHHRLFWIGHNAGQLLRSLRRDPRDGGDGYTMHREFGAWVLRPVSGWRSLRWITPPVDKVRSVQDRDAAADYYAAKFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTG8</accession>
    <name>A0A231GTG8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase SadH</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sadH_8</name>
        <name evidence="2" type="ORF">B7C42_08156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000068">
        <property type="protein sequence ID" value="OXR39771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39771">
        <property type="protein sequence ID" value="OXR39771"/>
        <property type="gene ID" value="B7C42_08156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR39771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="272" mass="28694" checksum="47973F056F1C57D8" modified="2017-10-25" version="1">MRNYRGRVVVITGAGSGIGQALAVQLADHGARLALSDINEESVAATAAECARRGADVAHFGLDVSDRDAVYAHAATVAEHFGVVHLVINNAGVAVHAGIQDMSDEDMAWIMDINFWGVVHGTRAFLPHLIASGHGQLANVSSLFGLIAAPKDSAYNASKFAVRGFTESIRQELRIERRPVSVSCIHPGGIKTAIARTARVAAGDDPAAVTALFDRVALTTPESAARTIISGLRRERSRILVGPDAWLIAALPRLLGAHYSLAVETGARLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTQ7</accession>
    <name>A0A231GTQ7_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DegU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degU_6</name>
        <name evidence="5" type="ORF">B7C42_07951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000048">
        <property type="protein sequence ID" value="OXR39972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR39972">
        <property type="protein sequence ID" value="OXR39972"/>
        <property type="gene ID" value="B7C42_07951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="330"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR39972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="395" mass="43925" checksum="D6585EF355AF06DC" modified="2017-10-25" version="1">MAVAMASDYTGVSPTGRVRQGWRRREGEIAARLAVLRDAVFDAVGAAAPLPRVEWDGPWRSAEVVSNLIHFCIARLRNVRSSDTASAERLCALILELQQLALDLYLHDTGERSQRLAECAAGLSRLRSLRDTTALLDVACEEIVLRCGFQRVVLSRVEGRSWRPSMAHFAAERESESWFADWINESIPLDSRSPEAQLLAKRRPSLVYDTSNAPVYRPIIVDAGRSRSYVVAPIVHGDDVVGFVHADHHPLTRRADEGDRDVLWAFTDGFSHIYERTVLLEQLREQRDQVRDLIVSAVNRMDDLCEADISIVGAGDFEDRESALIVSGAAYGNMGDLTEREADVFRLMVAGATNRAIAERLIISEGTVKSHVKHILRKFGAANRAQAIAWSLQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GTW5</accession>
    <name>A0A231GTW5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan endopeptidase RipA</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ripA_5</name>
        <name evidence="5" type="ORF">B7C42_07902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000045">
        <property type="protein sequence ID" value="OXR40018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40018">
        <property type="protein sequence ID" value="OXR40018"/>
        <property type="gene ID" value="B7C42_07902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="224"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="375" mass="38979" checksum="CE5DAC5F35976C79" modified="2017-10-25" version="1">MSPTRTILAGIVALPIALILFLAVLVGIQPADWCATQVLAGGVEGPTGQSLAGLNERQLELARNGVAIGKQRRAPESVIIAELAAMITESTLRNLANSNLPESLSFPNDGVGADHDSVGPHQMRVSVWGRVGIATLMNAAYQINWFYDQAATITSAASMTSAELAQAVEVSAPNAYAGQLDLARRLYAMFADIDPGALPAAEPGQSPTGCGPEAGSPGEPVPASGFGQAVVAAAQQWIGTPYVWGGGDANGPTGGGFDCSGLTLYAISQASRGRIRLPHYTQAQQDSPAGQSVPFDQRQPGDLIFFTTAGESDSHHVAVYAGRDPDGTDLVIHAPQTGQTVTTAPLARVAGSDHLDVRRYTAPPPNPTLEEGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GU78</accession>
    <name>A0A231GU78_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside triphosphatase NudI</fullName>
            <ecNumber evidence="6">3.6.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nudI_1</name>
        <name evidence="6" type="ORF">B7C42_07850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="6"/>
    <dbReference type="EMBL" id="NGAF01000042">
        <property type="protein sequence ID" value="OXR40095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40095">
        <property type="protein sequence ID" value="OXR40095"/>
        <property type="gene ID" value="B7C42_07850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR40095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="157" mass="17514" checksum="08E8F6B9CB4C528C" modified="2017-10-25" version="1">MGSRRDYYRDPDAPTPNSLVPGGSALVVDTDGSILMQRRSDSGNWSLPGGVMEIGETLEQCVVRETREESGLDIEITGLLGIYTDPAHVIAYEDGEVRQEFNITYYGRVVGGRIAVSAESTEVRFIRPDELPEIPVHDTVRLRLKHHTEQRTQPYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVD9</accession>
    <name>A0A231GVD9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Osmoprotectant import ATP-binding protein OsmV</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">osmV</name>
        <name evidence="5" type="ORF">B7C42_07367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40558">
        <property type="protein sequence ID" value="OXR40558"/>
        <property type="gene ID" value="B7C42_07367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXR40558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="396" mass="42510" checksum="1D6CBE4FF0CBE0A8" modified="2017-10-25" version="1">MTDTATADRTDHEPAEIVLDAVSKHYPGQRDPAVDRISLTIPAGEIVVFVGPSGCGKTTTMRMINRLIEPTSGTITIAGRDVTAVNPDRLRRQIGYSIQQAGLFPHMTVARNIATVPGLLGWDRARVRARVDEMLNLVGLDPETFRGRYPRRLSGGQQQRVGVARALAADPPVLLMDEPFGAVDPITRGLLQDELLRLQTELHKTIVFVTHDFNEAVKLGDRIAVLGNSSRVLQYDTPAAILAGPADETVAGFVGADAALKQLTLVRIADVELGGCATAAQDDPVDTLRAALATQEWKWGLILDSDRRPLRWVSEHQLAQAQSLHDAGIPVTGTVTADSTLQAALETLLAESTANAVVTGARGEYAGLVAIDTLVAHLSRTRTEHRSATADSGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GVG2</accession>
    <name>A0A231GVG2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidoglycan hydrolase</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000030">
        <property type="protein sequence ID" value="OXR40562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40562">
        <property type="protein sequence ID" value="OXR40562"/>
        <property type="gene ID" value="B7C42_07371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012443783" evidence="1">
        <location>
            <begin position="39"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="243" mass="25351" checksum="A64E932F2CB49E89" modified="2017-10-25" version="1">MRSVPMTRRTLFGYAGAAATAAGLAALTPAVLAPPAAADNVLGTLLDYAGGVPDAAAIRAAGHAGAIRYVSDRRPGAEWMTGKPLRASEVDALHAAGLTVVSCYQFGKGATADWKGGLEAGKRHADRGLQLHRDAGGPDGVPIYASIDDNPTPVDFATLIAPYLAGWESVLGNENVGVYANAPTIELAKVAGLGSWYWQHNWGTPKGFVHPAANLHQIEIDDRTVDGVGVDVNTILTAQYGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW14</accession>
    <name>A0A231GW14_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000027">
        <property type="protein sequence ID" value="OXR40762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782946.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40762">
        <property type="protein sequence ID" value="OXR40762"/>
        <property type="gene ID" value="B7C42_07186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="114"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="390" mass="42962" checksum="D5B65D6E8C1D3334" modified="2017-10-25" version="1">MNHKLWLLGRSVTVGTRMLGEKIRGPRSRSLTDVPISGDHVTPEWLTAVLCRDVPGAEVTDFETANGSSGTSTRVAIRVEYNEAGTQAQLPTRLFAKTTTSFSQRILLGGGKMIDGETRFFRDFRPAVDIEAPIGYWGASDPASWRSIALMEDIAATRGAVFSEPTASITRDQAEDLVRNLARLHGTFWESEAIDALNTPAYMLDVYLSAIDMKKRCEVGLRRAEEVVPPALHGSSERLWAGVERAVAIATEEVPPTLLHGDPHIGQTYVTSAGRMGFVDWQVVMRGGWAHDFAYTVNSGCEPEDRRVWDKDLLAAYLDELGEAGGKPPAFDDAWLLYRQQSMFAYAAWAFTIGRASYQPKMQSNETCLTLLRRITTAIDDNDSLGALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GW68</accession>
    <name>A0A231GW68_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_07008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000025">
        <property type="protein sequence ID" value="OXR40873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40873">
        <property type="protein sequence ID" value="OXR40873"/>
        <property type="gene ID" value="B7C42_07008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="135" mass="14648" checksum="0F0BE86A247E7E62" modified="2017-10-25" version="1">MQHEGYRQTAEQVEPATGTGDQNPLTVLKAMEQRCVEQRGGNHSSKYSAHPPMGSRVDLPLRRTRLADGLVVPGHESYDPEGFGRFMTLAVSGRIRCNPVSGETPGGSEPYSVSCQMVLSAVGVKQVLSRHGTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWK3</accession>
    <name>A0A231GWK3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40962">
        <property type="protein sequence ID" value="OXR40962"/>
        <property type="gene ID" value="B7C42_06928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR40962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="242" mass="25117" checksum="CDB768235329291C" modified="2017-10-25" version="1">MPELPRSGGPRPAVVVALPGTGSDADFARRAFEPACAARDLPFRAVEPDPLAVVASCRAALDEAARTGPVLAAGISLGAAIAVEWAGAHPESAFGVVAALPAWTGSDIAGCPAALSAATTAAQLRADGLEPVIERMRAGSPAWLGRALTQSWRTHWPDLPSALEEAATYAWPDAELLAALRVPTIIVGAIDDPVHPLIVAEQWYELIPQARIHRITLDELGADPGILGARGIPGLIAPRLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWP5</accession>
    <name>A0A231GWP5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41047">
        <property type="protein sequence ID" value="OXR41047"/>
        <property type="gene ID" value="B7C42_06817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="186" mass="19854" checksum="BB2176EEB2F9CDE7" modified="2017-10-25" version="1">MLESSASPVYTRRARRAPVFEPPLDPRSSGGATAGKSLDRRTSAPVVPRLRTPRRSAHDGRSPGSGAGVPMSSGMCGGNEIGTAAAQFAERSLRLVLEVIDGRRPLGQLRPVVEPTVLAAVETLARTAAAERRLGTAVLVTVKLAEVTASAAEVCGGYERGQRRFAVAARLVLRRGRWRMSALRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWR6</accession>
    <name>A0A231GWR6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YybR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yybR_4</name>
        <name evidence="2" type="ORF">B7C42_06823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41053">
        <property type="protein sequence ID" value="OXR41053"/>
        <property type="gene ID" value="B7C42_06823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="228" mass="25823" checksum="6B3CA70B23128FA4" modified="2017-10-25" version="1">MSGYGEFCPIAKAMDVLDERWALLVVRELLLGSTHFNELRRGNPKMSPALLSRRLRSLERSGVLRREIGVDGRAAYILTDAGRELSTVVEALGAWGVRWIGDLGDRDLDPHLLLWDIRRTIPIREWPDERTVLAVEFTDVPGKEAHWWLLVERGTAAICDYDPGFEVAATVRSTLRQFTEIWRGDRSWATALRDETTQIVAPASIRRQVPQWIGQASLAATPRPERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWV5</accession>
    <name>A0A231GWV5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase Pat</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000024">
        <property type="protein sequence ID" value="OXR40991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR40991">
        <property type="protein sequence ID" value="OXR40991"/>
        <property type="gene ID" value="B7C42_06957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR40991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="899" mass="95492" checksum="15D56F86523FE6A2" modified="2017-10-25" version="1">MTESSAPAPDAENTPADPPPPPQHWFADVLAADGGVVRLRPITPDDAEPMQAFHAALSDRTRYLRYFGPYPRMTPKDLYRTTHVDYHNRVGLVVELGSVIIAVGRYELLTDREGPRAAEVAFVVADEHQGRGLGSILLEHLAGAAAENDIETFVAEVLAENHTMVTVFREAGYQVQRSRDGSVLHLEFAIDPTEALLSVRDSRERASEARSVGNLLAPRSIAVIGATPAASRVGGAVLANLLSGVFQGPVYPVNPNRSSVRGVRAYPTVHDIPDELDLAVVAVPAEEIKSVLDDCMAKGVKGLVVLTAGFSETGPAGFHAERDLVDAARGHGMRVVGPSALGIANSDPAVSLNATLAPVLPGRGRVGFFCQSGPLGAAILAEAAARKLGLSTFVSAGNRADVSGNDLLQYWDTDPDTDVVLLYLETFGNPRKFSRIARRVARTKPVVAVSSGRNAANVPVSGLERSVERDLFAQAGIVQVDTIAELFDCAMLLAYQPLPDGPRLAVIGNSAALGWLAVDAARGEGLEVGEPTDLGPQAEPADYLTAVASAMDSAEVDAVIVIFAPPVPTAVTAFAEAIRAGAQDAAKPVLTTFVADHGMPNLLTVRGAGGIVDRGSIPSYPDPERAARALARVRRYAAWRTRPASLVVRPDGLEVGRARELVERWMTRSPDGDWLGDLEAAELLACYGIRVVDFREARDPDAAVAAAAELGYPVAAKATGEMWRSRPDFTGVRLDLWRDTAVRRAYTDLAELTGNAVVHIQKMATKGVGCVLRVQDDPSFGSVIGFGLSGTIIDLLGDRAYRALPLTQAEALELIDAPRAAPLLDGQAGPGRTIGEPVDKKALAVLAQRISALCDDLPEVRELSVEPVLASPEGAAILYVRVRIGPEPSRFDNGPRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWV9</accession>
    <name>A0A231GWV9_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41107">
        <property type="protein sequence ID" value="OXR41107"/>
        <property type="gene ID" value="B7C42_06877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="88" mass="9670" checksum="56C627D49FF7E140" modified="2017-10-25" version="1">MTSVPVDPHVTAIRPVAPRTPQGCEECLRLGTPWVHLRLCLTCGHVGCCDSSPGKHASAHAHTVGHPIVQSMEPGEDWRWCYVDQNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GWY4</accession>
    <name>A0A231GWY4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000023">
        <property type="protein sequence ID" value="OXR41109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41109">
        <property type="protein sequence ID" value="OXR41109"/>
        <property type="gene ID" value="B7C42_06879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015207">
        <property type="entry name" value="DUF1931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09123">
        <property type="entry name" value="DUF1931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16819" checksum="953672165CCEA56A" modified="2017-10-25" version="1">MPVMGTVKFQQLFRAAAGLQVDRNDLKRYTDFIDDKIYDLILIGKSSAKANLRDVIEPWDLPITKGLQESIHRFEKLDQEIELQALLDQLTARPPLDMALSEATEQRLPLVAGGLSVALAHTFVTIEPDRKNPGTAEWHVAFDIFHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX10</accession>
    <name>A0A231GX10_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycothiol acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshD_8</name>
        <name evidence="3" type="ORF">B7C42_06750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="3"/>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783031.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41154">
        <property type="protein sequence ID" value="OXR41154"/>
        <property type="gene ID" value="B7C42_06750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="184" mass="19996" checksum="1671F18EBC4DA94E" modified="2017-10-25" version="1">MDSDAVIVPMGLGHLRQVLDLGHEVFDTDVKPYTSWSLTSVAEHLDSADNACWVALDSDRVVGFVLGSMEFELRDDWGYLEWIAVAPDMQGRGLARRLVDICSEALFARGARRIVTDVEQSNTASATLMTRSGFSPAASVTLFVRPNPAEPEPDSEAPLPPIAPGAKRALIRRGRLAGDNRGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GX82</accession>
    <name>A0A231GX82_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_06778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000022">
        <property type="protein sequence ID" value="OXR41182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039782452.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41182">
        <property type="protein sequence ID" value="OXR41182"/>
        <property type="gene ID" value="B7C42_06778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011267691" evidence="2">
        <location>
            <begin position="29"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR41182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="193" mass="18788" checksum="309B3B8294CB4332" modified="2017-10-25" version="1">MSFLGLSLKDVVVGAVSAIPVVGAVAGAATDGIWTGIETGSVTDGLKAAAITGALAAVPGGKIGSMFGEKLLAKGLLGKGVGLIGKIPLKTVKNVAARGGGKGLQRSLGRAVLRGAGGTLGSAIYNPEADAGAPKIKAIPVRPAGADLAGNSFRDSPAATLNYQGGTVAQQPTTTTGITEQPAPDATPRAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GXX5</accession>
    <name>A0A231GXX5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_06571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000020">
        <property type="protein sequence ID" value="OXR41428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41428">
        <property type="protein sequence ID" value="OXR41428"/>
        <property type="gene ID" value="B7C42_06571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR41428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="131" mass="14350" checksum="B1F07B00D602C6B8" modified="2017-10-25" version="1">MAQRLAAAAELLDGTVTDAGGLWSRATVWILRIALEQSVDGLWARVSPPLARCSMRAQLLALDSCAGPELAGRVGGLWATLSRAGHHLDSEPAPTLHELRDWFDETARLAEELDRIDRADVPAVFGRRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GY85</accession>
    <name>A0A231GY85_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlaE_20</name>
        <name evidence="2" type="ORF">B7C42_06383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000019">
        <property type="protein sequence ID" value="OXR41491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41491">
        <property type="protein sequence ID" value="OXR41491"/>
        <property type="gene ID" value="B7C42_06383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="30250" checksum="9959DF59E8673B5E" modified="2017-10-25" version="1">MTATPYAPAGLRWVHRLGRRAHPLRPFESIGFVLGFGWQVVSSLPYTLRHYRRQTVVVITDMTWGRGSVIIGGGVVPLMLLLGAAMGASIGIEAFSALNLLSLGQLSGLISAFGVTRELAPIAAGVGFAAQAGCRMTAEIGSMRISEEIDALESLGVRSVPFVVTTRVIAGIIAVAPAFVVALILAYLSCALIVTTIHGTPAGTYNHYFDQFVLGWDVIAATIKVMVFAVAVVLIHCYQGFFATGGPEGVGIGSGRAIRASLVSIIALDMLTTIVLWGFQSPITFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYD2</accession>
    <name>A0A231GYD2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783629.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41606">
        <property type="protein sequence ID" value="OXR41606"/>
        <property type="gene ID" value="B7C42_06247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="206" mass="21316" checksum="80148AFCEDF3F0F9" modified="2017-10-25" version="1">MLLRRLSALYTGLWLYGFSMAVMIRAALGLDPWDVFHQGVAAHVPVSFGTVTAATGIAVLLAWIPLRQRPGLGTVSNVVVLAVSVDAGLWLLPELDAMAVRIAAMAAAVVLNAIATVLYIGAGMGPGPRDGLMTGLVARTGKPVWVIRTGIEATVLGTGWLLGGSVGVGTFVYAFGIGPLIQLLIPLVDRVVPGFRAGTAPEPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYF3</accession>
    <name>A0A231GYF3_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039778321.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41628">
        <property type="protein sequence ID" value="OXR41628"/>
        <property type="gene ID" value="B7C42_06269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="129" mass="14023" checksum="E827987B5D117AA4" modified="2017-10-25" version="1">MTWNELAQQKYVLLTTYKKDGTPVGAPVWVAPDGDRLVVWTNPKTWKVKRLRRNAAVTVQACDARGRTSGSPVSAGTARILDADGTERVRDLIAHKYGVIGTVLIRGHKLIFGKDRSVGLAITAEPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GYK8</accession>
    <name>A0A231GYK8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_06321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000018">
        <property type="protein sequence ID" value="OXR41680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039783120.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR41680">
        <property type="protein sequence ID" value="OXR41680"/>
        <property type="gene ID" value="B7C42_06321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR41680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="236" mass="24967" checksum="C9D19522D1F8750A" modified="2017-10-25" version="1">MLGHSHATSGALAWAGAAAALPLSILTFPAAQIGHLGTVDLLMGTFLTAGAALLPDADHPSGTISHALGPITHTACKIISTVSGGHRHATHSLAFVAAIAYGTWAGEHWIGRWFTLGLVFFLLALAVRALNLCPPGEGLRSYATIAVLAVAGTFAMDQWISDKPAWLPFSVGLGALAHLIGDCLTDRGCRLFWPLDIRTRIPIIDRTGNKVETWVISPLFVLGTLAALWYVITHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZR2</accession>
    <name>A0A231GZR2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator PuuR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">puuR</name>
        <name evidence="3" type="ORF">B7C42_05688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063821371.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42089">
        <property type="protein sequence ID" value="OXR42089"/>
        <property type="gene ID" value="B7C42_05688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR42089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="250" mass="26688" checksum="A4FA36DF1E939852" modified="2017-10-25" version="1">MQDRIGQALKQARLDRGLSLRALAAAAGISASQLSQIENNKSQPSVSTLYALVNRLEVSLDELLGISYGRTASGAEPAPESSTGTTRPGGVVQRAADNPVLEMANGVRWERLAVGPGSGADALLVTYEPGAASSVDRMPMRHSGTEYAYLFTGELTLLLDFDKYTVSAGDSLCFDSTRPHMYVNQSDQRASGVWFVTGRHESGPTREWVDAQLGETGPELPPRVANAADALDLLGTATTRFHPTRPNRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZU2</accession>
    <name>A0A231GZU2_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate-import protein PhnD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phnD</name>
        <name evidence="4" type="ORF">B7C42_05671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate/phosphite/phosphonate binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42072">
        <property type="protein sequence ID" value="OXR42072"/>
        <property type="gene ID" value="B7C42_05671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012263140" evidence="3">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="294" mass="31015" checksum="8460B62311520864" modified="2017-10-25" version="1">MNRFRALLGVLLALCLGILLTSCGSQSSSTNTIKLGAIATGSAPEEQARYQKIADQLAQKTGMKVDLVTSTDYYAIAEGLRGGKLDVAFLNSLGYVLTAPKAKIQPLAVGVDNTGQPGYYSYLITKKRDEIKGPADVKGHTLAIANKLSTSGYLFPLRAMQAAGVNSQKDTTLSAGGNHAANILAVASGQVDAAFVDSVEFEAAVKKGRVNPDEVSVVWKSDRISGSPVVARSDLPADRLEKIKQAVLGLTGTAETPLGVEKTMKMGEVEDSDYDPIRALAKQAGLSVDDLEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231GZU6</accession>
    <name>A0A231GZU6_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor FabR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabR_3</name>
        <name evidence="6" type="ORF">B7C42_05727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000015">
        <property type="protein sequence ID" value="OXR42128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42128">
        <property type="protein sequence ID" value="OXR42128"/>
        <property type="gene ID" value="B7C42_05727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXR42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="190" mass="19638" checksum="3E7C8394A09C6269" modified="2017-10-25" version="1">MALSTPSYHHGDLPNALVCAAVELLEEGGASELSLRAAARRAGVSPAAPYRHFADREALLSAVAAVGYGDLAEQLAAAHPEPATPEGLAAVANAYVRFALTRPGMFRVMFAEPCGSADVERVAAEAIEHFVENVVRRAFPRADPNAAATAVWALVHGLAFLHLDGKLDASSPEVVAATVNSTVFAALGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0L5</accession>
    <name>A0A231H0L5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039780710.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42420">
        <property type="protein sequence ID" value="OXR42420"/>
        <property type="gene ID" value="B7C42_05621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="292" mass="30865" checksum="8DC7D51EBE172D21" modified="2017-10-25" version="1">MNDRLKFAAFGGGLVVLFGAALGIGALVGDPAEPAPGHGTGLQATQEGYTLSEVAAPTEPRTPGTLRFRITGPDGAPVTRYTDLHERDLHLIAVRSDATEYRHVHPVRDDTGTWSIDWQWAQPGTYRIFADSRPATAPDELVLSRTVTVAGANADRPLPPVSRTTTVDGYQVRMDGDLSTGGGEVGFTVTRDGRPVTDLQPYLGAYGHLVALRGNDLSYLHVHPEGEAGSTPAGPRVAFHAQAPSAGAFRLYLDFAHGGAVHTAEFTAEAVAGQQSGQHDNEHNGQHGGGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0P5</accession>
    <name>A0A231H0P5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000014">
        <property type="protein sequence ID" value="OXR42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051043132.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42398">
        <property type="protein sequence ID" value="OXR42398"/>
        <property type="gene ID" value="B7C42_05599"/>
    </dbReference>
    <dbReference type="GeneID" id="66723298"/>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="104" mass="12463" checksum="AC7FCEA3A637DF05" modified="2017-10-25" version="1">MADDDTYPLMDEVFEMGDDEREDLDYDLGDDEQADEIREYQRYIDDPPDDLEIRYHENDDDGRLGIRSELDQEWTRRRHRQELRDEDERPAEVAAIEVVDEPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H0U1</accession>
    <name>A0A231H0U1_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xerC_4</name>
        <name evidence="4" type="ORF">B7C42_05239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42463">
        <property type="protein sequence ID" value="OXR42463"/>
        <property type="gene ID" value="B7C42_05239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="43229" checksum="A2494FC7B2CABE57" modified="2017-10-25" version="1">MSVSPDPVVVDIAVPEAVRTELRRGVRSVLVDTVALRMVRERFDTEQAGALGRYLEASQSPNTVRAYRSDWVGWSAWCAAEARCALPADALDVAVYLAAAADARKPSGEWAFGPATLERKSAAIAAVHAANGLPSPTRSDVVRLTLRGIRRTRRSVPNRKRPVLLHTLAQLLDGLPAPGWPTEPARRRDRLMLLVGFAGALRRSELAGLRVGDVAVTLDHRTGEPVLLVRLPATKTDPTGAGAQSVALPRGARPSTCPVCAFAEWIDLRDIHAVGGTDDLRAWTERTSAAGDIHRCHGFTGATRVDAQAPLFPPVSRHGGIGAQPISGRAVAELVKRYAARAGLDPALFSGHSLRAGFATQAALGGASDREIMRQGRWSNPRTVHGYIRTANPLEDNAVTKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H106</accession>
    <name>A0A231H106_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777372.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42533">
        <property type="protein sequence ID" value="OXR42533"/>
        <property type="gene ID" value="B7C42_05309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="149" mass="16911" checksum="5C5F536D3A22EE43" modified="2017-10-25" version="1">MTYESELDPAAVEIGGFFPHPPALLWRALTEPDLVERWLMRSIGLEPVVGTHFIFAVPTEPSAEIACEVVAARTGEQLTYTWIDLRAKFPARWVVDWMLEAQGRGTRVLLTQTGFDIGDRRQKMARNAMERGWRGTLNRLREVLDEVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H172</accession>
    <name>A0A231H172_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_05380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000013">
        <property type="protein sequence ID" value="OXR42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42603">
        <property type="protein sequence ID" value="OXR42603"/>
        <property type="gene ID" value="B7C42_05380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="303" mass="32562" checksum="A229CE24C5EDDF82" modified="2017-10-25" version="1">MKILIVGGTGMIGVHAALHLREHGDDVTVAGRGPIPADSPVAEFPLLPGDYTVPTFTPAQLEHFDGIVFAAGQDVRHKTPEDDTRRFWETTQSVGVPRFAALAKQAGVPRFVQVGSYYHQLRPDLAEHNPYIAARKAADEGVRALADDAFAACTLNPPSIIGAVPGPSARRYRRMVSWAAGNEPDIPDFAPPGGTNYMSAASLAQAIRGALVRGEPGTAYLVGDQNLSYREFFQMLVDAAGGGRTIAERDEQHRLQPDASIIQGRGNTLSYEPDAGQVRLLGYTRDDCVRALQALVDEVVAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1Q4</accession>
    <name>A0A231H1Q4_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acr1_6</name>
        <name evidence="1" type="ORF">B7C42_05117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42779">
        <property type="protein sequence ID" value="OXR42779"/>
        <property type="gene ID" value="B7C42_05117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="274" mass="28548" checksum="0589C90533738583" modified="2017-10-25" version="1">MAAEPNDIIDPHRYGPWAVIAGGSEGVGAEFADRLAAAGINIVLLARREGPLAETAERVAARGVQVRTLAVDLTAPDAAARVATATADVEVGLLVYNAGANTHSAEFLDGDLEAFAAMNALNVTAPLALVHHFGRGMRARGRGGIVLVGSLTGYCGSARHTVYGGSKAYLRIFAESLWLELREHNVDVLHLVLGVTRTPAMARAGLNFDIPGMLVAEPADVAREGLEQLANGPVFVAGGNAETAARSSGPDRAAIVLGGHRRMQKLIGAEPDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1T0</accession>
    <name>A0A231H1T0_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B7C42_05130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42792">
        <property type="protein sequence ID" value="OXR42792"/>
        <property type="gene ID" value="B7C42_05130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXR42792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="502" mass="53375" checksum="FD38036FEAF15185" modified="2017-10-25" version="1">MILTRFVRAQLVIFSILAVIGMVSMAVQYMRLPTLAGIGTMKVTLELPTSGGLYRFGNVTYRGVQIGKVTSVDLTDDAVKATLSIDGGHKIPADLRAQVRSVSAVGEQYVDLQPRTDAPPYLHDGSVIDVRDSTVPQPVGPMLDELDSLVGSIPKDRLHTMLDEVFTGVNGARYDLQSLLNSAATVAADANRTGDTTRELLAKAEPLMDSQDRSADAIRIWARSLAGVSGQIATDDEQVRTLLNTGPGAAREATTLLDSVKLTLPVLLSNLTSVAQLGVTYHAGLEQVLVLLPPEVSIVQAVQPTKNAQGLGPGDFRISGVSDPPACTVGFLPPSAWRPPSDTTTIDTPDGLYCKLPQDSPVAVRGARNFPCAGKPGKRAPTAEICNSDQEYEPVAPDQPVVGPYPRDPNLESQGIPPDSRWNPPAPAPAPAAPLPQLPQIELPRIPGLNAPAAARTGTEPSLGFAHYDPHTGNYLAPDGKMYRRDDLAGARPASWKDMVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H1W5</accession>
    <name>A0A231H1W5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase DeaD</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">deaD_1</name>
        <name evidence="11" type="ORF">B7C42_05155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="NGAF01000012">
        <property type="protein sequence ID" value="OXR42817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42817">
        <property type="protein sequence ID" value="OXR42817"/>
        <property type="gene ID" value="B7C42_05155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="90"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="300"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXR42817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="578" mass="62146" checksum="8E095A9DC63CF116" modified="2017-10-25" version="1">MEPAGNVVARKSGPNPPSCALDATNTRKARILSKITVEQEPGLADTLLTAELDSTHTTPTFAELGVRPEIVRALGEIGIEHTFAIQELTLPLALAGDDLIGQARTGMGKTFGFGVPLLHRISTADSGTTALDGTPRALVIVPTRELCVQVTQDLENAGKYLSNQKGRLRVTSIYGGRPYDAQIAALREGVDVVVGTPGRLLDLAEQQHLILGKVGVLVLDEADEMLDLGFLPDIERILSMVPEQRQTMLFSATMPGPIITLARTFLHKPTHIRAEEPSDSAVHDRTAQFVYRAHALDKSELIARILQAESRGATMIFTRTKRTAQKVADDLADRGFAVGAVHGDLGQIAREKALEKFRKGKIDVLVATDVAARGIDIDDVTHVVNYQCPEDEKTYVHRIGRTGRAGRTGVAVTLVDWDELHRWESINSALGLGIPEPVETYSRSEHLRSDLGIPENATGTVRRAPAREPDAVVEEREARQPRKRNRRRTRGGKAVDAAEGTTAESVDSATDTTESAAAQSVSDDQPASDAAEGDKPARRRRRRRRKPAAEAGDTTGGDDSAAESGSAATGGDHTAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H276</accession>
    <name>A0A231H276_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein LppK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lppK</name>
        <name evidence="2" type="ORF">B7C42_04828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42942">
        <property type="protein sequence ID" value="OXR42942"/>
        <property type="gene ID" value="B7C42_04828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR42942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="195" mass="19668" checksum="908907354E14AC43" modified="2017-10-25" version="1">MLLPTRHSVTPFGGSTRTGSNATRTAGVSGSRRLRLATATAFAALAVTAMTACGSDNSQDSTPTKATTATSASAAATSAAAAPAPTAEELQATLNGFVDPAKPTTEKEKLVVGGDKRAANIDTMTKGLANYGTITFTVADIKTEGDQATGQVTITSPHGPAGPMPMTWQHSAAGWQLSDASACQILAMGMAPCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2A5</accession>
    <name>A0A231H2A5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_04865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR42979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR42979">
        <property type="protein sequence ID" value="OXR42979"/>
        <property type="gene ID" value="B7C42_04865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR42979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="111" mass="11971" checksum="AF0E77A5E0C06FE7" modified="2017-10-25" version="1">MTISPVQNGWVPSACTLPTVEQPIRVAEFDRFFADAVRAVRRPHPHRLELILASGAESRARDLATRETGCCSFFVFDFDATEQAPVLSIGVPPAYTAVLDAIAARATGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2G5</accession>
    <name>A0A231H2G5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="3" type="ORF">B7C42_04921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43035">
        <property type="protein sequence ID" value="OXR43035"/>
        <property type="gene ID" value="B7C42_04921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="230" mass="23732" checksum="1B2DEDD19AEAC2DB" modified="2017-10-25" version="1">MLLRTEIRIVARAGALPWSAATGALAVRCTGPDTVHLIGAAATPLGGDELDIRIAVEPGARLVVRSVAATIVLPGRITRTSTASWSLDVGAGGELDFDPEPTVVAGGADHRVVTTVRLAADARIRIRERVQIGRTGEDHGRWCGDFVADLAALPLLRHRLELGAGTAADDLLSAPRALCSELRYPDDSPATTTGVAAALLPLAAGGSLSTWTGARLSEAPGGRRLCVDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2P5</accession>
    <name>A0A231H2P5_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purF_2</name>
        <name evidence="1" type="ORF">B7C42_05007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777904.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43121">
        <property type="protein sequence ID" value="OXR43121"/>
        <property type="gene ID" value="B7C42_05007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="252" mass="27878" checksum="894E44FE1125E361" modified="2017-10-25" version="1">MCILTFYKPGQDPDLDALHGGALANPHGHGYAIHTDDTILVGHGMNAEQVITEFAEQRAKHPNGPALFHSRYATHGDRDTSNCHPFIVGGNQRTVLAHNGILPDNVHPAPGDSRSDTRIAAEDFLPTNPFGSLDSWAGRSRFEHWLASNKVVILTTDPAYKHPAYIFNEHHGHWIGGIWYSNDSYLIREWASADTDYIGFCEYCGAFEDEPFGPHCGSCGYCADCMHPFPRCACPQFDGADRYADLLGLQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2R8</accession>
    <name>A0A231H2R8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B7C42_05003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000011">
        <property type="protein sequence ID" value="OXR43117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039777907.1">
        <property type="nucleotide sequence ID" value="NZ_JAAXOR010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43117">
        <property type="protein sequence ID" value="OXR43117"/>
        <property type="gene ID" value="B7C42_05003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="191" mass="21514" checksum="63FCB271093068DF" modified="2017-10-25" version="1">MTESQRDEVANVASAVSRCLSDLEPVFEQIDWAEDEIARAQQRHTRHRNTVYHSFALLMPTHERMRQEFVYRSHCRELLDRVAAGLSPVYGTAAEVALTVMEASQKAPLNTAAFGLYVRMWIQAGFPHVESVTGSHEHYEAIAKSRIDDLEAETRTRLSVADRVLRAIDCPGRHHGQPADDCQYARPSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2V3</accession>
    <name>A0A231H2V3_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="2">1.2.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdhB_2</name>
        <name evidence="2" type="ORF">B7C42_04601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43179">
        <property type="protein sequence ID" value="OXR43179"/>
        <property type="gene ID" value="B7C42_04601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="334" mass="35243" checksum="4AD33909A448A784" modified="2017-10-25" version="1">MTIAEQPVQTRTLGFVQAINDALDIALETDERVFALGEDIQEPGGGGFGVFKGLGKKYGTQRIRHTPISEQAIMGAAIGAAISGLRPVPEIMLMNFTHVCMDQLVNHAAKLRYMSGGRTPVPITVRTATGAGGGFGAQHSDMLEAQLVHAAGLKVVVPSNPADAKGLLLSSIFDDDPVVFVEMFGLYFASRGEVPVGDHRVPLGKAAIARPGSDVTILTYGRQVVDCLAVAEQLATEGIDVEVVDLRTLQPLDIETVLASVAKTKRAVVVHEAVRRNGFGAELAATIHSELFGELAGPVARVTAPNTPVPYAKSLEQAYIPGPPQIEAAVRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2X9</accession>
    <name>A0A231H2X9_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA:oxalate CoA-transferase</fullName>
            <ecNumber evidence="1">2.8.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uctC_3</name>
        <name evidence="1" type="ORF">B7C42_04633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.19" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064909017.1">
        <property type="nucleotide sequence ID" value="NZ_NGAF01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43211">
        <property type="protein sequence ID" value="OXR43211"/>
        <property type="gene ID" value="B7C42_04633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXR43211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="394" mass="41982" checksum="0D649B568ACA4A89" modified="2017-10-25" version="1">MGELPLQGVVVVSLEQAVAAPYATRQLADLGARVIKIERPGAGDFARGYDTTVLGQSSYFAWLNRSKESLTLDLKSENGREVLHRLLAGADVFVQNLGPGAVARMGLGVDRLAQRYPTVIPCGISGYGGDGPWQSRKAYDLLVQAEAGLLSVTGTDADVAKAGISVADIAAGSFAFSGILTALYTRATTGRVRAVSVSLFEALVEWMGSPLYYARYGGTAPVRTGARHATIAPYGPFTAGDGGTVLLAVQNDREWQRLCAEVLERPELITDPRFATNPGRVAHRDELESIIAAVTNSLTTQALIARLESAAIATARINDMTQVWEHPVLAVRDRWRQVDTPGGDIRALLPPAALDGVEPRMDPVPAVGAHTEAVLHELGFSAAEIQRFRSAGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Y7</accession>
    <name>A0A231H2Y7_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B7C42_04642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43220">
        <property type="protein sequence ID" value="OXR43220"/>
        <property type="gene ID" value="B7C42_04642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="104"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXR43220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="404" mass="45312" checksum="035E329E0D72C444" modified="2017-10-25" version="1">MPLQDSMQMISVDDHLIEPPSVWVDRLPKKFVEDGPRIVEMDMSQNAGDEELSKVLLDAARGGGRGAERLAEVWVYEGRVYPNIGLNAVAGKKPQEYGMDPTRYSDMLPGCYDPVARIADMDVDGVQAALCFPSFPRFSGTVFLEGKDKELALLSVRAWNDFHLDEWAAAAPDRFIPLIILPLWDPAAAAAEIYRCAAKGAKAITFPECTVPLGLPSFYTDHWDPVFAAAQETGLPLCMHFGSSGRPPITSPEAPMAVMISLFGTNSMYATADLLFSPVFYKFPNLKVALSEGGVGWVPYLLERIDQVWEKHRWYQNVNKEVRPSDLFREHIWGCFIDDSEGIVRREAIGVDNILWECDYPHSDSNWPNSREFTGKLLQNVPDDEAHKIVELNARKLFNFPRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H2Y8</accession>
    <name>A0A231H2Y8_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3-dihydroxyphenylpropionate/2, 3-dihydroxicinnamic acid 1,2-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhpB_2</name>
        <name evidence="2" type="ORF">B7C42_04626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.16" evidence="2"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43204">
        <property type="protein sequence ID" value="OXR43204"/>
        <property type="gene ID" value="B7C42_04626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047070">
        <property type="term" value="F:3-carboxyethylcatechol 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="287" mass="30583" checksum="3D628F4EBA27DEA6" modified="2017-10-25" version="1">MSGPDRLIVCASHSPGMMRDVEHVYGKEFRDGLARVRALVEEFAPDVVVLFGGDHRRAFRKVVPSFAVALSAAIMAEAGRSAGALRVPPEPARGLADHLLDAGFDITVCRDIELDHAFAQPLHDLTEGLAAYPVIPVPINCATAPLPTPGRVLEFGAAVGNFLDGLDERVLVIGTGGLSHSPPSLEVDTHDMSDEERARIIAAGYAAAEKKIRPEWDRAFLDALTTWDATRLAELAAVATEQAGVGANEVRTWLAAGAAGGGKPFECVSYEPVEKWITGMGLAISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H363</accession>
    <name>A0A231H363_9NOCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B7C42_04680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43258">
        <property type="protein sequence ID" value="OXR43258"/>
        <property type="gene ID" value="B7C42_04680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="73"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXR43258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215506"/>
        </source>
    </evidence>
    <sequence length="439" mass="44320" checksum="9DBBB146DD2C79C7" modified="2017-10-25" version="1">MPHLFIRPGCTGSPGSRLEIEVHFPRTPGRIAAPLMIAAALAVATACSSSSTSDSTPSAEPIAGSPNKAAGTPVTIGFISEGKSPAIDNTDEIKGARAAVAYANDYLGGLGGHPITLKVCESLGQPATATDCANQMVAADVAAVVEGVEGQIDATIAPLAAAKIPLVTHTASTQAALQTPGVFMLLNGLSYFGTPAAQAKADGVKKADLVVIGVPAAEGPARQIGALLYGNAGVGLNVTAVPPGTADMTPQIAAADGEHPDLYTVVGNDTFCTSALKAIKTVDPSVKTTIIDRCITPGGASAIPGGYQDINVVTTTDLSKDRPDGKLFASVLSKYGDGAKFGSTAAFGYSPMLGMVDALNAAKISEPTPATVTSTLQSAPATEYPLSGGVMFQCNGKQIALSPNICSTDGIMATADKAGTLSNYRRVAADAKLYSMPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A231H372</accession>
    <name>A0A231H372_9NOCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-methylmalyl-CoA dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.148</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mch_2</name>
        <name evidence="1" type="ORF">B7C42_04674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nocardia cerradoensis</name>
        <dbReference type="NCBI Taxonomy" id="85688"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Nocardiaceae</taxon>
            <taxon>Nocardia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-07" db="EMBL/GenBank/DDBJ databases">
            <title>First draft Genome Sequence of Nocardia cerradoensis isolated from human infection.</title>
            <authorList>
                <person name="Carrasco G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNM20130759</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.148" evidence="1"/>
    <dbReference type="EMBL" id="NGAF01000010">
        <property type="protein sequence ID" value="OXR43252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OXR43252">
        <property type="protein sequence ID" value="OXR43252"/>
        <property type="gene ID" value="B7C42_04674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215506">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom
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